PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17956310-2	2007	Remarkably, in addition to its role in Ca(2+)(o) (extracellular Ca(2+)) sensing, the CaR (Ca(2+)-sensing receptor) also responds to L-amino acids.	Amino Acids	132-145	calcium sensing receptor	Homo sapiens	85-88
17956310-2	2007	Remarkably, in addition to its role in Ca(2+)(o) (extracellular Ca(2+)) sensing, the CaR (Ca(2+)-sensing receptor) also responds to L-amino acids.	Amino Acids	132-145	calcium sensing receptor	Homo sapiens	90-113
17912467-4	2007	The aim of our current study was to examine the alteration of each isoform of adiponectin and its receptors (AdipoR1, AdipoR2, and T-cadherin) during the choline-deficient L-amino acid-defined (CDAA) diet-induced rat liver fibrosis development.	Amino Acids	172-184	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	78-89
17912467-4	2007	The aim of our current study was to examine the alteration of each isoform of adiponectin and its receptors (AdipoR1, AdipoR2, and T-cadherin) during the choline-deficient L-amino acid-defined (CDAA) diet-induced rat liver fibrosis development.	Amino Acids	172-184	adiponectin receptor 1	Rattus norvegicus	109-116
17912467-4	2007	The aim of our current study was to examine the alteration of each isoform of adiponectin and its receptors (AdipoR1, AdipoR2, and T-cadherin) during the choline-deficient L-amino acid-defined (CDAA) diet-induced rat liver fibrosis development.	Amino Acids	172-184	cadherin 13	Rattus norvegicus	131-141
17942718-1	2007	In taste bud cells, two different T1R heteromeric taste receptors mediate signal transduction of sugars (the canonical "sweet" taste receptor, T1R2 + T1R3) and L-amino acids (the T1R1 + T1R3 receptor).	Amino Acids	160-173	taste receptor, type 1, member 3	Mus musculus	150-154
17942718-1	2007	In taste bud cells, two different T1R heteromeric taste receptors mediate signal transduction of sugars (the canonical "sweet" taste receptor, T1R2 + T1R3) and L-amino acids (the T1R1 + T1R3 receptor).	Amino Acids	160-173	taste receptor, type 1, member 1	Mus musculus	179-199
17387224-3	2007	The length of FLT3-ITDs varied from 2 to 42 amino acids (AAs) with a median of 17 AAs.	Amino Acids	57-60	fms related receptor tyrosine kinase 3	Homo sapiens	14-18
17629624-1	2007	T1R2/T1R3 heterodimers are selectively responsive to sweet substances whereas T1R1/T1R3 receptors are selective for umami substances, represented by monosodium glutamate (MSG), and for L-amino acids.	Amino Acids	185-198	taste 1 receptor member 3	Rattus norvegicus	78-87
17387224-3	2007	The length of FLT3-ITDs varied from 2 to 42 amino acids (AAs) with a median of 17 AAs.	Amino Acids	82-85	fms related receptor tyrosine kinase 3	Homo sapiens	14-18
17295234-1	2007	We investigated DNA methylation patterns of E-cadherin and Connexin26 (Cx26) genes in rat hepatocellular carcinomas (HCCs) induced by a choline-deficient L-Amino Acid-defined (CDAA) diet.	Amino Acids	154-166	gap junction protein, beta 2	Rattus norvegicus	59-69
17589864-3	2007	The results are strongly in favor of the view that replacement of the Aib residues at positions 1, 8, and 16 with TOAC (both are members of the helicogenic sub-class of C(alpha)-tetrasubstituted alpha-amino acids) does not significantly affect the overwhelmingly populated alpha-helical 3D structure of alamethicin.	Amino Acids	195-212	ANIB1	Homo sapiens	70-73
17212589-0	2007	Allosteric activation of the extracellular Ca2+-sensing receptor by L-amino acids enhances ERK1/2 phosphorylation.	Amino Acids	68-81	mitogen-activated protein kinase 3	Homo sapiens	91-97
17212589-3	2007	In addition to Ca2+o, the CaR is activated allosterically by several subclasses of L-amino acids, including the aromatics L-phenylalanine and L-tryptophan.	Amino Acids	83-96	calcium sensing receptor	Homo sapiens	26-29
17212589-7	2007	In the present study, we examined the effects of L-amino acids on Ca2+o-stimulated ERK1/2 phosphorylation as determined by Western blotting and a newly developed quantitative assay (SureFire).	Amino Acids	49-62	mitogen-activated protein kinase 3	Homo sapiens	83-89
17212589-8	2007	L-Amino acids induced a small, but significant, enhancement of Ca2+o-stimulated ERK1/2.	Amino Acids	0-13	mitogen-activated protein kinase 3	Homo sapiens	80-86
17371247-2	2007	This finding gave rise to the question of the mechanism by which nutrients, such as AAs (amino acids), enter the mTOR (mammalian target of rapamycin)/S6K1 signalling pathway.	Amino Acids	84-87	mechanistic target of rapamycin kinase	Homo sapiens	113-117
17371247-2	2007	This finding gave rise to the question of the mechanism by which nutrients, such as AAs (amino acids), enter the mTOR (mammalian target of rapamycin)/S6K1 signalling pathway.	Amino Acids	84-87	mechanistic target of rapamycin kinase	Homo sapiens	119-148
17371247-2	2007	This finding gave rise to the question of the mechanism by which nutrients, such as AAs (amino acids), enter the mTOR (mammalian target of rapamycin)/S6K1 signalling pathway.	Amino Acids	84-87	ribosomal protein S6 kinase B1	Homo sapiens	150-154
17371247-5	2007	In brief, ectopic expression of hVps34 drives S6K1 activation, but only in the presence of AAs, and this effect is blocked by small interfering RNAs directed against hVps34.	Amino Acids	91-94	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	32-38
17371247-6	2007	Moreover, stimulation of cells with AAs increases hVps34 activity, as indicated by the production of PI3P (phosphatidylinositol 3-phosphate).	Amino Acids	36-39	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	50-56
17294180-1	2007	There have been several attempts over the years to identify positions in the peptide-binding region (PBR) of human leukocyte antigens (HLA) that influence the specificity of bound amino acids (AAs) at each position in the peptide.	Amino Acids	193-196	translocator protein	Homo sapiens	77-99
17294180-1	2007	There have been several attempts over the years to identify positions in the peptide-binding region (PBR) of human leukocyte antigens (HLA) that influence the specificity of bound amino acids (AAs) at each position in the peptide.	Amino Acids	193-196	translocator protein	Homo sapiens	101-104
17509526-2	2007	In our ongoing effort of MUC2 vaccine development, we have solved the NMR structure of the all L-amino acid and various D-amino acid-substituted derivatives of the peptide TPTPTGTQTPT, previously identified as an epitope within the tandem repeat unit of the MUC2 glycoprotein.	Amino Acids	95-107	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	25-29
17295234-0	2007	CpG site hypermethylation of E-cadherin and Connexin26 genes in hepatocellular carcinomas induced by a choline-deficient L-Amino Acid-defined diet in rats.	Amino Acids	121-133	cadherin 1	Rattus norvegicus	29-39
17295234-0	2007	CpG site hypermethylation of E-cadherin and Connexin26 genes in hepatocellular carcinomas induced by a choline-deficient L-Amino Acid-defined diet in rats.	Amino Acids	121-133	gap junction protein, beta 2	Rattus norvegicus	44-54
17295234-1	2007	We investigated DNA methylation patterns of E-cadherin and Connexin26 (Cx26) genes in rat hepatocellular carcinomas (HCCs) induced by a choline-deficient L-Amino Acid-defined (CDAA) diet.	Amino Acids	154-166	gap junction protein, beta 2	Rattus norvegicus	71-75
17245368-2	2007	We have recently described both human and mouse GPRC6A as receptors for L-alpha-amino acids.	Amino Acids	72-91	G protein-coupled receptor, family C, group 6, member A	Mus musculus	48-54
17245368-8	2007	KEY RESULTS: Using our novel assay, we demonstrate that the basic L-alpha-amino acids ornithine, lysine, and arginine are the most potent agonists at wild-type mouse GPRC6A.	Amino Acids	66-85	G protein-coupled receptor, family C, group 6, member A	Mus musculus	166-172
16964560-0	2007	Enantiopure beta3-amino acids-2,2-d2 via homologation of proteinogenic alpha-amino acids.	Amino Acids	71-88	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	12-17
17089339-2	2007	The new CSP was quite effective in the resolution of various racemic alpha-amino acids, amines, and amino alcohols, and the chiral recognition efficiency of the new CSP was even greater than that of the corresponding singly tethered CSP especially in terms of the resolution factors (RS).	Amino Acids	69-86	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	8-11
17089339-2	2007	The new CSP was quite effective in the resolution of various racemic alpha-amino acids, amines, and amino alcohols, and the chiral recognition efficiency of the new CSP was even greater than that of the corresponding singly tethered CSP especially in terms of the resolution factors (RS).	Amino Acids	69-86	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	165-168
17089339-2	2007	The new CSP was quite effective in the resolution of various racemic alpha-amino acids, amines, and amino alcohols, and the chiral recognition efficiency of the new CSP was even greater than that of the corresponding singly tethered CSP especially in terms of the resolution factors (RS).	Amino Acids	69-86	DnaJ heat shock protein family (Hsp40) member C5	Homo sapiens	165-168
17311762-3	2007	In this study, we used a choline-deficient l-amino acid (CDAA)-defined rat hepatocarcinogenesis model to visualize increased in vivo expression of the c-MET antigen in neoplastic lesion formation with the use of a super paramagnetic iron oxide (SPIO)-anti-c-MET molecularly targeted magnetic resonance imaging (MRI) contrast agent.	Amino Acids	43-55	MET proto-oncogene, receptor tyrosine kinase	Rattus norvegicus	151-156
16829127-1	2006	The proton affinities (PA) of the 20 naturally occurring alpha-amino acids (AA) have been determined computationally by means of density functional theory (DFT) and high-level G2(MP2) calculations.	Amino Acids	57-74	tryptase pseudogene 1	Homo sapiens	179-182
17030896-3	2006	The extracellular calcium-sensing receptor (CaR) is a multimodal sensor for several key nutrients, notably Ca2+ ions and L-amino acids, and is expressed abundantly throughout the gastrointestinal tract.	Amino Acids	121-134	calcium sensing receptor	Homo sapiens	44-47
17165727-3	2006	Depending on the lengths of the spacers, these metal complexes with pendent alpha-amino acids are recognized and transported by the l-type amino acid transporter LAT1.	Amino Acids	76-93	solute carrier family 7 member 5	Homo sapiens	162-166
17165790-2	2006	The present study shows that the enhancement of carbon acidity of alpha-amino acids by the cofactor pyridoxal 5"-phosphate (PLP) with an unusual, unprotonated pyridine is mainly due to solvation effects, in contrast to the intrinsic electron-withdrawing stabilization by the pyridinium ion to form a quinonoid intermediate.	Amino Acids	66-83	pyridoxal phosphatase	Homo sapiens	124-127
16919500-4	2006	The effect of AT-II type 1 receptor blocker (ARB) was assessed on several indices of choline-deficient l-amino acid-defined (CDAA)-induced liver fibrogenesis.	Amino Acids	103-115	angiotensinogen	Rattus norvegicus	14-19
16530883-3	2006	We found that [Trp3, Arg5]-ghrelin(1-5) (GSWFR), a novel pentapeptide composed of all L-amino acids, had affinity for the GHS receptor (IC50 = 10 microM).	Amino Acids	86-99	ghrelin	Mus musculus	27-34
16836380-3	2006	Chiral amines, esters of alpha-amino acids, and beta-amino alcohol afforded optically pure N-t-Boc derivatives.	Amino Acids	25-42	BOC cell adhesion associated, oncogene regulated	Homo sapiens	95-98
16730978-4	2006	Excellent CA XIII activating properties were shown by D-amino acids (His, Phe, DOPA, and Trp), serotonin, and 4-(2-aminoethyl)-morpholine, whereas the corresponding L-amino acids, dopamine, histamine, and 1-(2-aminoethyl)-piperazine, were weaker activators.	Amino Acids	165-178	carbonic anhydrase 13	Homo sapiens	10-17
16827801-4	2006	To elucidate the status of NEP in HCC, methylation in the promoter region of the gene that encodes NEP in male Fischer 344 rats with HCC, induced by a choline-deficient, l-amino acid-defined diet, was investigated by methylation-specific polymerase chain reaction, combined bisulfite restriction analysis, and bisulfite genomic sequencing.	Amino Acids	170-182	membrane metallo-endopeptidase	Rattus norvegicus	27-30
16827801-4	2006	To elucidate the status of NEP in HCC, methylation in the promoter region of the gene that encodes NEP in male Fischer 344 rats with HCC, induced by a choline-deficient, l-amino acid-defined diet, was investigated by methylation-specific polymerase chain reaction, combined bisulfite restriction analysis, and bisulfite genomic sequencing.	Amino Acids	170-182	membrane metallo-endopeptidase	Rattus norvegicus	99-102
16732620-3	2006	In this work, a fast and sensitive method based on MEKC-LIF has been developed to analyze and quantitate L-amino acid (L-aa) and D-aa in vinegars.	Amino Acids	105-117	LIF interleukin 6 family cytokine	Homo sapiens	56-59
16530883-3	2006	We found that [Trp3, Arg5]-ghrelin(1-5) (GSWFR), a novel pentapeptide composed of all L-amino acids, had affinity for the GHS receptor (IC50 = 10 microM).	Amino Acids	86-99	growth hormone secretagogue receptor	Mus musculus	122-134
16466923-0	2006	Design, synthesis, and evaluation of new type of L-amino acids containing pyridine moiety as nitric oxide synthase inhibitor.	Amino Acids	49-62	nitric oxide synthase 2	Homo sapiens	93-114
16787057-2	2006	The present studies show that enhancement of carbon acidity of alpha-amino acids by cofactor pyridoxal 5"-phosphate, PLP, with an unusual, unprotonated pyridine is due to solvation effects, in contrast to the intrinsic electron-withdrawing stabilization by the pyridinium ion to form a quinonoid intermediate.	Amino Acids	63-80	proteolipid protein 1	Homo sapiens	117-120
16599644-0	2006	Efficient synthesis of beta2-amino acid by homologation of alpha-amino acids involving the Reformatsky reaction and Mannich-type imminium electrophile.	Amino Acids	59-76	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	23-28
16599644-2	2006	We report here our findings on a new and highly efficient general strategy for the synthesis of beta2-amino acids by homologation of alpha-amino acids, involving the Reformatsky reaction and Mannich-type imminium electrophile.	Amino Acids	133-150	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	96-101
16274742-0	2006	Pb(II)-binding capability of aminohydroxamic acids: primary hydroxamic acid derivatives of alpha-amino acids as possible sequestering agents for Pb(II).	Amino Acids	91-108	submaxillary gland androgen regulated protein 3B	Homo sapiens	0-6
16274742-0	2006	Pb(II)-binding capability of aminohydroxamic acids: primary hydroxamic acid derivatives of alpha-amino acids as possible sequestering agents for Pb(II).	Amino Acids	91-108	submaxillary gland androgen regulated protein 3B	Homo sapiens	145-151
16513561-8	2006	The novel L,(L/D)-aminopeptidase also hydrolyzed alanine-4-nitroanilide (K(M)=0.6 mM) and several peptides comprising L-amino acids.	Amino Acids	118-131	carboxypeptidase Q	Homo sapiens	18-32
16267254-4	2005	One theoretical source of reactive aldehydes is oxidation of common alpha-amino acids by myeloperoxidase (MPO) released by leukocytes.	Amino Acids	68-85	myeloperoxidase	Mus musculus	89-104
16277424-1	2005	The activity of tyrosinase (EC 1.14.18.1) on selected (R)-betaxanthins is characterized in depth, demonstrating that the activity of the enzyme is not restricted to betaxanthins derived from (S)-amino acids.	Amino Acids	191-206	tyrosinase	Homo sapiens	16-26
16267254-4	2005	One theoretical source of reactive aldehydes is oxidation of common alpha-amino acids by myeloperoxidase (MPO) released by leukocytes.	Amino Acids	68-85	myeloperoxidase	Mus musculus	106-109
16021648-0	2005	Induced axial chirality in the biphenyl core of the proatropoisomeric, C alpha-tetrasubstituted alpha-amino acid residue Bip in peptides.	Amino Acids	96-112	heat shock protein family A (Hsp70) member 5	Homo sapiens	121-124
15961860-4	2005	To determine whether the endogenously expressed parietal cell CaSR is allosterically activated by L-amino acids, we examined the effect of the amino acids L-phenylalanine (L-Phe), L-tryptophan, and L-leucine on acid secretion.	Amino Acids	98-111	calcium sensing receptor	Homo sapiens	62-66
15961860-3	2005	When overexpressed in HEK-293 cells, the CaSR can be allosterically activated by L-amino acids in the presence of physiological concentrations of extracellular Ca(2+) (Ca(o)(2+); 1.5-2.5 mM).	Amino Acids	81-94	calcium sensing receptor	Homo sapiens	41-45
15887118-3	2005	METHODS: We analyzed HHM expression in the choline-deficient L-amino acid defined (CDAA) diet model of rat hepatocarcinogenesis and in human adenomatous hyperplasia (AH) and hepatocellular carcinoma (HCC) biopsy samples.	Amino Acids	61-73	cyclin D1 binding protein 1	Homo sapiens	21-24
16085455-0	2005	The peroxisome proliferator-activated receptor-gamma agonist, pioglitazone, inhibits fat accumulation and fibrosis in the livers of rats fed a choline-deficient, l-amino acid-defined diet.	Amino Acids	162-174	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	4-52
15574816-1	2004	Recent research has implicated T1R1/T1R3 as the primary taste receptor in mammals for detecting L-amino acids, including L-monosodium glutamate (MSG) and L-alanine.	Amino Acids	96-109	taste 1 receptor member 3	Rattus norvegicus	31-40
15576628-5	2005	Homology modeling of the hGPRC6A ATD based on the crystal structure of the metabotropic glutamate receptor subtype 1 predicted interaction with alpha-amino acids and was employed to rationally select potential ligands.	Amino Acids	144-161	G protein-coupled receptor class C group 6 member A	Homo sapiens	25-32
15644866-4	2005	At extracellular pH 5.5 (in Na(+)-free conditions) proline uptake was saturable (Km 172+/-41 muM), demonstrating that rPAT2 is, relative to PAT1, a high-affinity transporter.PAT2 preferred substrates are L-alpha-amino acids with small aliphatic side chains (e.g. the methyl group in alanine) and 4- or 5-membered heterocyclic amino and imino acids such as 2-azetidine-carboxylate, proline and cycloserine, where both D- and L-enantiomers are transported.	Amino Acids	204-223	solute carrier family 36 member 2	Rattus norvegicus	118-123
15644866-4	2005	At extracellular pH 5.5 (in Na(+)-free conditions) proline uptake was saturable (Km 172+/-41 muM), demonstrating that rPAT2 is, relative to PAT1, a high-affinity transporter.PAT2 preferred substrates are L-alpha-amino acids with small aliphatic side chains (e.g. the methyl group in alanine) and 4- or 5-membered heterocyclic amino and imino acids such as 2-azetidine-carboxylate, proline and cycloserine, where both D- and L-enantiomers are transported.	Amino Acids	204-223	solute carrier family 36 member 2	Rattus norvegicus	119-123
15469284-0	2004	Induced axial chirality in the biphenyl core of the Calpha-tetrasubstituted alpha-amino acid residue Bip and subsequent propagation of chirality in (Bip)n/Val oligopeptides.	Amino Acids	76-92	heat shock protein family A (Hsp70) member 5	Homo sapiens	101-104
15525493-3	2004	The CaR is activated by Ca2+ and Mg2+ present in the extracellular fluids, various di- and trivalent cations, L-aminoacids and charged molecules including several antibiotics.	Amino Acids	110-122	calcium sensing receptor	Homo sapiens	4-7
15469284-0	2004	Induced axial chirality in the biphenyl core of the Calpha-tetrasubstituted alpha-amino acid residue Bip and subsequent propagation of chirality in (Bip)n/Val oligopeptides.	Amino Acids	76-92	heat shock protein family A (Hsp70) member 5	Homo sapiens	149-152
15234970-9	2004	In conclusion, l-amino acids acutely and reversibly activate endogenous CaRs and suppress PTH secretion at physiological concentrations.	Amino Acids	15-28	parathyroid hormone	Homo sapiens	90-93
15234970-10	2004	The results indicate that l-amino acids are physiological regulators of PTH secretion and thus whole body calcium metabolism.	Amino Acids	26-39	parathyroid hormone	Homo sapiens	72-75
15265498-2	2004	A variety of alpha-amino acid derivatives were prepared as glycine transport inhibitors and their ability to block the uptake of [(14)C]-glycine in COS7 cells transfected with human glycine transporter-2 (hGlyT-2) was evaluated.	Amino Acids	13-29	glycoprotein alpha-galactosyltransferase 1 (inactive)	Homo sapiens	205-212
15265498-4	2004	Compounds prepared from l-amino acids were more potent GlyT-2 inhibitors than analogs derived from the corresponding d-amino acids.	Amino Acids	24-37	glycoprotein alpha-galactosyltransferase 1 (inactive)	Homo sapiens	55-61
12765947-5	2003	Insulin reduced muscle release of AAs mainly by inhibition of protein breakdown.	Amino Acids	34-37	insulin	Homo sapiens	0-7
15313920-0	2004	Suppression of human prostate tumor growth in mice by a cytolytic D-, L-amino Acid Peptide: membrane lysis, increased necrosis, and inhibition of prostate-specific antigen secretion.	Amino Acids	70-82	kallikrein related peptidase 3	Homo sapiens	146-171
15026304-2	2004	Renal d-amino-acid oxidase (DAO) is associated with conversion of d-amino acids to the corresponding alpha-keto acids, but its contribution in vivo is poorly understood because the alpha-keto acids and/or l-amino acids formed are indistinguishable from endogenous compounds.	Amino Acids	205-218	D-amino acid oxidase	Mus musculus	28-31
14568261-0	2003	Osteoactivin expressed during cirrhosis development in rats fed a choline-deficient, L-amino acid-defined diet, accelerates motility of hepatoma cells.	Amino Acids	85-97	glycoprotein nmb	Rattus norvegicus	0-12
12953189-1	2003	A library of novel dipeptide-analogue ligands based on the combination of tert-butoxycarbonyl(N-Boc)-protected alpha-amino acids and chiral vicinal amino alcohols were prepared.	Amino Acids	111-128	BOC cell adhesion associated, oncogene regulated	Homo sapiens	96-99
15234970-0	2004	L-amino acids regulate parathyroid hormone secretion.	Amino Acids	0-13	parathyroid hormone	Homo sapiens	23-42
15234970-3	2004	Herein we show that in physiological concentrations, l-amino acids acutely and reversibly activated the extracellular Ca(2+)-sensing receptor in normal human parathyroid cells and inhibited parathyroid hormone secretion.	Amino Acids	53-66	calcium sensing receptor	Homo sapiens	118-141
15234970-3	2004	Herein we show that in physiological concentrations, l-amino acids acutely and reversibly activated the extracellular Ca(2+)-sensing receptor in normal human parathyroid cells and inhibited parathyroid hormone secretion.	Amino Acids	53-66	parathyroid hormone	Homo sapiens	190-209
15234970-4	2004	Individual l-amino acids, especially of the aromatic and aliphatic classes, as well as plasma-like amino acid mixtures, stereoselectively mobilized Ca(2+) ions in normal human parathyroid cells in the presence but not the absence of the CaR agonists, extracellular Ca(2+) (Ca(2+)(o)), or spermine.	Amino Acids	11-24	calcium sensing receptor	Homo sapiens	237-240
14961607-0	2004	Synthesis of all nineteen appropriately protected chiral alpha-hydroxy acid equivalents of the alpha-amino acids for Boc solid-phase depsi-peptide synthesis.	Amino Acids	95-112	BOC cell adhesion associated, oncogene regulated	Homo sapiens	117-120
14986650-2	2004	A new study using knockout mouse models shows that the detection of various sugars, artificial sweeteners and L-amino acids is exclusively mediated by taste cells that express one or pair-wise combinations of three G protein coupled receptors, T1R1, T1R2 and T1R3	Amino Acids	110-123	taste receptor, type 1, member 1	Mus musculus	244-248
14986650-2	2004	A new study using knockout mouse models shows that the detection of various sugars, artificial sweeteners and L-amino acids is exclusively mediated by taste cells that express one or pair-wise combinations of three G protein coupled receptors, T1R1, T1R2 and T1R3	Amino Acids	110-123	taste receptor, type 1, member 2	Mus musculus	250-254
14671042-7	2004	The HOCl-induced decrease in serum PON1 activity was completely removed by reaction of HOCl with a 2.7-fold excess of alpha-amino acids but not taurine.	Amino Acids	118-135	paraoxonase 1	Homo sapiens	35-39
14526263-3	2003	Because the plasma level of several amino acids (AAs) is increased in DM, we evaluated whether AAs could represent an effective osmotic stimulus for VP secretion.	Amino Acids	95-98	arginine vasopressin	Homo sapiens	149-151
12824035-4	2003	A variety of L-amino acid inputs were used to probe the S2 pocket of the tissue factor (TF) VIIa enzyme to influence both potency and selectivity.	Amino Acids	13-25	coagulation factor III, tissue factor	Homo sapiens	73-86
12824035-4	2003	A variety of L-amino acid inputs were used to probe the S2 pocket of the tissue factor (TF) VIIa enzyme to influence both potency and selectivity.	Amino Acids	13-25	coagulation factor III, tissue factor	Homo sapiens	88-90
12893527-3	2003	By using the Xenopus laevis oocytes as an expression system and by combining the two-electron voltage clamp technique with radiotracer flux studies, it was demonstrated that the aliphatic side chain of L-alpha-amino acids substrates can consist maximally of only one CH2-unit for high affinity interaction with PAT1.	Amino Acids	202-221	solute carrier family 36 member 1	Homo sapiens	311-315
12818190-1	2003	One of haemorrhagic toxins present in snake venoms is L-amino acid oxidase (LAO), which catalyzes the oxidative deamination of L-amino acids with the generation of hydrogen peroxide.	Amino Acids	127-140	interleukin 4 induced 1	Homo sapiens	76-79
12708866-5	2003	Finally, the potential synthetic utility of the present method for the practical asymmetric synthesis of structurally diverse natural and unnatural alpha-amino acids has been demonstrated by its successful application to the facile asymmetric syntheses of (S)-N-acetylindoline-2-carboxylate, a key intermediate in the synthesis of the ACE inhibitor, and l-Dopa (l-3,4-dihydroxyphenylalanine) ester and its analogue.	Amino Acids	148-165	angiotensin I converting enzyme	Homo sapiens	335-338
11907037-2	2002	LAO reacted with l-amino acids in an apparent order of Phe > Met, Tyr > Cys, Leu > His other 11 amino acids tested and produced H(2)O(2) in a dose- and time-dependent manner.	Amino Acids	17-30	interleukin 4 induced 1	Mus musculus	0-3
12693939-1	2003	Aminoacylase 1 is a zinc-binding metalloprotease catalyzing the hydrolysis of N(alpha)-acylated l-amino acids; it presents altered expression levels in different renal and small cell lung carcinomas.	Amino Acids	96-109	aminoacylase 1	Homo sapiens	0-14
12619037-0	2003	Fhit gene alterations in hepatocarcinogenesis induced by a choline-deficient L-amino acid-defined diet in rats.	Amino Acids	77-89	fragile histidine triad diadenosine triphosphatase	Rattus norvegicus	0-4
12619037-1	2003	Alterations of the fragile histidine triad (Fhit) gene were investigated in rat hepatocarcinogenesis induced by a choline-deficient L-amino acid-defined (CDAA) diet.	Amino Acids	132-144	fragile histidine triad diadenosine triphosphatase	Rattus norvegicus	44-48
12631327-4	2003	The more efficient putative carrier, AtmBAC1, was expressed in E. coli, purified, and reconstituted into phospholipid vesicles, where it transported the basic l-amino acids arginine, lysine, ornithine and histidine (in order of decreasing affinity).	Amino Acids	159-172	Mitochondrial substrate carrier family protein	Arabidopsis thaliana	37-44
12428172-0	2002	L-amino acid sensing by the calcium-sensing receptor: a general mechanism for coupling protein and calcium metabolism?	Amino Acids	0-12	calcium sensing receptor	Homo sapiens	28-52
12428172-6	2002	New data demonstrating L-amino acid-dependent activation of the calcium-sensing receptor (CaR), which regulates PTH secretion and urinary calcium excretion, suggests an unexpected explanation for these links between calcium and protein metabolism.	Amino Acids	23-35	calcium sensing receptor	Homo sapiens	64-88
12428172-6	2002	New data demonstrating L-amino acid-dependent activation of the calcium-sensing receptor (CaR), which regulates PTH secretion and urinary calcium excretion, suggests an unexpected explanation for these links between calcium and protein metabolism.	Amino Acids	23-35	calcium sensing receptor	Homo sapiens	90-93
12323028-1	2002	Substituted oxazoline amines have been prepared in high yield from beta-amino alcohols and Fmoc-protected alpha-amino acids using CCl(4), PPh(3), and Hunig"s base in a one-pot procedure followed by base-mediated deprotection.	Amino Acids	106-123	caveolin 1	Homo sapiens	138-143
12207886-8	2002	The human NOT3 (hNOT3L), which we identified, has an extra 144 amino acids (AAs) at the C-terminus of a classical NOT3.	Amino Acids	76-79	CCR4-NOT transcription complex subunit 3	Homo sapiens	10-14
12207886-8	2002	The human NOT3 (hNOT3L), which we identified, has an extra 144 amino acids (AAs) at the C-terminus of a classical NOT3.	Amino Acids	76-79	CCR4-NOT transcription complex subunit 3	Homo sapiens	17-21
11894099-8	2002	We demonstrate that T1R1 and T1R3 combine to function as a broadly tuned L-amino-acid sensor responding to most of the 20 standard amino acids, but not to their D-enantiomers or other compounds.	Amino Acids	73-85	taste 1 receptor member 1	Homo sapiens	20-24
11894099-8	2002	We demonstrate that T1R1 and T1R3 combine to function as a broadly tuned L-amino-acid sensor responding to most of the 20 standard amino acids, but not to their D-enantiomers or other compounds.	Amino Acids	73-85	taste 1 receptor member 3	Homo sapiens	29-33
11872629-1	2002	Expression of cyclooxygenase (COX)-2 protein during rat hepatocarcinogenesis associated with fatty change, fibrosis, cirrhosis and oxidative DNA damage, caused by a choline-deficient, L-amino acid-defined (CDAA) diet were investigated in F344 male rats, along with the chemopreventive efficacy of the specific COX-2 inhibitor, nimesulide (NIM).	Amino Acids	184-196	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	14-36
11856002-3	2002	Oxidation of the metal carbene moiety followed by basic hydrolysis of the esters afforded enantiomerically highly enriched syn,exo-3,4,5-trisubstituted prolines, whereas acidic hydrolysis of the same functional groups proceeded with epimerization at the alpha-amino acid center leading to anti,exo-3,4,5-trisubstituted prolines of very high enantiomeric purity as well.	Amino Acids	254-270	synemin	Homo sapiens	123-126
12120387-0	2002	Deracemisation and stereoinversion of alpha-amino acids using D-amino acid oxidase and hydride reducing agents.	Amino Acids	38-55	D-amino acid oxidase	Homo sapiens	62-82
12068492-0	2002	[The prolonged action of an insulin peptidomimetic by the substitution of L-amino acid for its D-isomer].	Amino Acids	74-86	insulin	Homo sapiens	28-35
11872629-0	2002	Increased expression of cyclooxygenase-2 protein during rat hepatocarcinogenesis caused by a choline-deficient, L-amino acid-defined diet and chemopreventive efficacy of a specific inhibitor, nimesulide.	Amino Acids	112-124	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	24-40
11779115-7	2002	Using this assay, we have demonstrated that a peptide with a nonhydrolyzable beta-amino acid substitution binds DM2 with an affinity comparable to a p53 peptide that is composed of only alpha-amino acids.	Amino Acids	186-203	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	112-115
11779115-7	2002	Using this assay, we have demonstrated that a peptide with a nonhydrolyzable beta-amino acid substitution binds DM2 with an affinity comparable to a p53 peptide that is composed of only alpha-amino acids.	Amino Acids	186-203	tumor protein p53	Homo sapiens	149-152
11535050-1	2001	The ligand-binding domain (LBD) of the human androgen receptor (hAR LBD), encompassing amino acids (AAs) 647-919, was expressed in Escherichia coli with an N-terminal polyhistidine tag (His(10)-hAR LBD) from a pET-16b vector.	Amino Acids	100-103	androgen receptor	Homo sapiens	45-62
11591158-4	2001	Transport studies in Xenopus laevis oocytes revealed that hCAT-3 is selective for cationic L-amino acids and exhibits a maximal transport activity similar to other CAT proteins.	Amino Acids	91-104	solute carrier family 7 member 3	Homo sapiens	58-64
11591158-6	2001	This is in contrast to rat and murine CAT-3 proteins that have been reported to display a very low activity and to be inhibited by neutral and anionic L-amino acids as well as D-arginine (Hosokawa, H., et al.	Amino Acids	151-164	dominant cataract 3	Mus musculus	38-43
11535050-1	2001	The ligand-binding domain (LBD) of the human androgen receptor (hAR LBD), encompassing amino acids (AAs) 647-919, was expressed in Escherichia coli with an N-terminal polyhistidine tag (His(10)-hAR LBD) from a pET-16b vector.	Amino Acids	100-103	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	64-67
11592401-9	2001	Among other tasks, we performed a systematic D-amino acid scan of uPA19-31, in which each of the 13 L-amino acids was individually substituted by the corresponding D-amino acid.	Amino Acids	100-113	plasminogen activator, urokinase	Homo sapiens	66-74
11342555-1	2001	An HLA-B27-restricted self-octapeptide known to react with an alloreactive T-cell receptor has been modified by systematic substitution of a beta-amino acid for the natural alpha-amino acid residue, over the whole length of the parent epitope.	Amino Acids	173-189	major histocompatibility complex, class I, B	Homo sapiens	3-10
11278397-0	2001	Overexpression of LAT1/CD98 light chain is sufficient to increase system L-amino acid transport activity in mouse hepatocytes but not fibroblasts.	Amino Acids	73-85	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	18-22
11278397-0	2001	Overexpression of LAT1/CD98 light chain is sufficient to increase system L-amino acid transport activity in mouse hepatocytes but not fibroblasts.	Amino Acids	73-85	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	Mus musculus	23-27
11258915-3	2001	Biologically active pyrrhocoricin made of L-amino acids diminished the ATPase activity of recombinant DnaK.	Amino Acids	42-55	ATPase	Escherichia coli	71-77
11124260-9	2001	In the neighborhood of the catalytic serine, the orientation of Glu-429, a residue unique to PLAP, and the presence of a hydrophobic pocket close to the phosphate product, account for the specific uncompetitive inhibition of PLAP by l-amino acids, consistent with the acquisition of substrate specificity.	Amino Acids	233-246	alkaline phosphatase, placental	Homo sapiens	93-97
11124260-9	2001	In the neighborhood of the catalytic serine, the orientation of Glu-429, a residue unique to PLAP, and the presence of a hydrophobic pocket close to the phosphate product, account for the specific uncompetitive inhibition of PLAP by l-amino acids, consistent with the acquisition of substrate specificity.	Amino Acids	233-246	alkaline phosphatase, placental	Homo sapiens	225-229
11300861-4	2001	The reactions of 7 with silyl enolates, Danishefsky"s diene, and alkenes also proceeded smoothly in the presence of Sc(OTf)3 (20 mol %) to give the corresponding alpha-amino acid, pyridone, and tetrahydroquinoline derivatives, respectively, in good yields.	Amino Acids	162-178	POU class 5 homeobox 1	Homo sapiens	116-124
11319613-2	2001	AIP has shown structural and functional homology to L-amino acid oxidase (LAO) which oxidizes several L-amino acids including L-lysine and AIP-induced apoptosis has been suggested to be mediated by H2O2 generated by LAO activity of AIP.	Amino Acids	102-115	aryl hydrocarbon receptor interacting protein	Homo sapiens	0-3
11319613-2	2001	AIP has shown structural and functional homology to L-amino acid oxidase (LAO) which oxidizes several L-amino acids including L-lysine and AIP-induced apoptosis has been suggested to be mediated by H2O2 generated by LAO activity of AIP.	Amino Acids	102-115	interleukin 4 induced 1	Homo sapiens	52-72
11319613-2	2001	AIP has shown structural and functional homology to L-amino acid oxidase (LAO) which oxidizes several L-amino acids including L-lysine and AIP-induced apoptosis has been suggested to be mediated by H2O2 generated by LAO activity of AIP.	Amino Acids	102-115	interleukin 4 induced 1	Homo sapiens	74-77
11319613-2	2001	AIP has shown structural and functional homology to L-amino acid oxidase (LAO) which oxidizes several L-amino acids including L-lysine and AIP-induced apoptosis has been suggested to be mediated by H2O2 generated by LAO activity of AIP.	Amino Acids	102-115	aryl hydrocarbon receptor interacting protein	Homo sapiens	139-142
11327829-11	2001	OmpT was highly selective toward L-amino acids at P(1) but was less so at P(1)" where a peptide with D-Arg at P(1)" was a competitive inhibitor (K(i) of 19 microM).	Amino Acids	33-46	outer membrane protease	Escherichia coli	0-4
11319613-2	2001	AIP has shown structural and functional homology to L-amino acid oxidase (LAO) which oxidizes several L-amino acids including L-lysine and AIP-induced apoptosis has been suggested to be mediated by H2O2 generated by LAO activity of AIP.	Amino Acids	102-115	aryl hydrocarbon receptor interacting protein	Homo sapiens	139-142
10711446-3	2000	Administration of a choline-deficient L-amino acid-defined (CDAA) diet for six weeks with pig serum coadministration, after pretreatment with pig serum for eight weeks, led to the development of preneoplastic lesions that were positive for the placental form of glutathione S-transferase (GSTP).	Amino Acids	38-50	hematopoietic prostaglandin D synthase	Rattus norvegicus	262-287
10861956-0	2000	Chiral discrimination of N-carbazole-carbonyl derivatives of alpha-amino acids with a short linear alkyl side chain by bovine serum albumin.	Amino Acids	61-78	albumin	Homo sapiens	126-139
10781086-7	2000	l-amino acid mixtures emulating the amino acid composition of fasting human plasma reproduced the effects of high concentrations of individual l-amino acids on Ca(2+) mobilization and enhanced the sensitivity of the CaR to Ca(2+)(o).	Amino Acids	0-12	CXADR pseudogene 1	Homo sapiens	216-219
10781086-8	2000	The data presented herein identify the CaR as a molecular target for aromatic and other l-amino acids.	Amino Acids	88-101	CXADR pseudogene 1	Homo sapiens	39-42
10781086-10	2000	The actions of l-amino acids on the CaR may provide explanations for several long recognized but poorly understood actions of dietary protein on calcium metabolism.	Amino Acids	15-28	CXADR pseudogene 1	Homo sapiens	36-39
10711446-3	2000	Administration of a choline-deficient L-amino acid-defined (CDAA) diet for six weeks with pig serum coadministration, after pretreatment with pig serum for eight weeks, led to the development of preneoplastic lesions that were positive for the placental form of glutathione S-transferase (GSTP).	Amino Acids	38-50	glutathione S-transferase pi 1	Rattus norvegicus	289-293
10693655-2	2000	The synthesis of the target compounds was accomplished by coupling of the appropriate TSAO intermediate with a conveniently protected (L) amino acid in the presence of BOP and triethylamine, followed by deprotection of the amino acid moiety.	Amino Acids	134-148	BOP	Homo sapiens	168-171
10525090-11	1999	Our results suggest that L-valine is a desirable L-amino acid for the esterification of poorly permeable drugs to enhance their oral bioavailability targeting intestinal PEPT1.	Amino Acids	49-61	solute carrier family 15 member 1	Rattus norvegicus	170-175
10498197-1	1999	Potent and selective thrombin inhibitors have been prepared with a piperazinedione template and L-amino acids.	Amino Acids	96-109	coagulation factor II, thrombin	Homo sapiens	21-29
10446371-1	1999	The enantioselective binding sites on bovine serum albumin were examined by HPLC using 19 racemic 5-N, N-dimethylamino-1-naphthalenesulfonyl derivatives of alpha-amino acids (dansyl amino acids) as chiral probes.	Amino Acids	156-173	albumin	Homo sapiens	45-58
10551317-1	1999	We have investigated aberrant methylation of CpG nucleotides (CpG sites) and gene expression of c-myc during hepatocarcinogenesis induced by a choline-deficient, L-amino acid-defined (CDAA) diet in rats.	Amino Acids	162-174	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	96-101
10463579-0	1999	Different frequencies and patterns of beta-catenin mutations in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats.	Amino Acids	147-159	catenin beta 1	Rattus norvegicus	38-50
10439935-3	1999	It has been shown to improve the clinical benefits of levodopa plus an aromatic L-amino acid decarboxylase inhibitor (AADC) when given to patients with Parkinson"s disease and end-of-dose deterioration in the response to levodopa (the "wearing off" phenomenon).	Amino Acids	80-92	dopa decarboxylase	Homo sapiens	118-122
9794908-2	1998	Administration of a choline deficient L-amino acid defined (CDAA) diet for 6 weeks with or without pig serum pretreatment led to the development of preneoplastic lesions that were positive for the placental form of glutathione S-transferase (GSTP).	Amino Acids	38-50	hematopoietic prostaglandin D synthase	Rattus norvegicus	215-240
10393704-4	1999	Conversion of alpha-amino acids to aldehydes requires hypochlorous acid (HOCl), formed from H2O2 and chloride by myeloperoxidase.	Amino Acids	14-31	myeloperoxidase	Homo sapiens	113-128
10026178-5	1999	A systematic replacement with L-amino acids within the peptide representing the putative VEGF-binding site on VEGFR II indicates Asp255 as the hydrophilic key residue for binding.	Amino Acids	30-43	vascular endothelial growth factor A	Homo sapiens	89-93
9987991-1	1999	The neutral and basic amino acid transporter (NBAT) facilitates sodium-independent transport of L-amino acids in renal and intestinal epithelial cells and has been postulated to play a similar role in neurons.	Amino Acids	96-109	solute carrier family 3 member 1	Rattus norvegicus	46-50
9927626-2	1999	Yet the substitution of any one of three L-amino acids by their D-enantiomers conferred on this peptide a potent antiangiogenic activity approaching that of the intact 450-kDa TSP-1.	Amino Acids	41-54	thrombospondin 1	Mus musculus	176-181
9822825-3	1998	Unexpectedly, most other naturally occurring L-amino acids found in proteins (with the exception of proline, lysine, arginine and histidine) have the same effect on the expression of BAP3.	Amino Acids	45-58	amino acid transporter BAP3	Saccharomyces cerevisiae S288C	183-187
9706043-10	1998	CONCLUSIONS: This study demonstrates that L-amino acid-nucleoside chimeras can serve as prodrugs to enhance intestinal absorption via the PEPT1 transporter, providing a novel strategy for improving oral therapy of nucleoside drugs.	Amino Acids	42-54	solute carrier family 15 member 1	Homo sapiens	138-143
9578573-0	1998	Human neutrophils employ myeloperoxidase to convert alpha-amino acids to a battery of reactive aldehydes: a pathway for aldehyde generation at sites of inflammation.	Amino Acids	52-69	myeloperoxidase	Homo sapiens	25-40
9578573-2	1998	We now present evidence for the generality of this reaction by demonstrating that neutrophils employ the myeloperoxidase-H2O2-Cl- system to oxidize nearly all of the common alpha-amino acids to yield a family of reactive aldehydes.	Amino Acids	173-190	myeloperoxidase	Homo sapiens	105-120
9578573-7	1998	Stimulated human neutrophils likewise generated aldehydes from all classes of alpha-amino acids by a pathway inhibited by heme poisons and catalase, implicating myeloperoxidase and H2O2 in the cell-mediated reaction.	Amino Acids	78-95	catalase	Homo sapiens	139-147
9578573-7	1998	Stimulated human neutrophils likewise generated aldehydes from all classes of alpha-amino acids by a pathway inhibited by heme poisons and catalase, implicating myeloperoxidase and H2O2 in the cell-mediated reaction.	Amino Acids	78-95	myeloperoxidase	Homo sapiens	161-176
8185660-0	1994	Pharmacological characterization of linear analogues of vasopressin generated by the systematic substitution of positions 1 and 6 by L-amino acids.	Amino Acids	133-146	arginine vasopressin	Homo sapiens	56-67
8788130-1	1995	A thermospray liquid chromatography/mass spectrometry (TSP-LC/MS) method is described for determination of the enantiomeric excess of alpha-amino acids and alpha-amino acid amides as their o-phthalaldehyde/N-acetyl-L-cysteine (OPA/NAC) derivatives.	Amino Acids	134-151	synuclein alpha	Homo sapiens	231-234
8788130-3	1995	On-column mass spectra were acquired for the OPA/NAC derivatives of several alpha-amino acids and alpha-amino acid amides.	Amino Acids	76-93	synuclein alpha	Homo sapiens	45-52
7492656-5	1995	These results show that insulin has a beneficial effect on the preimplantation development of bovine embryos in the presence of AAs and/or glucose, and suggest that insulin improves embryonic development by stimulating AAs transport and/or glucose uptake.	Amino Acids	128-131	insulin	Bos taurus	24-31
7945233-2	1994	Thermal denaturation of cytochrome c has been studied in the presence of various concentrations of all L-amino acids that are more hydrophobic than glycine and have a solubility of 0.1 M or higher in water at 25 degrees C. The basic observations are as follows.	Amino Acids	103-116	cytochrome c, somatic	Homo sapiens	24-36
9478947-0	1998	Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to oxidize alpha-amino acids to a family of reactive aldehydes.	Amino Acids	90-107	myeloperoxidase	Homo sapiens	29-44
9454596-1	1998	A series of low molecular weight peptide inhibitors of factor Xa, unrelated to any previously described, was identified by screening a combinatorial peptide library composed of L-amino acids.	Amino Acids	177-190	coagulation factor X	Homo sapiens	55-64
10729905-3	1998	The successful transfer of the complex alpha-amino acid homologation reaction sequence into solid-phase chemistry demonstrates the potentials of the Boc-resin for synthesis of peptidomimetics.	Amino Acids	39-55	BOC cell adhesion associated, oncogene regulated	Homo sapiens	149-152
9334213-3	1997	Our results demonstrated that the first 82 amino acids (AAs) (AAs 265-346) of the cytoplasmic domain of the betaL chain are sufficient to activate the Jak-Stat pathway and trigger an antiviral state after IFNalpha2 binding to the receptor.	Amino Acids	56-59	interferon alpha 2	Homo sapiens	205-214
9334213-3	1997	Our results demonstrated that the first 82 amino acids (AAs) (AAs 265-346) of the cytoplasmic domain of the betaL chain are sufficient to activate the Jak-Stat pathway and trigger an antiviral state after IFNalpha2 binding to the receptor.	Amino Acids	62-65	interferon alpha 2	Homo sapiens	205-214
9364001-1	1997	Previously, we have reported that aspirin, a cyclooxygenase (COX) inhibitor, can prevent the fibrosis, cirrhosis and generation of oxidative DNA damage, and the associated development of glutathione-S-transferase placental form (GST-P)-positive preneoplastic liver nodules, caused by a choline-deficient, L-amino acid-defined (CDAA) diet in rats.	Amino Acids	305-317	glutathione S-transferase pi 1	Rattus norvegicus	187-234
9278283-3	1997	The chimeric Pam residue integrates the heterocyclic functionality of pyridoxamine phosphate into the side chain of an alpha-amino acid and was introduced instead of Phe8 into the C-peptide sequence via standard solid phase methodology.	Amino Acids	119-135	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	13-16
8950220-1	1996	Mutations of Ki-ras and p53 genes in hepatocellular carcinomas (HCCs) induced by the choline deficient L-amino acid defined (CDAA) diet in rats were investigated by polymerase chain reaction (PCR), single strand conformation polymorphism (SSCP) analysis followed by direct sequencing.	Amino Acids	103-115	KRAS proto-oncogene, GTPase	Rattus norvegicus	13-19
8755502-11	1996	Therefore, the catalytic sites of D-amino acid oxidase and flavocytochrome b2 appear to have converged to a highly similar but enantiomeric architecture in order to catalvze similar reactions (oxidation of alpha-amino acids or alpha-hydroxy acids), although with opposite stereochemistry.	Amino Acids	206-223	D-amino acid oxidase	Homo sapiens	34-54
8117696-5	1994	This is the first documentation of bradykinin binding and functional antagonist activity by a bradykinin peptide analogue with an L amino acid replacing Pro7.	Amino Acids	130-142	kininogen 1	Homo sapiens	35-45
7511662-1	1994	Substitution with all naturally occurring L-amino acids at each of 11 residues of the IEk-restricted month cytochrome c (93-103) epitope has allowed us to analyze the requirements for MHC binding and T cell recognition to a level of definition not previously possible.	Amino Acids	42-55	cytochrome c, somatic	Homo sapiens	107-119
8117696-5	1994	This is the first documentation of bradykinin binding and functional antagonist activity by a bradykinin peptide analogue with an L amino acid replacing Pro7.	Amino Acids	130-142	kininogen 1	Homo sapiens	94-104
8228989-10	1993	The data suggest that the natural substrate of glutamine transaminase K in rat brain is indeed glutamine and that the metabolism of glutamine through the glutaminase II pathway (i.e., L-glutamine and alpha-keto acid-->alpha-ketoglutarate and L-amino acid + ammonia) is an important function of the choroid plexus.	Amino Acids	245-257	kynurenine aminotransferase 1	Rattus norvegicus	47-71
8482390-4	1993	Besides cleaving this standard substrate, aminopeptidase yscXVI acts on several other 4-nitroanilide substrates with unsubstituted N-terminal L-amino acids.	Amino Acids	142-155	aminopeptidase	Saccharomyces cerevisiae S288C	42-56
1376926-8	1992	(iii) The stimulation of sodium-independent uptake of L-arginine and the stimulation of sodium-dependent uptake of L-leucine induced by injection of 4F2hc cRNA are both completely inhibited by dibasic L amino acids and to a lesser extent by D-ornithine.	Amino Acids	201-214	solute carrier family 3 member 2	Homo sapiens	149-154
1284246-1	1992	A cDNA encoding the complete amino acid sequence of aminoacylase 1 (N-acylamino acid aminohydrolase, ACY-1) [EC 3.5.1.14], a dimeric metalloprotein having two Zn2+ in the molecule, which catalyzes the deacylation of N-acylated L-amino acids except L-aspartic acid, has been isolated from porcine kidney lambda gt10 cDNA library and sequenced.	Amino Acids	227-240	aminoacylase 1	Homo sapiens	52-66
1284246-1	1992	A cDNA encoding the complete amino acid sequence of aminoacylase 1 (N-acylamino acid aminohydrolase, ACY-1) [EC 3.5.1.14], a dimeric metalloprotein having two Zn2+ in the molecule, which catalyzes the deacylation of N-acylated L-amino acids except L-aspartic acid, has been isolated from porcine kidney lambda gt10 cDNA library and sequenced.	Amino Acids	227-240	aminoacylase 1	Homo sapiens	101-106
24178194-1	1992	An L-amino-acid oxidase (EC 1.4.3.1) that catalyzes the oxidative deamination of twelve L-amino acids has been purified 21-fold and with 14% yield to electrophoretic homogeneity from Chlamydomonas reinhardtii cells by ammonium-sulfate fractionation, gel filtration through Sephacryl and Superose, anion-exchange chromatography and preparative electrophoresis in polyacrylamide gels.	Amino Acids	88-101	uncharacterized protein	Chlamydomonas reinhardtii	3-23
24178194-5	1992	Apparent K m values of the twelve L-amino acids which can act as substrates of L-amino-acid oxidase ranged between 31 muM for phenylalanine and 176 muM for methionine.	Amino Acids	34-47	uncharacterized protein	Chlamydomonas reinhardtii	79-99
2045937-0	1991	Brain and brain tumor uptake of L-3-[123I]iodo-alpha-methyl tyrosine: competition with natural L-amino acids.	Amino Acids	95-108	immunoglobulin kappa variable 2-14 (pseudogene)	Homo sapiens	32-35
1730059-4	1992	Since the turnover rates of L-serine-induced and D-serine-induced intestinal ODC protein were the same as the non-induced control, we concluded that the induction by glycine and L-amino acids was brought about by an increased efficiency of translation of the ODC message.	Amino Acids	178-191	ornithine decarboxylase 1	Rattus norvegicus	77-80
1730059-4	1992	Since the turnover rates of L-serine-induced and D-serine-induced intestinal ODC protein were the same as the non-induced control, we concluded that the induction by glycine and L-amino acids was brought about by an increased efficiency of translation of the ODC message.	Amino Acids	178-191	ornithine decarboxylase 1	Rattus norvegicus	259-262
1385043-2	1992	The minimal common sequence for mAb recognition is GVxLxD in the S-antigen/hTNF alpha amino acid (aa) sequences.	Amino Acids	80-96	tumor necrosis factor	Homo sapiens	75-79
33590844-2	2021	We previously found that L-amino acid oxidase encoded by the Lao1 gene, exerts biological roles in the mammary gland and brain by converting specific L-amino acids into keto acids, ammonia, and hydrogen peroxide (H2O2).	Amino Acids	150-163	interleukin 4 induced 1B	Mus musculus	25-45
1693780-4	1990	Spantide II, an undecapeptide, has a total of seven substitutions in the sequence of substance P, consisting of two natural L amino acids, and one unnatural L amino acid, and four unnatural D amino acids.	Amino Acids	124-137	tachykinin precursor 1	Homo sapiens	85-96
16748663-0	1950	The oxidation of various synthetic alpha-amino-acids by mammalian d-amino-acid oxidase, l-amino-acid oxidase of cobra venom and the l- and d-amino-acid oxidases of Neurospora crassa.	Amino Acids	35-52	interleukin 4 induced 1	Homo sapiens	88-108
33590844-2	2021	We previously found that L-amino acid oxidase encoded by the Lao1 gene, exerts biological roles in the mammary gland and brain by converting specific L-amino acids into keto acids, ammonia, and hydrogen peroxide (H2O2).	Amino Acids	150-163	L-amino acid oxidase 1	Mus musculus	61-65
34471403-7	2021	The P-I metalloproteinases were characterized by azocaseinolytic, fibrinogenolytic and gelatinase activity and LAAO activity was assessed by enzyme activity on L-amino acids.	Amino Acids	160-173	interleukin 4 induced 1	Mus musculus	111-115
33825470-7	2021	We show that the HRC peptide backbone can be modified via partial replacement of alpha-amino acid residues with beta-amino acid residues to generate alpha/beta-peptides that retain antiviral activity but are poor protease substrates.	Amino Acids	81-97	histidine rich calcium binding protein	Homo sapiens	17-20
34811892-1	2022	A controllable and regiodivergent N -allylation reaction involving readily available O -alkyl hydroxamates derived from natural alpha-amino acids has been developed, allowing regiospecific access to alpha/beta-dipeptides containing alpha-unsaturated beta-amino acids moieties in moderate to good yields.	Amino Acids	128-145	amyloid beta precursor protein	Homo sapiens	0-1
34811892-1	2022	A controllable and regiodivergent N -allylation reaction involving readily available O -alkyl hydroxamates derived from natural alpha-amino acids has been developed, allowing regiospecific access to alpha/beta-dipeptides containing alpha-unsaturated beta-amino acids moieties in moderate to good yields.	Amino Acids	128-145	amyloid beta precursor protein	Homo sapiens	199-209
34846860-1	2021	Three disulfide bond-containing peptide amphiphiles (PA1-3) with different lengths of alkyl tails (PA1 for C6, PA2 for C12, and PA3 for C18) were synthesized by ring-opening polymerization of alpha-amino acid N-carboxyanhydride followed by post-polymerization modification.	Amino Acids	192-208	PAXIP1 associated glutamate rich protein 1	Homo sapiens	53-56
34265467-7	2021	Another function of v-ATPase involves binding of anabolic master-regulator mTORC1 to endosomes, a prerequisite for activation of mTORC1 by amino acids (AAs).	Amino Acids	152-155	CREB regulated transcription coactivator 1	Mus musculus	75-81
34265467-7	2021	Another function of v-ATPase involves binding of anabolic master-regulator mTORC1 to endosomes, a prerequisite for activation of mTORC1 by amino acids (AAs).	Amino Acids	152-155	CREB regulated transcription coactivator 1	Mus musculus	129-135
34467854-4	2021	We used a negative allosteric nanobody to stabilize the CaSR in the fully inactive state and found a new binding site for Ca2+ ion that acts as a composite agonist with L-amino acid to stabilize the closure of active Venus flytraps.	Amino Acids	169-181	calcium sensing receptor	Homo sapiens	56-60
34467854-6	2021	Our results reveal the structural basis for activation mechanisms of CaSR and clarify the mode of action of Ca2+ ions and L-amino acid leading to the activation of the receptor.	Amino Acids	122-134	calcium sensing receptor	Homo sapiens	69-73
34471403-11	2021	LAAO showed differential activity on L-amino acids.	Amino Acids	37-50	interleukin 4 induced 1	Mus musculus	0-4
4027591-1	1985	An extended baseline characterization of amino acids (AAs) and related amino compounds in CSF is reported.	Amino Acids	54-57	colony stimulating factor 2	Homo sapiens	90-93
35359116-1	2022	In this study, the transformation of five amino acids (AAs), i.e., glycine (GLY), alanine (ALA), serine (SER), aspartic acid (ASP), and methionine (MET), in a heat activated peroxydisulfate (PDS) oxidation process was investigated.	Amino Acids	55-58	SAFB like transcription modulator	Homo sapiens	148-151
2673694-7	1989	Glucagon, alpha-amino acid nitrogen, and lactate concentrations were exquisitely sensitive to a rise in glucose and insulin concentrations.	Amino Acids	10-26	insulin	Homo sapiens	116-123
3555499-0	1987	Potent GnRH agonists containing L-amino acid derivatives in the six position.	Amino Acids	32-44	gonadotropin releasing hormone 1	Rattus norvegicus	7-11
3555499-2	1987	We now report a series of L-beta-aspartyl-6 GnRH analogs containing only naturally occurring L-amino acids in the whole sequence, exhibiting considerable in vivo biological activity.	Amino Acids	93-106	gonadotropin releasing hormone 1	Rattus norvegicus	44-48
3025541-0	1987	Angiotensin I converting enzyme inhibitors containing unnatural alpha-amino acid analogues of phenylalanine.	Amino Acids	64-80	angiotensin I converting enzyme	Rattus norvegicus	0-31
2878001-1	1986	The deamination of L-amino acids by L-amino acid oxidase, which creates a change in the ionic strength of an HPLC eluent, is used to allow conductometric detection of L-amino acids.	Amino Acids	19-32	interleukin 4 induced 1	Homo sapiens	36-56
2878001-1	1986	The deamination of L-amino acids by L-amino acid oxidase, which creates a change in the ionic strength of an HPLC eluent, is used to allow conductometric detection of L-amino acids.	Amino Acids	167-180	interleukin 4 induced 1	Homo sapiens	36-56
34106313-3	2021	LAAO catalyzes the oxidative deamination of specific L-amino acids with the generation of hydrogen peroxide and L-amino acid metabolites.	Amino Acids	53-66	interleukin 4 induced 1	Homo sapiens	0-4
34106313-3	2021	LAAO catalyzes the oxidative deamination of specific L-amino acids with the generation of hydrogen peroxide and L-amino acid metabolites.	Amino Acids	112-124	interleukin 4 induced 1	Homo sapiens	0-4
34222079-1	2021	Background: Amino acids (AAs) and acylcarnitines play a key role in metabolic disease and can be used as biomarkers of various diseases such as malignancies, type 2 diabetes (T2D), insulin resistance, and cardiovascular diseases, therefore, designing an accurate and simple laboratory method that simultaneously measure both groups of substances, could improve the process of analytes quantification.	Amino Acids	25-28	insulin	Homo sapiens	181-188
35526712-2	2022	The highest VFAs yields of 0.71 and 0.72 mg COD/mg CODsubstrate both occurred at Car/Pro ratio of 1 by BSA-dextran and amino acids (AAs)-glucose fermentation, respectively.	Amino Acids	132-135	CXADR pseudogene 1	Homo sapiens	81-84
35516840-0	2022	CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet.	Amino Acids	164-176	CD44 molecule (Indian blood group)	Rattus norvegicus	0-4
3031217-3	1987	Incubation of slices with m-ENK (1-10 microM) increased the basal release of Tyr (up to 293% of control) from CS, but not Cx, whereas other nonneurotransmitter AAs, phenylalanine (Phe) and valine (Val), were unchanged.	Amino Acids	160-163	proopiomelanocortin	Homo sapiens	26-31
3031217-4	1987	The release of the putative neurotransmitter AAs glutamate (Glu), taurine (Tau), and glycine (Gly) were similarly increased by 50-150% with m-ENK in slices of CS, but not Cx.	Amino Acids	45-48	proopiomelanocortin	Homo sapiens	140-145
3031217-5	1987	The enhanced release of AAs by m-ENK was prevented by removal of extracellular Ca2+ or by preincubation with the opiate receptor antagonist naloxone.	Amino Acids	24-27	proopiomelanocortin	Homo sapiens	31-36
4027591-5	1985	Conjugated AAs were determined as the difference between levels of free AAs (measured in CSF prior to hydrolysis) and total AAs (measured in hydrolyzed CSF) and are taken as an index of total CSF peptide AAs.	Amino Acids	72-75	colony stimulating factor 2	Homo sapiens	89-92
4027591-5	1985	Conjugated AAs were determined as the difference between levels of free AAs (measured in CSF prior to hydrolysis) and total AAs (measured in hydrolyzed CSF) and are taken as an index of total CSF peptide AAs.	Amino Acids	72-75	colony stimulating factor 2	Homo sapiens	89-92
4027591-6	1985	Results documented conjugated forms of all non-acid-labile CSF AAs except citrulline and ethanolamine.	Amino Acids	63-66	colony stimulating factor 2	Homo sapiens	59-62
2859987-7	1985	Substitution in GRF (or its N-acetylated derivative) by D-Phe2, D-Arg2, and D-Ala4 again reduced the intrinsic activity, whereas substitution of the natural L-amino acid residue by D-Ala2 and Phe4 gave superagonists.	Amino Acids	157-169	growth hormone releasing hormone	Rattus norvegicus	16-19
259497-1	1978	A number of copoly(alpha-amino acids) have been prepared thermally; some have been found to function as inhibitors of glyoxalase I, an enzyme which occupies a central position in Szent-Gyorgyi"s theory of tumour genesis.	Amino Acids	19-36	glyoxalase I	Homo sapiens	118-130
3002335-4	1985	Compounds which contain heteroatoms at two adjacent carbon atoms such as alpha-amino acids, peptides, EDTA and o-phenanthroline are shown to inhibit the phosphatase reaction of glyceraldehyde-3-phosphate dehydrogenase.	Amino Acids	73-90	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	177-217
6754570-1	1982	Substitution of A1-glycine of insulin by L-amino acids yields in analogues with low biological activity.	Amino Acids	41-54	insulin	Bos taurus	30-37
488107-4	1979	On the basis of this finding, we postulate the existence of an abnormal reaction of glutamate decarboxylase in which the proton at C-4 of (S)-4-aminohex-5-ynoic acid is removed in a manner similar to the one which normally occurs in enzymatic transaminations of L-amino acids.	Amino Acids	262-275	glutamate-ammonia ligase	Homo sapiens	84-107
724799-5	1978	On the other hand, D-aspartate oxidase from beef kidney (active on 4C to 6C dicarboxylic alpha-aminoacids) cannot oxidize the 7C alpha-aminopimelic acid but is active on the S-carboxyethyl-D-cysteine analogue.	Amino Acids	89-105	D-aspartate oxidase	Homo sapiens	19-38
836797-1	1977	Pulsed Fourier transform proton magnetic resonance was used to study the labilization of protons of various L-amino acids by the enzyme gamma-cystathionase.	Amino Acids	108-121	cystathionine gamma-lyase	Homo sapiens	136-155
198404-3	1977	Systematic substitution of the natural L-amino acids in neurotensin by their D isomers reveals that the COOH-terminal portion of this tridecapeptide is required for binding to mast cell receptors: D-amino acid replacements from Pro10 through Leu13 substantially decrease that binding.	Amino Acids	39-52	neurotensin	Homo sapiens	56-67
301990-2	1977	Although p29 and p34 have different amino-terminal sequences, their tyrosine peptide maps indicate considerable similarity in other portions of their polypeptide chains.	Amino Acids	36-41	SYF2 pre-mRNA splicing factor	Homo sapiens	9-12
301990-2	1977	Although p29 and p34 have different amino-terminal sequences, their tyrosine peptide maps indicate considerable similarity in other portions of their polypeptide chains.	Amino Acids	36-41	alpha and gamma adaptin binding protein	Homo sapiens	17-20
836797-3	1977	It was found that gamma-cystathionase also catalyzes the exchange of the alpha and beta protons of L-amino acids which cannot undergo elimination reactions, but are competitive inhibitors of the enzyme.	Amino Acids	99-112	cystathionine gamma-lyase	Homo sapiens	18-37
300597-0	1977	[Genetic control of the H-2 region of the cell surface: cationic amino groups in the periphery of T lymphocytes].	Amino Acids	65-70	histocompatibility-2, MHC	Mus musculus	24-27
300597-6	1977	The difference in the number of cationogenic amino-groups in the cell periphery contributing a positive charge, would explain the oberved difference in the EPM of H-2f and H-2s spleen T lymphocytes, and suggest that the macromolecules coded by the H-2 genes or other genes under H-2 control lead to delicate differences in the chemical composition of the surface membranes of cells of the two H-2 haplotypes, expressed only on high EPM lymphocytes of spleen (T or T-like cells).	Amino Acids	45-50	histocompatibility-2, MHC	Mus musculus	163-166
300597-6	1977	The difference in the number of cationogenic amino-groups in the cell periphery contributing a positive charge, would explain the oberved difference in the EPM of H-2f and H-2s spleen T lymphocytes, and suggest that the macromolecules coded by the H-2 genes or other genes under H-2 control lead to delicate differences in the chemical composition of the surface membranes of cells of the two H-2 haplotypes, expressed only on high EPM lymphocytes of spleen (T or T-like cells).	Amino Acids	45-50	histocompatibility-2, MHC	Mus musculus	172-175
300597-6	1977	The difference in the number of cationogenic amino-groups in the cell periphery contributing a positive charge, would explain the oberved difference in the EPM of H-2f and H-2s spleen T lymphocytes, and suggest that the macromolecules coded by the H-2 genes or other genes under H-2 control lead to delicate differences in the chemical composition of the surface membranes of cells of the two H-2 haplotypes, expressed only on high EPM lymphocytes of spleen (T or T-like cells).	Amino Acids	45-50	histocompatibility-2, MHC	Mus musculus	172-175
5355880-0	1969	[Incorporation of l-aminoacids-C 14 into the rat pituitary following surgical stress].	Amino Acids	18-30	anti-Mullerian hormone receptor type 2	Rattus norvegicus	31-35
1148200-2	1975	Human liver alanine aminopeptidase is inhibited by L-amino acids having hydrophobic side chains such as Phe, Tyr, Trp, Met, and Leu.	Amino Acids	51-64	carboxypeptidase Q	Homo sapiens	20-34
33831352-2	2021	Amino acids (AAs) are key upstream signals for mammalian TOR activation, but how nitrogen-related nutrients regulate TOR signaling in plants is poorly understood.	Amino Acids	13-16	target of rapamycin	Arabidopsis thaliana	57-60
4963444-1	1967	The aminopeptidase specificity of 24 strains of bacteria was determined fluorometrically by use of a series of alpha-amino acid beta-naphthylamides as substrates.	Amino Acids	111-127	carboxypeptidase Q	Homo sapiens	4-18
34003553-2	2021	In particular, KRAS mutant cancer cells exploit amino acids (AAs) such as glutamine and leucine, to accelerate energy metabolism, redox balance through glutathione (GSH) synthesis and macromolecule biosynthesis.	Amino Acids	61-64	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	15-19
33630415-4	2022	In diabetes and obesity, KPTCs are exposed to nutrient overload, including glucose, free-fatty acids (FFAs) and amino acids (AAs), which dysregulate nutrient and energy sensing by mTORC1 and AMPK, with subsequent induction of tubular injury, inflammation and fibrosis.	Amino Acids	125-128	CREB regulated transcription coactivator 1	Mus musculus	180-186
33921149-2	2021	Previous metabolomic studies showed a positive association of diabetes and insulin resistance with branched-chain amino acids (AAs) and aromatic AAs.	Amino Acids	127-130	insulin	Homo sapiens	75-82
33730578-2	2021	Recent evidence indicates that Rab1A is essential for amino acids (aas) sensing and signaling to regulate mTORC1 in normal and cancer cells.	Amino Acids	67-70	RAB1A, member RAS oncogene family	Mus musculus	31-36
33730578-2	2021	Recent evidence indicates that Rab1A is essential for amino acids (aas) sensing and signaling to regulate mTORC1 in normal and cancer cells.	Amino Acids	67-70	CREB regulated transcription coactivator 1	Mus musculus	106-112
33603117-3	2021	Aliphatic and aromatic L-amino acids, such as L-Phe and L-Trp, increase the sensitivity of CaSR towards Ca2+ and are considered allosteric activators.	Amino Acids	23-36	calcium sensing receptor	Homo sapiens	91-95
33630415-4	2022	In diabetes and obesity, KPTCs are exposed to nutrient overload, including glucose, free-fatty acids (FFAs) and amino acids (AAs), which dysregulate nutrient and energy sensing by mTORC1 and AMPK, with subsequent induction of tubular injury, inflammation and fibrosis.	Amino Acids	125-128	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	191-195
33210804-0	2021	General Access to Modified alpha-Amino Acids by Bioinspired Stereoselective gamma-C-H Bond Lactonization.	Amino Acids	27-44	interleukin 2 receptor subunit gamma	Homo sapiens	76-83
33210804-4	2021	The system can efficiently target 1o, 2o and 3o gamma-C-H bonds of alpha-substituted and achiral alpha,alpha-disubstituted alpha-amino acids with outstanding site-selectivity, good to excellent diastereoselectivity and (where applicable) enantioselectivity.	Amino Acids	123-140	interleukin 2 receptor subunit gamma	Homo sapiens	48-55
32822860-3	2020	The determinant of potent antibacterial/antiparasitic activity is the H2O2 byproduct of LAO enzymatic activity that utilizes the l-amino acid as a substrate.	Amino Acids	129-141	interleukin 4 induced 1	Homo sapiens	88-91
33052068-3	2021	The mechanistic target of rapamycin complex 1 (mTORC1) pathway integrates external and internal signals, including those by amino acids (AAs), to promote normal preimplantation development.	Amino Acids	137-140	CREB regulated transcription coactivator 1	Mus musculus	47-53
33170713-1	2020	We report a DNA-compatible photoredox decarboxylative coupling of alpha-amino acids with carbonyl compounds to access DNA-encoded sp3-rich 1,2-amino alcohols.	Amino Acids	66-83	Sp3 transcription factor	Homo sapiens	130-133
32013668-2	2020	While the Sec61-complex facilitates transport of all polypeptides with amino-terminal signal peptides (SP) or SP-equivalent transmembrane helices (TMH), the translocating chain-associated membrane protein (now termed TRAM1) was proposed to support transport of a subset of precursors.	Amino Acids	71-76	SEC61 translocon subunit alpha 1	Homo sapiens	10-15
31972245-0	2020	The amino-terminal region of dense granule protein 6 of Toxoplasma gondii stimulates IFN-gamma production by microglia.	Amino Acids	4-9	interferon gamma	Mus musculus	85-94
33068461-3	2021	APPROACH & RESULTS: Here we demonstrate that hepatic LOXL4 expression was increased during the liver carcinogenesis in mice concomitantly fed a choline-deficient, L-amino acid-defined (CDAA) diet.	Amino Acids	163-175	lysyl oxidase-like 4	Mus musculus	53-58
32683182-0	2020	Synthesis, docking study and inhibitory activity of 2,6-diketopiperazines derived from alpha-amino acids on HDAC8.	Amino Acids	87-104	histone deacetylase 8	Homo sapiens	108-113
33096658-1	2020	Different amino acids (AAs) may exert distinct effects on postprandial glucose and insulin concentrations.	Amino Acids	23-26	insulin	Homo sapiens	83-90
32009193-4	2020	The sensitivity of the sensor was (2.73 +- 0.08) muA muM-1, with a linear range between 5.0 x 10-7 M and 6.0 x 10-6 M, a detection limit of 0.15 muM (9.5 mug L-1), and reproducibility of 6.2% using the same dispersion and 7.1% using three different MWCNTs-BCS dispersions.	Amino Acids	256-259	PWWP domain containing 3A, DNA repair factor	Homo sapiens	53-58
31888393-3	2020	Aiming to develop a peptide able to bind adiponectin receptors and modulate their signalling pathways, a 12-amino acid sequence homologous in AdipoR1/R2 has been targeted by phage display with a linear 12-mer peptide library.	Amino Acids	105-118	adiponectin, C1Q and collagen domain containing	Mus musculus	41-52
31888393-3	2020	Aiming to develop a peptide able to bind adiponectin receptors and modulate their signalling pathways, a 12-amino acid sequence homologous in AdipoR1/R2 has been targeted by phage display with a linear 12-mer peptide library.	Amino Acids	105-118	adiponectin receptor 1	Mus musculus	142-149
32074073-1	2020	Mitochondrial precursor proteins with amino-terminal presequences are imported via the presequence pathway, utilizing the TIM23 complex for inner membrane translocation.	Amino Acids	38-43	translocase of inner mitochondrial membrane 23	Homo sapiens	122-127
32467152-3	2020	The calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor that responds to multiple endogenous agonists and allosteric modulators, including divalent and trivalent cations, L-amino acids, gamma-glutamyl peptides, polyamines, polycationic peptides, and protons.	Amino Acids	191-204	calcium sensing receptor	Homo sapiens	4-28
32467152-3	2020	The calcium-sensing receptor (CaSR) is a class C G protein-coupled receptor that responds to multiple endogenous agonists and allosteric modulators, including divalent and trivalent cations, L-amino acids, gamma-glutamyl peptides, polyamines, polycationic peptides, and protons.	Amino Acids	191-204	calcium sensing receptor	Homo sapiens	30-34
32467152-7	2020	The CaSR is somewhat unique in possessing multiple ligand binding sites, including at least five putative sites for the "orthosteric" agonist Ca2+ o, an allosteric site for endogenous L-amino acids, two further allosteric sites for small molecules and the peptide PAM, etelcalcetide, and additional sites for other cations and anions.	Amino Acids	184-197	calcium sensing receptor	Homo sapiens	4-8
32492766-3	2020	Loss of Cygb accelerates liver fibrosis and cancer development in mouse models of chronic liver injury including diethylnitrosamine-induced hepatocellular carcinoma, bile duct ligation-induced cholestasis, thioacetamide-induced hepatic fibrosis, and choline-deficient L-amino acid-defined diet-induced non-alcoholic steatohepatitis.	Amino Acids	268-280	cytoglobin	Mus musculus	8-12
31730966-6	2020	The main adsorption mechanism was the complexation between the carboxyl, amino, and hydroxyl groups in MCS-PAA and Pb(II).	Amino Acids	73-78	submaxillary gland androgen regulated protein 3B	Homo sapiens	115-121
31705481-1	2020	Acetaminophen (APAP) induced hepatotoxicity involves activation of c-Jun amino-terminal kinase (JNK), mitochondrial damage and ER stress.	Amino Acids	4-9	jun proto-oncogene	Mus musculus	67-72
31705481-1	2020	Acetaminophen (APAP) induced hepatotoxicity involves activation of c-Jun amino-terminal kinase (JNK), mitochondrial damage and ER stress.	Amino Acids	4-9	mitogen-activated protein kinase 8	Mus musculus	96-99
31705481-2	2020	BGP-15, a hydroximic acid derivative, has been reported to have hepatoprotective effects in APAP overdose induced liver damage.	Amino Acids	10-25	carcinoembryonic antigen-related cell adhesion molecule 1	Mus musculus	0-3
31858375-0	2020	The Amino Terminus of LeuT Changes Conformation in an Environment Sensitive Manner.	Amino Acids	4-9	Leucine transport, high	Homo sapiens	22-26
31916385-0	2020	Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation.	Amino Acids	0-16	mitogen-activated protein kinase 1	Homo sapiens	83-86
31999086-5	2020	Here, we employ the fluorescent unnatural amino acid acridonylalanine (Acd) as a minimally-perturbing probe of the E. coli RecA:LexA complex.	Amino Acids	42-69	DNA repair system	Escherichia coli	128-132
31858961-7	2020	IgG1 target the amino terminal region of alpha enolase, while IgG2 are more restricted to the central portion of the molecule.	Amino Acids	16-21	enolase 1	Homo sapiens	41-54
31987941-1	2020	A high-efficiency graphene oxide-terminated hyperbranched amino polymer-carboxymethyl cellulose ternary nanocomposite (GO-HBP-NH2-CMC) was fabricated for adsorbing heavy metals from aqueous solutions.	Amino Acids	58-63	heme binding protein 1	Homo sapiens	122-125
32077021-1	2020	Pyroligneous acids can be used in herbicides, but the dosage used often more than 1000 kg ha-1.	Amino Acids	0-18	Rho GTPase activating protein 45	Homo sapiens	90-94
31945720-3	2020	The maximum MC-LR adsorption capacity (Langmuir model) of MC-H (37.87 mg/g) was the highest followed by MC-NH2 (29.25 mg/g) and MS-NH2 (23.03 mg/g), because pore structure is partly damaged during amino-functionalization.	Amino Acids	197-202	pro-melanin concentrating hormone	Homo sapiens	58-62
32045605-6	2020	C-terminal part of the amino sequence of Slp2 protein was found to be highly similar to that of the conserved C-terminal region of SlpA protein of L. crispatus Zj001 isolated from pig intestines and CbsA protein of L. crispatus JCM5810 isolated from chicken intestines, and was substantially variable at the N-terminal and middle regions.	Amino Acids	23-28	synaptotagmin like 2	Homo sapiens	41-45
31831844-7	2020	The interaction of CTCF and NPM1c involves the amino terminus of CTCF and the last 50 amino acids of NPM1.	Amino Acids	47-52	CCCTC-binding factor	Homo sapiens	19-23
31831844-7	2020	The interaction of CTCF and NPM1c involves the amino terminus of CTCF and the last 50 amino acids of NPM1.	Amino Acids	47-52	CCCTC-binding factor	Homo sapiens	65-69
31831844-7	2020	The interaction of CTCF and NPM1c involves the amino terminus of CTCF and the last 50 amino acids of NPM1.	Amino Acids	47-52	nucleophosmin 1	Homo sapiens	28-32
32242892-11	2020	Together, these results suggest that the ASCT2 binding site is able to recognize L-amino acids with short, basic side chains, such as the L-DAP derivative beta-N-methylamino-L-Alanine (BMAA), a well-studied neurotoxin.	Amino Acids	81-94	solute carrier family 1 member 5	Homo sapiens	41-46
32239073-2	2020	While beta3-amino acids can be readily prepared from alpha-amino acids via one-carbon homologation, the synthesis of beta2-amino acids generally requires multistep efforts.	Amino Acids	53-70	immunoglobulin kappa variable 2D-28	Homo sapiens	6-11
32148044-2	2020	It is further found that the enantioselective fluorescence responses of the molecular probe in the presence of Mg2+ toward certain amino acids are the opposite of those in the presence of Zn2+, that is, using Mg2+ with a L-amino acid generates much greater fluorescence enhancement than with the corresponding D-amino acid but using Zn2+ with the D-amino acid gives much greater fluorescence than with the L-enantiomer.	Amino Acids	221-233	mucin 7, secreted	Homo sapiens	111-114
32148044-2	2020	It is further found that the enantioselective fluorescence responses of the molecular probe in the presence of Mg2+ toward certain amino acids are the opposite of those in the presence of Zn2+, that is, using Mg2+ with a L-amino acid generates much greater fluorescence enhancement than with the corresponding D-amino acid but using Zn2+ with the D-amino acid gives much greater fluorescence than with the L-enantiomer.	Amino Acids	221-233	mucin 7, secreted	Homo sapiens	209-212
31835924-11	2020	TNBS decreased the expressions of tight junction (TJ) protein (claudin-1, occludin, and zonula occludens-1 (ZO-1)) and increased the expressions of proapoptotic (caspase-1) protein.	Amino Acids	0-4	claudin 1	Rattus norvegicus	63-72
32005517-4	2020	All four peptides significantly enhanced BV2 cell motility and migration, but OPNpt7R, an RGD-containing 7-amino-acid OPN peptide (VPNGRGD), was found to be most potent and its potency was comparable to OPNpt20.	Amino Acids	105-117	secreted phosphoprotein 1	Mus musculus	78-81
31799703-7	2020	We identified a region of 3 amino acids in the gammac intracellular domain that may be critical for receptor stabilization and allow this alternative signaling.	Amino Acids	26-39	interleukin 2 receptor subunit gamma	Homo sapiens	47-53
32246222-8	2020	The results showed that Sf9 lbr contains an Orf of 2040 nucleotides (NTs), which encodes a predicted protein of 679 amino acids (AAs).	Amino Acids	129-132	lamin B receptor	Homo sapiens	28-31
31975003-0	2020	Preparation of ternary amino-functionalized magnetic nano-sized illite-smectite clay for adsorption of Pb(II) ions in aqueous solution.	Amino Acids	23-28	submaxillary gland androgen regulated protein 3B	Homo sapiens	103-109
31975003-1	2020	Ternary amino-functionalized magnetic illite-smectite (AMNI/S) nanocomposites were prepared via integrating two-dimensional illite-smectite nanoflakes (NI/S), magnetite nanoparticles (Fe3O4), and 3-aminopropyltriethoxysilane (APTES).	Amino Acids	8-13	solute carrier family 5 member 5	Homo sapiens	57-61
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	Amino Acids	52-56	tumor necrosis factor	Rattus norvegicus	281-290
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	Amino Acids	52-56	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	302-307
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	Amino Acids	52-56	nitric oxide synthase 2	Rattus norvegicus	309-313
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	Amino Acids	52-56	caspase 1	Rattus norvegicus	368-377
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	Amino Acids	52-56	claudin 1	Rattus norvegicus	426-435
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	Amino Acids	52-56	occludin	Rattus norvegicus	437-445
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	Amino Acids	52-56	tight junction protein 1	Rattus norvegicus	451-455
31997154-0	2020	Tannic Acid Ameliorates STZ-Induced Alzheimer"s Disease-Like Impairment of Memory, Neuroinflammation, Neuronal Death and Modulates Akt Expression.	Amino Acids	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	131-134
31997154-8	2020	STZ promoted an increase in neuronal death and the levels of proinflammatory cytokines (IL-6 and TNF-alpha) and a decrease in Akt and pAkt expression; TA was able to restore these changes.	Amino Acids	151-153	interleukin 6	Rattus norvegicus	88-92
31997154-8	2020	STZ promoted an increase in neuronal death and the levels of proinflammatory cytokines (IL-6 and TNF-alpha) and a decrease in Akt and pAkt expression; TA was able to restore these changes.	Amino Acids	151-153	tumor necrosis factor	Rattus norvegicus	97-106
31997154-8	2020	STZ promoted an increase in neuronal death and the levels of proinflammatory cytokines (IL-6 and TNF-alpha) and a decrease in Akt and pAkt expression; TA was able to restore these changes.	Amino Acids	151-153	AKT serine/threonine kinase 1	Rattus norvegicus	126-129
31835924-11	2020	TNBS decreased the expressions of tight junction (TJ) protein (claudin-1, occludin, and zonula occludens-1 (ZO-1)) and increased the expressions of proapoptotic (caspase-1) protein.	Amino Acids	0-4	occludin	Rattus norvegicus	74-82
31835924-11	2020	TNBS decreased the expressions of tight junction (TJ) protein (claudin-1, occludin, and zonula occludens-1 (ZO-1)) and increased the expressions of proapoptotic (caspase-1) protein.	Amino Acids	0-4	tight junction protein 1	Rattus norvegicus	88-106
31835924-11	2020	TNBS decreased the expressions of tight junction (TJ) protein (claudin-1, occludin, and zonula occludens-1 (ZO-1)) and increased the expressions of proapoptotic (caspase-1) protein.	Amino Acids	0-4	tight junction protein 1	Rattus norvegicus	108-112
31835924-11	2020	TNBS decreased the expressions of tight junction (TJ) protein (claudin-1, occludin, and zonula occludens-1 (ZO-1)) and increased the expressions of proapoptotic (caspase-1) protein.	Amino Acids	0-4	caspase 1	Rattus norvegicus	162-171
32074717-6	2020	Using complimentary deoxyribonucleic acid microarray technology, we found new genes associated with HGF in the stomach cancer cell lines, NUGC-3 and MKN-28, and identified their function within the HGF pathway.	Amino Acids	20-41	hepatocyte growth factor	Homo sapiens	100-103
31721359-3	2020	A 7-amino acid (7A) peptide has been demonstrated to be translated from the sORF in Sca1+ -VPCs in vitro and in vivo.	Amino Acids	2-14	lymphocyte antigen 6 complex, locus A	Mus musculus	84-88
31721359-3	2020	A 7-amino acid (7A) peptide has been demonstrated to be translated from the sORF in Sca1+ -VPCs in vitro and in vivo.	Amino Acids	16-18	lymphocyte antigen 6 complex, locus A	Mus musculus	84-88
31721359-4	2020	The 7A peptide was shown to receive phosphate group from the activated mitogen-activated protein kinase MEKK1 and transfer it to 14-3-3 gamma protein, forming an MEKK1-7A-14-3-3gamma signal pathway downstream VEGF.	Amino Acids	4-6	mitogen-activated protein kinase kinase kinase 1	Mus musculus	104-109
31721359-4	2020	The 7A peptide was shown to receive phosphate group from the activated mitogen-activated protein kinase MEKK1 and transfer it to 14-3-3 gamma protein, forming an MEKK1-7A-14-3-3gamma signal pathway downstream VEGF.	Amino Acids	4-6	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Mus musculus	129-141
31721359-4	2020	The 7A peptide was shown to receive phosphate group from the activated mitogen-activated protein kinase MEKK1 and transfer it to 14-3-3 gamma protein, forming an MEKK1-7A-14-3-3gamma signal pathway downstream VEGF.	Amino Acids	4-6	mitogen-activated protein kinase kinase kinase 1	Mus musculus	162-167
31721359-4	2020	The 7A peptide was shown to receive phosphate group from the activated mitogen-activated protein kinase MEKK1 and transfer it to 14-3-3 gamma protein, forming an MEKK1-7A-14-3-3gamma signal pathway downstream VEGF.	Amino Acids	4-6	vascular endothelial growth factor A	Mus musculus	209-213
31721359-4	2020	The 7A peptide was shown to receive phosphate group from the activated mitogen-activated protein kinase MEKK1 and transfer it to 14-3-3 gamma protein, forming an MEKK1-7A-14-3-3gamma signal pathway downstream VEGF.	Amino Acids	168-170	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	Mus musculus	129-141
31721359-4	2020	The 7A peptide was shown to receive phosphate group from the activated mitogen-activated protein kinase MEKK1 and transfer it to 14-3-3 gamma protein, forming an MEKK1-7A-14-3-3gamma signal pathway downstream VEGF.	Amino Acids	168-170	mitogen-activated protein kinase kinase kinase 1	Mus musculus	162-167
31721359-4	2020	The 7A peptide was shown to receive phosphate group from the activated mitogen-activated protein kinase MEKK1 and transfer it to 14-3-3 gamma protein, forming an MEKK1-7A-14-3-3gamma signal pathway downstream VEGF.	Amino Acids	168-170	vascular endothelial growth factor A	Mus musculus	209-213
31721359-5	2020	The exogenous synthetic 7A peptide could increase Sca1+ -VPCs cell migration, reendothelialization in the femoral artery injury and angiogenesis in hindlimb ischemia.	Amino Acids	24-26	lymphocyte antigen 6 complex, locus A	Mus musculus	50-54
31721359-7	2020	Loss of the endogenous 7A impaired Sca1+ -VPCs cell migration, reendothelialization of the injured femoral artery and angiogenesis in ischemic tissues, which could be partially rescued by the addition of the exogenous 7A/7Ap peptide.	Amino Acids	23-25	lymphocyte antigen 6 complex, locus A	Mus musculus	35-39
31721359-7	2020	Loss of the endogenous 7A impaired Sca1+ -VPCs cell migration, reendothelialization of the injured femoral artery and angiogenesis in ischemic tissues, which could be partially rescued by the addition of the exogenous 7A/7Ap peptide.	Amino Acids	218-220	lymphocyte antigen 6 complex, locus A	Mus musculus	35-39
31721359-13	2020	This peptide could act as phosphate group carrier, forming a novel signal transduction pathway, the MEKK1-7A-14-3-3?	Amino Acids	106-108	mitogen-activated protein kinase kinase kinase 1	Mus musculus	100-105
32074717-6	2020	Using complimentary deoxyribonucleic acid microarray technology, we found new genes associated with HGF in the stomach cancer cell lines, NUGC-3 and MKN-28, and identified their function within the HGF pathway.	Amino Acids	20-41	hepatocyte growth factor	Homo sapiens	198-201
32077291-1	2020	Here we report O-methyl S-aryl thiocarbonates as a versatile esterification reagent for palladium-catalyzed methoxycar-bonylation of arylboronic acid in the presence of copper(I) thiophene-2-carboxylate (CuTC).	Amino Acids	133-149	cutC copper transporter	Homo sapiens	204-208
31699562-2	2020	Size exclusion chromatography showed that high molecular weight polymers were formed in TGase-treated sWPI (WPI treated with superfine grinding), whereas its consumption of free amino groups reached the maximum at grinding 8 h and 10 h. With the milling time extended from 0 to 10 h, particle size of the TGase-crosslinked sWPI gradually increased.	Amino Acids	178-183	transglutaminase 1	Homo sapiens	88-93
31997154-10	2020	Our study highlights that treatment with TA prevents memory deficits and reestablishes Akt and pAkt expression, protecting against neuronal death and neuroinflammation in STZ-induced SDAT in rats.	Amino Acids	41-43	AKT serine/threonine kinase 1	Rattus norvegicus	87-90
31939666-0	2020	Cu-Catalyzed Generation of Alkyl Radicals from Alkylsilyl Peroxides and Subsequent C(sp3)-C(sp2) Cross-Coupling with Arylboronic Acids.	Amino Acids	117-134	Sp2 transcription factor	Homo sapiens	90-95
32070917-7	2020	Docking studies showed that the novel GluN2B ligands adopt similar binding poses as Ro 25-6981 with the central H-bond interaction between the protonated amino moiety of the ligands and the carbamoyl moiety of Gln110.	Amino Acids	154-159	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	38-44
32040107-1	2020	We present a reaction-based fluorescent probe (1) for Hg2+ and CH3Hg+, based on the displacement reaction of the arylboronic acid with the mercury species.	Amino Acids	113-129	polycystin 1, transient receptor potential channel interacting pseudogene 2	Homo sapiens	54-57
31939666-1	2020	This article describes a novel and practical method for the Cu-catalyzed C(sp3)-C(sp2) cross-coupling of alkylsilyl peroxides with arylboronic acids.	Amino Acids	131-148	Sp2 transcription factor	Homo sapiens	80-85
31952961-0	2020	Potent non-hydroxamate inhibitors of histone deacetylase-8: Role and scope of an isoindolin-2-yl linker with an alpha-amino amide as the zinc-binding unit.	Amino Acids	112-129	histone deacetylase 8	Homo sapiens	37-58
31996378-9	2020	Co-precipitation assays revealed that Fry uses its N-terminal 1-2400 amino-acid-long region to bind to YAP.	Amino Acids	62-79	FRY microtubule binding protein	Homo sapiens	38-41
31996378-9	2020	Co-precipitation assays revealed that Fry uses its N-terminal 1-2400 amino-acid-long region to bind to YAP.	Amino Acids	62-79	Yes1 associated transcriptional regulator	Homo sapiens	103-106
31868610-0	2020	D-amino acid electrochemical biosensor based on D-amino acid oxidase: Mechanism and high performance against enantiomer interference.	Amino Acids	0-12	D-amino acid oxidase	Homo sapiens	48-68
31952961-1	2020	A series of potent inhibitors of histone deacetylase-8 (HDAC8) is described that contains an alpha-amino amide zinc-binding unit and a substituted isoindolinyl capping group.	Amino Acids	93-110	histone deacetylase 8	Homo sapiens	33-54
31952961-1	2020	A series of potent inhibitors of histone deacetylase-8 (HDAC8) is described that contains an alpha-amino amide zinc-binding unit and a substituted isoindolinyl capping group.	Amino Acids	93-110	histone deacetylase 8	Homo sapiens	56-61
31944520-4	2020	The 11-amino acid effector domain of the BASP1 protein interacts with the calcium sensor calmodulin (CaM) and is mainly responsible for this inhibitory function.	Amino Acids	4-17	brain abundant membrane attached signal protein 1	Homo sapiens	41-46
31599087-2	2020	HbA1c is formed by the irreversible modification of N-terminal alpha-amino group of beta globin chain with glucose via Amadori rearrangement.	Amino Acids	63-74	hemoglobin subunit alpha 1	Homo sapiens	0-4
31919866-5	2020	NG001 was synthesized by conjugating the isothiocyanato group of p-SCN-Bn-TCMC to the amino group of a glutamate-urea-based PSMA binding entity.	Amino Acids	86-91	folate hydrolase 1	Homo sapiens	124-128
31786094-18	2020	We have identified novel inhibitors (Tannic acid, Mupirocin, Phytonadiol sodium diphosphate, Cefpiramide, Xenazoic acid) that have potential to decrease the activity of Granzyme B.	Amino Acids	37-48	granzyme B	Homo sapiens	169-179
31972082-5	2020	Here, we synthesized peptide LIQ, an 11-amino acid peptide derived from Drp1-x01 isoform, and reported that LIQ could induce tubulin assembly in vitro.	Amino Acids	37-50	dynamin 1 like	Homo sapiens	72-76
32158763-0	2020	Attenuation of the Hepatoprotective Effects of Ileal Apical Sodium Dependent Bile Acid Transporter (ASBT) Inhibition in Choline-Deficient L-Amino Acid-Defined (CDAA) Diet-Fed Mice.	Amino Acids	138-150	solute carrier family 10, member 2	Mus musculus	100-104
31791875-1	2020	In this work, we fabricate a novel bismuth vanadate/two dimensional-carbon nitride/deoxyribonucleic acid (BiVO4/2D-C3N4/DNA) aptamer photoelectrochemical (PEC) sensor, and this sensor provides a record detection sensitivity area (5 x 10-7 mug/L - 10 mug/L) for Microcystin-LR (MC-LR).	Amino Acids	83-104	immunoglobulin kappa variable 3-7 (non-functional)	Homo sapiens	243-249
32075743-4	2020	Cattle Mxra8 encodes a 15-amino acid insertion in its ectodomain that prevents Mxra8 binding to CHIKV.	Amino Acids	23-36	matrix remodeling associated 8	Bos taurus	7-12
32075743-4	2020	Cattle Mxra8 encodes a 15-amino acid insertion in its ectodomain that prevents Mxra8 binding to CHIKV.	Amino Acids	23-36	matrix remodeling associated 8	Bos taurus	79-84
32052190-4	2020	A glass carbon electrode (GCE) modified with Ag-g-C3N4 can immobilize a large number of amino-terminated thrombin binding aptamers (NH2-TBA) through strong Ag-N bonds.	Amino Acids	88-93	coagulation factor II, thrombin	Homo sapiens	105-113
31740936-4	2020	Reconstruction of the mutation event of our activation-tagged line by creating a line expressing an amino-terminally truncated sequence of NAC052 under control of the GLDTFt promoter, confirmed the involvement of NAC052 in leaf development.	Amino Acids	100-105	NAC domain containing protein 52	Arabidopsis thaliana	139-145
31740936-4	2020	Reconstruction of the mutation event of our activation-tagged line by creating a line expressing an amino-terminally truncated sequence of NAC052 under control of the GLDTFt promoter, confirmed the involvement of NAC052 in leaf development.	Amino Acids	100-105	NAC domain containing protein 52	Arabidopsis thaliana	213-219
31740936-5	2020	Leaf anatomic and transcriptomic effects of an amino-terminally truncated NAC052 under control of the GLDTFt promoter are revealed.	Amino Acids	47-52	NAC domain containing protein 52	Arabidopsis thaliana	74-80
31942597-1	2020	Control of the redox potential of lithium terephthalate Li2TP anode material is demonstrated by functionalizing its terephthalate backbone with an electron-donating amino group; this lowers - as intended - the redox potential of Li2TP by 0.14 V. The two Li-organic electrode materials, Li2TP and Li2TP-NH2, are fabricated as crystalline thin films from gaseous precursors using the atomic/molecular layer deposition (ALD/MLD) technique.	Amino Acids	165-170	ATP binding cassette subfamily A member 12	Homo sapiens	56-59
31677912-5	2020	PDA layer exhibited a high affinity toward Pb(II) by chelating with amino groups.	Amino Acids	68-73	submaxillary gland androgen regulated protein 3B	Homo sapiens	43-49
31897553-4	2020	In order to construct the aptasensor, an amino-modified aptamer was immobilized on CdS-Cu2O NAs/TM to serve as a recognition unit for PSA.	Amino Acids	41-46	kallikrein related peptidase 3	Homo sapiens	134-137
32028649-1	2020	D-amino acid oxidase (DAAO) catalyzes the oxidation of D-amino acids generating hydrogen peroxide, a potential producer of reactive oxygen species.	Amino Acids	55-68	D-amino acid oxidase	Homo sapiens	0-20
32028649-1	2020	D-amino acid oxidase (DAAO) catalyzes the oxidation of D-amino acids generating hydrogen peroxide, a potential producer of reactive oxygen species.	Amino Acids	55-68	D-amino acid oxidase	Homo sapiens	22-26
31740244-4	2020	Meanwhile, GA and TA increased pH, yeasts number, ammonia-N content and aminopeptidase activity.	Amino Acids	18-20	aminopeptidase	Saccharomyces cerevisiae S288C	72-86
31834974-1	2020	The tumor suppressor gene p53 encodes a transcriptional activator that has two transactivation domains (TADs) located in its amino terminus.	Amino Acids	125-130	tumor protein p53	Homo sapiens	26-29
31826399-3	2020	Herein, a novel core-shell adsorbent of poly(vinyl alcohol)/chitosan/amino-grafted silica@polyethylenimine (PVA/CS/SAP@PEI) gel bead was prepared to efficiently uptake DS from wastewater.	Amino Acids	69-74	SH2 domain containing 1A	Homo sapiens	115-122
31721379-1	2020	BACKGROUND: l-amino acids, such as monosodium glutamate (MSG), activate the umami receptor T1R1/T1R3.	Amino Acids	12-25	taste receptor, type 1, member 1	Mus musculus	91-95
31841137-1	2020	A neuropathologic hallmark of Alzheimer"s disease (AD) is the presence of senile plaques that contain neurotoxic amyloid-beta protein (Abeta) species, which are generated by the cleavage of APP by secretases such as the gamma-secretase complex, preferentially located in detergent-resistant membrane (DRM) regions and comprising endoproteolysed amino- and carboxyterminal fragments of presenilin, nicastrin, anterior pharynx defective 1, and presenilin enhancer 2.	Amino Acids	345-350	amyloid beta precursor protein	Homo sapiens	135-140
31782083-5	2020	We also present evidence that eIF4E interacts with the amino terminal domain of S6K1 in a phospho-dependent manner, and this interaction is instrumental in overriding Rapamycin inhibition of S6K1.	Amino Acids	55-60	eukaryotic translation initiation factor 4E	Homo sapiens	30-35
31782083-5	2020	We also present evidence that eIF4E interacts with the amino terminal domain of S6K1 in a phospho-dependent manner, and this interaction is instrumental in overriding Rapamycin inhibition of S6K1.	Amino Acids	55-60	ribosomal protein S6 kinase B1	Homo sapiens	80-84
31789102-0	2020	Tannic acid and vitamin E loaded PLGA nanoparticles ameliorate hepatic injury in a chronic alcoholic liver damage model via EGFR-AKT-STAT3 pathway.	Amino Acids	0-11	signal transducer and activator of transcription 3	Mus musculus	133-138
31721379-1	2020	BACKGROUND: l-amino acids, such as monosodium glutamate (MSG), activate the umami receptor T1R1/T1R3.	Amino Acids	12-25	taste receptor, type 1, member 3	Mus musculus	96-100
31898870-2	2020	Herein, a strategy is proposed for functionalizing CNTs, which can be achieved with any functional group (FG) without degrading their intrinsic structure by using a deoxyribonucleic acid (DNA)-binding peptide (DBP) anchor.	Amino Acids	165-186	D-box binding PAR bZIP transcription factor	Homo sapiens	210-213
31898870-2	2020	Herein, a strategy is proposed for functionalizing CNTs, which can be achieved with any functional group (FG) without degrading their intrinsic structure by using a deoxyribonucleic acid (DNA)-binding peptide (DBP) anchor.	Amino Acids	188-191	D-box binding PAR bZIP transcription factor	Homo sapiens	210-213
31898870-3	2020	By employing a DBP tagged with a certain FG, such as thiol, biotin, and carboxyl acid, it is possible to introduce any FG with a controlled density on DNA-wrapped CNTs.	Amino Acids	151-154	D-box binding PAR bZIP transcription factor	Homo sapiens	15-18
31898870-7	2020	Additionally, the unique DBP-DNA interaction allows the on-demand detachment of the NPs attached to the CNT surface; further, it facilitates a CNT chirality-specific NP attachment and separation using the sequence-specific programmable characteristics of oligonucleotides.	Amino Acids	29-32	D-box binding PAR bZIP transcription factor	Homo sapiens	25-28
31971989-5	2020	In Type II interactions, E6 proteins require additional auxiliary regions of E6AP in either the amino terminus or in the carboxy-terminal HECT domain to interact with the LXXLL peptide motif of E6AP.	Amino Acids	96-101	ubiquitin protein ligase E3A	Homo sapiens	77-81
31704333-4	2020	Furthermore, we investigated the interaction between the vitamin D receptor (VDR) and calcioic acid.	Amino Acids	86-99	vitamin D receptor	Homo sapiens	57-75
31704333-4	2020	Furthermore, we investigated the interaction between the vitamin D receptor (VDR) and calcioic acid.	Amino Acids	86-99	vitamin D receptor	Homo sapiens	77-80
31704333-5	2020	Calcioic acid was able to bind VDR with a binding constant of 71 microM.	Amino Acids	0-13	vitamin D receptor	Homo sapiens	31-34
31704333-6	2020	In cells, calcioic acid reduced the transcription of VDR target gene CYP24A1 in the presence 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) but did not induce the transcription of CYP24A1.	Amino Acids	10-23	vitamin D receptor	Homo sapiens	53-56
31704333-6	2020	In cells, calcioic acid reduced the transcription of VDR target gene CYP24A1 in the presence 1alpha,25-dihydroxyvitamin D3 (1,25(OH)2D3) but did not induce the transcription of CYP24A1.	Amino Acids	10-23	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	69-76
31704333-7	2020	Therefore, calcioic acid is a very weak VDR antagonist.	Amino Acids	11-24	vitamin D receptor	Homo sapiens	40-43
31852729-4	2020	ATF6 resides at the ER, and upon activation is transported to the Golgi apparatus where it is cleaved by proteases to create an amino-terminal cytoplasmic fragment (ATF6f).	Amino Acids	128-133	activating transcription factor 6	Danio rerio	0-4
32021803-2	2020	We report here a family history of severe NAGS deficiency: after the index-case with severe hyperammonemia, one patient benefited from antenatal diagnosis, and from primary care at birth, another one was diagnosed at 2-days and immediately treated with carbaglumic-acid.	Amino Acids	253-269	N-acetylglutamate synthase	Homo sapiens	42-46
31971989-5	2020	In Type II interactions, E6 proteins require additional auxiliary regions of E6AP in either the amino terminus or in the carboxy-terminal HECT domain to interact with the LXXLL peptide motif of E6AP.	Amino Acids	96-101	ubiquitin protein ligase E3A	Homo sapiens	194-198
31971989-6	2020	A region of E6AP amino-terminal to the LXXLL peptide motif both augments association with E6 proteins and is required for E6 proteins to trigger ubiquitin ligase activity in the carboxy-terminal HECT ubiquitin ligase domain of E6AP.	Amino Acids	17-22	ubiquitin protein ligase E3A	Homo sapiens	12-16
31971989-6	2020	A region of E6AP amino-terminal to the LXXLL peptide motif both augments association with E6 proteins and is required for E6 proteins to trigger ubiquitin ligase activity in the carboxy-terminal HECT ubiquitin ligase domain of E6AP.	Amino Acids	17-22	ubiquitin protein ligase E3A	Homo sapiens	227-231
31971989-9	2020	This classification of E6-E6AP interaction types and identification of a region in the E6AP amino terminus that is important for both E6 association and stimulation of ubiquitin ligase activity will inform future structural data of the E6-E6AP complex and future studies aiming to interfere with the activity of the E6-E6AP complex.	Amino Acids	92-97	ubiquitin protein ligase E3A	Homo sapiens	26-30
31860256-6	2020	Most importantly, the MOF transitions from its narrow-pore form to its large-pore form during this treatment, which allows the PI chains to partly penetrate the pores and cross-link with the amino functions at the pore mouth of the NH2-MIL-53(Al) and stabilizes the open-pore form of NH2-MIL-53(Al).	Amino Acids	191-196	lysine acetyltransferase 8	Homo sapiens	22-25
31854983-5	2020	PLP can form a Schiff base (an aldimine) with the primary amino group of Cys/NAC-AuNC through its aldehyde group and thereby suppresses the fluorescence of Cys/NAC-AuNC.	Amino Acids	58-63	X-linked Kx blood group	Homo sapiens	77-80
31854983-5	2020	PLP can form a Schiff base (an aldimine) with the primary amino group of Cys/NAC-AuNC through its aldehyde group and thereby suppresses the fluorescence of Cys/NAC-AuNC.	Amino Acids	58-63	X-linked Kx blood group	Homo sapiens	160-163
31812751-5	2020	Meanwhile, covalent linkage formed between the amino group of O-CMCS and the carboxyl group of GA via amide bond.	Amino Acids	47-52	cerebral malaria susceptibility in CBA/N	Mus musculus	64-68
31790661-9	2020	Our results revealed that ursonic acid inhibited transcriptional expression of gelatinases (MMP-2 and MMP-9) via inhibition of ERK and CREB signaling pathways in NSCLC cells.	Amino Acids	26-38	mitogen-activated protein kinase 1	Homo sapiens	127-130
31740453-8	2020	The END-1,3 proteins share a region upstream of their zinc finger and an unusual amino-terminal poly-serine domain exhibiting high codon bias.	Amino Acids	81-86	GATA-type domain-containing protein	Caenorhabditis elegans	4-9
31915765-1	2020	Copper mediated C(sp2)-H amination and hydroxylation of arylphosphinic acid are accomplished by adopting phosphinamide as the directing group.	Amino Acids	56-75	Sp2 transcription factor	Homo sapiens	16-21
31790661-9	2020	Our results revealed that ursonic acid inhibited transcriptional expression of gelatinases (MMP-2 and MMP-9) via inhibition of ERK and CREB signaling pathways in NSCLC cells.	Amino Acids	26-38	cAMP responsive element binding protein 1	Homo sapiens	135-139
31790661-10	2020	Moreover, ursonic acid reduced mRNA levels of collagenase (MMP-1) via suppression of ERK and c-Fos signaling pathways in HaCaT keratinocytes.	Amino Acids	10-22	matrix metallopeptidase 1	Homo sapiens	59-64
31790661-10	2020	Moreover, ursonic acid reduced mRNA levels of collagenase (MMP-1) via suppression of ERK and c-Fos signaling pathways in HaCaT keratinocytes.	Amino Acids	10-22	mitogen-activated protein kinase 1	Homo sapiens	85-88
31790661-10	2020	Moreover, ursonic acid reduced mRNA levels of collagenase (MMP-1) via suppression of ERK and c-Fos signaling pathways in HaCaT keratinocytes.	Amino Acids	10-22	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	93-98
31686429-0	2020	Synthesis and penicillin-binding protein inhibitory assessment of dipeptidic 4-phenyl-beta-lactams from alpha-amino acid-derived imines.	Amino Acids	104-120	phosphatidylethanolamine binding protein 1	Homo sapiens	14-40
31669698-4	2020	We developed four synthetic approaches to generate RBC-Staphylococcal protein A (RBC-SpA) complexes: amino group targeting through N-hydrosuccinidyl ester-functionalized homobifunctional poly(ethylene glycol) (NHS-PEG-NHS), direct thiol group targeting using heterobifunctional NHS-PEG-maleimide (NHS-PEG-MAL), converted thiol targeting using heterobifunctional NHS-PEG-MAL, and click chemistry using a heterobifunctional NHS-PEG-azido (NHS-PEG-N3) and NHS-PEG-alkyne (NHS-PEG-alk).	Amino Acids	101-106	surfactant protein A1	Homo sapiens	85-88
31548229-1	2020	Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) encodes a 403-amino acid protein with an amino-terminal domain that shares sequence homology with the actin-binding protein tensin and the putative tyrosine-protein phosphatase auxilin.	Amino Acids	77-82	phosphatase and tensin homolog	Homo sapiens	57-61
31791680-3	2020	It was shown by molecular docking calculations and in vitro experiments that amino and betaine derivatives can inhibit acetylcholinesterase and butyrylcholinesterase on the level of pyridostigmine while the toxicity of the obtained compounds is much lower than that of pyridostigmine.	Amino Acids	77-82	butyrylcholinesterase	Homo sapiens	144-165
31735601-2	2020	Initial biological studies indicated that among these 4-amino acid derivative substituted pyrimidine nucleoside analogues, 4-N-(2"-amino-glutaric acid-1"-methylester)-1-(2"- deoxy-2"-beta-fluoro-4"-azido)-furanosyl-cytosine 2 exhibited the most potent anti-CVB activity (IC50 = 9.3 muM).	Amino Acids	54-66	latexin	Homo sapiens	282-285
31884142-8	2020	The presence of the amino protonated group attached at the benzothiazole moiety was essential for the antiproliferative and antioxidant activity observed, exerted through a change in the levels of the reactive oxygen species-modulated HIF-1 protein.	Amino Acids	20-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	235-240
31793427-3	2020	Due to its ability to effect phosphorylation of numerous client proteins, inhibition of Hsp90 has been an attractive anticancer approach since the early 1990"s, when researchers identified a druggable target on the amino terminus of Hsp90 for a variety of cancers.	Amino Acids	215-220	heat shock protein 90 alpha family class A member 1	Homo sapiens	88-93
31911297-1	2020	New series of pyrazole derivatives Va-c, VIa-c, VIIa-f, and VIII possessing amino/methanesulphonyl moiety as COX-2 pharmacophore were designed and synthesized.	Amino Acids	76-81	cytochrome c oxidase subunit 8A	Homo sapiens	60-64
31911297-1	2020	New series of pyrazole derivatives Va-c, VIa-c, VIIa-f, and VIII possessing amino/methanesulphonyl moiety as COX-2 pharmacophore were designed and synthesized.	Amino Acids	76-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
31689524-10	2020	CONCLUSIONS: Variation in the prescription of anti-osteoporosis drugs exists across GPs and CCGs in England, this being more prominent for certain drugs (e.g. denosumab) compared with others (e.g. alendronic acid).	Amino Acids	197-212	TATA-box binding protein associated factor 1	Homo sapiens	92-96
31790661-0	2020	Ursonic acid exerts inhibitory effects on matrix metalloproteinases via ERK signaling pathway.	Amino Acids	0-12	mitogen-activated protein kinase 1	Homo sapiens	72-75
31790661-4	2020	In this study, we investigated the possibility of ursonic acid as an anti-cancer/anti-skin aging agent targeting MMPs.	Amino Acids	50-62	matrix metallopeptidase 1	Homo sapiens	113-117
31790661-7	2020	Effects of ursonic acid on MMPs were analyzed by zymography assays and quantitative real time polymerase chain reaction (qRT-PCR).	Amino Acids	11-23	matrix metallopeptidase 1	Homo sapiens	27-31
31790661-8	2020	We also conducted flow cytometry and western blot analysis to elucidate the mechanisms of MMP regulation by ursonic acid.	Amino Acids	108-120	matrix metallopeptidase 1	Homo sapiens	90-93
31790661-9	2020	Our results revealed that ursonic acid inhibited transcriptional expression of gelatinases (MMP-2 and MMP-9) via inhibition of ERK and CREB signaling pathways in NSCLC cells.	Amino Acids	26-38	matrix metallopeptidase 2	Homo sapiens	92-97
31793427-3	2020	Due to its ability to effect phosphorylation of numerous client proteins, inhibition of Hsp90 has been an attractive anticancer approach since the early 1990"s, when researchers identified a druggable target on the amino terminus of Hsp90 for a variety of cancers.	Amino Acids	215-220	heat shock protein 90 alpha family class A member 1	Homo sapiens	233-238
31790661-9	2020	Our results revealed that ursonic acid inhibited transcriptional expression of gelatinases (MMP-2 and MMP-9) via inhibition of ERK and CREB signaling pathways in NSCLC cells.	Amino Acids	26-38	matrix metallopeptidase 9	Homo sapiens	102-107
31889499-2	2020	BACKGROUND: It was found that breast cancer susceptibility protein1 (BRCA1) binds to estrogen receptor alpha (ERalpha) and inhibits its activity by direct interaction between domains within the amino terminus of BRCA1 and the carboxy terminus of ER alpha.	Amino Acids	194-199	BRCA1 DNA repair associated	Homo sapiens	30-67
31889499-2	2020	BACKGROUND: It was found that breast cancer susceptibility protein1 (BRCA1) binds to estrogen receptor alpha (ERalpha) and inhibits its activity by direct interaction between domains within the amino terminus of BRCA1 and the carboxy terminus of ER alpha.	Amino Acids	194-199	BRCA1 DNA repair associated	Homo sapiens	69-74
31889499-2	2020	BACKGROUND: It was found that breast cancer susceptibility protein1 (BRCA1) binds to estrogen receptor alpha (ERalpha) and inhibits its activity by direct interaction between domains within the amino terminus of BRCA1 and the carboxy terminus of ER alpha.	Amino Acids	194-199	estrogen receptor 1	Homo sapiens	85-108
31889499-2	2020	BACKGROUND: It was found that breast cancer susceptibility protein1 (BRCA1) binds to estrogen receptor alpha (ERalpha) and inhibits its activity by direct interaction between domains within the amino terminus of BRCA1 and the carboxy terminus of ER alpha.	Amino Acids	194-199	estrogen receptor 1	Homo sapiens	110-117
31585115-2	2020	Molecular cloning indicated that the deduced amino acid sequences of the pheasant motilin and ghrelin were a 22-amino acid peptide, FVPFFTQSDIQKMQEKERIKGQ, and a 26-amino acid peptide, GSSFLSPAYKNIQQQKDTRKPTGRLH, respectively.	Amino Acids	109-122	motilin	Gallus gallus	82-89
31660823-5	2020	Earlier, Inhibition of D-amino acid oxidase (DAAO) that may metabolize D-amino acids and thereby activate NMDAR has been reported to be beneficial for patients with schizophrenia receiving antipsychotics except clozapine.	Amino Acids	71-84	D-amino acid oxidase	Homo sapiens	23-43
31660823-5	2020	Earlier, Inhibition of D-amino acid oxidase (DAAO) that may metabolize D-amino acids and thereby activate NMDAR has been reported to be beneficial for patients with schizophrenia receiving antipsychotics except clozapine.	Amino Acids	71-84	D-amino acid oxidase	Homo sapiens	45-49
31585115-2	2020	Molecular cloning indicated that the deduced amino acid sequences of the pheasant motilin and ghrelin were a 22-amino acid peptide, FVPFFTQSDIQKMQEKERIKGQ, and a 26-amino acid peptide, GSSFLSPAYKNIQQQKDTRKPTGRLH, respectively.	Amino Acids	109-122	ghrelin/obestatin prepropeptide	Gallus gallus	94-101
31585115-2	2020	Molecular cloning indicated that the deduced amino acid sequences of the pheasant motilin and ghrelin were a 22-amino acid peptide, FVPFFTQSDIQKMQEKERIKGQ, and a 26-amino acid peptide, GSSFLSPAYKNIQQQKDTRKPTGRLH, respectively.	Amino Acids	162-175	motilin	Gallus gallus	82-89
31585115-2	2020	Molecular cloning indicated that the deduced amino acid sequences of the pheasant motilin and ghrelin were a 22-amino acid peptide, FVPFFTQSDIQKMQEKERIKGQ, and a 26-amino acid peptide, GSSFLSPAYKNIQQQKDTRKPTGRLH, respectively.	Amino Acids	162-175	ghrelin/obestatin prepropeptide	Gallus gallus	94-101
31880252-0	2020	Design, synthesis and biological evaluation of 4-amino substituted 2H-chromen-2-one derivatives as an NEDD8 activating enzyme inhibitor in pancreatic cancer cells.	Amino Acids	47-54	NEDD8 ubiquitin like modifier	Homo sapiens	102-107
32408253-2	2020	We aimed to evaluate the effect of amino acids (AAs) on expression of IGF1 and IGF1-dependent genes in human myotubes and skeletal muscle and supposed that AAs administration increases IGF1 levels in blood and expression of IGF1 and IGF1-dependent genes in trained skeletal muscle, thereby reducing training-induced muscle damage.	Amino Acids	48-51	insulin like growth factor 1	Homo sapiens	70-74
32408253-2	2020	We aimed to evaluate the effect of amino acids (AAs) on expression of IGF1 and IGF1-dependent genes in human myotubes and skeletal muscle and supposed that AAs administration increases IGF1 levels in blood and expression of IGF1 and IGF1-dependent genes in trained skeletal muscle, thereby reducing training-induced muscle damage.	Amino Acids	48-51	insulin like growth factor 1	Homo sapiens	79-83
32408253-2	2020	We aimed to evaluate the effect of amino acids (AAs) on expression of IGF1 and IGF1-dependent genes in human myotubes and skeletal muscle and supposed that AAs administration increases IGF1 levels in blood and expression of IGF1 and IGF1-dependent genes in trained skeletal muscle, thereby reducing training-induced muscle damage.	Amino Acids	48-51	insulin like growth factor 1	Homo sapiens	79-83
32408253-2	2020	We aimed to evaluate the effect of amino acids (AAs) on expression of IGF1 and IGF1-dependent genes in human myotubes and skeletal muscle and supposed that AAs administration increases IGF1 levels in blood and expression of IGF1 and IGF1-dependent genes in trained skeletal muscle, thereby reducing training-induced muscle damage.	Amino Acids	48-51	insulin like growth factor 1	Homo sapiens	79-83
32408253-2	2020	We aimed to evaluate the effect of amino acids (AAs) on expression of IGF1 and IGF1-dependent genes in human myotubes and skeletal muscle and supposed that AAs administration increases IGF1 levels in blood and expression of IGF1 and IGF1-dependent genes in trained skeletal muscle, thereby reducing training-induced muscle damage.	Amino Acids	48-51	insulin like growth factor 1	Homo sapiens	79-83
32408253-2	2020	We aimed to evaluate the effect of amino acids (AAs) on expression of IGF1 and IGF1-dependent genes in human myotubes and skeletal muscle and supposed that AAs administration increases IGF1 levels in blood and expression of IGF1 and IGF1-dependent genes in trained skeletal muscle, thereby reducing training-induced muscle damage.	Amino Acids	156-159	insulin like growth factor 1	Homo sapiens	70-74
32408253-2	2020	We aimed to evaluate the effect of amino acids (AAs) on expression of IGF1 and IGF1-dependent genes in human myotubes and skeletal muscle and supposed that AAs administration increases IGF1 levels in blood and expression of IGF1 and IGF1-dependent genes in trained skeletal muscle, thereby reducing training-induced muscle damage.	Amino Acids	156-159	insulin like growth factor 1	Homo sapiens	79-83
32408253-2	2020	We aimed to evaluate the effect of amino acids (AAs) on expression of IGF1 and IGF1-dependent genes in human myotubes and skeletal muscle and supposed that AAs administration increases IGF1 levels in blood and expression of IGF1 and IGF1-dependent genes in trained skeletal muscle, thereby reducing training-induced muscle damage.	Amino Acids	156-159	insulin like growth factor 1	Homo sapiens	79-83
32408253-2	2020	We aimed to evaluate the effect of amino acids (AAs) on expression of IGF1 and IGF1-dependent genes in human myotubes and skeletal muscle and supposed that AAs administration increases IGF1 levels in blood and expression of IGF1 and IGF1-dependent genes in trained skeletal muscle, thereby reducing training-induced muscle damage.	Amino Acids	156-159	insulin like growth factor 1	Homo sapiens	79-83
32408253-2	2020	We aimed to evaluate the effect of amino acids (AAs) on expression of IGF1 and IGF1-dependent genes in human myotubes and skeletal muscle and supposed that AAs administration increases IGF1 levels in blood and expression of IGF1 and IGF1-dependent genes in trained skeletal muscle, thereby reducing training-induced muscle damage.	Amino Acids	156-159	insulin like growth factor 1	Homo sapiens	79-83
32408253-8	2020	CONCLUSIONS: AAs administration increases IGF1 expression in vitro and in vivo.	Amino Acids	13-16	insulin like growth factor 1	Homo sapiens	42-46
32408253-9	2020	To obtain more pronounced changes in expression of IGF1 and IGF1-dependent genes in skeletal muscle, it may be necessary to increase the dose and/or duration of AAs administration.	Amino Acids	161-164	insulin like growth factor 1	Homo sapiens	51-55
32408253-9	2020	To obtain more pronounced changes in expression of IGF1 and IGF1-dependent genes in skeletal muscle, it may be necessary to increase the dose and/or duration of AAs administration.	Amino Acids	161-164	insulin like growth factor 1	Homo sapiens	60-64
31977880-2	2020	The aim of this study was to investigate the association between the deoxyribonucleic acid (DNA) methylation of HTR4 promoter and autism spectrum disorder (ASD), a disease characterized by communication disorder and repetitive or restrictive behavior.Peripheral blood DNA was obtained from 61 ASD children and 66 healthy children, and the DNA methylation of HTR4 promoter was assessed by quantitative methylation-specific polymerase chain reaction.	Amino Acids	69-90	5-hydroxytryptamine receptor 4	Homo sapiens	112-116
31977880-2	2020	The aim of this study was to investigate the association between the deoxyribonucleic acid (DNA) methylation of HTR4 promoter and autism spectrum disorder (ASD), a disease characterized by communication disorder and repetitive or restrictive behavior.Peripheral blood DNA was obtained from 61 ASD children and 66 healthy children, and the DNA methylation of HTR4 promoter was assessed by quantitative methylation-specific polymerase chain reaction.	Amino Acids	92-95	5-hydroxytryptamine receptor 4	Homo sapiens	112-116
31977880-2	2020	The aim of this study was to investigate the association between the deoxyribonucleic acid (DNA) methylation of HTR4 promoter and autism spectrum disorder (ASD), a disease characterized by communication disorder and repetitive or restrictive behavior.Peripheral blood DNA was obtained from 61 ASD children and 66 healthy children, and the DNA methylation of HTR4 promoter was assessed by quantitative methylation-specific polymerase chain reaction.	Amino Acids	92-95	5-hydroxytryptamine receptor 4	Homo sapiens	358-362
31977880-2	2020	The aim of this study was to investigate the association between the deoxyribonucleic acid (DNA) methylation of HTR4 promoter and autism spectrum disorder (ASD), a disease characterized by communication disorder and repetitive or restrictive behavior.Peripheral blood DNA was obtained from 61 ASD children and 66 healthy children, and the DNA methylation of HTR4 promoter was assessed by quantitative methylation-specific polymerase chain reaction.	Amino Acids	268-271	5-hydroxytryptamine receptor 4	Homo sapiens	112-116
31977880-2	2020	The aim of this study was to investigate the association between the deoxyribonucleic acid (DNA) methylation of HTR4 promoter and autism spectrum disorder (ASD), a disease characterized by communication disorder and repetitive or restrictive behavior.Peripheral blood DNA was obtained from 61 ASD children and 66 healthy children, and the DNA methylation of HTR4 promoter was assessed by quantitative methylation-specific polymerase chain reaction.	Amino Acids	268-271	5-hydroxytryptamine receptor 4	Homo sapiens	112-116
31977880-4	2020	Our results showed that the DNA methylation levels of HTR4 promoter were significantly lower in children with ASD than in healthy children (median PMR: 66.23% vs 94.31%,P = .028, age-adjusted P = .034).	Amino Acids	28-31	5-hydroxytryptamine receptor 4	Homo sapiens	54-58
31977880-5	2020	In addition, the DNA methylation of HTR4 promoter was inversely associated with age in male ASD cases (total cases: r = -0.283, P = .027; male cases: r = -0.431, P = .002; female cases: r = -0.108, P = .752).	Amino Acids	17-20	5-hydroxytryptamine receptor 4	Homo sapiens	36-40
31792442-5	2020	HSP70 recognizes the amino (N)-terminal flexible region, as well as the glutathione S-transferase domain of AIMP2-DX2, via its substrate-binding domain, thus blocking the Siah1-dependent ubiquitination of AIMP2-DX2.	Amino Acids	21-26	heat shock protein family A (Hsp70) member 4	Homo sapiens	0-5
31915328-0	2020	Serum Amino-Terminal Pro-B Type Natriuretic Peptide (NT-pro BNP) Status among Heart Failure (HF) Patients in Bangladesh.	Amino Acids	6-11	natriuretic peptide B	Homo sapiens	60-63
31889499-2	2020	BACKGROUND: It was found that breast cancer susceptibility protein1 (BRCA1) binds to estrogen receptor alpha (ERalpha) and inhibits its activity by direct interaction between domains within the amino terminus of BRCA1 and the carboxy terminus of ER alpha.	Amino Acids	194-199	BRCA1 DNA repair associated	Homo sapiens	212-217
31889499-2	2020	BACKGROUND: It was found that breast cancer susceptibility protein1 (BRCA1) binds to estrogen receptor alpha (ERalpha) and inhibits its activity by direct interaction between domains within the amino terminus of BRCA1 and the carboxy terminus of ER alpha.	Amino Acids	194-199	estrogen receptor 1	Homo sapiens	246-254
31539818-2	2020	During cardiac surgery, the administration of high-dose insulin along with dextrose titration maintains normoglycemia, but dramatically decreases plasma amino acids (AAs) compared with preoperative fasting levels.	Amino Acids	166-169	insulin	Homo sapiens	56-63
31539818-4	2020	We investigated whether parenteral infusion of AAs during and immediately after cardiac surgery would prevent hypoaminoacidemia in patients who receive high-dose insulin therapy.	Amino Acids	47-50	insulin	Homo sapiens	162-169
31956844-1	2020	Herein, we disclose Ru(II)-catalyzed regioselective distal C(sp2)-H arylation of quinoline N-oxide with arylboronic acids to 8-arylquinolines.	Amino Acids	104-121	Sp2 transcription factor	Homo sapiens	59-64
31938070-2	2020	Methods: Here, we truncated 14-amino-acids at the N-terminus of MSI-78 to obtain MSI and further modified MSI to obtain four peptide analogs: MSI-1, MSI-2, MSI-3 and MSI-4.	Amino Acids	28-42	phenylalkylamine Ca2+ antagonist (emopamil) binding protein	Mus musculus	64-67
31905967-6	2019	We found that LPS-induced expression of pro-form MMP-9 and cell migration were mediated through TLR4, proto-oncogene tyrosine-protein kinase (c-Src), proline-rich tyrosine kinase 2 (Pyk2), platelet-derived growth factor receptor (PDGFR), phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), p38 mitogen-activated protein kinase (MAPK), and Jun amino-terminal kinase (JNK)1/2 signaling molecules in RBA-1 cells.	Amino Acids	348-353	matrix metallopeptidase 9	Rattus norvegicus	49-54
31748410-3	2019	Trio whole exome sequencing revealed a de novo missense variant in TNNC1 that encodes a p.Ile4Met substitution in the amino-terminal helix of cardiac troponin C (cTnC).	Amino Acids	118-123	troponin C1, slow skeletal and cardiac type	Homo sapiens	67-72
31748410-3	2019	Trio whole exome sequencing revealed a de novo missense variant in TNNC1 that encodes a p.Ile4Met substitution in the amino-terminal helix of cardiac troponin C (cTnC).	Amino Acids	118-123	troponin C1, slow skeletal and cardiac type	Homo sapiens	142-160
31748410-3	2019	Trio whole exome sequencing revealed a de novo missense variant in TNNC1 that encodes a p.Ile4Met substitution in the amino-terminal helix of cardiac troponin C (cTnC).	Amino Acids	118-123	troponin C1, slow skeletal and cardiac type	Homo sapiens	162-166
31877915-3	2019	WAP was mainly composed of glucose, galactose, arabinose and glacturonic acid, with glucan, arabinogalactan and RG-I regions, and it showed loosely irregular sheet conformation.	Amino Acids	61-77	whey acidic protein	Rattus norvegicus	0-3
33479614-1	2020	Different natural aromatic/heterocyclic l-amino acids were biotransformed into aryl/heteroaryl ethanol metabolites via oxidative deamination, decarboxylation and reduction cascades using live baker"s yeast cells producing intracellular human CYP2D6 enzyme.	Amino Acids	40-53	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	242-248
31877739-5	2019	The P6 peptide is a 20-amino acid residue peptide that binds to CD44.	Amino Acids	20-33	CD44 molecule (Indian blood group)	Homo sapiens	64-68
31729529-0	2019	Cajanonic acid A regulates the ratio of Th17/Treg via inhibition of expression of IL-6 and TGF-beta in insulin-resistant HepG2 cells.	Amino Acids	0-16	interleukin 6	Homo sapiens	82-86
31729529-0	2019	Cajanonic acid A regulates the ratio of Th17/Treg via inhibition of expression of IL-6 and TGF-beta in insulin-resistant HepG2 cells.	Amino Acids	0-16	transforming growth factor beta 1	Homo sapiens	91-99
31729529-0	2019	Cajanonic acid A regulates the ratio of Th17/Treg via inhibition of expression of IL-6 and TGF-beta in insulin-resistant HepG2 cells.	Amino Acids	0-16	insulin	Homo sapiens	103-110
31729529-1	2019	BACKGROUND: The objectives of this study are to investigate whether cajanonic acid A (CAA) can reduce insulin resistance in HepG2 cells and to gain a preliminary understanding of the mechanisms underlying this effect.	Amino Acids	68-84	teashirt zinc finger homeobox 1	Homo sapiens	86-89
31729529-1	2019	BACKGROUND: The objectives of this study are to investigate whether cajanonic acid A (CAA) can reduce insulin resistance in HepG2 cells and to gain a preliminary understanding of the mechanisms underlying this effect.	Amino Acids	68-84	insulin	Homo sapiens	102-109
31820646-3	2019	Enantioselective synthesis of three spin-labeled l-amino acids is described, starting from readily available 2,2,6,6-tetramethyl-4-piperidinone.	Amino Acids	49-62	spindlin 1	Homo sapiens	36-40
31835567-0	2019	Adhesive, Transparent Tannic Acid@ Sulfonated Lignin-PAM Ionic Conductive Hydrogel Electrode with Anti-UV, Antibacterial and Mild Antioxidant Function.	Amino Acids	22-33	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	53-56
31909181-3	2020	In this study, an 18-amino-acids antimicrobial peptide, AcrAP1 (named AP1-Z1), was used as a template.	Amino Acids	18-32	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	59-62
31550389-2	2019	We report two different routes for the synthesis of thiocyameluric acid and its reaction to tris(aryldithio)- and tris(alkyldithio)cyamelurates C6N7(SSR)3 as well as transformation to alkali metal thiocyamelurates M3[C6N7S3], M = Na, K. These compounds were characterised by FTIR-, Raman-, solution 13C- and 1H-NMR-spectroscopy, thermal gravimetric analysis (TGA) and elemental analysis.	Amino Acids	52-71	signal sequence receptor subunit 3	Homo sapiens	144-154
31410629-0	2019	Expression patterns of L-amino acid receptors in the murine STC-1 enteroendocrine cell line.	Amino Acids	23-35	stanniocalcin 1	Mus musculus	60-65
31410629-2	2019	Luminal L-amino acids (L-AA) are detected by several receptors including metabotropic glutamate receptors 1 and 4 (mGluR1 and mGluR4), calcium-sensing receptor (CaSR), GPRC family C group 6 subtype A receptor (GPRC6A) and umami taste receptor heterodimer T1R1/T1R3.	Amino Acids	8-21	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	86-113
31410629-2	2019	Luminal L-amino acids (L-AA) are detected by several receptors including metabotropic glutamate receptors 1 and 4 (mGluR1 and mGluR4), calcium-sensing receptor (CaSR), GPRC family C group 6 subtype A receptor (GPRC6A) and umami taste receptor heterodimer T1R1/T1R3.	Amino Acids	8-21	glutamate receptor, metabotropic 1	Mus musculus	115-121
31410629-2	2019	Luminal L-amino acids (L-AA) are detected by several receptors including metabotropic glutamate receptors 1 and 4 (mGluR1 and mGluR4), calcium-sensing receptor (CaSR), GPRC family C group 6 subtype A receptor (GPRC6A) and umami taste receptor heterodimer T1R1/T1R3.	Amino Acids	8-21	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	126-132
31410629-2	2019	Luminal L-amino acids (L-AA) are detected by several receptors including metabotropic glutamate receptors 1 and 4 (mGluR1 and mGluR4), calcium-sensing receptor (CaSR), GPRC family C group 6 subtype A receptor (GPRC6A) and umami taste receptor heterodimer T1R1/T1R3.	Amino Acids	8-21	calcium-sensing receptor	Mus musculus	135-159
31410629-2	2019	Luminal L-amino acids (L-AA) are detected by several receptors including metabotropic glutamate receptors 1 and 4 (mGluR1 and mGluR4), calcium-sensing receptor (CaSR), GPRC family C group 6 subtype A receptor (GPRC6A) and umami taste receptor heterodimer T1R1/T1R3.	Amino Acids	8-21	calcium-sensing receptor	Mus musculus	161-165
31410629-2	2019	Luminal L-amino acids (L-AA) are detected by several receptors including metabotropic glutamate receptors 1 and 4 (mGluR1 and mGluR4), calcium-sensing receptor (CaSR), GPRC family C group 6 subtype A receptor (GPRC6A) and umami taste receptor heterodimer T1R1/T1R3.	Amino Acids	8-21	G protein-coupled receptor, family C, group 6, member A	Mus musculus	168-208
31410629-2	2019	Luminal L-amino acids (L-AA) are detected by several receptors including metabotropic glutamate receptors 1 and 4 (mGluR1 and mGluR4), calcium-sensing receptor (CaSR), GPRC family C group 6 subtype A receptor (GPRC6A) and umami taste receptor heterodimer T1R1/T1R3.	Amino Acids	8-21	G protein-coupled receptor, family C, group 6, member A	Mus musculus	210-216
31410629-2	2019	Luminal L-amino acids (L-AA) are detected by several receptors including metabotropic glutamate receptors 1 and 4 (mGluR1 and mGluR4), calcium-sensing receptor (CaSR), GPRC family C group 6 subtype A receptor (GPRC6A) and umami taste receptor heterodimer T1R1/T1R3.	Amino Acids	8-21	taste receptor, type 1, member 1	Mus musculus	255-259
31410629-2	2019	Luminal L-amino acids (L-AA) are detected by several receptors including metabotropic glutamate receptors 1 and 4 (mGluR1 and mGluR4), calcium-sensing receptor (CaSR), GPRC family C group 6 subtype A receptor (GPRC6A) and umami taste receptor heterodimer T1R1/T1R3.	Amino Acids	8-21	taste receptor, type 1, member 3	Mus musculus	260-264
32042322-7	2020	Meanwhile, a 21-amino acid peptide encoded by upstream open reading frame of MZF1, termed as MZF1-uPEP, bound to zinc finger domain of Yin Yang 1 (YY1), resulting in repressed transactivation of YY1 and decreased transcription of MZF1 and downstream genes HK2 and PGK1.	Amino Acids	13-26	myeloid zinc finger 1	Mus musculus	77-81
32042322-7	2020	Meanwhile, a 21-amino acid peptide encoded by upstream open reading frame of MZF1, termed as MZF1-uPEP, bound to zinc finger domain of Yin Yang 1 (YY1), resulting in repressed transactivation of YY1 and decreased transcription of MZF1 and downstream genes HK2 and PGK1.	Amino Acids	13-26	myeloid zinc finger 1	Mus musculus	93-97
32042322-7	2020	Meanwhile, a 21-amino acid peptide encoded by upstream open reading frame of MZF1, termed as MZF1-uPEP, bound to zinc finger domain of Yin Yang 1 (YY1), resulting in repressed transactivation of YY1 and decreased transcription of MZF1 and downstream genes HK2 and PGK1.	Amino Acids	13-26	YY1 transcription factor	Homo sapiens	135-145
32042322-7	2020	Meanwhile, a 21-amino acid peptide encoded by upstream open reading frame of MZF1, termed as MZF1-uPEP, bound to zinc finger domain of Yin Yang 1 (YY1), resulting in repressed transactivation of YY1 and decreased transcription of MZF1 and downstream genes HK2 and PGK1.	Amino Acids	13-26	YY1 transcription factor	Mus musculus	147-150
32042322-7	2020	Meanwhile, a 21-amino acid peptide encoded by upstream open reading frame of MZF1, termed as MZF1-uPEP, bound to zinc finger domain of Yin Yang 1 (YY1), resulting in repressed transactivation of YY1 and decreased transcription of MZF1 and downstream genes HK2 and PGK1.	Amino Acids	13-26	YY1 transcription factor	Mus musculus	195-198
32042322-7	2020	Meanwhile, a 21-amino acid peptide encoded by upstream open reading frame of MZF1, termed as MZF1-uPEP, bound to zinc finger domain of Yin Yang 1 (YY1), resulting in repressed transactivation of YY1 and decreased transcription of MZF1 and downstream genes HK2 and PGK1.	Amino Acids	13-26	myeloid zinc finger 1	Mus musculus	93-97
32042322-7	2020	Meanwhile, a 21-amino acid peptide encoded by upstream open reading frame of MZF1, termed as MZF1-uPEP, bound to zinc finger domain of Yin Yang 1 (YY1), resulting in repressed transactivation of YY1 and decreased transcription of MZF1 and downstream genes HK2 and PGK1.	Amino Acids	13-26	hexokinase 2	Mus musculus	256-259
32042322-7	2020	Meanwhile, a 21-amino acid peptide encoded by upstream open reading frame of MZF1, termed as MZF1-uPEP, bound to zinc finger domain of Yin Yang 1 (YY1), resulting in repressed transactivation of YY1 and decreased transcription of MZF1 and downstream genes HK2 and PGK1.	Amino Acids	13-26	phosphoglycerate kinase 1	Mus musculus	264-268
31905967-6	2019	We found that LPS-induced expression of pro-form MMP-9 and cell migration were mediated through TLR4, proto-oncogene tyrosine-protein kinase (c-Src), proline-rich tyrosine kinase 2 (Pyk2), platelet-derived growth factor receptor (PDGFR), phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), p38 mitogen-activated protein kinase (MAPK), and Jun amino-terminal kinase (JNK)1/2 signaling molecules in RBA-1 cells.	Amino Acids	348-353	protein tyrosine kinase 2 beta	Rattus norvegicus	182-186
31766621-6	2019	Expression of mitogen-activated protein kinases (MAPKs) of phosphorylated (p)-c-Jun amino-terminal kinase, p-extracellular signal regulated kinase, and p-p38 in BMDMs were increased by GOS, as well as the p-Stat1.	Amino Acids	84-89	jun proto-oncogene	Mus musculus	78-83
31766621-6	2019	Expression of mitogen-activated protein kinases (MAPKs) of phosphorylated (p)-c-Jun amino-terminal kinase, p-extracellular signal regulated kinase, and p-p38 in BMDMs were increased by GOS, as well as the p-Stat1.	Amino Acids	84-89	signal transducer and activator of transcription 1	Mus musculus	207-212
31591270-8	2019	A peptide comprising residues 2-17 of ARF1 ([2-17]ARF1) inhibited GAP activity and PIP2-dependently bound to a protein containing the PH domain and a 17-amino-acid-long interdomain linker immediately N-terminal to the first beta-strand of the PH domain.	Amino Acids	150-163	ADP ribosylation factor 1	Homo sapiens	38-42
31766500-2	2019	The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into highly reactive aldehydes, which spontaneously react with surrounding amino groups and other aldehydes to form inter- and intra-catenary covalent cross-linkages.	Amino Acids	186-191	lysyl oxidase	Homo sapiens	20-23
31766500-2	2019	The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into highly reactive aldehydes, which spontaneously react with surrounding amino groups and other aldehydes to form inter- and intra-catenary covalent cross-linkages.	Amino Acids	186-191	elastin	Homo sapiens	96-103
31749073-0	2019	Electrochemiluminescent immunoassay for neuron specific enolase by using amino-modified reduced graphene oxide loaded with N-doped carbon quantum dots.	Amino Acids	73-78	enolase 2	Homo sapiens	40-63
31633715-1	2019	Single-crystal-to-single-crystal (SC-SC) structural self-evolution has been successfully performed on an amino-functionalized MOF material, which has greatly improved the Hg2+ removal performance of the material and implemented dye molecule encapsulation through a dissolution-encapsulation-recrystallization process for the first time.	Amino Acids	105-110	lysine acetyltransferase 8	Homo sapiens	126-129
31591270-8	2019	A peptide comprising residues 2-17 of ARF1 ([2-17]ARF1) inhibited GAP activity and PIP2-dependently bound to a protein containing the PH domain and a 17-amino-acid-long interdomain linker immediately N-terminal to the first beta-strand of the PH domain.	Amino Acids	150-163	ADP ribosylation factor 1	Homo sapiens	50-54
31722207-2	2019	The amino-terminal domain of MX2 binds the viral capsid and is essential for inhibition.	Amino Acids	4-9	MX dynamin like GTPase 2	Homo sapiens	29-32
31741852-5	2019	This reduced viability was prevented by treating the cells after initial insult with the 20-amino acid renalase derived peptide (RP-220).	Amino Acids	89-102	renalase, FAD dependent amine oxidase	Homo sapiens	103-111
31722207-4	2019	The importance of this interaction was addressed in competition assays using the naturally occurring non-antiviral short isoform of MX2 that lacks the amino-terminal 25 amino acids.	Amino Acids	151-156	MX dynamin like GTPase 2	Homo sapiens	132-135
31591268-8	2019	aaRS, EF-Tu, and the ribosome act as "chiral checkpoints" by preferentially binding to l-amino acids or l-aminoacyl-tRNAs, thereby excluding d-amino acids.	Amino Acids	87-100	alanyl-tRNA synthetase 1	Homo sapiens	0-4
31670727-0	2019	A porous and redox active ferrocenedicarboxylic acid based aluminium MOF with a MIL-53 architecture.	Amino Acids	26-52	lysine acetyltransferase 8	Homo sapiens	69-72
31591268-8	2019	aaRS, EF-Tu, and the ribosome act as "chiral checkpoints" by preferentially binding to l-amino acids or l-aminoacyl-tRNAs, thereby excluding d-amino acids.	Amino Acids	87-100	Tu translation elongation factor, mitochondrial	Homo sapiens	6-11
31703269-1	2019	Commercial gonadotropin-releasing hormone (GnRH) antagonists differ by 1-2 amino acids and are used to inhibit gonadotropin production during assisted reproduction technologies (ART).	Amino Acids	71-86	gonadotropin releasing hormone 1	Homo sapiens	43-47
31642665-1	2019	A new three-dimensional metal-organic framework (MOF) was synthesized by linking ditopic amino functionalized polyoxometalate [N(C4H9)4]3[MnMo6O18{(OCH2)3CNH2}2] with 4-connected tetrahedral tetrakis(4-formylphenyl)methane building units through imine condensation.	Amino Acids	89-94	lysine acetyltransferase 8	Homo sapiens	24-53
31719171-7	2019	Expression of various mutant forms of the PI3Kgamma catalytic subunit (p110gamma) in cells lacking PI3Kgamma revealed that only the noncatalytic, amino-terminal domain of p110gamma was necessary and sufficient for TGF-beta-induced TRPV4 plasma membrane recruitment and myofibroblast transdifferentiation.	Amino Acids	146-151	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	42-51
31563414-0	2019	Identification of recombinant AtPYL2, an abscisic acid receptor, in E. coli using a substrate-derived bioactive small molecule, a biotin linker with alkyne and amino groups, and a protein cross-linker.	Amino Acids	160-165	PYR1-like 2	Arabidopsis thaliana	30-36
31719171-7	2019	Expression of various mutant forms of the PI3Kgamma catalytic subunit (p110gamma) in cells lacking PI3Kgamma revealed that only the noncatalytic, amino-terminal domain of p110gamma was necessary and sufficient for TGF-beta-induced TRPV4 plasma membrane recruitment and myofibroblast transdifferentiation.	Amino Acids	146-151	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	171-180
31542717-2	2019	Specifically, the substituted amino moiety containing mono or poly alkoxy group(s) with various positions and groups were mainly explored to understand the structure-activity relationships for the cytotoxic activity against three human cancer cell lines (K562, Jurkat, and MT-2) and human peripheral blood mononuclear cells (PBMC).	Amino Acids	30-35	metallothionein 2A	Homo sapiens	273-277
31674342-7	2019	The in vitro higher uptake of MTX-GC-SA in murine macrophage cells (RAW 264.7) was confirmed using confocal microscopy and FACS analysis.	Amino Acids	37-39	acyl-CoA synthetase long-chain family member 1	Mus musculus	123-127
31593795-0	2019	Targeted co-delivery of Trp-2 polypeptide and monophosphoryl lipid A by pH-sensitive poly (beta-amino ester) nano-vaccines for melanoma.	Amino Acids	91-107	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	24-29
31685992-4	2019	We also show that USP9X and FBXW11 bind to the amino-terminal extensions of PTENalpha/beta, and respectively deubiquitinate and ubiquitinate lysines 235 and 239 in PTENalpha to regulate PTENalpha/beta stability.	Amino Acids	47-52	ubiquitin specific peptidase 9 X-linked	Homo sapiens	18-23
31685992-4	2019	We also show that USP9X and FBXW11 bind to the amino-terminal extensions of PTENalpha/beta, and respectively deubiquitinate and ubiquitinate lysines 235 and 239 in PTENalpha to regulate PTENalpha/beta stability.	Amino Acids	47-52	F-box and WD repeat domain containing 11	Homo sapiens	28-34
31686052-4	2019	A 2.4 -A resolution crystal structure reveals that human MYC amino acids 98-111 interact with TBP in the presence of the amino-terminal domain 1 of TBP-associated factor 1 (TAF1TAND1).	Amino Acids	61-66	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	57-60
31686052-4	2019	A 2.4 -A resolution crystal structure reveals that human MYC amino acids 98-111 interact with TBP in the presence of the amino-terminal domain 1 of TBP-associated factor 1 (TAF1TAND1).	Amino Acids	61-66	TATA-box binding protein	Homo sapiens	94-97
31686052-4	2019	A 2.4 -A resolution crystal structure reveals that human MYC amino acids 98-111 interact with TBP in the presence of the amino-terminal domain 1 of TBP-associated factor 1 (TAF1TAND1).	Amino Acids	61-66	TATA-box binding protein	Homo sapiens	148-151
31717764-2	2019	Some of them were obtained by reaction of substitution involving the two phenolic OH groups of curcumin while the analogues with a substituent at C-4 was prepared following an original procedure that regards the condensation of benzenesulfenic acid onto the nucleophilic central carbon of the curcumin skeleton.	Amino Acids	228-248	complement C4A (Rodgers blood group)	Homo sapiens	146-149
31781296-7	2019	DRB1*01, DRB1*09, DRB1*11, DRB1*12, and DRB1*16 alleles were protective, in agreement with the type of amino-acidic (aa) residues (ranging from position 9 to 90) included in pockets 1, 4, 6, 7, and 9, which are most involved in peptide presentation.	Amino Acids	103-108	major histocompatibility complex, class II, DR beta 1	Homo sapiens	0-4
31694264-1	2019	In this study, we investigated a mechanistic link between Na-H exchanger-1 (NHE-1) and carbonic anhydrase (CA) in experimental colitis induced in the rats by intrarectal administration of trinitrobenzenesulphonic acid (TNBS).	Amino Acids	188-217	solute carrier family 9 member A1	Rattus norvegicus	58-74
31694264-1	2019	In this study, we investigated a mechanistic link between Na-H exchanger-1 (NHE-1) and carbonic anhydrase (CA) in experimental colitis induced in the rats by intrarectal administration of trinitrobenzenesulphonic acid (TNBS).	Amino Acids	188-217	solute carrier family 9 member A1	Rattus norvegicus	76-81
31694264-1	2019	In this study, we investigated a mechanistic link between Na-H exchanger-1 (NHE-1) and carbonic anhydrase (CA) in experimental colitis induced in the rats by intrarectal administration of trinitrobenzenesulphonic acid (TNBS).	Amino Acids	219-223	solute carrier family 9 member A1	Rattus norvegicus	76-81
31694264-4	2019	TNBS significantly reduced the levels of NHE-1 and CA protein isoforms in the colon, but not in the uninflamed ileum.	Amino Acids	0-4	solute carrier family 9 member A1	Rattus norvegicus	41-46
31690022-4	2019	The extract also inhibited the IL-1beta-induced translocation of NF-kappaB/p65 into the nucleus and dose-dependent phosphorylation levels of extracellular signal-regulated kinase (ERK), Jun amino-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase.	Amino Acids	190-195	interleukin 1 beta	Rattus norvegicus	31-39
31652622-0	2019	Amino-3,5-Dicyanopyridines Targeting the Adenosine Receptors Ranging from Pan Ligands to Combined A1/A2B Partial Agonists.	Amino Acids	0-26	BCL2 related protein A1	Homo sapiens	98-104
31581697-6	2019	At the molecular level, SA treatment exerts an increase in skeletal muscle expression levels of membrane glucose transporter 4 (GLUT4) and phospho-Akt to increase the membrane glucose uptake, but the mRNA levels of PEPCK and G6Pase are decreased to inhibit hepatic glucose production, thus leading to its hypoglycemic effect.	Amino Acids	24-26	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	105-126
31617627-7	2019	To the best of our knowledge, compound 4h is the first LSD1 inhibitor derived from unnatural alpha-arylated amino esters, and therefore could be used as a hit compound for the development of new LSD1 inhibitors.	Amino Acids	93-120	lysine demethylase 1A	Homo sapiens	55-59
31581697-6	2019	At the molecular level, SA treatment exerts an increase in skeletal muscle expression levels of membrane glucose transporter 4 (GLUT4) and phospho-Akt to increase the membrane glucose uptake, but the mRNA levels of PEPCK and G6Pase are decreased to inhibit hepatic glucose production, thus leading to its hypoglycemic effect.	Amino Acids	24-26	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	128-133
31581697-6	2019	At the molecular level, SA treatment exerts an increase in skeletal muscle expression levels of membrane glucose transporter 4 (GLUT4) and phospho-Akt to increase the membrane glucose uptake, but the mRNA levels of PEPCK and G6Pase are decreased to inhibit hepatic glucose production, thus leading to its hypoglycemic effect.	Amino Acids	24-26	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	215-220
31581697-6	2019	At the molecular level, SA treatment exerts an increase in skeletal muscle expression levels of membrane glucose transporter 4 (GLUT4) and phospho-Akt to increase the membrane glucose uptake, but the mRNA levels of PEPCK and G6Pase are decreased to inhibit hepatic glucose production, thus leading to its hypoglycemic effect.	Amino Acids	24-26	glucose-6-phosphatase, catalytic	Mus musculus	225-231
31581697-7	2019	Moreover, SA may cause hypolipidemic effects not only by enhancing hepatic expression levels of peroxisome proliferator-activated receptor alpha (PPARalpha) with increased fatty acid oxidation but also by reducing lipogenic fatty acid synthase (FAS) as well as reducing mRNA levels of sterol regulatory element binding protein (SREBP)1C and SREBP2 to lower blood TG and TC levels.	Amino Acids	10-12	peroxisome proliferator activated receptor alpha	Mus musculus	96-144
31581697-7	2019	Moreover, SA may cause hypolipidemic effects not only by enhancing hepatic expression levels of peroxisome proliferator-activated receptor alpha (PPARalpha) with increased fatty acid oxidation but also by reducing lipogenic fatty acid synthase (FAS) as well as reducing mRNA levels of sterol regulatory element binding protein (SREBP)1C and SREBP2 to lower blood TG and TC levels.	Amino Acids	10-12	peroxisome proliferator activated receptor alpha	Mus musculus	146-155
31581697-7	2019	Moreover, SA may cause hypolipidemic effects not only by enhancing hepatic expression levels of peroxisome proliferator-activated receptor alpha (PPARalpha) with increased fatty acid oxidation but also by reducing lipogenic fatty acid synthase (FAS) as well as reducing mRNA levels of sterol regulatory element binding protein (SREBP)1C and SREBP2 to lower blood TG and TC levels.	Amino Acids	10-12	fatty acid synthase	Mus musculus	224-243
31581697-7	2019	Moreover, SA may cause hypolipidemic effects not only by enhancing hepatic expression levels of peroxisome proliferator-activated receptor alpha (PPARalpha) with increased fatty acid oxidation but also by reducing lipogenic fatty acid synthase (FAS) as well as reducing mRNA levels of sterol regulatory element binding protein (SREBP)1C and SREBP2 to lower blood TG and TC levels.	Amino Acids	10-12	fatty acid synthase	Mus musculus	245-248
31581697-7	2019	Moreover, SA may cause hypolipidemic effects not only by enhancing hepatic expression levels of peroxisome proliferator-activated receptor alpha (PPARalpha) with increased fatty acid oxidation but also by reducing lipogenic fatty acid synthase (FAS) as well as reducing mRNA levels of sterol regulatory element binding protein (SREBP)1C and SREBP2 to lower blood TG and TC levels.	Amino Acids	10-12	sterol regulatory element binding transcription factor 1	Mus musculus	328-336
31581697-7	2019	Moreover, SA may cause hypolipidemic effects not only by enhancing hepatic expression levels of peroxisome proliferator-activated receptor alpha (PPARalpha) with increased fatty acid oxidation but also by reducing lipogenic fatty acid synthase (FAS) as well as reducing mRNA levels of sterol regulatory element binding protein (SREBP)1C and SREBP2 to lower blood TG and TC levels.	Amino Acids	10-12	sterol regulatory element binding factor 2	Mus musculus	341-347
31620232-4	2019	Introduction of a variety of natural or unnatural amino acids to the 3-amino group gave us the more potent derivative 13x which has about four times higher readthrough activity than 7 in a cell-based assay using a premature termination codon of TGA derived from Duchenne muscular dystrophy.	Amino Acids	69-76	T-box transcription factor 1	Homo sapiens	245-248
31599264-6	2019	His serum Alpha-Feto Protein (AFP) level was very high with elevated serum alanine amino transaminase (ALT) enzyme and prothrombin time.	Amino Acids	83-88	alpha fetoprotein	Homo sapiens	10-28
31599264-6	2019	His serum Alpha-Feto Protein (AFP) level was very high with elevated serum alanine amino transaminase (ALT) enzyme and prothrombin time.	Amino Acids	83-88	alpha fetoprotein	Homo sapiens	30-33
31749906-0	2019	Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.	Amino Acids	13-32	indoleamine 2,3-dioxygenase 1	Homo sapiens	41-70
31749906-0	2019	Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy.	Amino Acids	13-32	indoleamine 2,3-dioxygenase 1	Homo sapiens	72-76
31749906-4	2019	Here, we report the discovery of a class of IDO1 heme-binding inhibitors featuring a unique amino-cyclobutarene motif, which was discovered through SBDD from a known and weakly active inhibitor.	Amino Acids	92-111	indoleamine 2,3-dioxygenase 1	Homo sapiens	44-48
31492955-1	2019	L-Type Amino Acid Transporter 1 (LAT1/Lat1) is responsible for carrying large, neutral L-amino acids as well as several drugs and prodrugs across the blood-brain barrier (BBB).	Amino Acids	87-100	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	0-31
31391235-5	2019	We prepared a library of analogues of MHC-II-binding peptides derived from OVA, in which at least one alpha-amino acid residue was replaced with a homologous beta-amino acid residue.	Amino Acids	102-118	histocompatibility-2, MHC	Mus musculus	38-44
31492955-1	2019	L-Type Amino Acid Transporter 1 (LAT1/Lat1) is responsible for carrying large, neutral L-amino acids as well as several drugs and prodrugs across the blood-brain barrier (BBB).	Amino Acids	87-100	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	33-37
31492955-1	2019	L-Type Amino Acid Transporter 1 (LAT1/Lat1) is responsible for carrying large, neutral L-amino acids as well as several drugs and prodrugs across the blood-brain barrier (BBB).	Amino Acids	87-100	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	38-42
31565603-4	2019	Molecular features commonly found in prostate adenocarcinomas are now well-recognized, including defects in homologous recombination (HR) genes, like breast cancer type 2 susceptibility protein (BRCA2), leading to increased sensitivity to deoxyribonucleic acid (DNA)-damaging agents (e.g., platinum chemotherapy or poly adenosine diphosphate-ribose polymerase (PARP) inhibitors).	Amino Acids	239-260	BRCA2 DNA repair associated	Homo sapiens	150-193
31564976-12	2019	Mechanistic study showed that upregulation of HOXC6 significantly increased the phosphorylation of Jun amino-terminal kinase, ERK and P38, as well as the expression of mitogen-activated protein kinase (MAPK) signaling-related genes, including c-myc, c-jun and p53.	Amino Acids	103-108	homeobox C6	Homo sapiens	46-51
31406120-5	2019	Furthermore, the sensitivity of AmGr10 to these L-amino acids was dramatically enhanced by purine ribonucleotides, like inosine-5"-monophosphate (IMP).	Amino Acids	48-61	gustatory receptor 10	Apis mellifera	32-38
31078752-2	2019	An effective strategy to control the formation of N-DBPs is to reduce their nitrogenous precursors (e.g., amino acids [AAs], believed to be the important N-DBP precursors) before disinfection.	Amino Acids	119-122	D-box binding PAR bZIP transcription factor	Homo sapiens	52-55
31565603-4	2019	Molecular features commonly found in prostate adenocarcinomas are now well-recognized, including defects in homologous recombination (HR) genes, like breast cancer type 2 susceptibility protein (BRCA2), leading to increased sensitivity to deoxyribonucleic acid (DNA)-damaging agents (e.g., platinum chemotherapy or poly adenosine diphosphate-ribose polymerase (PARP) inhibitors).	Amino Acids	239-260	BRCA2 DNA repair associated	Homo sapiens	195-200
31565603-4	2019	Molecular features commonly found in prostate adenocarcinomas are now well-recognized, including defects in homologous recombination (HR) genes, like breast cancer type 2 susceptibility protein (BRCA2), leading to increased sensitivity to deoxyribonucleic acid (DNA)-damaging agents (e.g., platinum chemotherapy or poly adenosine diphosphate-ribose polymerase (PARP) inhibitors).	Amino Acids	239-260	poly(ADP-ribose) polymerase 1	Homo sapiens	315-359
31565603-4	2019	Molecular features commonly found in prostate adenocarcinomas are now well-recognized, including defects in homologous recombination (HR) genes, like breast cancer type 2 susceptibility protein (BRCA2), leading to increased sensitivity to deoxyribonucleic acid (DNA)-damaging agents (e.g., platinum chemotherapy or poly adenosine diphosphate-ribose polymerase (PARP) inhibitors).	Amino Acids	239-260	poly(ADP-ribose) polymerase 1	Homo sapiens	361-365
31565603-4	2019	Molecular features commonly found in prostate adenocarcinomas are now well-recognized, including defects in homologous recombination (HR) genes, like breast cancer type 2 susceptibility protein (BRCA2), leading to increased sensitivity to deoxyribonucleic acid (DNA)-damaging agents (e.g., platinum chemotherapy or poly adenosine diphosphate-ribose polymerase (PARP) inhibitors).	Amino Acids	262-265	BRCA2 DNA repair associated	Homo sapiens	150-193
31565603-4	2019	Molecular features commonly found in prostate adenocarcinomas are now well-recognized, including defects in homologous recombination (HR) genes, like breast cancer type 2 susceptibility protein (BRCA2), leading to increased sensitivity to deoxyribonucleic acid (DNA)-damaging agents (e.g., platinum chemotherapy or poly adenosine diphosphate-ribose polymerase (PARP) inhibitors).	Amino Acids	262-265	BRCA2 DNA repair associated	Homo sapiens	195-200
31127815-0	2019	L-Amino Acids Promote Calcitonin Release via a Calcium-Sensing Receptor: Gq/11-Mediated Pathway in Human C-Cells.	Amino Acids	0-13	calcitonin related polypeptide alpha	Homo sapiens	22-32
31737421-0	2019	Tannic Acid Accelerates Cutaneous Wound Healing in Rats Via Activation of the ERK 1/2 Signaling Pathways.	Amino Acids	0-11	mitogen activated protein kinase 3	Rattus norvegicus	78-85
31737421-6	2019	The levels of growth factors including basic fibroblast growth factor (bFGF), transforming growth factor-beta, and vascular endothelial growth factor in TA-treated groups were all increased, and the content of interleukin-1 (IL-1) and IL-6 was decreased significantly when compared with that of the untreated group.	Amino Acids	153-155	fibroblast growth factor 2	Rattus norvegicus	71-75
31737421-6	2019	The levels of growth factors including basic fibroblast growth factor (bFGF), transforming growth factor-beta, and vascular endothelial growth factor in TA-treated groups were all increased, and the content of interleukin-1 (IL-1) and IL-6 was decreased significantly when compared with that of the untreated group.	Amino Acids	153-155	interleukin 6	Rattus norvegicus	235-239
31737421-7	2019	The NIH 3T3 cells grow faster in 6 h at concentration of 0.1 mug/mL, and the expression of bFGF in gene and protein was increased significantly in the 0.1 mug/mL TA group.	Amino Acids	162-164	fibroblast growth factor 2	Mus musculus	91-95
31737421-8	2019	Further study revealed that the protein levels of bFGF, extracellular signal regulated kinase (Erk) 1/2, and P-Erk 1/2 in Erk 1/2 pathway were increased after TA treatment.	Amino Acids	159-161	fibroblast growth factor 2	Rattus norvegicus	50-54
31737421-8	2019	Further study revealed that the protein levels of bFGF, extracellular signal regulated kinase (Erk) 1/2, and P-Erk 1/2 in Erk 1/2 pathway were increased after TA treatment.	Amino Acids	159-161	mitogen activated protein kinase 3	Rattus norvegicus	56-103
31737421-8	2019	Further study revealed that the protein levels of bFGF, extracellular signal regulated kinase (Erk) 1/2, and P-Erk 1/2 in Erk 1/2 pathway were increased after TA treatment.	Amino Acids	159-161	mitogen activated protein kinase 3	Rattus norvegicus	111-118
31737421-8	2019	Further study revealed that the protein levels of bFGF, extracellular signal regulated kinase (Erk) 1/2, and P-Erk 1/2 in Erk 1/2 pathway were increased after TA treatment.	Amino Acids	159-161	mitogen activated protein kinase 3	Rattus norvegicus	122-129
31737421-10	2019	Conclusion: These results suggested that TA could accelerate wound healing through modulation of inflammatory cytokines and growth factors and activate Erk 1/2 pathway.	Amino Acids	41-43	mitogen activated protein kinase 3	Rattus norvegicus	152-159
31127815-0	2019	L-Amino Acids Promote Calcitonin Release via a Calcium-Sensing Receptor: Gq/11-Mediated Pathway in Human C-Cells.	Amino Acids	0-13	calcium sensing receptor	Homo sapiens	47-71
31127815-7	2019	The findings support the hypothesis that calcitonin release is stimulated by increases in plasma L-amino acid levels as well as elevated Ca2+o concentration.	Amino Acids	97-109	calcitonin related polypeptide alpha	Homo sapiens	41-51
30753403-8	2019	GPRC6A is a class C G protein-coupled receptor activated by l-alpha-amino acids and is modulated by calcium.	Amino Acids	60-79	G protein-coupled receptor class C group 6 member A	Homo sapiens	0-6
31943904-2	2019	Their reaction with cis-Ru(bpy)2 Cl2 (bpy=2,2"-bipyridine) was investigated and Ru(bpy)2 (L)(PF6 )2 (phen=1,10-phenanthroline) (L=amino-substituted 1,10-phenanthroline) complexes were obtained in good yields.	Amino Acids	130-135	endogenous retrovirus group W member 5	Homo sapiens	33-36
31943904-2	2019	Their reaction with cis-Ru(bpy)2 Cl2 (bpy=2,2"-bipyridine) was investigated and Ru(bpy)2 (L)(PF6 )2 (phen=1,10-phenanthroline) (L=amino-substituted 1,10-phenanthroline) complexes were obtained in good yields.	Amino Acids	130-135	sperm associated antigen 17	Homo sapiens	93-96
30604098-3	2019	The functionality of this conserved Gly residue in the insulin family has been studied by replacing it with natural L-amino acids or the corresponding unnatural D-amino acids.	Amino Acids	116-129	insulin	Homo sapiens	55-62
30885989-1	2019	Several amino acids (AAs) have been shown to be associated with insulin resistance and increased risk of type 2 diabetes, but no previous studies have investigated the association of AAs with insulin secretion in a longitudinal setting.	Amino Acids	21-24	insulin	Homo sapiens	64-71
30784887-8	2019	The detection limits for AAs range from 0.13 to 0.37 mug mL-1 using the SPE/CE method.	Amino Acids	25-28	L1 cell adhesion molecule	Mus musculus	57-61
30691159-3	2019	For instance, l-alpha-amino acids with artificial, bulky side chains are poorer substrates for ribosomal incorporation into the nascent peptide chain, mainly owing to the lower affinity of their aminoacyl-tRNA toward elongation factor-thermo unstable (EF-Tu).	Amino Acids	14-33	Tu translation elongation factor, mitochondrial	Homo sapiens	252-257
31737223-4	2019	In this study, we developed paclitaxel amino lipid (PAL) derived nanoparticles (NPs) to incorporate both chemotherapy drugs and P53 mRNA.	Amino Acids	39-44	transformation related protein 53, pseudogene	Mus musculus	128-131
30433825-2	2019	l-Amino acid oxidase 1 (LAO1) is a flavoprotein that catalyzes the oxidative deamination of particular l-amino acids and converts them into keto acids, ammonia, and H2O2.	Amino Acids	103-116	L-amino acid oxidase 1	Mus musculus	0-22
30433825-2	2019	l-Amino acid oxidase 1 (LAO1) is a flavoprotein that catalyzes the oxidative deamination of particular l-amino acids and converts them into keto acids, ammonia, and H2O2.	Amino Acids	103-116	L-amino acid oxidase 1	Mus musculus	24-28
30702883-4	2019	On the other hand, alpha-amino acid derivatives of N-isoxazolescan be obtained through N-H insertion reactions in the presence of catalytic Rh2(Oct)4.	Amino Acids	19-35	Rh associated glycoprotein	Homo sapiens	140-143
30699288-7	2019	Because the PLP-binding lysine in ODC, LODC, DAPDC, and DOKDC is located on the re-face of the PLP, we propose that this is the acid group responsible for protonation of the product, thus resulting in the observed retention of configuration for decarboxylation of l-amino acids and inversion for decarboxylation of d-amino acids.	Amino Acids	264-277	ornithine decarboxylase 1	Homo sapiens	34-37
30795505-5	2019	The human HAT 4F2hc-LAT2 (SLC3A2-SLC7A8) is specific for the transport of large neutral L-amino acids and specific amino acid-related compounds.	Amino Acids	88-101	solute carrier family 3 member 2	Homo sapiens	14-19
30795505-5	2019	The human HAT 4F2hc-LAT2 (SLC3A2-SLC7A8) is specific for the transport of large neutral L-amino acids and specific amino acid-related compounds.	Amino Acids	88-101	linker for activation of T cells family member 2	Homo sapiens	20-24
30795505-5	2019	The human HAT 4F2hc-LAT2 (SLC3A2-SLC7A8) is specific for the transport of large neutral L-amino acids and specific amino acid-related compounds.	Amino Acids	88-101	solute carrier family 3 member 2	Homo sapiens	26-32
30795505-5	2019	The human HAT 4F2hc-LAT2 (SLC3A2-SLC7A8) is specific for the transport of large neutral L-amino acids and specific amino acid-related compounds.	Amino Acids	88-101	solute carrier family 7 member 8	Homo sapiens	33-39
31695954-6	2019	Furthermore, DSE significantly reduced the phosphorylation of c-Jun amino terminal kinase.	Amino Acids	68-73	jun proto-oncogene	Mus musculus	62-67
30673214-3	2019	Herein it is demonstrated that AbmH is a pyridoxal 5"-phosphate (PLP)-dependent transaldolase that catalyzes a threo-selective aldol-type reaction to generate the thioheptose core with a d-ribofuranose ring and an l-amino acid moiety.	Amino Acids	214-226	pyridoxal phosphatase	Homo sapiens	65-68
30088839-2	2018	Calcium-sensing receptor (CaSR) is involved in regulating gut hormone secretion in response to l-amino acids and multivalent cations.	Amino Acids	95-108	calcium sensing receptor	Sus scrofa	0-24
30102931-2	2018	Our recent study demonstrated that selectivity of the chimeric relaxin family peptide R3/I5 towards the homologous RXFP3 and RXFP4 can be modulated by replacement of the highly conserved nonchiral B23Gly or B24Gly with some natural l-amino acids.	Amino Acids	232-245	relaxin family peptide receptor 3	Homo sapiens	115-120
30102931-2	2018	Our recent study demonstrated that selectivity of the chimeric relaxin family peptide R3/I5 towards the homologous RXFP3 and RXFP4 can be modulated by replacement of the highly conserved nonchiral B23Gly or B24Gly with some natural l-amino acids.	Amino Acids	232-245	relaxin family peptide/INSL5 receptor 4	Homo sapiens	125-130
30102931-8	2018	l-amino acids with an appropriate size, such as L-Ser and L-Abu, had the greatest effect on increasing the selectivity of R3/I5 towards RXFP3 over the homologous RXFP4.	Amino Acids	0-13	relaxin family peptide receptor 3	Homo sapiens	136-141
30102931-8	2018	l-amino acids with an appropriate size, such as L-Ser and L-Abu, had the greatest effect on increasing the selectivity of R3/I5 towards RXFP3 over the homologous RXFP4.	Amino Acids	0-13	relaxin family peptide/INSL5 receptor 4	Homo sapiens	162-167
30982802-1	2019	T1R1 and T1R3 are receptors expressed in taste buds that detect L-amino acids.	Amino Acids	64-77	taste receptor, type 1, member 1	Mus musculus	0-4
30982802-1	2019	T1R1 and T1R3 are receptors expressed in taste buds that detect L-amino acids.	Amino Acids	64-77	taste receptor, type 1, member 3	Mus musculus	9-13
32030362-3	2019	Tumors deficient in deoxyribonucleic acid (DNA) damage repair mechanisms such as BRCA mutants show better responses to platinum based agents, however, such tumors can utilize the poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) pathway as a salvage mechanism.	Amino Acids	20-41	BRCA1 DNA repair associated	Homo sapiens	81-85
32030362-3	2019	Tumors deficient in deoxyribonucleic acid (DNA) damage repair mechanisms such as BRCA mutants show better responses to platinum based agents, however, such tumors can utilize the poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) pathway as a salvage mechanism.	Amino Acids	20-41	collagen type XI alpha 2 chain	Homo sapiens	232-236
32030362-3	2019	Tumors deficient in deoxyribonucleic acid (DNA) damage repair mechanisms such as BRCA mutants show better responses to platinum based agents, however, such tumors can utilize the poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) pathway as a salvage mechanism.	Amino Acids	43-46	BRCA1 DNA repair associated	Homo sapiens	81-85
32030362-3	2019	Tumors deficient in deoxyribonucleic acid (DNA) damage repair mechanisms such as BRCA mutants show better responses to platinum based agents, however, such tumors can utilize the poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) pathway as a salvage mechanism.	Amino Acids	43-46	collagen type XI alpha 2 chain	Homo sapiens	232-236
30152580-4	2018	The obtained adducts were smoothly coupled with alpha-amino acid-derived alpha-ketoacids to afford alpha/beta2, 2 -hybrid dipeptides suitable for 9-fluorenylmethoxycarbonyl (Fmoc)-based solid-phase peptide synthesis.	Amino Acids	48-64	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	99-110
30088839-2	2018	Calcium-sensing receptor (CaSR) is involved in regulating gut hormone secretion in response to l-amino acids and multivalent cations.	Amino Acids	95-108	calcium sensing receptor	Sus scrofa	26-30
29601913-9	2018	CONCLUSIONS: The increase in fasting serum AAs can be an early manifestation of insulin resistance.	Amino Acids	43-46	insulin	Homo sapiens	80-87
29168280-5	2018	The N-O bond in the products not only acts as a traceless protecting group for beta-amino acids but also undergoes amide formation with alpha-ketoacids derived from Fmoc-protected alpha-amino acids, thus providing expeditious access to alpha-beta2,2 -dipeptides ready for Fmoc-SPPS.	Amino Acids	180-197	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	242-249
29266399-5	2018	Experiments performed in mice carrying hepatocyte-specific deletion of HIF-2alpha and related control littermates fed either a choline-deficient L-amino acid-defined or a methionine/choline-deficient diet showed that HIF-2alpha deletion ameliorated the evolution of NAFLD by decreasing parenchymal injury, fatty liver, lobular inflammation, and the development of liver fibrosis.	Amino Acids	145-157	endothelial PAS domain protein 1	Mus musculus	71-81
29610403-3	2018	In humans, only cationic aminoaciduria due to malfunction of the basolateral transporter y+LAT1/CD98hc (SLC7A7/SLC3A2), which mediates the export of cationic AAs, has been described.	Amino Acids	158-161	solute carrier family 7 member 5	Homo sapiens	91-95
29610403-3	2018	In humans, only cationic aminoaciduria due to malfunction of the basolateral transporter y+LAT1/CD98hc (SLC7A7/SLC3A2), which mediates the export of cationic AAs, has been described.	Amino Acids	158-161	solute carrier family 3 member 2	Homo sapiens	96-102
29610403-3	2018	In humans, only cationic aminoaciduria due to malfunction of the basolateral transporter y+LAT1/CD98hc (SLC7A7/SLC3A2), which mediates the export of cationic AAs, has been described.	Amino Acids	158-161	solute carrier family 7 member 7	Homo sapiens	104-110
29610403-3	2018	In humans, only cationic aminoaciduria due to malfunction of the basolateral transporter y+LAT1/CD98hc (SLC7A7/SLC3A2), which mediates the export of cationic AAs, has been described.	Amino Acids	158-161	solute carrier family 3 member 2	Homo sapiens	111-117
29610403-4	2018	Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear.	Amino Acids	67-70	solute carrier family 3 member 2	Homo sapiens	100-106
29610403-4	2018	Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear.	Amino Acids	67-70	solute carrier family 7 (cationic amino acid transporter, y+ system), member 8	Mus musculus	108-114
29610403-4	2018	Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear.	Amino Acids	67-70	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	Mus musculus	115-121
29610403-4	2018	Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear.	Amino Acids	67-70	solute carrier family 16 (monocarboxylic acid transporters), member 10	Mus musculus	187-191
29610403-4	2018	Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear.	Amino Acids	67-70	solute carrier family 16 (monocarboxylic acid transporters), member 10	Mus musculus	193-201
29610403-4	2018	Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear.	Amino Acids	164-167	linker for activation of T cells family, member 2	Mus musculus	95-99
29610403-4	2018	Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear.	Amino Acids	164-167	solute carrier family 3 member 2	Homo sapiens	100-106
29610403-4	2018	Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear.	Amino Acids	164-167	solute carrier family 7 (cationic amino acid transporter, y+ system), member 8	Mus musculus	108-114
29610403-4	2018	Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear.	Amino Acids	164-167	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	Mus musculus	115-121
29610403-4	2018	Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear.	Amino Acids	164-167	linker for activation of T cells family, member 2	Mus musculus	95-99
29610403-4	2018	Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear.	Amino Acids	164-167	solute carrier family 3 member 2	Homo sapiens	100-106
29610403-4	2018	Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear.	Amino Acids	164-167	solute carrier family 7 (cationic amino acid transporter, y+ system), member 8	Mus musculus	108-114
29610403-4	2018	Thus, the physiologic roles of basolateral transporters of neutral AAs, such as the antiporter LAT2/CD98hc (SLC7A8/SLC3A2), a heterodimer that exports most neutral AAs, and the uniporter TAT1 (SLC16A10), which exports only aromatic AAs, remain unclear.	Amino Acids	164-167	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	Mus musculus	115-121
29760499-4	2018	Our data indicate that chemokine Ccl5 is one of the HSC-secreted mediators in early NASH in humans and in mice fed with choline-deficient, L-amino acid defined, high fat diet.	Amino Acids	139-151	C-C motif chemokine ligand 5	Homo sapiens	33-37
29567365-1	2018	Because d-amino acids (AAs) play an essential role in the regulation of many processes in living cells, detection of D-AAs and assay of d-amino acid oxidase (DAAO) activity are of vital importance in bioanalytical science.	Amino Acids	23-26	D-amino acid oxidase	Homo sapiens	136-156
29567365-1	2018	Because d-amino acids (AAs) play an essential role in the regulation of many processes in living cells, detection of D-AAs and assay of d-amino acid oxidase (DAAO) activity are of vital importance in bioanalytical science.	Amino Acids	23-26	D-amino acid oxidase	Homo sapiens	158-162
29467657-1	2018	The SNAT2 (SLC38A2) System A amino acid transporter mediates Na+-coupled cellular uptake of small neutral alpha-amino acids (AAs) and is extensively regulated in response to humoral and nutritional cues.	Amino Acids	106-123	solute carrier family 38 member 2	Homo sapiens	4-9
29467657-1	2018	The SNAT2 (SLC38A2) System A amino acid transporter mediates Na+-coupled cellular uptake of small neutral alpha-amino acids (AAs) and is extensively regulated in response to humoral and nutritional cues.	Amino Acids	106-123	solute carrier family 38 member 2	Homo sapiens	11-18
29467657-1	2018	The SNAT2 (SLC38A2) System A amino acid transporter mediates Na+-coupled cellular uptake of small neutral alpha-amino acids (AAs) and is extensively regulated in response to humoral and nutritional cues.	Amino Acids	106-123	solute carrier family 38 member 7	Homo sapiens	29-51
29467657-1	2018	The SNAT2 (SLC38A2) System A amino acid transporter mediates Na+-coupled cellular uptake of small neutral alpha-amino acids (AAs) and is extensively regulated in response to humoral and nutritional cues.	Amino Acids	125-128	solute carrier family 38 member 2	Homo sapiens	4-9
29467657-1	2018	The SNAT2 (SLC38A2) System A amino acid transporter mediates Na+-coupled cellular uptake of small neutral alpha-amino acids (AAs) and is extensively regulated in response to humoral and nutritional cues.	Amino Acids	125-128	solute carrier family 38 member 2	Homo sapiens	11-18
29467657-1	2018	The SNAT2 (SLC38A2) System A amino acid transporter mediates Na+-coupled cellular uptake of small neutral alpha-amino acids (AAs) and is extensively regulated in response to humoral and nutritional cues.	Amino Acids	125-128	solute carrier family 38 member 7	Homo sapiens	29-51
29262256-5	2018	We herein report the generation of a head-to-tail interferon-poly(alpha-amino acid) macrocycle conjugate circ-P(EG3Glu)20-IFN by combining the aforementioned two approaches.	Amino Acids	65-83	interferon alpha 1	Homo sapiens	122-125
29468843-7	2018	Using structural models of the venus fly trap (VFT) and 7-transmembrane (7-TM) domains of GPRC6A, calculations suggest that l-amino acids and GA bind to the VFT, whereas EGCG is calculated to bind to sites in both the VFT and 7-TM.	Amino Acids	124-137	G protein-coupled receptor class C group 6 member A	Homo sapiens	90-96
29407871-3	2018	LAAO converts L-amino acid into alpha-keto acid and release ammonia and hydrogen peroxide as by-products.	Amino Acids	14-26	interleukin 4 induced 1	Homo sapiens	0-4
28802074-1	2018	Plasma concentrations of amino acids (AAs), in particular, branched chain AAs (BCAAs), are often found increased in nonalcoholic fatty liver disease (NAFLD); however, if this is due to increased muscular protein catabolism, obesity, and/or increased insulin resistance (IR) or impaired tissue metabolism is unknown.	Amino Acids	38-41	insulin	Homo sapiens	250-257
28763205-3	2017	Subsequent in situ enantioselective [2,3]-sigmatropic rearrangement catalyzed by the isothiourea benzotetramisole forms syn-alpha-amino acid derivatives with high diastereo- and enantioselectivity.	Amino Acids	124-140	synemin	Homo sapiens	120-123
28782586-2	2017	During past years l-amino acids have been produced from deracemization of dl-solution employing the stereoselective flavoenzyme d-amino acid oxidase.	Amino Acids	18-31	D-amino acid oxidase	Homo sapiens	128-148
29138359-11	2017	The greater satiating efficacy of LEU versus PHE was significantly dissociated from the effects of these AAs on PYY, while the greater satiating potency of TRP versus PHE was significantly dissociated from the effects of these AAs on insulin and glucagon.	Amino Acids	105-108	peptide YY	Homo sapiens	112-115
29084235-6	2017	While human T1R1/T1R3 is activated specifically by L-Glu, the T1R1/T1R3 in other species is a broadly tuned receptor, sensitive to a range of L-amino acids.	Amino Acids	142-155	taste 1 receptor member 1	Homo sapiens	62-71
28840715-5	2017	Structural signals presented on l-amino acid containing cylindrical nanofibers (l-VV) favored the formation of integrin beta1-based focal adhesion complexes, which increased the osteogenic potential of stem cells through the activation of nuclear YAP.	Amino Acids	32-44	integrin subunit beta 1	Homo sapiens	111-125
28592826-2	2017	In this paper, the D-amino acid oxidase can catalytic oxidize L-amino acids by modulating pH of aqueous solution.	Amino Acids	62-75	D-amino acid oxidase	Homo sapiens	19-39
28317771-4	2017	The intermediate structures delivered from the reaction of ortho-quinones with alpha-amino acids were demonstrated by MSn.	Amino Acids	79-96	moesin	Homo sapiens	118-121
28370430-1	2017	5-(1-Hydroxy-pyridin-2(1H)-onyl)-l-alanine (Hop) is a N-hydroxy-1,2-pyridone functionalized alpha-amino acid with the desired metal-chelating properties of DOPA (3,4-dihydroxy phenylalanine) but without its unwanted redox activity.	Amino Acids	92-108	stress induced phosphoprotein 1	Homo sapiens	44-47
28592826-5	2017	The racemization of the L-amino acids was not found by capillary electrophoresis analysis during oxidation, and quantification analysis of L-amino acids before and after catalytic reaction was performed, which confirmed that the modulation of enantioselectivity of DAAO resulted from the oxidation of L-amino acids rather than D-amino acids by changing pH.	Amino Acids	24-37	D-amino acid oxidase	Homo sapiens	265-269
28592826-5	2017	The racemization of the L-amino acids was not found by capillary electrophoresis analysis during oxidation, and quantification analysis of L-amino acids before and after catalytic reaction was performed, which confirmed that the modulation of enantioselectivity of DAAO resulted from the oxidation of L-amino acids rather than D-amino acids by changing pH.	Amino Acids	139-152	D-amino acid oxidase	Homo sapiens	265-269
28592826-5	2017	The racemization of the L-amino acids was not found by capillary electrophoresis analysis during oxidation, and quantification analysis of L-amino acids before and after catalytic reaction was performed, which confirmed that the modulation of enantioselectivity of DAAO resulted from the oxidation of L-amino acids rather than D-amino acids by changing pH.	Amino Acids	139-152	D-amino acid oxidase	Homo sapiens	265-269
28592826-6	2017	A mechanistic model was proposed to explain enhanced activity of DAAO towards L-amino acids under optimal pH condition.	Amino Acids	78-91	D-amino acid oxidase	Homo sapiens	65-69
29086874-1	2017	BACKGROUND: The paper examines Co(II)-amino acid-imidazole systems (where amino acid = L-alpha-amino acid: alanine, asparagine, histidine) which, when in aqueous solutions, activate and reversibly take up dioxygen, while maintaining the structural scheme of the heme group (imidazole as axial ligand and O2 uptake at the sixth, trans position) thus imitating natural respiratory pigments such as myoglobin and hemoglobin.	Amino Acids	87-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	31-37
28363772-5	2017	Using HEK-293 cells recombinantly expressing human GLP-1R, we have previously reported that backbone modification of GLP-1, via replacement of selected alpha-amino acid residues with beta-amino acid residues, generates GLP-1 analogues with distinctive preferences for promoting G protein activation versus beta-arrestin recruitment.	Amino Acids	152-168	glucagon like peptide 1 receptor	Homo sapiens	51-57
28363772-5	2017	Using HEK-293 cells recombinantly expressing human GLP-1R, we have previously reported that backbone modification of GLP-1, via replacement of selected alpha-amino acid residues with beta-amino acid residues, generates GLP-1 analogues with distinctive preferences for promoting G protein activation versus beta-arrestin recruitment.	Amino Acids	152-168	glucagon like peptide 1 receptor	Homo sapiens	51-56
28363772-5	2017	Using HEK-293 cells recombinantly expressing human GLP-1R, we have previously reported that backbone modification of GLP-1, via replacement of selected alpha-amino acid residues with beta-amino acid residues, generates GLP-1 analogues with distinctive preferences for promoting G protein activation versus beta-arrestin recruitment.	Amino Acids	152-168	glucagon like peptide 1 receptor	Homo sapiens	117-122
28615699-3	2017	In the present study, two Arabidopsis PGDH isoforms were inhibited by L-serine but were activated by L-amino acids such as L-homocysteine in vitro.	Amino Acids	101-114	D-3-phosphoglycerate dehydrogenase	Arabidopsis thaliana	38-42
27943578-1	2017	The G protein-coupled receptor GPRC6A (GPCR, Class C, group 6, subtype A) has been proposed to be a sensor for basic L-amino acids that are hypothesized to translate ingestive behaviour to endocrine information.	Amino Acids	117-130	G protein-coupled receptor, family C, group 6, member A	Mus musculus	31-37
27943578-2	2017	However, the contribution of the GPRC6A receptor to L-amino acid-induced glucagon-like peptide 1 (GLP-1) secretion is unclear.	Amino Acids	52-64	G protein-coupled receptor, family C, group 6, member A	Mus musculus	33-39
27943578-2	2017	However, the contribution of the GPRC6A receptor to L-amino acid-induced glucagon-like peptide 1 (GLP-1) secretion is unclear.	Amino Acids	52-64	glucagon	Mus musculus	73-96
27943578-2	2017	However, the contribution of the GPRC6A receptor to L-amino acid-induced glucagon-like peptide 1 (GLP-1) secretion is unclear.	Amino Acids	52-64	glucagon	Mus musculus	98-103
28198184-1	2017	A novel and efficient decarboxylative alkynylation of N-(acetoxy)phthalimides of alpha-amino acids with terminal alkynes has been developed by merging photoredox with copper catalysis at room temperature, and the reaction provided the valuable propargylamines in good to excellent yields with assistance of [Ru(bpy)3]Cl2/CuI and visible light.	Amino Acids	81-98	endogenous retrovirus group W member 5	Homo sapiens	317-320
27533344-8	2016	We show that backbone modification via periodic replacement of alpha-amino acid residues with homologous beta-amino acid residues leads to an alpha/beta-PTH(7-34) peptide that retains the antagonist and inverse agonist activities of the prototype alpha-peptide while exhibiting enhanced stability in the presence of aggressive proteases.	Amino Acids	63-79	parathyroid hormone	Homo sapiens	153-156
28468523-5	2017	Phosphorylation of IGF-I receptor beta-subunits mediated by exogenous IGF-I in HepG2 cells was inhibited by decreased BCAAs, increased NEAAs, and decreased BCAA-to-NEAA ratios, while the total amount of AAs had no effect.	Amino Acids	120-123	insulin like growth factor 1	Homo sapiens	19-24
28468523-5	2017	Phosphorylation of IGF-I receptor beta-subunits mediated by exogenous IGF-I in HepG2 cells was inhibited by decreased BCAAs, increased NEAAs, and decreased BCAA-to-NEAA ratios, while the total amount of AAs had no effect.	Amino Acids	120-123	insulin like growth factor 1	Homo sapiens	70-75
28959860-6	2017	By substituting L-amino acids with D-amino acids, circular constructions and immobilization, cathelicidins" in vitro and in vivo stability could be greatly enhanced, especially their proteinase resistance.	Amino Acids	16-29	endogenous retrovirus group K member 25	Homo sapiens	183-193
27270431-3	2017	However, the critical amino acids (AAs) that are required for CASZ1 interaction with NuRD complex and the regulation of CASZ1 subcellular localization have not been characterized.	Amino Acids	35-38	castor zinc finger 1	Homo sapiens	62-67
27270431-3	2017	However, the critical amino acids (AAs) that are required for CASZ1 interaction with NuRD complex and the regulation of CASZ1 subcellular localization have not been characterized.	Amino Acids	35-38	castor zinc finger 1	Homo sapiens	120-125
28849491-2	2017	Ala, Gln, Gly, Lys, Val and taurine (Tau) are the most abundant free AAs in mammals, and some of these react with hypochlorite (HOCl/OCl-) produced by myeloperoxidase in activated phagocytes to form N-chloroamino acids (NCAA).	Amino Acids	69-72	occludin	Mus musculus	129-132
28849491-2	2017	Ala, Gln, Gly, Lys, Val and taurine (Tau) are the most abundant free AAs in mammals, and some of these react with hypochlorite (HOCl/OCl-) produced by myeloperoxidase in activated phagocytes to form N-chloroamino acids (NCAA).	Amino Acids	69-72	myeloperoxidase	Mus musculus	151-166
27986810-1	2017	GPRC6A is a G protein-coupled receptor activated by l-amino acids, which, based on analyses of knock-out mice, has been suggested to have physiological functions in metabolism and testicular function.	Amino Acids	52-65	G protein-coupled receptor, family C, group 6, member A	Mus musculus	0-6
27626828-4	2016	The discovery of this new class of EAAT1-selective inhibitors not only supplements the currently available pharmacological tools in the EAAT field but also substantiates the notion that EAAT ligands not derived from alpha-amino acids hold considerable potential in terms of subtype-selective modulation of the transporters.	Amino Acids	216-233	solute carrier family 1 member 3	Homo sapiens	35-40
27586187-2	2016	We have previously developed a novel formulation strategy to deliver a hydrophobic Src inhibitor, PP2, involving combinations of one self-assembling peptide (SAP) and one of 4 selected amino acids (AAs).	Amino Acids	198-201	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	83-86
27586187-2	2016	We have previously developed a novel formulation strategy to deliver a hydrophobic Src inhibitor, PP2, involving combinations of one self-assembling peptide (SAP) and one of 4 selected amino acids (AAs).	Amino Acids	198-201	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	98-101
27322739-4	2016	On formation of the 5-methyl-3-arylthiohydantoin ring, bulky o-aryl substituents at N3 were found to suppress the C-5 racemization and in this way enabled the transfer of chirality from the alpha-amino acid to the products.	Amino Acids	190-206	complement C5	Homo sapiens	114-117
27727170-4	2016	In this study, T1R1 and T1R3 subunits were expressed in C2C12 myotubes, and l-AA sensing was accomplished by T1R1/T1R3 to activate mTORC1.	Amino Acids	76-80	taste receptor, type 1, member 1	Mus musculus	15-19
27727170-4	2016	In this study, T1R1 and T1R3 subunits were expressed in C2C12 myotubes, and l-AA sensing was accomplished by T1R1/T1R3 to activate mTORC1.	Amino Acids	76-80	taste receptor, type 1, member 3	Mus musculus	24-28
27727170-4	2016	In this study, T1R1 and T1R3 subunits were expressed in C2C12 myotubes, and l-AA sensing was accomplished by T1R1/T1R3 to activate mTORC1.	Amino Acids	76-80	taste receptor, type 1, member 1	Mus musculus	109-118
27727170-4	2016	In this study, T1R1 and T1R3 subunits were expressed in C2C12 myotubes, and l-AA sensing was accomplished by T1R1/T1R3 to activate mTORC1.	Amino Acids	76-80	CREB regulated transcription coactivator 1	Mus musculus	131-137
27690010-3	2016	As one of the key environmental stimuli, amino acids (AAs), especially leucine, glutamine and arginine, play a crucial role in mTORC1 activation, but where and how AAs are sensed and signal to mTORC1 are not fully understood.	Amino Acids	54-57	CREB regulated transcription coactivator 1	Mus musculus	127-133
27690010-3	2016	As one of the key environmental stimuli, amino acids (AAs), especially leucine, glutamine and arginine, play a crucial role in mTORC1 activation, but where and how AAs are sensed and signal to mTORC1 are not fully understood.	Amino Acids	54-57	CREB regulated transcription coactivator 1	Mus musculus	193-199
27089820-2	2016	Evidence obtained from docking studies suggests that isoindolines derived from alpha-amino acids bind to the LTCC CaV1.2.	Amino Acids	79-96	calcium voltage-gated channel subunit alpha1 C	Homo sapiens	114-120
26661034-1	2016	Asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid (vinyl-ACCA) is in extremely high demand due to the pharmaceutical importance of this tailor-made, sterically constrained alpha-amino acid.	Amino Acids	197-213	G protein-coupled receptor 3	Homo sapiens	82-86
27009828-1	2016	Using the HIF-1alpha transcription factor as a model, this manuscript illustrates how an extended sequence of alpha-amino acids in a polypeptide can be replaced with a non-natural topographical mimic of an alpha-helix comprised from an aromatic oligoamide.	Amino Acids	110-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	10-20
26762192-0	2016	Isoindoline Derivatives of alpha-Amino Acids as Cyclooxygenase 1 and 2 Inhibitors.	Amino Acids	27-44	prostaglandin-endoperoxide synthase 1	Homo sapiens	48-70
26955972-3	2016	In this study, we report a differential and sustained release of an angiogenic factor, fibroblast growth factor-2 (FGF2), and an arteriogenic factor, fibroblast growth factor-9 (FGF9), from alpha-amino acid-derived biodegradable poly(ester amide) (PEA) fibers toward targeting neovessel formation and maturation.	Amino Acids	190-206	fibroblast growth factor 2	Mus musculus	87-113
26955972-3	2016	In this study, we report a differential and sustained release of an angiogenic factor, fibroblast growth factor-2 (FGF2), and an arteriogenic factor, fibroblast growth factor-9 (FGF9), from alpha-amino acid-derived biodegradable poly(ester amide) (PEA) fibers toward targeting neovessel formation and maturation.	Amino Acids	190-206	fibroblast growth factor 2	Mus musculus	115-119
26955972-3	2016	In this study, we report a differential and sustained release of an angiogenic factor, fibroblast growth factor-2 (FGF2), and an arteriogenic factor, fibroblast growth factor-9 (FGF9), from alpha-amino acid-derived biodegradable poly(ester amide) (PEA) fibers toward targeting neovessel formation and maturation.	Amino Acids	190-206	fibroblast growth factor 9	Mus musculus	150-176
26955972-3	2016	In this study, we report a differential and sustained release of an angiogenic factor, fibroblast growth factor-2 (FGF2), and an arteriogenic factor, fibroblast growth factor-9 (FGF9), from alpha-amino acid-derived biodegradable poly(ester amide) (PEA) fibers toward targeting neovessel formation and maturation.	Amino Acids	190-206	fibroblast growth factor 9	Mus musculus	178-182
27092477-0	2016	New Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Inhibitors, Nalidixic Acid Linked to Isatin Schiff Bases via Certain l-Amino Acid Bridges.	Amino Acids	126-138	nitric oxide synthase 2, inducible	Mus musculus	4-35
27092477-0	2016	New Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Inhibitors, Nalidixic Acid Linked to Isatin Schiff Bases via Certain l-Amino Acid Bridges.	Amino Acids	126-138	prostaglandin-endoperoxide synthase 2	Mus musculus	40-56
26762192-1	2016	IC50 values were obtained for two series of isoindolines derived from alpha-amino acids over cyclooxygenase 1 and 2 (COX-1 and COX-2).	Amino Acids	70-87	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	117-122
27383874-2	2016	The human tenomodulin encoding gene is mapped to KH chromosome and encodes a polypeptide consisting of 317 alpha amino acids.	Amino Acids	107-124	tenomodulin	Homo sapiens	10-21
26701297-8	2016	Antagonists for mGluR4 and mGluR1 significantly blocked the responses elicited by IMP and each of the L-amino acids.	Amino Acids	102-115	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	16-22
27092477-7	2016	The higher iNOS inhibition activity of the tested Schiff bases, relative to that of COX-2, seems to be a reflection of the combined suppressive effects exerted by their nalidixic acid, isatins (4a-c), and l-amino acid moieties against iNOS expression.	Amino Acids	205-217	nitric oxide synthase 2, inducible	Mus musculus	11-15
26701297-8	2016	Antagonists for mGluR4 and mGluR1 significantly blocked the responses elicited by IMP and each of the L-amino acids.	Amino Acids	102-115	glutamate receptor, metabotropic 1	Mus musculus	27-33
26701297-9	2016	Collectively, these data provide evidence for the involvement of taste and brain variants of mGluR1 and mGluR4 in L-amino acid and IMP taste responses in mice, and support the concept that multiple receptors contribute to IMP and L-amino acid taste.	Amino Acids	114-126	glutamate receptor, metabotropic 1	Mus musculus	93-99
26701297-9	2016	Collectively, these data provide evidence for the involvement of taste and brain variants of mGluR1 and mGluR4 in L-amino acid and IMP taste responses in mice, and support the concept that multiple receptors contribute to IMP and L-amino acid taste.	Amino Acids	114-126	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	104-110
26701297-9	2016	Collectively, these data provide evidence for the involvement of taste and brain variants of mGluR1 and mGluR4 in L-amino acid and IMP taste responses in mice, and support the concept that multiple receptors contribute to IMP and L-amino acid taste.	Amino Acids	230-242	glutamate receptor, metabotropic 1	Mus musculus	93-99
26759834-6	2016	All of 19 right-handed alpha-amino acids can induce a red-to-blue color change of L-TA-capped AuNP solution, whereas all of the left-handed amino acids (except cysteine) cannot.	Amino Acids	23-40	lymphotoxin alpha	Homo sapiens	82-86
26558536-6	2016	Amino acids (AAs) also regulate IL-17 expression by being the energy source for Th17 cells, and by activating mTORC1 signaling.	Amino Acids	13-16	interleukin 17A	Homo sapiens	32-37
26558536-6	2016	Amino acids (AAs) also regulate IL-17 expression by being the energy source for Th17 cells, and by activating mTORC1 signaling.	Amino Acids	13-16	CREB regulated transcription coactivator 1	Mus musculus	110-116
26785252-0	2016	Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants.	Amino Acids	45-58	G protein-coupled receptor, family C, group 6, member A	Mus musculus	7-13
27022316-1	2016	We systematically investigated the reversibility, time lapse, and oxygenation-deoxygenation properties of 15 natural alpha-amino acid-Co(II) complexes through UV-vis spectrophotometer, polarographic oxygen electrode, and DFT calculations, respectively, to explore the relationship between the coordinating structure and reversible oxygenation of alpha-amino acid-Co(II) complexes.	Amino Acids	117-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
27022316-1	2016	We systematically investigated the reversibility, time lapse, and oxygenation-deoxygenation properties of 15 natural alpha-amino acid-Co(II) complexes through UV-vis spectrophotometer, polarographic oxygen electrode, and DFT calculations, respectively, to explore the relationship between the coordinating structure and reversible oxygenation of alpha-amino acid-Co(II) complexes.	Amino Acids	117-133	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	363-369
27022316-1	2016	We systematically investigated the reversibility, time lapse, and oxygenation-deoxygenation properties of 15 natural alpha-amino acid-Co(II) complexes through UV-vis spectrophotometer, polarographic oxygen electrode, and DFT calculations, respectively, to explore the relationship between the coordinating structure and reversible oxygenation of alpha-amino acid-Co(II) complexes.	Amino Acids	346-362	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-140
26435899-7	2015	We demonstrate an efficient procedure for the preparation of anti and syn beta(2,3)-amino acids with alkyl side chains, from alpha-amino acids in reasonable yields.	Amino Acids	125-142	synemin	Homo sapiens	70-73
26510576-3	2015	We have characterized a short, L-amino acid Abeta-oligomer Interacting Peptide (AIP) that targets a relatively well-defined population of low-n Abeta42 oligomers, rather than simply inhibiting the aggregation of Abeta monomers into oligomers.	Amino Acids	31-43	beta amyloid protein precursor-like	Drosophila melanogaster	44-49
26440882-1	2015	G protein-coupled receptor (GPCR) family C group 6 member A (GPRC6A) is a multiligand GPCR that is activated by cations, L-amino acids, and osteocalcin.	Amino Acids	121-134	G protein-coupled receptor, family C, group 6, member A	Mus musculus	61-67
26599547-2	2015	We have reported that Gpnmb is strongly expressed in the livers of rats fed a choline-deficient, L-amino acid-defined (CDAA) diet.	Amino Acids	97-109	glycoprotein nmb	Rattus norvegicus	22-27
26551350-0	2015	Calcium-sensing receptor (CaSR)-mediated anti-inflammatory effects of L-amino acids in intestinal epithelial cells.	Amino Acids	70-83	calcium sensing receptor	Homo sapiens	0-24
26551350-0	2015	Calcium-sensing receptor (CaSR)-mediated anti-inflammatory effects of L-amino acids in intestinal epithelial cells.	Amino Acids	70-83	calcium sensing receptor	Homo sapiens	26-30
26551350-2	2015	However, no discovery of CaSR-mediated anti-inflammatory effect of l-amino acids (l-AAs) on the gut system has been reported.	Amino Acids	67-80	calcium sensing receptor	Homo sapiens	25-29
26551350-2	2015	However, no discovery of CaSR-mediated anti-inflammatory effect of l-amino acids (l-AAs) on the gut system has been reported.	Amino Acids	82-87	calcium sensing receptor	Homo sapiens	25-29
26551350-10	2015	These results validate a novel mechanism underlying CaSR agonistic l-AAs exerting anti-inflammatory effects on human intestinal epithelia.	Amino Acids	67-72	calcium sensing receptor	Homo sapiens	52-56
26435899-7	2015	We demonstrate an efficient procedure for the preparation of anti and syn beta(2,3)-amino acids with alkyl side chains, from alpha-amino acids in reasonable yields.	Amino Acids	125-142	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	74-82
26308392-3	2015	Here, we show that carbon disulfide (CS2), a component of volcanic emission and sulfide mineral weathering, and a widely used synthetic reagent and solvent, promotes peptide bond formation in modest yields (up to ~20%) from alpha-amino acids under mild aqueous conditions.	Amino Acids	224-241	chorionic somatomammotropin hormone 2	Homo sapiens	37-40
26308392-4	2015	Exposure of a variety of alpha-amino acids to CS2 initially yields aminoacyl dithiocarbamates, which in turn generate reactive 2-thiono-5-oxazolidone intermediates, the thio analogues of N-carboxyanhydrides.	Amino Acids	25-42	chorionic somatomammotropin hormone 2	Homo sapiens	46-49
25796285-15	2015	The proportion of essential AAs (with respect to total AAs) in plasma was greater (P < 0.05) in CTRL (73 +- 2.4%) than that in ARG heifers (65 +- 2.3%).	Amino Acids	28-31	chymotrypsin like	Homo sapiens	99-103
26168033-3	2015	We showed previously that activation of both ERK1/2 and mTORC1 in the MIN6 pancreatic beta-cell-derived line by extracellular amino acids (AAs) is at least in part mediated by the heterodimeric T1R1/T1R3, a G protein-coupled receptor.	Amino Acids	139-142	mitogen-activated protein kinase 3	Mus musculus	45-51
26168033-3	2015	We showed previously that activation of both ERK1/2 and mTORC1 in the MIN6 pancreatic beta-cell-derived line by extracellular amino acids (AAs) is at least in part mediated by the heterodimeric T1R1/T1R3, a G protein-coupled receptor.	Amino Acids	139-142	CREB regulated transcription coactivator 1	Mus musculus	56-62
26168033-3	2015	We showed previously that activation of both ERK1/2 and mTORC1 in the MIN6 pancreatic beta-cell-derived line by extracellular amino acids (AAs) is at least in part mediated by the heterodimeric T1R1/T1R3, a G protein-coupled receptor.	Amino Acids	139-142	taste receptor, type 1, member 1	Mus musculus	194-203
26168033-7	2015	Ca(2+) entry is required for ERK1/2 activation by AAs but is dispensable for AA activation of mTORC1.	Amino Acids	50-53	mitogen-activated protein kinase 3	Mus musculus	29-35
26268630-2	2015	Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver.	Amino Acids	35-38	CREB regulated transcription coactivator 1	Mus musculus	130-136
26268630-2	2015	Levels of circulating amino acids (AAs), which are elevated in obesity, activate the intracellular target of rapamycin complex-1 (mTORC1)/S6kinase (S6K) pathway in the liver.	Amino Acids	35-38	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	148-151
25607821-10	2015	In addition, Sptlc3 mRNA expression in STAM-F mice was higher than that in db/db mice that received HFD and in B6N mice fed a choline-deficient L-amino acid (CDAA)-defined diet.	Amino Acids	144-156	serine palmitoyltransferase, long chain base subunit 3	Mus musculus	13-19
25867051-2	2015	The method utilizes simple alpha-amino acids to deliver syn- and anti- selective isoindolinones with remarkably high enantioselectivity (up to >99% ee) in good to excellent yields and diastereomeric ratios.	Amino Acids	27-44	synemin	Homo sapiens	56-59
25901662-1	2015	We report the crystal structure of a 40 mer mirror-image RNA oligonucleotide completely built from nucleotides of the non-natural L-chirality in complex with the pro-inflammatory chemokine L-CLL2 (monocyte chemoattractant protein-1), a natural protein composed of regular L-amino acids.	Amino Acids	272-285	C-C motif chemokine ligand 2	Homo sapiens	197-231
26112996-5	2015	mTORC1 inhibition not only inhibited the phosphorylation of mTORC1 downstream targets, but also blunted IRS-1 Ser(302) phosphorylation and restored excessive AAs-suppressed Akt phosphorylation.	Amino Acids	158-161	CREB regulated transcription coactivator 1	Mus musculus	0-6
25697780-0	2015	Ligand-enabled beta-C-H arylation of alpha-amino acids using a simple and practical auxiliary.	Amino Acids	37-54	colony stimulating factor 2 receptor subunit beta	Homo sapiens	15-21
26112996-5	2015	mTORC1 inhibition not only inhibited the phosphorylation of mTORC1 downstream targets, but also blunted IRS-1 Ser(302) phosphorylation and restored excessive AAs-suppressed Akt phosphorylation.	Amino Acids	158-161	CREB regulated transcription coactivator 1	Mus musculus	60-66
25230147-3	2014	In this work, we choose a cell compatible molecule, Nap-L-Phe-L-Phe-L-(p)Tyr (LLL-1P), and systematically replace the L-amino acids in this tripeptidic precursor or its hydrogelator by the corresponding D-amino acid(s).	Amino Acids	118-131	catenin beta like 1	Homo sapiens	52-55
25404067-8	2014	This can explain why substitutions of L-amino acids for Gly 6 are known to inactivate GnRH while D-amino acid substitutions enhance its activity.	Amino Acids	38-51	gonadotropin releasing hormone 1	Homo sapiens	86-90
25224490-7	2014	We have shown that FTO expression is regulated by essential amino acids (AAs) and that it couples amino acid levels to mammalian Target of Rapamycin Complex 1 (mTORC1) signalling, through a mechanism dependent on its ability to demethylate.	Amino Acids	73-76	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	19-22
25996030-3	2015	The (R)-STC-based C-CSP can be successfully exploited also at a preparative level for enantioisolations of CNS active amino acids (AAs), with a racemate loadability up to 0.015 g for single injection.	Amino Acids	131-134	stanniocalcin 1	Homo sapiens	8-11
25144906-4	2014	Transitions between C11 and C11/C9 helices are observed upon varying the alpha-amino acid residue.	Amino Acids	73-89	RNA polymerase III subunit K	Homo sapiens	20-23
25253867-2	2014	Evidence supports the involvement of the T1R1 + T1R3 heterodimer, a GPCR broadly tuned to l-amino acids, but variants of two mGluRs expressed in taste buds have also been implicated.	Amino Acids	90-103	taste receptor, type 1, member 1	Mus musculus	41-52
25253867-6	2014	Interestingly, the sensitivity of T1R1 KO mice to another l-amino acid, lysine, was unimpaired, suggesting that some l-amino acids can be detected through T1R1 + T1R3-independent receptors without sensitivity loss.	Amino Acids	117-130	taste receptor, type 1, member 1	Mus musculus	155-166
25144906-4	2014	Transitions between C11 and C11/C9 helices are observed upon varying the alpha-amino acid residue.	Amino Acids	73-89	RNA polymerase III subunit K	Homo sapiens	28-31
24671767-10	2014	We conclude that a tRNA body with high EF-Tu affinity can greatly improve incorporation of unnatural AAs in a potentially generalizable manner.	Amino Acids	101-104	Tu translation elongation factor, mitochondrial	Homo sapiens	39-44
24826842-4	2014	Next, in testing all 20 proteinogenic l-alpha-amino acids, L-tryptophan and l-phenylalanine were found to have EC50 values of 220 and 320 muM, respectively, making them the first putative endogenous agonists for GPR139.	Amino Acids	38-57	latexin	Homo sapiens	138-141
24633359-5	2014	The site-directed mutagenesis analysis revealed that L-theanine binds to L-amino acid binding site in the Venus flytrap domain of T1R1.	Amino Acids	73-85	taste 1 receptor member 1	Homo sapiens	130-134
24382107-1	2014	The extracellular Ca-sensing receptor (CaSR) is a sensor for a number of key nutrients within the body, including Ca ions (Ca2+) and L-amino acids.	Amino Acids	133-146	calcium sensing receptor	Homo sapiens	39-43
24382107-3	2014	This review article examines two emerging roles for the CaSR within the GI tract--as a mediator of kokumi taste modulation in taste cells and as a regulator of dietary hormone release in response to L-amino acids in the intestine.	Amino Acids	199-212	calcium sensing receptor	Homo sapiens	56-60
24382171-7	2014	T1R1-T1R3 combination co-expressed on the apical domain of cholecystokinin (CCK) expressing cells is a luminal sensor for a number of L-amino acids; with amino acid-activation of the receptor eliciting CCK secretion.	Amino Acids	134-147	taste 1 receptor member 1	Homo sapiens	0-4
24382171-7	2014	T1R1-T1R3 combination co-expressed on the apical domain of cholecystokinin (CCK) expressing cells is a luminal sensor for a number of L-amino acids; with amino acid-activation of the receptor eliciting CCK secretion.	Amino Acids	134-147	taste 1 receptor member 3	Homo sapiens	5-9
24382171-7	2014	T1R1-T1R3 combination co-expressed on the apical domain of cholecystokinin (CCK) expressing cells is a luminal sensor for a number of L-amino acids; with amino acid-activation of the receptor eliciting CCK secretion.	Amino Acids	134-147	cholecystokinin	Homo sapiens	59-74
24382171-7	2014	T1R1-T1R3 combination co-expressed on the apical domain of cholecystokinin (CCK) expressing cells is a luminal sensor for a number of L-amino acids; with amino acid-activation of the receptor eliciting CCK secretion.	Amino Acids	134-147	cholecystokinin	Homo sapiens	76-79
24382171-8	2014	This article focuses on the role of the gut-expressed T1R1, T1R2 and T1R3 in intestinal sweet and L-amino acid sensing.	Amino Acids	98-110	taste 1 receptor member 1	Homo sapiens	54-58
24382171-8	2014	This article focuses on the role of the gut-expressed T1R1, T1R2 and T1R3 in intestinal sweet and L-amino acid sensing.	Amino Acids	98-110	taste 1 receptor member 3	Homo sapiens	69-73
25228803-2	2014	A 1,3-cycloaddition was developed using an azomethine ylide, generated by reacting paraformaldehyde and a side-chain-Boc (tert-Butyloxycarbonyl)-protected, lysine-derived alpha-amino acid, H-Lys(Boc)-OH, with purified SWCNT or C60.	Amino Acids	171-187	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	Mus musculus	117-120
25228803-2	2014	A 1,3-cycloaddition was developed using an azomethine ylide, generated by reacting paraformaldehyde and a side-chain-Boc (tert-Butyloxycarbonyl)-protected, lysine-derived alpha-amino acid, H-Lys(Boc)-OH, with purified SWCNT or C60.	Amino Acids	171-187	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	Mus musculus	195-198
24382107-1	2014	The extracellular Ca-sensing receptor (CaSR) is a sensor for a number of key nutrients within the body, including Ca ions (Ca2+) and L-amino acids.	Amino Acids	133-146	calcium sensing receptor	Homo sapiens	18-37
23496213-2	2013	The method utilizes the RuHCl(CO)(PPh3)3/iPrOH catalytic system under an Ar atmosphere and provides alpha-branched allylic alpha-amino acid derivatives.	Amino Acids	123-139	caveolin 1	Homo sapiens	34-38
24411479-6	2014	The C-terminal Gly and a l-amino acid analogue at the Cys binding site were necessary for inhibition, suggesting that human GGT was highly selective for glutathione (gamma-Glu-l-Cys-Gly), whereas E. coli GGT are not selective for glutathione, but still retained the dipeptide (l-AA-Gly) binding site.	Amino Acids	25-37	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	124-127
24411479-6	2014	The C-terminal Gly and a l-amino acid analogue at the Cys binding site were necessary for inhibition, suggesting that human GGT was highly selective for glutathione (gamma-Glu-l-Cys-Gly), whereas E. coli GGT are not selective for glutathione, but still retained the dipeptide (l-AA-Gly) binding site.	Amino Acids	25-37	gamma-glutamyltransferase 2, pseudogene	Homo sapiens	204-207
24758431-2	2014	In the field of peptidomimetics, beta-peptides incorporating beta2- and beta3-amino acids (the higher homologs of natural alpha-amino acids) provide a powerful method for the synthesis of peptidomimetics with particular secondary structures.	Amino Acids	122-139	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	61-77
24604724-4	2014	gNanog ORF is 903 bp long which codes for Nanog protein of size 300 amino acids (aas).	Amino Acids	81-84	homeobox protein NANOG	Cricetulus griseus	1-6
24214976-2	2013	T1R1/T1R3 exhibits species-dependent differences in ligand specificity; human T1R1/T1R3 specifically responds to L-Glu, whereas mouse T1R1/T1R3 responds more strongly to other L-amino acids than to L-Glu.	Amino Acids	176-189	taste 1 receptor member 1	Homo sapiens	0-4
24214976-2	2013	T1R1/T1R3 exhibits species-dependent differences in ligand specificity; human T1R1/T1R3 specifically responds to L-Glu, whereas mouse T1R1/T1R3 responds more strongly to other L-amino acids than to L-Glu.	Amino Acids	176-189	taste 1 receptor member 3	Homo sapiens	5-9
24214976-2	2013	T1R1/T1R3 exhibits species-dependent differences in ligand specificity; human T1R1/T1R3 specifically responds to L-Glu, whereas mouse T1R1/T1R3 responds more strongly to other L-amino acids than to L-Glu.	Amino Acids	176-189	taste receptor, type 1, member 1	Mus musculus	0-9
24228513-1	2013	Integrated stress response (ISR) is a high conserved cell adaptive response, which is induced by oxidative stress, deprivation of acid aminos, and endoplasmic reticulum (ER) stress through eukaryotic translation initiator factor 2alpha (eIF2alpha) pathway.	Amino Acids	130-141	eukaryotic translation initiation factor 2A	Homo sapiens	237-246
23914308-1	2013	This review is focused on three types of enzymes decarboxylating very different substrates: (1) Thiamin diphosphate (ThDP)-dependent enzymes reacting with 2-oxo acids; (2) Pyridoxal phosphate (PLP)-dependent enzymes reacting with alpha-amino acids; and (3) An enzyme with no known co-factors, orotidine 5"-monophosphate decarboxylase (OMPDC).	Amino Acids	230-247	pyridoxal phosphatase	Homo sapiens	193-196
23267858-2	2013	While extracellular calcium (Ca(2+)o) is considered the primary physiological ligand, the CaSR is activated physiologically by a plethora of molecules including polyamines and l-amino acids.	Amino Acids	176-189	calcium sensing receptor	Homo sapiens	90-94
23827208-7	2013	Separate expression of the two chains, followed by assembly in a refolding buffer, yielded an Fab that was demonstrated to bind to l-amino acids but not to recognize the corresponding d-enantiomers.	Amino Acids	131-144	FA complementation group B	Homo sapiens	94-97
22497557-0	2012	C2-symmetric recyclable organocatalyst for enantioselective Strecker reaction for the synthesis of alpha-amino acid and chiral diamine--an intermediate for APN inhibitor.	Amino Acids	99-115	alanyl aminopeptidase, membrane	Homo sapiens	156-159
23203156-3	2013	In the lingual epithelium, the sensing of a broad spectrum of L-amino acids is accomplished by the heteromeric amino acid (umami) taste receptor (T1R1-T1R3).	Amino Acids	62-75	taste receptor, type 1, member 1	Mus musculus	146-150
23203156-3	2013	In the lingual epithelium, the sensing of a broad spectrum of L-amino acids is accomplished by the heteromeric amino acid (umami) taste receptor (T1R1-T1R3).	Amino Acids	62-75	taste receptor, type 1, member 3	Mus musculus	151-155
23203156-7	2013	We show here that, in response to L-amino acids (Phe, Leu, Glu, and Trp), but not D-amino acids, STC-1 enteroendocrine cells and mouse proximal small intestinal tissue explants secrete CCK and that IMP enhances Phe-, Leu-, and Glu-induced, but not Trp-induced, CCK secretion.	Amino Acids	34-47	cholecystokinin	Mus musculus	185-188
23161488-3	2013	First, a microchip CE (MCE)-LIF was established for the separation of L-amino acids (L-Gln and L-glutamic acid) and studying the hydrolysis of L-Gln by using L-Asnase enzyme reactor.	Amino Acids	70-83	LIF interleukin 6 family cytokine	Homo sapiens	28-31
23413682-4	2012	It is proposed that the unique properties of LAAO) are based on their catalytic reaction, which causes the decrease of L-amino acid levels, including the essential amino acids and formation of hydrogen peroxide.	Amino Acids	119-131	interleukin 4 induced 1	Mus musculus	45-49
22714012-1	2013	GPRC6A is a seven-transmembrane receptor activated by a wide range of L-alpha-amino acids, most potently by L-arginine and other basic amino acids.	Amino Acids	70-89	G protein-coupled receptor, family C, group 6, member A	Mus musculus	0-6
23355881-1	2013	L-amino acid oxidases (LAAO) are flavoproteins that catalyze the oxidative deamination of L-amino acids to a keto-acid along with the production of H2O2 and ammonia.	Amino Acids	90-103	interleukin 4 induced 1	Homo sapiens	0-21
23355881-1	2013	L-amino acid oxidases (LAAO) are flavoproteins that catalyze the oxidative deamination of L-amino acids to a keto-acid along with the production of H2O2 and ammonia.	Amino Acids	90-103	interleukin 4 induced 1	Homo sapiens	23-27
22687819-4	2012	Placental insulin/IGF-I signaling and fetal levels of oxygen, glucose and amino acids (AAs) are altered in pregnancy complications such as intrauterine growth restriction, and all these factors are well-established upstream regulators of mTORC1.	Amino Acids	87-90	CREB regulated transcription coactivator 1	Mus musculus	238-244
22687819-7	2012	Recently, significant progress has been made in identifying the molecular mechanisms by which mTORC1 senses AAs, a process requiring shuttling of mTOR to late endosomal and lysosomal compartments (LELs).	Amino Acids	108-111	CREB regulated transcription coactivator 1	Mus musculus	94-100
22687819-7	2012	Recently, significant progress has been made in identifying the molecular mechanisms by which mTORC1 senses AAs, a process requiring shuttling of mTOR to late endosomal and lysosomal compartments (LELs).	Amino Acids	108-111	mechanistic target of rapamycin kinase	Homo sapiens	94-98
22374969-4	2012	GPRC6A is an amino acid-sensing G protein-coupled receptor highly expressed in beta-cells and is activated by recombinant Ocn in vitro and in vivo but that is widely expressed in tissues other than the pancreas and is capable of sensing multiple structurally unrelated ligands, including l-amino acids, cations, and anabolic steroids in addition to Ocn.	Amino Acids	288-301	G protein-coupled receptor, family C, group 6, member A	Mus musculus	0-6
22374969-4	2012	GPRC6A is an amino acid-sensing G protein-coupled receptor highly expressed in beta-cells and is activated by recombinant Ocn in vitro and in vivo but that is widely expressed in tissues other than the pancreas and is capable of sensing multiple structurally unrelated ligands, including l-amino acids, cations, and anabolic steroids in addition to Ocn.	Amino Acids	288-301	bone gamma-carboxyglutamate protein 2	Mus musculus	122-125
22093698-6	2012	Recombinant human GTK (rhGTK) has a relatively open catalytic active site, and we report here that this enzyme, like the rat and bovine enzymes, can also utilize sulfur-containing l-amino acids, including l-methionine, l-cystine, and l-cystathionine as substrates.	Amino Acids	180-193	kynurenine aminotransferase 1	Homo sapiens	18-21
22250978-3	2012	For most proteinogenic and all studied unproteinogenic alpha-amino acids, very good results were obtained using a substoichiometric amount of SiO(2)-Pip as the base.	Amino Acids	55-72	prolactin induced protein	Homo sapiens	149-152
22257032-7	2012	Rat GGT (and presumably HuGGT) has strict stereospecificity for L-amino acid acceptor substrates, while CapD can utilize both L- and D-acceptor substrates comparably.	Amino Acids	64-76	gamma-glutamyltransferase 1	Rattus norvegicus	4-7
22108047-6	2012	Of the downregulated AFP fragments, 72.7% (8/11) were confined to the AFP N-terminus (amino acids [aas] 25-440) and 77.1% (27/35) of upregulated AFP fragments were confined to the AFP C-terminus (aas 340-596).	Amino Acids	99-102	alpha-fetoprotein	Rattus norvegicus	21-24
22300073-10	2012	The metabotropic glutamate receptor (mGluR), calcium-sensing receptor (CaR), and GPCR family C, group 6, subtype A receptor (GPRC6A) mediate L-amino acid-sensing.	Amino Acids	141-153	G protein-coupled receptor class C group 6 member A	Homo sapiens	125-131
22448252-4	2012	We find that the first 10 amino acids (AAs) of NANOS2 are required for this binding.	Amino Acids	39-42	nanos C2HC-type zinc finger 2	Mus musculus	47-53
23300778-3	2012	Emb-LPD induced changes in maternal serum metabolites at the time of blastocyst formation (E3.5), notably reduced insulin and increased glucose, together with reduced levels of free amino acids (AAs) including branched chain AAs leucine, isoleucine and valine.	Amino Acids	195-198	embigin	Mus musculus	0-3
23300778-3	2012	Emb-LPD induced changes in maternal serum metabolites at the time of blastocyst formation (E3.5), notably reduced insulin and increased glucose, together with reduced levels of free amino acids (AAs) including branched chain AAs leucine, isoleucine and valine.	Amino Acids	195-198	acyl-CoA synthetase bubblegum family member 1	Mus musculus	4-7
23300778-3	2012	Emb-LPD induced changes in maternal serum metabolites at the time of blastocyst formation (E3.5), notably reduced insulin and increased glucose, together with reduced levels of free amino acids (AAs) including branched chain AAs leucine, isoleucine and valine.	Amino Acids	225-228	embigin	Mus musculus	0-3
23300778-3	2012	Emb-LPD induced changes in maternal serum metabolites at the time of blastocyst formation (E3.5), notably reduced insulin and increased glucose, together with reduced levels of free amino acids (AAs) including branched chain AAs leucine, isoleucine and valine.	Amino Acids	225-228	acyl-CoA synthetase bubblegum family member 1	Mus musculus	4-7
22574197-1	2012	Mammalian Target of Rapamycin Complex 1 (mTORC1) is activated by growth factor-regulated phosphoinositide 3-kinase (PI3K)/Akt/Rheb signalling and extracellular amino acids (AAs) to promote growth and proliferation.	Amino Acids	173-176	CREB regulated transcription coactivator 1	Mus musculus	41-47
22574197-1	2012	Mammalian Target of Rapamycin Complex 1 (mTORC1) is activated by growth factor-regulated phosphoinositide 3-kinase (PI3K)/Akt/Rheb signalling and extracellular amino acids (AAs) to promote growth and proliferation.	Amino Acids	173-176	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	89-114
21376068-4	2011	T1R3 also combines with T1R1 to form a heterodimer that binds with l-amino acids.	Amino Acids	67-80	taste receptor, type 1, member 3	Mus musculus	0-4
21376068-4	2011	T1R3 also combines with T1R1 to form a heterodimer that binds with l-amino acids.	Amino Acids	67-80	taste receptor, type 1, member 1	Mus musculus	24-28
21290119-2	2011	Recently, we detected the frequent mutations of LPA receptor-1 (LPA1) gene in rat hepatocellular carcinomas (HCCs) induced by a choline-deficient L-amino acid-defined (CDAA) diet.	Amino Acids	146-158	lysophosphatidic acid receptor 1	Rattus norvegicus	48-62
21983823-1	2011	Chiral micellar electrokinetic chromatography with laser-induced fluorescence detection (chiral-MEKC-LIF) was used to investigate D- and L-amino acid contents in cerebrospinal fluid (CSF) samples related to different Alzheimer disease (AD) stages.	Amino Acids	137-149	LIF interleukin 6 family cytokine	Homo sapiens	101-104
21804067-1	2011	The apoA-I mimetic peptide L-4F [(Ac-D-W-F-K-A-F-Y-D-K-V-A-E-K-F-K-E-A-F-NH2) synthesized from all L-amino acids] has shown potential for the treatment of a variety of diseases.	Amino Acids	99-112	apolipoprotein A1	Homo sapiens	4-10
21616512-2	2011	The purpose of this study was to examine the effect of high-dose insulin therapy on the plasma concentrations of amino acids (AAs) in patients undergoing coronary artery bypass grafting surgery.	Amino Acids	126-129	insulin	Homo sapiens	65-72
21290119-2	2011	Recently, we detected the frequent mutations of LPA receptor-1 (LPA1) gene in rat hepatocellular carcinomas (HCCs) induced by a choline-deficient L-amino acid-defined (CDAA) diet.	Amino Acids	146-158	lysophosphatidic acid receptor 1	Rattus norvegicus	64-68
20880398-1	2010	BACKGROUND AND PURPOSE The intestinal proton-coupled amino acid transporter, SLC36A1, transports zwitterionic alpha-amino acids and drugs such as vigabatrin, gaboxadol and delta-aminolevulinic acid.	Amino Acids	110-127	solute carrier family 36 member 1	Homo sapiens	77-84
21378189-7	2011	The dadA promoter was induced by several L-amino acids, most strongly by Ala, and only by D-Ala among all tested D-amino acids.	Amino Acids	41-54	D-amino acid dehydrogenase small subunit	Pseudomonas aeruginosa PAO1	4-8
21252045-1	2011	The extracellular calcium-sensing receptor (CaSR) has recently been recognized as an L-amino acid sensor and has been implicated in mediating cholecystokinin (CCK) secretion in response to aromatic amino acids.	Amino Acids	85-97	calcium-sensing receptor	Mus musculus	4-42
21252045-1	2011	The extracellular calcium-sensing receptor (CaSR) has recently been recognized as an L-amino acid sensor and has been implicated in mediating cholecystokinin (CCK) secretion in response to aromatic amino acids.	Amino Acids	85-97	calcium-sensing receptor	Mus musculus	44-48
21252045-1	2011	The extracellular calcium-sensing receptor (CaSR) has recently been recognized as an L-amino acid sensor and has been implicated in mediating cholecystokinin (CCK) secretion in response to aromatic amino acids.	Amino Acids	85-97	cholecystokinin	Mus musculus	159-162
20872892-1	2010	Chiral discrimination of seven enantiomeric pairs of beta-3-homo-amino acids was studied by using the kinetic method and trimeric metal-bound complexes, with natural and unnatural alpha-amino acids as chiral reference compounds and divalent metal ions (Cu(2+) and Ni(2+) ) as the center ions.	Amino Acids	180-197	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	53-59
21730182-5	2011	Transgenic expression of natural, L-amino acid ABP1 analogues reduced CUG-induced toxicity in fly eyes and muscles.	Amino Acids	34-46	Actin binding protein 1	Drosophila melanogaster	47-51
21539897-6	2011	Bl-LAAO catalyzes oxidative deamination of l-amino acids with the generation of H2O2.	Amino Acids	43-56	interleukin 4 induced 1	Homo sapiens	3-7
20718422-6	2010	Previously we described a foldamer (designated 1 here) that was generated from GCN4-pLI by replacing every third alpha-amino acid residue with the homologous beta(3)-amino acid residue; this alphaalphabeta oligomer retains the side chain sequence of the original alpha-peptide, but the backbone contains 11 additional CH(2) units, which are evenly distributed (Horne et al.	Amino Acids	113-129	amino acid starvation-responsive transcription factor GCN4	Saccharomyces cerevisiae S288C	79-83
20441938-4	2010	Furthermore, the expanding enzymatic use of L-amino acid oxidase to incubate with different L-amino acids has allowed understanding of the substrate"s specificity.	Amino Acids	92-105	interleukin 4 induced 1	Homo sapiens	44-64
20534849-3	2010	Here we show that Trpm5(-/-) mice, which lack the cellular mechanisms required for sweet and several forms of l-amino acid taste transduction, develop a robust preference for d-glucose compared with isocaloric l-serine independently of the perception of sweetness.	Amino Acids	110-122	transient receptor potential cation channel, subfamily M, member 5	Mus musculus	18-23
26224905-1	2010	MP2 modelling and topological QTAIM analysis of chiral metallocomplex synthons of alpha-amino acids used for the preparation of radiopharmaceuticals for positron emission tomography.	Amino Acids	82-99	tryptase pseudogene 1	Homo sapiens	0-3
20047345-2	2010	As the hydrolysis of bovine serum albumin (BSA) with the aid of trypsin produces alpha-amino acids, the complex of 1/Cu(2+)/BSA could act as a label-free, sensitive, selective sensor toward trypsin.	Amino Acids	81-98	albumin	Homo sapiens	28-41
19214702-1	2010	The synthesis of new substituted prolines carrying at C-4 a second alpha-amino acid residue is reported.	Amino Acids	67-83	complement C4A (Rodgers blood group)	Homo sapiens	54-57
20582794-4	2010	Glucose dehydrogenase was used for the regeneration of NADH and (15)NH(4)Cl as isotopically labelled material at 99 at.% (15)N. All reactions are inexpensive and easy to perform on a synthetically useful scale (1-10g) giving high yields of l-amino acids.	Amino Acids	240-253	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	0-21
20216569-2	2010	It has been shown that GH release can be promoted by administration of various amino acids (AAs), such as arginine and lysine, that are present in soy protein.	Amino Acids	92-95	growth hormone 1	Homo sapiens	23-25
19957998-6	2010	All the l-amino acid 3-HPG esters were effectively activated in HeLa and Caco-2 cell homogenates and were found to be good substrates of hVACVase (k(cat)/K(m) in mM(-1) x s(-1): Val-3-HPG, 3370; Ile-3-HPG, 1580; Phe-3-HPG, 1660).	Amino Acids	8-20	biphenyl hydrolase like	Homo sapiens	137-145
19969456-0	2010	Structure-guided design of alpha-amino acid-derived Pin1 inhibitors.	Amino Acids	27-43	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	52-56
19587847-9	2009	Furthermore, exposing mouse hypothalamic cells to a low-glucose medium, while maintaining normal l-amino acid concentrations, specifically resulted in higher expression levels of the sweet-associated gene Tas1r2.	Amino Acids	97-109	taste receptor, type 1, member 2	Mus musculus	205-211
19631258-7	2009	These findings suggest that multiple receptors are involved in amino acid taste and that taste-mGluR4 receptors contribute to the taste of MSG and at least some l-amino acids.	Amino Acids	161-174	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	95-101
19640775-1	2009	Studies of nonenzymatic electrophilic catalysis of carbon deprotonation of glycine show that pyridoxal 5"-phosphate (PLP) strongly enhances the carbon acidity of alpha-amino acids, but that this is not the overriding mechanistic imperative for cofactor catalysis.	Amino Acids	162-179	pyridoxal phosphatase	Homo sapiens	117-120
19567535-2	2009	OBJECTIVE: Because the Ca(2+)(o) sensitivity of the CaR is positively modulated by L-amino acids, we decided to investigate whether the impaired feedback of PTH secretion in adenomatous parathyroid cells might arise from decreased sensitivity to L-amino acids.	Amino Acids	83-96	calcium sensing receptor	Homo sapiens	52-55
19652891-6	2009	Furthermore, ADAMTS13 mRNA expression was increased with enhanced mRNA expression in smooth muscle alpha-actin in the livers of rats fed a choline-deficient L-amino acid-defined-diet for 16 weeks, in which increased plasma ADAMTS13 activity was determined.	Amino Acids	157-169	ADAM metallopeptidase with thrombospondin type 1 motif, 13	Rattus norvegicus	13-21
19652891-6	2009	Furthermore, ADAMTS13 mRNA expression was increased with enhanced mRNA expression in smooth muscle alpha-actin in the livers of rats fed a choline-deficient L-amino acid-defined-diet for 16 weeks, in which increased plasma ADAMTS13 activity was determined.	Amino Acids	157-169	actin alpha 2, smooth muscle	Rattus norvegicus	85-110
19686105-11	2009	Further, these studies suggest that afferent signaling from T1R1+T1R3 and taste-mGluR4 likely combine to generate the taste sensations associated with other L-amino acids.	Amino Acids	157-170	taste receptor, type 1, member 1	Mus musculus	60-69
19686105-11	2009	Further, these studies suggest that afferent signaling from T1R1+T1R3 and taste-mGluR4 likely combine to generate the taste sensations associated with other L-amino acids.	Amino Acids	157-170	glutamate receptor, ionotropic, AMPA4 (alpha 4)	Mus musculus	80-86
19567535-9	2009	CONCLUSIONS: Impaired L-amino acid sensing by calcium-sensing receptors in adenomatous parathyroid cells contributes to the loss of feedback control of PTH secretion in primary hyperparathyroidism.	Amino Acids	22-34	parathyroid hormone	Homo sapiens	152-155
19416517-4	2009	FINDINGS: In the current study, we found that losartan, a clinically used angiotensin-II type 1 receptor blocker, significantly attenuated a choline-deficient L-amino acid-defined (CDAA) diet-induced steatohepatitis in obese diabetic- and insulin resistance-associated Otsuka Long-Evans Tokushima Fatty (OLETF) rats.	Amino Acids	159-171	angiotensin II receptor, type 1b	Rattus norvegicus	74-104
20084184-6	2009	CMAP corrections to the L-amino acids help reduce the excessive translocation barrier.	Amino Acids	24-37	cystatin F	Homo sapiens	0-4
18698640-2	2009	It is shown in this work that the chiral-induced equilibrium shift of [Tb(CDA)3](6-) by L-amino acids (i.e. L-proline or L-arginine) was largely influenced by the hydrogen-bonding networks formed between the ligand interface of racemic [Tb(CDA)3](6-) and these added chiral agents.	Amino Acids	88-101	CDAN3	Homo sapiens	74-79
18698640-2	2009	It is shown in this work that the chiral-induced equilibrium shift of [Tb(CDA)3](6-) by L-amino acids (i.e. L-proline or L-arginine) was largely influenced by the hydrogen-bonding networks formed between the ligand interface of racemic [Tb(CDA)3](6-) and these added chiral agents.	Amino Acids	88-101	CDAN3	Homo sapiens	240-245
18698640-4	2009	This result suggested that the hydrogen-bonding networks serve as the basis for further noncovalent discriminatory interactions between racemic [Tb(CDA)3](6-) and added L-amino acids.	Amino Acids	169-182	CDAN3	Homo sapiens	148-153
19569527-1	2009	Nonapeptide H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2 corresponding to a modified sequence of autoinhibitory region of myosin light chain kinase (MLCK) was synthesized from L-amino acids and from D-amino acids.	Amino Acids	173-186	myosin light chain kinase	Homo sapiens	119-144
19569527-1	2009	Nonapeptide H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2 corresponding to a modified sequence of autoinhibitory region of myosin light chain kinase (MLCK) was synthesized from L-amino acids and from D-amino acids.	Amino Acids	173-186	myosin light chain kinase	Homo sapiens	146-150
19191236-11	2009	Finally, post-cleavage oxidation gave access to the Fmoc/Boc-protected alpha-amino acid as well as the corresponding aldehyde.	Amino Acids	71-87	BOC cell adhesion associated, oncogene regulated	Homo sapiens	57-60
19240036-1	2009	System A transporters SNAT1 and SNAT2 mediate uptake of neutral alpha-amino acids (e.g. glutamine, alanine, and proline) and are expressed in central neurons.	Amino Acids	64-81	solute carrier family 38 member 1	Homo sapiens	22-27
19240036-1	2009	System A transporters SNAT1 and SNAT2 mediate uptake of neutral alpha-amino acids (e.g. glutamine, alanine, and proline) and are expressed in central neurons.	Amino Acids	64-81	solute carrier family 38 member 2	Homo sapiens	32-37
19416166-4	2009	For optimal signaling the RLF requires five L-alpha-amino acids preceding cysteine A10, whereas the B chain requires only three.	Amino Acids	44-63	RLF zinc finger	Homo sapiens	26-29
19103720-1	2009	GPRC6A is a seven-transmembrane receptor mediating signaling by a wide range of L-alpha-amino acids, a signaling augmented by the divalent cations Ca(2)(+) and Mg(2)(+).	Amino Acids	80-99	G protein-coupled receptor, family C, group 6, member A	Mus musculus	0-6
19130438-0	2009	The copper-catalyzed decarboxylative coupling of the sp3-hybridized carbon atoms of alpha-amino acids.	Amino Acids	84-101	Sp3 transcription factor	Homo sapiens	53-56
18514621-4	2008	We also report preliminary experimental data that suggest the existence of intracellular alternatives to insulin metabolic pathways stimulated by nutrients such as amino acids (AAs).	Amino Acids	177-180	insulin	Homo sapiens	105-112
18821748-0	2008	Synthesis and utilization of chiral alpha-methylated alpha-amino acids with a carboxyalkyl side chain in the design of novel Grb2-SH2 peptide inhibitors free of phosphotyrosine.	Amino Acids	53-70	growth factor receptor bound protein 2	Homo sapiens	125-129
18718864-5	2008	DmNAT1 is strongly transcribed in the absorptive and secretory regions of the larval alimentary canal and larval brain, revealing its roles in the primary absorption and redistribution of large neutral l-amino acids as well as corresponding d-isomers.	Amino Acids	202-215	Nutrient Amino Acid Transporter 1	Drosophila melanogaster	0-6
18423979-3	2008	Sea bass gdf9 and bmp15 cDNAs were 2200 and 2049 bp long, coding for 438 and 459 amino acids (aas), respectively, and were most similar to zebrafish gdf9 and bmp15 (64.4 and 56.1%, respectively).	Amino Acids	94-97	dynein axonemal assembly factor 11	Danio rerio	0-3
18423979-3	2008	Sea bass gdf9 and bmp15 cDNAs were 2200 and 2049 bp long, coding for 438 and 459 amino acids (aas), respectively, and were most similar to zebrafish gdf9 and bmp15 (64.4 and 56.1%, respectively).	Amino Acids	94-97	growth differentiation factor 9	Danio rerio	9-13
18423979-3	2008	Sea bass gdf9 and bmp15 cDNAs were 2200 and 2049 bp long, coding for 438 and 459 amino acids (aas), respectively, and were most similar to zebrafish gdf9 and bmp15 (64.4 and 56.1%, respectively).	Amino Acids	94-97	bone morphogenetic protein 15	Danio rerio	18-23
18514621-5	2008	Indeed, we found that oral supplements with AAs stimulated both glucose transporter-4 and protein synthesis through independent insulin signals in rat hearts.	Amino Acids	44-47	insulin	Homo sapiens	128-135
18460336-4	2008	Here we show that AAs induce a rise in intracellular Ca(2+) ([Ca(2+)](i)), which triggers mTOR Complex 1 and hVps34 activation.	Amino Acids	18-21	mechanistic target of rapamycin kinase	Homo sapiens	90-94
18460336-4	2008	Here we show that AAs induce a rise in intracellular Ca(2+) ([Ca(2+)](i)), which triggers mTOR Complex 1 and hVps34 activation.	Amino Acids	18-21	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	109-115
18057744-1	2007	The enantioselectivity of the intramolecular asymmetric aldol reaction of 1,3-cycloheptanedione bearing a C-2 methyl substituent, mediated by a series of combinations of L-amino acid and Bronsted acid, was examined in detail.	Amino Acids	170-182	complement C2	Homo sapiens	106-109
18404750-0	2008	Catalytic synthesis of beta3-amino acid derivatives from alpha-amino acids.	Amino Acids	57-74	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	23-28
18776430-1	2008	The aminoacylation of tRNA, a process in which amino acids first encounter RNA, may be closely related to the origin of L-amino acid homochirality in biological systems.	Amino Acids	120-132	mitochondrially encoded tRNA glycine	Homo sapiens	22-26
18776430-2	2008	A clear preference for L-amino acids as opposed to D-amino acids was noted in the efficient nonenzymatic aminoacylation of an RNA minihelix (progenitor of the modern tRNA) by an aminoacyl phosphate oligonucleotide.	Amino Acids	23-36	mitochondrially encoded tRNA glycine	Homo sapiens	166-170
18776430-5	2008	These results clearly suggest that tRNA aminoacylation may have been a critical step in determining L-amino acid homochirality.	Amino Acids	100-112	mitochondrially encoded tRNA glycine	Homo sapiens	35-39