PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
1894644-0	1991	Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells.	Chondroitin Sulfates	122-141	transforming growth factor beta 1	Homo sapiens	46-79
1907203-0	1991	Molecular parameters that control the association of low density lipoprotein apo B-100 with chondroitin sulphate.	Chondroitin Sulfates	92-112	apolipoprotein B	Homo sapiens	77-86
1907203-4	1991	Results from earlier studies suggest that surface located segments of apo B-100 are responsible for the interaction of LDL with heparin and chondroitin sulphate-rich arterial proteoglycans.	Chondroitin Sulfates	140-160	apolipoprotein B	Homo sapiens	70-79
2071579-5	1991	In addition to heparin, SAP bound to heparan sulfate and chondroitin sulfate.	Chondroitin Sulfates	57-76	amyloid P component, serum	Homo sapiens	24-27
1906475-5	1991	Based on the deduced amino acid sequence and immunochemical analysis of proteolytic fragments of NG2, the extracellular region can be divided into three domains: an amino terminal cysteine-containing domain which is stabilized by intrachain disulfide bonds, a serine-glycine-containing domain to which chondroitin sulfate chains are attached, and another cysteine-containing domain.	Chondroitin Sulfates	302-321	chondroitin sulfate proteoglycan 4	Rattus norvegicus	97-100
1939375-1	1991	In previous studies we have shown that transferrin (Tf) specifically stimulates dermatan- and chondroitin-sulphate proteoglycan accumulation around lung cells, and in the extracellular matrix of lung tissue, in vitro.	Chondroitin Sulfates	94-114	transferrin	Rattus norvegicus	39-50
1939375-1	1991	In previous studies we have shown that transferrin (Tf) specifically stimulates dermatan- and chondroitin-sulphate proteoglycan accumulation around lung cells, and in the extracellular matrix of lung tissue, in vitro.	Chondroitin Sulfates	94-114	transferrin	Rattus norvegicus	52-54
1647411-4	1991	The IgM kappa M-protein reacts with chondroitin sulfate C and binds to a broad nerve protein band with a mobility of between 170 and 118 kDa.	Chondroitin Sulfates	36-57	myomesin 2	Homo sapiens	14-23
1794040-1	1991	In this report we describe a system capable of resolving all of the known unsaturated disaccharides derived from the chondroitin sulphates, dermatan sulphate and hyaluronic acid by chondroitinase digestion.	Chondroitin Sulfates	117-138	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	181-195
1905276-5	1991	By contrast, media from ASB-deficient cultures initiated from the inferior region of the eye contained much higher levels of radiolabeled dermatan/chondroitin sulfate than ASB-deficient cultures from the superior region or normal cultures.	Chondroitin Sulfates	147-166	arylsulfatase B	Felis catus	24-27
2029496-5	1991	We confirmed the work of others that it is the apolipoprotein B component and, at least in part, a heparin-binding domain of LDL that are responsible for binding chondroitin sulfate/dermatan sulfate proteoglycans.	Chondroitin Sulfates	162-181	apolipoprotein B	Homo sapiens	47-63
2072923-6	1991	We previously identified two of the cDNAs as the mouse VL30 retrovirus-like element and the mouse homolog of chondroitin sulfate proteoglycan core protein.	Chondroitin Sulfates	109-128	RIKEN cDNA A130040M12 gene	Mus musculus	55-59
1910291-2	1991	This paper provides evidence that chondrocytes synthesize the appropriate proteoglycan matrix under TGF-beta 1 stimulation: (i) there is a coordinated increase in hyaluronic acid and proteoglycan monomer synthesis, (ii) link-stable proteoglycan aggregates are assembled, (ii) the hybrid chondroitin sulfate/keratan sulfate monomeric species is synthesized, and (iv) there is an increase in protein core synthesis.	Chondroitin Sulfates	287-306	transforming growth factor beta 1	Bos taurus	100-110
2065359-5	1991	These observations and the previously reported molecular weight heterogeneity and protease sensitivity of the inhibitor argue that chondroitin sulphate AC-containing proteoglycans released from the tumor cell surface may inhibit cytolysin activity, contributing to the preferential resistance of the L5178Y-F9 to rat NK granule extract cytolysis.	Chondroitin Sulfates	131-151	perforin 1	Rattus norvegicus	229-238
1905136-0	1991	Stabilization of human prostatic acid phosphatase by coupling with chondroitin sulfate.	Chondroitin Sulfates	67-86	acid phosphatase 3	Homo sapiens	23-49
1905136-1	1991	Human prostatic acid phosphatase (PAP) (EC 3.1.3.2) was covalently linked to chondroitin sulfate A from whale cartilage.	Chondroitin Sulfates	77-98	acid phosphatase 3	Homo sapiens	6-32
1905136-1	1991	Human prostatic acid phosphatase (PAP) (EC 3.1.3.2) was covalently linked to chondroitin sulfate A from whale cartilage.	Chondroitin Sulfates	77-98	acid phosphatase 3	Homo sapiens	34-37
1905136-8	1991	Thus covalent modification of PAP by cross-linking to chondroitin sulfate could be the preferred method for stabilization of its biological activity.	Chondroitin Sulfates	54-73	acid phosphatase 3	Homo sapiens	30-33
1928843-4	1991	UTI is a proteoglycan containing a chondroitin sulfate side chain; the stability of the ITI complex is clearly dependent upon the integrity of the glycosaminoglycan part of UTI.	Chondroitin Sulfates	35-54	alpha-1-microglobulin/bikunin precursor	Homo sapiens	88-91
2013555-9	1991	The incorporation of [35S]methionine into chondroitin sulfate proteoglycan core proteins was stimulated by TGF-beta.	Chondroitin Sulfates	42-61	transforming growth factor beta 1	Homo sapiens	107-115
1832659-1	1991	Quantitative biosynthetic studies with cultures highly enriched for glial fibrillary acidic protein (GFAP+) cells of neonatal mammalian brain demonstrated production of four proteoglycans: hyaluronate (HA), heparan sulphate (HS), chondroitin sulphate (CS), and dermatan sulphate (DS).	Chondroitin Sulfates	230-250	glial fibrillary acidic protein	Homo sapiens	68-99
1832659-1	1991	Quantitative biosynthetic studies with cultures highly enriched for glial fibrillary acidic protein (GFAP+) cells of neonatal mammalian brain demonstrated production of four proteoglycans: hyaluronate (HA), heparan sulphate (HS), chondroitin sulphate (CS), and dermatan sulphate (DS).	Chondroitin Sulfates	252-254	glial fibrillary acidic protein	Homo sapiens	68-99
1813989-12	1991	SMC migration is also related to impaired assembly of elastin, the result of a chondroitin sulfate-induced decrease in elastin binding proteins and the production of a novel "defunct" 52 kD tropoelastin.	Chondroitin Sulfates	79-98	elastin	Rattus norvegicus	54-61
1813989-12	1991	SMC migration is also related to impaired assembly of elastin, the result of a chondroitin sulfate-induced decrease in elastin binding proteins and the production of a novel "defunct" 52 kD tropoelastin.	Chondroitin Sulfates	79-98	elastin	Rattus norvegicus	119-126
1708671-2	1990	Inter-alpha-trypsin inhibitor (ITI) consists of 3 polypeptides cross-linked by chondroitin sulphate, which is o-glycosidically linked to the smallest of the polypeptides, designated bikunin.	Chondroitin Sulfates	79-99	alpha-1-microglobulin/bikunin precursor	Homo sapiens	182-189
2013555-3	1991	However, TGF-beta consistently stimulated the synthesis of chondroitin sulfate proteoglycan.	Chondroitin Sulfates	59-78	transforming growth factor beta 1	Homo sapiens	9-17
2013555-4	1991	Both chondroitin 4- and chondroitin 6-sulfate were stimulated by TGF-beta to the same extent.	Chondroitin Sulfates	24-45	transforming growth factor beta 1	Homo sapiens	65-73
2125503-6	1990	At pH 5.2, granzyme A and perforin formed complexes with chondroitin sulfate A.	Chondroitin Sulfates	57-78	granzyme A	Homo sapiens	11-21
2125503-8	1990	Upon secretion of the granule contents induced by immobilized anti-CD3 antibodies, most granzyme A molecules remained complexed with the chondroitin sulfate A glycosaminoglycans, even if synthesis of intact proteoglycans was inhibited.	Chondroitin Sulfates	137-158	granzyme A	Homo sapiens	88-98
2287949-3	1990	Carbohydrate substituants (one or two chondroitin sulfate/dermatan sulfate chains for decorin and biglycan respectively, chains of keratan sulfate for fibromodulin and oligosaccharides) present variations from tissue to tissue and with age and other factors.	Chondroitin Sulfates	38-57	biglycan	Homo sapiens	98-106
2127920-2	1990	On thin sections, elastin fibers showed antigenic sites for monoclonal antibodies recognizing the unsaturated units remaining after digestion of hyaluronic acid with Streptomyces hyaluronidase and after digestion of dermatan and chondroitin sulfates with chondroitinase ABC.	Chondroitin Sulfates	229-249	elastin	Homo sapiens	18-25
1699522-8	1990	We conclude that Kupffer cells modulate the mitogenic activity of FSC in culture depending on the ratio of activated TGF beta and TGF alpha and affect chondroitin sulfate synthesis mainly by TGF beta.	Chondroitin Sulfates	151-170	transforming growth factor beta 1	Homo sapiens	191-199
2226299-1	1990	Human thyroglobulin (hTG) contains sulfate in chondroitin 6-sulfate chains and in complex carbohydrates.	Chondroitin Sulfates	46-67	thyroglobulin	Homo sapiens	6-19
2287590-3	1990	UDP-glucose dehydrogenase is particularly important in oxidizing UDP-glucose to UDP-glucuronic acid, the building block of hyaluronic acid and chondroitin sulfates.	Chondroitin Sulfates	143-163	UDP-glucose 6-dehydrogenase	Homo sapiens	0-25
2169732-0	1990	Presence and function of chondroitin-4-sulfate on recombinant human soluble thrombomodulin.	Chondroitin Sulfates	25-46	thrombomodulin	Homo sapiens	76-90
2226352-10	1990	In the medium fraction, TGF-beta increased the proportion of hyaluronic acid, chondroitin sulfate and dermatan sulfate released.	Chondroitin Sulfates	78-97	transforming growth factor beta 1	Homo sapiens	24-32
1698370-4	1990	Compared with sera from arthritic mice, which contain antibodies reactive with keratan sulfate, MAb 202 (IgG1) reacted only with a protein-related epitope that is distributed on both hyaluronic acid-binding and chondroitin sulfate-attachment regions.	Chondroitin Sulfates	211-230	LOC105243590	Mus musculus	105-109
2200848-9	1990	The chondroitin sulfate proteoglycan from the neonatal superior colliculus is the first proteoglycan to be identified as a neurotrophic factor.	Chondroitin Sulfates	4-23	neurotrophin 3	Rattus norvegicus	123-142
2119314-14	1990	Any differences in distribution of chondroitin sulfate-type proteoglycans between rds and normal mice can be accounted for by the absence of photoreceptor outer segments and progressive loss of photoreceptor cells in this mutant.	Chondroitin Sulfates	35-54	peripherin 2	Mus musculus	82-85
1974403-2	1990	Arteparon (GAGPS), heparin, heparan sulfate, chondroitin sulfate, and dextran sulfate, but not dextran, inhibited HLE-mediated hydrolysis of succinyl-ala2-val-pNA.	Chondroitin Sulfates	45-64	elastase, neutrophil expressed	Homo sapiens	114-117
2201287-0	1990	Non-uniform influence of transforming growth factor-beta on the biosynthesis of different forms of small chondroitin sulphate/dermatan sulphate proteoglycan.	Chondroitin Sulfates	105-125	transforming growth factor beta 1	Homo sapiens	25-56
2162845-6	1990	Analysis of mRNA encoding PG-40, the main chondroitin sulfate proteoglycan of colon tissue, revealed a 7-fold increase in the two transcripts encoding this gene product.	Chondroitin Sulfates	42-61	decorin	Homo sapiens	26-31
2351697-2	1990	Using small plastic implants to treat regions of developing mammary glands in situ, we now report that TGF-beta 1 growth inhibition is associated with an ectopic accumulation of type I collagen messenger RNA and protein, as well as the glycosaminoglycan, chondroitin sulfate.	Chondroitin Sulfates	255-274	transforming growth factor, beta 1	Mus musculus	103-113
2110415-4	1990	The material reacted with monoclonal antibody 9-A-2 after digestion by chondroitinase AC in one case and ABC in both cases, which is consistent with the identification of the glycosaminoglycans chondroitin 4-sulfate and dermatan sulfate.	Chondroitin Sulfates	194-215	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	105-108
2112379-0	1990	Presence of an endo-beta-galactosidase degrading the linkage region between the chondroitin sulfate chain and core peptide of proteoglycan.	Chondroitin Sulfates	80-99	galactosidase beta 1	Homo sapiens	20-38
1976012-4	1990	On the other hand, interaction of MTSP-1 with sulfated glycosaminoglycans, i.e., heparin and chondroitin sulfate, led to increased enzymatic activity and an altered fine specificity of MTSP-1 for peptide substrates.	Chondroitin Sulfates	93-112	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	34-40
1976012-4	1990	On the other hand, interaction of MTSP-1 with sulfated glycosaminoglycans, i.e., heparin and chondroitin sulfate, led to increased enzymatic activity and an altered fine specificity of MTSP-1 for peptide substrates.	Chondroitin Sulfates	93-112	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	185-191
1969657-4	1990	Syndecan consists of chondroitin sulfate and heparan sulphate chains linked to a 31 kilodalton (kDa) integral membrane protein.	Chondroitin Sulfates	21-40	syndecan 1	Homo sapiens	0-8
2350374-8	1990	Increase in chondroitin sulphate 4/6 was most marked at TGF-beta levels from 500-1000 pg/10(6) cells.	Chondroitin Sulfates	12-32	transforming growth factor beta 1	Homo sapiens	56-64
2317501-2	1990	At least 75% of the observed sulphation requires de novo synthesis of core protein and proceeds at a constant rate over at least 40 h. Heparan and dermatan sulphate proteoglycans (HSPG and DSPG, respectively) are the two major species produced, with only minor amounts (less than 5%) of chondroitin sulphate labelled under these conditions.	Chondroitin Sulfates	287-307	syndecan 2	Rattus norvegicus	180-184
1688536-1	1990	We have recently shown that the large hyaluronan-aggregating chondroitin sulfate proteoglycan from cartilage (PG-LA) is unfavorable as a substrate for neural crest cell migration in vitro and that this macromolecule inhibits cell dispersion on fibronectin substrates when included in the medium (R. Perris and S. Johansson, 1987, J.	Chondroitin Sulfates	61-80	fibronectin 1	Homo sapiens	244-255
1689191-6	1990	PF4 was demonstrated in a complex with a separate chondroitin sulfate antigen by crossed immunoelectrophoresis (CIE) experiments in which either anti-PF4 or anti-CS antisera was incorporated in the intermediate gel.	Chondroitin Sulfates	50-69	platelet factor 4	Homo sapiens	0-3
1689191-6	1990	PF4 was demonstrated in a complex with a separate chondroitin sulfate antigen by crossed immunoelectrophoresis (CIE) experiments in which either anti-PF4 or anti-CS antisera was incorporated in the intermediate gel.	Chondroitin Sulfates	162-164	platelet factor 4	Homo sapiens	0-3
1705516-4	1990	Furthermore almost all HNK-1 immunoreactive cells were also stained with a monoclonal antibody, 3B3, which is specific for chondroitin sulfate proteoglycan.	Chondroitin Sulfates	123-142	beta-1,3-glucuronyltransferase 1	Rattus norvegicus	23-28
2105202-0	1990	Inhibition of chondroitin sulfate incorporation into human thyroglobulin by p-nitrophenyl-beta-D-xylopyranoside.	Chondroitin Sulfates	14-33	thyroglobulin	Homo sapiens	59-72
2105202-1	1990	Human thyroglobulin (TG) is unique among glycoproteins and TGs of other species in having a chondroitin sulfate chain.	Chondroitin Sulfates	92-111	thyroglobulin	Homo sapiens	6-19
1696488-7	1990	These results demonstrate that TGF-beta 1 and TGF-beta 2 stimulate the production of not only collagenous extracellular matrix components, but also dramatically increase the in vivo synthesis of hyaluronate and chondroitin sulfate.	Chondroitin Sulfates	211-230	transforming growth factor beta-1 proprotein	Cavia porcellus	31-41
1696488-7	1990	These results demonstrate that TGF-beta 1 and TGF-beta 2 stimulate the production of not only collagenous extracellular matrix components, but also dramatically increase the in vivo synthesis of hyaluronate and chondroitin sulfate.	Chondroitin Sulfates	211-230	transforming growth factor, beta 2	Mus musculus	46-56
28488903-1	2018	Versican, a large chondroitin sulfate (CS) proteoglycan, serves as a structural macromolecule of the extracellular matrix (ECM) and regulates cell behavior.	Chondroitin Sulfates	18-37	versican	Mus musculus	0-8
33815067-1	2021	Although the increased expression of members of the chondroitin sulfate proteoglycan family, such as neuron-glial antigen 2 (NG2), have been well documented after an injury to the spinal cord, a complete picture as to the cellular origins and function of this NG2 expression has yet to be made.	Chondroitin Sulfates	52-71	chondroitin sulfate proteoglycan 4	Mus musculus	260-263
33809195-2	2021	We demonstrate that the chondroitin polymerizing factor (CHPF), an enzyme that mediates the elongation of chondroitin sulfate (CS), is a critical elicitor of the malignant characteristics of HCC as it modifies the potent tumor suppressor, decorin (DCN).	Chondroitin Sulfates	106-125	chondroitin polymerizing factor	Homo sapiens	24-55
33809195-2	2021	We demonstrate that the chondroitin polymerizing factor (CHPF), an enzyme that mediates the elongation of chondroitin sulfate (CS), is a critical elicitor of the malignant characteristics of HCC as it modifies the potent tumor suppressor, decorin (DCN).	Chondroitin Sulfates	106-125	chondroitin polymerizing factor	Homo sapiens	57-61
33815067-1	2021	Although the increased expression of members of the chondroitin sulfate proteoglycan family, such as neuron-glial antigen 2 (NG2), have been well documented after an injury to the spinal cord, a complete picture as to the cellular origins and function of this NG2 expression has yet to be made.	Chondroitin Sulfates	52-71	chondroitin sulfate proteoglycan 4	Mus musculus	101-123
33815067-1	2021	Although the increased expression of members of the chondroitin sulfate proteoglycan family, such as neuron-glial antigen 2 (NG2), have been well documented after an injury to the spinal cord, a complete picture as to the cellular origins and function of this NG2 expression has yet to be made.	Chondroitin Sulfates	52-71	chondroitin sulfate proteoglycan 4	Mus musculus	125-128
33809195-2	2021	We demonstrate that the chondroitin polymerizing factor (CHPF), an enzyme that mediates the elongation of chondroitin sulfate (CS), is a critical elicitor of the malignant characteristics of HCC as it modifies the potent tumor suppressor, decorin (DCN).	Chondroitin Sulfates	106-125	citrate synthase	Homo sapiens	127-129
33809195-2	2021	We demonstrate that the chondroitin polymerizing factor (CHPF), an enzyme that mediates the elongation of chondroitin sulfate (CS), is a critical elicitor of the malignant characteristics of HCC as it modifies the potent tumor suppressor, decorin (DCN).	Chondroitin Sulfates	106-125	decorin	Homo sapiens	239-246
33809195-2	2021	We demonstrate that the chondroitin polymerizing factor (CHPF), an enzyme that mediates the elongation of chondroitin sulfate (CS), is a critical elicitor of the malignant characteristics of HCC as it modifies the potent tumor suppressor, decorin (DCN).	Chondroitin Sulfates	106-125	decorin	Homo sapiens	248-251
28488903-1	2018	Versican, a large chondroitin sulfate (CS) proteoglycan, serves as a structural macromolecule of the extracellular matrix (ECM) and regulates cell behavior.	Chondroitin Sulfates	39-41	versican	Mus musculus	0-8
34601887-1	2022	The aim of this work was to study the biophysical properties of the chitosan-grafted poly(lactic acid) (CH-g-PLA) nanofibers loaded with silver nanoparticles (AgNPs) and chondroitin-4-sulfate (C4S).	Chondroitin Sulfates	193-196	carbohydrate sulfotransferase 11	Mus musculus	170-183
29787913-0	2018	Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition.	Chondroitin Sulfates	53-72	serpin family D member 1	Homo sapiens	82-101
29787913-0	2018	Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition.	Chondroitin Sulfates	53-72	coagulation factor II, thrombin	Homo sapiens	112-120
20872747-0	2010	TGF-beta3 immobilized PLGA-gelatin/chondroitin sulfate/hyaluronic acid hybrid scaffold for cartilage regeneration.	Chondroitin Sulfates	35-54	transforming growth factor beta-3	Oryctolagus cuniculus	0-9
20872747-2	2010	This study is to evaluate the potentials of TGF-beta3 immobilized poly-(lactic-co-glycolic acid)-gelatin/chondroitin sulfate/hyaluronic acid (PLGA-GCH) hybrid scaffold for cartilage regeneration.	Chondroitin Sulfates	105-124	transforming growth factor beta-3	Oryctolagus cuniculus	44-53
19170184-1	2009	In the postnatal central nervous system, glial cells expressing the chondroitin sulfate proteoglycan NG2 (NG2-cells) constitute a cell population exhibiting several properties of oligodendrocyte precursors such as the ability to proliferate.	Chondroitin Sulfates	68-87	chondroitin sulfate proteoglycan 4	Mus musculus	101-104
19170184-1	2009	In the postnatal central nervous system, glial cells expressing the chondroitin sulfate proteoglycan NG2 (NG2-cells) constitute a cell population exhibiting several properties of oligodendrocyte precursors such as the ability to proliferate.	Chondroitin Sulfates	68-87	chondroitin sulfate proteoglycan 4	Mus musculus	106-109
34952462-2	2022	Here, we demonstrate that the cytosolic isoform of the vertebrate-specific oxidoreductase Glutaredoxin 2 (Grx2c) regulates the redox state of the transcription factor SP-1 and thereby its binding affinity to both the promoter and an enhancer region of the CSPG4 gene encoding chondroitin sulfate proteoglycan nerve/glial antigen 2 (NG2).	Chondroitin Sulfates	276-295	chondroitin sulfate proteoglycan 4	Homo sapiens	256-261
34952462-2	2022	Here, we demonstrate that the cytosolic isoform of the vertebrate-specific oxidoreductase Glutaredoxin 2 (Grx2c) regulates the redox state of the transcription factor SP-1 and thereby its binding affinity to both the promoter and an enhancer region of the CSPG4 gene encoding chondroitin sulfate proteoglycan nerve/glial antigen 2 (NG2).	Chondroitin Sulfates	276-295	chondroitin sulfate proteoglycan 4	Homo sapiens	332-335
34392362-1	2021	Chondroitinase ABC I (cABC-I) is the enzyme which cleaves the beta-1,4 glycosidic linkage of chondroitin sulfate (CS) by beta-elimination.	Chondroitin Sulfates	93-112	citrate synthase	Homo sapiens	114-116
34806902-3	2021	ADAMTS5 cleaves chondroitin sulphate proteoglycans (CSPGs) such as versican.	Chondroitin Sulfates	16-36	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)	Mus musculus	0-7
34933913-0	2022	Remodeling chondroitin-6-sulfate-mediated immune exclusion enhances anti-PD-1 response in colorectal cancer with microsatellite stability.	Chondroitin Sulfates	11-32	programmed cell death 1	Homo sapiens	73-77
34933913-4	2022	Furthermore, C-6-S derived from cancer-associated fibroblasts (CAFs) promoted co-nuclear translocation of pSTAT3 and GLI1, activating the JAK/STAT3 and Hedgehog pathways.	Chondroitin Sulfates	13-18	GLI family zinc finger 1	Homo sapiens	117-121
34933913-4	2022	Furthermore, C-6-S derived from cancer-associated fibroblasts (CAFs) promoted co-nuclear translocation of pSTAT3 and GLI1, activating the JAK/STAT3 and Hedgehog pathways.	Chondroitin Sulfates	13-18	signal transducer and activator of transcription 3	Homo sapiens	142-147
34933913-5	2022	In vivo experiments with C-6-S-targeted strategies decreased M2 macrophages and reprogrammed the immunosuppressive TME, leading to enhanced response to anti-PD-1 in MSS CRC.	Chondroitin Sulfates	25-30	programmed cell death 1	Homo sapiens	157-161
34392362-3	2021	cABC-I showed the highest reactivity to CSA and CSC among all CS isomers, and the kcat/Km of cABC-I was higher for CSA than for CSC.	Chondroitin Sulfates	40-43	citrate synthase	Homo sapiens	62-64
34392362-3	2021	cABC-I showed the highest reactivity to CSA and CSC among all CS isomers, and the kcat/Km of cABC-I was higher for CSA than for CSC.	Chondroitin Sulfates	48-51	citrate synthase	Homo sapiens	62-64
34392362-3	2021	cABC-I showed the highest reactivity to CSA and CSC among all CS isomers, and the kcat/Km of cABC-I was higher for CSA than for CSC.	Chondroitin Sulfates	115-118	citrate synthase	Homo sapiens	62-64
34741771-2	2022	Herein, we describe the development of a customized chondroitin sulfate-incorporated type II atelocollagen (COL II/CS) scaffold with excellent chondrogenic capacity and a type I atelocollagen (COL I) scaffold to facilitate the formation of vascularized fibrous tissue.	Chondroitin Sulfates	52-71	citrate synthase	Homo sapiens	108-117
34966741-4	2021	We found that the expression of seven chondroitin sulfate biosynthetic enzymes, namely B4GALT7, B3GALT6, B3GAT3, CHSY3, CHSY1, CHPF, and CHPF2, were significantly increased, while four other enzymes (XYLT1, CHST7, CHST15, and UST) were decreased in the colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) patients.	Chondroitin Sulfates	38-57	beta-1,4-galactosyltransferase 7	Homo sapiens	87-94
34966741-4	2021	We found that the expression of seven chondroitin sulfate biosynthetic enzymes, namely B4GALT7, B3GALT6, B3GAT3, CHSY3, CHSY1, CHPF, and CHPF2, were significantly increased, while four other enzymes (XYLT1, CHST7, CHST15, and UST) were decreased in the colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) patients.	Chondroitin Sulfates	38-57	beta-1,3-galactosyltransferase 6	Homo sapiens	96-103
34966741-4	2021	We found that the expression of seven chondroitin sulfate biosynthetic enzymes, namely B4GALT7, B3GALT6, B3GAT3, CHSY3, CHSY1, CHPF, and CHPF2, were significantly increased, while four other enzymes (XYLT1, CHST7, CHST15, and UST) were decreased in the colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) patients.	Chondroitin Sulfates	38-57	beta-1,3-glucuronyltransferase 3	Homo sapiens	105-111
34966741-4	2021	We found that the expression of seven chondroitin sulfate biosynthetic enzymes, namely B4GALT7, B3GALT6, B3GAT3, CHSY3, CHSY1, CHPF, and CHPF2, were significantly increased, while four other enzymes (XYLT1, CHST7, CHST15, and UST) were decreased in the colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) patients.	Chondroitin Sulfates	38-57	chondroitin sulfate synthase 3	Homo sapiens	113-118
34966741-4	2021	We found that the expression of seven chondroitin sulfate biosynthetic enzymes, namely B4GALT7, B3GALT6, B3GAT3, CHSY3, CHSY1, CHPF, and CHPF2, were significantly increased, while four other enzymes (XYLT1, CHST7, CHST15, and UST) were decreased in the colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) patients.	Chondroitin Sulfates	38-57	chondroitin sulfate synthase 1	Homo sapiens	120-125
34966741-4	2021	We found that the expression of seven chondroitin sulfate biosynthetic enzymes, namely B4GALT7, B3GALT6, B3GAT3, CHSY3, CHSY1, CHPF, and CHPF2, were significantly increased, while four other enzymes (XYLT1, CHST7, CHST15, and UST) were decreased in the colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) patients.	Chondroitin Sulfates	38-57	chondroitin polymerizing factor 2	Homo sapiens	137-142
34966741-4	2021	We found that the expression of seven chondroitin sulfate biosynthetic enzymes, namely B4GALT7, B3GALT6, B3GAT3, CHSY3, CHSY1, CHPF, and CHPF2, were significantly increased, while four other enzymes (XYLT1, CHST7, CHST15, and UST) were decreased in the colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) patients.	Chondroitin Sulfates	38-57	xylosyltransferase 1	Homo sapiens	200-205
34966741-4	2021	We found that the expression of seven chondroitin sulfate biosynthetic enzymes, namely B4GALT7, B3GALT6, B3GAT3, CHSY3, CHSY1, CHPF, and CHPF2, were significantly increased, while four other enzymes (XYLT1, CHST7, CHST15, and UST) were decreased in the colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) patients.	Chondroitin Sulfates	38-57	carbohydrate sulfotransferase 7	Homo sapiens	207-212
34966741-4	2021	We found that the expression of seven chondroitin sulfate biosynthetic enzymes, namely B4GALT7, B3GALT6, B3GAT3, CHSY3, CHSY1, CHPF, and CHPF2, were significantly increased, while four other enzymes (XYLT1, CHST7, CHST15, and UST) were decreased in the colon adenocarcinoma (COAD) and rectum adenocarcinoma (READ) patients.	Chondroitin Sulfates	38-57	carbohydrate sulfotransferase 15	Homo sapiens	214-220
34966741-5	2021	In the human placenta, where the distinct chondroitin sulfate is specifically bound with VAR2CSA on Plasmodium parasite-infected RBC, eight chondroitin sulfate biosynthesis enzymes (CSGALNACT1, CSGALNACT2, CHSY3, CHSY1, CHPF, DSE, CHST11, and CHST3) were significantly higher than the normal colon tissue.	Chondroitin Sulfates	42-61	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	182-192
34966741-5	2021	In the human placenta, where the distinct chondroitin sulfate is specifically bound with VAR2CSA on Plasmodium parasite-infected RBC, eight chondroitin sulfate biosynthesis enzymes (CSGALNACT1, CSGALNACT2, CHSY3, CHSY1, CHPF, DSE, CHST11, and CHST3) were significantly higher than the normal colon tissue.	Chondroitin Sulfates	42-61	chondroitin sulfate N-acetylgalactosaminyltransferase 2	Homo sapiens	194-204
34966741-5	2021	In the human placenta, where the distinct chondroitin sulfate is specifically bound with VAR2CSA on Plasmodium parasite-infected RBC, eight chondroitin sulfate biosynthesis enzymes (CSGALNACT1, CSGALNACT2, CHSY3, CHSY1, CHPF, DSE, CHST11, and CHST3) were significantly higher than the normal colon tissue.	Chondroitin Sulfates	42-61	chondroitin sulfate synthase 3	Homo sapiens	206-211
34966741-5	2021	In the human placenta, where the distinct chondroitin sulfate is specifically bound with VAR2CSA on Plasmodium parasite-infected RBC, eight chondroitin sulfate biosynthesis enzymes (CSGALNACT1, CSGALNACT2, CHSY3, CHSY1, CHPF, DSE, CHST11, and CHST3) were significantly higher than the normal colon tissue.	Chondroitin Sulfates	42-61	chondroitin sulfate synthase 1	Homo sapiens	213-218
34966741-5	2021	In the human placenta, where the distinct chondroitin sulfate is specifically bound with VAR2CSA on Plasmodium parasite-infected RBC, eight chondroitin sulfate biosynthesis enzymes (CSGALNACT1, CSGALNACT2, CHSY3, CHSY1, CHPF, DSE, CHST11, and CHST3) were significantly higher than the normal colon tissue.	Chondroitin Sulfates	42-61	dermatan sulfate epimerase	Homo sapiens	226-229
34966741-5	2021	In the human placenta, where the distinct chondroitin sulfate is specifically bound with VAR2CSA on Plasmodium parasite-infected RBC, eight chondroitin sulfate biosynthesis enzymes (CSGALNACT1, CSGALNACT2, CHSY3, CHSY1, CHPF, DSE, CHST11, and CHST3) were significantly higher than the normal colon tissue.	Chondroitin Sulfates	42-61	carbohydrate sulfotransferase 11	Homo sapiens	231-237
34966741-5	2021	In the human placenta, where the distinct chondroitin sulfate is specifically bound with VAR2CSA on Plasmodium parasite-infected RBC, eight chondroitin sulfate biosynthesis enzymes (CSGALNACT1, CSGALNACT2, CHSY3, CHSY1, CHPF, DSE, CHST11, and CHST3) were significantly higher than the normal colon tissue.	Chondroitin Sulfates	42-61	carbohydrate sulfotransferase 3	Homo sapiens	243-248
34938257-2	2021	Previously, we have shown that heparin-binding growth-associated molecule (HB-GAM) reverses the CSPG (chondroitin sulfate proteoglycan) inhibition on neurite outgrowth in the culture medium of primary CNS neurons and enhances axon growth through the injured spinal cord in mice demonstrated by two-photon imaging.	Chondroitin Sulfates	102-121	pleiotrophin	Mus musculus	31-73
34938257-2	2021	Previously, we have shown that heparin-binding growth-associated molecule (HB-GAM) reverses the CSPG (chondroitin sulfate proteoglycan) inhibition on neurite outgrowth in the culture medium of primary CNS neurons and enhances axon growth through the injured spinal cord in mice demonstrated by two-photon imaging.	Chondroitin Sulfates	102-121	pleiotrophin	Mus musculus	75-81
34762909-9	2021	CRISPR/Cas9 targeting of CHPF and CHPF2 in tumor cells reduced the average molecular weight of cell-surface chondroitin sulfate and resulted in a marked reduction of rVAR2 binding.	Chondroitin Sulfates	108-127	chondroitin polymerizing factor 2	Homo sapiens	34-39
34901009-7	2021	These observations suggest that CS/DS are essential for skeletal development as well as the assembly of collagen fibrils in the skin, and that their respective knockout mice can be utilized as models for human genetic disorders with mutations in chondroitin synthase 1 and DS-epimerase 1.	Chondroitin Sulfates	32-34	chondroitin sulfate synthase 1	Homo sapiens	246-268
34948256-3	2021	The enzyme deficit causes a pathological accumulation of the undegraded glycosaminoglycans dermatan-sulphate and chondroitin-sulphate, natural substrates of ASB activity.	Chondroitin Sulfates	113-133	arylsulfatase B	Homo sapiens	157-160
34955750-8	2021	In reactive astrocytes, HGF-enhanced NPC-CM effectively reduced glial fibrillary acidic protein (GFAP) expression and chondroitin sulfate proteoglycan deposition to a greater extent than either treatment alone, and enhanced neurite outgrowth of co-cultured neurons.	Chondroitin Sulfates	118-137	hepatocyte growth factor	Homo sapiens	24-27
34788765-7	2022	Expression of CHST15 and CHST11 which are required for synthesis of CSE and chondroitin 4-sulfate, total sulfated GAGs, and sulfotransferase activity was significantly increased following AngII exposure in vascular smooth muscle cells.	Chondroitin Sulfates	76-97	carbohydrate sulfotransferase 15	Homo sapiens	14-20
34788765-9	2022	DISCUSSION/CONCLUSION: Decline in ARSB and resulting increases in CS may contribute to the pathobiology of COVID-19, as IL-6 does.	Chondroitin Sulfates	66-68	arylsulfatase B	Homo sapiens	34-38
34833865-7	2021	Additionally, chondroitin sulfate showed its antioxidant potential by restoring the various biochemical levels and anti-inflammatory properties by reducing NF-kB levels and pro-inflammatory mediators like TNF-alpha, IL-1beta, and IL-6, indicating the neuroprotective effect as well as the suppressed levels of caspase-3, which indicated a neuroprotective treatment strategy in epilepsy.	Chondroitin Sulfates	14-33	tumor necrosis factor	Mus musculus	205-214
34833865-7	2021	Additionally, chondroitin sulfate showed its antioxidant potential by restoring the various biochemical levels and anti-inflammatory properties by reducing NF-kB levels and pro-inflammatory mediators like TNF-alpha, IL-1beta, and IL-6, indicating the neuroprotective effect as well as the suppressed levels of caspase-3, which indicated a neuroprotective treatment strategy in epilepsy.	Chondroitin Sulfates	14-33	interleukin 1 alpha	Mus musculus	216-224
34833865-7	2021	Additionally, chondroitin sulfate showed its antioxidant potential by restoring the various biochemical levels and anti-inflammatory properties by reducing NF-kB levels and pro-inflammatory mediators like TNF-alpha, IL-1beta, and IL-6, indicating the neuroprotective effect as well as the suppressed levels of caspase-3, which indicated a neuroprotective treatment strategy in epilepsy.	Chondroitin Sulfates	14-33	interleukin 6	Mus musculus	230-234
34833865-7	2021	Additionally, chondroitin sulfate showed its antioxidant potential by restoring the various biochemical levels and anti-inflammatory properties by reducing NF-kB levels and pro-inflammatory mediators like TNF-alpha, IL-1beta, and IL-6, indicating the neuroprotective effect as well as the suppressed levels of caspase-3, which indicated a neuroprotective treatment strategy in epilepsy.	Chondroitin Sulfates	14-33	caspase 3	Mus musculus	310-319
34833865-9	2021	Further, the molecular docking of chondroitin sulfate at the active pockets of TNF-alpha, IL-1beta, and IL-6 showed excellent interactions with critical amino acid residues.	Chondroitin Sulfates	34-53	tumor necrosis factor	Mus musculus	79-88
34833865-9	2021	Further, the molecular docking of chondroitin sulfate at the active pockets of TNF-alpha, IL-1beta, and IL-6 showed excellent interactions with critical amino acid residues.	Chondroitin Sulfates	34-53	interleukin 1 alpha	Mus musculus	90-98
34833865-9	2021	Further, the molecular docking of chondroitin sulfate at the active pockets of TNF-alpha, IL-1beta, and IL-6 showed excellent interactions with critical amino acid residues.	Chondroitin Sulfates	34-53	interleukin 6	Mus musculus	104-108
34668009-8	2021	Additionally, heparinase and chondroitinase abolished OPG effects on VSMCs-ROS production, confirming syndecan-1 as OPG molecular partner and suggesting that OPG binds to heparan/chondroitin sulphate chains of syndecan-1.	Chondroitin Sulfates	179-199	galactosamine (N-acetyl)-6-sulfatase	Rattus norvegicus	29-43
34651208-0	2021	Discrimination of sulfated isomers of chondroitin sulfate disaccharides by HILIC-MS. Chondroitin sulfate (CS) glycosaminoglycans are biologically active sulfated polysaccharides that pose an analytical challenge for their structural analysis and functional evaluation.	Chondroitin Sulfates	85-104	citrate synthase	Homo sapiens	106-108
34668009-8	2021	Additionally, heparinase and chondroitinase abolished OPG effects on VSMCs-ROS production, confirming syndecan-1 as OPG molecular partner and suggesting that OPG binds to heparan/chondroitin sulphate chains of syndecan-1.	Chondroitin Sulfates	179-199	TNF receptor superfamily member 11B	Rattus norvegicus	54-57
34668009-8	2021	Additionally, heparinase and chondroitinase abolished OPG effects on VSMCs-ROS production, confirming syndecan-1 as OPG molecular partner and suggesting that OPG binds to heparan/chondroitin sulphate chains of syndecan-1.	Chondroitin Sulfates	179-199	TNF receptor superfamily member 11B	Rattus norvegicus	158-161
34668009-8	2021	Additionally, heparinase and chondroitinase abolished OPG effects on VSMCs-ROS production, confirming syndecan-1 as OPG molecular partner and suggesting that OPG binds to heparan/chondroitin sulphate chains of syndecan-1.	Chondroitin Sulfates	179-199	syndecan 1	Rattus norvegicus	210-220
34777254-3	2021	The results showed that chondroitin sulfate can reduce blood glucose and relieve symptoms of diabetic rats; in addition, it can significantly increase the bone mineral density, improve bone microstructure, and reduce bone marrow adipocyte number in diabetic rats; after 10 weeks of chondroitin sulfate administration, the SOD activity level was upregulated, as well as CAT levels, indicating that chondroitin sulfate can alleviate oxidative stress in diabetic rats.	Chondroitin Sulfates	24-43	catalase	Rattus norvegicus	369-372
34777254-3	2021	The results showed that chondroitin sulfate can reduce blood glucose and relieve symptoms of diabetic rats; in addition, it can significantly increase the bone mineral density, improve bone microstructure, and reduce bone marrow adipocyte number in diabetic rats; after 10 weeks of chondroitin sulfate administration, the SOD activity level was upregulated, as well as CAT levels, indicating that chondroitin sulfate can alleviate oxidative stress in diabetic rats.	Chondroitin Sulfates	282-301	catalase	Rattus norvegicus	369-372
34777254-3	2021	The results showed that chondroitin sulfate can reduce blood glucose and relieve symptoms of diabetic rats; in addition, it can significantly increase the bone mineral density, improve bone microstructure, and reduce bone marrow adipocyte number in diabetic rats; after 10 weeks of chondroitin sulfate administration, the SOD activity level was upregulated, as well as CAT levels, indicating that chondroitin sulfate can alleviate oxidative stress in diabetic rats.	Chondroitin Sulfates	397-416	catalase	Rattus norvegicus	369-372
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	0-19	tumor necrosis factor	Rattus norvegicus	88-97
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	0-19	interleukin 6	Rattus norvegicus	105-109
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	0-19	mast cell protease 1-like 1	Rattus norvegicus	115-120
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	0-19	TNF superfamily member 11	Rattus norvegicus	297-302
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	0-19	PDZ and LIM domain 3	Rattus norvegicus	311-314
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	224-243	tumor necrosis factor	Rattus norvegicus	88-97
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	224-243	interleukin 6	Rattus norvegicus	105-109
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	224-243	mast cell protease 1-like 1	Rattus norvegicus	115-120
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	224-243	TNF superfamily member 11	Rattus norvegicus	297-302
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	224-243	PDZ and LIM domain 3	Rattus norvegicus	311-314
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	368-387	tumor necrosis factor	Rattus norvegicus	88-97
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	368-387	interleukin 6	Rattus norvegicus	105-109
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	368-387	mast cell protease 1-like 1	Rattus norvegicus	115-120
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	368-387	TNF superfamily member 11	Rattus norvegicus	297-302
34777254-4	2021	Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-alpha, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration).	Chondroitin Sulfates	368-387	PDZ and LIM domain 3	Rattus norvegicus	311-314
34777254-5	2021	At the same time, the bone OPG and RUNX 2 expression levels were higher after chondroitin sulfate treatment, the bone RANKL expression was lowered, and the OPG/RANKL ratio was upregulated.	Chondroitin Sulfates	78-97	TNF receptor superfamily member 11B	Rattus norvegicus	27-30
34777254-5	2021	At the same time, the bone OPG and RUNX 2 expression levels were higher after chondroitin sulfate treatment, the bone RANKL expression was lowered, and the OPG/RANKL ratio was upregulated.	Chondroitin Sulfates	78-97	RUNX family transcription factor 2	Rattus norvegicus	35-41
34777254-5	2021	At the same time, the bone OPG and RUNX 2 expression levels were higher after chondroitin sulfate treatment, the bone RANKL expression was lowered, and the OPG/RANKL ratio was upregulated.	Chondroitin Sulfates	78-97	TNF superfamily member 11	Rattus norvegicus	118-123
34777254-5	2021	At the same time, the bone OPG and RUNX 2 expression levels were higher after chondroitin sulfate treatment, the bone RANKL expression was lowered, and the OPG/RANKL ratio was upregulated.	Chondroitin Sulfates	78-97	TNF receptor superfamily member 11B	Rattus norvegicus	156-159
34777254-5	2021	At the same time, the bone OPG and RUNX 2 expression levels were higher after chondroitin sulfate treatment, the bone RANKL expression was lowered, and the OPG/RANKL ratio was upregulated.	Chondroitin Sulfates	78-97	TNF superfamily member 11	Rattus norvegicus	160-165
34746156-1	2021	In this review, the current experimental evidence, literature and hypotheses surrounding hyaluronidase 4 (HYAL4, also known as chondroitin sulphate hydrolase (CHSE)) and chondroitin sulphate (CS) are explored.	Chondroitin Sulfates	170-190	citrate synthase	Homo sapiens	192-194
34533297-2	2021	Herein, we designed a pH-sensitive polymeric vesicle (PV) self-assembled by histamine-modified chondroitin sulfate (CS-his) for codelivery of GOx and l-buthionine sulfoximine (BSO).	Chondroitin Sulfates	95-114	hydroxyacid oxidase 1, liver	Mus musculus	142-145
34647812-2	2021	To reduce CPA toxicity, supplementation with research-grade additives, in particular chondroitin sulfate (CS) and ascorbic acid (AA), have previously been shown to improve chondrocyte recovery and metabolic function after exposure to CPAs at hypothermic conditions.	Chondroitin Sulfates	85-104	citrate synthase	Homo sapiens	106-108
34660989-1	2021	Chondroitin sulfate (CS) and hyaluronic acid (HA) methacrylate (MA) hydrogels are under investigation for biomedical applications.	Chondroitin Sulfates	0-19	citrate synthase	Homo sapiens	21-23
34524427-3	2022	SRGN, a chondroitin sulfate proteoglycan Serglycin, was identified as a markedly overexpressed gene in TTF-1-negative LUAD.	Chondroitin Sulfates	8-27	serglycin	Mus musculus	0-4
34564711-1	2021	Chondroitin polymerizing factor (CHPF) is an important glycosyltransferase involved in the biosynthesis of chondroitin sulfate.	Chondroitin Sulfates	107-126	chondroitin polymerizing factor	Homo sapiens	0-31
34564711-1	2021	Chondroitin polymerizing factor (CHPF) is an important glycosyltransferase involved in the biosynthesis of chondroitin sulfate.	Chondroitin Sulfates	107-126	chondroitin polymerizing factor	Homo sapiens	33-37
34524427-3	2022	SRGN, a chondroitin sulfate proteoglycan Serglycin, was identified as a markedly overexpressed gene in TTF-1-negative LUAD.	Chondroitin Sulfates	8-27	NK2 homeobox 1	Mus musculus	103-108
34595111-0	2021	Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation.	Chondroitin Sulfates	33-52	cyclin dependent kinase 1	Homo sapiens	67-71
34595111-8	2021	CS inhibited the gene and protein expression levels of CDKs and increased the ratios of apoptotic or dead HCT-116 cells by regulating mitogen-activated protein (MAP) kinase pathways.	Chondroitin Sulfates	0-2	cyclin dependent kinase 1	Homo sapiens	55-59
34503301-2	2021	Most human solid tumors express proteoglycans modified with distinct oncofetal chondroitin sulfate (CS) chains that can be detected and targeted with recombinant VAR2CSA (rVAR2) proteins and rVAR2-derived therapeutics.	Chondroitin Sulfates	79-98	citrate synthase	Homo sapiens	100-102
34666527-1	2021	Versican, a chondroitin sulfate proteoglycan, is an essential component of the extracellular matrix (ECM) in inflammatory lung disease.	Chondroitin Sulfates	12-31	versican	Homo sapiens	0-8
34346557-8	2021	We identified and validated new compounds, tretinoin, chondroitin sulfate, and hyaluronic acid, for their ability to restore age-related decline of collagen homeostasis and increase lifespan.	Chondroitin Sulfates	54-73	Col_cuticle_N domain-containing protein	Caenorhabditis elegans	148-156
34439850-2	2021	Herein, we proposed a ternary hydrogel of gellan gum (GG), silk fibroin (SF), and chondroitin sulfate (CS) as a biomaterial for cartilage tissue engineering.	Chondroitin Sulfates	82-101	citrate synthase	Homo sapiens	103-105
34474822-5	2021	We have developed a unique wound dressing, using chitosan (CH) and chondroitin sulfate (CS), that can form a porous scaffold (CH-CS PEC) in-situ, at the wound site, by simple mixing of the polymer solutions.	Chondroitin Sulfates	67-86	citrate synthase	Rattus norvegicus	88-90
34474822-5	2021	We have developed a unique wound dressing, using chitosan (CH) and chondroitin sulfate (CS), that can form a porous scaffold (CH-CS PEC) in-situ, at the wound site, by simple mixing of the polymer solutions.	Chondroitin Sulfates	67-86	citrate synthase	Rattus norvegicus	129-131
34213045-0	2021	Midkine Interaction with Chondroitin Sulfate Model Synthetic Tetrasaccharides and Their Mimetics: The Role of Aromatic Interactions.	Chondroitin Sulfates	25-44	midkine	Mus musculus	0-7
34548858-2	2021	chondroitin sulfate (CS), has been used in managing joint pain and osteoarthritis.	Chondroitin Sulfates	0-19	citrate synthase	Rattus norvegicus	21-23
34449621-1	2021	The purpose of the current investigation was to develop chondroitin sulfate/carbopol-co-poly(acrylic acid) (CS/CBP-co-PAA) hydrogels for controlled delivery of diclofenac sodium (DS).	Chondroitin Sulfates	56-75	citrate synthase	Homo sapiens	108-110
34409033-1	2021	Chondroitin sulfate (CS) is the most abundant and widely distributed glycosaminoglycan (GAG) in the human body.	Chondroitin Sulfates	0-19	citrate synthase	Homo sapiens	21-23
34119546-0	2021	Inhibitory effects of chondroitin sulfate on alpha-amylase activity: A potential hypoglycemic agent.	Chondroitin Sulfates	22-41	alpha amylase	Bos taurus	45-58
34119546-2	2021	Here, we compared the structural information of chondroitin sulfate (CS) from different origins and the effects on activity of alpha-amylase and blood glucose have been investigated.	Chondroitin Sulfates	48-67	citrate synthase	Bos taurus	69-71
34119546-2	2021	Here, we compared the structural information of chondroitin sulfate (CS) from different origins and the effects on activity of alpha-amylase and blood glucose have been investigated.	Chondroitin Sulfates	48-67	alpha amylase	Bos taurus	127-140
34452074-3	2021	The present study offers two novel therapies based in advanced drug delivery systems for RA treatment: encapsulated chondroitin sulfate modified poly(amidoamine) dendrimer nanoparticles (NPs) covalently bonded to monoclonal anti-TNF alpha antibody in both Tyramine-Gellan Gum and Tyramine-Gellan Gum/Silk Fibroin hydrogels.	Chondroitin Sulfates	116-135	tumor necrosis factor	Homo sapiens	229-238
34102261-1	2021	Emerging evidence supports an increased role for NG2/CSPG4-expressing cells in the process of neuroregeneration and synaptic plasticity, due to the increased production of multifunctional chondroitin sulfate proteoglycan (NG2/CSPG4).	Chondroitin Sulfates	188-207	chondroitin sulfate proteoglycan 4	Rattus norvegicus	49-52
34102261-1	2021	Emerging evidence supports an increased role for NG2/CSPG4-expressing cells in the process of neuroregeneration and synaptic plasticity, due to the increased production of multifunctional chondroitin sulfate proteoglycan (NG2/CSPG4).	Chondroitin Sulfates	188-207	chondroitin sulfate proteoglycan 4	Rattus norvegicus	53-58
34102261-1	2021	Emerging evidence supports an increased role for NG2/CSPG4-expressing cells in the process of neuroregeneration and synaptic plasticity, due to the increased production of multifunctional chondroitin sulfate proteoglycan (NG2/CSPG4).	Chondroitin Sulfates	188-207	chondroitin sulfate proteoglycan 4	Rattus norvegicus	222-225
34102261-1	2021	Emerging evidence supports an increased role for NG2/CSPG4-expressing cells in the process of neuroregeneration and synaptic plasticity, due to the increased production of multifunctional chondroitin sulfate proteoglycan (NG2/CSPG4).	Chondroitin Sulfates	188-207	chondroitin sulfate proteoglycan 4	Rattus norvegicus	226-231
34299163-0	2021	Combinatorial Virtual Library Screening Study of Transforming Growth Factor-beta2-Chondroitin Sulfate System.	Chondroitin Sulfates	82-101	transforming growth factor beta 2	Homo sapiens	49-81
34299163-2	2021	In a recent study, we found that preterm human milk TGF-beta2 is sequestered by chondroitin sulfate (CS) in its proteoglycan form.	Chondroitin Sulfates	80-99	transforming growth factor beta 2	Homo sapiens	52-61
34299163-2	2021	In a recent study, we found that preterm human milk TGF-beta2 is sequestered by chondroitin sulfate (CS) in its proteoglycan form.	Chondroitin Sulfates	101-103	transforming growth factor beta 2	Homo sapiens	52-61
34299163-5	2021	This library of 1752 CS oligosaccharides was first screened against TGF-beta2 using the dual filter CVLS algorithm in which the GOLDScore and root-mean-square-difference (RMSD) between the best bound poses were used as surrogate markers for in silico affinity and in silico specificity.	Chondroitin Sulfates	21-23	transforming growth factor beta 2	Homo sapiens	68-77
34299163-10	2021	More specifically, the highly selective CS chains were found to engage the TGF-beta2 monomer with high affinity.	Chondroitin Sulfates	40-42	transforming growth factor beta 2	Homo sapiens	75-84
34299163-13	2021	Finally, the study led to the identification of unique CS sequences that are predicted to selectively recognize TGF-beta2 and may out-compete common natural CS biopolymers.	Chondroitin Sulfates	55-57	transforming growth factor beta 2	Homo sapiens	112-121
34252115-1	2021	OBJECTIVE: To test the hypothesis that the use of chondroitin sulfate (CS) or glucosamine reduces the risk of acute myocardial infarction (AMI).	Chondroitin Sulfates	50-69	citrate synthase	Homo sapiens	71-73
34703499-4	2021	Due to the dual effect of BSA and CS, BC-DOX-NPs interacted with the gp60, SPARC and CD44 receptors on tumor cells, facilitating their rapid and efficient transcytosis and improving their accumulation and uptake within tumor tissues.	Chondroitin Sulfates	34-36	secreted acidic cysteine rich glycoprotein	Mus musculus	75-80
34703499-4	2021	Due to the dual effect of BSA and CS, BC-DOX-NPs interacted with the gp60, SPARC and CD44 receptors on tumor cells, facilitating their rapid and efficient transcytosis and improving their accumulation and uptake within tumor tissues.	Chondroitin Sulfates	34-36	CD44 antigen	Mus musculus	85-89
34703499-5	2021	The simultaneous presence of BSA and CS also allowed BC-DOX-NPs to target CD44 efficiently, leading to greater cellular uptake and cytotoxicity against 4T1 cells than CS-DOX-NPs or free DOX.	Chondroitin Sulfates	37-39	CD44 antigen	Mus musculus	74-78
34703499-5	2021	The simultaneous presence of BSA and CS also allowed BC-DOX-NPs to target CD44 efficiently, leading to greater cellular uptake and cytotoxicity against 4T1 cells than CS-DOX-NPs or free DOX.	Chondroitin Sulfates	167-169	CD44 antigen	Mus musculus	74-78
34209670-4	2021	However, existing chemical inhibition methods for HS also interfere with chondroitin sulphate (CS), complicating data interpretation of HS function.	Chondroitin Sulfates	73-93	citrate synthase	Homo sapiens	95-97
34221961-7	2021	VCAN encodes a large chondroitin sulfate proteoglycan that is the main component of the extracellular matrix, and PDGFRB encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor (PDGF) family.	Chondroitin Sulfates	21-40	versican	Homo sapiens	0-4
34214381-15	2021	RESULTS: There were significant differences in the increase of TGF-beta, the number of osteoblasts and callus compressive strength in the groups with chondroitin sulfate treatment for 2 and 4 weeks, compared to the control group (p<0.01).	Chondroitin Sulfates	150-169	transforming growth factor alpha	Rattus norvegicus	63-71
34214381-16	2021	CONCLUSIONS: Administering chondroitin sulfate in a dose of 7 mg in 2 mL distilled water for 2 and 4 weeks may increase production of TGF-beta, the osteoblast numbers and the callus compressive strength in fracture healing.	Chondroitin Sulfates	27-46	transforming growth factor alpha	Rattus norvegicus	134-142
34145250-2	2021	Two C. difficile exotoxins (TcdA and TcdB) are major virulence factors associated with these infections, and chondroitin sulfate proteoglycan 4 (CSPG4) is a potential receptor for TcdB, but its pathophysiological relevance and the molecular details that govern recognition remain unknown.	Chondroitin Sulfates	109-128	chondroitin sulfate proteoglycan 4	Mus musculus	145-150
34105546-1	2021	The first vibrational sum-frequency generation (VSFG) spectra of chondroitin sulfate (CS) interacting with dipalmitoyl phosphatidylcholine (DPPC) at air-liquid interface are reported here, collected at a laser repetition rate of 100 kHz.	Chondroitin Sulfates	65-84	citrate synthase	Homo sapiens	86-88
34222264-5	2021	Recent reports have demonstrated that chondroitin sulfate and heparan sulfate, both of which are glycosaminoglycans, work as physiological ligands on their shared receptor, protein tyrosine phosphatase sigma (PTPsigma).	Chondroitin Sulfates	38-57	protein tyrosine phosphatase receptor type S	Homo sapiens	209-217
34222264-8	2021	In our recent study, we demonstrated that the chondroitin sulfate (CS)-PTPsigma axis disrupted autophagy flux at the axon tips by dephosphorylating cortactin.	Chondroitin Sulfates	46-65	protein tyrosine phosphatase receptor type S	Homo sapiens	71-79
34222264-8	2021	In our recent study, we demonstrated that the chondroitin sulfate (CS)-PTPsigma axis disrupted autophagy flux at the axon tips by dephosphorylating cortactin.	Chondroitin Sulfates	46-65	cortactin	Homo sapiens	148-157
34222264-8	2021	In our recent study, we demonstrated that the chondroitin sulfate (CS)-PTPsigma axis disrupted autophagy flux at the axon tips by dephosphorylating cortactin.	Chondroitin Sulfates	67-69	protein tyrosine phosphatase receptor type S	Homo sapiens	71-79
34222264-8	2021	In our recent study, we demonstrated that the chondroitin sulfate (CS)-PTPsigma axis disrupted autophagy flux at the axon tips by dephosphorylating cortactin.	Chondroitin Sulfates	67-69	cortactin	Homo sapiens	148-157
34169071-2	2021	The chondroitin sulfate proteoglycan (CSPG) DSD-1-PG is an isoform of receptor protein tyrosine phosphatase-beta/zeta (RPTPbeta/zeta), a trans-membrane receptor expressed by NSPCs.	Chondroitin Sulfates	4-23	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	44-52
34225875-3	2021	In this study, chondroitin sulfate (CS) E oligosaccharides were prepared and we identified disaccharide as the functional unit showing the strongest anti-complement activity and screened out complement C5 as its target in the complement system.	Chondroitin Sulfates	15-34	complement C5	Homo sapiens	191-204
34225875-3	2021	In this study, chondroitin sulfate (CS) E oligosaccharides were prepared and we identified disaccharide as the functional unit showing the strongest anti-complement activity and screened out complement C5 as its target in the complement system.	Chondroitin Sulfates	36-38	complement C5	Homo sapiens	191-204
34200496-1	2021	Mucopolysaccharidosis type IVA (MPS IVA) is a lysosomal disease caused by mutations in the gene encoding the enzymeN-acetylgalactosamine-6-sulfate sulfatase (GALNS), and is characterized by systemic skeletal dysplasia due to excessive storage of keratan sulfate (KS) and chondroitin-6-sulfate in chondrocytes.	Chondroitin Sulfates	271-292	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	158-163
34169071-2	2021	The chondroitin sulfate proteoglycan (CSPG) DSD-1-PG is an isoform of receptor protein tyrosine phosphatase-beta/zeta (RPTPbeta/zeta), a trans-membrane receptor expressed by NSPCs.	Chondroitin Sulfates	4-23	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	119-127
35552694-3	2022	In the biosynthesis of CS/DS containing GalNAc4S6S, three groups of sulfotransferases are involved; chondroitin 4-sulfotransferases (C4STs), dermatan 4-sulfotransferase-1 (D4ST-1) and GalNAc 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST).	Chondroitin Sulfates	23-25	carbohydrate sulfotransferase 14	Homo sapiens	141-170
34073798-4	2021	For example, PTPsigma, a member of type IIa RPTPs, on axon terminals is monomerized and activated by the extracellular CS deposited in neural injuries, dephosphorylates cortactin, disrupts autophagy flux, and consequently inhibits axon regeneration.	Chondroitin Sulfates	119-121	protein tyrosine phosphatase receptor type S	Homo sapiens	13-21
34073798-4	2021	For example, PTPsigma, a member of type IIa RPTPs, on axon terminals is monomerized and activated by the extracellular CS deposited in neural injuries, dephosphorylates cortactin, disrupts autophagy flux, and consequently inhibits axon regeneration.	Chondroitin Sulfates	119-121	cortactin	Homo sapiens	169-178
34337507-2	2021	Hyaluronic acid (HA) and chondroitin sulfate (CS) are components of the urothelial mucosa and positive results have been obtained for intravesical HA/CS instillations for the treatment of urinary tract infections and bladder pain syndrome.	Chondroitin Sulfates	25-44	citrate synthase	Homo sapiens	46-48
34337507-2	2021	Hyaluronic acid (HA) and chondroitin sulfate (CS) are components of the urothelial mucosa and positive results have been obtained for intravesical HA/CS instillations for the treatment of urinary tract infections and bladder pain syndrome.	Chondroitin Sulfates	25-44	citrate synthase	Homo sapiens	150-152
35390446-2	2022	CHSY1, one of the glycosyltransferases, is involved in the synthesis of chondroitin sulfate.	Chondroitin Sulfates	72-91	chondroitin sulfate synthase 1	Rattus norvegicus	0-5
35134274-2	2022	We describe here, a novel tri-layered scaffold-with a top layer containing type II atelocollagen and chondroitin sulphate for cartilage regeneration, an intermediate layer with type II atelocollagen and hydroxyapatite for calcified cartilage formation, and a bottom layer with type I atelocollagen and hydroxyapatite for bone growth-that can be built using liquid-phase co-synthesis.	Chondroitin Sulfates	101-121	tRNA-Ile (anticodon AAT) 9-1	Homo sapiens	26-29
35495590-6	2022	In addition, western blot analysis revealed that myelin basic protein (MBP) and chondroitin sulphate proteoglycan 4 (NG2) expression levels were significantly decreased in MK-801-induced mice, while the expression of G protein-coupled receptor 17 (GPR17) was increased.	Chondroitin Sulfates	80-100	chondroitin sulfate proteoglycan 4	Mus musculus	117-120
35495590-6	2022	In addition, western blot analysis revealed that myelin basic protein (MBP) and chondroitin sulphate proteoglycan 4 (NG2) expression levels were significantly decreased in MK-801-induced mice, while the expression of G protein-coupled receptor 17 (GPR17) was increased.	Chondroitin Sulfates	80-100	G protein-coupled receptor 17	Mus musculus	217-246
35614038-0	2022	Chondroitin sulfate proteoglycans prevent immune cell phenotypic conversion and inflammation resolution via TLR4 in rodent models of spinal cord injury.	Chondroitin Sulfates	0-19	toll like receptor 4	Homo sapiens	108-112
34337507-16	2021	Patient summary: We investigated whether hyaluronic acid (HA) and chondroitin sulfate (CS) have a protective effect against the bladder toxicity of radiotherapy for prostate cancer.	Chondroitin Sulfates	66-85	citrate synthase	Homo sapiens	87-89
35513096-0	2022	N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis.	Chondroitin Sulfates	28-47	CD44 molecule (Indian blood group)	Homo sapiens	137-141
35513096-5	2022	Meanwhile, recent studies related to Chondroitin sulfate have excellent target binding ability with CD44 receptor.	Chondroitin Sulfates	37-56	CD44 molecule (Indian blood group)	Homo sapiens	100-104
35513096-10	2022	Then, micelles with N-Acetylneuraminic acid and Chondroitin sulfate were prepared to load rapamycin(RAP).	Chondroitin Sulfates	48-67	LDL receptor related protein associated protein 1	Homo sapiens	100-103
35063851-1	2022	In this study, the fucoxanthin (FUC)-loaded gliadin nanoparticles (Gli NPs) stabilized by chondroitin sulfate (ChS) were fabricated.	Chondroitin Sulfates	90-109	GLI family zinc finger 1	Homo sapiens	67-70
35063851-1	2022	In this study, the fucoxanthin (FUC)-loaded gliadin nanoparticles (Gli NPs) stabilized by chondroitin sulfate (ChS) were fabricated.	Chondroitin Sulfates	111-114	GLI family zinc finger 1	Homo sapiens	67-70
35601064-0	2022	mTORC1 is a key regulator that mediates OGD- and TGFbeta1-induced myofibroblast transformation and chondroitin-4-sulfate expression in cardiac fibroblasts.	Chondroitin Sulfates	99-120	CREB regulated transcription coactivator 1	Mus musculus	0-6
35601064-0	2022	mTORC1 is a key regulator that mediates OGD- and TGFbeta1-induced myofibroblast transformation and chondroitin-4-sulfate expression in cardiac fibroblasts.	Chondroitin Sulfates	99-120	transforming growth factor beta 1	Homo sapiens	49-57
35601064-5	2022	The present study found that oxygen-glucose deprivation (OGD) and TGFbeta1 stimulation induced myofibroblast transformation and C4S synthesis in vitro by using reverse transcription-quantitative PCR, western blotting and immunofluorescence.	Chondroitin Sulfates	128-131	transforming growth factor beta 1	Homo sapiens	66-74
35601064-7	2022	Using the PI3K inhibitor ZSTK474, the Akt inhibitor MK2206, or the mTOR inhibitor AZD8055, it was observed that OGD and TGFbeta1 stimulation induced myofibroblast transformation and that C4S synthesis was mTOR-dependent, whereas the upstream canonical PI3K/Akt axis was dispensable by using western blotting and immunofluorescence.	Chondroitin Sulfates	187-190	mechanistic target of rapamycin kinase	Homo sapiens	67-71
35601064-7	2022	Using the PI3K inhibitor ZSTK474, the Akt inhibitor MK2206, or the mTOR inhibitor AZD8055, it was observed that OGD and TGFbeta1 stimulation induced myofibroblast transformation and that C4S synthesis was mTOR-dependent, whereas the upstream canonical PI3K/Akt axis was dispensable by using western blotting and immunofluorescence.	Chondroitin Sulfates	187-190	transforming growth factor beta 1	Homo sapiens	120-128
35420777-1	2022	Heparan sulfate (HS) and chondroitin sulfate (CS) are two structurally distinct natural polysaccharides.	Chondroitin Sulfates	25-44	citrate synthase	Homo sapiens	46-48
35588467-1	2022	OBJECTIVE: To evaluate the efficacy of chondroitin sulfate (CS) and glucosamine (GS), the most relevant drugs of "Symptomatic Slow Acting Drug for Osteoarthritis" (SYSADOA), in the functional and symptomatic improvement of temporomandibular dysfunction.	Chondroitin Sulfates	39-58	citrate synthase	Homo sapiens	60-62
35552402-7	2022	Hyperglycemia significantly increased the shedding of heparan sulfate (HS), chondroitin sulfate (CS), and hyaluronic acid (HA).	Chondroitin Sulfates	76-95	citrate synthase	Rattus norvegicus	97-99
35552694-3	2022	In the biosynthesis of CS/DS containing GalNAc4S6S, three groups of sulfotransferases are involved; chondroitin 4-sulfotransferases (C4STs), dermatan 4-sulfotransferase-1 (D4ST-1) and GalNAc 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST).	Chondroitin Sulfates	23-25	carbohydrate sulfotransferase 14	Homo sapiens	172-178
35552694-3	2022	In the biosynthesis of CS/DS containing GalNAc4S6S, three groups of sulfotransferases are involved; chondroitin 4-sulfotransferases (C4STs), dermatan 4-sulfotransferase-1 (D4ST-1) and GalNAc 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST).	Chondroitin Sulfates	23-25	carbohydrate sulfotransferase 15	Homo sapiens	184-221
35552694-3	2022	In the biosynthesis of CS/DS containing GalNAc4S6S, three groups of sulfotransferases are involved; chondroitin 4-sulfotransferases (C4STs), dermatan 4-sulfotransferase-1 (D4ST-1) and GalNAc 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST).	Chondroitin Sulfates	23-25	carbohydrate sulfotransferase 15	Homo sapiens	223-235
35466985-8	2022	Moreover, CS coating promoted selective accumulation in CD44-overexpressing HepG2 cells, resulting in higher inhibition of tumor growth compared to free Cur and FP-NaCas NP-encapsulated Cur.	Chondroitin Sulfates	10-12	CD44 molecule (Indian blood group)	Homo sapiens	56-60
35574049-4	2023	In this study, a regenerative scaffold regulating the macrophage immune microenvironment and promoting bone regeneration in a dual-stage process for the postoperative treatment of bone tumors was constructed by binding a colony-stimulating factor 1 receptor (CSF-1R) inhibitor GW2580 onto in situ cosslinked hydroxybutylchitosan (HBC)/oxidized chondroitin sulfate (OCS) hydrogel layer covering a 3D printed calcium phosphate scaffold based on electrostatic interaction.	Chondroitin Sulfates	344-363	colony stimulating factor 1 receptor	Homo sapiens	221-257
35574049-4	2023	In this study, a regenerative scaffold regulating the macrophage immune microenvironment and promoting bone regeneration in a dual-stage process for the postoperative treatment of bone tumors was constructed by binding a colony-stimulating factor 1 receptor (CSF-1R) inhibitor GW2580 onto in situ cosslinked hydroxybutylchitosan (HBC)/oxidized chondroitin sulfate (OCS) hydrogel layer covering a 3D printed calcium phosphate scaffold based on electrostatic interaction.	Chondroitin Sulfates	344-363	colony stimulating factor 1 receptor	Homo sapiens	259-265
35501796-5	2022	Due to the high expression of CD44 receptor on the surface of tumor cells, we encapsulated chondroitin sulfate gel shell (CS-shell) with CD44 targeting and apoptosis promoting effect on the surface of DOX@MOF-COD nanoparticles, which can accurately and efficiently deliver the drugs to the tumor site and improve the effect of reversing drug resistance.	Chondroitin Sulfates	91-110	CD44 molecule (Indian blood group)	Homo sapiens	30-34
35501796-5	2022	Due to the high expression of CD44 receptor on the surface of tumor cells, we encapsulated chondroitin sulfate gel shell (CS-shell) with CD44 targeting and apoptosis promoting effect on the surface of DOX@MOF-COD nanoparticles, which can accurately and efficiently deliver the drugs to the tumor site and improve the effect of reversing drug resistance.	Chondroitin Sulfates	91-110	CD44 molecule (Indian blood group)	Homo sapiens	137-141
35501796-5	2022	Due to the high expression of CD44 receptor on the surface of tumor cells, we encapsulated chondroitin sulfate gel shell (CS-shell) with CD44 targeting and apoptosis promoting effect on the surface of DOX@MOF-COD nanoparticles, which can accurately and efficiently deliver the drugs to the tumor site and improve the effect of reversing drug resistance.	Chondroitin Sulfates	91-110	lysine acetyltransferase 8	Homo sapiens	205-208
34558535-10	2022	Taken together, our results suggest that microglia undergo M1 polarization and express high levels of TGFbeta1 at 3 and 7 dpi, and that M1-type microglia induce astrocytes to deposit chondroitin sulfate proteoglycan via the TGFbeta1/SOX9 pathway.	Chondroitin Sulfates	183-202	transforming growth factor beta 1	Homo sapiens	224-232
35385326-1	2022	Aggrecan (Acan) and versican (Vcan) are large chondroitin sulfate proteoglycans of the extracellular matrix.	Chondroitin Sulfates	46-65	aggrecan	Homo sapiens	10-14
35385326-1	2022	Aggrecan (Acan) and versican (Vcan) are large chondroitin sulfate proteoglycans of the extracellular matrix.	Chondroitin Sulfates	46-65	versican	Homo sapiens	20-28
35385326-1	2022	Aggrecan (Acan) and versican (Vcan) are large chondroitin sulfate proteoglycans of the extracellular matrix.	Chondroitin Sulfates	46-65	versican	Homo sapiens	30-34
34558535-10	2022	Taken together, our results suggest that microglia undergo M1 polarization and express high levels of TGFbeta1 at 3 and 7 dpi, and that M1-type microglia induce astrocytes to deposit chondroitin sulfate proteoglycan via the TGFbeta1/SOX9 pathway.	Chondroitin Sulfates	183-202	SRY-box transcription factor 9	Homo sapiens	233-237
35621559-2	2022	Herein, gelatin-based hydrogels were designed and loaded with chondroitin sulfate (CS) to endow biological regulation on the angiogenesis behaviors of endothelial cells (ECs).	Chondroitin Sulfates	62-81	citrate synthase	Homo sapiens	83-85
35631323-1	2022	Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo.	Chondroitin Sulfates	0-19	pleiotrophin	Homo sapiens	53-65
35631323-1	2022	Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo.	Chondroitin Sulfates	0-19	pleiotrophin	Homo sapiens	67-70
35631323-1	2022	Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo.	Chondroitin Sulfates	21-23	pleiotrophin	Homo sapiens	53-65
35631323-1	2022	Chondroitin sulfate (CS) E is the natural ligand for pleiotrophin (PTN) in the central nervous system (CNS) of the embryo.	Chondroitin Sulfates	21-23	pleiotrophin	Homo sapiens	67-70
35431911-4	2021	The CD44 receptor has a selective binding affinity towards hyaluronic and chondroitin sulfate (CS).	Chondroitin Sulfates	74-93	citrate synthase	Homo sapiens	95-97
35173094-0	2022	Chondroitin sulfate E downregulates N-cadherin and suppresses myotube formation.	Chondroitin Sulfates	0-19	cadherin 2	Homo sapiens	36-46
35173094-6	2022	These results suggest that N-cadherin downregulation is one of the mechanisms underlying the CS-E-induced suppression of myotube formation.	Chondroitin Sulfates	93-96	cadherin 2	Homo sapiens	27-37
35067724-6	2022	In fully developed molars, CS was restricted to the root apex region colocalizing with Gli1-positive cells.	Chondroitin Sulfates	27-29	GLI-Kruppel family member GLI1	Mus musculus	87-91
35067724-7	2022	In the healing process after tooth replantation, CD31-positive cells accumulated in the CS-positive stroma in WT molars.	Chondroitin Sulfates	88-90	platelet/endothelial cell adhesion molecule 1	Mus musculus	49-53
35067724-9	2022	In primary culture experiments, siRNA knockdown of T1 gene significantly suppressed cell proliferation in WT dental pulp cells, and the mRNA expression of cyclin D1 and CD31 was significantly upregulated by external CS in T1KO dental pulp cells.	Chondroitin Sulfates	216-218	cyclin D1	Mus musculus	155-164
35067724-9	2022	In primary culture experiments, siRNA knockdown of T1 gene significantly suppressed cell proliferation in WT dental pulp cells, and the mRNA expression of cyclin D1 and CD31 was significantly upregulated by external CS in T1KO dental pulp cells.	Chondroitin Sulfates	216-218	platelet/endothelial cell adhesion molecule 1	Mus musculus	169-173
35312866-1	2022	Synthesis of glycosaminoglycans, such as heparan sulfate (HS) and chondroitin sulfate (CS), occurs in the lumen of the Golgi, but the relationship between Golgi structural integrity and glycosaminoglycan synthesis is not clear.	Chondroitin Sulfates	66-85	citrate synthase	Homo sapiens	87-89
35372047-2	2022	Chondroitin Polymerizing Factor (CHPF), is an enzyme involved in chondroitin sulfate (CS) elongation and a novel key molecule in the poor prognosis of many cancers.	Chondroitin Sulfates	65-84	chondroitin polymerizing factor	Homo sapiens	0-31
35372047-2	2022	Chondroitin Polymerizing Factor (CHPF), is an enzyme involved in chondroitin sulfate (CS) elongation and a novel key molecule in the poor prognosis of many cancers.	Chondroitin Sulfates	65-84	chondroitin polymerizing factor	Homo sapiens	33-37
35372047-2	2022	Chondroitin Polymerizing Factor (CHPF), is an enzyme involved in chondroitin sulfate (CS) elongation and a novel key molecule in the poor prognosis of many cancers.	Chondroitin Sulfates	86-88	chondroitin polymerizing factor	Homo sapiens	0-31
35372047-2	2022	Chondroitin Polymerizing Factor (CHPF), is an enzyme involved in chondroitin sulfate (CS) elongation and a novel key molecule in the poor prognosis of many cancers.	Chondroitin Sulfates	86-88	chondroitin polymerizing factor	Homo sapiens	33-37
35290467-3	2022	Pregnant Aotus infected with CSA-binding Pf-CS2 parasites during 3rd trimester developed pronounced sequestration of late-stage parasites in placental intervillous spaces that express VAR2CSA and bind specifically to CSA.	Chondroitin Sulfates	29-32	chorionic somatomammotropin hormone 2	Homo sapiens	44-47
35290467-3	2022	Pregnant Aotus infected with CSA-binding Pf-CS2 parasites during 3rd trimester developed pronounced sequestration of late-stage parasites in placental intervillous spaces that express VAR2CSA and bind specifically to CSA.	Chondroitin Sulfates	217-220	chorionic somatomammotropin hormone 2	Homo sapiens	44-47
35133126-1	2022	Adding chondroitin sulfate (CS) to collagen scaffolds has been shown to improve the outcomes for articular cartilage tissue engineering.	Chondroitin Sulfates	7-26	citrate synthase	Homo sapiens	28-30
35195399-4	2022	In this study, we investigated the fabrication of chondroitin sulfate/hyaluronic acid (CS/HA)-based DN hydrogels, in which two networks are interpenetrated and cross-linked with the dynamic covalent bonds of very different lifetimes.	Chondroitin Sulfates	50-69	citrate synthase	Homo sapiens	87-89
35176450-1	2022	Versican is a large chondroitin sulfate/dermatan sulfate proteoglycan that plays a key role in the formation of the provisional matrix.	Chondroitin Sulfates	20-39	versican	Mus musculus	0-8
35053232-2	2022	Its wide expression in human tissues compared to the other component of group 5 of receptor phosphatases, PTPRZ expressed as a chondroitin sulfate proteoglycan in the central nervous system, has raised interest in its role as a possible regulatory switch of cell signaling processes.	Chondroitin Sulfates	127-146	protein tyrosine phosphatase receptor type Z1	Homo sapiens	106-111
35433786-3	2022	In this study, we used animal experiments to show that oral chondroitin sulfate (CS), cartilage powder, and type II collagen peptides could increase the athletic ability of rats and reduce inflammatory cytokine levels in serum or synovial fluid, including prostaglandin E2, tumor necrosis factor-alpha, interleukin (IL) 1beta, IL-6, and IL-17.	Chondroitin Sulfates	60-79	citrate synthase	Rattus norvegicus	81-83
35433786-3	2022	In this study, we used animal experiments to show that oral chondroitin sulfate (CS), cartilage powder, and type II collagen peptides could increase the athletic ability of rats and reduce inflammatory cytokine levels in serum or synovial fluid, including prostaglandin E2, tumor necrosis factor-alpha, interleukin (IL) 1beta, IL-6, and IL-17.	Chondroitin Sulfates	60-79	dihydrolipoamide S-succinyltransferase	Rattus norvegicus	270-301
35433786-3	2022	In this study, we used animal experiments to show that oral chondroitin sulfate (CS), cartilage powder, and type II collagen peptides could increase the athletic ability of rats and reduce inflammatory cytokine levels in serum or synovial fluid, including prostaglandin E2, tumor necrosis factor-alpha, interleukin (IL) 1beta, IL-6, and IL-17.	Chondroitin Sulfates	60-79	interleukin 1 alpha	Rattus norvegicus	303-325
35433786-3	2022	In this study, we used animal experiments to show that oral chondroitin sulfate (CS), cartilage powder, and type II collagen peptides could increase the athletic ability of rats and reduce inflammatory cytokine levels in serum or synovial fluid, including prostaglandin E2, tumor necrosis factor-alpha, interleukin (IL) 1beta, IL-6, and IL-17.	Chondroitin Sulfates	60-79	interleukin 6	Rattus norvegicus	327-331
35433786-3	2022	In this study, we used animal experiments to show that oral chondroitin sulfate (CS), cartilage powder, and type II collagen peptides could increase the athletic ability of rats and reduce inflammatory cytokine levels in serum or synovial fluid, including prostaglandin E2, tumor necrosis factor-alpha, interleukin (IL) 1beta, IL-6, and IL-17.	Chondroitin Sulfates	60-79	interleukin 17A	Rattus norvegicus	337-342
35242620-1	2022	Chondroitin sulfate (CS) is a glycosaminoglycan with a broad range of applications being a popular dietary supplement for osteoarthritis.	Chondroitin Sulfates	0-19	citrate synthase	Homo sapiens	21-23
35163920-3	2022	Studies have highlighted the action of chondroitin sulfate (CS) in different cells; thus, our aim was to analyze its effect on an experimental model of bile duct ligation (BDL).	Chondroitin Sulfates	39-58	citrate synthase	Rattus norvegicus	60-62
34901972-7	2022	As expected, this novel CS-loaded MOF demonstrated an excellent antifouling performance in various biological samples, even in 100% goat serum.	Chondroitin Sulfates	24-26	lysine acetyltransferase 8	Homo sapiens	34-37
35297475-0	2022	Chondroitin Sulfate Enhances Proliferation and Migration via Inducing beta-Catenin and Intracellular ROS as Well as Suppressing Metalloproteinases through Akt/NF-kappaB Pathway Inhibition in Human Chondrocytes.	Chondroitin Sulfates	0-19	catenin beta 1	Homo sapiens	70-82
35182063-2	2022	PCL alongside proteins and polysaccharides, like gelatin (GEL) and chondroitin sulphate (CS), can be used to fabricate composite scaffolds that provide mechanical and biological requirements for skin tissue engineering scaffolds.	Chondroitin Sulfates	67-87	citrate synthase	Homo sapiens	89-91
35297475-0	2022	Chondroitin Sulfate Enhances Proliferation and Migration via Inducing beta-Catenin and Intracellular ROS as Well as Suppressing Metalloproteinases through Akt/NF-kappaB Pathway Inhibition in Human Chondrocytes.	Chondroitin Sulfates	0-19	AKT serine/threonine kinase 1	Homo sapiens	155-158
35297475-0	2022	Chondroitin Sulfate Enhances Proliferation and Migration via Inducing beta-Catenin and Intracellular ROS as Well as Suppressing Metalloproteinases through Akt/NF-kappaB Pathway Inhibition in Human Chondrocytes.	Chondroitin Sulfates	0-19	nuclear factor kappa B subunit 1	Homo sapiens	159-168
35297475-1	2022	BACKGROUND: Chondroitin sulfate (CS) is found in humans" cartilage, bone, cornea, skin, and arterial wall.	Chondroitin Sulfates	12-31	citrate synthase	Homo sapiens	33-35
2512987-3	1989	In this study we assayed in rats the DAO-releasing capability of heparan sulphate, dermatan sulphate, chondroitin sulphate A and hyaluronic acid, all heparin related compounds.	Chondroitin Sulfates	102-124	amine oxidase, copper containing 1	Rattus norvegicus	37-40
34626407-1	2022	Versican is a widely distributed chondroitin sulfate proteoglycan that forms large complexes with the glycosaminoglycan hyaluronan (HA).	Chondroitin Sulfates	33-52	versican	Homo sapiens	0-8
34626417-3	2022	The HABP probe is prepared by enzymatic digestion of the chondroitin sulfate proteoglycan aggrecan which is present in bovine nasal cartilage and is then biotinylated in the presence of bound hyaluronan and the link protein.	Chondroitin Sulfates	57-76	hyaluronan binding protein 2	Homo sapiens	4-8
2533389-3	1989	Interaction of tetranectin with chondroitin sulphate A, B, and C, heparan sulphate and trypan blue could be demonstrated by crossed immunoelectrophoresis against monospecific rabbit anti-tetranectin.	Chondroitin Sulfates	32-52	C-type lectin domain family 3 member B	Homo sapiens	15-26
2509263-3	1989	Beads coated with heparin, chondroitin sulfate, or poly L-lysine, that were mixed with limb bud mesenchymal cells were centripetally conveyed into fibronectin-rich regions of cell condensation over a period of several days.	Chondroitin Sulfates	27-46	fibronectin 1	Homo sapiens	147-158
2509487-1	1989	Cultured monolayers of NMuMG mouse mammary epithelial cells have augmented amounts of cell surface chondroitin sulfate glycosaminoglycan (GAG) when cultured in transforming growth factor-beta (TGF-beta), presumably because of increased synthesis on their cell surface proteoglycan (named syndecan), previously shown to contain chondroitin sulfate and heparan sulfate GAG.	Chondroitin Sulfates	99-118	transforming growth factor, beta 1	Mus musculus	193-201
2509487-4	1989	Characterization of purified syndecan confirms the enhanced addition of chondroitin sulfate in TGF-beta: (a) radiosulfate incorporation into chondroitin sulfate is increased 6.2-fold in this proteoglycan fraction and heparan sulfate is increased 1.8-fold, despite no apparent increase in amount of core protein per cell, and (b) the size and density of the proteoglycan are increased, but reduced by removal of chondroitin sulfate.	Chondroitin Sulfates	72-91	transforming growth factor, beta 1	Mus musculus	95-103
2509487-4	1989	Characterization of purified syndecan confirms the enhanced addition of chondroitin sulfate in TGF-beta: (a) radiosulfate incorporation into chondroitin sulfate is increased 6.2-fold in this proteoglycan fraction and heparan sulfate is increased 1.8-fold, despite no apparent increase in amount of core protein per cell, and (b) the size and density of the proteoglycan are increased, but reduced by removal of chondroitin sulfate.	Chondroitin Sulfates	141-160	transforming growth factor, beta 1	Mus musculus	95-103
2509487-4	1989	Characterization of purified syndecan confirms the enhanced addition of chondroitin sulfate in TGF-beta: (a) radiosulfate incorporation into chondroitin sulfate is increased 6.2-fold in this proteoglycan fraction and heparan sulfate is increased 1.8-fold, despite no apparent increase in amount of core protein per cell, and (b) the size and density of the proteoglycan are increased, but reduced by removal of chondroitin sulfate.	Chondroitin Sulfates	141-160	transforming growth factor, beta 1	Mus musculus	95-103
2509487-9	1989	One of the effects of TGF-beta during embryonic tissue interactions is likely to be the enhanced synthesis of chondroitin sulfate chains on this cell surface proteoglycan.	Chondroitin Sulfates	110-129	transforming growth factor, beta 1	Mus musculus	22-30
2509244-0	1989	Transforming growth factors (TGF alpha and TGF beta 1) stimulate chondroitin sulfate and hyaluronate synthesis in cultured rat liver fat storing cells.	Chondroitin Sulfates	65-84	transforming growth factor alpha	Rattus norvegicus	29-38
2509244-0	1989	Transforming growth factors (TGF alpha and TGF beta 1) stimulate chondroitin sulfate and hyaluronate synthesis in cultured rat liver fat storing cells.	Chondroitin Sulfates	65-84	transforming growth factor, beta 1	Rattus norvegicus	43-53
2533389-3	1989	Interaction of tetranectin with chondroitin sulphate A, B, and C, heparan sulphate and trypan blue could be demonstrated by crossed immunoelectrophoresis against monospecific rabbit anti-tetranectin.	Chondroitin Sulfates	32-52	C-type lectin domain family 3 member B	Homo sapiens	187-198
2528543-2	1989	The C-terminal portion of the deduced amino acid sequence is homologous to the chondroitin sulfate-rich region (domain CS1) of the rat chondrosarcoma proteoglycan, and the N-terminal portion is homologous to the second globular domain (G2) of the rat proteoglycan (Doege, K., Sasaki, M., Horigan, E., Hassell, J. R., and Yamada, Y.	Chondroitin Sulfates	79-98	catalase	Rattus norvegicus	119-122
2479114-1	1989	Influence of heparin, chondroitin sulfate C and dextran sulfate (MW 3,500 and 7,000) on plasmin catalyzed conversion of single-chain (scu-PA) to two-chain (u-PA) urokinase-type plasminogen activator and generation of plasmin in mixtures of scu-PA and Glu-plasminogen (Glu-plg) was investigated.	Chondroitin Sulfates	22-43	plasminogen	Homo sapiens	88-95
2479114-2	1989	Conversion of scu-PA to u-PA catalyzed by plasmin was enhanced by chondroitin sulfate C and heparin, maximally by 10-fold and 3-fold, respectively.	Chondroitin Sulfates	66-87	plasminogen activator, urokinase	Homo sapiens	16-20
2479114-2	1989	Conversion of scu-PA to u-PA catalyzed by plasmin was enhanced by chondroitin sulfate C and heparin, maximally by 10-fold and 3-fold, respectively.	Chondroitin Sulfates	66-87	plasminogen	Homo sapiens	42-49
2722809-6	1989	The uniqueness of the cell-HABP-associated protein kinase activity was suggested by both its specific response to hyaluronate, relative to related glycosaminoglycans such as heparin and chondroitin sulfate or to growth factors such as epidermal growth factor or insulin, and its antigenic distinction from other protein kinases such as growth factor receptors.	Chondroitin Sulfates	186-205	insulin	Gallus gallus	262-269
2505639-4	1989	In addition, chondroitin sulfates and heparan sulfate are identified either by prior digestion with chondroitin ABC or AC lyase, as generated disaccharides fail to bind to the blot, or by treatment of the entire blot with nitrous acid following binding.	Chondroitin Sulfates	13-33	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	112-115
2809592-6	1989	Binding of N-CAM 110 to collagens could be prevented in a concentration-dependent manner by the glycosaminoglycans heparin and chondroitin sulfate.	Chondroitin Sulfates	127-146	neural cell adhesion molecule 1	Homo sapiens	11-16
2809592-7	1989	N-CAM 110 also interacted with immobilized heparin, and this interaction could be prevented by heparin and chondroitin sulfate.	Chondroitin Sulfates	107-126	neural cell adhesion molecule 1	Homo sapiens	0-5
2666417-7	1989	The chondroitin sulfate chains contained exclusively chondroitin 4- and 6-sulfate; however, the ratio of these two disaccharides differed between the medium- and cell-associated proteoglycans, and changed during progression of the cells into a fully differentiated phenotype.	Chondroitin Sulfates	4-23	carbohydrate sulfotransferase 11	Mus musculus	53-66
2916650-4	1989	The present study examined the tissue distribution of three prototype melanoma cell surface antigens, the Mr 57,000 glycoprotein (gp57) recognized by MAb A42, the GD3 ganglioside, and the mel-CSPG chondroitin sulfate proteoglycan.	Chondroitin Sulfates	197-216	chondroitin sulfate proteoglycan 4	Homo sapiens	188-196
2470739-9	1989	In contrast, heparan sulfate proteoglycan form LD and heparan sulfate-derivatized serum albumin had far lower inhibitory activities, indicating that the active site for the interaction between cells and PG-M is on the chondroitin sulfate chains.	Chondroitin Sulfates	218-237	versican	Gallus gallus	203-207
2646937-3	1989	Monoclonal antibodies (MAb) 3-B-3, 9-A-2, or 2-B-6 and 5-D-4, recognizing delta Di-6S generated from chondroitin 6-sulfate (C6S) PG; delta Di-4S generated from dermatan sulfate (DS) PG and from chondroitin 4-sulfate (C4S); and sulfated poly N-acetyllactosamine sequences common to keratan sulfate (KS), respectively, were used to localize PG types by indirect immunofluorescence.	Chondroitin Sulfates	101-122	olfactory receptor family 2 subfamily B member 6	Homo sapiens	42-50
2483538-2	1989	3H-FN binds to Dowex beads coated with chondroitin sulfate GAG chains (CS) but not to beads coated with hyaluronic acid (HA).	Chondroitin Sulfates	39-58	fibronectin 1	Homo sapiens	3-5
3196705-1	1988	Fibronectin domain structure, as influenced by interaction with heparin, calcium, or chondroitin sulfate C, was analyzed by differential scanning calorimetry.	Chondroitin Sulfates	85-106	fibronectin 1	Homo sapiens	0-11
3144000-3	1988	One such molecule is a cell surface proteoglycan, named syndecan, that contains both heparan sulfate and chondroitin sulfate chains.	Chondroitin Sulfates	105-124	syndecan 1	Homo sapiens	56-64
3145477-6	1988	beta-N-Acetyl-glucosaminidase, a major catabolic enzyme of the cornea, was inhibited by the chondroitin sulfate in K-Sol by over 90% (P less than 0.01).	Chondroitin Sulfates	92-111	O-GlcNAcase	Homo sapiens	0-29
2458354-7	1988	Thus, IL 3, IL 5, and GM-CSF induce human eosinophils to augment proteoglycan biosynthesis by increasing the size of the newly synthesized proteoglycans and their individual chondroitin sulfate chains.	Chondroitin Sulfates	174-193	interleukin 3	Homo sapiens	6-10
2458354-7	1988	Thus, IL 3, IL 5, and GM-CSF induce human eosinophils to augment proteoglycan biosynthesis by increasing the size of the newly synthesized proteoglycans and their individual chondroitin sulfate chains.	Chondroitin Sulfates	174-193	interleukin 5	Homo sapiens	12-16
2458354-7	1988	Thus, IL 3, IL 5, and GM-CSF induce human eosinophils to augment proteoglycan biosynthesis by increasing the size of the newly synthesized proteoglycans and their individual chondroitin sulfate chains.	Chondroitin Sulfates	174-193	colony stimulating factor 2	Homo sapiens	22-28
2897367-2	1988	Here we report that the 250-kDa receptor subunit that binds the multifunctional protein, transforming growth factor-beta 1 (TGF-beta 1), contains chains of heparan sulfate and chondroitin sulfate and thus is a proteoglycan.	Chondroitin Sulfates	176-195	transforming growth factor beta 1	Homo sapiens	89-122
2897367-2	1988	Here we report that the 250-kDa receptor subunit that binds the multifunctional protein, transforming growth factor-beta 1 (TGF-beta 1), contains chains of heparan sulfate and chondroitin sulfate and thus is a proteoglycan.	Chondroitin Sulfates	176-195	transforming growth factor beta 1	Homo sapiens	124-134
3420027-4	1988	The positivity of S-100 immunoreaction was found to be related to the presence of stromal glycosaminoglycans of the chondroitine sulfate A and C type.	Chondroitin Sulfates	116-136	S100 calcium binding protein A1	Homo sapiens	18-23
3131116-0	1988	Metabolic labeling of human thyroglobulin with [35S]sulfate: incorporation into chondroitin 6-sulfate and endoglycosidase-F-susceptible carbohydrate units.	Chondroitin Sulfates	80-101	thyroglobulin	Homo sapiens	28-41
3131116-8	1988	Thus, human thyroglobulin contains sulfate in at least three types of carbohydrate units, 1) chondroitin 6-sulfate units, 2) complex units with no affinity for Concanavalin-A (tri- or tetraantennary forms), and 3) complex units with weak affinity for Concanavalin-A (biantennary forms).	Chondroitin Sulfates	93-114	thyroglobulin	Homo sapiens	12-25
2967302-17	1988	Heparan sulfate and chondroitin sulfate showed concentration-dependent potentiation of NGF; maximally active concentrations of heparan sulfate (100 micrograms/ml) and chondroitin sulfate (1 mg/ml) increased the potency of NGF 3-fold, whereas heparin, dermatan sulfate and hyaluronic acid had no effect.	Chondroitin Sulfates	167-186	nerve growth factor	Rattus norvegicus	222-225
2834182-1	1988	Treatment of rabbit chondrocyte cultures with PTH or (Bu)2cAMP for 30 h increased by 2- to 3-fold the incorporation of [35S]sulfate and 3H radioactivity with glucosamine as the precursor into large chondroitin sulfate proteoglycans characteristically found in cartilage matrix.	Chondroitin Sulfates	198-217	parathyroid hormone	Oryctolagus cuniculus	46-49
2967302-8	1988	Increasing concentrations of heparan sulfate, dermatan sulfate, and chondroitin sulfate correlated with increasing aFGF potentiation.	Chondroitin Sulfates	68-87	fibroblast growth factor 1	Rattus norvegicus	115-119
2448317-7	1988	In addition, a novel Mr 250,000 form of cytotactin was detected that contained chondroitin sulfate.	Chondroitin Sulfates	79-98	tenascin C	Gallus gallus	40-50
2967302-9	1988	The maximally active concentrations of heparan sulfate (100 micrograms/ml), dermatan sulfate (10 mg/ml), and chondroitin sulfate (1 mg/ml) increased the activity of aFGF 11-, 110-, and 11-fold, respectively.	Chondroitin Sulfates	109-128	fibroblast growth factor 1	Rattus norvegicus	165-169
2967302-14	1988	Maximally active concentrations of heparin (1 microgram/ml) and chondroitin sulfate (1 mg/ml) increased the potency of bFGF 5-fold.	Chondroitin Sulfates	64-83	fibroblast growth factor 2	Rattus norvegicus	119-123
2967302-17	1988	Heparan sulfate and chondroitin sulfate showed concentration-dependent potentiation of NGF; maximally active concentrations of heparan sulfate (100 micrograms/ml) and chondroitin sulfate (1 mg/ml) increased the potency of NGF 3-fold, whereas heparin, dermatan sulfate and hyaluronic acid had no effect.	Chondroitin Sulfates	20-39	nerve growth factor	Rattus norvegicus	87-90
2967302-17	1988	Heparan sulfate and chondroitin sulfate showed concentration-dependent potentiation of NGF; maximally active concentrations of heparan sulfate (100 micrograms/ml) and chondroitin sulfate (1 mg/ml) increased the potency of NGF 3-fold, whereas heparin, dermatan sulfate and hyaluronic acid had no effect.	Chondroitin Sulfates	20-39	nerve growth factor	Rattus norvegicus	222-225
2967302-17	1988	Heparan sulfate and chondroitin sulfate showed concentration-dependent potentiation of NGF; maximally active concentrations of heparan sulfate (100 micrograms/ml) and chondroitin sulfate (1 mg/ml) increased the potency of NGF 3-fold, whereas heparin, dermatan sulfate and hyaluronic acid had no effect.	Chondroitin Sulfates	167-186	nerve growth factor	Rattus norvegicus	87-90
2449172-12	1987	The mast cell proteoglycans heparin and chondroitin sulphate E, by virtue of containing the naturally occurring glycosaminoglycans of highest negative charge density, may play a major role in the regulation of mast cell tryptase activity in vivo.	Chondroitin Sulfates	40-60	tryptase delta 1	Homo sapiens	210-228
3401619-6	1988	Paper chromatography of the unsaturated disaccharides obtained by chondroitinase digestion showed that chondroitin sulfate chains were primarily 6-sulfated in the 2 studied extracts.	Chondroitin Sulfates	103-122	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	66-80
3693407-14	1987	Digestion of TAP-1 with other glycosaminoglycan lyases such as heparitinase indicates that only chondroitin sulfate is present.	Chondroitin Sulfates	96-115	transporter 1, ATP binding cassette subfamily B member	Homo sapiens	13-18
2446864-7	1987	Binding of MAG to collagen G is most effectively blocked by a high molecular weight dextran sulfate, heparan sulfate and heparin, with chondroitin sulfate and a low molecular weight dextran sulfate being less potent blockers.	Chondroitin Sulfates	135-154	myelin-associated glycoprotein	Mus musculus	11-14
3111454-4	1987	Apo B and apo A-I had significant positive correlations with the content of chondroitin sulphates A + C (CS A + C), which comprised 35% to 47% of the aortic GAG.	Chondroitin Sulfates	76-97	apolipoprotein B	Homo sapiens	0-5
3111454-4	1987	Apo B and apo A-I had significant positive correlations with the content of chondroitin sulphates A + C (CS A + C), which comprised 35% to 47% of the aortic GAG.	Chondroitin Sulfates	76-97	apolipoprotein A1	Homo sapiens	10-17
3111454-4	1987	Apo B and apo A-I had significant positive correlations with the content of chondroitin sulphates A + C (CS A + C), which comprised 35% to 47% of the aortic GAG.	Chondroitin Sulfates	76-97	chorionic somatomammotropin hormone 1	Homo sapiens	105-109
3103693-6	1987	It was thus suggested that the endo-types of beta-xylosidase, beta-galactosidase and beta-glucuronidase acted on the carbohydrate-peptide linkage region of proteo-chondroitin sulfate in the tissues and produced various types of urinary chondroitin sulfate with heterogeneity at reducing terminals.	Chondroitin Sulfates	163-182	galactosidase beta 1	Homo sapiens	62-80
3103693-6	1987	It was thus suggested that the endo-types of beta-xylosidase, beta-galactosidase and beta-glucuronidase acted on the carbohydrate-peptide linkage region of proteo-chondroitin sulfate in the tissues and produced various types of urinary chondroitin sulfate with heterogeneity at reducing terminals.	Chondroitin Sulfates	163-182	glucuronidase beta	Homo sapiens	85-103
3103693-6	1987	It was thus suggested that the endo-types of beta-xylosidase, beta-galactosidase and beta-glucuronidase acted on the carbohydrate-peptide linkage region of proteo-chondroitin sulfate in the tissues and produced various types of urinary chondroitin sulfate with heterogeneity at reducing terminals.	Chondroitin Sulfates	236-255	galactosidase beta 1	Homo sapiens	62-80
3103693-6	1987	It was thus suggested that the endo-types of beta-xylosidase, beta-galactosidase and beta-glucuronidase acted on the carbohydrate-peptide linkage region of proteo-chondroitin sulfate in the tissues and produced various types of urinary chondroitin sulfate with heterogeneity at reducing terminals.	Chondroitin Sulfates	236-255	glucuronidase beta	Homo sapiens	85-103
3680389-5	1987	The first, a high molecular weight proteoglycan, eluted from Sepharose CL-2B with a Kav of 0.07 and contained exclusively chondroitin sulfate chains with an average molecular weight greater than 50,000.	Chondroitin Sulfates	122-141	versican	Gallus gallus	35-47
3680389-8	1987	A high molecular weight proteoglycan was found with virtually identical properties to that of the high molecular weight chondroitin sulfate proteoglycan of the cell layer.	Chondroitin Sulfates	120-139	versican	Gallus gallus	24-36
3680389-8	1987	A high molecular weight proteoglycan was found with virtually identical properties to that of the high molecular weight chondroitin sulfate proteoglycan of the cell layer.	Chondroitin Sulfates	120-139	versican	Gallus gallus	140-152
3680389-9	1987	A second, smaller proteoglycan had a similar monomer size (Kav of 0.63) to the cell layer heparan sulfate proteoglycan, but differed from it in that this molecule contained primarily chondroitin sulfate chains with an average molecular weight of 32,000.	Chondroitin Sulfates	183-202	versican	Gallus gallus	18-30
3474655-2	1987	Human platelet-derived transforming growth factor type beta (TGF-beta) specifically stimulated synthesis of at least two types of chondroitin sulfate proteoglycans in nonproliferating human adult arterial smooth muscle cells in culture.	Chondroitin Sulfates	130-149	transforming growth factor beta 1	Homo sapiens	61-69
2435733-1	1987	Monoclonal antibodies produced against chick embryo limb bud proteoglycan (PG-M) were selected for their ability to recognize determinants on intact chondroitin sulfate chains.	Chondroitin Sulfates	149-168	versican	Gallus gallus	75-79
3818795-3	1987	When HBGF-2 is adsorbed to artificial extracellular matrices consisting of heparin or chondroitin sulfate, it causes the formation of cellular aggregates or circles of cells, respectively.	Chondroitin Sulfates	86-105	fibroblast growth factor 2	Gallus gallus	5-11
3104383-7	1987	It allows the simultaneous separation and analysis of HA and chondroitin sulfate isomers (after digestion of the latter with chondroitinase) at a higher speed, and with more sensitivity and efficiency.	Chondroitin Sulfates	61-80	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	125-139
3098423-0	1986	Release of inorganic sulfate ion under mild alkaline conditions from sulfated, unsaturated disaccharides obtained from chondroitin sulfates by chondroitinase digestion.	Chondroitin Sulfates	119-139	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	143-157
2442111-8	1987	All polysulfated compounds, apart from chondroitin sulfate, induced a dose-dependent release of E-CR1 bound IC in the absence of NHS.	Chondroitin Sulfates	39-58	complement C3b/C4b receptor 1 (Knops blood group)	Homo sapiens	98-101
3759976-0	1986	Chondroitin sulfate proteoglycan (PG-M-like proteoglycan) is involved in the binding of hyaluronic acid to cellular fibronectin.	Chondroitin Sulfates	0-19	versican	Gallus gallus	20-32
3759976-0	1986	Chondroitin sulfate proteoglycan (PG-M-like proteoglycan) is involved in the binding of hyaluronic acid to cellular fibronectin.	Chondroitin Sulfates	0-19	versican	Gallus gallus	34-38
3759976-0	1986	Chondroitin sulfate proteoglycan (PG-M-like proteoglycan) is involved in the binding of hyaluronic acid to cellular fibronectin.	Chondroitin Sulfates	0-19	versican	Gallus gallus	44-56
3759976-0	1986	Chondroitin sulfate proteoglycan (PG-M-like proteoglycan) is involved in the binding of hyaluronic acid to cellular fibronectin.	Chondroitin Sulfates	0-19	fibronectin 1	Gallus gallus	116-127
3094551-6	1986	Although total GAG concentrations did not differ between a normolipemic control and the two diet groups, apoB showed a significantly positive correlation with the percent of total GAG that was chondroitin sulfate and a significantly negative correlation with the percent of total GAG that was dermatan sulfate.	Chondroitin Sulfates	193-212	apolipoprotein B	Sus scrofa	105-109
3745204-7	1986	Chondroitin sulfate and polygalacturonic acid competed only weakly for bound 125I-fibrinogen.	Chondroitin Sulfates	0-19	fibrinogen beta chain	Homo sapiens	82-92
3768894-5	1986	The silkworm lectin had the highest affinity for dermatan sulfate and hyaluronic acid, followed by protuberic acid, heparin, and chondroitin sulfate A.	Chondroitin Sulfates	129-150	hemocytin	Bombyx mori	13-19
3011858-6	1986	The M-protein appeared to bind to chondroitin sulfate containing proteoglycans in peripheral nerve.	Chondroitin Sulfates	34-53	myomesin 2	Homo sapiens	4-13
2425853-2	1986	Affinity chromatography of the fraction with antithrombin III-agarose yielded two chondroitin sulfate proteoglycans of a non-binding (proteoglycan IA) and binding (proteoglycan IB) nature.	Chondroitin Sulfates	82-101	serpin family C member 1	Homo sapiens	45-61
3089205-5	1986	All glycosaminoglycans were identified as chondroitin sulfate sulfated at the C-6 position.	Chondroitin Sulfates	42-61	complement C6	Homo sapiens	78-81
2418787-2	1986	Chondroitin sulfate proteoglycan, when added exogenously, promotes the binding of chondronectin, the chondrocyte attachment factor, to type II collagen substrates and thereby stimulates chondrocyte adhesion.	Chondroitin Sulfates	0-19	collagen type II alpha 1 chain	Gallus gallus	135-151
3086452-11	1986	They are homologous to the chondroitin sulfate-rich proteoglycans of the transformed rat basophilic leukemia-1 cell and the cultured interleukin 3-dependent mouse bone marrow-derived mast cell, in that these chondroitin sulfate proteoglycans as well as rat serosal mast cell heparin proteoglycans are all highly sulfated, protease-resistant proteoglycans.	Chondroitin Sulfates	27-46	interleukin 3	Rattus norvegicus	133-146
3086452-11	1986	They are homologous to the chondroitin sulfate-rich proteoglycans of the transformed rat basophilic leukemia-1 cell and the cultured interleukin 3-dependent mouse bone marrow-derived mast cell, in that these chondroitin sulfate proteoglycans as well as rat serosal mast cell heparin proteoglycans are all highly sulfated, protease-resistant proteoglycans.	Chondroitin Sulfates	208-227	interleukin 3	Rattus norvegicus	133-146
3084487-8	1986	Analysis by high-performance liquid chromatography of the disaccharides generated by chondroitinase ABC digestion revealed that chondroitin 6-sulfate was the predominant isomer.	Chondroitin Sulfates	128-149	galactosamine (N-acetyl)-6-sulfatase	Rattus norvegicus	85-99
3088212-3	1986	In vitro studies showed that the antiserum binds to the unsaturated disaccharide that remains attached to the core protein after digestion of the CS chains with chondroitinase ABC (Ch ABC).	Chondroitin Sulfates	146-148	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	176-179
3088212-4	1986	As the disaccharide is created specifically by Ch ABC digestion of the CS chains, the antiserum allows the immunolocalization of CS on tissue sections digested with Ch ABC.	Chondroitin Sulfates	71-73	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	50-53
3088212-4	1986	As the disaccharide is created specifically by Ch ABC digestion of the CS chains, the antiserum allows the immunolocalization of CS on tissue sections digested with Ch ABC.	Chondroitin Sulfates	129-131	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	50-53
3088212-4	1986	As the disaccharide is created specifically by Ch ABC digestion of the CS chains, the antiserum allows the immunolocalization of CS on tissue sections digested with Ch ABC.	Chondroitin Sulfates	129-131	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	168-171
3741402-9	1986	Affinity chromatography of these proteoglycans on columns of either immobilized platelet factor 4 or immobilized plasma fibronectin revealed that most of the chondroitin sulphate proteoglycan and the heparan sulphate proteoglycan bound to platelet factor 4 but that only the heparan sulphate proteoglycan bound to fibronectin, providing a ready means of separating the two proteoglycan classes.	Chondroitin Sulfates	158-178	fibronectin 1	Mus musculus	120-131
4022379-2	1985	In one patient with axonal neuropathy studied, the IgM M-protein bound to chondroitin sulfate, and there were deposits of IgM in the endoneurium of the patient"s nerve.	Chondroitin Sulfates	74-93	myomesin 2	Homo sapiens	55-64
3718422-4	1986	On the contrary, the presence of chondroitinsulfate in the growth medium completely inhibited UDPGDH activity.	Chondroitin Sulfates	33-51	UDP-glucose 6-dehydrogenase	Homo sapiens	94-100
3492025-2	1986	Several lines of evidence suggest that this factor is distinct from the documented C1q inhibitor which is a chondroitin sulphate.	Chondroitin Sulfates	108-128	complement C1q A chain	Homo sapiens	83-86
4069203-2	1985	In recent studies, human NK cell clones have been shown to contain a 200,000-Mr (relative molecular mass) protease-resistant chondroitin sulphate A proteoglycan, which has been localized to the secretory granule by X-ray dispersive analysis and by its resistance to cleavage by extracellular addition of chondroitinase AC or ABC (ref.	Chondroitin Sulfates	125-145	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	325-328
3932350-1	1985	Chondroitin sulfate E proteoglycan was extracted in the presence of protease inhibitors from 6 X 10(9) mouse bone marrow-derived, interleukin 3-dependent mast cells, of which 3 X 10(7) had been biosynthetically labeled with [35S]sulfate or [3H]glycine.	Chondroitin Sulfates	0-19	interleukin 3	Mus musculus	130-143
4084217-4	1985	The purified enzyme catalyzed the hydrolysis of p-nitrocatechol sulfate (pNCS), 4-methylumbelliferyl sulfate (4MUS), and chondroitin-4-sulfate (C4S) heptasaccharide.	Chondroitin Sulfates	144-147	carbohydrate sulfotransferase 11	Mus musculus	121-134
3925958-3	1985	These peptides appeared to be derived primarily from the chondroitin sulfate-rich region of the proteoglycan core protein.	Chondroitin Sulfates	57-76	decorin	Homo sapiens	96-121
3931626-9	1985	We propose that some, if not all, of the sulphated N-acetylhexosamine present in human urine is derived from the action of beta-N-acetylhexosaminidase on sulphated GlcNAc or GalNAc residues at the non-reducing end of keratan sulphate, dermatan sulphate or chondroitin sulphate.	Chondroitin Sulfates	256-276	O-GlcNAcase	Homo sapiens	123-150
2985627-6	1985	This large chondroitin sulfate proteoglycan is the only type found in muscle cultures as determined both biochemically in the past and now by electron microscopy and is referred to as muscle proteoglycan.	Chondroitin Sulfates	11-30	versican	Gallus gallus	31-43
3934789-1	1985	Human urinary chondroitin sulfate isolated from the cetylpyridinium chloride-complex of the non-dialyzable fraction of the pooled urine was subjected to ethanol fractionation, successive enzymic digestion with neuraminidase and mucopolysaccharidases, and anion exchange chromatography.	Chondroitin Sulfates	14-33	neuraminidase 1	Homo sapiens	210-223
3923482-7	1985	The transformed RBL-1 tumor cells, whose growth is independent of factors other than those present in standard tissue culture medium, has previously been shown to contain predominantly chondroitin sulfate di-B proteoglycans and low amounts of histamine.	Chondroitin Sulfates	185-204	RB transcriptional corepressor like 1	Rattus norvegicus	16-21
2985627-6	1985	This large chondroitin sulfate proteoglycan is the only type found in muscle cultures as determined both biochemically in the past and now by electron microscopy and is referred to as muscle proteoglycan.	Chondroitin Sulfates	11-30	versican	Gallus gallus	191-203
3158311-1	1985	A method was developed for the analysis of non-reducing terminal structure of radiolabelled chondroitin sulphate chains with the aid of N-acetylgalactosamine 4-sulphatase ("terminal 4-sulphatase"), N-acetylgalactosamine 6-sulphatase ("terminal 6-sulphatase"), beta-glucuronidase and beta-N-acetylhexosaminidase.	Chondroitin Sulfates	92-112	glucuronidase, beta	Rattus norvegicus	260-278
3158311-1	1985	A method was developed for the analysis of non-reducing terminal structure of radiolabelled chondroitin sulphate chains with the aid of N-acetylgalactosamine 4-sulphatase ("terminal 4-sulphatase"), N-acetylgalactosamine 6-sulphatase ("terminal 6-sulphatase"), beta-glucuronidase and beta-N-acetylhexosaminidase.	Chondroitin Sulfates	92-112	O-GlcNAcase	Rattus norvegicus	283-310
3917943-8	1985	The subcellular distribution pattern of the chondroitin sulfate-synthesizing enzymes corroborated the proposed topological modifications of the proteoglycan core protein precursor.	Chondroitin Sulfates	44-63	decorin	Homo sapiens	144-169
2578417-2	1985	Characterization of the specificity of these antibodies indicated that they recognize determinants present in the keratan sulfate glycosaminoglycan chain and on chondroitin sulfate oligosaccharide stubs attached to the proteoglycan core protein after chondroitinase digestion of the proteoglycan (i.e., delta-unsaturated 4- and 6-sulfated and unsulfated chondroitin sulfate on the proteoglycan core).	Chondroitin Sulfates	161-180	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	251-265
6084876-6	1984	Heparin, dextran sulfate and chondroitin polysulfates 1 and 5 activated both HC II and AT III, while dermatan sulfate activated only HC II.	Chondroitin Sulfates	29-53	serpin family D member 1	Homo sapiens	77-82
3989479-4	1985	The sequential application of chondroitinase AC and ABC permits the determination of hyaluronate, the chondroitin sulphate isomers and the dermatan sulphate isomers by high performance liquid chromatographic separation of the products of enzymatic hydrolysis.	Chondroitin Sulfates	102-122	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	52-55
3917684-10	1985	The presence of chondroitin sulfate or hyaluronic acid slightly increases the binding of native acetylcholinesterase to sphingomyelin vesicles, while the presence of 1 M NaCl, bovine serum albumin, or tissue fractions enriched in basement membrane diminish binding.	Chondroitin Sulfates	16-35	acetylcholinesterase (Cartwright blood group)	Homo sapiens	96-116
6430574-0	1984	Interaction between human leukocyte elastase and chondroitin sulfate.	Chondroitin Sulfates	49-68	elastase, neutrophil expressed	Homo sapiens	26-44
6332858-1	1984	Both mouse and rat sera have been found to inhibit proliferation in vitro of interleukin 3-dependent chondroitin sulfate E proteoglycan-containing mouse bone marrow-derived mast cells (BMMC), as assessed by quantitation of 3H-labeled thymidine incorporation into DNA, cell cycle analysis, and cell number.	Chondroitin Sulfates	101-120	interleukin 3	Rattus norvegicus	77-90
6430574-1	1984	Chondroitin sulfate (Structum) interacts with human leukocyte elastase, a potent mediator of articular cartilage degradation, producing a partial inhibition of the enzyme activity (60% at saturation).	Chondroitin Sulfates	0-19	elastase, neutrophil expressed	Homo sapiens	52-70
6430574-1	1984	Chondroitin sulfate (Structum) interacts with human leukocyte elastase, a potent mediator of articular cartilage degradation, producing a partial inhibition of the enzyme activity (60% at saturation).	Chondroitin Sulfates	21-29	elastase, neutrophil expressed	Homo sapiens	52-70
6384678-8	1984	These findings suggest that the synthesis and/or degradation of the various types of glycosaminoglycan chains (chondroitin sulfate and keratan sulfate) of cartilage proteoglycan can be regulated differentially by serum growth factors.	Chondroitin Sulfates	111-130	versican	Gallus gallus	165-177
6235872-3	1984	These observations prompted the investigation of the effects of four normal vessel wall glycosaminoglycans (heparan sulfate, dermatan sulfate, chondroitin-4-sulfate, and chondroitin-6-sulfate) on the intrinsic pathway generation of thrombin and factor Xa and on the inactivation of thrombin and factor Xa in plasma.	Chondroitin Sulfates	143-164	coagulation factor II, thrombin	Homo sapiens	232-240
6235872-3	1984	These observations prompted the investigation of the effects of four normal vessel wall glycosaminoglycans (heparan sulfate, dermatan sulfate, chondroitin-4-sulfate, and chondroitin-6-sulfate) on the intrinsic pathway generation of thrombin and factor Xa and on the inactivation of thrombin and factor Xa in plasma.	Chondroitin Sulfates	170-191	coagulation factor II, thrombin	Homo sapiens	232-240
6586291-3	1984	The major GAG component of HL60/HGPRT- was chondroitin 4-sulfate.	Chondroitin Sulfates	43-64	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	32-37
6202346-0	1984	In vitro activation of the contact (Hageman factor) system of plasma by heparin and chondroitin sulfate E. A large number of negatively charged macromolecules, including DNA, glycosaminoglycans, and proteoglycans, were tested as possible activators of the contact (Hageman factor) system in vitro.	Chondroitin Sulfates	84-103	coagulation factor XII	Rattus norvegicus	36-50
6198393-0	1984	Interleukin 3: A differentiation and growth factor for the mouse mast cell that contains chondroitin sulfate E proteoglycan.	Chondroitin Sulfates	89-108	interleukin 3	Mus musculus	0-13
6198393-10	1984	Thus, T cell-derived IL 3 is the component present in the conditioned media that is required for differentiation and growth of the subclass of mast cells containing chondroitin sulfate E proteoglycan, designated E-MC.	Chondroitin Sulfates	165-184	interleukin 3	Mus musculus	21-25
6363164-8	1984	These regional patterns are probably due to differences in the composition of fibronectin-associated material such as chondroitin sulfate A and/or C proteoglycans, and/or hyaluronate, before and after mesoblast expansion, rather than to differences in the distribution of fibronectin itself.	Chondroitin Sulfates	118-139	fibronectin 1	Gallus gallus	78-89
6195665-3	1983	Separation of the various labeled glycosaminoglycans by chondroitinase digestion and chromatography revealed a transient rise from controls (P less than or equal to 0.05) in the proportion of labeled chondroitin 4-sulfate at 5 days, followed by an increase from controls (P less than or equal to 0.05) in proportionate labeling of dermatan sulfate at 15 and 45 days postbleomycin.	Chondroitin Sulfates	200-221	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	56-70
6885814-3	1983	PG I, eluting at the column void volume, contained predominantly (83.2%) chondroitin sulfate whereas PG II, eluting at a Kav of 0.40, contained predominantly dermatan sulfate (54.7%).	Chondroitin Sulfates	73-92	biglycan	Homo sapiens	0-4
6885814-5	1983	Only PG I, predominantly chondroitin sulfate, was effective in associating with hyaluronic acid to form high molecular weight aggregates.	Chondroitin Sulfates	25-44	biglycan	Homo sapiens	5-9
2581830-14	1985	(b) FN promotes the increased retention of HA, CSPG, and to a very small degrees, CS, in collagen gels.	Chondroitin Sulfates	47-49	fibronectin 1	Homo sapiens	4-6
2581830-16	1985	Furthermore, FN binds to HA, CS, and CSPG as demonstrated by solid surface binding assays and morphological criteria.	Chondroitin Sulfates	29-31	fibronectin 1	Homo sapiens	13-15
6418214-5	1983	Experiments in vitro revealed the sulfated glycosaminoglycans chondroitin 4-sulfate and heparin, the polysaccharide dextran sulfate, and the trypanocidal drug suramin to be strongly inhibitory on the ganglioside GD1a neuraminidase activity of normal fibroblast homogenates.	Chondroitin Sulfates	62-83	neuraminidase 1	Homo sapiens	217-230
6184439-8	1983	Linear regression analyses of the net percent release of beta-hexosaminidase to histamine and of 35S-chondroitin sulfate E to beta-hexosaminidase yielded straight lines that intersected at the origin, which indicates that the three preformed mediators are localized in the secretory granules of the bone marrow-derived mast cells.	Chondroitin Sulfates	101-120	O-GlcNAcase	Mus musculus	126-145
6833245-10	1983	Cellular heparan sulfate decreased by 70% in response to NGF and increased by an equivalent amount in the culture medium, whereas an NGF-induced increase in chondroitin sulfate labeling occurred specifically in the cell membranes.	Chondroitin Sulfates	157-176	nerve growth factor	Rattus norvegicus	133-136
6219115-5	1983	PF4-mediated responses were blocked by treating the PF4-adsorbed substratum with heparin (but not chondroitin sulfate), or alternatively the cells with Flavobacter heparinum heparinase (but not chondroitinase ABC).	Chondroitin Sulfates	98-117	platelet factor 4	Mus musculus	0-3
6411747-6	1983	When added to fibronectin, chondroitin sulphate appears to reduce adhesions slightly, since the cells are more rounded.	Chondroitin Sulfates	27-47	fibronectin 1	Homo sapiens	14-25
7118896-9	1982	The chondroitinase AC digest of the proteoglycan is sensitive to hydrolysis by chondro-4-sulfatase but not by chondro-6-sulfatase, indicating the presence of chondroitin 4-sulfate but not chondroitin 6-sulfate in the proteoglycan molecule.	Chondroitin Sulfates	158-179	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	4-18
7118896-9	1982	The chondroitinase AC digest of the proteoglycan is sensitive to hydrolysis by chondro-4-sulfatase but not by chondro-6-sulfatase, indicating the presence of chondroitin 4-sulfate but not chondroitin 6-sulfate in the proteoglycan molecule.	Chondroitin Sulfates	188-209	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	4-18
6210440-0	1982	Structure of the pericellular matrix: association of heparan and chondroitin sulfates with fibronectin-procollagen fibers.	Chondroitin Sulfates	65-85	fibronectin 1	Homo sapiens	91-102
6809361-3	1982	Our results could be explained by the hypothesis that accumulation of keratan sulfate and chondroitin 6-sulfate in Morquio syndrome is due to a deficiency of galactose 6-sulfate sulfatase and N-acetylgalactosamine 6-sulfate sulfatase activity, which are necessary for the degradation of these two mucopolysaccharides.	Chondroitin Sulfates	90-111	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	158-187
6809361-3	1982	Our results could be explained by the hypothesis that accumulation of keratan sulfate and chondroitin 6-sulfate in Morquio syndrome is due to a deficiency of galactose 6-sulfate sulfatase and N-acetylgalactosamine 6-sulfate sulfatase activity, which are necessary for the degradation of these two mucopolysaccharides.	Chondroitin Sulfates	90-111	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	192-233
6802163-2	1982	Normal and sclerotic CSs accelerated the inactivation of thrombin by antithrombin III to an equal extent.	Chondroitin Sulfates	21-24	coagulation factor II, thrombin	Homo sapiens	57-65
6802163-2	1982	Normal and sclerotic CSs accelerated the inactivation of thrombin by antithrombin III to an equal extent.	Chondroitin Sulfates	21-24	serpin family C member 1	Homo sapiens	69-85
6802163-4	1982	However, anticoagulant activity of sclerotic CSs in thrombin-catalysed fibrin clot formation in platelet-poor plasma was lower than that of normal CSs.	Chondroitin Sulfates	45-48	coagulation factor II, thrombin	Homo sapiens	52-60
7054188-4	1982	This change of buoyant density was directly related to a decrease in average sulfation degree of the chondroitin sulfate moiety, which in turn reflected an increase in the ratio of low sulfated chondroitin chains (Chn) to high sulfated chondroitin sulfate chains (CS) per proteoglycan molecule.	Chondroitin Sulfates	101-120	versican	Gallus gallus	272-284
6788768-0	1981	The C1q inhibitor in serum is a chondroitin 4-sulfate proteoglycan.	Chondroitin Sulfates	32-53	complement C1q A chain	Homo sapiens	4-7
6791428-6	1981	It was postulated that IGF could stimulate proteoglycan synthesis not only by elongating existing chondroitin sulphate chains but also by increased synthesis of other sugar chains e.g. keratan sulphate and oligosaccharides.	Chondroitin Sulfates	98-118	versican	Gallus gallus	43-55
6788768-5	1981	Additional evidence for the noncartilaginous origin of C1q inhibitor is that its glycosaminoglycan chains totally lack chondroitin 6-sulfate isomers.	Chondroitin Sulfates	119-140	complement C1q A chain	Homo sapiens	55-58
102653-2	1978	The substituted unsaturated disaccharides which result from digestion of chondroitin sulfates with chondroitinase are quickly separated on polar absorbents such as silica gel.	Chondroitin Sulfates	73-93	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	99-113
6456128-5	1981	It was also found that alpha-elastin methyl ester formed aggregates with hyaluronic acid, chondroitin sulfate, proteoglycan subunits and solubilized structural glycoproteins at room temperature and under conditions close to physiological ones.	Chondroitin Sulfates	90-109	elastin	Homo sapiens	29-36
6800936-2	1981	The binding of the alkaline phosphatase conjugated fibronectin to C1q was dose dependent and inhibited by fibronectin and by the sulfated polymers heparin and chondroitin sulfate.	Chondroitin Sulfates	159-178	fibronectin 1	Homo sapiens	51-62
6800936-2	1981	The binding of the alkaline phosphatase conjugated fibronectin to C1q was dose dependent and inhibited by fibronectin and by the sulfated polymers heparin and chondroitin sulfate.	Chondroitin Sulfates	159-178	complement C1q A chain	Homo sapiens	66-69
6156167-5	1980	However, the disaccharide obtained from chondroitin 4-sulfate by the action of chondroitinase ABC, 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-4-O-sulfo-D-galactose, inhibited the interaction 50% at a concentration of 500 microM.	Chondroitin Sulfates	40-61	galactosamine (N-acetyl)-6-sulfatase	Rattus norvegicus	79-93
447623-0	1979	High performance liquid chromatography of unsaturated disaccharides produced from chondroitin sulfates by chondroitinase.	Chondroitin Sulfates	82-102	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	106-120
447623-1	1979	High performance liquid chromatography was performed by the ion pair method on unsaturated disaccharides produced from chondroitin sulfates by the action of chondroitinase.	Chondroitin Sulfates	119-139	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	157-171
442079-0	1979	Contribution of beta-glucuronidase to the degradation of chondroitin 4-sulfate by canine liver lysosomal enzymes.	Chondroitin Sulfates	57-78	glucuronidase beta	Canis lupus familiaris	16-34
442079-2	1979	The degree of digestion of Ch4-S by hyaluronidase and beta-glucuronidase was examined on the basis of types of the digestion products.	Chondroitin Sulfates	27-32	glucuronidase beta	Canis lupus familiaris	54-72
442079-5	1979	The results showed that decasaccharide from Ch4-S served as the largest-molecular-weight substrate for beta-glucuronidase in the degradation of Ch4-S by the enzymes of lysosomes in contrast to the results of the digestion studies of hyaluronic acid (HA).	Chondroitin Sulfates	44-49	glucuronidase beta	Canis lupus familiaris	103-121
442079-5	1979	The results showed that decasaccharide from Ch4-S served as the largest-molecular-weight substrate for beta-glucuronidase in the degradation of Ch4-S by the enzymes of lysosomes in contrast to the results of the digestion studies of hyaluronic acid (HA).	Chondroitin Sulfates	144-149	glucuronidase beta	Canis lupus familiaris	103-121
442079-8	1979	From the results, it is suggested that beta-glucuronidase contributes to the degradation of the even-numbered oligosaccharides which inhibit the action of hyaluronidase in the depolymerization of Ch4-S.	Chondroitin Sulfates	196-201	glucuronidase beta	Canis lupus familiaris	39-57
762100-15	1979	Digestion with trypsin, chymotrypsin, or plasmin released dermatan sulfate-peptides nearly as small as those released by papain or alkali; in contrast, cartilage proteoglycans were resistant to plasmin and released peptides containing an average of more than four chondroitin sulfate chains after trypsin or chymotrypsin digestion.	Chondroitin Sulfates	264-283	plasminogen	Bos taurus	41-48
218319-4	1978	These bodies were 15--25 micrometer in diameter with an iron rich outer rim and core of connective tissue mucin--possibly chondroitin sulphate or dermatan sulphate.	Chondroitin Sulfates	122-142	LOC100508689	Homo sapiens	106-111
6812235-1	1982	Chondroitin-4-sulfate (chondroitin sulfate A, CSA) is a natural glycosaminoglycan which has been shown to have antithrombotic effects in vivo.	Chondroitin Sulfates	0-21	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	46-49
6452123-2	1980	Lipoprotein lipase (EC 3.1.1.34), which was previously shown to bind to immobilized heparin, was now found to bind also to heparan sulphate and dermatan sulphate and to some extent to chondroitin sulphate.	Chondroitin Sulfates	184-204	lipoprotein lipase	Rattus norvegicus	0-18
7209966-7	1980	The present observations provided with evidence for the action of endo-beta-glucuronidase and endo-beta-N-acetylhexosaminidase on the tissue GAG, specifically on chondroitin sulfates.	Chondroitin Sulfates	162-182	glucuronidase beta	Homo sapiens	71-89
7209966-7	1980	The present observations provided with evidence for the action of endo-beta-glucuronidase and endo-beta-N-acetylhexosaminidase on the tissue GAG, specifically on chondroitin sulfates.	Chondroitin Sulfates	162-182	O-GlcNAcase	Homo sapiens	99-126
6771264-3	1980	Fibronectin isolated from chick embryo fibroblasts binds both hyaluronic acid and heparin; heparan sulfate is bound less efficiently, and chondroitin sulfate and glycopeptides are bound minimally.	Chondroitin Sulfates	138-157	fibronectin 1	Gallus gallus	0-11
6773185-1	1980	A 6-sulfated tetrasaccharide obtained by digesting chondroitin-6-sulfate with testicular hyaluronidase was used as a substrate for the determination of N-acetylgalactosamine-6-sulfate sulfatase activity.	Chondroitin Sulfates	51-72	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	152-193
7378054-4	1980	The two proteoglycan populations were of similar average chemical composition and similar in the size of their chondroitin sulphate chains.	Chondroitin Sulfates	111-131	versican	Gallus gallus	8-20
536687-9	1979	The degree of sulfation of chondroitin sulfate was reduced from 80% in control sterna to 40% in treated sterna; almost all of this chondroitin sulfate was attached to peptide and the sedimentation pattern of the proteoglycan resembled that of normal cartilage proteoglycan.	Chondroitin Sulfates	27-46	versican	Gallus gallus	212-224
536687-9	1979	The degree of sulfation of chondroitin sulfate was reduced from 80% in control sterna to 40% in treated sterna; almost all of this chondroitin sulfate was attached to peptide and the sedimentation pattern of the proteoglycan resembled that of normal cartilage proteoglycan.	Chondroitin Sulfates	27-46	versican	Gallus gallus	260-272
444561-6	1979	Chondroitin 4-sulfate was the only sulfated glycosaminoglycan identified in the proteoglycan lost from the platelet surface during ADP-induced aggregation and in the proteoglycan released from the granules when the platelets were exposed to thrombin.	Chondroitin Sulfates	0-21	prothrombin	Oryctolagus cuniculus	241-249
148364-2	1978	High concentrations of chondroitin sulphate A, B and C and heparitin sulphate partly or completely inhibited the response of CFU-E to erythropoietin stimulation whereas addition of heparin, hyalyronic acid and keratan sulphate II in concentrations up to 100 microgram/ml did not elicit an inhibition of erythrocytic colony formation.	Chondroitin Sulfates	23-45	erythropoietin	Mus musculus	134-148
891725-2	1977	Most of it is in the elastin-rich residue not extractable by 4 M guanidinium chloride where it is associated with chondroitin sulphate in low relative concentration and of lower molecular weight than in non-elastic cartilage residue.	Chondroitin Sulfates	114-134	elastin	Bos taurus	21-28
710712-0	1978	The O-, 4- and 6-sulphated disaccharides of chondroitin sulphates: their electrophoretic separation and detection with p-anisidine [proceedings].	Chondroitin Sulfates	44-65	immunoglobulin kappa variable 1D-37 (non-functional)	Homo sapiens	4-16
74186-6	1977	Increased levels of chondroitin sulfate N-acetylgalactosamine-6-sulfate sulfatase and sulfamidase and decreased enzymic levels of arylsulfatase A and B (EC 3.1.6.1) were found in leucocytes of DMC patients.	Chondroitin Sulfates	20-39	arylsulfatase family member H	Homo sapiens	72-81
150963-3	1978	Treatment of the phosphorylated proteoglycans with chondroitinase and chondrosulfatases effectively removed the chondroitin sulfate without dephosphorylating the remaining molecule.	Chondroitin Sulfates	112-131	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	51-65
603626-10	1977	Of the four proteinases, only cathepsin B produced peptides that contained a single chondroitin sulphate chain.	Chondroitin Sulfates	84-104	cathepsin B	Bos taurus	30-41
598455-2	1977	The interaction of phosphate and citrate with chondroitin sulfate-A (CSA) in binding to collagen was investigated in different environmental conditions.	Chondroitin Sulfates	69-72	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	46-67
615734-2	1977	Paper chromatographic separation of the constitutional disaccharide units by digestion of chondroitin sulfates (CS) with chondroitinase-ABC and chondroitinase-AC was carried out after fractionation of CS by ion-exchange resin column chromatography.	Chondroitin Sulfates	90-110	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	121-135
615734-2	1977	Paper chromatographic separation of the constitutional disaccharide units by digestion of chondroitin sulfates (CS) with chondroitinase-ABC and chondroitinase-AC was carried out after fractionation of CS by ion-exchange resin column chromatography.	Chondroitin Sulfates	112-114	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	121-135
820716-2	1976	Human N-acetylgalactosamine-6-sulfate sulfatase (6-sulfatase) activity is measured by using as a substrate a sulfated tetrasaccharide obtained by digesting purified chondroitin-6-sulfate (C-6-S) with testicular hyaluronidase.	Chondroitin Sulfates	165-186	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	6-47
830761-6	1977	Similar C1 binding and C consumption in the presence of CRP were seen upon the interaction of multiple additional polyanions including DNA, ENA, hyaluronic acid, chondroitin sulfate, and dextran sulfate with the polycations protamine sulfate and poly-L-lysine.	Chondroitin Sulfates	162-181	C-reactive protein	Homo sapiens	56-59
1269836-0	1976	Undersulfated chondroitin sulfate in the cartilage matrix of brachymorphic mice.	Chondroitin Sulfates	14-33	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Mus musculus	61-74
820716-2	1976	Human N-acetylgalactosamine-6-sulfate sulfatase (6-sulfatase) activity is measured by using as a substrate a sulfated tetrasaccharide obtained by digesting purified chondroitin-6-sulfate (C-6-S) with testicular hyaluronidase.	Chondroitin Sulfates	165-186	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	49-60
820716-2	1976	Human N-acetylgalactosamine-6-sulfate sulfatase (6-sulfatase) activity is measured by using as a substrate a sulfated tetrasaccharide obtained by digesting purified chondroitin-6-sulfate (C-6-S) with testicular hyaluronidase.	Chondroitin Sulfates	188-193	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	6-47
820716-2	1976	Human N-acetylgalactosamine-6-sulfate sulfatase (6-sulfatase) activity is measured by using as a substrate a sulfated tetrasaccharide obtained by digesting purified chondroitin-6-sulfate (C-6-S) with testicular hyaluronidase.	Chondroitin Sulfates	188-193	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	49-60
128355-4	1975	Proteoglycans were then digested exhaustively with testicular hyaluronidase, which removed about 80% of the chondroitin sulphate.	Chondroitin Sulfates	108-128	hemopexin	Sus scrofa	62-75
4122-2	1976	The activity of a partially purified preparation of tyrosine hydroxylase (EC 1.14.16.2) from the bovine caudate nucleus was increased by heparin, chondroitin sulfate, phosphatidylserine, polyacrylic acid, polyvinyl sulfuric acid and both poly-D-, and poly-L-glutamic acids, all polyanions.	Chondroitin Sulfates	146-165	tyrosine hydroxylase	Bos taurus	52-72
1023336-1	1976	In the byosinthesis of glycosaminoglycans, UDP-glucose is utilized by two enzymes: UDP-glucose dehydrogenase which produces UDP-glucuronic acid (chondroitin sulphate precursor), and UDP-glucose 4"-epimerase which produces UDP-galactose (keratan sulphate precursor).	Chondroitin Sulfates	145-165	UDP-glucose 6-dehydrogenase	Homo sapiens	83-108
1023336-1	1976	In the byosinthesis of glycosaminoglycans, UDP-glucose is utilized by two enzymes: UDP-glucose dehydrogenase which produces UDP-glucuronic acid (chondroitin sulphate precursor), and UDP-glucose 4"-epimerase which produces UDP-galactose (keratan sulphate precursor).	Chondroitin Sulfates	145-165	UDP-galactose-4-epimerase	Homo sapiens	182-206
33043980-4	2021	It was shown that CS oligosaccharides could block Abeta-induced oxidative stress, mitochondrial dysfunction and activation of intrinsic apoptotic pathway for SH-SY5Y cells.	Chondroitin Sulfates	18-20	amyloid beta precursor protein	Homo sapiens	50-55
807169-0	1975	Proceedings: Alpha-L-iduronidase deficiency associated with chondroitin sulphate mucopolysaccharidosis.	Chondroitin Sulfates	60-80	alpha-L-iduronidase	Homo sapiens	13-32
1131282-3	1975	The rise in serum lysozyme paralleled the rise in serum chondroitin sulfate.	Chondroitin Sulfates	56-75	lysozyme C-like	Oryctolagus cuniculus	18-26
24194402-2	1975	aureus by human blood leukocyte lysates, by extracts of rabbit small intestines and pancreas, and by the "cocktail" of enzymes (containing trypsin, lysolecithin, and lysozyme) is strongly inhibited by anionic polyelectrolytes (e.g., heparin, chondroitin sulfate, liquoid (polyanethole sulfonic acid), and DNA).	Chondroitin Sulfates	242-261	lysozyme C-like	Oryctolagus cuniculus	166-174
4412070-0	1974	Appearance of lipoprotein lipase activity in the blood streams of humans and rats after administration of a chondroitin polysulfate.	Chondroitin Sulfates	108-131	lipoprotein lipase	Homo sapiens	14-32
4832058-0	1974	Experimental modification of patterns of cell death and chondrogenesis in insulin-induced micromelia of the developing chick limb: an autoradiographic analysis of 35SO4 uptake into chondroitin sulfate.	Chondroitin Sulfates	181-200	insulin	Gallus gallus	74-81
4747599-0	1973	Antagonistic action of chondroitin sulphate and cetylpyridinium chloride on human liver beta-galactosidase.	Chondroitin Sulfates	23-43	galactosidase beta 1	Homo sapiens	88-106
4797576-0	1973	[Viscometric studies on the interaction between sodium chondroitin sulfate and bovine serum albumin (author"s transl)].	Chondroitin Sulfates	48-74	albumin	Homo sapiens	86-99
4268963-5	1973	After the addition of chondroitin sulfate, the total activity of beta-galactosidase is inhibited, whereas other hydrolases are affected only slightly or not at all.	Chondroitin Sulfates	22-41	galactosidase beta 1	Homo sapiens	65-83
4639012-3	1972	The ability of cations to extract lysozyme from cartilage agreed with their known affinities for binding to chondroitin sulfate.	Chondroitin Sulfates	108-127	lysozyme	Homo sapiens	34-42
4639012-5	1972	Cartilage incubated in excess exogenous lysozyme could bind 0.053 equivalents of lysozyme per equivalent of chondroitin sulfate.	Chondroitin Sulfates	108-127	lysozyme	Homo sapiens	40-48
4639012-5	1972	Cartilage incubated in excess exogenous lysozyme could bind 0.053 equivalents of lysozyme per equivalent of chondroitin sulfate.	Chondroitin Sulfates	108-127	lysozyme	Homo sapiens	81-89
5038324-4	1972	The growth of tumour cells which were injected subcutaneously after in vitro incubation with chondroitinase-ABC or -AC solution was decreased when compared with that of sham-treated cells.The injection of 1 ml of chondroitin sulphate A and chondroitin sulphate C solution prior to tumour inoculation into the same site promoted the tumour growth, while growth-stimulating effect of chondroitin sulphate B was ambiguous.	Chondroitin Sulfates	213-235	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	93-107
5456794-3	1970	The components of cartilage responsible for this effect are the proteinpolysaccharides, compounds of protein and chondroitin sulfate, called PPL.	Chondroitin Sulfates	113-132	periplakin	Homo sapiens	141-144
5260274-0	1968	[Effect of lysozyme on the promotion of activity of chondroitin sulfate on the growth of solid Ehrlich ascites tumor].	Chondroitin Sulfates	52-71	lysozyme	Homo sapiens	11-19
16742485-6	1967	This fraction interacted electrostatically with chondroitin sulphate only when rendered more basic by removal of sialic acid residues with neuraminidase.	Chondroitin Sulfates	48-68	neuraminidase 1	Homo sapiens	139-152
14104083-2	1964	In hypophysectomized animals the turnover of chondroitin sulfate and hyaluronic acid is decreased; when such animals are given growth hormone the turnover of chondroitin sulfate is enhanced but that of hyaluronic acid is unaltered.	Chondroitin Sulfates	158-177	gonadotropin releasing hormone receptor	Rattus norvegicus	127-141
33781652-5	2021	In the case of monocytes, an additional dependence of CCL2-induced chemotaxis on chondroitin sulfate was observed.	Chondroitin Sulfates	81-100	C-C motif chemokine ligand 2	Homo sapiens	54-58
34011067-9	2021	Gene set enrichment analysis identified 3 signaling pathways (extracellular matrix receptor interaction, focal adhesion, and glycosaminoglycan biosynthesis chondroitin sulfate) that were enriched in PDGFA high expression phenotype (all P < .01).PDGFA may serve as an oncogene in ESCC and represent an independent molecular biomarker for prognosis of ESCC patients.	Chondroitin Sulfates	156-175	platelet derived growth factor subunit A	Homo sapiens	199-204
34004196-5	2021	Functionalized with the outer CS shell, TLA/PTX@CS entered MDR breast cancer (MCF-7/MDR) cells via CD44 receptor-mediated endocytosis.	Chondroitin Sulfates	30-32	CD44 molecule (Indian blood group)	Homo sapiens	99-103
33997891-8	2021	For CgA, the glycosylation site carried either CS or HS, making it a so-called hybrid site.	Chondroitin Sulfates	47-49	chromogranin A	Mus musculus	4-7
33957983-1	2021	BACKGROUND: Mucopolysaccharidosis IVA (Morquio A syndrome) is a lysosomal storage disease caused by the deficiency of enzyme N-acetylgalactosamine-6-sulfate sulfatase (GALNS), which results in the accumulation of the glycosaminoglycans (GAGs), keratan sulfate, and chondroitin-6-sulfate in the lysosomes of all tissues causing systemic dysfunction.	Chondroitin Sulfates	265-286	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	168-173
33043980-2	2021	CS from shark cartilage was degraded by a recombinant CS endolyase, chondroitinase ABC I (CHSase ABC I), and CS disaccharide (DP2), tetrasaccharide (DP4), hexasaccharide (DP6), octasaccharide (DP8), decasaccharide (DP10) and dodecasaccharide (DP12) were obtained by separation with gel filtration.	Chondroitin Sulfates	0-2	transcription factor Dp-2	Homo sapiens	126-129
33043980-2	2021	CS from shark cartilage was degraded by a recombinant CS endolyase, chondroitinase ABC I (CHSase ABC I), and CS disaccharide (DP2), tetrasaccharide (DP4), hexasaccharide (DP6), octasaccharide (DP8), decasaccharide (DP10) and dodecasaccharide (DP12) were obtained by separation with gel filtration.	Chondroitin Sulfates	0-2	transcription factor Dp family member 3	Homo sapiens	149-152
33043980-2	2021	CS from shark cartilage was degraded by a recombinant CS endolyase, chondroitinase ABC I (CHSase ABC I), and CS disaccharide (DP2), tetrasaccharide (DP4), hexasaccharide (DP6), octasaccharide (DP8), decasaccharide (DP10) and dodecasaccharide (DP12) were obtained by separation with gel filtration.	Chondroitin Sulfates	0-2	dipeptidyl peptidase 8	Homo sapiens	193-196
4263037-6	1972	Finally, the presence of the UDP-N-acetylgalactosamine-chondroitin 6-sulphate hexasaccharide N-acetylgalactosaminyltransferase previously implicated in chondroitin sulphate biosynthesis was demonstrated in microsomal particles from fractions of purified mast cells.	Chondroitin Sulfates	152-172	beta-1,4-N-acetyl-galactosaminyl transferase 2	Mus musculus	93-126
5795852-0	1969	Actions of insulin and growth hormone on colagen and chondroitin sulfate synthesis in bone organ cultures.	Chondroitin Sulfates	53-72	insulin	Homo sapiens	11-18
5795852-0	1969	Actions of insulin and growth hormone on colagen and chondroitin sulfate synthesis in bone organ cultures.	Chondroitin Sulfates	53-72	growth hormone 1	Homo sapiens	23-37
5647269-0	1968	Formation of three types of disulfated disaccharides from chondroitin sulfates by chondroitinase digestion.	Chondroitin Sulfates	58-78	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	82-96
14072176-1	1963	A macromolecule of protein and chondroitin sulfate (PP-L) inhibits sedimentation of barium-polystyrene sulfonate (BaPSS) and of calcium phosphate at low but not at high values of gravity.	Chondroitin Sulfates	31-50	periplakin	Homo sapiens	52-56
33858569-7	2021	Immunofluorescence staining of liver tissues revealed that CD44, mediated by chondroitin sulfate, delivered the nanoparticles to hepatic stellate cells.	Chondroitin Sulfates	77-96	CD44 antigen	Mus musculus	59-63
34048524-1	2021	The preparation of chondroitin sulfate (CS) oligosaccharide mimetics, more easily synthesized than natural sequences, is a highly interesting task because these compounds pave the way for modulation of the biological processes in which CS is involved.	Chondroitin Sulfates	19-38	citrate synthase	Homo sapiens	40-42
34048524-1	2021	The preparation of chondroitin sulfate (CS) oligosaccharide mimetics, more easily synthesized than natural sequences, is a highly interesting task because these compounds pave the way for modulation of the biological processes in which CS is involved.	Chondroitin Sulfates	19-38	citrate synthase	Homo sapiens	236-238
33320336-5	2021	Here we show that expression of PLPPR1 reduces the inhibition of neurite outgrowth of cultured mouse hippocampal neurons by chondroitin sulfate proteoglycans and the retraction of neurites of Neuro-2a cells by lysophosphatidic acid (LPA).	Chondroitin Sulfates	124-143	phospholipid phosphatase related 1	Mus musculus	32-38
33852594-8	2021	Monolayers of single cultures or co-cultures of hCMEC/D3 cells and astrocytes on fibronectin-coated Rinzl coverslips retained membrane integrities and metabolic function, after freezing in 5% DMSO, 6% HES, and 2% chondroitin sulfate, that were comparable to those of unfrozen controls even after overnight incubation.	Chondroitin Sulfates	213-232	fibronectin 1	Homo sapiens	81-92
33487067-10	2021	CONCLUSIONS: SeCS supplement increased the number of living chondrocytes, improved the ultrastructure, and altered the expressions of CS structure-modifying sulfotransferases, Caspase-9, and Cyt-C.	Chondroitin Sulfates	15-17	caspase 9	Homo sapiens	176-185
33487067-10	2021	CONCLUSIONS: SeCS supplement increased the number of living chondrocytes, improved the ultrastructure, and altered the expressions of CS structure-modifying sulfotransferases, Caspase-9, and Cyt-C.	Chondroitin Sulfates	15-17	cytochrome c, somatic	Homo sapiens	191-196
33340254-5	2021	Intracellular uptake as well as in vivo imaging results revealed the obtained CS-CC/Adr nanoparticles (size of ~100 nm) showed CS mediated tumor specific accumulation into A549 and LLC cells than unmodified CC/Adr, in which the CD44 receptor might be involved, which finally resulted in stronger anticancer capability than Adr or CC/Adr.	Chondroitin Sulfates	78-80	CD44 antigen	Mus musculus	228-232
33908449-3	2021	In this study, a novel CD44 receptor-targeted and redox/ultrasound-responsive oxygen-carrying nanoplatform was constructed using chondroitin sulfate (CS), reactive oxygen species (ROS)-generating sonosensitizer Rhein (Rh), and perfluorocarbon (PFC).	Chondroitin Sulfates	129-148	CD44 antigen	Mus musculus	23-27
33908449-3	2021	In this study, a novel CD44 receptor-targeted and redox/ultrasound-responsive oxygen-carrying nanoplatform was constructed using chondroitin sulfate (CS), reactive oxygen species (ROS)-generating sonosensitizer Rhein (Rh), and perfluorocarbon (PFC).	Chondroitin Sulfates	150-152	CD44 antigen	Mus musculus	23-27
33908449-6	2021	In addition, SDT promoted immunogenic cell death (ICD) by inducing exposure of calreticulin (CRT) after treatment with CS-Rh-PFC nanoparticles (NPs).	Chondroitin Sulfates	119-121	calreticulin	Mus musculus	79-91
33791155-2	2021	Several studies have indicated that abnormal chondroitin sulfate (CS) chains accumulate in breast cancer tissues; however, the functions and dysregulation of CS synthases are largely unknown.	Chondroitin Sulfates	45-64	citrate synthase	Homo sapiens	66-68
33955435-1	2021	Chondroitin sulfate (CS), as a popular material for cartilage tissue engineering scaffolds, has been extensively studied and reported for its safety and excellent biocompatibility.	Chondroitin Sulfates	0-19	citrate synthase	Rattus norvegicus	21-23
33582241-5	2021	CSGalNAcT1, which encodes CS N-acetylgalactosaminyltransferase-1 (T1), a key enzyme for CS biosynthesis, was highly expressed in hematopoietic stem and progenitor cells (HSPCs) and endothelial cells, but not in mesenchymal stromal cells (MSCs) in BM.	Chondroitin Sulfates	26-28	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	0-10
32839819-5	2021	Here, we induced experimental autoimmune encephalomyelitis (EAE) in mice lacking CS N-acetylgalactosaminyltransferase-1 (CSGalNAcT1-KO), an important enzyme for CS synthesis.	Chondroitin Sulfates	81-83	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	121-131
32839819-9	2021	We previously performed EAE experiments in GlcNAc-6-O-sulfotransferase KO (GlcNAc6ST-KO) and C6ST1-KO mice, which had reduced KS and reduced CS-C, respectively.	Chondroitin Sulfates	141-143	carbohydrate sulfotransferase 3	Mus musculus	93-98
33313879-4	2021	PTPRsigma belongs to class 2a RPTP family, dephosphorylates cortactin, and leads to autophagy flux disruption and axonal regeneration inhibition in response to its ligand chondroitin sulfate.	Chondroitin Sulfates	171-190	cortactin	Homo sapiens	60-69
33398638-7	2021	Finally, we investigated the relative expression in astrocytes of CS-PGs of the lectican family of proteins, major components of the brain ECM, in vivo using translating ribosome affinity purification (TRAP) (in Aldh1l1-EGFP-Rpl10a mice.	Chondroitin Sulfates	66-68	aldehyde dehydrogenase 1 family, member L1	Mus musculus	212-219
33506337-1	2021	Chondroitin sulfate (CS) is a widely studied class of glycosaminoglycans, responsible for diverse biological functions.	Chondroitin Sulfates	0-19	citrate synthase	Homo sapiens	21-23
32601684-1	2021	Loss-of-function variants in CHST14 cause a dermatan 4-O-sulfotransferase deficiency named musculocontractural Ehlers-Danlos syndrome-CHST14 (mcEDS-CHST14), resulting in complete depletion of the dermatan sulfate moiety of decorin glycosaminoglycan (GAG) chains, which is replaced by chondroitin sulfate.	Chondroitin Sulfates	284-303	carbohydrate sulfotransferase 14	Mus musculus	29-35
33436222-2	2021	Chondroitin sulfate (CS) was used to construct the nanoparticles due to the ability of tumor targeting through binding with CD44 receptor that overexpresses on the surfaces of various tumor cells.	Chondroitin Sulfates	0-19	CD44 molecule (Indian blood group)	Homo sapiens	124-128
33436222-2	2021	Chondroitin sulfate (CS) was used to construct the nanoparticles due to the ability of tumor targeting through binding with CD44 receptor that overexpresses on the surfaces of various tumor cells.	Chondroitin Sulfates	21-23	CD44 molecule (Indian blood group)	Homo sapiens	124-128
33454424-7	2021	VEGF165 and Indian hedgehog, crucial vasculogenic factors, utilized the versican-hyaluronan matrix, specifically versican chondroitin sulfate chains, for binding.	Chondroitin Sulfates	122-141	versican	Mus musculus	72-80
33454424-7	2021	VEGF165 and Indian hedgehog, crucial vasculogenic factors, utilized the versican-hyaluronan matrix, specifically versican chondroitin sulfate chains, for binding.	Chondroitin Sulfates	122-141	versican	Mus musculus	113-121
33358299-1	2021	We report results on the structure, physicochemical characteristics and purity of chondroitin sulfate (CS) samples derived from three largely available and common biological sources such as bovine and porcine trachea and chicken keel bones with the aim to define their structural signatures.	Chondroitin Sulfates	82-101	citrate synthase	Bos taurus	103-105
33659749-7	2021	Furthermore, the Abcd1-deficient astrocytes produced higher amounts of chondroitin sulfate, a marker of reactive astrocytes.	Chondroitin Sulfates	71-90	ATP-binding cassette, sub-family D (ALD), member 1	Mus musculus	17-22
33538598-1	2021	Chondroitin sulfate (CS), the main component of cartilage extracellular matrix, has attracted attention as a biomaterial for cartilage tissue engineering.	Chondroitin Sulfates	0-19	citrate synthase	Homo sapiens	21-23
33293360-1	2021	Perineuronal nets (PNNs) are an extracellular matrix structure rich in chondroitin sulphate proteoglycans (CSPGs) which preferentially encase parvalbumin-containing (PV+) interneurons.	Chondroitin Sulfates	71-91	parvalbumin	Mus musculus	142-153
33585481-7	2021	Chondroitin sulfates, hyaluronic acid, tenascin-R, and linker proteins comprising the perineuronal net interact with L1-CAMs and NCAM, stabilizing synaptic contacts and limiting plasticity as critical periods close.	Chondroitin Sulfates	0-20	neural cell adhesion molecule 1	Homo sapiens	129-133
33501449-5	2021	Analysis revealed some of the strongest associations of common variants with human phenotypes including height, hair morphology, and biomarkers of human health; for example, a VNTR encoding 13-44 copies of a 19-amino-acid repeat in the chondroitin sulfate domain of aggrecan (ACAN) associated with height variation of 3.4 centimeters (s.e.	Chondroitin Sulfates	236-255	aggrecan	Homo sapiens	276-280
33495490-3	2021	Mice deficient in chondroitin 6-O-sulfotransferase-1 (C6st-1), which is involved in biosynthesis of chondroitin 6-sulfate, exhibited keratinocyte hyperproliferation and impaired skin permeability barrier function.	Chondroitin Sulfates	100-121	carbohydrate sulfotransferase 3	Mus musculus	18-52
33495490-3	2021	Mice deficient in chondroitin 6-O-sulfotransferase-1 (C6st-1), which is involved in biosynthesis of chondroitin 6-sulfate, exhibited keratinocyte hyperproliferation and impaired skin permeability barrier function.	Chondroitin Sulfates	100-121	carbohydrate sulfotransferase 3	Mus musculus	54-60
33495490-5	2021	Normal function of hyperproliferative C6st-1-knockout mouse-derived keratinocytes was rescued by treatment with exogenous chondroitin 6-sulfate.	Chondroitin Sulfates	122-143	carbohydrate sulfotransferase 3	Mus musculus	38-44
33478164-0	2021	Deciphering Structural Determinants in Chondroitin Sulfate Binding to FGF-2: Paving the Way to Enhanced Predictability of their Biological Functions.	Chondroitin Sulfates	39-58	fibroblast growth factor 2	Homo sapiens	70-75
33459997-0	2021	Probiotic Composition and Chondroitin Sulfate Regulate TLR-2/4-Mediated NF-kappaB Inflammatory Pathway and Cartilage Metabolism in Experimental Osteoarthritis.	Chondroitin Sulfates	26-45	toll like receptor 2	Homo sapiens	55-62
33459997-0	2021	Probiotic Composition and Chondroitin Sulfate Regulate TLR-2/4-Mediated NF-kappaB Inflammatory Pathway and Cartilage Metabolism in Experimental Osteoarthritis.	Chondroitin Sulfates	26-45	nuclear factor kappa B subunit 1	Homo sapiens	72-81
33459997-2	2021	The aim of this study was to describe the effect of a probiotic composition (PB) and chondroitin sulfate (CS), administered separately or in combination, on Tlr2, Tlr4, Nfkb1, and Comp gene expression in cartilage and levels of cytokines (IL-6, IL-8, TGF-beta1, IGF-1) and COMP, ACAN, CHI3L1, CTSK, and TLR-2 in serum during monoiodoacetate (MIA)-induced OA in rats.	Chondroitin Sulfates	85-104	toll-like receptor 2	Rattus norvegicus	157-161
33459997-2	2021	The aim of this study was to describe the effect of a probiotic composition (PB) and chondroitin sulfate (CS), administered separately or in combination, on Tlr2, Tlr4, Nfkb1, and Comp gene expression in cartilage and levels of cytokines (IL-6, IL-8, TGF-beta1, IGF-1) and COMP, ACAN, CHI3L1, CTSK, and TLR-2 in serum during monoiodoacetate (MIA)-induced OA in rats.	Chondroitin Sulfates	85-104	toll-like receptor 4	Rattus norvegicus	163-167
33459997-2	2021	The aim of this study was to describe the effect of a probiotic composition (PB) and chondroitin sulfate (CS), administered separately or in combination, on Tlr2, Tlr4, Nfkb1, and Comp gene expression in cartilage and levels of cytokines (IL-6, IL-8, TGF-beta1, IGF-1) and COMP, ACAN, CHI3L1, CTSK, and TLR-2 in serum during monoiodoacetate (MIA)-induced OA in rats.	Chondroitin Sulfates	85-104	cartilage oligomeric matrix protein	Rattus norvegicus	180-184
33511110-1	2020	Chondroitin sulfate (CS) is an important component of the extracellular matrix in multiple biological tissues.	Chondroitin Sulfates	0-19	citrate synthase	Homo sapiens	21-23
33452387-3	2021	Immunohistochemical analysis of autopsy specimens from a patient with MMD revealed marked accumulation of hyaluronan and chondroitin sulfate (CS) in the thickened intima of occlusive lesions of MMD.	Chondroitin Sulfates	121-140	citrate synthase	Homo sapiens	142-144
33436038-0	2021	Nerve growth factor-chondroitin sulfate/hydroxyapatite-coating composite implant induces early osseointegration and nerve regeneration of peri-implant tissues in Beagle dogs.	Chondroitin Sulfates	20-39	nerve growth factor	Canis lupus familiaris	0-19
33436038-3	2021	However, the influence of NGF-chondroitin sulfate (CS)/hydroxyapatite (HA)-coating composite implant on the osseointegration and innervations is still not entirely clear.	Chondroitin Sulfates	30-49	nerve growth factor	Canis lupus familiaris	26-29
33604385-2	2021	Versican (VCAN) is a chondroitin sulfate proteoglycan which is important for tumorigenesis and the development of cancer.	Chondroitin Sulfates	21-40	versican	Homo sapiens	0-8
33604385-2	2021	Versican (VCAN) is a chondroitin sulfate proteoglycan which is important for tumorigenesis and the development of cancer.	Chondroitin Sulfates	21-40	versican	Homo sapiens	10-14
33456569-11	2021	In addition, SRGN interacted with MDK and matrix metalloproteinase 2 in ESCC via its GAG chains, which were mainly decorated with chondroitin sulfate comprising of  di-4S and  di-6S CS.	Chondroitin Sulfates	130-149	serglycin	Homo sapiens	13-17
33442722-1	2021	Mammalian hyaluronidases are endo-N-acetyl-D-hexosaminidases involved in the catabolism of hyaluronic acid (HA) but their role in the catabolism of chondroitin sulfate (CS) is also examined.	Chondroitin Sulfates	148-167	citrate synthase	Homo sapiens	169-171
33142641-1	2021	The polysaccharide-based biomaterials hyaluronic acid (HA) and chondroitin sulfate (CS) have aroused great interest for use in drug delivery systems for tumor therapy, as they have outstanding biocompatibility and great targeting ability for cluster determinant 44 (CD44).	Chondroitin Sulfates	63-82	citrate synthase	Homo sapiens	84-86
33403027-9	2021	Moreover, gene set enrichment analysis showed that cases of HNSCC with FOXD1 overexpression were enriched in bladder cancer, cell cycle, DNA replication, glycosaminoglycan biosynthesis chondroitin sulfate, homologous recombination, glycan biosynthesis, nucleotide excision repair, p53 signaling pathway, pyrimidine metabolism, and spliceosome pathways.	Chondroitin Sulfates	185-204	forkhead box D1	Homo sapiens	71-76
33185866-0	2021	Inhibition of Chondroitin Sulfate Proteoglycans by APRIL.	Chondroitin Sulfates	14-33	TNF superfamily member 13	Homo sapiens	51-56
33049840-3	2020	Cell cytotoxicity, cell viability and intracellular uptake study on differentiated U937 and MG-63 cells demonstrated the active targeting of CS-TEF-LIPO towards CD44 receptors.	Chondroitin Sulfates	141-143	CD44 molecule (Indian blood group)	Homo sapiens	161-165
33380731-6	2020	We found that intense removal of chondroitin sulfate (CS) and dermatan sulfate chains by chondroitinase ABC reduced the speed and decreased the strength of adhesion of HeLa cells.	Chondroitin Sulfates	33-52	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	89-103
33380731-6	2020	We found that intense removal of chondroitin sulfate (CS) and dermatan sulfate chains by chondroitinase ABC reduced the speed and decreased the strength of adhesion of HeLa cells.	Chondroitin Sulfates	54-56	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	89-103
33339362-8	2020	The dysregulation of spinal chondroitin sulfate proteoglycans was observed in SOD1G93A rats at the terminal stage.	Chondroitin Sulfates	28-47	superoxide dismutase 1	Rattus norvegicus	78-82
33605133-2	2021	One of the promising areas of pharmacotherapy for degenerative-dystrophic joint lesions is the use of chondroprotectors (CP), in particular chondroitin sulfate (CS).	Chondroitin Sulfates	140-159	citrate synthase	Homo sapiens	161-163
33297347-1	2020	It has recently been demonstrated that chronic supplementation with nonanimal chondroitin sulfate (nonanimal CS) in overweight subjects with knee osteoarthritis (OA) improves the function, pain and inflammation, but there are no studies of its effectiveness in an acute setting.	Chondroitin Sulfates	78-97	citrate synthase	Homo sapiens	109-111
32330934-9	2020	In vitro, the c-kitpos/CD45neg/CD31neg myxoma cells secrete chondroitin-6-sulfate and hyaluronic acid, which are the main components of gelatinous myxoma matrix in vivo.	Chondroitin Sulfates	60-81	platelet and endothelial cell adhesion molecule 1	Homo sapiens	31-35
32745937-1	2020	The impact of glycosaminoglycan (chondroitin sulphate, CS) on bone morphogenetic protein - 2 (BMP - 2) structure, stability (thermal and chemical), association kinetics and conformation was monitored by multiple spectroscopic techniques (UV-Visible, fluorescence and circular dichroism).	Chondroitin Sulfates	33-53	bone morphogenetic protein 2	Homo sapiens	62-92
33425887-1	2020	Chondroitin sulfate (CS) and dermatan sulfate (DS) are widely distributed on the cell surface and in the extracellular matrix in the form of proteoglycan, where they participate in various biological processes.	Chondroitin Sulfates	0-19	citrate synthase	Homo sapiens	21-23
32623935-2	2020	An important feature of syndecan-1 related to its role in pathologies is that it can be shed from the surface of cells as an intact ectodomain composed of the extracellular core protein and attached heparan sulfate and chondroitin sulfate chains.	Chondroitin Sulfates	219-238	syndecan 1	Homo sapiens	24-34
33390680-1	2020	Morquio syndrome is caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS) enzyme, which is required for the catabolism of glycosaminoglycans (namely, chondroitin-6-sulfate and keratan sulfate).	Chondroitin Sulfates	174-195	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	91-96
33002580-2	2020	In this study, we showed the effect of biglycan (Bgn), a small leucine-rich proteoglycan enriched in extracellular matrix of bone and the associated GAG subtype, chondroitin sulfate (CS), on the toughness of bone in vivo, using wild-type (WT) and Bgn deficient mice.	Chondroitin Sulfates	162-181	biglycan	Mus musculus	39-47
33002580-2	2020	In this study, we showed the effect of biglycan (Bgn), a small leucine-rich proteoglycan enriched in extracellular matrix of bone and the associated GAG subtype, chondroitin sulfate (CS), on the toughness of bone in vivo, using wild-type (WT) and Bgn deficient mice.	Chondroitin Sulfates	162-181	biglycan	Mus musculus	49-52
33002580-2	2020	In this study, we showed the effect of biglycan (Bgn), a small leucine-rich proteoglycan enriched in extracellular matrix of bone and the associated GAG subtype, chondroitin sulfate (CS), on the toughness of bone in vivo, using wild-type (WT) and Bgn deficient mice.	Chondroitin Sulfates	183-185	biglycan	Mus musculus	39-47
33002580-2	2020	In this study, we showed the effect of biglycan (Bgn), a small leucine-rich proteoglycan enriched in extracellular matrix of bone and the associated GAG subtype, chondroitin sulfate (CS), on the toughness of bone in vivo, using wild-type (WT) and Bgn deficient mice.	Chondroitin Sulfates	183-185	biglycan	Mus musculus	49-52
33002580-3	2020	The amount of total GAGs and CS in the mineralized compartment of Bgn KO mouse bone matrix decreased significantly, associated with the reduction of the toughness of bone, in comparison with those of WT mice.	Chondroitin Sulfates	29-31	biglycan	Mus musculus	66-69
33023972-3	2020	Using Gnptg ko mice as a model of the human disease, we showed that missorting of a number of lysosomal enzymes is associated with intracellular accumulation of chondroitin sulfate in Gnptg ko chondrocytes and their impaired differentiation, as well as with an altered microstructure of the cartilage extracellular matrix (ECM).	Chondroitin Sulfates	161-180	N-acetylglucosamine-1-phosphotransferase, gamma subunit	Mus musculus	6-11
33424274-0	2020	Developed simvastatin chitosan nanoparticles co-crosslinked with tripolyphosphate and chondroitin sulfate for ASGPR-mediated targeted HCC delivery with enhanced oral bioavailability.	Chondroitin Sulfates	86-105	asialoglycoprotein receptor 1	Homo sapiens	110-115
33023972-3	2020	Using Gnptg ko mice as a model of the human disease, we showed that missorting of a number of lysosomal enzymes is associated with intracellular accumulation of chondroitin sulfate in Gnptg ko chondrocytes and their impaired differentiation, as well as with an altered microstructure of the cartilage extracellular matrix (ECM).	Chondroitin Sulfates	161-180	N-acetylglucosamine-1-phosphate transferase subunit gamma	Homo sapiens	184-189
32919534-1	2020	Chondroitin sulfate (CS) is one of the major and widespread glycosaminoglycans, a family of structurally complex, linear, anionic hetero-co-polysaccharides.	Chondroitin Sulfates	0-19	citrate synthase	Homo sapiens	21-23
33149218-5	2020	We found that versican, a large chondroitin sulfate PG, promotes collagen fibrillogenesis in a turbidity assay and upregulates cell-mediated collagen compaction and reorganization, whereas aggrecan, a structurally-similar large PG, has different and often opposing effects on collagen.	Chondroitin Sulfates	32-51	versican	Homo sapiens	14-22
33187224-6	2020	Furthermore, we report the ability of chondroitin sulphate C to bind EDIII and induce higher-order dynamic molecular changes at the tertiary and quaternary structure levels which are dependent on pH, GAG species, and the GAG sulphation state.	Chondroitin Sulfates	38-58	phenylalanine hydroxylase	Homo sapiens	196-198
32954487-1	2020	INTRODUCTION: The recent CONCEPT study showed that 800 mg/day of pharmaceutical-grade chondroitin sulfate (CS) was superior to placebo and similar to celecoxib in reducing pain and improving function over 6 months in patients with symptomatic knee osteoarthritis (OA).	Chondroitin Sulfates	86-105	citrate synthase	Homo sapiens	107-109
32700771-1	2020	Bikunin (Bkn) isoforms are serum chondroitin sulfate proteoglycans synthesized by the liver.	Chondroitin Sulfates	33-52	alpha-1-microglobulin/bikunin precursor	Homo sapiens	0-7
32731916-4	2020	ECM is composed of diverse components including several proteins and polysaccharide chains such as chondroitin sulfate, heparan sulfate, and hyaluronic acid.	Chondroitin Sulfates	99-118	multimerin 1	Homo sapiens	0-3
33131383-1	2020	Versican is a large chondroitin sulfate/dermatan sulfate proteoglycan belonging to the aggrecan/lectican family.	Chondroitin Sulfates	20-39	versican	Homo sapiens	0-8
31461788-10	2020	Finally, chondroitin sulfate (CHS), as functional component of DMP1-PG, was employed to test whether it could delay the premature suture fusion and the abnormal differentiation of bone mesenchymal stem cells (BMSCs) of DMP1-PG mice.	Chondroitin Sulfates	9-28	dentin matrix protein 1	Mus musculus	63-67
31461788-14	2020	Finally, chondroitin sulfate, major component of DMP1-PG, successfully delayed the premature suture fusion by organ culture of skull in vitro.	Chondroitin Sulfates	9-28	dentin matrix protein 1	Mus musculus	49-56
32700771-1	2020	Bikunin (Bkn) isoforms are serum chondroitin sulfate proteoglycans synthesized by the liver.	Chondroitin Sulfates	33-52	alpha-1-microglobulin/bikunin precursor	Homo sapiens	9-12
33143303-0	2020	Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice.	Chondroitin Sulfates	60-79	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	23-36
33143303-2	2020	CS chains in PNNs control neuronal plasticity by binding to PNN effectors, semaphorin-3A (Sema3A) and orthodenticle homeobox 2.	Chondroitin Sulfates	0-2	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	75-88
33143303-2	2020	CS chains in PNNs control neuronal plasticity by binding to PNN effectors, semaphorin-3A (Sema3A) and orthodenticle homeobox 2.	Chondroitin Sulfates	0-2	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	90-96
33143303-2	2020	CS chains in PNNs control neuronal plasticity by binding to PNN effectors, semaphorin-3A (Sema3A) and orthodenticle homeobox 2.	Chondroitin Sulfates	0-2	orthodenticle homeobox 2	Mus musculus	102-126
33143303-3	2020	Sema3A recognizes CS-containing type-E disaccharide units (sulfated at O-4 and O-6 of N-acetylgalactosamine).	Chondroitin Sulfates	18-20	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	0-6
33143303-7	2020	Therefore, we re-examined the Sema3A binding motif found in CS chains using chemically synthesized CS tetrasaccharides.	Chondroitin Sulfates	60-62	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	30-36
33143303-8	2020	As a result, we found that non-sulfated GalNAc residues at the non-reducing termini of CS chains are required for the binding of Sema3A.	Chondroitin Sulfates	87-89	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	129-135
33163701-4	2021	The HA-CS hydrogels were optimized with suitable biophysical properties by fine-tuning degree of thiol group substitution to support C2C12 myoblast proliferation, myogenic differentiation and expression of myogenic markers MyoD, MyoG and MYH8.	Chondroitin Sulfates	7-9	myogenic differentiation 1	Mus musculus	223-227
33163701-4	2021	The HA-CS hydrogels were optimized with suitable biophysical properties by fine-tuning degree of thiol group substitution to support C2C12 myoblast proliferation, myogenic differentiation and expression of myogenic markers MyoD, MyoG and MYH8.	Chondroitin Sulfates	7-9	myogenin	Mus musculus	229-233
33163701-4	2021	The HA-CS hydrogels were optimized with suitable biophysical properties by fine-tuning degree of thiol group substitution to support C2C12 myoblast proliferation, myogenic differentiation and expression of myogenic markers MyoD, MyoG and MYH8.	Chondroitin Sulfates	7-9	myosin, heavy polypeptide 8, skeletal muscle, perinatal	Mus musculus	238-242
33163701-5	2021	Furthermore, in vivo studies using a murine quadriceps VML model demonstrated that the HA-CS hydrogels supported integration of implants with the surrounding host tissue and facilitated migration of Pax7+ satellite cells, de novo myofiber formation, angiogenesis, and innervation with minimized scar tissue formation during 4-week implantation.	Chondroitin Sulfates	90-92	paired box 7	Mus musculus	199-203
33036643-0	2020	Inhibition of hypertrophy and improving chondrocyte differentiation by MMP-13 inhibitor small molecule encapsulated in alginate-chondroitin sulfate-platelet lysate hydrogel.	Chondroitin Sulfates	128-147	matrix metallopeptidase 13	Homo sapiens	71-77
33026610-0	2021	Chondroitin sulfate conjugation facilitates tumor cell internalization of albumin nanoparticles for brain-targeted delivery of temozolomide via CD44 receptor-mediated targeting.	Chondroitin Sulfates	0-19	CD44 molecule (Indian blood group)	Homo sapiens	144-148
32818610-4	2020	Inspired by the CD44-mediated tumor targeting effect of the hydrophilic polysaccharide chondroitin sulphate (ChS), we chemically synthesized amphiphilic zein-ChS micelles.	Chondroitin Sulfates	87-107	CD44 molecule (Indian blood group)	Homo sapiens	16-20
33028117-1	2021	PURPOSE: To determine alterations of chondroitin sulfate (CS) that reflect cartilage damage in an experimental osteoarthritis (OA) model as well as in human OA samples.	Chondroitin Sulfates	37-56	citrate synthase	Homo sapiens	58-60
32388727-1	2020	Syndecan-1, is a transmembrane heparan/chondroitin sulfate proteoglycan necessary for cell-cell and cell-matrix interactions.	Chondroitin Sulfates	39-58	syndecan 1	Homo sapiens	0-10
31994025-1	2020	Mucopolysaccharidosis IVA (Morquio A disease) is a genetic disorder caused by deficiency of N-acetylgalactosamine-6-sulfate-sulfatase (GALNS), leading to accumulation of keratan sulfate and chondroitin-6-sulfate in lysosomes.	Chondroitin Sulfates	190-211	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	135-140
32854301-1	2020	The VCAN/versican gene encodes an important component of the extracellular matrix, the chondroitin sulfate proteoglycan 2 (CSPG2/versican).	Chondroitin Sulfates	87-106	versican	Homo sapiens	4-8
32869084-1	2020	A capillary electrophoresis (CE) method combined with online and offline enrichment for improving the detection sensitivity of chondroitin sulfate (CS) is established.	Chondroitin Sulfates	127-146	citrate synthase	Homo sapiens	148-150
32856704-0	2020	Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate.	Chondroitin Sulfates	114-133	arylsulfatase K	Mus musculus	0-15
32856704-4	2020	Recently, we identified and characterized the lysosomal enzyme arylsulfatase K (Arsk) exhibiting glucuronate-2-sulfatase activity as needed for the degradation of heparan sulfate (HS), chondroitin sulfate (CS) and dermatan sulfate (DS).	Chondroitin Sulfates	185-204	arylsulfatase K	Mus musculus	63-78
32856704-4	2020	Recently, we identified and characterized the lysosomal enzyme arylsulfatase K (Arsk) exhibiting glucuronate-2-sulfatase activity as needed for the degradation of heparan sulfate (HS), chondroitin sulfate (CS) and dermatan sulfate (DS).	Chondroitin Sulfates	185-204	arylsulfatase K	Mus musculus	80-84
32856704-4	2020	Recently, we identified and characterized the lysosomal enzyme arylsulfatase K (Arsk) exhibiting glucuronate-2-sulfatase activity as needed for the degradation of heparan sulfate (HS), chondroitin sulfate (CS) and dermatan sulfate (DS).	Chondroitin Sulfates	206-208	arylsulfatase K	Mus musculus	63-78
32856704-4	2020	Recently, we identified and characterized the lysosomal enzyme arylsulfatase K (Arsk) exhibiting glucuronate-2-sulfatase activity as needed for the degradation of heparan sulfate (HS), chondroitin sulfate (CS) and dermatan sulfate (DS).	Chondroitin Sulfates	206-208	arylsulfatase K	Mus musculus	80-84
32856704-7	2020	Arsk-deficient mice show, in an organ-specific manner, a moderate accumulation of HS and CS metabolites characterized by 2-O-sulfated glucuronate moieties at their non-reducing ends.	Chondroitin Sulfates	89-91	arylsulfatase K	Mus musculus	0-4
32982340-1	2020	Background: Chondroitin sulfate, alone or associated with glucosamine (CS), is an effective treatment of osteoarthritis, better tolerated than non-steroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase 2 inhibitors (COXIBs) at gastrointestinal, cardiovascular and renal levels.	Chondroitin Sulfates	12-31	citrate synthase	Homo sapiens	71-73
32800841-6	2020	These effects were selectively phenocopied by altered expression of kon-tiki (kon), a chondroitin sulfate proteoglycan 4/NG2 homologue and a central component of MTJ formation.	Chondroitin Sulfates	86-105	kon-tiki	Drosophila melanogaster	68-76
32800841-6	2020	These effects were selectively phenocopied by altered expression of kon-tiki (kon), a chondroitin sulfate proteoglycan 4/NG2 homologue and a central component of MTJ formation.	Chondroitin Sulfates	86-105	kon-tiki	Drosophila melanogaster	68-71
32480094-10	2020	Increasing CS concentration promoted upregulated vimentin expression in PC-3 cultures and N-cadherin and MMP-2 expression in 22Rv1 cultures.	Chondroitin Sulfates	11-13	vimentin	Homo sapiens	49-57
32480094-10	2020	Increasing CS concentration promoted upregulated vimentin expression in PC-3 cultures and N-cadherin and MMP-2 expression in 22Rv1 cultures.	Chondroitin Sulfates	11-13	cadherin 2	Homo sapiens	90-100
32480094-10	2020	Increasing CS concentration promoted upregulated vimentin expression in PC-3 cultures and N-cadherin and MMP-2 expression in 22Rv1 cultures.	Chondroitin Sulfates	11-13	matrix metallopeptidase 2	Homo sapiens	105-110
32315540-2	2020	Inflammation and fibrosis are important processes in liver responses to injury and it has been suggested that they and dual ERA-induced liver injury are mediated by the proteoglycan component chondroitin sulfate (CS), which is synthesized by CHST3 and CHST13.	Chondroitin Sulfates	192-211	carbohydrate sulfotransferase 3	Homo sapiens	242-247
32315540-2	2020	Inflammation and fibrosis are important processes in liver responses to injury and it has been suggested that they and dual ERA-induced liver injury are mediated by the proteoglycan component chondroitin sulfate (CS), which is synthesized by CHST3 and CHST13.	Chondroitin Sulfates	192-211	carbohydrate sulfotransferase 13	Homo sapiens	252-258
32315540-2	2020	Inflammation and fibrosis are important processes in liver responses to injury and it has been suggested that they and dual ERA-induced liver injury are mediated by the proteoglycan component chondroitin sulfate (CS), which is synthesized by CHST3 and CHST13.	Chondroitin Sulfates	213-215	carbohydrate sulfotransferase 3	Homo sapiens	242-247
32315540-2	2020	Inflammation and fibrosis are important processes in liver responses to injury and it has been suggested that they and dual ERA-induced liver injury are mediated by the proteoglycan component chondroitin sulfate (CS), which is synthesized by CHST3 and CHST13.	Chondroitin Sulfates	213-215	carbohydrate sulfotransferase 13	Homo sapiens	252-258
32315540-7	2020	These observations suggest that CHST3 and CHST13-induced CS production can mediate liver injury responses caused by dual ER inhibition, thus could be an alternative pathway for treating ERA-induced liver injury.	Chondroitin Sulfates	57-59	carbohydrate sulfotransferase 13	Homo sapiens	42-48
32854301-1	2020	The VCAN/versican gene encodes an important component of the extracellular matrix, the chondroitin sulfate proteoglycan 2 (CSPG2/versican).	Chondroitin Sulfates	87-106	versican	Homo sapiens	9-17
32854301-1	2020	The VCAN/versican gene encodes an important component of the extracellular matrix, the chondroitin sulfate proteoglycan 2 (CSPG2/versican).	Chondroitin Sulfates	87-106	versican	Homo sapiens	123-128
32854301-1	2020	The VCAN/versican gene encodes an important component of the extracellular matrix, the chondroitin sulfate proteoglycan 2 (CSPG2/versican).	Chondroitin Sulfates	87-106	versican	Homo sapiens	129-137
32722636-5	2020	After CS treatment, bone histomorphometric parameters returned to normal, the levels of serum inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) decreased significantly, serum SOD, GPX and CAT activities increased and MDA level increased.	Chondroitin Sulfates	6-8	catalase	Rattus norvegicus	192-195
32641498-0	2020	Reelin counteracts chondroitin sulfate proteoglycan-mediated cortical dendrite growth inhibition.	Chondroitin Sulfates	19-38	reelin	Homo sapiens	0-6
32722636-0	2020	Chondroitin Sulfate Prevents STZ Induced Diabetic Osteoporosis through Decreasing Blood Glucose, AntiOxidative Stress, Anti-Inflammation and OPG/RANKL Expression Regulation.	Chondroitin Sulfates	0-19	TNF receptor superfamily member 11B	Rattus norvegicus	141-144
32911644-5	2020	In co-culture experiments, rat primary astrocytes pretreated with alpha-synuclein inhibited the growth of neurites of co-cultured primary rat neurons and upregulated chondroitin sulphate proteoglycan.	Chondroitin Sulfates	166-186	synuclein alpha	Rattus norvegicus	66-81
32790806-5	2020	RESULTS: Chondrogenesis in MSCs was consistently and strongly induced in collagen I hydrogels by the transgenes SOX9, TGFB1 and BMP2 as evidenced by positive staining for proteoglycans, chondroitin-4-sulfate (CS4) and collagen (COL) type II, increased levels of glycosaminoglycan (GAG) synthesis, and expression of mRNAs associated with chondrogenesis.	Chondroitin Sulfates	186-207	SRY-box transcription factor 9	Homo sapiens	112-116
32790806-5	2020	RESULTS: Chondrogenesis in MSCs was consistently and strongly induced in collagen I hydrogels by the transgenes SOX9, TGFB1 and BMP2 as evidenced by positive staining for proteoglycans, chondroitin-4-sulfate (CS4) and collagen (COL) type II, increased levels of glycosaminoglycan (GAG) synthesis, and expression of mRNAs associated with chondrogenesis.	Chondroitin Sulfates	186-207	bone morphogenetic protein 2	Homo sapiens	128-132
32512215-7	2020	In contrast to nestin, the percentage of microtubule associated protein 2 (MAP2+) neurons was greater in scaffolds containing, CS, HA or CS-HA, compared to Coll alone.	Chondroitin Sulfates	127-129	microtubule associated protein 2	Homo sapiens	41-73
32512215-7	2020	In contrast to nestin, the percentage of microtubule associated protein 2 (MAP2+) neurons was greater in scaffolds containing, CS, HA or CS-HA, compared to Coll alone.	Chondroitin Sulfates	127-129	microtubule associated protein 2	Homo sapiens	75-79
32512215-7	2020	In contrast to nestin, the percentage of microtubule associated protein 2 (MAP2+) neurons was greater in scaffolds containing, CS, HA or CS-HA, compared to Coll alone.	Chondroitin Sulfates	137-139	microtubule associated protein 2	Homo sapiens	41-73
32512215-7	2020	In contrast to nestin, the percentage of microtubule associated protein 2 (MAP2+) neurons was greater in scaffolds containing, CS, HA or CS-HA, compared to Coll alone.	Chondroitin Sulfates	137-139	microtubule associated protein 2	Homo sapiens	75-79
32722636-0	2020	Chondroitin Sulfate Prevents STZ Induced Diabetic Osteoporosis through Decreasing Blood Glucose, AntiOxidative Stress, Anti-Inflammation and OPG/RANKL Expression Regulation.	Chondroitin Sulfates	0-19	TNF superfamily member 11	Rattus norvegicus	145-150
32722636-5	2020	After CS treatment, bone histomorphometric parameters returned to normal, the levels of serum inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) decreased significantly, serum SOD, GPX and CAT activities increased and MDA level increased.	Chondroitin Sulfates	6-8	interleukin 1 alpha	Rattus norvegicus	118-126
32722636-6	2020	In the CS-treated group, the levels of serum ALP, CTX-1, TRACP 5b, osteocalcin and RANKL decreased and the serum RUNX 2 and OPG levels increased.	Chondroitin Sulfates	7-9	PDZ and LIM domain 3	Rattus norvegicus	45-48
32722636-5	2020	After CS treatment, bone histomorphometric parameters returned to normal, the levels of serum inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) decreased significantly, serum SOD, GPX and CAT activities increased and MDA level increased.	Chondroitin Sulfates	6-8	interleukin 6	Rattus norvegicus	128-132
32722636-5	2020	After CS treatment, bone histomorphometric parameters returned to normal, the levels of serum inflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) decreased significantly, serum SOD, GPX and CAT activities increased and MDA level increased.	Chondroitin Sulfates	6-8	tumor necrosis factor	Rattus norvegicus	137-146
32722636-6	2020	In the CS-treated group, the levels of serum ALP, CTX-1, TRACP 5b, osteocalcin and RANKL decreased and the serum RUNX 2 and OPG levels increased.	Chondroitin Sulfates	7-9	bone gamma-carboxyglutamate protein	Rattus norvegicus	67-78
32722636-6	2020	In the CS-treated group, the levels of serum ALP, CTX-1, TRACP 5b, osteocalcin and RANKL decreased and the serum RUNX 2 and OPG levels increased.	Chondroitin Sulfates	7-9	TNF superfamily member 11	Rattus norvegicus	83-88
32722636-6	2020	In the CS-treated group, the levels of serum ALP, CTX-1, TRACP 5b, osteocalcin and RANKL decreased and the serum RUNX 2 and OPG levels increased.	Chondroitin Sulfates	7-9	RUNX family transcription factor 2	Rattus norvegicus	113-119
32722636-6	2020	In the CS-treated group, the levels of serum ALP, CTX-1, TRACP 5b, osteocalcin and RANKL decreased and the serum RUNX 2 and OPG levels increased.	Chondroitin Sulfates	7-9	TNF receptor superfamily member 11B	Rattus norvegicus	124-127
32722636-7	2020	Bone immunohistochemistry results showed that CS can effectively increase the expression of OPG and RUNX2 and reduce the expression of RANKL in diabetic rats.	Chondroitin Sulfates	46-48	TNF receptor superfamily member 11B	Rattus norvegicus	92-95
32722636-7	2020	Bone immunohistochemistry results showed that CS can effectively increase the expression of OPG and RUNX2 and reduce the expression of RANKL in diabetic rats.	Chondroitin Sulfates	46-48	RUNX family transcription factor 2	Rattus norvegicus	100-105
32722636-7	2020	Bone immunohistochemistry results showed that CS can effectively increase the expression of OPG and RUNX2 and reduce the expression of RANKL in diabetic rats.	Chondroitin Sulfates	46-48	TNF superfamily member 11	Rattus norvegicus	135-140
32722636-8	2020	All of these indicate that CS could prevent STZ induced diabetic osteoporosis-mainly through decreasing blood glucose, antioxidative stress, anti-inflammation and regulation of OPG/RANKL expression.	Chondroitin Sulfates	27-29	TNF receptor superfamily member 11B	Rattus norvegicus	177-180
32722636-8	2020	All of these indicate that CS could prevent STZ induced diabetic osteoporosis-mainly through decreasing blood glucose, antioxidative stress, anti-inflammation and regulation of OPG/RANKL expression.	Chondroitin Sulfates	27-29	TNF superfamily member 11	Rattus norvegicus	181-186
32367292-4	2020	SPR analysis proved early-glycated albumin could interact with the RAGE ectodomain with a steady-state affinity constant of 6.05 +- 0.96 x 10-7 M. Such interaction was shown to be specific, as confirmed by a displacement assay with chondroitin sulfate, a known RAGE binder.	Chondroitin Sulfates	232-251	advanced glycosylation end-product specific receptor	Homo sapiens	67-71
32708378-1	2020	Methacrylated hyaluronic acid (MeHA) and chondroitin sulfate (CS)-biofunctionalized MeHA (CS-MeHA), were crosslinked in the presence of a matrix metalloproteinase 7 (MMP7)-sensitive peptide.	Chondroitin Sulfates	41-60	matrix metallopeptidase 7	Homo sapiens	138-164
32708378-1	2020	Methacrylated hyaluronic acid (MeHA) and chondroitin sulfate (CS)-biofunctionalized MeHA (CS-MeHA), were crosslinked in the presence of a matrix metalloproteinase 7 (MMP7)-sensitive peptide.	Chondroitin Sulfates	41-60	matrix metallopeptidase 7	Homo sapiens	166-170
32367292-4	2020	SPR analysis proved early-glycated albumin could interact with the RAGE ectodomain with a steady-state affinity constant of 6.05 +- 0.96 x 10-7 M. Such interaction was shown to be specific, as confirmed by a displacement assay with chondroitin sulfate, a known RAGE binder.	Chondroitin Sulfates	232-251	advanced glycosylation end-product specific receptor	Homo sapiens	261-265
32612115-1	2020	Chondroitin polymerizing factor (CHPF) is an important member of glycosyltransferases involved in the biosynthesis of chondroitin sulfate (CS).	Chondroitin Sulfates	118-137	chondroitin polymerizing factor	Homo sapiens	0-31
32708378-1	2020	Methacrylated hyaluronic acid (MeHA) and chondroitin sulfate (CS)-biofunctionalized MeHA (CS-MeHA), were crosslinked in the presence of a matrix metalloproteinase 7 (MMP7)-sensitive peptide.	Chondroitin Sulfates	62-64	matrix metallopeptidase 7	Homo sapiens	138-164
32612115-1	2020	Chondroitin polymerizing factor (CHPF) is an important member of glycosyltransferases involved in the biosynthesis of chondroitin sulfate (CS).	Chondroitin Sulfates	118-137	chondroitin polymerizing factor	Homo sapiens	33-37
32612115-1	2020	Chondroitin polymerizing factor (CHPF) is an important member of glycosyltransferases involved in the biosynthesis of chondroitin sulfate (CS).	Chondroitin Sulfates	139-141	chondroitin polymerizing factor	Homo sapiens	0-31
32612115-1	2020	Chondroitin polymerizing factor (CHPF) is an important member of glycosyltransferases involved in the biosynthesis of chondroitin sulfate (CS).	Chondroitin Sulfates	139-141	chondroitin polymerizing factor	Homo sapiens	33-37
32302771-1	2020	Carbohydrate sulfotransferases 11 (chst11) is one of the enzymes that synthesize chondroitin sulfate (CS), which has extensive immune functions in vitro and plays a critical role in mediating the infection of host by pathogenic microorganisms.	Chondroitin Sulfates	81-100	carbohydrate sulfotransferase 11	Homo sapiens	35-41
32094233-2	2020	Chondroitin sulfate proteoglycans, including CD44, regulate cancer progression; however, the identity of a chondroitinase (Chase) that cleaves chondroitin sulfate from proteoglycans is unknown.	Chondroitin Sulfates	0-19	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	123-128
32094233-2	2020	Chondroitin sulfate proteoglycans, including CD44, regulate cancer progression; however, the identity of a chondroitinase (Chase) that cleaves chondroitin sulfate from proteoglycans is unknown.	Chondroitin Sulfates	143-162	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	107-121
32094233-2	2020	Chondroitin sulfate proteoglycans, including CD44, regulate cancer progression; however, the identity of a chondroitinase (Chase) that cleaves chondroitin sulfate from proteoglycans is unknown.	Chondroitin Sulfates	143-162	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	123-128
32094233-11	2020	V1 cleaved chondroitin-6-sulfate from CD44, increasing CD44 secretion.	Chondroitin Sulfates	11-32	CD44 molecule (Indian blood group)	Homo sapiens	38-42
32094233-11	2020	V1 cleaved chondroitin-6-sulfate from CD44, increasing CD44 secretion.	Chondroitin Sulfates	11-32	CD44 molecule (Indian blood group)	Homo sapiens	55-59
32302771-1	2020	Carbohydrate sulfotransferases 11 (chst11) is one of the enzymes that synthesize chondroitin sulfate (CS), which has extensive immune functions in vitro and plays a critical role in mediating the infection of host by pathogenic microorganisms.	Chondroitin Sulfates	102-104	carbohydrate sulfotransferase 11	Homo sapiens	35-41
32198024-7	2020	Confocal microscopy of quantum dot-labeled plasmid uptake in vivo reveals association between our polymers and negatively charged NG2 chondroitin sulfate proteoglycans of the SVZ extracellular matrix.	Chondroitin Sulfates	134-153	chondroitin sulfate proteoglycan 4	Mus musculus	130-133
32608461-4	2020	Preliminary results on the impact of sulfation of these disaccharides upon recombinant chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) involved in chondroitin sulfate chain initiation is also reported.	Chondroitin Sulfates	87-106	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	144-155
32599896-0	2020	Chondroitin Sulphate Proteoglycan 4 (NG2/CSPG4) Localization in Low- and High-Grade Gliomas.	Chondroitin Sulfates	0-20	proteoglycan 4	Homo sapiens	21-35
32599896-0	2020	Chondroitin Sulphate Proteoglycan 4 (NG2/CSPG4) Localization in Low- and High-Grade Gliomas.	Chondroitin Sulfates	0-20	chondroitin sulfate proteoglycan 4	Homo sapiens	37-40
32599896-0	2020	Chondroitin Sulphate Proteoglycan 4 (NG2/CSPG4) Localization in Low- and High-Grade Gliomas.	Chondroitin Sulfates	0-20	chondroitin sulfate proteoglycan 4	Homo sapiens	41-46
32599896-1	2020	BACKGROUND: Neuron glial antigen 2 or chondroitin sulphate proteoglycan 4 (NG2/CSPG4) is expressed by immature precursors/progenitor cells and is possibly involved in malignant cell transformation.	Chondroitin Sulfates	38-58	chondroitin sulfate proteoglycan 4	Homo sapiens	75-78
32599896-1	2020	BACKGROUND: Neuron glial antigen 2 or chondroitin sulphate proteoglycan 4 (NG2/CSPG4) is expressed by immature precursors/progenitor cells and is possibly involved in malignant cell transformation.	Chondroitin Sulfates	38-58	chondroitin sulfate proteoglycan 4	Homo sapiens	79-84
32607438-0	2020	Chemical Synthesis and Anti-Inflammatory Activity of Bikunin Associated Chondroitin Sulfate 24-mer.	Chondroitin Sulfates	72-91	alpha-1-microglobulin/bikunin precursor	Homo sapiens	53-60
32607438-1	2020	Bikunin, a chondroitin sulfate (CS) proteoglycan clinically used to treat acute inflammation and sepsis, contains a CS chain with more than 20 monosaccharide units.	Chondroitin Sulfates	11-30	alpha-1-microglobulin/bikunin precursor	Homo sapiens	0-7
32607438-1	2020	Bikunin, a chondroitin sulfate (CS) proteoglycan clinically used to treat acute inflammation and sepsis, contains a CS chain with more than 20 monosaccharide units.	Chondroitin Sulfates	32-34	alpha-1-microglobulin/bikunin precursor	Homo sapiens	0-7
32607438-1	2020	Bikunin, a chondroitin sulfate (CS) proteoglycan clinically used to treat acute inflammation and sepsis, contains a CS chain with more than 20 monosaccharide units.	Chondroitin Sulfates	116-118	alpha-1-microglobulin/bikunin precursor	Homo sapiens	0-7
32607438-2	2020	To understand the function of the CS chain of bikunin, synthesis of long CS chains is needed.	Chondroitin Sulfates	34-36	alpha-1-microglobulin/bikunin precursor	Homo sapiens	46-53
32607438-2	2020	To understand the function of the CS chain of bikunin, synthesis of long CS chains is needed.	Chondroitin Sulfates	73-75	alpha-1-microglobulin/bikunin precursor	Homo sapiens	46-53
32517548-7	2021	Meanwhile, the positive staining rates of CS chain modifying enzymes FAM20B, GalT-II, and EXTL2 decreased in OA and KBD groups.	Chondroitin Sulfates	42-44	FAM20B glycosaminoglycan xylosylkinase	Homo sapiens	69-75
32528626-0	2020	Skate cartilage extracts containing chondroitin sulfate ameliorates hyperlipidemia-induced inflammation and oxidative stress in high cholesterol diet-fed LDL receptor knockout mice in comparison with shark chondroitin sulfate.	Chondroitin Sulfates	36-55	low density lipoprotein receptor	Mus musculus	154-166
32528626-4	2020	Furthermore, CS or SCS significantly attenuated inflammation by reducing the serum levels of interleukin (IL)-1beta and hepatic protein expression levels of nuclear factor kappa B, inducible nitric oxide synthase, cyclooxygenase-2, and IL-1beta (P < 0.05).	Chondroitin Sulfates	13-15	interleukin 1 alpha	Mus musculus	93-115
32528626-4	2020	Furthermore, CS or SCS significantly attenuated inflammation by reducing the serum levels of interleukin (IL)-1beta and hepatic protein expression levels of nuclear factor kappa B, inducible nitric oxide synthase, cyclooxygenase-2, and IL-1beta (P < 0.05).	Chondroitin Sulfates	13-15	nitric oxide synthase 2, inducible	Mus musculus	181-212
32192320-2	2020	The aim of this study was to compare the efficacy of chondroitin sulfate (CS) course and multistrain live probiotic (LP) administered alone or in combination on the expression of TLR-2, TLR-4, TNF-alpha and NF-kappaB in articular cartilage, subchondral bone and synovial membrane during OA in rats.	Chondroitin Sulfates	53-72	toll-like receptor 2	Rattus norvegicus	179-184
32528626-4	2020	Furthermore, CS or SCS significantly attenuated inflammation by reducing the serum levels of interleukin (IL)-1beta and hepatic protein expression levels of nuclear factor kappa B, inducible nitric oxide synthase, cyclooxygenase-2, and IL-1beta (P < 0.05).	Chondroitin Sulfates	13-15	prostaglandin-endoperoxide synthase 2	Mus musculus	214-230
32528626-4	2020	Furthermore, CS or SCS significantly attenuated inflammation by reducing the serum levels of interleukin (IL)-1beta and hepatic protein expression levels of nuclear factor kappa B, inducible nitric oxide synthase, cyclooxygenase-2, and IL-1beta (P < 0.05).	Chondroitin Sulfates	13-15	interleukin 1 alpha	Mus musculus	236-244
32528626-6	2020	In addition, lipid peroxidation and nitric oxide production were attenuated in the livers of the CS and SCS groups mediated by the upregulation of hepatic proteins of antioxidant enzymes, such as superoxide dismutase, catalase, and glutathione peroxidase (P < 0.05).	Chondroitin Sulfates	97-99	catalase	Mus musculus	218-226
32265257-6	2020	In normal retina, IMPG1 and IMPG2 occupy distinct IPM compartments, represent the main source of chondroitin sulfate and are fundamental for the constitution of the cone-specific glycocalyx stained by the PNA lectin marker.	Chondroitin Sulfates	97-116	interphotoreceptor matrix proteoglycan 1	Mus musculus	18-23
32265257-6	2020	In normal retina, IMPG1 and IMPG2 occupy distinct IPM compartments, represent the main source of chondroitin sulfate and are fundamental for the constitution of the cone-specific glycocalyx stained by the PNA lectin marker.	Chondroitin Sulfates	97-116	interphotoreceptor matrix proteoglycan 2	Mus musculus	28-33
31785283-1	2020	Perineuronal nets (PNN) of the extracellular matrix are dense aggregations of chondroitin-sulfate proteoglycans that usually surround fast-spiking parvalbumin-expressing inhibitory interneurons (PV).	Chondroitin Sulfates	78-97	pinin	Serinus canaria	19-22
32192320-2	2020	The aim of this study was to compare the efficacy of chondroitin sulfate (CS) course and multistrain live probiotic (LP) administered alone or in combination on the expression of TLR-2, TLR-4, TNF-alpha and NF-kappaB in articular cartilage, subchondral bone and synovial membrane during OA in rats.	Chondroitin Sulfates	53-72	toll-like receptor 4	Rattus norvegicus	186-191
32192320-2	2020	The aim of this study was to compare the efficacy of chondroitin sulfate (CS) course and multistrain live probiotic (LP) administered alone or in combination on the expression of TLR-2, TLR-4, TNF-alpha and NF-kappaB in articular cartilage, subchondral bone and synovial membrane during OA in rats.	Chondroitin Sulfates	53-72	tumor necrosis factor	Rattus norvegicus	193-202
32192320-2	2020	The aim of this study was to compare the efficacy of chondroitin sulfate (CS) course and multistrain live probiotic (LP) administered alone or in combination on the expression of TLR-2, TLR-4, TNF-alpha and NF-kappaB in articular cartilage, subchondral bone and synovial membrane during OA in rats.	Chondroitin Sulfates	74-76	toll-like receptor 2	Rattus norvegicus	179-184
32192320-2	2020	The aim of this study was to compare the efficacy of chondroitin sulfate (CS) course and multistrain live probiotic (LP) administered alone or in combination on the expression of TLR-2, TLR-4, TNF-alpha and NF-kappaB in articular cartilage, subchondral bone and synovial membrane during OA in rats.	Chondroitin Sulfates	74-76	tumor necrosis factor	Rattus norvegicus	193-202
32331483-0	2020	A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma.	Chondroitin Sulfates	82-101	chondroitin sulfate proteoglycan 4	Homo sapiens	116-121
32144206-2	2020	It comprises two homologous "heavy chains" (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein.	Chondroitin Sulfates	80-99	CYCS pseudogene 39	Homo sapiens	44-47
32144206-2	2020	It comprises two homologous "heavy chains" (HC1 and HC2) covalently attached to chondroitin sulfate on the bikunin core protein.	Chondroitin Sulfates	80-99	CYCS pseudogene 38	Homo sapiens	52-55
31881217-10	2020	BMP4 also enhances the production of inhibitory chondroitin sulfate proteoglycans (CSPGs) in activated astrocytes in vitro and after SCI.	Chondroitin Sulfates	48-67	bone morphogenetic protein 4	Rattus norvegicus	0-4
30741846-0	2020	Primary Ovarian Tumors With Lymphogenic and Hematogenic Metastasis Express High MMP-14, Which Colocalizes With Highly Sulfated Chondroitin Sulfate in the Stroma.	Chondroitin Sulfates	127-146	matrix metallopeptidase 14	Homo sapiens	80-86
31926989-8	2020	Microglia in the AH strongly expressed NG2 chondroitin sulfate proteoglycan.	Chondroitin Sulfates	43-62	chondroitin sulfate proteoglycan 4	Rattus norvegicus	39-42
31964714-9	2020	CLEC14A physically interacted with other glycosaminoglycans, including endothelial heparan sulfate and chondroitin sulfate E, but not with neutral or sialylated oligosaccharides.	Chondroitin Sulfates	103-124	C-type lectin domain containing 14A	Homo sapiens	0-7
31664678-5	2020	The results showed that increases in the TSP-1/TGF-beta1/pSmad2/3 levels spatially and temporally matched the increases in glial fibrillary acidic protein (GFAP)/chondroitin sulfate (CS56) levels following KA administration.	Chondroitin Sulfates	162-181	thrombospondin 1	Rattus norvegicus	41-46
31664678-5	2020	The results showed that increases in the TSP-1/TGF-beta1/pSmad2/3 levels spatially and temporally matched the increases in glial fibrillary acidic protein (GFAP)/chondroitin sulfate (CS56) levels following KA administration.	Chondroitin Sulfates	162-181	transforming growth factor, beta 1	Rattus norvegicus	47-56
33464839-7	2020	In lung cancer-bearing mice using urethane as a chemical carcinogen, the inhalable LF/CS-coated PEM-RES-LCNP nanocomposites showed superior antitumor activity as revealed by a considerable decrease of the average lung weight, reduced number and diameter of cancerous lung foci, decreased expression of VEGF-1, and increased expression of active caspase-3 as well as reduced Ki-67 expression compared to the spray-dried free PEM/RES powder mixture and positive control.	Chondroitin Sulfates	86-88	caspase 3	Mus musculus	345-354
31887874-0	2020	Blood component ridable and CD44 receptor targetable nanoparticles based on a maleimide-functionalized chondroitin sulfate derivative.	Chondroitin Sulfates	103-122	CD44 molecule (Indian blood group)	Homo sapiens	28-32
31887904-1	2020	Chondroitin sulfate (CS) is a naturally derived bioactive macromolecule and the major component of extracellular matrix (ECM), which widely distributed in various organisms and has attracted much attention due to their significant bioactivities.	Chondroitin Sulfates	0-19	citrate synthase	Homo sapiens	21-23
33464839-7	2020	In lung cancer-bearing mice using urethane as a chemical carcinogen, the inhalable LF/CS-coated PEM-RES-LCNP nanocomposites showed superior antitumor activity as revealed by a considerable decrease of the average lung weight, reduced number and diameter of cancerous lung foci, decreased expression of VEGF-1, and increased expression of active caspase-3 as well as reduced Ki-67 expression compared to the spray-dried free PEM/RES powder mixture and positive control.	Chondroitin Sulfates	86-88	antigen identified by monoclonal antibody Ki 67	Mus musculus	374-379
32019907-3	2020	Using a chondroitin sulfate-specific antibody, we showed that the expression of CHSY1 was significantly associated with CS formation in glioma tissue and cells.	Chondroitin Sulfates	8-27	chondroitin sulfate synthase 1	Homo sapiens	80-85
32019907-3	2020	Using a chondroitin sulfate-specific antibody, we showed that the expression of CHSY1 was significantly associated with CS formation in glioma tissue and cells.	Chondroitin Sulfates	120-122	chondroitin sulfate synthase 1	Homo sapiens	80-85
31754016-5	2020	CHSY1 is a member of the chondroitin N-acetylgalactosaminyltransferase family that plays critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan (GAG) that is attached to the core protein to form the chondroitin sulfate proteoglycan (CSPG).	Chondroitin Sulfates	127-146	chondroitin sulfate synthase 1	Mus musculus	0-5
31555982-3	2020	Negatively-charged chondroitin sulfate in presence of gelatin guides unidirectional growth of calcium carbonate mesocrystals to form nanobullets, mediates CD44 targeting of CTCs.	Chondroitin Sulfates	19-38	CD44 molecule (Indian blood group)	Homo sapiens	155-159
31972438-1	2020	Dermatan sulfate (DS) is a glycosaminoglycan (GAG) that is produced through the epimerization of the glucuronic acid on chondroitin sulfate into iduronic acid (IduA) by dermatan sulfate epimerase (DS-epi) 1 and 2.	Chondroitin Sulfates	120-139	dermatan sulfate epimerase	Homo sapiens	169-195
31972438-1	2020	Dermatan sulfate (DS) is a glycosaminoglycan (GAG) that is produced through the epimerization of the glucuronic acid on chondroitin sulfate into iduronic acid (IduA) by dermatan sulfate epimerase (DS-epi) 1 and 2.	Chondroitin Sulfates	120-139	dermatan sulfate epimerase	Homo sapiens	197-212
31908019-3	2020	Treatment of cultured glioma cells with C4S and C6S enhanced cell viability, migration, and invasion, increased MMP-2 and MMP-9 levels, enhanced N-cadherin, but reduced E-cadherin expression.	Chondroitin Sulfates	40-43	matrix metallopeptidase 2	Homo sapiens	112-117
31908019-3	2020	Treatment of cultured glioma cells with C4S and C6S enhanced cell viability, migration, and invasion, increased MMP-2 and MMP-9 levels, enhanced N-cadherin, but reduced E-cadherin expression.	Chondroitin Sulfates	40-43	matrix metallopeptidase 9	Homo sapiens	122-127
31908019-3	2020	Treatment of cultured glioma cells with C4S and C6S enhanced cell viability, migration, and invasion, increased MMP-2 and MMP-9 levels, enhanced N-cadherin, but reduced E-cadherin expression.	Chondroitin Sulfates	40-43	cadherin 2	Homo sapiens	145-155
31908019-3	2020	Treatment of cultured glioma cells with C4S and C6S enhanced cell viability, migration, and invasion, increased MMP-2 and MMP-9 levels, enhanced N-cadherin, but reduced E-cadherin expression.	Chondroitin Sulfates	40-43	cadherin 1	Homo sapiens	169-179
31908019-3	2020	Treatment of cultured glioma cells with C4S and C6S enhanced cell viability, migration, and invasion, increased MMP-2 and MMP-9 levels, enhanced N-cadherin, but reduced E-cadherin expression.	Chondroitin Sulfates	48-51	matrix metallopeptidase 2	Homo sapiens	112-117
31908019-3	2020	Treatment of cultured glioma cells with C4S and C6S enhanced cell viability, migration, and invasion, increased MMP-2 and MMP-9 levels, enhanced N-cadherin, but reduced E-cadherin expression.	Chondroitin Sulfates	48-51	matrix metallopeptidase 9	Homo sapiens	122-127
31908019-3	2020	Treatment of cultured glioma cells with C4S and C6S enhanced cell viability, migration, and invasion, increased MMP-2 and MMP-9 levels, enhanced N-cadherin, but reduced E-cadherin expression.	Chondroitin Sulfates	48-51	cadherin 2	Homo sapiens	145-155
31908019-3	2020	Treatment of cultured glioma cells with C4S and C6S enhanced cell viability, migration, and invasion, increased MMP-2 and MMP-9 levels, enhanced N-cadherin, but reduced E-cadherin expression.	Chondroitin Sulfates	48-51	cadherin 1	Homo sapiens	169-179
31908019-5	2020	The C4S- and C6S-enhanced epithelial-to-mesenchymal transition and expression of MMP-2 occurred via activation of the PI3K/AKT signaling pathway, known to be involved in promoting cell migration and invasion.	Chondroitin Sulfates	4-7	matrix metallopeptidase 2	Homo sapiens	81-86
31908019-5	2020	The C4S- and C6S-enhanced epithelial-to-mesenchymal transition and expression of MMP-2 occurred via activation of the PI3K/AKT signaling pathway, known to be involved in promoting cell migration and invasion.	Chondroitin Sulfates	13-16	matrix metallopeptidase 2	Homo sapiens	81-86
31486703-11	2020	IL-1beta-induced COX-2 gene expression and PGE2 production were significantly reduced by the combination of (ASU+GLU+CS).	Chondroitin Sulfates	117-119	cox2	Glycine max	17-22
31867955-2	2020	We present a cell membrane targeting complex based on chondroitin sulfate (CS)-conjugated superparamagnetic iron oxide nanoparticles (CS-SPIONs).	Chondroitin Sulfates	54-73	citrate synthase	Rattus norvegicus	75-77
31867955-2	2020	We present a cell membrane targeting complex based on chondroitin sulfate (CS)-conjugated superparamagnetic iron oxide nanoparticles (CS-SPIONs).	Chondroitin Sulfates	54-73	citrate synthase	Rattus norvegicus	134-136
32182995-0	2020	Chondroitin Sulfate Promotes the Proliferation of Keloid Fibroblasts Through Activation of the Integrin and Protein Kinase B Pathways.	Chondroitin Sulfates	0-19	protein tyrosine kinase 2 beta	Homo sapiens	108-124
32182995-11	2020	We revealed that CS probably activates the AKT pathway through integrin to induce KF proliferation.	Chondroitin Sulfates	17-19	AKT serine/threonine kinase 1	Homo sapiens	43-46
31486703-0	2020	Avocado/Soybean Unsaponifiables, Glucosamine and Chondroitin Sulfate Combination Inhibits Proinflammatory COX-2 Expression and Prostaglandin E2 Production in Tendon-Derived Cells.	Chondroitin Sulfates	49-68	cox2	Glycine max	106-111
31590861-2	2020	In this context, this study evaluated the effect of lecithin on the characteristics of chitosan (CHI) and chondroitin sulfate (CS) nanoparticles, when applied in curcumin (Curc) release.	Chondroitin Sulfates	106-125	citrate synthase	Homo sapiens	127-129
31773303-6	2020	The increase in CS content in GBM tumours was accompanied by upregulation of decorin (1.5-fold), biglycan (3-fold) and serglycin (2-fold) expression (p &lt; 0.05), while only decorin expression level was negatively associated with the overall survival rate of the GBM patients (p &lt; 0.05).	Chondroitin Sulfates	16-18	biglycan	Homo sapiens	97-105
31359422-0	2020	Thermodynamic profiles of the interactions of suramin, chondroitin sulfate, and pentosan polysulfate with the inhibitory domain of TIMP-3.	Chondroitin Sulfates	55-74	TIMP metallopeptidase inhibitor 3	Homo sapiens	131-137
31359422-4	2020	Here, we report the thermodynamics of the interactions of the sGAG-binding N-domain of TIMP-3 with chondroitin sulfate, pentosan polysulfate, and suramin in solution using isothermal titration calorimetry.	Chondroitin Sulfates	99-118	TIMP metallopeptidase inhibitor 3	Homo sapiens	87-93
31754016-5	2020	CHSY1 is a member of the chondroitin N-acetylgalactosaminyltransferase family that plays critical roles in the biosynthesis of chondroitin sulfate, a glycosaminoglycan (GAG) that is attached to the core protein to form the chondroitin sulfate proteoglycan (CSPG).	Chondroitin Sulfates	223-242	chondroitin sulfate synthase 1	Mus musculus	0-5
31754016-6	2020	Consistent with this function, the Chsy1 mutation dramatically decreases chondroitin sulfate GAGs in the retina and hippocampus.	Chondroitin Sulfates	73-92	chondroitin sulfate synthase 1	Mus musculus	35-40
31754016-9	2020	Specifically, chondroitin sulfate (CS) modification of proteins by CHSY1 appears critical for proper regulation of immune cells of the myeloid lineage and for maintaining the integrity of neuronal tissues, since a defect in this gene results in increased inflammation and abnormal phenotypes associated with age-related diseases.	Chondroitin Sulfates	14-33	chondroitin sulfate synthase 1	Mus musculus	67-72
31754016-9	2020	Specifically, chondroitin sulfate (CS) modification of proteins by CHSY1 appears critical for proper regulation of immune cells of the myeloid lineage and for maintaining the integrity of neuronal tissues, since a defect in this gene results in increased inflammation and abnormal phenotypes associated with age-related diseases.	Chondroitin Sulfates	35-37	chondroitin sulfate synthase 1	Mus musculus	67-72
31484722-4	2019	Inflammation promotes the transfer of HCs from chondroitin 4-sulfate to hyaluronan by tumor necrosis factor stimulated gene 6 protein (TSG-6).	Chondroitin Sulfates	47-68	TNF alpha induced protein 6	Homo sapiens	86-133
31905796-5	2019	Pathogenic variants in CHST14 or DSE lead to reduced activities of relevant enzymes, resulting in a negligible amount of dermatan sulfate (DS) and an excessive amount of chondroitin sulfate.	Chondroitin Sulfates	170-189	carbohydrate sulfotransferase 14	Homo sapiens	23-29
31905796-5	2019	Pathogenic variants in CHST14 or DSE lead to reduced activities of relevant enzymes, resulting in a negligible amount of dermatan sulfate (DS) and an excessive amount of chondroitin sulfate.	Chondroitin Sulfates	170-189	dermatan sulfate epimerase	Homo sapiens	33-36
31949431-7	2019	Finally, we reported here a decrease in the content of cell-surface syndecan-1 and an increase in the levels of chondroitin sulfate proteoglycans such as versican in Gal-3 knockdown 4T1 cells both in vitro and in vivo.	Chondroitin Sulfates	112-131	lectin, galactose binding, soluble 3	Mus musculus	166-171
31670365-8	2019	Furthermore, selectivity studies performed directly on microarrays with chondroitin sulfate A (CS-A) demonstrated the value of screening for both affinity and selectivity in the development of CBPs.	Chondroitin Sulfates	72-93	chorionic somatomammotropin hormone 1	Homo sapiens	95-99
33395959-8	2020	MTR correlated positively with neuron density in CA3 and with chondroitin sulfate in CA3 and CA1.	Chondroitin Sulfates	62-81	carbonic anhydrase 3	Homo sapiens	85-88
31532704-2	2020	Versican (VCAN), a chondroitin sulphate proteoglycan promotes progression in solid tumours but there is dearth of literature in MM.	Chondroitin Sulfates	19-39	versican	Homo sapiens	0-8
31532704-2	2020	Versican (VCAN), a chondroitin sulphate proteoglycan promotes progression in solid tumours but there is dearth of literature in MM.	Chondroitin Sulfates	19-39	versican	Homo sapiens	10-14
31377624-1	2019	Self-assembled nanoparticles using the biopolymers chitosan (CH) and chondroitin sulfate (CS) were developed to improve the biological activity of anthocyanin (ACN).	Chondroitin Sulfates	69-88	DDB1 and CUL4 associated factor 7	Homo sapiens	147-158
31377624-1	2019	Self-assembled nanoparticles using the biopolymers chitosan (CH) and chondroitin sulfate (CS) were developed to improve the biological activity of anthocyanin (ACN).	Chondroitin Sulfates	90-92	DDB1 and CUL4 associated factor 7	Homo sapiens	147-158
31750849-4	2019	We found that CS-modified PET grafts significantly regulated the macrophage phenotype switching from M1 to M2 and promoted the expression of pro-repair cytokines including interleukin (IL)-4, IL-10 and transforming growth factor (TGF)-beta1.	Chondroitin Sulfates	14-16	interleukin 4	Homo sapiens	172-190
31750849-4	2019	We found that CS-modified PET grafts significantly regulated the macrophage phenotype switching from M1 to M2 and promoted the expression of pro-repair cytokines including interleukin (IL)-4, IL-10 and transforming growth factor (TGF)-beta1.	Chondroitin Sulfates	14-16	interleukin 10	Homo sapiens	192-197
31750849-4	2019	We found that CS-modified PET grafts significantly regulated the macrophage phenotype switching from M1 to M2 and promoted the expression of pro-repair cytokines including interleukin (IL)-4, IL-10 and transforming growth factor (TGF)-beta1.	Chondroitin Sulfates	14-16	transforming growth factor beta 1	Homo sapiens	202-240
33405700-4	2019	Loading of type I collagen (COL) and surface modification with fibronectin and gelatin using layer-by-layer assembly techniques improved the adhesion and spreading of fibroblast cells to/on the surface of CS/CHI hollow fibers.	Chondroitin Sulfates	205-207	fibronectin 1	Homo sapiens	63-74
31423530-10	2019	The functional classification of SLC35D1 as a general nucleotide sugar transporter of the endoplasmic reticulum (ER) suggests an expanded role for this transporter beyond chondroitin sulfate biosynthesis to a variety of important glycosylation reactions occurring in the endoplasmic reticulum.	Chondroitin Sulfates	171-190	solute carrier family 35 member D1	Homo sapiens	33-40
30963568-4	2019	CHST15 catalyzes sulfation of the C6 hydroxyl group of the N-acetyl galactosamine 4-sulfate moiety in chondroitin sulfate to form the 4,6-disulfated chondroitin sulfate variant known as the CS-E isoform.	Chondroitin Sulfates	102-121	carbohydrate sulfotransferase 15	Homo sapiens	0-6
30963568-4	2019	CHST15 catalyzes sulfation of the C6 hydroxyl group of the N-acetyl galactosamine 4-sulfate moiety in chondroitin sulfate to form the 4,6-disulfated chondroitin sulfate variant known as the CS-E isoform.	Chondroitin Sulfates	102-121	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	190-194
30963568-4	2019	CHST15 catalyzes sulfation of the C6 hydroxyl group of the N-acetyl galactosamine 4-sulfate moiety in chondroitin sulfate to form the 4,6-disulfated chondroitin sulfate variant known as the CS-E isoform.	Chondroitin Sulfates	149-168	carbohydrate sulfotransferase 15	Homo sapiens	0-6
30963568-4	2019	CHST15 catalyzes sulfation of the C6 hydroxyl group of the N-acetyl galactosamine 4-sulfate moiety in chondroitin sulfate to form the 4,6-disulfated chondroitin sulfate variant known as the CS-E isoform.	Chondroitin Sulfates	149-168	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	190-194
30963568-8	2019	In corroboration with this mechanism, blocking cell surface chondroitin sulfate using a pan-CS antibody or an antibody specifically recognizes the CS-E isoform significantly suppressed HOTAIR-induced invasion.	Chondroitin Sulfates	60-79	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	147-151
30963568-8	2019	In corroboration with this mechanism, blocking cell surface chondroitin sulfate using a pan-CS antibody or an antibody specifically recognizes the CS-E isoform significantly suppressed HOTAIR-induced invasion.	Chondroitin Sulfates	60-79	HOX transcript antisense RNA	Homo sapiens	185-191
31683965-7	2019	The DGL/CSA-PNPs induced the apoptosis of JEG3 cells through caspase-3 and the P53 signaling pathway.	Chondroitin Sulfates	8-11	caspase 3	Homo sapiens	61-70
31702028-5	2019	Neurites treated with PTEN inhibitor exhibited significant enhancements in elongation, initiation and crossing abilities when they encountered chondroitin sulfate proteoglycans in vitro.	Chondroitin Sulfates	143-162	phosphatase and tensin homolog	Homo sapiens	22-26
31702028-8	2019	The present study demonstrated that PTEN inhibition can promote axonal elongation and initiation in cerebral cortical neurons, as well as the ability to cross the chondroitin sulfate proteoglycan border.	Chondroitin Sulfates	163-182	phosphatase and tensin homolog	Homo sapiens	36-40
31612015-10	2019	Low CEACAM7 expression may be associated with the activation of glycosaminoglycan biosynthesis-chondroitin sulfate and extracellular matrix receptor interaction pathways and may affect the prognosis of CRC.	Chondroitin Sulfates	95-114	CEA cell adhesion molecule 7	Homo sapiens	4-11
31676809-0	2019	Degrading products of chondroitin sulfate can induce hypertrophy-like changes and MMP-13/ADAMTS5 production in chondrocytes.	Chondroitin Sulfates	22-41	matrix metallopeptidase 13	Homo sapiens	82-88
31676809-0	2019	Degrading products of chondroitin sulfate can induce hypertrophy-like changes and MMP-13/ADAMTS5 production in chondrocytes.	Chondroitin Sulfates	22-41	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	89-96
31306703-1	2019	The purpose of this work is to stabilize zein nanoparticles with anionic polysaccharides-chondroitin sulfate (CS) to overcome the poor colloidal stability of zein nanoparticles.	Chondroitin Sulfates	89-108	citrate synthase	Homo sapiens	110-112
31594821-0	2019	Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA.	Chondroitin Sulfates	160-163	cripto, FRL-1, cryptic family 1	Homo sapiens	14-21
31484722-4	2019	Inflammation promotes the transfer of HCs from chondroitin 4-sulfate to hyaluronan by tumor necrosis factor stimulated gene 6 protein (TSG-6).	Chondroitin Sulfates	47-68	TNF alpha induced protein 6	Homo sapiens	135-140
30938133-0	2019	The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis.	Chondroitin Sulfates	36-55	collagen type II alpha 1 chain	Rattus norvegicus	91-97
31398353-11	2019	The wide range of conditions where the benefits of chondroitinase treatment have been demonstrated reflects the complex roles that chondroitin sulphate proteoglycans (its substrate) play in health and disease and warrants the enzyme"s further development as a therapy.	Chondroitin Sulfates	131-151	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	51-65
31325655-3	2019	Exome sequencing revealed a biallelic loss of function mutation in CSGALNACT1, which encodes chondroitin sulfate N-acetylgalactosaminyltransferase 1 and plays a major role in the chondroitin sulfate chain biosynthesis and therefore in the synthesis of glycosaminoglycans.	Chondroitin Sulfates	93-112	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	67-77
30938133-2	2019	The aim of this study, was to describe the effect of a multistrain probiotic (PB) and chondroitin sulfate (CS), administered separately or in combination, on the expression of Ptgs2, Tgfb1 and Col2a1 during monoiodoacetate-induced OA in male rats.	Chondroitin Sulfates	86-105	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	176-181
30938133-2	2019	The aim of this study, was to describe the effect of a multistrain probiotic (PB) and chondroitin sulfate (CS), administered separately or in combination, on the expression of Ptgs2, Tgfb1 and Col2a1 during monoiodoacetate-induced OA in male rats.	Chondroitin Sulfates	86-105	transforming growth factor, beta 1	Rattus norvegicus	183-188
30938133-2	2019	The aim of this study, was to describe the effect of a multistrain probiotic (PB) and chondroitin sulfate (CS), administered separately or in combination, on the expression of Ptgs2, Tgfb1 and Col2a1 during monoiodoacetate-induced OA in male rats.	Chondroitin Sulfates	86-105	collagen type II alpha 1 chain	Rattus norvegicus	193-199
30938133-2	2019	The aim of this study, was to describe the effect of a multistrain probiotic (PB) and chondroitin sulfate (CS), administered separately or in combination, on the expression of Ptgs2, Tgfb1 and Col2a1 during monoiodoacetate-induced OA in male rats.	Chondroitin Sulfates	107-109	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	176-181
30938133-2	2019	The aim of this study, was to describe the effect of a multistrain probiotic (PB) and chondroitin sulfate (CS), administered separately or in combination, on the expression of Ptgs2, Tgfb1 and Col2a1 during monoiodoacetate-induced OA in male rats.	Chondroitin Sulfates	107-109	transforming growth factor, beta 1	Rattus norvegicus	183-188
30938133-2	2019	The aim of this study, was to describe the effect of a multistrain probiotic (PB) and chondroitin sulfate (CS), administered separately or in combination, on the expression of Ptgs2, Tgfb1 and Col2a1 during monoiodoacetate-induced OA in male rats.	Chondroitin Sulfates	107-109	collagen type II alpha 1 chain	Rattus norvegicus	193-199
30938133-8	2019	Separate administration of PB and CS reduced Ptgs2 and Tgfb1 expressions.	Chondroitin Sulfates	34-36	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	45-50
30938133-8	2019	Separate administration of PB and CS reduced Ptgs2 and Tgfb1 expressions.	Chondroitin Sulfates	34-36	transforming growth factor, beta 1	Rattus norvegicus	55-60
31002379-3	2019	Then, high-dose LL37 (10 mumol L-1 ) was bound to varying concentrations of three GAGs, heparin, chondroitin sulphate and hyaluronic acid, and their cytotoxic effects on hDPCs and antimicrobial effects were evaluated and compared.	Chondroitin Sulfates	97-117	cathelicidin antimicrobial peptide	Homo sapiens	16-20
31181256-1	2019	BACKGROUND: Chondroitin sulfate (CS) chains are prominent extra/pericellular matrix components in the central nervous system (CNS) and can exert positive or negative regulatory effects on neurite outgrowth, depending on the CS structure and the amount.	Chondroitin Sulfates	12-31	citrate synthase	Homo sapiens	33-35
31181256-1	2019	BACKGROUND: Chondroitin sulfate (CS) chains are prominent extra/pericellular matrix components in the central nervous system (CNS) and can exert positive or negative regulatory effects on neurite outgrowth, depending on the CS structure and the amount.	Chondroitin Sulfates	12-31	citrate synthase	Homo sapiens	224-226
31002379-9	2019	LL37 (10 mumol L-1 ) binding to chondroitin sulphate exhibited similar functions (P &lt; 0.01); however, the effective chondroitin sulphate concentration was highly restricted (3 mug mL-1 ).	Chondroitin Sulfates	32-52	cathelicidin antimicrobial peptide	Homo sapiens	0-4
31002379-9	2019	LL37 (10 mumol L-1 ) binding to chondroitin sulphate exhibited similar functions (P &lt; 0.01); however, the effective chondroitin sulphate concentration was highly restricted (3 mug mL-1 ).	Chondroitin Sulfates	119-139	cathelicidin antimicrobial peptide	Homo sapiens	0-4
31002379-9	2019	LL37 (10 mumol L-1 ) binding to chondroitin sulphate exhibited similar functions (P &lt; 0.01); however, the effective chondroitin sulphate concentration was highly restricted (3 mug mL-1 ).	Chondroitin Sulfates	119-139	L1 cell adhesion molecule	Mus musculus	183-187
31470599-2	2019	Chondroitin sulfate (CS) is recommended as first-line therapy.	Chondroitin Sulfates	0-19	citrate synthase	Homo sapiens	21-23
31207331-0	2019	Chondroitin sulfate immobilized PCL nanofibers enhance chondrogenic differentiation of mesenchymal stem cells.	Chondroitin Sulfates	0-19	PHD finger protein 1	Homo sapiens	32-35
31207331-1	2019	Cold Atmospheric Plasma (CAP) is used as a promising method in surface modification for immobilization of chondroitin sulfate functional biomacromolecules on PCL nanofibrous substrates for cartilage tissue engineering.	Chondroitin Sulfates	106-125	PHD finger protein 1	Homo sapiens	158-161
31443385-3	2019	The MNPs were prepared by co-precipitation, and after careful purification, they were coated by chondroitin-sulfate-A (CSA).	Chondroitin Sulfates	119-122	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	96-117
31221324-1	2019	We use small angle neutron scattering (SANS) to characterize the internal morphology of nanoparticles (NPs) formed by the complexation between chondroitin sulfate (CS) and bovine serum albumin (BSA) and subsequent stabilization by thermal treatment.	Chondroitin Sulfates	164-166	albumin	Homo sapiens	179-198
31061498-5	2019	CS activates PTPRsigma, which dephosphorylates cortactin-herein identified as a new PTPRsigma substrate-and disrupts autophagy flux at the autophagosome-lysosome fusion step.	Chondroitin Sulfates	0-2	cortactin	Homo sapiens	47-56
31175155-4	2019	In this study, using several approaches, including epitope-specific antibodies, immunohistochemistry, and EM analyses, we demonstrate that human HMC-1 mast cells produce the CS-degrading enzymes hyaluronidase-1 (HYAL1) and HYAL4.	Chondroitin Sulfates	174-176	hyaluronidase 1	Homo sapiens	195-210
31175155-4	2019	In this study, using several approaches, including epitope-specific antibodies, immunohistochemistry, and EM analyses, we demonstrate that human HMC-1 mast cells produce the CS-degrading enzymes hyaluronidase-1 (HYAL1) and HYAL4.	Chondroitin Sulfates	174-176	hyaluronidase 1	Homo sapiens	212-217
31175155-4	2019	In this study, using several approaches, including epitope-specific antibodies, immunohistochemistry, and EM analyses, we demonstrate that human HMC-1 mast cells produce the CS-degrading enzymes hyaluronidase-1 (HYAL1) and HYAL4.	Chondroitin Sulfates	174-176	hyaluronidase 4	Homo sapiens	223-228
31175155-5	2019	We observed that treating the two model CS proteoglycans aggrecan and serglycin with HYAL1 and HYAL4 in vitro cleaves the CS chains into lower molecular weight forms with nonreducing end oligosaccharide structures similar to CS stub neoepitopes generated after digestion with the bacterial lyase chondroitinase ABC.	Chondroitin Sulfates	40-42	hyaluronidase 1	Homo sapiens	85-90
31175155-5	2019	We observed that treating the two model CS proteoglycans aggrecan and serglycin with HYAL1 and HYAL4 in vitro cleaves the CS chains into lower molecular weight forms with nonreducing end oligosaccharide structures similar to CS stub neoepitopes generated after digestion with the bacterial lyase chondroitinase ABC.	Chondroitin Sulfates	40-42	hyaluronidase 4	Homo sapiens	95-100
31175155-5	2019	We observed that treating the two model CS proteoglycans aggrecan and serglycin with HYAL1 and HYAL4 in vitro cleaves the CS chains into lower molecular weight forms with nonreducing end oligosaccharide structures similar to CS stub neoepitopes generated after digestion with the bacterial lyase chondroitinase ABC.	Chondroitin Sulfates	122-124	hyaluronidase 1	Homo sapiens	85-90
31175155-5	2019	We observed that treating the two model CS proteoglycans aggrecan and serglycin with HYAL1 and HYAL4 in vitro cleaves the CS chains into lower molecular weight forms with nonreducing end oligosaccharide structures similar to CS stub neoepitopes generated after digestion with the bacterial lyase chondroitinase ABC.	Chondroitin Sulfates	122-124	hyaluronidase 4	Homo sapiens	95-100
31175155-7	2019	Furthermore, we noted that HYAL4 cleaves CS chains into lower molecular weight forms that range in length from tetra- to dodecasaccharides.	Chondroitin Sulfates	41-43	hyaluronidase 4	Homo sapiens	27-32
31175155-8	2019	These results provide first evidence that mast cells produce HYAL4 and that this enzyme may play a specific role in maintaining alpha-granule homeostasis in these cells by cleaving CS glycosaminoglycan chains attached to serglycin.	Chondroitin Sulfates	181-183	hyaluronidase 4	Homo sapiens	61-66
30919596-2	2019	Women are more susceptible to malaria during pregnancy due to malaria-induced inflammation and the sequestration of infected red blood cells in the placenta, which bind to the chondroitin sulfate portion of syndecan-1 on the syncytiotrophoblast and in the intervillous space.	Chondroitin Sulfates	176-195	syndecan 1	Homo sapiens	207-217
30919596-9	2019	Inflammation also upregulates MMP-9 and the removal of heparan sulfate gives MMP-9 access to cleave syndecan-1, thereby releasing dimeric syndecan-1 ectodomains with at least four chondroitin sulfate chains attached.	Chondroitin Sulfates	180-199	syndecan 1	Homo sapiens	138-148
31578248-6	2019	Competitive enzyme-linked immunosorbent assays (ELISAs) showed that D16 blocks interactions between TcdB and its receptor, chondroitin sulfate proteoglycan 4 (CSPG4).	Chondroitin Sulfates	123-142	chondroitin sulfate proteoglycan 4	Homo sapiens	159-164
31375727-4	2019	The first disk with C6S was targeted to remove chylomicrons, very-low-density lipoprotein (VLDL) particles, and their remnants including intermediate-density lipoprotein (IDL) particles, thus allowing the remaining major lipoprotein species, i.e. LDL, lipoprotein(a) (Lp(a)), and high-density lipoprotein (HDL) to flow to the anti-apoB-100 disk.	Chondroitin Sulfates	20-23	lipoprotein(a)	Homo sapiens	252-266
31375727-4	2019	The first disk with C6S was targeted to remove chylomicrons, very-low-density lipoprotein (VLDL) particles, and their remnants including intermediate-density lipoprotein (IDL) particles, thus allowing the remaining major lipoprotein species, i.e. LDL, lipoprotein(a) (Lp(a)), and high-density lipoprotein (HDL) to flow to the anti-apoB-100 disk.	Chondroitin Sulfates	20-23	lipoprotein(a)	Homo sapiens	268-273
31375727-4	2019	The first disk with C6S was targeted to remove chylomicrons, very-low-density lipoprotein (VLDL) particles, and their remnants including intermediate-density lipoprotein (IDL) particles, thus allowing the remaining major lipoprotein species, i.e. LDL, lipoprotein(a) (Lp(a)), and high-density lipoprotein (HDL) to flow to the anti-apoB-100 disk.	Chondroitin Sulfates	20-23	apolipoprotein B	Homo sapiens	331-339
30959056-1	2019	Mucopolysaccharidosis IVA (MPS IVA or Morquio A syndrome) is a lysosomal storage disease caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), leading to lysosomal storage of keratan sulfate and chondroitin-6-sulfate.	Chondroitin Sulfates	220-241	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	160-165
30988054-1	2019	During pregnancy, Plasmodium falciparum-infected erythrocytes (IE) accumulate in the intervillous spaces of the placenta by binding to chondroitin sulfate A (CSA) and elicit inflammatory responses that are associated with poor pregnancy outcomes.	Chondroitin Sulfates	135-156	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	158-161
30879657-0	2019	Preparation, characterisation and in vitro and in vivo evaluation of CD44-targeted chondroitin sulphate-conjugated doxorubicin PLGA nanoparticles.	Chondroitin Sulfates	83-103	CD44 molecule (Indian blood group)	Homo sapiens	69-73
30879657-2	2019	The chondroitin sulphate-doxorubicin conjugate and its poly(lactic-co-glycolic acid) (PLGA) nanoparticles (CS-Dox-PLGA) were successfully synthesised, and then characterized by Fourier-transform infrared spectroscopy (FTIR), proton magnetic resonance (1HNMR), thermogravimetric analysis/differential scanning calorimetry (TGA/DSC), transmission electron microscope (TEM), zeta potential and laser light scattering.	Chondroitin Sulfates	4-24	desmocollin 3	Homo sapiens	326-329
30861432-12	2019	However, TM EGF-like domain 5 was required and TM chondroitin sulfate (CS) proteoglycan sites serine 490 and serine 492 assisted in PAR2 cleavage, while thrombin preferentially cleaved at arginine 36 on PAR2"s N-terminus.	Chondroitin Sulfates	50-69	thrombomodulin	Homo sapiens	47-49
30644653-7	2019	We found that combining MSC-S and HA/CS increased the expression of CD44 receptors colocalized with HA, suggesting that the observed therapeutic effects between the MSC-S and HA/CS are in part mediated by CD44 receptor upregulation and activation by HA.	Chondroitin Sulfates	37-39	CD44 molecule (Indian blood group)	Homo sapiens	68-72
30861432-12	2019	However, TM EGF-like domain 5 was required and TM chondroitin sulfate (CS) proteoglycan sites serine 490 and serine 492 assisted in PAR2 cleavage, while thrombin preferentially cleaved at arginine 36 on PAR2"s N-terminus.	Chondroitin Sulfates	50-69	F2R like trypsin receptor 1	Homo sapiens	132-136
30644653-7	2019	We found that combining MSC-S and HA/CS increased the expression of CD44 receptors colocalized with HA, suggesting that the observed therapeutic effects between the MSC-S and HA/CS are in part mediated by CD44 receptor upregulation and activation by HA.	Chondroitin Sulfates	37-39	CD44 molecule (Indian blood group)	Homo sapiens	205-209
30644653-7	2019	We found that combining MSC-S and HA/CS increased the expression of CD44 receptors colocalized with HA, suggesting that the observed therapeutic effects between the MSC-S and HA/CS are in part mediated by CD44 receptor upregulation and activation by HA.	Chondroitin Sulfates	178-180	CD44 molecule (Indian blood group)	Homo sapiens	68-72
30644653-7	2019	We found that combining MSC-S and HA/CS increased the expression of CD44 receptors colocalized with HA, suggesting that the observed therapeutic effects between the MSC-S and HA/CS are in part mediated by CD44 receptor upregulation and activation by HA.	Chondroitin Sulfates	178-180	CD44 molecule (Indian blood group)	Homo sapiens	205-209
30861432-12	2019	However, TM EGF-like domain 5 was required and TM chondroitin sulfate (CS) proteoglycan sites serine 490 and serine 492 assisted in PAR2 cleavage, while thrombin preferentially cleaved at arginine 36 on PAR2"s N-terminus.	Chondroitin Sulfates	71-73	thrombomodulin	Homo sapiens	47-49
30861432-12	2019	However, TM EGF-like domain 5 was required and TM chondroitin sulfate (CS) proteoglycan sites serine 490 and serine 492 assisted in PAR2 cleavage, while thrombin preferentially cleaved at arginine 36 on PAR2"s N-terminus.	Chondroitin Sulfates	71-73	F2R like trypsin receptor 1	Homo sapiens	132-136
32255121-4	2019	The primary amines are used to form covalent crosslinks with chondroitin sulfate, an important component of cartilage that promotes regeneration, to form a hydrogel (EDAG-CS).	Chondroitin Sulfates	61-80	hemogen	Homo sapiens	166-170
30949044-1	2019	Hyaluronan and proteoglycan link protein 2 (Hapln2) is important for the binding of chondroitin sulfate proteoglycans to hyaluronan.	Chondroitin Sulfates	84-103	hyaluronan and proteoglycan link protein 2	Homo sapiens	44-50
33405854-3	2019	In this work, chondroitin sulfate (CS), as an important component of the extracellular matrix network, was introduced into CPC to enhance its osteogenesis ability.	Chondroitin Sulfates	14-33	citrate synthase	Homo sapiens	35-37
30635946-11	2019	The upregulation of chondroitin sulfate proteoglycan, sometimes bearing chondroitin sulfate of type E sugar moieties, binding APRIL, in reactive astrocytes explained the latter selectivity.	Chondroitin Sulfates	20-39	TNF superfamily member 13	Homo sapiens	126-131
30698412-2	2019	Previously, we established that ZIKV-EP (envelope protein) binds to human placental chondroitin sulfate (CS), suggesting that CS may be a potential host cell surface receptor in ZIKV pathogenesis.	Chondroitin Sulfates	84-103	citrate synthase	Homo sapiens	105-107
30698412-2	2019	Previously, we established that ZIKV-EP (envelope protein) binds to human placental chondroitin sulfate (CS), suggesting that CS may be a potential host cell surface receptor in ZIKV pathogenesis.	Chondroitin Sulfates	84-103	citrate synthase	Homo sapiens	126-128
32254916-3	2019	Chondroitin sulfate (CS), a sulfated glycosaminoglycan (GAG), is distributed throughout animal bodies, including cartilage and the extracellular matrix (ECM), and it has been widely utilized in the dietary supplement and pharmaceutical industries.	Chondroitin Sulfates	0-19	citrate synthase	Homo sapiens	21-23
29658360-10	2019	MMP13 mRNA was downregulated following CS stimulation of both inner and outer meniscus cells.	Chondroitin Sulfates	39-41	matrix metallopeptidase 13	Homo sapiens	0-5
29863957-2	2019	The current study aimed to develop a localized controlled delivery system from RSV by incorporating RSV-loaded chitosan/chondroitin sulfate (CTS/CS) nanoparticles into thermosensitive Pluronic F127/hyaluronic acid (PF127/HA) hydrogel.	Chondroitin Sulfates	120-139	transthyretin	Homo sapiens	141-147
30865416-1	2019	Pretibial myxedema or thyroid dermopathy constitutes dermal deposition of mucin, primarily hyaluronic acid and chondroitin sulfate.	Chondroitin Sulfates	111-130	LOC100508689	Homo sapiens	74-79
30648841-7	2019	CS dissociated from the outer shell and sensitized cancer cells to the antitumor drugs through downregulation of Bcl-XL, an antiapoptosis protein.	Chondroitin Sulfates	0-2	BCL2 like 1	Homo sapiens	113-119
30853887-4	2019	It has been reported that dermatan 4-O-sulfotransferase-1 (Chst14/D4st1) specific for DS, but not chondroitin 4-O-sulfotransferase-1 (Chst11/C4st1) specific for CS, regulates proliferation and neurogenesis of neural stem cells (NSCs), indicating that CS and DS play distinct roles in the self-renewal and differentiation of NSCs.	Chondroitin Sulfates	161-163	carbohydrate sulfotransferase 14	Mus musculus	59-65
30853887-4	2019	It has been reported that dermatan 4-O-sulfotransferase-1 (Chst14/D4st1) specific for DS, but not chondroitin 4-O-sulfotransferase-1 (Chst11/C4st1) specific for CS, regulates proliferation and neurogenesis of neural stem cells (NSCs), indicating that CS and DS play distinct roles in the self-renewal and differentiation of NSCs.	Chondroitin Sulfates	251-253	carbohydrate sulfotransferase 14	Mus musculus	59-65
30906633-2	2019	Here we report that DSE, the enzyme that catalyzes the conversion of chondroitin sulfate (CS) to dermatan sulfate (DS), is a critical mediator of malignant character in HCC, through regulation of CCL5 signaling.	Chondroitin Sulfates	69-88	dermatan sulfate epimerase	Mus musculus	20-23
30906633-2	2019	Here we report that DSE, the enzyme that catalyzes the conversion of chondroitin sulfate (CS) to dermatan sulfate (DS), is a critical mediator of malignant character in HCC, through regulation of CCL5 signaling.	Chondroitin Sulfates	69-88	chemokine (C-C motif) ligand 5	Mus musculus	196-200
30906633-2	2019	Here we report that DSE, the enzyme that catalyzes the conversion of chondroitin sulfate (CS) to dermatan sulfate (DS), is a critical mediator of malignant character in HCC, through regulation of CCL5 signaling.	Chondroitin Sulfates	90-92	dermatan sulfate epimerase	Mus musculus	20-23
30906633-2	2019	Here we report that DSE, the enzyme that catalyzes the conversion of chondroitin sulfate (CS) to dermatan sulfate (DS), is a critical mediator of malignant character in HCC, through regulation of CCL5 signaling.	Chondroitin Sulfates	90-92	chemokine (C-C motif) ligand 5	Mus musculus	196-200
30299593-4	2019	In Pacinian corpuscles chondroitin sulfate was found associated to a CD34 positive endoneurial-related layer, interposed between the S100 protein positive inner core cells, and the vimentin positive inner core and outer core-capsule cells.	Chondroitin Sulfates	23-42	CD34 molecule	Homo sapiens	69-73
30299593-4	2019	In Pacinian corpuscles chondroitin sulfate was found associated to a CD34 positive endoneurial-related layer, interposed between the S100 protein positive inner core cells, and the vimentin positive inner core and outer core-capsule cells.	Chondroitin Sulfates	23-42	S100 calcium binding protein A1	Homo sapiens	133-137
30339470-7	2019	From these and previous observations, we drew the conclusion that different CS and DS expression patterns can be growth permitting, growth inhibiting, or neutral for regrowing or sprouting axons, depending on the tissue environment of a particular animal species.-Sahu, S., Li, R., Loers, G., Schachner, M. Knockdown of chondroitin-4-sulfotransferase-1, but not of dermatan-4-sulfotransferase-1, accelerates regeneration of zebrafish after spinal cord injury.	Chondroitin Sulfates	76-78	carbohydrate (chondroitin 4) sulfotransferase 11	Danio rerio	320-352
30339470-7	2019	From these and previous observations, we drew the conclusion that different CS and DS expression patterns can be growth permitting, growth inhibiting, or neutral for regrowing or sprouting axons, depending on the tissue environment of a particular animal species.-Sahu, S., Li, R., Loers, G., Schachner, M. Knockdown of chondroitin-4-sulfotransferase-1, but not of dermatan-4-sulfotransferase-1, accelerates regeneration of zebrafish after spinal cord injury.	Chondroitin Sulfates	76-78	carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14	Danio rerio	365-394
30688376-0	2019	Chondroitin sulfate proteoglycan represses neural stem/progenitor cells migration via PTPsigma/alpha-actinin4 signaling pathway.	Chondroitin Sulfates	0-19	protein tyrosine phosphatase receptor type S	Homo sapiens	86-94
30688376-0	2019	Chondroitin sulfate proteoglycan represses neural stem/progenitor cells migration via PTPsigma/alpha-actinin4 signaling pathway.	Chondroitin Sulfates	0-19	actinin alpha 4	Homo sapiens	95-109
30678366-7	2019	The 58 kDa SPI contained alpha1-microglobulin, bikunin and chondroitin-4-sulfate stub epitope consistent with an identity of alpha1-microglobulin-bikunin (AMBP) precursor and was also isolated by concanavalin-A lectin affinity chromatography indicating it had N-glycosylation.	Chondroitin Sulfates	59-80	chromogranin A	Homo sapiens	11-14
33405862-4	2019	Cross-linking of the decellularized cornea with oxidized chondroitin sulfate was validated by ATR-FTIR analysis.	Chondroitin Sulfates	57-76	ATR serine/threonine kinase	Homo sapiens	94-97
30521103-0	2019	Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33.	Chondroitin Sulfates	0-19	tumor necrosis factor	Homo sapiens	42-45
30521103-0	2019	Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33.	Chondroitin Sulfates	0-19	C-X-C motif chemokine ligand 8	Homo sapiens	50-55
30521103-0	2019	Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL-33.	Chondroitin Sulfates	0-19	interleukin 33	Homo sapiens	92-97
30521103-5	2019	Preincubation with CS had no effect on MC degranulation stimulated by SP, but inhibited TNF (60%) and CXCL8 (45%) secretion from LAD2 cells stimulated by IL-33.	Chondroitin Sulfates	19-21	tumor necrosis factor	Homo sapiens	88-91
30521103-5	2019	Preincubation with CS had no effect on MC degranulation stimulated by SP, but inhibited TNF (60%) and CXCL8 (45%) secretion from LAD2 cells stimulated by IL-33.	Chondroitin Sulfates	19-21	C-X-C motif chemokine ligand 8	Homo sapiens	102-107
30391802-6	2019	Chondroitin sulfate was necessary for load-inhibited hypertrophy and correlated with enhanced S100A4 expression, which is downstream of the osmotic responsive transcription factor NFAT5.	Chondroitin Sulfates	0-19	nuclear factor of activated T cells 5	Homo sapiens	180-185
30391802-8	2019	Findings from this study indicate that chondroitin sulfate with dynamic loading create physiochemical cues that support MSC chondrogenesis and attenuate hypertrophy through Smad 1/5/8 inhibition and p38 MAPK upregulation.	Chondroitin Sulfates	39-58	SMAD family member 1	Homo sapiens	173-181
30521103-5	2019	Preincubation with CS had no effect on MC degranulation stimulated by SP, but inhibited TNF (60%) and CXCL8 (45%) secretion from LAD2 cells stimulated by IL-33.	Chondroitin Sulfates	19-21	interleukin 33	Homo sapiens	154-159
30521103-7	2019	DS and Hep inhibited IL-33-stimulated secretion of TNF and CXCL8 to a similar extent as CS.	Chondroitin Sulfates	88-90	interleukin 33	Homo sapiens	21-26
30391802-8	2019	Findings from this study indicate that chondroitin sulfate with dynamic loading create physiochemical cues that support MSC chondrogenesis and attenuate hypertrophy through Smad 1/5/8 inhibition and p38 MAPK upregulation.	Chondroitin Sulfates	39-58	mitogen-activated protein kinase 14	Homo sapiens	199-202
30521103-12	2019	The findings in this article show that CS inhibits secretion of TNF and CXCL8 from human cultured MC stimulated by IL-33.	Chondroitin Sulfates	39-41	tumor necrosis factor	Homo sapiens	64-67
30521103-12	2019	The findings in this article show that CS inhibits secretion of TNF and CXCL8 from human cultured MC stimulated by IL-33.	Chondroitin Sulfates	39-41	C-X-C motif chemokine ligand 8	Homo sapiens	72-77
30521103-12	2019	The findings in this article show that CS inhibits secretion of TNF and CXCL8 from human cultured MC stimulated by IL-33.	Chondroitin Sulfates	39-41	interleukin 33	Homo sapiens	115-120
29984655-2	2019	OBJECTIVE: We hypothesized that structural alterations and expression levels of BGN, DCN and their associated chondroitin sulfate (CS) polymerizing enzymes, dermatan sulfate (DS) epimerases and various sulfatases might be correlated with the tumor (sub)type and patients" survival.	Chondroitin Sulfates	110-129	biglycan	Homo sapiens	80-83
31334040-0	2019	Chondroitin sulfate degradation and eicosanoid metabolism pathways are impaired in focal segmental glomerulosclerosis: Experimental confirmation of an in silico prediction.	Chondroitin Sulfates	0-19	actinin alpha 4	Homo sapiens	83-117
29984655-2	2019	OBJECTIVE: We hypothesized that structural alterations and expression levels of BGN, DCN and their associated chondroitin sulfate (CS) polymerizing enzymes, dermatan sulfate (DS) epimerases and various sulfatases might be correlated with the tumor (sub)type and patients" survival.	Chondroitin Sulfates	110-129	citrate synthase	Homo sapiens	131-133
31097363-5	2019	Here, we show that chondroitin sulfate strongly inhibits the catabolism of membrane-bound GM2 by beta-hexosaminidase A in presence of GM2 activator protein in vitro already at low micromolar concentrations.	Chondroitin Sulfates	19-38	O-GlcNAcase	Homo sapiens	97-116
30459452-0	2018	Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.	Chondroitin Sulfates	65-84	chondroitin sulfate synthase 1	Mus musculus	85-120
30459452-6	2018	The production of collagen type 1 was significantly downregulated in T1KO mice, and the deposition of CS-binding molecules, Wnt3a, was decreased with CS in extracellular matrices.	Chondroitin Sulfates	102-104	wingless-type MMTV integration site family, member 3A	Mus musculus	124-129
30459452-6	2018	The production of collagen type 1 was significantly downregulated in T1KO mice, and the deposition of CS-binding molecules, Wnt3a, was decreased with CS in extracellular matrices.	Chondroitin Sulfates	150-152	wingless-type MMTV integration site family, member 3A	Mus musculus	124-129
30825173-2	2019	They do so by the so-called Gouy-Chapman-Stern effect which is due to the electrical "masking" that certain ions, especially divalents, can exert onto the electrically negative charged polar heads of the membrane phospholipids.Chondroitin sulfates can chelate free calcium ions to a different extent based on the spatial arrangement of their sulfate groups and can thus alter the actual availability of screening divalent ions at the outer membrane surface.Voltage-dependent ion channels sense the actual potential difference between the two sides of the plasma membrane and are thus exquisite and extremely sensitive "devices" able to react to changes in the electrical potential across the membrane.Hence, by recording the shift in the activation curve of well-known voltage-dependent ionic channels it will be possible to study the physical effect of ECM chondroitin sulfates on membrane conductances.	Chondroitin Sulfates	227-247	multimerin 1	Homo sapiens	854-857
31097363-7	2019	On the other hand, hydrolysis of micellar-bound GM2 by beta-hexosaminidase A without the assistance of GM2AP was not impeded by chondroitin sulfate implicating that the inhibition of GM2 hydrolysis by chondroitin sulfate is most likely based on an interaction with GM2AP, the GM2AP-GM2 complex or the GM2-carrying membranes.	Chondroitin Sulfates	201-220	O-GlcNAcase	Homo sapiens	55-74
30305043-1	2018	BACKGROUND: Mucopolysaccharidosis-IVA (Morquio A disease) is a lysosomal disorder in which the abnormal accumulation of keratan sulfate and chondroitin-6-sulfate is consequent to mutations in the galactosamine-6-sulfatase (GALNS) gene.	Chondroitin Sulfates	140-161	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	196-221
30507075-0	2018	Novel nano-microspheres containing chitosan, hyaluronic acid, and chondroitin sulfate deliver growth and differentiation factor-5 plasmid for osteoarthritis gene therapy.	Chondroitin Sulfates	66-85	growth/differentiation factor 5	Oryctolagus cuniculus	94-129
30507075-1	2018	OBJECTIVE: To construct a novel non-viral vector loaded with growth and differentiation factor-5 (GDF-5) plasmid using chitosan, hyaluronic acid, and chondroitin sulfate for osteoarthritis (OA) gene therapy.	Chondroitin Sulfates	150-169	growth/differentiation factor 5	Oryctolagus cuniculus	61-96
30507075-1	2018	OBJECTIVE: To construct a novel non-viral vector loaded with growth and differentiation factor-5 (GDF-5) plasmid using chitosan, hyaluronic acid, and chondroitin sulfate for osteoarthritis (OA) gene therapy.	Chondroitin Sulfates	150-169	growth/differentiation factor 5	Oryctolagus cuniculus	98-103
30344756-3	2018	Chondroitin synthase-1 (CHSY1) is an enzyme responsible for the biosynthesis of chondroitin sulfate and has been implicated in the tumorigenesis of several cancer types; however, there is limited information regarding the role of CHSY1 in colorectal cancer.	Chondroitin Sulfates	80-99	chondroitin sulfate synthase 1	Homo sapiens	0-22
30344756-3	2018	Chondroitin synthase-1 (CHSY1) is an enzyme responsible for the biosynthesis of chondroitin sulfate and has been implicated in the tumorigenesis of several cancer types; however, there is limited information regarding the role of CHSY1 in colorectal cancer.	Chondroitin Sulfates	80-99	chondroitin sulfate synthase 1	Homo sapiens	24-29
30093041-5	2018	Further experiments showed that CS could increase the secretion levels of NO, TNF-alpha, IL-6 and IL-10 via activating the corresponding mRNA expression in macrophages through the toll-like receptor 2 (TLR2).	Chondroitin Sulfates	32-34	tumor necrosis factor	Mus musculus	78-87
30093041-5	2018	Further experiments showed that CS could increase the secretion levels of NO, TNF-alpha, IL-6 and IL-10 via activating the corresponding mRNA expression in macrophages through the toll-like receptor 2 (TLR2).	Chondroitin Sulfates	32-34	interleukin 6	Mus musculus	89-93
30093041-5	2018	Further experiments showed that CS could increase the secretion levels of NO, TNF-alpha, IL-6 and IL-10 via activating the corresponding mRNA expression in macrophages through the toll-like receptor 2 (TLR2).	Chondroitin Sulfates	32-34	interleukin 10	Mus musculus	98-103
30093041-5	2018	Further experiments showed that CS could increase the secretion levels of NO, TNF-alpha, IL-6 and IL-10 via activating the corresponding mRNA expression in macrophages through the toll-like receptor 2 (TLR2).	Chondroitin Sulfates	32-34	toll-like receptor 2	Mus musculus	180-200
30093041-5	2018	Further experiments showed that CS could increase the secretion levels of NO, TNF-alpha, IL-6 and IL-10 via activating the corresponding mRNA expression in macrophages through the toll-like receptor 2 (TLR2).	Chondroitin Sulfates	32-34	toll-like receptor 2	Mus musculus	202-206
30305043-1	2018	BACKGROUND: Mucopolysaccharidosis-IVA (Morquio A disease) is a lysosomal disorder in which the abnormal accumulation of keratan sulfate and chondroitin-6-sulfate is consequent to mutations in the galactosamine-6-sulfatase (GALNS) gene.	Chondroitin Sulfates	140-161	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	223-228
30335002-1	2018	RATIONALE: Mucopolysaccharidosis type VI (MPS VI) or Maroteaux-Lamy syndrome is produced by the deficiency of the enzyme arylsulfatase B, responsible for the hydrolysis of N-acetyl-D-galactosamine, chondroitin sulfate, and dermatan sulfate.	Chondroitin Sulfates	198-217	arylsulfatase B	Homo sapiens	121-136
29702175-4	2018	Chondroitin sulfate proteoglycans integrate signals from the microenvironment to activate immune cells, and they boost inflammatory responses by binding immunological receptors including toll-like receptors, selectins, CD44, and beta1 integrin.	Chondroitin Sulfates	0-19	CD44 molecule (Indian blood group)	Homo sapiens	219-223
29702175-4	2018	Chondroitin sulfate proteoglycans integrate signals from the microenvironment to activate immune cells, and they boost inflammatory responses by binding immunological receptors including toll-like receptors, selectins, CD44, and beta1 integrin.	Chondroitin Sulfates	0-19	integrin subunit beta 1	Homo sapiens	229-243
30125508-2	2018	This strategy has proven to employ chondroitin sulfate- g-taurocholic acid coated, insulin-loaded partially uncapped liposome (IPUL-CST) for type 1 diabetes mellitus (T1DM) treatment.	Chondroitin Sulfates	35-54	insulin	Homo sapiens	83-90
30191764-2	2018	METHODS: We developed a lactoferrin-chondroitin sulfate nanocomplex for the co-delivery of doxorubicin and ellagic acid nanocrystals to lung cancer cells.	Chondroitin Sulfates	36-55	lactotransferrin	Mus musculus	24-35
30126967-12	2018	These findings indicate that CSPG is involved in the regulation of adult hippocampal neurogenesis and suggest that increased synthesis of CSPG by CSGalNacT1 may mediate promotion of granule cell production and improvement of cognitive memory in response to EE.SIGNIFICANCE STATEMENT Chondroitin sulfate proteoglycan (CSPG) is a candidate regulator of embryonic neurogenesis.	Chondroitin Sulfates	283-302	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	146-156
30016638-11	2018	These results demonstrated that ECM remodeling during tumor progression increased CS chains to facilitate EMT and ABCB1 upregulation, contributing to chemoresistance acquisition.	Chondroitin Sulfates	82-84	ATP binding cassette subfamily B member 1	Homo sapiens	114-119
29733455-6	2018	CXCL9(74-103) competes with CXCL6 and CCL3 for binding to the glycosaminoglycans heparan sulfate and chondroitin sulfate in vitro.	Chondroitin Sulfates	101-120	chemokine (C-X-C motif) ligand 9	Mus musculus	0-5
29733455-6	2018	CXCL9(74-103) competes with CXCL6 and CCL3 for binding to the glycosaminoglycans heparan sulfate and chondroitin sulfate in vitro.	Chondroitin Sulfates	101-120	chemokine (C-X-C motif) ligand 5	Mus musculus	28-33
29733455-6	2018	CXCL9(74-103) competes with CXCL6 and CCL3 for binding to the glycosaminoglycans heparan sulfate and chondroitin sulfate in vitro.	Chondroitin Sulfates	101-120	chemokine (C-C motif) ligand 3	Mus musculus	38-42
29481844-8	2018	One widely expressed form is biglycan proteoglycan (PG) that bears two chondroitin sulfate GAG chains (typically chondroitin sulfate) and two N-linked carbohydrates.	Chondroitin Sulfates	71-90	biglycan	Mus musculus	29-37
30233568-6	2018	However, nitration significantly enhanced the affinity of CXCL12 for chondroitin sulfate.	Chondroitin Sulfates	69-88	C-X-C motif chemokine ligand 12	Homo sapiens	58-64
30148873-13	2018	These findings suggest that Neurotropin may activate the phosphatidylinositol 3-kinase-AKT pathway and stimulate glycosaminoglycan synthesis through upregulation of expression of mRNA for chondroitin sulfate N-acetylgalactosaminyltransferase 1.	Chondroitin Sulfates	188-207	AKT serine/threonine kinase 1	Homo sapiens	87-90
30019359-6	2018	P11 -4 and P11 -8-chondroitin sulphate mixtures, at both molar ratios, were shown to have a high beta-sheet percentage, dense entangled fibrillar networks, as well as high mechanical stiffness in both (130 and 230 mM) Na+ salt solutions when compared with the P11 -12/chondroitin sulphate mixtures.	Chondroitin Sulfates	18-38	endonuclease, poly(U) specific	Homo sapiens	0-3
30019359-6	2018	P11 -4 and P11 -8-chondroitin sulphate mixtures, at both molar ratios, were shown to have a high beta-sheet percentage, dense entangled fibrillar networks, as well as high mechanical stiffness in both (130 and 230 mM) Na+ salt solutions when compared with the P11 -12/chondroitin sulphate mixtures.	Chondroitin Sulfates	18-38	endonuclease, poly(U) specific	Homo sapiens	11-14
30019359-6	2018	P11 -4 and P11 -8-chondroitin sulphate mixtures, at both molar ratios, were shown to have a high beta-sheet percentage, dense entangled fibrillar networks, as well as high mechanical stiffness in both (130 and 230 mM) Na+ salt solutions when compared with the P11 -12/chondroitin sulphate mixtures.	Chondroitin Sulfates	18-38	endonuclease, poly(U) specific	Homo sapiens	11-14
30191764-7	2018	CONCLUSION: Overall, inhalable lactoferrin-chondroitin sulfate nanocomposites would be a promising carrier for targeted drug delivery to lung cancer.	Chondroitin Sulfates	43-62	lactotransferrin	Mus musculus	31-42
29794138-4	2018	Here, we show that SHP2 binds preferentially C4S, rather than chondroitin 6-sulfate, and confirm that SHP2 activity declines when ARSB is silenced.	Chondroitin Sulfates	45-48	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	19-23
29512121-10	2018	Paradoxically, ketorolac increased the release of CXCL1 and IL-8 in prostaglandin E2 and chondroitin sulphate-stimulated synovial cells in vitro.	Chondroitin Sulfates	89-109	C-X-C motif chemokine ligand 1	Homo sapiens	50-55
30022822-3	2018	Methods: In this study, HA- and CD-modified poly(D,L-lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) copolymers were synthesized and applied to encapsulate 1,2-Dioleoyl-3-trimethylammonium-propane (DOTAP)/pDNA (D/P) lipoplex as CD44 receptor targeting gene delivery nanoparticles (NPs).	Chondroitin Sulfates	32-34	CD44 antigen	Mus musculus	235-239
29512121-10	2018	Paradoxically, ketorolac increased the release of CXCL1 and IL-8 in prostaglandin E2 and chondroitin sulphate-stimulated synovial cells in vitro.	Chondroitin Sulfates	89-109	C-X-C motif chemokine ligand 8	Homo sapiens	60-64
29661321-1	2018	Chondroitin sulfate (CS) sulfation-dependently binds transforming growth factor-beta1 (TGF-beta1) and chronic wounds often accompany with epidermal hyperproliferation due to downregulated TGF-beta signaling.	Chondroitin Sulfates	0-19	transforming growth factor beta 1	Homo sapiens	53-85
29661321-1	2018	Chondroitin sulfate (CS) sulfation-dependently binds transforming growth factor-beta1 (TGF-beta1) and chronic wounds often accompany with epidermal hyperproliferation due to downregulated TGF-beta signaling.	Chondroitin Sulfates	0-19	transforming growth factor beta 1	Homo sapiens	87-96
29661321-1	2018	Chondroitin sulfate (CS) sulfation-dependently binds transforming growth factor-beta1 (TGF-beta1) and chronic wounds often accompany with epidermal hyperproliferation due to downregulated TGF-beta signaling.	Chondroitin Sulfates	0-19	transforming growth factor beta 1	Homo sapiens	87-95
29661321-1	2018	Chondroitin sulfate (CS) sulfation-dependently binds transforming growth factor-beta1 (TGF-beta1) and chronic wounds often accompany with epidermal hyperproliferation due to downregulated TGF-beta signaling.	Chondroitin Sulfates	21-23	transforming growth factor beta 1	Homo sapiens	53-85
29661321-1	2018	Chondroitin sulfate (CS) sulfation-dependently binds transforming growth factor-beta1 (TGF-beta1) and chronic wounds often accompany with epidermal hyperproliferation due to downregulated TGF-beta signaling.	Chondroitin Sulfates	21-23	transforming growth factor beta 1	Homo sapiens	87-96
29661321-1	2018	Chondroitin sulfate (CS) sulfation-dependently binds transforming growth factor-beta1 (TGF-beta1) and chronic wounds often accompany with epidermal hyperproliferation due to downregulated TGF-beta signaling.	Chondroitin Sulfates	21-23	transforming growth factor beta 1	Homo sapiens	87-95
29661321-4	2018	Thus, this study aims to evaluate the effects of CS derivatives on the interaction with vascular endothelial growth factor-A (VEGF-A) and on keratinocyte response.	Chondroitin Sulfates	49-51	vascular endothelial growth factor A	Homo sapiens	88-124
29661321-4	2018	Thus, this study aims to evaluate the effects of CS derivatives on the interaction with vascular endothelial growth factor-A (VEGF-A) and on keratinocyte response.	Chondroitin Sulfates	49-51	vascular endothelial growth factor A	Homo sapiens	126-132
29661321-5	2018	Over-sulfated CS (sCS3) interacts stronger with VEGF-A than CS.	Chondroitin Sulfates	14-16	vascular endothelial growth factor A	Homo sapiens	48-54
29661321-5	2018	Over-sulfated CS (sCS3) interacts stronger with VEGF-A than CS.	Chondroitin Sulfates	19-21	vascular endothelial growth factor A	Homo sapiens	48-54
29420785-2	2018	Both chondroitin sulphate (CS) and heparan sulphate (HS) are important constituents of GAG ligands for RPTPsigma, although they have opposite effects on neuronal cells.	Chondroitin Sulfates	5-25	protein tyrosine phosphatase receptor type S	Homo sapiens	103-112
29420785-2	2018	Both chondroitin sulphate (CS) and heparan sulphate (HS) are important constituents of GAG ligands for RPTPsigma, although they have opposite effects on neuronal cells.	Chondroitin Sulfates	27-29	protein tyrosine phosphatase receptor type S	Homo sapiens	103-112
29420785-3	2018	CS inhibits neurite outgrowth and neural regeneration through RPTPsigma, whereas HS enhances them.	Chondroitin Sulfates	0-2	protein tyrosine phosphatase receptor type S	Homo sapiens	62-71
29420785-4	2018	We prepared recombinant RPTPsigma N-terminal fragment containing the GAG binding site and various types of biotin-conjugated GAG (CS and HS) with chemical modification and chemo-enzymatic synthesis.	Chondroitin Sulfates	130-132	protein tyrosine phosphatase receptor type S	Homo sapiens	24-33
29420785-6	2018	Interaction of RPTPsigma with the CS library was highly correlated to the degree of disulphated disaccharide E unit, which had two sulphate groups at C-4 and C-6 positions of the N-acetylgalactosamine residue (CSE).	Chondroitin Sulfates	34-36	protein tyrosine phosphatase receptor type S	Homo sapiens	15-24
29874688-0	2018	Chondroitin Sulphate Attenuates Atherosclerosis in ApoE Knockout Mice Involving Cellular Regulation of the Inflammatory Response.	Chondroitin Sulfates	0-20	apolipoprotein E	Mus musculus	51-55
29874688-6	2018	ApoE knockout mice treated with CS exhibited attenuated atheroma lesion size by 68% as compared with animals receiving vehicle.	Chondroitin Sulfates	32-34	apolipoprotein E	Mus musculus	0-4
29874688-9	2018	CS reduced the expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1 and ephrin-B2 and improved the migration of inflamed endothelial cells.	Chondroitin Sulfates	0-2	vascular cell adhesion molecule 1	Mus musculus	29-97
29874688-9	2018	CS reduced the expression of vascular cell adhesion molecule 1, intercellular adhesion molecule 1 and ephrin-B2 and improved the migration of inflamed endothelial cells.	Chondroitin Sulfates	0-2	ephrin B2	Mus musculus	102-111
29904116-4	2018	Breast cancer cells depleted of heparan sulfate or chondroitin sulfate glycosaminoglycans lose their ability to induce APRIL secretion from neutrophils, and heparan sulfate and chondroitin sulfate can induce secretion that is comparable to that of breast cancer cell-induced secretion.	Chondroitin Sulfates	51-70	TNF superfamily member 13	Homo sapiens	119-124
29904116-6	2018	Thus, apart from the putative role of cell surface heparan sulfate in binding APRIL that leads to cell growth, we demonstrate that heparan sulfate, as well as chondroitin sulfate plays a novel role in promoting neutrophil secretion of APRIL that could lead to further cell growth.	Chondroitin Sulfates	159-178	TNF superfamily member 13	Homo sapiens	235-240
29864158-3	2018	Dermatan sulfate epimerase 1 (DSE) is overexpressed in many types of cancer, and CS/DS chains mediate several growth factor signals.	Chondroitin Sulfates	81-83	dermatan sulfate epimerase	Mus musculus	30-33
29462330-3	2018	CSPG4 from the two melanoma cell lines differed in the amount of chondroitin sulphate (CS) decoration, as well as the way the protein core was fragmented.	Chondroitin Sulfates	65-85	chondroitin sulfate proteoglycan 4	Homo sapiens	0-5
29371215-2	2018	In the monogenic disease mucopolysaccharidosis VI, loss-of-function mutations in arylsulfatase B lead to myocardial accumulation of chondroitin sulfate (CS) glycosaminoglycans, manifesting as myriad cardiac symptoms.	Chondroitin Sulfates	132-151	arylsulfatase B	Homo sapiens	81-96
29371215-2	2018	In the monogenic disease mucopolysaccharidosis VI, loss-of-function mutations in arylsulfatase B lead to myocardial accumulation of chondroitin sulfate (CS) glycosaminoglycans, manifesting as myriad cardiac symptoms.	Chondroitin Sulfates	153-155	arylsulfatase B	Homo sapiens	81-96
29371215-16	2018	Tumor necrosis factor-alpha was identified as a direct binding partner of CS glycosaminoglycan chains, and rhASB reduced tumor necrosis factor-alpha-induced inflammatory gene activation in vitro in endothelial cells and macrophages.	Chondroitin Sulfates	74-76	tumor necrosis factor	Homo sapiens	0-27
29565434-1	2018	Triple-negative breast cancer (TNBC) and malignant melanoma are highly aggressive cancers that widely express the cell surface chondroitin sulfate proteoglycan 4 (CSPG4/NG2).	Chondroitin Sulfates	127-146	proteoglycan 4	Homo sapiens	147-161
29565434-1	2018	Triple-negative breast cancer (TNBC) and malignant melanoma are highly aggressive cancers that widely express the cell surface chondroitin sulfate proteoglycan 4 (CSPG4/NG2).	Chondroitin Sulfates	127-146	chondroitin sulfate proteoglycan 4	Homo sapiens	163-168
29565434-1	2018	Triple-negative breast cancer (TNBC) and malignant melanoma are highly aggressive cancers that widely express the cell surface chondroitin sulfate proteoglycan 4 (CSPG4/NG2).	Chondroitin Sulfates	127-146	chondroitin sulfate proteoglycan 4	Homo sapiens	169-172
30139714-4	2018	On day 21, phosphorylation of spinal p38 mitogen-activated protein kinase (MAPK) was attenuated by CS.	Chondroitin Sulfates	99-101	mitogen-activated protein kinase 14	Mus musculus	37-40
30139714-5	2018	CS also inhibited c-Fos upregulation in ipsilateral deep dorsal horn (laminae III-IV) neurons, which receive Abeta-fiber afferent inputs.	Chondroitin Sulfates	0-2	FBJ osteosarcoma oncogene	Mus musculus	18-23
30139714-6	2018	These findings suggest that CS attenuates PSNL-induced tactile allodynia by inhibiting spinal p38 MAPK phosphorylation and Abeta-fiber activation.	Chondroitin Sulfates	28-30	mitogen-activated protein kinase 14	Mus musculus	94-97
29570275-2	2018	Glycosaminoglycan chains, including heparan sulfate (HS) and chondroitin sulfate (CS), act as ligands that regulate LAR signaling.	Chondroitin Sulfates	61-80	protein tyrosine phosphatase receptor type F	Homo sapiens	116-119
29570275-2	2018	Glycosaminoglycan chains, including heparan sulfate (HS) and chondroitin sulfate (CS), act as ligands that regulate LAR signaling.	Chondroitin Sulfates	82-84	protein tyrosine phosphatase receptor type F	Homo sapiens	116-119
29547718-2	2018	(2018) report that chondroitin-4-sulfate, which is found in a common supplement meant to alleviate degenerative joint disorders, promotes the growth of BRAF V600E mutant melanoma.	Chondroitin Sulfates	19-40	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	152-156
29539424-4	2018	The data support a pathogenic mechanism where TGF-ss signals enhance the proteolytic processing of pro-Ctsk by modulating the expression of chondroitin 4-sulfate (C4-S).	Chondroitin Sulfates	140-161	cathepsin K	Danio rerio	103-107
29539424-4	2018	The data support a pathogenic mechanism where TGF-ss signals enhance the proteolytic processing of pro-Ctsk by modulating the expression of chondroitin 4-sulfate (C4-S).	Chondroitin Sulfates	163-167	cathepsin K	Danio rerio	103-107
29539424-5	2018	In MLII, elevated C4-S corresponds with TGF-ss-mediated increases in chst11 expression.	Chondroitin Sulfates	18-22	carbohydrate (chondroitin 4) sulfotransferase 11	Danio rerio	69-75
29355717-0	2018	Localization and promotion of recombinant human bone morphogenetic protein-2 bioactivity on extracellular matrix mimetic chondroitin sulfate-functionalized calcium phosphate cement scaffolds.	Chondroitin Sulfates	121-140	bone morphogenetic protein 2	Homo sapiens	48-76
29355717-9	2018	STATEMENT OF SIGNIFICANCE: A bioinspired chondroitin sulfate (CS)-functionalized calcium phosphate cement (CPC) platform was developed to tether recombinant human bone morphogenetic protein-2 (rhBMP-2), which could exhibit continuous, long-term, and effective osteogenic stimulation in bone tissue engineering.	Chondroitin Sulfates	41-60	bone morphogenetic protein 2	Homo sapiens	163-191
29355717-9	2018	STATEMENT OF SIGNIFICANCE: A bioinspired chondroitin sulfate (CS)-functionalized calcium phosphate cement (CPC) platform was developed to tether recombinant human bone morphogenetic protein-2 (rhBMP-2), which could exhibit continuous, long-term, and effective osteogenic stimulation in bone tissue engineering.	Chondroitin Sulfates	62-64	bone morphogenetic protein 2	Homo sapiens	163-191
28477140-3	2018	The CSPG glycosaminoglycan side chains composed of chondroitin sulfate (CS) are responsible for its inhibitory activity on neurite outgrowth and are dependent on RhoA activation.	Chondroitin Sulfates	4-6	ras homolog family member A	Homo sapiens	162-166
29561763-0	2018	212Pb-Labeled Antibody 225.28 Targeted to Chondroitin Sulfate Proteoglycan 4 for Triple-Negative Breast Cancer Therapy in Mouse Models.	Chondroitin Sulfates	42-61	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)	Mus musculus	62-76
29352946-3	2018	Interestingly, nanoparticles were demonstrated to respond to hyaluronidase-1 (Hyal-1) which could degrade chondroitin sulfate (CS) backbones.	Chondroitin Sulfates	106-125	hyaluronidase 1	Homo sapiens	61-76
29352946-3	2018	Interestingly, nanoparticles were demonstrated to respond to hyaluronidase-1 (Hyal-1) which could degrade chondroitin sulfate (CS) backbones.	Chondroitin Sulfates	106-125	hyaluronidase 1	Homo sapiens	78-84
29352946-3	2018	Interestingly, nanoparticles were demonstrated to respond to hyaluronidase-1 (Hyal-1) which could degrade chondroitin sulfate (CS) backbones.	Chondroitin Sulfates	127-129	hyaluronidase 1	Homo sapiens	61-76
29352946-3	2018	Interestingly, nanoparticles were demonstrated to respond to hyaluronidase-1 (Hyal-1) which could degrade chondroitin sulfate (CS) backbones.	Chondroitin Sulfates	127-129	hyaluronidase 1	Homo sapiens	78-84
29547721-0	2018	The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells.	Chondroitin Sulfates	23-44	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	93-97
29547721-3	2018	Here we report that chondroitin-4-sulfate (CHSA), a natural glycosaminoglycan approved as a dietary supplement used for osteoarthritis, selectively promotes the tumor growth potential of BRAF V600E-expressing human melanoma cells in patient- and cell line-derived xenograft mice and confers resistance to BRAF inhibitors.	Chondroitin Sulfates	20-41	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	187-191
29547721-3	2018	Here we report that chondroitin-4-sulfate (CHSA), a natural glycosaminoglycan approved as a dietary supplement used for osteoarthritis, selectively promotes the tumor growth potential of BRAF V600E-expressing human melanoma cells in patient- and cell line-derived xenograft mice and confers resistance to BRAF inhibitors.	Chondroitin Sulfates	20-41	Braf transforming gene	Mus musculus	305-309
29547721-3	2018	Here we report that chondroitin-4-sulfate (CHSA), a natural glycosaminoglycan approved as a dietary supplement used for osteoarthritis, selectively promotes the tumor growth potential of BRAF V600E-expressing human melanoma cells in patient- and cell line-derived xenograft mice and confers resistance to BRAF inhibitors.	Chondroitin Sulfates	43-47	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	187-191
29547721-3	2018	Here we report that chondroitin-4-sulfate (CHSA), a natural glycosaminoglycan approved as a dietary supplement used for osteoarthritis, selectively promotes the tumor growth potential of BRAF V600E-expressing human melanoma cells in patient- and cell line-derived xenograft mice and confers resistance to BRAF inhibitors.	Chondroitin Sulfates	43-47	Braf transforming gene	Mus musculus	305-309
29439742-0	2018	The chondroitin sulfate moiety mediates thrombomodulin-enhanced adhesion and migration of vascular smooth muscle cells.	Chondroitin Sulfates	4-23	thrombomodulin	Homo sapiens	40-54
29439742-9	2018	Furthermore, the TM mutant (TMS490, 492A) devoid of CS moiety failed to increase cell adhesion, spreading or migration.	Chondroitin Sulfates	52-54	thrombomodulin	Homo sapiens	17-19
29439742-11	2018	CONCLUSION: Chondroitin sulfate modification is required for TM-mediated activation of beta1-integrin and FAK, thereby enhancing adhesion and migration activity of VSMCs.	Chondroitin Sulfates	12-31	thrombomodulin	Homo sapiens	61-63
29439742-11	2018	CONCLUSION: Chondroitin sulfate modification is required for TM-mediated activation of beta1-integrin and FAK, thereby enhancing adhesion and migration activity of VSMCs.	Chondroitin Sulfates	12-31	integrin subunit beta 1	Homo sapiens	87-101
29439742-11	2018	CONCLUSION: Chondroitin sulfate modification is required for TM-mediated activation of beta1-integrin and FAK, thereby enhancing adhesion and migration activity of VSMCs.	Chondroitin Sulfates	12-31	protein tyrosine kinase 2	Homo sapiens	106-109
29568569-5	2018	Results: One such material, synthesized from chondroitin sulfate type A and serotonin in the presence of Cu2+ was found to affect the release of IL-1beta and IL-6 cytokines from immune cells.	Chondroitin Sulfates	45-64	interleukin 1 beta	Homo sapiens	145-153
29541644-4	2018	UTI was separated from the main glycosaminoglycans physiologically present in urine by anion exchange chromatography, treated for chondroitin sulphate (CS) chain complete depolymerisation, and analysed for both UTI content and CS structure.	Chondroitin Sulfates	130-150	alpha-1-microglobulin/bikunin precursor	Homo sapiens	0-3
29541644-4	2018	UTI was separated from the main glycosaminoglycans physiologically present in urine by anion exchange chromatography, treated for chondroitin sulphate (CS) chain complete depolymerisation, and analysed for both UTI content and CS structure.	Chondroitin Sulfates	152-154	alpha-1-microglobulin/bikunin precursor	Homo sapiens	0-3
29541644-4	2018	UTI was separated from the main glycosaminoglycans physiologically present in urine by anion exchange chromatography, treated for chondroitin sulphate (CS) chain complete depolymerisation, and analysed for both UTI content and CS structure.	Chondroitin Sulfates	227-229	alpha-1-microglobulin/bikunin precursor	Homo sapiens	0-3
29434726-2	2018	The chondroitin sulfate region of three APOE alleles (epsilon2, epsilon3 and epsilon4) was obtained by reverse transcription-polymerase chain reaction (RT-PCR).	Chondroitin Sulfates	4-23	apolipoprotein E	Mus musculus	40-44
29568569-5	2018	Results: One such material, synthesized from chondroitin sulfate type A and serotonin in the presence of Cu2+ was found to affect the release of IL-1beta and IL-6 cytokines from immune cells.	Chondroitin Sulfates	45-64	interleukin 6	Homo sapiens	158-162
29183998-0	2018	Chondroitin sulfate-mediated N-cadherin/beta-catenin signaling is associated with basal-like breast cancer cell invasion.	Chondroitin Sulfates	0-19	cadherin 2	Homo sapiens	29-39
29183998-0	2018	Chondroitin sulfate-mediated N-cadherin/beta-catenin signaling is associated with basal-like breast cancer cell invasion.	Chondroitin Sulfates	0-19	catenin beta 1	Homo sapiens	40-52
29183998-5	2018	CSs interacted with and induced proteolytic cleavage of N-cadherin in the BT-549 cells, yielding a C-terminal intracellular N-cadherin fragment that formed a complex with beta-catenin.	Chondroitin Sulfates	0-3	cadherin 2	Homo sapiens	56-66
29183998-5	2018	CSs interacted with and induced proteolytic cleavage of N-cadherin in the BT-549 cells, yielding a C-terminal intracellular N-cadherin fragment that formed a complex with beta-catenin.	Chondroitin Sulfates	0-3	cadherin 2	Homo sapiens	124-134
29183998-5	2018	CSs interacted with and induced proteolytic cleavage of N-cadherin in the BT-549 cells, yielding a C-terminal intracellular N-cadherin fragment that formed a complex with beta-catenin.	Chondroitin Sulfates	0-3	catenin beta 1	Homo sapiens	171-183
29183998-7	2018	We also found that CS-induced N-cadherin proteolysis requires caveolae-mediated endocytosis.	Chondroitin Sulfates	19-21	cadherin 2	Homo sapiens	30-40
29183998-8	2018	An inhibitor of that process, nystatin, blocked both the endocytosis and proteolytic cleavage of N-cadherin induced by CS and also suppressed BT-549 cell invasion.	Chondroitin Sulfates	119-121	cadherin 2	Homo sapiens	97-107
29183998-9	2018	Knock-out of chondroitin 4-O-sulfotransferase-1 (C4ST-1), a key CS biosynthetic enzyme, suppressed activation of the N-cadherin/beta-catenin pathway through N-cadherin endocytosis and significantly decreased BT-549 cell invasion.	Chondroitin Sulfates	64-66	carbohydrate sulfotransferase 11	Homo sapiens	13-47
29183998-9	2018	Knock-out of chondroitin 4-O-sulfotransferase-1 (C4ST-1), a key CS biosynthetic enzyme, suppressed activation of the N-cadherin/beta-catenin pathway through N-cadherin endocytosis and significantly decreased BT-549 cell invasion.	Chondroitin Sulfates	64-66	carbohydrate sulfotransferase 11	Homo sapiens	49-55
29183998-9	2018	Knock-out of chondroitin 4-O-sulfotransferase-1 (C4ST-1), a key CS biosynthetic enzyme, suppressed activation of the N-cadherin/beta-catenin pathway through N-cadherin endocytosis and significantly decreased BT-549 cell invasion.	Chondroitin Sulfates	64-66	catenin beta 1	Homo sapiens	128-140
29183998-10	2018	These results suggest that CSs produced by C4ST-1 might be useful therapeutic targets in the management of basal-like breast cancers.	Chondroitin Sulfates	27-30	carbohydrate sulfotransferase 11	Homo sapiens	43-49
29063236-9	2018	WIKIPATHWAYS, REACTOME, PID_NCI and KEGG pathway analysis showed the down-regulated DEGs were enriched endochondral ossification, TGF beta signalling pathway, integrin cell surface interactions, beta1 integrin cell surface interactions, malaria and glycosaminoglycan biosynthesis-chondroitin sulfate/dermatan sulphate.	Chondroitin Sulfates	280-299	transforming growth factor beta 1	Homo sapiens	130-138
29063236-9	2018	WIKIPATHWAYS, REACTOME, PID_NCI and KEGG pathway analysis showed the down-regulated DEGs were enriched endochondral ossification, TGF beta signalling pathway, integrin cell surface interactions, beta1 integrin cell surface interactions, malaria and glycosaminoglycan biosynthesis-chondroitin sulfate/dermatan sulphate.	Chondroitin Sulfates	280-299	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	195-200
28846826-5	2017	Recent studies have implicated anti-PF4 antibodies that are able to bridge two PF4 tetramers even in the absence of heparin, probably facilitated by non-heparin platelet-associated polyanions (chondroitin sulfate and polyphosphates); nascent PF4-aHIT-IgG complexes recruit additional heparin-dependent HIT antibodies, leading to the formation of large multimolecular immune complexes and marked platelet activation.	Chondroitin Sulfates	193-212	platelet factor 4	Homo sapiens	36-39
30121667-1	2018	BACKGROUND/AIMS: The chondroitin sulfate proteoglycan serglycin (SRGN), a hematopoietic cell granule proteoglycan, has been implicated in promoting tumor metastasis; however, the underlying mechanisms remain to be elucidated.	Chondroitin Sulfates	21-40	serglycin	Homo sapiens	54-63
30121667-1	2018	BACKGROUND/AIMS: The chondroitin sulfate proteoglycan serglycin (SRGN), a hematopoietic cell granule proteoglycan, has been implicated in promoting tumor metastasis; however, the underlying mechanisms remain to be elucidated.	Chondroitin Sulfates	21-40	serglycin	Homo sapiens	65-69
28608941-1	2018	The enzyme chondroitin polymerizing factor (ChPF) is primarily involved in extension of the chondroitin sulfate backbone required for the synthesis of sulfated glycosaminoglycan (sGAG).	Chondroitin Sulfates	92-111	chondroitin polymerizing factor	Homo sapiens	11-42
28608941-1	2018	The enzyme chondroitin polymerizing factor (ChPF) is primarily involved in extension of the chondroitin sulfate backbone required for the synthesis of sulfated glycosaminoglycan (sGAG).	Chondroitin Sulfates	92-111	chondroitin polymerizing factor	Homo sapiens	44-48
29178990-8	2018	Sixteen conserved, rare missense and nonsense variants in genes involved in CS metabolism (CHPF, CHPF2, CHST3, CHST12, CHST15, SLC26A2, PAPSS2, STAB2) were identified in over one-third of the TS patients.	Chondroitin Sulfates	76-78	chondroitin polymerizing factor	Homo sapiens	91-95
29178990-8	2018	Sixteen conserved, rare missense and nonsense variants in genes involved in CS metabolism (CHPF, CHPF2, CHST3, CHST12, CHST15, SLC26A2, PAPSS2, STAB2) were identified in over one-third of the TS patients.	Chondroitin Sulfates	76-78	chondroitin polymerizing factor 2	Homo sapiens	97-102
29178990-8	2018	Sixteen conserved, rare missense and nonsense variants in genes involved in CS metabolism (CHPF, CHPF2, CHST3, CHST12, CHST15, SLC26A2, PAPSS2, STAB2) were identified in over one-third of the TS patients.	Chondroitin Sulfates	76-78	solute carrier family 26 member 2	Homo sapiens	127-134
29178990-8	2018	Sixteen conserved, rare missense and nonsense variants in genes involved in CS metabolism (CHPF, CHPF2, CHST3, CHST12, CHST15, SLC26A2, PAPSS2, STAB2) were identified in over one-third of the TS patients.	Chondroitin Sulfates	76-78	3'-phosphoadenosine 5'-phosphosulfate synthase 2	Homo sapiens	136-142
29081414-1	2017	BACKGROUND: Arylsulfatase B (ARSB) removes the 4-sulfate group from chondroitin 4-sulfate (C4S) and dermatan sulfate and is required for their degradation.	Chondroitin Sulfates	68-89	arylsulfatase B	Homo sapiens	12-27
29081414-1	2017	BACKGROUND: Arylsulfatase B (ARSB) removes the 4-sulfate group from chondroitin 4-sulfate (C4S) and dermatan sulfate and is required for their degradation.	Chondroitin Sulfates	68-89	arylsulfatase B	Homo sapiens	29-33
29081414-1	2017	BACKGROUND: Arylsulfatase B (ARSB) removes the 4-sulfate group from chondroitin 4-sulfate (C4S) and dermatan sulfate and is required for their degradation.	Chondroitin Sulfates	91-94	arylsulfatase B	Homo sapiens	12-27
29081414-1	2017	BACKGROUND: Arylsulfatase B (ARSB) removes the 4-sulfate group from chondroitin 4-sulfate (C4S) and dermatan sulfate and is required for their degradation.	Chondroitin Sulfates	91-94	arylsulfatase B	Homo sapiens	29-33
28522399-8	2017	Additionally, a marked increase of proFLG-mRNA expression was observed in 0.05%sacran group (vs. control 0.05% CS and 0.5% PD groups).	Chondroitin Sulfates	111-113	filaggrin	Mus musculus	35-41
28990084-0	2017	Neuroprotective effect of chondroitin sulfate on SH-SY5Y cells overexpressing wild-type or A53T mutant alpha-synuclein.	Chondroitin Sulfates	26-45	synuclein alpha	Homo sapiens	103-118
28990084-7	2017	It was observed that CS reduced the expression levels of total alpha-SYN and phosphorylated Ser129 alpha-SYN, prevented cell loss and inhibited apoptosis.	Chondroitin Sulfates	21-23	synuclein alpha	Homo sapiens	63-72
28990084-7	2017	It was observed that CS reduced the expression levels of total alpha-SYN and phosphorylated Ser129 alpha-SYN, prevented cell loss and inhibited apoptosis.	Chondroitin Sulfates	21-23	synuclein alpha	Homo sapiens	99-108
28990084-9	2017	CS also significantly attenuated WT and A53T mutant alpha-SYN-induced dysfunction, including decrease of mitochondrial membrane potential, decrease of Bcl-2 expression, and increase of Bax expression, release of Cyt-c from the mitochondria and activation of caspase-3 and caspase-9, which demonstrated that CS suppressed alpha-SYN-induced apoptosis possibly through mitochondria protection.	Chondroitin Sulfates	0-2	synuclein alpha	Homo sapiens	52-61
28990084-9	2017	CS also significantly attenuated WT and A53T mutant alpha-SYN-induced dysfunction, including decrease of mitochondrial membrane potential, decrease of Bcl-2 expression, and increase of Bax expression, release of Cyt-c from the mitochondria and activation of caspase-3 and caspase-9, which demonstrated that CS suppressed alpha-SYN-induced apoptosis possibly through mitochondria protection.	Chondroitin Sulfates	0-2	BCL2 apoptosis regulator	Homo sapiens	151-156
28990084-9	2017	CS also significantly attenuated WT and A53T mutant alpha-SYN-induced dysfunction, including decrease of mitochondrial membrane potential, decrease of Bcl-2 expression, and increase of Bax expression, release of Cyt-c from the mitochondria and activation of caspase-3 and caspase-9, which demonstrated that CS suppressed alpha-SYN-induced apoptosis possibly through mitochondria protection.	Chondroitin Sulfates	0-2	BCL2 associated X, apoptosis regulator	Homo sapiens	185-188
28990084-9	2017	CS also significantly attenuated WT and A53T mutant alpha-SYN-induced dysfunction, including decrease of mitochondrial membrane potential, decrease of Bcl-2 expression, and increase of Bax expression, release of Cyt-c from the mitochondria and activation of caspase-3 and caspase-9, which demonstrated that CS suppressed alpha-SYN-induced apoptosis possibly through mitochondria protection.	Chondroitin Sulfates	0-2	cytochrome c, somatic	Homo sapiens	212-217
28990084-9	2017	CS also significantly attenuated WT and A53T mutant alpha-SYN-induced dysfunction, including decrease of mitochondrial membrane potential, decrease of Bcl-2 expression, and increase of Bax expression, release of Cyt-c from the mitochondria and activation of caspase-3 and caspase-9, which demonstrated that CS suppressed alpha-SYN-induced apoptosis possibly through mitochondria protection.	Chondroitin Sulfates	0-2	caspase 3	Homo sapiens	258-267
28990084-9	2017	CS also significantly attenuated WT and A53T mutant alpha-SYN-induced dysfunction, including decrease of mitochondrial membrane potential, decrease of Bcl-2 expression, and increase of Bax expression, release of Cyt-c from the mitochondria and activation of caspase-3 and caspase-9, which demonstrated that CS suppressed alpha-SYN-induced apoptosis possibly through mitochondria protection.	Chondroitin Sulfates	0-2	caspase 9	Homo sapiens	272-281
28990084-9	2017	CS also significantly attenuated WT and A53T mutant alpha-SYN-induced dysfunction, including decrease of mitochondrial membrane potential, decrease of Bcl-2 expression, and increase of Bax expression, release of Cyt-c from the mitochondria and activation of caspase-3 and caspase-9, which demonstrated that CS suppressed alpha-SYN-induced apoptosis possibly through mitochondria protection.	Chondroitin Sulfates	0-2	synuclein alpha	Homo sapiens	321-330
28990084-10	2017	These results suggested that CS protects SH-SY5Y cells overexpressing WT or A53T mutant alpha-SYN by inhibiting the expression and phosphorylation of alpha-SYN, and ROS overproduction and mitochondrial apoptosis.	Chondroitin Sulfates	29-31	synuclein alpha	Homo sapiens	88-97
28990084-10	2017	These results suggested that CS protects SH-SY5Y cells overexpressing WT or A53T mutant alpha-SYN by inhibiting the expression and phosphorylation of alpha-SYN, and ROS overproduction and mitochondrial apoptosis.	Chondroitin Sulfates	29-31	synuclein alpha	Homo sapiens	150-159
29290949-1	2017	Neurocan (NCAN), a secreted chondroitin sulfate proteoglycan, is one of the major inhibitory molecules for axon regeneration in nervous injury.	Chondroitin Sulfates	28-47	neurocan	Mus musculus	0-8
29290949-1	2017	Neurocan (NCAN), a secreted chondroitin sulfate proteoglycan, is one of the major inhibitory molecules for axon regeneration in nervous injury.	Chondroitin Sulfates	28-47	neurocan	Mus musculus	10-14
29310782-1	2018	Versican is a chondroitin sulfate proteoglycan found in the extracellular matrix that is important for changes in cell phenotype associated with development and disease.	Chondroitin Sulfates	14-33	versican	Homo sapiens	0-8
29287114-4	2017	Previous studies have suggested that two glycosyltransferases, Csgalnact1 (t1) and Csgalnact2 (t2), are critical for initiation of CS synthesis in vitro.	Chondroitin Sulfates	131-133	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	63-73
29287114-4	2017	Previous studies have suggested that two glycosyltransferases, Csgalnact1 (t1) and Csgalnact2 (t2), are critical for initiation of CS synthesis in vitro.	Chondroitin Sulfates	131-133	chondroitin sulfate N-acetylgalactosaminyltransferase 2	Mus musculus	83-93
28890301-3	2017	The inhibitory properties of the CSPGs depend on the pattern of sulfation of their glycosaminoglycans, with chondroitin 4-sulfate (C4S) being the most inhibitory form.	Chondroitin Sulfates	131-134	carbohydrate sulfotransferase 11	Mus musculus	108-121
29093576-4	2017	Using this methodology, the saccharide sequence of the chondroitin sulfate chain of the proteoglycan bikunin was determined.	Chondroitin Sulfates	55-74	alpha-1-microglobulin/bikunin precursor	Homo sapiens	101-108
29085061-3	2017	We found that cell surface binding and internalization of 3D8 scFv were inhibited markedly in soluble heparan sulfate (HS)/chondroitin sulfate (CS)-deficient or -removed cells and in the presence of soluble HS and CS.	Chondroitin Sulfates	123-142	immunglobulin heavy chain variable region	Homo sapiens	62-66
29085061-3	2017	We found that cell surface binding and internalization of 3D8 scFv were inhibited markedly in soluble heparan sulfate (HS)/chondroitin sulfate (CS)-deficient or -removed cells and in the presence of soluble HS and CS.	Chondroitin Sulfates	144-146	immunglobulin heavy chain variable region	Homo sapiens	62-66
29085061-3	2017	We found that cell surface binding and internalization of 3D8 scFv were inhibited markedly in soluble heparan sulfate (HS)/chondroitin sulfate (CS)-deficient or -removed cells and in the presence of soluble HS and CS.	Chondroitin Sulfates	214-216	immunglobulin heavy chain variable region	Homo sapiens	62-66
29245974-1	2017	The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate.	Chondroitin Sulfates	176-197	arylsulfatase B	Homo sapiens	62-66
29245974-1	2017	The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate.	Chondroitin Sulfates	176-197	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	72-106
29245974-1	2017	The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate.	Chondroitin Sulfates	176-197	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	108-113
29245974-1	2017	The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate.	Chondroitin Sulfates	199-202	arylsulfatase B	Homo sapiens	62-66
29245974-1	2017	The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate.	Chondroitin Sulfates	199-202	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	72-106
29245974-1	2017	The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate.	Chondroitin Sulfates	199-202	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	108-113
29245974-1	2017	The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate.	Chondroitin Sulfates	252-273	arylsulfatase B	Homo sapiens	62-66
29245974-1	2017	The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate.	Chondroitin Sulfates	252-273	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	72-106
29245974-1	2017	The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate.	Chondroitin Sulfates	252-273	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	108-113
29245974-1	2017	The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate.	Chondroitin Sulfates	302-321	arylsulfatase B	Homo sapiens	62-66
29245974-1	2017	The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate.	Chondroitin Sulfates	302-321	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	72-106
29245974-1	2017	The chondroitin sulfatases N-acetylgalactosamine-4-sulfatase (ARSB) and galactosamine-N-acetyl-6-sulfatase (GALNS) remove either the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and dermatan sulfate, or the 6-sulfate group of chondroitin 6-sulfate, chondroitin 4,6-disulfate (chondroitin sulfate E), or keratan sulfate.	Chondroitin Sulfates	302-321	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	108-113
29067569-2	2017	MTX-CS NGs can greatly enhance the solubility and improve the delivery efficacy of MTX due to the CD44 binding property of CS.	Chondroitin Sulfates	4-6	CD44 molecule (Indian blood group)	Homo sapiens	98-102
29067569-5	2017	Due to their CD44 binding property, chondroitin sulfate-drug conjugates could be a promising and efficient platform for improving the solubility of sparingly soluble drug molecules as well as targeted delivery to cancer cells and tumor tissues.	Chondroitin Sulfates	36-55	CD44 molecule (Indian blood group)	Homo sapiens	13-17
28974755-4	2017	Here, we show that initiation of ocular dominance plasticity was impaired with reduced CS, using mice lacking a key CS-synthesizing enzyme, CSGalNAcT1.	Chondroitin Sulfates	116-118	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	140-150
28890259-9	2017	We found that silk-CS scaffold maintained better chondrocyte phenotype than silk scaffold; moreover, the silk-CS scaffolds reduced chondrocyte inflammatory response that was induced by interleukin (IL)-1beta, which is in consistent with the well-documented anti-inflammatory activities of CS.	Chondroitin Sulfates	19-21	interleukin 1 beta	Homo sapiens	185-207
28890259-9	2017	We found that silk-CS scaffold maintained better chondrocyte phenotype than silk scaffold; moreover, the silk-CS scaffolds reduced chondrocyte inflammatory response that was induced by interleukin (IL)-1beta, which is in consistent with the well-documented anti-inflammatory activities of CS.	Chondroitin Sulfates	110-112	interleukin 1 beta	Homo sapiens	185-207
28890259-9	2017	We found that silk-CS scaffold maintained better chondrocyte phenotype than silk scaffold; moreover, the silk-CS scaffolds reduced chondrocyte inflammatory response that was induced by interleukin (IL)-1beta, which is in consistent with the well-documented anti-inflammatory activities of CS.	Chondroitin Sulfates	110-112	interleukin 1 beta	Homo sapiens	185-207
28982363-0	2017	Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis.	Chondroitin Sulfates	92-111	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	64-74
28982363-3	2017	To investigate the importance of CS, we produced and precisely examined mice that were deficient in the CS synthesizing enzyme, CSGalNAcT1 (T1KO).	Chondroitin Sulfates	104-106	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	128-138
28652022-2	2017	Here, we report that chondroitin sulfate synthase 1 (CHSY1), the enzyme that mediates the polymerization step of chondroitin sulfate, is a critical mediator of malignant character in HCC that acts via modulating the activity of the hedgehog signaling.	Chondroitin Sulfates	21-40	chondroitin sulfate synthase 1	Homo sapiens	53-58
28536017-9	2017	In contrast, on bone marrow derived macrophages, C4S, C6S, BT and PT-CS reduced the LPS-induced liberation of TNF-alpha, IL-6, IL-1beta and NO, indicating that the RAW response to CS was different from that of primary macrophages.	Chondroitin Sulfates	69-71	interleukin 1 beta	Homo sapiens	127-135
28849661-0	2017	Synthesis of Chondroitin Sulfate A Bearing Syndecan-1 Glycopeptide.	Chondroitin Sulfates	13-34	syndecan 1	Homo sapiens	43-53
28652022-5	2017	Mechanistic investigations revealed that the increase of cell surface chondroitin sulfate by CHSY1 promoted sonic hedgehog binding and signaling.	Chondroitin Sulfates	70-89	chondroitin sulfate synthase 1	Homo sapiens	93-98
28652022-7	2017	Together, our results indicate that CHSY1 overexpression in HCC contributes to the malignant behaviors in cancer cells, we provide novel insights into the significance of chondroitin sulfate in hedgehog signaling and HCC pathogenesis.	Chondroitin Sulfates	171-190	chondroitin sulfate synthase 1	Homo sapiens	36-41
28245911-8	2017	Changes in RANTES and UCN synovial fluid concentration were associated with CS treatment.	Chondroitin Sulfates	76-78	C-C motif chemokine ligand 5	Homo sapiens	11-17
28904929-2	2017	The loss of GALNS activity leads to the impaired breakdown of glycosaminoglycans (GAGs) keratan sulfate and chondroitin-6-sulfate.	Chondroitin Sulfates	108-129	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	12-17
28170164-1	2017	Perineuronal nets (PNN) are aggregations of chondroitin sulfate proteoglycans surrounding the soma and proximal processes of neurons, mostly GABAergic interneurons expressing parvalbumin.	Chondroitin Sulfates	44-63	pinin	Sturnus vulgaris	19-22
29088739-0	2017	Chondroitin sulfate proteoglycan serglycin influences protein cargo loading and functions of tumor-derived exosomes.	Chondroitin Sulfates	0-19	serglycin	Homo sapiens	33-42
28771551-8	2017	Molecular dynamics simulations show that the conformation of cathepsin K is influenced by known allosteric effectors, chondroitin sulfate and the small molecules NSC13345 and NSC94914.	Chondroitin Sulfates	118-137	cathepsin K	Homo sapiens	61-72
28810613-5	2017	Safranin O staining revealed that the expression of chondroitin sulfate was significantly increased in the group of miR-127-5p, than the miRNA control group.	Chondroitin Sulfates	52-71	microRNA 127	Rattus norvegicus	116-123
28684419-2	2017	Versican is a large chondroitin sulfate-containing, hyaluronic acid-binding proteoglycan present in the extracellular matrix and in ocular vitreous body.	Chondroitin Sulfates	20-39	versican	Homo sapiens	0-8
28890654-0	2017	Chondroitin Sulfate Inhibits Monocyte Chemoattractant Protein-1 Release From 3T3-L1 Adipocytes: A New Treatment Opportunity for Obesity-Related Inflammation?	Chondroitin Sulfates	0-19	C-C motif chemokine ligand 2	Homo sapiens	29-63
28890654-4	2017	At the same time, varying concentrations of chondroitin sulfate (CS) were added in a physiologically relevant range (10-200 microg/mL) to determine its impact on MCP-1 release.	Chondroitin Sulfates	44-63	C-C motif chemokine ligand 2	Homo sapiens	162-167
28890654-4	2017	At the same time, varying concentrations of chondroitin sulfate (CS) were added in a physiologically relevant range (10-200 microg/mL) to determine its impact on MCP-1 release.	Chondroitin Sulfates	65-67	C-C motif chemokine ligand 2	Homo sapiens	162-167
28890654-6	2017	Because the main action of MCP-1 is to induce monocyte migration, cultured THP-1 monocytes were used to test whether CS at the highest physiologically relevant concentration could inhibit cell migration induced by human recombinant MCP-1.	Chondroitin Sulfates	117-119	C-C motif chemokine ligand 2	Homo sapiens	232-237
28890654-7	2017	Chondroitin sulfate (100-200 microg/mL) inhibited MCP-1 release from inflamed adipocytes in a dose-dependent manner (P &lt; .01, 95% confidence interval [CI]: -5.89 to -3.858 at 100 microg/mL and P &lt; .001, 95% CI: -6.028 to -3.996 at 200 microg/mL) but had no effect on MCP-1-driven chemotaxis of THP-1 monocytes.	Chondroitin Sulfates	0-19	C-C motif chemokine ligand 2	Homo sapiens	50-55
28890654-7	2017	Chondroitin sulfate (100-200 microg/mL) inhibited MCP-1 release from inflamed adipocytes in a dose-dependent manner (P &lt; .01, 95% confidence interval [CI]: -5.89 to -3.858 at 100 microg/mL and P &lt; .001, 95% CI: -6.028 to -3.996 at 200 microg/mL) but had no effect on MCP-1-driven chemotaxis of THP-1 monocytes.	Chondroitin Sulfates	0-19	C-C motif chemokine ligand 2	Homo sapiens	273-278
28890654-7	2017	Chondroitin sulfate (100-200 microg/mL) inhibited MCP-1 release from inflamed adipocytes in a dose-dependent manner (P &lt; .01, 95% confidence interval [CI]: -5.89 to -3.858 at 100 microg/mL and P &lt; .001, 95% CI: -6.028 to -3.996 at 200 microg/mL) but had no effect on MCP-1-driven chemotaxis of THP-1 monocytes.	Chondroitin Sulfates	0-19	GLI family zinc finger 2	Homo sapiens	300-305
28890654-8	2017	In summary, CS could be expected to reduce macrophage infiltration into adipose tissue by reduction in adipocyte expression and release of MCP-1 and as such might reduce adipose tissue inflammation in response to pro-inflammatory stimuli such as LPS, now increasingly recognized to be relevant in vivo.	Chondroitin Sulfates	12-14	C-C motif chemokine ligand 2	Homo sapiens	139-144
28454729-6	2017	Fibroblasts differentiated to adipocytes and treated with TIP39 also showed increased decorin and production of chondroitin sulfate.	Chondroitin Sulfates	112-131	parathyroid hormone 2	Mus musculus	58-63
28586015-4	2017	The results indicated that Met, UC-II, CS, MSM and AO slightly or moderately suppressed the IL-1beta-stimulated IL-8 production by human synovial MH7A cells.	Chondroitin Sulfates	39-41	interleukin 1 beta	Homo sapiens	92-100
28586015-4	2017	The results indicated that Met, UC-II, CS, MSM and AO slightly or moderately suppressed the IL-1beta-stimulated IL-8 production by human synovial MH7A cells.	Chondroitin Sulfates	39-41	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
28514734-4	2017	Since chondroitin sulfate synthesis is controlled by chondroitin sulfate glycosyltransferases CHSY-1/2/3 and CSGALNACT-1/2, their functional role and regulatory mechanism in IDD is not fully studied.	Chondroitin Sulfates	6-25	chondroitin sulfate synthase 1	Homo sapiens	94-104
28514734-4	2017	Since chondroitin sulfate synthesis is controlled by chondroitin sulfate glycosyltransferases CHSY-1/2/3 and CSGALNACT-1/2, their functional role and regulatory mechanism in IDD is not fully studied.	Chondroitin Sulfates	6-25	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	109-122
28514734-8	2017	By computational prediction and analysis, we found that inflammatory cytokines stimulated microRNA-194 and -515 target CHSY-1/2/3 mRNA and significantly interrupt their translation and downstream chondroitin sulfate deposition.	Chondroitin Sulfates	196-215	chondroitin sulfate synthase 1	Homo sapiens	119-129
28245911-8	2017	Changes in RANTES and UCN synovial fluid concentration were associated with CS treatment.	Chondroitin Sulfates	76-78	urocortin	Homo sapiens	22-25
28245911-11	2017	The CS anti-inflammatory effect could be related to the observed changes in RANTES and UCN concentration.	Chondroitin Sulfates	4-6	C-C motif chemokine ligand 5	Homo sapiens	76-82
28245911-11	2017	The CS anti-inflammatory effect could be related to the observed changes in RANTES and UCN concentration.	Chondroitin Sulfates	4-6	urocortin	Homo sapiens	87-90
28535934-4	2017	Since GlcN is present only in KS we developed a method that separates GlcN from GalN, the principal hydrolytic product of CS, and then we validated it in order to quantify GlcN.	Chondroitin Sulfates	122-124	galanin and GMAP prepropeptide	Homo sapiens	80-84
28420813-6	2017	Both PGA and OX40L+HK were indispensable for HKOX3-PGA growth, but HKOX3-CDR could proliferate in the presence of CDR or OX40L+HK alone.	Chondroitin Sulfates	73-76	TNF superfamily member 4	Homo sapiens	121-129
28333845-4	2017	METHODS: The expression of highly sulfated chondroitin sulfate (CS-E), a characteristic glycosaminoglycan of the cancer-associated ECM, was assessed by immunohistochemistry in a large cohort of precursor lesions of the full spectrum of HGSC development, including 97 serous tubal intraepithelial carcinomas (STICs), 27 serous tubal intraepithelial lesions, and 24 p53 signatures.	Chondroitin Sulfates	43-62	tumor protein p53	Homo sapiens	364-367
28728606-10	2017	In patients with levels of biomarkers of inflammation (HA, leptin and adipsin) lower than the median, those treated with chondroitin sulfate demonstrated less cartilage volume loss in the medial compartment, condyle, and plateau (p &lt;= 0.047).	Chondroitin Sulfates	121-140	leptin	Homo sapiens	59-65
28728606-10	2017	In patients with levels of biomarkers of inflammation (HA, leptin and adipsin) lower than the median, those treated with chondroitin sulfate demonstrated less cartilage volume loss in the medial compartment, condyle, and plateau (p &lt;= 0.047).	Chondroitin Sulfates	121-140	complement factor D	Homo sapiens	70-77
28728606-11	2017	In contrast, patients treated with chondroitin sulfate with higher levels of MMP-1 and MMP-3, biomarkers of cartilage catabolism, had less cartilage volume loss in the medial compartment, condyle, and plateau (p &lt;= 0.050).	Chondroitin Sulfates	35-54	matrix metallopeptidase 1	Homo sapiens	77-82
28728606-11	2017	In contrast, patients treated with chondroitin sulfate with higher levels of MMP-1 and MMP-3, biomarkers of cartilage catabolism, had less cartilage volume loss in the medial compartment, condyle, and plateau (p &lt;= 0.050).	Chondroitin Sulfates	35-54	matrix metallopeptidase 3	Homo sapiens	87-92
28498493-5	2017	The amount of Brn3a(+) RGC significantly decreased in CS-injected eyes for 10 and 15 (but not 6) weeks.	Chondroitin Sulfates	54-56	POU class 4 homeobox 1	Rattus norvegicus	14-19
28333845-4	2017	METHODS: The expression of highly sulfated chondroitin sulfate (CS-E), a characteristic glycosaminoglycan of the cancer-associated ECM, was assessed by immunohistochemistry in a large cohort of precursor lesions of the full spectrum of HGSC development, including 97 serous tubal intraepithelial carcinomas (STICs), 27 serous tubal intraepithelial lesions, and 24 p53 signatures.	Chondroitin Sulfates	64-68	tumor protein p53	Homo sapiens	364-367
28247915-4	2017	The TRIS-silica surface was further coated with a layer of chondroitin sulfate A (CSA) yielding the doubly layered hydrophilic CSA-TRIS-silica column.	Chondroitin Sulfates	59-80	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	82-85
28511876-0	2017	Chondroitin sulfate-functionalized polyamidoamine as a tumor-targeted carrier for miR-34a delivery.	Chondroitin Sulfates	0-19	microRNA 34a	Mus musculus	82-89
28511876-1	2017	Chondroitin sulfate (CS) was modified on a polyamidoamine dendrimer (PAMAM) through Michael addition to construct a tumor-targeted carrier CS-PAMAM for miR-34a delivery.	Chondroitin Sulfates	0-19	microRNA 34a	Mus musculus	152-159
28511876-1	2017	Chondroitin sulfate (CS) was modified on a polyamidoamine dendrimer (PAMAM) through Michael addition to construct a tumor-targeted carrier CS-PAMAM for miR-34a delivery.	Chondroitin Sulfates	21-23	microRNA 34a	Mus musculus	152-159
28511876-6	2017	STATEMENT OF SIGNIFICANCE: The cationic dendrimer PAMAM was modified by chondroitin sulfate (CS) through Michael addition to construct a tumor-targeted carrier CS-PAMAM for miR-34a delivery.	Chondroitin Sulfates	72-91	microRNA 34a	Mus musculus	173-180
28511876-6	2017	STATEMENT OF SIGNIFICANCE: The cationic dendrimer PAMAM was modified by chondroitin sulfate (CS) through Michael addition to construct a tumor-targeted carrier CS-PAMAM for miR-34a delivery.	Chondroitin Sulfates	93-95	microRNA 34a	Mus musculus	173-180
28511876-7	2017	The introduction of CS could achieve an efficient cellular uptake and intracellular transfection of miR-34a in a CD44-dependent endocytosis manner.	Chondroitin Sulfates	20-22	microRNA 34a	Mus musculus	100-107
28511876-7	2017	The introduction of CS could achieve an efficient cellular uptake and intracellular transfection of miR-34a in a CD44-dependent endocytosis manner.	Chondroitin Sulfates	20-22	CD44 antigen	Mus musculus	113-117
28511876-9	2017	The CS-PAMAM-mediated systemic delivery of miR-34a showed significant inhibition of tumor growth and induction of tumor apoptosis using a mice model of subcutaneously implanted tumors.	Chondroitin Sulfates	4-6	microRNA 34a	Mus musculus	43-50
28247915-4	2017	The TRIS-silica surface was further coated with a layer of chondroitin sulfate A (CSA) yielding the doubly layered hydrophilic CSA-TRIS-silica column.	Chondroitin Sulfates	59-80	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	127-130
28569157-0	2017	Effects of sesamin on chondroitin sulfate proteoglycan synthesis induced by interleukin-1beta in human chondrocytes.	Chondroitin Sulfates	22-41	interleukin 1 beta	Homo sapiens	76-93
28558026-4	2017	Using this system, we demonstrate that heparin, an analog of heparan sulfate, induced the dimerization of RPTPsigma, whereas chondroitin sulfate increased RPTPsigma activity by inhibiting RPTPsigma dimerization.	Chondroitin Sulfates	125-144	protein tyrosine phosphatase receptor type S	Homo sapiens	155-164
28558026-4	2017	Using this system, we demonstrate that heparin, an analog of heparan sulfate, induced the dimerization of RPTPsigma, whereas chondroitin sulfate increased RPTPsigma activity by inhibiting RPTPsigma dimerization.	Chondroitin Sulfates	125-144	protein tyrosine phosphatase receptor type S	Homo sapiens	155-164
28325347-1	2017	Two fucosylated chondroitin sulfates EF1 and EF2 were isolated from the sea cucumber Eupentacta fraudatrix.	Chondroitin Sulfates	16-36	elongation factor 1-alpha	Cucumis sativus	37-40
28325347-4	2017	The backbone of EF1 was found to be composed of chondroitin sulfate A and E units in a ratio of about 1:1.	Chondroitin Sulfates	48-69	elongation factor 1-alpha	Cucumis sativus	16-19
28539925-6	2017	Compared to CXCL9(74-103), CXCL9(74-93) showed equally high affinity for heparin and heparan sulfate (HS), but lower affinity for binding to chondroitin sulfate (CS) and cellular GAGs.	Chondroitin Sulfates	141-160	chemokine (C-X-C motif) ligand 9	Mus musculus	27-32
28539925-6	2017	Compared to CXCL9(74-103), CXCL9(74-93) showed equally high affinity for heparin and heparan sulfate (HS), but lower affinity for binding to chondroitin sulfate (CS) and cellular GAGs.	Chondroitin Sulfates	162-164	chemokine (C-X-C motif) ligand 9	Mus musculus	27-32
28539925-11	2017	This could be explained by (1) the lower affinity of CXCL9(74-93) for CS, the most abundant GAG in joints, and (2) by reduced competition with GAG binding of CXCL1, the most abundant ELR+ CXC chemokine in this gout model.	Chondroitin Sulfates	70-72	chemokine (C-X-C motif) ligand 9	Mus musculus	53-58
28209294-7	2017	RESULTS: A highly sulfated chondroitin sulfate (CS-E) or its substitute (heparinoid) had marked inhibitory effects on TGF-beta-mediated changes in HSF behaviors.	Chondroitin Sulfates	27-46	transforming growth factor beta 1	Homo sapiens	118-126
28209294-10	2017	CONCLUSIONS: TGF-beta, bFGF and epimorphin in the extracellular microenvironment cooperatively affect HSF behaviors under the control of a highly sulfated chondroitin sulfate.	Chondroitin Sulfates	155-174	transforming growth factor beta 1	Homo sapiens	13-21
28209294-10	2017	CONCLUSIONS: TGF-beta, bFGF and epimorphin in the extracellular microenvironment cooperatively affect HSF behaviors under the control of a highly sulfated chondroitin sulfate.	Chondroitin Sulfates	155-174	fibroblast growth factor 2	Homo sapiens	23-27
28209294-10	2017	CONCLUSIONS: TGF-beta, bFGF and epimorphin in the extracellular microenvironment cooperatively affect HSF behaviors under the control of a highly sulfated chondroitin sulfate.	Chondroitin Sulfates	155-174	syntaxin 2	Homo sapiens	32-42
28616017-4	2017	Studies in vitro show that in the presence of soluble HB-GAM chondroitin sulfate (CS) chains of CSPGs display an enhancing effect on neurite outgrowth.	Chondroitin Sulfates	61-80	pleiotrophin	Homo sapiens	54-60
28616017-4	2017	Studies in vitro show that in the presence of soluble HB-GAM chondroitin sulfate (CS) chains of CSPGs display an enhancing effect on neurite outgrowth.	Chondroitin Sulfates	82-84	pleiotrophin	Homo sapiens	54-60
28616017-5	2017	Based on the in vitro studies, we suggest a model according to which the HB-GAM/CS complex binds to the neuron surface receptor glypican-2, which induces neurite growth.	Chondroitin Sulfates	80-82	pleiotrophin	Homo sapiens	73-79
28616017-5	2017	Based on the in vitro studies, we suggest a model according to which the HB-GAM/CS complex binds to the neuron surface receptor glypican-2, which induces neurite growth.	Chondroitin Sulfates	80-82	glypican 2	Homo sapiens	128-138
28616017-6	2017	Furthermore, HB-GAM masks the CS binding sites of the neurite outgrowth inhibiting receptor protein tyrosine phosphatase sigma (PTPsigma), which may contribute to the HB-GAM-induced regenerative effect.	Chondroitin Sulfates	30-32	pleiotrophin	Homo sapiens	13-19
28616017-6	2017	Furthermore, HB-GAM masks the CS binding sites of the neurite outgrowth inhibiting receptor protein tyrosine phosphatase sigma (PTPsigma), which may contribute to the HB-GAM-induced regenerative effect.	Chondroitin Sulfates	30-32	protein tyrosine phosphatase receptor type S	Homo sapiens	128-136
28616017-6	2017	Furthermore, HB-GAM masks the CS binding sites of the neurite outgrowth inhibiting receptor protein tyrosine phosphatase sigma (PTPsigma), which may contribute to the HB-GAM-induced regenerative effect.	Chondroitin Sulfates	30-32	pleiotrophin	Homo sapiens	167-173
28616017-9	2017	Studies on the HB-GAM/CS mechanism in vitro and in vivo are expected to pave the way for drug development for injuries of brain and spinal cord.	Chondroitin Sulfates	22-24	pleiotrophin	Homo sapiens	15-21
28920399-1	2017	In order to promote the growth of chondrocyte ATDC-5 in collagen type II-hyaluronic acid-chondroitin sulfate composite scaffolds constructed previously in vitro, the sustained-releasing chitosan microspheres loading TGF-beta1 were prepared by emulsification and cross-linking.	Chondroitin Sulfates	89-108	tripartite motif containing 29	Homo sapiens	46-50
28209711-7	2017	Binding of Hic to hTSP-1 is inhibited by heparin and chondroitin sulfate A, indicating binding to the N-terminal globular domain or type I repeats of hTSP-1.	Chondroitin Sulfates	53-74	MyoD family inhibitor domain containing	Homo sapiens	11-14
28209711-7	2017	Binding of Hic to hTSP-1 is inhibited by heparin and chondroitin sulfate A, indicating binding to the N-terminal globular domain or type I repeats of hTSP-1.	Chondroitin Sulfates	53-74	thrombospondin 1	Homo sapiens	18-24
28209294-7	2017	RESULTS: A highly sulfated chondroitin sulfate (CS-E) or its substitute (heparinoid) had marked inhibitory effects on TGF-beta-mediated changes in HSF behaviors.	Chondroitin Sulfates	48-52	transforming growth factor beta 1	Homo sapiens	118-126
28159857-3	2017	These 8 enzymes are under direct control of the androgen receptor (AR) and are linked to the synthesis of important cancer-associated glycans such as sialyl-Tn (sTn), sialyl LewisX (SLeX), O-GlcNAc and chondroitin sulfate.	Chondroitin Sulfates	202-221	androgen receptor	Homo sapiens	48-65
27878326-10	2017	Finally, the 72-kDa chondroitin sulfate is the result of O-linked glycosylation of the 32-kDa protein core of OGN.	Chondroitin Sulfates	20-39	osteoglycin	Mus musculus	110-113
27878326-12	2017	CONCLUSION: The current study discovered a novel 72-kDa chondroitin sulfate-OGN that is specific for innate immune cells.	Chondroitin Sulfates	56-75	osteoglycin	Mus musculus	76-79
28159857-3	2017	These 8 enzymes are under direct control of the androgen receptor (AR) and are linked to the synthesis of important cancer-associated glycans such as sialyl-Tn (sTn), sialyl LewisX (SLeX), O-GlcNAc and chondroitin sulfate.	Chondroitin Sulfates	202-221	androgen receptor	Homo sapiens	67-69
27484097-1	2017	BACKGROUND AND AIMS: Carbohydrate sulphotransferase 15 [CHST15] is a specific enzyme biosynthesizing chondroitin sulphate E that binds various pathogenic mediators and is known to create local fibrotic lesions.	Chondroitin Sulfates	101-121	carbohydrate sulfotransferase 15	Homo sapiens	21-54
27484097-1	2017	BACKGROUND AND AIMS: Carbohydrate sulphotransferase 15 [CHST15] is a specific enzyme biosynthesizing chondroitin sulphate E that binds various pathogenic mediators and is known to create local fibrotic lesions.	Chondroitin Sulfates	101-121	carbohydrate sulfotransferase 15	Homo sapiens	56-62
27641734-2	2017	CD97 (EGF1-5) is a splicing variant of CD97 that recognizes a specific ligand chondroitin sulfate on cell membranes and the extracellular matrix.	Chondroitin Sulfates	78-97	adhesion G protein-coupled receptor E5	Homo sapiens	0-4
27926479-6	2017	Since the only known function of ARSB is to remove 4-sulfate groups from the N-acetylgalactosamine 4-sulfate residue at the non-reducing end of chondroitin 4-sulfate (C4S) or dermatan sulfate, experiments were performed to determine the transcriptional mechanisms by which expression of CSPG4 and MMP2 increased.	Chondroitin Sulfates	144-165	arylsulfatase B	Homo sapiens	33-37
27926479-6	2017	Since the only known function of ARSB is to remove 4-sulfate groups from the N-acetylgalactosamine 4-sulfate residue at the non-reducing end of chondroitin 4-sulfate (C4S) or dermatan sulfate, experiments were performed to determine the transcriptional mechanisms by which expression of CSPG4 and MMP2 increased.	Chondroitin Sulfates	167-170	arylsulfatase B	Homo sapiens	33-37
27641734-2	2017	CD97 (EGF1-5) is a splicing variant of CD97 that recognizes a specific ligand chondroitin sulfate on cell membranes and the extracellular matrix.	Chondroitin Sulfates	78-97	G elongation factor mitochondrial 1	Homo sapiens	6-12
27641734-2	2017	CD97 (EGF1-5) is a splicing variant of CD97 that recognizes a specific ligand chondroitin sulfate on cell membranes and the extracellular matrix.	Chondroitin Sulfates	78-97	adhesion G protein-coupled receptor E5	Homo sapiens	39-43
27753269-3	2017	CHST3 gene encodes the enzyme chondroitin 6-O-sulfotransferase-1 (C6ST-1) which mediates the sulfation of proteoglycans, (chondroitin sulfate), in the extracellular matrix of cartilage.	Chondroitin Sulfates	122-141	carbohydrate sulfotransferase 3	Homo sapiens	0-5
27753269-3	2017	CHST3 gene encodes the enzyme chondroitin 6-O-sulfotransferase-1 (C6ST-1) which mediates the sulfation of proteoglycans, (chondroitin sulfate), in the extracellular matrix of cartilage.	Chondroitin Sulfates	122-141	carbohydrate sulfotransferase 3	Homo sapiens	30-64
27753269-3	2017	CHST3 gene encodes the enzyme chondroitin 6-O-sulfotransferase-1 (C6ST-1) which mediates the sulfation of proteoglycans, (chondroitin sulfate), in the extracellular matrix of cartilage.	Chondroitin Sulfates	122-141	carbohydrate sulfotransferase 3	Homo sapiens	66-72
28867754-1	2017	Sushi repeat-containing protein X-linked 2 (SRPX2) is a newly identified chondroitin sulfate proteoglycan that is markedly elevated in multiple solid tumors.	Chondroitin Sulfates	73-92	sushi repeat containing protein X-linked 2	Homo sapiens	0-42
28867754-1	2017	Sushi repeat-containing protein X-linked 2 (SRPX2) is a newly identified chondroitin sulfate proteoglycan that is markedly elevated in multiple solid tumors.	Chondroitin Sulfates	73-92	sushi repeat containing protein X-linked 2	Homo sapiens	44-49
27599773-3	2017	CSGALNACT1 encodes chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1, ChGn-1), which initiates chondroitin sulfate (CS) chain biosynthesis on the so-called GAG-protein linker region tetrasaccharide.	Chondroitin Sulfates	19-38	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	0-10
27599773-3	2017	CSGALNACT1 encodes chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1, ChGn-1), which initiates chondroitin sulfate (CS) chain biosynthesis on the so-called GAG-protein linker region tetrasaccharide.	Chondroitin Sulfates	19-38	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	76-87
27599773-3	2017	CSGALNACT1 encodes chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1, ChGn-1), which initiates chondroitin sulfate (CS) chain biosynthesis on the so-called GAG-protein linker region tetrasaccharide.	Chondroitin Sulfates	114-133	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	0-10
27599773-3	2017	CSGALNACT1 encodes chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1, ChGn-1), which initiates chondroitin sulfate (CS) chain biosynthesis on the so-called GAG-protein linker region tetrasaccharide.	Chondroitin Sulfates	114-133	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	76-87
27599773-3	2017	CSGALNACT1 encodes chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1, ChGn-1), which initiates chondroitin sulfate (CS) chain biosynthesis on the so-called GAG-protein linker region tetrasaccharide.	Chondroitin Sulfates	0-2	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	76-87
27655130-6	2016	Saturating concentrations of rVAR2 inhibited downstream integrin signaling, which was mimicked by knockdown of the core chondroitin sulfate synthesis enzymes beta-1,3-glucuronyltransferase 1 (B3GAT1) and chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1).	Chondroitin Sulfates	120-139	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	Mus musculus	192-198
27746349-6	2016	Our vectors deliver C3 in a cell-autonomous (endogenous) or a cell-nonautonomous (secretable/permeable) fashion and promote in vitro process outgrowth on inhibitory chondroitin sulfate proteoglycan substrate.	Chondroitin Sulfates	165-184	complement C3	Homo sapiens	20-22
27614315-2	2017	DESIGN: THP-1 macrophages were cultured with a range of sizes and concentrations of HA fragments with TLR4 (LPS in a physiologically relevant concentration determined by analyses of sera of a community clinic ascertained knee osteoarthritis (OA) cohort) or TLR2 (heat killed listeria bacteria) agonists and varying concentrations of CS in a physiologically relevant range (10-200 mug/ml).	Chondroitin Sulfates	333-335	GLI family zinc finger 2	Homo sapiens	8-13
27614315-7	2017	However, primed with LPS, HA fragments produced large dose-dependent increases in IL-1beta that were inhibitable by CS.	Chondroitin Sulfates	116-118	interleukin 1 beta	Homo sapiens	82-90
27614315-8	2017	CS did not inhibit caspase-1 activity but in physiologically achievable concentrations, attenuated NF-kappaB activity induced by either the TLR4 (LPS 1000 ng/ml) or TLR2 agonists alone or in combination with HA fragments.	Chondroitin Sulfates	0-2	toll like receptor 4	Homo sapiens	140-144
27614315-8	2017	CS did not inhibit caspase-1 activity but in physiologically achievable concentrations, attenuated NF-kappaB activity induced by either the TLR4 (LPS 1000 ng/ml) or TLR2 agonists alone or in combination with HA fragments.	Chondroitin Sulfates	0-2	toll like receptor 2	Homo sapiens	165-169
27614315-9	2017	LPS induced and CS significantly reduced activity of canonical NF-kappaB transcription factors, p65, p50, c-Rel and RelB.	Chondroitin Sulfates	16-18	RELA proto-oncogene, NF-kB subunit	Homo sapiens	96-99
27614315-9	2017	LPS induced and CS significantly reduced activity of canonical NF-kappaB transcription factors, p65, p50, c-Rel and RelB.	Chondroitin Sulfates	16-18	nuclear factor kappa B subunit 1	Homo sapiens	101-104
27614315-9	2017	LPS induced and CS significantly reduced activity of canonical NF-kappaB transcription factors, p65, p50, c-Rel and RelB.	Chondroitin Sulfates	16-18	REL proto-oncogene, NF-kB subunit	Homo sapiens	106-111
27614315-9	2017	LPS induced and CS significantly reduced activity of canonical NF-kappaB transcription factors, p65, p50, c-Rel and RelB.	Chondroitin Sulfates	16-18	RELB proto-oncogene, NF-kB subunit	Homo sapiens	116-120
28197173-3	2016	More specifically, neuronal expression of integrin receptors such as alpha9beta1 integrin which binds the extracellular matrix glycoprotein tenascin-C, trk receptors such as trkB which binds the neurotrophic factor BDNF, and receptor PTPsigma which binds chondroitin sulphate proteoglycans, have all been show to significantly enhance regeneration of injured axons.	Chondroitin Sulfates	255-275	neurotrophic receptor tyrosine kinase 2	Homo sapiens	174-178
27495851-3	2016	Here amide hydrogen/deuterium exchange (HDX) mass spectrometry was employed to localize insulin dynamics induced by interactions with three natural polysaccharides, i.e. chitosan (CH), sodium alginate (ALG) and chondroitin sulfate (CS).	Chondroitin Sulfates	211-230	insulin	Homo sapiens	88-95
27495851-3	2016	Here amide hydrogen/deuterium exchange (HDX) mass spectrometry was employed to localize insulin dynamics induced by interactions with three natural polysaccharides, i.e. chitosan (CH), sodium alginate (ALG) and chondroitin sulfate (CS).	Chondroitin Sulfates	232-234	insulin	Homo sapiens	88-95
27495851-9	2016	HDX data evidenced heterogeneous insulin dynamics in the presence of ALG and CS.	Chondroitin Sulfates	77-79	insulin	Homo sapiens	33-40
27751852-5	2016	We previously found that Wnt signaling regulates the sulfation patterns of cell-associated CS chains by suppressing expression of chondroitin 4-O-sulfotaransferase-1 (C4ST-1), a CS biosynthetic enzyme.	Chondroitin Sulfates	91-93	carbohydrate sulfotransferase 11	Homo sapiens	130-165
27751852-5	2016	We previously found that Wnt signaling regulates the sulfation patterns of cell-associated CS chains by suppressing expression of chondroitin 4-O-sulfotaransferase-1 (C4ST-1), a CS biosynthetic enzyme.	Chondroitin Sulfates	91-93	carbohydrate sulfotransferase 11	Homo sapiens	167-173
27751852-5	2016	We previously found that Wnt signaling regulates the sulfation patterns of cell-associated CS chains by suppressing expression of chondroitin 4-O-sulfotaransferase-1 (C4ST-1), a CS biosynthetic enzyme.	Chondroitin Sulfates	178-180	carbohydrate sulfotransferase 11	Homo sapiens	130-165
27751852-5	2016	We previously found that Wnt signaling regulates the sulfation patterns of cell-associated CS chains by suppressing expression of chondroitin 4-O-sulfotaransferase-1 (C4ST-1), a CS biosynthetic enzyme.	Chondroitin Sulfates	178-180	carbohydrate sulfotransferase 11	Homo sapiens	167-173
27498042-3	2016	Type VI collagen (Col VI), an extracellular matrix (ECM) protein found in the periosteum/perichondrium, mediates osteoblast differentiation via the cell-surface receptor neural/glial antigen 2 (NG2) chondroitin sulfate proteoglycan.	Chondroitin Sulfates	199-218	chondroitin sulfate proteoglycan 4	Rattus norvegicus	194-197
28116125-5	2016	MEF2c, ALPL, were upregulated; calcium, decorin and biglycan, and 4C3 and 7D4 chondroitin sulphate sulfation motifs were evident in FGF-18 but not FGF-2 pellets.	Chondroitin Sulfates	78-98	fibroblast growth factor 18	Homo sapiens	132-138
27287227-4	2016	Previous reports have shown that placental-adhering IEs were associated with an unusually low sulfated form of chondroitin sulfate A (CSA) and that a partially sulfated dodecasaccharide is the minimal motif for the interaction.	Chondroitin Sulfates	111-132	chorionic somatomammotropin hormone 1	Homo sapiens	134-137
27645998-5	2016	Loss of C41C4.1 in C. elegans resulted in a decline in 4-O-sulfation of CS and an increase in the number of sulfated units in HS.	Chondroitin Sulfates	72-74	Carbohydrate sulfotransferase chst-1	Caenorhabditis elegans	8-15
27775651-1	2016	Chondroitin sulfate (CS), a type of glycosaminoglycan (GAG), is a factor involved in the suppression of myogenic differentiation.	Chondroitin Sulfates	0-19	heat shock protein 9	Mus musculus	21-23
27755597-3	2016	Here we report that the acid hydrolase HYAL1, a hyaluronidase able to degrade the glycosaminoglycans hyaluronic acid (HA) and chondroitin sulfate, is also upregulated upon osteoclastogenesis.	Chondroitin Sulfates	126-145	hyaluronoglucosaminidase 1	Mus musculus	39-44
27610455-3	2016	Sulfated hyaluronan (sHA) and chondroitin sulfate (sCS) derivatives interfered with TIMP-3/LRP-1 complex formation in a sulfation-dependent manner stronger than heparin.	Chondroitin Sulfates	30-49	TIMP metallopeptidase inhibitor 3	Homo sapiens	84-90
27610455-3	2016	Sulfated hyaluronan (sHA) and chondroitin sulfate (sCS) derivatives interfered with TIMP-3/LRP-1 complex formation in a sulfation-dependent manner stronger than heparin.	Chondroitin Sulfates	30-49	LDL receptor related protein 1	Homo sapiens	91-96
27898729-2	2016	The GAG family includes sulfated heparin, heparan sulfate (HS), dermatan sulfate (DS), chondroitin sulfate (CS), keratan sulfate, and non-sulfated hyaluronan.	Chondroitin Sulfates	87-106	melanoma antigen	Mus musculus	4-7
27898729-2	2016	The GAG family includes sulfated heparin, heparan sulfate (HS), dermatan sulfate (DS), chondroitin sulfate (CS), keratan sulfate, and non-sulfated hyaluronan.	Chondroitin Sulfates	108-110	melanoma antigen	Mus musculus	4-7
27703236-6	2016	Our analyses included wild type C. elegans but also a mutant lacking two HS sulfotransferases (hst-6 hst-2), as we suspected that the altered HS structure could boost CS sulfation.	Chondroitin Sulfates	167-169	Heparan-sulfate 6-O-sulfotransferase	Caenorhabditis elegans	95-100
27671118-2	2016	We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation.	Chondroitin Sulfates	103-105	pleiotrophin	Homo sapiens	20-26
27671118-2	2016	We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation.	Chondroitin Sulfates	103-105	pleiotrophin	Homo sapiens	28-70
27671118-2	2016	We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation.	Chondroitin Sulfates	103-105	pleiotrophin	Homo sapiens	86-98
27671118-2	2016	We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation.	Chondroitin Sulfates	195-197	pleiotrophin	Homo sapiens	20-26
27671118-2	2016	We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation.	Chondroitin Sulfates	195-197	pleiotrophin	Homo sapiens	28-70
27671118-2	2016	We report here that HB-GAM (heparin-binding growth-associated molecule; also known as pleiotrophin), a CS-binding protein expressed at high levels in the developing CNS, reverses the role of the CS chains in neurite growth of CNS neurons in vitro from inhibition to activation.	Chondroitin Sulfates	195-197	pleiotrophin	Homo sapiens	86-98
27671118-3	2016	The CS-bound HB-GAM promotes neurite growth through binding to the cell surface proteoglycan glypican-2; furthermore, HB-GAM abrogates the CS ligand binding to the inhibitory receptor PTPsigma (protein tyrosine phosphatase sigma).	Chondroitin Sulfates	4-6	pleiotrophin	Homo sapiens	13-19
27671118-3	2016	The CS-bound HB-GAM promotes neurite growth through binding to the cell surface proteoglycan glypican-2; furthermore, HB-GAM abrogates the CS ligand binding to the inhibitory receptor PTPsigma (protein tyrosine phosphatase sigma).	Chondroitin Sulfates	4-6	glypican 2	Homo sapiens	93-103
27671118-3	2016	The CS-bound HB-GAM promotes neurite growth through binding to the cell surface proteoglycan glypican-2; furthermore, HB-GAM abrogates the CS ligand binding to the inhibitory receptor PTPsigma (protein tyrosine phosphatase sigma).	Chondroitin Sulfates	4-6	protein tyrosine phosphatase receptor type S	Homo sapiens	184-192
27671118-3	2016	The CS-bound HB-GAM promotes neurite growth through binding to the cell surface proteoglycan glypican-2; furthermore, HB-GAM abrogates the CS ligand binding to the inhibitory receptor PTPsigma (protein tyrosine phosphatase sigma).	Chondroitin Sulfates	4-6	protein tyrosine phosphatase receptor type S	Homo sapiens	194-228
27671118-3	2016	The CS-bound HB-GAM promotes neurite growth through binding to the cell surface proteoglycan glypican-2; furthermore, HB-GAM abrogates the CS ligand binding to the inhibitory receptor PTPsigma (protein tyrosine phosphatase sigma).	Chondroitin Sulfates	139-141	pleiotrophin	Homo sapiens	13-19
27605497-5	2016	ARSB is the enzyme that removes 4-sulfate groups from the non-reducing end of chondroitin 4-sulfate and dermatan sulfate.	Chondroitin Sulfates	78-99	arylsulfatase B	Homo sapiens	0-4
27515218-0	2016	Is chondroitin sulfate responsible for the biological effects attributed to the GC protein-derived Macrophage Activating Factor (GcMAF)?	Chondroitin Sulfates	3-22	GC vitamin D binding protein	Homo sapiens	80-127
27188244-6	2016	Both CS-based PEMs caused also an increased fibronectin (FN) secretion and cell growth.	Chondroitin Sulfates	5-7	fibronectin 1	Homo sapiens	44-55
27188244-7	2016	Furthermore, significant calcium phosphate deposition, enhanced ALP, Col I and Runx2 expression were observed in hADSCs on CS-based PEMs, particularly on oCS-containing one.	Chondroitin Sulfates	123-125	ATHS	Homo sapiens	64-67
27188244-7	2016	Furthermore, significant calcium phosphate deposition, enhanced ALP, Col I and Runx2 expression were observed in hADSCs on CS-based PEMs, particularly on oCS-containing one.	Chondroitin Sulfates	123-125	RUNX family transcription factor 2	Homo sapiens	79-84
27380556-7	2016	Sometimes, HIT antibodies recognize PF4 bound to (platelet-associated) chondroitin sulfate, explaining how HIT might occur without concurrent or recent heparin (delayed-onset HIT, "spontaneous HIT syndrome").	Chondroitin Sulfates	71-90	platelet factor 4	Homo sapiens	36-39
27671118-3	2016	The CS-bound HB-GAM promotes neurite growth through binding to the cell surface proteoglycan glypican-2; furthermore, HB-GAM abrogates the CS ligand binding to the inhibitory receptor PTPsigma (protein tyrosine phosphatase sigma).	Chondroitin Sulfates	139-141	pleiotrophin	Homo sapiens	118-124
27671118-3	2016	The CS-bound HB-GAM promotes neurite growth through binding to the cell surface proteoglycan glypican-2; furthermore, HB-GAM abrogates the CS ligand binding to the inhibitory receptor PTPsigma (protein tyrosine phosphatase sigma).	Chondroitin Sulfates	139-141	protein tyrosine phosphatase receptor type S	Homo sapiens	184-192
27515218-0	2016	Is chondroitin sulfate responsible for the biological effects attributed to the GC protein-derived Macrophage Activating Factor (GcMAF)?	Chondroitin Sulfates	3-22	GC vitamin D binding protein	Homo sapiens	129-134
27515218-1	2016	We hypothesize that a plasma glycosaminoglycan, chondroitin sulfate, may be responsible for the biological and clinical effects attributed to the Gc protein-derived Macrophage Activating Factor (GcMAF), a protein that is extracted from human blood.	Chondroitin Sulfates	48-67	GC vitamin D binding protein	Homo sapiens	146-193
27515218-4	2016	According to our model, the Gc protein or the GcMAF bind to chondroitin sulfate both on the cell surface and in bodily fluids, and the resulting multimolecular complexes, under the form of oligomers trigger a transmembrane signal or, alternatively, are internalized and convey the signal directly to the nucleus thus eliciting the diverse biological effects observed for both GcMAF and chondroitin sulfate.	Chondroitin Sulfates	60-79	GC vitamin D binding protein	Homo sapiens	46-51
27515218-4	2016	According to our model, the Gc protein or the GcMAF bind to chondroitin sulfate both on the cell surface and in bodily fluids, and the resulting multimolecular complexes, under the form of oligomers trigger a transmembrane signal or, alternatively, are internalized and convey the signal directly to the nucleus thus eliciting the diverse biological effects observed for both GcMAF and chondroitin sulfate.	Chondroitin Sulfates	60-79	GC vitamin D binding protein	Homo sapiens	376-381
27515218-4	2016	According to our model, the Gc protein or the GcMAF bind to chondroitin sulfate both on the cell surface and in bodily fluids, and the resulting multimolecular complexes, under the form of oligomers trigger a transmembrane signal or, alternatively, are internalized and convey the signal directly to the nucleus thus eliciting the diverse biological effects observed for both GcMAF and chondroitin sulfate.	Chondroitin Sulfates	386-405	GC vitamin D binding protein	Homo sapiens	46-51
27683612-3	2016	Versican is a chondroitin sulfate proteoglycan in the vascular extracellular matrix that accumulates following vascular injury and promotes smooth-muscle cell proliferation in systemic arteries.	Chondroitin Sulfates	14-33	versican	Homo sapiens	0-8
27445335-0	2016	Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.	Chondroitin Sulfates	8-27	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	67-111
27445335-0	2016	Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.	Chondroitin Sulfates	8-27	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	113-118
27445335-0	2016	Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.	Chondroitin Sulfates	8-27	pleiotrophin	Mus musculus	130-142
27445335-0	2016	Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.	Chondroitin Sulfates	8-27	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	143-148
27445335-0	2016	Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.	Chondroitin Sulfates	29-31	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	67-111
27445335-0	2016	Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.	Chondroitin Sulfates	29-31	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	113-118
27445335-0	2016	Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.	Chondroitin Sulfates	29-31	pleiotrophin	Mus musculus	130-142
27445335-0	2016	Role of Chondroitin Sulfate (CS) Modification in the Regulation of Protein-tyrosine Phosphatase Receptor Type Z (PTPRZ) Activity: PLEIOTROPHIN-PTPRZ-A SIGNALING IS INVOLVED IN OLIGODENDROCYTE DIFFERENTIATION.	Chondroitin Sulfates	29-31	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	143-148
27445335-3	2016	The extracellular CS moiety of PTPRZ is required for high-affinity binding to inhibitory ligands, such as pleiotrophin (PTN), midkine, and interleukin-34; however, its functional significance in regulating PTPRZ activity remains obscure.	Chondroitin Sulfates	18-20	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	31-36
27445335-3	2016	The extracellular CS moiety of PTPRZ is required for high-affinity binding to inhibitory ligands, such as pleiotrophin (PTN), midkine, and interleukin-34; however, its functional significance in regulating PTPRZ activity remains obscure.	Chondroitin Sulfates	18-20	pleiotrophin	Mus musculus	106-118
27445335-3	2016	The extracellular CS moiety of PTPRZ is required for high-affinity binding to inhibitory ligands, such as pleiotrophin (PTN), midkine, and interleukin-34; however, its functional significance in regulating PTPRZ activity remains obscure.	Chondroitin Sulfates	18-20	pleiotrophin	Mus musculus	120-123
27445335-3	2016	The extracellular CS moiety of PTPRZ is required for high-affinity binding to inhibitory ligands, such as pleiotrophin (PTN), midkine, and interleukin-34; however, its functional significance in regulating PTPRZ activity remains obscure.	Chondroitin Sulfates	18-20	interleukin 34	Mus musculus	139-153
27445335-3	2016	The extracellular CS moiety of PTPRZ is required for high-affinity binding to inhibitory ligands, such as pleiotrophin (PTN), midkine, and interleukin-34; however, its functional significance in regulating PTPRZ activity remains obscure.	Chondroitin Sulfates	18-20	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	206-211
27445335-4	2016	We herein found that protein expression of CS-modified PTPRZ-A began earlier, peaking at approximately postnatal days 5-10 (P5-P10), and then that of PTN peaked at P10 at the developmental stage corresponding to myelination onset in the mouse brain.	Chondroitin Sulfates	43-45	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	55-60
27445335-4	2016	We herein found that protein expression of CS-modified PTPRZ-A began earlier, peaking at approximately postnatal days 5-10 (P5-P10), and then that of PTN peaked at P10 at the developmental stage corresponding to myelination onset in the mouse brain.	Chondroitin Sulfates	43-45	S100 calcium binding protein A10 (calpactin)	Mus musculus	127-130
27445335-4	2016	We herein found that protein expression of CS-modified PTPRZ-A began earlier, peaking at approximately postnatal days 5-10 (P5-P10), and then that of PTN peaked at P10 at the developmental stage corresponding to myelination onset in the mouse brain.	Chondroitin Sulfates	43-45	pleiotrophin	Mus musculus	150-153
27445335-4	2016	We herein found that protein expression of CS-modified PTPRZ-A began earlier, peaking at approximately postnatal days 5-10 (P5-P10), and then that of PTN peaked at P10 at the developmental stage corresponding to myelination onset in the mouse brain.	Chondroitin Sulfates	43-45	S100 calcium binding protein A10 (calpactin)	Mus musculus	164-167
27445335-8	2016	These results indicate that the negatively charged CS moiety prevents PTPRZ from spontaneously clustering and that the positively charged ligand PTN induces PTPRZ clustering, potentially by neutralizing electrostatic repulsion between CS chains.	Chondroitin Sulfates	235-237	pleiotrophin	Mus musculus	145-148
27445335-8	2016	These results indicate that the negatively charged CS moiety prevents PTPRZ from spontaneously clustering and that the positively charged ligand PTN induces PTPRZ clustering, potentially by neutralizing electrostatic repulsion between CS chains.	Chondroitin Sulfates	235-237	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	157-162
27445335-9	2016	Taken altogether, these data indicate that PTN-PTPRZ-A signaling controls the timing of oligodendrocyte precursor cell differentiation in vivo, in which the CS moiety of PTPRZ receptors maintains them in a monomeric active state until its ligand binding.	Chondroitin Sulfates	157-159	pleiotrophin	Mus musculus	43-46
27445335-9	2016	Taken altogether, these data indicate that PTN-PTPRZ-A signaling controls the timing of oligodendrocyte precursor cell differentiation in vivo, in which the CS moiety of PTPRZ receptors maintains them in a monomeric active state until its ligand binding.	Chondroitin Sulfates	157-159	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	47-52
27445335-9	2016	Taken altogether, these data indicate that PTN-PTPRZ-A signaling controls the timing of oligodendrocyte precursor cell differentiation in vivo, in which the CS moiety of PTPRZ receptors maintains them in a monomeric active state until its ligand binding.	Chondroitin Sulfates	157-159	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	170-175
27556547-0	2016	Placental Sequestration of Plasmodium falciparum Malaria Parasites Is Mediated by the Interaction Between VAR2CSA and Chondroitin Sulfate A on Syndecan-1.	Chondroitin Sulfates	118-139	syndecan 1	Homo sapiens	143-153
27556547-8	2016	Syncytial fusion of the BeWo cells, triggered by forskolin treatment, caused an increased expression of placental CS-modified syndecan-1.	Chondroitin Sulfates	114-116	syndecan 1	Homo sapiens	126-136
27556547-9	2016	In line with this, we show that rVAR2 binding to placental CS impairs syndecan-1-related Src signaling in forskolin treated BeWo cells, but not in untreated cells.	Chondroitin Sulfates	59-61	syndecan 1	Homo sapiens	70-80
26880269-0	2016	Chondroitin sulfate prevents peritoneal fibrosis in mice by suppressing NF-kappaB activation.	Chondroitin Sulfates	0-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	72-81
26880269-2	2016	Chondroitin sulfate (CS) suppresses the inflammatory response by preventing activation of nuclear factor (NF)-kappaB.	Chondroitin Sulfates	0-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-116
26880269-2	2016	Chondroitin sulfate (CS) suppresses the inflammatory response by preventing activation of nuclear factor (NF)-kappaB.	Chondroitin Sulfates	21-23	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-116
26880269-11	2016	Based on SWH, the CG+CS group contained significantly fewer NF-kappaB-activated cells than the CG group.	Chondroitin Sulfates	21-23	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	60-69
26880269-12	2016	Our results indicate that CS suppresses peritoneal fibrosis via suppression of NF-kappaB activation.	Chondroitin Sulfates	26-28	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	79-88
27515218-1	2016	We hypothesize that a plasma glycosaminoglycan, chondroitin sulfate, may be responsible for the biological and clinical effects attributed to the Gc protein-derived Macrophage Activating Factor (GcMAF), a protein that is extracted from human blood.	Chondroitin Sulfates	48-67	GC vitamin D binding protein	Homo sapiens	195-200
27410685-3	2016	Carbohydrate sulfotransferase 15 (CHST15), which catalyzes sulfation of chondroitin sulfate to produce rare E-disaccharide units, is a novel mediator to create local fibrosis.	Chondroitin Sulfates	72-91	carbohydrate sulfotransferase 15	Homo sapiens	0-32
27427828-0	2016	Multitasking Human Lectin Galectin-3 Interacts with Sulfated Glycosaminoglycans and Chondroitin Sulfate Proteoglycans.	Chondroitin Sulfates	84-103	galectin 3	Homo sapiens	26-36
27427828-7	2016	Gal-3 interacts with unmodified heparin, chondroitin sulfate-A (CSA), -B (CSB), and -C (CSC) as well as chondroitin sulfate proteoglycans (CSPGs).	Chondroitin Sulfates	41-62	galectin 3	Homo sapiens	0-5
27427828-7	2016	Gal-3 interacts with unmodified heparin, chondroitin sulfate-A (CSA), -B (CSB), and -C (CSC) as well as chondroitin sulfate proteoglycans (CSPGs).	Chondroitin Sulfates	64-67	galectin 3	Homo sapiens	0-5
27427828-9	2016	Significantly, CSA, CSC, and a bovine CSPG were engaged in multivalent binding with Gal-3 and formed noncovalent cross-linked complexes with the lectin.	Chondroitin Sulfates	15-18	galectin 3	Homo sapiens	84-89
27427828-11	2016	Cross-linking of Gal-3 by CSA, CSC, and the bovine CSPG was reversed by beta-lactose.	Chondroitin Sulfates	26-29	galectin 3	Homo sapiens	17-22
27427828-13	2016	Hill plot analysis of calorimetric data reveals that the binding of CSA, CSC, and a bovine CSPG to Gal-3 is associated with progressive negative cooperativity effects.	Chondroitin Sulfates	68-71	galectin 3	Homo sapiens	99-104
27468113-8	2016	We also observed a clear difference in early- and late-stage complement activation (C3a and sC5b-9) with CS and CS NP triggering significant complement activation at high concentrations (0.08-0.8 mg/mL), unlike HA and HA NP.	Chondroitin Sulfates	105-107	complement C3	Homo sapiens	84-87
27567476-4	2016	On day 14, the phosphorylation of spinal p38 MAPK and subsequent increase in c-Fos-immunoreactive dorsal lumbar neurons were attenuated by the repeated administration of CS.	Chondroitin Sulfates	170-172	mitogen-activated protein kinase 14	Mus musculus	41-49
27567476-4	2016	On day 14, the phosphorylation of spinal p38 MAPK and subsequent increase in c-Fos-immunoreactive dorsal lumbar neurons were attenuated by the repeated administration of CS.	Chondroitin Sulfates	170-172	FBJ osteosarcoma oncogene	Mus musculus	77-82
27567476-5	2016	These findings suggest that CS attenuates formalin-induced tactile allodynia through the inhibition of p38 MAPK phosphorylation and subsequent up-regulation of c-Fos expression in the dorsal lumbar spinal cord.	Chondroitin Sulfates	28-30	mitogen-activated protein kinase 14	Mus musculus	103-106
27567476-5	2016	These findings suggest that CS attenuates formalin-induced tactile allodynia through the inhibition of p38 MAPK phosphorylation and subsequent up-regulation of c-Fos expression in the dorsal lumbar spinal cord.	Chondroitin Sulfates	28-30	FBJ osteosarcoma oncogene	Mus musculus	160-165
27578913-9	2016	Here we established a microanalysis method with reversed-phase ion-pair high performance liquid chromatography and found that CS in the brains of Tg2576 AD model mice show a lower molecular size and an increased ratio of CS-B motif di-sulfated disaccharide.	Chondroitin Sulfates	126-128	excision repair cross-complementing rodent repair deficiency, complementation group 6	Mus musculus	221-225
27234702-4	2016	In fact, chondroitin sulfate is capable of electrostatic interaction with positively charged growth factors, in particular, with bFGF, IGF, VEGF, PDGF and TGF-beta, resulting in their stabilization and reduced degradation in solution.	Chondroitin Sulfates	9-28	fibroblast growth factor 2	Homo sapiens	129-133
27234702-4	2016	In fact, chondroitin sulfate is capable of electrostatic interaction with positively charged growth factors, in particular, with bFGF, IGF, VEGF, PDGF and TGF-beta, resulting in their stabilization and reduced degradation in solution.	Chondroitin Sulfates	9-28	vascular endothelial growth factor A	Homo sapiens	140-144
27234702-4	2016	In fact, chondroitin sulfate is capable of electrostatic interaction with positively charged growth factors, in particular, with bFGF, IGF, VEGF, PDGF and TGF-beta, resulting in their stabilization and reduced degradation in solution.	Chondroitin Sulfates	9-28	transforming growth factor beta 1	Homo sapiens	155-163
27410685-3	2016	Carbohydrate sulfotransferase 15 (CHST15), which catalyzes sulfation of chondroitin sulfate to produce rare E-disaccharide units, is a novel mediator to create local fibrosis.	Chondroitin Sulfates	72-91	carbohydrate sulfotransferase 15	Homo sapiens	34-40
27101845-5	2016	We demonstrate that DS-epi1 is important for the generation of isolated iduronic acid residues in chondroitin sulfate (CS)/DS proteoglycans in early Xenopus embryos.	Chondroitin Sulfates	98-117	dermatan sulfate epimerase	Homo sapiens	20-27
27101845-5	2016	We demonstrate that DS-epi1 is important for the generation of isolated iduronic acid residues in chondroitin sulfate (CS)/DS proteoglycans in early Xenopus embryos.	Chondroitin Sulfates	119-121	dermatan sulfate epimerase	Homo sapiens	20-27
26914701-6	2016	The binding of bone morphogenetic protein-2 (BMP-2) in a CS concentration dependent manner and the BMP-2 release mediated osteogenic differentiation of BM-MSCs indicate the potential of CS-PEG hybrid hydrogels to promote regeneration of bone tissue.	Chondroitin Sulfates	57-59	bone morphogenetic protein 2	Homo sapiens	15-43
26914701-6	2016	The binding of bone morphogenetic protein-2 (BMP-2) in a CS concentration dependent manner and the BMP-2 release mediated osteogenic differentiation of BM-MSCs indicate the potential of CS-PEG hybrid hydrogels to promote regeneration of bone tissue.	Chondroitin Sulfates	57-59	bone morphogenetic protein 2	Homo sapiens	45-50
26914701-6	2016	The binding of bone morphogenetic protein-2 (BMP-2) in a CS concentration dependent manner and the BMP-2 release mediated osteogenic differentiation of BM-MSCs indicate the potential of CS-PEG hybrid hydrogels to promote regeneration of bone tissue.	Chondroitin Sulfates	186-188	bone morphogenetic protein 2	Homo sapiens	15-43
26914701-6	2016	The binding of bone morphogenetic protein-2 (BMP-2) in a CS concentration dependent manner and the BMP-2 release mediated osteogenic differentiation of BM-MSCs indicate the potential of CS-PEG hybrid hydrogels to promote regeneration of bone tissue.	Chondroitin Sulfates	186-188	bone morphogenetic protein 2	Homo sapiens	45-50
26914701-6	2016	The binding of bone morphogenetic protein-2 (BMP-2) in a CS concentration dependent manner and the BMP-2 release mediated osteogenic differentiation of BM-MSCs indicate the potential of CS-PEG hybrid hydrogels to promote regeneration of bone tissue.	Chondroitin Sulfates	186-188	bone morphogenetic protein 2	Homo sapiens	99-104
26917739-5	2016	Axon growth-inhibitory chondroitin sulfate proteoglycans and the extracellular matrix components fibronectin, laminin, and collagen IV were significantly up-regulated in MC-deficient and mMCP6(-/-) mice, with an increase in scar volume between 23 and 32%.	Chondroitin Sulfates	23-42	tryptase beta 2	Mus musculus	187-192
26232070-2	2016	This reaction is characterized by the retraction of cell processes, cell body swelling and increased expression of the NG2 chondroitin sulfate proteoglycan.	Chondroitin Sulfates	123-142	chondroitin sulfate proteoglycan 4	Homo sapiens	119-122
27067251-3	2016	In this study, we focus on the impacts of chondroitin sulfate A (CSA) and bovine serum albumin (BSA) on the amyloidogenic behaviors of human islet amyloid polypeptide (hIAPP) at phospholipid membranes consisting of neutral POPC and anionic POPG.	Chondroitin Sulfates	42-63	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	65-68
26650729-8	2016	This inhibitory effect was eliminated by the treatment of the SCM with chondroitinase ABC but not heparinase, suggesting that the inhibitory factor(s) secreted by NP-2 and U87MG cells was chiefly mediated by chondroitin sulfate (CS) or CS-like moiety.	Chondroitin Sulfates	208-227	neuropilin 2	Homo sapiens	163-167
26650729-8	2016	This inhibitory effect was eliminated by the treatment of the SCM with chondroitinase ABC but not heparinase, suggesting that the inhibitory factor(s) secreted by NP-2 and U87MG cells was chiefly mediated by chondroitin sulfate (CS) or CS-like moiety.	Chondroitin Sulfates	229-231	neuropilin 2	Homo sapiens	163-167
26650729-8	2016	This inhibitory effect was eliminated by the treatment of the SCM with chondroitinase ABC but not heparinase, suggesting that the inhibitory factor(s) secreted by NP-2 and U87MG cells was chiefly mediated by chondroitin sulfate (CS) or CS-like moiety.	Chondroitin Sulfates	236-238	neuropilin 2	Homo sapiens	163-167
27067251-3	2016	In this study, we focus on the impacts of chondroitin sulfate A (CSA) and bovine serum albumin (BSA) on the amyloidogenic behaviors of human islet amyloid polypeptide (hIAPP) at phospholipid membranes consisting of neutral POPC and anionic POPG.	Chondroitin Sulfates	42-63	islet amyloid polypeptide	Homo sapiens	168-173
27078017-1	2016	Arylsulfatase B (B-acetylgalactosamine 4-sulfatase; ARSB) is the enzyme that removes 4-sulfate groups from the non-reducing end of the glycosaminoglycans chondroitin 4-sulfate and dermatan sulfate.	Chondroitin Sulfates	154-175	arylsulfatase B	Homo sapiens	0-15
27078017-1	2016	Arylsulfatase B (B-acetylgalactosamine 4-sulfatase; ARSB) is the enzyme that removes 4-sulfate groups from the non-reducing end of the glycosaminoglycans chondroitin 4-sulfate and dermatan sulfate.	Chondroitin Sulfates	154-175	arylsulfatase B	Homo sapiens	52-56
27078017-6	2016	SHP2 activity declined due to increased binding with chondroitin 4-sulfate when ARSB was reduced.	Chondroitin Sulfates	53-74	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	0-4
27078017-6	2016	SHP2 activity declined due to increased binding with chondroitin 4-sulfate when ARSB was reduced.	Chondroitin Sulfates	53-74	arylsulfatase B	Homo sapiens	80-84
27078017-10	2016	The interaction between chondroitin 4-sulfate and SHP2 is a novel intersection between sulfation and phosphorylation, by which decline in ARSB and increased chondroitin 4-sulfation can inhibit SHP2, thereby regulating downstream tyrosine phosphorylations by sustained phosphorylations with associated activation of signaling and transcriptional events.	Chondroitin Sulfates	24-45	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	50-54
27078017-10	2016	The interaction between chondroitin 4-sulfate and SHP2 is a novel intersection between sulfation and phosphorylation, by which decline in ARSB and increased chondroitin 4-sulfation can inhibit SHP2, thereby regulating downstream tyrosine phosphorylations by sustained phosphorylations with associated activation of signaling and transcriptional events.	Chondroitin Sulfates	24-45	arylsulfatase B	Homo sapiens	138-142
27078017-10	2016	The interaction between chondroitin 4-sulfate and SHP2 is a novel intersection between sulfation and phosphorylation, by which decline in ARSB and increased chondroitin 4-sulfation can inhibit SHP2, thereby regulating downstream tyrosine phosphorylations by sustained phosphorylations with associated activation of signaling and transcriptional events.	Chondroitin Sulfates	24-45	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	193-197
26929154-3	2016	Lentivirus-mediated BMP7 over-expression induced differentiation of BMSCs into an NP phenotype, as indicated by expression of the NP markers collagen type II, aggrecan, SOX9 and keratins 8 and 19, increased the content of glycosaminoglycan, and up-regulated beta-1,3-glucuronosyl transferase 1, a regulator of chondroitin sulfate synthesis in NP cells.	Chondroitin Sulfates	310-329	bone morphogenetic protein 7	Oryctolagus cuniculus	20-24
26997434-1	2016	The glycosyltransferases chondroitin sulfate synthase 1 (CHSY1) and exostoses-like 3 (EXTL3) specifically function in biosynthesis of the glycans chondroitin sulfate and heparan sulfate, respectively.	Chondroitin Sulfates	25-44	chondroitin sulfate synthase 1	Homo sapiens	57-62
26997434-1	2016	The glycosyltransferases chondroitin sulfate synthase 1 (CHSY1) and exostoses-like 3 (EXTL3) specifically function in biosynthesis of the glycans chondroitin sulfate and heparan sulfate, respectively.	Chondroitin Sulfates	25-44	exostosin like glycosyltransferase 3	Homo sapiens	68-84
26997434-1	2016	The glycosyltransferases chondroitin sulfate synthase 1 (CHSY1) and exostoses-like 3 (EXTL3) specifically function in biosynthesis of the glycans chondroitin sulfate and heparan sulfate, respectively.	Chondroitin Sulfates	25-44	exostosin like glycosyltransferase 3	Homo sapiens	86-91
26547427-6	2016	For high sensitivity applications, G-FETs were functionalized by monoclonal antibodies specific to cancer biomarker chondroitin sulfate proteoglycan 4, enabling its detection at a concentration of 0.01 fM, five orders of magnitude lower than that detectable by a conventional colorimetric assay.	Chondroitin Sulfates	116-135	proteoglycan 4	Homo sapiens	136-150
27009190-4	2016	Halo-FGF1, Halo-FGF2 and Halo-FGF6 bound to HS, whereas Halo-FGF10 also interacted with chondroitin sulfate/dermatan sulfate, and FGF20 did not bind detectably.	Chondroitin Sulfates	88-107	fibroblast growth factor 10	Rattus norvegicus	61-66
26226327-0	2016	Acute Exacerbations of COPD Are Associated With Increased Expression of Heparan Sulfate and Chondroitin Sulfate in BAL.	Chondroitin Sulfates	92-111	poly(ADP-ribose) polymerase family member 9	Homo sapiens	115-118
26226327-6	2016	RESULTS: Heparan sulfate and chondroitin sulfate were significantly increased in BAL of patients during exacerbations.	Chondroitin Sulfates	29-48	poly(ADP-ribose) polymerase family member 9	Homo sapiens	81-84
26226327-9	2016	Furthermore, heparan sulfate and chondroitin sulfate were significantly correlated with MMP-9, MMP-2, and MMP-12 in BAL, indicating that they were cleaved from their respective proteoglycans by MMPs and subsequently washed out in BAL.	Chondroitin Sulfates	33-52	matrix metallopeptidase 9	Homo sapiens	88-93
26226327-9	2016	Furthermore, heparan sulfate and chondroitin sulfate were significantly correlated with MMP-9, MMP-2, and MMP-12 in BAL, indicating that they were cleaved from their respective proteoglycans by MMPs and subsequently washed out in BAL.	Chondroitin Sulfates	33-52	matrix metallopeptidase 2	Homo sapiens	95-100
26226327-9	2016	Furthermore, heparan sulfate and chondroitin sulfate were significantly correlated with MMP-9, MMP-2, and MMP-12 in BAL, indicating that they were cleaved from their respective proteoglycans by MMPs and subsequently washed out in BAL.	Chondroitin Sulfates	33-52	matrix metallopeptidase 12	Homo sapiens	106-112
26226327-9	2016	Furthermore, heparan sulfate and chondroitin sulfate were significantly correlated with MMP-9, MMP-2, and MMP-12 in BAL, indicating that they were cleaved from their respective proteoglycans by MMPs and subsequently washed out in BAL.	Chondroitin Sulfates	33-52	poly(ADP-ribose) polymerase family member 9	Homo sapiens	116-119
26226327-9	2016	Furthermore, heparan sulfate and chondroitin sulfate were significantly correlated with MMP-9, MMP-2, and MMP-12 in BAL, indicating that they were cleaved from their respective proteoglycans by MMPs and subsequently washed out in BAL.	Chondroitin Sulfates	33-52	matrix metallopeptidase 2	Homo sapiens	194-198
26226327-9	2016	Furthermore, heparan sulfate and chondroitin sulfate were significantly correlated with MMP-9, MMP-2, and MMP-12 in BAL, indicating that they were cleaved from their respective proteoglycans by MMPs and subsequently washed out in BAL.	Chondroitin Sulfates	33-52	poly(ADP-ribose) polymerase family member 9	Homo sapiens	230-233
26226327-10	2016	CONCLUSIONS: During AECOPD, there is increased expression of heparan sulfate and chondroitin sulfate in BAL.	Chondroitin Sulfates	81-100	poly(ADP-ribose) polymerase family member 9	Homo sapiens	104-107
26731725-7	2016	The CHST15 gene, responsible for the biosynthesis of highly sulfated CS was evaluated for mutation and methylation status.	Chondroitin Sulfates	69-71	carbohydrate sulfotransferase 15	Homo sapiens	4-10
26896299-0	2016	Structural studies reveal an important role for the pleiotrophin C-terminus in mediating interactions with chondroitin sulfate.	Chondroitin Sulfates	107-126	pleiotrophin	Homo sapiens	52-64
26896299-2	2016	Much of its activity is attributed to its interactions with the chondroitin sulfate (CS) proteoglycan, receptor type protein tyrosine phosphatase zeta (PTPRZ).	Chondroitin Sulfates	64-83	protein tyrosine phosphatase receptor type Z1	Homo sapiens	152-157
26896299-4	2016	We determined the first structure of PTN and analyzed its interactions with CS.	Chondroitin Sulfates	76-78	pleiotrophin	Homo sapiens	37-40
26896299-6	2016	Our analysis of PTN-CS interactions showed that the C-terminal tail of PTN is essential for maintaining stable interactions with chondroitin sulfate A, the type of CS commonly found on PTPRZ.	Chondroitin Sulfates	129-150	pleiotrophin	Homo sapiens	16-19
26896299-6	2016	Our analysis of PTN-CS interactions showed that the C-terminal tail of PTN is essential for maintaining stable interactions with chondroitin sulfate A, the type of CS commonly found on PTPRZ.	Chondroitin Sulfates	129-150	pleiotrophin	Homo sapiens	71-74
26896299-6	2016	Our analysis of PTN-CS interactions showed that the C-terminal tail of PTN is essential for maintaining stable interactions with chondroitin sulfate A, the type of CS commonly found on PTPRZ.	Chondroitin Sulfates	129-150	protein tyrosine phosphatase receptor type Z1	Homo sapiens	185-190
26896299-6	2016	Our analysis of PTN-CS interactions showed that the C-terminal tail of PTN is essential for maintaining stable interactions with chondroitin sulfate A, the type of CS commonly found on PTPRZ.	Chondroitin Sulfates	20-22	pleiotrophin	Homo sapiens	16-19
26896299-6	2016	Our analysis of PTN-CS interactions showed that the C-terminal tail of PTN is essential for maintaining stable interactions with chondroitin sulfate A, the type of CS commonly found on PTPRZ.	Chondroitin Sulfates	20-22	pleiotrophin	Homo sapiens	71-74
26896299-6	2016	Our analysis of PTN-CS interactions showed that the C-terminal tail of PTN is essential for maintaining stable interactions with chondroitin sulfate A, the type of CS commonly found on PTPRZ.	Chondroitin Sulfates	20-22	protein tyrosine phosphatase receptor type Z1	Homo sapiens	185-190
26896299-8	2016	NMR analysis of the interactions of PTN with CS revealed that the C-terminal domain and hinge of PTN make up the major CS-binding site in PTN, and that removal of the C-terminal tail weakened the affinity of the site for CSA but not for other high sulfation density CS.	Chondroitin Sulfates	45-47	pleiotrophin	Homo sapiens	36-39
26896299-8	2016	NMR analysis of the interactions of PTN with CS revealed that the C-terminal domain and hinge of PTN make up the major CS-binding site in PTN, and that removal of the C-terminal tail weakened the affinity of the site for CSA but not for other high sulfation density CS.	Chondroitin Sulfates	45-47	pleiotrophin	Homo sapiens	97-100
26896299-8	2016	NMR analysis of the interactions of PTN with CS revealed that the C-terminal domain and hinge of PTN make up the major CS-binding site in PTN, and that removal of the C-terminal tail weakened the affinity of the site for CSA but not for other high sulfation density CS.	Chondroitin Sulfates	45-47	pleiotrophin	Homo sapiens	97-100
26896299-8	2016	NMR analysis of the interactions of PTN with CS revealed that the C-terminal domain and hinge of PTN make up the major CS-binding site in PTN, and that removal of the C-terminal tail weakened the affinity of the site for CSA but not for other high sulfation density CS.	Chondroitin Sulfates	119-121	pleiotrophin	Homo sapiens	36-39
26896299-8	2016	NMR analysis of the interactions of PTN with CS revealed that the C-terminal domain and hinge of PTN make up the major CS-binding site in PTN, and that removal of the C-terminal tail weakened the affinity of the site for CSA but not for other high sulfation density CS.	Chondroitin Sulfates	119-121	pleiotrophin	Homo sapiens	97-100
26896299-8	2016	NMR analysis of the interactions of PTN with CS revealed that the C-terminal domain and hinge of PTN make up the major CS-binding site in PTN, and that removal of the C-terminal tail weakened the affinity of the site for CSA but not for other high sulfation density CS.	Chondroitin Sulfates	119-121	pleiotrophin	Homo sapiens	97-100
26896299-8	2016	NMR analysis of the interactions of PTN with CS revealed that the C-terminal domain and hinge of PTN make up the major CS-binding site in PTN, and that removal of the C-terminal tail weakened the affinity of the site for CSA but not for other high sulfation density CS.	Chondroitin Sulfates	119-121	pleiotrophin	Homo sapiens	36-39
26896299-8	2016	NMR analysis of the interactions of PTN with CS revealed that the C-terminal domain and hinge of PTN make up the major CS-binding site in PTN, and that removal of the C-terminal tail weakened the affinity of the site for CSA but not for other high sulfation density CS.	Chondroitin Sulfates	119-121	pleiotrophin	Homo sapiens	97-100
26896299-8	2016	NMR analysis of the interactions of PTN with CS revealed that the C-terminal domain and hinge of PTN make up the major CS-binding site in PTN, and that removal of the C-terminal tail weakened the affinity of the site for CSA but not for other high sulfation density CS.	Chondroitin Sulfates	119-121	pleiotrophin	Homo sapiens	97-100
26728454-2	2016	The protein consists of three subunits, heavy chain 1, heavy chain 2, and bikunin covalently joined by a chondroitin sulfate chain originating at Ser-10 of bikunin.	Chondroitin Sulfates	105-124	alpha-1-microglobulin/bikunin precursor	Homo sapiens	156-163
26728454-7	2016	The results showed that Mg(2+) or Mn(2+), but not Ca(2+), induced a conformational change in inter-alpha-inhibitor as evidenced by a decrease in the Stokes radius and a bikunin chondroitin sulfate-dependent increase of the thermodynamic stability.	Chondroitin Sulfates	177-196	alpha-1-microglobulin/bikunin precursor	Homo sapiens	169-176
26656789-3	2016	This study was undertaken to determine if modification of CFTR by small molecule correctors or potentiators could also increase ARSB and reduce the accumulation of chondroitin 4-sulfate (C4S).	Chondroitin Sulfates	164-185	CF transmembrane conductance regulator	Homo sapiens	58-62
26878059-7	2016	These molecules synthesized with chondroitin sulfate backbones conjugated to hyaluronan- or collagen type II- binding peptides, are capable of diffusing through a cartilage explant and adhering to the ECM of this tissue.	Chondroitin Sulfates	33-52	collagen alpha-1(II) chain	Cavia porcellus	92-108
26878059-9	2016	Different variations of chondroitin sulfate conjugated to the binding peptides were diffused through aggrecan depleted explants and assessed for their ability to enhance compressive stiffness, prevent CS degradation, and modulate catabolic (MMP-13 and ADAMTS-5) and anabolic (aggrecan and collagen type II) gene expression.	Chondroitin Sulfates	24-43	collagenase 3	Cavia porcellus	241-247
26714044-6	2016	RESULTS: Treatment of obese mice with CS reduced the extension of foam cell coverage in atheromatous plaques of arterial bifurcations by 62.5%, the serum concentration of IL1beta by 70%, TNF-alpha by 82% and selected chemokines by 25-35%.	Chondroitin Sulfates	38-40	interleukin 1 beta	Mus musculus	171-178
26714044-6	2016	RESULTS: Treatment of obese mice with CS reduced the extension of foam cell coverage in atheromatous plaques of arterial bifurcations by 62.5%, the serum concentration of IL1beta by 70%, TNF-alpha by 82% and selected chemokines by 25-35%.	Chondroitin Sulfates	38-40	tumor necrosis factor	Mus musculus	187-196
26714044-7	2016	Cultures of coronary endothelial cells and monocytes stimulated with TNF-alpha secreted less pro-inflammatory cytokines in the presence of CS (P &lt; 0.01).	Chondroitin Sulfates	139-141	tumor necrosis factor	Homo sapiens	69-78
26714044-8	2016	CS reduced the activation of the TNF-alpha signaling pathway in endothelial cells (pErk 36% of reduction, and NFkappaB 33% of reduction), and the migration of activated monocytes to inflamed endothelial cells in transwells (81 +- 6 vs. 13 +- 2, P &lt; 0.001).	Chondroitin Sulfates	0-2	tumor necrosis factor	Homo sapiens	33-42
26714044-8	2016	CS reduced the activation of the TNF-alpha signaling pathway in endothelial cells (pErk 36% of reduction, and NFkappaB 33% of reduction), and the migration of activated monocytes to inflamed endothelial cells in transwells (81 +- 6 vs. 13 +- 2, P &lt; 0.001).	Chondroitin Sulfates	0-2	nuclear factor kappa B subunit 1	Homo sapiens	110-118
26714044-9	2016	CONCLUSIONS: CS interferes with the pro-inflammatory activation of monocytes and endothelial cells driven by TNF-alpha thus reducing the propagation of inflammation and preventing the formation of atherosclerotic plaques.	Chondroitin Sulfates	13-15	tumor necrosis factor	Homo sapiens	109-118
26577936-13	2016	CONCLUSION: These results suggest that intra-articular injections of Arthrum HCS( ) (sodium hyaluronate plus chondroitin sulfate) in patients with knee osteoarthritis are efficient and safe.	Chondroitin Sulfates	109-128	holocarboxylase synthetase	Homo sapiens	77-80
26656789-3	2016	This study was undertaken to determine if modification of CFTR by small molecule correctors or potentiators could also increase ARSB and reduce the accumulation of chondroitin 4-sulfate (C4S).	Chondroitin Sulfates	187-190	CF transmembrane conductance regulator	Homo sapiens	58-62
26601955-4	2016	The HC-HA modification involves the transfer of heavy chains from the inter-alpha-inhibitor (IalphaI) proteoglycan, which has two heavy chains (HC1 and HC2) on its chondroitin sulfate chain.	Chondroitin Sulfates	164-183	heterochromatin, Chr 2	Mus musculus	152-155
26601955-5	2016	The transesterification transfer of HCs from chondroitin sulfate to HA is mediated by tumor necrosis factor-induced gene 6 (TSG-6), which is up-regulated in inflammatory reactions.	Chondroitin Sulfates	45-64	tumor necrosis factor alpha induced protein 6	Mus musculus	86-122
26601955-5	2016	The transesterification transfer of HCs from chondroitin sulfate to HA is mediated by tumor necrosis factor-induced gene 6 (TSG-6), which is up-regulated in inflammatory reactions.	Chondroitin Sulfates	45-64	tumor necrosis factor alpha induced protein 6	Mus musculus	124-129
26485166-3	2016	In this study, we explore the potential of an oriented immobilization technique based on two high affinity peptides, namely the Ecoil and Kcoil, to allow for the simultaneous capture of the epidermal growth factor (EGF) and the vascular endothelial growth factor (VEGF) on a chondroitin sulfate coating.	Chondroitin Sulfates	275-294	epidermal growth factor	Homo sapiens	190-213
26485166-3	2016	In this study, we explore the potential of an oriented immobilization technique based on two high affinity peptides, namely the Ecoil and Kcoil, to allow for the simultaneous capture of the epidermal growth factor (EGF) and the vascular endothelial growth factor (VEGF) on a chondroitin sulfate coating.	Chondroitin Sulfates	275-294	epidermal growth factor	Homo sapiens	215-218
26485166-3	2016	In this study, we explore the potential of an oriented immobilization technique based on two high affinity peptides, namely the Ecoil and Kcoil, to allow for the simultaneous capture of the epidermal growth factor (EGF) and the vascular endothelial growth factor (VEGF) on a chondroitin sulfate coating.	Chondroitin Sulfates	275-294	vascular endothelial growth factor A	Homo sapiens	228-262
26288008-4	2016	Absence of chondroitin sulfate in the neural plate leads to reduced Sox2 expression and is accompanied by an increase in the expression of anterior markers of neural regionalization.	Chondroitin Sulfates	11-30	SRY-box 2	Gallus gallus	68-72
26821980-1	2016	A previously validated method for determination of chondroitin sulfate in raw materials and dietary supplements was submitted to the AOAC Expert Review Panel (ERP) for Stakeholder Panel on Dietary Supplements Set 1 Ingredients (Anthocyanins, Chondroitin, and PDE5 Inhibitors) for consideration of First Action Official Methods(SM) status.	Chondroitin Sulfates	51-70	SET domain containing 1A, histone lysine methyltransferase	Homo sapiens	209-214
27057358-4	2016	However, the mechanism of PNN formation regulated by CS sulfation remains unknown.	Chondroitin Sulfates	53-55	pinin, desmosome associated protein	Homo sapiens	26-29
26347576-6	2016	Second, C1INH bound to host CD36 and chondroitin sulfate A molecules, interfering with cytoadhesion of infected RBCs by competitive binding to these receptors in vitro and reducing sequestration in specific tissues and protecting against ECM in vivo.	Chondroitin Sulfates	37-58	serpin family G member 1	Homo sapiens	8-13
27057358-5	2016	Here we found that overexpression of chondroitin 6-sulfotransferase-1 (C6ST-1), which catalyzes 6-sulfation of CS chains, selectively decreased aggrecan, a major CSPG in PNNs, in the aged brain without affecting other PNN components.	Chondroitin Sulfates	111-113	carbohydrate sulfotransferase 3	Homo sapiens	37-69
27057358-5	2016	Here we found that overexpression of chondroitin 6-sulfotransferase-1 (C6ST-1), which catalyzes 6-sulfation of CS chains, selectively decreased aggrecan, a major CSPG in PNNs, in the aged brain without affecting other PNN components.	Chondroitin Sulfates	111-113	carbohydrate sulfotransferase 3	Homo sapiens	71-77
27057358-7	2016	C6ST-1 increased 6-sulfation in both the repeating disaccharide region and linkage region of CS chains.	Chondroitin Sulfates	93-95	carbohydrate sulfotransferase 3	Homo sapiens	0-6
27057361-6	2016	Sema3A interacts with high-affinity with chondroitin sulfate E, a component of PNN.	Chondroitin Sulfates	41-60	semaphorin 3A	Rattus norvegicus	0-6
26646821-3	2015	In a murine model of elastase-induced pulmonary emphysema, we found increased carbohydrate sulfotransferase 3 (CHST3), a specific enzyme that synthesizes chondroitin 6-sulfate proteoglycan (C6SPG).	Chondroitin Sulfates	154-175	carbohydrate sulfotransferase 3	Mus musculus	78-109
27190523-8	2016	Moreover, the CS-Col I membrane with CS on the top layer showed the most effects on promoting EPCs proliferation, EPCs-MV release, and miR-126 level in EPCs-MVs.	Chondroitin Sulfates	14-16	microRNA 126	Homo sapiens	135-142
27190523-8	2016	Moreover, the CS-Col I membrane with CS on the top layer showed the most effects on promoting EPCs proliferation, EPCs-MV release, and miR-126 level in EPCs-MVs.	Chondroitin Sulfates	37-39	microRNA 126	Homo sapiens	135-142
27190523-9	2016	In conclusion, HA/CS and Collagen I composed multilayer composite membranes can promote EPCs functions and release of miR-126 riched EPCs-MVs, which provides a novel strategy for tissue repair treatment.	Chondroitin Sulfates	18-20	microRNA 126	Homo sapiens	118-125
26646821-3	2015	In a murine model of elastase-induced pulmonary emphysema, we found increased carbohydrate sulfotransferase 3 (CHST3), a specific enzyme that synthesizes chondroitin 6-sulfate proteoglycan (C6SPG).	Chondroitin Sulfates	154-175	carbohydrate sulfotransferase 3	Mus musculus	111-116
26385570-1	2015	Versican, a chondroitin sulfate proteoglycan, is important in embryonic development, and disruption of the versican gene is embryonically lethal in the mouse.	Chondroitin Sulfates	12-31	versican	Mus musculus	0-8
26598704-5	2015	We show that exposure of neurons to growth-limiting molecules--such as myelin-derived Nogo and myelin-associated glycoprotein--or reactive astrocyte-produced chondroitin sulfate proteoglycans activates PARP1, resulting in the accumulation of poly(ADP-ribose) in the cell body and axon and limited axonal growth.	Chondroitin Sulfates	158-177	poly(ADP-ribose) polymerase 1	Homo sapiens	202-207
26454548-0	2015	Inhibition of cell proliferation and migration by chondroitin sulfate-g-polyethylenimine-mediated miR-34a delivery.	Chondroitin Sulfates	50-69	microRNA 34a	Homo sapiens	98-105
26454548-1	2015	Chondroitin sulfate was chemically conjugated to PEI25K through Michael addition to construct a non-viral gene carrier CS-PEI, and then the carrier was employed in miR-34a delivery to achieve the inhibition of cell proliferation and migration, using prostate tumor cell PC-3 as a model.	Chondroitin Sulfates	0-19	microRNA 34a	Homo sapiens	164-171
26014103-3	2015	The CS showed a sustained release up to 3 days from CSL and 14 days from CSH fibers.	Chondroitin Sulfates	4-6	chorionic somatomammotropin hormone like 1	Homo sapiens	52-55
26407992-1	2015	The inter-alpha-trypsin inhibitor complex is a macromolecular arrangement of structurally related heavy chain proteins covalently cross-linked to the chondroitin sulfate (CS) chain of the proteoglycan bikunin.	Chondroitin Sulfates	150-169	alpha-1-microglobulin/bikunin precursor	Homo sapiens	201-208
26407992-1	2015	The inter-alpha-trypsin inhibitor complex is a macromolecular arrangement of structurally related heavy chain proteins covalently cross-linked to the chondroitin sulfate (CS) chain of the proteoglycan bikunin.	Chondroitin Sulfates	171-173	alpha-1-microglobulin/bikunin precursor	Homo sapiens	201-208
26407992-5	2015	The cross-linkage region of the bikunin CS chain is located in the nonsulfated nonreducing end, (GalNAcbeta4GlcAbeta3)(n), to which heavy chains (H1-H3) may be bound in GalNAc to Asp ester linkages.	Chondroitin Sulfates	40-42	alpha-1-microglobulin/bikunin precursor	Homo sapiens	32-39
26407992-8	2015	The analyses demonstrated that the CS linkage region of bikunin is highly heterogeneous.	Chondroitin Sulfates	35-37	alpha-1-microglobulin/bikunin precursor	Homo sapiens	56-63
26395512-1	2015	OBJECTIVE: Versican is a versatile and highly interactive chondroitin sulfate proteoglycan that is found in the extracellular matrix (ECM) of many tissues and is a major component of developing and developed lesions in atherosclerotic vascular disease.	Chondroitin Sulfates	58-77	versican	Rattus norvegicus	11-19
26218495-6	2015	PIC micelles prepared with CS show a higher stability than those prepared with HA, probably due to strong interactions between guanidium cations in PEG-b-PArg and carboxylate/sulfate in CS.	Chondroitin Sulfates	27-29	poly(ADP-ribose) glycohydrolase	Homo sapiens	154-158
26249591-2	2015	Chondroitin sulfate (CS) was then used as a coating polymer to shield the surface charge of ESP/pDNA complexes, as well as a tumor targeting entity to ensure specific delivery of CS/ESP/pDNA complexes.	Chondroitin Sulfates	0-19	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	92-95
26249591-2	2015	Chondroitin sulfate (CS) was then used as a coating polymer to shield the surface charge of ESP/pDNA complexes, as well as a tumor targeting entity to ensure specific delivery of CS/ESP/pDNA complexes.	Chondroitin Sulfates	0-19	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	179-185
26249591-2	2015	Chondroitin sulfate (CS) was then used as a coating polymer to shield the surface charge of ESP/pDNA complexes, as well as a tumor targeting entity to ensure specific delivery of CS/ESP/pDNA complexes.	Chondroitin Sulfates	21-23	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	92-95
26249591-2	2015	Chondroitin sulfate (CS) was then used as a coating polymer to shield the surface charge of ESP/pDNA complexes, as well as a tumor targeting entity to ensure specific delivery of CS/ESP/pDNA complexes.	Chondroitin Sulfates	21-23	protein tyrosine phosphatase receptor type V, pseudogene	Homo sapiens	179-185
26342034-8	2015	In agreement with this, the absence of Ctr2 caused a skewed ratio between proteoglycans of heparin and chondroitin sulfate type, with increased amounts of heparin accompanied by a reduction of chondroitin sulfate.	Chondroitin Sulfates	103-122	solute carrier family 31 member 2	Homo sapiens	39-43
26407992-3	2015	Bikunin is modified at Ser-10 by a single low-sulfated CS chain of 23-55 monosaccharides with 4-9 sulfate groups.	Chondroitin Sulfates	55-57	alpha-1-microglobulin/bikunin precursor	Homo sapiens	0-7
26461094-3	2015	In tumors, placental-like CS chains are linked to a limited repertoire of cancer-associated proteoglycans including CD44 and CSPG4.	Chondroitin Sulfates	26-28	CD44 molecule (Indian blood group)	Homo sapiens	116-120
26461094-3	2015	In tumors, placental-like CS chains are linked to a limited repertoire of cancer-associated proteoglycans including CD44 and CSPG4.	Chondroitin Sulfates	26-28	chondroitin sulfate proteoglycan 4	Homo sapiens	125-130
27005260-0	2015	Chemically conjugating poly(amidoamine) with chondroitin sulfate to promote CD44-mediated endocytosis for miR-34a delivery.	Chondroitin Sulfates	45-64	CD44 molecule (Indian blood group)	Homo sapiens	76-80
26218733-12	2015	SIGNIFICANCE: Our findings indicate that neuron density and chondroitin sulfate immunopositive area in the CA1 subfield are crucial for the hippocampal volume, and that chondroitin sulfate is important for the maintenance of a normal hippocampal volume in some cases with severe neuron loss.	Chondroitin Sulfates	60-79	carbonic anhydrase 1	Homo sapiens	107-110
26218733-12	2015	SIGNIFICANCE: Our findings indicate that neuron density and chondroitin sulfate immunopositive area in the CA1 subfield are crucial for the hippocampal volume, and that chondroitin sulfate is important for the maintenance of a normal hippocampal volume in some cases with severe neuron loss.	Chondroitin Sulfates	169-188	carbonic anhydrase 1	Homo sapiens	107-110
26254241-0	2015	Protective effects of low molecular weight chondroitin sulfate on amyloid beta (Abeta)-induced damage in vitro and in vivo.	Chondroitin Sulfates	43-62	amyloid beta (A4) precursor protein	Mus musculus	80-85
27005260-0	2015	Chemically conjugating poly(amidoamine) with chondroitin sulfate to promote CD44-mediated endocytosis for miR-34a delivery.	Chondroitin Sulfates	45-64	microRNA 34a	Homo sapiens	106-113
26381016-5	2015	Pretreatment with heparitinase and chondroitinase ABC decreased the HGF and FGF2 responses, respectively, in non-knockdown cultures, supporting a possible model that HGF and FGF2 may bind to heparan and chondroitin sulfate chains of syndecan-2, 4 to signal Sema3A expression.	Chondroitin Sulfates	203-222	fibroblast growth factor 2	Homo sapiens	174-178
26045614-7	2015	Milk-borne TGF-beta2 was bound to chondroitin sulfate (CS) containing proteoglycan(s) such as biglycan, which are expressed in high concentrations in milk.	Chondroitin Sulfates	34-53	transforming growth factor beta 2	Homo sapiens	11-20
25999281-5	2015	Exogenous CS reduced insoluble elastin, even in the presence of V1 siRNA.	Chondroitin Sulfates	10-12	elastin	Homo sapiens	31-38
25999281-6	2015	These findings confirm that V1 and CS impair the assembly of tropoelastin monomers into insoluble fibers, and further demonstrate that specific knockdown of V1 alleviates the impaired assembly of elastin seen in cultures of pulmonary fibroblasts exposed to CSE, indicating a regulatory role for this protein in the pathophysiology of COPD.	Chondroitin Sulfates	35-37	elastin	Homo sapiens	61-73
25999281-6	2015	These findings confirm that V1 and CS impair the assembly of tropoelastin monomers into insoluble fibers, and further demonstrate that specific knockdown of V1 alleviates the impaired assembly of elastin seen in cultures of pulmonary fibroblasts exposed to CSE, indicating a regulatory role for this protein in the pathophysiology of COPD.	Chondroitin Sulfates	35-37	elastin	Homo sapiens	66-73
26045614-7	2015	Milk-borne TGF-beta2 was bound to chondroitin sulfate (CS) containing proteoglycan(s) such as biglycan, which are expressed in high concentrations in milk.	Chondroitin Sulfates	55-57	transforming growth factor beta 2	Homo sapiens	11-20
26172013-1	2015	Mucopolysaccharidosis type IV-A (Morquio A disease) is an autosomal recessive lysosomal storage disease caused by mutations in the gene encoding the N-acetylgalactosamine-6-sulfate sulfatase, that results in impaired catabolism of two glycosaminoglycans, chondroitin-6-sulfate and keratan sulfate.	Chondroitin Sulfates	255-276	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	149-190
26149228-5	2015	The cellular uptake of DOX from the CSA-DOCA NPs in CD44 receptor-positive human breast adenocarcinoma MDA-MB-231 cells was reduced when co-treated with free CSA, indicating the interaction between CSA and the CD44 receptor.	Chondroitin Sulfates	36-39	CD44 molecule (Indian blood group)	Homo sapiens	52-56
26149228-5	2015	The cellular uptake of DOX from the CSA-DOCA NPs in CD44 receptor-positive human breast adenocarcinoma MDA-MB-231 cells was reduced when co-treated with free CSA, indicating the interaction between CSA and the CD44 receptor.	Chondroitin Sulfates	36-39	CD44 molecule (Indian blood group)	Homo sapiens	210-214
26149228-5	2015	The cellular uptake of DOX from the CSA-DOCA NPs in CD44 receptor-positive human breast adenocarcinoma MDA-MB-231 cells was reduced when co-treated with free CSA, indicating the interaction between CSA and the CD44 receptor.	Chondroitin Sulfates	158-161	CD44 molecule (Indian blood group)	Homo sapiens	210-214
26295140-2	2015	Efficient gene transfection is realized by chondroitin sulfate (ChS) that promotes CD44- mediated endocytosis and enhances the cellular uptake of CP/pDNA polyplexes besides clathrin-mediated endocytosis.	Chondroitin Sulfates	43-62	CD44 molecule (Indian blood group)	Homo sapiens	83-87
26295140-2	2015	Efficient gene transfection is realized by chondroitin sulfate (ChS) that promotes CD44- mediated endocytosis and enhances the cellular uptake of CP/pDNA polyplexes besides clathrin-mediated endocytosis.	Chondroitin Sulfates	64-67	CD44 molecule (Indian blood group)	Homo sapiens	83-87
25943740-0	2015	Decline in arylsulfatase B and Increase in chondroitin 4-sulfotransferase combine to increase chondroitin 4-sulfate in traumatic brain injury.	Chondroitin Sulfates	94-115	arylsulfatase B	Rattus norvegicus	11-26
25943740-2	2015	In addition, the ARSB substrate chondroitin 4-sulfate (C4S) and total sulfated glycosaminoglycans increased.	Chondroitin Sulfates	32-53	arylsulfatase B	Rattus norvegicus	17-21
25943740-2	2015	In addition, the ARSB substrate chondroitin 4-sulfate (C4S) and total sulfated glycosaminoglycans increased.	Chondroitin Sulfates	55-58	arylsulfatase B	Rattus norvegicus	17-21
25943740-3	2015	The mRNA expression of chondroitin 4-sulfotransferase 1 (C4ST1; CHST11) and the sulfotransferase activity rose at the ipsilateral site of injury (PBBI-I), indicating contributions from both increased production and reduced degradation to the accumulation of C4S.	Chondroitin Sulfates	57-60	carbohydrate sulfotransferase 11	Rattus norvegicus	23-55
25943740-10	2015	Following penetrating ballistic-like brain injury in a rat model and in the scratch model of injury in fetal rat astrocytes, Arylsulfatase B activity declined, leading to accumulation of C4S.	Chondroitin Sulfates	187-190	arylsulfatase B	Rattus norvegicus	125-140
26033682-0	2015	Anti-oxidation and Antiapoptotic Effects of Chondroitin Sulfate on 6-Hydroxydopamine-Induced Injury Through the Up-Regulation of Nrf2 and Inhibition of Mitochondria-Mediated Pathway.	Chondroitin Sulfates	44-63	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
26033682-3	2015	The subsequent mechanism study showed that the anti-oxidation of CS may partly be mediated through inhibiting the intracellular reactive oxygen species overproduction, recovering the reduction of nuclear NF-E2-related factor-2 (Nrf2) expression and the reduction of antioxidants activity induced by 6-OHDA.	Chondroitin Sulfates	65-67	NFE2 like bZIP transcription factor 2	Homo sapiens	204-226
26033682-3	2015	The subsequent mechanism study showed that the anti-oxidation of CS may partly be mediated through inhibiting the intracellular reactive oxygen species overproduction, recovering the reduction of nuclear NF-E2-related factor-2 (Nrf2) expression and the reduction of antioxidants activity induced by 6-OHDA.	Chondroitin Sulfates	65-67	NFE2 like bZIP transcription factor 2	Homo sapiens	228-232
26033682-6	2015	These results suggest that CS exhibits anti-oxidation through the up-regulation of Nrf2 along with endogenous antioxidant, and reduces apoptosis via inhibiting the mitochondrial pathway to protect SH-SY5Y cells damaged by 6-OHDA.	Chondroitin Sulfates	27-29	NFE2 like bZIP transcription factor 2	Homo sapiens	83-87
25907054-3	2015	We modified a Streptococcal collagen-like 2 protein with hyaluronic acid (HA) or chondroitin sulfate (CS)-binding peptides and then cross-linked with a matrix metalloproteinase 7 (MMP7)-sensitive peptide to form biodegradable hydrogels.	Chondroitin Sulfates	81-100	matrix metallopeptidase 7	Homo sapiens	152-178
25828361-8	2015	We screened the key genes CHSY3, B3GAT1, CHPF, and B4GALT7 which was significantly expressed in CS pathway.	Chondroitin Sulfates	96-98	chondroitin sulfate synthase 3	Gallus gallus	26-31
25828361-8	2015	We screened the key genes CHSY3, B3GAT1, CHPF, and B4GALT7 which was significantly expressed in CS pathway.	Chondroitin Sulfates	96-98	beta-1,3-glucuronyltransferase 1	Gallus gallus	33-39
25828361-8	2015	We screened the key genes CHSY3, B3GAT1, CHPF, and B4GALT7 which was significantly expressed in CS pathway.	Chondroitin Sulfates	96-98	chondroitin polymerizing factor	Gallus gallus	41-45
25828361-8	2015	We screened the key genes CHSY3, B3GAT1, CHPF, and B4GALT7 which was significantly expressed in CS pathway.	Chondroitin Sulfates	96-98	beta-1,4-galactosyltransferase 7	Gallus gallus	51-58
25907054-5	2015	Hydrogels functionalized with CS-binding peptides also led to significantly higher MMP7 gene expression and activity while the HA-binding peptides significantly increased chondrogenic differentiation of the hMSCs.	Chondroitin Sulfates	30-32	matrix metallopeptidase 7	Homo sapiens	83-87
25995222-4	2015	RPTPsigma is reciprocally regulated by interactions with chondroitin sulfate or heparan sulfate containing extracellular proteoglycans in a mechanism called the proteoglycan switch.	Chondroitin Sulfates	57-76	protein tyrosine phosphatase receptor type S	Homo sapiens	0-9
25906376-3	2015	Because of the dimer repeat, the CS glycosidic "backbone" has two distinct sets of conformational degrees of freedom defined by pairs of dihedral angles: (phi1, psi1) about the beta1-3 glycosidic linkage and (phi2, psi2) about the beta1-4 glycosidic linkage.	Chondroitin Sulfates	33-35	protein phosphatase 1 regulatory inhibitor subunit 14B	Homo sapiens	155-159
25906376-3	2015	Because of the dimer repeat, the CS glycosidic "backbone" has two distinct sets of conformational degrees of freedom defined by pairs of dihedral angles: (phi1, psi1) about the beta1-3 glycosidic linkage and (phi2, psi2) about the beta1-4 glycosidic linkage.	Chondroitin Sulfates	33-35	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	177-184
25906376-3	2015	Because of the dimer repeat, the CS glycosidic "backbone" has two distinct sets of conformational degrees of freedom defined by pairs of dihedral angles: (phi1, psi1) about the beta1-3 glycosidic linkage and (phi2, psi2) about the beta1-4 glycosidic linkage.	Chondroitin Sulfates	33-35	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	231-238
25751597-2	2015	PF-ACE-AED approach allowed the possibility to distinguish weak and strong interactions of the binding processes between the most common apolipoprotein E protein isoforms (apoE2, apoE3, apoE4) of high density lipoprotein (HDL) and apoE-containing HDL2 with major glycosaminoglycan (GAG) chain of proteoglycans (PGs), chondroitin-6-sulfate (C6S).	Chondroitin Sulfates	317-338	apolipoprotein E	Homo sapiens	137-153
25751597-2	2015	PF-ACE-AED approach allowed the possibility to distinguish weak and strong interactions of the binding processes between the most common apolipoprotein E protein isoforms (apoE2, apoE3, apoE4) of high density lipoprotein (HDL) and apoE-containing HDL2 with major glycosaminoglycan (GAG) chain of proteoglycans (PGs), chondroitin-6-sulfate (C6S).	Chondroitin Sulfates	317-338	apolipoprotein E	Homo sapiens	172-177
25751597-2	2015	PF-ACE-AED approach allowed the possibility to distinguish weak and strong interactions of the binding processes between the most common apolipoprotein E protein isoforms (apoE2, apoE3, apoE4) of high density lipoprotein (HDL) and apoE-containing HDL2 with major glycosaminoglycan (GAG) chain of proteoglycans (PGs), chondroitin-6-sulfate (C6S).	Chondroitin Sulfates	317-338	apolipoprotein E	Homo sapiens	172-176
25751597-2	2015	PF-ACE-AED approach allowed the possibility to distinguish weak and strong interactions of the binding processes between the most common apolipoprotein E protein isoforms (apoE2, apoE3, apoE4) of high density lipoprotein (HDL) and apoE-containing HDL2 with major glycosaminoglycan (GAG) chain of proteoglycans (PGs), chondroitin-6-sulfate (C6S).	Chondroitin Sulfates	340-343	apolipoprotein E	Homo sapiens	137-153
25751597-2	2015	PF-ACE-AED approach allowed the possibility to distinguish weak and strong interactions of the binding processes between the most common apolipoprotein E protein isoforms (apoE2, apoE3, apoE4) of high density lipoprotein (HDL) and apoE-containing HDL2 with major glycosaminoglycan (GAG) chain of proteoglycans (PGs), chondroitin-6-sulfate (C6S).	Chondroitin Sulfates	340-343	apolipoprotein E	Homo sapiens	172-177
25751597-2	2015	PF-ACE-AED approach allowed the possibility to distinguish weak and strong interactions of the binding processes between the most common apolipoprotein E protein isoforms (apoE2, apoE3, apoE4) of high density lipoprotein (HDL) and apoE-containing HDL2 with major glycosaminoglycan (GAG) chain of proteoglycans (PGs), chondroitin-6-sulfate (C6S).	Chondroitin Sulfates	340-343	apolipoprotein E	Homo sapiens	172-176
25772620-0	2015	Amino acid sequence surrounding the chondroitin sulfate attachment site of thrombomodulin regulates chondroitin polymerization.	Chondroitin Sulfates	36-55	thrombomodulin	Homo sapiens	75-89
25662098-8	2015	Binding experiments and chondroitinase treatment confirmed low affinity binding to chondroitin sulphate chains on cells lacking both M-CSFR and RPTPbeta/zeta.	Chondroitin Sulfates	83-103	colony stimulating factor 1 receptor	Homo sapiens	135-139
25662098-8	2015	Binding experiments and chondroitinase treatment confirmed low affinity binding to chondroitin sulphate chains on cells lacking both M-CSFR and RPTPbeta/zeta.	Chondroitin Sulfates	83-103	protein tyrosine phosphatase receptor type Z1	Homo sapiens	144-152
25662098-9	2015	Amongst the proteoglycans with chondroitin sulphate chains, syndecan-1 was able to modulate the IL-34-induced M-CSFR signalling pathways.	Chondroitin Sulfates	31-51	syndecan 1	Homo sapiens	60-70
25662098-12	2015	This paper provides evidence of alternative binding of IL-34 to chondroitin sulphates and syndecan-1 at the cell surface that modulates M-CSFR activation.	Chondroitin Sulfates	64-85	interleukin 34	Homo sapiens	55-60
25662098-12	2015	This paper provides evidence of alternative binding of IL-34 to chondroitin sulphates and syndecan-1 at the cell surface that modulates M-CSFR activation.	Chondroitin Sulfates	64-85	colony stimulating factor 1 receptor	Homo sapiens	138-142
25898123-2	2015	Binding is mediated by VAR2CSA, a parasite antigen coded by the var gene, which interacts with chondroitin sulfate A (CSA).	Chondroitin Sulfates	95-116	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	27-30
25703627-3	2015	DS-epi1 and D4ST1 are crucial for biosynthesis of dermatan sulfate (DS) moieties in the hybrid chondroitin sulfate (CS)/DS glycosaminoglycans (GAGs).	Chondroitin Sulfates	95-114	dermatan sulfate epimerase	Homo sapiens	0-7
25703627-3	2015	DS-epi1 and D4ST1 are crucial for biosynthesis of dermatan sulfate (DS) moieties in the hybrid chondroitin sulfate (CS)/DS glycosaminoglycans (GAGs).	Chondroitin Sulfates	95-114	carbohydrate sulfotransferase 14	Homo sapiens	12-17
25703627-3	2015	DS-epi1 and D4ST1 are crucial for biosynthesis of dermatan sulfate (DS) moieties in the hybrid chondroitin sulfate (CS)/DS glycosaminoglycans (GAGs).	Chondroitin Sulfates	116-118	dermatan sulfate epimerase	Homo sapiens	0-7
25703627-3	2015	DS-epi1 and D4ST1 are crucial for biosynthesis of dermatan sulfate (DS) moieties in the hybrid chondroitin sulfate (CS)/DS glycosaminoglycans (GAGs).	Chondroitin Sulfates	116-118	carbohydrate sulfotransferase 14	Homo sapiens	12-17
26137222-3	2015	Endocan is secreted into the blood as the soluble proteoglycan, which is the form in the presence of chondroitin sulfate.	Chondroitin Sulfates	101-120	endothelial cell specific molecule 1	Homo sapiens	0-7
25471597-3	2015	We found that an antibody against mouse CD79b profoundly blocks B-cell proliferation induced via the B-cell receptor, CD40, CD180, and chondroitin sulfate, but not via TLR4 or TLR9.	Chondroitin Sulfates	135-154	CD79B antigen	Mus musculus	40-45
25100662-1	2015	Bone morphology protein-2 (BMP-2) encapsulated chitosan/chondrotin sulfate nanoparticles (CHI/CS NPs) are developed to enhance ectopic bone formation on biphasic calcium phosphate (BCP) scaffolds.	Chondroitin Sulfates	56-74	bone morphogenetic protein 2	Oryctolagus cuniculus	27-32
25807054-4	2015	We found that chondroitin sulfate N-acetylgalactosaminyltransferase-2 (CSGalNAcT2), a typical type II transmembrane protein located in Golgi apparatus, could interact with VP2, and we confirmed this interaction by co-immunoprecipitation and confocal laser scanning microscopy assays.	Chondroitin Sulfates	14-33	chondroitin sulfate N-acetylgalactosaminyltransferase 2	Homo sapiens	71-81
25511584-2	2015	ARSB controls the degradation of chondroitin 4-sulfate (C4S) by removing the 4-sulfate group at the non-reducing end of the C4S chain, but has not previously been shown to affect C4S biosynthesis.	Chondroitin Sulfates	33-54	arylsulfatase B	Homo sapiens	0-4
25511584-2	2015	ARSB controls the degradation of chondroitin 4-sulfate (C4S) by removing the 4-sulfate group at the non-reducing end of the C4S chain, but has not previously been shown to affect C4S biosynthesis.	Chondroitin Sulfates	56-59	arylsulfatase B	Homo sapiens	0-4
25511584-2	2015	ARSB controls the degradation of chondroitin 4-sulfate (C4S) by removing the 4-sulfate group at the non-reducing end of the C4S chain, but has not previously been shown to affect C4S biosynthesis.	Chondroitin Sulfates	124-127	arylsulfatase B	Homo sapiens	0-4
25511584-2	2015	ARSB controls the degradation of chondroitin 4-sulfate (C4S) by removing the 4-sulfate group at the non-reducing end of the C4S chain, but has not previously been shown to affect C4S biosynthesis.	Chondroitin Sulfates	124-127	arylsulfatase B	Homo sapiens	0-4
25586191-1	2015	Our previously published data link P-selectin-reactive chondroitin sulfate structures on the surface of breast cancer cells to metastatic behavior of cells.	Chondroitin Sulfates	55-74	selectin P	Homo sapiens	35-45
25534363-8	2015	RESULTS: NCCM (10 &amp; 100%), CS (10 and 100 mug) and Noggin (10 and 100 ng) significantly decreased cell invasion of HUVECs with and without TNFalpha.	Chondroitin Sulfates	31-33	tumor necrosis factor	Homo sapiens	143-151
25534363-9	2015	NCCM 10% and Noggin 10 ng inhibited tubular formation with and without TNFalpha and CS 100 mug inhibited tubules in Basal conditions whereas CS 10 mug inhibited tubules with TNFalpha.	Chondroitin Sulfates	141-143	tumor necrosis factor	Homo sapiens	174-182
25770829-10	2015	Strikingly, both KS-digestion/rehabilitation and CS-digestion/rehabilitation showed significant increases in neurite growth in vivo as estimated by 5-hydroxytryptamine and GAP43 staining.	Chondroitin Sulfates	49-51	growth associated protein 43	Rattus norvegicus	172-177
25561734-2	2015	We propose that either the sulfate groups (or the sulfation pattern) at the reducing end of the chondroitin sulfate (CS) chain of bikunin, or the core protein itself, enables the bikunin proteoglycan (PG) to accept more than a single HC and permits TSG-6 to transfer these HCs from its relatively small CS chain to HA.	Chondroitin Sulfates	96-115	alpha-1-microglobulin/bikunin precursor	Homo sapiens	130-137
25561734-2	2015	We propose that either the sulfate groups (or the sulfation pattern) at the reducing end of the chondroitin sulfate (CS) chain of bikunin, or the core protein itself, enables the bikunin proteoglycan (PG) to accept more than a single HC and permits TSG-6 to transfer these HCs from its relatively small CS chain to HA.	Chondroitin Sulfates	96-115	alpha-1-microglobulin/bikunin precursor	Homo sapiens	179-186
25561734-2	2015	We propose that either the sulfate groups (or the sulfation pattern) at the reducing end of the chondroitin sulfate (CS) chain of bikunin, or the core protein itself, enables the bikunin proteoglycan (PG) to accept more than a single HC and permits TSG-6 to transfer these HCs from its relatively small CS chain to HA.	Chondroitin Sulfates	117-119	alpha-1-microglobulin/bikunin precursor	Homo sapiens	130-137
25561734-2	2015	We propose that either the sulfate groups (or the sulfation pattern) at the reducing end of the chondroitin sulfate (CS) chain of bikunin, or the core protein itself, enables the bikunin proteoglycan (PG) to accept more than a single HC and permits TSG-6 to transfer these HCs from its relatively small CS chain to HA.	Chondroitin Sulfates	117-119	alpha-1-microglobulin/bikunin precursor	Homo sapiens	179-186
25561734-2	2015	We propose that either the sulfate groups (or the sulfation pattern) at the reducing end of the chondroitin sulfate (CS) chain of bikunin, or the core protein itself, enables the bikunin proteoglycan (PG) to accept more than a single HC and permits TSG-6 to transfer these HCs from its relatively small CS chain to HA.	Chondroitin Sulfates	117-119	TNF alpha induced protein 6	Homo sapiens	249-254
25561734-2	2015	We propose that either the sulfate groups (or the sulfation pattern) at the reducing end of the chondroitin sulfate (CS) chain of bikunin, or the core protein itself, enables the bikunin proteoglycan (PG) to accept more than a single HC and permits TSG-6 to transfer these HCs from its relatively small CS chain to HA.	Chondroitin Sulfates	303-305	alpha-1-microglobulin/bikunin precursor	Homo sapiens	130-137
25561734-2	2015	We propose that either the sulfate groups (or the sulfation pattern) at the reducing end of the chondroitin sulfate (CS) chain of bikunin, or the core protein itself, enables the bikunin proteoglycan (PG) to accept more than a single HC and permits TSG-6 to transfer these HCs from its relatively small CS chain to HA.	Chondroitin Sulfates	303-305	alpha-1-microglobulin/bikunin precursor	Homo sapiens	179-186
25561734-3	2015	To test these hypotheses, we investigated HC transfer to the intact CS chain of the bikunin PG, and to the free chain of bikunin.	Chondroitin Sulfates	68-70	alpha-1-microglobulin/bikunin precursor	Homo sapiens	84-91
25561734-4	2015	We observed that both the free CS chain and the intact bikunin PG were only able to accept a single HC from inter-alpha-inhibitor via transfer by TSG-6 and that HCs could be swapped from the bikunin PG and its free CS chain to HA.	Chondroitin Sulfates	31-33	TNF alpha induced protein 6	Homo sapiens	146-151
25561734-4	2015	We observed that both the free CS chain and the intact bikunin PG were only able to accept a single HC from inter-alpha-inhibitor via transfer by TSG-6 and that HCs could be swapped from the bikunin PG and its free CS chain to HA.	Chondroitin Sulfates	215-217	alpha-1-microglobulin/bikunin precursor	Homo sapiens	55-62
25561734-7	2015	In summary, these data demonstrate that the sulfation of the CS chain of bikunin and/or its core protein promote HC transfer by TSG-6 to its relatively short CS chain, although they are insufficient to enable the CS chain of bikunin to accept more than one HC in the absence of other cofactors.	Chondroitin Sulfates	61-63	alpha-1-microglobulin/bikunin precursor	Homo sapiens	73-80
25561734-7	2015	In summary, these data demonstrate that the sulfation of the CS chain of bikunin and/or its core protein promote HC transfer by TSG-6 to its relatively short CS chain, although they are insufficient to enable the CS chain of bikunin to accept more than one HC in the absence of other cofactors.	Chondroitin Sulfates	61-63	TNF alpha induced protein 6	Homo sapiens	128-133
25561734-7	2015	In summary, these data demonstrate that the sulfation of the CS chain of bikunin and/or its core protein promote HC transfer by TSG-6 to its relatively short CS chain, although they are insufficient to enable the CS chain of bikunin to accept more than one HC in the absence of other cofactors.	Chondroitin Sulfates	158-160	alpha-1-microglobulin/bikunin precursor	Homo sapiens	73-80
25561734-7	2015	In summary, these data demonstrate that the sulfation of the CS chain of bikunin and/or its core protein promote HC transfer by TSG-6 to its relatively short CS chain, although they are insufficient to enable the CS chain of bikunin to accept more than one HC in the absence of other cofactors.	Chondroitin Sulfates	158-160	alpha-1-microglobulin/bikunin precursor	Homo sapiens	73-80
25575808-3	2015	We functionally characterize mouse endocan which is also a chondroitin sulfate proteoglycan but much less glycanated than human endocan.	Chondroitin Sulfates	59-78	endothelial cell specific molecule 1	Homo sapiens	35-42
25644401-1	2015	BACKGROUND: Receptor protein tyrosine phosphatase beta/zeta (RPTPbeta/zeta) is a chondroitin sulphate (CS) transmembrane protein tyrosine phosphatase and is a receptor for pleiotrophin (PTN).	Chondroitin Sulfates	81-101	protein tyrosine phosphatase receptor type Z1	Homo sapiens	61-69
25644401-1	2015	BACKGROUND: Receptor protein tyrosine phosphatase beta/zeta (RPTPbeta/zeta) is a chondroitin sulphate (CS) transmembrane protein tyrosine phosphatase and is a receptor for pleiotrophin (PTN).	Chondroitin Sulfates	81-101	pleiotrophin	Homo sapiens	172-184
25644401-1	2015	BACKGROUND: Receptor protein tyrosine phosphatase beta/zeta (RPTPbeta/zeta) is a chondroitin sulphate (CS) transmembrane protein tyrosine phosphatase and is a receptor for pleiotrophin (PTN).	Chondroitin Sulfates	81-101	pleiotrophin	Homo sapiens	186-189
25644401-1	2015	BACKGROUND: Receptor protein tyrosine phosphatase beta/zeta (RPTPbeta/zeta) is a chondroitin sulphate (CS) transmembrane protein tyrosine phosphatase and is a receptor for pleiotrophin (PTN).	Chondroitin Sulfates	103-105	protein tyrosine phosphatase receptor type Z1	Homo sapiens	61-69
25644401-1	2015	BACKGROUND: Receptor protein tyrosine phosphatase beta/zeta (RPTPbeta/zeta) is a chondroitin sulphate (CS) transmembrane protein tyrosine phosphatase and is a receptor for pleiotrophin (PTN).	Chondroitin Sulfates	103-105	pleiotrophin	Homo sapiens	172-184
25644401-1	2015	BACKGROUND: Receptor protein tyrosine phosphatase beta/zeta (RPTPbeta/zeta) is a chondroitin sulphate (CS) transmembrane protein tyrosine phosphatase and is a receptor for pleiotrophin (PTN).	Chondroitin Sulfates	103-105	pleiotrophin	Homo sapiens	186-189
25639594-3	2015	Chondroitin sulfate proteoglycans present in the cardiac scar after MI prevent sympathetic reinnervation by binding the neuronal protein tyrosine phosphatase receptor sigma (PTPsigma).	Chondroitin Sulfates	0-19	protein tyrosine phosphatase receptor type S	Homo sapiens	174-182
25534363-9	2015	NCCM 10% and Noggin 10 ng inhibited tubular formation with and without TNFalpha and CS 100 mug inhibited tubules in Basal conditions whereas CS 10 mug inhibited tubules with TNFalpha.	Chondroitin Sulfates	84-86	noggin	Homo sapiens	13-19
25438961-2	2015	Preparation of nerve allografts involves several steps of decellularization and modification of extracellular matrix to remove chondroitin sulfate proteoglycans (CSPGs), which have been shown to inhibit neurite outgrowth through a poorly understood mechanism involving RhoA and extracellular matrix-integrin interactions.	Chondroitin Sulfates	127-146	ras homolog family member A	Homo sapiens	269-273
25445787-0	2015	Role for chondroitin sulfate glycosaminoglycan in NEDD9-mediated breast cancer cell growth.	Chondroitin Sulfates	9-28	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	50-55
25342714-5	2015	The findings suggest that although all HIT antibodies recognize PF4 in a complex with heparin, only a subset of these antibodies recognize more subtle epitopes induced in PF4 when it binds to CS, the major platelet glycosaminoglycan.	Chondroitin Sulfates	192-194	platelet factor 4	Homo sapiens	171-174
28694940-0	2015	Tailored chondroitin sulfate glycomimetics via a tunable multivalent scaffold for potentiating NGF/TrkA-induced neurogenesis.	Chondroitin Sulfates	9-28	nerve growth factor	Rattus norvegicus	95-98
28694940-0	2015	Tailored chondroitin sulfate glycomimetics via a tunable multivalent scaffold for potentiating NGF/TrkA-induced neurogenesis.	Chondroitin Sulfates	9-28	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	99-103
25624096-3	2015	MB-NSi-p53-CS ternary complexes displayed nanosized diameter, effective p53 condensation ability, efficient p53 protection profile, and superior bovine serum albumin stability in vitro.	Chondroitin Sulfates	11-13	tumor protein p53	Homo sapiens	7-10
25591767-12	2015	Finally, in PCNs, miR-133b also increased axon growth and attenuated axon growth restrictions from chondroitin sulfate proteoglycans (CSPG).	Chondroitin Sulfates	99-118	microRNA 133b	Rattus norvegicus	18-26
25624096-3	2015	MB-NSi-p53-CS ternary complexes displayed nanosized diameter, effective p53 condensation ability, efficient p53 protection profile, and superior bovine serum albumin stability in vitro.	Chondroitin Sulfates	11-13	tumor protein p53	Homo sapiens	72-75
25624096-3	2015	MB-NSi-p53-CS ternary complexes displayed nanosized diameter, effective p53 condensation ability, efficient p53 protection profile, and superior bovine serum albumin stability in vitro.	Chondroitin Sulfates	11-13	tumor protein p53	Homo sapiens	72-75
25578972-7	2014	Immunolabeling for chondroitin sulfate (CS) and biglycan (BGN) was weaker in dentin from DGI-I-affected patients compared to normal dentin, this decrease being significant only for CS.	Chondroitin Sulfates	181-183	biglycan	Homo sapiens	58-61
25325969-3	2015	The HABP probe is prepared by enzymatic digestion of the chondroitin sulfate proteoglycan aggrecan which is present in bovine nasal cartilage, and is then biotinylated in the presence of bound hyaluronan and the link protein.	Chondroitin Sulfates	57-76	hyaluronan binding protein 2	Homo sapiens	4-8
25496828-2	2015	A reduction in or absence of effective GALNS leads to faulty catabolism of keratan sulfate and chondroitin-6-sulfate within the lysosome; their accumulation causes cell, tissue, and organ dysfunction.	Chondroitin Sulfates	95-116	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	39-44
26914753-1	2014	Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads.	Chondroitin Sulfates	50-69	aggrecan	Homo sapiens	0-8
25113670-4	2014	For the first time, we report that SOD1 rats have an abnormal disorganized PNN structure around the spinal motoneurons and give different expression profiles of chondroitin sulfate proteoglycans (CSPGs), such as versican, aggrecan, and phosphacan, but not link protein-1.	Chondroitin Sulfates	161-180	superoxide dismutase 1	Rattus norvegicus	35-39
25113670-4	2014	For the first time, we report that SOD1 rats have an abnormal disorganized PNN structure around the spinal motoneurons and give different expression profiles of chondroitin sulfate proteoglycans (CSPGs), such as versican, aggrecan, and phosphacan, but not link protein-1.	Chondroitin Sulfates	161-180	versican	Rattus norvegicus	212-220
25287660-3	2014	Tertiary GALNS structure was modeled and used for molecular docking against galactose-6-sulfate, N-acetylgalactosamine-6-sulfate, keratan sulfate, chondroitin-6-sulfate, and the artificial substrate 4-methylumbelliferyl-beta-D-galactopyranoside-6-sulfate.	Chondroitin Sulfates	147-168	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	9-14
25290812-4	2014	In terms of suppression of gene expression in vivo, apolipoprotein B (ApoB) mRNA in the liver and low-density-lipoprotein (LDL) and very low-density-lipoprotein (VLDL) cholesterol level in serum were reduced at 48 h after single sequential injection of PGA or CS plus cationic lipoplex of cholesterol-modified ApoB siRNA.	Chondroitin Sulfates	260-262	apolipoprotein B	Homo sapiens	52-68
25290812-4	2014	In terms of suppression of gene expression in vivo, apolipoprotein B (ApoB) mRNA in the liver and low-density-lipoprotein (LDL) and very low-density-lipoprotein (VLDL) cholesterol level in serum were reduced at 48 h after single sequential injection of PGA or CS plus cationic lipoplex of cholesterol-modified ApoB siRNA.	Chondroitin Sulfates	260-262	apolipoprotein B	Homo sapiens	70-74
24240681-1	2014	Arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB) removes 4-sulfate groups from chondroitin-4-sulfate (C4S) and dermatan sulfate and is required for their degradation.	Chondroitin Sulfates	88-109	arylsulfatase B	Homo sapiens	0-15
24240681-1	2014	Arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB) removes 4-sulfate groups from chondroitin-4-sulfate (C4S) and dermatan sulfate and is required for their degradation.	Chondroitin Sulfates	88-109	arylsulfatase B	Homo sapiens	17-50
24240681-1	2014	Arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB) removes 4-sulfate groups from chondroitin-4-sulfate (C4S) and dermatan sulfate and is required for their degradation.	Chondroitin Sulfates	88-109	arylsulfatase B	Homo sapiens	52-56
24240681-1	2014	Arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB) removes 4-sulfate groups from chondroitin-4-sulfate (C4S) and dermatan sulfate and is required for their degradation.	Chondroitin Sulfates	111-114	arylsulfatase B	Homo sapiens	0-15
24240681-1	2014	Arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB) removes 4-sulfate groups from chondroitin-4-sulfate (C4S) and dermatan sulfate and is required for their degradation.	Chondroitin Sulfates	111-114	arylsulfatase B	Homo sapiens	17-50
24240681-1	2014	Arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB) removes 4-sulfate groups from chondroitin-4-sulfate (C4S) and dermatan sulfate and is required for their degradation.	Chondroitin Sulfates	111-114	arylsulfatase B	Homo sapiens	52-56
25331352-0	2014	Gelatin-chondroitin-6-sulfate-hyaluronic acid scaffold seeded with vascular endothelial growth factor 165 modified hair follicle stem cells as a three-dimensional skin substitute.	Chondroitin Sulfates	8-29	vascular endothelial growth factor A	Rattus norvegicus	67-101
25176127-3	2014	Here, we report that heparan sulfate (HS) and chondroitin sulfate E (CSE) selectively regulate postsecretory trafficking of TIMP-3 by inhibiting its binding to LRP-1.	Chondroitin Sulfates	46-65	TIMP metallopeptidase inhibitor 3	Homo sapiens	124-130
25176127-3	2014	Here, we report that heparan sulfate (HS) and chondroitin sulfate E (CSE) selectively regulate postsecretory trafficking of TIMP-3 by inhibiting its binding to LRP-1.	Chondroitin Sulfates	46-65	LDL receptor related protein 1	Homo sapiens	160-165
24716865-4	2014	CS-C immunoreactivity, which represents chondroitin sulfate moieties, was significantly attenuated in the stab-injured cortices of OASIS knockout mice compared to those of wild-type mice.	Chondroitin Sulfates	40-59	cAMP responsive element binding protein 3-like 1	Mus musculus	131-136
25122765-5	2014	Site-directed mutagenesis identified the N-terminal CS attachment sites Ser(507) and Ser(525) as essential for processing of the Glu(441)-Ala(442) bond by ADAMTS5.	Chondroitin Sulfates	52-54	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	155-162
25122765-7	2014	Therefore, CS chain attachment to Ser(507) and Ser(525) is necessary and sufficient for versican proteolysis by ADAMTS5.	Chondroitin Sulfates	11-13	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	112-119
25122765-9	2014	ADAMTS5 lacking the C-terminal ancillary domain did not cleave versican, and an ADAMTS5 ancillary domain construct bound versican-V1 via the CS chains.	Chondroitin Sulfates	141-143	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	80-87
25261974-9	2014	In a dose-dependent manner, CS significantly inhibited IL-1beta (p = 0.003), and TNFalpha (p = 0.02) production from macrophages in response to MSU.	Chondroitin Sulfates	28-30	interleukin 1 beta	Homo sapiens	55-63
25261974-9	2014	In a dose-dependent manner, CS significantly inhibited IL-1beta (p = 0.003), and TNFalpha (p = 0.02) production from macrophages in response to MSU.	Chondroitin Sulfates	28-30	tumor necrosis factor	Homo sapiens	81-89
24508597-2	2014	The enzymes N-acetylgalactosamine-4-sulfatase (arylsulfatase B; ARSB) and N-acetylgalactosamine-6-sulfatase (GALNS), which remove sulfate groups from the sulfated GAGs chondroitin 4-sulfate (C4S) and chondroitin 6-sulfate, respectively, have not been studied in prostate development previously.	Chondroitin Sulfates	168-189	arylsulfatase B	Rattus norvegicus	64-68
24508597-2	2014	The enzymes N-acetylgalactosamine-4-sulfatase (arylsulfatase B; ARSB) and N-acetylgalactosamine-6-sulfatase (GALNS), which remove sulfate groups from the sulfated GAGs chondroitin 4-sulfate (C4S) and chondroitin 6-sulfate, respectively, have not been studied in prostate development previously.	Chondroitin Sulfates	168-189	galactosamine (N-acetyl)-6-sulfatase	Rattus norvegicus	109-114
24508597-2	2014	The enzymes N-acetylgalactosamine-4-sulfatase (arylsulfatase B; ARSB) and N-acetylgalactosamine-6-sulfatase (GALNS), which remove sulfate groups from the sulfated GAGs chondroitin 4-sulfate (C4S) and chondroitin 6-sulfate, respectively, have not been studied in prostate development previously.	Chondroitin Sulfates	191-194	arylsulfatase B	Rattus norvegicus	64-68
24508597-2	2014	The enzymes N-acetylgalactosamine-4-sulfatase (arylsulfatase B; ARSB) and N-acetylgalactosamine-6-sulfatase (GALNS), which remove sulfate groups from the sulfated GAGs chondroitin 4-sulfate (C4S) and chondroitin 6-sulfate, respectively, have not been studied in prostate development previously.	Chondroitin Sulfates	191-194	galactosamine (N-acetyl)-6-sulfatase	Rattus norvegicus	109-114
24508597-2	2014	The enzymes N-acetylgalactosamine-4-sulfatase (arylsulfatase B; ARSB) and N-acetylgalactosamine-6-sulfatase (GALNS), which remove sulfate groups from the sulfated GAGs chondroitin 4-sulfate (C4S) and chondroitin 6-sulfate, respectively, have not been studied in prostate development previously.	Chondroitin Sulfates	200-221	arylsulfatase B	Rattus norvegicus	64-68
24508597-2	2014	The enzymes N-acetylgalactosamine-4-sulfatase (arylsulfatase B; ARSB) and N-acetylgalactosamine-6-sulfatase (GALNS), which remove sulfate groups from the sulfated GAGs chondroitin 4-sulfate (C4S) and chondroitin 6-sulfate, respectively, have not been studied in prostate development previously.	Chondroitin Sulfates	200-221	galactosamine (N-acetyl)-6-sulfatase	Rattus norvegicus	109-114
24508597-3	2014	In this report, the endogenous variation and the impact of exogenous estradiol benzoate on the immunohistochemistry and activity of ARSB and GALNS in post-natal (days 1-30) ventral rat prostate are presented, as well as measurements of steroid sulfatase activity (STS), C4S, total sulfated GAGs, and versican, an extracellular matrix proteoglycan with chondroitin sulfate attachments on days 5 and 30.	Chondroitin Sulfates	352-371	arylsulfatase B	Rattus norvegicus	132-136
24955618-8	2014	DISCUSSION: SLNs enhanced accumulation at the knee joint due to specific interactions with CD44, annexin and leptin receptors attributed to CS coupling.	Chondroitin Sulfates	140-142	CD44 molecule (Indian blood group)	Homo sapiens	91-95
25227175-3	2014	The receptor molecule for the CS chains containing E-disaccharide units (CS-E) expressed on Lewis lung carcinoma (LLC) cells was recently revealed to be Receptor for Advanced Glycation End-products (RAGE).	Chondroitin Sulfates	30-32	cystathionase (cystathionine gamma-lyase)	Mus musculus	73-77
24792783-15	2014	Conversely, CS exposure decreased MAP2, betaIII tubulin, and NGF expressions.	Chondroitin Sulfates	12-14	microtubule associated protein 2	Homo sapiens	34-38
24792783-15	2014	Conversely, CS exposure decreased MAP2, betaIII tubulin, and NGF expressions.	Chondroitin Sulfates	12-14	nerve growth factor	Homo sapiens	61-64
24716865-12	2014	We found that the up-regulated OASIS is involved in the transcriptional regulation of C6ST1 gene, which promotes chondroitin sulfate proteoglycan (CSPG) sulfation.	Chondroitin Sulfates	113-132	cAMP responsive element binding protein 3-like 1	Mus musculus	31-36
24716865-12	2014	We found that the up-regulated OASIS is involved in the transcriptional regulation of C6ST1 gene, which promotes chondroitin sulfate proteoglycan (CSPG) sulfation.	Chondroitin Sulfates	113-132	carbohydrate sulfotransferase 3	Mus musculus	86-91
24768589-1	2014	Matrix metalloproteinase-12 (MMP-12; macrophage metalloelastase) degrades a number of extracellular matrix components which are present in the intervertebral disc, including type IV collagen, fibronectin, laminin, chondroitin sulfates, elastin and fibrinogen.	Chondroitin Sulfates	214-234	matrix metallopeptidase 12	Rattus norvegicus	0-27
24412194-3	2014	SCOPE OF REVIEW: The existing knowledge on glycosylation by CS (CS glycanation) of cell membrane proteins and receptors, such as syndecans, chondroitin sulfate proteoglycan 4, betaglycan, neuropilin-1, integrins and receptor protein tyrosine phosphatase beta/zeta, is summarized and the importance of CS glycanation in growth factor-induced migration, angiogenesis and tumor growth and invasion is described.	Chondroitin Sulfates	60-62	transforming growth factor beta receptor 3	Homo sapiens	176-186
24412194-3	2014	SCOPE OF REVIEW: The existing knowledge on glycosylation by CS (CS glycanation) of cell membrane proteins and receptors, such as syndecans, chondroitin sulfate proteoglycan 4, betaglycan, neuropilin-1, integrins and receptor protein tyrosine phosphatase beta/zeta, is summarized and the importance of CS glycanation in growth factor-induced migration, angiogenesis and tumor growth and invasion is described.	Chondroitin Sulfates	60-62	neuropilin 1	Homo sapiens	188-224
24412194-3	2014	SCOPE OF REVIEW: The existing knowledge on glycosylation by CS (CS glycanation) of cell membrane proteins and receptors, such as syndecans, chondroitin sulfate proteoglycan 4, betaglycan, neuropilin-1, integrins and receptor protein tyrosine phosphatase beta/zeta, is summarized and the importance of CS glycanation in growth factor-induced migration, angiogenesis and tumor growth and invasion is described.	Chondroitin Sulfates	64-66	transforming growth factor beta receptor 3	Homo sapiens	176-186
24412194-3	2014	SCOPE OF REVIEW: The existing knowledge on glycosylation by CS (CS glycanation) of cell membrane proteins and receptors, such as syndecans, chondroitin sulfate proteoglycan 4, betaglycan, neuropilin-1, integrins and receptor protein tyrosine phosphatase beta/zeta, is summarized and the importance of CS glycanation in growth factor-induced migration, angiogenesis and tumor growth and invasion is described.	Chondroitin Sulfates	64-66	neuropilin 1	Homo sapiens	188-224
24412194-3	2014	SCOPE OF REVIEW: The existing knowledge on glycosylation by CS (CS glycanation) of cell membrane proteins and receptors, such as syndecans, chondroitin sulfate proteoglycan 4, betaglycan, neuropilin-1, integrins and receptor protein tyrosine phosphatase beta/zeta, is summarized and the importance of CS glycanation in growth factor-induced migration, angiogenesis and tumor growth and invasion is described.	Chondroitin Sulfates	64-66	transforming growth factor beta receptor 3	Homo sapiens	176-186
24412194-3	2014	SCOPE OF REVIEW: The existing knowledge on glycosylation by CS (CS glycanation) of cell membrane proteins and receptors, such as syndecans, chondroitin sulfate proteoglycan 4, betaglycan, neuropilin-1, integrins and receptor protein tyrosine phosphatase beta/zeta, is summarized and the importance of CS glycanation in growth factor-induced migration, angiogenesis and tumor growth and invasion is described.	Chondroitin Sulfates	64-66	neuropilin 1	Homo sapiens	188-224
24768589-1	2014	Matrix metalloproteinase-12 (MMP-12; macrophage metalloelastase) degrades a number of extracellular matrix components which are present in the intervertebral disc, including type IV collagen, fibronectin, laminin, chondroitin sulfates, elastin and fibrinogen.	Chondroitin Sulfates	214-234	matrix metallopeptidase 12	Rattus norvegicus	29-35
24768589-1	2014	Matrix metalloproteinase-12 (MMP-12; macrophage metalloelastase) degrades a number of extracellular matrix components which are present in the intervertebral disc, including type IV collagen, fibronectin, laminin, chondroitin sulfates, elastin and fibrinogen.	Chondroitin Sulfates	214-234	matrix metallopeptidase 12	Rattus norvegicus	37-63
24958728-4	2014	We have demonstrated that chondroitin 4-sulfate (C4-S) promotes autoprocessing of the pro-domain of CatK at pH &lt;= 5, leading to a fully matured enzyme with collagenase and peptidase activities.	Chondroitin Sulfates	26-47	cathepsin K	Homo sapiens	100-104
24958728-4	2014	We have demonstrated that chondroitin 4-sulfate (C4-S) promotes autoprocessing of the pro-domain of CatK at pH &lt;= 5, leading to a fully matured enzyme with collagenase and peptidase activities.	Chondroitin Sulfates	49-53	cathepsin K	Homo sapiens	100-104
24958728-6	2014	During bone resorption, CatK and C4-S are co-localized at the ruffled border between osteoclast bone interface, supporting the proposal that CatK activation is accomplished through the combined action of the acidic environment together with the presence of a high concentration of C4-S.	Chondroitin Sulfates	33-37	cathepsin K	Homo sapiens	141-145
24958728-6	2014	During bone resorption, CatK and C4-S are co-localized at the ruffled border between osteoclast bone interface, supporting the proposal that CatK activation is accomplished through the combined action of the acidic environment together with the presence of a high concentration of C4-S.	Chondroitin Sulfates	281-285	cathepsin K	Homo sapiens	24-28
24958728-6	2014	During bone resorption, CatK and C4-S are co-localized at the ruffled border between osteoclast bone interface, supporting the proposal that CatK activation is accomplished through the combined action of the acidic environment together with the presence of a high concentration of C4-S.	Chondroitin Sulfates	281-285	cathepsin K	Homo sapiens	141-145
24958728-7	2014	Formation of a multimeric complex between C4-S and pro-CatK has been speculated to accelerate CatK autoactivation and promote efficient collagen degradation.	Chondroitin Sulfates	42-46	cathepsin K	Homo sapiens	55-59
24958728-7	2014	Formation of a multimeric complex between C4-S and pro-CatK has been speculated to accelerate CatK autoactivation and promote efficient collagen degradation.	Chondroitin Sulfates	42-46	cathepsin K	Homo sapiens	94-98
24958728-8	2014	Together, these results demonstrate that CS plays an important role in contributing to the enhanced efficiency of CatK collagenase activity in vivo.	Chondroitin Sulfates	41-43	cathepsin K	Homo sapiens	114-118
24927450-4	2014	CS also largely reduced adsorption of bovine serum albumin (BSA) as well as fetal bovine serum (FBS) but to a lower extent than PEG and CMD surfaces (72% vs 85% for BSA and 66% vs 89% for FBS).	Chondroitin Sulfates	0-2	albumin	Homo sapiens	45-58
24583690-8	2014	Under optimal conditions (5 muM coralyne, 1 muM poly A20, and 10mM HEPES), this probe exhibited high selectivity (&gt;90-fold) toward heparin over hyaluronic acid and chondroitin sulfate.	Chondroitin Sulfates	167-186	latexin	Homo sapiens	28-31
24583690-8	2014	Under optimal conditions (5 muM coralyne, 1 muM poly A20, and 10mM HEPES), this probe exhibited high selectivity (&gt;90-fold) toward heparin over hyaluronic acid and chondroitin sulfate.	Chondroitin Sulfates	167-186	latexin	Homo sapiens	44-47
24583690-8	2014	Under optimal conditions (5 muM coralyne, 1 muM poly A20, and 10mM HEPES), this probe exhibited high selectivity (&gt;90-fold) toward heparin over hyaluronic acid and chondroitin sulfate.	Chondroitin Sulfates	167-186	immunoglobulin kappa variable 1-27	Homo sapiens	53-56
24555985-0	2014	Chondroitin sulfate activates B cells in vitro, expands CD138+ cells in vivo, and interferes with established humoral immune responses.	Chondroitin Sulfates	0-19	syndecan 1	Mus musculus	56-61
24778176-0	2014	Increased expression of colonic Wnt9A through Sp1-mediated transcriptional effects involving arylsulfatase B, chondroitin 4-sulfate, and galectin-3.	Chondroitin Sulfates	110-131	Wnt family member 9A	Homo sapiens	32-37
24778176-4	2014	When ARSB activity was reduced by siRNA or by exposure to carrageenan (1 mug/ml for 24 h), degradation of chondroitin 4-sulfate (C4S) was inhibited, leading to accumulation of more highly sulfated C4S, which binds less galectin-3, a beta-galactoside-binding protein.	Chondroitin Sulfates	106-127	arylsulfatase B	Homo sapiens	5-9
24778176-4	2014	When ARSB activity was reduced by siRNA or by exposure to carrageenan (1 mug/ml for 24 h), degradation of chondroitin 4-sulfate (C4S) was inhibited, leading to accumulation of more highly sulfated C4S, which binds less galectin-3, a beta-galactoside-binding protein.	Chondroitin Sulfates	106-127	galectin 3	Homo sapiens	219-229
24778176-4	2014	When ARSB activity was reduced by siRNA or by exposure to carrageenan (1 mug/ml for 24 h), degradation of chondroitin 4-sulfate (C4S) was inhibited, leading to accumulation of more highly sulfated C4S, which binds less galectin-3, a beta-galactoside-binding protein.	Chondroitin Sulfates	129-132	arylsulfatase B	Homo sapiens	5-9
24778176-4	2014	When ARSB activity was reduced by siRNA or by exposure to carrageenan (1 mug/ml for 24 h), degradation of chondroitin 4-sulfate (C4S) was inhibited, leading to accumulation of more highly sulfated C4S, which binds less galectin-3, a beta-galactoside-binding protein.	Chondroitin Sulfates	129-132	galectin 3	Homo sapiens	219-229
24778176-4	2014	When ARSB activity was reduced by siRNA or by exposure to carrageenan (1 mug/ml for 24 h), degradation of chondroitin 4-sulfate (C4S) was inhibited, leading to accumulation of more highly sulfated C4S, which binds less galectin-3, a beta-galactoside-binding protein.	Chondroitin Sulfates	197-200	arylsulfatase B	Homo sapiens	5-9
24958728-0	2014	Chondroitin sulfate promotes activation of cathepsin K.	Chondroitin Sulfates	0-19	cathepsin K	Homo sapiens	43-54
24958728-2	2014	Evidence exists that the collagenase activity of CatK is promoted by chondroitin sulfate (CS), a sulfated glycosaminoglycan.	Chondroitin Sulfates	69-88	cathepsin K	Homo sapiens	49-53
24958728-2	2014	Evidence exists that the collagenase activity of CatK is promoted by chondroitin sulfate (CS), a sulfated glycosaminoglycan.	Chondroitin Sulfates	90-92	cathepsin K	Homo sapiens	49-53
24958728-3	2014	This study examines the role of CS in facilitating CatK activation.	Chondroitin Sulfates	32-34	cathepsin K	Homo sapiens	51-55
25190157-1	2014	OBJECTIVE: Mucopolysaccharidosis type VI (MPS VI) or Maroteaux-Lamy syndrome is an autosomal recessive lysosomal storage disease caused by a deficiency of arylsulfatase B(ARSB), which is required in the degradation of dermatan sulfate and chondroitin sulfate.	Chondroitin Sulfates	239-258	arylsulfatase B	Homo sapiens	171-175
24561712-0	2014	Chondroitin-6-sulfate attenuates inflammatory responses in murine macrophages via suppression of NF-kappaB nuclear translocation.	Chondroitin Sulfates	0-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-106
24561712-8	2014	In addition, the highest magnitude of inhibitory effects was obtained when cells were pre-treated with C6S prior to IFN-gamma/LPS or LPS challenge, suggesting an additional role for C6S in protection against microbial infection.	Chondroitin Sulfates	103-106	interferon gamma	Mus musculus	116-125
24726177-2	2014	Patients who inherit two mutated GALNS gene alleles have a decreased ability to degrade the glycosaminoglycans (GAGs) keratan sulfate and chondroitin 6-sulfate, thereby causing GAG accumulation within lysosomes and consequently pleiotropic disease.	Chondroitin Sulfates	138-159	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	33-38
25190157-2	2014	The deficiency of ARSB leads to an accumulation of dermatan sulfate and chondroitin sulfate in lysosomes and gross excretion in the urine.Few articles about clinical study and ARSB gene mutation analysis of Chinese MPS VI patients were published.	Chondroitin Sulfates	72-91	arylsulfatase B	Homo sapiens	18-22
24530640-6	2014	Our results demonstrate that the major binding sites for RPTPsigma in adult mouse brain are on neurons and are not proteoglycan GAG chains, as RPTPsigma binding overlaps with the neuronal marker NeuN and was not significantly altered by treatments which eliminate chondroitin sulfate, heparan sulfate, or both.	Chondroitin Sulfates	264-283	protein tyrosine phosphatase, receptor type, S	Mus musculus	57-66
25756001-7	2014	In terms of the suppression of gene expression in vivo, apolipoprotein B (ApoB) mRNA in the liver was significantly reduced 48?h after single intravenous injection of PGA-coated lipoplex of ApoB siRNA-Chol (2.5?mg?siRNA/kg), but not cationic, CS- and PAA-coated lipoplexes.	Chondroitin Sulfates	243-245	apolipoprotein B	Mus musculus	56-72
24718687-0	2014	Oversulfated chondroitin sulfate binds to chemokines and inhibits stromal cell-derived factor-1 mediated signaling in activated T cells.	Chondroitin Sulfates	13-32	C-X-C motif chemokine ligand 12	Homo sapiens	66-95
24509075-6	2014	In addition, the heparan sulfate (HS) and chondroitin sulfate (CS) families of PGs interact directly with a number of growth factors, signalling pathways and ECM components including FGFs, Wnts and fibronectin.	Chondroitin Sulfates	42-61	fibronectin 1	Homo sapiens	198-209
24509075-6	2014	In addition, the heparan sulfate (HS) and chondroitin sulfate (CS) families of PGs interact directly with a number of growth factors, signalling pathways and ECM components including FGFs, Wnts and fibronectin.	Chondroitin Sulfates	63-65	fibronectin 1	Homo sapiens	198-209
24667694-0	2014	Biphasic role of chondroitin sulfate in cardiac differentiation of embryonic stem cells through inhibition of Wnt/beta-catenin signaling.	Chondroitin Sulfates	17-36	catenin beta 1	Homo sapiens	114-126
24667694-4	2014	Here, we report a novel biphasic role of chondroitin sulfate in the specification of the cardiac cell lineage during embryonic stem cell differentiation through modulation of Wnt/beta-catenin signaling.	Chondroitin Sulfates	41-60	catenin beta 1	Homo sapiens	179-191
24667694-7	2014	Mechanistically, we show that endogenous chondroitin sulfate controls cardiac differentiation in a temporal biphasic manner through inhibition of the Wnt/beta-catenin pathway, a known regulatory pathway for the cardiac lineage.	Chondroitin Sulfates	41-60	catenin beta 1	Homo sapiens	154-166
24667694-8	2014	Treatment with a specific exogenous chondroitin sulfate, CS-E, could mimic these biphasic effects on cardiac differentiation and Wnt/beta-catenin signaling.	Chondroitin Sulfates	36-55	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	57-61
24667694-8	2014	Treatment with a specific exogenous chondroitin sulfate, CS-E, could mimic these biphasic effects on cardiac differentiation and Wnt/beta-catenin signaling.	Chondroitin Sulfates	36-55	catenin beta 1	Homo sapiens	133-145
24667694-9	2014	These results establish chondroitin sulfate and its sulfation balance as important regulators of cardiac cell lineage decisions through control of the Wnt/beta-catenin pathway.	Chondroitin Sulfates	24-43	catenin beta 1	Homo sapiens	155-167
24372543-0	2014	Positive correlations between hCAP18/LL-37 and chondroitin sulphate levels in chronic periodontitis.	Chondroitin Sulfates	47-67	cathelicidin antimicrobial peptide	Homo sapiens	30-36
24372543-0	2014	Positive correlations between hCAP18/LL-37 and chondroitin sulphate levels in chronic periodontitis.	Chondroitin Sulfates	47-67	cathelicidin antimicrobial peptide	Homo sapiens	37-42
24372543-6	2014	CONCLUSION: The significant correlations between the hCAP18/LL-37 and the CS levels were found in CP, but not in aggressive periodontitis.	Chondroitin Sulfates	74-76	cathelicidin antimicrobial peptide	Homo sapiens	53-59
24372543-6	2014	CONCLUSION: The significant correlations between the hCAP18/LL-37 and the CS levels were found in CP, but not in aggressive periodontitis.	Chondroitin Sulfates	74-76	cathelicidin antimicrobial peptide	Homo sapiens	60-65
24354860-10	2014	In addition, sulfation patterns of chondroitin sulfate (CS) chains in CSPG4 showed dramatic changes between these cell lines.	Chondroitin Sulfates	35-54	chondroitin sulfate proteoglycan 4	Homo sapiens	70-75
24354860-10	2014	In addition, sulfation patterns of chondroitin sulfate (CS) chains in CSPG4 showed dramatic changes between these cell lines.	Chondroitin Sulfates	56-58	chondroitin sulfate proteoglycan 4	Homo sapiens	70-75
24444886-0	2014	Chondroitin sulfate-capped gold nanoparticles for the oral delivery of insulin.	Chondroitin Sulfates	0-19	insulin	Homo sapiens	71-78
25756001-7	2014	In terms of the suppression of gene expression in vivo, apolipoprotein B (ApoB) mRNA in the liver was significantly reduced 48?h after single intravenous injection of PGA-coated lipoplex of ApoB siRNA-Chol (2.5?mg?siRNA/kg), but not cationic, CS- and PAA-coated lipoplexes.	Chondroitin Sulfates	243-245	apolipoprotein B	Mus musculus	74-78
25756001-7	2014	In terms of the suppression of gene expression in vivo, apolipoprotein B (ApoB) mRNA in the liver was significantly reduced 48?h after single intravenous injection of PGA-coated lipoplex of ApoB siRNA-Chol (2.5?mg?siRNA/kg), but not cationic, CS- and PAA-coated lipoplexes.	Chondroitin Sulfates	243-245	apolipoprotein B	Mus musculus	190-194
25413333-0	2014	Chondroitin sulfate microparticles modulate transforming growth factor-beta1-induced chondrogenesis of human mesenchymal stem cell spheroids.	Chondroitin Sulfates	0-19	transforming growth factor beta 1	Homo sapiens	44-76
24424429-7	2014	Collectively, these results suggest that CS is a novel determinant in controlling the functional integrity of ESCs via binding to E-cadherin.	Chondroitin Sulfates	41-43	cadherin 1	Mus musculus	130-140
24850234-3	2014	Mucopolysaccharidosis IVA and VII (MPS IVA and VII) are caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase and beta-D-glucuronidase, respectively, resulting in accumulation of C6S and other GAG(s).	Chondroitin Sulfates	195-198	glucuronidase beta	Homo sapiens	130-150
24055620-1	2013	A rigorous processing of adsorption data from quartz crystal microbalance technology was successfully combined with the data obtained by partial filling affinity capillary electrophoresis and molecular dynamics for the clarification of the temperature effect on the interaction of a major glycosaminoglycan chain chondroitin-6-sulfate (C6S) of proteoglycans with low-density lipoprotein (LDL) and with a peptide fragment of apolipoprotein B-100 (residues 3359-3377 of LDL, PPBS).	Chondroitin Sulfates	313-334	apolipoprotein B	Homo sapiens	424-444
23433350-8	2014	In first and the second moments, latent MMP-2 was significantly elevated in the eyes treated with NAC and CS (P &lt; 0.001).	Chondroitin Sulfates	106-108	matrix metallopeptidase 2	Rattus norvegicus	40-45
23433350-9	2014	Active MMP-2 did not change significantly among treatment groups in the first moment (P &gt; 0.05); significantly higher activity was observed in the second moment in the eyes treated with CS (P &lt;0.001).	Chondroitin Sulfates	189-191	matrix metallopeptidase 2	Rattus norvegicus	7-12
23433350-13	2014	Significant higher levels of active form of MMP-2 in 3% chondroitin sulfate-treated group may indicate that the agent acts as substrate for such enzyme.	Chondroitin Sulfates	56-75	matrix metallopeptidase 2	Rattus norvegicus	44-49
23616370-5	2013	The combination of CS and PDMAEMA is expected not only to reduce the cytotoxicity of PDMAEMA, but also to facilitate better transfection efficiency than PDMAEMA because of the recognition of CS by CD44 receptors on cell surfaces.	Chondroitin Sulfates	19-21	CD44 molecule (Indian blood group)	Homo sapiens	197-201
23616370-5	2013	The combination of CS and PDMAEMA is expected not only to reduce the cytotoxicity of PDMAEMA, but also to facilitate better transfection efficiency than PDMAEMA because of the recognition of CS by CD44 receptors on cell surfaces.	Chondroitin Sulfates	191-193	CD44 molecule (Indian blood group)	Homo sapiens	197-201
24176075-1	2013	ADAMTS-1, -4, -5 and -9 belong to "a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)" family and more precisely to the proteoglycanases subgroup based on their common ability to degrade chondroitin sulfate proteoglycans.	Chondroitin Sulfates	208-227	ADAM metallopeptidase with thrombospondin type 1 motif 1	Homo sapiens	0-23
23889129-1	2013	Chicken acidic leucine-rich EGF-like domain-containing brain protein (CALEB), also known as chondroitin sulfate proteoglycan (CSPG)5 or neuroglycan C, is a neural chondroitin sulfate-containing and epidermal growth factor (EGF)-domain-containing transmembrane protein that is implicated in synaptic maturation.	Chondroitin Sulfates	92-111	chondroitin sulfate proteoglycan 5	Mus musculus	8-68
23889129-1	2013	Chicken acidic leucine-rich EGF-like domain-containing brain protein (CALEB), also known as chondroitin sulfate proteoglycan (CSPG)5 or neuroglycan C, is a neural chondroitin sulfate-containing and epidermal growth factor (EGF)-domain-containing transmembrane protein that is implicated in synaptic maturation.	Chondroitin Sulfates	92-111	chondroitin sulfate proteoglycan 5	Mus musculus	70-75
23889129-1	2013	Chicken acidic leucine-rich EGF-like domain-containing brain protein (CALEB), also known as chondroitin sulfate proteoglycan (CSPG)5 or neuroglycan C, is a neural chondroitin sulfate-containing and epidermal growth factor (EGF)-domain-containing transmembrane protein that is implicated in synaptic maturation.	Chondroitin Sulfates	92-111	chondroitin sulfate proteoglycan 5	Mus musculus	136-149
23889129-10	2013	The alterations observed by patch-clamp recordings correlated with a specific pattern and timing of expression of CALEB in Purkinje cells, i.e. it is dynamically regulated during development from a high chondroitin sulfate-containing form to a non-chondroitin sulfate-containing form.	Chondroitin Sulfates	203-222	chondroitin sulfate proteoglycan 5	Mus musculus	114-119
23889129-10	2013	The alterations observed by patch-clamp recordings correlated with a specific pattern and timing of expression of CALEB in Purkinje cells, i.e. it is dynamically regulated during development from a high chondroitin sulfate-containing form to a non-chondroitin sulfate-containing form.	Chondroitin Sulfates	248-267	chondroitin sulfate proteoglycan 5	Mus musculus	114-119
24061149-0	2013	Fucosylated chondroitin sulfate from Acaudina molpadioides improves hyperglycemia via activation of PKB/GLUT4 signaling in skeletal muscle of insulin resistant mice.	Chondroitin Sulfates	12-31	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	104-109
23999154-5	2013	It has been recently shown that the chemorepulsive axon guidance protein semaphorin3A (Sema3A) is also a constituent of PNNs, binding with high affinity to the sugar chains of chondroitin sulfate proteoglycans.	Chondroitin Sulfates	176-195	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	73-85
23999154-5	2013	It has been recently shown that the chemorepulsive axon guidance protein semaphorin3A (Sema3A) is also a constituent of PNNs, binding with high affinity to the sugar chains of chondroitin sulfate proteoglycans.	Chondroitin Sulfates	176-195	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A	Mus musculus	87-93
25247259-6	2014	Additionally, LMM CS was able to significantly decrease GGT activity by approximately 31% and plasmatic CRP levels by about 9%.	Chondroitin Sulfates	18-20	C-reactive protein	Homo sapiens	104-107
23811343-0	2013	A chondroitin synthase-1 (ChSy-1) missense mutation in a patient with neuropathy impairs the elongation of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1.	Chondroitin Sulfates	107-126	chondroitin sulfate synthase 1	Homo sapiens	2-24
24205138-6	2013	Serglycin was purified from conditioned medium of MDA-MB-231 cells, and represented the major proteoglycan secreted by these cells, having a molecular size of ~ 250 kDa and carrying chondroitin sulfate side chains, mainly composed of 4-sulfated (~ 87%), 6-sulfated (~ 10%) and non-sulfated (~ 3%) disaccharides.	Chondroitin Sulfates	182-201	serglycin	Homo sapiens	0-9
23811343-0	2013	A chondroitin synthase-1 (ChSy-1) missense mutation in a patient with neuropathy impairs the elongation of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1.	Chondroitin Sulfates	107-126	chondroitin sulfate synthase 1	Homo sapiens	26-32
23811343-4	2013	Chondroitin synthase-1 has two glycosyltransferase activities: it acts as a GlcUA and a GalNAc transferase and is responsible for adding repeated disaccharide units to growing chondroitin sulfate chains.	Chondroitin Sulfates	176-195	chondroitin sulfate synthase 1	Homo sapiens	0-22
23811343-9	2013	CONCLUSIONS: The chondroitin synthase-1 F362S mutation in a patient with neuropathy resulted in a decrease in chondroitin polymerization activity and the mutant protein was defective in regulating the number of chondroitin sulfate chains via chondroitin N-acetylgalactosaminyltransferase-1.	Chondroitin Sulfates	211-230	chondroitin sulfate synthase 1	Homo sapiens	17-39
23811343-11	2013	GENERAL SIGNIFICANCE: The elongation of chondroitin sulfate chains may be tightly regulated by the cooperative expression of chondroitin synthase-1 and chondroitin N-acetylgalactosaminyltransferase-1 in peripheral neurons and peripheral neuropathies may result from synthesis of abnormally truncated chondroitin sulfate chains.	Chondroitin Sulfates	40-59	chondroitin sulfate synthase 1	Homo sapiens	125-147
23811343-11	2013	GENERAL SIGNIFICANCE: The elongation of chondroitin sulfate chains may be tightly regulated by the cooperative expression of chondroitin synthase-1 and chondroitin N-acetylgalactosaminyltransferase-1 in peripheral neurons and peripheral neuropathies may result from synthesis of abnormally truncated chondroitin sulfate chains.	Chondroitin Sulfates	300-319	chondroitin sulfate synthase 1	Homo sapiens	125-147
23940048-0	2013	Semaphorin 3A binds to the perineuronal nets via chondroitin sulfate type E motifs in rodent brains.	Chondroitin Sulfates	49-68	semaphorin 3A	Rattus norvegicus	0-13
23385884-1	2013	N-acetylgalactosamine-4-sulfatase (Arylsulfatase B; ARSB) is the enzyme that removes sulfate groups from the N-acetylgalactosamine-4-sulfate residue at the non-reducing end of chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	176-197	arylsulfatase B	Rattus norvegicus	0-33
23385884-1	2013	N-acetylgalactosamine-4-sulfatase (Arylsulfatase B; ARSB) is the enzyme that removes sulfate groups from the N-acetylgalactosamine-4-sulfate residue at the non-reducing end of chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	176-197	arylsulfatase B	Rattus norvegicus	35-50
23385884-1	2013	N-acetylgalactosamine-4-sulfatase (Arylsulfatase B; ARSB) is the enzyme that removes sulfate groups from the N-acetylgalactosamine-4-sulfate residue at the non-reducing end of chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	176-197	arylsulfatase B	Rattus norvegicus	52-56
23385884-1	2013	N-acetylgalactosamine-4-sulfatase (Arylsulfatase B; ARSB) is the enzyme that removes sulfate groups from the N-acetylgalactosamine-4-sulfate residue at the non-reducing end of chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	199-202	arylsulfatase B	Rattus norvegicus	0-33
23385884-1	2013	N-acetylgalactosamine-4-sulfatase (Arylsulfatase B; ARSB) is the enzyme that removes sulfate groups from the N-acetylgalactosamine-4-sulfate residue at the non-reducing end of chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	199-202	arylsulfatase B	Rattus norvegicus	35-50
23385884-1	2013	N-acetylgalactosamine-4-sulfatase (Arylsulfatase B; ARSB) is the enzyme that removes sulfate groups from the N-acetylgalactosamine-4-sulfate residue at the non-reducing end of chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	199-202	arylsulfatase B	Rattus norvegicus	52-56
23940048-9	2013	Here, we characterize the interaction of Sema3A with CS of the PNNs.	Chondroitin Sulfates	53-55	semaphorin 3A	Rattus norvegicus	41-47
23940048-10	2013	Recombinant Sema3A interacts with CS type E (CS-E), and this interaction is involved in the binding of Sema3A to rat brain-derived PNN glycosaminoglycans, as demonstrated by the use of CS-E blocking antibody GD3G7.	Chondroitin Sulfates	34-36	semaphorin 3A	Rattus norvegicus	12-18
23940048-10	2013	Recombinant Sema3A interacts with CS type E (CS-E), and this interaction is involved in the binding of Sema3A to rat brain-derived PNN glycosaminoglycans, as demonstrated by the use of CS-E blocking antibody GD3G7.	Chondroitin Sulfates	34-36	pinin, desmosome associated protein	Rattus norvegicus	131-134
23940048-14	2013	In conclusion, Sema3A binding to CS-E in the PNNs may be a mechanism whereby PNNs restrict growth and plasticity and may represent a possible point of intervention to facilitate neuronal plasticity.	Chondroitin Sulfates	33-35	semaphorin 3A	Rattus norvegicus	15-21
23968158-0	2013	Binding of chondroitin 4-sulfate to cathepsin S regulates its enzymatic activity.	Chondroitin Sulfates	11-32	cathepsin S	Felis catus	36-47
23531422-7	2013	CONCLUSIONS: Given that the conductivity requires doping of the polymer, these findings suggest that FN adhesion is mediated by interactions with chondroitin sulfate and hyaluronic acid at the polymer surface and may be indicative of specific interactions due to contributions from electrostatic attraction between the FN and sulfate/anionic groups of the dopants.	Chondroitin Sulfates	146-165	fibronectin 1	Homo sapiens	101-103
23360803-3	2013	To enable a novel approach in studies on DS versus CS roles during development and regeneration, we generated a mouse deficient in the dermatan 4-O-sulfotransferase1 (Chst14(-/-)), a key enzyme in the synthesis of iduronic acid-containing modules found in DS but not CS.	Chondroitin Sulfates	267-269	carbohydrate sulfotransferase 14	Mus musculus	167-173
23559035-2	2013	(hbd) PRELP inhibits osteoclastogenesis entering pre-fusion osteoclasts through a chondroitin sulfate- and annexin 2-dependent mechanism and reducing the nuclear factor-kappaB transcription factor activity.	Chondroitin Sulfates	82-101	exocyst complex component 6	Mus musculus	1-4
23559035-2	2013	(hbd) PRELP inhibits osteoclastogenesis entering pre-fusion osteoclasts through a chondroitin sulfate- and annexin 2-dependent mechanism and reducing the nuclear factor-kappaB transcription factor activity.	Chondroitin Sulfates	82-101	proline arginine-rich end leucine-rich repeat	Mus musculus	6-11
23726668-8	2013	Joint analysis of these 18 SNPs resulted in the strongest signal coming from rs7816924 (p=2.11x10(-7)), which resides in chondroitin sulfate N-acetylgalactosaminyltransferase 1 gene (CSGALNACT1).	Chondroitin Sulfates	121-140	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	183-193
23835622-1	2013	BACKGROUND: The enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) degrades chondroitin-4-sulfate (C4S) and is reduced in malignant colonic and mammary tissues but has not previously been evaluated in prostate cancer.	Chondroitin Sulfates	90-111	arylsulfatase B	Homo sapiens	23-38
23835622-1	2013	BACKGROUND: The enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) degrades chondroitin-4-sulfate (C4S) and is reduced in malignant colonic and mammary tissues but has not previously been evaluated in prostate cancer.	Chondroitin Sulfates	90-111	arylsulfatase B	Homo sapiens	40-44
23835622-1	2013	BACKGROUND: The enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) degrades chondroitin-4-sulfate (C4S) and is reduced in malignant colonic and mammary tissues but has not previously been evaluated in prostate cancer.	Chondroitin Sulfates	90-111	arylsulfatase B	Homo sapiens	46-79
23835622-1	2013	BACKGROUND: The enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) degrades chondroitin-4-sulfate (C4S) and is reduced in malignant colonic and mammary tissues but has not previously been evaluated in prostate cancer.	Chondroitin Sulfates	113-116	arylsulfatase B	Homo sapiens	23-38
23835622-1	2013	BACKGROUND: The enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) degrades chondroitin-4-sulfate (C4S) and is reduced in malignant colonic and mammary tissues but has not previously been evaluated in prostate cancer.	Chondroitin Sulfates	113-116	arylsulfatase B	Homo sapiens	40-44
23835622-1	2013	BACKGROUND: The enzyme arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) degrades chondroitin-4-sulfate (C4S) and is reduced in malignant colonic and mammary tissues but has not previously been evaluated in prostate cancer.	Chondroitin Sulfates	113-116	arylsulfatase B	Homo sapiens	46-79
23835622-11	2013	CONCLUSIONS: Study findings suggest that ARSB may be useful as a prognostic biomarker in prostate cancer and that the biological action of ARSB on chondroitin sulfate may impact upon versican"s effects in the tumor microenvironment.	Chondroitin Sulfates	147-166	arylsulfatase B	Homo sapiens	139-143
23964200-7	2013	In addition, real time PCR assays revealed an increase in the levels of the heparan sulfate proteoglycans, Glypican 1 (GPC-1) and Syndecans 3 e 4 (SDC-3 e SDC-4), followed by a decrease in the levels of the chondroitin sulfate proteoglycan, Versican.	Chondroitin Sulfates	207-226	glypican 1	Mus musculus	107-117
23801333-0	2013	Sulfation of the bikunin chondroitin sulfate chain determines heavy chain hyaluronan complex formation.	Chondroitin Sulfates	25-44	alpha-1-microglobulin/bikunin precursor	Homo sapiens	17-24
23801333-1	2013	Inter-alpha-trypsin inhibitor (IalphaI) is a complex comprising two heavy chains (HCs) that are covalently bound by an ester bond to chondroitin sulfate (CS), which itself is attached to Ser-10 of bikunin.	Chondroitin Sulfates	133-152	alpha-1-microglobulin/bikunin precursor	Homo sapiens	197-204
23801333-1	2013	Inter-alpha-trypsin inhibitor (IalphaI) is a complex comprising two heavy chains (HCs) that are covalently bound by an ester bond to chondroitin sulfate (CS), which itself is attached to Ser-10 of bikunin.	Chondroitin Sulfates	154-156	alpha-1-microglobulin/bikunin precursor	Homo sapiens	197-204
23801333-4	2013	Bikunin has been isolated previously by anion exchange chromatography with a salt gradient up to 0.5 M NaCl and found to contain unsulfated and 4-sulfated CS disaccharides.	Chondroitin Sulfates	155-157	alpha-1-microglobulin/bikunin precursor	Homo sapiens	0-7
23801333-5	2013	In this study, bikunin-containing fractions in plasma and urine were separated by anion exchange chromatography with a salt gradient of 0.1-1.0 M NaCl, and fractions were analyzed for their reactivity with the 4-sulfated CS linkage region antibody (2B6).	Chondroitin Sulfates	221-223	alpha-1-microglobulin/bikunin precursor	Homo sapiens	15-22
23801333-8	2013	Furthermore, these data highlight that the structure of the CS attached to bikunin is important for the transfer of HC onto HA and emphasize a specific role of CS chain sulfation.	Chondroitin Sulfates	60-62	alpha-1-microglobulin/bikunin precursor	Homo sapiens	75-82
23801333-8	2013	Furthermore, these data highlight that the structure of the CS attached to bikunin is important for the transfer of HC onto HA and emphasize a specific role of CS chain sulfation.	Chondroitin Sulfates	160-162	alpha-1-microglobulin/bikunin precursor	Homo sapiens	75-82
23597636-4	2013	In the present study, we characterized the developmental time course of the formation of PNNs in the mouse primary visual cortex, using the specific antibodies against the two PNN component proteins aggrecan and tenascin-R, or the lectin Wisteria floribunda agglutinin (WFA) that directly binds to glycosaminoglycan chains of chondroitin sulfate proteoglycans (CSPGs).	Chondroitin Sulfates	326-345	pinin	Mus musculus	89-92
23696150-5	2013	It was found that both CHST3 and CHST15 have higher activities at the non-reducing end (NRE) units of chondroitin sulfate, particularly those terminating with a GalNAc monosaccharide.	Chondroitin Sulfates	102-121	carbohydrate sulfotransferase 3	Homo sapiens	23-28
23696150-5	2013	It was found that both CHST3 and CHST15 have higher activities at the non-reducing end (NRE) units of chondroitin sulfate, particularly those terminating with a GalNAc monosaccharide.	Chondroitin Sulfates	102-121	carbohydrate sulfotransferase 15	Homo sapiens	33-39
23517225-1	2013	The beneficial effect of interventions with chondroitinase ABC enzyme to reduce axon growth-inhibitory chondroitin sulphate side chains after central nervous system injuries has been mainly attributed to enhanced axonal sprouting.	Chondroitin Sulfates	103-123	galactosamine (N-acetyl)-6-sulfatase	Rattus norvegicus	44-58
23744080-4	2013	By IL-34 affinity chromatography of solubilized mouse brain membrane followed by mass spectrometric analysis, we identified receptor-type protein-tyrosine phosphatase zeta (PTP-zeta), a cell surface chondroitin sulfate (CS) proteoglycan, as a novel IL-34 receptor.	Chondroitin Sulfates	199-218	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	173-181
23744080-4	2013	By IL-34 affinity chromatography of solubilized mouse brain membrane followed by mass spectrometric analysis, we identified receptor-type protein-tyrosine phosphatase zeta (PTP-zeta), a cell surface chondroitin sulfate (CS) proteoglycan, as a novel IL-34 receptor.	Chondroitin Sulfates	220-222	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	173-181
23744080-8	2013	IL-34 binding to U251 cells was abrogated by chondroitinase ABC treatment, and CS competed with IL-34 for binding to the extracellular domain of PTP-zeta and to the cells, indicating a dependence of binding on PTP-zeta CS moieties.	Chondroitin Sulfates	79-81	protein tyrosine phosphatase receptor type Z1	Homo sapiens	145-153
23744080-8	2013	IL-34 binding to U251 cells was abrogated by chondroitinase ABC treatment, and CS competed with IL-34 for binding to the extracellular domain of PTP-zeta and to the cells, indicating a dependence of binding on PTP-zeta CS moieties.	Chondroitin Sulfates	79-81	protein tyrosine phosphatase receptor type Z1	Homo sapiens	210-218
23744080-8	2013	IL-34 binding to U251 cells was abrogated by chondroitinase ABC treatment, and CS competed with IL-34 for binding to the extracellular domain of PTP-zeta and to the cells, indicating a dependence of binding on PTP-zeta CS moieties.	Chondroitin Sulfates	219-221	interleukin 34	Homo sapiens	0-5
23744080-8	2013	IL-34 binding to U251 cells was abrogated by chondroitinase ABC treatment, and CS competed with IL-34 for binding to the extracellular domain of PTP-zeta and to the cells, indicating a dependence of binding on PTP-zeta CS moieties.	Chondroitin Sulfates	219-221	protein tyrosine phosphatase receptor type Z1	Homo sapiens	145-153
23744080-8	2013	IL-34 binding to U251 cells was abrogated by chondroitinase ABC treatment, and CS competed with IL-34 for binding to the extracellular domain of PTP-zeta and to the cells, indicating a dependence of binding on PTP-zeta CS moieties.	Chondroitin Sulfates	219-221	protein tyrosine phosphatase receptor type Z1	Homo sapiens	210-218
23517225-6	2013	After injury, chondroitin sulfate proteoglycan digestion produced the expected increase in growth-associated protein 43-positive axons and perikarya, of which a significantly greater number were double labeled for c-Fos after intervention with chondroitinase, compared to vehicle.	Chondroitin Sulfates	14-33	growth associated protein 43	Rattus norvegicus	91-119
23517225-6	2013	After injury, chondroitin sulfate proteoglycan digestion produced the expected increase in growth-associated protein 43-positive axons and perikarya, of which a significantly greater number were double labeled for c-Fos after intervention with chondroitinase, compared to vehicle.	Chondroitin Sulfates	14-33	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	214-219
23517225-6	2013	After injury, chondroitin sulfate proteoglycan digestion produced the expected increase in growth-associated protein 43-positive axons and perikarya, of which a significantly greater number were double labeled for c-Fos after intervention with chondroitinase, compared to vehicle.	Chondroitin Sulfates	14-33	galactosamine (N-acetyl)-6-sulfatase	Rattus norvegicus	244-258
23845159-8	2013	CCL2 bound to CS chains of versican and colocalized with versican in the monocytes" Golgi apparatus.	Chondroitin Sulfates	14-16	C-C motif chemokine ligand 2	Homo sapiens	0-4
23547049-5	2013	Engagement of CD44 by its natural ligands, hyaluronic acid or chondroitin sulfate, protected CLL cells from apoptosis, while anti-CD44 small interfering RNAs impaired tumor cell viability.	Chondroitin Sulfates	62-81	CD44 antigen	Mus musculus	14-18
23603511-6	2013	Fine mapping revealed that the cysteine-rich domain of MRC binds to the chondroitin sulfate side chains of CD44.	Chondroitin Sulfates	72-91	CD44 antigen	Mus musculus	107-111
23590340-7	2013	Also, L-CS exhibited a higher anti-inflammatory activity than CS in stimulated cells by reducing the level of IL-8 and TNF-alpha proinflammatory cytokines.	Chondroitin Sulfates	8-10	chemokine (C-X-C motif) ligand 15	Mus musculus	110-114
23590340-7	2013	Also, L-CS exhibited a higher anti-inflammatory activity than CS in stimulated cells by reducing the level of IL-8 and TNF-alpha proinflammatory cytokines.	Chondroitin Sulfates	8-10	tumor necrosis factor	Mus musculus	119-128
23249362-6	2013	Compared to OPCs derived from hESCs grown on ECM of animal origin, higher levels of NG2, a chondroitin sulfate proteoglycan expressed by OPCs, were observed in OPCs differentiated from H1 hESCs grown on VN-PAS, while the expression levels of Nestin and PDGFRalpha were comparable.	Chondroitin Sulfates	91-110	chondroitin sulfate proteoglycan 4	Homo sapiens	84-87
23360476-5	2013	Recently, receptor for advanced glycation end-products (RAGE), which is predominantly expressed in the lung, was identified as a functional receptor for CS chains containing E units.	Chondroitin Sulfates	153-155	advanced glycosylation end product-specific receptor	Mus musculus	10-54
23376131-2	2013	The phenomenon involves a parasite-derived variant antigen, the P. falciparum erythrocyte membrane protein 1 (PfEMP1), and several human host receptors, such as chondroitin sulfate A (CSA), which has been explicitly implicated in placental malaria.	Chondroitin Sulfates	161-182	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	184-187
23845159-9	2013	Finally, CCL2 had a greater ability to mediate monocyte migration when bound to CS chains, because this binding provided efficient formation of CCL2 gradients and protection from protease attack.	Chondroitin Sulfates	80-82	C-C motif chemokine ligand 2	Homo sapiens	9-13
23845159-9	2013	Finally, CCL2 had a greater ability to mediate monocyte migration when bound to CS chains, because this binding provided efficient formation of CCL2 gradients and protection from protease attack.	Chondroitin Sulfates	80-82	C-C motif chemokine ligand 2	Homo sapiens	144-148
23207329-6	2013	SLN were based on chondroitin sulfate and sodium hyaluronate, bioactive polymers characterized by well-known tissue repairing properties.	Chondroitin Sulfates	18-37	sarcolipin	Homo sapiens	0-3
23360476-5	2013	Recently, receptor for advanced glycation end-products (RAGE), which is predominantly expressed in the lung, was identified as a functional receptor for CS chains containing E units.	Chondroitin Sulfates	153-155	advanced glycosylation end product-specific receptor	Mus musculus	56-60
23462864-0	2013	Reversible binding and quantification of heparin and chondroitin sulfate in water using redox-stable biferrocenylene SAMs.	Chondroitin Sulfates	53-72	methionine adenosyltransferase 1A	Homo sapiens	117-121
23451938-5	2013	Using a model system, we show herein that treatment of keloid tissues with chondroitinase ABC, an enzyme that specifically digests CS, improves clinical features of keloids.	Chondroitin Sulfates	131-133	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	75-89
23504321-0	2013	Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity.	Chondroitin Sulfates	124-143	syndecan 1	Homo sapiens	33-43
23462864-2	2013	The resulting SAMs with their extraordinary stability in the monocationic state were used to detect and quantify heparin (3-300 x 10(-5) g L(-1) = 0.003-0.3 U mL(-1)) and chondroitin sulfate (3-250 x 10(-5) g L(-1)) in aqueous buffer by cyclic voltammetry, square wave voltammetry and surface plasmon resonance.	Chondroitin Sulfates	171-190	methionine adenosyltransferase 1A	Homo sapiens	14-18
23319559-1	2013	Placental malaria (PM) is characterized by infected erythrocytes (IEs) that selectively bind to chondroitin sulfate A (CSA) and sequester in placental tissue.	Chondroitin Sulfates	96-117	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	119-122
23401410-1	2013	Mucopolysaccharidosis IVA (MPS IVA; OMIM #253000) is caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), a lysosomal enzyme involved in the catabolism of keratan and chondroitin sulfate.	Chondroitin Sulfates	193-212	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	124-129
23276728-0	2013	Potential antipsoriatic effect of chondroitin sulfate through inhibition of NF-kappaB and STAT3 in human keratinocytes.	Chondroitin Sulfates	34-53	signal transducer and activator of transcription 3	Homo sapiens	90-95
23276728-5	2013	In the present study we report the pharmacological modulation of the NF-kappaB and STAT3 signaling pathways by CS in normal human keratinocytes.	Chondroitin Sulfates	111-113	signal transducer and activator of transcription 3	Homo sapiens	83-88
23276728-6	2013	CS inhibited NF-kappaB activation and the release of some of the key psoriatic cytokines such as TNFalpha, IL-8, IL-6 and CCL27.	Chondroitin Sulfates	0-2	tumor necrosis factor	Homo sapiens	97-105
23276728-6	2013	CS inhibited NF-kappaB activation and the release of some of the key psoriatic cytokines such as TNFalpha, IL-8, IL-6 and CCL27.	Chondroitin Sulfates	0-2	C-X-C motif chemokine ligand 8	Homo sapiens	107-111
23276728-6	2013	CS inhibited NF-kappaB activation and the release of some of the key psoriatic cytokines such as TNFalpha, IL-8, IL-6 and CCL27.	Chondroitin Sulfates	0-2	interleukin 6	Homo sapiens	113-117
23276728-6	2013	CS inhibited NF-kappaB activation and the release of some of the key psoriatic cytokines such as TNFalpha, IL-8, IL-6 and CCL27.	Chondroitin Sulfates	0-2	C-C motif chemokine ligand 27	Homo sapiens	122-127
23033806-5	2013	Among the four types of CS (A, C, D, and E), the E type (CSE), which was derived from the squid cartilage, exhibited anti-HTLV-1 activity.	Chondroitin Sulfates	24-26	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	57-60
22718137-0	2013	Over-sulfated chondroitin sulfate derivatives induce osteogenic differentiation of hMSC independent of BMP-2 and TGF-beta1 signalling.	Chondroitin Sulfates	14-33	musculin	Homo sapiens	83-87
23345587-2	2013	VAR2CSA, which is comprised of a series of six Duffy binding-like (DBL) domains, binds chondroitin sulfate A (CSA) on placental syncytiotrophoblast.	Chondroitin Sulfates	87-108	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	4-7
22550062-1	2013	The enzyme Arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) removes 4-sulfate groups from chondroitin-4-sulfate and dermatan sulfate and is required for the degradation of these sulfated glycosaminoglycans (sGAGs).	Chondroitin Sulfates	99-120	arylsulfatase B	Homo sapiens	11-26
22550062-1	2013	The enzyme Arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) removes 4-sulfate groups from chondroitin-4-sulfate and dermatan sulfate and is required for the degradation of these sulfated glycosaminoglycans (sGAGs).	Chondroitin Sulfates	99-120	arylsulfatase B	Homo sapiens	28-32
22550062-1	2013	The enzyme Arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) removes 4-sulfate groups from chondroitin-4-sulfate and dermatan sulfate and is required for the degradation of these sulfated glycosaminoglycans (sGAGs).	Chondroitin Sulfates	99-120	arylsulfatase B	Homo sapiens	34-67
23019154-2	2013	CS chains containing D-disaccharide units [GlcUA(2-O-sulfate)-GalNAc(6-O-sulfate)] are involved in the development of cerebellar Purkinje cells and neurite outgrowth-promoting activity through interaction with a neurotrophic factor, pleiotrophin, resulting in the regulation of signaling.	Chondroitin Sulfates	0-2	pleiotrophin	Homo sapiens	233-245
22718137-5	2013	The BMP-2-induced Smad1/5 activation was inhibited in the presence of over-sulfated CS derivatives leading to a loss of BMP-2-induced TNAP activity and calcium deposition.	Chondroitin Sulfates	84-86	bone morphogenetic protein 2	Homo sapiens	4-9
22718137-5	2013	The BMP-2-induced Smad1/5 activation was inhibited in the presence of over-sulfated CS derivatives leading to a loss of BMP-2-induced TNAP activity and calcium deposition.	Chondroitin Sulfates	84-86	SMAD family member 1	Homo sapiens	18-25
22718137-5	2013	The BMP-2-induced Smad1/5 activation was inhibited in the presence of over-sulfated CS derivatives leading to a loss of BMP-2-induced TNAP activity and calcium deposition.	Chondroitin Sulfates	84-86	bone morphogenetic protein 2	Homo sapiens	120-125
22718137-8	2013	These data suggest that over-sulfated CS derivatives themselves are able to induce osteogenic differentiation, probably independent of BMP-2 and TGF-beta1 signalling, and offer therefore an interesting approach for the improvement of bone healing.	Chondroitin Sulfates	38-40	bone morphogenetic protein 2	Homo sapiens	135-140
22718137-8	2013	These data suggest that over-sulfated CS derivatives themselves are able to induce osteogenic differentiation, probably independent of BMP-2 and TGF-beta1 signalling, and offer therefore an interesting approach for the improvement of bone healing.	Chondroitin Sulfates	38-40	transforming growth factor beta 1	Homo sapiens	145-154
23337203-4	2013	With the optimum NHS/EDC molar ratio of 0.5, chemical treatment could achieve relatively high CS content in the gelatin scaffolds, thereby enhancing the water content, glucose permeation, and fibronectin adsorption.	Chondroitin Sulfates	94-96	fibronectin 1	Homo sapiens	192-203
23348932-4	2013	Thanks, in fact, to its considerable functional versatility, MLT can exert both direct and indirect anticancer effects in factorial synergy with other differentiating, antiproliferative, immunomodulating and trophic molecules that form part of the anticancer treatment formulated by Luigi Di Bella (Di Bella Method, DBM: somatostatin, retinoids, ascorbic acid, vitamin D3, prolactin inhibitors, chondroitin-sulfate).	Chondroitin Sulfates	395-414	MALT1 paracaspase	Homo sapiens	61-64
24200792-3	2013	In liver tissue, CHS/RSG significantly normalized the activities of hexokinase, pyruvate kinase, and glucose-6-phosphatase.	Chondroitin Sulfates	17-20	glucose-6-phosphatase, catalytic	Mus musculus	101-122
24390942-2	2013	Versican is a chondroitin sulfate proteoglycan and is a key ingredient of the extracellular matrix.	Chondroitin Sulfates	14-33	versican	Homo sapiens	0-8
23215683-2	2013	METHODS: A nanocomplex system between the positively charged TRAIL and the negatively charged chondroitin sulfate (CS) (CS/TRAIL) was designed and applied in poly(lactide-co-glycolide) (PLGA) microspheres (MSs).	Chondroitin Sulfates	94-113	TNF superfamily member 10	Homo sapiens	123-128
23237500-0	2013	Incomplete elongation of the chondroitin sulfate linkage region on aggrecan and response to interleukin-1beta.	Chondroitin Sulfates	29-48	interleukin 1 beta	Homo sapiens	92-109
23215683-2	2013	METHODS: A nanocomplex system between the positively charged TRAIL and the negatively charged chondroitin sulfate (CS) (CS/TRAIL) was designed and applied in poly(lactide-co-glycolide) (PLGA) microspheres (MSs).	Chondroitin Sulfates	115-117	TNF superfamily member 10	Homo sapiens	123-128
23215683-3	2013	KEY FINDINGS: A nanocomplex of approximately 200 nm was easily formed in a weight ratio of 2 TRAIL to CS (TC2) at pH 5.0.	Chondroitin Sulfates	102-104	TNF superfamily member 10	Homo sapiens	93-98
23215683-3	2013	KEY FINDINGS: A nanocomplex of approximately 200 nm was easily formed in a weight ratio of 2 TRAIL to CS (TC2) at pH 5.0.	Chondroitin Sulfates	102-104	transcobalamin 2	Homo sapiens	106-109
23129769-4	2012	Reactions with chondroitin polymerase generated non-sulfated chondroitin, and those with C4ST-1 and C6ST-1 generated uniformly sulfated CS containing &gt;95% 4S and 6S units, respectively.	Chondroitin Sulfates	136-138	carbohydrate sulfotransferase 11	Homo sapiens	89-95
23349846-1	2013	N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) is the sulfotransferase responsible for biosynthesis of highly sulfated chondroitin sulfate CS-E.	Chondroitin Sulfates	140-159	carbohydrate sulfotransferase 15	Homo sapiens	54-66
23349846-1	2013	N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) is the sulfotransferase responsible for biosynthesis of highly sulfated chondroitin sulfate CS-E.	Chondroitin Sulfates	140-159	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	160-164
23129769-7	2012	Surprisingly, sequential reactions with GalNAc4S-6ST and UA2ST generated a novel CS molecule containing ~29% trisulfated disaccharide units.	Chondroitin Sulfates	81-83	carbohydrate sulfotransferase 15	Homo sapiens	40-52
23129769-4	2012	Reactions with chondroitin polymerase generated non-sulfated chondroitin, and those with C4ST-1 and C6ST-1 generated uniformly sulfated CS containing &gt;95% 4S and 6S units, respectively.	Chondroitin Sulfates	136-138	carbohydrate sulfotransferase 3	Homo sapiens	100-106
23129769-5	2012	GalNAc4S-6ST and UA2ST generated highly sulfated CS possessing ~90% corresponding disulfated disaccharide units.	Chondroitin Sulfates	49-51	carbohydrate sulfotransferase 15	Homo sapiens	0-12
23129769-6	2012	Sequential reactions with UA2ST and GalNAc4S-6ST generated further highly sulfated CS containing a mixed structure of disulfated units.	Chondroitin Sulfates	83-85	carbohydrate sulfotransferase 15	Homo sapiens	36-48
23045626-3	2012	The principal ligand associated with the binding to chondroitin sulfate A (CSA) that allows placental sequestration of IEs is a P. falciparum erythrocyte membrane protein 1 (PfEMP1) family member encoded by the var2csa gene.	Chondroitin Sulfates	52-73	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	75-78
23086929-1	2012	Human hyaluronidase-4 (hHYAL4), a member of the hyaluronidase family, has no hyaluronidase activity, but is a chondroitin sulfate (CS)-specific endo-beta-N-acetylgalactosaminidase.	Chondroitin Sulfates	110-129	hyaluronidase 4	Homo sapiens	6-21
23086929-1	2012	Human hyaluronidase-4 (hHYAL4), a member of the hyaluronidase family, has no hyaluronidase activity, but is a chondroitin sulfate (CS)-specific endo-beta-N-acetylgalactosaminidase.	Chondroitin Sulfates	110-129	hyaluronidase 4	Homo sapiens	23-29
23086929-1	2012	Human hyaluronidase-4 (hHYAL4), a member of the hyaluronidase family, has no hyaluronidase activity, but is a chondroitin sulfate (CS)-specific endo-beta-N-acetylgalactosaminidase.	Chondroitin Sulfates	131-133	hyaluronidase 4	Homo sapiens	6-21
23086929-1	2012	Human hyaluronidase-4 (hHYAL4), a member of the hyaluronidase family, has no hyaluronidase activity, but is a chondroitin sulfate (CS)-specific endo-beta-N-acetylgalactosaminidase.	Chondroitin Sulfates	131-133	hyaluronidase 4	Homo sapiens	23-29
23086929-2	2012	The expression of hHYAL4 is not ubiquitous but restricted to placenta, skeletal muscle, and testis, suggesting that hHYAL4 is not involved in the systemic catabolism of CS, but rather has specific functions in particular organs or tissues.	Chondroitin Sulfates	169-171	hyaluronidase 4	Homo sapiens	116-122
23086929-4	2012	mHyal4 was also demonstrated to be a CS-specific endo-beta-N-acetylgalactosaminidase.	Chondroitin Sulfates	37-39	hyaluronoglucosaminidase 4	Mus musculus	0-6
23086929-6	2012	Although hHYAL4 strongly preferred GlcUA(2-O-sulfate)-GalNAc(6-O-sulfate)-containing sequences typical in CS-D, where GlcUA represents d-glucuronic acid, mHyal4 depolymerized various CS isoforms to a similar extent, suggesting broad substrate specificity.	Chondroitin Sulfates	106-108	hyaluronidase 4	Homo sapiens	9-15
23190696-8	2012	Chondroprotective drugs such as chondroitin sulfate (CS) and the traditional Korean medicine, BaekJeol-Tang (BT) decrease production of TSLP and activation of caspase-1 and nuclear factor-kappaB.	Chondroitin Sulfates	32-51	thymic stromal lymphopoietin	Homo sapiens	136-140
23555092-0	2013	Expression of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase involved in chondroitin sulfate synthesis is responsible for pulmonary metastasis.	Chondroitin Sulfates	79-98	carbohydrate sulfotransferase 15	Mus musculus	14-66
23099107-2	2012	Versican, a large chondroitin sulfate proteoglycan and one of the major components of the extracellular matrix, plays an essential role in hair follicle formation.	Chondroitin Sulfates	18-37	versican	Homo sapiens	0-8
22674584-5	2012	Here we investigate the expression of PRG4 mRNA and protein by primary bovine superficial zone chondrocytes, middle/deep zone chondrocytes, and mesenchymal stem cells encapsulated in alginate hydrogels with hyaluronic acid (HA) and chondroitin sulfate (CS) additives.	Chondroitin Sulfates	232-251	proteoglycan 4	Bos taurus	38-42
22674584-5	2012	Here we investigate the expression of PRG4 mRNA and protein by primary bovine superficial zone chondrocytes, middle/deep zone chondrocytes, and mesenchymal stem cells encapsulated in alginate hydrogels with hyaluronic acid (HA) and chondroitin sulfate (CS) additives.	Chondroitin Sulfates	253-255	proteoglycan 4	Bos taurus	38-42
22674584-10	2012	Conversely, PRG4 mRNA expression is downregulated (up to 5-fold) by CS and HA in differentiating MSCs, possibly due to build up of entrapped protein.	Chondroitin Sulfates	68-70	proteoglycan 4	Bos taurus	12-16
22674584-11	2012	HA and CS demonstrate favorable effects on chondrogenesis by upregulating transcription factor Sox9 mRNA (up to 4.6-fold) and downregulating type I collagen mRNA (up to 18-fold).	Chondroitin Sulfates	7-9	SRY-box transcription factor 9	Bos taurus	95-99
22985769-0	2012	A highly-sulfated chondroitin sulfate, CS-E, adsorbs specifically to neurons with nuclear condensation.	Chondroitin Sulfates	18-37	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	39-43
22985769-1	2012	A highly sulfated chondroitin sulfate, CS-E, prevents excitatory amino acid-induced neuronal cell death by an as yet unknown mechanism.	Chondroitin Sulfates	18-37	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	39-43
23190696-8	2012	Chondroprotective drugs such as chondroitin sulfate (CS) and the traditional Korean medicine, BaekJeol-Tang (BT) decrease production of TSLP and activation of caspase-1 and nuclear factor-kappaB.	Chondroitin Sulfates	32-51	caspase 1	Homo sapiens	159-168
23190696-8	2012	Chondroprotective drugs such as chondroitin sulfate (CS) and the traditional Korean medicine, BaekJeol-Tang (BT) decrease production of TSLP and activation of caspase-1 and nuclear factor-kappaB.	Chondroitin Sulfates	53-55	thymic stromal lymphopoietin	Homo sapiens	136-140
23190696-8	2012	Chondroprotective drugs such as chondroitin sulfate (CS) and the traditional Korean medicine, BaekJeol-Tang (BT) decrease production of TSLP and activation of caspase-1 and nuclear factor-kappaB.	Chondroitin Sulfates	53-55	caspase 1	Homo sapiens	159-168
23190696-9	2012	In addition, CS and BT inhibited IL-32-induced monocytes differentiation.	Chondroitin Sulfates	13-15	interleukin 32	Homo sapiens	33-38
23190696-11	2012	The effects of CS and BT were associated with the downregulation of TSLP and caspase-1 through negative regulation of IL-32 pathways in RA.	Chondroitin Sulfates	15-17	thymic stromal lymphopoietin	Homo sapiens	68-72
23190696-11	2012	The effects of CS and BT were associated with the downregulation of TSLP and caspase-1 through negative regulation of IL-32 pathways in RA.	Chondroitin Sulfates	15-17	caspase 1	Homo sapiens	77-86
23190696-11	2012	The effects of CS and BT were associated with the downregulation of TSLP and caspase-1 through negative regulation of IL-32 pathways in RA.	Chondroitin Sulfates	15-17	interleukin 32	Homo sapiens	118-123
24970149-4	2012	Although human hyaluronidase-1 (HYAL1) and testicular hyaluronidase (SPAM1) can degrade not only HA but also CS, they are assumed to digest CS to only a limited extent.	Chondroitin Sulfates	109-111	hyaluronidase 1	Homo sapiens	15-30
22940367-6	2012	The active site of GALNS is a large, positively charged trench suitable for binding polyanionic substrates such as keratan sulfate and chondroitin-6-sulfate.	Chondroitin Sulfates	135-156	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	19-24
23007393-4	2012	This characteristic CS reduction seems to occur through a cell-autonomous mechanism that involves HYAL1, a known catabolic enzyme for hyaluronan and CS.	Chondroitin Sulfates	20-22	hyaluronoglucosaminidase 1	Mus musculus	98-103
23007393-4	2012	This characteristic CS reduction seems to occur through a cell-autonomous mechanism that involves HYAL1, a known catabolic enzyme for hyaluronan and CS.	Chondroitin Sulfates	149-151	hyaluronoglucosaminidase 1	Mus musculus	98-103
24970149-4	2012	Although human hyaluronidase-1 (HYAL1) and testicular hyaluronidase (SPAM1) can degrade not only HA but also CS, they are assumed to digest CS to only a limited extent.	Chondroitin Sulfates	109-111	hyaluronidase 1	Homo sapiens	32-37
24970149-4	2012	Although human hyaluronidase-1 (HYAL1) and testicular hyaluronidase (SPAM1) can degrade not only HA but also CS, they are assumed to digest CS to only a limited extent.	Chondroitin Sulfates	109-111	sperm adhesion molecule 1	Homo sapiens	69-74
24970149-4	2012	Although human hyaluronidase-1 (HYAL1) and testicular hyaluronidase (SPAM1) can degrade not only HA but also CS, they are assumed to digest CS to only a limited extent.	Chondroitin Sulfates	140-142	hyaluronidase 1	Homo sapiens	15-30
24970149-4	2012	Although human hyaluronidase-1 (HYAL1) and testicular hyaluronidase (SPAM1) can degrade not only HA but also CS, they are assumed to digest CS to only a limited extent.	Chondroitin Sulfates	140-142	hyaluronidase 1	Homo sapiens	32-37
24970149-4	2012	Although human hyaluronidase-1 (HYAL1) and testicular hyaluronidase (SPAM1) can degrade not only HA but also CS, they are assumed to digest CS to only a limited extent.	Chondroitin Sulfates	140-142	sperm adhesion molecule 1	Homo sapiens	69-74
22915582-0	2012	Inhibition by chondroitin sulfate E can specify functional Wnt/beta-catenin signaling thresholds in NIH3T3 fibroblasts.	Chondroitin Sulfates	14-33	catenin beta 1	Homo sapiens	63-75
22887999-0	2012	Role of UDP-N-acetylglucosamine (GlcNAc) and O-GlcNAcylation of hyaluronan synthase 2 in the control of chondroitin sulfate and hyaluronan synthesis.	Chondroitin Sulfates	104-123	hyaluronan synthase 2	Homo sapiens	64-85
23097628-5	2012	We provide evidence that one third of BM-derived GFP(+) cells infiltrating the tumor expressed the chondroitin sulfate proteoglycan NG2 (pericytic marker) or alpha-smooth muscle actin (alpha-SMA, myofibroblast marker), whereas almost 90% of Thy1(+) fibroblasts were originating from resident GFP-negative cells.	Chondroitin Sulfates	99-118	chondroitin sulfate proteoglycan 4	Mus musculus	132-135
22915586-8	2012	Because NE is known to bind to heparan sulfate- and chondroitin sulfate-containing proteoglycans, we treated cells with glycanases to remove these confounding factors, which did not significantly diminish cell surface binding or endosomal entry.	Chondroitin Sulfates	52-71	elastase, neutrophil expressed	Homo sapiens	8-10
23031212-2	2012	The aim of this work is to find proteins whose secretion from cartilage cells under proinflammatory stimuli (IL-1beta) is regulated by CS, employing a novel quantitative proteomic approach.	Chondroitin Sulfates	135-137	interleukin 1 beta	Homo sapiens	109-117
23031212-9	2012	In normal chondrocytes stimulated with IL-1beta, CS reduces inflammation directly by decreasing the presence of several complement components (CFAB, C1S, CO3, and C1R) and also indirectly by increasing proteins such as TNFalpha-induced protein (TSG6).	Chondroitin Sulfates	49-51	interleukin 1 beta	Homo sapiens	39-47
23031212-9	2012	In normal chondrocytes stimulated with IL-1beta, CS reduces inflammation directly by decreasing the presence of several complement components (CFAB, C1S, CO3, and C1R) and also indirectly by increasing proteins such as TNFalpha-induced protein (TSG6).	Chondroitin Sulfates	49-51	complement C1s	Homo sapiens	149-152
23031212-9	2012	In normal chondrocytes stimulated with IL-1beta, CS reduces inflammation directly by decreasing the presence of several complement components (CFAB, C1S, CO3, and C1R) and also indirectly by increasing proteins such as TNFalpha-induced protein (TSG6).	Chondroitin Sulfates	49-51	complement C1r	Homo sapiens	163-166
23031212-9	2012	In normal chondrocytes stimulated with IL-1beta, CS reduces inflammation directly by decreasing the presence of several complement components (CFAB, C1S, CO3, and C1R) and also indirectly by increasing proteins such as TNFalpha-induced protein (TSG6).	Chondroitin Sulfates	49-51	TNF alpha induced protein 6	Homo sapiens	245-249
23031212-11	2012	Finally, we observed a strong CS-dependent increase of an angiogenesis inhibitor, thrombospondin-1.	Chondroitin Sulfates	30-32	thrombospondin 1	Homo sapiens	82-98
22772798-8	2012	Double immunofluorescence staining for alphaA-crystallin and NG2 chondroitin sulphate proteoglycan revealed that alphaA-crystallin was predominantly produced in the retinal pericyte and that the number of alphaA-crystallin-producing pericytes decreased in the diabetic retina.	Chondroitin Sulfates	65-85	chondroitin sulfate proteoglycan 4	Mus musculus	61-64
22869369-7	2012	Thus, the balance of the Extl3 and Csgalnact1/Csgalnact2 proteins influences the HS/CS ratio.	Chondroitin Sulfates	84-86	exostosin-like glycosyltransferase 3	Danio rerio	25-30
22869369-4	2012	In uxs1 and b3gat3 mutant larvae, biosynthesis of CS was shown to be virtually abolished, whereas these mutants still were capable of synthesizing 50% of the HS produced in control larvae.	Chondroitin Sulfates	50-52	UDP-glucuronate decarboxylase 1	Danio rerio	3-7
22869369-7	2012	Thus, the balance of the Extl3 and Csgalnact1/Csgalnact2 proteins influences the HS/CS ratio.	Chondroitin Sulfates	84-86	chondroitin sulfate N-acetylgalactosaminyltransferase 1a	Danio rerio	35-45
22869369-4	2012	In uxs1 and b3gat3 mutant larvae, biosynthesis of CS was shown to be virtually abolished, whereas these mutants still were capable of synthesizing 50% of the HS produced in control larvae.	Chondroitin Sulfates	50-52	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)	Danio rerio	12-18
22869369-6	2012	Further, extl3 mutants produced higher levels of CS than control larvae, whereas morpholino-mediated suppression of csgalnact1/csgalnact2 resulted in increased HS biosynthesis.	Chondroitin Sulfates	49-51	exostosin-like glycosyltransferase 3	Danio rerio	9-14
22869369-7	2012	Thus, the balance of the Extl3 and Csgalnact1/Csgalnact2 proteins influences the HS/CS ratio.	Chondroitin Sulfates	84-86	chondroitin sulfate N-acetylgalactosaminyltransferase 2	Danio rerio	46-56
22691363-13	2012	It was possible to note a significant increase of this particular chondroitin sulfate in the Tnc-deficient ECM.	Chondroitin Sulfates	66-85	tenascin C	Mus musculus	93-96
22909447-1	2012	Here we demonstrate a polysaccharide hydrogel reinforced with finely dispersed single-walled carbon nanotubes (SWNTs) using biocompatible dispersants O-carboxymethylchitosan (OC) and chondroitin sulfate A (CS-A) as a structural support.	Chondroitin Sulfates	183-204	chorionic somatomammotropin hormone 1	Homo sapiens	206-210
22985423-7	2012	Instead, C1q was concentrated in other brain regions, where it partially co-localized with a potential C1q inhibitor, chondroitin sulfate proteoglycan (CSPG).	Chondroitin Sulfates	118-137	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	9-12
22985423-7	2012	Instead, C1q was concentrated in other brain regions, where it partially co-localized with a potential C1q inhibitor, chondroitin sulfate proteoglycan (CSPG).	Chondroitin Sulfates	118-137	complement component 1, q subcomponent, alpha polypeptide	Mus musculus	103-106
22079206-7	2012	The ROS production from kappa-CGN was reduced by exposure to rhARSB, but increased by competition from C4S or DS, but not from chondroitin-6-sulfate.	Chondroitin Sulfates	103-106	cingulin	Homo sapiens	30-33
22265686-6	2012	It was demonstrated that PGIs become good substrates for GAG biosynthesis within the cells and high molecular weight GAGs primed by PGIs is chondroitin sulfate involving N-acetyl-d-galactosamine residues substituted by 4-O-sulfate or 6-O-sulfate group as major components.	Chondroitin Sulfates	140-159	prostaglandin I2 synthase	Homo sapiens	25-29
22265686-6	2012	It was demonstrated that PGIs become good substrates for GAG biosynthesis within the cells and high molecular weight GAGs primed by PGIs is chondroitin sulfate involving N-acetyl-d-galactosamine residues substituted by 4-O-sulfate or 6-O-sulfate group as major components.	Chondroitin Sulfates	140-159	prostaglandin I2 synthase	Homo sapiens	132-136
22692047-1	2012	Versican (Vcan)/proteoglycan (PG)-M is a large chondroitin sulfate proteoglycan which forms a proteoglycan/hyaluronan (HA) aggregate in the extracellular matrix (ECM).	Chondroitin Sulfates	47-66	versican	Mus musculus	10-14
22079206-0	2012	Molecular signature of kappa-carrageenan mimics chondroitin-4-sulfate and dermatan sulfate and enables interaction with arylsulfatase B.	Chondroitin Sulfates	48-69	arylsulfatase B	Homo sapiens	120-135
22079206-1	2012	The common food additive kappa-carrageenan (kappa-CGN) is a sulfated polysaccharide that resembles chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	99-120	cingulin	Homo sapiens	50-53
22079206-9	2012	By mimicry of C4S and DS and by interaction with ARSB, kappa-CGN can directly interfere with the normal cellular functions of C4S, DS and ARSB.	Chondroitin Sulfates	14-17	cingulin	Homo sapiens	61-64
22079206-1	2012	The common food additive kappa-carrageenan (kappa-CGN) is a sulfated polysaccharide that resembles chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	122-125	cingulin	Homo sapiens	50-53
22079206-9	2012	By mimicry of C4S and DS and by interaction with ARSB, kappa-CGN can directly interfere with the normal cellular functions of C4S, DS and ARSB.	Chondroitin Sulfates	14-17	arylsulfatase B	Homo sapiens	138-142
22764251-4	2012	We identify a 15 aa domain containing an arginine-lysine doublet (RK peptide) within Otx2, bearing prototypic traits of a glycosaminoglycan (GAG) binding sequence that mediates Otx2 binding to PNNs, and specifically to chondroitin sulfate D and E, with high affinity.	Chondroitin Sulfates	219-238	orthodenticle homeobox 2	Mus musculus	85-89
22582845-6	2012	The data showed increased expression of chondroitin sulfate and hyaluronic acid, after reduction as the LLLT and mature bone, resembling the expression of osteonectin and biglycan.	Chondroitin Sulfates	40-59	secreted protein acidic and cysteine rich	Rattus norvegicus	155-166
22582845-6	2012	The data showed increased expression of chondroitin sulfate and hyaluronic acid, after reduction as the LLLT and mature bone, resembling the expression of osteonectin and biglycan.	Chondroitin Sulfates	40-59	biglycan	Rattus norvegicus	171-179
22947857-8	2012	In contrast to CD44-HA binding, the molecular interaction between CD44 and fibrin(ogen) is predominantly mediated by the chondroitin sulfate and dermatan sulfate on CD44.	Chondroitin Sulfates	121-140	CD44 molecule (Indian blood group)	Homo sapiens	66-70
22947857-8	2012	In contrast to CD44-HA binding, the molecular interaction between CD44 and fibrin(ogen) is predominantly mediated by the chondroitin sulfate and dermatan sulfate on CD44.	Chondroitin Sulfates	121-140	CD44 molecule (Indian blood group)	Homo sapiens	66-70
22426137-0	2012	Sulfated hyaluronan and chondroitin sulfate derivatives interact differently with human transforming growth factor-beta1 (TGF-beta1).	Chondroitin Sulfates	24-43	transforming growth factor beta 1	Homo sapiens	88-120
22426137-0	2012	Sulfated hyaluronan and chondroitin sulfate derivatives interact differently with human transforming growth factor-beta1 (TGF-beta1).	Chondroitin Sulfates	24-43	transforming growth factor beta 1	Homo sapiens	122-131
22426137-1	2012	This study demonstrates that the modification of hyaluronan (hyaluronic acid; Hya) and chondroitin sulfate (CS) with sulfate groups leads to different binding affinities for recombinant human transforming growth factor-beta1 (TGF-beta1) for comparable average degrees of sulfation (DS).	Chondroitin Sulfates	87-106	transforming growth factor beta 1	Homo sapiens	192-224
22426137-1	2012	This study demonstrates that the modification of hyaluronan (hyaluronic acid; Hya) and chondroitin sulfate (CS) with sulfate groups leads to different binding affinities for recombinant human transforming growth factor-beta1 (TGF-beta1) for comparable average degrees of sulfation (DS).	Chondroitin Sulfates	87-106	transforming growth factor beta 1	Homo sapiens	226-235
22426137-1	2012	This study demonstrates that the modification of hyaluronan (hyaluronic acid; Hya) and chondroitin sulfate (CS) with sulfate groups leads to different binding affinities for recombinant human transforming growth factor-beta1 (TGF-beta1) for comparable average degrees of sulfation (DS).	Chondroitin Sulfates	108-110	transforming growth factor beta 1	Homo sapiens	192-224
22426137-1	2012	This study demonstrates that the modification of hyaluronan (hyaluronic acid; Hya) and chondroitin sulfate (CS) with sulfate groups leads to different binding affinities for recombinant human transforming growth factor-beta1 (TGF-beta1) for comparable average degrees of sulfation (DS).	Chondroitin Sulfates	108-110	transforming growth factor beta 1	Homo sapiens	226-235
22426137-2	2012	In general, Hya derivates showed higher binding strength than CS derivatives.	Chondroitin Sulfates	62-64	lysine demethylase 5D	Homo sapiens	12-15
22764251-4	2012	We identify a 15 aa domain containing an arginine-lysine doublet (RK peptide) within Otx2, bearing prototypic traits of a glycosaminoglycan (GAG) binding sequence that mediates Otx2 binding to PNNs, and specifically to chondroitin sulfate D and E, with high affinity.	Chondroitin Sulfates	219-238	orthodenticle homeobox 2	Mus musculus	177-181
22678705-1	2012	BACKGROUND: Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) is a clinically heterogenous congenital disorder caused by mutations in proteoglycan 4 (PRG4), a chondroitin sulfate proteoglycan that acts as a lubricant for the cartilage surface.	Chondroitin Sulfates	174-193	proteoglycan 4	Homo sapiens	71-75
22678705-1	2012	BACKGROUND: Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) is a clinically heterogenous congenital disorder caused by mutations in proteoglycan 4 (PRG4), a chondroitin sulfate proteoglycan that acts as a lubricant for the cartilage surface.	Chondroitin Sulfates	174-193	proteoglycan 4	Homo sapiens	149-163
22678705-1	2012	BACKGROUND: Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) is a clinically heterogenous congenital disorder caused by mutations in proteoglycan 4 (PRG4), a chondroitin sulfate proteoglycan that acts as a lubricant for the cartilage surface.	Chondroitin Sulfates	174-193	proteoglycan 4	Homo sapiens	165-169
22633136-10	2012	In conclusion, oral CS elicits a systemic effect but does not affect CYP1A2, CYP3A6, and CPR in control rabbits, although in rabbits with TIIR, CS prevents CYP3A6 protein down-regulation but not that of CYP1A2.	Chondroitin Sulfates	144-146	cytochrome P450 3A6	Oryctolagus cuniculus	156-162
22658154-8	2012	In contrast, enhanced RUNX2 expression was observed in the CCS scaffolds in comparison to the CHyA scaffolds suggesting an osteogenic influence of chondroitin sulphate on MSC differentiation.	Chondroitin Sulfates	147-167	RUNX family transcription factor 2	Homo sapiens	22-27
22633136-0	2012	Effect of chondroitin sulfate on turpentine-induced down-regulation of CYP1A2 and CYP3A6.	Chondroitin Sulfates	10-29	cytochrome P450 1A2	Oryctolagus cuniculus	71-77
22633136-0	2012	Effect of chondroitin sulfate on turpentine-induced down-regulation of CYP1A2 and CYP3A6.	Chondroitin Sulfates	10-29	cytochrome P450 3A6	Oryctolagus cuniculus	82-88
22633136-1	2012	This study aimed to assess whether chronic administration of chondroitin sulfate (CS) affects baseline expression of cytochrome P450 isoforms and impedes the decrease in expression and activity of CYP1A2 and CYP3A6 in rabbits with a turpentine-induced inflammatory reaction (TIIR).	Chondroitin Sulfates	61-80	cytochrome P450 1A2	Oryctolagus cuniculus	197-203
22633136-1	2012	This study aimed to assess whether chronic administration of chondroitin sulfate (CS) affects baseline expression of cytochrome P450 isoforms and impedes the decrease in expression and activity of CYP1A2 and CYP3A6 in rabbits with a turpentine-induced inflammatory reaction (TIIR).	Chondroitin Sulfates	61-80	cytochrome P450 3A6	Oryctolagus cuniculus	208-214
22633136-1	2012	This study aimed to assess whether chronic administration of chondroitin sulfate (CS) affects baseline expression of cytochrome P450 isoforms and impedes the decrease in expression and activity of CYP1A2 and CYP3A6 in rabbits with a turpentine-induced inflammatory reaction (TIIR).	Chondroitin Sulfates	82-84	cytochrome P450 1A2	Oryctolagus cuniculus	197-203
22633136-1	2012	This study aimed to assess whether chronic administration of chondroitin sulfate (CS) affects baseline expression of cytochrome P450 isoforms and impedes the decrease in expression and activity of CYP1A2 and CYP3A6 in rabbits with a turpentine-induced inflammatory reaction (TIIR).	Chondroitin Sulfates	82-84	cytochrome P450 3A6	Oryctolagus cuniculus	208-214
22633136-6	2012	In rabbits with TIIR, CS prevented the decrease of CYP3A6 expression but not the reduction in activity.	Chondroitin Sulfates	22-24	cytochrome P450 3A6	Oryctolagus cuniculus	51-57
22456539-1	2012	The accumulated mucin in non-Gottron"s dermatomyositis (DM) lesions is primarily chondroitin-4-sulfate (C4S), which is immunomodulatory in vitro.	Chondroitin Sulfates	81-102	LOC100508689	Homo sapiens	16-21
22456539-1	2012	The accumulated mucin in non-Gottron"s dermatomyositis (DM) lesions is primarily chondroitin-4-sulfate (C4S), which is immunomodulatory in vitro.	Chondroitin Sulfates	104-107	LOC100508689	Homo sapiens	16-21
22543042-3	2012	To do this bone morphogenetic protein-2 (BMP-2) nanocomplex (NC) was fabricated by using an ionic interaction between BMP-2 and chondroitin sulfate (CS).	Chondroitin Sulfates	149-151	bone morphogenetic protein 2	Mus musculus	41-46
22543042-3	2012	To do this bone morphogenetic protein-2 (BMP-2) nanocomplex (NC) was fabricated by using an ionic interaction between BMP-2 and chondroitin sulfate (CS).	Chondroitin Sulfates	128-147	bone morphogenetic protein 2	Mus musculus	11-39
22543042-3	2012	To do this bone morphogenetic protein-2 (BMP-2) nanocomplex (NC) was fabricated by using an ionic interaction between BMP-2 and chondroitin sulfate (CS).	Chondroitin Sulfates	149-151	bone morphogenetic protein 2	Mus musculus	118-123
22543042-3	2012	To do this bone morphogenetic protein-2 (BMP-2) nanocomplex (NC) was fabricated by using an ionic interaction between BMP-2 and chondroitin sulfate (CS).	Chondroitin Sulfates	128-147	bone morphogenetic protein 2	Mus musculus	41-46
22156920-4	2012	We synthesized a series of sulfated and unsulfated analogs of the linkage oligosaccharide and of the constitutive unit of CS and tested these molecules as potential acceptor substrates for the recombinant human CSGalNAcT-1.	Chondroitin Sulfates	122-124	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	211-222
22543042-3	2012	To do this bone morphogenetic protein-2 (BMP-2) nanocomplex (NC) was fabricated by using an ionic interaction between BMP-2 and chondroitin sulfate (CS).	Chondroitin Sulfates	149-151	bone morphogenetic protein 2	Mus musculus	11-39
22528482-2	2012	The complex is covalently held together by chondroitin sulfate but during inflammation IalphaI may interact with TNF-stimulated gene 6 protein (TSG-6), which supports transesterification of heavy chains to hyaluronan.	Chondroitin Sulfates	43-62	TNF alpha induced protein 6	Homo sapiens	144-149
22410212-8	2012	Study results suggest that carrageenan inhibition of sulfatase activity leads to re-distribution of the cellular GAG composition with increase in di-sulfated CS and with potential consequences for cell structure and function.	Chondroitin Sulfates	158-160	arylsulfatase family member H	Homo sapiens	53-62
22493510-5	2012	In this study the receptor molecule for CS chains containing E-disaccharides expressed on LLC cells was revealed to be receptor for advanced glycation end products (RAGE), which is a member of the immunoglobulin superfamily predominantly expressed in the lung.	Chondroitin Sulfates	40-42	advanced glycosylation end product-specific receptor	Mus musculus	165-169
22493510-7	2012	Furthermore, the colonization of the lungs by LLC cells was effectively inhibited by the blocking of CS or HS chains at the tumor cell surface with an anti-RAGE antibody through intravenous injections in a dose-dependent manner.	Chondroitin Sulfates	101-103	advanced glycosylation end product-specific receptor	Mus musculus	156-160
22493510-8	2012	These results provide the clear evidence that RAGE is at least one of the critical receptors for CS and HS chains expressed at the tumor cell surface and involved in experimental lung metastasis and that CS/HS and RAGE are potential molecular targets in the treatment of pulmonary metastasis.	Chondroitin Sulfates	97-99	advanced glycosylation end product-specific receptor	Mus musculus	46-50
22493510-8	2012	These results provide the clear evidence that RAGE is at least one of the critical receptors for CS and HS chains expressed at the tumor cell surface and involved in experimental lung metastasis and that CS/HS and RAGE are potential molecular targets in the treatment of pulmonary metastasis.	Chondroitin Sulfates	204-206	advanced glycosylation end product-specific receptor	Mus musculus	46-50
22203690-12	2012	Our study shows how, from the three CS compounds tested, CS1 induces the activation of inflammatory and catabolic pathways, whereas CS2 and CS3 induce an anti-inflammatory and anabolic response.	Chondroitin Sulfates	36-38	myozenin 2	Homo sapiens	57-60
22203690-12	2012	Our study shows how, from the three CS compounds tested, CS1 induces the activation of inflammatory and catabolic pathways, whereas CS2 and CS3 induce an anti-inflammatory and anabolic response.	Chondroitin Sulfates	36-38	chorionic somatomammotropin hormone 2	Homo sapiens	132-135
22342947-1	2012	Here, we report the fluorometric detection of protein kinase Calpha (PKCalpha) activity in a cancerous cell lysate using a polyion complex (PIC) composed of a quencher (BHQ3)-modified chondroitin sulfate [CS(X)] and a dendrimer modified with a cationic peptide substrate (FKKQGSFAKKK-NH(2)) and a near infrared (NIR) fluorophore (Cy5.5) (polymer 1).	Chondroitin Sulfates	184-203	protein kinase C alpha	Homo sapiens	46-67
22342947-1	2012	Here, we report the fluorometric detection of protein kinase Calpha (PKCalpha) activity in a cancerous cell lysate using a polyion complex (PIC) composed of a quencher (BHQ3)-modified chondroitin sulfate [CS(X)] and a dendrimer modified with a cationic peptide substrate (FKKQGSFAKKK-NH(2)) and a near infrared (NIR) fluorophore (Cy5.5) (polymer 1).	Chondroitin Sulfates	184-203	protein kinase C alpha	Homo sapiens	69-77
22451654-0	2012	Hyaluronidase 1 and beta-hexosaminidase have redundant functions in hyaluronan and chondroitin sulfate degradation.	Chondroitin Sulfates	83-102	hyaluronoglucosaminidase 1	Mus musculus	0-15
22451654-0	2012	Hyaluronidase 1 and beta-hexosaminidase have redundant functions in hyaluronan and chondroitin sulfate degradation.	Chondroitin Sulfates	83-102	O-GlcNAcase	Mus musculus	20-39
22451654-8	2012	Accumulation of chondroitin sulfate derivatives was detected in mice deficient in both enzymes, as well as in beta-hexosaminidase-deficient mice, indicating that both enzymes play a significant role in chondroitin sulfate breakdown.	Chondroitin Sulfates	202-221	O-GlcNAcase	Mus musculus	110-129
22451654-10	2012	Furthermore, accumulation of sulfated chondroitin in tissues provides in vivo evidence that both HYAL1 and beta-hexosaminidase cleave chondroitin sulfate, but it is a preferred substrate for beta-hexosaminidase.	Chondroitin Sulfates	134-153	hyaluronoglucosaminidase 1	Mus musculus	97-102
22451654-10	2012	Furthermore, accumulation of sulfated chondroitin in tissues provides in vivo evidence that both HYAL1 and beta-hexosaminidase cleave chondroitin sulfate, but it is a preferred substrate for beta-hexosaminidase.	Chondroitin Sulfates	134-153	O-GlcNAcase	Mus musculus	107-126
22345168-4	2012	Cells unable to produce heparan sulfate instead increase their production of chondroitin sulfate that binds key angiogenic growth factors such as vascular endothelial growth factor A, transforming growth factor beta, and platelet-derived growth factor B.	Chondroitin Sulfates	77-96	vascular endothelial growth factor A	Mus musculus	146-215
22058013-0	2012	Long-term oral administration of glucosamine or chondroitin sulfate reduces destruction of cartilage and up-regulation of MMP-3 mRNA in a model of spontaneous osteoarthritis in Hartley guinea pigs.	Chondroitin Sulfates	48-67	stromelysin-1	Cavia porcellus	122-127
22058013-7	2012	Thus, long-term oral administration of GlcN or CS inhibits OA progression, maintains total RNA and down-regulates MMP-3 mRNA in a spontaneous OA model in Hartley guinea pigs.	Chondroitin Sulfates	47-49	stromelysin-1	Cavia porcellus	114-119
22389491-0	2012	Chondroitin sulfate proteoglycans down-regulate spine formation in cortical neurons by targeting tropomyosin-related kinase B (TrkB) protein.	Chondroitin Sulfates	0-19	neurotrophic receptor tyrosine kinase 2	Homo sapiens	97-125
22389491-0	2012	Chondroitin sulfate proteoglycans down-regulate spine formation in cortical neurons by targeting tropomyosin-related kinase B (TrkB) protein.	Chondroitin Sulfates	0-19	neurotrophic receptor tyrosine kinase 2	Homo sapiens	127-131
22156920-0	2012	Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) involved in chondroitin sulfate initiation: Impact of sulfation on activity and specificity.	Chondroitin Sulfates	82-101	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	0-55
22156920-0	2012	Chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) involved in chondroitin sulfate initiation: Impact of sulfation on activity and specificity.	Chondroitin Sulfates	82-101	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	57-68
22156920-3	2012	To investigate this, we determined whether sulfate substitution of galactose (Gal) residues of the linkage region or of N-acetylgalactosamine (GalNAc) of the disaccharide unit influences activity and specificity of chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1), a key glycosyltransferase of CS biosynthesis.	Chondroitin Sulfates	272-274	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Homo sapiens	215-270
22521955-2	2012	The pathology is due to a deficient activity of N-acetylgalactosamine-6-sulfate-sulfatase, which is involved in the degradation of keratan sulfate and chondroitin-6-sulfate.	Chondroitin Sulfates	151-172	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	48-89
22822386-4	2012	Atomic model assessment of the CTSK gene revealed that the R122P mutant could disrupt hydrogen bonds binding with chondroitin 4-sulfate leading to a decrease in the collagen-degrading activity of cathepsin K.	Chondroitin Sulfates	114-135	cathepsin K	Homo sapiens	31-35
22822386-4	2012	Atomic model assessment of the CTSK gene revealed that the R122P mutant could disrupt hydrogen bonds binding with chondroitin 4-sulfate leading to a decrease in the collagen-degrading activity of cathepsin K.	Chondroitin Sulfates	114-135	cathepsin K	Homo sapiens	196-207
22190409-2	2012	Previous studies have shown that the matrix chondroitin sulfate proteoglycan, versican, exhibits a similar pattern of expression in the embryonic joint rudiment of chick and mouse suggesting conserved function during joint development.	Chondroitin Sulfates	44-63	versican	Gallus gallus	78-86
22179028-0	2012	A potential role of chondroitin sulfate on bone in osteoarthritis: inhibition of prostaglandin E2 and matrix metalloproteinases synthesis in interleukin-1beta-stimulated osteoblasts.	Chondroitin Sulfates	20-39	interleukin 1 beta	Mus musculus	141-158
22228506-4	2012	METHODS: Plasmid harboring the gene of murine granulocyte macrophage-colony-stimulating factor (mGM-CSF) was complexed with polyethyleneimine (PEI) and hyaluronic acid or chondroitin sulfate.	Chondroitin Sulfates	171-190	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	96-103
22228506-9	2012	Intraperitoneal injection of mGM-CSF/PEI coated with 10-kDa chondroitin sulfate prolonged survival compared to that coated with hyaluronic acid.	Chondroitin Sulfates	60-79	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	29-40
22228506-10	2012	Intratumoral injection of mGM-CSF/PEI coated with 10-kDa chondroitin sulfate achieved mouse survival rates of 100%, although that with hyaluronic acid did not.	Chondroitin Sulfates	57-76	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	26-37
22228506-11	2012	CONCLUSIONS: These findings suggest that GM-CSF/PEI coated with 10-kDa chondroitin sulfate has the potential for use in gene therapy of ovarian cancer.	Chondroitin Sulfates	71-90	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	41-47
22052369-6	2012	We have also found that CS/GEM combination induced a strong potentiation             of apoptosis with the consequent activation of caspases 9 and 3.	Chondroitin Sulfates	24-26	caspase 9	Homo sapiens	132-148
22179028-1	2012	OBJECTIVES: To determine the effect of chondroitin sulfate (CS) on inflammatory mediators and proteolytic enzymes induced by interleukin-1beta (IL-1beta) and related to cartilage catabolism in murine osteoblasts.	Chondroitin Sulfates	39-58	interleukin 1 beta	Mus musculus	125-142
22179028-1	2012	OBJECTIVES: To determine the effect of chondroitin sulfate (CS) on inflammatory mediators and proteolytic enzymes induced by interleukin-1beta (IL-1beta) and related to cartilage catabolism in murine osteoblasts.	Chondroitin Sulfates	39-58	interleukin 1 beta	Mus musculus	144-152
22179028-1	2012	OBJECTIVES: To determine the effect of chondroitin sulfate (CS) on inflammatory mediators and proteolytic enzymes induced by interleukin-1beta (IL-1beta) and related to cartilage catabolism in murine osteoblasts.	Chondroitin Sulfates	60-62	interleukin 1 beta	Mus musculus	125-142
22179028-1	2012	OBJECTIVES: To determine the effect of chondroitin sulfate (CS) on inflammatory mediators and proteolytic enzymes induced by interleukin-1beta (IL-1beta) and related to cartilage catabolism in murine osteoblasts.	Chondroitin Sulfates	60-62	interleukin 1 beta	Mus musculus	144-152
22179028-7	2012	Interestingly, 7 days of CS treatment significantly counteracted IL-1beta-induced expression of COX-2 (-62%, P&lt;0.001), mPGES-1 (-63%, P&lt;0.001), MMP-3 (-39%, P=0.08), MMP-13 (-60%, P&lt;0.001) and RANKL (-84%, P&lt;0.001).	Chondroitin Sulfates	25-27	interleukin 1 beta	Mus musculus	65-73
22179028-7	2012	Interestingly, 7 days of CS treatment significantly counteracted IL-1beta-induced expression of COX-2 (-62%, P&lt;0.001), mPGES-1 (-63%, P&lt;0.001), MMP-3 (-39%, P=0.08), MMP-13 (-60%, P&lt;0.001) and RANKL (-84%, P&lt;0.001).	Chondroitin Sulfates	25-27	prostaglandin-endoperoxide synthase 2	Mus musculus	96-101
22179028-7	2012	Interestingly, 7 days of CS treatment significantly counteracted IL-1beta-induced expression of COX-2 (-62%, P&lt;0.001), mPGES-1 (-63%, P&lt;0.001), MMP-3 (-39%, P=0.08), MMP-13 (-60%, P&lt;0.001) and RANKL (-84%, P&lt;0.001).	Chondroitin Sulfates	25-27	prostaglandin E synthase	Mus musculus	122-129
22179028-7	2012	Interestingly, 7 days of CS treatment significantly counteracted IL-1beta-induced expression of COX-2 (-62%, P&lt;0.001), mPGES-1 (-63%, P&lt;0.001), MMP-3 (-39%, P=0.08), MMP-13 (-60%, P&lt;0.001) and RANKL (-84%, P&lt;0.001).	Chondroitin Sulfates	25-27	matrix metallopeptidase 3	Mus musculus	150-155
22179028-7	2012	Interestingly, 7 days of CS treatment significantly counteracted IL-1beta-induced expression of COX-2 (-62%, P&lt;0.001), mPGES-1 (-63%, P&lt;0.001), MMP-3 (-39%, P=0.08), MMP-13 (-60%, P&lt;0.001) and RANKL (-84%, P&lt;0.001).	Chondroitin Sulfates	25-27	matrix metallopeptidase 13	Mus musculus	172-178
22179028-7	2012	Interestingly, 7 days of CS treatment significantly counteracted IL-1beta-induced expression of COX-2 (-62%, P&lt;0.001), mPGES-1 (-63%, P&lt;0.001), MMP-3 (-39%, P=0.08), MMP-13 (-60%, P&lt;0.001) and RANKL (-84%, P&lt;0.001).	Chondroitin Sulfates	25-27	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	202-207
21942880-0	2012	Chondroitin 4-O-sulfotransferase-2 regulates the number of chondroitin sulfate chains initiated by chondroitin N-acetylgalactosaminyltransferase-1.	Chondroitin Sulfates	59-78	carbohydrate sulfotransferase 12	Mus musculus	0-34
22001376-1	2012	Biglycan (BGN) is a small proteoglycan that consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains of either chondroitin sulfate (CS) or dermatan sulfate (DS) type.	Chondroitin Sulfates	159-178	biglycan	Homo sapiens	0-8
22001376-1	2012	Biglycan (BGN) is a small proteoglycan that consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains of either chondroitin sulfate (CS) or dermatan sulfate (DS) type.	Chondroitin Sulfates	159-178	biglycan	Homo sapiens	10-13
22001376-1	2012	Biglycan (BGN) is a small proteoglycan that consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains of either chondroitin sulfate (CS) or dermatan sulfate (DS) type.	Chondroitin Sulfates	180-182	biglycan	Homo sapiens	0-8
22001376-1	2012	Biglycan (BGN) is a small proteoglycan that consists of a protein core containing leucine-rich repeat regions and two glycosaminoglycan (GAG) chains of either chondroitin sulfate (CS) or dermatan sulfate (DS) type.	Chondroitin Sulfates	180-182	biglycan	Homo sapiens	10-13
22001376-2	2012	The development of novel, highly efficient analytical methods for structural identification of BGN-derived CS/DS motifs, possibly implicated in biological events, is currently the focus of research.	Chondroitin Sulfates	107-109	biglycan	Homo sapiens	95-98
22001376-4	2012	The CS/DS chains were released from transfected 293 BGN by beta-elimination.	Chondroitin Sulfates	4-6	biglycan	Homo sapiens	52-55
21942880-6	2012	In addition, C4ST-2 (chondroitin 4-O-sulfotransferase-2) efficiently transferred sulfate from 3"-phosphoadenosine 5"-phosphosulfate to position 4 of non-reducing terminal GalNAc-linkage residues, and the number of CS chains was regulated by the expression levels of C4ST-2 and of ChGn-1.	Chondroitin Sulfates	214-216	carbohydrate sulfotransferase 12	Mus musculus	13-19
21942880-6	2012	In addition, C4ST-2 (chondroitin 4-O-sulfotransferase-2) efficiently transferred sulfate from 3"-phosphoadenosine 5"-phosphosulfate to position 4 of non-reducing terminal GalNAc-linkage residues, and the number of CS chains was regulated by the expression levels of C4ST-2 and of ChGn-1.	Chondroitin Sulfates	214-216	carbohydrate sulfotransferase 12	Mus musculus	21-55
21942880-7	2012	Taken together, the results of the present study indicate that C4ST-2 plays a key role in regulating levels of CS synthesized via ChGn-1.	Chondroitin Sulfates	111-113	carbohydrate sulfotransferase 12	Mus musculus	63-69
21948369-3	2012	Chondroitin sulfate A (CS-A), released from alpha granules during platelet activation, is a potent mediator of crosstalk between platelets and the complement system.	Chondroitin Sulfates	0-21	chorionic somatomammotropin hormone 1	Homo sapiens	23-27
22122859-1	2012	A vaccine protecting women against placental malaria could be based on the sub-domains of the VAR2CSA antigen, since antibodies against the DBL4e-ID4 subunit of the VAR2CSA protein can inhibit parasite binding to the placental ligand chondroitin sulphate A (CSA).	Chondroitin Sulfates	234-256	inhibitor of DNA binding 4, HLH protein	Homo sapiens	140-149
22122859-1	2012	A vaccine protecting women against placental malaria could be based on the sub-domains of the VAR2CSA antigen, since antibodies against the DBL4e-ID4 subunit of the VAR2CSA protein can inhibit parasite binding to the placental ligand chondroitin sulphate A (CSA).	Chondroitin Sulfates	98-101	inhibitor of DNA binding 4, HLH protein	Homo sapiens	140-149
22122859-4	2012	Antibodies induced against DBL4e-ID4 in combination with these adjuvants inhibited parasite binding to CSA from 82% to 99%.	Chondroitin Sulfates	103-106	inhibitor of DNA binding 4, HLH protein	Homo sapiens	27-36
22085638-6	2012	These results further demonstrate that while IL-7 is principally a heparin/heparan sulfate binding protein, it also interacts with dermatan sulfate, chondroitin sulfates C, D, and E, indicating that this cytokine preferentially interacts with GAGs having a higher degree of sulfation.	Chondroitin Sulfates	149-169	interleukin 7	Mus musculus	45-49
22252626-1	2012	Versican, a chondroitin sulfate proteoglycan, is one of the main components of the extracellular matrix and is considered to be crucial to several key cellular processes involved in development and disease.	Chondroitin Sulfates	12-31	versican	Homo sapiens	0-8
21966936-3	2012	Lubricin was detected as a major band at approximately 360 kDa which co-migrated in sodium dodecyl sulfate-polyacrylamide gel electrophoresis with a chondroitin sulfate (CS)-containing proteoglycan that was detected by both monoclonal antibodies (MAb) 2-B-6 and MAb 3-B-3 after chondroitinase ABC treatment and keratan sulfate (KS) that was detected by MAb 5-D-4.	Chondroitin Sulfates	149-168	proteoglycan 4	Homo sapiens	0-8
21966936-3	2012	Lubricin was detected as a major band at approximately 360 kDa which co-migrated in sodium dodecyl sulfate-polyacrylamide gel electrophoresis with a chondroitin sulfate (CS)-containing proteoglycan that was detected by both monoclonal antibodies (MAb) 2-B-6 and MAb 3-B-3 after chondroitinase ABC treatment and keratan sulfate (KS) that was detected by MAb 5-D-4.	Chondroitin Sulfates	170-172	proteoglycan 4	Homo sapiens	0-8
21966936-5	2012	Lubricin present in fractions that also contained CS was found to be decorated with CS structures which were reactive with MAb 3-B-3 after chondroitinase ABC digestion using a sandwich enzyme-linked immunosorbent assay approach.	Chondroitin Sulfates	50-52	proteoglycan 4	Homo sapiens	0-8
21966936-5	2012	Lubricin present in fractions that also contained CS was found to be decorated with CS structures which were reactive with MAb 3-B-3 after chondroitinase ABC digestion using a sandwich enzyme-linked immunosorbent assay approach.	Chondroitin Sulfates	50-52	immunoglobulin kappa variable 4-1	Homo sapiens	129-132
21966936-5	2012	Lubricin present in fractions that also contained CS was found to be decorated with CS structures which were reactive with MAb 3-B-3 after chondroitinase ABC digestion using a sandwich enzyme-linked immunosorbent assay approach.	Chondroitin Sulfates	84-86	proteoglycan 4	Homo sapiens	0-8
21966936-5	2012	Lubricin present in fractions that also contained CS was found to be decorated with CS structures which were reactive with MAb 3-B-3 after chondroitinase ABC digestion using a sandwich enzyme-linked immunosorbent assay approach.	Chondroitin Sulfates	84-86	immunoglobulin kappa variable 4-1	Homo sapiens	129-132
22252637-1	2012	Serglycin is a proteoglycan composed of a relatively small (~17 kDa) core protein to which sulfated glycosaminoglycans of either heparin, heparan sulfate or chondroitin sulfate types are attached.	Chondroitin Sulfates	157-176	serglycin	Mus musculus	0-9
22252645-8	2012	Transfection of chondrocytes or cartilage explants by the expression vector for the glycosyltransferase beta-1,3-glucuronosyltransferase-I (GlcAT-I) enhanced PG synthesis and deposition in the ECM by promoting the synthesis of chondroitin sulfate GAG chains of the cartilage matrix.	Chondroitin Sulfates	227-246	beta-1,3-glucuronyltransferase 3	Homo sapiens	84-138
22252645-8	2012	Transfection of chondrocytes or cartilage explants by the expression vector for the glycosyltransferase beta-1,3-glucuronosyltransferase-I (GlcAT-I) enhanced PG synthesis and deposition in the ECM by promoting the synthesis of chondroitin sulfate GAG chains of the cartilage matrix.	Chondroitin Sulfates	227-246	beta-1,3-glucuronyltransferase 3	Homo sapiens	140-147
22952769-0	2012	Chondroitin sulfate synthase-2 is necessary for chain extension of chondroitin sulfate but not critical for skeletal development.	Chondroitin Sulfates	67-86	chondroitin polymerizing factor	Mus musculus	0-30
21858682-6	2012	The ECM protein laminin (lam) and chondroitin sulfate (ChS) modulated the ecto-5"-NT/CD73 activity and glioma adhesion in a parallel manner, suggesting the involvement of purinergic signaling in the effects mediated by the extracellular matrix.	Chondroitin Sulfates	34-53	5'-nucleotidase ecto	Homo sapiens	85-89
21858682-6	2012	The ECM protein laminin (lam) and chondroitin sulfate (ChS) modulated the ecto-5"-NT/CD73 activity and glioma adhesion in a parallel manner, suggesting the involvement of purinergic signaling in the effects mediated by the extracellular matrix.	Chondroitin Sulfates	55-58	multimerin 1	Homo sapiens	4-7
21858682-6	2012	The ECM protein laminin (lam) and chondroitin sulfate (ChS) modulated the ecto-5"-NT/CD73 activity and glioma adhesion in a parallel manner, suggesting the involvement of purinergic signaling in the effects mediated by the extracellular matrix.	Chondroitin Sulfates	55-58	5'-nucleotidase ecto	Homo sapiens	85-89
22428001-2	2012	ARSB removes 4-sulfate groups from the non-reducing end of chondroitin-4-sulfate and dermatan sulfate and is required for their degradation.	Chondroitin Sulfates	59-80	arylsulfatase B	Homo sapiens	0-4
22479647-11	2012	Moreover, a significant loss of cells in the ganglion cell layer, and Thy-1-, NeuN- and Brn3a- positive cells was observed in eyes injected with CS, whereas RON significantly preserved these parameters.	Chondroitin Sulfates	145-147	Thy-1 cell surface antigen	Rattus norvegicus	70-75
22479647-11	2012	Moreover, a significant loss of cells in the ganglion cell layer, and Thy-1-, NeuN- and Brn3a- positive cells was observed in eyes injected with CS, whereas RON significantly preserved these parameters.	Chondroitin Sulfates	145-147	RNA binding fox-1 homolog 3	Rattus norvegicus	78-82
22479647-11	2012	Moreover, a significant loss of cells in the ganglion cell layer, and Thy-1-, NeuN- and Brn3a- positive cells was observed in eyes injected with CS, whereas RON significantly preserved these parameters.	Chondroitin Sulfates	145-147	POU class 4 homeobox 1	Rattus norvegicus	88-93
22428001-7	2012	Hypoxia, like ARSB silencing, significantly increased the total cellular sulfated glycosaminoglycans and chondroitin-4-sulfate (C4S) content.	Chondroitin Sulfates	105-126	arylsulfatase B	Homo sapiens	14-18
22428001-7	2012	Hypoxia, like ARSB silencing, significantly increased the total cellular sulfated glycosaminoglycans and chondroitin-4-sulfate (C4S) content.	Chondroitin Sulfates	128-131	arylsulfatase B	Homo sapiens	14-18
22242148-5	2012	Secreted SRPX2 protein was also detected using an anti-chondroitin sulfate antibody.	Chondroitin Sulfates	55-74	sushi repeat containing protein X-linked 2	Homo sapiens	9-14
22295099-2	2012	We are studying the causes and effects of obesity in C57Bl/6 mice following genetic ablation of NG2, a chondroitin sulfate proteoglycan widely expressed in progenitor cells and also in adipocytes.	Chondroitin Sulfates	103-122	chondroitin sulfate proteoglycan 4	Mus musculus	96-99
22042237-6	2011	Finally, several in vitro studies have focused on the hypothesis that CS may reduce inflammatory processes by acting on the nuclear translocation of NF-kappaB, which is closely associated with the blood biomarkers of inflammation, primarily IL-1, IL-6 and C-reactive protein.	Chondroitin Sulfates	70-72	nuclear factor kappa B subunit 1	Homo sapiens	149-158
22042237-6	2011	Finally, several in vitro studies have focused on the hypothesis that CS may reduce inflammatory processes by acting on the nuclear translocation of NF-kappaB, which is closely associated with the blood biomarkers of inflammation, primarily IL-1, IL-6 and C-reactive protein.	Chondroitin Sulfates	70-72	interleukin 1 alpha	Homo sapiens	241-245
22042237-6	2011	Finally, several in vitro studies have focused on the hypothesis that CS may reduce inflammatory processes by acting on the nuclear translocation of NF-kappaB, which is closely associated with the blood biomarkers of inflammation, primarily IL-1, IL-6 and C-reactive protein.	Chondroitin Sulfates	70-72	interleukin 6	Homo sapiens	247-251
22108818-1	2011	NG2 cells are a novel distinct class of central nervous system (CNS) glial cells, characterized by the expression of the chondroitin sulfate proteoglycan NG2.	Chondroitin Sulfates	121-140	chondroitin sulfate proteoglycan 4	Homo sapiens	0-3
22108818-1	2011	NG2 cells are a novel distinct class of central nervous system (CNS) glial cells, characterized by the expression of the chondroitin sulfate proteoglycan NG2.	Chondroitin Sulfates	121-140	chondroitin sulfate proteoglycan 4	Homo sapiens	154-157
22020094-0	2011	Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulin.	Chondroitin Sulfates	134-153	carbohydrate sulfotransferase 10	Homo sapiens	63-85
22020094-0	2011	Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulin.	Chondroitin Sulfates	134-153	thrombomodulin	Homo sapiens	163-177
22020094-5	2011	We also demonstrated that HNK-1ST caused the suppression of chondroitin sulfate (CS) synthesis on TM and a reduction of its anti-coagulant activity.	Chondroitin Sulfates	60-79	carbohydrate sulfotransferase 10	Homo sapiens	26-33
22020094-5	2011	We also demonstrated that HNK-1ST caused the suppression of chondroitin sulfate (CS) synthesis on TM and a reduction of its anti-coagulant activity.	Chondroitin Sulfates	81-83	carbohydrate sulfotransferase 10	Homo sapiens	26-33
22020094-7	2011	These results suggest that HNK-1ST is involved in 3-O-sulfation of the terminal GlcA of the linkage tetrasaccharide which acts as an inhibitory signal for the initiation of CS biosynthesis on TM.	Chondroitin Sulfates	173-175	carbohydrate sulfotransferase 10	Homo sapiens	27-34
21482159-1	2011	Chondroitin sulfate proteoglycan-4 (CSPG4), also known as high molecular weight-melanoma associated antigen (HMW-MAA), is a membrane-bound chondroitin sulfate proteoglycan highly expressed by human melanoma cells.	Chondroitin Sulfates	139-158	chondroitin sulfate proteoglycan 4	Homo sapiens	0-34
21482159-1	2011	Chondroitin sulfate proteoglycan-4 (CSPG4), also known as high molecular weight-melanoma associated antigen (HMW-MAA), is a membrane-bound chondroitin sulfate proteoglycan highly expressed by human melanoma cells.	Chondroitin Sulfates	139-158	chondroitin sulfate proteoglycan 4	Homo sapiens	36-41
21482159-1	2011	Chondroitin sulfate proteoglycan-4 (CSPG4), also known as high molecular weight-melanoma associated antigen (HMW-MAA), is a membrane-bound chondroitin sulfate proteoglycan highly expressed by human melanoma cells.	Chondroitin Sulfates	139-158	chondroitin sulfate proteoglycan 4	Homo sapiens	58-107
21482159-1	2011	Chondroitin sulfate proteoglycan-4 (CSPG4), also known as high molecular weight-melanoma associated antigen (HMW-MAA), is a membrane-bound chondroitin sulfate proteoglycan highly expressed by human melanoma cells.	Chondroitin Sulfates	139-158	chondroitin sulfate proteoglycan 4	Homo sapiens	109-116
22008685-1	2011	OBJECTIVE: To construct a new 3D porous bone substitute material with collagen, hydroxyapatite and chondroitin sulfate, which has the main components of nature bone and the cell growth factor BMP-2 with bone inductive ability.	Chondroitin Sulfates	99-118	bone morphogenetic protein 2	Rattus norvegicus	192-197
21882808-3	2011	Addition of heparin into TFP solution significantly minimizes the fluorescence quenching of GO toward TFP, which is less effective for the heparin analogues, such as hyaluronic acid and chondroitin 4-sulfate.	Chondroitin Sulfates	186-207	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	25-28
22039610-1	2011	Three isomers of chondroitin sulfate (CS), i.e., CS-A, CS-B, and CS-C, are investigated as nanotube dispersants and are found to have vastly different abilities to disperse single-walled carbon nanotubes (SWNTs) in water due to their different intramolecular interactions.	Chondroitin Sulfates	17-36	chorionic somatomammotropin hormone 1	Homo sapiens	49-53
21872562-4	2011	Infiltrating T cells specific for myelin proteolipid protein stimulated proliferation of chondroitin sulfate NG2-expressing oligodendrocyte precursor cells early after induction via axonal transection, resulting in a 25% increase in the numbers of oligodendrocytes.	Chondroitin Sulfates	89-108	proteolipid protein (myelin) 1	Mus musculus	34-60
21872562-4	2011	Infiltrating T cells specific for myelin proteolipid protein stimulated proliferation of chondroitin sulfate NG2-expressing oligodendrocyte precursor cells early after induction via axonal transection, resulting in a 25% increase in the numbers of oligodendrocytes.	Chondroitin Sulfates	89-108	chondroitin sulfate proteoglycan 4	Mus musculus	109-112
22039610-1	2011	Three isomers of chondroitin sulfate (CS), i.e., CS-A, CS-B, and CS-C, are investigated as nanotube dispersants and are found to have vastly different abilities to disperse single-walled carbon nanotubes (SWNTs) in water due to their different intramolecular interactions.	Chondroitin Sulfates	17-36	chorionic somatomammotropin hormone 2	Homo sapiens	55-59
22039610-1	2011	Three isomers of chondroitin sulfate (CS), i.e., CS-A, CS-B, and CS-C, are investigated as nanotube dispersants and are found to have vastly different abilities to disperse single-walled carbon nanotubes (SWNTs) in water due to their different intramolecular interactions.	Chondroitin Sulfates	38-40	chorionic somatomammotropin hormone 1	Homo sapiens	49-53
22039610-1	2011	Three isomers of chondroitin sulfate (CS), i.e., CS-A, CS-B, and CS-C, are investigated as nanotube dispersants and are found to have vastly different abilities to disperse single-walled carbon nanotubes (SWNTs) in water due to their different intramolecular interactions.	Chondroitin Sulfates	38-40	chorionic somatomammotropin hormone 2	Homo sapiens	55-59
21804177-4	2011	It was also revealed that nerve growth factor exhibits a slightly stronger affinity for hyaluronic acid than for chondroitin sulfate.	Chondroitin Sulfates	113-132	nerve growth factor	Homo sapiens	26-45
21804177-5	2011	However, E8 chick dorsal root ganglia cultured in the presence of nerve growth factor revealed that ganglia cultured in chondroitin sulfate scaffolds showed more robust growth than those cultured in control gels of hyaluronic acid.	Chondroitin Sulfates	120-139	nerve growth factor	Gallus gallus	66-85
21772054-4	2011	Tetrameric PF4 potentiates aPC generation by formation of complexes with chondroitin sulfate (CS) on TM.	Chondroitin Sulfates	73-92	platelet factor 4	Homo sapiens	11-14
21792394-2	2011	As a consequence of the conversion of chondroitin sulfate (CS) to dermatan sulfate (DS), the glycosaminoglycans become more flexible and enable DS to perform more sophisticated signaling functions.	Chondroitin Sulfates	38-57	colony stimulating factor 1	Homo sapiens	59-61
21828042-7	2011	Intriguingly, the HNK-1 antibody recognized CS chains and the linkage region if they contained GlcUA(3-O-sulfate), suggesting that HNK-1ST not only synthesizes the HNK-1 epitope but may also be involved in the generation of part-time PGs.	Chondroitin Sulfates	44-46	beta-1,3-glucuronyltransferase 1	Homo sapiens	18-23
21828042-7	2011	Intriguingly, the HNK-1 antibody recognized CS chains and the linkage region if they contained GlcUA(3-O-sulfate), suggesting that HNK-1ST not only synthesizes the HNK-1 epitope but may also be involved in the generation of part-time PGs.	Chondroitin Sulfates	44-46	carbohydrate sulfotransferase 10	Homo sapiens	131-138
21828042-7	2011	Intriguingly, the HNK-1 antibody recognized CS chains and the linkage region if they contained GlcUA(3-O-sulfate), suggesting that HNK-1ST not only synthesizes the HNK-1 epitope but may also be involved in the generation of part-time PGs.	Chondroitin Sulfates	44-46	beta-1,3-glucuronyltransferase 1	Homo sapiens	131-136
21772054-4	2011	Tetrameric PF4 potentiates aPC generation by formation of complexes with chondroitin sulfate (CS) on TM.	Chondroitin Sulfates	94-96	platelet factor 4	Homo sapiens	11-14
21772054-9	2011	Our studies provide evidence that complexes formed between PF4 and TM"s CS may play a physiologic role in potentiating aPC generation.	Chondroitin Sulfates	72-74	platelet factor 4	Homo sapiens	59-62
21715327-10	2011	These results suggest that this chondroitinase is useful for detailed structural and compositional analysis of chondroitin sulfate, preparation of specific chondroitin oligosaccharides, and study of baculovirus infection mechanism.	Chondroitin Sulfates	111-130	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	32-46
21653700-3	2011	Here we report that hFGF19 at picomolar levels require sulfated glycosaminoglycans (sGAGs), such as heparan sulfate, heparin, and chondroitin sulfates, for its signaling via human FGFR4 in the presence of human betaKlotho.	Chondroitin Sulfates	130-150	fibroblast growth factor 19	Homo sapiens	20-26
21651232-1	2011	Two different experimental approaches were used for obtaining a comprehensive view and understanding of the interactions between apolipoprotein B-100 (ApoB-100) of low-density lipoprotein and apolipoprotein E (ApoE) of high-density lipoprotein and chondroitin-6-sulfate (C6S) of arterial proteoglycan.	Chondroitin Sulfates	248-269	apolipoprotein B	Homo sapiens	151-159
21651232-1	2011	Two different experimental approaches were used for obtaining a comprehensive view and understanding of the interactions between apolipoprotein B-100 (ApoB-100) of low-density lipoprotein and apolipoprotein E (ApoE) of high-density lipoprotein and chondroitin-6-sulfate (C6S) of arterial proteoglycan.	Chondroitin Sulfates	248-269	apolipoprotein E	Homo sapiens	210-214
21651232-1	2011	Two different experimental approaches were used for obtaining a comprehensive view and understanding of the interactions between apolipoprotein B-100 (ApoB-100) of low-density lipoprotein and apolipoprotein E (ApoE) of high-density lipoprotein and chondroitin-6-sulfate (C6S) of arterial proteoglycan.	Chondroitin Sulfates	271-274	apolipoprotein B	Homo sapiens	129-149
21651232-1	2011	Two different experimental approaches were used for obtaining a comprehensive view and understanding of the interactions between apolipoprotein B-100 (ApoB-100) of low-density lipoprotein and apolipoprotein E (ApoE) of high-density lipoprotein and chondroitin-6-sulfate (C6S) of arterial proteoglycan.	Chondroitin Sulfates	271-274	apolipoprotein B	Homo sapiens	151-159
21651232-1	2011	Two different experimental approaches were used for obtaining a comprehensive view and understanding of the interactions between apolipoprotein B-100 (ApoB-100) of low-density lipoprotein and apolipoprotein E (ApoE) of high-density lipoprotein and chondroitin-6-sulfate (C6S) of arterial proteoglycan.	Chondroitin Sulfates	271-274	apolipoprotein E	Homo sapiens	210-214
21804080-7	2011	CD44 variants expand the CS binding repertoire of the glycoprotein; CD44v7 co-localized to the distribution of C4S in DLE lesions, a finding not observed in DM, SCLE lesions, or controls.	Chondroitin Sulfates	25-27	CD44 molecule (Indian blood group)	Homo sapiens	0-4
21804080-7	2011	CD44 variants expand the CS binding repertoire of the glycoprotein; CD44v7 co-localized to the distribution of C4S in DLE lesions, a finding not observed in DM, SCLE lesions, or controls.	Chondroitin Sulfates	25-27	complement C4A (Rodgers blood group)	Homo sapiens	111-114
21664283-4	2011	RESULTS: ARGS-SELE, ARGS-chondroitin sulfate (CS)1, GRGT-, GLGS- and AGEG-G3 fragments were the main ARGS and G3 fragments in injured and reference samples.	Chondroitin Sulfates	25-44	serpin family A member 2 (gene/pseudogene)	Homo sapiens	20-24
21652703-15	2011	The interaction of PEDF with collagen I was specifically competed with by heparin but not by chondroitin sulfate-C or hyaluronan.	Chondroitin Sulfates	93-114	serpin family F member 1	Homo sapiens	19-23
21653700-3	2011	Here we report that hFGF19 at picomolar levels require sulfated glycosaminoglycans (sGAGs), such as heparan sulfate, heparin, and chondroitin sulfates, for its signaling via human FGFR4 in the presence of human betaKlotho.	Chondroitin Sulfates	130-150	fibroblast growth factor receptor 4	Homo sapiens	180-185
21672195-9	2011	HD5 and HD6 blocked anti-HIV activities of soluble glycosaminoglycans including heparin, chondroitin sulfate, and dextran sulfate.	Chondroitin Sulfates	89-108	defensin alpha 5	Homo sapiens	0-3
21596823-1	2011	PURPOSE: Versican is a large proteoglycan with numerous chondroitin sulfate (CS) glycosaminoglycan (GAG) side chains attached.	Chondroitin Sulfates	56-75	versican	Homo sapiens	9-17
21596823-1	2011	PURPOSE: Versican is a large proteoglycan with numerous chondroitin sulfate (CS) glycosaminoglycan (GAG) side chains attached.	Chondroitin Sulfates	77-79	versican	Homo sapiens	9-17
21658254-0	2011	Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells.	Chondroitin Sulfates	0-20	chondroitin sulfate proteoglycan 4	Homo sapiens	79-84
21658254-0	2011	Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells.	Chondroitin Sulfates	0-20	carbohydrate sulfotransferase 11	Homo sapiens	89-95
21658254-0	2011	Chondroitin sulfates play a major role in breast cancer metastasis: a role for CSPG4 and CHST11 gene expression in forming surface P-selectin ligands in aggressive breast cancer cells.	Chondroitin Sulfates	0-20	selectin P	Homo sapiens	131-141
21406563-8	2011	The changes in CS/DS had implications on ligand-binding properties when tested in vitro for binding to major extracellular matrix (ECM) components such as type IV collagen, laminin and fibronectin.	Chondroitin Sulfates	15-17	fibronectin 1	Rattus norvegicus	185-196
21672195-9	2011	HD5 and HD6 blocked anti-HIV activities of soluble glycosaminoglycans including heparin, chondroitin sulfate, and dextran sulfate.	Chondroitin Sulfates	89-108	defensin alpha 6	Homo sapiens	8-11
21471214-5	2011	Hyaluronan binding was induced to a lesser extent in interleukin-4 (IL-4)-activated macrophages despite increased CD44 expression, and this was attributable to increased chondroitin sulfation on CD44, as treatment with beta-d-xyloside to prevent chondroitin sulfate addition significantly enhanced hyaluronan binding.	Chondroitin Sulfates	246-265	interleukin 4	Mus musculus	53-66
21628576-5	2011	The approach was validated through the study of known protein partners for heparan and chondroitin sulfate, including fibroblast growth factor 2 (FGF2) and its receptor FGFR1, the malarial protein VAR2CSA, and tumor necrosis factor-alpha (TNF-alpha).	Chondroitin Sulfates	87-106	fibroblast growth factor 2	Homo sapiens	146-150
21471214-5	2011	Hyaluronan binding was induced to a lesser extent in interleukin-4 (IL-4)-activated macrophages despite increased CD44 expression, and this was attributable to increased chondroitin sulfation on CD44, as treatment with beta-d-xyloside to prevent chondroitin sulfate addition significantly enhanced hyaluronan binding.	Chondroitin Sulfates	246-265	interleukin 4	Mus musculus	68-72
21398524-2	2011	The disease is caused by Plasmodium falciparum malaria parasites, which accumulate in the placenta by adhering to chondroitin sulfate A (CSA).	Chondroitin Sulfates	114-135	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	137-140
21471214-0	2011	Differential use of chondroitin sulfate to regulate hyaluronan binding by receptor CD44 in Inflammatory and Interleukin 4-activated Macrophages.	Chondroitin Sulfates	20-39	CD44 antigen	Mus musculus	83-87
21471214-0	2011	Differential use of chondroitin sulfate to regulate hyaluronan binding by receptor CD44 in Inflammatory and Interleukin 4-activated Macrophages.	Chondroitin Sulfates	20-39	interleukin 4	Mus musculus	108-121
21446997-4	2011	In the retinas from eyes injected with CS, a similar decrease in melanopsin and Thy-1 levels was observed.	Chondroitin Sulfates	39-41	opsin 4	Rattus norvegicus	65-75
21446997-4	2011	In the retinas from eyes injected with CS, a similar decrease in melanopsin and Thy-1 levels was observed.	Chondroitin Sulfates	39-41	Thy-1 cell surface antigen	Rattus norvegicus	80-85
21446997-5	2011	CS injections induced a similar decrease in the number of melanopsin-containing cells and superior collicular retinal ganglion cells.	Chondroitin Sulfates	0-2	opsin 4	Rattus norvegicus	58-68
21306301-4	2011	NRP1 is highly expressed in HAoSMCs (human aortic smooth muscle cells) and HCASMCs, and modified in VSMCs by CS (chondroitin sulfate)-rich O-linked glycosylation at Ser612.	Chondroitin Sulfates	109-111	neuropilin 1	Homo sapiens	0-4
21306301-4	2011	NRP1 is highly expressed in HAoSMCs (human aortic smooth muscle cells) and HCASMCs, and modified in VSMCs by CS (chondroitin sulfate)-rich O-linked glycosylation at Ser612.	Chondroitin Sulfates	113-132	neuropilin 1	Homo sapiens	0-4
21454754-5	2011	Heparan sulfate and analogs induced RPTPsigma ectodomain oligomerization in solution, which was inhibited by chondroitin sulfate.	Chondroitin Sulfates	109-128	protein tyrosine phosphatase receptor type S	Homo sapiens	36-45
21440637-0	2011	Electron tomography reveals multiple self-association of chondroitin sulphate/dermatan sulphate proteoglycans in Chst5-null mouse corneas.	Chondroitin Sulfates	57-77	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5	Mus musculus	113-118
21335047-0	2011	Chondroitin sulfate reduces cell death of rat hippocampal slices subjected to oxygen and glucose deprivation by inhibiting p38, NFkappaB and iNOS.	Chondroitin Sulfates	0-19	mitogen activated protein kinase 14	Rattus norvegicus	123-126
21335047-0	2011	Chondroitin sulfate reduces cell death of rat hippocampal slices subjected to oxygen and glucose deprivation by inhibiting p38, NFkappaB and iNOS.	Chondroitin Sulfates	0-19	nitric oxide synthase 2	Rattus norvegicus	141-145
21335047-5	2011	To evaluate the intracellular signaling pathways implicated in the protective effect of CS, we first analysed the participation of the mitogen-activated protein kinases (MAPKs) p38 and ERK1/2 by western blot.	Chondroitin Sulfates	88-90	mitogen activated protein kinase 14	Rattus norvegicus	177-180
21335047-5	2011	To evaluate the intracellular signaling pathways implicated in the protective effect of CS, we first analysed the participation of the mitogen-activated protein kinases (MAPKs) p38 and ERK1/2 by western blot.	Chondroitin Sulfates	88-90	mitogen activated protein kinase 3	Rattus norvegicus	185-191
21335047-6	2011	OGD/Reox induced the phosphorylation of p38 and dephosphorylation of ERK1/2; however, CS only inhibited p38 but had no effect on ERK1/2.	Chondroitin Sulfates	86-88	mitogen activated protein kinase 14	Rattus norvegicus	104-107
21335047-7	2011	Furthermore, OGD/Reox-induced translocation of p65 to the nucleus was prevented in CS treated hippocampal slices.	Chondroitin Sulfates	83-85	synaptotagmin 1	Rattus norvegicus	47-50
21335047-8	2011	Finally, CS inhibited iNOS induction caused by OGD/Reox and thereby nitric oxide (NO) production measured as a reduction in DAF-2 DA fluorescence.	Chondroitin Sulfates	9-11	nitric oxide synthase 2	Rattus norvegicus	22-26
21335047-9	2011	In conclusion, the protective effect of CS in hippocampal slices subjected to OGD/Reox can be related to a modulatory action of the local immune response by a mechanism that implies inhibition of p38, NFkappaB, iNOS and the production of NO.	Chondroitin Sulfates	40-42	mitogen activated protein kinase 14	Rattus norvegicus	196-199
21335047-9	2011	In conclusion, the protective effect of CS in hippocampal slices subjected to OGD/Reox can be related to a modulatory action of the local immune response by a mechanism that implies inhibition of p38, NFkappaB, iNOS and the production of NO.	Chondroitin Sulfates	40-42	nitric oxide synthase 2	Rattus norvegicus	211-215
21177331-6	2011	Quantitative real-time polymerase chain reaction revealed the expression of DS-epi2 to be higher than that of DS-epi1 throughout development, suggesting that DS-epi2 but not DS-epi1 is mostly expressed in the brain and plays key roles in the epimerization of CS/DS during its biosynthesis.	Chondroitin Sulfates	259-261	dermatan sulfate epimerase-like	Mus musculus	76-83
21177331-6	2011	Quantitative real-time polymerase chain reaction revealed the expression of DS-epi2 to be higher than that of DS-epi1 throughout development, suggesting that DS-epi2 but not DS-epi1 is mostly expressed in the brain and plays key roles in the epimerization of CS/DS during its biosynthesis.	Chondroitin Sulfates	259-261	dermatan sulfate epimerase-like	Mus musculus	158-165
21177331-7	2011	Moreover, an analysis of the disaccharides of CS/DS demonstrated significant amounts of IdoA-containing iD units [IdoA(2S)-GalNAc(6S)] and iB units [IdoA(2S)-GalNAc(4S)], where 2S, 4S and 6S stand for 2-O-, 4-O- and 6-O-sulfate, respectively, in every region of the brain examined.	Chondroitin Sulfates	46-48	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Mus musculus	123-132
21324437-5	2011	The time-dependent change results measured by capillary electrophoresis showed that complexation of chondroitin sulfate (CS) followed first-order reaction kinetics and that the rate of CDDP hydrolysis in the complexation for both CSA and CSC was the same.	Chondroitin Sulfates	100-119	chorionic somatomammotropin hormone 1	Homo sapiens	230-233
21324437-1	2011	Complexation of cisplatin (CDDP) and chondroitin sulfate A (CSA) or C (CSC) has been reported to reduce the nephrotoxicity of CDDP.	Chondroitin Sulfates	37-58	chorionic somatomammotropin hormone 1	Homo sapiens	60-63
21324437-5	2011	The time-dependent change results measured by capillary electrophoresis showed that complexation of chondroitin sulfate (CS) followed first-order reaction kinetics and that the rate of CDDP hydrolysis in the complexation for both CSA and CSC was the same.	Chondroitin Sulfates	121-123	chorionic somatomammotropin hormone 1	Homo sapiens	230-233
21288929-6	2011	Oversulfated chondroitin sulfate from different sources as well as heparin by-products produced activation of prekallikrein to kallikrein at variable rates as measured by the generation of kallikrein.	Chondroitin Sulfates	13-32	kallikrein related peptidase 4	Homo sapiens	113-123
21288929-6	2011	Oversulfated chondroitin sulfate from different sources as well as heparin by-products produced activation of prekallikrein to kallikrein at variable rates as measured by the generation of kallikrein.	Chondroitin Sulfates	13-32	kallikrein related peptidase 4	Homo sapiens	127-137
21138417-0	2011	Chondroitin 4-O-sulfotransferase-1 regulates the chain length of chondroitin sulfate in co-operation with chondroitin N-acetylgalactosaminyltransferase-2.	Chondroitin Sulfates	65-84	carbohydrate sulfotransferase 11	Mus musculus	0-34
21193413-0	2011	Structure-activity analysis of cathepsin K/chondroitin 4-sulfate interactions.	Chondroitin Sulfates	43-64	cathepsin K	Homo sapiens	31-42
21193413-1	2011	In the presence of oligomeric chondroitin 4-sulfate (C4-S), cathepsin K (catK) forms a specific complex that was shown to be the source of the major collagenolytic activity in bone osteoclasts.	Chondroitin Sulfates	30-51	cathepsin K	Homo sapiens	60-71
21193413-1	2011	In the presence of oligomeric chondroitin 4-sulfate (C4-S), cathepsin K (catK) forms a specific complex that was shown to be the source of the major collagenolytic activity in bone osteoclasts.	Chondroitin Sulfates	30-51	cathepsin K	Homo sapiens	73-77
21193413-1	2011	In the presence of oligomeric chondroitin 4-sulfate (C4-S), cathepsin K (catK) forms a specific complex that was shown to be the source of the major collagenolytic activity in bone osteoclasts.	Chondroitin Sulfates	53-57	cathepsin K	Homo sapiens	60-71
21193413-1	2011	In the presence of oligomeric chondroitin 4-sulfate (C4-S), cathepsin K (catK) forms a specific complex that was shown to be the source of the major collagenolytic activity in bone osteoclasts.	Chondroitin Sulfates	53-57	cathepsin K	Homo sapiens	73-77
21193413-2	2011	C4-S forms multiple contacts with amino acid residues on the backside of the catK molecule that help to facilitate complex formation.	Chondroitin Sulfates	0-4	cathepsin K	Homo sapiens	77-81
21193413-3	2011	As cathepsin L does not exhibit a significant collagenase activity in the presence or in the absence of C4-S, we substituted the C4-S interacting residues in catK with those of cathepsin L.	Chondroitin Sulfates	129-133	cathepsin K	Homo sapiens	158-162
21193413-7	2011	C4-S is not continuously ordered as it is in the wild-type catK C4-S complex.	Chondroitin Sulfates	0-4	cathepsin K	Homo sapiens	59-63
21193413-7	2011	C4-S is not continuously ordered as it is in the wild-type catK C4-S complex.	Chondroitin Sulfates	64-68	cathepsin K	Homo sapiens	59-63
21193413-10	2011	These substitutions have changed the mode of catK binding to C4-S and, as a result, have likely affected the collagenolytic potential of the variant.	Chondroitin Sulfates	61-65	cathepsin K	Homo sapiens	45-49
21284936-0	2011	Correlation of C4ST-1 and ChGn-2 expression with chondroitin sulfate chain elongation in atherosclerosis.	Chondroitin Sulfates	49-68	carbohydrate sulfotransferase 11	Mus musculus	15-21
21284936-3	2011	Recently, it has been shown that 2 Golgi enzymes, chondroitin 4-O-sulfotransferase-1 (C4ST-1) and chondroitin N-acetylgalactosaminyltransferase-2 (ChGn-2), play a critical role in CS chain elongation.	Chondroitin Sulfates	180-182	carbohydrate sulfotransferase 11	Mus musculus	50-84
21284936-3	2011	Recently, it has been shown that 2 Golgi enzymes, chondroitin 4-O-sulfotransferase-1 (C4ST-1) and chondroitin N-acetylgalactosaminyltransferase-2 (ChGn-2), play a critical role in CS chain elongation.	Chondroitin Sulfates	180-182	carbohydrate sulfotransferase 11	Mus musculus	86-92
21284936-7	2011	The binding of LDL and CS PG in this mouse model was confirmed by chondroitinase ABC (ChABC) digestion and apolipoprotein B (apo B) staining.	Chondroitin Sulfates	23-25	apolipoprotein B	Mus musculus	107-123
21284936-12	2011	Our results suggested that C4ST-1 and ChGn-2 may be involved in the elongation of CS chains in the arterial wall during the progression of atherosclerosis.	Chondroitin Sulfates	82-84	carbohydrate sulfotransferase 11	Mus musculus	27-33
20965281-5	2011	Positively charged TGF-beta1 demonstrated minimal release after loading in CS microspheres, while negatively charged TNF-alpha exhibited substantial release over the first 15 h, suggesting that TGF-beta1 electrostatically complexed with CS.	Chondroitin Sulfates	237-239	tumor necrosis factor	Homo sapiens	117-126
20965281-5	2011	Positively charged TGF-beta1 demonstrated minimal release after loading in CS microspheres, while negatively charged TNF-alpha exhibited substantial release over the first 15 h, suggesting that TGF-beta1 electrostatically complexed with CS.	Chondroitin Sulfates	237-239	transforming growth factor beta 1	Homo sapiens	194-203
21138417-2	2011	These results suggested that C4ST-1 regulates not only 4-O-sulfation of CS, but also the length and amount of CS chains; however, the mechanism remains unclear.	Chondroitin Sulfates	72-74	carbohydrate sulfotransferase 11	Mus musculus	29-35
21138417-2	2011	These results suggested that C4ST-1 regulates not only 4-O-sulfation of CS, but also the length and amount of CS chains; however, the mechanism remains unclear.	Chondroitin Sulfates	110-112	carbohydrate sulfotransferase 11	Mus musculus	29-35
21138417-3	2011	In the present study, we have demonstrated that C4ST-1 regulates the chain length and amount of CS in co-operation with ChGn-2 (chondroitin N-acetylgalactosaminyltransferase 2).	Chondroitin Sulfates	96-98	carbohydrate sulfotransferase 11	Mus musculus	48-54
21138417-6	2011	Furthermore, the non-reducing terminal 4-O-sulfation of N-acetylgalactosamine residues facilitated the elongation of CS chains by chondroitin polymerase consisting of chondroitin synthase-1 and chondroitin-polymerizing factor.	Chondroitin Sulfates	117-119	chondroitin sulfate synthase 1	Mus musculus	167-189
21138417-7	2011	Overall, these results suggest that the chain length of CS is regulated by C4ST-1 and ChGn-2 and that the enzymatic activities of these proteins play a critical role in CS elongation.	Chondroitin Sulfates	56-58	carbohydrate sulfotransferase 11	Mus musculus	75-81
21107918-2	2011	Herein, we report for the first time that extracellular matrix chondroitin sulphate proteoglycan, CSPG3 (neurocan) is upregulated after primary inflammatory injury.	Chondroitin Sulfates	63-83	neurocan	Homo sapiens	98-103
21378286-1	2011	The enzyme arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB; ASB) removes 4-sulfate groups from the sulfated glycosaminoglycans (sGAG) chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	143-164	arylsulfatase B	Homo sapiens	28-61
21378286-1	2011	The enzyme arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB; ASB) removes 4-sulfate groups from the sulfated glycosaminoglycans (sGAG) chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	143-164	arylsulfatase B	Homo sapiens	63-67
21378286-1	2011	The enzyme arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB; ASB) removes 4-sulfate groups from the sulfated glycosaminoglycans (sGAG) chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	143-164	arylsulfatase B	Homo sapiens	69-72
21378286-1	2011	The enzyme arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB; ASB) removes 4-sulfate groups from the sulfated glycosaminoglycans (sGAG) chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	166-169	arylsulfatase B	Homo sapiens	28-61
21378286-1	2011	The enzyme arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB; ASB) removes 4-sulfate groups from the sulfated glycosaminoglycans (sGAG) chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	166-169	arylsulfatase B	Homo sapiens	63-67
21378286-1	2011	The enzyme arylsulfatase B (N-acetylgalactosamine-4-sulfatase; ARSB; ASB) removes 4-sulfate groups from the sulfated glycosaminoglycans (sGAG) chondroitin-4-sulfate (C4S) and dermatan sulfate (DS).	Chondroitin Sulfates	166-169	arylsulfatase B	Homo sapiens	69-72
21148564-4	2011	Biochemically, the level of CS in Csgalnact1(-/-) cartilage was reduced to ~50% that of wild-type cartilage, whereas its chain length was similar to wild-type mice, indicating that CSGalNAcT-1 participates in the CS chain initiation as suggested in the previous study (Sakai, K., Kimata, K., Sato, T., Gotoh, M., Narimatsu, H., Shinomiya, K., and Watanabe, H. (2007) J. Biol.	Chondroitin Sulfates	28-30	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	34-44
21123170-3	2011	The specific chondroitin sulfate (CS) structure synthesized by chondroitin-4-O-sulfotransferase-1 (C4ST-1) binds to Wnt-3a with high affinity (Nadanaka, S., Ishida, M., Ikegami, M., and Kitagawa, H. (2008) J. Biol.	Chondroitin Sulfates	13-32	carbohydrate sulfotransferase 11	Mus musculus	63-97
21123170-3	2011	The specific chondroitin sulfate (CS) structure synthesized by chondroitin-4-O-sulfotransferase-1 (C4ST-1) binds to Wnt-3a with high affinity (Nadanaka, S., Ishida, M., Ikegami, M., and Kitagawa, H. (2008) J. Biol.	Chondroitin Sulfates	13-32	carbohydrate sulfotransferase 11	Mus musculus	99-105
21123170-3	2011	The specific chondroitin sulfate (CS) structure synthesized by chondroitin-4-O-sulfotransferase-1 (C4ST-1) binds to Wnt-3a with high affinity (Nadanaka, S., Ishida, M., Ikegami, M., and Kitagawa, H. (2008) J. Biol.	Chondroitin Sulfates	13-32	wingless-type MMTV integration site family, member 3A	Mus musculus	116-122
21123170-3	2011	The specific chondroitin sulfate (CS) structure synthesized by chondroitin-4-O-sulfotransferase-1 (C4ST-1) binds to Wnt-3a with high affinity (Nadanaka, S., Ishida, M., Ikegami, M., and Kitagawa, H. (2008) J. Biol.	Chondroitin Sulfates	34-36	carbohydrate sulfotransferase 11	Mus musculus	63-97
21123170-3	2011	The specific chondroitin sulfate (CS) structure synthesized by chondroitin-4-O-sulfotransferase-1 (C4ST-1) binds to Wnt-3a with high affinity (Nadanaka, S., Ishida, M., Ikegami, M., and Kitagawa, H. (2008) J. Biol.	Chondroitin Sulfates	34-36	carbohydrate sulfotransferase 11	Mus musculus	99-105
21123170-3	2011	The specific chondroitin sulfate (CS) structure synthesized by chondroitin-4-O-sulfotransferase-1 (C4ST-1) binds to Wnt-3a with high affinity (Nadanaka, S., Ishida, M., Ikegami, M., and Kitagawa, H. (2008) J. Biol.	Chondroitin Sulfates	34-36	wingless-type MMTV integration site family, member 3A	Mus musculus	116-122
21123170-7	2011	C4ST-1 expression was dramatically reduced in L cells that stably expressed Wnt-3a (L-Wnt-3a cells) and had CS with low affinity for Wnt-3a.	Chondroitin Sulfates	108-110	carbohydrate sulfotransferase 11	Mus musculus	0-6
21123170-8	2011	Forced expression of C4ST-1 in L-Wnt-3a cells inhibited diffusion of Wnt-3a due to structural alterations in CS chains mediated by C4ST-1.	Chondroitin Sulfates	109-111	carbohydrate sulfotransferase 11	Mus musculus	21-27
21123170-8	2011	Forced expression of C4ST-1 in L-Wnt-3a cells inhibited diffusion of Wnt-3a due to structural alterations in CS chains mediated by C4ST-1.	Chondroitin Sulfates	109-111	wingless-type MMTV integration site family, member 3A	Mus musculus	33-39
21123170-8	2011	Forced expression of C4ST-1 in L-Wnt-3a cells inhibited diffusion of Wnt-3a due to structural alterations in CS chains mediated by C4ST-1.	Chondroitin Sulfates	109-111	wingless-type MMTV integration site family, member 3A	Mus musculus	69-75
21268013-6	2011	Interactions between SG and C1q as well as MBL are diminished in the presence of chondroitin sulfate type E. In addition, we localized the SG-binding site to the collagen-like stalk of C1q.	Chondroitin Sulfates	81-100	serglycin	Homo sapiens	21-23
21291557-12	2011	Porcine Dsp GAG attachments were found at Ser238 and Ser250 and were comprised of chondroitin 6-sulfate and chondroitin 4-sulfate in a ratio of 7 to 3, respectively.	Chondroitin Sulfates	82-103	dentin sialophosphoprotein	Homo sapiens	8-11
21291557-12	2011	Porcine Dsp GAG attachments were found at Ser238 and Ser250 and were comprised of chondroitin 6-sulfate and chondroitin 4-sulfate in a ratio of 7 to 3, respectively.	Chondroitin Sulfates	108-129	dentin sialophosphoprotein	Homo sapiens	8-11
21268013-6	2011	Interactions between SG and C1q as well as MBL are diminished in the presence of chondroitin sulfate type E. In addition, we localized the SG-binding site to the collagen-like stalk of C1q.	Chondroitin Sulfates	81-100	complement C1q A chain	Homo sapiens	28-31
21268013-6	2011	Interactions between SG and C1q as well as MBL are diminished in the presence of chondroitin sulfate type E. In addition, we localized the SG-binding site to the collagen-like stalk of C1q.	Chondroitin Sulfates	81-100	mannose binding lectin 2	Homo sapiens	43-46
21078678-1	2011	Versican is a hyaluronan-binding, extracellular chondroitin sulfate proteoglycan produced by several tumor types, including malignant melanoma, which exists as four different splice variants.	Chondroitin Sulfates	48-67	versican	Homo sapiens	0-8
21076280-11	2011	It is unclear whether these cases are a result of exposure to a heparin-like proteoglycan such as chondroitin sulfate during surgery that binds PF4, or whether the perioperative pro-inflammatory milieu is the inciting event.	Chondroitin Sulfates	98-117	platelet factor 4	Homo sapiens	144-147
20980681-2	2011	We found that CXCL4L1 has lower affinity for heparin and chondroitin sulfate-E than platelet factor-4 (CXCL4) and showed that CXCL10 and CXCL4L1 could displace each other on microvascular endothelial cells.	Chondroitin Sulfates	57-76	platelet factor 4 variant 1	Homo sapiens	14-21
21264432-7	2011	Flavopereirine binding to chondroitin sulfate was also found, which led to different fluorescence characteristics at pH 2 and 6.	Chondroitin Sulfates	26-45	polyhomeotic homolog 2	Homo sapiens	117-127
20674212-6	2010	In particular, DeltaUA--&gt;GalNAc-4S Na(2) and DeltaUA--&gt;GalNAc-6S Na(2) were selected for quantitation of CS and DS because of their significant response and short migration time (less than 7min).The method was validated for linearity, accuracy, precision and it showed to be able in detecting selectively, DS and CS at impurity level (LOD 0.01%, w/w).	Chondroitin Sulfates	111-113	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	61-70
22056426-4	2011	The beta-catenin signal was activated by endogenous Wnt through interaction with chondroitin sulfate chains to suppress PPARG expression on the stem cell matrices and early stage matrices but not on late stage matrices.	Chondroitin Sulfates	81-100	catenin beta 1	Homo sapiens	4-16
22056426-4	2011	The beta-catenin signal was activated by endogenous Wnt through interaction with chondroitin sulfate chains to suppress PPARG expression on the stem cell matrices and early stage matrices but not on late stage matrices.	Chondroitin Sulfates	81-100	peroxisome proliferator activated receptor gamma	Homo sapiens	120-125
21062061-3	2010	Analyses in vitro and in cellulo revealed that RNase A interacts tightly with abundant cell-surface proteoglycans containing glycosaminoglycans, such as heparan sulfate and chondroitin sulfate, as well as with sialic acid-containing glycoproteins.	Chondroitin Sulfates	173-192	ribonuclease A family member 1, pancreatic	Homo sapiens	47-54
20980681-2	2011	We found that CXCL4L1 has lower affinity for heparin and chondroitin sulfate-E than platelet factor-4 (CXCL4) and showed that CXCL10 and CXCL4L1 could displace each other on microvascular endothelial cells.	Chondroitin Sulfates	57-76	platelet factor 4	Homo sapiens	14-19
20980681-2	2011	We found that CXCL4L1 has lower affinity for heparin and chondroitin sulfate-E than platelet factor-4 (CXCL4) and showed that CXCL10 and CXCL4L1 could displace each other on microvascular endothelial cells.	Chondroitin Sulfates	57-76	C-X-C motif chemokine ligand 10	Homo sapiens	126-132
21737940-0	2011	Effects of chondroitin sulfate and its oligosaccharides on toll-like receptor-mediated IL-6 secretion by macrophage-like J774.1 cells.	Chondroitin Sulfates	11-30	interleukin 6	Mus musculus	87-91
21737940-4	2011	Suppression of IL-6 secretion by smaller sized CS-A was stronger than that by intact CS-A, whereas no such size-dependent suppression was apparent for CS-C.	Chondroitin Sulfates	47-49	interleukin 6	Mus musculus	15-19
21062008-4	2010	Using a gel mobility shift assay, we found that HBD2 bound to a range of GAGs including heparin/heparan sulfate (HS), dermatan sulfate (DS), and chondroitin sulfate.	Chondroitin Sulfates	145-164	defensin beta 4A	Homo sapiens	48-52
21129727-3	2010	CHSY1 was secreted from patients" fibroblasts and was required for synthesis of chondroitin sulfate moieties.	Chondroitin Sulfates	80-99	chondroitin sulfate synthase 1	Homo sapiens	0-5
20864536-6	2010	In both wild type and serglycin-deficient mice, parasite infection resulted in highly increased extracellular levels of glycosaminoglycans, including hyaluronan and chondroitin sulfate A, suggesting a role of these substances in the general defense mechanism.	Chondroitin Sulfates	165-186	serglycin	Mus musculus	22-31
20722014-0	2010	Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate.	Chondroitin Sulfates	155-174	insulin like growth factor 1	Homo sapiens	44-72
20813348-1	2010	OBJECTIVE: Versican is a large, aggregating chondroitin sulphate proteoglycan.	Chondroitin Sulfates	44-64	versican	Mus musculus	11-19
20388016-6	2010	Our data suggest that TIMP-3 interacts with heparan sulfate and heparan sulfate proteoglycans and to a lesser extent with heparin and chondroitin sulfate.	Chondroitin Sulfates	134-153	TIMP metallopeptidase inhibitor 3	Homo sapiens	22-28
20722014-0	2010	Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate.	Chondroitin Sulfates	155-174	insulin like growth factor 1	Homo sapiens	94-122
20722014-9	2010	Binding assays showed that HB-IGF-1 bound both CS and HS, whereas IGF-1 did not bind either.	Chondroitin Sulfates	47-49	insulin like growth factor 1	Homo sapiens	30-35
20722014-12	2010	CONCLUSION: Our findings indicate that after intraarticular injection in rats, HB-IGF-1 is specifically retained in cartilage through its high abundance of CS.	Chondroitin Sulfates	156-158	insulin like growth factor 1	Homo sapiens	82-87
20688960-2	2010	Because interactions with glycosaminoglycans play a crucial role in chemokines activity, we determined the binding parameters of CXCL4 and CXCL4L1 for heparin, heparan sulfate, and chondroitin sulfate B.	Chondroitin Sulfates	181-200	platelet factor 4	Homo sapiens	129-134
20688960-2	2010	Because interactions with glycosaminoglycans play a crucial role in chemokines activity, we determined the binding parameters of CXCL4 and CXCL4L1 for heparin, heparan sulfate, and chondroitin sulfate B.	Chondroitin Sulfates	181-200	platelet factor 4 variant 1	Homo sapiens	139-146
20812917-0	2010	Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development.	Chondroitin Sulfates	0-19	chondroitin sulfate synthase 1	Mus musculus	20-55
20812917-3	2010	CS production was reduced by approximately half in CSGalNAcT1-null mice, and the amount of short-chain CS was also reduced.	Chondroitin Sulfates	0-2	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	51-61
20071458-3	2010	We found that chondroitin-4-sulfate is coexpressed with semaphorin 3A (Sema 3A) in the striatal mantle zone (SMZ), a nontarget region of neuropilin (Nrp)-1-expressing cortical interneurons flanking their migratory route in the subpallium.	Chondroitin Sulfates	14-35	semaphorin 3A	Homo sapiens	71-78
20729547-2	2010	To date six glycosyltransferases for chondroitin synthesis have been identified, and the complex of chondroitin sulfate synthase-1 (CSS1)/chondroitin synthase-1 (ChSy-1) and chondroitin sulfate synthase-2 (CSS2)/chondroitin polymerizing factor is assumed to play a major role in CS biosynthesis.	Chondroitin Sulfates	132-134	chondroitin sulfate synthase 1	Mus musculus	100-130
20729547-2	2010	To date six glycosyltransferases for chondroitin synthesis have been identified, and the complex of chondroitin sulfate synthase-1 (CSS1)/chondroitin synthase-1 (ChSy-1) and chondroitin sulfate synthase-2 (CSS2)/chondroitin polymerizing factor is assumed to play a major role in CS biosynthesis.	Chondroitin Sulfates	132-134	chondroitin sulfate synthase 1	Mus musculus	138-160
20729547-2	2010	To date six glycosyltransferases for chondroitin synthesis have been identified, and the complex of chondroitin sulfate synthase-1 (CSS1)/chondroitin synthase-1 (ChSy-1) and chondroitin sulfate synthase-2 (CSS2)/chondroitin polymerizing factor is assumed to play a major role in CS biosynthesis.	Chondroitin Sulfates	132-134	chondroitin polymerizing factor	Mus musculus	174-204
20729547-2	2010	To date six glycosyltransferases for chondroitin synthesis have been identified, and the complex of chondroitin sulfate synthase-1 (CSS1)/chondroitin synthase-1 (ChSy-1) and chondroitin sulfate synthase-2 (CSS2)/chondroitin polymerizing factor is assumed to play a major role in CS biosynthesis.	Chondroitin Sulfates	132-134	chondroitin polymerizing factor	Mus musculus	206-210
20729547-2	2010	To date six glycosyltransferases for chondroitin synthesis have been identified, and the complex of chondroitin sulfate synthase-1 (CSS1)/chondroitin synthase-1 (ChSy-1) and chondroitin sulfate synthase-2 (CSS2)/chondroitin polymerizing factor is assumed to play a major role in CS biosynthesis.	Chondroitin Sulfates	132-134	chondroitin polymerizing factor	Mus musculus	212-243
20729547-11	2010	These findings, implicating regulation of CS chain polymerization by CSS2 variants, provide insight in elucidating the mechanisms of CS biosynthesis.	Chondroitin Sulfates	42-44	chondroitin polymerizing factor	Mus musculus	69-73
20071458-3	2010	We found that chondroitin-4-sulfate is coexpressed with semaphorin 3A (Sema 3A) in the striatal mantle zone (SMZ), a nontarget region of neuropilin (Nrp)-1-expressing cortical interneurons flanking their migratory route in the subpallium.	Chondroitin Sulfates	14-35	neuropilin 1	Homo sapiens	137-147
20071458-3	2010	We found that chondroitin-4-sulfate is coexpressed with semaphorin 3A (Sema 3A) in the striatal mantle zone (SMZ), a nontarget region of neuropilin (Nrp)-1-expressing cortical interneurons flanking their migratory route in the subpallium.	Chondroitin Sulfates	14-35	neuropilin 1	Homo sapiens	149-152
20071458-5	2010	We further showed that extracellular Sema 3A binds to CS.	Chondroitin Sulfates	54-56	semaphorin 3A	Homo sapiens	37-44
20071458-6	2010	Disrupting Sema 3A-Nrp-1 signaling led migrating medial ganglionic eminence neurons to inappropriately invade the SMZ and even more so after removal of the CS side chains.	Chondroitin Sulfates	156-158	semaphorin 3A	Homo sapiens	11-24
20071458-7	2010	Moreover, we found that soluble Sema 3A enhances the CS-induced repulsion in vitro.	Chondroitin Sulfates	53-55	semaphorin 3A	Homo sapiens	32-39
20071458-8	2010	We concluded that CS acts as a repellent for cortical interneurons and that, in addition, CS restricts secreted Sema 3A within SMZ.	Chondroitin Sulfates	90-92	semaphorin 3A	Homo sapiens	112-119
20562018-2	2010	Placental sequestration has been linked to binding of chondroitin sulphate A (CSA) by the var2CSA variant of PfEMP1 expressed on the PE surface, and a substantial body of evidence shows that the immune response to var2CSA gives an effective protection against PAM.	Chondroitin Sulfates	54-76	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	78-81
20584902-1	2010	Endogenous pleiotrophin and hepatocyte growth factor (HGF) mediate the neurite outgrowth-promoting activity of chondroitin sulfate (CS)/dermatan sulfate (DS) hybrid chains isolated from embryonic pig brain.	Chondroitin Sulfates	111-130	pleiotrophin	Sus scrofa	11-23
20580388-2	2010	The general aim of this work was to examine whether common polymorphisms of genes involved in chondroitin sulphate A (CSA) synthesis influence susceptibility to and manifestation of malaria during pregnancy.	Chondroitin Sulfates	94-116	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	118-121
20600662-7	2010	CHase ABC-treatments suggested that CS is involved in the formation of phosphorylated focal adhesion kinase-positive focal contacts.	Chondroitin Sulfates	36-38	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	0-5
20600662-7	2010	CHase ABC-treatments suggested that CS is involved in the formation of phosphorylated focal adhesion kinase-positive focal contacts.	Chondroitin Sulfates	36-38	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	6-9
20584902-9	2010	Computational chemistry using molecular modeling and calculations of the electrostatic potential of the hexasaccharide and two pleiotrophin-binding octasaccharides previously isolated from CS/DS hybrid chains of embryonic pig brain identified an electronegative zone potentially involved in the molecular recognition of the oligosaccharides by pleiotrophin.	Chondroitin Sulfates	189-191	pleiotrophin	Sus scrofa	127-139
20838433-1	2010	BACKGROUND: Pregnancy-associated malaria (PAM) is a serious consequence of the adhesion to the placental receptor chondroitin sulfate A (CSA) of Plasmodium falciparum-infected erythrocytes (PE) expressing the large cysteine-rich multi-domain protein var2CSA.	Chondroitin Sulfates	114-135	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	137-140
20584902-1	2010	Endogenous pleiotrophin and hepatocyte growth factor (HGF) mediate the neurite outgrowth-promoting activity of chondroitin sulfate (CS)/dermatan sulfate (DS) hybrid chains isolated from embryonic pig brain.	Chondroitin Sulfates	111-130	hepatocyte growth factor	Sus scrofa	28-52
20584902-1	2010	Endogenous pleiotrophin and hepatocyte growth factor (HGF) mediate the neurite outgrowth-promoting activity of chondroitin sulfate (CS)/dermatan sulfate (DS) hybrid chains isolated from embryonic pig brain.	Chondroitin Sulfates	111-130	hepatocyte growth factor	Sus scrofa	54-57
20584902-1	2010	Endogenous pleiotrophin and hepatocyte growth factor (HGF) mediate the neurite outgrowth-promoting activity of chondroitin sulfate (CS)/dermatan sulfate (DS) hybrid chains isolated from embryonic pig brain.	Chondroitin Sulfates	132-134	pleiotrophin	Sus scrofa	11-23
20584902-1	2010	Endogenous pleiotrophin and hepatocyte growth factor (HGF) mediate the neurite outgrowth-promoting activity of chondroitin sulfate (CS)/dermatan sulfate (DS) hybrid chains isolated from embryonic pig brain.	Chondroitin Sulfates	132-134	hepatocyte growth factor	Sus scrofa	28-52
20584902-1	2010	Endogenous pleiotrophin and hepatocyte growth factor (HGF) mediate the neurite outgrowth-promoting activity of chondroitin sulfate (CS)/dermatan sulfate (DS) hybrid chains isolated from embryonic pig brain.	Chondroitin Sulfates	132-134	hepatocyte growth factor	Sus scrofa	54-57
20584902-3	2010	In this study, pleiotrophin- and HGF-binding domains in shark skin CS/DS were investigated.	Chondroitin Sulfates	67-69	pleiotrophin	Sus scrofa	15-27
20584902-3	2010	In this study, pleiotrophin- and HGF-binding domains in shark skin CS/DS were investigated.	Chondroitin Sulfates	67-69	hepatocyte growth factor	Sus scrofa	33-36
20584902-4	2010	A high affinity CS/DS fraction was isolated using a pleiotrophin-immobilized column.	Chondroitin Sulfates	16-18	pleiotrophin	Sus scrofa	52-64
20584902-5	2010	It showed marked neurite outgrowth-promoting activity and strong inhibitory activity against the binding of pleiotrophin to immobilized CS/DS chains from embryonic pig brain.	Chondroitin Sulfates	136-138	pleiotrophin	Sus scrofa	108-120
20584902-8	2010	It displayed a potent inhibitory effect on the binding of HGF to immobilized shark skin CS/DS chains, suggesting that the pleiotrophin- and HGF-binding domains at least partially overlap in the CS/DS chains involved in the neuritogenic activity.	Chondroitin Sulfates	88-90	hepatocyte growth factor	Sus scrofa	58-61
20584902-8	2010	It displayed a potent inhibitory effect on the binding of HGF to immobilized shark skin CS/DS chains, suggesting that the pleiotrophin- and HGF-binding domains at least partially overlap in the CS/DS chains involved in the neuritogenic activity.	Chondroitin Sulfates	194-196	hepatocyte growth factor	Sus scrofa	58-61
20584902-8	2010	It displayed a potent inhibitory effect on the binding of HGF to immobilized shark skin CS/DS chains, suggesting that the pleiotrophin- and HGF-binding domains at least partially overlap in the CS/DS chains involved in the neuritogenic activity.	Chondroitin Sulfates	194-196	pleiotrophin	Sus scrofa	122-134
20584902-8	2010	It displayed a potent inhibitory effect on the binding of HGF to immobilized shark skin CS/DS chains, suggesting that the pleiotrophin- and HGF-binding domains at least partially overlap in the CS/DS chains involved in the neuritogenic activity.	Chondroitin Sulfates	194-196	hepatocyte growth factor	Sus scrofa	140-143
20689736-0	2010	Correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in situ keratomileusis.	Chondroitin Sulfates	64-83	matrix metallopeptidase 9	Homo sapiens	24-50
20064940-6	2010	Conversely, subplate cells and chondroitin sulfate proteoglycan immunoreactivity were found at significantly deeper positions from the pial surface after injection, suggesting that Reelin partially rescues preplate splitting within 4 h. Thus, Reelin has a direct role in promoting rapid morphological differentation and orientation of L6 neurons during preplate splitting.	Chondroitin Sulfates	31-50	reelin	Homo sapiens	243-249
20716181-1	2010	Mucopolysaccharidosis (MPS) IVA is an autosomal recessive disorder caused by deficiency of the lysosomal enzyme N-acetylgalatosamine-6-sulfate sulfatase (GALNS), which leads to the accumulation of keratan sulfate and chondroitin 6-sulfate, mainly in bone.	Chondroitin Sulfates	217-238	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	154-159
20953929-10	2010	TN-C staining was shown in the cartilage surface overlying CS-positive areas.	Chondroitin Sulfates	59-61	tenascin C	Homo sapiens	0-4
20953929-13	2010	CONCLUSIONS: Our findings indicate that the distribution of TN-C is related to CS production and chondrocyte proliferation in osteoarthritic cartilage and that TN-C has effects on DNA synthesis, proteoglycan content, and aggrecan mRNA expression in vitro.	Chondroitin Sulfates	79-81	tenascin C	Homo sapiens	60-64
20690713-7	2010	The use of biologically derived counterpolyanions heparin sulfate and chondroitin sulfate in the multilayer structures enhanced FGF-2 activity.	Chondroitin Sulfates	70-89	fibroblast growth factor 2	Mus musculus	128-133
20539216-7	2010	VEGF and CD34 levels were significantly induced by chemical cauterization in the groups treated with chloramphenicol, chondroitin sulfate, and normal saline, demonstrating corneal NV.	Chondroitin Sulfates	118-137	vascular endothelial growth factor A	Rattus norvegicus	0-4
20539216-7	2010	VEGF and CD34 levels were significantly induced by chemical cauterization in the groups treated with chloramphenicol, chondroitin sulfate, and normal saline, demonstrating corneal NV.	Chondroitin Sulfates	118-137	CD34 molecule	Rattus norvegicus	9-13
20427081-0	2010	Bradykinin forming capacity of oversulfated chondroitin sulfate contaminated heparin in vitro.	Chondroitin Sulfates	44-63	kininogen 1	Homo sapiens	0-10
20689736-1	2010	AIMS: The aim of the present study was to evaluate the correlation between matrix metalloproteinase-9 (MMP-9) and chondroitin sulfate (CS) concentrations in human tear fluid following laser in situ keratomileusis (LASIK).	Chondroitin Sulfates	114-133	matrix metallopeptidase 9	Homo sapiens	75-101
20689736-1	2010	AIMS: The aim of the present study was to evaluate the correlation between matrix metalloproteinase-9 (MMP-9) and chondroitin sulfate (CS) concentrations in human tear fluid following laser in situ keratomileusis (LASIK).	Chondroitin Sulfates	114-133	matrix metallopeptidase 9	Homo sapiens	103-108
20489207-4	2010	Previous studies have shown that versican is a chondroitin sulfate proteoglycan of the ECM that is produced by synthetic SMCs and promotes SMC migration and proliferation.	Chondroitin Sulfates	47-66	versican	Homo sapiens	33-41
20463016-1	2010	The heavy chain (HC) subunits of the bikunin proteins are covalently attached to a single chondroitin sulfate (CS) chain originating from bikunin and can be transferred to different hyaluronan (HA) molecules by TSG-6/HC2.	Chondroitin Sulfates	90-109	alpha-1-microglobulin/bikunin precursor	Homo sapiens	37-44
20463016-1	2010	The heavy chain (HC) subunits of the bikunin proteins are covalently attached to a single chondroitin sulfate (CS) chain originating from bikunin and can be transferred to different hyaluronan (HA) molecules by TSG-6/HC2.	Chondroitin Sulfates	90-109	alpha-1-microglobulin/bikunin precursor	Homo sapiens	138-145
20463016-1	2010	The heavy chain (HC) subunits of the bikunin proteins are covalently attached to a single chondroitin sulfate (CS) chain originating from bikunin and can be transferred to different hyaluronan (HA) molecules by TSG-6/HC2.	Chondroitin Sulfates	90-109	TNF alpha induced protein 6	Homo sapiens	211-216
20463016-1	2010	The heavy chain (HC) subunits of the bikunin proteins are covalently attached to a single chondroitin sulfate (CS) chain originating from bikunin and can be transferred to different hyaluronan (HA) molecules by TSG-6/HC2.	Chondroitin Sulfates	111-113	alpha-1-microglobulin/bikunin precursor	Homo sapiens	37-44
20463016-1	2010	The heavy chain (HC) subunits of the bikunin proteins are covalently attached to a single chondroitin sulfate (CS) chain originating from bikunin and can be transferred to different hyaluronan (HA) molecules by TSG-6/HC2.	Chondroitin Sulfates	111-113	alpha-1-microglobulin/bikunin precursor	Homo sapiens	138-145
20463016-3	2010	Our data suggest that TSG-6/HC2 link HCs randomly on the CS chain of bikunin, in contrast to the ordered attachment observed during the biosynthesis.	Chondroitin Sulfates	57-59	TNF alpha induced protein 6	Homo sapiens	22-27
20463016-3	2010	Our data suggest that TSG-6/HC2 link HCs randomly on the CS chain of bikunin, in contrast to the ordered attachment observed during the biosynthesis.	Chondroitin Sulfates	57-59	CYCS pseudogene 38	Homo sapiens	28-31
20463016-3	2010	Our data suggest that TSG-6/HC2 link HCs randomly on the CS chain of bikunin, in contrast to the ordered attachment observed during the biosynthesis.	Chondroitin Sulfates	57-59	alpha-1-microglobulin/bikunin precursor	Homo sapiens	69-76
20439988-2	2010	N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) transfers sulfate from 3"-phosphoadenosine 5"-phosphosulfate to position 6 of N-acetylgalactosamine 4-sulfate in CS or DS to yield GalNAc(4,6-SO(4)) residues.	Chondroitin Sulfates	181-183	carbohydrate sulfotransferase 15	Mus musculus	0-52
20466649-1	2010	The hyaluronic acid receptor for endocytosis (HARE)/Stabilin-2 is the primary systemic scavenger receptor for 13 ligands including hyaluronan (HA), heparin and chondroitin sulfates.	Chondroitin Sulfates	160-180	stabilin 2	Homo sapiens	4-44
20466649-1	2010	The hyaluronic acid receptor for endocytosis (HARE)/Stabilin-2 is the primary systemic scavenger receptor for 13 ligands including hyaluronan (HA), heparin and chondroitin sulfates.	Chondroitin Sulfates	160-180	stabilin 2	Homo sapiens	46-50
20466649-1	2010	The hyaluronic acid receptor for endocytosis (HARE)/Stabilin-2 is the primary systemic scavenger receptor for 13 ligands including hyaluronan (HA), heparin and chondroitin sulfates.	Chondroitin Sulfates	160-180	stabilin 2	Homo sapiens	52-62
20404343-1	2010	Versican/PG-M is a large chondroitin sulfate proteoglycan in the extracellular matrix, which is transiently expressed in mesenchymal condensation areas during tissue morphogenesis.	Chondroitin Sulfates	25-44	versican	Mus musculus	0-8
20439988-2	2010	N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) transfers sulfate from 3"-phosphoadenosine 5"-phosphosulfate to position 6 of N-acetylgalactosamine 4-sulfate in CS or DS to yield GalNAc(4,6-SO(4)) residues.	Chondroitin Sulfates	181-183	carbohydrate sulfotransferase 15	Mus musculus	54-66
20439988-5	2010	In GalNAc4S-6ST-null mice, GalNAc(4,6-SO(4)) residues in CS and DS disappeared completely, indicating that GalNAc4S-6ST should be a sole enzyme responsible for the synthesis of GalNAc(4,6-SO(4)) residues in both CS and DS.	Chondroitin Sulfates	57-59	carbohydrate sulfotransferase 15	Mus musculus	3-15
20445443-6	2010	In-vitro studies were conducted on comparing the effect of oversulfated chondroitin-6-sulfate (S-2) with native compound (N-2) and unfractionated heparin in enhancing the activation of Glu-Plg by t-PA or u-PA using 0.05 mol/l Tris buffer (pH 7.3) containing 0.9% of NaCl.	Chondroitin Sulfates	72-93	plasminogen	Homo sapiens	189-192
20445443-6	2010	In-vitro studies were conducted on comparing the effect of oversulfated chondroitin-6-sulfate (S-2) with native compound (N-2) and unfractionated heparin in enhancing the activation of Glu-Plg by t-PA or u-PA using 0.05 mol/l Tris buffer (pH 7.3) containing 0.9% of NaCl.	Chondroitin Sulfates	72-93	plasminogen activator, tissue type	Homo sapiens	196-200
20445443-6	2010	In-vitro studies were conducted on comparing the effect of oversulfated chondroitin-6-sulfate (S-2) with native compound (N-2) and unfractionated heparin in enhancing the activation of Glu-Plg by t-PA or u-PA using 0.05 mol/l Tris buffer (pH 7.3) containing 0.9% of NaCl.	Chondroitin Sulfates	72-93	plasminogen activator, urokinase	Homo sapiens	204-208
20350813-0	2010	Disaccharide derived from chondroitin sulfate A suppressed CpG-induced IL-6 secretion in macrophage-like J774.1 cells.	Chondroitin Sulfates	26-47	interleukin 6	Mus musculus	71-75
20467806-0	2010	Preparation of chondroitin sulfate libraries containing disulfated disaccharide units and inhibition of thrombin by these chondroitin sulfates.	Chondroitin Sulfates	122-142	coagulation factor II, thrombin	Homo sapiens	104-112
20467806-3	2010	We prepared CS libraries containing E unit or D unit in various proportions by in vitro enzymatic reactions using recombinant GalNAc 4-sulfate 6-O-sulfotransferase and uronosyl 2-O-sulfotransferase, and examined their inhibitory activity toward thrombin.	Chondroitin Sulfates	12-14	coagulation factor II, thrombin	Homo sapiens	245-253
20467806-6	2010	The thrombin-catalyzed degradation of fibrinogen, a physiological substrate for thrombin, was also inhibited by the CS containing both E unit and D unit.	Chondroitin Sulfates	116-118	coagulation factor II, thrombin	Homo sapiens	4-12
20467806-6	2010	The thrombin-catalyzed degradation of fibrinogen, a physiological substrate for thrombin, was also inhibited by the CS containing both E unit and D unit.	Chondroitin Sulfates	116-118	fibrinogen beta chain	Homo sapiens	38-48
20467806-6	2010	The thrombin-catalyzed degradation of fibrinogen, a physiological substrate for thrombin, was also inhibited by the CS containing both E unit and D unit.	Chondroitin Sulfates	116-118	coagulation factor II, thrombin	Homo sapiens	80-88
20004745-10	2010	Small fraction of CS in the hydrogel composites significantly decreased IGF-1 release rate.	Chondroitin Sulfates	18-20	insulin like growth factor 1	Homo sapiens	72-77
20439988-5	2010	In GalNAc4S-6ST-null mice, GalNAc(4,6-SO(4)) residues in CS and DS disappeared completely, indicating that GalNAc4S-6ST should be a sole enzyme responsible for the synthesis of GalNAc(4,6-SO(4)) residues in both CS and DS.	Chondroitin Sulfates	57-59	carbohydrate sulfotransferase 15	Mus musculus	107-119
20439988-5	2010	In GalNAc4S-6ST-null mice, GalNAc(4,6-SO(4)) residues in CS and DS disappeared completely, indicating that GalNAc4S-6ST should be a sole enzyme responsible for the synthesis of GalNAc(4,6-SO(4)) residues in both CS and DS.	Chondroitin Sulfates	212-214	carbohydrate sulfotransferase 15	Mus musculus	3-15
20439988-5	2010	In GalNAc4S-6ST-null mice, GalNAc(4,6-SO(4)) residues in CS and DS disappeared completely, indicating that GalNAc4S-6ST should be a sole enzyme responsible for the synthesis of GalNAc(4,6-SO(4)) residues in both CS and DS.	Chondroitin Sulfates	212-214	carbohydrate sulfotransferase 15	Mus musculus	107-119
20439988-7	2010	Bone marrow-derived mast cells (BMMCs) derived from GalNAc4S-6ST-null mice contained CS without GlcA-GalNAc(4,6-SO(4)) units.	Chondroitin Sulfates	85-87	carbohydrate sulfotransferase 15	Mus musculus	52-64
20400719-5	2010	Disaccharide analysis showed that rat HMW-DSP contains glycosaminoglycan chains made of chondroitin-4-sulfate and has an average of 31-32 disaccharides/mol.	Chondroitin Sulfates	88-109	dentin sialophosphoprotein	Rattus norvegicus	42-45
20470231-2	2010	METHODS: Insulin was loaded on a patch (1.0 cm2) that had 100 dissolving microneedles with chondroitin sulfate by microfabrication technology.	Chondroitin Sulfates	91-110	insulin	Canis lupus familiaris	9-16
20164441-2	2010	The central hypothesis on follicular fluid formation suggests that production by granulosa cells of hyaluronan and the chondroitin sulfate proteoglycan versican generates an osmotic gradient.	Chondroitin Sulfates	119-138	versican	Homo sapiens	152-160
20399898-1	2010	The antiinflammatory and antiapoptotic effects of chondroitin sulfate (CS) are being used to treat osteoarthritis.	Chondroitin Sulfates	50-69	citrate synthase	Homo sapiens	71-73
20206237-5	2010	At 10 microM, CS prevented translocation of p65 to the nucleus, reduced tumour necrosis factor alpha (TNF-alpha) mRNA and mitigated cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) induction by LPS.	Chondroitin Sulfates	14-16	synaptotagmin 1	Rattus norvegicus	44-47
20206237-5	2010	At 10 microM, CS prevented translocation of p65 to the nucleus, reduced tumour necrosis factor alpha (TNF-alpha) mRNA and mitigated cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) induction by LPS.	Chondroitin Sulfates	14-16	tumor necrosis factor	Rattus norvegicus	102-111
20206237-5	2010	At 10 microM, CS prevented translocation of p65 to the nucleus, reduced tumour necrosis factor alpha (TNF-alpha) mRNA and mitigated cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) induction by LPS.	Chondroitin Sulfates	14-16	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	132-148
20206237-5	2010	At 10 microM, CS prevented translocation of p65 to the nucleus, reduced tumour necrosis factor alpha (TNF-alpha) mRNA and mitigated cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) induction by LPS.	Chondroitin Sulfates	14-16	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	150-155
20206237-5	2010	At 10 microM, CS prevented translocation of p65 to the nucleus, reduced tumour necrosis factor alpha (TNF-alpha) mRNA and mitigated cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) induction by LPS.	Chondroitin Sulfates	14-16	nitric oxide synthase 2	Rattus norvegicus	161-192
20206237-5	2010	At 10 microM, CS prevented translocation of p65 to the nucleus, reduced tumour necrosis factor alpha (TNF-alpha) mRNA and mitigated cyclooxygenase 2 (COX-2) and inducible nitric oxide synthase (iNOS) induction by LPS.	Chondroitin Sulfates	14-16	nitric oxide synthase 2	Rattus norvegicus	194-198
20176392-1	2010	Human antibodies specific for glycoprotein C (gC1) of herpes simplex virus type 1 (HSV-1) neutralized the virus infectivity and efficiently inhibited attachment of HSV-1 to human HaCaT keratinocytes and to murine mutant L cells expressing either heparan sulfate or chondroitin sulfate at the cell surface.	Chondroitin Sulfates	265-284	solute carrier family 25 member 22	Homo sapiens	46-49
19961337-1	2010	The goal of the study was to investigate bone morphogenetic protein 2 (BMP-2) and transforming growth factor beta (TGF-beta) control of the expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1), an important regulator of chondroitin sulfate synthesis in cells of the nucleus pulposus.	Chondroitin Sulfates	226-245	bone morphogenetic protein 2	Homo sapiens	41-69
19961337-1	2010	The goal of the study was to investigate bone morphogenetic protein 2 (BMP-2) and transforming growth factor beta (TGF-beta) control of the expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1), an important regulator of chondroitin sulfate synthesis in cells of the nucleus pulposus.	Chondroitin Sulfates	226-245	bone morphogenetic protein 2	Homo sapiens	71-76
19961337-1	2010	The goal of the study was to investigate bone morphogenetic protein 2 (BMP-2) and transforming growth factor beta (TGF-beta) control of the expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1), an important regulator of chondroitin sulfate synthesis in cells of the nucleus pulposus.	Chondroitin Sulfates	226-245	transforming growth factor beta 1	Homo sapiens	82-113
19961337-1	2010	The goal of the study was to investigate bone morphogenetic protein 2 (BMP-2) and transforming growth factor beta (TGF-beta) control of the expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1), an important regulator of chondroitin sulfate synthesis in cells of the nucleus pulposus.	Chondroitin Sulfates	226-245	transforming growth factor beta 1	Homo sapiens	115-123
20180882-4	2010	The molecular size of CS chains attached to brevican was smaller in hippocampal tissue from APPsw mice bearing Abeta deposits compared to non-transgenic mice, likely because of changes in the CS chains.	Chondroitin Sulfates	22-24	amyloid beta (A4) precursor protein	Mus musculus	111-116
20352164-10	2010	These highly sulfated chondroitin sulfates activate factor XII in in vitro assays, based on kallikrein release.	Chondroitin Sulfates	22-42	coagulation factor XII	Rattus norvegicus	52-62
20152898-0	2010	Arylsulfatase B regulates interaction of chondroitin-4-sulfate and kininogen in renal epithelial cells.	Chondroitin Sulfates	41-62	arylsulfatase B	Homo sapiens	0-15
20152898-1	2010	The enzyme arylsulfatase B (N-acetylgalactosamine 4-sulfatase; ASB; ARSB), which removes 4-sulfate groups from the nonreducing end of chondroitin-4-sulfate (C4S;CSA) and dermatan sulfate, has cellular effects, beyond those associated with the lysosomal storage disease mucopolysaccharidosis VI.	Chondroitin Sulfates	134-155	arylsulfatase B	Homo sapiens	11-26
20152898-1	2010	The enzyme arylsulfatase B (N-acetylgalactosamine 4-sulfatase; ASB; ARSB), which removes 4-sulfate groups from the nonreducing end of chondroitin-4-sulfate (C4S;CSA) and dermatan sulfate, has cellular effects, beyond those associated with the lysosomal storage disease mucopolysaccharidosis VI.	Chondroitin Sulfates	134-155	arylsulfatase B	Homo sapiens	28-61
20152898-1	2010	The enzyme arylsulfatase B (N-acetylgalactosamine 4-sulfatase; ASB; ARSB), which removes 4-sulfate groups from the nonreducing end of chondroitin-4-sulfate (C4S;CSA) and dermatan sulfate, has cellular effects, beyond those associated with the lysosomal storage disease mucopolysaccharidosis VI.	Chondroitin Sulfates	134-155	arylsulfatase B	Homo sapiens	63-66
20152898-1	2010	The enzyme arylsulfatase B (N-acetylgalactosamine 4-sulfatase; ASB; ARSB), which removes 4-sulfate groups from the nonreducing end of chondroitin-4-sulfate (C4S;CSA) and dermatan sulfate, has cellular effects, beyond those associated with the lysosomal storage disease mucopolysaccharidosis VI.	Chondroitin Sulfates	134-155	arylsulfatase B	Homo sapiens	68-72
20152898-1	2010	The enzyme arylsulfatase B (N-acetylgalactosamine 4-sulfatase; ASB; ARSB), which removes 4-sulfate groups from the nonreducing end of chondroitin-4-sulfate (C4S;CSA) and dermatan sulfate, has cellular effects, beyond those associated with the lysosomal storage disease mucopolysaccharidosis VI.	Chondroitin Sulfates	134-155	complement C4A (Rodgers blood group)	Homo sapiens	157-160
20336366-2	2010	The Xyl can be modified by 2-O-phosphate in both CS and HS, whereas the Gal residues can be sulfated at C-4 and/or C-6 in CS but not in HS.	Chondroitin Sulfates	122-124	complement component C6	Cricetulus griseus	115-118
20216984-1	2010	Thrombomodulin (TM), which variably contains a chondroitin sulfate (+/-CS), forms an anticoagulant complex with thrombin (IIa).	Chondroitin Sulfates	47-66	thrombomodulin	Homo sapiens	0-14
20164174-3	2010	GlcAT-I is an enzyme required for the synthesis of both chondroitin sulfate and heparan sulfate.	Chondroitin Sulfates	56-75	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)	Mus musculus	0-7
20164174-4	2010	Here we report that mice with a deletion of GlcAT-I showed remarkable reduction of the synthesis of chondroitin sulfate and heparan sulfate and embryonic lethality before the 8-cell stage because of failed cytokinesis.	Chondroitin Sulfates	100-119	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)	Mus musculus	44-51
20385007-10	2010	Over 130 ARSB mutations have been reported, causing absent or reduced arylsulfatase B (N-acetylgalactosamine 4-sulfatase) activity and interrupted dermatan sulfate and chondroitin sulfate degradation.	Chondroitin Sulfates	168-187	arylsulfatase B	Homo sapiens	9-13
20100602-1	2010	The bikunin proteins are composed of heavy chains (HCs) covalently linked to a chondroitin sulfate chain originating from Ser-10 of bikunin.	Chondroitin Sulfates	79-98	alpha-1-microglobulin/bikunin precursor	Homo sapiens	4-11
20100602-1	2010	The bikunin proteins are composed of heavy chains (HCs) covalently linked to a chondroitin sulfate chain originating from Ser-10 of bikunin.	Chondroitin Sulfates	79-98	alpha-1-microglobulin/bikunin precursor	Homo sapiens	132-139
20448346-1	2010	The high molecular weight melanoma-associated antigen (HMW-MAA) is a membrane-bound chondroitin sulphate proteoglycan that is highly expressed on the surface of melanoma cells.	Chondroitin Sulfates	84-104	chondroitin sulfate proteoglycan 4	Homo sapiens	4-53
20448346-1	2010	The high molecular weight melanoma-associated antigen (HMW-MAA) is a membrane-bound chondroitin sulphate proteoglycan that is highly expressed on the surface of melanoma cells.	Chondroitin Sulfates	84-104	chondroitin sulfate proteoglycan 4	Homo sapiens	55-62
20399900-6	2010	Chondroitin sulfate (CS) is able to diminish NF-kappaB activation and nuclear translocation in chondrocytes and synovial membrane, effects that may explain the benefits of CS in osteoarthritis.	Chondroitin Sulfates	0-19	nuclear factor kappa B subunit 1	Homo sapiens	45-54
20399900-6	2010	Chondroitin sulfate (CS) is able to diminish NF-kappaB activation and nuclear translocation in chondrocytes and synovial membrane, effects that may explain the benefits of CS in osteoarthritis.	Chondroitin Sulfates	21-23	nuclear factor kappa B subunit 1	Homo sapiens	45-54
20399900-6	2010	Chondroitin sulfate (CS) is able to diminish NF-kappaB activation and nuclear translocation in chondrocytes and synovial membrane, effects that may explain the benefits of CS in osteoarthritis.	Chondroitin Sulfates	172-174	nuclear factor kappa B subunit 1	Homo sapiens	45-54
20399900-7	2010	In addition, systemic CS reduces NF-kappaB nuclear translocation in macrophages and hepatocytes, raising the hypothesis that CS might be of benefit to treat other diseases with a strong inflammatory component.	Chondroitin Sulfates	22-24	nuclear factor kappa B subunit 1	Homo sapiens	33-42
20399900-7	2010	In addition, systemic CS reduces NF-kappaB nuclear translocation in macrophages and hepatocytes, raising the hypothesis that CS might be of benefit to treat other diseases with a strong inflammatory component.	Chondroitin Sulfates	125-127	nuclear factor kappa B subunit 1	Homo sapiens	33-42
20399901-7	2010	RESULTS: CS diminished both gene expression and protein synthesis of COX-2 and CCL2, and the histopathological score of the synovial membrane, when compared to untreated rabbits.	Chondroitin Sulfates	9-11	prostaglandin G/H synthase 2	Oryctolagus cuniculus	69-74
20399901-7	2010	RESULTS: CS diminished both gene expression and protein synthesis of COX-2 and CCL2, and the histopathological score of the synovial membrane, when compared to untreated rabbits.	Chondroitin Sulfates	9-11	C-C motif chemokine 2	Oryctolagus cuniculus	79-83
20042606-6	2010	PDGF also stimulated an increase in the chondroitin-6-sulfate to chondroitin-4-sulfate ratio of GAG chains on versican, and this effect was blocked by PKC inhibitors.	Chondroitin Sulfates	40-61	proline rich transmembrane protein 2	Homo sapiens	151-154
20042606-6	2010	PDGF also stimulated an increase in the chondroitin-6-sulfate to chondroitin-4-sulfate ratio of GAG chains on versican, and this effect was blocked by PKC inhibitors.	Chondroitin Sulfates	65-86	proline rich transmembrane protein 2	Homo sapiens	151-154
20016933-1	2010	N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) transfers sulfate to position 6 of GalNAc(4SO4) residues of chondroitin sulfate to yield chondroitin sulfate E (CS-E).	Chondroitin Sulfates	128-147	carbohydrate sulfotransferase 15	Homo sapiens	54-66
19889881-2	2010	However, human hyaluronidase-1 digests CS more slowly than hyaluronan (HA), and its preferred substrate is HA rather than CS.	Chondroitin Sulfates	39-41	hyaluronidase 1	Homo sapiens	15-30
19889881-2	2010	However, human hyaluronidase-1 digests CS more slowly than hyaluronan (HA), and its preferred substrate is HA rather than CS.	Chondroitin Sulfates	122-124	hyaluronidase 1	Homo sapiens	15-30
19889881-7	2010	In this study, human hyaluronidase-4 was demonstrated to be a CS-specific endo-beta-N-acetylgalactosaminidase.	Chondroitin Sulfates	62-64	hyaluronidase 4	Homo sapiens	21-36
20110528-5	2010	Treatment with CS at 200 and 1000 microg/ml was performed on human OA cartilage explants in the presence/absence of interleukin 1ss (IL-1ss), and the protein modulations of factors including prostaglandin E(2) (PGE(2)), IL-6, and MMP-1 measured by ELISA.	Chondroitin Sulfates	15-17	interleukin 6	Homo sapiens	220-224
20110528-5	2010	Treatment with CS at 200 and 1000 microg/ml was performed on human OA cartilage explants in the presence/absence of interleukin 1ss (IL-1ss), and the protein modulations of factors including prostaglandin E(2) (PGE(2)), IL-6, and MMP-1 measured by ELISA.	Chondroitin Sulfates	15-17	matrix metallopeptidase 1	Homo sapiens	230-235
20110528-11	2010	CONCLUSION: Our data indicate that among the 3 tested CS, CS1 increased production of some catabolic pathways and inhibited the gene expression level of collagen type II.	Chondroitin Sulfates	54-56	chorionic somatomammotropin hormone 1	Homo sapiens	58-61
20016933-1	2010	N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) transfers sulfate to position 6 of GalNAc(4SO4) residues of chondroitin sulfate to yield chondroitin sulfate E (CS-E).	Chondroitin Sulfates	157-176	carbohydrate sulfotransferase 15	Homo sapiens	54-66
20026745-3	2010	The aim of this project was to compare IL-8 and IL-18 for their relative stability, activity, and interaction with GAGs, including chondroitin sulfate, hyaluronic acid, and heparan sulfate, present in high quantities in the lungs of patients with CF.	Chondroitin Sulfates	131-150	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
20026745-3	2010	The aim of this project was to compare IL-8 and IL-18 for their relative stability, activity, and interaction with GAGs, including chondroitin sulfate, hyaluronic acid, and heparan sulfate, present in high quantities in the lungs of patients with CF.	Chondroitin Sulfates	131-150	interleukin 18	Homo sapiens	48-53
19960516-3	2010	Using a beta-catenin reporter mouse (BATGAL mouse), we show that beta-catenin signaling occurs in NG2 chondroitin sulfate proteoglycan+ (NG2) progenitors in the cortex, in subcallosal zone (SCZ) progenitors, and in subependymal cells surrounding the central canal.	Chondroitin Sulfates	102-121	catenin (cadherin associated protein), beta 1	Mus musculus	65-77
19280636-0	2010	Chondrogenic differentiation of mesenchymal stem cells embedded in a scaffold by long-term release of TGF-beta 3 complexed with chondroitin sulfate.	Chondroitin Sulfates	128-147	transforming growth factor beta 3	Homo sapiens	102-112
19280636-2	2010	To determine the optimal conditions for chondrogenesis of the embedded rMSCs, transforming growth factor-beta 3 (TGF-beta 3) was physically conjugated with chondroitin sulfate (CS) and mixed into scaffolds, which were subsequently evaluated for the differentiation of transplanted rMSCs.	Chondroitin Sulfates	156-175	transforming growth factor beta 3	Homo sapiens	78-111
19280636-2	2010	To determine the optimal conditions for chondrogenesis of the embedded rMSCs, transforming growth factor-beta 3 (TGF-beta 3) was physically conjugated with chondroitin sulfate (CS) and mixed into scaffolds, which were subsequently evaluated for the differentiation of transplanted rMSCs.	Chondroitin Sulfates	156-175	transforming growth factor beta 3	Homo sapiens	113-123
19280636-2	2010	To determine the optimal conditions for chondrogenesis of the embedded rMSCs, transforming growth factor-beta 3 (TGF-beta 3) was physically conjugated with chondroitin sulfate (CS) and mixed into scaffolds, which were subsequently evaluated for the differentiation of transplanted rMSCs.	Chondroitin Sulfates	177-179	transforming growth factor beta 3	Homo sapiens	78-111
19280636-2	2010	To determine the optimal conditions for chondrogenesis of the embedded rMSCs, transforming growth factor-beta 3 (TGF-beta 3) was physically conjugated with chondroitin sulfate (CS) and mixed into scaffolds, which were subsequently evaluated for the differentiation of transplanted rMSCs.	Chondroitin Sulfates	177-179	transforming growth factor beta 3	Homo sapiens	113-123
19280636-4	2010	The results of several different analyses of the transplanted rMSCs embedded in the scaffolds showed that rMSCs coupled with a CS-bound TGF-beta 3 encapsulated scaffold evidenced superior cartilage tissue formation as measured by an assay of specific gene and protein expression.	Chondroitin Sulfates	127-129	transforming growth factor beta 3	Homo sapiens	136-146
19280636-6	2010	These results indicate that the elastic block copolymer scaffolds combined with a CS-bound TGF-beta 3 should prove very suitable matrix for cell-based cartilage tissue engineering.	Chondroitin Sulfates	82-84	transforming growth factor beta 3	Homo sapiens	91-101
19960516-3	2010	Using a beta-catenin reporter mouse (BATGAL mouse), we show that beta-catenin signaling occurs in NG2 chondroitin sulfate proteoglycan+ (NG2) progenitors in the cortex, in subcallosal zone (SCZ) progenitors, and in subependymal cells surrounding the central canal.	Chondroitin Sulfates	102-121	chondroitin sulfate proteoglycan 4	Mus musculus	98-101
19960516-3	2010	Using a beta-catenin reporter mouse (BATGAL mouse), we show that beta-catenin signaling occurs in NG2 chondroitin sulfate proteoglycan+ (NG2) progenitors in the cortex, in subcallosal zone (SCZ) progenitors, and in subependymal cells surrounding the central canal.	Chondroitin Sulfates	102-121	chondroitin sulfate proteoglycan 4	Mus musculus	137-140
19346317-3	2010	When ASB was silenced and IL-8 production stimulated by exposure to TNF-alpha, ASB activity declined by roughly 75%, cellular C4S content increased by over 7.5 microg/mg protein, cell-bound IL-8 increased by over 530 pg/mg protein, and secreted IL-8 declined by over 520 pg/mg protein in all cell lines (P &lt; 0.001).	Chondroitin Sulfates	126-129	arylsulfatase B	Homo sapiens	5-8
19346317-0	2010	Cell-bound IL-8 increases in bronchial epithelial cells after arylsulfatase B silencing due to sequestration with chondroitin-4-sulfate.	Chondroitin Sulfates	114-135	C-X-C motif chemokine ligand 8	Homo sapiens	11-15
19346317-2	2010	To determine the role of chondroitin-4-sulfate (C4S) in mediating effects of IL-8, we silenced the enzyme N-acetylgalactosamine-4-sulfatase (arylsulfatase B [ASB]) that removes the 4-sulfate group from C4S, in the IB3-1 and C38 bronchial epithelial cell lines and in normal primary bronchial epithelial cells.	Chondroitin Sulfates	25-46	arylsulfatase B	Homo sapiens	141-156
19346317-2	2010	To determine the role of chondroitin-4-sulfate (C4S) in mediating effects of IL-8, we silenced the enzyme N-acetylgalactosamine-4-sulfatase (arylsulfatase B [ASB]) that removes the 4-sulfate group from C4S, in the IB3-1 and C38 bronchial epithelial cell lines and in normal primary bronchial epithelial cells.	Chondroitin Sulfates	48-51	C-X-C motif chemokine ligand 8	Homo sapiens	77-81
19346317-2	2010	To determine the role of chondroitin-4-sulfate (C4S) in mediating effects of IL-8, we silenced the enzyme N-acetylgalactosamine-4-sulfatase (arylsulfatase B [ASB]) that removes the 4-sulfate group from C4S, in the IB3-1 and C38 bronchial epithelial cell lines and in normal primary bronchial epithelial cells.	Chondroitin Sulfates	48-51	arylsulfatase B	Homo sapiens	141-156
20410606-1	2010	Erythropoietin (EPO) was successfully loaded on self-dissolving micropile array (SDMA) chip using chondroitin sulfate as the base polymer.	Chondroitin Sulfates	98-117	erythropoietin	Canis lupus familiaris	0-14
20410606-1	2010	Erythropoietin (EPO) was successfully loaded on self-dissolving micropile array (SDMA) chip using chondroitin sulfate as the base polymer.	Chondroitin Sulfates	98-117	erythropoietin	Canis lupus familiaris	16-19
20332636-7	2010	The production of collagen type II/X, chondroitin sulfate and aggrecan was modified, when external bFGF or VEGF had been applied.	Chondroitin Sulfates	38-57	fibroblast growth factor 2	Homo sapiens	99-103
21220932-8	2010	bFGF and VEGF significantly decreased the amount of ECMP (collagen type I, III, chondroitin sulfate) in 1g and RPM cultures, and also significantly reduced the amount of apoptotic CF as well as caspase-3.	Chondroitin Sulfates	80-99	fibroblast growth factor 2	Homo sapiens	0-4
21220932-8	2010	bFGF and VEGF significantly decreased the amount of ECMP (collagen type I, III, chondroitin sulfate) in 1g and RPM cultures, and also significantly reduced the amount of apoptotic CF as well as caspase-3.	Chondroitin Sulfates	80-99	vascular endothelial growth factor A	Homo sapiens	9-13
20431264-2	2010	Midkine binds to oversulfated structures in heparan sulfate and chondroitin sulfate.	Chondroitin Sulfates	64-83	midkine	Mus musculus	0-7
20807649-4	2010	ATCS mutations lead to either a decrease or a loss of D4ST1 activity, as revealed by absence of DS and an excess of chondroitin sulfate (CS) in patient"s fibroblasts.	Chondroitin Sulfates	2-4	carbohydrate sulfotransferase 14	Homo sapiens	54-59
20807655-4	2010	Chondroitin sulfate (CS) on cartilage surface is the long sought high-affinity receptor for GPI.	Chondroitin Sulfates	0-19	glucose-6-phosphate isomerase 1	Mus musculus	92-95
20807655-4	2010	Chondroitin sulfate (CS) on cartilage surface is the long sought high-affinity receptor for GPI.	Chondroitin Sulfates	21-23	glucose-6-phosphate isomerase 1	Mus musculus	92-95
20110869-9	2009	The inhibition of MMP3 secretion due to GS plus CS was accompanied by a decrease in TNF-alpha production.	Chondroitin Sulfates	48-50	matrix metallopeptidase 3	Homo sapiens	18-22
20110869-9	2009	The inhibition of MMP3 secretion due to GS plus CS was accompanied by a decrease in TNF-alpha production.	Chondroitin Sulfates	48-50	tumor necrosis factor	Homo sapiens	84-93
19682969-1	2009	A functional bioassay has been developed for measuring the intracellular activity of recombinant human arylsulfatase B (rhASB) on its natural glycosaminoglycan (GAG) substrates, dermatan sulfate (DS), and chondroitin sulfate (CS) when the enzyme is taken up into cultured ASB-deficient human fibroblasts (GM00519).	Chondroitin Sulfates	205-224	arylsulfatase B	Homo sapiens	103-118
19682969-1	2009	A functional bioassay has been developed for measuring the intracellular activity of recombinant human arylsulfatase B (rhASB) on its natural glycosaminoglycan (GAG) substrates, dermatan sulfate (DS), and chondroitin sulfate (CS) when the enzyme is taken up into cultured ASB-deficient human fibroblasts (GM00519).	Chondroitin Sulfates	205-224	arylsulfatase B	Homo sapiens	122-125
19682969-1	2009	A functional bioassay has been developed for measuring the intracellular activity of recombinant human arylsulfatase B (rhASB) on its natural glycosaminoglycan (GAG) substrates, dermatan sulfate (DS), and chondroitin sulfate (CS) when the enzyme is taken up into cultured ASB-deficient human fibroblasts (GM00519).	Chondroitin Sulfates	226-228	arylsulfatase B	Homo sapiens	103-118
19682969-1	2009	A functional bioassay has been developed for measuring the intracellular activity of recombinant human arylsulfatase B (rhASB) on its natural glycosaminoglycan (GAG) substrates, dermatan sulfate (DS), and chondroitin sulfate (CS) when the enzyme is taken up into cultured ASB-deficient human fibroblasts (GM00519).	Chondroitin Sulfates	226-228	arylsulfatase B	Homo sapiens	122-125
19682969-3	2009	ASB-deficient cells accumulate DS and CS, which may be partially hydrolyzed by other lysosomal hydrolases, with the reactions stopping if a GalNAc-4S residue is reached on the nonreducing end of the oligosaccharide.	Chondroitin Sulfates	38-40	arylsulfatase B	Homo sapiens	0-3
20011239-7	2009	However, we suggest that these effects were due to reduced HS, not CS, chain sulfation, because knockdown of mouse N-deacetylase/N-sulfotransferase, which catalyzes the first step of HS sulfation, in mESCs gave similar results to those observed in PAPST-knockdown mESCs, but depletion of CS chains did not.	Chondroitin Sulfates	288-290	sulfotransferase family 1D, member 1	Mus musculus	129-147
20128842-3	2009	Quantitative analysis of the optic nerves and the dorsal columns of the spinal cord revealed that the absolute numbers of mature oligodendrocytes immunolabeled for aspartoacylase and adult glial progenitor cells expressing NG2 chondroitin sulfate proteoglycan were increased in both white matter tracts of adult bax/bak-deficient mice and, to a lesser extent, bax-deficient mice, except that there was no increase in NG2-positive progenitor cells in the dorsal columns of these strains of mutant mice.	Chondroitin Sulfates	227-246	chondroitin sulfate proteoglycan 4	Mus musculus	223-226
20626852-12	2010	The chaperone GRP78 was found to be remarkably increased by GS alone and in combination with CS, a fact that unveils a putative mechanism for the reported anti-inflammatory effect of GS in OA.	Chondroitin Sulfates	93-95	heat shock protein family A (Hsp70) member 5	Homo sapiens	14-19
20190401-2	2010	Both CS-SC and CS-PC (from 1 to 100 mug/ml) effectively suppressed the interleukin (IL)-1beta (10 ng/ml)-enhanced gene expression of aggrecanase-1/a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and aggrecanase-2/ADAMTS-5 in articular chondrocytes embedded in alginate beads and synovial fibroblasts.	Chondroitin Sulfates	5-7	interleukin 1 beta	Homo sapiens	71-93
20190401-2	2010	Both CS-SC and CS-PC (from 1 to 100 mug/ml) effectively suppressed the interleukin (IL)-1beta (10 ng/ml)-enhanced gene expression of aggrecanase-1/a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and aggrecanase-2/ADAMTS-5 in articular chondrocytes embedded in alginate beads and synovial fibroblasts.	Chondroitin Sulfates	5-7	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	133-225
20190401-2	2010	Both CS-SC and CS-PC (from 1 to 100 mug/ml) effectively suppressed the interleukin (IL)-1beta (10 ng/ml)-enhanced gene expression of aggrecanase-1/a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and aggrecanase-2/ADAMTS-5 in articular chondrocytes embedded in alginate beads and synovial fibroblasts.	Chondroitin Sulfates	5-7	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	230-243
20190401-2	2010	Both CS-SC and CS-PC (from 1 to 100 mug/ml) effectively suppressed the interleukin (IL)-1beta (10 ng/ml)-enhanced gene expression of aggrecanase-1/a disintegrin and metalloproteinase with thrombospondin-like motifs (ADAMTS)-4 and aggrecanase-2/ADAMTS-5 in articular chondrocytes embedded in alginate beads and synovial fibroblasts.	Chondroitin Sulfates	5-7	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	244-252
20190401-4	2010	CS-PC, but not CS-SC effectively recovered the IL-1beta-reduced gene expression of tissue inhibitor of metalloproteinases (TIMP)-3 in chondrocytes, and enhanced the production of TIMP-1 in synovial fibroblasts.	Chondroitin Sulfates	0-2	interleukin 1 beta	Homo sapiens	47-55
20190401-4	2010	CS-PC, but not CS-SC effectively recovered the IL-1beta-reduced gene expression of tissue inhibitor of metalloproteinases (TIMP)-3 in chondrocytes, and enhanced the production of TIMP-1 in synovial fibroblasts.	Chondroitin Sulfates	0-2	TIMP metallopeptidase inhibitor 3	Homo sapiens	83-130
20190401-4	2010	CS-PC, but not CS-SC effectively recovered the IL-1beta-reduced gene expression of tissue inhibitor of metalloproteinases (TIMP)-3 in chondrocytes, and enhanced the production of TIMP-1 in synovial fibroblasts.	Chondroitin Sulfates	0-2	TIMP metallopeptidase inhibitor 1	Homo sapiens	179-185
20110869-6	2009	Furthermore we have determined the effect of GS and CS alone (100-500 micromol/L each) and in combination on MMP3 mRNA levels and MMP3 secretion in IL-1beta stimulated chondrocytes.	Chondroitin Sulfates	52-54	matrix metallopeptidase 3	Homo sapiens	109-113
20110869-6	2009	Furthermore we have determined the effect of GS and CS alone (100-500 micromol/L each) and in combination on MMP3 mRNA levels and MMP3 secretion in IL-1beta stimulated chondrocytes.	Chondroitin Sulfates	52-54	interleukin 1 beta	Homo sapiens	148-156
20110869-8	2009	Similarly a combination of CS and GS was more effective in inhibiting MMP3 gene expression and secretion than the single components.	Chondroitin Sulfates	27-29	matrix metallopeptidase 3	Homo sapiens	70-74
19346317-3	2010	When ASB was silenced and IL-8 production stimulated by exposure to TNF-alpha, ASB activity declined by roughly 75%, cellular C4S content increased by over 7.5 microg/mg protein, cell-bound IL-8 increased by over 530 pg/mg protein, and secreted IL-8 declined by over 520 pg/mg protein in all cell lines (P &lt; 0.001).	Chondroitin Sulfates	126-129	C-X-C motif chemokine ligand 8	Homo sapiens	26-30
19346317-3	2010	When ASB was silenced and IL-8 production stimulated by exposure to TNF-alpha, ASB activity declined by roughly 75%, cellular C4S content increased by over 7.5 microg/mg protein, cell-bound IL-8 increased by over 530 pg/mg protein, and secreted IL-8 declined by over 520 pg/mg protein in all cell lines (P &lt; 0.001).	Chondroitin Sulfates	126-129	tumor necrosis factor	Homo sapiens	68-77
19346317-8	2010	These findings provide evidence for the influential role of ASB and C4S in the regulation of IL-8 secretion, and suggest that changes in ASB activity and C4S content may have a significant impact on IL-8-mediated inflammatory responses.	Chondroitin Sulfates	68-71	C-X-C motif chemokine ligand 8	Homo sapiens	93-97
19346317-8	2010	These findings provide evidence for the influential role of ASB and C4S in the regulation of IL-8 secretion, and suggest that changes in ASB activity and C4S content may have a significant impact on IL-8-mediated inflammatory responses.	Chondroitin Sulfates	154-157	C-X-C motif chemokine ligand 8	Homo sapiens	199-203
19337786-6	2009	Decorin, a member of the small leucine-rich proteoglycan gene family, is composed of a core protein and a dermatan/chondroitin sulfate chain.	Chondroitin Sulfates	115-134	decorin	Mus musculus	0-7
19780903-3	2009	We found that immunization of amyloid precursor protein/presenilin 1 double-transgenic mice with MOG45D peptide, loaded on dendritic cells, led to a substantial reduction of parenchymal and perivascular amyloid beta (Abeta)-plaque burden and soluble Abeta((1-42)) peptide levels as well as reduced astrogliosis and levels of a key glial scar protein (chondroitin sulphate proteoglycan).	Chondroitin Sulfates	351-371	amyloid beta (A4) precursor protein	Mus musculus	30-55
19780903-3	2009	We found that immunization of amyloid precursor protein/presenilin 1 double-transgenic mice with MOG45D peptide, loaded on dendritic cells, led to a substantial reduction of parenchymal and perivascular amyloid beta (Abeta)-plaque burden and soluble Abeta((1-42)) peptide levels as well as reduced astrogliosis and levels of a key glial scar protein (chondroitin sulphate proteoglycan).	Chondroitin Sulfates	351-371	presenilin 1	Mus musculus	56-68
20001860-5	2009	We confirmed the underexpression of CHST2 (isoform 1 of carbohydrate sulfotransferase 2), a key protein involved in biosynthesis of chondroitin sulfate proteoglycans, and the underexpression of GPCR26 (G-protein coupled receptor 26), a protein that mediates intracellular calcium mobilization, in ONFH bones compared to controls.	Chondroitin Sulfates	132-151	carbohydrate sulfotransferase 2	Homo sapiens	36-41
20001860-5	2009	We confirmed the underexpression of CHST2 (isoform 1 of carbohydrate sulfotransferase 2), a key protein involved in biosynthesis of chondroitin sulfate proteoglycans, and the underexpression of GPCR26 (G-protein coupled receptor 26), a protein that mediates intracellular calcium mobilization, in ONFH bones compared to controls.	Chondroitin Sulfates	132-151	carbohydrate sulfotransferase 2	Homo sapiens	56-87
19951916-2	2009	We observed that PRELP inhibited in vitro and in vivo mouse osteoclastogenesis through its GAG-binding domain ((hbd)PRELP), involving (a) cell internalization through a chondroitin sulfate- and annexin II-dependent mechanism, (b) nuclear translocation, (c) interaction with p65 nuclear factor kappaB (NF-kappaB) and inhibition of its DNA binding, and (d) impairment of NF-kappaB transcriptional activity and reduction of osteoclast-specific gene expression.	Chondroitin Sulfates	169-188	proline arginine-rich end leucine-rich repeat	Mus musculus	17-22
19951916-2	2009	We observed that PRELP inhibited in vitro and in vivo mouse osteoclastogenesis through its GAG-binding domain ((hbd)PRELP), involving (a) cell internalization through a chondroitin sulfate- and annexin II-dependent mechanism, (b) nuclear translocation, (c) interaction with p65 nuclear factor kappaB (NF-kappaB) and inhibition of its DNA binding, and (d) impairment of NF-kappaB transcriptional activity and reduction of osteoclast-specific gene expression.	Chondroitin Sulfates	169-188	exocyst complex component 6	Mus musculus	112-115
19937589-1	2009	Chondroitin-4-sulfotransferase-1(C4ST-1)/carbohydrate sulfotransferase 11 (CHST11) is a Golgi-bound enzyme involved in the biosynthesis of the glycosaminoglycan chondroitin sulfate.	Chondroitin Sulfates	161-180	carbohydrate sulfotransferase 11	Mus musculus	0-40
19955379-6	2009	ROCKII(-/-) dorsal root ganglion neurons are less sensitive to inhibition by Nogo protein or by chondroitin sulfate proteoglycan in vitro.	Chondroitin Sulfates	96-115	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	0-6
19937589-1	2009	Chondroitin-4-sulfotransferase-1(C4ST-1)/carbohydrate sulfotransferase 11 (CHST11) is a Golgi-bound enzyme involved in the biosynthesis of the glycosaminoglycan chondroitin sulfate.	Chondroitin Sulfates	161-180	carbohydrate sulfotransferase 11	Mus musculus	41-73
19937589-1	2009	Chondroitin-4-sulfotransferase-1(C4ST-1)/carbohydrate sulfotransferase 11 (CHST11) is a Golgi-bound enzyme involved in the biosynthesis of the glycosaminoglycan chondroitin sulfate.	Chondroitin Sulfates	161-180	carbohydrate sulfotransferase 11	Mus musculus	75-81
19631712-10	2009	In fibrosis affected palmar fascia DS/CS proteoglycans are able to form with PDGF-BB supramolecular complexes also including other matrix components such as type III collagen and fibronectin which bind the growth factor covalently.	Chondroitin Sulfates	38-40	fibronectin 1	Homo sapiens	179-190
19516009-13	2009	Increased expression of chondroitin sulfate in retina and dermatan sulfate in choroid reflects the effects of injury and fibrosis using high doses of anti-TNF-alpha.	Chondroitin Sulfates	24-43	tumor necrosis factor	Homo sapiens	155-164
19785924-1	2009	Cells that express the NG2 chondroitin sulfate proteoglycan and platelet-derived growth factor receptor alpha (NG2 glia) are widespread in the adult human cerebral cortex and white matter and represent 10-15% of non-neuronal cells.	Chondroitin Sulfates	27-46	chondroitin sulfate proteoglycan 4	Homo sapiens	23-26
19888516-7	2009	The fucosylated chondroitin sulfate inhibits thrombin by heparin cofactor II, whereas sulfated fucan inhibits thrombin by both antithrombin and heparin cofactor II.	Chondroitin Sulfates	16-35	coagulation factor II, thrombin	Homo sapiens	45-53
19833921-4	2009	Binding involves the chondroitin sulfate chains and a specific site on the first immunoglobulin-like domain of PTPsigma.	Chondroitin Sulfates	21-40	protein tyrosine phosphatase receptor type S	Homo sapiens	111-119
19414859-0	2009	Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exosite.	Chondroitin Sulfates	12-31	coagulation factor II, thrombin	Homo sapiens	48-56
19414859-1	2009	Depolymerized holothurian glycosaminoglycan (DHG) is a fucosylated chondroitin sulfate with antithrombin-independent antithrombotic properties.	Chondroitin Sulfates	67-86	serpin family C member 1	Homo sapiens	92-104
20004762-4	2009	Mass spectrometry of glycosaminoglycans from a patient"s fibroblasts revealed absence of dermatan sulfate and excess of chondroitin sulfate, showing that 4-O sulfation by CHST14 is essential for dermatan sulfate formation in vivo.	Chondroitin Sulfates	120-139	carbohydrate sulfotransferase 14	Homo sapiens	171-177
19492981-1	2009	Chondroitin sulfate (CS), a polysaccharide moiety of proteoglycans, is one of the major components of the extracellular matrix in the central nervous system and is involved in various cellular events in the formation and maintenance of the neural network.	Chondroitin Sulfates	0-19	citrate synthase	Homo sapiens	21-23
19414243-2	2009	Chondroitin sulfate A (CsA) was employed as a polymeric additive for the formation of an ionic complex with insulin (InS).	Chondroitin Sulfates	0-21	insulin	Homo sapiens	108-115
19414243-2	2009	Chondroitin sulfate A (CsA) was employed as a polymeric additive for the formation of an ionic complex with insulin (InS).	Chondroitin Sulfates	0-21	insulin	Homo sapiens	117-120
19414243-2	2009	Chondroitin sulfate A (CsA) was employed as a polymeric additive for the formation of an ionic complex with insulin (InS).	Chondroitin Sulfates	23-26	insulin	Homo sapiens	108-115
19414243-2	2009	Chondroitin sulfate A (CsA) was employed as a polymeric additive for the formation of an ionic complex with insulin (InS).	Chondroitin Sulfates	23-26	insulin	Homo sapiens	117-120
19414243-7	2009	InS loading efficiency in the system is higher than that of the microspheres without CsA.	Chondroitin Sulfates	85-88	insulin	Homo sapiens	0-3
18989752-1	2009	Morquio A is an autosomal recessive disease caused by the deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), leading to the lysosomal accumulation of keratan-sulfate and chondroitin-6-sulfate.	Chondroitin Sulfates	184-205	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	115-120
19574454-0	2009	Reception of Slit requires only the chondroitin-sulphate-modified extracellular domain of Syndecan at the target cell surface.	Chondroitin Sulfates	36-56	syndecan 1	Homo sapiens	90-98
19389385-3	2009	This study demonstrates that the anticoagulant activity of this oversulfated chondroitin sulfate is primarily dependent on heparin cofactor II mediated inhibition of thrombin.	Chondroitin Sulfates	77-96	coagulation factor II, thrombin	Homo sapiens	166-174
19389385-5	2009	While oversulfated chondroitin sulfate binds tightly to antithrombin III, unlike heparin, OSCS does not induce antithrombin III to undergo the conformational change required for its inactivation of thrombin and factor Xa.	Chondroitin Sulfates	19-38	serpin family C member 1	Homo sapiens	56-72
19389385-5	2009	While oversulfated chondroitin sulfate binds tightly to antithrombin III, unlike heparin, OSCS does not induce antithrombin III to undergo the conformational change required for its inactivation of thrombin and factor Xa.	Chondroitin Sulfates	19-38	coagulation factor II, thrombin	Homo sapiens	60-68
19389385-6	2009	In contrast to heparin, oversulfated chondroitin sulfate tightly binds factor XIIa suggesting a biochemical mechanism for the factor XIIa-based enhancement of vasoactive bradykinin production.	Chondroitin Sulfates	37-56	kininogen 1	Homo sapiens	170-180
19574454-1	2009	Syndecan (Sdc) is a conserved transmembrane heparan sulfate proteoglycan (HSPG) bearing additional chondroitin sulfate (CS) modifications on its extracellular domain.	Chondroitin Sulfates	99-118	syndecan 1	Homo sapiens	0-8
19574454-1	2009	Syndecan (Sdc) is a conserved transmembrane heparan sulfate proteoglycan (HSPG) bearing additional chondroitin sulfate (CS) modifications on its extracellular domain.	Chondroitin Sulfates	99-118	syndecan 1	Homo sapiens	10-13
19574454-1	2009	Syndecan (Sdc) is a conserved transmembrane heparan sulfate proteoglycan (HSPG) bearing additional chondroitin sulfate (CS) modifications on its extracellular domain.	Chondroitin Sulfates	120-122	syndecan 1	Homo sapiens	0-8
19574454-1	2009	Syndecan (Sdc) is a conserved transmembrane heparan sulfate proteoglycan (HSPG) bearing additional chondroitin sulfate (CS) modifications on its extracellular domain.	Chondroitin Sulfates	120-122	syndecan 1	Homo sapiens	10-13
19574454-6	2009	However, the HSPG Dally-like protein (Dlp), which lacks CS modifications at its extracellular domain, can only partially substitute for Sdc function, and its activity is not restricted to the Slit target cells.	Chondroitin Sulfates	56-58	thioredoxin like 4B	Homo sapiens	38-41
19574454-8	2009	We propose that Dlp, which lacks CS modifications, participates in the transfer of Slit from its site of expression to the target cells, where CS-modified Sdc concentrates and presents the ligand.	Chondroitin Sulfates	33-35	thioredoxin like 4B	Homo sapiens	16-19
19574454-8	2009	We propose that Dlp, which lacks CS modifications, participates in the transfer of Slit from its site of expression to the target cells, where CS-modified Sdc concentrates and presents the ligand.	Chondroitin Sulfates	143-145	thioredoxin like 4B	Homo sapiens	16-19
19574454-8	2009	We propose that Dlp, which lacks CS modifications, participates in the transfer of Slit from its site of expression to the target cells, where CS-modified Sdc concentrates and presents the ligand.	Chondroitin Sulfates	143-145	syndecan 1	Homo sapiens	155-158
19298595-2	2009	As heparan sulphate and chondroitin sulphate are the bioactive components of syndecan-1, we analysed the signature of genes encoding 100 proteins involved in synthesis of these chains, i.e. from precursor uptake to post-translational modifications, using Affymetrix microarrays.	Chondroitin Sulfates	24-44	syndecan 1	Homo sapiens	77-87
19296475-6	2009	Confocal analysis revealed that the majority (&gt;60%) of these labeled cells also expressed NG2 chondroitin sulfate proteoglycan (NG2 glia).	Chondroitin Sulfates	97-116	chondroitin sulfate proteoglycan 4	Rattus norvegicus	93-96
19375967-4	2009	We hypothesized that this reduction in proliferation was due to C4S-mediated overactivation of fibroblast growth factor receptor 3 (FGFR3).	Chondroitin Sulfates	64-67	fibroblast growth factor receptor 3	Mus musculus	95-130
19375967-4	2009	We hypothesized that this reduction in proliferation was due to C4S-mediated overactivation of fibroblast growth factor receptor 3 (FGFR3).	Chondroitin Sulfates	64-67	fibroblast growth factor receptor 3	Mus musculus	132-137
19375967-9	2009	This suggests that accumulation of C4S in the growth plate leads to reduced expression of LIF and reduced STAT3 tyrosine phosphorylation, which results in reduced chondrocyte proliferation and ultimately shortened bones.	Chondroitin Sulfates	35-38	leukemia inhibitory factor	Mus musculus	90-93
19375967-9	2009	This suggests that accumulation of C4S in the growth plate leads to reduced expression of LIF and reduced STAT3 tyrosine phosphorylation, which results in reduced chondrocyte proliferation and ultimately shortened bones.	Chondroitin Sulfates	35-38	signal transducer and activator of transcription 3	Mus musculus	106-111
19473117-4	2009	Overexpression of FAM20B increased the amount of both chondroitin sulfate and heparan sulfate in HeLa cells, whereas the RNA interference of FAM20B resulted in a reduction of their amount in the cells.	Chondroitin Sulfates	54-73	FAM20B glycosaminoglycan xylosylkinase	Homo sapiens	18-24
19359419-1	2009	The human hyaluronic acid (HA) receptor for endocytosis (HARE/stabilin-2) is the primary clearance receptor for systemic HA, chondroitin sulfates, and heparin, but not for heparan sulfate or keratan sulfate (Harris EN, Weigel JA, Weigel PH.	Chondroitin Sulfates	125-145	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	10-39
19359419-1	2009	The human hyaluronic acid (HA) receptor for endocytosis (HARE/stabilin-2) is the primary clearance receptor for systemic HA, chondroitin sulfates, and heparin, but not for heparan sulfate or keratan sulfate (Harris EN, Weigel JA, Weigel PH.	Chondroitin Sulfates	125-145	stabilin 2	Homo sapiens	57-61
19359419-1	2009	The human hyaluronic acid (HA) receptor for endocytosis (HARE/stabilin-2) is the primary clearance receptor for systemic HA, chondroitin sulfates, and heparin, but not for heparan sulfate or keratan sulfate (Harris EN, Weigel JA, Weigel PH.	Chondroitin Sulfates	125-145	stabilin 2	Homo sapiens	62-72
19298595-3	2009	The expression of enzymes required for heparan sulphate and chondroitin sulphate biosynthesis was shown to increase in parallel with syndecan-1 expression, throughout the differentiation of memory B cells into plasmablasts and normal bone marrow plasma cells.	Chondroitin Sulfates	60-80	syndecan 1	Homo sapiens	133-143
19369399-7	2009	Direct measurements of Ihh binding to defined GAG chains demonstrated that Ihh interacts with CS, particularly chondroitin-4-sulfate.	Chondroitin Sulfates	111-132	Indian hedgehog	Mus musculus	75-78
19368346-7	2009	Combining SMME with mass spectrometry and capillary electrophoresis, we demonstrate that a crude porcine stomach mucin consists of a neutral and a sulfated mucin and is contaminated by chondroitin sulfate-containing proteoglycan and hyaluronic acid.	Chondroitin Sulfates	185-204	LOC100508689	Homo sapiens	113-118
19125692-4	2009	Recombinant C4ST-1 showed a substrate preference for chondroitin and catalysed the 4-O-sulfation of GalNAc residues, a highly frequent modification of CS in the embryos of zebrafish as well as other vertebrates.	Chondroitin Sulfates	151-153	carbohydrate (chondroitin 4) sulfotransferase 11	Danio rerio	12-18
19269971-1	2009	Versican is a large chondroitin sulfate proteoglycan of the extracellular matrix that is involved in a variety of cellular processes.	Chondroitin Sulfates	20-39	versican	Homo sapiens	0-8
19388612-1	2009	Despite the news of aid from chondroitin sulfate, recent research has questioned its efficacy in treating osteoarthritis.	Chondroitin Sulfates	29-48	activation induced cytidine deaminase	Homo sapiens	20-23
19259985-5	2009	Runx2 increases expression of the glycosyltransferase Exostosin-1 (Ext1) and heparanase, as well as alters the relative expression of N-linked sulfotransferases (Ndst1 = Ndst2 &gt; Ndst3) and enzymes mediating O-linked sulfation of heparan sulfate (Hs2st &gt; Hs6st) or chondroitin sulfate (Cs4st &gt; Cs6st).	Chondroitin Sulfates	270-289	RUNX family transcription factor 2	Homo sapiens	0-5
19259985-5	2009	Runx2 increases expression of the glycosyltransferase Exostosin-1 (Ext1) and heparanase, as well as alters the relative expression of N-linked sulfotransferases (Ndst1 = Ndst2 &gt; Ndst3) and enzymes mediating O-linked sulfation of heparan sulfate (Hs2st &gt; Hs6st) or chondroitin sulfate (Cs4st &gt; Cs6st).	Chondroitin Sulfates	270-289	N-deacetylase and N-sulfotransferase 1	Homo sapiens	162-167
19374733-2	2009	Sequestration of malaria parasite in the human placenta is mediated by interactions between chondroitin sulphate A (CSA) on the syncytiotrophoblasts and proteins expressed on the surface of infected human erythrocytes.	Chondroitin Sulfates	92-114	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	116-119
19125692-7	2009	Functional knockdown of C4ST-1 with specific antisense morpholino-oligonucleotides led to a marked decrease in the 4-O-sulfation and amount of CS in the embryos.	Chondroitin Sulfates	143-145	carbohydrate (chondroitin 4) sulfotransferase 11	Danio rerio	24-30
19125692-10	2009	These results suggest that 4-O-sulfated CS formed by C4ST-1 is essential for somitic muscle differentiation and motor axon guidance in zebrafish development.	Chondroitin Sulfates	40-42	carbohydrate (chondroitin 4) sulfotransferase 11	Danio rerio	53-59
19164294-1	2009	Versican/PG-M is a large chondroitin sulfate proteoglycan of the extracellular matrix which interacts with hyaluronan at the N-terminal G1 domain, composed of A, B, and B" subdomains.	Chondroitin Sulfates	25-44	versican	Mus musculus	0-8
19368826-0	2009	Transforming growth factor-beta1 upregulates keratan sulfate and chondroitin sulfate biosynthesis in microglias after brain injury.	Chondroitin Sulfates	65-84	transforming growth factor, beta 1	Mus musculus	0-32
19167466-4	2009	Finally, peripheral administration of ADAMTS-4 or chondroitinase ABC, two enzymes that disrupt versican integrity by the degradation of the versican core-protein or its chondroitin sulfate glycosaminoglycan side chains, respectively, also attenuated MCP-1 hyperalgesia at the site of nociceptive testing.	Chondroitin Sulfates	169-188	ADAM metallopeptidase with thrombospondin type 1 motif, 4	Rattus norvegicus	38-46
19296424-10	2009	RESULTS: A reduction of TNF-alpha-induced IL-6 release after treatment with hyaluronic acid and chondroitin sulfate was observed, indicating the anti-inflammatory action of the preparation.	Chondroitin Sulfates	96-115	tumor necrosis factor	Homo sapiens	24-33
19296424-10	2009	RESULTS: A reduction of TNF-alpha-induced IL-6 release after treatment with hyaluronic acid and chondroitin sulfate was observed, indicating the anti-inflammatory action of the preparation.	Chondroitin Sulfates	96-115	interleukin 6	Homo sapiens	42-46
19248106-0	2009	Chondroitin sulfate increases hyaluronan production by human synoviocytes through differential regulation of hyaluronan synthases: Role of p38 and Akt.	Chondroitin Sulfates	0-19	mitogen-activated protein kinase 1	Homo sapiens	139-142
19248106-0	2009	Chondroitin sulfate increases hyaluronan production by human synoviocytes through differential regulation of hyaluronan synthases: Role of p38 and Akt.	Chondroitin Sulfates	0-19	AKT serine/threonine kinase 1	Homo sapiens	147-150
19075012-0	2009	Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E. Chondroitin sulfate (CS) plays critical roles in central nervous system development and regeneration, and individual modifications of CS form a "sulfation code" that regulates growth factor signaling or neuronal growth.	Chondroitin Sulfates	57-76	contactin 1	Mus musculus	0-11
19248106-7	2009	RESULTS: CS increased HA production by FLS through up-regulation of the expression of HAS1 and HAS2.	Chondroitin Sulfates	9-11	hyaluronan synthase 1	Homo sapiens	86-90
19248106-7	2009	RESULTS: CS increased HA production by FLS through up-regulation of the expression of HAS1 and HAS2.	Chondroitin Sulfates	9-11	hyaluronan synthase 2	Homo sapiens	95-99
19248106-9	2009	Both p38 and Akt were involved in CS-induced HA accumulation.	Chondroitin Sulfates	34-36	mitogen-activated protein kinase 1	Homo sapiens	5-8
19248106-9	2009	Both p38 and Akt were involved in CS-induced HA accumulation.	Chondroitin Sulfates	34-36	AKT serine/threonine kinase 1	Homo sapiens	13-16
19248106-11	2009	CS enhanced the IL-1beta-induced level of HAS2 mRNA and reduced the level of HAS3 mRNA.	Chondroitin Sulfates	0-2	interleukin 1 beta	Homo sapiens	16-24
19248106-11	2009	CS enhanced the IL-1beta-induced level of HAS2 mRNA and reduced the level of HAS3 mRNA.	Chondroitin Sulfates	0-2	hyaluronan synthase 2	Homo sapiens	42-46
19248106-11	2009	CS enhanced the IL-1beta-induced level of HAS2 mRNA and reduced the level of HAS3 mRNA.	Chondroitin Sulfates	0-2	hyaluronan synthase 3	Homo sapiens	77-81
19248106-12	2009	IL-1beta-induced activation of p38 and JNK was slightly decreased by CS, whereas that of ERK-1/2 and Akt was enhanced.	Chondroitin Sulfates	69-71	interleukin 1 beta	Homo sapiens	0-8
19248106-12	2009	IL-1beta-induced activation of p38 and JNK was slightly decreased by CS, whereas that of ERK-1/2 and Akt was enhanced.	Chondroitin Sulfates	69-71	mitogen-activated protein kinase 1	Homo sapiens	31-34
19248106-12	2009	IL-1beta-induced activation of p38 and JNK was slightly decreased by CS, whereas that of ERK-1/2 and Akt was enhanced.	Chondroitin Sulfates	69-71	mitogen-activated protein kinase 8	Homo sapiens	39-42
19248106-14	2009	CONCLUSION: CS stimulates the synthesis of high molecular weight HA in OA FLS through up-regulation of HAS1 and HAS2.	Chondroitin Sulfates	12-14	hyaluronan synthase 1	Homo sapiens	103-107
19248106-14	2009	CONCLUSION: CS stimulates the synthesis of high molecular weight HA in OA FLS through up-regulation of HAS1 and HAS2.	Chondroitin Sulfates	12-14	hyaluronan synthase 2	Homo sapiens	112-116
19505682-6	2009	On the other hand, stimulation of cartilage-specific matrix component synthesis by IGF-1 resulted in increased chondrocyte killing and exogenous chondroitin sulfate A stimulated NK cell-mediated cytotoxicity against chondrocytes and human K562 cells.	Chondroitin Sulfates	145-166	insulin like growth factor 1	Homo sapiens	83-88
19306108-1	2009	Arylsulfatase B (ASB; N-acetylgalactosamine-4-sulfatase; 4-sulfatase; ARSB) is the enzyme that removes 4-sulfate groups from N-acetylgalactosamine 4-sulfate, which combines with glucuronate to form the disaccharide unit of chondroitin-4-sulfate (C4S).	Chondroitin Sulfates	223-244	arylsulfatase B	Homo sapiens	0-15
19306108-1	2009	Arylsulfatase B (ASB; N-acetylgalactosamine-4-sulfatase; 4-sulfatase; ARSB) is the enzyme that removes 4-sulfate groups from N-acetylgalactosamine 4-sulfate, which combines with glucuronate to form the disaccharide unit of chondroitin-4-sulfate (C4S).	Chondroitin Sulfates	223-244	arylsulfatase B	Homo sapiens	17-20
19306108-1	2009	Arylsulfatase B (ASB; N-acetylgalactosamine-4-sulfatase; 4-sulfatase; ARSB) is the enzyme that removes 4-sulfate groups from N-acetylgalactosamine 4-sulfate, which combines with glucuronate to form the disaccharide unit of chondroitin-4-sulfate (C4S).	Chondroitin Sulfates	223-244	arylsulfatase B	Homo sapiens	70-74
19306108-1	2009	Arylsulfatase B (ASB; N-acetylgalactosamine-4-sulfatase; 4-sulfatase; ARSB) is the enzyme that removes 4-sulfate groups from N-acetylgalactosamine 4-sulfate, which combines with glucuronate to form the disaccharide unit of chondroitin-4-sulfate (C4S).	Chondroitin Sulfates	246-249	arylsulfatase B	Homo sapiens	0-15
19306108-1	2009	Arylsulfatase B (ASB; N-acetylgalactosamine-4-sulfatase; 4-sulfatase; ARSB) is the enzyme that removes 4-sulfate groups from N-acetylgalactosamine 4-sulfate, which combines with glucuronate to form the disaccharide unit of chondroitin-4-sulfate (C4S).	Chondroitin Sulfates	246-249	arylsulfatase B	Homo sapiens	17-20
19306108-1	2009	Arylsulfatase B (ASB; N-acetylgalactosamine-4-sulfatase; 4-sulfatase; ARSB) is the enzyme that removes 4-sulfate groups from N-acetylgalactosamine 4-sulfate, which combines with glucuronate to form the disaccharide unit of chondroitin-4-sulfate (C4S).	Chondroitin Sulfates	246-249	arylsulfatase B	Homo sapiens	70-74
19368826-5	2009	Several key enzymes required for glycosaminoglycan biosynthesis (beta3GlcNAcT-7 and GlcNAc6ST-1 for keratan sulfate; CS synthase-1 and C6ST-1 for chondroitin sulfate) were expressed at significantly higher levels in the lesion 7 days after a knife-cut injury was made to the cerebral cortex in adult mice.	Chondroitin Sulfates	146-165	carbohydrate sulfotransferase 3	Mus musculus	135-141
19368826-8	2009	TGF-beta(1) induced the expression of the above-named enzymes in microglias, and consequently induced keratan sulfate and chondroitin sulfate biosynthesis as well as the expression of the chondroitin/keratan sulfate proteoglycan aggrecan in these cells.	Chondroitin Sulfates	122-141	transforming growth factor, beta 1	Mus musculus	0-11
19368826-11	2009	Astrocyte-conditioned medium following bFGF stimulation indeed induced keratan sulfate and chondroitin sulfate production in microglias.	Chondroitin Sulfates	91-110	fibroblast growth factor 2	Mus musculus	39-43
19368826-13	2009	Taken together, our data indicate that the biosyntheses of keratan sulfate and chondroitin sulfate are upregulated in common by TGF-beta(1) in microglias after neuronal injuries.	Chondroitin Sulfates	79-98	transforming growth factor, beta 1	Mus musculus	128-139
18816794-11	2009	Double-labeling experiments identified these cells as glial cells expressing the chondroitin sulfate proteoglycan NG2 (neuron/glial antigen 2), a glial subtype recently shown to regulate hippocampal neuron excitability.	Chondroitin Sulfates	81-100	chondroitin sulfate proteoglycan 4	Rattus norvegicus	114-117
18816794-11	2009	Double-labeling experiments identified these cells as glial cells expressing the chondroitin sulfate proteoglycan NG2 (neuron/glial antigen 2), a glial subtype recently shown to regulate hippocampal neuron excitability.	Chondroitin Sulfates	81-100	chondroitin sulfate proteoglycan 4	Rattus norvegicus	119-141
21383879-1	2009	Versican is a chondroitin sulfate proteoglycan whose isoforms are differentially expressed, but little is known of their functions in the neuronal system.	Chondroitin Sulfates	14-33	versican	Rattus norvegicus	0-8
19075012-0	2009	Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E. Chondroitin sulfate (CS) plays critical roles in central nervous system development and regeneration, and individual modifications of CS form a "sulfation code" that regulates growth factor signaling or neuronal growth.	Chondroitin Sulfates	80-99	contactin 1	Mus musculus	0-11
19075012-0	2009	Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E. Chondroitin sulfate (CS) plays critical roles in central nervous system development and regeneration, and individual modifications of CS form a "sulfation code" that regulates growth factor signaling or neuronal growth.	Chondroitin Sulfates	101-103	contactin 1	Mus musculus	0-11
19075012-0	2009	Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E. Chondroitin sulfate (CS) plays critical roles in central nervous system development and regeneration, and individual modifications of CS form a "sulfation code" that regulates growth factor signaling or neuronal growth.	Chondroitin Sulfates	214-216	contactin 1	Mus musculus	0-11
18720384-0	2008	Oversulfated chondroitin sulfate-E binds to BMP-4 and enhances osteoblast differentiation.	Chondroitin Sulfates	13-32	bone morphogenetic protein 4	Mus musculus	44-49
19729688-2	2009	In the present study we analyzed circulating levels of MMP-7 that acts on chondroitin sulphate a proteoglycan that is particularly abundant in atherosclerotic plaque and MMP-8 which acts on Type I collagen, the synthesis and degradation of which is important for stability of the plaque and correlate with the degree of severity of coronary artery disease (CAD).	Chondroitin Sulfates	74-94	matrix metallopeptidase 7	Homo sapiens	55-60
19396693-6	2009	The analysis of CS expression in the Cspg2(Delta3/Delta3) fibroblasts culture compared with wild-type fibroblasts showed that the composition of the non-sulfate chondroitin sulfate isomer on the versican core protein increased in the cell layer but decreased in the culture medium.	Chondroitin Sulfates	16-18	versican	Mus musculus	37-42
19396693-8	2009	The amount of CS in the Cspg2(Delta3/Delta3) cell layer of fibroblasts with mutant versican was dramatically decreased, contrasted to the amount in the culture medium, which increased.	Chondroitin Sulfates	14-16	versican	Mus musculus	24-29
19396693-8	2009	The amount of CS in the Cspg2(Delta3/Delta3) cell layer of fibroblasts with mutant versican was dramatically decreased, contrasted to the amount in the culture medium, which increased.	Chondroitin Sulfates	14-16	delta like canonical Notch ligand 3	Mus musculus	31-36
19068144-0	2008	Dose dependent effects of platelet derived chondroitinsulfate A on the binding of CCL5 to endothelial cells.	Chondroitin Sulfates	43-63	C-C motif chemokine ligand 5	Homo sapiens	82-86
19068144-8	2008	Using different chondroitinsulfate-subtypes we demonstrate that chondroitinsulfate A mediates the enhanced presentation of CCL5 on endothelial cells, whereas chondroitinsulfate B/C even at low concentrations block CCL5 binding.	Chondroitin Sulfates	64-82	C-C motif chemokine ligand 5	Homo sapiens	123-127
18298657-0	2008	Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-beta pathway--implication of C-Krox and Sp1.	Chondroitin Sulfates	0-20	transforming growth factor beta 1	Homo sapiens	115-123
18298657-0	2008	Chondroitin sulphate decreases collagen synthesis in normal and scleroderma fibroblasts through a Smad-independent TGF-beta pathway--implication of C-Krox and Sp1.	Chondroitin Sulfates	0-20	zinc finger and BTB domain containing 7B	Homo sapiens	148-154
18298657-3	2008	Here, we demonstrate for the first time that CS and CSf exert an inhibitory effect on type I collagen protein synthesis and decrease the corresponding mRNA steady-state levels of COL1A1 and COL1A2 in NF and SF.	Chondroitin Sulfates	45-47	collagen type I alpha 1 chain	Homo sapiens	179-185
18298657-3	2008	Here, we demonstrate for the first time that CS and CSf exert an inhibitory effect on type I collagen protein synthesis and decrease the corresponding mRNA steady-state levels of COL1A1 and COL1A2 in NF and SF.	Chondroitin Sulfates	45-47	collagen type I alpha 2 chain	Homo sapiens	190-196
18298657-5	2008	In addition, CS and CSf induced a down-regulation of TbetaRI expression.	Chondroitin Sulfates	13-15	transforming growth factor beta receptor 1	Homo sapiens	53-60
18298657-6	2008	As a conclusion, our findings highlight a possible new role for CS and CSf as anti-fibrotic molecules and could help in elucidating the mechanisms of action by which CS and CSf exert their inhibitory effect on type I collagen synthesis.	Chondroitin Sulfates	64-66	colony stimulating factor 2	Homo sapiens	173-176
18298657-6	2008	As a conclusion, our findings highlight a possible new role for CS and CSf as anti-fibrotic molecules and could help in elucidating the mechanisms of action by which CS and CSf exert their inhibitory effect on type I collagen synthesis.	Chondroitin Sulfates	71-73	colony stimulating factor 2	Homo sapiens	173-176
18981124-3	2008	Jurkat T cells transfected with CD44 mutated at S180, which prevented the addition of chondroitin sulfate, displayed constitutively high levels of hyaluronan binding.	Chondroitin Sulfates	86-105	CD44 molecule (Indian blood group)	Homo sapiens	32-36
18720384-11	2008	These results in the present study indicate that oversulfated CS, which possesses 4,6-disulfates in N-acetyl-galactosamine, binds to BMP-4 and promotes osteoblast differentiation and subsequent mineralization.	Chondroitin Sulfates	62-64	bone morphogenetic protein 4	Mus musculus	133-138
18524635-4	2008	RESULTS: Bikunin.chondroitin sulfate (CS) and IalphaI were abundant in OA cartilages, but virtually undetectable in normal.	Chondroitin Sulfates	17-36	alpha-1-microglobulin/bikunin precursor	Homo sapiens	9-16
18524635-4	2008	RESULTS: Bikunin.chondroitin sulfate (CS) and IalphaI were abundant in OA cartilages, but virtually undetectable in normal.	Chondroitin Sulfates	38-40	alpha-1-microglobulin/bikunin precursor	Homo sapiens	9-16
18524635-11	2008	The presence of bikunin.CS and IalphaI in OA cartilage, but not in normal, appears to be due to diffusional uptake and retention through fibrillated (but not deeply fissured) cartilage surfaces.	Chondroitin Sulfates	24-26	alpha-1-microglobulin/bikunin precursor	Homo sapiens	16-23
18433381-0	2008	SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription.	Chondroitin Sulfates	28-47	SRY-box transcription factor 9	Homo sapiens	0-4
19688944-4	2009	Versican is a chondroitin sulfate proteoglycan that constitutes the main component of the ECM.	Chondroitin Sulfates	14-33	versican	Homo sapiens	0-8
18692071-0	2008	The crystal and molecular structures of a cathepsin K:chondroitin sulfate complex.	Chondroitin Sulfates	54-73	cathepsin K	Homo sapiens	42-53
18692071-2	2008	We showed earlier that the unique triple-helical collagen-degrading activity of cathepsin K depends on the formation of complexes with bone-or cartilage-resident glycosaminoglycans, such as chondroitin 4-sulfate (C4-S).	Chondroitin Sulfates	190-211	cathepsin K	Homo sapiens	80-91
18692071-2	2008	We showed earlier that the unique triple-helical collagen-degrading activity of cathepsin K depends on the formation of complexes with bone-or cartilage-resident glycosaminoglycans, such as chondroitin 4-sulfate (C4-S).	Chondroitin Sulfates	213-217	cathepsin K	Homo sapiens	80-91
18800802-0	2008	Chondroitin sulfate extracted from ascidian tunic inhibits phorbol ester-induced expression of Inflammatory factors VCAM-1 and COX-2 by blocking NF-kappaB activation in mouse skin.	Chondroitin Sulfates	0-19	vascular cell adhesion molecule 1	Mus musculus	116-122
18800802-0	2008	Chondroitin sulfate extracted from ascidian tunic inhibits phorbol ester-induced expression of Inflammatory factors VCAM-1 and COX-2 by blocking NF-kappaB activation in mouse skin.	Chondroitin Sulfates	0-19	cytochrome c oxidase II, mitochondrial	Mus musculus	127-132
18800802-3	2008	TPA was topically applied to the shaven backs of ICR mice with or without CS (1 or 2 mg) for 4 h. The results demonstrated that CS suppressed TPA-induced edema and reduced the expression of cyclooxygenase-2, vascular cell adhesion molecule-1, and Akt signaling in mouse skin.	Chondroitin Sulfates	128-130	prostaglandin-endoperoxide synthase 2	Mus musculus	190-206
18800802-3	2008	TPA was topically applied to the shaven backs of ICR mice with or without CS (1 or 2 mg) for 4 h. The results demonstrated that CS suppressed TPA-induced edema and reduced the expression of cyclooxygenase-2, vascular cell adhesion molecule-1, and Akt signaling in mouse skin.	Chondroitin Sulfates	128-130	vascular cell adhesion molecule 1	Mus musculus	208-241
18800802-3	2008	TPA was topically applied to the shaven backs of ICR mice with or without CS (1 or 2 mg) for 4 h. The results demonstrated that CS suppressed TPA-induced edema and reduced the expression of cyclooxygenase-2, vascular cell adhesion molecule-1, and Akt signaling in mouse skin.	Chondroitin Sulfates	128-130	thymoma viral proto-oncogene 1	Mus musculus	247-250
18667431-0	2008	Chondroitin 4-O-sulfotransferase-1 modulates Wnt-3a signaling through control of E disaccharide expression of chondroitin sulfate.	Chondroitin Sulfates	110-129	carbohydrate sulfotransferase 11	Mus musculus	0-34
18667431-0	2008	Chondroitin 4-O-sulfotransferase-1 modulates Wnt-3a signaling through control of E disaccharide expression of chondroitin sulfate.	Chondroitin Sulfates	110-129	wingless-type MMTV integration site family, member 3A	Mus musculus	45-51
18667431-3	2008	Here we show the importance of chondroitin sulfate (CS) proteoglycans in the efficient signaling of Wnt-3a and the structural features of CS required for the regulation of Wnt-3a signaling.	Chondroitin Sulfates	31-50	wingless-type MMTV integration site family, member 3A	Mus musculus	100-106
18667431-3	2008	Here we show the importance of chondroitin sulfate (CS) proteoglycans in the efficient signaling of Wnt-3a and the structural features of CS required for the regulation of Wnt-3a signaling.	Chondroitin Sulfates	31-50	wingless-type MMTV integration site family, member 3A	Mus musculus	172-178
18667431-3	2008	Here we show the importance of chondroitin sulfate (CS) proteoglycans in the efficient signaling of Wnt-3a and the structural features of CS required for the regulation of Wnt-3a signaling.	Chondroitin Sulfates	52-54	wingless-type MMTV integration site family, member 3A	Mus musculus	100-106
18667431-3	2008	Here we show the importance of chondroitin sulfate (CS) proteoglycans in the efficient signaling of Wnt-3a and the structural features of CS required for the regulation of Wnt-3a signaling.	Chondroitin Sulfates	138-140	wingless-type MMTV integration site family, member 3A	Mus musculus	172-178
18667431-6	2008	In addition, the expression level of introduced C4ST-1 correlated with the recovery of Wnt-3a signaling accompanied by the increased expression of the E disaccharide unit of CS.	Chondroitin Sulfates	174-176	carbohydrate sulfotransferase 11	Mus musculus	48-54
18667431-6	2008	In addition, the expression level of introduced C4ST-1 correlated with the recovery of Wnt-3a signaling accompanied by the increased expression of the E disaccharide unit of CS.	Chondroitin Sulfates	174-176	wingless-type MMTV integration site family, member 3A	Mus musculus	87-93
18667431-7	2008	Interestingly, molecular interaction analyses using Biacore revealed that squid CS-E (rich in the E disaccharide unit) bound strongly to Wnt-3a (K(d)=13.2 nm) to the same extent as heparin from bovine lung (K(d)=8.43 nm).	Chondroitin Sulfates	80-82	Wnt family member 3A	Bos taurus	137-143
18667431-9	2008	Moreover, exogenously added CS-E potently inhibited the accumulation of beta-catenin induced by Wnt-3a.	Chondroitin Sulfates	28-30	catenin (cadherin associated protein), beta 1	Mus musculus	72-84
18667431-9	2008	Moreover, exogenously added CS-E potently inhibited the accumulation of beta-catenin induced by Wnt-3a.	Chondroitin Sulfates	28-30	wingless-type MMTV integration site family, member 3A	Mus musculus	96-102
18667431-10	2008	These results suggest that CS-E-like structures synthesized by C4ST-1 participate in Wnt-3a signaling and modulate the physiological events caused by Wnt-3a signals.	Chondroitin Sulfates	27-29	carbohydrate sulfotransferase 11	Mus musculus	63-69
18667431-10	2008	These results suggest that CS-E-like structures synthesized by C4ST-1 participate in Wnt-3a signaling and modulate the physiological events caused by Wnt-3a signals.	Chondroitin Sulfates	27-29	wingless-type MMTV integration site family, member 3A	Mus musculus	85-91
18667431-10	2008	These results suggest that CS-E-like structures synthesized by C4ST-1 participate in Wnt-3a signaling and modulate the physiological events caused by Wnt-3a signals.	Chondroitin Sulfates	27-29	wingless-type MMTV integration site family, member 3A	Mus musculus	150-156
18765417-4	2008	A continuous 2-week delivery of DNAXTas near the rostral border of a peripheral nerve graft bridging the transected dorsal columns in the thoracic spinal cord resulted in an 81% decrease in XT-1 mRNA, an average of 1.4-fold reduction in GAG-side chains of chondroitin sulphate or heparan sulphate-PGs and 2.2-fold reduction in neurocan and brevican core proteins in scar tissue.	Chondroitin Sulfates	256-276	xylosyltransferase 1	Rattus norvegicus	190-194
18704117-0	2008	Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway.	Chondroitin Sulfates	0-20	neuropilin 1	Homo sapiens	30-42
18704117-0	2008	Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway.	Chondroitin Sulfates	0-20	BCAR1 scaffold protein, Cas family member	Homo sapiens	156-163
18704117-2	2008	Here, we describe the expression of a new chondroitin sulphate-modified NRP1 (NRP1-CS) in human tumour cell lines.	Chondroitin Sulfates	42-62	neuropilin 1	Homo sapiens	72-76
18704117-2	2008	Here, we describe the expression of a new chondroitin sulphate-modified NRP1 (NRP1-CS) in human tumour cell lines.	Chondroitin Sulfates	42-62	neuropilin 1	Homo sapiens	78-85
18768934-3	2008	Chondroitin-4-sulfate (CS-A), but not chondroitin-6-sulfate (CS-C), exhibits a strong negative guidance cue to mouse cerebellar granule neurons.	Chondroitin Sulfates	23-27	carbohydrate sulfotransferase 11	Mus musculus	0-13
18433381-1	2008	The transcription factor SOX9 (Sry-type high-mobility-group box 9) is expressed in all chondrocytes and is essential for the expression of aggrecan, which during biosynthesis is substituted with more than 10 times its weight of CS (chondroitin sulfate) and is secreted by chondrocytes to form the characteristic GAG (glycosaminoglycan)-rich ECM (extracellular matrix) of cartilage.	Chondroitin Sulfates	228-230	SRY-box transcription factor 9	Homo sapiens	25-29
18433381-1	2008	The transcription factor SOX9 (Sry-type high-mobility-group box 9) is expressed in all chondrocytes and is essential for the expression of aggrecan, which during biosynthesis is substituted with more than 10 times its weight of CS (chondroitin sulfate) and is secreted by chondrocytes to form the characteristic GAG (glycosaminoglycan)-rich ECM (extracellular matrix) of cartilage.	Chondroitin Sulfates	228-230	SRY-box transcription factor 9	Homo sapiens	31-65
18433381-1	2008	The transcription factor SOX9 (Sry-type high-mobility-group box 9) is expressed in all chondrocytes and is essential for the expression of aggrecan, which during biosynthesis is substituted with more than 10 times its weight of CS (chondroitin sulfate) and is secreted by chondrocytes to form the characteristic GAG (glycosaminoglycan)-rich ECM (extracellular matrix) of cartilage.	Chondroitin Sulfates	232-251	SRY-box transcription factor 9	Homo sapiens	25-29
18433381-1	2008	The transcription factor SOX9 (Sry-type high-mobility-group box 9) is expressed in all chondrocytes and is essential for the expression of aggrecan, which during biosynthesis is substituted with more than 10 times its weight of CS (chondroitin sulfate) and is secreted by chondrocytes to form the characteristic GAG (glycosaminoglycan)-rich ECM (extracellular matrix) of cartilage.	Chondroitin Sulfates	232-251	SRY-box transcription factor 9	Homo sapiens	31-65
18433381-2	2008	SOX9 expression rapidly falls during monolayer culture of isolated chondrocytes and this turns off aggrecan and associated CS synthesis.	Chondroitin Sulfates	123-125	SRY-box transcription factor 9	Homo sapiens	0-4
18433381-9	2008	Therefore SOX9 transduction in chondrocytes increased their CS synthetic capacity, but this was not accompanied by changes in the transcription of the CS biosynthetic enzymes and must occur by indirect regulation of enzyme activity through control of enzyme protein translation or enzyme organization.	Chondroitin Sulfates	60-62	SRY-box transcription factor 9	Homo sapiens	10-14
18560887-5	2008	The majority of the new cells were immunoreactive for NG2 chondroitin sulfate, a marker for specific progenitor cells, but not for NeuN, a neuronal marker.	Chondroitin Sulfates	58-77	chondroitin sulfate proteoglycan 4	Homo sapiens	54-57
18456345-5	2008	Inhibition of cell-to-cell spread by bovine Lfcin involved cell surface chondroitin sulfate.	Chondroitin Sulfates	72-91	lactotransferrin	Homo sapiens	44-49
18768520-1	2008	The glycosaminoglycan chondroitin sulfate is significantly increased in the peritumoral stroma of prostate tumors compared with normal stroma and is an independent predictor of prostate-specific antigen (PSA) relapse following radical prostatectomy.	Chondroitin Sulfates	22-41	kallikrein related peptidase 3	Homo sapiens	177-208
18480156-5	2008	The amounts of B and D units, which are generated by UST activity, in the cerebellar CS chains also increased during development.	Chondroitin Sulfates	85-87	uronyl-2-sulfotransferase	Mus musculus	53-56
18692071-3	2008	Here, we describe the crystal structure of a 1:n complex of cathepsin K:C4-S inhibited by E64 at a resolution of 1.8 A.	Chondroitin Sulfates	72-76	cathepsin K	Homo sapiens	60-71
18692071-8	2008	Biochemical analyses of cathepsin K and C4-S mixtures support the presence of a 1:n complex in solution; a dissociation constant, K(d), of about 10 nM was determined for the interaction between cathepsin K and C4-S.	Chondroitin Sulfates	40-44	cathepsin K	Homo sapiens	194-205
18692071-8	2008	Biochemical analyses of cathepsin K and C4-S mixtures support the presence of a 1:n complex in solution; a dissociation constant, K(d), of about 10 nM was determined for the interaction between cathepsin K and C4-S.	Chondroitin Sulfates	210-214	cathepsin K	Homo sapiens	24-35
18692071-8	2008	Biochemical analyses of cathepsin K and C4-S mixtures support the presence of a 1:n complex in solution; a dissociation constant, K(d), of about 10 nM was determined for the interaction between cathepsin K and C4-S.	Chondroitin Sulfates	210-214	cathepsin K	Homo sapiens	194-205
18766257-8	2008	Clearly, fucosylated chondroitin sulfate inhibits the intrinsic tenase and prothrombinase complexes, which are critical for thrombin generation.	Chondroitin Sulfates	21-40	coagulation factor II, thrombin	Homo sapiens	78-86
18766257-9	2008	It is possible that the invertebrate chondroitin sulfate inhibits interactions between cofactor Va and factor Xa.	Chondroitin Sulfates	37-56	coagulation factor X	Homo sapiens	103-112
18539895-9	2008	These data, together, show that leukocyte surface chondroitin sulfates promote neutrophil activation by enhancing immune-complex binding to CD32a.	Chondroitin Sulfates	50-70	Fc gamma receptor IIa	Homo sapiens	140-145
18499864-0	2008	The ligand-binding profile of HARE: hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate, and CS-E.	Chondroitin Sulfates	51-71	stabilin 2	Homo sapiens	30-34
18499864-0	2008	The ligand-binding profile of HARE: hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate, and CS-E.	Chondroitin Sulfates	205-207	stabilin 2	Homo sapiens	30-34
18499864-1	2008	The hyaluronic acid receptor for endocytosis (HARE)/ Stabilin-2 is the primary systemic scavenger receptor for hyaluronan (HA), the chondroitin sulfates (CS), dermatan sulfate (DS), and nonglycosaminoglycan (GAG) ligands such as acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides, and advanced glycation end products.	Chondroitin Sulfates	132-152	stabilin 2	Homo sapiens	46-50
18499864-1	2008	The hyaluronic acid receptor for endocytosis (HARE)/ Stabilin-2 is the primary systemic scavenger receptor for hyaluronan (HA), the chondroitin sulfates (CS), dermatan sulfate (DS), and nonglycosaminoglycan (GAG) ligands such as acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides, and advanced glycation end products.	Chondroitin Sulfates	132-152	stabilin 2	Homo sapiens	53-63
18499864-1	2008	The hyaluronic acid receptor for endocytosis (HARE)/ Stabilin-2 is the primary systemic scavenger receptor for hyaluronan (HA), the chondroitin sulfates (CS), dermatan sulfate (DS), and nonglycosaminoglycan (GAG) ligands such as acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides, and advanced glycation end products.	Chondroitin Sulfates	154-156	stabilin 2	Homo sapiens	46-50
18499864-1	2008	The hyaluronic acid receptor for endocytosis (HARE)/ Stabilin-2 is the primary systemic scavenger receptor for hyaluronan (HA), the chondroitin sulfates (CS), dermatan sulfate (DS), and nonglycosaminoglycan (GAG) ligands such as acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides, and advanced glycation end products.	Chondroitin Sulfates	154-156	stabilin 2	Homo sapiens	53-63
18499864-9	2008	For example, Hep binding to HARE was competed by DS, CS-E, AcLDL, and dextran sulfate, but not by other CS types, HA, dextran, or heparosan.	Chondroitin Sulfates	53-55	stabilin 2	Homo sapiens	28-32
18503629-0	2008	Complement activation triggered by chondroitin sulfate released by thrombin receptor-activated platelets.	Chondroitin Sulfates	35-54	coagulation factor II, thrombin	Homo sapiens	67-75
18539600-1	2008	The hyaluronic acid (HA) receptor for endocytosis (HARE) is the primary scavenger receptor for HA and chondroitin sulfates in mammals.	Chondroitin Sulfates	102-122	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	4-33
18539600-1	2008	The hyaluronic acid (HA) receptor for endocytosis (HARE) is the primary scavenger receptor for HA and chondroitin sulfates in mammals.	Chondroitin Sulfates	102-122	stabilin 2	Homo sapiens	51-55
18503629-7	2008	C1q was identified as the recognition molecule, as it bound directly to CS, and CS-triggered complement activation could be restored in C1q-depleted serum by adding purified C1q.	Chondroitin Sulfates	72-74	complement C1q A chain	Homo sapiens	0-3
18503629-7	2008	C1q was identified as the recognition molecule, as it bound directly to CS, and CS-triggered complement activation could be restored in C1q-depleted serum by adding purified C1q.	Chondroitin Sulfates	80-82	complement C1q A chain	Homo sapiens	0-3
18503629-7	2008	C1q was identified as the recognition molecule, as it bound directly to CS, and CS-triggered complement activation could be restored in C1q-depleted serum by adding purified C1q.	Chondroitin Sulfates	80-82	complement C1q A chain	Homo sapiens	136-139
18503629-7	2008	C1q was identified as the recognition molecule, as it bound directly to CS, and CS-triggered complement activation could be restored in C1q-depleted serum by adding purified C1q.	Chondroitin Sulfates	80-82	complement C1q A chain	Homo sapiens	136-139
18503629-10	2008	CONCLUSIONS: We conclude that platelets trigger complement activation in the fluid phase by releasing CS, which leads to inflammatory signals mediated by C5a.	Chondroitin Sulfates	102-104	complement C5a receptor 1	Homo sapiens	154-157
18295395-0	2008	Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-alpha-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-kappaB signal in JB6 cells.	Chondroitin Sulfates	0-19	tumor necrosis factor	Homo sapiens	69-78
18434317-1	2008	The hyaluronic acid receptor for endocytosis (HARE; also designated Stabilin-2) mediates systemic clearance of hyaluronan and chondroitin sulfates from the vascular and lymphatic circulations.	Chondroitin Sulfates	126-146	stabilin 2	Homo sapiens	4-44
18434317-1	2008	The hyaluronic acid receptor for endocytosis (HARE; also designated Stabilin-2) mediates systemic clearance of hyaluronan and chondroitin sulfates from the vascular and lymphatic circulations.	Chondroitin Sulfates	126-146	stabilin 2	Homo sapiens	46-50
18434317-1	2008	The hyaluronic acid receptor for endocytosis (HARE; also designated Stabilin-2) mediates systemic clearance of hyaluronan and chondroitin sulfates from the vascular and lymphatic circulations.	Chondroitin Sulfates	126-146	stabilin 2	Homo sapiens	68-78
18417222-7	2008	Immunolabelling of the axonal growth-associated protein GAP-43 was observed in vivo and coincided with the location of degraded chondroitin sulphate.	Chondroitin Sulfates	128-148	neuromodulin	Cricetulus griseus	56-62
18295395-0	2008	Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-alpha-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-kappaB signal in JB6 cells.	Chondroitin Sulfates	0-19	AKT serine/threonine kinase 1	Homo sapiens	151-154
18295395-0	2008	Chondroitin sulfate extracted from the Styela clava tunic suppresses TNF-alpha-induced expression of inflammatory factors, VCAM-1 and iNOS by blocking Akt/NF-kappaB signal in JB6 cells.	Chondroitin Sulfates	0-19	nuclear factor kappa B subunit 1	Homo sapiens	155-164
18295395-2	2008	Current study was performed to investigate the effects of chondroitin sulfate (CS) extracted from Styela clava tunic on TNF-alpha-induced inflammation and to elucidate the mechanism of CS on the regulation of inflammatory factors in JB6 cells.	Chondroitin Sulfates	58-77	tumor necrosis factor	Homo sapiens	120-129
18295395-2	2008	Current study was performed to investigate the effects of chondroitin sulfate (CS) extracted from Styela clava tunic on TNF-alpha-induced inflammation and to elucidate the mechanism of CS on the regulation of inflammatory factors in JB6 cells.	Chondroitin Sulfates	79-81	tumor necrosis factor	Homo sapiens	120-129
18295395-3	2008	Our results showed that CS inhibited TNF-alpha-induced NF-kappaB activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells.	Chondroitin Sulfates	24-26	tumor necrosis factor	Homo sapiens	37-46
18295395-3	2008	Our results showed that CS inhibited TNF-alpha-induced NF-kappaB activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells.	Chondroitin Sulfates	24-26	nuclear factor kappa B subunit 1	Homo sapiens	55-64
18295395-3	2008	Our results showed that CS inhibited TNF-alpha-induced NF-kappaB activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells.	Chondroitin Sulfates	24-26	vascular cell adhesion molecule 1	Homo sapiens	91-124
18295395-3	2008	Our results showed that CS inhibited TNF-alpha-induced NF-kappaB activation and subsequent vascular cell adhesion molecule 1 and inducible nitric oxide synthase expressions by blocking Akt signals in JB6 cells.	Chondroitin Sulfates	24-26	AKT serine/threonine kinase 1	Homo sapiens	185-188
18536736-8	2008	Other sulphated molecules with variable anionic charge and molecular weight exceeding 3 kDa (dextran sulphate, fucoidan, chondroitin sulphate B) inhibited IL-13-stimulated eotaxin-1 release to varying degrees.	Chondroitin Sulfates	121-141	interleukin 13	Homo sapiens	155-160
18536736-8	2008	Other sulphated molecules with variable anionic charge and molecular weight exceeding 3 kDa (dextran sulphate, fucoidan, chondroitin sulphate B) inhibited IL-13-stimulated eotaxin-1 release to varying degrees.	Chondroitin Sulfates	121-141	C-C motif chemokine ligand 11	Homo sapiens	172-181
18536737-8	2008	KEY RESULTS: CS administration reduced the concentration of the proinflammatory molecules C-reactive protein and IL-6 in serum.	Chondroitin Sulfates	13-15	C-reactive protein	Oryctolagus cuniculus	90-108
18536737-8	2008	KEY RESULTS: CS administration reduced the concentration of the proinflammatory molecules C-reactive protein and IL-6 in serum.	Chondroitin Sulfates	13-15	interleukin-6	Oryctolagus cuniculus	113-117
18536737-9	2008	Likewise, CS inhibited the expression of CCL2/monocyte chemoattractant protein (MCP)-1 and cyclooxygenase (COX)-2 in PBMC, and reduced the nuclear translocation of nuclear factor-kappaB.	Chondroitin Sulfates	10-12	C-C motif chemokine 2	Oryctolagus cuniculus	41-45
18536737-9	2008	Likewise, CS inhibited the expression of CCL2/monocyte chemoattractant protein (MCP)-1 and cyclooxygenase (COX)-2 in PBMC, and reduced the nuclear translocation of nuclear factor-kappaB.	Chondroitin Sulfates	10-12	cytochrome c oxidase subunit II	Oryctolagus cuniculus	91-113
18536737-10	2008	In the femoral lesion, CS also diminished the expression of CCL2 and COX-2, as well as the ratio of the intima/media thickness.	Chondroitin Sulfates	23-25	C-C motif chemokine 2	Oryctolagus cuniculus	60-64
18536737-10	2008	In the femoral lesion, CS also diminished the expression of CCL2 and COX-2, as well as the ratio of the intima/media thickness.	Chondroitin Sulfates	23-25	cytochrome c oxidase subunit II	Oryctolagus cuniculus	69-74
18200062-2	2008	To search for binding partner(s) of ECM1, we tested the in vitro binding activity of ECM1a, a major isoform of four ECM1 splice variants, to different skin extracellular matrix proteins (such as laminin 332, collagen type IV, and fibronectin) and polysaccharides (such as hyaluronan, heparin, and chondroitin sulfate A) with solid-phase binding assay.	Chondroitin Sulfates	297-318	extracellular matrix protein 1	Homo sapiens	85-89
18006074-0	2008	Possible role of hematopoietic CD44/chondroitin sulfate interaction in extravasation of peripheral blood CD16(-) natural killer cells into human endometrium.	Chondroitin Sulfates	36-55	Fc gamma receptor IIIa	Homo sapiens	105-109
18006074-4	2008	Recent studies have shown that CD44H binds to chondroitin sulfate (CS).	Chondroitin Sulfates	46-65	CD44 molecule (Indian blood group)	Homo sapiens	31-36
18006074-4	2008	Recent studies have shown that CD44H binds to chondroitin sulfate (CS).	Chondroitin Sulfates	67-69	CD44 molecule (Indian blood group)	Homo sapiens	31-36
18006074-5	2008	To test the hypothesis that peripheral blood CD16(-) NK cells extravasate using the CD44H/CS interaction, we have compared the binding capacity of CD44H to immobilized CS among peripheral blood lymphocyte subsets, as well as determined the menstrual cycle-dependent expression of CD44H.	Chondroitin Sulfates	90-92	Fc gamma receptor IIIa	Homo sapiens	45-49
18006074-5	2008	To test the hypothesis that peripheral blood CD16(-) NK cells extravasate using the CD44H/CS interaction, we have compared the binding capacity of CD44H to immobilized CS among peripheral blood lymphocyte subsets, as well as determined the menstrual cycle-dependent expression of CD44H.	Chondroitin Sulfates	168-170	CD44 molecule (Indian blood group)	Homo sapiens	147-152
18006074-5	2008	To test the hypothesis that peripheral blood CD16(-) NK cells extravasate using the CD44H/CS interaction, we have compared the binding capacity of CD44H to immobilized CS among peripheral blood lymphocyte subsets, as well as determined the menstrual cycle-dependent expression of CD44H.	Chondroitin Sulfates	168-170	CD44 molecule (Indian blood group)	Homo sapiens	147-152
18485243-2	2008	Elastic fibers are assembled at cell surfaces by elastin binding protein (EBP), a molecular chaperone whose function can be reversibility inhibited by chondroitin sulphate of matrix proteoglycans such as versican.	Chondroitin Sulfates	151-171	EBP cholestenol delta-isomerase	Homo sapiens	49-72
18485243-2	2008	Elastic fibers are assembled at cell surfaces by elastin binding protein (EBP), a molecular chaperone whose function can be reversibility inhibited by chondroitin sulphate of matrix proteoglycans such as versican.	Chondroitin Sulfates	151-171	EBP cholestenol delta-isomerase	Homo sapiens	74-77
18485243-2	2008	Elastic fibers are assembled at cell surfaces by elastin binding protein (EBP), a molecular chaperone whose function can be reversibility inhibited by chondroitin sulphate of matrix proteoglycans such as versican.	Chondroitin Sulfates	151-171	versican	Homo sapiens	204-212
17901089-0	2008	Natural chondroitin sulphates increase aggregation of proteoglycan complexes and decrease ADAMTS-5 expression in interleukin 1 beta-treated chondrocytes.	Chondroitin Sulfates	8-29	LOW QUALITY PROTEIN: A disintegrin and metalloproteinase with thrombospondin motifs 5	Oryctolagus cuniculus	90-98
17901089-0	2008	Natural chondroitin sulphates increase aggregation of proteoglycan complexes and decrease ADAMTS-5 expression in interleukin 1 beta-treated chondrocytes.	Chondroitin Sulfates	8-29	interleukin-1 beta	Oryctolagus cuniculus	113-131
17901089-6	2008	The addition of CS to IL1 beta-treated cells inhibited in part the disaggregation of sulphated PGs induced by IL1 beta.	Chondroitin Sulfates	16-18	interleukin-1 beta	Oryctolagus cuniculus	22-30
17901089-6	2008	The addition of CS to IL1 beta-treated cells inhibited in part the disaggregation of sulphated PGs induced by IL1 beta.	Chondroitin Sulfates	16-18	interleukin-1 beta	Oryctolagus cuniculus	110-118
17901089-7	2008	This inhibitory effect of CS is associated with a significant decrease in ADAMTS-5 expression at the mRNA and protein levels.	Chondroitin Sulfates	26-28	LOW QUALITY PROTEIN: A disintegrin and metalloproteinase with thrombospondin motifs 5	Oryctolagus cuniculus	74-82
17901089-10	2008	This beneficial effect of CS in IL1 beta-treated cells is associated with decreased expression of ADAMTS-5.	Chondroitin Sulfates	26-28	interleukin-1 beta	Oryctolagus cuniculus	32-40
17901089-10	2008	This beneficial effect of CS in IL1 beta-treated cells is associated with decreased expression of ADAMTS-5.	Chondroitin Sulfates	26-28	LOW QUALITY PROTEIN: A disintegrin and metalloproteinase with thrombospondin motifs 5	Oryctolagus cuniculus	98-106
17540369-0	2008	Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3.	Chondroitin Sulfates	10-29	neurotrophin 3	Rattus norvegicus	191-205
18316376-2	2008	Although an additional ChSy family member, called chondroitin sulfate glucuronyltransferase (CSGlcA-T), has been identified, its involvement in chondroitin polymerization remains unclear because it possesses only glucuronyltransferase II activity responsible for the elongation of chondroitin sulfate (CS) chains.	Chondroitin Sulfates	50-69	chondroitin polymerizing factor 2	Homo sapiens	93-101
18316376-2	2008	Although an additional ChSy family member, called chondroitin sulfate glucuronyltransferase (CSGlcA-T), has been identified, its involvement in chondroitin polymerization remains unclear because it possesses only glucuronyltransferase II activity responsible for the elongation of chondroitin sulfate (CS) chains.	Chondroitin Sulfates	93-95	chondroitin polymerizing factor 2	Homo sapiens	50-91
18316376-5	2008	Moreover, overexpression of CSGlcA-T increased the amount of CS in HeLa cells, whereas the RNA interference of CSGlcA-T resulted in a reduction of the amount of CS in the cells.	Chondroitin Sulfates	61-63	chondroitin polymerizing factor 2	Homo sapiens	28-36
18285341-0	2008	Distinct effects of N-acetylgalactosamine-4-sulfatase and galactose-6-sulfatase expression on chondroitin sulfates.	Chondroitin Sulfates	94-114	arylsulfatase B	Homo sapiens	20-53
18285341-1	2008	The sulfatase enzymes, N-acetylgalactosamine-4-sulfatase (arylsulfatase B (ASB)) and galactose-6-sulfatase (GALNS) hydrolyze sulfate groups of CS.	Chondroitin Sulfates	143-145	arylsulfatase family member H	Homo sapiens	4-13
18285341-1	2008	The sulfatase enzymes, N-acetylgalactosamine-4-sulfatase (arylsulfatase B (ASB)) and galactose-6-sulfatase (GALNS) hydrolyze sulfate groups of CS.	Chondroitin Sulfates	143-145	arylsulfatase B	Homo sapiens	23-56
18285341-1	2008	The sulfatase enzymes, N-acetylgalactosamine-4-sulfatase (arylsulfatase B (ASB)) and galactose-6-sulfatase (GALNS) hydrolyze sulfate groups of CS.	Chondroitin Sulfates	143-145	arylsulfatase B	Homo sapiens	75-78
18285341-1	2008	The sulfatase enzymes, N-acetylgalactosamine-4-sulfatase (arylsulfatase B (ASB)) and galactose-6-sulfatase (GALNS) hydrolyze sulfate groups of CS.	Chondroitin Sulfates	143-145	arylsulfatase family member H	Homo sapiens	47-56
18285341-1	2008	The sulfatase enzymes, N-acetylgalactosamine-4-sulfatase (arylsulfatase B (ASB)) and galactose-6-sulfatase (GALNS) hydrolyze sulfate groups of CS.	Chondroitin Sulfates	143-145	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	108-113
18285341-5	2008	Following silencing of ASB or GALNS, total sGAG, C4S, and CS increased significantly.	Chondroitin Sulfates	49-52	arylsulfatase B	Homo sapiens	23-26
18285341-5	2008	Following silencing of ASB or GALNS, total sGAG, C4S, and CS increased significantly.	Chondroitin Sulfates	58-60	arylsulfatase B	Homo sapiens	23-26
18285341-5	2008	Following silencing of ASB or GALNS, total sGAG, C4S, and CS increased significantly.	Chondroitin Sulfates	58-60	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	30-35
18285341-10	2008	mRNA expression of core proteins of the CS-containing proteoglycans, syndecan-1 and decorin, was significantly up-regulated following overexpression of ASB and GALNS.	Chondroitin Sulfates	40-42	syndecan 1	Homo sapiens	69-79
18285341-10	2008	mRNA expression of core proteins of the CS-containing proteoglycans, syndecan-1 and decorin, was significantly up-regulated following overexpression of ASB and GALNS.	Chondroitin Sulfates	40-42	arylsulfatase B	Homo sapiens	152-155
18285341-10	2008	mRNA expression of core proteins of the CS-containing proteoglycans, syndecan-1 and decorin, was significantly up-regulated following overexpression of ASB and GALNS.	Chondroitin Sulfates	40-42	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	160-165
18285341-11	2008	Soluble syndecan-1 protein increased following increases in ASB and GALNS and reduced following silencing, inversely to changes in CS.	Chondroitin Sulfates	131-133	syndecan 1	Homo sapiens	8-18
18285341-12	2008	These findings demonstrate that modification of expression of the lysosomal sulfatases ASB and GALNS regulates the content of CSs.	Chondroitin Sulfates	126-129	arylsulfatase B	Homo sapiens	87-90
18285341-12	2008	These findings demonstrate that modification of expression of the lysosomal sulfatases ASB and GALNS regulates the content of CSs.	Chondroitin Sulfates	126-129	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	95-100
18237557-2	2008	GalNAc 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) transfers sulfate to position 6 of GalNAc(4SO4) residues of CS.	Chondroitin Sulfates	113-115	carbohydrate sulfotransferase 15	Mus musculus	0-37
18237557-2	2008	GalNAc 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) transfers sulfate to position 6 of GalNAc(4SO4) residues of CS.	Chondroitin Sulfates	113-115	carbohydrate sulfotransferase 15	Mus musculus	39-51
18364051-3	2008	VAR2CSA appears to be the main ligand responsible for adhesion to chondroitin sulphate A (CSA).	Chondroitin Sulfates	66-88	chorionic somatomammotropin hormone 1	Homo sapiens	4-7
17851735-3	2008	Collagen-based coatings and scaffolds have been enhanced by the incorporation of the glycosaminoglycan chondroitin sulphate (CS), however the proteglycan biglycan, which is found in bone and contains glycosaminoglycan chains consisting of CS, has not been used as a biomaterial component.	Chondroitin Sulfates	239-241	biglycan	Mus musculus	154-162
17996021-0	2008	A highly sulfated chondroitin sulfate preparation, CS-E, prevents excitatory amino acid-induced neuronal cell death.	Chondroitin Sulfates	18-37	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	51-55
17996021-5	2008	Pre-administration of a highly sulfated CS preparation, CS-E, significantly reduced neuronal cell death induced by not only NMDA but also (S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid or kainate.	Chondroitin Sulfates	40-42	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	56-60
17980567-7	2008	The differential expression of chondroitin sulfate, dermatan sulfate and heparan sulfate chains was determined by analyzing the mRNA expression of EXTL2 (alpha-1,4-N-acetylhexosaminyltransferase), GalNAcT (beta-1,4-N-acetylgalactosaminyltransferase), and GlcAC5E (glucuronyl C5-epimerase) as they represent crucial enzymes in GAG biosynthesis.	Chondroitin Sulfates	31-50	exostosin like glycosyltransferase 2	Homo sapiens	147-152
18299424-7	2008	The CD44 protein was also present on caudal epididymal spermatozoa that were highly stimulated by CS in vitro implicating a role in fertilisation for CS and CD44.	Chondroitin Sulfates	98-100	CD44 molecule (Indian blood group)	Rattus norvegicus	4-8
18299424-7	2008	The CD44 protein was also present on caudal epididymal spermatozoa that were highly stimulated by CS in vitro implicating a role in fertilisation for CS and CD44.	Chondroitin Sulfates	150-152	CD44 molecule (Indian blood group)	Rattus norvegicus	4-8
18247611-5	2008	Bikunin is posttranslationally modified with a chondroitin sulfate (CS) chain, O-linked to a serine residue of the core protein.	Chondroitin Sulfates	47-66	alpha-1-microglobulin/bikunin precursor	Homo sapiens	0-7
18247611-5	2008	Bikunin is posttranslationally modified with a chondroitin sulfate (CS) chain, O-linked to a serine residue of the core protein.	Chondroitin Sulfates	68-70	alpha-1-microglobulin/bikunin precursor	Homo sapiens	0-7
18247611-6	2008	Recent studies have shown that the CS chain of bikunin plays an important role in the physiological and pathological functions of this PG.	Chondroitin Sulfates	35-37	alpha-1-microglobulin/bikunin precursor	Homo sapiens	47-54
18024155-8	2008	Recombinant bee hyaluronidase efficiently degrades 6-S-chondroitin sulfate (chondroitin sulfate C) as well as 4-S-chondroitin sulfate (chondroitin sulfate A), the latter to a lesser extent.	Chondroitin Sulfates	76-97	hyaluronidase	Apis mellifera	16-29
18024155-8	2008	Recombinant bee hyaluronidase efficiently degrades 6-S-chondroitin sulfate (chondroitin sulfate C) as well as 4-S-chondroitin sulfate (chondroitin sulfate A), the latter to a lesser extent.	Chondroitin Sulfates	55-74	hyaluronidase	Apis mellifera	16-29
18024155-8	2008	Recombinant bee hyaluronidase efficiently degrades 6-S-chondroitin sulfate (chondroitin sulfate C) as well as 4-S-chondroitin sulfate (chondroitin sulfate A), the latter to a lesser extent.	Chondroitin Sulfates	135-156	hyaluronidase	Apis mellifera	16-29
17983423-4	2008	Cultured rabbit chondrocytes were stimulated with interleukin-1beta (IL-1beta) in presence of chondroitin sulfate.	Chondroitin Sulfates	94-113	interleukin-1 beta	Oryctolagus cuniculus	50-67
18789149-12	2008	Interestingly, anti-chondroitin sulphate C IgM antibody levels showed inverse correlation both with the Disease Activity Score (DAS) 28 scores and C-reactive protein (CRP) levels in rheumatoid arthritis.	Chondroitin Sulfates	20-40	C-reactive protein	Homo sapiens	147-165
18789149-12	2008	Interestingly, anti-chondroitin sulphate C IgM antibody levels showed inverse correlation both with the Disease Activity Score (DAS) 28 scores and C-reactive protein (CRP) levels in rheumatoid arthritis.	Chondroitin Sulfates	20-40	C-reactive protein	Homo sapiens	167-170
17983423-0	2008	Chondroitin sulfate inhibits the nuclear translocation of nuclear factor-kappaB in interleukin-1beta-stimulated chondrocytes.	Chondroitin Sulfates	0-19	interleukin-1 beta	Oryctolagus cuniculus	83-100
17965432-0	2008	Overexpression of the 3"-phosphoadenosine 5"-phosphosulfate (PAPS) transporter 1 increases sulfation of chondroitin sulfate in the apical pathway of MDCK II cells.	Chondroitin Sulfates	104-123	solute carrier family 35 member B2	Canis lupus familiaris	22-80
17983423-4	2008	Cultured rabbit chondrocytes were stimulated with interleukin-1beta (IL-1beta) in presence of chondroitin sulfate.	Chondroitin Sulfates	94-113	interleukin-1 beta	Oryctolagus cuniculus	69-77
17983423-6	2008	The effect of chondroitin sulfate on IL-1beta activation of extracellular signal-regulated kinase 1/2 (Erk1/2) and p38MAPK was documented by immunoblot.	Chondroitin Sulfates	14-33	interleukin-1 beta	Oryctolagus cuniculus	37-45
17983423-8	2008	Chondroitin sulfate reduced IL-1beta-induced NF-kappaB nuclear translocation, but not AP-1 translocation, it decreased IL-1beta-induced phosphorylation of Erk1/2 and abrogated p38MAPK phosphorylation, but did not prevent IL-1beta-induced increase in nitrite.	Chondroitin Sulfates	0-19	interleukin-1 beta	Oryctolagus cuniculus	28-36
17983423-8	2008	Chondroitin sulfate reduced IL-1beta-induced NF-kappaB nuclear translocation, but not AP-1 translocation, it decreased IL-1beta-induced phosphorylation of Erk1/2 and abrogated p38MAPK phosphorylation, but did not prevent IL-1beta-induced increase in nitrite.	Chondroitin Sulfates	0-19	interleukin-1 beta	Oryctolagus cuniculus	119-127
17983423-8	2008	Chondroitin sulfate reduced IL-1beta-induced NF-kappaB nuclear translocation, but not AP-1 translocation, it decreased IL-1beta-induced phosphorylation of Erk1/2 and abrogated p38MAPK phosphorylation, but did not prevent IL-1beta-induced increase in nitrite.	Chondroitin Sulfates	0-19	interleukin-1 beta	Oryctolagus cuniculus	119-127
18585473-5	2008	Heparin, heparan sulfate and chondroitin sulfate inhibited PHEX catalytic activity, however among them, heparin presented the highest inhibitory activity (Ki=2.5+/-0.2 nM).	Chondroitin Sulfates	29-48	phosphate regulating endopeptidase homolog X-linked	Homo sapiens	59-63
18956330-1	2008	The chondroitin sulfate proteoglycan (PG) PG-M/versican is known to be a primary component of the vertebrate embryonic extracellular matrix and, in the mouse, functional abrogation of the versican gene leads to severe cardiovascular malformations and embryonic lethality.	Chondroitin Sulfates	4-23	versican	Mus musculus	47-55
18956330-1	2008	The chondroitin sulfate proteoglycan (PG) PG-M/versican is known to be a primary component of the vertebrate embryonic extracellular matrix and, in the mouse, functional abrogation of the versican gene leads to severe cardiovascular malformations and embryonic lethality.	Chondroitin Sulfates	4-23	versican	Mus musculus	188-196
17625924-0	2008	Chondroitin sulfate modulation of matrix and inflammatory gene expression in IL-1beta-stimulated chondrocytes--study in hypoxic alginate bead cultures.	Chondroitin Sulfates	0-19	interleukin 1 beta	Bos taurus	77-85
17706452-2	2008	The aim of the present study was to examine the possible participation of various glycosaminoglycans, i.e. chondroitin sulfate, dermatan sulfate and heparin on basal and FGF-2-induced growth of WM9 and M5 human metastatic melanoma cells.	Chondroitin Sulfates	107-126	fibroblast growth factor 2	Homo sapiens	170-175
17706452-5	2008	Heparin capably restored their growth, and unexpectedly exogenous chondroitin sulfate to WM9 and both chondroitin sulfate and dermatan sulfate to M5 cells allowed FGF-2 mitogenic stimulation.	Chondroitin Sulfates	66-85	fibroblast growth factor 2	Homo sapiens	163-168
17706452-7	2008	The specific tyrosine kinase inhibitor, genistein completely blocked the effects of FGF-2 and glycosaminoglycans on melanoma proliferation whereas the use of the neutralizing antibody for FGF-2 showed that the mitogenic effect of chondroitin sulfate involves the interaction of FGF-2 with its receptors.	Chondroitin Sulfates	230-249	fibroblast growth factor 2	Homo sapiens	188-193
17706452-7	2008	The specific tyrosine kinase inhibitor, genistein completely blocked the effects of FGF-2 and glycosaminoglycans on melanoma proliferation whereas the use of the neutralizing antibody for FGF-2 showed that the mitogenic effect of chondroitin sulfate involves the interaction of FGF-2 with its receptors.	Chondroitin Sulfates	230-249	fibroblast growth factor 2	Homo sapiens	188-193
17625924-1	2008	OBJECTIVE: To determine the effect of avian chondroitin sulfate (CS) on interleukin-1beta (IL-1beta)-induced expression of genes related to catabolic, anabolic and inflammatory aspects in chondrocytes cultured in hypoxic alginate beads.	Chondroitin Sulfates	44-63	interleukin 1 beta	Bos taurus	72-89
17625924-1	2008	OBJECTIVE: To determine the effect of avian chondroitin sulfate (CS) on interleukin-1beta (IL-1beta)-induced expression of genes related to catabolic, anabolic and inflammatory aspects in chondrocytes cultured in hypoxic alginate beads.	Chondroitin Sulfates	44-63	interleukin 1 beta	Bos taurus	91-99
17625924-1	2008	OBJECTIVE: To determine the effect of avian chondroitin sulfate (CS) on interleukin-1beta (IL-1beta)-induced expression of genes related to catabolic, anabolic and inflammatory aspects in chondrocytes cultured in hypoxic alginate beads.	Chondroitin Sulfates	65-67	interleukin 1 beta	Bos taurus	72-89
17625924-1	2008	OBJECTIVE: To determine the effect of avian chondroitin sulfate (CS) on interleukin-1beta (IL-1beta)-induced expression of genes related to catabolic, anabolic and inflammatory aspects in chondrocytes cultured in hypoxic alginate beads.	Chondroitin Sulfates	65-67	interleukin 1 beta	Bos taurus	91-99
17625924-6	2008	RESULTS: CS decreased IL-1beta-induced expression of matrix metalloproteases-1, -3 and -13 and aggrecanases-1 and -2.	Chondroitin Sulfates	9-11	interleukin 1 beta	Bos taurus	22-30
17625924-6	2008	RESULTS: CS decreased IL-1beta-induced expression of matrix metalloproteases-1, -3 and -13 and aggrecanases-1 and -2.	Chondroitin Sulfates	9-11	ADAM metallopeptidase with thrombospondin type 1 motif 4	Bos taurus	53-116
18667340-6	2008	CS and its disaccharides reduce NF-kappaB nuclear translocation, probably by diminishing extracellular signal-regulated kinase1/2, p38mitogen-activated protein kinase and c-Jun N-terminal kinase activation.	Chondroitin Sulfates	0-2	mitogen-activated protein kinase 3	Homo sapiens	89-129
17625924-8	2008	Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA levels were found to be reduced by CS treatment.	Chondroitin Sulfates	108-110	nitric oxide synthase 2	Bos taurus	0-31
17625924-8	2008	Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA levels were found to be reduced by CS treatment.	Chondroitin Sulfates	108-110	nitric oxide synthase 2	Bos taurus	33-37
17625924-8	2008	Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA levels were found to be reduced by CS treatment.	Chondroitin Sulfates	108-110	prostaglandin-endoperoxide synthase 2	Bos taurus	43-59
17625924-8	2008	Inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) mRNA levels were found to be reduced by CS treatment.	Chondroitin Sulfates	108-110	prostaglandin-endoperoxide synthase 2	Bos taurus	61-66
17625924-10	2008	Furthermore, CS was capable of counteracting IL-1beta-depressed expression of transforming growth factor-beta (TGF-beta) receptors.	Chondroitin Sulfates	13-15	interleukin 1 beta	Bos taurus	45-53
18086919-2	2007	Chondroitin sulfate proteoglycan (NG2)-expressing progenitor cells of the subventricular zone (SVZ) show no significant difference in density and proliferation between Cdk2(-/-) and wild-type mice at perinatal ages and are reduced only in adult Cdk2(-/-) mice.	Chondroitin Sulfates	0-19	chondroitin sulfate proteoglycan 4	Mus musculus	34-37
18056470-4	2007	Chondroitin sulfate, but not heparan or dermatan sulfate, showed competitive inhibition (K(d), 1.1 x 10(-7) mol/L) of binding of PIF to the receptor, suggesting an interaction with the sulfated oligosaccharide chains.	Chondroitin Sulfates	0-19	Pif	Mus musculus	129-132
18667340-6	2008	CS and its disaccharides reduce NF-kappaB nuclear translocation, probably by diminishing extracellular signal-regulated kinase1/2, p38mitogen-activated protein kinase and c-Jun N-terminal kinase activation.	Chondroitin Sulfates	0-2	mitogen-activated protein kinase 14	Homo sapiens	131-166
17893095-1	2007	N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) transfers sulfate to position 6 of GalNAc(4SO(4)) residues in chondroitin sulfate (CS).	Chondroitin Sulfates	130-149	carbohydrate sulfotransferase 15	Homo sapiens	54-66
17893095-1	2007	N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) transfers sulfate to position 6 of GalNAc(4SO(4)) residues in chondroitin sulfate (CS).	Chondroitin Sulfates	151-153	carbohydrate sulfotransferase 15	Homo sapiens	54-66
17893095-8	2007	These observations indicate that the recombinant squid GalNAc4S-6ST is a useful enzyme for preparing a unique chondroitin sulfate containing the E-D hybrid tetrasaccharide structure.	Chondroitin Sulfates	110-129	carbohydrate sulfotransferase 15	Homo sapiens	55-67
17952091-0	2007	Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human.	Chondroitin Sulfates	52-71	solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1	Mus musculus	29-36
17885094-0	2007	Chondroitin sulfate protects SH-SY5Y cells from oxidative stress by inducing heme oxygenase-1 via phosphatidylinositol 3-kinase/Akt.	Chondroitin Sulfates	0-19	heme oxygenase 1	Homo sapiens	77-93
17885094-0	2007	Chondroitin sulfate protects SH-SY5Y cells from oxidative stress by inducing heme oxygenase-1 via phosphatidylinositol 3-kinase/Akt.	Chondroitin Sulfates	0-19	AKT serine/threonine kinase 1	Homo sapiens	128-131
17885094-7	2007	CS also increased the expression of phosphorylated Akt and heme oxygenase-1 by 2-fold.	Chondroitin Sulfates	0-2	AKT serine/threonine kinase 1	Homo sapiens	51-54
17885094-7	2007	CS also increased the expression of phosphorylated Akt and heme oxygenase-1 by 2-fold.	Chondroitin Sulfates	0-2	heme oxygenase 1	Homo sapiens	59-75
17885094-9	2007	Taken together, these results show that CS can protect SH-SY5Y cells under oxidative stress conditions by activating protein kinase C, which phosphorylates Akt that, via the phosphatidylinositol 3-kinase/Akt pathway, induces the synthesis of the antioxidant protein heme oxygenase-1.	Chondroitin Sulfates	40-42	AKT serine/threonine kinase 1	Homo sapiens	156-159
17885094-9	2007	Taken together, these results show that CS can protect SH-SY5Y cells under oxidative stress conditions by activating protein kinase C, which phosphorylates Akt that, via the phosphatidylinositol 3-kinase/Akt pathway, induces the synthesis of the antioxidant protein heme oxygenase-1.	Chondroitin Sulfates	40-42	AKT serine/threonine kinase 1	Homo sapiens	204-207
17885094-9	2007	Taken together, these results show that CS can protect SH-SY5Y cells under oxidative stress conditions by activating protein kinase C, which phosphorylates Akt that, via the phosphatidylinositol 3-kinase/Akt pathway, induces the synthesis of the antioxidant protein heme oxygenase-1.	Chondroitin Sulfates	40-42	heme oxygenase 1	Homo sapiens	266-282
17936096-6	2007	Interestingly, the natural substrate HS did not cause a secondary structural change in the enzyme, whereas heparin and chondroitin sulfate did, both of which also exhibited similar high affinity binding to 3-OST-3A compared to HS as detected by isothermal fluorescence titrations.	Chondroitin Sulfates	119-138	heparan sulfate-glucosamine 3-sulfotransferase 3A1	Homo sapiens	206-214
17952091-5	2007	The solute carrier-35 D1 (SLC35D1) gene (SLC35D1) encodes an endoplasmic reticulum nucleotide-sugar transporter (NST) that might transport substrates needed for chondroitin sulfate biosynthesis.	Chondroitin Sulfates	161-180	solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1	Mus musculus	4-24
17952091-5	2007	The solute carrier-35 D1 (SLC35D1) gene (SLC35D1) encodes an endoplasmic reticulum nucleotide-sugar transporter (NST) that might transport substrates needed for chondroitin sulfate biosynthesis.	Chondroitin Sulfates	161-180	solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1	Mus musculus	26-33
17952091-5	2007	The solute carrier-35 D1 (SLC35D1) gene (SLC35D1) encodes an endoplasmic reticulum nucleotide-sugar transporter (NST) that might transport substrates needed for chondroitin sulfate biosynthesis.	Chondroitin Sulfates	161-180	solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1	Mus musculus	41-48
17924631-4	2007	The combined methods are used in conjunction with more traditional NMR structural data to determine the solution structure of a pentasaccharide, GalNAc6S(beta1-4)GlcA(beta1-3)GalNAc4S(beta1-4)GlcA(beta1-3)GalNAc4S-ol, derived by enzymatic hydrolysis of chondroitin sulfate.	Chondroitin Sulfates	253-272	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	145-153
17702986-0	2007	Disruption of heparan and chondroitin sulfate signaling enhances mesenchymal stem cell-derived osteogenic differentiation via bone morphogenetic protein signaling pathways.	Chondroitin Sulfates	26-45	bone morphogenetic protein 1	Homo sapiens	126-152
17702986-3	2007	Here, we show that the abundant cell surface GAGs, HS and CS, are secreted in proteoglycan complexes that directly regulate the bone morphogenetic protein (BMP)-mediated differentiation of hMSCs into osteoblasts.	Chondroitin Sulfates	58-60	bone morphogenetic protein 1	Homo sapiens	128-154
17702986-3	2007	Here, we show that the abundant cell surface GAGs, HS and CS, are secreted in proteoglycan complexes that directly regulate the bone morphogenetic protein (BMP)-mediated differentiation of hMSCs into osteoblasts.	Chondroitin Sulfates	58-60	bone morphogenetic protein 1	Homo sapiens	156-159
17702986-5	2007	When digested separately, depletion of HS and CS chains did not effect hMSC proliferation but rather increased BMP bioactivity through SMAD1/5/8 intracellular signaling at the same time as increasing canonical Wnt signaling through LEF1 activation.	Chondroitin Sulfates	46-48	bone morphogenetic protein 1	Homo sapiens	111-114
17702986-6	2007	Long-term culturing of cells in HS- and CS-degrading enzymes also increased bone nodule formation, calcium accumulation, and the expression of such osteoblast markers as alkaline phosphatase, RUNX2, and osteocalcin.	Chondroitin Sulfates	40-42	RUNX family transcription factor 2	Homo sapiens	192-197
17702986-6	2007	Long-term culturing of cells in HS- and CS-degrading enzymes also increased bone nodule formation, calcium accumulation, and the expression of such osteoblast markers as alkaline phosphatase, RUNX2, and osteocalcin.	Chondroitin Sulfates	40-42	bone gamma-carboxyglutamate protein	Homo sapiens	203-214
17702986-7	2007	Thus, the enzymatic disruption of HS and CS chains on cell surface proteoglycans alters BMP and Wnt activity so as to enhance the lineage commitment and osteogenic differentiation of hMSCs.	Chondroitin Sulfates	41-43	bone morphogenetic protein 1	Homo sapiens	88-91
17717144-0	2007	Antibody GD3G7 selected against embryonic glycosaminoglycans defines chondroitin sulfate-E domains highly up-regulated in ovarian cancer and involved in vascular endothelial growth factor binding.	Chondroitin Sulfates	69-88	vascular endothelial growth factor A	Homo sapiens	153-187
17924631-4	2007	The combined methods are used in conjunction with more traditional NMR structural data to determine the solution structure of a pentasaccharide, GalNAc6S(beta1-4)GlcA(beta1-3)GalNAc4S(beta1-4)GlcA(beta1-3)GalNAc4S-ol, derived by enzymatic hydrolysis of chondroitin sulfate.	Chondroitin Sulfates	253-272	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	154-161
17924631-4	2007	The combined methods are used in conjunction with more traditional NMR structural data to determine the solution structure of a pentasaccharide, GalNAc6S(beta1-4)GlcA(beta1-3)GalNAc4S(beta1-4)GlcA(beta1-3)GalNAc4S-ol, derived by enzymatic hydrolysis of chondroitin sulfate.	Chondroitin Sulfates	253-272	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	167-174
17924631-4	2007	The combined methods are used in conjunction with more traditional NMR structural data to determine the solution structure of a pentasaccharide, GalNAc6S(beta1-4)GlcA(beta1-3)GalNAc4S(beta1-4)GlcA(beta1-3)GalNAc4S-ol, derived by enzymatic hydrolysis of chondroitin sulfate.	Chondroitin Sulfates	253-272	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	184-191
17572406-8	2007	The ability of chondroitinase to degrade hyaluronan is likely to result in greater matrix disruption than the degradation of chondroitin sulphate alone.	Chondroitin Sulfates	125-145	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	15-29
17680989-8	2007	These results indicate that a specific sulfation motif, in particular the CS-E tetrasaccharide unit, represents a key structural determinant for activation of midkine, pleiotrophin and brain-derived neurotrophic factor-mediated signaling, and is required for the neuritogenic activity of CS in dopaminergic neurons.	Chondroitin Sulfates	74-76	pleiotrophin	Homo sapiens	168-180
17680989-8	2007	These results indicate that a specific sulfation motif, in particular the CS-E tetrasaccharide unit, represents a key structural determinant for activation of midkine, pleiotrophin and brain-derived neurotrophic factor-mediated signaling, and is required for the neuritogenic activity of CS in dopaminergic neurons.	Chondroitin Sulfates	74-76	brain derived neurotrophic factor	Homo sapiens	185-218
17635914-7	2007	For XT-I we found an increased expression in parallel with an elevated chondroitin sulfate-GAG content after incubation with TGF-beta(1) and after mechanical stretch.	Chondroitin Sulfates	71-90	xylosyltransferase 1	Homo sapiens	4-8
17635914-7	2007	For XT-I we found an increased expression in parallel with an elevated chondroitin sulfate-GAG content after incubation with TGF-beta(1) and after mechanical stretch.	Chondroitin Sulfates	71-90	transforming growth factor beta 1	Homo sapiens	125-136
17635914-9	2007	Usage of XT-I small interfering RNA could specifically block the increased XT-I expression under mechanical stress and resulted in a significantly reduced chondroitin sulfate-GAG content.	Chondroitin Sulfates	155-174	xylosyltransferase 1	Homo sapiens	9-13
17458871-2	2007	ARSB is a lysosomal enzyme involved in the degradation of the glycosaminoglycans (GAG) dermatan and chondroitin sulfate.	Chondroitin Sulfates	100-119	arylsulfatase B	Homo sapiens	0-4
17597120-4	2007	While many different CSPGs are expressed after spinal cord injury (SCI) they all rely on the same enzymes, xylosyltransferase-I and -II (XT-I, XT-II) and chondroitin 4-sulfotransferase (C4ST) to add the repulsive chondroitin sulfate side chains to their core proteins.	Chondroitin Sulfates	213-232	xylosyltransferase 1	Homo sapiens	107-135
17597120-4	2007	While many different CSPGs are expressed after spinal cord injury (SCI) they all rely on the same enzymes, xylosyltransferase-I and -II (XT-I, XT-II) and chondroitin 4-sulfotransferase (C4ST) to add the repulsive chondroitin sulfate side chains to their core proteins.	Chondroitin Sulfates	213-232	xylosyltransferase 1	Homo sapiens	137-141
17597120-4	2007	While many different CSPGs are expressed after spinal cord injury (SCI) they all rely on the same enzymes, xylosyltransferase-I and -II (XT-I, XT-II) and chondroitin 4-sulfotransferase (C4ST) to add the repulsive chondroitin sulfate side chains to their core proteins.	Chondroitin Sulfates	213-232	carbohydrate sulfotransferase 11	Homo sapiens	154-184
17640987-7	2007	Instead, we show that CNP increases expression of enzymes involved in chondroitin sulfate synthesis, a required step in the production of cartilage glycosaminoglycans.	Chondroitin Sulfates	70-89	natriuretic peptide type C	Mus musculus	22-25
17385225-1	2007	Basic fibroblast growth factor (bFGF) was immobilized onto quartz slides and collagen films by assembly with chondroitin sulfate (CS) in a layer-by-layer (LBL) manner.	Chondroitin Sulfates	109-128	fibroblast growth factor 2	Homo sapiens	0-30
17385225-1	2007	Basic fibroblast growth factor (bFGF) was immobilized onto quartz slides and collagen films by assembly with chondroitin sulfate (CS) in a layer-by-layer (LBL) manner.	Chondroitin Sulfates	109-128	fibroblast growth factor 2	Homo sapiens	32-36
17385225-1	2007	Basic fibroblast growth factor (bFGF) was immobilized onto quartz slides and collagen films by assembly with chondroitin sulfate (CS) in a layer-by-layer (LBL) manner.	Chondroitin Sulfates	130-132	fibroblast growth factor 2	Homo sapiens	0-30
17385225-1	2007	Basic fibroblast growth factor (bFGF) was immobilized onto quartz slides and collagen films by assembly with chondroitin sulfate (CS) in a layer-by-layer (LBL) manner.	Chondroitin Sulfates	130-132	fibroblast growth factor 2	Homo sapiens	32-36
17385225-6	2007	In vitro incubation of the CS/bFGF multilayers in PBS showed that approximately 30% of the incorporated bFGF was released within 8 days.	Chondroitin Sulfates	27-29	fibroblast growth factor 2	Homo sapiens	104-108
17588949-8	2007	Using affinity co-electrophoresis, we showed that COMP/TSP5, in its calcium-replete conformation, bound to heparin, chondroitin sulfates, and heparan sulfate; this binding was reduced with EDTA treatment of COMP/TSP5.	Chondroitin Sulfates	116-136	cartilage oligomeric matrix protein	Homo sapiens	50-59
17588949-8	2007	Using affinity co-electrophoresis, we showed that COMP/TSP5, in its calcium-replete conformation, bound to heparin, chondroitin sulfates, and heparan sulfate; this binding was reduced with EDTA treatment of COMP/TSP5.	Chondroitin Sulfates	116-136	cartilage oligomeric matrix protein	Homo sapiens	55-59
17492940-9	2007	Furthermore, these results suggest that invariant chain-chondroitin sulfate may play an important role in the generation of cell-surface pools of invariant chain that can serve as receptors for CD44 and macrophage migration inhibitory factor.	Chondroitin Sulfates	56-75	CD44 molecule (Indian blood group)	Homo sapiens	194-198
17492940-9	2007	Furthermore, these results suggest that invariant chain-chondroitin sulfate may play an important role in the generation of cell-surface pools of invariant chain that can serve as receptors for CD44 and macrophage migration inhibitory factor.	Chondroitin Sulfates	56-75	macrophage migration inhibitory factor	Homo sapiens	203-241
17585905-3	2007	Combining such a prior peripheral nerve conditioning lesion with the infusion of antibodies that neutralize the growth inhibitory effects of the NG2 chondroitin sulfate proteoglycan promotes sensory axon growth through the glial scar and into the white matter of the dorsal columns.	Chondroitin Sulfates	149-168	chondroitin sulfate proteoglycan 4	Homo sapiens	145-148
17675795-0	2007	Bovine lactoferrin stimulates anchorage-independent cell growth via membrane-associated chondroitin sulfate and heparan sulfate proteoglycans in PC12 cells.	Chondroitin Sulfates	88-107	lactotransferrin	Rattus norvegicus	7-18
17470431-4	2007	Our data indicate that this interaction is mediated largely through the binding of glycosaminoglycans (specifically chondroitin 6-sulfate) of aggrecan to binding sites in the thrombospondin type 1 motif and spacer domains of ADAMTS-4 to form a complex with an improved binding affinity for TIMP-3 over free ADAMTS-4.	Chondroitin Sulfates	116-137	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	225-233
17522116-4	2007	Versican was the predominant CS-containing proteoglycan in the lung and decreased from 19.9 +/- 2.7 arbitrary units at 90 days GA to 6.0 +/- 0.5 arbitrary units at 142 days GA, in close association (P &lt; 0.05) with the reduction in tissue volumes (from 66.0 +/- 4.6 to 25.3 +/- 1.5% at 142 days); similar reductions occurred for both chondroitin-6-sulfate and chondroitin-4-sulfate CS side chains.	Chondroitin Sulfates	29-31	versican core protein	Ovis aries	0-8
17522116-4	2007	Versican was the predominant CS-containing proteoglycan in the lung and decreased from 19.9 +/- 2.7 arbitrary units at 90 days GA to 6.0 +/- 0.5 arbitrary units at 142 days GA, in close association (P &lt; 0.05) with the reduction in tissue volumes (from 66.0 +/- 4.6 to 25.3 +/- 1.5% at 142 days); similar reductions occurred for both chondroitin-6-sulfate and chondroitin-4-sulfate CS side chains.	Chondroitin Sulfates	336-357	versican core protein	Ovis aries	0-8
17522116-4	2007	Versican was the predominant CS-containing proteoglycan in the lung and decreased from 19.9 +/- 2.7 arbitrary units at 90 days GA to 6.0 +/- 0.5 arbitrary units at 142 days GA, in close association (P &lt; 0.05) with the reduction in tissue volumes (from 66.0 +/- 4.6 to 25.3 +/- 1.5% at 142 days); similar reductions occurred for both chondroitin-6-sulfate and chondroitin-4-sulfate CS side chains.	Chondroitin Sulfates	362-383	versican core protein	Ovis aries	0-8
17522116-4	2007	Versican was the predominant CS-containing proteoglycan in the lung and decreased from 19.9 +/- 2.7 arbitrary units at 90 days GA to 6.0 +/- 0.5 arbitrary units at 142 days GA, in close association (P &lt; 0.05) with the reduction in tissue volumes (from 66.0 +/- 4.6 to 25.3 +/- 1.5% at 142 days); similar reductions occurred for both chondroitin-6-sulfate and chondroitin-4-sulfate CS side chains.	Chondroitin Sulfates	384-386	versican core protein	Ovis aries	0-8
17470431-4	2007	Our data indicate that this interaction is mediated largely through the binding of glycosaminoglycans (specifically chondroitin 6-sulfate) of aggrecan to binding sites in the thrombospondin type 1 motif and spacer domains of ADAMTS-4 to form a complex with an improved binding affinity for TIMP-3 over free ADAMTS-4.	Chondroitin Sulfates	116-137	TIMP metallopeptidase inhibitor 3	Homo sapiens	290-296
17470431-4	2007	Our data indicate that this interaction is mediated largely through the binding of glycosaminoglycans (specifically chondroitin 6-sulfate) of aggrecan to binding sites in the thrombospondin type 1 motif and spacer domains of ADAMTS-4 to form a complex with an improved binding affinity for TIMP-3 over free ADAMTS-4.	Chondroitin Sulfates	116-137	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	307-315
17500059-5	2007	In situ hybridization for the expression of N-acetylgalac-tosamine-4-sulfate 6-O-sulfotransferase in the postnatal mouse brain, which is involved in the biosynthesis of CS/DS-E, showed a widespread expression of the transcript in the developing brain except at postnatal day 7, where strong expression was observed in the external granule cell layer in the cerebellum.	Chondroitin Sulfates	169-171	carbohydrate sulfotransferase 15	Mus musculus	44-97
17605605-7	2007	Expressions of inducible nitric oxide synthase, cyclooxygenase-2, and microsomal prostaglandin E synthase 1 mRNA were abrogated by GLN-CS and IL-1-GLN-CS treatments.	Chondroitin Sulfates	135-137	prostaglandin-endoperoxide synthase 2	Bos taurus	48-64
17605605-7	2007	Expressions of inducible nitric oxide synthase, cyclooxygenase-2, and microsomal prostaglandin E synthase 1 mRNA were abrogated by GLN-CS and IL-1-GLN-CS treatments.	Chondroitin Sulfates	135-137	prostaglandin E synthase	Bos taurus	70-107
17605605-10	2007	Transcripts of TIMP-3 were increased by IL-1-GLN-CS treatment, compared with IL-1 treatment.	Chondroitin Sulfates	49-51	TIMP metallopeptidase inhibitor 3	Bos taurus	15-21
17605605-10	2007	Transcripts of TIMP-3 were increased by IL-1-GLN-CS treatment, compared with IL-1 treatment.	Chondroitin Sulfates	49-51	interleukin 1 beta	Homo sapiens	40-44
17605605-12	2007	CONCLUSIONS AND CLINICAL RELEVANCE: Treatment with GLN and CS consistently downregulated mRNA expression for inflammatory mediators and matrix degrading enzymes while increasing TIMP-3 transcripts.	Chondroitin Sulfates	59-61	TIMP metallopeptidase inhibitor 3	Bos taurus	178-184
17498992-1	2007	Mucopolysaccharidosis IVA (MPS IVA) is an autosomal recessive disorder caused by deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), required for degradation of keratan sulfate and chondroitin-6-sulfate.	Chondroitin Sulfates	194-215	galactosamine (N-acetyl)-6-sulfate sulfatase	Mus musculus	138-143
17253960-2	2007	These results prompted us to evaluate the effects of co-expression of the recently cloned CSS3 (chondroitin sulfate synthase-3) with ChPF, because ChSy-1 and CSS3 have similar properties, i.e. they possess GalNAcT-II (N-acetylgalactosaminyltransferase-II) and GlcAT-II (glucuronyltransferase-II) activities responsible for the elongation of CS (chondroitin sulfate) chains but cannot polymerize chondroitin chains by themselves.	Chondroitin Sulfates	90-92	chondroitin sulfate synthase 3	Homo sapiens	96-126
17426030-3	2007	Three different mechanisms to interfere with cathepsin-catalyzed collagen degradation are discussed: 1) inhibition of the formation of the cathepsin K/C4-S complex, 2) inhibition of the attachment of C4-S to collagen, and 3) masking of the collagenase cleavage sites in collagen.	Chondroitin Sulfates	151-155	cathepsin K	Homo sapiens	139-150
17426030-5	2007	The main inhibitory effect on collagen degradation is due to the impeding effect on the active cathepsin K/C4-S complex.	Chondroitin Sulfates	107-111	cathepsin K	Homo sapiens	95-106
17426030-6	2007	Essential structural elements in the inhibitor molecules are negative charges which compete with the sulfate groups of C4-S in the cathepsin K/C4-S complex.	Chondroitin Sulfates	119-123	cathepsin K	Homo sapiens	131-142
17426030-6	2007	Essential structural elements in the inhibitor molecules are negative charges which compete with the sulfate groups of C4-S in the cathepsin K/C4-S complex.	Chondroitin Sulfates	143-147	cathepsin K	Homo sapiens	131-142
17426030-8	2007	Longer negatively charged polymers (e.g. polyglutamates, oligonucleotides) tend to inhibit all three mechanisms, whereas shorter ones preferentially affect the cathepsin K/C4-S complex.	Chondroitin Sulfates	172-176	cathepsin K	Homo sapiens	160-171
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Chondroitin Sulfates	28-30	chondroitin sulfate proteoglycan 4	Homo sapiens	91-95
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Chondroitin Sulfates	28-30	chondroitin sulfate proteoglycan 4	Homo sapiens	97-130
17635118-6	2007	TSG-6-mediated HC transfer involves two sequential transesterification processes, where HCs are transferred from the CS (chondroitin sulfate) of IalphaI first on to TSG-6 and then on to HA.	Chondroitin Sulfates	117-119	TNF alpha induced protein 6	Homo sapiens	0-5
17635118-6	2007	TSG-6-mediated HC transfer involves two sequential transesterification processes, where HCs are transferred from the CS (chondroitin sulfate) of IalphaI first on to TSG-6 and then on to HA.	Chondroitin Sulfates	117-119	TNF alpha induced protein 6	Homo sapiens	165-170
17635118-6	2007	TSG-6-mediated HC transfer involves two sequential transesterification processes, where HCs are transferred from the CS (chondroitin sulfate) of IalphaI first on to TSG-6 and then on to HA.	Chondroitin Sulfates	121-140	TNF alpha induced protein 6	Homo sapiens	0-5
17635118-6	2007	TSG-6-mediated HC transfer involves two sequential transesterification processes, where HCs are transferred from the CS (chondroitin sulfate) of IalphaI first on to TSG-6 and then on to HA.	Chondroitin Sulfates	121-140	TNF alpha induced protein 6	Homo sapiens	165-170
17549291-1	2007	The Ca(2+)-dependence of protein C activation by thrombin in complex with thrombomodulin (TM) containing chondroitin sulfate (CS) exhibits saturation at approximately 0.5-1 mM Ca(2+), but with TM lacking CS, it has a distinct optimum at approximately 0.1 mM Ca(2+).	Chondroitin Sulfates	105-124	coagulation factor II, thrombin	Homo sapiens	49-57
17549291-1	2007	The Ca(2+)-dependence of protein C activation by thrombin in complex with thrombomodulin (TM) containing chondroitin sulfate (CS) exhibits saturation at approximately 0.5-1 mM Ca(2+), but with TM lacking CS, it has a distinct optimum at approximately 0.1 mM Ca(2+).	Chondroitin Sulfates	105-124	thrombomodulin	Homo sapiens	74-88
17549291-1	2007	The Ca(2+)-dependence of protein C activation by thrombin in complex with thrombomodulin (TM) containing chondroitin sulfate (CS) exhibits saturation at approximately 0.5-1 mM Ca(2+), but with TM lacking CS, it has a distinct optimum at approximately 0.1 mM Ca(2+).	Chondroitin Sulfates	126-128	coagulation factor II, thrombin	Homo sapiens	49-57
17549291-1	2007	The Ca(2+)-dependence of protein C activation by thrombin in complex with thrombomodulin (TM) containing chondroitin sulfate (CS) exhibits saturation at approximately 0.5-1 mM Ca(2+), but with TM lacking CS, it has a distinct optimum at approximately 0.1 mM Ca(2+).	Chondroitin Sulfates	126-128	thrombomodulin	Homo sapiens	74-88
17549291-1	2007	The Ca(2+)-dependence of protein C activation by thrombin in complex with thrombomodulin (TM) containing chondroitin sulfate (CS) exhibits saturation at approximately 0.5-1 mM Ca(2+), but with TM lacking CS, it has a distinct optimum at approximately 0.1 mM Ca(2+).	Chondroitin Sulfates	204-206	coagulation factor II, thrombin	Homo sapiens	49-57
17549291-1	2007	The Ca(2+)-dependence of protein C activation by thrombin in complex with thrombomodulin (TM) containing chondroitin sulfate (CS) exhibits saturation at approximately 0.5-1 mM Ca(2+), but with TM lacking CS, it has a distinct optimum at approximately 0.1 mM Ca(2+).	Chondroitin Sulfates	204-206	thrombomodulin	Homo sapiens	74-88
17549291-2	2007	Since the substrate protein C has multiple Ca(2+)-binding sites, and the cofactor TM also interacts with Ca(2+), the basis for differences in Ca(2+) effect on protein C activation by thrombin in complex with TM containing or lacking CS is not known.	Chondroitin Sulfates	233-235	coagulation factor II, thrombin	Homo sapiens	183-191
17384412-0	2007	The sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte elastase and cathepsin G.	Chondroitin Sulfates	22-41	elastase, neutrophil expressed	Homo sapiens	153-171
17384412-0	2007	The sulfate groups of chondroitin sulfate- and heparan sulfate-containing proteoglycans in neutrophil plasma membranes are novel binding sites for human leukocyte elastase and cathepsin G.	Chondroitin Sulfates	22-41	cathepsin G	Homo sapiens	176-187
17384412-6	2007	The sulfate groups of heparan sulfate- and chondroitin sulfate-containing proteoglycans are the PMN binding sites for HLE and CG since binding of HLE and CG to PMN was inhibited by incubating PMN with 1) trypsin, chondroitinase ABC, and heparitinases, but not other glycanases, and 2) purified chondroitin sulfates, heparan sulfate, and other sulfated molecules, but not with non-sulfated glycans.	Chondroitin Sulfates	43-62	cathepsin G	Homo sapiens	126-128
17384412-6	2007	The sulfate groups of heparan sulfate- and chondroitin sulfate-containing proteoglycans are the PMN binding sites for HLE and CG since binding of HLE and CG to PMN was inhibited by incubating PMN with 1) trypsin, chondroitinase ABC, and heparitinases, but not other glycanases, and 2) purified chondroitin sulfates, heparan sulfate, and other sulfated molecules, but not with non-sulfated glycans.	Chondroitin Sulfates	43-62	cathepsin G	Homo sapiens	154-156
17384412-6	2007	The sulfate groups of heparan sulfate- and chondroitin sulfate-containing proteoglycans are the PMN binding sites for HLE and CG since binding of HLE and CG to PMN was inhibited by incubating PMN with 1) trypsin, chondroitinase ABC, and heparitinases, but not other glycanases, and 2) purified chondroitin sulfates, heparan sulfate, and other sulfated molecules, but not with non-sulfated glycans.	Chondroitin Sulfates	294-314	cathepsin G	Homo sapiens	126-128
17384412-6	2007	The sulfate groups of heparan sulfate- and chondroitin sulfate-containing proteoglycans are the PMN binding sites for HLE and CG since binding of HLE and CG to PMN was inhibited by incubating PMN with 1) trypsin, chondroitinase ABC, and heparitinases, but not other glycanases, and 2) purified chondroitin sulfates, heparan sulfate, and other sulfated molecules, but not with non-sulfated glycans.	Chondroitin Sulfates	294-314	cathepsin G	Homo sapiens	154-156
17384412-7	2007	Thus, heparan sulfate- and chondroitin sulfate-containing proteoglycans are low affinity, high volume PMN surface binding sites for HLE and CG, which are well suited to bind high concentrations of active serine proteinases released from degranulating PMN.	Chondroitin Sulfates	27-46	cathepsin G	Homo sapiens	140-142
17217338-6	2007	Activation of pro-MMP-2 by suboptimal concentrations of MT3-MMP is also significantly enhanced in the presence of excess C4S (chondroitin 4-sulfate), whereas C6S (chondroitin 6-sulfate) or low-molecular-mass hyaluronan was ineffective.	Chondroitin Sulfates	121-124	matrix metallopeptidase 2	Homo sapiens	18-23
17217338-6	2007	Activation of pro-MMP-2 by suboptimal concentrations of MT3-MMP is also significantly enhanced in the presence of excess C4S (chondroitin 4-sulfate), whereas C6S (chondroitin 6-sulfate) or low-molecular-mass hyaluronan was ineffective.	Chondroitin Sulfates	121-124	matrix metallopeptidase 16	Homo sapiens	56-63
17217338-6	2007	Activation of pro-MMP-2 by suboptimal concentrations of MT3-MMP is also significantly enhanced in the presence of excess C4S (chondroitin 4-sulfate), whereas C6S (chondroitin 6-sulfate) or low-molecular-mass hyaluronan was ineffective.	Chondroitin Sulfates	126-147	matrix metallopeptidase 2	Homo sapiens	18-23
17217338-6	2007	Activation of pro-MMP-2 by suboptimal concentrations of MT3-MMP is also significantly enhanced in the presence of excess C4S (chondroitin 4-sulfate), whereas C6S (chondroitin 6-sulfate) or low-molecular-mass hyaluronan was ineffective.	Chondroitin Sulfates	126-147	matrix metallopeptidase 16	Homo sapiens	56-63
17217338-6	2007	Activation of pro-MMP-2 by suboptimal concentrations of MT3-MMP is also significantly enhanced in the presence of excess C4S (chondroitin 4-sulfate), whereas C6S (chondroitin 6-sulfate) or low-molecular-mass hyaluronan was ineffective.	Chondroitin Sulfates	158-161	matrix metallopeptidase 2	Homo sapiens	18-23
17217338-7	2007	Affinity chromatography studies using CS isolated from aggrecan indicate that the catalytic domain of MT3-MMP and the C-terminal domain of MMP-2 directly bind to the GAG.	Chondroitin Sulfates	38-40	matrix metallopeptidase 16	Homo sapiens	102-109
17217338-7	2007	Affinity chromatography studies using CS isolated from aggrecan indicate that the catalytic domain of MT3-MMP and the C-terminal domain of MMP-2 directly bind to the GAG.	Chondroitin Sulfates	38-40	matrix metallopeptidase 2	Homo sapiens	139-144
17217338-8	2007	Thus the direct binding of pro-MMP-2 with CS through the C-domain would present the catalytic domain of pro-MMP-2 to MT3-MMP, which facilitates the generation of the active form of MMP-2.	Chondroitin Sulfates	42-44	matrix metallopeptidase 2	Homo sapiens	31-36
17217338-8	2007	Thus the direct binding of pro-MMP-2 with CS through the C-domain would present the catalytic domain of pro-MMP-2 to MT3-MMP, which facilitates the generation of the active form of MMP-2.	Chondroitin Sulfates	42-44	matrix metallopeptidase 2	Homo sapiens	108-113
17217338-8	2007	Thus the direct binding of pro-MMP-2 with CS through the C-domain would present the catalytic domain of pro-MMP-2 to MT3-MMP, which facilitates the generation of the active form of MMP-2.	Chondroitin Sulfates	42-44	matrix metallopeptidase 16	Homo sapiens	117-124
17217338-8	2007	Thus the direct binding of pro-MMP-2 with CS through the C-domain would present the catalytic domain of pro-MMP-2 to MT3-MMP, which facilitates the generation of the active form of MMP-2.	Chondroitin Sulfates	42-44	matrix metallopeptidase 2	Homo sapiens	108-113
17253960-2	2007	These results prompted us to evaluate the effects of co-expression of the recently cloned CSS3 (chondroitin sulfate synthase-3) with ChPF, because ChSy-1 and CSS3 have similar properties, i.e. they possess GalNAcT-II (N-acetylgalactosaminyltransferase-II) and GlcAT-II (glucuronyltransferase-II) activities responsible for the elongation of CS (chondroitin sulfate) chains but cannot polymerize chondroitin chains by themselves.	Chondroitin Sulfates	90-92	chondroitin polymerizing factor	Homo sapiens	133-137
17253960-2	2007	These results prompted us to evaluate the effects of co-expression of the recently cloned CSS3 (chondroitin sulfate synthase-3) with ChPF, because ChSy-1 and CSS3 have similar properties, i.e. they possess GalNAcT-II (N-acetylgalactosaminyltransferase-II) and GlcAT-II (glucuronyltransferase-II) activities responsible for the elongation of CS (chondroitin sulfate) chains but cannot polymerize chondroitin chains by themselves.	Chondroitin Sulfates	96-115	chondroitin sulfate synthase 3	Homo sapiens	90-94
17253960-2	2007	These results prompted us to evaluate the effects of co-expression of the recently cloned CSS3 (chondroitin sulfate synthase-3) with ChPF, because ChSy-1 and CSS3 have similar properties, i.e. they possess GalNAcT-II (N-acetylgalactosaminyltransferase-II) and GlcAT-II (glucuronyltransferase-II) activities responsible for the elongation of CS (chondroitin sulfate) chains but cannot polymerize chondroitin chains by themselves.	Chondroitin Sulfates	96-115	chondroitin polymerizing factor	Homo sapiens	133-137
17253960-7	2007	Moreover, overexpression of CSS3 increased the amount of CS in HeLa cells, while the RNA interference of CSS3 resulted in a reduction in the amount of CS in the cells.	Chondroitin Sulfates	57-59	chondroitin sulfate synthase 3	Homo sapiens	28-32
17463159-3	2007	The effect of chondroitin sulfate A (CSA) on MMPs in type II collagen-induced experimental arthritis was studied.	Chondroitin Sulfates	14-35	matrix metallopeptidase 2	Homo sapiens	45-49
17324393-4	2007	Since the enzyme arylsulfatase B (ASB) catalyzes hydrolysis of the sulfate ester of N-acetylgalactosamine 4-sulfate, a component of dermatan sulfate and chondroitin A sulfate, determination of ASB activity in human airway epithelial cells, corrected and uncorrected for CFTR, was undertaken.	Chondroitin Sulfates	153-174	arylsulfatase B	Homo sapiens	17-32
17324393-4	2007	Since the enzyme arylsulfatase B (ASB) catalyzes hydrolysis of the sulfate ester of N-acetylgalactosamine 4-sulfate, a component of dermatan sulfate and chondroitin A sulfate, determination of ASB activity in human airway epithelial cells, corrected and uncorrected for CFTR, was undertaken.	Chondroitin Sulfates	153-174	arylsulfatase B	Homo sapiens	34-37
17379830-8	2007	Pretreatment of the cells with chondroitinase ABC greatly decreased the amount of the PN-1 associated to TM at the cell surface demonstrating the involvement of the TM chondroitin-sulfate chain in the formation of complexes.	Chondroitin Sulfates	168-187	serpin family E member 2	Homo sapiens	86-90
17169545-0	2007	Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors.	Chondroitin Sulfates	12-31	fibroblast growth factor 2	Mus musculus	89-94
17169545-0	2007	Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors.	Chondroitin Sulfates	12-31	fibroblast growth factor 2	Mus musculus	89-92
17227754-11	2007	The results from this study provide insight into the differences and similarities various residues play in the biological roles of the HS-2OST and CS-2OST enzymes.	Chondroitin Sulfates	147-149	Heparan sulfate 2-O-sulfotransferase	Drosophila melanogaster	135-142
17154173-7	2007	We found that P-selectin reacted primarily with cell surface chondroitin sulfate (CS) proteoglycans, which were abundantly and stably expressed on the surface of the 4T1 cell line.	Chondroitin Sulfates	61-80	selectin, platelet	Mus musculus	14-24
17154173-7	2007	We found that P-selectin reacted primarily with cell surface chondroitin sulfate (CS) proteoglycans, which were abundantly and stably expressed on the surface of the 4T1 cell line.	Chondroitin Sulfates	82-84	selectin, platelet	Mus musculus	14-24
17154173-10	2007	In addition, the data suggest that surface CS GAG chains were involved in P-selectin mediated adhesion of the 4T1 cells to murine platelets and human umbilical vein endothelial cells.	Chondroitin Sulfates	43-45	selectin, platelet	Mus musculus	74-84
17154173-11	2007	The data suggest that CS GAGs are also the major P-selectin-reactive ligands on the surface of human MDA-MET cells.	Chondroitin Sulfates	22-24	selectin, platelet	Mus musculus	49-59
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Chondroitin Sulfates	28-30	matrix metallopeptidase 16	Homo sapiens	161-168
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Chondroitin Sulfates	32-51	chondroitin sulfate proteoglycan 4	Homo sapiens	91-95
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Chondroitin Sulfates	32-51	chondroitin sulfate proteoglycan 4	Homo sapiens	97-130
17217338-1	2007	We previously reported that CS (chondroitin sulfate) GAG (glycosaminoglycan), expressed on MCSP (melanoma-specific CS proteoglycan), is important for regulating MT3-MMP [membrane-type 3 MMP (matrix metalloproteinase)]-mediated human melanoma invasion and gelatinolytic activity in vitro.	Chondroitin Sulfates	32-51	matrix metallopeptidase 16	Homo sapiens	161-168
17217338-2	2007	In the present study, we sought to determine if CS can directly enhance MT3-MMP-mediated activation of pro-MMP-2.	Chondroitin Sulfates	48-50	matrix metallopeptidase 16	Homo sapiens	72-79
17217338-2	2007	In the present study, we sought to determine if CS can directly enhance MT3-MMP-mediated activation of pro-MMP-2.	Chondroitin Sulfates	48-50	matrix metallopeptidase 2	Homo sapiens	107-112
17217338-4	2007	When melanoma cells were treated with betaDX (p-nitro-beta-D-xylopyranoside) to inhibit coupling of CS on the core protein, both active form and proform of MMP-2 were no longer co-immunoprecipitated with either MCSP or MT3-MMP, suggesting a model in which CS directly binds to MMP-2 and presents the gelatinase to MT3-MMP to be activated.	Chondroitin Sulfates	100-102	matrix metallopeptidase 2	Homo sapiens	156-161
17255106-4	2007	These results suggest that cleavage at preferred sites in the chondroitin sulfate-rich region is mediated by ADAMTS-4 or an aggrecanase other than ADAMTS-5.	Chondroitin Sulfates	62-81	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4	Mus musculus	109-117
17255106-4	2007	These results suggest that cleavage at preferred sites in the chondroitin sulfate-rich region is mediated by ADAMTS-4 or an aggrecanase other than ADAMTS-5.	Chondroitin Sulfates	62-81	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)	Mus musculus	147-155
17123943-4	2007	In the current study, we report a novel method to purify pB1 from boar seminal plasma by chondroitin sulfate B-affinity chromatography and reverse-phase-high performance liquid chromatography.	Chondroitin Sulfates	89-108	polybromo 1	Bos taurus	57-60
17276897-8	2007	When compared to bovine cartilage extract, collagen, and chondroitin sulfate, shark cartilage induced significantly higher levels of TNFalpha.	Chondroitin Sulfates	57-76	tumor necrosis factor	Bos taurus	133-141
17352757-1	2007	We describe synthetic extracellular matrix (sECM) hydrogel films composed of co-crosslinked thiolated derivatives of chondroitin 6-sulfate (CS) and heparin (HP) for controlled-release delivery of basic fibroblast growth factor (bFGF) to full-thickness wounds in genetically diabetic (db/db) mice.	Chondroitin Sulfates	117-138	fibroblast growth factor 2	Mus musculus	196-226
17352757-1	2007	We describe synthetic extracellular matrix (sECM) hydrogel films composed of co-crosslinked thiolated derivatives of chondroitin 6-sulfate (CS) and heparin (HP) for controlled-release delivery of basic fibroblast growth factor (bFGF) to full-thickness wounds in genetically diabetic (db/db) mice.	Chondroitin Sulfates	117-138	fibroblast growth factor 2	Mus musculus	228-232
17352757-1	2007	We describe synthetic extracellular matrix (sECM) hydrogel films composed of co-crosslinked thiolated derivatives of chondroitin 6-sulfate (CS) and heparin (HP) for controlled-release delivery of basic fibroblast growth factor (bFGF) to full-thickness wounds in genetically diabetic (db/db) mice.	Chondroitin Sulfates	140-142	fibroblast growth factor 2	Mus musculus	196-226
17189265-0	2007	Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans.	Chondroitin Sulfates	109-128	xylosyltransferase 2	Homo sapiens	6-27
17189265-3	2007	Here, we report the enzymatic activity of XT-II and provide evidence that XT-II initiates the biosynthesis of both heparan sulfate and chondroitin sulfate GAGs.	Chondroitin Sulfates	135-154	xylosyltransferase 2	Homo sapiens	42-47
17189265-3	2007	Here, we report the enzymatic activity of XT-II and provide evidence that XT-II initiates the biosynthesis of both heparan sulfate and chondroitin sulfate GAGs.	Chondroitin Sulfates	135-154	xylosyltransferase 2	Homo sapiens	74-79
17189265-5	2007	GAG disaccharide analysis revealed that XT-I- and XT-II-transfected pgsA-745 cells produced similar amounts of chondroitin sulfate and heparan sulfate.	Chondroitin Sulfates	111-130	xylosyltransferase 1	Homo sapiens	40-44
17189265-5	2007	GAG disaccharide analysis revealed that XT-I- and XT-II-transfected pgsA-745 cells produced similar amounts of chondroitin sulfate and heparan sulfate.	Chondroitin Sulfates	111-130	xylosyltransferase 2	Homo sapiens	50-55
17189265-11	2007	This is the first report on the enzyme activity of XT-II and its involvement in chondroitin sulfate and heparan sulfate biosynthesis.	Chondroitin Sulfates	80-99	xylosyltransferase 2	Homo sapiens	51-56
17189266-7	2007	Transfection of this cell line with a murine Xylt2 minigene results in the production of recombinant chondroitin sulfate-modified biglycan core protein and restoration of fibroblast growth factor binding to cell surface-associated heparan sulfate.	Chondroitin Sulfates	101-120	xylosyltransferase II	Mus musculus	45-50
17379830-8	2007	Pretreatment of the cells with chondroitinase ABC greatly decreased the amount of the PN-1 associated to TM at the cell surface demonstrating the involvement of the TM chondroitin-sulfate chain in the formation of complexes.	Chondroitin Sulfates	168-187	thrombomodulin	Homo sapiens	165-167
17145755-12	2007	Direct binding assays with the 315-HARE ectodomain revealed high affinity HA binding, and lower binding affinities for CS-C, CS-D, and CS-E.	Chondroitin Sulfates	119-121	stabilin 2	Homo sapiens	35-39
17145755-12	2007	Direct binding assays with the 315-HARE ectodomain revealed high affinity HA binding, and lower binding affinities for CS-C, CS-D, and CS-E.	Chondroitin Sulfates	125-127	stabilin 2	Homo sapiens	35-39
17317573-5	2007	We also demonstrated that heparan sulfate and chondroitin sulfate interact in a sulfation-dependent manner with various axon guidance proteins, including slit2, netrin1, ephrinA1, ephrinA5, and semaphorin5B.	Chondroitin Sulfates	46-65	slit guidance ligand 2	Homo sapiens	154-159
17317573-5	2007	We also demonstrated that heparan sulfate and chondroitin sulfate interact in a sulfation-dependent manner with various axon guidance proteins, including slit2, netrin1, ephrinA1, ephrinA5, and semaphorin5B.	Chondroitin Sulfates	46-65	netrin 1	Homo sapiens	161-168
17317573-5	2007	We also demonstrated that heparan sulfate and chondroitin sulfate interact in a sulfation-dependent manner with various axon guidance proteins, including slit2, netrin1, ephrinA1, ephrinA5, and semaphorin5B.	Chondroitin Sulfates	46-65	ephrin A1	Homo sapiens	170-178
17317573-5	2007	We also demonstrated that heparan sulfate and chondroitin sulfate interact in a sulfation-dependent manner with various axon guidance proteins, including slit2, netrin1, ephrinA1, ephrinA5, and semaphorin5B.	Chondroitin Sulfates	46-65	ephrin A5	Homo sapiens	180-188
17317573-5	2007	We also demonstrated that heparan sulfate and chondroitin sulfate interact in a sulfation-dependent manner with various axon guidance proteins, including slit2, netrin1, ephrinA1, ephrinA5, and semaphorin5B.	Chondroitin Sulfates	46-65	semaphorin 5B	Homo sapiens	194-206
16899336-9	2007	The effect of terazosin on GAGs and MMP-2 may contribute in the molecular mechanisms of terazosin-induced apoptosis because HS and CS have a proapoptotic effect, whereas DS and MMP-2 are antiapoptotic.	Chondroitin Sulfates	131-133	matrix metallopeptidase 2	Rattus norvegicus	36-41
16996709-8	2007	We also characterized the release of a model drug, diclofenac sodium (DS) and a model protein, bovine serum albumin (BSA), from CS-EX and CS-EX-IPN.	Chondroitin Sulfates	128-130	albumin	Homo sapiens	102-115
17096385-0	2007	Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B.	Chondroitin Sulfates	152-171	C-X-C motif chemokine ligand 1	Homo sapiens	49-57
17096385-9	2007	These phenomena proved to be dependent on the co-receptor role of sulfated glycosaminoglycans (sGAG) and the activation of p38 MAPK, since they were abrogated either by preincubation with soluble chondroitin-4 sulfate or p38 MAPK inhibitors.	Chondroitin Sulfates	196-217	mitogen-activated protein kinase 14	Homo sapiens	123-126
17285619-8	2007	In transgenic mice that vary in expression of human PF4 on their platelets, antigenic complexes form between PF4 and endogenous chondroitin sulfate.	Chondroitin Sulfates	128-147	platelet factor 4	Homo sapiens	52-55
17145758-0	2007	Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage.	Chondroitin Sulfates	0-19	chondroitin sulfate synthase 1	Mus musculus	20-55
17145758-0	2007	Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage.	Chondroitin Sulfates	81-100	chondroitin sulfate synthase 1	Mus musculus	20-55
17145758-3	2007	Here, we demonstrate that chondroitin sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) plays a critical role in CS biosynthesis in cartilage.	Chondroitin Sulfates	83-85	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	26-81
17145758-10	2007	These observations indicate that CSGalNAcT-1 overexpression increases the number of CS chains attached to aggrecan core protein.	Chondroitin Sulfates	33-35	aggrecan	Mus musculus	106-127
17285619-8	2007	In transgenic mice that vary in expression of human PF4 on their platelets, antigenic complexes form between PF4 and endogenous chondroitin sulfate.	Chondroitin Sulfates	128-147	platelet factor 4	Homo sapiens	109-112
16908205-11	2007	A decrease in either GAG sulfation or CS content diminished bACs" response to Wnt3a (approximately 40% and 37% of control, respectively).	Chondroitin Sulfates	38-40	solute carrier family 27 member 5	Homo sapiens	60-65
16908205-11	2007	A decrease in either GAG sulfation or CS content diminished bACs" response to Wnt3a (approximately 40% and 37% of control, respectively).	Chondroitin Sulfates	38-40	Wnt family member 3A	Homo sapiens	78-83
16908205-12	2007	Similar effects on the response to Wnt3a via beta-catenin were observed for cultured hACs with undersulfation of GAGs (16% of control) and decreased CS content (20% of control).	Chondroitin Sulfates	149-151	Wnt family member 3A	Homo sapiens	35-40
16908205-12	2007	Similar effects on the response to Wnt3a via beta-catenin were observed for cultured hACs with undersulfation of GAGs (16% of control) and decreased CS content (20% of control).	Chondroitin Sulfates	149-151	catenin beta 1	Homo sapiens	45-57
16970940-4	2007	In the present study, we tested the hypothesis that degradation of chondroitin sulfate proteoglycan by application of chondroitinase at the site of nerve repair can decrease aberrant axonal growth.	Chondroitin Sulfates	67-86	galactosamine (N-acetyl)-6-sulfatase	Rattus norvegicus	118-132
17352757-5	2007	Addition of bFGF to CS films showed partial dose-dependent acceleration of wound repair.	Chondroitin Sulfates	20-22	fibroblast growth factor 2	Mus musculus	12-16
17996099-6	2007	Interestingly, OPG expression and production under basal conditions or vitamin D3 treatment were upregulated by CS and by both CS and GS incubated together.	Chondroitin Sulfates	112-114	TNF receptor superfamily member 11b	Homo sapiens	15-18
17996099-6	2007	Interestingly, OPG expression and production under basal conditions or vitamin D3 treatment were upregulated by CS and by both CS and GS incubated together.	Chondroitin Sulfates	127-129	TNF receptor superfamily member 11b	Homo sapiens	15-18
17996099-7	2007	Under basal conditions, RANKL expression was significantly reduced by CS and by both drugs incubated together.	Chondroitin Sulfates	70-72	TNF superfamily member 11	Homo sapiens	24-29
17996099-9	2007	Importantly, under basal conditions, CS and both compounds combined significantly upregulated the expression ratio of OPG/RANKL.	Chondroitin Sulfates	37-39	TNF receptor superfamily member 11b	Homo sapiens	118-121
17996099-9	2007	Importantly, under basal conditions, CS and both compounds combined significantly upregulated the expression ratio of OPG/RANKL.	Chondroitin Sulfates	37-39	TNF superfamily member 11	Homo sapiens	122-127
17996099-13	2007	Yet CS and both compounds together increase the expression ratio of OPG/RANKL, suggesting a positive effect on OA subchondral bone structural changes.	Chondroitin Sulfates	4-6	TNF receptor superfamily member 11b	Homo sapiens	68-71
17996099-13	2007	Yet CS and both compounds together increase the expression ratio of OPG/RANKL, suggesting a positive effect on OA subchondral bone structural changes.	Chondroitin Sulfates	4-6	TNF superfamily member 11	Homo sapiens	72-77
17176260-1	2007	Pregnancy-associated malaria (PAM) is caused by Plasmodium falciparum-infected erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM-associated clonally variant surface antigens (VSA).	Chondroitin Sulfates	111-133	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	30-33
17176260-1	2007	Pregnancy-associated malaria (PAM) is caused by Plasmodium falciparum-infected erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM-associated clonally variant surface antigens (VSA).	Chondroitin Sulfates	111-133	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	159-162
17176260-1	2007	Pregnancy-associated malaria (PAM) is caused by Plasmodium falciparum-infected erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM-associated clonally variant surface antigens (VSA).	Chondroitin Sulfates	135-138	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	30-33
17176260-1	2007	Pregnancy-associated malaria (PAM) is caused by Plasmodium falciparum-infected erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM-associated clonally variant surface antigens (VSA).	Chondroitin Sulfates	135-138	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	159-162
17176260-3	2007	Here, we report an investigation of the specificity of naturally acquired immunity to PAM, using eight human monoclonal IgG1 antibodies that react exclusively with intact CSA-adhering IEs expressing VSA(PAM).	Chondroitin Sulfates	171-174	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	86-89
17958921-5	2007	Pregnancy malaria is generally associated with the emergence of a distinct subset of parasites expressing a unique PfEMP1 that binds to the host-receptor chondroitin sulfate A (CSA).	Chondroitin Sulfates	154-175	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	177-180
17068111-6	2006	Most highly conserved between EMR2 and CD97 is the fourth EGF domain, which mediates binding to chondroitin sulfate, a ligand specificity shared by both receptors.	Chondroitin Sulfates	96-115	adhesion G protein-coupled receptor E2	Homo sapiens	30-34
17094944-0	2006	Midkine as a molecular target: comparison of effects of chondroitin sulfate E and siRNA.	Chondroitin Sulfates	56-75	midkine	Homo sapiens	0-7
17094944-5	2006	These results indicate the significance of midkine as a molecular target to treat or prevent rheumatoid arthritis and adhesion after surgery, and the utility of chondroitin sulfate E to inhibit midkine in vivo.	Chondroitin Sulfates	161-180	midkine	Homo sapiens	194-201
17040900-0	2006	Chondroitin 4-O-sulfotransferase-1 regulates E disaccharide expression of chondroitin sulfate required for herpes simplex virus infectivity.	Chondroitin Sulfates	74-93	carbohydrate sulfotransferase 11	Mus musculus	0-34
17068111-6	2006	Most highly conserved between EMR2 and CD97 is the fourth EGF domain, which mediates binding to chondroitin sulfate, a ligand specificity shared by both receptors.	Chondroitin Sulfates	96-115	adhesion G protein-coupled receptor E5	Homo sapiens	39-43
16847433-1	2006	Versican is a large chondroitin sulfate proteoglycan produced by several tumor cell types, including malignant melanoma, which exists as four different splice variants.	Chondroitin Sulfates	20-39	versican	Homo sapiens	0-8
16987814-3	2006	We found that glutamate-elicited NMDA receptor currents in cultured hippocampal neurons were reduced by approximately 30% with the application of polysialic acid or polysialylated NCAM but not by the sialic acid monomer, chondroitin sulfate, or non-polysialylated NCAM.	Chondroitin Sulfates	221-240	neural cell adhesion molecule 1	Homo sapiens	180-184
17139379-5	2006	In fact, after oral administration of fucosylated chondroitin sulfate to rats, we observed a dose-dependent increase in the plasma anticoagulant activity, as assessed by assays for activated partial thromboplastin time (aPTT) and thrombin time (TT) (about 3- and 5-fold, respectively) and by anti-IIa activity.	Chondroitin Sulfates	50-69	coagulation factor II	Rattus norvegicus	230-238
16956892-15	2006	To our knowledge, apolipoprotein O is the first chondroitin sulfate chain containing apolipoprotein.	Chondroitin Sulfates	48-67	apolipoprotein O	Homo sapiens	18-34
16621725-1	2006	Pregnancy-associated malaria is characterized by Plasmodium falciparum adherence to chondroitin sulfate A (CSA) in placenta, through a particular variant surface antigen (VSA).	Chondroitin Sulfates	84-105	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	107-110
16954212-6	2006	The majority of rat placental SSP is present in the CSPG form, and only approximately 10% occurs without CS chain substitution.	Chondroitin Sulfates	52-54	trophoblast specific protein alpha	Rattus norvegicus	30-33
16954212-7	2006	Of the total SSP-CSPG in rat placenta, approximately 57% is modified with a single CS chain, and approximately 43% carries two CS chains.	Chondroitin Sulfates	17-19	trophoblast specific protein alpha	Rattus norvegicus	13-16
16954212-10	2006	Furthermore, the rat SSP-CSPG binds P. falciparum IRBCs in a CS chain-dependent manner.	Chondroitin Sulfates	25-27	trophoblast specific protein alpha	Rattus norvegicus	21-24
16901907-4	2006	Neuroglycan C lacking chondroitin sulfate chains was eluted with 0.5 m NaCl as a major fraction from the column.	Chondroitin Sulfates	22-41	chondroitin sulfate proteoglycan 5	Rattus norvegicus	0-13
16901907-6	2006	Among three functional domains of the extracellular part of neuroglycan C, the chondroitin sulfate attachment domain and acidic amino acid cluster box domain showed affinity for midkine, but the epidermal growth factor domain did not.	Chondroitin Sulfates	79-98	chondroitin sulfate proteoglycan 5	Rattus norvegicus	60-73
16901907-6	2006	Among three functional domains of the extracellular part of neuroglycan C, the chondroitin sulfate attachment domain and acidic amino acid cluster box domain showed affinity for midkine, but the epidermal growth factor domain did not.	Chondroitin Sulfates	79-98	midkine	Rattus norvegicus	178-185
17003493-3	2006	However, we discovered that genes associated with differentiation (GDF15 and ATF3) and suppression of proliferation (CDKNa1/p21) were up-regulated in highly invasive uveal melanoma cells forming vasculogenic mimicry patterns, and genes associated with promotion of invasive and metastatic behavior such as CD44, CCNE2 (cyclin E2), THBS1 (thrombospondin 1), and CSPG2 (chondroitin sulfate proteoglycan; versican) were down-regulated.	Chondroitin Sulfates	368-387	growth differentiation factor 15	Homo sapiens	67-72
17003493-3	2006	However, we discovered that genes associated with differentiation (GDF15 and ATF3) and suppression of proliferation (CDKNa1/p21) were up-regulated in highly invasive uveal melanoma cells forming vasculogenic mimicry patterns, and genes associated with promotion of invasive and metastatic behavior such as CD44, CCNE2 (cyclin E2), THBS1 (thrombospondin 1), and CSPG2 (chondroitin sulfate proteoglycan; versican) were down-regulated.	Chondroitin Sulfates	368-387	H3 histone pseudogene 16	Homo sapiens	124-127
16936295-7	2006	CONCLUSION: These results reflect changes in ECM metabolism in progressive ovarian cancer, which cause an increase in serum CS epitopes and HA.	Chondroitin Sulfates	124-126	multimerin 1	Homo sapiens	45-48
16945513-0	2006	Effects of covalently attached chondroitin sulfate on aggrecan cleavage by ADAMTS-4 and MMP-13.	Chondroitin Sulfates	31-50	A disintegrin and metalloproteinase with thrombospondin motifs 4	Cricetulus griseus	75-83
16945513-2	2006	ADAMTS-4 and MMPs cleave aggrecan more efficiently within the chondroitin sulfate (CS)-rich region than the interglobular domain (IGD).	Chondroitin Sulfates	62-81	A disintegrin and metalloproteinase with thrombospondin motifs 4	Cricetulus griseus	0-8
16945513-2	2006	ADAMTS-4 and MMPs cleave aggrecan more efficiently within the chondroitin sulfate (CS)-rich region than the interglobular domain (IGD).	Chondroitin Sulfates	83-85	A disintegrin and metalloproteinase with thrombospondin motifs 4	Cricetulus griseus	0-8
16945513-6	2006	This result suggests that KS in the IGD may compete with CS for ADAMTS-4 (p68) binding.	Chondroitin Sulfates	57-59	A disintegrin and metalloproteinase with thrombospondin motifs 4	Cricetulus griseus	64-72
16945513-9	2006	When digested with the ADAMTS-4 (p68), each of these preparations exhibited reduced CS-2 domain cleavage compared to CS-substituted CHO-K1 cell-derived aggrecan.	Chondroitin Sulfates	84-86	A disintegrin and metalloproteinase with thrombospondin motifs 4	Cricetulus griseus	23-31
16945513-9	2006	When digested with the ADAMTS-4 (p68), each of these preparations exhibited reduced CS-2 domain cleavage compared to CS-substituted CHO-K1 cell-derived aggrecan.	Chondroitin Sulfates	117-119	A disintegrin and metalloproteinase with thrombospondin motifs 4	Cricetulus griseus	23-31
16945513-11	2006	ADAMTS-4 (p40) readily cleaved both rbAggs within the IGD, but cleaved poorly within the CS-2 domain, indicating little CS dependence.	Chondroitin Sulfates	89-91	A disintegrin and metalloproteinase with thrombospondin motifs 4	Cricetulus griseus	0-8
16945513-12	2006	MMP-13, in contrast, cleaved the CS region and the IGD of both CS-substituted and CS-deficient rbAgg equally well.	Chondroitin Sulfates	33-35	LOW QUALITY PROTEIN: collagenase 3	Cricetulus griseus	0-6
16945513-12	2006	MMP-13, in contrast, cleaved the CS region and the IGD of both CS-substituted and CS-deficient rbAgg equally well.	Chondroitin Sulfates	63-65	LOW QUALITY PROTEIN: collagenase 3	Cricetulus griseus	0-6
16945513-13	2006	These data indicate that covalently bound CS enhances ADAMTS-4-mediated cleavage within the CS-rich region.	Chondroitin Sulfates	42-44	A disintegrin and metalloproteinase with thrombospondin motifs 4	Cricetulus griseus	54-62
16945513-13	2006	These data indicate that covalently bound CS enhances ADAMTS-4-mediated cleavage within the CS-rich region.	Chondroitin Sulfates	92-94	A disintegrin and metalloproteinase with thrombospondin motifs 4	Cricetulus griseus	54-62
16945513-14	2006	MMP-13 also cleaves preferentially within the CS-region, but by an apparently CS-independent mechanism.	Chondroitin Sulfates	46-48	LOW QUALITY PROTEIN: collagenase 3	Cricetulus griseus	0-6
16945513-14	2006	MMP-13 also cleaves preferentially within the CS-region, but by an apparently CS-independent mechanism.	Chondroitin Sulfates	78-80	LOW QUALITY PROTEIN: collagenase 3	Cricetulus griseus	0-6
16779785-1	2006	Chondroitin sulfate (CS) is a linear heteropolysaccharide consisting of repeating disaccharide units of glucuronic acid and galactosamine, which is commonly sulfated at C-4 and/or C-6 of galactosamine.	Chondroitin Sulfates	0-19	complement C4A (Rodgers blood group)	Homo sapiens	169-172
16951369-4	2006	The only difference between secreted proteoglycan and secreted glycoprotein CSF-1 isoforms is the presence (proteoglycan) or absence (glycoprotein) of an 18-kDa chondroitin sulfate glycosaminoglycan.	Chondroitin Sulfates	161-180	colony stimulating factor 1 (macrophage)	Mus musculus	76-81
16951369-6	2006	Taken together, we have identified central roles for the cell surface CSF-1 and the chondroitin sulfate chain on secreted proteoglycan CSF-1 during renal inflammation.	Chondroitin Sulfates	84-103	colony stimulating factor 1 (macrophage)	Mus musculus	135-140
16146580-3	2006	A gene of special interest was that for neuroglycan C (NGC), a neural tissue-specific transmembrane chondroitin sulphate proteoglycan.	Chondroitin Sulfates	100-120	chondroitin sulfate proteoglycan 5	Rattus norvegicus	40-53
16624819-0	2006	Chondroitin sulfate intake inhibits the IgE-mediated allergic response by down-regulating Th2 responses in mice.	Chondroitin Sulfates	0-19	heart and neural crest derivatives expressed 2	Mus musculus	90-93
16624819-1	2006	Chondroitin sulfate (CS) was administered orally to BALB/c mice immunized intraperitoneally with ovalbumin (OVA) and/or dinitrophenylated OVA.	Chondroitin Sulfates	0-19	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	97-106
16821268-7	2006	RESULTS: The GLN and CS combination abrogated IL-1-induced gene expression of iNOS, COX-2, mPGEs1, and NF-kB at all timepoints.	Chondroitin Sulfates	21-23	nitric oxide synthase 2	Bos taurus	78-82
16821268-7	2006	RESULTS: The GLN and CS combination abrogated IL-1-induced gene expression of iNOS, COX-2, mPGEs1, and NF-kB at all timepoints.	Chondroitin Sulfates	21-23	prostaglandin-endoperoxide synthase 2	Bos taurus	84-89
16821268-7	2006	RESULTS: The GLN and CS combination abrogated IL-1-induced gene expression of iNOS, COX-2, mPGEs1, and NF-kB at all timepoints.	Chondroitin Sulfates	21-23	prostaglandin E synthase	Mus musculus	91-97
16821268-11	2006	CONCLUSION: GLN and CS in combination suppress synthesis and expression of genes encoding inflammatory mediators and proteolytic enzymes while upregulating TIMP-3.	Chondroitin Sulfates	20-22	TIMP metallopeptidase inhibitor 3	Bos taurus	156-162
16648631-1	2006	Versican/PG-M is a large chondroitin sulfate proteoglycan of the extracellular matrix with a common domain structure to aggrecan and is present in cartilage at low levels.	Chondroitin Sulfates	25-44	versican	Mus musculus	0-8
16648631-6	2006	Chondroitin sulfate chains of versican digested with chondroitinase ABC contained 71% nonsulfated and 28% 4-sulfated unsaturated disaccharides, whereas those of aggrecan contained 25% nonsulfated and 70% 4-sulfated.	Chondroitin Sulfates	0-19	versican	Mus musculus	30-38
16771479-0	2006	Discovery of a TNF-alpha antagonist using chondroitin sulfate microarrays.	Chondroitin Sulfates	42-61	tumor necrosis factor	Homo sapiens	15-24
16771479-2	2006	Using the microarrays, we identify a novel interaction between CS and TNF-alpha, a proinflammatory cytokine involved in rheumatoid arthritis, Crohn"s disease, and psoriasis.	Chondroitin Sulfates	63-65	tumor necrosis factor	Homo sapiens	70-79
16768462-6	2006	Similarly, complex formation was prevented if the chondroitin sulfate chain was cleaved, releasing bikunin but maintaining the HC1 and HC2 PGP cross-links.	Chondroitin Sulfates	50-69	alpha-1-microglobulin/bikunin precursor	Homo sapiens	99-106
16768462-6	2006	Similarly, complex formation was prevented if the chondroitin sulfate chain was cleaved, releasing bikunin but maintaining the HC1 and HC2 PGP cross-links.	Chondroitin Sulfates	50-69	CYCS pseudogene 39	Homo sapiens	127-130
16768462-6	2006	Similarly, complex formation was prevented if the chondroitin sulfate chain was cleaved, releasing bikunin but maintaining the HC1 and HC2 PGP cross-links.	Chondroitin Sulfates	50-69	CYCS pseudogene 38	Homo sapiens	135-138
16768462-6	2006	Similarly, complex formation was prevented if the chondroitin sulfate chain was cleaved, releasing bikunin but maintaining the HC1 and HC2 PGP cross-links.	Chondroitin Sulfates	50-69	phosphoglycolate phosphatase	Homo sapiens	139-142
16768462-11	2006	Initially, a cation-independent interaction between TSG-6 and the chondroitin sulfate chain is formed at site 1.	Chondroitin Sulfates	66-85	TNF alpha induced protein 6	Homo sapiens	52-57
16882545-11	2006	When chondroitin sulfate and albumin were used as the microneedle base, the serum EPO levels vs. time profiles showed almost the same pattern.	Chondroitin Sulfates	5-24	erythropoietin	Mus musculus	82-85
16705694-7	2006	Purified perlecan from the hypertrophic/lower proliferative zone had larger chondroitin sulfate chains and a different composition of CS and HS disaccharides than the perlecan isolated from the resting zone.	Chondroitin Sulfates	76-95	heparan sulfate proteoglycan 2	Bos taurus	9-17
16778156-12	2006	In conclusion, we could show that key enzymes for CS, DS, and HS synthesis, especially XT-I, are useful markers for the developmental stages of chondrogenic differentiation.	Chondroitin Sulfates	50-52	xylosyltransferase 1	Homo sapiens	87-91
16828054-5	2006	GAGs from different structure/origin (heparan sulfate, dermatan sulfate, and chondroitin sulfate) exert similar activity on OPG binding.	Chondroitin Sulfates	77-96	TNF receptor superfamily member 11b	Homo sapiens	124-127
16581272-0	2006	Mixtures of glucosamine and chondroitin sulfate reverse fibronectin fragment mediated damage to cartilage more effectively than either agent alone.	Chondroitin Sulfates	28-47	fibronectin 1	Bos taurus	56-67
16624819-8	2006	The splenocytes from the mice fed with CS produced less interleukin (IL)-5, IL-10, and IL-13 than those from the control group.	Chondroitin Sulfates	39-41	interleukin 5	Mus musculus	56-74
16624819-8	2006	The splenocytes from the mice fed with CS produced less interleukin (IL)-5, IL-10, and IL-13 than those from the control group.	Chondroitin Sulfates	39-41	interleukin 10	Mus musculus	76-81
16624819-8	2006	The splenocytes from the mice fed with CS produced less interleukin (IL)-5, IL-10, and IL-13 than those from the control group.	Chondroitin Sulfates	39-41	interleukin 13	Mus musculus	87-92
16624819-9	2006	In contrast, the production of interferon-gamma and IL-2 by the splenocytes of mice fed with CS was not significantly different from those in the control mice.	Chondroitin Sulfates	93-95	interferon gamma	Mus musculus	31-47
16624819-9	2006	In contrast, the production of interferon-gamma and IL-2 by the splenocytes of mice fed with CS was not significantly different from those in the control mice.	Chondroitin Sulfates	93-95	interleukin 2	Mus musculus	52-56
16624819-11	2006	Furthermore, we showed that the percentages of CD4(+) cells, CD8(+) cells, and CD4(+)CD25(+) cells in the splenocytes of mice fed with CS are significantly higher than those of the control.	Chondroitin Sulfates	135-137	CD4 antigen	Mus musculus	47-50
16624819-11	2006	Furthermore, we showed that the percentages of CD4(+) cells, CD8(+) cells, and CD4(+)CD25(+) cells in the splenocytes of mice fed with CS are significantly higher than those of the control.	Chondroitin Sulfates	135-137	CD4 antigen	Mus musculus	79-82
16624819-12	2006	These findings suggest that oral intake of CS inhibits the specific IgE production and antigen-induced anaphylactic response by up-regulating regulatory T-cell differentiation, followed by down-regulating the Th2 response.	Chondroitin Sulfates	43-45	heart and neural crest derivatives expressed 2	Mus musculus	209-212
16679517-8	2006	The structure of the CS chains was shown to vary between the CS1 and CS2 domains, particularly in the adult, with variation occurring in chain length and the sulfation of the non-reducing terminal N-acetyl galactosamine residue.	Chondroitin Sulfates	21-23	chorionic somatomammotropin hormone 1	Homo sapiens	61-64
16679517-8	2006	The structure of the CS chains was shown to vary between the CS1 and CS2 domains, particularly in the adult, with variation occurring in chain length and the sulfation of the non-reducing terminal N-acetyl galactosamine residue.	Chondroitin Sulfates	21-23	chorionic somatomammotropin hormone 2	Homo sapiens	69-72
16679517-9	2006	CS chains in the adult CS2 domain were shorter than those in the CS1 domain and possessed disulfated terminal residues in addition to monosulfated residues.	Chondroitin Sulfates	0-2	chorionic somatomammotropin hormone 2	Homo sapiens	23-26
16779785-1	2006	Chondroitin sulfate (CS) is a linear heteropolysaccharide consisting of repeating disaccharide units of glucuronic acid and galactosamine, which is commonly sulfated at C-4 and/or C-6 of galactosamine.	Chondroitin Sulfates	0-19	complement C6	Homo sapiens	180-183
16779785-1	2006	Chondroitin sulfate (CS) is a linear heteropolysaccharide consisting of repeating disaccharide units of glucuronic acid and galactosamine, which is commonly sulfated at C-4 and/or C-6 of galactosamine.	Chondroitin Sulfates	21-23	complement C4A (Rodgers blood group)	Homo sapiens	169-172
16779785-1	2006	Chondroitin sulfate (CS) is a linear heteropolysaccharide consisting of repeating disaccharide units of glucuronic acid and galactosamine, which is commonly sulfated at C-4 and/or C-6 of galactosamine.	Chondroitin Sulfates	21-23	complement C6	Homo sapiens	180-183
16407841-1	2006	The human high molecular weight-melanoma associated antigen (HMW-MAA) is a membrane-bound chondroitin sulfate proteoglycan that is variably expressed in a high percentage of melanoma cell lines and tumors.	Chondroitin Sulfates	90-109	chondroitin sulfate proteoglycan 4	Homo sapiens	10-59
16513268-1	2006	Ptprz is a receptor-type protein tyrosine phosphatase predominantly expressed in the brain as a chondroitin sulfate proteoglycan.	Chondroitin Sulfates	96-115	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	0-5
16407841-1	2006	The human high molecular weight-melanoma associated antigen (HMW-MAA) is a membrane-bound chondroitin sulfate proteoglycan that is variably expressed in a high percentage of melanoma cell lines and tumors.	Chondroitin Sulfates	90-109	chondroitin sulfate proteoglycan 4	Homo sapiens	61-68
16421105-0	2006	A chondroitin sulfate chain attached to the bone dentin matrix protein 1 NH2-terminal fragment.	Chondroitin Sulfates	2-21	dentin matrix acidic phosphoprotein 1	Homo sapiens	49-72
16430888-1	2006	Plasmodium falciparum parasites that sequester in the placenta bind to the molecule chondroitin sulfate A (CSA).	Chondroitin Sulfates	84-105	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	107-110
16431924-1	2006	We have detected versican, a member of the large chondroitin sulfate proteoglycans, and its degraded C-terminal G3 fragments in human plasma and observed that the versican G3 domain promoted blood coagulation.	Chondroitin Sulfates	49-68	versican	Homo sapiens	17-25
16955703-5	2006	One important, developmentally regulated chondroitin sulfate proteoglycan is DSD-1-PG/phosphacan, a glial derived proteoglycan which represents a splice variant of the receptor protein tyrosine phosphatase (RPTP)-beta (also known as PTP-zeta).	Chondroitin Sulfates	41-60	protein tyrosine phosphatase receptor type Z1	Homo sapiens	86-96
16507336-5	2006	All three ADAMTS-5 isoforms bound to sulfated GAGs (heparin and chondroitin sulfate (CS)).	Chondroitin Sulfates	64-83	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	10-18
16507336-5	2006	All three ADAMTS-5 isoforms bound to sulfated GAGs (heparin and chondroitin sulfate (CS)).	Chondroitin Sulfates	85-87	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	10-18
16407455-4	2006	For example, NEP1-40 is a synthetic peptide that promotes axonal regeneration by blocking Nogo-66/NgR interaction and chondroitinase ABC (ChABC), which degrades CS, thereby also promoting axon regrowth.	Chondroitin Sulfates	161-163	EMG1 N1-specific pseudouridine methyltransferase	Homo sapiens	13-17
16453269-2	2006	Pregnant women are infected by Plasmodium falciparum with novel antigenic phenotypes that adhere to chondroitin sulfate A (CSA) and other receptors in the placenta.	Chondroitin Sulfates	100-121	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	123-126
16503173-6	2006	TGFbeta and/or soluble CS was added to human articular chondrocytes (HACs) and activation of p38 and extracellular signal related kinase (ERK)1/2 was determined by immunoblot analysis.	Chondroitin Sulfates	23-25	mitogen-activated protein kinase 1	Homo sapiens	93-96
16503173-6	2006	TGFbeta and/or soluble CS was added to human articular chondrocytes (HACs) and activation of p38 and extracellular signal related kinase (ERK)1/2 was determined by immunoblot analysis.	Chondroitin Sulfates	23-25	mitogen-activated protein kinase 3	Homo sapiens	101-145
16503173-10	2006	Most prominent, the silencing of p38 stress signal by CS was superimposable to that of TGFbeta.	Chondroitin Sulfates	54-56	mitogen-activated protein kinase 1	Homo sapiens	33-36
16503173-10	2006	Most prominent, the silencing of p38 stress signal by CS was superimposable to that of TGFbeta.	Chondroitin Sulfates	54-56	transforming growth factor beta 1	Homo sapiens	87-94
16503173-13	2006	Finally, suppression of LPS induced MMP-13 mRNA levels resulted with CS.	Chondroitin Sulfates	69-71	matrix metallopeptidase 13	Homo sapiens	36-42
16503173-14	2006	CONCLUSION: Soluble CS modulates signaling events in chondrocytes concurrent with MMP-13 down regulation.	Chondroitin Sulfates	20-22	matrix metallopeptidase 13	Homo sapiens	82-88
16503173-15	2006	The effects observed suggest a feedback signaling mechanism cross talking with TGFbeta-signal pathways and may serve an explanation, on the cellular level, for the beneficial effects found in clinical studies with pharmacologic application of CS.	Chondroitin Sulfates	243-245	transforming growth factor beta 1	Homo sapiens	79-86
16373347-7	2006	Interestingly, both CS polysaccharides and commercial preparations of dermatan sulfate CS-B and an E-type of highly sulfated CS promoted the fibroblast growth factor-2-mediated proliferation of neural stem/progenitor cells.	Chondroitin Sulfates	20-22	fibroblast growth factor 2	Rattus norvegicus	141-167
16427204-6	2006	In addition, cleavage of rbAgg by ADAMTS-4 revealed that the p68 form of ADAMTS-4 preferentially cleaves within the CS-2 domain, whereas the p40 form only effectively cleaves within the interglobular domain (IGD).	Chondroitin Sulfates	116-118	DNA polymerase delta 3, accessory subunit	Bos taurus	61-64
16427204-6	2006	In addition, cleavage of rbAgg by ADAMTS-4 revealed that the p68 form of ADAMTS-4 preferentially cleaves within the CS-2 domain, whereas the p40 form only effectively cleaves within the interglobular domain (IGD).	Chondroitin Sulfates	116-118	ADAM metallopeptidase with thrombospondin type 1 motif 4	Bos taurus	73-81
16427204-7	2006	MMP-13 cleaved rbAgg within the IGD, but cleaved more rapidly at a site within the CS domains, suggesting a role in C-terminal processing of aggrecan.	Chondroitin Sulfates	83-85	matrix metallopeptidase 13	Bos taurus	0-6
16187070-1	2006	To analyze the growth-related changes in extracellular matrix components in temporomandibular joint (TMJ) discs, the expression and localization of the core protein of a large chondroitin sulphate proteoglycan, versican, in rat TMJ discs during postnatal development (2-32 weeks) were examined using Western blot analysis, real-time quantitative PCR and immunohistochemistry.	Chondroitin Sulfates	176-196	versican	Rattus norvegicus	211-219
16373346-0	2006	The binding of chondroitin sulfate to pleiotrophin/heparin-binding growth-associated molecule is regulated by chain length and oversulfated structures.	Chondroitin Sulfates	15-34	pleiotrophin	Homo sapiens	38-50
16373346-0	2006	The binding of chondroitin sulfate to pleiotrophin/heparin-binding growth-associated molecule is regulated by chain length and oversulfated structures.	Chondroitin Sulfates	15-34	pleiotrophin	Homo sapiens	51-93
16373346-1	2006	Pleiotrophin is an 18-kDa heparin-binding growth factor, which uses chondroitin sulfate (CS) proteoglycan, PTPzeta as a receptor.	Chondroitin Sulfates	68-87	pleiotrophin	Homo sapiens	0-12
16373346-1	2006	Pleiotrophin is an 18-kDa heparin-binding growth factor, which uses chondroitin sulfate (CS) proteoglycan, PTPzeta as a receptor.	Chondroitin Sulfates	89-91	pleiotrophin	Homo sapiens	0-12
16373346-2	2006	It has been suggested that the D-type structure (GlcA(2S)beta1-3GalNAc(6S)) in CS contributes to the high affinity binding between PTPzeta and pleiotrophin.	Chondroitin Sulfates	79-81	pleiotrophin	Homo sapiens	143-155
16373346-5	2006	The &gt; or =18-mer CS fractions showed significant binding to pleiotrophin, and the longer fractions had stronger affinity for pleiotrophin than the shorter ones.	Chondroitin Sulfates	20-22	pleiotrophin	Homo sapiens	63-75
16373346-6	2006	The approximately 46-mer CS fraction bound to densely immobilized pleiotrophin with high affinity (K(D) = approximately 30 nM), and the binding reactions fitted the bivalent analyte model.	Chondroitin Sulfates	25-27	pleiotrophin	Homo sapiens	66-78
16373346-10	2006	These results suggest that the binding of pleiotrophin to CS is regulated by multivalency with CS approximately 20 mer as a unit and by the amounts of oversulfated structures.	Chondroitin Sulfates	58-60	pleiotrophin	Homo sapiens	42-54
16373346-10	2006	These results suggest that the binding of pleiotrophin to CS is regulated by multivalency with CS approximately 20 mer as a unit and by the amounts of oversulfated structures.	Chondroitin Sulfates	95-97	pleiotrophin	Homo sapiens	42-54
16385080-8	2006	These results indicate a central role for versican and its constituent chondroitin sulfate chains in controlling cell phenotype, elastogenesis, and intimal structure.	Chondroitin Sulfates	71-90	versican	Rattus norvegicus	42-50
16274691-1	2006	Chondroitin sulfate A (CSA) present in the placental intervillous blood spaces has been described as the main receptor involved in the massive sequestration of Plasmodium falciparum parasitized erythrocytes to the placenta.	Chondroitin Sulfates	0-21	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	23-26
16548693-11	2006	Cells on CS-containing scaffolds in the presence of dexamethasone showed the highest ALP production.	Chondroitin Sulfates	9-11	alkaline phosphatase, placental	Homo sapiens	85-88
16257955-2	2006	Versican/PG-M, a large chondroitin sulfate proteoglycan, is one of the major molecules expressed in the extracellular matrix during condensation.	Chondroitin Sulfates	23-42	versican	Homo sapiens	0-8
16257955-10	2006	These results suggest that versican/PG-M is involved in positively regulating the formation of the mesenchymal matrix and the onset of chondrocyte differentiation through the attached chondroitin sulfate chains.	Chondroitin Sulfates	184-203	versican	Homo sapiens	27-35
16425147-4	2006	The chondroitin sulphate chains are present in two adjacent regions of the aggrecan core protein, termed the CS1 and CS2 domains.	Chondroitin Sulfates	4-24	chorionic somatomammotropin hormone 1	Homo sapiens	109-112
16425147-5	2006	In the human, the region of the aggrecan gene encoding the CS1 domain exhibits size polymorphism, which can result in variation in the degree of chondroitin sulphate substitution of aggrecan in different individuals.	Chondroitin Sulfates	145-165	chorionic somatomammotropin hormone 1	Homo sapiens	59-62
16210339-0	2006	Developmental and functional significance of the CSF-1 proteoglycan chondroitin sulfate chain.	Chondroitin Sulfates	68-87	colony stimulating factor 1 (macrophage)	Mus musculus	49-54
16955703-5	2006	One important, developmentally regulated chondroitin sulfate proteoglycan is DSD-1-PG/phosphacan, a glial derived proteoglycan which represents a splice variant of the receptor protein tyrosine phosphatase (RPTP)-beta (also known as PTP-zeta).	Chondroitin Sulfates	41-60	protein tyrosine phosphatase receptor type Z1	Homo sapiens	207-217
16955703-5	2006	One important, developmentally regulated chondroitin sulfate proteoglycan is DSD-1-PG/phosphacan, a glial derived proteoglycan which represents a splice variant of the receptor protein tyrosine phosphatase (RPTP)-beta (also known as PTP-zeta).	Chondroitin Sulfates	41-60	protein tyrosine phosphatase receptor type Z1	Homo sapiens	233-241
16385517-7	2006	RESULTS: The glycosaminoglycan chondroitin sulfate, but not fibronectin or collagens, bound and released MCP-1 in a time-dependent manner.	Chondroitin Sulfates	31-50	C-C motif chemokine ligand 2	Homo sapiens	105-110
16385517-8	2006	MCP-1 that was released from chondroitin sulfate induced the differentiation of interleukin-4 (IL-4)-producing T cells in a dose-dependent manner.	Chondroitin Sulfates	29-48	C-C motif chemokine ligand 2	Homo sapiens	0-5
16385517-8	2006	MCP-1 that was released from chondroitin sulfate induced the differentiation of interleukin-4 (IL-4)-producing T cells in a dose-dependent manner.	Chondroitin Sulfates	29-48	interleukin 4	Homo sapiens	80-93
16385517-8	2006	MCP-1 that was released from chondroitin sulfate induced the differentiation of interleukin-4 (IL-4)-producing T cells in a dose-dependent manner.	Chondroitin Sulfates	29-48	interleukin 4	Homo sapiens	95-99
16099038-7	2006	We demonstrate that BDNF encourages neurite growth into the scaffolds, and reduces further the minimal inflammatory response agarose gels generate in vivo as evidenced by quantitative analysis of the extent of NF-160 kDA positive neurons and axons, GFAP positive reactive astrocytes, and CS-56 positive chondroitin sulfate proteoglycan at the interface of the scaffold and host spinal cord.	Chondroitin Sulfates	303-322	brain-derived neurotrophic factor	Rattus norvegicus	20-24
16845893-1	2006	Versican, a chondroitin sulfate proteoglycan, is one of the main components of the extracellular matrix, which provides a loose and hydrated matrix during key events in development and disease.	Chondroitin Sulfates	12-31	versican	Homo sapiens	0-8
16275145-0	2006	Purified human chondroitin-4-sulfate reduced MMP/TIMP imbalance induced by iron plus ascorbate in human fibroblast cultures.	Chondroitin Sulfates	15-36	TIMP metallopeptidase inhibitor 1	Homo sapiens	49-53
16275145-3	2006	Since previous studies showed that commercial hyaluronan and chondroitin-4-sulphate are able to limit lipid peroxidation during oxidative stress, we investigated the antioxidant capacity of purified human plasma chondroitin-4-sulfate in reducing MMP and TIMP imbalance in a model of ROS-induced oxidative injury in fibroblast cultures.	Chondroitin Sulfates	212-233	TIMP metallopeptidase inhibitor 1	Homo sapiens	254-258
16850582-7	2006	After activation, NK cells release the following proteolytic enzymes: perforin, serine esterase (granzymes A and B) chondroitin sulphate, phospholipases and other lytic molecules, and destroy malignantly transformed cells by necrotic process.	Chondroitin Sulfates	116-136	granzyme A	Homo sapiens	97-114
16289010-1	2005	A simple, rapid, and reproducible microtiter-based chondroitinase (CSase) assay is reported here, based on the competition of chondroitin sulfate (CS) with immobilized hyaluronan (HA) for the binding of TSG-6 protein, the product of TNF-inducible gene 6.	Chondroitin Sulfates	126-145	TNF alpha induced protein 6	Homo sapiens	203-208
16223867-6	2006	HS and chondroitin sulfate Prg expression was determined by immunohistochemistry using three monoclonal antibodies.	Chondroitin Sulfates	7-26	serglycin	Mus musculus	27-30
16324103-2	2005	During normal development of the mouse neocortex, thalamic axons immunoreactive for the neural cell adhesion molecule L1 rarely invaded the cortical plate and ran centered in the subplate which is immunoreactive for neurocan, a brain-specific chondroitin sulfate proteoglycan.	Chondroitin Sulfates	243-262	L1 cell adhesion molecule	Mus musculus	88-120
16303928-9	2005	CONCLUSIONS: Opticin binds to heparin, HS, chondroitin 4-sulfate, and dermatan sulfate, the binding affinity being dependent on sulfation pattern and oligosaccharide chain length.	Chondroitin Sulfates	43-64	opticin	Homo sapiens	13-20
16120610-0	2005	Demonstration of the pleiotrophin-binding oligosaccharide sequences isolated from chondroitin sulfate/dermatan sulfate hybrid chains of embryonic pig brains.	Chondroitin Sulfates	82-101	pleiotrophin	Mus musculus	21-33
16120610-2	2005	CS/DS chains isolated from embryonic pig brains (E-CS/DS) promote the outgrowth of neurites in embryonic mouse hippocampal neurons in culture by interacting with pleiotrophin (PTN), a heparin-binding growth factor.	Chondroitin Sulfates	0-2	pleiotrophin	Mus musculus	162-174
16120610-2	2005	CS/DS chains isolated from embryonic pig brains (E-CS/DS) promote the outgrowth of neurites in embryonic mouse hippocampal neurons in culture by interacting with pleiotrophin (PTN), a heparin-binding growth factor.	Chondroitin Sulfates	0-2	pleiotrophin	Mus musculus	176-179
16120610-9	2005	Notably, not only heparan sulfate but also CS/DS hybrid chain structures of mammalian brains contain a high degree of microheterogeneity with a cluster of oversulfated disaccharides and appear to play roles in regulating the functions of PTN.	Chondroitin Sulfates	43-45	pleiotrophin	Homo sapiens	238-241
17115009-5	2006	Most often they seem to be proteoglycans containing heparan sulfate and chondroitin sulfate, which can also be a part of the multimolecular receptor complexes binding midkine.	Chondroitin Sulfates	72-91	midkine	Homo sapiens	167-174
16287098-2	2005	GALNS is required to degrade glycosaminoglycans, keratan sulfate (KS), and chondroitin-6-sulfate.	Chondroitin Sulfates	75-96	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	0-5
16317389-7	2005	Data from experiments with Chinese hamster ovary cells with altered glycosaminoglycan expression indicated that heparan sulfate and chondroitin sulfate (glycosaminoglycans on the syndecan-1 ectodomain) participated in bacterial interactions with mammalian cells.	Chondroitin Sulfates	132-151	syndecan-1	Cricetulus griseus	179-189
16288042-3	2005	WiDr cells bound to the laminin A5G27 peptide via the heparin-like and chondroitin sulfate B glycosaminoglycan side chains of CD44.	Chondroitin Sulfates	71-90	CD44 molecule (Indian blood group)	Homo sapiens	126-130
16334942-6	2005	RESULTS: Upregulated MMP-3, MMP-13, and Agg-1 transcripts at 24 hours were repressed by the GLN and CS combination by at least approximately 6-fold.	Chondroitin Sulfates	100-102	stromelysin-1	Bos taurus	21-26
16334942-6	2005	RESULTS: Upregulated MMP-3, MMP-13, and Agg-1 transcripts at 24 hours were repressed by the GLN and CS combination by at least approximately 6-fold.	Chondroitin Sulfates	100-102	matrix metallopeptidase 13	Bos taurus	28-34
16334942-7	2005	Glucosamine was effective in suppressing IL-1-induced mRNA expression of MMP-13, Agg-1, and Agg-2, whereas CS was effective in decreasing IL-1-induced MMP-13 transcript at 24 hours.	Chondroitin Sulfates	107-109	matrix metallopeptidase 13	Bos taurus	151-157
16225657-6	2005	Finally, TSP adhesion of both sickle RBCs and dehydrated normal RBCs was inhibited by the anionic polysaccharides, chondroitin sulphate A and high molecular weight dextran sulphate, but not by competitors of CD47-, band 3-, or RBC phosphatidylserine-mediated adhesion.	Chondroitin Sulfates	115-137	CTR9 homolog, Paf1/RNA polymerase II complex component	Mus musculus	9-12
16175577-8	2005	Furthermore, the amount of pleiotrophin, a heparin-binding growth factor, in the cultured cerebellar slices was remarkably diminished after treatment with chondroitinase ABC or D unit-rich chondroitin sulfate.	Chondroitin Sulfates	189-208	pleiotrophin	Homo sapiens	27-39
16175577-9	2005	With the previous findings that pleiotrophin binds to D unit-rich chondroitin sulfate, we suggest that the D-type structure is important for the signaling of pleiotrophin, which plays roles in Purkinje cell-Bergmann glia interaction, and that the structural changes of chondroitin sulfate regulate this signaling pathway.	Chondroitin Sulfates	66-85	pleiotrophin	Homo sapiens	32-44
16175577-9	2005	With the previous findings that pleiotrophin binds to D unit-rich chondroitin sulfate, we suggest that the D-type structure is important for the signaling of pleiotrophin, which plays roles in Purkinje cell-Bergmann glia interaction, and that the structural changes of chondroitin sulfate regulate this signaling pathway.	Chondroitin Sulfates	66-85	pleiotrophin	Homo sapiens	158-170
16175577-9	2005	With the previous findings that pleiotrophin binds to D unit-rich chondroitin sulfate, we suggest that the D-type structure is important for the signaling of pleiotrophin, which plays roles in Purkinje cell-Bergmann glia interaction, and that the structural changes of chondroitin sulfate regulate this signaling pathway.	Chondroitin Sulfates	269-288	pleiotrophin	Homo sapiens	32-44
16175577-9	2005	With the previous findings that pleiotrophin binds to D unit-rich chondroitin sulfate, we suggest that the D-type structure is important for the signaling of pleiotrophin, which plays roles in Purkinje cell-Bergmann glia interaction, and that the structural changes of chondroitin sulfate regulate this signaling pathway.	Chondroitin Sulfates	269-288	pleiotrophin	Homo sapiens	158-170
16289010-1	2005	A simple, rapid, and reproducible microtiter-based chondroitinase (CSase) assay is reported here, based on the competition of chondroitin sulfate (CS) with immobilized hyaluronan (HA) for the binding of TSG-6 protein, the product of TNF-inducible gene 6.	Chondroitin Sulfates	67-69	TNF alpha induced protein 6	Homo sapiens	203-208
16289010-6	2005	Using the HA-binding domain of aggrecan for a comparison, we determined that the interaction between TSG-6 and chondroitin sulfate is uniquely suited for this CSase assay.	Chondroitin Sulfates	111-130	TNF alpha induced protein 6	Homo sapiens	101-106
16181411-1	2005	The second Ig module (IgII) of the neural cell adhesion molecule (NCAM) is known to bind to the first Ig module (IgI) of NCAM (so-called homophilic binding) and to interact with heparan sulfate and chondroitin sulfate glycoconjugates.	Chondroitin Sulfates	198-217	neural cell adhesion molecule 1	Homo sapiens	35-64
16136474-2	2005	The recombinant protein binds specifically to chondroitin sulfate A (CSA) and inhibits CSA binding by placental infected erythrocytes (IEs).	Chondroitin Sulfates	46-67	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	69-72
15958243-7	2005	Finally, when these hydrogels were implanted into subcutaneous pockets in Balb/c mice, neovascularization increased dramatically with HA and CS hydrogels that contained both bFGF and crosslinked heparin.	Chondroitin Sulfates	141-143	fibroblast growth factor 2	Mus musculus	174-178
16181411-1	2005	The second Ig module (IgII) of the neural cell adhesion molecule (NCAM) is known to bind to the first Ig module (IgI) of NCAM (so-called homophilic binding) and to interact with heparan sulfate and chondroitin sulfate glycoconjugates.	Chondroitin Sulfates	198-217	neural cell adhesion molecule 1	Homo sapiens	66-70
16181411-1	2005	The second Ig module (IgII) of the neural cell adhesion molecule (NCAM) is known to bind to the first Ig module (IgI) of NCAM (so-called homophilic binding) and to interact with heparan sulfate and chondroitin sulfate glycoconjugates.	Chondroitin Sulfates	198-217	neural cell adhesion molecule 1	Homo sapiens	121-125
16181411-5	2005	In contrast, treatment with heparinase III or chondroitinase ABC abrogates NCAM-mediated neurite outgrowth in CGNs emphasizing the importance of the presence of heparan/chondroitin sulfates for proper NCAM function.	Chondroitin Sulfates	169-189	neural cell adhesion molecule 1	Homo sapiens	75-79
16181411-7	2005	These observations indicate that neuronal differentiation induced by homophilic NCAM interaction is modulated by interactions with heparan/chondroitin sulfates.	Chondroitin Sulfates	139-159	neural cell adhesion molecule 1	Homo sapiens	80-84
21794254-0	2005	[Effect of chondroitin sulfate and hyaluronic acid (500-730 kDa) on synthesis of stromelysin (MMP-3) and MMP-1 in human chondrocyte cultures].	Chondroitin Sulfates	11-30	matrix metallopeptidase 1	Homo sapiens	105-110
21794254-5	2005	OBJECTIVES: To analyze the effect of CS and HA (500-730 kDa) on MMP-3 and MMP-1 synthesis induced by interleukin-1beta (IL-1beta) in OA chondrocytes.	Chondroitin Sulfates	37-39	matrix metallopeptidase 3	Homo sapiens	64-69
21794254-5	2005	OBJECTIVES: To analyze the effect of CS and HA (500-730 kDa) on MMP-3 and MMP-1 synthesis induced by interleukin-1beta (IL-1beta) in OA chondrocytes.	Chondroitin Sulfates	37-39	matrix metallopeptidase 1	Homo sapiens	74-79
21794254-5	2005	OBJECTIVES: To analyze the effect of CS and HA (500-730 kDa) on MMP-3 and MMP-1 synthesis induced by interleukin-1beta (IL-1beta) in OA chondrocytes.	Chondroitin Sulfates	37-39	interleukin 1 beta	Homo sapiens	101-118
21794254-5	2005	OBJECTIVES: To analyze the effect of CS and HA (500-730 kDa) on MMP-3 and MMP-1 synthesis induced by interleukin-1beta (IL-1beta) in OA chondrocytes.	Chondroitin Sulfates	37-39	interleukin 1 beta	Homo sapiens	120-128
21794254-8	2005	RESULTS: CS and HA inhibited IL-1beta-induced MMP-3 synthesis, without significantly modifying MMP-1.	Chondroitin Sulfates	9-11	interleukin 1 beta	Homo sapiens	29-37
21794254-8	2005	RESULTS: CS and HA inhibited IL-1beta-induced MMP-3 synthesis, without significantly modifying MMP-1.	Chondroitin Sulfates	9-11	matrix metallopeptidase 3	Homo sapiens	46-51
21794254-9	2005	CS and HA reduced levels of MMP-3 expression at all the studied concentrations, with no statistically significant differences among these concentrations.	Chondroitin Sulfates	0-2	matrix metallopeptidase 3	Homo sapiens	28-33
21794254-10	2005	CONCLUSIONS: The results of this study show for the first time that CS inhibits MMP-3 synthesis in OA cartilage.	Chondroitin Sulfates	68-70	matrix metallopeptidase 3	Homo sapiens	80-85
16113309-1	2005	Antibodies targeting variant antigens on the surfaces of chondroitin sulfate A (CSA)-binding malaria-infected erythrocytes have been linked to protection against the complications of malaria in pregnancy.	Chondroitin Sulfates	57-78	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	80-83
16027159-3	2005	Furthermore, in mutant gro2C cells that express CS but not heparan sulfate, CS-E showed unusually high anti-herpes virus activity with IC(50) values of &lt;1 ng/ml.	Chondroitin Sulfates	48-50	cystathionase (cystathionine gamma-lyase)	Mus musculus	76-80
16027159-7	2005	Likewise, the gro2C-specific CS chains interfered with the binding of viral gC to these cells and were found to contain a considerable proportion (13%) of the E-disaccharide unit, suggesting that this unit is an essential component of the CS receptor for herpes simplex virus on gro2C cells and that the antiviral activity of CS-E was due to interference with the binding of viral gC to a CS-E-like receptor on the cell surface.	Chondroitin Sulfates	29-31	cystathionase (cystathionine gamma-lyase)	Mus musculus	326-330
16027159-7	2005	Likewise, the gro2C-specific CS chains interfered with the binding of viral gC to these cells and were found to contain a considerable proportion (13%) of the E-disaccharide unit, suggesting that this unit is an essential component of the CS receptor for herpes simplex virus on gro2C cells and that the antiviral activity of CS-E was due to interference with the binding of viral gC to a CS-E-like receptor on the cell surface.	Chondroitin Sulfates	29-31	cystathionase (cystathionine gamma-lyase)	Mus musculus	389-393
16024005-2	2005	We have previously cloned N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST), which transfers sulfate from 3"-phosphoadenosine 5"-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units.	Chondroitin Sulfates	230-251	carbohydrate sulfotransferase 15	Homo sapiens	80-92
16024005-2	2005	We have previously cloned N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST), which transfers sulfate from 3"-phosphoadenosine 5"-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units.	Chondroitin Sulfates	230-251	complement C6	Homo sapiens	176-179
16024005-3	2005	To investigate the function of chondroitin sulfate E, the development of specific inhibitors of GalNAc4S-6ST is important.	Chondroitin Sulfates	31-50	carbohydrate sulfotransferase 15	Homo sapiens	96-108
16143959-1	2005	Resonance Rayleigh scattering (RRS) spectra resulting from interaction between chondroitin sulfate A (CSA) and crystal violet (CV) have been investigated and applied to the determination of CSA.	Chondroitin Sulfates	79-100	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	102-105
16143959-1	2005	Resonance Rayleigh scattering (RRS) spectra resulting from interaction between chondroitin sulfate A (CSA) and crystal violet (CV) have been investigated and applied to the determination of CSA.	Chondroitin Sulfates	79-100	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	190-193
16079159-8	2005	These results show that chondroitin 4-O-sulfation by C4st1 is required for proper chondroitin sulfate localization, modulation of distinct signaling pathways and cartilage growth plate morphogenesis.	Chondroitin Sulfates	82-101	carbohydrate sulfotransferase 11	Homo sapiens	53-58
16002044-4	2005	Here, we identify serine 180 in human CD44H as the site of chondroitin sulfate addition and show that lack of chondroitin sulfate addition at this site enhances hyaluronan binding by CD44.	Chondroitin Sulfates	59-78	CD44 molecule (Indian blood group)	Homo sapiens	38-42
16193383-5	2005	IL-2 polymer microspheres (IL-2 MS) were produced via the complex coacervation of gelatin and chondroitin sulfate in the presence of IL-2.	Chondroitin Sulfates	94-113	interleukin 2	Rattus norvegicus	0-4
16193383-5	2005	IL-2 polymer microspheres (IL-2 MS) were produced via the complex coacervation of gelatin and chondroitin sulfate in the presence of IL-2.	Chondroitin Sulfates	94-113	interleukin 2	Rattus norvegicus	27-31
16193383-5	2005	IL-2 polymer microspheres (IL-2 MS) were produced via the complex coacervation of gelatin and chondroitin sulfate in the presence of IL-2.	Chondroitin Sulfates	94-113	interleukin 2	Rattus norvegicus	27-31
16107729-8	2005	We propose that GrB enters cells by nonselective adsorptive pinocytosis, exchanging from chondroitin sulfate on serglycin to anionic components of the cell surface.	Chondroitin Sulfates	89-108	granzyme B	Homo sapiens	16-19
16002044-6	2005	Mutation of serine 180 or glycine 181 in CD44H reduced chondroitin sulfate addition and increased hyaluronan binding, indicating that serine 180 is the site for chondroitin sulfate addition in CD44H and that this negatively regulates hyaluronan binding.	Chondroitin Sulfates	55-74	CD44 molecule (Indian blood group)	Homo sapiens	41-45
16002044-6	2005	Mutation of serine 180 or glycine 181 in CD44H reduced chondroitin sulfate addition and increased hyaluronan binding, indicating that serine 180 is the site for chondroitin sulfate addition in CD44H and that this negatively regulates hyaluronan binding.	Chondroitin Sulfates	161-180	CD44 molecule (Indian blood group)	Homo sapiens	41-45
16111491-5	2005	Exogenous heparin or chondroitin sulfate impaired, in a dose-dependent manner the attachment of C6 glioma cell line to laminin and fibronectin, but not to type IV collagen.	Chondroitin Sulfates	21-40	fibronectin 1	Rattus norvegicus	131-142
16111491-8	2005	Furthermore, heparin and chondroitin sulfate impaired C6 cells proliferation on fibronectin, but not on type IV collagen or laminin.	Chondroitin Sulfates	25-44	fibronectin 1	Rattus norvegicus	80-91
16043844-11	2005	CSPG2 encodes versican, a large chondroitin sulfate proteoglycan, which, in vitreous, binds to hyaluronan and link protein and forms large aggregates that are important for maintaining structural integrity.	Chondroitin Sulfates	32-51	versican	Homo sapiens	0-5
16025132-2	2005	Pregnant women are an exception and are especially susceptible to severe P. falciparum infections resulting from the massive adhesion of parasitized erythrocytes to chondroitin sulphate A (CSA) present on placental syncytiotrophoblasts.	Chondroitin Sulfates	165-187	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	189-192
16043844-11	2005	CSPG2 encodes versican, a large chondroitin sulfate proteoglycan, which, in vitreous, binds to hyaluronan and link protein and forms large aggregates that are important for maintaining structural integrity.	Chondroitin Sulfates	32-51	versican	Homo sapiens	14-22
15982644-1	2005	Receptor-type protein tyrosine phosphatase (RPTP) zeta/beta is a nervous tissue-specific chondroitin sulfate proteoglycan.	Chondroitin Sulfates	89-108	protein tyrosine phosphatase, receptor type Z1	Rattus norvegicus	0-59
15840581-4	2005	This is likely to involve two transesterification reactions in which an ester bond linking an HC to chondroitin sulfate in intact IalphaI is transferred first onto TSG-6 and then onto HA.	Chondroitin Sulfates	100-119	TNF alpha induced protein 6	Homo sapiens	164-169
15797857-6	2005	Sodium orthovanadate, chondroitin sulfate-C, PP1, wortmannin, LY294002, and U0126 inhibit HARP-mediated signaling and HUVEC migration and tube formation.	Chondroitin Sulfates	22-43	pleiotrophin	Homo sapiens	90-94
16254626-2	2005	Heparin and chondroitin sulfate produced by thrombin-activated basophils are good candidates for inductors of these processes.	Chondroitin Sulfates	12-31	coagulation factor II, thrombin	Homo sapiens	44-52
15882562-4	2005	METHODS: Using bovine articular cartilage explants in culture stimulated with IL-1, the effects of physiologically relevant concentrations of GLN and CS on gene expression of inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS), cyclooxygenase-2 (COX-2) and microsomal prostaglandin E synthase-1 (mPGEs1) were assessed with quantitative real-time polymerase chain reaction (Q-RT-PCR).	Chondroitin Sulfates	150-152	nitric oxide synthase 2	Bos taurus	208-212
15894115-0	2005	PKC- and PI3K-dependent but ERK-independent proliferation of murine splenic B cells stimulated by chondroitin sulfate B.	Chondroitin Sulfates	98-117	mitogen-activated protein kinase 1	Mus musculus	28-31
15626448-4	2005	Focusing on this clinical need a disc-shaped BMP carrier was designed as a local delivery system using soluble collagen and chondroitin sulfate.	Chondroitin Sulfates	124-143	bone morphogenetic protein 1	Homo sapiens	45-48
16021525-1	2005	Perlecan is a modular heparan sulphate and/or chondroitin sulphate substituted proteoglycan of basement membrane, vascular tissues and cartilage.	Chondroitin Sulfates	46-66	perlecan	Ovis aries	0-8
15973508-10	2005	Rabbits treated with the GH + CS + fursultiamine revealed a significant reduction in the level of MMP-1.	Chondroitin Sulfates	30-32	interstitial collagenase	Oryctolagus cuniculus	98-103
15872080-7	2005	Immunostaining indicated that the level of chondroitin sulfate was actually increased in the Hspg2(Delta)(3/)(Delta)(3) glomerular basement membrane.	Chondroitin Sulfates	43-62	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	93-98
15892231-2	2005	OBJECTIVES: To assess varying dosages of GU and CS on normal and interleukin-1alpha (IL-1) conditioned equine cartilage explants and rationalise the use of these products.	Chondroitin Sulfates	48-50	interleukin 1 alpha	Equus caballus	65-83
16045544-10	2005	This tumour cell-induced expression of CS, C-6-S and versican appeared to be mediated by TGF-beta and platelet-derived growth factor (PDGF).	Chondroitin Sulfates	39-41	transforming growth factor beta 1	Homo sapiens	89-97
16045544-10	2005	This tumour cell-induced expression of CS, C-6-S and versican appeared to be mediated by TGF-beta and platelet-derived growth factor (PDGF).	Chondroitin Sulfates	43-48	transforming growth factor beta 1	Homo sapiens	89-97
15882562-6	2005	RESULTS: CS and the GLN and CS combination at concentrations attainable in the blood down-regulated IL-1 induced mRNA expression of iNOS at 24 and 48 h post-culture.	Chondroitin Sulfates	9-11	nitric oxide synthase 2	Bos taurus	132-136
15882562-6	2005	RESULTS: CS and the GLN and CS combination at concentrations attainable in the blood down-regulated IL-1 induced mRNA expression of iNOS at 24 and 48 h post-culture.	Chondroitin Sulfates	28-30	nitric oxide synthase 2	Bos taurus	132-136
15882562-8	2005	GLN and CS transiently repressed the cytokine-stimulated mPGEs1 transcript.	Chondroitin Sulfates	8-10	prostaglandin E synthase	Mus musculus	57-63
15882562-10	2005	Repression of COX-2 transcripts by GLN and CS was accompanied by concomitant reduction in PGE(2).	Chondroitin Sulfates	43-45	prostaglandin-endoperoxide synthase 2	Bos taurus	14-19
15699048-9	2005	In addition to immobilized hyaluronan, full-length TSG-6 also binds free hyaluronan and all chondroitin sulfate isoforms under physiological conditions.	Chondroitin Sulfates	92-111	tumor necrosis factor alpha induced protein 6	Mus musculus	51-56
15699048-0	2005	TSG-6 protein binding to glycosaminoglycans: formation of stable complexes with hyaluronan and binding to chondroitin sulfates.	Chondroitin Sulfates	106-126	tumor necrosis factor alpha induced protein 6	Mus musculus	0-5
15728209-8	2005	Osteoprotegerin-induced deactivation of monocyte chemotaxis toward different chemokines is due to interaction of osteoprotegerin with heparan sulfate and chondroitin sulfate.	Chondroitin Sulfates	154-173	TNF receptor superfamily member 11b	Homo sapiens	0-15
15728209-8	2005	Osteoprotegerin-induced deactivation of monocyte chemotaxis toward different chemokines is due to interaction of osteoprotegerin with heparan sulfate and chondroitin sulfate.	Chondroitin Sulfates	154-173	TNF receptor superfamily member 11b	Homo sapiens	113-128
15653696-12	2005	A TSG-6 hydroxyl group reacts with the ester bond between the alpha-carbonyl of the C-terminal Asp residues of HC1 or HC2 and carbon-6 of an internal N-acetylgalactosamine of the chondroitin-4-sulfate chain.	Chondroitin Sulfates	179-200	TNF alpha induced protein 6	Homo sapiens	2-7
15576472-7	2005	CD97 EGF-like repeat 4 is known to bind chondroitin sulfate.	Chondroitin Sulfates	40-59	adhesion G protein-coupled receptor E5	Homo sapiens	0-4
15792947-5	2005	Treatment with CS plus GS, but not CS alone, significantly reduced clinical scores, incidences of disease, joint temperatures, and joint and serum IL-1beta levels.	Chondroitin Sulfates	15-17	interleukin 1 beta	Rattus norvegicus	147-155
15792947-6	2005	Treatment with CS alone and CS plus GS inhibited the production of edema and prevented raised levels of joint MMP-9 associated with arthritis.	Chondroitin Sulfates	15-17	matrix metallopeptidase 9	Rattus norvegicus	110-115
15792947-6	2005	Treatment with CS alone and CS plus GS inhibited the production of edema and prevented raised levels of joint MMP-9 associated with arthritis.	Chondroitin Sulfates	28-30	matrix metallopeptidase 9	Rattus norvegicus	110-115
15653696-12	2005	A TSG-6 hydroxyl group reacts with the ester bond between the alpha-carbonyl of the C-terminal Asp residues of HC1 or HC2 and carbon-6 of an internal N-acetylgalactosamine of the chondroitin-4-sulfate chain.	Chondroitin Sulfates	179-200	CYCS pseudogene 39	Homo sapiens	111-114
15653696-12	2005	A TSG-6 hydroxyl group reacts with the ester bond between the alpha-carbonyl of the C-terminal Asp residues of HC1 or HC2 and carbon-6 of an internal N-acetylgalactosamine of the chondroitin-4-sulfate chain.	Chondroitin Sulfates	179-200	CYCS pseudogene 38	Homo sapiens	118-121
15693006-2	2005	Chondroitin sulfates (CS) have recently been identified as ligands for EMR2 and CD97.	Chondroitin Sulfates	0-20	adhesion G protein-coupled receptor E2	Homo sapiens	71-75
15632143-0	2005	Heparin-binding growth factor, pleiotrophin, mediates neuritogenic activity of embryonic pig brain-derived chondroitin sulfate/dermatan sulfate hybrid chains.	Chondroitin Sulfates	107-126	pleiotrophin	Sus scrofa	31-43
15693006-2	2005	Chondroitin sulfates (CS) have recently been identified as ligands for EMR2 and CD97.	Chondroitin Sulfates	0-20	adhesion G protein-coupled receptor E5	Homo sapiens	80-84
15693006-2	2005	Chondroitin sulfates (CS) have recently been identified as ligands for EMR2 and CD97.	Chondroitin Sulfates	22-24	adhesion G protein-coupled receptor E2	Homo sapiens	71-75
15693006-2	2005	Chondroitin sulfates (CS) have recently been identified as ligands for EMR2 and CD97.	Chondroitin Sulfates	22-24	adhesion G protein-coupled receptor E5	Homo sapiens	80-84
15974955-4	2005	The superoxide dismutase-chondroitin sulphate conjugate markedly reduced the thrombus mass, while the catalase-chondroitin sulphate conjugate predominantly preserved blood flow.	Chondroitin Sulfates	111-131	catalase	Rattus norvegicus	102-110
15537641-0	2005	Porcine dentin sialoprotein is a proteoglycan with glycosaminoglycan chains containing chondroitin 6-sulfate.	Chondroitin Sulfates	87-108	dentin sialophosphoprotein	Sus scrofa	8-27
15537641-8	2005	Glycosaminoglycanases with assorted glycosaminoglycan (GAG) cleavage specificities coupled with Western analyses of the cleaved GAG "stubs" demonstrated that the DSP GAG attachments contain chondroitin 6-sulfate, but not keratan sulfate, heparan sulfate, chondroitin, or chondroitin 4-sulfate.	Chondroitin Sulfates	190-211	dentin sialophosphoprotein	Sus scrofa	162-165
15537641-8	2005	Glycosaminoglycanases with assorted glycosaminoglycan (GAG) cleavage specificities coupled with Western analyses of the cleaved GAG "stubs" demonstrated that the DSP GAG attachments contain chondroitin 6-sulfate, but not keratan sulfate, heparan sulfate, chondroitin, or chondroitin 4-sulfate.	Chondroitin Sulfates	271-292	dentin sialophosphoprotein	Sus scrofa	162-165
15974955-6	2005	A single-bolus intravenous injection of the combination between superoxide dismutase-chondroitin sulphate and catalase-chondroitin sulphate covalent conjugates had a significantly lower antithrombotic effect compared with that of the superoxide dismutase-chondroitin sulphate-catalase bienzymic covalent conjugate.	Chondroitin Sulfates	119-139	catalase	Rattus norvegicus	110-118
15974955-6	2005	A single-bolus intravenous injection of the combination between superoxide dismutase-chondroitin sulphate and catalase-chondroitin sulphate covalent conjugates had a significantly lower antithrombotic effect compared with that of the superoxide dismutase-chondroitin sulphate-catalase bienzymic covalent conjugate.	Chondroitin Sulfates	119-139	catalase	Rattus norvegicus	276-284
15974955-6	2005	A single-bolus intravenous injection of the combination between superoxide dismutase-chondroitin sulphate and catalase-chondroitin sulphate covalent conjugates had a significantly lower antithrombotic effect compared with that of the superoxide dismutase-chondroitin sulphate-catalase bienzymic covalent conjugate.	Chondroitin Sulfates	85-105	catalase	Rattus norvegicus	276-284
15498814-0	2005	Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells.	Chondroitin Sulfates	103-122	adhesion G protein-coupled receptor E5	Homo sapiens	26-30
15929608-0	2005	Chondroitin sulfate and hyaluronic acid (500-730 kda) inhibit stromelysin-1 synthesis in human osteoarthritic chondrocytes.	Chondroitin Sulfates	0-19	matrix metallopeptidase 3	Homo sapiens	62-75
15929608-5	2005	However, there are few studies evaluating the in vitro effect of CS and HA on MMP-3 synthesis in human chondrocyte cultures from OA patients.	Chondroitin Sulfates	65-67	matrix metallopeptidase 3	Homo sapiens	78-83
15929608-6	2005	Thus, the aim of the present study was to analyze the effect of CS and HA (500-730 kDa) on MMP-3 synthesis induced by interleukin-1beta (IL-1beta) in chondrocytes from patients with hip OA.	Chondroitin Sulfates	64-66	matrix metallopeptidase 3	Homo sapiens	91-96
15929608-6	2005	Thus, the aim of the present study was to analyze the effect of CS and HA (500-730 kDa) on MMP-3 synthesis induced by interleukin-1beta (IL-1beta) in chondrocytes from patients with hip OA.	Chondroitin Sulfates	64-66	interleukin 1 beta	Homo sapiens	118-135
15929608-6	2005	Thus, the aim of the present study was to analyze the effect of CS and HA (500-730 kDa) on MMP-3 synthesis induced by interleukin-1beta (IL-1beta) in chondrocytes from patients with hip OA.	Chondroitin Sulfates	64-66	interleukin 1 beta	Homo sapiens	137-145
15929608-8	2005	The results revealed that both CS and HA (500-730 kDa) inhibited MMP-3 synthesis induced by IL-1beta in human OA chondrocytes.	Chondroitin Sulfates	31-33	matrix metallopeptidase 3	Homo sapiens	65-70
15929608-8	2005	The results revealed that both CS and HA (500-730 kDa) inhibited MMP-3 synthesis induced by IL-1beta in human OA chondrocytes.	Chondroitin Sulfates	31-33	interleukin 1 beta	Homo sapiens	92-100
15498814-4	2005	Using fluorescent beads coated with soluble recombinant CD97 and EMR2 protein, and isoform-specific monoclonal antibodies, we have determined the cellular and molecular characteristics of the interaction with CS.	Chondroitin Sulfates	209-211	adhesion G protein-coupled receptor E5	Homo sapiens	56-60
15459010-5	2005	Both RANTES-triggered arrest and PF4 binding involved monocytic chondroitin sulfate.	Chondroitin Sulfates	64-83	C-C motif chemokine ligand 5	Homo sapiens	5-11
15459010-5	2005	Both RANTES-triggered arrest and PF4 binding involved monocytic chondroitin sulfate.	Chondroitin Sulfates	64-83	platelet factor 4	Homo sapiens	33-36
15498814-0	2005	Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells.	Chondroitin Sulfates	103-122	adhesion G protein-coupled receptor E2	Homo sapiens	35-39
15498814-3	2005	The first two EGF domains of CD97 (but not EMR2) bind CD55 (decay-accelerating factor), while the fourth EGF domain of both CD97 and EMR2 interacts with the glycosaminoglycan chondroitin sulfate (CS).	Chondroitin Sulfates	175-194	adhesion G protein-coupled receptor E5	Homo sapiens	29-33
15498814-3	2005	The first two EGF domains of CD97 (but not EMR2) bind CD55 (decay-accelerating factor), while the fourth EGF domain of both CD97 and EMR2 interacts with the glycosaminoglycan chondroitin sulfate (CS).	Chondroitin Sulfates	175-194	adhesion G protein-coupled receptor E5	Homo sapiens	124-128
15498814-3	2005	The first two EGF domains of CD97 (but not EMR2) bind CD55 (decay-accelerating factor), while the fourth EGF domain of both CD97 and EMR2 interacts with the glycosaminoglycan chondroitin sulfate (CS).	Chondroitin Sulfates	175-194	adhesion G protein-coupled receptor E2	Homo sapiens	133-137
15498814-3	2005	The first two EGF domains of CD97 (but not EMR2) bind CD55 (decay-accelerating factor), while the fourth EGF domain of both CD97 and EMR2 interacts with the glycosaminoglycan chondroitin sulfate (CS).	Chondroitin Sulfates	196-198	adhesion G protein-coupled receptor E5	Homo sapiens	29-33
15498814-4	2005	Using fluorescent beads coated with soluble recombinant CD97 and EMR2 protein, and isoform-specific monoclonal antibodies, we have determined the cellular and molecular characteristics of the interaction with CS.	Chondroitin Sulfates	209-211	adhesion G protein-coupled receptor E2	Homo sapiens	65-69
15498814-6	2005	The interaction between CD97/EMR2 and CS may therefore play a role in the interaction of activated T cells, dendritic cells, and macrophages with B cells.	Chondroitin Sulfates	38-40	adhesion G protein-coupled receptor E5	Homo sapiens	24-28
15498814-6	2005	The interaction between CD97/EMR2 and CS may therefore play a role in the interaction of activated T cells, dendritic cells, and macrophages with B cells.	Chondroitin Sulfates	38-40	adhesion G protein-coupled receptor E2	Homo sapiens	29-33
15603739-3	2004	The thrombospondin repeats of Sema5A physically interact with the glycosaminoglycan portion of both chondroitin sulfate proteoglycans (CSPGs) and heparan sulfate proteoglycans (HSPGs).	Chondroitin Sulfates	100-119	semaphorin 5A	Homo sapiens	30-36
15331613-0	2004	Glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C.	Chondroitin Sulfates	23-42	chondroitin sulfate proteoglycan 5	Mus musculus	81-94
15347686-7	2004	The ratio of chondroitin sulfate to heparan sulfate likewise increased on syndecan-1 from gel culture.	Chondroitin Sulfates	13-32	syndecan 1	Mus musculus	74-84
15331613-1	2004	Neuroglycan C (NGC) is a membrane-spanning chondroitin sulfate (CS) proteoglycan that is expressed predominantly in the central nervous system (CNS).	Chondroitin Sulfates	43-62	chondroitin sulfate proteoglycan 5	Mus musculus	0-13
15331613-1	2004	Neuroglycan C (NGC) is a membrane-spanning chondroitin sulfate (CS) proteoglycan that is expressed predominantly in the central nervous system (CNS).	Chondroitin Sulfates	43-62	chondroitin sulfate proteoglycan 5	Mus musculus	15-18
15331613-1	2004	Neuroglycan C (NGC) is a membrane-spanning chondroitin sulfate (CS) proteoglycan that is expressed predominantly in the central nervous system (CNS).	Chondroitin Sulfates	64-66	chondroitin sulfate proteoglycan 5	Mus musculus	0-13
15331613-1	2004	Neuroglycan C (NGC) is a membrane-spanning chondroitin sulfate (CS) proteoglycan that is expressed predominantly in the central nervous system (CNS).	Chondroitin Sulfates	64-66	chondroitin sulfate proteoglycan 5	Mus musculus	15-18
15331613-5	2004	When a mouse NGC cDNA was transfected into COS 1, PC12D, and Neuro 2a cells, only Neuro 2a cells, a mouse neuroblastoma cell line, expressed NGC bearing CS chains.	Chondroitin Sulfates	153-155	chondroitin sulfate proteoglycan 5	Mus musculus	13-16
15331613-7	2004	This suggests that the addition of CS chains to the NGC core protein is regulated in a manner different from that of other CS proteoglycans.	Chondroitin Sulfates	35-37	chondroitin sulfate proteoglycan 5	Mus musculus	52-55
15331613-8	2004	As the first step in investigating the CS glycosylation mechanism using Neuro 2a cells, we determined the CS attachment site as Ser-123 on the NGC core protein by site-directed mutagenesis.	Chondroitin Sulfates	39-41	chondroitin sulfate proteoglycan 5	Mus musculus	143-146
15331613-8	2004	As the first step in investigating the CS glycosylation mechanism using Neuro 2a cells, we determined the CS attachment site as Ser-123 on the NGC core protein by site-directed mutagenesis.	Chondroitin Sulfates	106-108	chondroitin sulfate proteoglycan 5	Mus musculus	143-146
15520249-2	2004	The condition is precipitated by accumulation of parasite-infected erythrocytes (IEs) in the placenta, and this process is mediated by parasite-encoded variant surface antigens (VSA) binding to chondroitin sulfate A (CSA).	Chondroitin Sulfates	194-215	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	217-220
15226301-4	2004	These sites, like LRP-1, are sensitive to receptor-associated protein and calcium depletion but, unlike LRP-1, are also sensitive to chondroitin sulfate and heparin and capable of directly binding ligands, which do not bind to LRP-1.	Chondroitin Sulfates	133-152	LDL receptor related protein 1	Bos taurus	18-23
15234978-4	2004	Both surface plasmon resonance analysis and enzyme-linked immunosorbent assay revealed that MDP1 bound to HA, heparin, and chondroitin sulfate.	Chondroitin Sulfates	123-142	magnesium dependent phosphatase 1	Homo sapiens	92-96
15226297-0	2004	Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors.	Chondroitin Sulfates	0-19	syndecan 1	Mus musculus	30-40
15226297-0	2004	Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors.	Chondroitin Sulfates	0-19	syndecan 4	Mus musculus	45-55
15226297-4	2004	The CS chains of the two syndecans comprised nonsulfated, 4-O-, 6-O-, and 4,6-O-disulfated N-acetylgalactosamine-containing disaccharide units and were significantly different, with a higher degree of sulfation for syndecan-4.	Chondroitin Sulfates	4-6	syndecan 4	Mus musculus	215-225
15226297-6	2004	Stronger binding of MK and PTN to the CS chains of syndecan-4 than those of syndecan-1 was revealed, supporting the structural and functional differences.	Chondroitin Sulfates	38-40	midkine	Mus musculus	20-22
15226297-6	2004	Stronger binding of MK and PTN to the CS chains of syndecan-4 than those of syndecan-1 was revealed, supporting the structural and functional differences.	Chondroitin Sulfates	38-40	pleiotrophin	Mus musculus	27-30
15226297-6	2004	Stronger binding of MK and PTN to the CS chains of syndecan-4 than those of syndecan-1 was revealed, supporting the structural and functional differences.	Chondroitin Sulfates	38-40	syndecan 4	Mus musculus	51-61
15226297-7	2004	Intriguingly, removal of the CS chains decreased the association and dissociation rate constants of MK, PTN, and bFGF for both syndecans, suggesting the simultaneous binding of these growth factors to both types of chains, producing a ternary complex that transfers the growth factors to the corresponding cell surface receptors more efficiently compared with the HS chains alone.	Chondroitin Sulfates	29-31	midkine	Mus musculus	100-102
15226297-7	2004	Intriguingly, removal of the CS chains decreased the association and dissociation rate constants of MK, PTN, and bFGF for both syndecans, suggesting the simultaneous binding of these growth factors to both types of chains, producing a ternary complex that transfers the growth factors to the corresponding cell surface receptors more efficiently compared with the HS chains alone.	Chondroitin Sulfates	29-31	pleiotrophin	Mus musculus	104-107
15226297-7	2004	Intriguingly, removal of the CS chains decreased the association and dissociation rate constants of MK, PTN, and bFGF for both syndecans, suggesting the simultaneous binding of these growth factors to both types of chains, producing a ternary complex that transfers the growth factors to the corresponding cell surface receptors more efficiently compared with the HS chains alone.	Chondroitin Sulfates	29-31	fibroblast growth factor 2	Mus musculus	113-117
15226297-8	2004	The involvement of the core protein was also shown in the binding of MK and PTN to syndecan-1, suggesting the possibility of cooperation with the HS and/or CS chains in the binding of these growth factors and their delivery to the cell surface receptors.	Chondroitin Sulfates	156-158	syndecan 1	Mus musculus	83-93
15358546-4	2004	Both chondroitin sulfate and dermatan sulfate, in addition to heparin, were found to bind VWF equally well.	Chondroitin Sulfates	5-24	von Willebrand factor	Homo sapiens	90-93
15350207-4	2004	This study investigates whether chondroitin sulphate A (CSA) binding parasites express trypsin-resistant variant surface antigens (VSA) that bind female-specific antibodies induced as a result of pregnancy associated malaria (PAM).	Chondroitin Sulfates	32-54	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	56-59
15365236-0	2004	Mucosal mast cell-derived chondroitin sulphate levels in and worm expulsion from FcRgamma-knockout mice following oral challenge with Strongyloides venezuelensis.	Chondroitin Sulfates	26-46	Fc receptor, IgE, high affinity I, gamma polypeptide	Mus musculus	81-89
15337504-6	2004	By blocking the coupling of CS chains to the core protein with p-nitrophenyl-beta-D-xyloside and by chondroitinase ABC treatment, we demonstrated that the increased accumulation of pericellular CS is accompanied by increased cell attachment to immobilized hyaluronic acid (HA), while the expression of cell surface CD44 remains unaltered.	Chondroitin Sulfates	194-196	CD44 molecule (Indian blood group)	Homo sapiens	315-319
15337504-7	2004	Since the exogenous TGFbeta1 affects ECV304 cells in a similar manner, and anti-TGFbeta1-neutralizing antibody cancels the effect of high glucose, we suggest the involvement of TGFbeta1 in the development of endothelial cell response to high glucose in terms of CS accumulation and cell binding to HA.	Chondroitin Sulfates	262-264	transforming growth factor beta 1	Homo sapiens	80-88
15337504-7	2004	Since the exogenous TGFbeta1 affects ECV304 cells in a similar manner, and anti-TGFbeta1-neutralizing antibody cancels the effect of high glucose, we suggest the involvement of TGFbeta1 in the development of endothelial cell response to high glucose in terms of CS accumulation and cell binding to HA.	Chondroitin Sulfates	262-264	transforming growth factor beta 1	Homo sapiens	80-88
15147241-0	2004	Chondroitin sulphate structure affects its immunological activities on murine splenocytes sensitized with ovalbumin.	Chondroitin Sulfates	0-20	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	106-115
15147241-2	2004	We reported previously that chondroitin 4-sulphate (CS-A) up-regulates the antigen-specific Th1 immune response of murine splenocytes sensitized with ovalbumin in vitro, and that CS suppresses the antigen-specific IgE responses.	Chondroitin Sulfates	52-56	negative elongation factor complex member C/D, Th1l	Mus musculus	92-95
15147241-8	2004	Furthermore, rat anti-mouse CD62L antibody, an antibody to L-selectin, inhibits the Th1-promoting activity of CS.	Chondroitin Sulfates	110-112	selectin, lymphocyte	Mus musculus	28-33
15147241-8	2004	Furthermore, rat anti-mouse CD62L antibody, an antibody to L-selectin, inhibits the Th1-promoting activity of CS.	Chondroitin Sulfates	110-112	selectin, lymphocyte	Mus musculus	59-69
15147241-2	2004	We reported previously that chondroitin 4-sulphate (CS-A) up-regulates the antigen-specific Th1 immune response of murine splenocytes sensitized with ovalbumin in vitro, and that CS suppresses the antigen-specific IgE responses.	Chondroitin Sulfates	52-56	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	150-159
15147241-8	2004	Furthermore, rat anti-mouse CD62L antibody, an antibody to L-selectin, inhibits the Th1-promoting activity of CS.	Chondroitin Sulfates	110-112	negative elongation factor complex member C/D, Th1l	Mus musculus	84-87
15147241-2	2004	We reported previously that chondroitin 4-sulphate (CS-A) up-regulates the antigen-specific Th1 immune response of murine splenocytes sensitized with ovalbumin in vitro, and that CS suppresses the antigen-specific IgE responses.	Chondroitin Sulfates	52-54	negative elongation factor complex member C/D, Th1l	Mus musculus	92-95
15147241-2	2004	We reported previously that chondroitin 4-sulphate (CS-A) up-regulates the antigen-specific Th1 immune response of murine splenocytes sensitized with ovalbumin in vitro, and that CS suppresses the antigen-specific IgE responses.	Chondroitin Sulfates	52-54	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	150-159
15147241-4	2004	While the presence of some O-sulpho groups appear to be essential for activity, CS-A, and synthetically prepared, partially O-sulphonated CS, induce higher Th1-promoted activity than synthetically prepared, fully O-sulphonated CS.	Chondroitin Sulfates	80-84	negative elongation factor complex member C/D, Th1l	Mus musculus	156-159
15147241-4	2004	While the presence of some O-sulpho groups appear to be essential for activity, CS-A, and synthetically prepared, partially O-sulphonated CS, induce higher Th1-promoted activity than synthetically prepared, fully O-sulphonated CS.	Chondroitin Sulfates	80-82	negative elongation factor complex member C/D, Th1l	Mus musculus	156-159
15147241-4	2004	While the presence of some O-sulpho groups appear to be essential for activity, CS-A, and synthetically prepared, partially O-sulphonated CS, induce higher Th1-promoted activity than synthetically prepared, fully O-sulphonated CS.	Chondroitin Sulfates	138-140	negative elongation factor complex member C/D, Th1l	Mus musculus	156-159
15147241-5	2004	CS-A induces an activity greater than chondroitin sulphate B (CS-B) or chondroitin 6-sulphate (CS-C).	Chondroitin Sulfates	0-4	excision repair cross-complementing rodent repair deficiency, complementation group 6	Mus musculus	38-60
15147241-6	2004	In addition, chondroitin sulphate E (CS-E) induces greater activity than CS-A or CS-D.	Chondroitin Sulfates	73-77	cystathionase (cystathionine gamma-lyase)	Mus musculus	13-35
15147241-6	2004	In addition, chondroitin sulphate E (CS-E) induces greater activity than CS-A or CS-D.	Chondroitin Sulfates	73-77	cystathionase (cystathionine gamma-lyase)	Mus musculus	37-41
15208308-1	2004	The human hyaluronan receptor for endocytosis (hHARE) mediates the endocytic clearance of hyaluronan (HA) and chondroitin sulfate from lymph fluid and blood.	Chondroitin Sulfates	110-129	stabilin 2	Homo sapiens	10-45
15269982-6	2004	Free heparin, LMW heparin, CS,HA and carrageenans competed for the binding of IFN-gamma to HBC with significant different ability.	Chondroitin Sulfates	27-29	interferon gamma	Homo sapiens	78-87
15208308-1	2004	The human hyaluronan receptor for endocytosis (hHARE) mediates the endocytic clearance of hyaluronan (HA) and chondroitin sulfate from lymph fluid and blood.	Chondroitin Sulfates	110-129	stabilin 2	Homo sapiens	47-52
15198666-2	2004	Agrin"s neurite inhibitory activity is confined to the N-terminal segment of the protein (agrin N150), which contains heparan sulfate (HS) and chondroitin sulfate (CS) side chains.	Chondroitin Sulfates	143-162	agrin	Gallus gallus	0-5
15198666-2	2004	Agrin"s neurite inhibitory activity is confined to the N-terminal segment of the protein (agrin N150), which contains heparan sulfate (HS) and chondroitin sulfate (CS) side chains.	Chondroitin Sulfates	143-162	agrin	Gallus gallus	90-95
15198666-2	2004	Agrin"s neurite inhibitory activity is confined to the N-terminal segment of the protein (agrin N150), which contains heparan sulfate (HS) and chondroitin sulfate (CS) side chains.	Chondroitin Sulfates	164-166	agrin	Gallus gallus	0-5
15198666-2	2004	Agrin"s neurite inhibitory activity is confined to the N-terminal segment of the protein (agrin N150), which contains heparan sulfate (HS) and chondroitin sulfate (CS) side chains.	Chondroitin Sulfates	164-166	agrin	Gallus gallus	90-95
15460450-9	2004	However, Chondroitin sulfate (CS) decreased the levels of MDA, but increased the levels of SOD, CAT and GPx in a dose-dependent manner.	Chondroitin Sulfates	9-28	catalase	Rattus norvegicus	96-99
15460450-9	2004	However, Chondroitin sulfate (CS) decreased the levels of MDA, but increased the levels of SOD, CAT and GPx in a dose-dependent manner.	Chondroitin Sulfates	30-32	catalase	Rattus norvegicus	96-99
15215498-4	2004	C6ST-1 catalyzes the modifying step of chondroitin sulfate (CS) synthesis by transferring sulfate to the C-6 position of the N-acetylgalactosamine of chondroitin.	Chondroitin Sulfates	39-58	carbohydrate sulfotransferase 3	Homo sapiens	0-6
15215498-4	2004	C6ST-1 catalyzes the modifying step of chondroitin sulfate (CS) synthesis by transferring sulfate to the C-6 position of the N-acetylgalactosamine of chondroitin.	Chondroitin Sulfates	60-62	carbohydrate sulfotransferase 3	Homo sapiens	0-6
15215498-7	2004	Disaccharide composition analysis of CS chains by anion-exchange HPLC shows that both Delta HexA-GalNAc(6S) and Delta HexA(2S)-GalNAc(6S) were significantly reduced in the patient"s cells and that Delta HexA-GalNAc(4S,6S), undetectable in controls, was elevated.	Chondroitin Sulfates	37-39	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	97-106
15215498-7	2004	Disaccharide composition analysis of CS chains by anion-exchange HPLC shows that both Delta HexA-GalNAc(6S) and Delta HexA(2S)-GalNAc(6S) were significantly reduced in the patient"s cells and that Delta HexA-GalNAc(4S,6S), undetectable in controls, was elevated.	Chondroitin Sulfates	37-39	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Homo sapiens	127-136
15215498-9	2004	Our results indicate that the mutation in CHST3 described here causes a specific but generalized defect of CS chain sulfation resulting in chondrodysplasia with major involvement of the spine.	Chondroitin Sulfates	107-109	carbohydrate sulfotransferase 3	Homo sapiens	42-47
14681222-3	2004	TN-R can be modified with three distinct sulfated oligosaccharide structures: HNK-1 (SO(4)-3-GlcUAbeta1,3Galbeta1,4GlcNAc), GalNAc-4-SO(4), and chondroitin sulfate.	Chondroitin Sulfates	144-163	tenascin R	Rattus norvegicus	0-4
15158613-0	2004	CD44-chondroitin sulfate interactions mediate leukocyte rolling under physiological flow conditions.	Chondroitin Sulfates	5-24	CD44 antigen	Mus musculus	0-4
15158613-2	2004	We previously reported that the recombinant CD44 protein binds to other GAGs, including chondroitin sulfates (CS), although the physiological significance of this interaction has remained unclear.	Chondroitin Sulfates	88-108	CD44 antigen	Mus musculus	44-48
15158613-2	2004	We previously reported that the recombinant CD44 protein binds to other GAGs, including chondroitin sulfates (CS), although the physiological significance of this interaction has remained unclear.	Chondroitin Sulfates	110-112	CD44 antigen	Mus musculus	44-48
15158613-3	2004	Here we report that the CD44 expressed on mouse lymphoma BW5147 cells supports cell binding to immobilized CS under static conditions and mediates cell rolling in CS-coated glass capillary tubes under shear stresses ranging from 0.5 to 1.5 dyn/cm(2), which is within the physiological range of forces in venules.	Chondroitin Sulfates	107-109	CD44 antigen	Mus musculus	24-28
15158613-3	2004	Here we report that the CD44 expressed on mouse lymphoma BW5147 cells supports cell binding to immobilized CS under static conditions and mediates cell rolling in CS-coated glass capillary tubes under shear stresses ranging from 0.5 to 1.5 dyn/cm(2), which is within the physiological range of forces in venules.	Chondroitin Sulfates	163-165	CD44 antigen	Mus musculus	24-28
15296942-3	2004	Chick perlecan is, like its human and mouse homologue, a hybrid heparan sulfate/chondroitin sulfate proteoglycan with a core protein of 400 KD.	Chondroitin Sulfates	80-99	heparan sulfate proteoglycan 2	Gallus gallus	6-14
15158613-5	2004	To address the role of the CD44-CS interaction in vivo, we examined the tissue localization of the CS that interacts with CD44.	Chondroitin Sulfates	99-101	CD44 antigen	Mus musculus	122-126
15158613-6	2004	Interestingly, a recombinant CD44 fusion protein bound to hepatic sinuosoidal endothelial cells where CS was also expressed, as assessed by immunohistochemistry.	Chondroitin Sulfates	102-104	CD44 antigen	Mus musculus	29-33
14977881-7	2004	Serum-free medium supplemented with either a synthetic peptide containing the EGF motif of the domain V of perlecan or chondroitin 4-sulfate, a glycosaminoglycan anchored on the domain V of perlecan, increased ERK 1/2 phosphorylation and Bcl-xl protein levels while inhibiting apoptosis of VSMC.	Chondroitin Sulfates	119-140	mitogen-activated protein kinase 3	Homo sapiens	210-217
14977881-7	2004	Serum-free medium supplemented with either a synthetic peptide containing the EGF motif of the domain V of perlecan or chondroitin 4-sulfate, a glycosaminoglycan anchored on the domain V of perlecan, increased ERK 1/2 phosphorylation and Bcl-xl protein levels while inhibiting apoptosis of VSMC.	Chondroitin Sulfates	119-140	BCL2 like 1	Homo sapiens	238-244
15008724-4	2004	The amount of CS immunostaining was estimated by semi-quantitative scoring and correlated with prostate-specific antigen (PSA) level and prostate size.	Chondroitin Sulfates	14-16	kallikrein related peptidase 3	Homo sapiens	95-126
14701864-0	2004	ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.	Chondroitin Sulfates	210-229	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	0-7
14701864-0	2004	ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage by glycosylphosphatidyl inositol-anchored membrane type 4-matrix metalloproteinase and binding of the activated proteinase to chondroitin sulfate and heparan sulfate on syndecan-1.	Chondroitin Sulfates	210-229	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	9-22
14701864-5	2004	Specific glycosaminoglycan lyase digestions, followed by product analyses using fluorescence-assisted carbohydrate electrophoresis and immunoprecipitation experiments, showed that the p53 form is associated with syndecan-1 through both chondroitin sulfate and heparan sulfate.	Chondroitin Sulfates	236-255	tumor protein p53	Homo sapiens	184-187
14701864-5	2004	Specific glycosaminoglycan lyase digestions, followed by product analyses using fluorescence-assisted carbohydrate electrophoresis and immunoprecipitation experiments, showed that the p53 form is associated with syndecan-1 through both chondroitin sulfate and heparan sulfate.	Chondroitin Sulfates	236-255	syndecan 1	Homo sapiens	212-222
15089041-0	2004	The preventive inhibition of chondroitin sulfate against the CCl4-induced oxidative stress of subcellular level.	Chondroitin Sulfates	29-48	C-C motif chemokine ligand 4	Rattus norvegicus	61-65
14585696-0	2004	Degradation of a collagen-chondroitin-6-sulfate matrix by collagenase and by chondroitinase.	Chondroitin Sulfates	26-47	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	77-91
14645229-1	2004	Cathepsin K, a lysosomal papain-like cysteine protease, forms collagenolytically highly active complexes with chondroitin sulfate and represents the most potent mammalian collagenase.	Chondroitin Sulfates	110-129	cathepsin K	Homo sapiens	0-11
15028960-4	2004	Intraperitoneal pretreatment of rats with hyaluronic acid or chondroitin-4-sulfate or with both compounds ameliorated pancreatic cell conditions; restored the endogenous antioxidants reduced glutathione, catalase and superoxide dismutase; limited cell membrane peroxidation; and reduced neutrophil activation.	Chondroitin Sulfates	61-82	catalase	Rattus norvegicus	204-212
15009704-7	2004	CD44, a cell surface receptor known to bind hyaluronan, not infrequently exists as a proteoglycan, decorated with various glycosaminoglycan chains including heparan sulfate and chondroitin sulfate, and as such can bind fibronectin.	Chondroitin Sulfates	177-196	CD44 molecule (Indian blood group)	Homo sapiens	0-4
14741373-2	2004	In this study, the appican CS chain from rat C6 glioma cells was shown to specifically bind several growth/differentiation factors including midkine (MK) and pleiotrophin (PTN).	Chondroitin Sulfates	27-29	midkine	Rattus norvegicus	141-148
15009727-6	2004	Although melanoma-associated chondroitin sulfate proteoglycan coexpression with a subset of beta 1 integrin bright basal keratinocytes within the epidermis suggests that melanoma-associated chondroitin sulfate proteoglycan colocalizes with epidermal stem cells, melanoma-associated chondroitin sulfate proteoglycan expression within the hair follicle was more complex and multiple subpopulations of basal outer root sheath keratinocytes are described.	Chondroitin Sulfates	190-209	integrin subunit beta 1	Homo sapiens	92-107
15009727-6	2004	Although melanoma-associated chondroitin sulfate proteoglycan coexpression with a subset of beta 1 integrin bright basal keratinocytes within the epidermis suggests that melanoma-associated chondroitin sulfate proteoglycan colocalizes with epidermal stem cells, melanoma-associated chondroitin sulfate proteoglycan expression within the hair follicle was more complex and multiple subpopulations of basal outer root sheath keratinocytes are described.	Chondroitin Sulfates	190-209	integrin subunit beta 1	Homo sapiens	92-107
14757526-1	2004	Protein tyrosine phosphatase zeta (PTPzeta)/RPTPbeta is a chondroitin sulfate proteoglycan predominantly expressed in the brain.	Chondroitin Sulfates	58-77	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	0-43
14757526-1	2004	Protein tyrosine phosphatase zeta (PTPzeta)/RPTPbeta is a chondroitin sulfate proteoglycan predominantly expressed in the brain.	Chondroitin Sulfates	58-77	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	44-52
14741373-2	2004	In this study, the appican CS chain from rat C6 glioma cells was shown to specifically bind several growth/differentiation factors including midkine (MK) and pleiotrophin (PTN).	Chondroitin Sulfates	27-29	midkine	Rattus norvegicus	150-152
14741373-2	2004	In this study, the appican CS chain from rat C6 glioma cells was shown to specifically bind several growth/differentiation factors including midkine (MK) and pleiotrophin (PTN).	Chondroitin Sulfates	27-29	pleiotrophin	Rattus norvegicus	158-170
14741373-2	2004	In this study, the appican CS chain from rat C6 glioma cells was shown to specifically bind several growth/differentiation factors including midkine (MK) and pleiotrophin (PTN).	Chondroitin Sulfates	27-29	pleiotrophin	Rattus norvegicus	172-175
14972565-3	2004	Bovine lactoferrin (BLf) was a strong inhibitor of HSV-1 infection in cells expressing either heparan sulfate (HS) or chondroitin sulfate (CS) or both, but was ineffective or less efficient in GAG-deficient cells or in cells treated with GAG-degrading enzymes.	Chondroitin Sulfates	118-137	lactotransferrin	Bos taurus	7-18
14972565-3	2004	Bovine lactoferrin (BLf) was a strong inhibitor of HSV-1 infection in cells expressing either heparan sulfate (HS) or chondroitin sulfate (CS) or both, but was ineffective or less efficient in GAG-deficient cells or in cells treated with GAG-degrading enzymes.	Chondroitin Sulfates	139-141	lactotransferrin	Bos taurus	7-18
14972565-4	2004	In contrast to wild-type HSV-1, virus mutants devoid of glycoprotein C (gC) were significantly less inhibited by lactoferrin in GAG-expressing cells, indicating that lactoferrin interfered with the binding of viral gC to cell surface HS and/or CS.	Chondroitin Sulfates	244-246	lactotransferrin	Bos taurus	166-177
14972565-5	2004	Finally, we demonstrated that lactoferrin bound directly to both HS and CS isolated from surfaces of the studied cells, as well as to commercial preparations of GAG chains.	Chondroitin Sulfates	72-74	lactotransferrin	Bos taurus	30-41
14972565-6	2004	The results support the hypothesis that the inhibition of HSV-1 infectivity by lactoferrin is dependent on its interaction with cell surface GAG chains of HS and CS.	Chondroitin Sulfates	162-164	lactotransferrin	Bos taurus	79-90
15588226-0	2004	Human high molecular weight-melanoma-associated antigen (HMW-MAA): a melanoma cell surface chondroitin sulfate proteoglycan (MSCP) with biological and clinical significance.	Chondroitin Sulfates	91-110	chondroitin sulfate proteoglycan 4	Homo sapiens	6-55
14709897-8	2004	Levels of anti-type II collagen antibody and tumor necrosis factor-alpha (TNF-alpha) in sera were also reduced by LMWCS treatment but not in case of CS, although no significant difference was observed between LMWCS and CS on interleukin-6 (IL-6) induction.	Chondroitin Sulfates	117-119	tumor necrosis factor	Mus musculus	45-72
14709897-8	2004	Levels of anti-type II collagen antibody and tumor necrosis factor-alpha (TNF-alpha) in sera were also reduced by LMWCS treatment but not in case of CS, although no significant difference was observed between LMWCS and CS on interleukin-6 (IL-6) induction.	Chondroitin Sulfates	117-119	tumor necrosis factor	Mus musculus	74-83
14709897-8	2004	Levels of anti-type II collagen antibody and tumor necrosis factor-alpha (TNF-alpha) in sera were also reduced by LMWCS treatment but not in case of CS, although no significant difference was observed between LMWCS and CS on interleukin-6 (IL-6) induction.	Chondroitin Sulfates	117-119	interleukin 6	Mus musculus	225-238
14709897-8	2004	Levels of anti-type II collagen antibody and tumor necrosis factor-alpha (TNF-alpha) in sera were also reduced by LMWCS treatment but not in case of CS, although no significant difference was observed between LMWCS and CS on interleukin-6 (IL-6) induction.	Chondroitin Sulfates	117-119	interleukin 6	Mus musculus	240-244
14695326-2	2004	Impaired elastogenesis in these diseases associates with respective abnormal accumulation of chondroitin sulfate and dermatan sulfate proteoglycans that induce cell surface shedding of elastin-binding protein (EBP) normally required for intracellular chaperoning of tropoelastin and its assembly into elastic fibers.	Chondroitin Sulfates	93-112	EBP cholestenol delta-isomerase	Homo sapiens	185-208
14695326-2	2004	Impaired elastogenesis in these diseases associates with respective abnormal accumulation of chondroitin sulfate and dermatan sulfate proteoglycans that induce cell surface shedding of elastin-binding protein (EBP) normally required for intracellular chaperoning of tropoelastin and its assembly into elastic fibers.	Chondroitin Sulfates	93-112	EBP cholestenol delta-isomerase	Homo sapiens	210-213
14695326-2	2004	Impaired elastogenesis in these diseases associates with respective abnormal accumulation of chondroitin sulfate and dermatan sulfate proteoglycans that induce cell surface shedding of elastin-binding protein (EBP) normally required for intracellular chaperoning of tropoelastin and its assembly into elastic fibers.	Chondroitin Sulfates	93-112	elastin	Homo sapiens	266-278
14695326-3	2004	A variant of the chondroitin sulfate proteoglycan versican, V3, which lacks chondroitin sulfate, has recently been shown to stimulate elastic fiber assembly and decrease proliferation when expressed by retroviral transduction in arterial smooth muscle cells.	Chondroitin Sulfates	17-36	versican	Homo sapiens	50-58
14695326-3	2004	A variant of the chondroitin sulfate proteoglycan versican, V3, which lacks chondroitin sulfate, has recently been shown to stimulate elastic fiber assembly and decrease proliferation when expressed by retroviral transduction in arterial smooth muscle cells.	Chondroitin Sulfates	76-95	versican	Homo sapiens	50-58
15588226-0	2004	Human high molecular weight-melanoma-associated antigen (HMW-MAA): a melanoma cell surface chondroitin sulfate proteoglycan (MSCP) with biological and clinical significance.	Chondroitin Sulfates	91-110	chondroitin sulfate proteoglycan 4	Homo sapiens	57-64
15115911-1	2004	Neuroglycan C (NGC), a brain-specific transmembrane proteoglycan, is thought to bear not only chondroitin sulfate but also N- and O-linked oligosaccharides on its core protein.	Chondroitin Sulfates	94-113	chondroitin sulfate proteoglycan 5	Rattus norvegicus	0-13
15115911-1	2004	Neuroglycan C (NGC), a brain-specific transmembrane proteoglycan, is thought to bear not only chondroitin sulfate but also N- and O-linked oligosaccharides on its core protein.	Chondroitin Sulfates	94-113	chondroitin sulfate proteoglycan 5	Rattus norvegicus	15-18
15115911-3	2004	The chondroitin sulfate disaccharide composition of NGC at postnatal day 10 was significantly different from those of two secreted chondroitin sulfate proteoglycans, neurocan and phosphacan, purified from the brain at the same developmental stage; higher levels of 4-sulfate unit and E unit, a disulfated disaccharide unit, and a lower level of 6-sulfate unit.	Chondroitin Sulfates	4-23	chondroitin sulfate proteoglycan 5	Rattus norvegicus	52-55
15467399-4	2004	NGC is a novel part-time proteoglycan that changes its structure from a proteoglycan form to a non-proteoglycan form without chondroitin sulfate chains during the development of the cerebellum and retina.	Chondroitin Sulfates	125-144	chondroitin sulfate proteoglycan 5	Mus musculus	0-3
14661246-7	2004	The chondroitin sulfate hydrogels degraded specifically in the presence of the enzyme chondroitinase.	Chondroitin Sulfates	4-23	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	86-100
14697661-6	2003	In contrast to the core glycoprotein, the phosphacan chondroitin sulfate (CS) glycosaminoglycan epitope DSD-1 was up-regulated after 7 dpl.	Chondroitin Sulfates	53-72	protein tyrosine phosphatase receptor type Z1	Homo sapiens	42-52
15501589-5	2004	The expression of these molecules is localized differentially in the epileptogenic dentate gyrus, especially in the sprouting molecular layer, where a strong upregulation of phosphacan, tenascin-C, and HNK-1 is observed but there is no expression of the proteoglycan, neurocan, nor of the DSD-1 chondroitin sulfate motif.	Chondroitin Sulfates	295-314	tenascin C	Mus musculus	186-196
15153611-5	2004	IL-6R/IL-6 leads to an increase in early chondroitin sulfate proteoglycan positive and late O4 positive progenitors and to a stimulation of maturation into O1 and myelin basic protein expressing oligodendrocytes.	Chondroitin Sulfates	41-60	interleukin 6 receptor, alpha	Mus musculus	0-5
15153611-5	2004	IL-6R/IL-6 leads to an increase in early chondroitin sulfate proteoglycan positive and late O4 positive progenitors and to a stimulation of maturation into O1 and myelin basic protein expressing oligodendrocytes.	Chondroitin Sulfates	41-60	interleukin 6	Mus musculus	0-4
13679381-4	2003	We also show that IL-1alpha treatment reduces both total GAG and CS synthesis, decreases C6S:C4S ratios (less C6S), but fails to modify chondrocyte UDPGD activity at all ages.	Chondroitin Sulfates	65-67	interleukin 1 alpha	Homo sapiens	18-27
13679381-5	2003	On the other hand, TGF-beta1 increases total GAG synthesis in immature, but not mature, cartilage (stimulates CS but not non-CS), age-independently decreases C6S:C4S (more C4S), and increases chondrocyte UDPGD activity in a manner inversely correlated with age.	Chondroitin Sulfates	110-112	transforming growth factor beta 1	Homo sapiens	19-28
13679381-5	2003	On the other hand, TGF-beta1 increases total GAG synthesis in immature, but not mature, cartilage (stimulates CS but not non-CS), age-independently decreases C6S:C4S (more C4S), and increases chondrocyte UDPGD activity in a manner inversely correlated with age.	Chondroitin Sulfates	125-127	transforming growth factor beta 1	Homo sapiens	19-28
14647991-5	2004	Through a variable number of N-terminal epidermal growth factor (EGF)-like domains, EGF-TM7 receptors interact with cellular ligands such as CD55 and chondroitin sulfate.	Chondroitin Sulfates	150-169	epidermal growth factor	Homo sapiens	40-63
14583446-1	2003	Mucopolysaccharidosis IVA is an autosomal recessive disorder caused by a deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), a lysosomal enzyme required for the stepwise degradation of keratan sulfate (KS) and chondroitin-6-sulfate (C6S).	Chondroitin Sulfates	223-244	galactosamine (N-acetyl)-6-sulfate sulfatase	Mus musculus	130-135
14583446-1	2003	Mucopolysaccharidosis IVA is an autosomal recessive disorder caused by a deficiency of N-acetylgalactosamine-6-sulfate sulfatase (GALNS), a lysosomal enzyme required for the stepwise degradation of keratan sulfate (KS) and chondroitin-6-sulfate (C6S).	Chondroitin Sulfates	246-249	galactosamine (N-acetyl)-6-sulfate sulfatase	Mus musculus	130-135
14697661-9	2003	Examining the effects of phosphacan on axon growth from rat E17 cortical neurons, we found that phosphacan stimulates outgrowth in a largely CS dependent manner, while it blocks the outgrowth-promoting effects of laminin through an interaction that is not affected by removal of the CS chains.	Chondroitin Sulfates	283-285	protein tyrosine phosphatase receptor type Z1	Homo sapiens	96-106
14697661-6	2003	In contrast to the core glycoprotein, the phosphacan chondroitin sulfate (CS) glycosaminoglycan epitope DSD-1 was up-regulated after 7 dpl.	Chondroitin Sulfates	74-76	protein tyrosine phosphatase receptor type Z1	Homo sapiens	42-52
14697661-9	2003	Examining the effects of phosphacan on axon growth from rat E17 cortical neurons, we found that phosphacan stimulates outgrowth in a largely CS dependent manner, while it blocks the outgrowth-promoting effects of laminin through an interaction that is not affected by removal of the CS chains.	Chondroitin Sulfates	141-143	protein tyrosine phosphatase receptor type Z1	Homo sapiens	96-106
12947106-8	2003	These results demonstrate that the LG4/5 modules within unprocessed laminin-5 permit its cell binding activity through heparan and chondroitin sulfate chains of syndecan-1 and reinforce previous data suggesting specific properties for the precursor molecule.	Chondroitin Sulfates	131-150	syndecan 1	Homo sapiens	161-171
12973676-8	2003	It appears likely that in complex and mixed tumours versican exists in at least two forms, one of them lacking the CS attachment domain and the 2B1 epitope.	Chondroitin Sulfates	115-117	versican	Canis lupus familiaris	52-60
12933790-9	2003	The 175-kDa rHARE binds HA, dermatan sulfate, and chondroitin sulfates A, C, D, and E, but not chondroitin, heparin, heparan sulfate, or keratan sulfate.	Chondroitin Sulfates	50-70	stabilin 2	Rattus norvegicus	12-17
12834595-2	2003	In this study, isolated type I collagen fibrils, elastin fibres and chondroitin sulphate (CS) were used for the preparation of molecularly-defined collagen-elastin-glycosaminoglycan scaffolds.	Chondroitin Sulfates	68-88	elastin	Homo sapiens	156-163
14511383-3	2003	Testican-1 inhibition of cathepsin L is independent of its chondroitin sulfate chains and is effective at both pH 5.5 and 7.2.	Chondroitin Sulfates	59-78	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1	Homo sapiens	0-10
12917413-1	2003	Brain-specific chondroitin sulfate (CS) proteoglycan (PG) DSD-1-PG/6B4-PG/phosphacan isolated from neonatal mouse brains exhibits neurite outgrowth-promoting activity toward embryonic rat and mouse hippocampal neurons in vitro through the so-called DSD-1 epitope embedded in its glycosaminoglycan side chains.	Chondroitin Sulfates	15-34	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	58-66
12917413-1	2003	Brain-specific chondroitin sulfate (CS) proteoglycan (PG) DSD-1-PG/6B4-PG/phosphacan isolated from neonatal mouse brains exhibits neurite outgrowth-promoting activity toward embryonic rat and mouse hippocampal neurons in vitro through the so-called DSD-1 epitope embedded in its glycosaminoglycan side chains.	Chondroitin Sulfates	36-38	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	58-66
12917413-2	2003	Oversulfated CS variants, CS-D from shark cartilage and CS-E from squid cartilage, also possess similar activities.	Chondroitin Sulfates	13-15	cysteine sulfinic acid decarboxylase	Mus musculus	26-30
12917413-2	2003	Oversulfated CS variants, CS-D from shark cartilage and CS-E from squid cartilage, also possess similar activities.	Chondroitin Sulfates	13-15	cystathionase (cystathionine gamma-lyase)	Mus musculus	56-60
12917413-3	2003	We have proposed that the neuritogenic property of the DSD-1 epitope may be attributable to a distinct CS structure characterized by the disulfated D disaccharide unit [GlcUA(2S)-GalNAc(6S)].	Chondroitin Sulfates	103-105	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Mus musculus	179-188
12829604-6	2003	Through the use of mutant Chinese hamster ovary (CHO) cell lines defective in glycosaminoglycans (GAGs) biosynthesis as well as the enzymatic removal of specific cell surface GAGs, the molecular identity of the EMR2 ligand was identified as chondroitin sulfate (CS).	Chondroitin Sulfates	241-260	adhesion G protein-coupled receptor E2	Homo sapiens	211-215
12829604-6	2003	Through the use of mutant Chinese hamster ovary (CHO) cell lines defective in glycosaminoglycans (GAGs) biosynthesis as well as the enzymatic removal of specific cell surface GAGs, the molecular identity of the EMR2 ligand was identified as chondroitin sulfate (CS).	Chondroitin Sulfates	262-264	adhesion G protein-coupled receptor E2	Homo sapiens	211-215
12829604-7	2003	Thus, exogenous CS GAGs blocked the EMR2-ligand interaction in a dose-dependent manner.	Chondroitin Sulfates	16-18	adhesion G protein-coupled receptor E2	Homo sapiens	36-40
12829604-8	2003	EMR2-CS interaction is Ca2+- and sulphation-dependent and results in cell attachment.	Chondroitin Sulfates	5-7	adhesion G protein-coupled receptor E2	Homo sapiens	0-4
12874280-3	2003	We here present evidence that GalNAc4S-6ST should be involved in a unique nonreducing terminal modification of chondroitin sulfate A (CSA).	Chondroitin Sulfates	111-132	carbohydrate sulfotransferase 15	Homo sapiens	30-42
12874280-3	2003	We here present evidence that GalNAc4S-6ST should be involved in a unique nonreducing terminal modification of chondroitin sulfate A (CSA).	Chondroitin Sulfates	134-137	carbohydrate sulfotransferase 15	Homo sapiens	30-42
12920045-2	2003	To explore how glycosaminoglycan changes could influence the thrombogenicity of atherosclerotic lesions, water-transfer reactions were examined during activation of antithrombin by CS.	Chondroitin Sulfates	181-183	serpin family C member 1	Homo sapiens	165-177
12920045-5	2003	Oversulfated CS functionally bound antithrombin with a dissociation constant of 3.3+/-1.9 micromol/L.	Chondroitin Sulfates	13-15	serpin family C member 1	Homo sapiens	35-47
12834595-2	2003	In this study, isolated type I collagen fibrils, elastin fibres and chondroitin sulphate (CS) were used for the preparation of molecularly-defined collagen-elastin-glycosaminoglycan scaffolds.	Chondroitin Sulfates	90-92	elastin	Homo sapiens	156-163
12799382-1	2003	BEHAB (brain-enriched hyaluronan-binding protein)/brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult rat brain.	Chondroitin Sulfates	80-99	brevican	Rattus norvegicus	0-5
12969135-8	2003	Ion-exchange chromatography suggested that chondroitin sulfate/dermatan sulfate proteoglycans were up-regulated after HGF treatment.	Chondroitin Sulfates	43-62	hepatocyte growth factor	Rattus norvegicus	118-121
13680853-8	2003	Although the size of chondroitin sulfate chains is identical in both versican preparations, a significant increase in the percentage of 6-sulfated disaccharides is observed in chondroitin sulfate chains of versican in aneurysmal aortas, which is accompanied by decrease in 4-sulfated and non-sulfated units.	Chondroitin Sulfates	176-195	versican	Homo sapiens	206-214
12960244-3	2003	First, we examined binding of MPO to CS-Sepharose and measured an ionic interaction, which was disrupted by 200-400 mM NaCl.	Chondroitin Sulfates	37-39	myeloperoxidase	Homo sapiens	30-33
12960244-9	2003	Extracts from high buoyant density organelles from human placenta containing MPO activity were subjected to CS-affinity chromatography.	Chondroitin Sulfates	108-110	myeloperoxidase	Homo sapiens	77-80
12960244-10	2003	Proteins binding to CS were identified by mass spectrometry as MPO, lactoferrin, cathepsin G, and azurocidin/cationic antimicrobial protein of molecular weight 37 kDa, suggesting that serglycin may be a general transport vehicle for the cationic granular proteins of neutrophils.	Chondroitin Sulfates	20-22	myeloperoxidase	Homo sapiens	63-66
12960244-10	2003	Proteins binding to CS were identified by mass spectrometry as MPO, lactoferrin, cathepsin G, and azurocidin/cationic antimicrobial protein of molecular weight 37 kDa, suggesting that serglycin may be a general transport vehicle for the cationic granular proteins of neutrophils.	Chondroitin Sulfates	20-22	cathepsin G	Homo sapiens	81-92
12960244-10	2003	Proteins binding to CS were identified by mass spectrometry as MPO, lactoferrin, cathepsin G, and azurocidin/cationic antimicrobial protein of molecular weight 37 kDa, suggesting that serglycin may be a general transport vehicle for the cationic granular proteins of neutrophils.	Chondroitin Sulfates	20-22	azurocidin 1	Homo sapiens	98-108
12840014-0	2003	Heterogeneity of the chondroitin sulfate portion of phosphacan/6B4 proteoglycan regulates its binding affinity for pleiotrophin/heparin binding growth-associated molecule.	Chondroitin Sulfates	21-40	pleiotrophin	Rattus norvegicus	115-127
12840014-0	2003	Heterogeneity of the chondroitin sulfate portion of phosphacan/6B4 proteoglycan regulates its binding affinity for pleiotrophin/heparin binding growth-associated molecule.	Chondroitin Sulfates	21-40	pleiotrophin	Rattus norvegicus	128-170
12840014-1	2003	PTP zeta is a receptor-type protein-tyrosine phosphatase that is synthesized as a chondroitin sulfate proteoglycan and uses pleiotrophin as a ligand.	Chondroitin Sulfates	82-101	protein tyrosine phosphatase, receptor type Z1	Rattus norvegicus	0-8
12840014-2	2003	The chondroitin sulfate portion of this receptor is essential for high affinity binding to pleiotrophin.	Chondroitin Sulfates	4-23	pleiotrophin	Rattus norvegicus	91-103
12840014-5	2003	In particular, only PG-P20 reacted with the monoclonal antibody MO-225, which recognizes chondroitin sulfate containing the GlcA(2S)beta 1-3GalNAc(6S) disaccharide unit (D unit).	Chondroitin Sulfates	89-108	heat shock protein family B (small) member 6	Rattus norvegicus	23-26
12799382-1	2003	BEHAB (brain-enriched hyaluronan-binding protein)/brevican is the most abundant chondroitin sulfate proteoglycan in the extracellular matrix of the adult rat brain.	Chondroitin Sulfates	80-99	brevican	Rattus norvegicus	7-48
12873445-5	2003	A peak of synthesis of chondroitin sulfates is evident at around P14.	Chondroitin Sulfates	23-43	SUB1 regulator of transcription	Rattus norvegicus	65-68
12586630-10	2003	Instead, PF4 may modulate the hematopoietic milieu both directly, by promoting progenitor adhesion and quiescence through interaction with an HPC chondroitin sulfate-containing moiety, and indirectly, by binding to or interfering with signaling caused by other, hematopoietically active chemokines, such as IL-8.	Chondroitin Sulfates	146-165	platelet factor 4	Homo sapiens	9-12
12716890-1	2003	We recently cloned human chondroitin synthase (ChSy) exhibiting the glucuronyltransferase-II (GlcATII) and N-acetylgalactosaminyltransferase-II (GalNAcTII) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate, but chondroitin polymerization was not demonstrated in vitro using the recombinant ChSy.	Chondroitin Sulfates	235-254	chondroitin sulfate synthase 1	Homo sapiens	25-45
12716890-1	2003	We recently cloned human chondroitin synthase (ChSy) exhibiting the glucuronyltransferase-II (GlcATII) and N-acetylgalactosaminyltransferase-II (GalNAcTII) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate, but chondroitin polymerization was not demonstrated in vitro using the recombinant ChSy.	Chondroitin Sulfates	235-254	chondroitin sulfate synthase 1	Homo sapiens	47-51
12716890-1	2003	We recently cloned human chondroitin synthase (ChSy) exhibiting the glucuronyltransferase-II (GlcATII) and N-acetylgalactosaminyltransferase-II (GalNAcTII) activities responsible for the biosynthesis of repeating disaccharide units of chondroitin sulfate, but chondroitin polymerization was not demonstrated in vitro using the recombinant ChSy.	Chondroitin Sulfates	235-254	chondroitin sulfate synthase 1	Homo sapiens	107-143
12519080-4	2003	We previously described that the synthetic heparin-binding peptide/III5 (HBP/III5) (WTPPRAQITGYRLTVGLTRR, repeat III5) binds heparin and mediates cell adhesion via chondroitin sulphate proteoglycans.	Chondroitin Sulfates	164-184	heme binding protein 1	Homo sapiens	73-81
12796199-4	2003	Arylsulfatase B, also known as N-acetyl galactosamine 4-sulfatase, can degrade DS and chondroitin-4 sulfate.	Chondroitin Sulfates	86-107	arylsulfatase B	Homo sapiens	0-15
12796199-4	2003	Arylsulfatase B, also known as N-acetyl galactosamine 4-sulfatase, can degrade DS and chondroitin-4 sulfate.	Chondroitin Sulfates	86-107	arylsulfatase B	Homo sapiens	31-65
12736501-0	2003	The effect of chondroitin sulfate against CCl4-induced hepatotoxicity.	Chondroitin Sulfates	14-33	C-C motif chemokine ligand 4	Rattus norvegicus	42-46
12709053-8	2003	In addition, SPR established that solution-phase PAI-1/VN complexes and non-native VN (extracellular matrix form) bind TM directly via the chondroitin sulphate moiety of TM.	Chondroitin Sulfates	139-159	serpin family E member 1	Homo sapiens	49-54
12709053-8	2003	In addition, SPR established that solution-phase PAI-1/VN complexes and non-native VN (extracellular matrix form) bind TM directly via the chondroitin sulphate moiety of TM.	Chondroitin Sulfates	139-159	vitronectin	Homo sapiens	55-57
12709053-8	2003	In addition, SPR established that solution-phase PAI-1/VN complexes and non-native VN (extracellular matrix form) bind TM directly via the chondroitin sulphate moiety of TM.	Chondroitin Sulfates	139-159	vitronectin	Homo sapiens	83-85
12709053-8	2003	In addition, SPR established that solution-phase PAI-1/VN complexes and non-native VN (extracellular matrix form) bind TM directly via the chondroitin sulphate moiety of TM.	Chondroitin Sulfates	139-159	thrombomodulin	Homo sapiens	119-121
12709053-8	2003	In addition, SPR established that solution-phase PAI-1/VN complexes and non-native VN (extracellular matrix form) bind TM directly via the chondroitin sulphate moiety of TM.	Chondroitin Sulfates	139-159	thrombomodulin	Homo sapiens	170-172
12626425-1	2003	The clearance of hyaluronan (HA) and chondroitin sulfates from the circulating blood and lymph in the body is mediated by the membrane-bound HA receptor for endocytosis (HARE).	Chondroitin Sulfates	37-57	stabilin 2	Homo sapiens	170-174
12684467-1	2003	PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding.	Chondroitin Sulfates	80-99	protein tyrosine phosphatase receptor type Z1	Homo sapiens	0-7
12654635-0	2003	Binding of interleukin-8 to heparan sulfate and chondroitin sulfate in lung tissue.	Chondroitin Sulfates	48-67	C-X-C motif chemokine ligand 8	Homo sapiens	11-24
12654635-5	2003	Confocal microscopy demonstrated IL-8 binding to specific anatomic locations such as cell surfaces and extracellular matrix that were enriched with heparan sulfate and chondroitin sulfate.	Chondroitin Sulfates	168-187	C-X-C motif chemokine ligand 8	Homo sapiens	33-37
12654635-6	2003	Removal of heparan sulfate or chondroitin sulfate from lung tissue significantly decreased the binding of 125I-IL-8.	Chondroitin Sulfates	30-49	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
12684467-1	2003	PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding.	Chondroitin Sulfates	80-99	protein tyrosine phosphatase receptor type Z1	Homo sapiens	8-16
12684467-1	2003	PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding.	Chondroitin Sulfates	80-99	pleiotrophin	Homo sapiens	156-168
12684467-1	2003	PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding.	Chondroitin Sulfates	80-99	pleiotrophin	Homo sapiens	170-173
12684467-1	2003	PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding.	Chondroitin Sulfates	101-103	protein tyrosine phosphatase receptor type Z1	Homo sapiens	0-7
12684467-1	2003	PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding.	Chondroitin Sulfates	101-103	protein tyrosine phosphatase receptor type Z1	Homo sapiens	8-16
12684467-1	2003	PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding.	Chondroitin Sulfates	101-103	pleiotrophin	Homo sapiens	156-168
12684467-1	2003	PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding.	Chondroitin Sulfates	101-103	pleiotrophin	Homo sapiens	170-173
12684467-1	2003	PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding.	Chondroitin Sulfates	201-203	protein tyrosine phosphatase receptor type Z1	Homo sapiens	0-7
12684467-1	2003	PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding.	Chondroitin Sulfates	201-203	protein tyrosine phosphatase receptor type Z1	Homo sapiens	8-16
12684467-1	2003	PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding.	Chondroitin Sulfates	201-203	pleiotrophin	Homo sapiens	156-168
12684467-1	2003	PTPzeta/RPTPbeta, a receptor-type protein tyrosine phosphatase synthesized as a chondroitin sulfate (CS) proteoglycan, uses a heparin-binding growth factor pleiotrophin (PTN) as a ligand, in which the CS portion plays an essential role in ligand binding.	Chondroitin Sulfates	201-203	pleiotrophin	Homo sapiens	170-173
12684467-3	2003	An aberrant morphology of Purkinje cell dendrites such as multiple and disoriented primary dendrites was induced in slice cultures by (1) addition of a polyclonal antibody against the extracellular domain of PTPzeta, (2) inhibition of protein tyrosine phosphatase activity, (3) enzymatic removal of the CS chains, (4) addition of exogenous CS chains, and (5) addition of exogenous PTN, all of which disturb PTN-PTPzeta signaling.	Chondroitin Sulfates	303-305	protein tyrosine phosphatase receptor type Z1	Homo sapiens	208-215
12684467-3	2003	An aberrant morphology of Purkinje cell dendrites such as multiple and disoriented primary dendrites was induced in slice cultures by (1) addition of a polyclonal antibody against the extracellular domain of PTPzeta, (2) inhibition of protein tyrosine phosphatase activity, (3) enzymatic removal of the CS chains, (4) addition of exogenous CS chains, and (5) addition of exogenous PTN, all of which disturb PTN-PTPzeta signaling.	Chondroitin Sulfates	340-342	protein tyrosine phosphatase receptor type Z1	Homo sapiens	208-215
12645574-1	2003	Hyaluronan (HA) and chondroitin sulfate clearance from lymph and blood is mediated by the hyaluronan receptor for endocytosis (HARE).	Chondroitin Sulfates	20-39	stabilin 2	Rattus norvegicus	90-125
12645574-1	2003	Hyaluronan (HA) and chondroitin sulfate clearance from lymph and blood is mediated by the hyaluronan receptor for endocytosis (HARE).	Chondroitin Sulfates	20-39	stabilin 2	Rattus norvegicus	127-131
12444086-3	2003	Here, we report that a monoclonal antibody against chondroitin sulfate-binding proteins from neonatal rat brain recognizes collapsin response mediator protein-4 (CRMP-4), which belongs to a family of proteins involved in collapsin/semaphorin 3A signaling.	Chondroitin Sulfates	51-70	dihydropyrimidinase-like 3	Rattus norvegicus	123-160
12590599-15	2003	In addition, we show that oversulfation of heparan sulfate produced by cells tranfected with wild-type NDST-1 or the mutant lacking N-sulfotranferase activity results in decreased sulfation of chondroitin sulfate.	Chondroitin Sulfates	193-212	N-deacetylase and N-sulfotransferase 1	Homo sapiens	103-109
12522561-1	2003	Mucopolysaccharidosis VII (MPS VII) is an autosomal recessive disorder caused by the deficiency of beta-glucuronidase leading to the intralysosomal storage of heparan, dermatan, and chondroitin sulfate.	Chondroitin Sulfates	182-201	glucuronidase beta	Homo sapiens	99-117
12444086-3	2003	Here, we report that a monoclonal antibody against chondroitin sulfate-binding proteins from neonatal rat brain recognizes collapsin response mediator protein-4 (CRMP-4), which belongs to a family of proteins involved in collapsin/semaphorin 3A signaling.	Chondroitin Sulfates	51-70	dihydropyrimidinase-like 3	Rattus norvegicus	162-168
12444086-3	2003	Here, we report that a monoclonal antibody against chondroitin sulfate-binding proteins from neonatal rat brain recognizes collapsin response mediator protein-4 (CRMP-4), which belongs to a family of proteins involved in collapsin/semaphorin 3A signaling.	Chondroitin Sulfates	51-70	semaphorin 3A	Rattus norvegicus	231-244
12446672-6	2003	Transfection of the CSGalNAcT-1 gene into Chinese hamster ovary cells yielded a change of glycosaminoglycan composition, i.e. the replacement of heparan sulfate on a syndecan-4/fibroblast growth factor-1 chimera protein by chondroitin sulfate, however, transfection of the CSGalNAcT-2 gene did not.	Chondroitin Sulfates	223-242	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Cricetulus griseus	20-31
12446672-7	2003	The above results indicated that CSGalNAcT-1 is involved in the initiation of chondroitin sulfate synthesis, whereas CSGalNAcT-2 participates mainly in the elongation, not initiation.	Chondroitin Sulfates	78-97	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Cricetulus griseus	33-44
14515153-3	2003	Bikunin, which has antiproteolytic activity, carries a chondroitin sulphate chain to which the heavy chains are covalently linked.	Chondroitin Sulfates	55-75	alpha-1-microglobulin/bikunin precursor	Homo sapiens	0-7
12552432-1	2003	Plasmodium falciparum placental parasites from Cameroon have been shown to express surface variant var genes encoding Duffy binding-like (DBL)-gamma domains that bind chondroitin sulfate A.	Chondroitin Sulfates	167-188	MCF.2 cell line derived transforming sequence	Homo sapiens	138-141
12495930-4	2003	cDNA microarray analysis showed organ-specific upregulation of the retinoic acid responsive gene midkine (MK) and its chondroitin-sulfate binding partner PG-M/versican at fetal day 18 and at neonatal day 1 in lungs of GR(hypo) mice, and at neonatal day 1 in lungs of GR(null) mice.	Chondroitin Sulfates	118-137	midkine	Mus musculus	97-104
12765780-7	2003	268 (2001) 2717), we provided evidence that, during acute phase response, the GAG chain of Bk, which is a low-sulphated chondroitin-sulphate, increases in size according to the severity of the inflammatory disease.	Chondroitin Sulfates	120-140	alpha-1-microglobulin/bikunin precursor	Homo sapiens	91-93
12634322-1	2003	Midkine (MK), a heparin-binding growth factor, binds strongly to oversulfated structures in chondroitin sulfates (CSs) and heparan sulfate.	Chondroitin Sulfates	92-112	midkine	Homo sapiens	0-7
12634322-1	2003	Midkine (MK), a heparin-binding growth factor, binds strongly to oversulfated structures in chondroitin sulfates (CSs) and heparan sulfate.	Chondroitin Sulfates	92-112	midkine	Homo sapiens	9-11
15000815-1	2003	Mucopolysaccharidosis type VI, or Maroteaux-Lamy syndrome, is an autosomal recessive disease caused by the deficiency of arylsulfatase B (ARSB; N-acetyl-galactosamine-4-sulfatase, E.C.3.1.6.12), which is involved in the stepwise degradation of dermatan sulfate and chondroitin sulfate.	Chondroitin Sulfates	265-284	arylsulfatase B	Homo sapiens	138-142
12634322-1	2003	Midkine (MK), a heparin-binding growth factor, binds strongly to oversulfated structures in chondroitin sulfates (CSs) and heparan sulfate.	Chondroitin Sulfates	114-117	midkine	Homo sapiens	0-7
12634322-1	2003	Midkine (MK), a heparin-binding growth factor, binds strongly to oversulfated structures in chondroitin sulfates (CSs) and heparan sulfate.	Chondroitin Sulfates	114-117	midkine	Homo sapiens	9-11
15000815-1	2003	Mucopolysaccharidosis type VI, or Maroteaux-Lamy syndrome, is an autosomal recessive disease caused by the deficiency of arylsulfatase B (ARSB; N-acetyl-galactosamine-4-sulfatase, E.C.3.1.6.12), which is involved in the stepwise degradation of dermatan sulfate and chondroitin sulfate.	Chondroitin Sulfates	265-284	arylsulfatase B	Homo sapiens	144-178
12413739-0	2002	Effect of chondroitin sulfate on murine splenocytes sensitized with ovalbumin.	Chondroitin Sulfates	10-29	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	68-77
12407110-1	2002	Previous studies have demonstrated that CD44 isoforms containing the alternatively spliced exon v10 promote cell-cell adhesion via a mechanism that involves the recognition of chondroitin sulfate side chains presented on the surface of interacting cells in association with other CD44 molecules.	Chondroitin Sulfates	176-195	CD44 molecule (Indian blood group)	Homo sapiens	40-44
12413739-3	2002	CS induced secretion of Th1-type cytokines (IFN-gamma, IL-2, and IL-12) by OVA-sensitized splenocytes but suppressed secretion of Th2-type cytokines (IL-5 and IL-10).	Chondroitin Sulfates	0-2	interferon gamma	Mus musculus	44-53
12413739-3	2002	CS induced secretion of Th1-type cytokines (IFN-gamma, IL-2, and IL-12) by OVA-sensitized splenocytes but suppressed secretion of Th2-type cytokines (IL-5 and IL-10).	Chondroitin Sulfates	0-2	interleukin 2	Mus musculus	55-59
12413739-3	2002	CS induced secretion of Th1-type cytokines (IFN-gamma, IL-2, and IL-12) by OVA-sensitized splenocytes but suppressed secretion of Th2-type cytokines (IL-5 and IL-10).	Chondroitin Sulfates	0-2	interleukin 5	Mus musculus	150-154
12413739-3	2002	CS induced secretion of Th1-type cytokines (IFN-gamma, IL-2, and IL-12) by OVA-sensitized splenocytes but suppressed secretion of Th2-type cytokines (IL-5 and IL-10).	Chondroitin Sulfates	0-2	interleukin 10	Mus musculus	159-164
12413739-5	2002	Analysis of the IFN-gamma mRNA level of the splenocytes by the real-time quantitative RT-PCR technique revealed higher levels in the splenocytes cultured with OVA and CS than in the splenocytes cultured with OVA alone.	Chondroitin Sulfates	167-169	interferon gamma	Mus musculus	16-25
12442278-2	2002	The deficiency of N-acetylgalactosamine-6-sulfate sulfatase leads to lysosomal accumulation of undegraded glycosaminoglycans, keratan sulfate and chondroitin-6-sulfate.	Chondroitin Sulfates	146-167	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	18-59
12186633-2	2002	We found that recombinant human PrP (rPrP) binds GAGs including chondroitin sulphate A, chondroitin sulphate B, hyaluronic acid, and heparin.	Chondroitin Sulfates	64-86	prion protein	Homo sapiens	32-35
12186633-2	2002	We found that recombinant human PrP (rPrP) binds GAGs including chondroitin sulphate A, chondroitin sulphate B, hyaluronic acid, and heparin.	Chondroitin Sulfates	64-86	prion protein	Rattus norvegicus	37-41
12207034-1	2002	Chondroitin sulfate and dermatan sulfate proteoglycans are distinguished by differences in their proportion of d-glucuronosyl and l-iduronosyl residues, the latter being formed by chondroitin-glucuronate 5-epimerase during or after glycosaminoglycan chain polymerization.	Chondroitin Sulfates	0-19	dermatan sulfate epimerase	Homo sapiens	180-215
12221095-2	2002	We previously observed that the cortical neuronal cell adhesion mediated by midkine (MK), a heparin (Hep)-binding growth factor, is specifically inhibited by oversulfated chondroitin sulfate-E (CS-E) (Ueoka, C., Kaneda, N., Okazaki, I., Nadanaka, S., Muramatsu, T., and Sugahara, K. (2000) J. Biol.	Chondroitin Sulfates	171-190	midkine	Rattus norvegicus	76-83
12221095-2	2002	We previously observed that the cortical neuronal cell adhesion mediated by midkine (MK), a heparin (Hep)-binding growth factor, is specifically inhibited by oversulfated chondroitin sulfate-E (CS-E) (Ueoka, C., Kaneda, N., Okazaki, I., Nadanaka, S., Muramatsu, T., and Sugahara, K. (2000) J. Biol.	Chondroitin Sulfates	171-190	midkine	Rattus norvegicus	85-87
12115453-8	2002	CS reduced the release of VEGF, IL-6, and MMP-2, although it had no significant effect on the release of NO and MMP-9.	Chondroitin Sulfates	0-2	vascular endothelial growth factor A	Homo sapiens	26-30
12244074-6	2002	In the SR91 myeloid cell line, the majority of CD44 sulfation was attributed to the glycosaminoglycan chondroitin sulfate.	Chondroitin Sulfates	102-121	CD44 molecule (Indian blood group)	Homo sapiens	47-51
12244074-8	2002	Therefore, TNF-alpha induced a decrease in the percentage of CD44 sulfation due to chondroitin sulfate and an increase due to N- and O-linked sulfation.	Chondroitin Sulfates	83-102	tumor necrosis factor	Homo sapiens	11-20
12244074-8	2002	Therefore, TNF-alpha induced a decrease in the percentage of CD44 sulfation due to chondroitin sulfate and an increase due to N- and O-linked sulfation.	Chondroitin Sulfates	83-102	CD44 molecule (Indian blood group)	Homo sapiens	61-65
12115453-8	2002	CS reduced the release of VEGF, IL-6, and MMP-2, although it had no significant effect on the release of NO and MMP-9.	Chondroitin Sulfates	0-2	interleukin 6	Homo sapiens	32-36
12115453-8	2002	CS reduced the release of VEGF, IL-6, and MMP-2, although it had no significant effect on the release of NO and MMP-9.	Chondroitin Sulfates	0-2	matrix metallopeptidase 2	Homo sapiens	42-47
12375391-5	2002	The chondroitin sulfates ACS4-ACS6 may intervene not only in radiological progression but also in articular metabolism.	Chondroitin Sulfates	4-24	acyl-CoA synthetase long chain family member 4	Homo sapiens	25-29
12375394-0	2002	[A new mechanism of action of chondroitin sulfates ACS4-ACS6 in osteoarthritic cartilage].	Chondroitin Sulfates	30-50	acyl-CoA synthetase long chain family member 4	Homo sapiens	51-55
12405691-15	2002	The combination of GLN/CS decreased MMP-9 gelatinolytic activity but had no effect on MMP-2 activity.	Chondroitin Sulfates	23-25	matrix metallopeptidase 9	Equus caballus	36-41
12375394-1	2002	THE MECHANISMS OF ACTION ALREADY KNOWN: In vitro, chondroitin sulfate ACS4-ACS6 have a dose-dependent inhibiting effect on the catabolism of proteoglycanes and collagen.	Chondroitin Sulfates	50-69	acyl-CoA synthetase long chain family member 4	Homo sapiens	70-74
12375395-1	2002	Chondro-protective effect of chondroitin sulfates ACS4-ACS6].	Chondroitin Sulfates	29-49	acyl-CoA synthetase long chain family member 4	Homo sapiens	50-54
12372026-9	2002	Furthermore, the conditioned medium of the Chinese hamster ovary cells over-expressing APLP2-751 (chondroitin sulphate-modified), but not APLP2-763 (nonchondroitin sulphate-modified), was able to increase the number of the tyrosine hydroxylase-positive neurons in fetal mesencephalic cultures.	Chondroitin Sulfates	98-118	amyloid-like protein 2	Cricetulus griseus	87-92
12372026-11	2002	They also support the view that chondroitin sulphate-modified APLP2 protein may play an important role in the dopaminergic nigrostriatal system.	Chondroitin Sulfates	32-52	amyloid beta precursor like protein 2	Rattus norvegicus	62-67
12204104-6	2002	MK binds to the chondroitin sulfate portion of PTPzeta with high affinity.	Chondroitin Sulfates	16-35	protein tyrosine phosphatase receptor type Z1	Homo sapiens	47-54
12034737-5	2002	In some cell lines, CXCR4 is efficiently modified by a chondroitin sulfate chain at serine 18, but neither HIV-1 entry nor stromal derived factor 1 alpha binding was affected by loss of this glycosaminoglycan.	Chondroitin Sulfates	55-74	C-X-C motif chemokine receptor 4	Homo sapiens	20-25
12149234-2	2002	Recently it was shown that IE sequestration in the placenta is mediated by binding to chondroitin sulfate A via the duffy binding-like (DBL)-gamma 3 domain of P falciparum erythrocyte membrane protein 1 (PfEMP1(CSA)).	Chondroitin Sulfates	86-107	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	211-214
12039963-0	2002	Collagenase activity of cathepsin K depends on complex formation with chondroitin sulfate.	Chondroitin Sulfates	70-89	cathepsin K	Homo sapiens	24-35
12140262-0	2002	Annexin 6 is a putative cell surface receptor for chondroitin sulfate chains.	Chondroitin Sulfates	50-69	annexin A6	Homo sapiens	0-9
12140262-0	2002	Annexin 6 is a putative cell surface receptor for chondroitin sulfate chains.	Chondroitin Sulfates	50-69	CD177 molecule	Homo sapiens	24-45
12140262-9	2002	We confirmed that A431 cells were unable to attach to the chondroitin sulfate substratum and that the stable transfectants expressing annexin 6 conferred the ability to attach to chondroitin sulfate chains.	Chondroitin Sulfates	179-198	annexin A6	Homo sapiens	134-143
12140262-11	2002	In summary, annexin 6 is a candidate receptor for chondroitin sulfate chains.	Chondroitin Sulfates	50-69	annexin A6	Homo sapiens	12-21
12039963-4	2002	Here, we report a cathepsin K-specific complex with chondroitin sulfate, which is essential for the collagenolytic activity of the enzyme.	Chondroitin Sulfates	52-71	cathepsin K	Homo sapiens	18-29
12039963-7	2002	The primary substrate specificity of cathepsin K is not altered by complex formation, suggesting that the protease-chondroitin sulfate complex primarily facilitates the destabilization and/or the specific binding of the triple helical collagen structure.	Chondroitin Sulfates	115-134	cathepsin K	Homo sapiens	37-48
12039963-9	2002	The physiological relevance of cathepsin K complexes is supported by the findings that (i) the content of chondroitin sulfate present in bone and accessible to cathepsin K activity is sufficient for complex formation and (ii) Y212C, a cathepsin K mutant that causes pycnodysostosis (a bone sclerosing disorder) and that has no collagenase activity but remains potent as a gelatinase, is unable to form complexes.	Chondroitin Sulfates	106-125	cathepsin K	Homo sapiens	31-42
12039963-9	2002	The physiological relevance of cathepsin K complexes is supported by the findings that (i) the content of chondroitin sulfate present in bone and accessible to cathepsin K activity is sufficient for complex formation and (ii) Y212C, a cathepsin K mutant that causes pycnodysostosis (a bone sclerosing disorder) and that has no collagenase activity but remains potent as a gelatinase, is unable to form complexes.	Chondroitin Sulfates	106-125	cathepsin K	Homo sapiens	160-171
12039963-9	2002	The physiological relevance of cathepsin K complexes is supported by the findings that (i) the content of chondroitin sulfate present in bone and accessible to cathepsin K activity is sufficient for complex formation and (ii) Y212C, a cathepsin K mutant that causes pycnodysostosis (a bone sclerosing disorder) and that has no collagenase activity but remains potent as a gelatinase, is unable to form complexes.	Chondroitin Sulfates	106-125	cathepsin K	Homo sapiens	160-171
12118914-0	2002	Early onset of chondroitin sulfate and osteopontin expression in angiotensin II-dependent left ventricular hypertrophy.	Chondroitin Sulfates	15-34	angiotensinogen	Rattus norvegicus	65-79
11950836-1	2002	Beta1,3-glucuronyltransferase (GlcAT-I) is an essential enzyme involved in heparan sulfate and chondroitin sulfate biosynthesis.	Chondroitin Sulfates	95-114	beta-1,3-glucuronyltransferase 3	Homo sapiens	31-38
12096065-8	2002	SLP bound more strongly to heparin itself, and this binding was inhibited by glucuronic acid and chondroitin sulfate.	Chondroitin Sulfates	97-116	septin 9	Rattus norvegicus	0-3
12060613-8	2002	The decorin component of tumor stroma was previously shown to contain high levels of chondroitin sulfate as opposed to dermatan sulfate side chains, and those molecules contained unusually high levels of O- and 6-sulfate linkages.	Chondroitin Sulfates	85-104	decorin	Homo sapiens	4-11
12100556-3	2002	For example, a specific phenotypic switch in adhesion from CD36 to chondroitin sulphate A (CSA) is associated with malaria pathogenesis in pregnant women.	Chondroitin Sulfates	67-89	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	91-94
12094292-5	2002	The inhibitory activity of Na-SP was the strongest when compared to that of heparan sulfate, heparin, dextran sulfate, dermatan sulfate, chondroitin sulfate A/C and hyaluronan.	Chondroitin Sulfates	137-158	nuclear autoantigenic sperm protein	Bos taurus	27-32
11986215-5	2002	Inhibition of internalization and degradation by PF4 required the presence of cell-associated proteoglycans, primarily those rich in chondroitin sulfate.	Chondroitin Sulfates	133-152	platelet factor 4	Homo sapiens	49-52
12108544-3	2002	Here we show that NDST-2+/+ bone marrow-derived mast cells cultured in the presence of IL-3 synthesise, in addition to highly sulphated chondroitin sulphate (CS), small amounts of equally highly sulphated heparin-like polysaccharide.	Chondroitin Sulfates	136-156	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	18-24
12108544-3	2002	Here we show that NDST-2+/+ bone marrow-derived mast cells cultured in the presence of IL-3 synthesise, in addition to highly sulphated chondroitin sulphate (CS), small amounts of equally highly sulphated heparin-like polysaccharide.	Chondroitin Sulfates	158-160	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	18-24
12108544-4	2002	The corresponding NDST-2-/- cells produced highly sulphated CS only.	Chondroitin Sulfates	60-62	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	18-24
11956326-7	2002	We conclude that hypoxia increases endothelial cell responsiveness to FGF2 by promoting preferential synthesis of HS rather than CS chains and increasing the number of FGF2-binding sites on HS chains.	Chondroitin Sulfates	129-131	fibroblast growth factor 2	Homo sapiens	70-74
11909863-8	2002	Perlecan contained 25% heparan sulfate and 75% chondroitin sulfate.	Chondroitin Sulfates	47-66	heparan sulfate proteoglycan 2	Bos taurus	0-8
11939792-1	2002	The lysosomal hydrolase N-acetylgalactosamine 4-sulfatase (4-sulfatase) is required for the degradation of the glycosaminoglycan substrates dermatan and chondroitin sulfate.	Chondroitin Sulfates	153-172	arylsulfatase B	Homo sapiens	24-57
11991744-3	2002	Cell attachment of the VLP is efficiently inhibited by soluble heparin and dextran sulfate and less efficiently abrogated by several other glycosaminoglycans (GAGs) including chondroitin sulfate A and chondroitin sulfate B (dermatan sulfate), as determined by deconvolution microscopic immunodetection of the viral gag protein and by quantitative binding studies of metabolically labeled (35)S-VLP.	Chondroitin Sulfates	175-196	VHL like	Homo sapiens	23-26
11723110-5	2002	The cell surface binding of MRP-14 was blocked by heparin, heparan sulfate, and chondroitin sulfate B, and the binding sites were sensitive to heparinase I and trypsin treatment but not to chondroitinase ABC.	Chondroitin Sulfates	80-99	S100 calcium binding protein A9	Homo sapiens	28-34
11805102-3	2002	In pull-down assays and immunoprecipitation, beta(1)-integrin bound to the C-terminal domain of PG-M/versican, an extracellular chondroitin sulfate proteoglycan.	Chondroitin Sulfates	128-147	integrin subunit beta 1	Homo sapiens	45-61
11805102-3	2002	In pull-down assays and immunoprecipitation, beta(1)-integrin bound to the C-terminal domain of PG-M/versican, an extracellular chondroitin sulfate proteoglycan.	Chondroitin Sulfates	128-147	versican	Homo sapiens	101-109
11985664-4	2002	Enzymatic characterization of the ligand by trypsin, O-sialoglycoprotease endopeptidase, heparinases I and III, or chondroitinase ABC lyase digestion indicated that L-selectin binding was predominantly dependent upon a chondroitin sulphate-modified glycoprotein determinant.	Chondroitin Sulfates	219-239	selectin L	Homo sapiens	165-175
12009333-4	2002	Additionally, we have shown that MMPs were responsible for C-terminal catabolism of aggrecan and generation of chondroitin sulfate (CS) deficient aggrecan monomers and that this aggrecan truncation occurred prior to detectable IGD cleavage by MMPs.	Chondroitin Sulfates	111-130	matrix metallopeptidase 1	Homo sapiens	33-37
12009333-4	2002	Additionally, we have shown that MMPs were responsible for C-terminal catabolism of aggrecan and generation of chondroitin sulfate (CS) deficient aggrecan monomers and that this aggrecan truncation occurred prior to detectable IGD cleavage by MMPs.	Chondroitin Sulfates	132-134	matrix metallopeptidase 1	Homo sapiens	33-37
12009333-6	2002	Recombinant MMP-1, -3 and -13 were all capable of C-terminally truncating aggrecan with at least two cleavage sites N-terminal to the CS attachment domains of aggrecan.	Chondroitin Sulfates	134-136	matrix metallopeptidase 1	Homo sapiens	12-29
11898616-4	2002	Various alleles of this gene provide attachment of different number of chondroitin sulfate chains to a proteoglycan core protein, thereby changing functional properties of cartilage.	Chondroitin Sulfates	71-90	decorin	Homo sapiens	103-128
11788461-2	2002	Transforming growth factor (TGF)-beta1 has been identified in atherosclerotic vessels and has been shown to stimulate the synthesis of chondroitin sulfate- and dermatan sulfate-containing proteoglycans by arterial smooth muscle cells (ASMCs), but whether it promotes lipid retention has not been addressed.	Chondroitin Sulfates	135-154	transforming growth factor beta 1	Homo sapiens	0-38
11842937-13	2002	In conclusion, IL-4 stimulated accumulation of CS/HSPGs in human gingival fibroblasts.	Chondroitin Sulfates	47-49	interleukin 4	Homo sapiens	15-19
11696535-0	2002	Functional analysis of the chondroitin 6-sulfotransferase gene in relation to lymphocyte subpopulations, brain development, and oversulfated chondroitin sulfates.	Chondroitin Sulfates	141-161	carbohydrate sulfotransferase 3	Mus musculus	27-57
11696535-4	2002	In the spleen of C6st(-/-) mice, the level of chondroitin 6-sulfate became almost undetectable.	Chondroitin Sulfates	46-67	carbohydrate sulfotransferase 3	Mus musculus	17-21
11779146-1	2002	Syndecan-1 is an integral membrane heparan sulfate/chondroitin sulfate proteoglycan, involved in the control of cell growth and differentiation.	Chondroitin Sulfates	51-70	syndecan 1	Mus musculus	0-10
12489154-4	2002	GALNS cleaves the sulfate group from N-acetylgalactosamine 6-sulfate and galactose 6-sulfate, which are specifically found in keratan sulfate and chondroitin 6-sulfate.	Chondroitin Sulfates	146-167	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	0-5
12489154-10	2002	We conclude that enamel defects associated with the loss of GALNS activity in persons with MPS IVA are likely to result from the pathological accumulation of keratan sulfate and chondroitin 6-sulfate in the lysosomes of secretory stage ameloblasts.	Chondroitin Sulfates	178-199	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	60-65
12578541-3	2003	Here we report the development of a stable cell line, termed DB1, that was generated by transfecting cDNA encoding full-length human CTGF into Chinese hamster ovary cells that were mutant for heparin sulphate and chondroitin sulphate.	Chondroitin Sulfates	213-233	vascular endothelial zinc finger 1	Homo sapiens	61-64
11841687-0	2002	Hyaluronic acid and chondroitin sulphate A rapidly promote differentiation of immature DC with upregulation of costimulatory and antigen-presenting molecules, and enhancement of NF-kappaB and protein kinase activity.	Chondroitin Sulfates	20-40	nuclear factor kappa B subunit 1	Homo sapiens	178-187
11551958-7	2001	This product, Galbeta1,3Galbeta is found in the linkage region of heparan sulfate and chondroitin sulfate (GlcAbeta1,3Galbeta1,3Galbeta1,4Xylbeta-O-Ser), indicating that beta3GalT6 is the so-called galactosyltransferase II involved in glycosaminoglycan biosynthesis.	Chondroitin Sulfates	86-105	beta-1,3-galactosyltransferase 6	Homo sapiens	170-180
11551958-7	2001	This product, Galbeta1,3Galbeta is found in the linkage region of heparan sulfate and chondroitin sulfate (GlcAbeta1,3Galbeta1,3Galbeta1,4Xylbeta-O-Ser), indicating that beta3GalT6 is the so-called galactosyltransferase II involved in glycosaminoglycan biosynthesis.	Chondroitin Sulfates	86-105	beta-1,3-galactosyltransferase 6	Homo sapiens	198-222
11590178-0	2001	Endocan is a novel chondroitin sulfate/dermatan sulfate proteoglycan that promotes hepatocyte growth factor/scatter factor mitogenic activity.	Chondroitin Sulfates	19-38	endothelial cell specific molecule 1	Homo sapiens	0-7
11814316-9	2002	The digestion of chondroitin sulphate significantly improved the labelling for tenascin when a co-expression of these two molecules was present.	Chondroitin Sulfates	17-37	tenascin C	Canis lupus familiaris	79-87
11748689-1	2001	Human leukemic cell lines, Jurkat (T-cell leukemia), Daudi (Burkitt"s lymphoma, B-cell leukemia) and THP-1 (acute monocytic leukemia) synthesize chondroitin sulphate (CS) and heparan sulphate (HS) in both cell membrane and culture medium.	Chondroitin Sulfates	145-165	GLI family zinc finger 2	Homo sapiens	101-106
11791576-1	2001	Chondroitin sulfate (CS) is a glycosaminoglycan consisting of repeating uronic acid, N-acetylgalactosamine sulfate disaccharide units [-UroA(beta1,3)-GalNAcS(beta1,4)]n. Chondroitin sulfate type A (CSA) contains glucuronic acid, and 90% of the GalNAc residues are sulfated at the 4-position with 10% at the 6-position.	Chondroitin Sulfates	0-19	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	141-148
11791576-1	2001	Chondroitin sulfate (CS) is a glycosaminoglycan consisting of repeating uronic acid, N-acetylgalactosamine sulfate disaccharide units [-UroA(beta1,3)-GalNAcS(beta1,4)]n. Chondroitin sulfate type A (CSA) contains glucuronic acid, and 90% of the GalNAc residues are sulfated at the 4-position with 10% at the 6-position.	Chondroitin Sulfates	0-19	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	158-165
11791576-1	2001	Chondroitin sulfate (CS) is a glycosaminoglycan consisting of repeating uronic acid, N-acetylgalactosamine sulfate disaccharide units [-UroA(beta1,3)-GalNAcS(beta1,4)]n. Chondroitin sulfate type A (CSA) contains glucuronic acid, and 90% of the GalNAc residues are sulfated at the 4-position with 10% at the 6-position.	Chondroitin Sulfates	0-19	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	170-196
11791576-1	2001	Chondroitin sulfate (CS) is a glycosaminoglycan consisting of repeating uronic acid, N-acetylgalactosamine sulfate disaccharide units [-UroA(beta1,3)-GalNAcS(beta1,4)]n. Chondroitin sulfate type A (CSA) contains glucuronic acid, and 90% of the GalNAc residues are sulfated at the 4-position with 10% at the 6-position.	Chondroitin Sulfates	0-19	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	198-201
11748689-7	2001	Furthermore, in the presence of LPS, THP-1 produce slightly lower amounts of CS, whereas this mitogen significantly suppresses the HS synthesis in both culture medium and cell membrane.	Chondroitin Sulfates	77-79	GLI family zinc finger 2	Homo sapiens	37-42
11791576-1	2001	Chondroitin sulfate (CS) is a glycosaminoglycan consisting of repeating uronic acid, N-acetylgalactosamine sulfate disaccharide units [-UroA(beta1,3)-GalNAcS(beta1,4)]n. Chondroitin sulfate type A (CSA) contains glucuronic acid, and 90% of the GalNAc residues are sulfated at the 4-position with 10% at the 6-position.	Chondroitin Sulfates	21-23	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	141-148
11791576-1	2001	Chondroitin sulfate (CS) is a glycosaminoglycan consisting of repeating uronic acid, N-acetylgalactosamine sulfate disaccharide units [-UroA(beta1,3)-GalNAcS(beta1,4)]n. Chondroitin sulfate type A (CSA) contains glucuronic acid, and 90% of the GalNAc residues are sulfated at the 4-position with 10% at the 6-position.	Chondroitin Sulfates	21-23	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	158-165
11791576-1	2001	Chondroitin sulfate (CS) is a glycosaminoglycan consisting of repeating uronic acid, N-acetylgalactosamine sulfate disaccharide units [-UroA(beta1,3)-GalNAcS(beta1,4)]n. Chondroitin sulfate type A (CSA) contains glucuronic acid, and 90% of the GalNAc residues are sulfated at the 4-position with 10% at the 6-position.	Chondroitin Sulfates	21-23	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	170-196
11791576-1	2001	Chondroitin sulfate (CS) is a glycosaminoglycan consisting of repeating uronic acid, N-acetylgalactosamine sulfate disaccharide units [-UroA(beta1,3)-GalNAcS(beta1,4)]n. Chondroitin sulfate type A (CSA) contains glucuronic acid, and 90% of the GalNAc residues are sulfated at the 4-position with 10% at the 6-position.	Chondroitin Sulfates	21-23	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	198-201
11572857-1	2001	N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST) transfers sulfate from 3"-phosphoadenosine 5"-phosphosulfate to position 6 of N-acetylgalactosamine 4-sulfate (GalNAc(4SO(4))) in chondroitin sulfate and dermatan sulfate.	Chondroitin Sulfates	198-217	carbohydrate sulfotransferase 15	Homo sapiens	54-66
11731271-0	2001	Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH.	Chondroitin Sulfates	81-100	cathepsin D	Bos taurus	0-11
11731271-3	2001	It was also demonstrated that cathepsin D cleaved bovine aggrecan at five sites within the core protein, between residues Phe(342)-Phe(343) in the interglobular domain, Leu(1462)-Val(1463) between the chondroitin sulfate attachment regions 1 and 2 and Leu(1654)-Val(1655), Phe(1754)-Val(1755) and Leu(1854)-Ile(1855) that are located within the chondroitin sulfate attachment region 2 of the core protein.	Chondroitin Sulfates	201-220	cathepsin D	Bos taurus	30-41
11731271-3	2001	It was also demonstrated that cathepsin D cleaved bovine aggrecan at five sites within the core protein, between residues Phe(342)-Phe(343) in the interglobular domain, Leu(1462)-Val(1463) between the chondroitin sulfate attachment regions 1 and 2 and Leu(1654)-Val(1655), Phe(1754)-Val(1755) and Leu(1854)-Ile(1855) that are located within the chondroitin sulfate attachment region 2 of the core protein.	Chondroitin Sulfates	345-364	cathepsin D	Bos taurus	30-41
11606255-9	2001	In addition, the hepatic and renal activity of 5"-nucleotidase was inhibited by heparin and chondroitin sulfate, except for kidney membranes where chondroitin sulfate did not alter AMP hydrolysis.	Chondroitin Sulfates	92-111	5' nucleotidase, ecto	Rattus norvegicus	47-62
11606255-9	2001	In addition, the hepatic and renal activity of 5"-nucleotidase was inhibited by heparin and chondroitin sulfate, except for kidney membranes where chondroitin sulfate did not alter AMP hydrolysis.	Chondroitin Sulfates	147-166	5' nucleotidase, ecto	Rattus norvegicus	47-62
11572857-6	2001	The recombinant protein expressed from the human GalNAc4S-6ST cDNA transferred sulfate from 3"-phosphoadenosine 5"-phosphosulfate to position 6 of the nonreducing terminal and internal GalNAc(4SO(4)) residues contained in chondroitin sulfate A and dermatan sulfate.	Chondroitin Sulfates	222-243	carbohydrate sulfotransferase 15	Homo sapiens	49-61
11533493-4	2001	The jekyll mutation disrupts a homolog of Drosophila Sugarless, a uridine 5"-diphosphate (UDP)-glucose dehydrogenase required for heparan sulfate, chondroitin sulfate, and hyaluronic acid production.	Chondroitin Sulfates	147-166	sugarless	Drosophila melanogaster	53-62
11746383-0	2001	Fibronectin and laminin elicit differential behaviors from SH-SY5Y growth cones contacting inhibitory chondroitin sulfate proteoglycans.	Chondroitin Sulfates	102-121	fibronectin 1	Homo sapiens	0-11
11561889-1	2001	Biomimetic configurational arrays of hydroxyapatite (HAp) nanocrystals on several bio-organics, collagen (Col), chondroitin sulfate (ChS), and their mixture, were comparatively studied.	Chondroitin Sulfates	133-136	reticulon 3	Homo sapiens	53-56
11668612-2	2001	Mutations in the 4S gene are responsible for 4S deficiency, which leads to the intralysosomal storage of partially degraded glycosaminoglycans, dermatan sulfate, and chondroitin 4-sulfate.	Chondroitin Sulfates	166-187	arylsulfatase B	Homo sapiens	17-19
11668612-2	2001	Mutations in the 4S gene are responsible for 4S deficiency, which leads to the intralysosomal storage of partially degraded glycosaminoglycans, dermatan sulfate, and chondroitin 4-sulfate.	Chondroitin Sulfates	166-187	arylsulfatase B	Homo sapiens	45-47
11522680-5	2001	The glycosaminoglycans (GAGs) of the secreted PGs from insulin-treated HepG2 cells were enriched in chondroitin sulfate (CS) PGs.	Chondroitin Sulfates	100-119	insulin	Homo sapiens	55-62
11522680-5	2001	The glycosaminoglycans (GAGs) of the secreted PGs from insulin-treated HepG2 cells were enriched in chondroitin sulfate (CS) PGs.	Chondroitin Sulfates	121-123	insulin	Homo sapiens	55-62
11522680-7	2001	Insulin caused a moderate increase in mRNA for versican (secreted CS PG), whereas linoleic acid markedly decreased mRNA for versican in HepG2 cells, as did the peroxisomal proliferator-activated receptor-alpha agonist bezafibrate.	Chondroitin Sulfates	66-68	insulin	Homo sapiens	0-7
11522680-9	2001	The livers of obese Zucker fa/fa rats, which are insulin-resistant and have high levels of insulin, NEFAs, and triglyceride-rich remnants, showed increased expression of CS PGs when compared with lean littermates.	Chondroitin Sulfates	170-172	insulin	Homo sapiens	49-56
11518760-8	2001	In solid-phase assays, heparin, suramin, and chondroitin sulfates A and B efficiently inhibited the binding of apoE to heparan sulfate proteoglycans, but were unable to displace apoE from this glycosaminoglycan.	Chondroitin Sulfates	45-65	apolipoprotein E	Homo sapiens	111-115
11479316-4	2001	Here we analyzed the CS chain of appican, the CSPG form of the Alzheimer"s amyloid precursor protein.	Chondroitin Sulfates	21-23	amyloid beta (A4) precursor protein	Mus musculus	33-40
11479316-4	2001	Here we analyzed the CS chain of appican, the CSPG form of the Alzheimer"s amyloid precursor protein.	Chondroitin Sulfates	21-23	amyloid beta (A4) precursor protein	Mus musculus	75-100
11479316-6	2001	The present findings show that the CS chain of appican has a molecular mass of 25-50 kDa.	Chondroitin Sulfates	35-37	amyloid beta (A4) precursor protein	Mus musculus	47-54
11479316-9	2001	We also show that the CS chain of appican contains in its linkage region the 4-O-sulfated Gal structure.	Chondroitin Sulfates	22-24	amyloid beta (A4) precursor protein	Mus musculus	34-41
11526205-5	2001	In the rodent central nervous system, they are expressed exclusively in oligodendrocytes and oligodendrocyte progenitors, and Olig1 can promote formation of an chondroitin sulfate proteoglycon-positive glial progenitor.	Chondroitin Sulfates	160-179	oligodendrocyte transcription factor 1	Homo sapiens	126-131
11557064-0	2001	Modification of the laminin alpha 4 chain by chondroitin sulfate attachment to its N-terminal domain.	Chondroitin Sulfates	45-64	laminin subunit alpha 4	Homo sapiens	20-41
11557064-1	2001	The N-terminal domain of laminin alpha 4 chains corresponds to a short rod-like structure which after recombinant production was found to be modified by chondroitin sulfate.	Chondroitin Sulfates	153-172	laminin subunit alpha 4	Homo sapiens	25-40
11493670-0	2001	Chondroitin sulfate and cytoplasmic domain-dependent membrane targeting of the NG2 proteoglycan promotes retraction fiber formation and cell polarization.	Chondroitin Sulfates	0-19	chondroitin sulfate proteoglycan 4	Homo sapiens	79-82
11522298-4	2001	BLOX-1-CHO adhesion to FN-coated plates can also be suppressed by scavenger receptor ligands, such as OxLDL, polyinosinic acid (poly I), and dextran sulfate, but not by native LDL, acetylated LDL, polycytidylic acid (poly C), or chondroitin sulfate.	Chondroitin Sulfates	229-248	oxidized low density lipoprotein receptor 1	Bos taurus	0-6
11522298-4	2001	BLOX-1-CHO adhesion to FN-coated plates can also be suppressed by scavenger receptor ligands, such as OxLDL, polyinosinic acid (poly I), and dextran sulfate, but not by native LDL, acetylated LDL, polycytidylic acid (poly C), or chondroitin sulfate.	Chondroitin Sulfates	229-248	fibronectin 1	Bos taurus	23-25
11384972-0	2001	Structural characterization of heparan sulfate and chondroitin sulfate of syndecan-1 purified from normal murine mammary gland epithelial cells.	Chondroitin Sulfates	51-70	syndecan 1	Mus musculus	74-84
11384972-2	2001	Syndecan-1, present on the surfaces of normal murine mammary gland epithelial cells, is a transmembrane hybrid proteoglycan, which bears glycosaminoglycan (GAG) side chains of heparan sulfate (HS) and chondroitin sulfate (CS).	Chondroitin Sulfates	201-220	syndecan 1	Mus musculus	0-10
11384972-2	2001	Syndecan-1, present on the surfaces of normal murine mammary gland epithelial cells, is a transmembrane hybrid proteoglycan, which bears glycosaminoglycan (GAG) side chains of heparan sulfate (HS) and chondroitin sulfate (CS).	Chondroitin Sulfates	222-224	syndecan 1	Mus musculus	0-10
11340082-7	2001	Supporting these data, the cells examined expressed PTPzeta, a receptor-type protein-tyrosine phosphatase that exhibits high affinity to both midkine and pleiotrophin and harbors chondroitin sulfate chains.	Chondroitin Sulfates	179-198	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	52-59
11322893-0	2001	The chondroitin sulfate chain of bikunin-containing proteins in the inter-alpha-inhibitor family increases in size in inflammatory diseases.	Chondroitin Sulfates	4-23	alpha-1-microglobulin/bikunin precursor	Homo sapiens	33-40
11322893-3	2001	They are composed of homologous heavy chains (H1 and H2 for IalphaI; H3 for PalphaI) covalently linked by a protein-glycosaminoglycan-protein cross-link to bikunin, which is a chondroitin 4-sulfate proteoglycan.	Chondroitin Sulfates	176-197	alpha-1-microglobulin/bikunin precursor	Homo sapiens	156-163
11322893-5	2001	In this work, we provide evidence that, in inflammatory diseases, the chondroitin sulfate chain of bikunin increases in size proportionally to the severity of the inflammatory response.	Chondroitin Sulfates	70-89	alpha-1-microglobulin/bikunin precursor	Homo sapiens	99-106
11295432-9	2001	It is suggested that Ca(2+) generates the sulfate salt and interacts with other polar groups in the chondroitin sulfate chain, thereby causing bridging between UTI molecules.	Chondroitin Sulfates	100-119	alpha-1-microglobulin/bikunin precursor	Homo sapiens	160-163
11295432-10	2001	Several properties of UTI may be related to this interaction of Ca(2+) with chondroitin sulfate chains.	Chondroitin Sulfates	76-95	alpha-1-microglobulin/bikunin precursor	Homo sapiens	22-25
12940068-6	2001	Chondroitin sulfate A and chondroitin sulfate B reduced cell surface apoE by 23.6% and 15.3% respectively while incubations with chondrointin sulfate C not effective.	Chondroitin Sulfates	0-21	apolipoprotein E	Homo sapiens	69-73
11496947-2	2001	METHODS: IL-2 was encapsulated into gelatin and chondroitin-6-sulfate using an aqueous-based complex coacervation.	Chondroitin Sulfates	48-69	interleukin 2	Mus musculus	9-13
11925507-0	2001	Requirement of chondroitin sulfate/dermatan sulfate recognition in midkine-dependent migration of macrophages.	Chondroitin Sulfates	15-34	midkine	Homo sapiens	67-74
11925507-3	2001	MK-induced migration of peritoneal exudate macrophages was inhibited by heparin, chondroitin sulfate E and dermatan sulfate, but not by chondroitin sulfate D or chondroitin 6-sulfate.	Chondroitin Sulfates	81-100	midkine	Homo sapiens	0-2
11925507-6	2001	These results indicated that a chondroitin sulfate, i.e. an E-type oversulfated structure with dermatan sulfate domain, is involved in MK-induced migration of macrophages.	Chondroitin Sulfates	31-50	midkine	Homo sapiens	135-137
11311873-1	2001	Perineuronal nets (PNs) are known as chondroitin sulfate-rich, lattice-like coatings of the extracellular matrix ensheathing mainly GABAergic, parvalbumin-containing neurons especially in the cerebral cortex.	Chondroitin Sulfates	37-56	parvalbumin	Rattus norvegicus	143-154
11295432-0	2001	Calcium-induced changes in chondroitin sulfate chains of urinary trypsin inhibitor.	Chondroitin Sulfates	27-46	alpha-1-microglobulin/bikunin precursor	Homo sapiens	57-82
11295432-2	2001	It is suggested that UTI inhibits calcium influx in cultured cells and that the chondroitin sulfate chain of UTI may play an important role.	Chondroitin Sulfates	80-99	alpha-1-microglobulin/bikunin precursor	Homo sapiens	109-112
11295432-3	2001	In order to clarify the mechanistic features of this phenomenon, the chondroitin sulfate chain of UTI was analyzed by (1)H-NMR.	Chondroitin Sulfates	69-88	alpha-1-microglobulin/bikunin precursor	Homo sapiens	98-101
11295432-6	2001	The addition of Ca(2+) to UTI caused a chemical shift to downfield, line broadening and a reduction of T(1) values at several signals from chondroitin sulfate moiety (especially at axial H-2 of GalNAc), whereas Mg(2+) and Na(+) had no significant effect.	Chondroitin Sulfates	139-158	alpha-1-microglobulin/bikunin precursor	Homo sapiens	26-29
11493670-2	2001	Both the cytoplasmic domain and the chondroitin sulfate chain of NG2 appear to have roles in sorting NG2 to subcellular microdomains destined to become retraction fibers.	Chondroitin Sulfates	36-55	chondroitin sulfate proteoglycan 4	Homo sapiens	65-68
11493670-2	2001	Both the cytoplasmic domain and the chondroitin sulfate chain of NG2 appear to have roles in sorting NG2 to subcellular microdomains destined to become retraction fibers.	Chondroitin Sulfates	36-55	chondroitin sulfate proteoglycan 4	Homo sapiens	101-104
11222505-1	2001	Here we report that CD44 binds a chondroitin sulfate (CS) proteoglycan, aggrecan, a major component of cartilage.	Chondroitin Sulfates	33-52	CD44 molecule (Indian blood group)	Rattus norvegicus	20-24
11290371-1	2001	In the current study, two specific glycosaminoglycan lyases, chondroitinase AC and chondroitinase B, were utilized to examine the roles of chondroitin sulfates and dermatan sulfate in tumor metastasis and angiogenesis.	Chondroitin Sulfates	139-159	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	61-75
11290371-1	2001	In the current study, two specific glycosaminoglycan lyases, chondroitinase AC and chondroitinase B, were utilized to examine the roles of chondroitin sulfates and dermatan sulfate in tumor metastasis and angiogenesis.	Chondroitin Sulfates	139-159	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	83-97
11106655-3	2001	By using a novel quantitative approach for assessing proteoglycan glycosylation, we show here that removal of the globular domain from rat glypican-1 converts the proteoglycan from one that bears approximately 90% heparan sulfate (HS) to one that bears approximately 90% chondroitin sulfate.	Chondroitin Sulfates	271-290	glypican 1	Rattus norvegicus	139-149
11222505-1	2001	Here we report that CD44 binds a chondroitin sulfate (CS) proteoglycan, aggrecan, a major component of cartilage.	Chondroitin Sulfates	54-56	CD44 molecule (Indian blood group)	Rattus norvegicus	20-24
11222505-3	2001	In both cases, binding was blocked by a neutralizing anti-CD44 mAb or by the pretreatment of aggrecan with chondroitinase, but not hyaluronidase or keratanase, indicating that CD44 binds aggrecan in a manner dependent on CS side chains of aggrecan and that hyaluronic acid is not involved in the binding.	Chondroitin Sulfates	221-223	CD44 molecule (Indian blood group)	Rattus norvegicus	176-180
11342172-1	2001	We show that cell surface glycans, sialic acid and mannose-containing species, are involved beside glycosaminoglycans (GAGs), heparan sulfate and chondroitin sulfate in the binding of full length (1--68) RANTES not only to CCR5 positive human primary lymphocytes or macrophages but also to CCR5 negative monocytic U937 cells.	Chondroitin Sulfates	146-165	C-C motif chemokine receptor 5	Homo sapiens	223-227
11342172-1	2001	We show that cell surface glycans, sialic acid and mannose-containing species, are involved beside glycosaminoglycans (GAGs), heparan sulfate and chondroitin sulfate in the binding of full length (1--68) RANTES not only to CCR5 positive human primary lymphocytes or macrophages but also to CCR5 negative monocytic U937 cells.	Chondroitin Sulfates	146-165	C-C motif chemokine receptor 5	Homo sapiens	290-294
11077416-1	2000	The extracellular matrix glycoprotein tenascin-R (TN-R), colocalizing with hyaluronan, phosphacan, and aggregating chondroitin sulphate proteoglycans in the white and grey matter, is accumulated in perineuronal nets that surround different types of neurons in many brain regions.	Chondroitin Sulfates	115-135	tenascin R	Mus musculus	38-48
11746504-4	2001	Also, we observed that PGs synthesized in the presence of NaF (50 microM) exhibited a higher sensitivity to chondroitinase ABC than PGs synthesized by osteoblasts in the absence of NaF, suggesting an increase in the chondroitin sulfate moieties associated with the core protein of PGs.	Chondroitin Sulfates	216-235	C-X-C motif chemokine ligand 8	Homo sapiens	58-61
11148136-0	2001	Chondroitin sulfate is involved in lysosomal transport of lysozyme in U937 cells.	Chondroitin Sulfates	0-19	lysozyme	Homo sapiens	58-66
11377840-8	2001	In contrast, long-term depression in CA1 was impaired by digestion of chondroitin sulfates but appeared normal in tenascin-R mutants.	Chondroitin Sulfates	70-90	carbonic anhydrase 1	Mus musculus	37-40
11077416-1	2000	The extracellular matrix glycoprotein tenascin-R (TN-R), colocalizing with hyaluronan, phosphacan, and aggregating chondroitin sulphate proteoglycans in the white and grey matter, is accumulated in perineuronal nets that surround different types of neurons in many brain regions.	Chondroitin Sulfates	115-135	tenascin R	Mus musculus	50-54
10978312-9	2000	Direct interactions of MK with various glycosaminoglycans were then evaluated using surface plasmon resonance, showing that CS-E bound MK as strongly as heparin, followed by other over-sulfated CS isoforms, CS-H and CS-K.	Chondroitin Sulfates	124-126	midkine	Rattus norvegicus	23-25
10978312-9	2000	Direct interactions of MK with various glycosaminoglycans were then evaluated using surface plasmon resonance, showing that CS-E bound MK as strongly as heparin, followed by other over-sulfated CS isoforms, CS-H and CS-K.	Chondroitin Sulfates	124-126	midkine	Rattus norvegicus	135-137
10978312-0	2000	Neuronal cell adhesion, mediated by the heparin-binding neuroregulatory factor midkine, is specifically inhibited by chondroitin sulfate E. Structural ans functional implications of the over-sulfated chondroitin sulfate.	Chondroitin Sulfates	117-136	midkine	Rattus norvegicus	79-86
10978312-0	2000	Neuronal cell adhesion, mediated by the heparin-binding neuroregulatory factor midkine, is specifically inhibited by chondroitin sulfate E. Structural ans functional implications of the over-sulfated chondroitin sulfate.	Chondroitin Sulfates	200-219	midkine	Rattus norvegicus	79-86
10978312-11	2000	These findings indicate that CS chains containing the E unit as well as heparin-like glycosaminoglycans may be involved in the expression and/or modulation of the multiple neuroregulatory functions of MK such as neuronal adhesion and migration and promotion of neurite outgrowth.	Chondroitin Sulfates	29-31	midkine	Rattus norvegicus	201-203
10900194-2	2000	The present results show that glycosaminoglycans such as heparin, heparan sulfate, chondroitin sulfates A, B, and C, and sulfated compounds such as suramin and pentosan efficiently extract TIMP-3 from the postpartum rat uterus.	Chondroitin Sulfates	83-103	TIMP metallopeptidase inhibitor 3	Rattus norvegicus	189-195
10950950-0	2000	Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44.	Chondroitin Sulfates	19-38	versican	Homo sapiens	70-78
10950950-0	2000	Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44.	Chondroitin Sulfates	19-38	selectin L	Homo sapiens	83-93
10950950-0	2000	Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44.	Chondroitin Sulfates	19-38	selectin P	Homo sapiens	95-105
10950950-0	2000	Binding of a large chondroitin sulfate/dermatan sulfate proteoglycan, versican, to L-selectin, P-selectin, and CD44.	Chondroitin Sulfates	19-38	CD44 molecule (Indian blood group)	Homo sapiens	111-115
10950950-1	2000	Here we show that a large chondroitin sulfate proteoglycan, versican, derived from a renal adenocarcinoma cell line ACHN, binds L-selectin, P-selectin, and CD44.	Chondroitin Sulfates	26-45	versican	Homo sapiens	60-68
10950950-1	2000	Here we show that a large chondroitin sulfate proteoglycan, versican, derived from a renal adenocarcinoma cell line ACHN, binds L-selectin, P-selectin, and CD44.	Chondroitin Sulfates	26-45	selectin L	Homo sapiens	128-138
10950950-1	2000	Here we show that a large chondroitin sulfate proteoglycan, versican, derived from a renal adenocarcinoma cell line ACHN, binds L-selectin, P-selectin, and CD44.	Chondroitin Sulfates	26-45	selectin P	Homo sapiens	140-150
10950950-1	2000	Here we show that a large chondroitin sulfate proteoglycan, versican, derived from a renal adenocarcinoma cell line ACHN, binds L-selectin, P-selectin, and CD44.	Chondroitin Sulfates	26-45	CD44 molecule (Indian blood group)	Homo sapiens	156-160
10950950-2	2000	The binding was mediated by the interaction of the chondroitin sulfate (CS) chain of versican with the carbohydrate-binding domain of L- and P-selectin and CD44.	Chondroitin Sulfates	51-70	versican	Homo sapiens	85-93
10950950-2	2000	The binding was mediated by the interaction of the chondroitin sulfate (CS) chain of versican with the carbohydrate-binding domain of L- and P-selectin and CD44.	Chondroitin Sulfates	51-70	selectin P	Homo sapiens	141-151
10950950-2	2000	The binding was mediated by the interaction of the chondroitin sulfate (CS) chain of versican with the carbohydrate-binding domain of L- and P-selectin and CD44.	Chondroitin Sulfates	51-70	CD44 molecule (Indian blood group)	Homo sapiens	156-160
10950950-2	2000	The binding was mediated by the interaction of the chondroitin sulfate (CS) chain of versican with the carbohydrate-binding domain of L- and P-selectin and CD44.	Chondroitin Sulfates	72-74	versican	Homo sapiens	85-93
10950950-2	2000	The binding was mediated by the interaction of the chondroitin sulfate (CS) chain of versican with the carbohydrate-binding domain of L- and P-selectin and CD44.	Chondroitin Sulfates	72-74	selectin P	Homo sapiens	141-151
10950950-2	2000	The binding was mediated by the interaction of the chondroitin sulfate (CS) chain of versican with the carbohydrate-binding domain of L- and P-selectin and CD44.	Chondroitin Sulfates	72-74	CD44 molecule (Indian blood group)	Homo sapiens	156-160
10871629-1	2000	N-Acetylgalactosamine 4-sulfate 6-O-sulfotransferase (GalNAc4S-6ST), which transfers sulfate from 3"-phosphoadenosine 5"-phosphosulfate (PAPS) to position 6 of N-acetylgalactosamine 4-sulfate in chondroitin sulfate and dermatan sulfate, was purified 19,600-fold to apparent homogeneity from the squid cartilage.	Chondroitin Sulfates	195-214	carbohydrate sulfotransferase 15	Homo sapiens	54-66
11131125-1	2000	Testican is a putative extracellular heparan/ chondroitin sulfate proteoglycan of unknown function that is expressed in a variety of human tissues at widely different levels but is most abundant in the brain.	Chondroitin Sulfates	46-65	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1	Homo sapiens	0-8
10950950-4	2000	On the other hand, the binding to CD44 was inhibited by hyaluronic acid, chondroitin (CH), CS A, CS B, CS C, CS D, and CS E but not by HS or keratan sulfate.	Chondroitin Sulfates	103-107	CD44 molecule (Indian blood group)	Homo sapiens	34-38
10950950-6	2000	We also show that soluble L- and P-selectin directly bind to immobilized CS B, CS E, and HS and that soluble CD44 directly binds to immobilized hyaluronic acid, CH, and all the CS chains examined.	Chondroitin Sulfates	73-75	selectin P	Homo sapiens	33-43
10950950-7	2000	Consistent with these results, structural analysis showed that versican is modified with at least CS B and CS C. Thus, proteoglycans sufficiently modified with the appropriate glycosaminoglycans should be able to bind L-selectin, P-selectin, and/or CD44.	Chondroitin Sulfates	98-100	versican	Homo sapiens	63-71
10889192-1	2000	Interactions of the developmentally regulated chondroitin sulfate proteoglycan NG2 with human plasminogen and kringle domain-containing plasminogen fragments have been analyzed by solid-phase immunoassays and by surface plasmon resonance.	Chondroitin Sulfates	46-65	chondroitin sulfate proteoglycan 4	Homo sapiens	79-82
10998358-3	2000	Rat chondrosarcoma tumour contained full-length aggrecan and all of the individual peptides expected from single independent cleavages at each of the four aggrecanase sites in the chondroitin sulphate (CS) domain.	Chondroitin Sulfates	202-204	ADAM metallopeptidase with thrombospondin type 1 motif, 4	Rattus norvegicus	155-166
10998358-4	2000	Kinetic analysis of the products present in rat chondrosarcoma cell cultures treated with interleukin-1b showed that the first aggrecanase-mediated cleavages occurred at the four sites within the CS attachment region to generate two stable intermediates, Val(1)-Glu(1459) and Val(1)-Glu(1274).	Chondroitin Sulfates	196-198	interleukin 1 beta	Rattus norvegicus	90-104
10998358-4	2000	Kinetic analysis of the products present in rat chondrosarcoma cell cultures treated with interleukin-1b showed that the first aggrecanase-mediated cleavages occurred at the four sites within the CS attachment region to generate two stable intermediates, Val(1)-Glu(1459) and Val(1)-Glu(1274).	Chondroitin Sulfates	196-198	ADAM metallopeptidase with thrombospondin type 1 motif, 4	Rattus norvegicus	127-138
10998358-6	2000	It therefore appears that the aggrecanase-mediated processing of native aggrecan by chondrocytes in situ is initiated within the CS-attachment region and completed by cleavage within the interglobular domain.	Chondroitin Sulfates	129-131	ADAM metallopeptidase with thrombospondin type 1 motif, 4	Rattus norvegicus	30-41
11033981-2	2000	The present study assessed the effects of chondroitin sulfate on the activity of pancreatic lipase and lipid uptake into brush border membrane vesicles of the rat small intestine in vitro, and on the degree of fat storage induced in mice by the oral administration of a high-fat diet for 8 weeks.	Chondroitin Sulfates	42-61	pancreatic lipase	Rattus norvegicus	81-98
10961890-6	2000	Soluble heparin, heparan sulfate, chondroitin sulfate, and dermatan sulfate were shown to inhibit the hIL-10-induced expression of CD16 and CD64 in a concentration-dependent manner.	Chondroitin Sulfates	34-53	interleukin 10	Homo sapiens	102-108
10961890-6	2000	Soluble heparin, heparan sulfate, chondroitin sulfate, and dermatan sulfate were shown to inhibit the hIL-10-induced expression of CD16 and CD64 in a concentration-dependent manner.	Chondroitin Sulfates	34-53	Fc gamma receptor IIIa	Homo sapiens	131-135
10961890-6	2000	Soluble heparin, heparan sulfate, chondroitin sulfate, and dermatan sulfate were shown to inhibit the hIL-10-induced expression of CD16 and CD64 in a concentration-dependent manner.	Chondroitin Sulfates	34-53	Fc gamma receptor Ia	Homo sapiens	140-144
10905458-4	2000	The incorporation of chondroitin sulphate into gelatin gels, caused a marked increase in lysozyme loading capacity, and a slower release rate.	Chondroitin Sulfates	21-41	lysozyme	Homo sapiens	89-97
10965035-9	2000	Nex-1 binds to heparin, heparan sulfate, and chondroitin sulfate but not to chondroitin and chemically N- or O-desulfated heparin.	Chondroitin Sulfates	45-64	Annexin	Caenorhabditis elegans	0-5
11033981-6	2000	RESULTS: Chondroitin sulfate dose-dependently inhibited the pancreatic lipase activity in an assay system using triolein emulsified with phosphatidylcholine.	Chondroitin Sulfates	9-28	pancreatic lipase	Mus musculus	60-77
10937593-1	2000	PURPOSE: Neurocan, a nervous tissue-specific chondroitin sulfate proteoglycan synthesized primarily by neurons, is expressed abundantly in developing rat retina, whereas it is rarely expressed in adult rat retinas.	Chondroitin Sulfates	45-64	neurocan	Rattus norvegicus	9-17
10930576-3	2000	N-terminal sequencing analysis of the cleavage product revealed that ADAMTS-1 cleaves the Glu(1871)-Leu(1872) bond within the chondroitin sulfate attachment domain of aggrecan.	Chondroitin Sulfates	126-145	ADAM metallopeptidase with thrombospondin type 1 motif 1	Homo sapiens	69-77
10966840-11	2000	CONCLUSIONS: The studied combination of glucosamine HCl, sodium chondroitin sulfate and manganese ascorbate was found to be effective for the treatment of radiographically mild to moderate OA of the knee as measured by the ISK.	Chondroitin Sulfates	57-83	potassium voltage-gated channel subfamily E regulatory subunit 1	Homo sapiens	223-226
10967549-1	2000	A yeast two-hybrid screen was employed to identify ligands for the cytoplasmic domain of the NG2 chondroitin sulfate proteoglycan.	Chondroitin Sulfates	97-116	chondroitin sulfate proteoglycan 4	Homo sapiens	93-96
10751416-6	2000	In addition, OSM induced HA binding via a novel mechanism requiring sulfation of chondroitin sulfate chains linked to CD44.	Chondroitin Sulfates	81-100	CD44 molecule (Indian blood group)	Homo sapiens	118-122
10959709-12	2000	In conclusion, this fucosylated chondroitin sulfate from invertebrate origin reveals useful properties for an antithrombotic agent: inhibition of SMC proliferation, enhancement of endothelium wound repair and TFPI release.	Chondroitin Sulfates	32-51	tissue factor pathway inhibitor	Homo sapiens	209-213
10903882-8	2000	Conclusions These in vitro studies confirm the protective role of CS, which counteracts the IL-1beta induced effects and they confirm the importance of pressure on chondrocyte metabolism and morphology.	Chondroitin Sulfates	66-68	interleukin 1 beta	Homo sapiens	92-100
10866805-9	2000	These results suggest that midkine binds to a polysulfated domain in the chondroitin sulfate chain with a region of dermatan sulfate structure.	Chondroitin Sulfates	73-92	midkine	Mus musculus	27-34
10773191-2	2000	Here we provide evidence that TN-R derived from adult mouse brain expresses chondroitin sulfate (CS) glycosaminoglycans (GAGs), i.e. C-6S and C-4S, that are recognized by the CS/dermatan sulfate-specific monoclonal antibodies 473 HD and CS-56.	Chondroitin Sulfates	76-95	tenascin R	Mus musculus	30-34
10845626-1	2000	PURPOSE: To investigate expression of 6B4 proteoglycan/phosphacan, the major constituent of chondroitin sulfate proteoglycan and a possible modulator of neural network formation in the developing central nervous system, in developing rat retina.	Chondroitin Sulfates	92-111	protein tyrosine phosphatase, receptor type Z1	Rattus norvegicus	38-54
10857760-2	2000	Here, circular dichroism and fluorescence spectroscopic techniques are used to demonstrate that low molecular weight heparin and chondroitin sulfate cause significant changes in secondary and tertiary structure of IFN-gamma.	Chondroitin Sulfates	129-148	interferon gamma	Homo sapiens	214-223
10857760-3	2000	The results suggest that heparin and chondroitin sulfate modulate IFN-gamma activity by causing structural changes in the IFN-gamma dimer.	Chondroitin Sulfates	37-56	interferon gamma	Homo sapiens	66-75
10857760-3	2000	The results suggest that heparin and chondroitin sulfate modulate IFN-gamma activity by causing structural changes in the IFN-gamma dimer.	Chondroitin Sulfates	37-56	interferon gamma	Homo sapiens	122-131
10793130-0	2000	The microfibrillar proteins MAGP-1 and fibrillin-1 form a ternary complex with the chondroitin sulfate proteoglycan decorin.	Chondroitin Sulfates	83-102	microfibril associated protein 2	Bos taurus	28-34
10793130-0	2000	The microfibrillar proteins MAGP-1 and fibrillin-1 form a ternary complex with the chondroitin sulfate proteoglycan decorin.	Chondroitin Sulfates	83-102	fibrillin 1	Bos taurus	39-50
10793130-4	2000	A spatially analogous fibrillin-2 truncated protein did not coprecipitate the same sulfated molecule, suggesting that chondroitin sulfate proteoglycan binding in this region is specific for fibrillin-1.	Chondroitin Sulfates	118-137	fibrillin 1	Bos taurus	190-201
10955958-0	2000	Recombinant human thrombomodulin(csa+): a tool for analyzing Plasmodium falciparum adhesion to chondroitin-4-sulfate.	Chondroitin Sulfates	95-116	thrombomodulin	Homo sapiens	18-32
10955958-1	2000	The proteoglycan thrombomodulin has been shown to be involved, via its chondroitin-sulfate moiety, in the cytoadhesion of chondroitin-4-sulfate-binding-Plasmodium falciparum-infected erythrocytes to endothelial cells and syncytiotrophoblasts.	Chondroitin Sulfates	71-90	thrombomodulin	Homo sapiens	17-31
10955958-1	2000	The proteoglycan thrombomodulin has been shown to be involved, via its chondroitin-sulfate moiety, in the cytoadhesion of chondroitin-4-sulfate-binding-Plasmodium falciparum-infected erythrocytes to endothelial cells and syncytiotrophoblasts.	Chondroitin Sulfates	122-143	thrombomodulin	Homo sapiens	17-31
10955958-2	2000	We cloned and expressed in CHO and COS-7 cells a gene encoding soluble human recombinant thrombomodulin, with a chondroitin-4-sulfate moiety.	Chondroitin Sulfates	112-133	thrombomodulin	Homo sapiens	89-103
10955958-11	2000	Thrombomodulin immobilized on plastic or coupled to Dynabeads was used to purify specifically the infected erythrocytes that bind to chondroitin-4-sulfate.	Chondroitin Sulfates	133-154	thrombomodulin	Homo sapiens	0-14
10955958-14	2000	Finally, the direct binding of infected erythrocytes to immobilized thrombomodulin was used to screen for anti-chondroitin-4-sulfate-binding antibodies.	Chondroitin Sulfates	111-132	thrombomodulin	Homo sapiens	68-82
10773191-2	2000	Here we provide evidence that TN-R derived from adult mouse brain expresses chondroitin sulfate (CS) glycosaminoglycans (GAGs), i.e. C-6S and C-4S, that are recognized by the CS/dermatan sulfate-specific monoclonal antibodies 473 HD and CS-56.	Chondroitin Sulfates	97-99	tenascin R	Mus musculus	30-34
10773191-2	2000	Here we provide evidence that TN-R derived from adult mouse brain expresses chondroitin sulfate (CS) glycosaminoglycans (GAGs), i.e. C-6S and C-4S, that are recognized by the CS/dermatan sulfate-specific monoclonal antibodies 473 HD and CS-56.	Chondroitin Sulfates	175-177	tenascin R	Mus musculus	30-34
10773191-2	2000	Here we provide evidence that TN-R derived from adult mouse brain expresses chondroitin sulfate (CS) glycosaminoglycans (GAGs), i.e. C-6S and C-4S, that are recognized by the CS/dermatan sulfate-specific monoclonal antibodies 473 HD and CS-56.	Chondroitin Sulfates	175-177	tenascin R	Mus musculus	30-34
10773191-4	2000	Our findings suggest the functional implication of TN-R-linked CS GAGs in matrix interactions with fibronectin and TN-C that are likely to contribute to a modulation of cellular behavior and the macromolecular organization of matrix components in the developing or injured adult CNS.	Chondroitin Sulfates	63-65	tenascin R	Mus musculus	51-55
10722749-5	2000	In addition, endoglycan contains several potential glycosaminoglycan attachment sites and is modified with chondroitin sulfate.	Chondroitin Sulfates	107-126	podocalyxin like 2	Homo sapiens	13-23
10723065-4	2000	Here we provide first evidence that TN-R derived from whole rat brain or cultured oligodendrocytes expresses chondroitin sulfate (CS) glycosaminoglycans (GAGs), i.e., C-4S and C-6S, that are recognized by CS-56, a CS/dermatan sulfate-specific monoclonal antibody.	Chondroitin Sulfates	109-128	tenascin R	Rattus norvegicus	36-40
10723065-4	2000	Here we provide first evidence that TN-R derived from whole rat brain or cultured oligodendrocytes expresses chondroitin sulfate (CS) glycosaminoglycans (GAGs), i.e., C-4S and C-6S, that are recognized by CS-56, a CS/dermatan sulfate-specific monoclonal antibody.	Chondroitin Sulfates	130-132	tenascin R	Rattus norvegicus	36-40
10723065-4	2000	Here we provide first evidence that TN-R derived from whole rat brain or cultured oligodendrocytes expresses chondroitin sulfate (CS) glycosaminoglycans (GAGs), i.e., C-4S and C-6S, that are recognized by CS-56, a CS/dermatan sulfate-specific monoclonal antibody.	Chondroitin Sulfates	205-207	tenascin R	Rattus norvegicus	36-40
10723065-4	2000	Here we provide first evidence that TN-R derived from whole rat brain or cultured oligodendrocytes expresses chondroitin sulfate (CS) glycosaminoglycans (GAGs), i.e., C-4S and C-6S, that are recognized by CS-56, a CS/dermatan sulfate-specific monoclonal antibody.	Chondroitin Sulfates	205-207	tenascin R	Rattus norvegicus	36-40
10723065-6	2000	Furthermore, after transection of the postcommissural fornix in adult rat, CS-bearing TN-R was found to be stably upregulated at the lesion site.	Chondroitin Sulfates	75-77	tenascin R	Rattus norvegicus	86-90
10723065-7	2000	Our findings suggest the functional impact of TN-R-linked CS on neural cell adhesion and migration during brain morphogenesis and the contribution of TN-R to astroglial scar formation (CS-dependent) and axon growth inhibition (CS-independent), i.e., suppression of axon regeneration after CNS injury.	Chondroitin Sulfates	58-60	tenascin R	Rattus norvegicus	46-50
10723065-7	2000	Our findings suggest the functional impact of TN-R-linked CS on neural cell adhesion and migration during brain morphogenesis and the contribution of TN-R to astroglial scar formation (CS-dependent) and axon growth inhibition (CS-independent), i.e., suppression of axon regeneration after CNS injury.	Chondroitin Sulfates	185-187	tenascin R	Rattus norvegicus	150-154
10723065-7	2000	Our findings suggest the functional impact of TN-R-linked CS on neural cell adhesion and migration during brain morphogenesis and the contribution of TN-R to astroglial scar formation (CS-dependent) and axon growth inhibition (CS-independent), i.e., suppression of axon regeneration after CNS injury.	Chondroitin Sulfates	185-187	tenascin R	Rattus norvegicus	150-154
10748230-0	2000	The cysteine-rich domain of the macrophage mannose receptor is a multispecific lectin that recognizes chondroitin sulfates A and B and sulfated oligosaccharides of blood group Lewis(a) and Lewis(x) types in addition to the sulfated N-glycans of lutropin.	Chondroitin Sulfates	102-122	mannose receptor C-type 1	Homo sapiens	43-59
11124536-2	2000	PRG4 has characteristic motifs including somatomedin B and hemopexin domains, a chondroitin sulfate-attachment site and mucin-like repeats.	Chondroitin Sulfates	80-99	proteoglycan 4	Homo sapiens	0-4
10684260-7	2000	Glycosylation of alpha-dystroglycan is not necessary for this interaction, but binding is dependent upon the chondroitin sulfate side chains of biglycan.	Chondroitin Sulfates	109-128	biglycan	Mus musculus	144-152
11008173-1	2000	We have shown previously in the rat that biglycan, a recently discovered chondroitin sulfate proteoglycan, has neurotrophic effects which are mediated by its chondroitin/dermatan sulfate chains.	Chondroitin Sulfates	73-92	biglycan	Rattus norvegicus	41-49
10600521-5	1999	In vitro, different glycosaminoglycans, such as dermatan sulfate and chondroitin sulfate-C, also induce a dimer assembly of HARP.	Chondroitin Sulfates	69-90	pleiotrophin	Homo sapiens	124-128
10714610-8	2000	Furthermore, glycosaminoglycans with a sulfate residue, chondroitin sulfate B and C (each 10 microg/mL) also inhibited the binding of 125I-bFGF The in vivo transcytosis of 125I-bFGF from the luminal side to the brain was also inhibited by the presence of heparin (10 microg/mL) and poly-L-lysine (300 microM), whereas neither hyaruronic acid (10 microg/mL) nor insulin (10 microM) had any effect.	Chondroitin Sulfates	56-75	fibroblast growth factor 2	Bos taurus	139-143
10714610-8	2000	Furthermore, glycosaminoglycans with a sulfate residue, chondroitin sulfate B and C (each 10 microg/mL) also inhibited the binding of 125I-bFGF The in vivo transcytosis of 125I-bFGF from the luminal side to the brain was also inhibited by the presence of heparin (10 microg/mL) and poly-L-lysine (300 microM), whereas neither hyaruronic acid (10 microg/mL) nor insulin (10 microM) had any effect.	Chondroitin Sulfates	56-75	fibroblast growth factor 2	Bos taurus	177-181
10569780-2	1999	All women, independent of their gravida status, had anti-chondroitin sulfate A (CSA) adhesion antibodies which cross-reacted with heterologous strains, such as FCR3 and Palo-Alto(FUP)1, which were selected for CSA binding.	Chondroitin Sulfates	57-78	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	80-83
10536375-11	1999	Overall, these results show that the inhibitory action of DCN is dependent of substratum binding, is differentially mediated by its glycosaminoglycan side chains (chondroitin-sulfate vs. dermatan-sulfate chains), and is independent of a steric hindrance effect exerted by its glycosaminoglycan side chains.	Chondroitin Sulfates	163-182	decorin	Homo sapiens	58-61
10581158-5	1999	Among the polysaccharides, heparin, chondroitin sulphates A, B, and C, fucoidan, and dextran sulphate, CD69 dimer gives a weak binding signal with fucoidan.	Chondroitin Sulfates	36-57	CD69 molecule	Homo sapiens	103-107
10536375-7	1999	DCN bearing dermatan-sulfate chains (i.e., skin and cartilage DCN) was about 20-fold more effective in inhibiting cell migration than DCN bearing chondroitin-sulfate chains (i.e., bone DCN).	Chondroitin Sulfates	146-165	decorin	Homo sapiens	0-3
10536375-7	1999	DCN bearing dermatan-sulfate chains (i.e., skin and cartilage DCN) was about 20-fold more effective in inhibiting cell migration than DCN bearing chondroitin-sulfate chains (i.e., bone DCN).	Chondroitin Sulfates	146-165	decorin	Homo sapiens	62-65
10536375-7	1999	DCN bearing dermatan-sulfate chains (i.e., skin and cartilage DCN) was about 20-fold more effective in inhibiting cell migration than DCN bearing chondroitin-sulfate chains (i.e., bone DCN).	Chondroitin Sulfates	146-165	decorin	Homo sapiens	62-65
10933060-5	1999	Functional studies suggest that CD44RC enhances hyaluronan binding by adhering to chondroitin sulfate side-chains attached to cell surface CD44, generating a multivalent complex with increased avidity for hyaluronan.	Chondroitin Sulfates	82-101	CD44 molecule (Indian blood group)	Homo sapiens	32-36
10933060-5	1999	Functional studies suggest that CD44RC enhances hyaluronan binding by adhering to chondroitin sulfate side-chains attached to cell surface CD44, generating a multivalent complex with increased avidity for hyaluronan.	Chondroitin Sulfates	82-101	CD44 molecule (Indian blood group)	Homo sapiens	139-143
10482629-0	1999	Vaccinia virus envelope D8L protein binds to cell surface chondroitin sulfate and mediates the adsorption of intracellular mature virions to cells.	Chondroitin Sulfates	58-77	IMV membrane protein	Vaccinia virus	24-27
10482629-2	1999	In the present study we identified another viral envelope protein, D8L, that binds to chondroitin sulfate on cells.	Chondroitin Sulfates	86-105	IMV membrane protein	Vaccinia virus	67-70
10482629-11	1999	Virion binding assays revealed that A27L(+) D8L(-) and A27L(-) D8L(-) mutant virions bound less well to BSC40 cells, indicating that binding of viral D8L protein to cell surface chondroitin sulfate could be important for vaccinia virus entry.	Chondroitin Sulfates	178-197	IMV surface protein	Vaccinia virus	36-40
10482629-11	1999	Virion binding assays revealed that A27L(+) D8L(-) and A27L(-) D8L(-) mutant virions bound less well to BSC40 cells, indicating that binding of viral D8L protein to cell surface chondroitin sulfate could be important for vaccinia virus entry.	Chondroitin Sulfates	178-197	IMV surface protein	Vaccinia virus	55-59
10512851-4	1999	In 3-D collagen lattices in the presence or absence of HA and cross-linking chondroitin sulfate, MV3 cell migration and associated functions such as polarization and matrix reorganization were blocked by anti-beta1 and anti-alpha2 integrin mAbs, whereas mAbs blocking CD44, alpha3, alpha5, alpha6, or alphav integrins showed no effect.	Chondroitin Sulfates	76-95	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	209-214
10496918-2	1999	The placenta sequesters parasites that are able to cytoadhere to chondroitin sulfate A (CSA), a molecule expressed by the placental syncytiotrophoblast, while parasites from a nonpregnant host do not bind to CSA.	Chondroitin Sulfates	88-91	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	65-86
10601738-0	1999	Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan.	Chondroitin Sulfates	113-132	interphotoreceptor matrix proteoglycan 1	Homo sapiens	39-46
10601738-0	1999	Expression and characterization of the IPM 150 gene (IMPG1) product, a novel human photoreceptor cell-associated chondroitin-sulfate proteoglycan.	Chondroitin Sulfates	113-132	interphotoreceptor matrix proteoglycan 1	Homo sapiens	53-58
10512851-4	1999	In 3-D collagen lattices in the presence or absence of HA and cross-linking chondroitin sulfate, MV3 cell migration and associated functions such as polarization and matrix reorganization were blocked by anti-beta1 and anti-alpha2 integrin mAbs, whereas mAbs blocking CD44, alpha3, alpha5, alpha6, or alphav integrins showed no effect.	Chondroitin Sulfates	76-95	CD44 molecule (Indian blood group)	Homo sapiens	268-272
10512637-0	1999	Organization of the inter-alpha-inhibitor heavy chains on the chondroitin sulfate originating from Ser(10) of bikunin: posttranslational modification of IalphaI-derived bikunin.	Chondroitin Sulfates	62-81	alpha-1-microglobulin/bikunin precursor	Homo sapiens	110-117
10480944-3	1999	CHO cells overexpressing either of two APLP2 variants, differing in chondroitin sulfate (CS) attachment, exhibit a marked increase in chemotaxis toward type IV collagen and fibronectin but not to laminin, collagen types I and VII, and HSPGs.	Chondroitin Sulfates	68-87	amyloid-like protein 2	Cricetulus griseus	39-44
10480944-3	1999	CHO cells overexpressing either of two APLP2 variants, differing in chondroitin sulfate (CS) attachment, exhibit a marked increase in chemotaxis toward type IV collagen and fibronectin but not to laminin, collagen types I and VII, and HSPGs.	Chondroitin Sulfates	89-91	amyloid-like protein 2	Cricetulus griseus	39-44
10480944-4	1999	Cells overexpressing APLP2-751 (CS-modified) exhibited a greater migratory response to fibronectin and type IV collagen than their non-CS-attached counterparts (APLP2-763), suggesting that CS modification enhanced APLP2 effects on cell migration.	Chondroitin Sulfates	32-34	amyloid-like protein 2	Cricetulus griseus	21-26
10480944-4	1999	Cells overexpressing APLP2-751 (CS-modified) exhibited a greater migratory response to fibronectin and type IV collagen than their non-CS-attached counterparts (APLP2-763), suggesting that CS modification enhanced APLP2 effects on cell migration.	Chondroitin Sulfates	135-137	amyloid-like protein 2	Cricetulus griseus	21-26
10480944-4	1999	Cells overexpressing APLP2-751 (CS-modified) exhibited a greater migratory response to fibronectin and type IV collagen than their non-CS-attached counterparts (APLP2-763), suggesting that CS modification enhanced APLP2 effects on cell migration.	Chondroitin Sulfates	135-137	amyloid-like protein 2	Cricetulus griseus	21-26
10480944-5	1999	Moreover, in the presence of chondroitin sulfate, transfectants overexpressing APLP2-751 failed to exhibit this enhanced migration toward fibronectin.	Chondroitin Sulfates	29-48	amyloid-like protein 2	Cricetulus griseus	79-84
10480944-9	1999	Furthermore, APLP2 interactions with fibronectin and collagen IV appear to be potentiated by the addition of a CS chain to the core proteins.	Chondroitin Sulfates	111-113	amyloid-like protein 2	Cricetulus griseus	13-18
10512637-10	1999	Heavy chain 1 (HC1) and heavy chain 2 (HC2) are attached to the CS by a novel cross-link [Enghild, J. J., Salvesen, G., Hefta, S. A., Thogersen, I.	Chondroitin Sulfates	64-66	CYCS pseudogene 39	Homo sapiens	15-18
10512637-10	1999	Heavy chain 1 (HC1) and heavy chain 2 (HC2) are attached to the CS by a novel cross-link [Enghild, J. J., Salvesen, G., Hefta, S. A., Thogersen, I.	Chondroitin Sulfates	64-66	CYCS pseudogene 38	Homo sapiens	39-42
10512637-14	1999	The results indicate that HC1 is in close proximity to HC2 and both are near the less sulfated nonreducing end of the CS.	Chondroitin Sulfates	118-120	CYCS pseudogene 39	Homo sapiens	26-29
10456986-5	1999	In the present study, a novel monoclonal antibody (TC2) that recognizes a native epitope on glycosaminoglycans enriched in chondroitin-4-sulfate revealed a transient and restricted expression in the developing gerbil TM.	Chondroitin Sulfates	123-144	transcobalamin 2	Homo sapiens	51-54
10457372-1	1999	The expression of NG2 chondroitin sulfate has been widely associated with oligodendrocyte precursors in rodents.	Chondroitin Sulfates	22-41	chondroitin sulfate proteoglycan 4	Homo sapiens	18-21
10452537-1	1999	Large chondroitinsulphate-containing proteoglycan (versican) isolated from rabbit lung was cleaved by purified gelatinase A (MMP-2) and gelatinase B (MMP-9), as well as by crude enzyme extract from rabbit lung with hydraulic edema.	Chondroitin Sulfates	6-25	versican core protein	Oryctolagus cuniculus	51-59
10571405-1	1999	The expression and function of NG2, a transmembrane chondroitin sulfate proteoglycan was studied in human gliomas of various histological types in culture using immunocytochemistry and flow cytometry.	Chondroitin Sulfates	52-71	chondroitin sulfate proteoglycan 4	Homo sapiens	31-34
10452537-1	1999	Large chondroitinsulphate-containing proteoglycan (versican) isolated from rabbit lung was cleaved by purified gelatinase A (MMP-2) and gelatinase B (MMP-9), as well as by crude enzyme extract from rabbit lung with hydraulic edema.	Chondroitin Sulfates	6-25	matrix metalloproteinase-9	Oryctolagus cuniculus	136-148
10452537-1	1999	Large chondroitinsulphate-containing proteoglycan (versican) isolated from rabbit lung was cleaved by purified gelatinase A (MMP-2) and gelatinase B (MMP-9), as well as by crude enzyme extract from rabbit lung with hydraulic edema.	Chondroitin Sulfates	6-25	matrix metalloproteinase-9	Oryctolagus cuniculus	150-155
10452537-1	1999	Large chondroitinsulphate-containing proteoglycan (versican) isolated from rabbit lung was cleaved by purified gelatinase A (MMP-2) and gelatinase B (MMP-9), as well as by crude enzyme extract from rabbit lung with hydraulic edema.	Chondroitin Sulfates	6-25	72 kDa type IV collagenase	Oryctolagus cuniculus	111-123
10452537-1	1999	Large chondroitinsulphate-containing proteoglycan (versican) isolated from rabbit lung was cleaved by purified gelatinase A (MMP-2) and gelatinase B (MMP-9), as well as by crude enzyme extract from rabbit lung with hydraulic edema.	Chondroitin Sulfates	6-25	72 kDa type IV collagenase	Oryctolagus cuniculus	125-130
10424736-10	1999	By pretreatment of microscopic slides with chondroitinase AC or ABC immunostaining of fibronectin could be made possible in areas in which CS was abundantly present, suggesting that CS may mask fibronectin epitopes.	Chondroitin Sulfates	139-141	fibronectin 1	Canis lupus familiaris	86-97
10383394-0	1999	CD44, a cell surface chondroitin sulfate proteoglycan, mediates binding of interferon-gamma and some of its biological effects on human vascular smooth muscle cells.	Chondroitin Sulfates	21-40	CD44 molecule (Indian blood group)	Homo sapiens	0-4
10383394-0	1999	CD44, a cell surface chondroitin sulfate proteoglycan, mediates binding of interferon-gamma and some of its biological effects on human vascular smooth muscle cells.	Chondroitin Sulfates	21-40	interferon gamma	Homo sapiens	75-91
10383394-4	1999	We found that treatment of HASMC with chondroitinase ABC, an enzyme that degrades chondroitin sulfate GAG, reduced IFN-gamma binding by more than 50%.	Chondroitin Sulfates	82-101	interferon gamma	Homo sapiens	115-124
10383394-9	1999	The interaction of IFN-gamma with chondroitin sulfate GAG was confirmed by affinity chromatography of isolated cell-associated 35S-, 3H-labeled PG on a column with immobilized IFN-gamma.	Chondroitin Sulfates	34-53	interferon gamma	Homo sapiens	19-28
10383394-9	1999	The interaction of IFN-gamma with chondroitin sulfate GAG was confirmed by affinity chromatography of isolated cell-associated 35S-, 3H-labeled PG on a column with immobilized IFN-gamma.	Chondroitin Sulfates	34-53	interferon gamma	Homo sapiens	176-185
10383394-10	1999	The cell-associated PG that binds to IFN-gamma was a chondroitin sulfate PG (CSPG).	Chondroitin Sulfates	53-72	interferon gamma	Homo sapiens	37-46
10383394-12	1999	High molecular weight complexes between IFN-gamma and chondroitin 6-sulfate were observed in gel exclusion chromatography.	Chondroitin Sulfates	54-75	interferon gamma	Homo sapiens	40-49
10383394-13	1999	Additions of chondroitin 6-sulfate to cultured HASMC antagonized the antiproliferative effect and expression of major histocompatibility complex II antigens induced by IFN-gamma.	Chondroitin Sulfates	13-34	interferon gamma	Homo sapiens	168-177
10375392-5	1999	The lipid peroxidation and oxidative modification of apoE in VLDL mediated by Cu2+ and an aqueous radical generator were suppressed by GAG, heparan sulfate, heparin, and chondroitin sulfate A, even though GAGs demonstrated no ability to scavenge alpha,alpha-diphenyl-beta-picrylhydrazyl radical.	Chondroitin Sulfates	170-191	apolipoprotein E	Homo sapiens	53-57
10492020-4	1999	Chondroitin sulfate (CS) containing PGs are mainly organized as versican in the extracellular medium and as thrombomodulin and syndecan in the cell membrane.	Chondroitin Sulfates	0-19	thrombomodulin	Homo sapiens	108-122
10492020-4	1999	Chondroitin sulfate (CS) containing PGs are mainly organized as versican in the extracellular medium and as thrombomodulin and syndecan in the cell membrane.	Chondroitin Sulfates	21-23	thrombomodulin	Homo sapiens	108-122
10424736-10	1999	By pretreatment of microscopic slides with chondroitinase AC or ABC immunostaining of fibronectin could be made possible in areas in which CS was abundantly present, suggesting that CS may mask fibronectin epitopes.	Chondroitin Sulfates	182-184	fibronectin 1	Canis lupus familiaris	86-97
10222064-9	1999	Taken together, these data suggested that IL-4-mediated inhibition of TNFalpha-induced monocyte HA binding was dependent not only on protein synthesis, but also on N-linked glycosylation and chondroitin-sulfate modification of either CD44 or, alternatively, another monocyte protein(s) that may regulate the ability of CD44 to bind HA.	Chondroitin Sulfates	191-210	interleukin 4	Homo sapiens	42-46
10358101-1	1999	Bamacan is a chondroitin sulfate proteoglycan that abounds in basement membranes.	Chondroitin Sulfates	13-32	structural maintenance of chromosomes 3	Mus musculus	0-7
10318803-8	1999	These results altogether indicate that EXTL2/EXTR2 encodes the alpha1,4-N-acetylhexosaminyltransferase that transfers GalNAc/GlcNAc to the tetrasaccharide representing the common glycosaminoglycan-protein linkage region and that is most likely the critical enzyme that determines and initiates the heparin/heparan sulfate synthesis, separating it from the chondroitin sulfate/dermatan sulfate synthesis.	Chondroitin Sulfates	356-375	exostosin like glycosyltransferase 2	Homo sapiens	39-44
10318803-8	1999	These results altogether indicate that EXTL2/EXTR2 encodes the alpha1,4-N-acetylhexosaminyltransferase that transfers GalNAc/GlcNAc to the tetrasaccharide representing the common glycosaminoglycan-protein linkage region and that is most likely the critical enzyme that determines and initiates the heparin/heparan sulfate synthesis, separating it from the chondroitin sulfate/dermatan sulfate synthesis.	Chondroitin Sulfates	356-375	exostosin like glycosyltransferase 2	Homo sapiens	45-50
10323765-9	1999	Binding analysis in physiological solutions confirmed that chondroitin sulfate-rich proteoglycans from the smooth muscle cell matrix have a high affinity for Lp(a) and LDL.	Chondroitin Sulfates	59-78	lipoprotein(a)	Homo sapiens	158-163
10359644-5	1999	Western blotting of the CS proteoglycan showed that this had reactivity with antibodies raised against human versican.	Chondroitin Sulfates	24-26	versican	Homo sapiens	109-117
10359644-6	1999	Electron microscopy (EM) of the CS proteoglycan also revealed a versican-like structure, with one globular domain at each end of a long extended segment substituted with CS side chains, as well as a structure interpreted as being the heavy chain of ITI attached to CS chains.	Chondroitin Sulfates	32-34	versican	Homo sapiens	64-72
10344737-2	1999	Chondroitin sulfate (CS) glycosaminoglycan is a candidate biomarker as elevated levels of CS in peritumoral stroma of prostate cancer have been associated with prostate-specific antigen (PSA) failure.	Chondroitin Sulfates	0-19	kallikrein related peptidase 3	Homo sapiens	160-191
10344737-2	1999	Chondroitin sulfate (CS) glycosaminoglycan is a candidate biomarker as elevated levels of CS in peritumoral stroma of prostate cancer have been associated with prostate-specific antigen (PSA) failure.	Chondroitin Sulfates	21-23	kallikrein related peptidase 3	Homo sapiens	160-191
10344737-2	1999	Chondroitin sulfate (CS) glycosaminoglycan is a candidate biomarker as elevated levels of CS in peritumoral stroma of prostate cancer have been associated with prostate-specific antigen (PSA) failure.	Chondroitin Sulfates	90-92	kallikrein related peptidase 3	Homo sapiens	160-191
10344737-6	1999	In the subgroup of patients with preoperative serum PSA levels &lt; 10 ng/ml, CS was particularly useful in discriminating retrospectively those patients most suited for surgery (Kaplan-Meier plot; 14% PSA failures at 5 years for CS mean integrated absorbance cut point &lt; 7.0 versus 47% for CS &gt; or = 7.0, P = 0.0001).	Chondroitin Sulfates	78-80	kallikrein related peptidase 3	Homo sapiens	52-55
10344737-6	1999	In the subgroup of patients with preoperative serum PSA levels &lt; 10 ng/ml, CS was particularly useful in discriminating retrospectively those patients most suited for surgery (Kaplan-Meier plot; 14% PSA failures at 5 years for CS mean integrated absorbance cut point &lt; 7.0 versus 47% for CS &gt; or = 7.0, P = 0.0001).	Chondroitin Sulfates	78-80	kallikrein related peptidase 3	Homo sapiens	202-205
10222064-9	1999	Taken together, these data suggested that IL-4-mediated inhibition of TNFalpha-induced monocyte HA binding was dependent not only on protein synthesis, but also on N-linked glycosylation and chondroitin-sulfate modification of either CD44 or, alternatively, another monocyte protein(s) that may regulate the ability of CD44 to bind HA.	Chondroitin Sulfates	191-210	tumor necrosis factor	Homo sapiens	70-78
10222064-9	1999	Taken together, these data suggested that IL-4-mediated inhibition of TNFalpha-induced monocyte HA binding was dependent not only on protein synthesis, but also on N-linked glycosylation and chondroitin-sulfate modification of either CD44 or, alternatively, another monocyte protein(s) that may regulate the ability of CD44 to bind HA.	Chondroitin Sulfates	191-210	CD44 molecule (Indian blood group)	Homo sapiens	234-238
10228010-5	1999	CS-GrB complexes were very stable, remaining undissociated in salt concentrations upwards to 500 mM (pH 7.4).	Chondroitin Sulfates	0-2	granzyme B	Homo sapiens	3-6
10328871-3	1999	A variety of GAGs (heparin, heparan sulfate, chondroitin sulfate and hyaluronic acid), and a related sulfated polysaccharide (dextran sulfate), were found to interact with IFN-gamma as determined by inhibition of the binding of [125I]IFN-gamma to COLO-205 cells and binding to wells coated with GAGs.	Chondroitin Sulfates	45-64	interferon gamma	Homo sapiens	172-181
10228010-6	1999	On the basis of a capture enzyme immunoassay that accurately detects GrB, equivalent amounts of active free and CS-GrB, delivered by perforin or adenovirus, efficiently induced apoptosis in Jurkat cells and produced a similar time-dependent increase in caspase-3-like activity.	Chondroitin Sulfates	112-114	granzyme B	Homo sapiens	115-118
10228010-7	1999	CS-GrB processed isolated caspases-3 and -7 less efficiently than free granzyme.	Chondroitin Sulfates	0-2	granzyme B	Homo sapiens	3-6
10365758-4	1999	In order to establish that binding of parasite-infected red blood cells to TM is dependent on its containing chondroitin-4-sulfate (CSA), we have mutated the CSA-attachment site of murine TM, and expressed this mutant form (TMsergly) in COS-7 cells.	Chondroitin Sulfates	132-135	thrombomodulin	Mus musculus	75-77
10365758-4	1999	In order to establish that binding of parasite-infected red blood cells to TM is dependent on its containing chondroitin-4-sulfate (CSA), we have mutated the CSA-attachment site of murine TM, and expressed this mutant form (TMsergly) in COS-7 cells.	Chondroitin Sulfates	132-135	thrombomodulin	Mus musculus	188-190
10365758-4	1999	In order to establish that binding of parasite-infected red blood cells to TM is dependent on its containing chondroitin-4-sulfate (CSA), we have mutated the CSA-attachment site of murine TM, and expressed this mutant form (TMsergly) in COS-7 cells.	Chondroitin Sulfates	158-161	thrombomodulin	Mus musculus	75-77
10365758-4	1999	In order to establish that binding of parasite-infected red blood cells to TM is dependent on its containing chondroitin-4-sulfate (CSA), we have mutated the CSA-attachment site of murine TM, and expressed this mutant form (TMsergly) in COS-7 cells.	Chondroitin Sulfates	158-161	thrombomodulin	Mus musculus	188-190
10208870-1	1999	Prior analyses of recombinant CD44 fusion proteins have indicated that combinatorial splicing of variant exons exerts distal effects on chondroitin sulfate content and structure, which may regulate the biological properties of the respective CD44 isoforms.	Chondroitin Sulfates	136-155	CD44 molecule (Indian blood group)	Homo sapiens	30-34
10212210-2	1999	PF-4 binding has been shown to be independent of interleukin-8 receptors and could be inhibited by soluble chondroitin sulfate type glycosaminoglycans or by pretreatment of cells with chondroitinase ABC.	Chondroitin Sulfates	107-126	platelet factor 4	Bos taurus	0-4
10212210-3	1999	Here we present evidence that surface-expressed neutrophil glycosaminoglycans are of chondroitin sulfate type and that this species binds to the tetrameric form of PF-4.	Chondroitin Sulfates	85-104	platelet factor 4	Bos taurus	164-168
10212210-6	1999	Binding studies revealed that the interaction of chondroitin sulfate with PF-4 required at least 20 monosaccharide units for significant binding.	Chondroitin Sulfates	49-68	platelet factor 4	Bos taurus	74-78
10212210-7	1999	The di-O-sulfated disaccharide units in neutrophil glycosaminoglycans clearly promoted the affinity to PF-4, which showed a Kd approximately 0.8 microM, as the affinities of bovine cartilage chondroitin sulfate A, porcine skin dermatan sulfate, or bovine cartilage chondroitin sulfate C, all consisting exclusively of monosulfated disaccharide units, were found to be 3-5-fold lower.	Chondroitin Sulfates	191-212	platelet factor 4	Bos taurus	103-107
10212210-8	1999	Taken together, our data indicate that chondroitin sulfate chains function as physiologically relevant binding sites for PF-4 on neutrophils and that the affinity of these chains for PF-4 is controlled by their degree of sulfation.	Chondroitin Sulfates	39-58	platelet factor 4	Bos taurus	121-125
10212223-12	1999	These results suggested that Arg78 in midkine plays an essential role in high affinity binding to PTPzeta by interacting with the chondroitin sulfate portion of this receptor.	Chondroitin Sulfates	130-149	midkine	Homo sapiens	38-45
10212223-12	1999	These results suggested that Arg78 in midkine plays an essential role in high affinity binding to PTPzeta by interacting with the chondroitin sulfate portion of this receptor.	Chondroitin Sulfates	130-149	protein tyrosine phosphatase receptor type Z1	Homo sapiens	98-105
10208870-1	1999	Prior analyses of recombinant CD44 fusion proteins have indicated that combinatorial splicing of variant exons exerts distal effects on chondroitin sulfate content and structure, which may regulate the biological properties of the respective CD44 isoforms.	Chondroitin Sulfates	136-155	CD44 molecule (Indian blood group)	Homo sapiens	242-246
10094837-0	1999	Alternatively spliced CD44 isoforms containing exon v10 promote cellular adhesion through the recognition of chondroitin sulfate-modified CD44.	Chondroitin Sulfates	109-128	CD44 molecule (Indian blood group)	Homo sapiens	22-26
10187838-0	1999	Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate.	Chondroitin Sulfates	135-154	uronyl 2-sulfotransferase	Homo sapiens	50-75
10196174-11	1999	However, enzymatic removal of the chondroitin sulfate chains from biglycan proteoglycan does not induce a shift to the core protein structure, suggesting that the final form is influenced by polysaccharide addition only during biosynthesis.	Chondroitin Sulfates	34-53	biglycan	Homo sapiens	66-74
10094837-0	1999	Alternatively spliced CD44 isoforms containing exon v10 promote cellular adhesion through the recognition of chondroitin sulfate-modified CD44.	Chondroitin Sulfates	109-128	CD44 molecule (Indian blood group)	Homo sapiens	138-142
10094837-5	1999	Pretreatment of TIL1 cells expressing CD44H or CD44R1 with chondroitinase ABC inhibited adhesion to CD44R2, suggesting that the unique inserted region present within the CD44R2 molecule, encoded by exon v10, mediates cell adhesion by potentiating the recognition of chondroitin sulfate moieties presented in association with other CD44 molecules.	Chondroitin Sulfates	266-285	CD44 molecule (Indian blood group)	Homo sapiens	38-42
10088675-1	1999	The NG2 antibody, which recognises an integral membrane chondroitin sulphate, labels a significant population of cells in adult CNS white matter tracts of the rat optic nerve and anterior medullary velum (AMV).	Chondroitin Sulfates	56-76	chondroitin sulfate proteoglycan 4	Rattus norvegicus	4-7
10101298-4	1999	We have previously shown that L-selectin reactive chondroitin sulfate and heparan sulfate proteoglycans (HSPGs) are both expressed in the distal tubules of the kidney and that versican is one of the chondroitin sulfate-type ligands.	Chondroitin Sulfates	50-69	selectin L	Homo sapiens	30-40
10075664-5	1999	We report that heparan sulfate, dermatan sulfate, and to a lesser extent, chondroitin sulfate A, displaced HARP bound to the extracellular compartment.	Chondroitin Sulfates	74-95	pleiotrophin	Mus musculus	107-111
10066769-11	1999	At early time points, both TGF-beta1 and serum induced substantial increases in perlecan bearing chondroitin sulfate and/or heparan sulfate chains.	Chondroitin Sulfates	97-116	transforming growth factor beta 1	Homo sapiens	27-36
10066769-13	1999	The levels of perlecan bearing chondroitin sulfate chains were elevated with TGF-beta1 treatment and were decreased with serum.	Chondroitin Sulfates	31-50	transforming growth factor beta 1	Homo sapiens	77-86
10739577-2	1999	Using a reliable marker for oligodendroglial progenitor cells in vivo, the NG2 chondroitin sulphate proteoglycan, we have evaluated the response of endogenous NG2(+) cells in the adult rat brain stem and cerebellum to inflammatory demyelinating lesions in an experimentally induced animal model of multiple sclerosis (MS), antibody augmented experimental allergic encephalomyelitis (ADEAE).	Chondroitin Sulfates	79-99	chondroitin sulfate proteoglycan 4	Rattus norvegicus	75-78
10914239-1	1999	Danaparoid sodium is an antithrombin composed of 3 glycosaminoglycans: heparan sulfate, dermatan sulfate and chondroitin sulfate.	Chondroitin Sulfates	109-128	serpin family C member 1	Homo sapiens	24-36
9990141-2	1999	Treatment of immunoprecipitated HSPG with HNO2, heparitinase, and chondroitinase ABC revealed that ACC3 cells synthesized HSPG molecules composed of 470-kDa core protein and heparan sulfate but not of chondroitin sulfate.	Chondroitin Sulfates	201-220	CD44 molecule (Indian blood group)	Homo sapiens	122-126
10050759-2	1999	Expression of chondroitin sulfate and heparan sulfate proteoglycans reactive with L-selectin.	Chondroitin Sulfates	14-33	selectin L	Homo sapiens	82-92
10050759-4	1999	Here we report that L-selectin-reactive molecules in the kidney are chondroitin sulfate and heparan sulfate proteoglycans of 500-1000 kDa, unlike those in HEV bearing sialyl Lewis X-like carbohydrates.	Chondroitin Sulfates	68-87	selectin L	Homo sapiens	20-30
10050759-7	1999	Thus, L-selectin can recognize chondroitin sulfate and heparan sulfate glycosaminoglycans structurally distinct from sialyl Lewis X-like carbohydrates.	Chondroitin Sulfates	31-50	selectin L	Homo sapiens	6-16
10064057-0	1999	Novel chondroitin sulfate-modified ligands for L-selectin on lymph node high endothelial venules.	Chondroitin Sulfates	6-25	selectin L	Rattus norvegicus	47-57
10064057-8	1999	Chondroitin sulfate-modified ligands for L-selectin were expressed at the HEC surface and by HEV in lymph nodes, suggesting that they may participate in lymphocyte interactions with HEV in vivo.	Chondroitin Sulfates	0-19	selectin L	Rattus norvegicus	41-51
10221651-6	1999	Binding of L-selectin-IgG chimera (LEC-IgG) to the isolated ligand was specifically blocked with either (i) anti-L-selectin mAb, (ii) EDTA, (iii) fucoidan, (iv) chondroitin sulfate (CS) B or CS E, or (v) treatment with chondroitinases.	Chondroitin Sulfates	161-180	selectin L	Homo sapiens	11-21
10221651-6	1999	Binding of L-selectin-IgG chimera (LEC-IgG) to the isolated ligand was specifically blocked with either (i) anti-L-selectin mAb, (ii) EDTA, (iii) fucoidan, (iv) chondroitin sulfate (CS) B or CS E, or (v) treatment with chondroitinases.	Chondroitin Sulfates	182-184	selectin L	Homo sapiens	11-21
9888791-6	1999	3H1, a monoclonal antibody that recognizes an epitope within the lipid-binding C-terminal domain of apoE, decreased binding of apoE to chondroitin sulfate proteoglycans in solid-phase assays by 77% and to heparan sulfate proteoglycans by 46%, suggesting that this region is of increased importance for binding to chondroitin sulfate proteoglycans.	Chondroitin Sulfates	313-332	apolipoprotein E	Homo sapiens	100-104
9891023-1	1999	Demonstration of the interaction between rantes and chondroitin sulfate.	Chondroitin Sulfates	52-71	C-C motif chemokine ligand 5	Homo sapiens	41-47
9891023-2	1999	All CD44 isoforms are modified with chondroitin sulfate (CS), while only those containing variably spliced exon V3 are modified with both CS and heparan sulfate (HS).	Chondroitin Sulfates	57-59	CD44 molecule (Indian blood group)	Homo sapiens	4-8
9891023-3	1999	The CS is added to a serine-glycine (SG) site in CD44 exon E5, while HS and CS are added to the SGSG site in exon V3.	Chondroitin Sulfates	4-6	CD44 molecule (Indian blood group)	Homo sapiens	49-53
9891023-4	1999	Site-directed mutagenesis and other molecular biology techniques were used to determine the minimal motifs responsible for the addition of CS and HS to CD44 (see accompanying paper (Greenfield, B., Wang, W.-C., Marquardt, H., Piepkorn, M., Wolff, E. A., Aruffo, A., and Bennett, K. L. (1999) J. Biol.	Chondroitin Sulfates	139-141	CD44 molecule (Indian blood group)	Homo sapiens	152-156
9891023-7	1999	We have used this information to generate artificial proteoglycans containing the extracellular domain of the cell adhesion protein lymphocyte function-associated antigen-3 (LFA-3) (CD58) and CD44 motifs modified with CS or a combination of CS and HS.	Chondroitin Sulfates	218-220	CD58 molecule	Homo sapiens	182-186
9891023-7	1999	We have used this information to generate artificial proteoglycans containing the extracellular domain of the cell adhesion protein lymphocyte function-associated antigen-3 (LFA-3) (CD58) and CD44 motifs modified with CS or a combination of CS and HS.	Chondroitin Sulfates	218-220	CD44 molecule (Indian blood group)	Homo sapiens	192-196
9891023-12	1999	While basic-fibroblast growth factor was shown to bind HS alone, this model revealed that RANTES binds not only HS, as has been demonstrated in the past, but also CS.	Chondroitin Sulfates	163-165	C-C motif chemokine ligand 5	Homo sapiens	90-96
9888791-5	1999	Further enzymatic and displacement analysis suggested that cell surface apoE associates specifically with GAGs containing chondroitin-4-sulfates.	Chondroitin Sulfates	122-144	apolipoprotein E	Homo sapiens	72-76
9888791-6	1999	3H1, a monoclonal antibody that recognizes an epitope within the lipid-binding C-terminal domain of apoE, decreased binding of apoE to chondroitin sulfate proteoglycans in solid-phase assays by 77% and to heparan sulfate proteoglycans by 46%, suggesting that this region is of increased importance for binding to chondroitin sulfate proteoglycans.	Chondroitin Sulfates	135-154	apolipoprotein E	Homo sapiens	100-104
9888791-6	1999	3H1, a monoclonal antibody that recognizes an epitope within the lipid-binding C-terminal domain of apoE, decreased binding of apoE to chondroitin sulfate proteoglycans in solid-phase assays by 77% and to heparan sulfate proteoglycans by 46%, suggesting that this region is of increased importance for binding to chondroitin sulfate proteoglycans.	Chondroitin Sulfates	135-154	apolipoprotein E	Homo sapiens	127-131
9888791-6	1999	3H1, a monoclonal antibody that recognizes an epitope within the lipid-binding C-terminal domain of apoE, decreased binding of apoE to chondroitin sulfate proteoglycans in solid-phase assays by 77% and to heparan sulfate proteoglycans by 46%, suggesting that this region is of increased importance for binding to chondroitin sulfate proteoglycans.	Chondroitin Sulfates	313-332	apolipoprotein E	Homo sapiens	127-131
9888791-10	1999	In summary, lipidated apoE associates with the HepG2 plasma membrane through interactions with chondroitin-4-sulfate containing GAGs and, to a lesser extent, HSPG.	Chondroitin Sulfates	95-116	apolipoprotein E	Homo sapiens	22-26
10447213-8	1999	GAGs and related molecules with higher sulfate content, heparin, chondroitin sulfate B, low and high molecular weight dextran sulfates significantly suppressed ET-1 production by HUVEC.	Chondroitin Sulfates	65-84	endothelin 1	Homo sapiens	160-164
9867844-4	1999	The third polypeptide, bikunin, has a molecular mass of 25 kDa and contains a 7-kDa chondroitin sulfate chain that is covalently linked to the C-terminal amino acid residues of H1 and H2.	Chondroitin Sulfates	84-103	alpha-1-microglobulin/bikunin precursor	Homo sapiens	23-30
9867844-4	1999	The third polypeptide, bikunin, has a molecular mass of 25 kDa and contains a 7-kDa chondroitin sulfate chain that is covalently linked to the C-terminal amino acid residues of H1 and H2.	Chondroitin Sulfates	84-103	fibroblast growth factor receptor 1	Homo sapiens	177-186
9987917-4	1999	The decrease in GUSB activity resulted in storage of GAGs predominantly heparan sulfate and chondroitin sulfate.	Chondroitin Sulfates	92-111	glucuronidase beta	Canis lupus familiaris	16-20
9842912-5	1998	Addition of chondroitin sulfate C to CXCR3-expressing murine pre-B cells allowed the determination of high-affinity binding for Mig and IP10 with Kd of 0.9-1.2 nM and 0.2-0.3 nM, respectively, and 1.3 x 10(4) binding sites per cell.	Chondroitin Sulfates	12-33	chemokine (C-X-C motif) receptor 3	Mus musculus	37-42
9950058-0	1998	Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module.	Chondroitin Sulfates	97-116	chondroitin sulfate proteoglycan 5	Rattus norvegicus	53-66
9950058-0	1998	Cloning and chromosomal mapping of the human gene of neuroglycan C (NGC), a neural transmembrane chondroitin sulfate proteoglycan with an EGF module.	Chondroitin Sulfates	97-116	chondroitin sulfate proteoglycan 5	Homo sapiens	68-71
9950058-5	1998	The domain structure characteristic of rat NGC was completely conserved in human NGC, which consisted of an N-terminal signal sequence, a chondroitin sulfate-attachment domain, an acidic amino acid cluster, an EGF-like domain, a transmembrane domain and a cytoplasmic tail.	Chondroitin Sulfates	138-157	chondroitin sulfate proteoglycan 5	Rattus norvegicus	43-46
10426522-7	1999	In brains showing hallmarks of Alzheimer"s disease, the characteristic patterns of hyperphosphorylated tau protein, stained with the AT8 antibody, largely excluded the zones abundant in perineuronal nets and neuropil-associated chondroitin sulphate proteoglycans.	Chondroitin Sulfates	228-248	microtubule associated protein tau	Homo sapiens	103-106
9875320-7	1998	RANTES binding to MDM was chondroitin sulfate, but not heparan sulfate, dependent, and RANTES bound more efficiently to MDM-5d than to MDM-MCSF.	Chondroitin Sulfates	26-45	C-C motif chemokine ligand 5	Homo sapiens	0-6
9875320-8	1998	Chondroitin sulfate removal partially offset the RANTES antiviral effect for MDM-5d.	Chondroitin Sulfates	0-19	C-C motif chemokine ligand 5	Homo sapiens	49-55
9792674-4	1998	We substituted lysine or histidine residues at the C-terminal end of MCP-1 with alanine residues and tested these mutants for their ability to bind heparin, heparan sulfate, hyaluronic acid, and chondroitin sulfate-C.	Chondroitin Sulfates	195-214	C-C motif chemokine ligand 2	Homo sapiens	69-74
9842912-5	1998	Addition of chondroitin sulfate C to CXCR3-expressing murine pre-B cells allowed the determination of high-affinity binding for Mig and IP10 with Kd of 0.9-1.2 nM and 0.2-0.3 nM, respectively, and 1.3 x 10(4) binding sites per cell.	Chondroitin Sulfates	12-33	chemokine (C-X-C motif) ligand 9	Mus musculus	128-131
9809475-2	1998	Whether basic fibroblast growth factor (bFGF) can stimulate proliferation and synthesis of chondroitin sulfate of chondrocytes in gel culture while maintaining the phenotype was studied.	Chondroitin Sulfates	91-110	fibroblast growth factor 2	Homo sapiens	8-38
9842912-5	1998	Addition of chondroitin sulfate C to CXCR3-expressing murine pre-B cells allowed the determination of high-affinity binding for Mig and IP10 with Kd of 0.9-1.2 nM and 0.2-0.3 nM, respectively, and 1.3 x 10(4) binding sites per cell.	Chondroitin Sulfates	12-33	chemokine (C-X-C motif) ligand 10	Mus musculus	136-140
9809475-2	1998	Whether basic fibroblast growth factor (bFGF) can stimulate proliferation and synthesis of chondroitin sulfate of chondrocytes in gel culture while maintaining the phenotype was studied.	Chondroitin Sulfates	91-110	fibroblast growth factor 2	Homo sapiens	40-44
9809475-6	1998	All doses of bFGF used in this study suppressed synthesis of chondroitin 6-sulfate.	Chondroitin Sulfates	61-82	fibroblast growth factor 2	Homo sapiens	13-17
9925366-7	1998	Fibronectin as a promoter of migration and adhesion was abundant, its antagonist tenascin and chondroitin sulfate showed patchy localization.	Chondroitin Sulfates	94-113	fibronectin 1	Canis lupus familiaris	0-11
9780212-5	1998	Reduction of PF-4 binding and PF-4-induced exocytosis in the presence of various glycosaminoglycans or following treatment of cells with chondroitinase ABC (but not other glycosaminoglycan-degrading enzymes) altogether demonstrates that the PF-4 receptor is a proteoglycan of the chondroitin sulfate class.	Chondroitin Sulfates	280-299	platelet factor 4	Homo sapiens	13-17
9795216-3	1998	Cloning and primary structure of neurocan, a developmentally regulated, aggregating, chondroitin sulfate proteoglycan of the brain.	Chondroitin Sulfates	85-104	neurocan	Mus musculus	33-41
9795242-2	1998	Measurement of the [35S]sulphate showed that IL-1alpha inhibited the synthesis of both keratan sulphate and chondroitin sulphate (CS) chains to a similar extent.	Chondroitin Sulfates	108-128	interleukin 1 alpha	Homo sapiens	45-54
9795242-2	1998	Measurement of the [35S]sulphate showed that IL-1alpha inhibited the synthesis of both keratan sulphate and chondroitin sulphate (CS) chains to a similar extent.	Chondroitin Sulfates	130-132	interleukin 1 alpha	Homo sapiens	45-54
9795242-6	1998	IL-1alpha did, however, inhibit [35S]sulphate incorporation into xyloside-linked CS chains.	Chondroitin Sulfates	81-83	interleukin 1 alpha	Homo sapiens	0-9
9780212-5	1998	Reduction of PF-4 binding and PF-4-induced exocytosis in the presence of various glycosaminoglycans or following treatment of cells with chondroitinase ABC (but not other glycosaminoglycan-degrading enzymes) altogether demonstrates that the PF-4 receptor is a proteoglycan of the chondroitin sulfate class.	Chondroitin Sulfates	280-299	platelet factor 4	Homo sapiens	30-34
9780212-5	1998	Reduction of PF-4 binding and PF-4-induced exocytosis in the presence of various glycosaminoglycans or following treatment of cells with chondroitinase ABC (but not other glycosaminoglycan-degrading enzymes) altogether demonstrates that the PF-4 receptor is a proteoglycan of the chondroitin sulfate class.	Chondroitin Sulfates	280-299	platelet factor 4	Homo sapiens	30-34
9730869-4	1998	Our results showed that stretch induced glycosaminoglycan production with increased antithrombin activity due to an increase in the concentration of active chondroitin sulfate.	Chondroitin Sulfates	156-175	serpin family C member 1	Homo sapiens	84-96
9875494-0	1998	Isolation and identification of chondroitin sulfates from the mud snail.	Chondroitin Sulfates	32-52	snail family transcriptional repressor 1	Homo sapiens	66-71
9875494-1	1998	Chondroitin sulfates were isolated from the mud snail.	Chondroitin Sulfates	0-20	snail family transcriptional repressor 1	Homo sapiens	48-53
9784651-6	1998	An isoform of Ii, known as chondroitin sulfate-modified Ii (IiCS), that is surface-expressed enhances T cell activation while acting as a coreceptor for CD44.	Chondroitin Sulfates	27-46	CD44 molecule (Indian blood group)	Homo sapiens	153-157
9777958-5	1998	A Western blot analysis using anti-human inter-alpha-trypsin inhibitor confirmed the identity of the small chondroitin sulfate proteoglycan as bikunin, and a trypsin inhibitor counterstain assay confirmed its anti-trypsin activity.	Chondroitin Sulfates	107-126	alpha-1-microglobulin/bikunin precursor	Homo sapiens	143-150
9737970-1	1998	The enzyme UDP-glucose dehydrogenase (Udpgdh) (EC 1.1.1.22) converts UDP-glucose to UDP-glucuronate, a critical component of the glycosaminoglycans, hyaluronan, chondroitin sulfate, and heparan sulfate.	Chondroitin Sulfates	161-180	UDP-glucose 6-dehydrogenase	Homo sapiens	11-36
9737970-1	1998	The enzyme UDP-glucose dehydrogenase (Udpgdh) (EC 1.1.1.22) converts UDP-glucose to UDP-glucuronate, a critical component of the glycosaminoglycans, hyaluronan, chondroitin sulfate, and heparan sulfate.	Chondroitin Sulfates	161-180	UDP-glucose 6-dehydrogenase	Homo sapiens	38-44
9655611-1	1998	PTPzeta/RPTPbeta is a receptor-like protein tyrosine phosphatase expressed as a chondroitin sulfate proteoglycan.	Chondroitin Sulfates	80-99	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	0-7
9671962-2	1998	Previous studies have demonstrated that these unusual glial cells, which can be identified by virtue of their expression of the NG2 chondroitin sulfate proteoglycan, react to traumatic brain injury.	Chondroitin Sulfates	132-151	chondroitin sulfate proteoglycan 4	Homo sapiens	128-131
9675317-12	1998	Levine, Inhibition of neurite outgrowth by the NG2 chondroitin sulfate proteoglycan, J. Neurosci.	Chondroitin Sulfates	51-70	chondroitin sulfate proteoglycan 4	Mus musculus	47-50
9651203-0	1998	Neuronal matrix metalloproteinase-2 degrades and inactivates a neurite-inhibiting chondroitin sulfate proteoglycan.	Chondroitin Sulfates	82-101	matrix metallopeptidase 2	Homo sapiens	9-35
9639683-1	1998	Chondroitin 6-sulfotransferase (C6ST) is the key enzyme in the biosynthesis of chondroitin 6-sulfate, a glycosaminoglycan implicated in chondrogenesis, neoplasia, atherosclerosis, and other processes.	Chondroitin Sulfates	79-100	carbohydrate sulfotransferase 3	Homo sapiens	0-30
9639683-1	1998	Chondroitin 6-sulfotransferase (C6ST) is the key enzyme in the biosynthesis of chondroitin 6-sulfate, a glycosaminoglycan implicated in chondrogenesis, neoplasia, atherosclerosis, and other processes.	Chondroitin Sulfates	79-100	carbohydrate sulfotransferase 3	Homo sapiens	32-36
9661054-5	1998	This proteoglycan contained mostly chondroitin sulfate chains, whose hydrodynamic size was increased by the addition of transforming growth factor-beta-1.	Chondroitin Sulfates	35-54	transforming growth factor beta 1	Bos taurus	120-153
9661054-6	1998	Further, the pattern of the proteoglycans appearing in the media of subcultures 2-4 was influenced by the addition of transforming growth factor-beta-1, so that while these control subcultures elaborated both the large and small chondroitin sulfate proteoglycans, the equivalent stimulated subcultures elaborated only intermediate sized chondroitin sulfate proteoglycan(s).	Chondroitin Sulfates	229-248	transforming growth factor beta 1	Bos taurus	118-151
9661054-6	1998	Further, the pattern of the proteoglycans appearing in the media of subcultures 2-4 was influenced by the addition of transforming growth factor-beta-1, so that while these control subcultures elaborated both the large and small chondroitin sulfate proteoglycans, the equivalent stimulated subcultures elaborated only intermediate sized chondroitin sulfate proteoglycan(s).	Chondroitin Sulfates	337-356	transforming growth factor beta 1	Bos taurus	118-151
9727071-7	1998	Features that can be acquired by the expression of CD44v4-v10 are an increased hyaluronate (HA) and a de novo chondroitin sulphate A (CS-A) binding.	Chondroitin Sulfates	110-132	chorionic somatomammotropin hormone 1	Homo sapiens	134-138
10197164-1	1998	OBJECTIVE: NG2 is a transmembrane chondroitin sulfate (CS) rich proteoglycan originally identified in rats.	Chondroitin Sulfates	34-53	chondroitin sulfate proteoglycan 4	Rattus norvegicus	11-14
10197164-1	1998	OBJECTIVE: NG2 is a transmembrane chondroitin sulfate (CS) rich proteoglycan originally identified in rats.	Chondroitin Sulfates	55-57	chondroitin sulfate proteoglycan 4	Rattus norvegicus	11-14
9692954-4	1998	Correctly folded PEDF bound to immobilized heparin, chondroitin sulfate-A, -B, -C, and dextran sulfate columns and eluted from each with an increase in NaCl concentration.	Chondroitin Sulfates	52-71	serpin family F member 1	Homo sapiens	17-21
9660874-1	1998	Pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) is a specific ligand of protein tyrosine phosphatase zeta (PTPzeta)/receptor-like protein tyrosine phosphatase beta (RPTPbeta) expressed in the brain as a chondroitin sulfate proteoglycan.	Chondroitin Sulfates	220-239	pleiotrophin	Homo sapiens	0-55
9660874-1	1998	Pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) is a specific ligand of protein tyrosine phosphatase zeta (PTPzeta)/receptor-like protein tyrosine phosphatase beta (RPTPbeta) expressed in the brain as a chondroitin sulfate proteoglycan.	Chondroitin Sulfates	220-239	pleiotrophin	Homo sapiens	57-63
9660874-1	1998	Pleiotrophin/heparin-binding growth-associated molecule (HB-GAM) is a specific ligand of protein tyrosine phosphatase zeta (PTPzeta)/receptor-like protein tyrosine phosphatase beta (RPTPbeta) expressed in the brain as a chondroitin sulfate proteoglycan.	Chondroitin Sulfates	220-239	protein tyrosine phosphatase receptor type Z1	Homo sapiens	124-131
9639520-0	1998	Differential effects of chondroitin sulfates A and B on monocyte and B-cell activation: evidence for B-cell activation via a CD44-dependent pathway.	Chondroitin Sulfates	24-44	CD44 molecule (Indian blood group)	Homo sapiens	125-129
9616153-5	1998	With TM containing chondroitin sulfate, heparin did not influence PC activation by thrombin, but with TM lacking chondroitin sulfate, the characteristic high-affinity PC interaction at low Ca2+ (approximately 50 to 100 micromol/L) was largely eliminated by heparin.	Chondroitin Sulfates	113-132	protein C, inactivator of coagulation factors Va and VIIIa	Homo sapiens	167-169
9622083-8	1998	Furthermore, like some mouse mAbs, human scFvs react with rat neural cells expressing the chondroitin sulfate proteoglycan NG2, which shows 81% homology to the HMW-MAA.	Chondroitin Sulfates	90-109	chondroitin sulfate proteoglycan 4	Rattus norvegicus	123-126
9622083-8	1998	Furthermore, like some mouse mAbs, human scFvs react with rat neural cells expressing the chondroitin sulfate proteoglycan NG2, which shows 81% homology to the HMW-MAA.	Chondroitin Sulfates	90-109	chondroitin sulfate proteoglycan 4	Homo sapiens	160-167
9622083-12	1998	In contrast to mouse mAb, scFv 61 immunoprecipitates the &gt;450-kDa chondroitin sulfate proteoglycan component of the HMW-MAA, but not its 250-kDa subunit from melanoma cells.	Chondroitin Sulfates	69-88	immunglobulin heavy chain variable region	Homo sapiens	26-30
9622083-12	1998	In contrast to mouse mAb, scFv 61 immunoprecipitates the &gt;450-kDa chondroitin sulfate proteoglycan component of the HMW-MAA, but not its 250-kDa subunit from melanoma cells.	Chondroitin Sulfates	69-88	chondroitin sulfate proteoglycan 4	Homo sapiens	119-126
9600379-1	1998	DSD-1-PG is a chondroitin sulfate proteoglycan with neurite-outgrowth promoting properties expressed during development and upon lesion of neural tissues which has been defined with the specific monoclonal antibody 473HD.	Chondroitin Sulfates	14-33	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	0-8
9655611-1	1998	PTPzeta/RPTPbeta is a receptor-like protein tyrosine phosphatase expressed as a chondroitin sulfate proteoglycan.	Chondroitin Sulfates	80-99	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	8-16
9596414-5	1998	The elastin-dependent mitogenic response of astrocytoma cells is abolished by lactose and chondroitin sulfate, factors which cause shedding of this 67-kDa elastin receptor from the cell surface and by blocking anti-EBP antibody.	Chondroitin Sulfates	90-109	elastin	Homo sapiens	4-11
9596414-5	1998	The elastin-dependent mitogenic response of astrocytoma cells is abolished by lactose and chondroitin sulfate, factors which cause shedding of this 67-kDa elastin receptor from the cell surface and by blocking anti-EBP antibody.	Chondroitin Sulfates	90-109	EBP cholestenol delta-isomerase	Homo sapiens	215-218
9596414-5	1998	The elastin-dependent mitogenic response of astrocytoma cells is abolished by lactose and chondroitin sulfate, factors which cause shedding of this 67-kDa elastin receptor from the cell surface and by blocking anti-EBP antibody.	Chondroitin Sulfates	90-109	elastin	Homo sapiens	155-162
9743814-9	1998	CS and its fractions inhibit the directional chemotaxis induced by zymosan-activated serum, are able to decrease the phagocytosis and the release of lysozyme induced by zymosan and to protect the plasma membrane from oxygen reactive species.	Chondroitin Sulfates	0-2	lysozyme	Homo sapiens	149-157
9743814-13	1998	In synovial fluid of patients requiring joint aspiration, treated orally for 10 days with CS (800 mg/day) the hyaluronate concentration and the intrinsic viscosity significantly increased, while collagenolytic activity, phospholipase A2 and N-acetylglucosaminidase (NAG) decreased.	Chondroitin Sulfates	90-92	phospholipase A2 group IB	Homo sapiens	220-236
9743814-13	1998	In synovial fluid of patients requiring joint aspiration, treated orally for 10 days with CS (800 mg/day) the hyaluronate concentration and the intrinsic viscosity significantly increased, while collagenolytic activity, phospholipase A2 and N-acetylglucosaminidase (NAG) decreased.	Chondroitin Sulfates	90-92	N-acetyl-alpha-glucosaminidase	Homo sapiens	241-264
9743814-13	1998	In synovial fluid of patients requiring joint aspiration, treated orally for 10 days with CS (800 mg/day) the hyaluronate concentration and the intrinsic viscosity significantly increased, while collagenolytic activity, phospholipase A2 and N-acetylglucosaminidase (NAG) decreased.	Chondroitin Sulfates	90-92	N-acetyl-alpha-glucosaminidase	Homo sapiens	266-269
9488672-7	1998	The affinity of HPRG for various GAGs measured in a competition assay decreased in the following order: heparin &gt; dermatan sulfate &gt; heparan sulfate &gt; chondroitin sulfate A.	Chondroitin Sulfates	160-181	histidine rich glycoprotein	Homo sapiens	16-20
9568695-7	1998	Other sulfated GAGs and related macromolecules were also effective in the enhancement of amylin fibril formation in the order of heparin &gt; heparan sulfate &gt; chondroitin-4-sulfate = dermatan sulfate = dextran sulfate &gt; pentosan polysulfate, implicating the importance of the specific GAG/carbohydrate backbone.	Chondroitin Sulfates	163-184	islet amyloid polypeptide	Homo sapiens	89-95
9490645-8	1998	This indicates that sulfation and, in particular, the addition of chondroitin sulfate are required for inducible hyaluronan binding by CD44 in L cells.	Chondroitin Sulfates	66-85	CD44 antigen	Mus musculus	135-139
9490645-10	1998	Thus, in addition to glycosylation, chondroitin sulfate biosynthesis is an important post-translational modification that can affect the hyaluronan binding ability of CD44.	Chondroitin Sulfates	36-55	CD44 antigen	Mus musculus	167-171
9507007-6	1998	The chondroitin sulfate chains on neurocan and phosphacan account for at least 80% of their binding to amphoterin and HB-GAM.	Chondroitin Sulfates	4-23	protein tyrosine phosphatase receptor type Z1	Homo sapiens	47-57
9507007-6	1998	The chondroitin sulfate chains on neurocan and phosphacan account for at least 80% of their binding to amphoterin and HB-GAM.	Chondroitin Sulfates	4-23	high mobility group box 1	Homo sapiens	103-113
9507007-6	1998	The chondroitin sulfate chains on neurocan and phosphacan account for at least 80% of their binding to amphoterin and HB-GAM.	Chondroitin Sulfates	4-23	pleiotrophin	Homo sapiens	118-124
9452446-1	1998	A mouse brain chondroitin sulfate (CS) proteoglycan, DSD-1-PG, bears the DSD-1 epitope and has neurite outgrowth promoting properties.	Chondroitin Sulfates	14-33	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	53-61
9538229-9	1998	L cells transfected with PTPzeta-A and -B cDNAs expressed these proteins as enzymatically active chondroitin sulfate proteoglycans.	Chondroitin Sulfates	97-116	protein tyrosine phosphatase, receptor type Z1	Rattus norvegicus	25-41
9452446-1	1998	A mouse brain chondroitin sulfate (CS) proteoglycan, DSD-1-PG, bears the DSD-1 epitope and has neurite outgrowth promoting properties.	Chondroitin Sulfates	35-37	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	53-61
9452446-2	1998	Shark cartilage CS-C inhibits the interactions between the DSD-1-specific monoclonal antibody 473HD and the CS chains of the DSD-1-PG, which is expressed on the mouse glial cells (Faissner, A., Clement, A., Lochter, A., Streit, A., Mandl, C., and Schachner, M. (1994) J.	Chondroitin Sulfates	16-18	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	125-133
9477985-6	1998	The absence of the 12-amino acid insert indicated that APLP2 could be modified by the addition of a chondroitin sulfate (CS) glycosaminoglycan chain.	Chondroitin Sulfates	100-119	amyloid beta precursor like protein 2	Rattus norvegicus	55-60
9631577-6	1998	Proteoglycan type M-CSF, which contains chondroitin sulfate chains, was found in 1992.	Chondroitin Sulfates	40-59	colony stimulating factor 1	Homo sapiens	18-23
9477985-6	1998	The absence of the 12-amino acid insert indicated that APLP2 could be modified by the addition of a chondroitin sulfate (CS) glycosaminoglycan chain.	Chondroitin Sulfates	121-123	amyloid beta precursor like protein 2	Rattus norvegicus	55-60
9477985-11	1998	The spatial and temporal expression of Kunitz protease inhibitor-containing, CS-modified APLP2 in healing corneal epithelium is consistent with its hypothesized role(s) in mediating reorganization of the extracellular matrix and dynamic cell-matrix adhesion during reepithelialization.	Chondroitin Sulfates	77-79	amyloid beta precursor like protein 2	Rattus norvegicus	89-94
9486530-0	1997	Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch).	Chondroitin Sulfates	23-43	versican	Mus musculus	57-65
9395468-6	1997	The developmental expression of the C6ST gene was also found to parallel the developmental down-regulation of both the C6ST activity and the chondroitin 6-sulfate structure.	Chondroitin Sulfates	141-162	carbohydrate sulfotransferase 3	Gallus gallus	36-40
9395524-2	1997	This stimulatory effect requires presence of the gamma-carboxyglutamic acid (Gla) domain in protein C and is enhanced by the presence of a chondroitin sulfate glycosaminoglycan (GAG) domain on thrombomodulin.	Chondroitin Sulfates	139-158	thrombomodulin	Homo sapiens	193-207
9395530-6	1997	A single point mutation in the most N-terminal hyaluronate binding motif of CD44 ablates both hyaluronate and chondroitin sulfate binding, suggesting that glycosaminoglycans are bound through a common motif, and that only one of the hyaluronate binding motifs is responsible for the majority of glycosaminoglycan binding by CD44 on the cell surface.	Chondroitin Sulfates	110-129	CD44 molecule (Indian blood group)	Homo sapiens	76-80
9390173-2	1997	This study describes the dependence of salt concentration on the binding properties of lysozyme isoforms of different cationic charges, isolated from bovine cartilage, to the two major and structurally similar glycosaminoglycans of cartilage, i.e., chondroitin sulfate and hyaluronan.	Chondroitin Sulfates	249-268	lysozyme C, tracheal isozyme	Bos taurus	87-95
9390173-3	1997	The binding of most cartilage lysozyme isoforms and hen egg-white lysozyme (control) to chondroitin sulfate and hyaluronan linked to agarose supports displayed optimal levels at approximately 20 and 5-10 mM salt, respectively, but decreased at both lower and higher salt concentrations indicating the electrostatic nature of the interactions.	Chondroitin Sulfates	88-107	lysozyme C, tracheal isozyme	Bos taurus	30-38
9390173-3	1997	The binding of most cartilage lysozyme isoforms and hen egg-white lysozyme (control) to chondroitin sulfate and hyaluronan linked to agarose supports displayed optimal levels at approximately 20 and 5-10 mM salt, respectively, but decreased at both lower and higher salt concentrations indicating the electrostatic nature of the interactions.	Chondroitin Sulfates	88-107	lysozyme C, tracheal isozyme	Bos taurus	66-74
9390173-4	1997	However, optimal binding of the most cationic lysozyme isoform to chondroitin sulfate occurred at 60 mM salt, with significant binding remaining at 150 mM.	Chondroitin Sulfates	66-85	lysozyme C, tracheal isozyme	Bos taurus	46-54
9486530-0	1997	Over-expression of the chondroitin sulphate proteoglycan versican is associated with defective neural crest migration in the Pax3 mutant mouse (splotch).	Chondroitin Sulfates	23-43	paired box 3	Mus musculus	125-129
9299551-0	1997	The role of chondroitin sulfate chains of urinary trypsin inhibitor in inhibition of LPS-induced increase of cytosolic free Ca2+ in HL60 cells and HUVEC cells.	Chondroitin Sulfates	12-31	carbonic anhydrase 2	Homo sapiens	124-127
9409362-10	1997	A skeletal muscle-specific form of the proteoglycan decorin, with a chondroitin sulfate-like epitope, is a target antigen for the IgM M-protein in our patient with Waldenstrom"s macroglobulinemia and a myopathy.	Chondroitin Sulfates	68-87	myomesin 2	Homo sapiens	134-143
9379060-5	1997	However, the binding of RANTES to activated macrophages occurred only at higher concentrations (100-300 nM) and was mostly chondroitin sulfate, and not HS, dependent.	Chondroitin Sulfates	123-142	C-C motif chemokine ligand 5	Homo sapiens	24-30
9349562-0	1997	Transient expression of PG-M/versican, a large chondroitin sulfate proteoglycan in developing chicken retina.	Chondroitin Sulfates	47-66	versican	Gallus gallus	24-28
9349562-0	1997	Transient expression of PG-M/versican, a large chondroitin sulfate proteoglycan in developing chicken retina.	Chondroitin Sulfates	47-66	versican	Gallus gallus	29-37
9349562-8	1997	Taken together, it is likely that PG-M/versican is involved in neurite outgrowth from ganglion cells during retinal development, and antiadhesion activity of its chondroitin sulfate chains may be important for regulation.	Chondroitin Sulfates	162-181	versican	Gallus gallus	34-38
9334256-0	1997	Widespread expression of chondroitin sulfate-type serglycins with CD44 binding ability in hematopoietic cells.	Chondroitin Sulfates	25-44	CD44 molecule (Indian blood group)	Homo sapiens	66-70
9334256-2	1997	We previously demonstrated that chondroitin sulfate-modified serglycin is a novel ligand for CD44 involved in the adherence and activation of lymphoid cells.	Chondroitin Sulfates	32-51	serglycin	Homo sapiens	61-70
9334256-2	1997	We previously demonstrated that chondroitin sulfate-modified serglycin is a novel ligand for CD44 involved in the adherence and activation of lymphoid cells.	Chondroitin Sulfates	32-51	CD44 molecule (Indian blood group)	Homo sapiens	93-97
9315899-10	1997	Purified brevican inhibits neurite outgrowth from cerebellar granule neurons in vitro, an activity that requires chondroitin sulfate chains.	Chondroitin Sulfates	113-132	brevican	Rattus norvegicus	9-17
9461640-0	1997	Modification of catalase by chondroitin sulfate.	Chondroitin Sulfates	28-47	catalase	Homo sapiens	16-24
9461640-1	1997	Catalase was chemically modified by sodium chondroitin sulfate using the benzoquinone binding method.	Chondroitin Sulfates	36-62	catalase	Homo sapiens	0-8
9461640-3	1997	Treatment of catalase and superoxide dismutase with benzoquinone-activated chondroitin sulfate results in a bienzymic conjugate with electrophoretically heterogenous composition.	Chondroitin Sulfates	75-94	catalase	Homo sapiens	13-21
9407499-10	1997	These chondroitin sulfate chains in the outer CSPG layer may be less effective in providing rigidity to the fibril core, thus allowing for the curved conformations of beta 2-microglobulin amyloid fibrils.	Chondroitin Sulfates	6-25	beta-2 microglobulin	Mus musculus	167-187
9348216-10	1997	Binding of IGFBP-2 to chondroitin-6-sulfate decreased the binding affinity of IGFBP-2 for IGF-I approximately 3-fold.	Chondroitin Sulfates	22-43	insulin-like growth factor binding protein 2	Rattus norvegicus	11-18
9348216-10	1997	Binding of IGFBP-2 to chondroitin-6-sulfate decreased the binding affinity of IGFBP-2 for IGF-I approximately 3-fold.	Chondroitin Sulfates	22-43	insulin-like growth factor binding protein 2	Rattus norvegicus	78-85
9348216-10	1997	Binding of IGFBP-2 to chondroitin-6-sulfate decreased the binding affinity of IGFBP-2 for IGF-I approximately 3-fold.	Chondroitin Sulfates	22-43	insulin-like growth factor 1	Rattus norvegicus	90-95
9348216-11	1997	Finally, an IGFBP-2 antibody coimmunoprecipitated IGFBP-2 and an approximately 200 kDa proteoglycan containing chondroitin-sulfate side chains from the rat olfactory bulb, providing definitive evidence for IGFBP-2 binding to olfactory bulb proteoglycans.	Chondroitin Sulfates	111-130	insulin-like growth factor binding protein 2	Rattus norvegicus	12-19
9359422-0	1997	Chondroitin sulphate composition and structure in alternatively spliced CD44 fusion proteins.	Chondroitin Sulfates	0-20	CD44 molecule (Indian blood group)	Homo sapiens	72-76
9359422-1	1997	Previous studies have indicated that CD44 isoforms, spliced with variant exons, are heterogeneously glycanated with chondroitin sulphate and heparan sulphate chains.	Chondroitin Sulfates	116-136	CD44 molecule (Indian blood group)	Homo sapiens	37-41
9359422-8	1997	Undersulphation of the recombinant chondroitin sulphates was shown by parallel analyses with native human keratinocyte CD44 molecules and is most probably an artifact of transient expression in COS cells.	Chondroitin Sulfates	35-56	CD44 molecule (Indian blood group)	Homo sapiens	119-123
9395105-3	1997	Unsaturated disaccharide isomers of chondroitin sulfate, obtained following chondroitinase ACII digestion, were analyzed by high-performance liquid chromatography.	Chondroitin Sulfates	36-55	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	76-90
9299551-5	1997	The Ca2+ binding capacity of deglycosylated UTI and UTI treated with monoclonal antibody of chondroitin sulfate was markedly depressed.	Chondroitin Sulfates	92-111	carbonic anhydrase 2	Homo sapiens	4-7
9299551-5	1997	The Ca2+ binding capacity of deglycosylated UTI and UTI treated with monoclonal antibody of chondroitin sulfate was markedly depressed.	Chondroitin Sulfates	92-111	alpha-1-microglobulin/bikunin precursor	Homo sapiens	44-47
9299551-5	1997	The Ca2+ binding capacity of deglycosylated UTI and UTI treated with monoclonal antibody of chondroitin sulfate was markedly depressed.	Chondroitin Sulfates	92-111	alpha-1-microglobulin/bikunin precursor	Homo sapiens	52-55
9299551-7	1997	These results suggest that UTI is a physiological Ca2+ chelator on the cells and that the action is due to chondroitin sulfate chains of UTI.	Chondroitin Sulfates	107-126	alpha-1-microglobulin/bikunin precursor	Homo sapiens	27-30
9299551-7	1997	These results suggest that UTI is a physiological Ca2+ chelator on the cells and that the action is due to chondroitin sulfate chains of UTI.	Chondroitin Sulfates	107-126	alpha-1-microglobulin/bikunin precursor	Homo sapiens	137-140
9198185-4	1997	The Ser/Thr-rich domain is variably modified with a chondroitin sulfate chain that influences the affinity of thrombin binding and the calcium ion dependence of cofactor function.	Chondroitin Sulfates	52-71	coagulation factor II, thrombin	Homo sapiens	110-118
9272947-4	1997	The ska gene encodes UDP-glucose dehydrogenase which produces glucuronic acid, an essential component for the synthesis of heparan and chondroitin sulfate.	Chondroitin Sulfates	135-154	sugarless	Drosophila melanogaster	4-7
9272947-4	1997	The ska gene encodes UDP-glucose dehydrogenase which produces glucuronic acid, an essential component for the synthesis of heparan and chondroitin sulfate.	Chondroitin Sulfates	135-154	sugarless	Drosophila melanogaster	21-46
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Chondroitin Sulfates	222-241	prothrombin	Oryctolagus cuniculus	59-67
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Chondroitin Sulfates	222-241	prothrombin	Oryctolagus cuniculus	69-77
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Chondroitin Sulfates	222-241	prothrombin	Oryctolagus cuniculus	69-77
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Chondroitin Sulfates	243-245	prothrombin	Oryctolagus cuniculus	59-67
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Chondroitin Sulfates	243-245	prothrombin	Oryctolagus cuniculus	69-77
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Chondroitin Sulfates	243-245	prothrombin	Oryctolagus cuniculus	69-77
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Chondroitin Sulfates	399-401	prothrombin	Oryctolagus cuniculus	59-67
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Chondroitin Sulfates	399-401	prothrombin	Oryctolagus cuniculus	69-77
9220985-1	1997	Mutation of three Arg residues, 93, 97, and 101, to Ala in thrombin (thrombin R93,97,101A) has previously been shown to eliminate most heparin acceleration of thrombin inhibition by antithrombin and most of the ability of chondroitin sulfate (CS) on thrombomodulin (TM) to enhance affinity for TM and to eliminate the characteristic high-affinity interaction with protein C observed with TM lacking CS.	Chondroitin Sulfates	399-401	prothrombin	Oryctolagus cuniculus	69-77
9220985-4	1997	In contrast, Arg 97 was the major residue required for TM-dependent acceleration of reactivity with antithrombin and for CS-dependent enhancement of TM affinity.	Chondroitin Sulfates	121-123	thrombomodulin	Oryctolagus cuniculus	149-151
9266027-6	1997	These results suggest that the increased amount of dermatan/chondroitin sulphate in SSc fibroblasts reflects an enhanced expression of decorin core protein.	Chondroitin Sulfates	60-80	decorin	Homo sapiens	135-142
9291994-0	1997	Inhibition of human leukocyte elastase activity by chondroitin sulfates.	Chondroitin Sulfates	51-71	elastase, neutrophil expressed	Homo sapiens	20-38
9291994-1	1997	Chondroitin sulfates with different properties and devoid of appreciable anticoagulant activity were evaluated for their capacity to inhibit human leukocyte elastase activity in vitro by using a chromogenic substrate.	Chondroitin Sulfates	0-20	elastase, neutrophil expressed	Homo sapiens	147-165
9291994-3	1997	The chondroitin sulfates with a molecular mass greater than about 2000 inhibited human leukocyte elastase activity to the same extent, whilst the fractions with a molecular mass of 1960 and 1020 were much less effective.	Chondroitin Sulfates	4-24	elastase, neutrophil expressed	Homo sapiens	87-105
9291994-4	1997	The percentage inhibition of human leukocyte elastase activity increased based on the charge density of chondroitin sulfates.	Chondroitin Sulfates	104-124	elastase, neutrophil expressed	Homo sapiens	35-53
9247577-2	1997	In humans, alternative splicing of up to 9 variant exons (v2-v10) into CD44 mRNA, together with post-translational modification via glycosylation and chondroitin sulfate attachment has the potential of generating a large number of CD44 isoforms.	Chondroitin Sulfates	150-169	CD44 molecule (Indian blood group)	Homo sapiens	231-235
9230913-3	1997	A marked increase of chondroitin sulfate (CS) was consistently detected in B2M amyloid.	Chondroitin Sulfates	21-40	beta-2-microglobulin	Homo sapiens	75-78
9184147-1	1997	Temperature and salt dependence studies of thrombin interaction with thrombomodulin, with and without chondroitin sulfate, and two fragments containing the EGF-like domains 4-5 and 4-5-6 reveal the energetic signatures and the mechanism of recognition of this physiologically important cofactor.	Chondroitin Sulfates	102-121	coagulation factor II, thrombin	Homo sapiens	43-51
9184147-3	1997	Binding of thrombomodulin has an unusually large salt dependence (gamma(salt) = -4.8) contributed mostly by the polyelectrolyte-like nature of the chondroitin sulfate moiety that binds to the heparin binding site and increases the affinity of the cofactor by almost 10-fold.	Chondroitin Sulfates	147-166	thrombomodulin	Homo sapiens	11-25
9184147-7	1997	These results demonstrate that recognition of thrombomodulin by thrombin is steered electrostatically by the highly charged regions of the fibrinogen recognition site and the heparin binding site, to which the chondroitin sulfate moiety binds and enhances the affinity of the interaction.	Chondroitin Sulfates	210-229	thrombomodulin	Homo sapiens	46-60
9184147-7	1997	These results demonstrate that recognition of thrombomodulin by thrombin is steered electrostatically by the highly charged regions of the fibrinogen recognition site and the heparin binding site, to which the chondroitin sulfate moiety binds and enhances the affinity of the interaction.	Chondroitin Sulfates	210-229	coagulation factor II, thrombin	Homo sapiens	64-72
9230913-3	1997	A marked increase of chondroitin sulfate (CS) was consistently detected in B2M amyloid.	Chondroitin Sulfates	42-44	beta-2-microglobulin	Homo sapiens	75-78
9099729-4	1997	Consistent with previous models of glycosaminoglycan attachment, roughly 50% of the recombinant NG2 fragments containing the central domain have chondroitin sulfate chains attached to the protein core.	Chondroitin Sulfates	145-164	chondroitin sulfate proteoglycan 4	Homo sapiens	96-99
9153251-11	1997	The known inhibitors of the interaction of alpha-dystroglycan with laminin-1, including EDTA, sulfatide, fucoidan, dextran sulfate, heparin, and sialic acid, also perturbed the adhesion of RT4 cells to laminin-1, whereas the reagents which do not inhibit the interaction, including dextran, chondroitin sulfate, dermatan sulfate, and GlcNAc, did not.	Chondroitin Sulfates	291-310	dystroglycan 1	Homo sapiens	49-61
9149236-2	1997	In this paper, we demonstrate that thrombomodulin, a proteoglycan present on endothelial cells and placental syncytiotrophoblasts, supports binding of selected lines of P. falciparum-infected erythrocytes in both static and flow-based assays, and that adhesion is dependent on the presence of the chondroitin sulfate A chain of thrombomodulin.	Chondroitin Sulfates	297-316	thrombomodulin	Homo sapiens	35-49
9149236-4	1997	Soluble thrombomodulin (with, but not without, its chondroitin sulfate chain) inhibited binding at 40 micrograms/ml, but not at physiological concentrations.	Chondroitin Sulfates	51-70	thrombomodulin	Homo sapiens	8-22
9149236-5	1997	Parasitized erythrocytes bound to cells expressing thrombomodulin, including human umbilical vein endothelial cells and A549 cells, and binding was inhibited by free chondroitin sulfate A.	Chondroitin Sulfates	166-187	thrombomodulin	Homo sapiens	51-65
9149236-6	1997	Established binding to A549 cells or to immobilized thrombomodulin was substantially reversed by chondroitin sulfate A at 10 micrograms/ml.	Chondroitin Sulfates	97-118	thrombomodulin	Homo sapiens	52-66
9149236-7	1997	The chondroitin sulfate chain of thrombomodulin is a receptor for malaria-infected erythrocytes in static assays and under physiological flow.	Chondroitin Sulfates	4-23	thrombomodulin	Homo sapiens	33-47
9111016-4	1997	The highest acceptor activity was determined by the sequence Q-E-E-E-E-G-S-G-G-G-Q, which was found in the single chondroitin sulfate attachment site of bikunin, the inhibitory active component of the human inter-alpha-trypsin inhibitor.	Chondroitin Sulfates	114-133	alpha-1-microglobulin/bikunin precursor	Homo sapiens	153-160
9148753-1	1997	Decorin (DCN) is a ubiquitous proteoglycan comprised of a core protein attached to a single dermatan/chondroitin sulphate glycosaminoglycan chain.	Chondroitin Sulfates	101-121	decorin	Homo sapiens	0-7
9083279-2	1997	Decorin is a protein composed of a core protein and a chondroitin sulfate side chain and is capable of inactivating TGF-beta.	Chondroitin Sulfates	54-73	decorin	Rattus norvegicus	0-7
9083279-2	1997	Decorin is a protein composed of a core protein and a chondroitin sulfate side chain and is capable of inactivating TGF-beta.	Chondroitin Sulfates	54-73	transforming growth factor, beta 1	Rattus norvegicus	116-124
9148753-1	1997	Decorin (DCN) is a ubiquitous proteoglycan comprised of a core protein attached to a single dermatan/chondroitin sulphate glycosaminoglycan chain.	Chondroitin Sulfates	101-121	decorin	Homo sapiens	9-12
9013976-0	1997	Secreted chondroitin sulfate proteoglycan of human B cell lines binds to the complement protein C1q and inhibits complex formation of C1.	Chondroitin Sulfates	9-28	complement C1q A chain	Homo sapiens	96-99
9056268-1	1997	Platelet-derived growth factor (PDGF) stimulates not only the proliferation and migration of arterial smooth muscle cells (ASMCs), but also the transcription, translation, and posttranslational processing of versican, a large chondroitin sulfate proteoglycan present in the extracellular matrix of blood vessels.	Chondroitin Sulfates	226-245	versican	Homo sapiens	208-216
9013976-6	1997	Binding of C1q to CSPG was competitively inhibited by free glycosaminoglycans (GAG) in the order dextran sulfate &gt; heparin &gt; heparan sulfate &gt; chondroitin-6-sulfate (CS-C) &gt; dermatan sulfate (CS-B) &gt; chondroitin-4-sulfate (CS-A).	Chondroitin Sulfates	152-173	complement C1q A chain	Homo sapiens	11-14
9013976-6	1997	Binding of C1q to CSPG was competitively inhibited by free glycosaminoglycans (GAG) in the order dextran sulfate &gt; heparin &gt; heparan sulfate &gt; chondroitin-6-sulfate (CS-C) &gt; dermatan sulfate (CS-B) &gt; chondroitin-4-sulfate (CS-A).	Chondroitin Sulfates	215-236	complement C1q A chain	Homo sapiens	11-14
9013976-6	1997	Binding of C1q to CSPG was competitively inhibited by free glycosaminoglycans (GAG) in the order dextran sulfate &gt; heparin &gt; heparan sulfate &gt; chondroitin-6-sulfate (CS-C) &gt; dermatan sulfate (CS-B) &gt; chondroitin-4-sulfate (CS-A).	Chondroitin Sulfates	238-242	complement C1q A chain	Homo sapiens	11-14
8995662-9	1997	Chondroitin sulfate A, in contrast, inhibited gB2 binding to heparin only at high levels (ED50 = 65 microg/ml).	Chondroitin Sulfates	0-21	gamma-aminobutyric acid type B receptor subunit 2	Homo sapiens	46-49
9041375-6	1997	IL-1 significantly increased CS in normal and Apert media, whereas IL-6 enhanced HS and DS in media of both populations.	Chondroitin Sulfates	29-31	interleukin 1 alpha	Homo sapiens	0-4
8940162-7	1996	With chondroitin sulfate-containing soluble thrombomodulin produced from either human melanoma cells Bowes or Chinese hamster ovary cells, a higher percentage of molecules bound thrombin and, in some cases, two thrombin molecules were attached to one soluble thrombomodulin in approximately the same region.	Chondroitin Sulfates	5-24	thrombomodulin	Homo sapiens	44-58
8940162-7	1996	With chondroitin sulfate-containing soluble thrombomodulin produced from either human melanoma cells Bowes or Chinese hamster ovary cells, a higher percentage of molecules bound thrombin and, in some cases, two thrombin molecules were attached to one soluble thrombomodulin in approximately the same region.	Chondroitin Sulfates	5-24	coagulation factor II, thrombin	Homo sapiens	178-186
8940162-7	1996	With chondroitin sulfate-containing soluble thrombomodulin produced from either human melanoma cells Bowes or Chinese hamster ovary cells, a higher percentage of molecules bound thrombin and, in some cases, two thrombin molecules were attached to one soluble thrombomodulin in approximately the same region.	Chondroitin Sulfates	5-24	coagulation factor II, thrombin	Homo sapiens	211-219
8940162-7	1996	With chondroitin sulfate-containing soluble thrombomodulin produced from either human melanoma cells Bowes or Chinese hamster ovary cells, a higher percentage of molecules bound thrombin and, in some cases, two thrombin molecules were attached to one soluble thrombomodulin in approximately the same region.	Chondroitin Sulfates	5-24	thrombomodulin	Cricetulus griseus	259-273
9023544-2	1996	We report here a new and highly sensitive method for the detection and quantitation of all nonreducing terminal residues and internal disaccharides obtained by chondroitinase ABC or ACII digestion of aggrecan chondroitin sulfate.	Chondroitin Sulfates	209-228	galactosamine (N-acetyl)-6-sulfatase	Rattus norvegicus	160-174
8958300-15	1996	Tumor staining with anti-chondroitin sulfate monoclonal antibodies suggests that CD44s may be expressed as a chondroitin sulfate proteoglycan in primary melanomas.	Chondroitin Sulfates	25-44	CD44 antigen	Mus musculus	81-85
8958300-15	1996	Tumor staining with anti-chondroitin sulfate monoclonal antibodies suggests that CD44s may be expressed as a chondroitin sulfate proteoglycan in primary melanomas.	Chondroitin Sulfates	109-128	CD44 antigen	Mus musculus	81-85
9194600-1	1997	Capillary zone electrophoresis (CZE) was used to separate the disaccharides produced by chondroitinase digestion of chondroitin sulfates.	Chondroitin Sulfates	116-136	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	88-102
9117561-5	1996	Splicing out of exon 15 results in the joining of exons 14 and 16, and formation of an Asp-Xaa-Ser-Gly consensus sequence for chondroitin sulfate chain attachment to serine 619 of L-APP, which lies 16 amino acids upstream of the A beta peptide sequence.	Chondroitin Sulfates	126-145	amyloid beta precursor protein	Rattus norvegicus	229-235
8910306-7	1996	In addition, direct binding of N-CAM to chondroitin sulfate could be demonstrated.	Chondroitin Sulfates	40-59	neural cell adhesion molecule 1	Homo sapiens	31-36
8944711-3	1996	The percentage of cells incorporating BrdU was significantly elevated by desulfated chondroitin sulfate in the presence of fibroblast growth factor-2 (FGF-2 or basic FGF) and depressed by heparin in the presence of either FGF-1 or acidic FGF or FGF-2.	Chondroitin Sulfates	84-103	fibroblast growth factor 2	Rattus norvegicus	123-149
8944711-3	1996	The percentage of cells incorporating BrdU was significantly elevated by desulfated chondroitin sulfate in the presence of fibroblast growth factor-2 (FGF-2 or basic FGF) and depressed by heparin in the presence of either FGF-1 or acidic FGF or FGF-2.	Chondroitin Sulfates	84-103	fibroblast growth factor 2	Rattus norvegicus	151-156
8910487-8	1996	In CS from old cartilage, sulfation at C-6 of GalNAc is a major feature from the nonreducing end down to approximately positions 4 and 5 from the linkage region, where GalNAc 4-O-sulfate is common.	Chondroitin Sulfates	3-5	complement C6	Homo sapiens	39-42
8910306-8	1996	Binding of N-CAM to the immobilized neurocan core protein could be inhibited with all recombinant fragments containing chondroitin sulfate or major parts of the mucin-like central region of neurocan.	Chondroitin Sulfates	119-138	neural cell adhesion molecule 1	Homo sapiens	11-16
9067256-7	1996	Glycosaminoglycans such as chondroitin sulfate, dermatan sulfate and a chondroitin polysulfate, interacted with myeloblastin as non-essential activators in the presence of peptide substrates (activation up to a 6.7-fold factor) and as partial inhibitors (about 50% inhibition at saturation) in the presence of elastin.	Chondroitin Sulfates	27-46	proteinase 3	Homo sapiens	112-124
8918906-8	1996	During later stages of healing, chondroitin sulfate expression was selective for areas in which ECM remodeling was active; in these specific areas elastin staining reappeared.	Chondroitin Sulfates	32-51	LOC100620140	Sus scrofa	147-154
8824283-10	1996	Heparin and chondroitin 6-sulfate increased phospholipase A2 activity on low density lipoproteins up to 4-fold at 100 microM, whereas heparan sulfate had no effect.	Chondroitin Sulfates	12-33	phospholipase A2 group IB	Homo sapiens	44-60
8828497-5	1996	We evaluated this hypothesis by binding 125I-labeled recombinant glycosylated human IGFBP-3 to human fetal skin fibroblasts (GM-10) and to C6 rat glioma cells at 12 C. Heparin inhibited [125I]IGFBP-3 binding more effectively than chondroitin sulfate and dextran sulfate.	Chondroitin Sulfates	230-249	insulin like growth factor binding protein 3	Homo sapiens	84-91
8798631-9	1996	Assays with purified reagents show that the fucosylated chondroitin sulfate can potentiate the thrombin inhibition activity of both antithrombin and heparin cofactor II.	Chondroitin Sulfates	56-75	coagulation factor II, thrombin	Homo sapiens	95-103
8798631-9	1996	Assays with purified reagents show that the fucosylated chondroitin sulfate can potentiate the thrombin inhibition activity of both antithrombin and heparin cofactor II.	Chondroitin Sulfates	56-75	serpin family C member 1	Homo sapiens	132-144
9067256-7	1996	Glycosaminoglycans such as chondroitin sulfate, dermatan sulfate and a chondroitin polysulfate, interacted with myeloblastin as non-essential activators in the presence of peptide substrates (activation up to a 6.7-fold factor) and as partial inhibitors (about 50% inhibition at saturation) in the presence of elastin.	Chondroitin Sulfates	27-46	elastin	Homo sapiens	310-317
9067256-7	1996	Glycosaminoglycans such as chondroitin sulfate, dermatan sulfate and a chondroitin polysulfate, interacted with myeloblastin as non-essential activators in the presence of peptide substrates (activation up to a 6.7-fold factor) and as partial inhibitors (about 50% inhibition at saturation) in the presence of elastin.	Chondroitin Sulfates	71-94	proteinase 3	Homo sapiens	112-124
9067256-7	1996	Glycosaminoglycans such as chondroitin sulfate, dermatan sulfate and a chondroitin polysulfate, interacted with myeloblastin as non-essential activators in the presence of peptide substrates (activation up to a 6.7-fold factor) and as partial inhibitors (about 50% inhibition at saturation) in the presence of elastin.	Chondroitin Sulfates	71-94	elastin	Homo sapiens	310-317
8752156-0	1996	2B1 antigen characteristically expressed on extracellular matrices of human malignant tumors is a large chondroitin sulfate proteoglycan, PG-M/versican.	Chondroitin Sulfates	104-123	serine (or cysteine) peptidase inhibitor, clade A, member 3D, pseudogene	Mus musculus	0-3
8752156-5	1996	We characterized the 2B1 antigen isolated from the conditioned medium of human malignant fibrous histiocytoma and found that immunological and biochemical properties are identical to those of a large chondroitin sulfate proteoglycan, PG-M/versican.	Chondroitin Sulfates	200-219	serine (or cysteine) peptidase inhibitor, clade A, member 3D, pseudogene	Mus musculus	21-24
8702628-6	1996	Upon formation of the apparent covalent linkage between heavy chains and HA in culture medium, the light chain (bikunin) is concomitantly released into the medium as a complex with chondroitin sulfate moieties of inter-alpha-inhibitor supporting the possibility that HA may replace the chondroitin sulfate linkage to the heavy chains.	Chondroitin Sulfates	181-200	alpha-1-microglobulin/bikunin precursor	Homo sapiens	112-119
8702651-2	1996	Biglycan is a small chondroitin sulfate proteoglycan found in many tissues and is structurally related to decorin, fibromodulin, and lumican.	Chondroitin Sulfates	20-39	biglycan	Homo sapiens	0-8
8702651-7	1996	Glycoforms of biglycan were separated by imidazole gradient elution, under non-denaturing conditions, and comprised: a large proteoglycan form substituted with two chondroitin sulfate chains of molecular mass approximately 34 kDa (HT-1080 cells) or approximately 40 kDa (UMR106 cells); a small proteoglycan form substituted with two chondroitin sulfate chains with a median molecular mass approximately 28 kDa; and a core protein form secreted devoid of glycosaminoglycan chains.	Chondroitin Sulfates	164-183	biglycan	Homo sapiens	14-22
8702651-7	1996	Glycoforms of biglycan were separated by imidazole gradient elution, under non-denaturing conditions, and comprised: a large proteoglycan form substituted with two chondroitin sulfate chains of molecular mass approximately 34 kDa (HT-1080 cells) or approximately 40 kDa (UMR106 cells); a small proteoglycan form substituted with two chondroitin sulfate chains with a median molecular mass approximately 28 kDa; and a core protein form secreted devoid of glycosaminoglycan chains.	Chondroitin Sulfates	333-352	biglycan	Homo sapiens	14-22
8702927-1	1996	A major chondroitin sulfate proteoglycan in the brain, 6B4 proteoglycan/phosphacan, corresponds to the extracellular region of a receptor-like protein-tyrosine phosphatase, PTPzeta/RPTPbeta.	Chondroitin Sulfates	8-27	protein tyrosine phosphatase, receptor type Z1	Rattus norvegicus	55-71
8702927-1	1996	A major chondroitin sulfate proteoglycan in the brain, 6B4 proteoglycan/phosphacan, corresponds to the extracellular region of a receptor-like protein-tyrosine phosphatase, PTPzeta/RPTPbeta.	Chondroitin Sulfates	8-27	protein tyrosine phosphatase, receptor type Z1	Rattus norvegicus	173-180
8702927-1	1996	A major chondroitin sulfate proteoglycan in the brain, 6B4 proteoglycan/phosphacan, corresponds to the extracellular region of a receptor-like protein-tyrosine phosphatase, PTPzeta/RPTPbeta.	Chondroitin Sulfates	8-27	protein tyrosine phosphatase, receptor type Z1	Rattus norvegicus	181-189
8702927-12	1996	These results suggested that interaction between 6B4 proteoglycan and pleiotrophin is required for the action of pleiotrophin, and chondroitin sulfate chains on 6B4 proteoglycan play regulatory roles in its binding.	Chondroitin Sulfates	131-150	protein tyrosine phosphatase, receptor type Z1	Rattus norvegicus	49-65
8702927-12	1996	These results suggested that interaction between 6B4 proteoglycan and pleiotrophin is required for the action of pleiotrophin, and chondroitin sulfate chains on 6B4 proteoglycan play regulatory roles in its binding.	Chondroitin Sulfates	131-150	pleiotrophin	Rattus norvegicus	70-82
8702927-12	1996	These results suggested that interaction between 6B4 proteoglycan and pleiotrophin is required for the action of pleiotrophin, and chondroitin sulfate chains on 6B4 proteoglycan play regulatory roles in its binding.	Chondroitin Sulfates	131-150	protein tyrosine phosphatase, receptor type Z1	Rattus norvegicus	161-177
8710849-1	1996	Mucopolysaccharidosis VI (MPS VI) is a lysosomal storage disease with autosomal recessive inheritance caused by a deficiency of the enzyme arylsulfatase B (ASB), which is involved in degradation of dermatan sulfate and chondroitin 4-sulfate.	Chondroitin Sulfates	219-240	arylsulfatase B	Mus musculus	156-159
8702628-6	1996	Upon formation of the apparent covalent linkage between heavy chains and HA in culture medium, the light chain (bikunin) is concomitantly released into the medium as a complex with chondroitin sulfate moieties of inter-alpha-inhibitor supporting the possibility that HA may replace the chondroitin sulfate linkage to the heavy chains.	Chondroitin Sulfates	286-305	alpha-1-microglobulin/bikunin precursor	Homo sapiens	112-119
8702628-7	1996	We speculate that a factor(s) secreted by granulosa cells within the follicle may catalyze a transesterification reaction resulting in an exchange of chondroitin sulfate with HA at the heavy chain/chondroitin sulfate junction followed by release of chondroitin sulfate-bikunin into the follicular fluid.	Chondroitin Sulfates	150-169	alpha-1-microglobulin/bikunin precursor	Homo sapiens	269-276
8856499-3	1996	To identify changes in the organization of actin filaments and microtubules that occur as growth cones turn, we used time-lapse phase contrast videomicroscopy to observe embryonic chick dorsal root ganglion neuronal growth cones at a substratum border between fibronectin and chondroitin sulfate proteoglycan, in the presence and absence of cytochalasin B.	Chondroitin Sulfates	276-295	actin, beta	Gallus gallus	43-48
8856499-8	1996	We conclude that actin filament bundles are required for microtubule reorientation and growth cone turning to avoid chondroitin sulfate proteoglycan.	Chondroitin Sulfates	116-135	actin, beta	Gallus gallus	17-22
8663259-1	1996	Neurocan, a nervous tissue-specific chondroitin sulfate proteoglycan of the aggrecan family which has been shown to interact with neural cell adhesion molecules and tenascin, could be visualized by rotary shadowing electron microscopy as two globular domains interconnected by an extended flexible filament of 60-90 nm.	Chondroitin Sulfates	36-55	tenascin C	Homo sapiens	165-173
8639862-5	1996	The adhesion of sickle RBCs to immobilized TSP was inhibited by the anionic polysaccharides high molecular weight (MW) dextran sulfate and chondroitin sulfate A, but not other anionic polysaccharides of similar structure and/or charge density.	Chondroitin Sulfates	139-160	thrombospondin 1	Homo sapiens	43-46
8663515-4	1996	The contribution of chondroitin sulfate chains to the binding of neurocan and phosphacan to TAG-1/axonin-1 is therefore the opposite of that previously observed for their binding to two other Ig-superfamily neural cell adhesion molecules, Ng-CAM/L1 and N-CAM.	Chondroitin Sulfates	20-39	protein tyrosine phosphatase receptor type Z1	Homo sapiens	78-88
8663515-4	1996	The contribution of chondroitin sulfate chains to the binding of neurocan and phosphacan to TAG-1/axonin-1 is therefore the opposite of that previously observed for their binding to two other Ig-superfamily neural cell adhesion molecules, Ng-CAM/L1 and N-CAM.	Chondroitin Sulfates	20-39	contactin 2	Homo sapiens	92-97
8647947-7	1996	Endothelial cell adhesion and migration on fibrinogen were inhibited by both beta-d xyloside and after cleavage of chondroitin sulfate from the core protein by chondroitinase ABC.	Chondroitin Sulfates	115-134	fibrinogen beta chain	Homo sapiens	43-53
8690466-0	1996	Stem cell factor-dependent human cord blood derived mast cells express alpha- and beta-tryptase, heparin and chondroitin sulphate.	Chondroitin Sulfates	109-129	KIT ligand	Homo sapiens	0-16
8752662-7	1996	12-O-Tetradecanoylphorbol 13-acetate increases the size of the chondroitin sulfate chain(s) attached to CD44 but not the proportion of CD44 molecules that carry chondroitin sulfate.	Chondroitin Sulfates	63-82	CD44 molecule (Indian blood group)	Homo sapiens	104-108
8744012-1	1996	Recently, it has been reported that hypochlorous acid (HOCl), a special product of neutrophil myeloperoxidase, degrades N-acetyl groups of N-acetylglucosamine, chondroitin sulfate, hyaluronic acid, and minced articular cartilage via a transient product to acetate.	Chondroitin Sulfates	160-179	myeloperoxidase	Homo sapiens	94-109
8613703-1	1996	The major proteoglycan in macrophages and platelets is the chondroitin sulphate proteoglycan serglycin.	Chondroitin Sulfates	59-79	serglycin	Homo sapiens	93-102
8791281-1	1996	In anchorage-dependent (AD) cultures of the outer cell population (OCP) from neonatal rat calvaria, transforming growth factor-beta 1 (TGF-beta) specifically upregulated the synthesis of chondroitin sulfate (CS) proteoglycan (PG) and uncoupled the inhibitory effect of increasing cell density on CS PG synthesis (reference #30).	Chondroitin Sulfates	187-206	transforming growth factor, beta 1	Rattus norvegicus	100-133
8791281-1	1996	In anchorage-dependent (AD) cultures of the outer cell population (OCP) from neonatal rat calvaria, transforming growth factor-beta 1 (TGF-beta) specifically upregulated the synthesis of chondroitin sulfate (CS) proteoglycan (PG) and uncoupled the inhibitory effect of increasing cell density on CS PG synthesis (reference #30).	Chondroitin Sulfates	187-206	transforming growth factor, beta 1	Rattus norvegicus	135-143
8791281-1	1996	In anchorage-dependent (AD) cultures of the outer cell population (OCP) from neonatal rat calvaria, transforming growth factor-beta 1 (TGF-beta) specifically upregulated the synthesis of chondroitin sulfate (CS) proteoglycan (PG) and uncoupled the inhibitory effect of increasing cell density on CS PG synthesis (reference #30).	Chondroitin Sulfates	208-210	transforming growth factor, beta 1	Rattus norvegicus	100-133
8791281-1	1996	In anchorage-dependent (AD) cultures of the outer cell population (OCP) from neonatal rat calvaria, transforming growth factor-beta 1 (TGF-beta) specifically upregulated the synthesis of chondroitin sulfate (CS) proteoglycan (PG) and uncoupled the inhibitory effect of increasing cell density on CS PG synthesis (reference #30).	Chondroitin Sulfates	208-210	transforming growth factor, beta 1	Rattus norvegicus	135-143
8791281-1	1996	In anchorage-dependent (AD) cultures of the outer cell population (OCP) from neonatal rat calvaria, transforming growth factor-beta 1 (TGF-beta) specifically upregulated the synthesis of chondroitin sulfate (CS) proteoglycan (PG) and uncoupled the inhibitory effect of increasing cell density on CS PG synthesis (reference #30).	Chondroitin Sulfates	296-298	transforming growth factor, beta 1	Rattus norvegicus	100-133
8791281-1	1996	In anchorage-dependent (AD) cultures of the outer cell population (OCP) from neonatal rat calvaria, transforming growth factor-beta 1 (TGF-beta) specifically upregulated the synthesis of chondroitin sulfate (CS) proteoglycan (PG) and uncoupled the inhibitory effect of increasing cell density on CS PG synthesis (reference #30).	Chondroitin Sulfates	296-298	transforming growth factor, beta 1	Rattus norvegicus	135-143
8791281-3	1996	Although addition of TGF-beta alone stimulated net synthesis of HA and CS in both AD and anchorage-independent (AI) cultures, significant alterations of basal and TGF-beta-stimulated GAG synthesis by exogenous GAGs were observed only in AI cultures.	Chondroitin Sulfates	71-73	transforming growth factor, beta 1	Rattus norvegicus	21-29
8791281-5	1996	Also, the addition of HA markedly potentiated the stimulation by TGF-beta of HA and CS synthesis as did heparan sulfate (HS) for CS and DS synthesis.	Chondroitin Sulfates	84-86	transforming growth factor, beta 1	Rattus norvegicus	65-73
8791281-6	1996	H suppressed the stimulation of the synthesis of HA, CS and DS by TGF-beta.	Chondroitin Sulfates	53-55	transforming growth factor, beta 1	Rattus norvegicus	66-74
8807193-4	1996	Enzymatic degradation of chondroitin sulfates decreased adhesion in agrin-containing membrane fractions but increased adhesion if the agrin had previously been removed by immunoprecipitation, suggesting that interactions between heparan sulfate and chondroitin sulfate proteoglycans have important influences on adhesion.	Chondroitin Sulfates	25-45	agrin	Gallus gallus	68-73
8807193-4	1996	Enzymatic degradation of chondroitin sulfates decreased adhesion in agrin-containing membrane fractions but increased adhesion if the agrin had previously been removed by immunoprecipitation, suggesting that interactions between heparan sulfate and chondroitin sulfate proteoglycans have important influences on adhesion.	Chondroitin Sulfates	25-45	agrin	Gallus gallus	134-139
8807193-4	1996	Enzymatic degradation of chondroitin sulfates decreased adhesion in agrin-containing membrane fractions but increased adhesion if the agrin had previously been removed by immunoprecipitation, suggesting that interactions between heparan sulfate and chondroitin sulfate proteoglycans have important influences on adhesion.	Chondroitin Sulfates	25-44	agrin	Gallus gallus	68-73
8807193-4	1996	Enzymatic degradation of chondroitin sulfates decreased adhesion in agrin-containing membrane fractions but increased adhesion if the agrin had previously been removed by immunoprecipitation, suggesting that interactions between heparan sulfate and chondroitin sulfate proteoglycans have important influences on adhesion.	Chondroitin Sulfates	25-44	agrin	Gallus gallus	134-139
8807193-5	1996	Our experiments support the view that NCAM can interact with multiple, but not with all, heparan sulfate and chondroitin sulfate proteoglycans in chick brain membranes in both positive and negative ways to influence cell adhesion.	Chondroitin Sulfates	109-128	neural cell adhesion molecule 1	Gallus gallus	38-42
8613703-4	1996	Antibodies against human macrophage inflammatory protein-1 alpha (MIP-1 alpha) precipitated a 14-kDa 35S-methionine-labeled protein among the chondroitin sulfate binding proteins secreted from the macrophage-like U937 cells after stimulation.	Chondroitin Sulfates	142-161	C-C motif chemokine ligand 3	Homo sapiens	25-64
8613703-4	1996	Antibodies against human macrophage inflammatory protein-1 alpha (MIP-1 alpha) precipitated a 14-kDa 35S-methionine-labeled protein among the chondroitin sulfate binding proteins secreted from the macrophage-like U937 cells after stimulation.	Chondroitin Sulfates	142-161	C-C motif chemokine ligand 3	Homo sapiens	66-77
8613703-10	1996	Chondroitin sulfate-Sepharose was shown to be equally efficient in retaining PF4 from platelet extracts as serglycin-Sepharose indicating that the glycosaminoglycan chains mediate the binding to PF4 in the intact proteoglycan molecule.	Chondroitin Sulfates	0-19	platelet factor 4	Homo sapiens	77-80
8613703-10	1996	Chondroitin sulfate-Sepharose was shown to be equally efficient in retaining PF4 from platelet extracts as serglycin-Sepharose indicating that the glycosaminoglycan chains mediate the binding to PF4 in the intact proteoglycan molecule.	Chondroitin Sulfates	0-19	platelet factor 4	Homo sapiens	195-198
8635505-1	1996	We have previously shown that free galactosugars and N-acetylgalactosamine glycosaminoglycans, e.g., chondroitin sulfate (CS), release the 67-kDa elastin binding protein (EBP) from arterial smooth muscle cell (SMC) surfaces.	Chondroitin Sulfates	101-120	EBP cholestenol delta-isomerase	Homo sapiens	146-169
8635505-1	1996	We have previously shown that free galactosugars and N-acetylgalactosamine glycosaminoglycans, e.g., chondroitin sulfate (CS), release the 67-kDa elastin binding protein (EBP) from arterial smooth muscle cell (SMC) surfaces.	Chondroitin Sulfates	101-120	EBP cholestenol delta-isomerase	Homo sapiens	171-174
8635505-1	1996	We have previously shown that free galactosugars and N-acetylgalactosamine glycosaminoglycans, e.g., chondroitin sulfate (CS), release the 67-kDa elastin binding protein (EBP) from arterial smooth muscle cell (SMC) surfaces.	Chondroitin Sulfates	122-124	EBP cholestenol delta-isomerase	Homo sapiens	146-169
8635505-1	1996	We have previously shown that free galactosugars and N-acetylgalactosamine glycosaminoglycans, e.g., chondroitin sulfate (CS), release the 67-kDa elastin binding protein (EBP) from arterial smooth muscle cell (SMC) surfaces.	Chondroitin Sulfates	122-124	EBP cholestenol delta-isomerase	Homo sapiens	171-174
8635505-4	1996	We showed that CS-induced shedding of the EBP or internalization of this receptor after saturation with elastin-derived peptides (kappa-elastin, kappa-El) stimulated fibronectin production in cultures of coronary artery SMC to a level observed with recombinant interleukin (IL)-1beta.	Chondroitin Sulfates	15-17	EBP cholestenol delta-isomerase	Homo sapiens	42-45
8635505-4	1996	We showed that CS-induced shedding of the EBP or internalization of this receptor after saturation with elastin-derived peptides (kappa-elastin, kappa-El) stimulated fibronectin production in cultures of coronary artery SMC to a level observed with recombinant interleukin (IL)-1beta.	Chondroitin Sulfates	15-17	elastin	Homo sapiens	104-111
8635505-4	1996	We showed that CS-induced shedding of the EBP or internalization of this receptor after saturation with elastin-derived peptides (kappa-elastin, kappa-El) stimulated fibronectin production in cultures of coronary artery SMC to a level observed with recombinant interleukin (IL)-1beta.	Chondroitin Sulfates	15-17	elastin	Homo sapiens	136-143
8635505-4	1996	We showed that CS-induced shedding of the EBP or internalization of this receptor after saturation with elastin-derived peptides (kappa-elastin, kappa-El) stimulated fibronectin production in cultures of coronary artery SMC to a level observed with recombinant interleukin (IL)-1beta.	Chondroitin Sulfates	15-17	fibronectin 1	Homo sapiens	166-177
8635505-4	1996	We showed that CS-induced shedding of the EBP or internalization of this receptor after saturation with elastin-derived peptides (kappa-elastin, kappa-El) stimulated fibronectin production in cultures of coronary artery SMC to a level observed with recombinant interleukin (IL)-1beta.	Chondroitin Sulfates	15-17	interleukin 1 beta	Homo sapiens	261-283
8635505-6	1996	Immunohistochemistry showed that EBP and IL-1 receptor type I codistributed on surfaces of unstimulated coronary artery SMC, while CS- and kappa-El-dependent removal of EBP from the cell surface increased binding of radiolabeled IL-1beta to CA SMC.	Chondroitin Sulfates	131-133	EBP cholestenol delta-isomerase	Homo sapiens	169-172
8562939-0	1996	Human homologue of the rat chondroitin sulfate proteoglycan, NG2, detected by monoclonal antibody 7.1, identifies childhood acute lymphoblastic leukemias with t(4;11)(q21;q23) or t(11;19)(q23;p13) and MLL gene rearrangements.	Chondroitin Sulfates	27-46	chondroitin sulfate proteoglycan 4	Rattus norvegicus	61-64
8656041-3	1996	We found that binding of iodine 125-labeled PF4 to HEL cells was inhibited by heparin, heparan sulfate, and dermatan sulfate and to a smaller extent by chondroitin sulfate.	Chondroitin Sulfates	152-171	platelet factor 4	Homo sapiens	44-47
8606238-1	1996	We present a case with acute radiation-induced hepatic injury using chondroitin sulfate iron colloid (CSIS)-enhanced MRI.	Chondroitin Sulfates	68-87	platelet derived growth factor subunit B	Homo sapiens	102-106
8660298-2	1996	In addition, a number of other acidic oligosaccharides (for example heparin or chondroitin sulphate) or glycolipids (for example sulphatides) bind to L-selectin independent of cations.	Chondroitin Sulfates	79-99	selectin L	Homo sapiens	150-160
8625816-1	1996	6B4 proteoglycan/phosphacan is one of the major phosphate-buffered saline-soluble chondroitin sulfate proteoglycans of the brain.	Chondroitin Sulfates	82-101	protein tyrosine phosphatase receptor type Z1	Homo sapiens	17-27
8600153-10	1996	Chondroitin sulfate, an inhibitor of STE-induced elastase activity, attenuated the release of bFGF.	Chondroitin Sulfates	0-19	fibroblast growth factor 2	Homo sapiens	94-98
8562939-0	1996	Human homologue of the rat chondroitin sulfate proteoglycan, NG2, detected by monoclonal antibody 7.1, identifies childhood acute lymphoblastic leukemias with t(4;11)(q21;q23) or t(11;19)(q23;p13) and MLL gene rearrangements.	Chondroitin Sulfates	27-46	H3 histone pseudogene 6	Homo sapiens	192-195
8562939-0	1996	Human homologue of the rat chondroitin sulfate proteoglycan, NG2, detected by monoclonal antibody 7.1, identifies childhood acute lymphoblastic leukemias with t(4;11)(q21;q23) or t(11;19)(q23;p13) and MLL gene rearrangements.	Chondroitin Sulfates	27-46	lysine methyltransferase 2A	Rattus norvegicus	201-204
8562939-1	1996	Monoclonal antibody 7.1, which recognizes the chondroitin sulfate proteoglycan molecule NG2, was used to screen prospectively blast cells from 104 consecutive children at initial presentation with acute lymphoblastic leukemia (ALL).	Chondroitin Sulfates	46-65	chondroitin sulfate proteoglycan 4	Homo sapiens	88-91
8714520-1	1996	Previous studies on the NG2 chondroitin sulfate proteoglycan have shown that NG2 is expressed on A2B5-positive O2A progenitor cells, which are known to respond to platelet-derived growth factor (PDGF).	Chondroitin Sulfates	28-47	chondroitin sulfate proteoglycan 4	Rattus norvegicus	24-27
8714520-1	1996	Previous studies on the NG2 chondroitin sulfate proteoglycan have shown that NG2 is expressed on A2B5-positive O2A progenitor cells, which are known to respond to platelet-derived growth factor (PDGF).	Chondroitin Sulfates	28-47	chondroitin sulfate proteoglycan 4	Rattus norvegicus	77-80
7592978-0	1995	Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms.	Chondroitin Sulfates	12-31	brevican	Rattus norvegicus	0-8
9117258-1	1996	In this review, we discuss the properties of the NG2 chondroitin sulfate proteoglycan, a structurally unique, integral membrane proteoglycan that is found on the surfaces of several different types of immature cells.	Chondroitin Sulfates	53-72	chondroitin sulfate proteoglycan 4	Homo sapiens	49-52
7592931-0	1995	Neuroglycan C, a novel membrane-spanning chondroitin sulfate proteoglycan that is restricted to the brain.	Chondroitin Sulfates	41-60	chondroitin sulfate proteoglycan 5	Rattus norvegicus	0-13
8838671-6	1996	Addition of heparin and heparan sulfate reversed the collagen IV mRNA induction whereas hyaluronic acid and chondroitin sulfate enhanced fibronectin and collagenase transcripts.	Chondroitin Sulfates	108-127	fibronectin 1	Homo sapiens	137-148
7487873-5	1995	Although bFGF and/or TGF-beta 1 induced a similar stimulation in cell-surface chondroitin sulphate/dermatan sulphate and heparan sulphate (HS) proteoglycan synthesis, only the turnover of HS proteoglycans was increased.	Chondroitin Sulfates	78-98	transforming growth factor beta 1	Sus scrofa	21-31
7595522-0	1995	Chondroitin sulfate and chondroitin/keratan sulfate proteoglycans of nervous tissue: developmental changes of neurocan and phosphacan.	Chondroitin Sulfates	0-19	neurocan	Rattus norvegicus	110-118
7670961-5	1995	IFN-gamma binding to ECM was reduced by increasing concentrations of chondroitin-6-sulfate.	Chondroitin Sulfates	69-90	interferon gamma	Homo sapiens	0-9
7670961-11	1995	These results suggest a role for chondroitin-sulfate PGs in immobilizing IFN-gamma in the ECM compartment and enhancing the cellular response to IFN-gamma.	Chondroitin Sulfates	33-52	interferon gamma	Homo sapiens	145-154
7670961-8	1995	The binding to chondroitin-sulfate PGs was confirmed by affinity chromatography of isolated [35S]chondroitin-sulfate PGs from ECM and cell-culture medium on immobilized IFN-gamma.	Chondroitin Sulfates	15-34	interferon gamma	Homo sapiens	169-178
7670961-8	1995	The binding to chondroitin-sulfate PGs was confirmed by affinity chromatography of isolated [35S]chondroitin-sulfate PGs from ECM and cell-culture medium on immobilized IFN-gamma.	Chondroitin Sulfates	97-116	interferon gamma	Homo sapiens	169-178
7670961-11	1995	These results suggest a role for chondroitin-sulfate PGs in immobilizing IFN-gamma in the ECM compartment and enhancing the cellular response to IFN-gamma.	Chondroitin Sulfates	33-52	interferon gamma	Homo sapiens	73-82
7477903-1	1995	A large brain-specific chondroitin sulfate proteoglycan, identified with monoclonal antibody 6B4 (6B4 proteoglycan/phosphacan), was isolated from rat brain.	Chondroitin Sulfates	23-42	protein tyrosine phosphatase, receptor type Z1	Rattus norvegicus	98-114
8519429-0	1995	Facilitation of learning following injection of the chondroitin sulfate proteoglycan biglycan into the vicinity of the nucleus basalis magnocellularis.	Chondroitin Sulfates	52-71	biglycan	Rattus norvegicus	85-93
7544118-5	1995	Stimulation of the cells with TGF-beta 1 increased the length of the chondroitin sulphate (CS) chains on CD44 (approximately 1.6-fold).	Chondroitin Sulfates	69-89	transforming growth factor beta 1	Homo sapiens	30-40
7544118-5	1995	Stimulation of the cells with TGF-beta 1 increased the length of the chondroitin sulphate (CS) chains on CD44 (approximately 1.6-fold).	Chondroitin Sulfates	69-89	CD44 molecule (Indian blood group)	Homo sapiens	105-109
7544118-5	1995	Stimulation of the cells with TGF-beta 1 increased the length of the chondroitin sulphate (CS) chains on CD44 (approximately 1.6-fold).	Chondroitin Sulfates	91-93	transforming growth factor beta 1	Homo sapiens	30-40
7544118-5	1995	Stimulation of the cells with TGF-beta 1 increased the length of the chondroitin sulphate (CS) chains on CD44 (approximately 1.6-fold).	Chondroitin Sulfates	91-93	CD44 molecule (Indian blood group)	Homo sapiens	105-109
7544118-6	1995	bFGF, administered solely, also increased the length of the CS chains on CD44 (approximately 1.4-fold), whereas the combination of TGF-beta 1 + bFGF nearly doubled both the length and the number of the CS chains on CD44.	Chondroitin Sulfates	60-62	fibroblast growth factor 2	Homo sapiens	0-4
7544118-6	1995	bFGF, administered solely, also increased the length of the CS chains on CD44 (approximately 1.4-fold), whereas the combination of TGF-beta 1 + bFGF nearly doubled both the length and the number of the CS chains on CD44.	Chondroitin Sulfates	60-62	CD44 molecule (Indian blood group)	Homo sapiens	73-77
7544118-6	1995	bFGF, administered solely, also increased the length of the CS chains on CD44 (approximately 1.4-fold), whereas the combination of TGF-beta 1 + bFGF nearly doubled both the length and the number of the CS chains on CD44.	Chondroitin Sulfates	202-204	transforming growth factor beta 1	Homo sapiens	131-141
7544118-6	1995	bFGF, administered solely, also increased the length of the CS chains on CD44 (approximately 1.4-fold), whereas the combination of TGF-beta 1 + bFGF nearly doubled both the length and the number of the CS chains on CD44.	Chondroitin Sulfates	202-204	fibroblast growth factor 2	Homo sapiens	144-148
7544118-9	1995	TGF-beta 1, alone or in combination with bFGF, also stimulated the CS content of syndecan-1, but none of the other syndecans was significantly affected by any of the factors or combinations tested.	Chondroitin Sulfates	67-69	transforming growth factor beta 1	Homo sapiens	0-10
7544118-9	1995	TGF-beta 1, alone or in combination with bFGF, also stimulated the CS content of syndecan-1, but none of the other syndecans was significantly affected by any of the factors or combinations tested.	Chondroitin Sulfates	67-69	fibroblast growth factor 2	Homo sapiens	41-45
7544118-9	1995	TGF-beta 1, alone or in combination with bFGF, also stimulated the CS content of syndecan-1, but none of the other syndecans was significantly affected by any of the factors or combinations tested.	Chondroitin Sulfates	67-69	syndecan 1	Homo sapiens	81-91
7608185-4	1995	The avian Cdc37 binds hyaluronan, chondroitin sulfate and heparin in vitro, and both isoforms contain glycosaminoglycan-binding motifs previously described in several hyaluronan-binding proteins.	Chondroitin Sulfates	34-53	cell division cycle 37	Gallus gallus	10-15
7615164-8	1995	In addition to protein-protein interactions, thrombomodulin has a covalently associated chondroitin sulfate moiety.	Chondroitin Sulfates	88-107	thrombomodulin	Homo sapiens	45-59
7615164-9	1995	Chondroitin sulfate binds to a basic surface on thrombin that is also involved in heparin interaction.	Chondroitin Sulfates	0-19	coagulation factor II, thrombin	Homo sapiens	48-56
7615164-10	1995	The chondroitin sulfate enhances the affinity of thrombin for thrombomodulin approximately 10- to 20-fold, making thrombomodulin a more potent inhibitor of coagulation, altering thrombin"s conformation and specificity, and accelerating thrombin inhibition by the serpin, antithrombin.	Chondroitin Sulfates	4-23	coagulation factor II, thrombin	Homo sapiens	49-57
7615164-10	1995	The chondroitin sulfate enhances the affinity of thrombin for thrombomodulin approximately 10- to 20-fold, making thrombomodulin a more potent inhibitor of coagulation, altering thrombin"s conformation and specificity, and accelerating thrombin inhibition by the serpin, antithrombin.	Chondroitin Sulfates	4-23	thrombomodulin	Homo sapiens	62-76
7615164-10	1995	The chondroitin sulfate enhances the affinity of thrombin for thrombomodulin approximately 10- to 20-fold, making thrombomodulin a more potent inhibitor of coagulation, altering thrombin"s conformation and specificity, and accelerating thrombin inhibition by the serpin, antithrombin.	Chondroitin Sulfates	4-23	thrombomodulin	Homo sapiens	114-128
7615164-10	1995	The chondroitin sulfate enhances the affinity of thrombin for thrombomodulin approximately 10- to 20-fold, making thrombomodulin a more potent inhibitor of coagulation, altering thrombin"s conformation and specificity, and accelerating thrombin inhibition by the serpin, antithrombin.	Chondroitin Sulfates	4-23	coagulation factor II, thrombin	Homo sapiens	178-186
7615164-10	1995	The chondroitin sulfate enhances the affinity of thrombin for thrombomodulin approximately 10- to 20-fold, making thrombomodulin a more potent inhibitor of coagulation, altering thrombin"s conformation and specificity, and accelerating thrombin inhibition by the serpin, antithrombin.	Chondroitin Sulfates	4-23	coagulation factor II, thrombin	Homo sapiens	178-186
7615164-10	1995	The chondroitin sulfate enhances the affinity of thrombin for thrombomodulin approximately 10- to 20-fold, making thrombomodulin a more potent inhibitor of coagulation, altering thrombin"s conformation and specificity, and accelerating thrombin inhibition by the serpin, antithrombin.	Chondroitin Sulfates	4-23	serpin family C member 1	Homo sapiens	271-283
8572610-5	1995	HPLC analysis of chondroitinase AC and ABC digests showed a marked increase in delta di-6S and delta di-OS disaccharides in tumor chondroitin sulfate, revealing significant alterations on the sulfation pattern.	Chondroitin Sulfates	130-149	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	39-42
7616233-6	1995	Extensive mapping with epitope-specific antibodies suggested that a CS chain is attached within or proximal to the A beta sequence of APP.	Chondroitin Sulfates	68-70	amyloid beta (A4) precursor protein	Mus musculus	115-121
7790815-4	1995	Parasitized cells bound to Chinese hamster ovary (CHO) cells and C32 melanoma cells in a chondroitin sulfate-dependent manner, whereas glycosylation mutants lacking chondroitin sulfate A (CSA) supported little or no binding.	Chondroitin Sulfates	165-186	chorionic somatomammotropin hormone 1	Homo sapiens	188-191
7775582-5	1995	A proteoglycan with a 250-kD core protein following removal of chondroitin sulfate chains (250-kD PG) inhibits cadherin-mediated adhesion and neurite outgrowth whether presented as the core protein or as a proteoglycan monomer bearing chondroitin sulfate.	Chondroitin Sulfates	63-82	cadherin 2	Gallus gallus	111-119
7797531-8	1995	Furthermore, using CHO mutant cell lines deficient in xylosyltransferase and galactosyltransferase I, which are required for glycosaminoglycan biosynthesis, it is shown that chondroitin sulfate and heparan sulfate are not critical for laminin binding, and indeed are apparently not expressed at all in dystroglycan from CHO cells.	Chondroitin Sulfates	174-193	dystroglycan	Cricetulus griseus	302-314
7586010-3	1995	Treatment with chondroitin sulfate (CS)-PE at 10 micrograms/ml made laminin, fibronectin, vitronectin, and collagens type I-V less adhesive as substrates for cell attachment and inhibited cell spreading on these substrates.	Chondroitin Sulfates	15-34	fibronectin 1	Rattus norvegicus	77-88
7586010-3	1995	Treatment with chondroitin sulfate (CS)-PE at 10 micrograms/ml made laminin, fibronectin, vitronectin, and collagens type I-V less adhesive as substrates for cell attachment and inhibited cell spreading on these substrates.	Chondroitin Sulfates	15-34	vitronectin	Rattus norvegicus	90-101
7586010-3	1995	Treatment with chondroitin sulfate (CS)-PE at 10 micrograms/ml made laminin, fibronectin, vitronectin, and collagens type I-V less adhesive as substrates for cell attachment and inhibited cell spreading on these substrates.	Chondroitin Sulfates	36-38	fibronectin 1	Rattus norvegicus	77-88
7586010-3	1995	Treatment with chondroitin sulfate (CS)-PE at 10 micrograms/ml made laminin, fibronectin, vitronectin, and collagens type I-V less adhesive as substrates for cell attachment and inhibited cell spreading on these substrates.	Chondroitin Sulfates	36-38	vitronectin	Rattus norvegicus	90-101
7796887-8	1995	The remaining RIHB can be removed partially by incubation with heparitinase I or III and completely when the incubation is performed with chondoitinase A, B, C. These results demonstrate that RIHB binds to embryonal chondrocytes and cartilage primarily through proteoglycans of both heparan sulfate and chondroitin sulfate types.	Chondroitin Sulfates	303-322	midkine (neurite growth-promoting factor 2)	Gallus gallus	192-196
7586010-0	1995	Chondroitin sulfate immobilized onto culture substrates modulates DNA synthesis, tyrosine aminotransferase induction, and intercellular communication in primary rat hepatocytes.	Chondroitin Sulfates	0-19	tyrosine aminotransferase	Rattus norvegicus	81-106
7775582-5	1995	A proteoglycan with a 250-kD core protein following removal of chondroitin sulfate chains (250-kD PG) inhibits cadherin-mediated adhesion and neurite outgrowth whether presented as the core protein or as a proteoglycan monomer bearing chondroitin sulfate.	Chondroitin Sulfates	235-254	cadherin 2	Gallus gallus	111-119
7783424-4	1995	Recently, the large chondroitin sulfate (CS) proteoglycan, versican, has been identified in the dermis in association with elastic fibers, and the smaller CS proteoglycan, decorin, has been shown to codistribute with collagen fibers.	Chondroitin Sulfates	41-43	versican	Homo sapiens	59-67
7779869-11	1995	Earlier, syndecan-1 was described as a hybrid proteoglycan containing heparan sulfate/chondroitin sulfate chains which is transcribed by murine B cells at early and late maturation stages.	Chondroitin Sulfates	86-105	syndecan 1	Mus musculus	9-19
7584322-6	1995	Chondroitin-4-sulfate (C4S) was the predominant isomer at all ages in both strains.	Chondroitin Sulfates	23-26	carbohydrate sulfotransferase 11	Mus musculus	0-13
7706380-3	1995	Biol., 28A:176-180) and the protein moiety of low density lipoproteins (LDL; apo B-100) via a similar sequence to chondroitin sulfate (Camejo et al., 1988, Arteriosclerosis Thromb., 8:368-377).	Chondroitin Sulfates	114-133	apolipoprotein B	Homo sapiens	77-86
7626709-1	1995	The genes coding for the core proteins of the small chondroitin sulfate/dermatan sulfate proteoglycans (PGs) biglycan and decorin are both expressed in the adult human testis.	Chondroitin Sulfates	52-71	biglycan	Homo sapiens	109-117
7737970-7	1995	Site-directed mutagenesis combined with immunoreactivity experiments showed that the chondroitin sulfate chain is attached to a serine residue 16 amino acids upstream of the amino terminus of the A beta sequence of APP.	Chondroitin Sulfates	85-104	amyloid beta precursor protein	Homo sapiens	196-202
8968215-5	1995	IgM M proteins that bind to myelin-associated glycoprotein (MAG) have been shown to cause demyelinating peripheral neuropathy; anti-GM1 antibody activity is associated with predominantly motor neuropathy, and anti-sulfatide or chondroitin sulfate antibodies are associated with sensory neuropathy.	Chondroitin Sulfates	227-246	myelin associated glycoprotein	Homo sapiens	60-63
7657726-8	1995	Heparin and chondroitin sulphate were able to inhibit human bone cell attachment to the heparin-binding fragment of fibronectin but had no effect on their attachment to intact fibronectin or the cell-binding region of fibronectin.	Chondroitin Sulfates	12-32	fibronectin 1	Homo sapiens	116-127
7592530-14	1995	Analysis of proteoglycans of the culture medium has shown that most of the medium proteoglycans were keratan sulfate proteoglycan and free keratan sulfate chain (or keratan sulfate chain with a short peptide) during all ages after Day 7, although the major proteoglycan of Day 5 medium was chondroitin sulfate/dermatan sulfate proteoglycan.	Chondroitin Sulfates	290-309	versican	Gallus gallus	82-94
7603617-1	1995	Alzheimer"s beta-amyloid precursor related proteins bearing chondroitin sulfate chains were detected in the conditioned media of primary cultured astrocytes obtained from fetal rat brains by Western blotting using the monoclonal antibody 22C11 against Alzheimer"s beta-amyloid precursor protein (APP), but not in the media of cortical neurons.	Chondroitin Sulfates	60-79	amyloid beta precursor protein	Rattus norvegicus	264-294
7592529-3	1995	Two predominant proteoglycans were identified in the stromal fraction: keratan sulfate proteoglycan and chondroitin sulfate/dermatan sulfate proteoglycan.	Chondroitin Sulfates	104-123	versican	Gallus gallus	16-28
7542529-0	1995	Up-regulation of a chondroitin sulphate epitope during regeneration of mouse sciatic nerve: evidence that the immunoreactive molecules are related to the chondroitin sulphate proteoglycans decorin and versican.	Chondroitin Sulfates	19-39	versican	Mus musculus	201-209
7592530-14	1995	Analysis of proteoglycans of the culture medium has shown that most of the medium proteoglycans were keratan sulfate proteoglycan and free keratan sulfate chain (or keratan sulfate chain with a short peptide) during all ages after Day 7, although the major proteoglycan of Day 5 medium was chondroitin sulfate/dermatan sulfate proteoglycan.	Chondroitin Sulfates	290-309	versican	Gallus gallus	82-94
7531724-6	1994	The gp600 was readily labeled with radioactive sulfate, and treatment of gp600 with chondroitinase ABC or ACII generated a lower molecular weight species (18-22 kDa), suggesting that gp600 consists of a small core protein with chondroitin sulfate glycosaminoglycan side chains.	Chondroitin Sulfates	227-246	serglycin	Mus musculus	73-78
7876916-6	1995	This indicates that the ability of human milk to inhibit gp120 binding to CD4 may be attributed to chondroitin sulfate or to a chondroitin sulfate-like moiety rather than to other components of human milk.	Chondroitin Sulfates	99-118	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	57-62
7876916-6	1995	This indicates that the ability of human milk to inhibit gp120 binding to CD4 may be attributed to chondroitin sulfate or to a chondroitin sulfate-like moiety rather than to other components of human milk.	Chondroitin Sulfates	99-118	CD4 molecule	Homo sapiens	74-77
7876916-6	1995	This indicates that the ability of human milk to inhibit gp120 binding to CD4 may be attributed to chondroitin sulfate or to a chondroitin sulfate-like moiety rather than to other components of human milk.	Chondroitin Sulfates	127-146	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	57-62
7876916-6	1995	This indicates that the ability of human milk to inhibit gp120 binding to CD4 may be attributed to chondroitin sulfate or to a chondroitin sulfate-like moiety rather than to other components of human milk.	Chondroitin Sulfates	127-146	CD4 molecule	Homo sapiens	74-77
7539644-1	1995	This communication is concerned with the binding specificity of the leukocyte-adhesion molecule L-selectin (leukocyte homing receptor) towards structurally defined sulphated oligosaccharides of the blood group Le(a) and Le(x) series, and of the glycosaminoglycan series heparin, chondroitin sulphate and keratan sulphate.	Chondroitin Sulfates	279-299	selectin L	Rattus norvegicus	96-106
7876137-1	1995	We showed previously that the alternative splicing of chondroitin sulfate attachment domains (CS alpha and CS beta) yielded multiforms of the PG-M core protein in mouse.	Chondroitin Sulfates	54-73	heat shock protein 9	Mus musculus	94-102
7876137-1	1995	We showed previously that the alternative splicing of chondroitin sulfate attachment domains (CS alpha and CS beta) yielded multiforms of the PG-M core protein in mouse.	Chondroitin Sulfates	54-73	excision repair cross-complementing rodent repair deficiency, complementation group 6	Mus musculus	107-114
7626416-7	1995	The proteoglycans implicated so far are rich in chondroitin sulphate and thus they may also be insulin-like growth factor I (sulphation factor)-dependent.	Chondroitin Sulfates	48-68	insulin-like growth factor 1	Rattus norvegicus	95-123
7822336-7	1995	Sequencing of cDNA clones for the smaller forms in the adult brain showed that they were different from PG-M(V1) in encoding the second chondroitin sulfate attachment domain (CS alpha) alone.	Chondroitin Sulfates	136-155	versican	Mus musculus	104-111
7822336-8	1995	Occurrence of the PCR products striding over the junction of the first and second chondroitin sulfate attachment domains suggested that a mRNA of 12 kb in size corresponded to a transcript without the alternative splicing (PG-M(V0)).	Chondroitin Sulfates	82-101	versican	Mus musculus	223-230
7833248-1	1995	Haemopoietic progenitor cells (HPC) synthesize and accumulate a single type of membrane-associated chondroitin sulphate proteoglycan (MA-PG), which participates in HPC adhesiveness to fibronectin by interacting with its heparin-binding domain.	Chondroitin Sulfates	99-119	fibronectin 1	Mus musculus	184-195
7750519-3	1995	bFGF-HRP association to adult bovine aortic endothelial (ABAE) cells or baby hamster kidney (BHK) cells was inhibited by a high molar excess of native bFGF, a 2 M NaCl wash at neutral pH, heparin and heparan sulfate, but not by chondroitin 4-sulfate or chondroitin 6-sulfate.	Chondroitin Sulfates	228-249	fibroblast growth factor 2	Bos taurus	0-4
7750519-3	1995	bFGF-HRP association to adult bovine aortic endothelial (ABAE) cells or baby hamster kidney (BHK) cells was inhibited by a high molar excess of native bFGF, a 2 M NaCl wash at neutral pH, heparin and heparan sulfate, but not by chondroitin 4-sulfate or chondroitin 6-sulfate.	Chondroitin Sulfates	253-274	fibroblast growth factor 2	Bos taurus	0-4
8523067-4	1995	We report here preliminary data from Phase I studies of the compartmental administration of the anti-tenascin MAb 81C6 and F(ab2)2 fragments of MAb Me1-14, which recognizes the proteoglycan chondroitin sulfate-associated protein of gliomas and melanomas, to patients with primary central nervous system tumors or tumors metastatic to the central nervous system.	Chondroitin Sulfates	190-209	malic enzyme 1	Homo sapiens	148-151
7961677-0	1994	Expression and binding activity of the carboxyl-terminal portion of the core protein of PG-M, a large chondroitin sulfate proteoglycan.	Chondroitin Sulfates	102-121	versican	Gallus gallus	88-92
7961677-1	1994	PG-M is a large chondroitin sulfate proteoglycan that has been shown to be expressed in the prechondrogenic condensation area of the developing chick limb buds.	Chondroitin Sulfates	16-35	versican	Gallus gallus	0-4
7957667-7	1994	NIH-3T3-derived syndecan contained more chondroitin sulfate than NMuMG-derived syndecan-1, and our results revealed that both heparan sulfate and chondroitin sulfate mediate syndecan-1 binding to laminin.	Chondroitin Sulfates	146-165	syndecan 1	Mus musculus	174-184
7531724-6	1994	The gp600 was readily labeled with radioactive sulfate, and treatment of gp600 with chondroitinase ABC or ACII generated a lower molecular weight species (18-22 kDa), suggesting that gp600 consists of a small core protein with chondroitin sulfate glycosaminoglycan side chains.	Chondroitin Sulfates	227-246	serglycin	Mus musculus	73-78
7531724-7	1994	However, binding of CD44 to glycosaminoglycans such as chondroitin 4-sulfate, chondroitin 6-sulfate, and dermatan sulfate was undetectable, suggesting either that a novel chondroitin-type glycosaminoglycan is recognized by CD44 or that a particular configuration of the glycosaminoglycan is required for recognition by CD44.	Chondroitin Sulfates	55-76	CD44 antigen	Mus musculus	20-24
7818994-4	1994	Urinary CS and HS in CNF did not differ significantly from controls.	Chondroitin Sulfates	8-10	NPHS1 adhesion molecule, nephrin	Homo sapiens	21-24
7929188-4	1994	Human lung carcinoma cells (A549) express more TM(CS+) than primary cells and recombinant TM on human melanoma cells (CHL-1) occurs in two very high molecular weight forms of TM(CS+).	Chondroitin Sulfates	178-181	cell adhesion molecule L1 like	Homo sapiens	118-123
7881183-10	1994	Decorin from bone and articular cartilage, as well as biglycan from articular and nasal cartilage, carried largely chondroitin sulphate chains, but also some dermatan sulphate, whereas galactosaminoglycan chains derived from aggrecan of nasal cartilage were free of L-iduronate.	Chondroitin Sulfates	115-135	decorin	Bos taurus	0-7
7929840-4	1994	When LDL was preincubated with chondroitin sulfate-free 85-kD M-CSF instead of PG-M-CSF, the elution profile of LDL remained unchanged, indicating specific interaction between PG-M-CSF and LDL.	Chondroitin Sulfates	31-50	colony stimulating factor 1	Homo sapiens	62-67
7929840-5	1994	The level of PG-M-CSF binding in the wells of a plastic microtitration plate precoated with LDL was significant, this binding being completely abolished by pretreatment of PG-M-CSF with chondroitinase AC, which degrades chondroitin sulfate.	Chondroitin Sulfates	220-239	colony stimulating factor 1	Homo sapiens	16-21
7929840-5	1994	The level of PG-M-CSF binding in the wells of a plastic microtitration plate precoated with LDL was significant, this binding being completely abolished by pretreatment of PG-M-CSF with chondroitinase AC, which degrades chondroitin sulfate.	Chondroitin Sulfates	220-239	colony stimulating factor 1	Homo sapiens	175-180
7929840-6	1994	The addition of exogenous chondroitin sulfate or apolipoprotein B inhibited the binding of PG-M-CSF to LDL in a dose-dependent manner, indicating that the interaction between PG-M-CSF and LDL was mediated by the binding of the chondroitin sulfate chain of PG-M-CSF to LDL apolipoprotein B.	Chondroitin Sulfates	26-45	colony stimulating factor 1	Homo sapiens	94-99
7929840-6	1994	The addition of exogenous chondroitin sulfate or apolipoprotein B inhibited the binding of PG-M-CSF to LDL in a dose-dependent manner, indicating that the interaction between PG-M-CSF and LDL was mediated by the binding of the chondroitin sulfate chain of PG-M-CSF to LDL apolipoprotein B.	Chondroitin Sulfates	26-45	colony stimulating factor 1	Homo sapiens	178-183
7532447-5	1994	Thrombomodulin, a chondroitin sulphate-containing proteoglycan, accelerated PCI inhibition of thrombin and APC.	Chondroitin Sulfates	18-38	serpin family A member 5	Homo sapiens	76-79
7532447-5	1994	Thrombomodulin, a chondroitin sulphate-containing proteoglycan, accelerated PCI inhibition of thrombin and APC.	Chondroitin Sulfates	18-38	coagulation factor II, thrombin	Homo sapiens	94-102
7929840-6	1994	The addition of exogenous chondroitin sulfate or apolipoprotein B inhibited the binding of PG-M-CSF to LDL in a dose-dependent manner, indicating that the interaction between PG-M-CSF and LDL was mediated by the binding of the chondroitin sulfate chain of PG-M-CSF to LDL apolipoprotein B.	Chondroitin Sulfates	26-45	colony stimulating factor 1	Homo sapiens	178-183
7929840-6	1994	The addition of exogenous chondroitin sulfate or apolipoprotein B inhibited the binding of PG-M-CSF to LDL in a dose-dependent manner, indicating that the interaction between PG-M-CSF and LDL was mediated by the binding of the chondroitin sulfate chain of PG-M-CSF to LDL apolipoprotein B.	Chondroitin Sulfates	26-45	apolipoprotein B	Homo sapiens	272-288
7929840-6	1994	The addition of exogenous chondroitin sulfate or apolipoprotein B inhibited the binding of PG-M-CSF to LDL in a dose-dependent manner, indicating that the interaction between PG-M-CSF and LDL was mediated by the binding of the chondroitin sulfate chain of PG-M-CSF to LDL apolipoprotein B.	Chondroitin Sulfates	227-246	apolipoprotein B	Homo sapiens	49-65
7929840-6	1994	The addition of exogenous chondroitin sulfate or apolipoprotein B inhibited the binding of PG-M-CSF to LDL in a dose-dependent manner, indicating that the interaction between PG-M-CSF and LDL was mediated by the binding of the chondroitin sulfate chain of PG-M-CSF to LDL apolipoprotein B.	Chondroitin Sulfates	227-246	colony stimulating factor 1	Homo sapiens	94-99
7523632-1	1994	It has been suggested that an inhibitory ECM containing chondroitin-6-sulfate proteoglycan (C-6S-PG) and tenascin (TN), which appears homogeneously in the core of the OB following afferent fiber arrival, helps position ingrowing olfactory axons in the prospective glomerular layer (GL) (Gonzalez and Silver, 1992; Gonzalez et al., 1993).	Chondroitin Sulfates	56-77	tenascin C	Rattus norvegicus	115-117
7899135-7	1994	Accordingly, decorin and biglycan have been identified as major chondroitin sulfate/dermatan sulfate proteoglycans in the extracellular space.	Chondroitin Sulfates	64-83	biglycan	Homo sapiens	25-33
7787799-6	1994	Release of chondroitin 4-sulfate and TXA2 started within 20-30 s after thrombin addition (100 mU/ml).	Chondroitin Sulfates	11-32	coagulation factor II, thrombin	Homo sapiens	71-79
8071334-6	1994	CS GAG modification of APLP2 occurs in a region with little homology to APP.	Chondroitin Sulfates	0-2	amyloid beta (A4) precursor-like protein 2	Mus musculus	23-28
8071334-7	1994	Contained within this heterologous region is a predicted CS modification site, ENEGSGMAEQ (APLP2 residues 610-619); APLP2 polypeptides harboring a serine-to-alanine substitution at position 614 fail to undergo CS GAG modification.	Chondroitin Sulfates	57-59	amyloid beta (A4) precursor-like protein 2	Mus musculus	91-96
8071334-7	1994	Contained within this heterologous region is a predicted CS modification site, ENEGSGMAEQ (APLP2 residues 610-619); APLP2 polypeptides harboring a serine-to-alanine substitution at position 614 fail to undergo CS GAG modification.	Chondroitin Sulfates	57-59	amyloid beta (A4) precursor-like protein 2	Mus musculus	116-121
8071334-7	1994	Contained within this heterologous region is a predicted CS modification site, ENEGSGMAEQ (APLP2 residues 610-619); APLP2 polypeptides harboring a serine-to-alanine substitution at position 614 fail to undergo CS GAG modification.	Chondroitin Sulfates	210-212	amyloid beta (A4) precursor-like protein 2	Mus musculus	116-121
8071334-5	1994	The sensitivity of GAG-modified APLP2 to digestion with chondroitinase AC indicates that chondroitin sulfate (CS) chains are the preponderant GAG on APLP2.	Chondroitin Sulfates	89-108	amyloid beta (A4) precursor-like protein 2	Mus musculus	32-37
8071334-5	1994	The sensitivity of GAG-modified APLP2 to digestion with chondroitinase AC indicates that chondroitin sulfate (CS) chains are the preponderant GAG on APLP2.	Chondroitin Sulfates	89-108	amyloid beta (A4) precursor-like protein 2	Mus musculus	149-154
8071334-5	1994	The sensitivity of GAG-modified APLP2 to digestion with chondroitinase AC indicates that chondroitin sulfate (CS) chains are the preponderant GAG on APLP2.	Chondroitin Sulfates	110-112	amyloid beta (A4) precursor-like protein 2	Mus musculus	32-37
8071334-5	1994	The sensitivity of GAG-modified APLP2 to digestion with chondroitinase AC indicates that chondroitin sulfate (CS) chains are the preponderant GAG on APLP2.	Chondroitin Sulfates	110-112	amyloid beta (A4) precursor-like protein 2	Mus musculus	149-154
7531202-2	1994	We previously showed that many tissues and cells express alternatively spliced multiforms of the large chondroitin sulphate proteoglycan termed PG-M (versican is one of the short transcripts).	Chondroitin Sulfates	103-123	versican	Homo sapiens	150-158
8077056-1	1994	N-terminal sequences of 19 and 11 amino acids obtained from 2 different tryptic fragments of the tumour-specific antigen on the chemically induced rat chondrosarcoma HSN show a 100% homology with the rat chondroitin sulfate proteoglycan NG2.	Chondroitin Sulfates	204-223	chondroitin sulfate proteoglycan 4	Rattus norvegicus	237-240
8001980-1	1994	Deficiency of the lysosomal enzyme, N-acetylgalactosamine 6-sulfatase (GALNS;EC 3.1.6.4), results in the storage of the glycosaminoglycans, keratan sulfate and chondroitin 6-sulfate, which leads to the lysosomal storage disorder Morquio A syndrome.	Chondroitin Sulfates	160-181	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	36-69
8051107-5	1994	Digestion with chondroitinase ABC eliminated this smear and gave rise to a 310/300-kDa doublet band that was not detected without digestion, indicating that almost all of the RPTP beta molecules in the brain contain chondroitin sulfate chains.	Chondroitin Sulfates	216-235	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	15-29
8051107-5	1994	Digestion with chondroitinase ABC eliminated this smear and gave rise to a 310/300-kDa doublet band that was not detected without digestion, indicating that almost all of the RPTP beta molecules in the brain contain chondroitin sulfate chains.	Chondroitin Sulfates	216-235	protein tyrosine phosphatase receptor type Z1	Homo sapiens	175-184
8051107-7	1994	These data establish that RPTP beta is expressed constitutively as a chondroitin sulfate proteoglycan in the brain, and suggest that chondroitin sulfates may be an essential component for the physiological function of RPTP beta in vivo.	Chondroitin Sulfates	69-88	protein tyrosine phosphatase receptor type Z1	Homo sapiens	26-35
8051107-7	1994	These data establish that RPTP beta is expressed constitutively as a chondroitin sulfate proteoglycan in the brain, and suggest that chondroitin sulfates may be an essential component for the physiological function of RPTP beta in vivo.	Chondroitin Sulfates	133-153	protein tyrosine phosphatase receptor type Z1	Homo sapiens	26-35
8051107-7	1994	These data establish that RPTP beta is expressed constitutively as a chondroitin sulfate proteoglycan in the brain, and suggest that chondroitin sulfates may be an essential component for the physiological function of RPTP beta in vivo.	Chondroitin Sulfates	133-153	protein tyrosine phosphatase receptor type Z1	Homo sapiens	218-227
8001980-1	1994	Deficiency of the lysosomal enzyme, N-acetylgalactosamine 6-sulfatase (GALNS;EC 3.1.6.4), results in the storage of the glycosaminoglycans, keratan sulfate and chondroitin 6-sulfate, which leads to the lysosomal storage disorder Morquio A syndrome.	Chondroitin Sulfates	160-181	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	71-76
7528901-9	1994	In an adhesion blocking assay it was found that ligation of CD44 with specific antibody resulted in reduced adhesion to hyaluronan, chondroitin sulphate, fibronectin, laminin, collagen IV and Matrigel.	Chondroitin Sulfates	132-152	CD44 molecule (Indian blood group)	Homo sapiens	60-64
7513709-9	1994	Binding was significantly reduced after treatment of neurocan with chondroitinase, and free chondroitin sulfate inhibited binding of neurocan to Ng-CAM and N-CAM.	Chondroitin Sulfates	92-111	neural cell adhesion molecule 1	Homo sapiens	156-161
8027055-2	1994	Thrombomodulin (TM) binds thrombin through protein-protein contacts and a chondroitin sulfate moiety.	Chondroitin Sulfates	74-93	thrombomodulin	Homo sapiens	0-14
8027055-3	1994	The complex activates the anticoagulant zymogen, protein C. Thrombin and a thrombin mutant with Arg93, Arg97, and Arg101 changed to Ala bind soluble TM lacking the chondroitin sulfate with comparable affinities, but the mutant binds TM containing chondroitin sulfate 45-fold weaker than thrombin.	Chondroitin Sulfates	164-183	coagulation factor II, thrombin	Homo sapiens	60-68
8027055-3	1994	The complex activates the anticoagulant zymogen, protein C. Thrombin and a thrombin mutant with Arg93, Arg97, and Arg101 changed to Ala bind soluble TM lacking the chondroitin sulfate with comparable affinities, but the mutant binds TM containing chondroitin sulfate 45-fold weaker than thrombin.	Chondroitin Sulfates	164-183	coagulation factor II, thrombin	Homo sapiens	75-83
8027055-3	1994	The complex activates the anticoagulant zymogen, protein C. Thrombin and a thrombin mutant with Arg93, Arg97, and Arg101 changed to Ala bind soluble TM lacking the chondroitin sulfate with comparable affinities, but the mutant binds TM containing chondroitin sulfate 45-fold weaker than thrombin.	Chondroitin Sulfates	247-266	coagulation factor II, thrombin	Homo sapiens	60-68
8027055-3	1994	The complex activates the anticoagulant zymogen, protein C. Thrombin and a thrombin mutant with Arg93, Arg97, and Arg101 changed to Ala bind soluble TM lacking the chondroitin sulfate with comparable affinities, but the mutant binds TM containing chondroitin sulfate 45-fold weaker than thrombin.	Chondroitin Sulfates	247-266	coagulation factor II, thrombin	Homo sapiens	75-83
8027055-4	1994	A simple hyperbolic relationship describes the Ca2+ dependence of protein C activation with the thrombin mutant-TM complex whether or not the TM contains chondroitin sulfate.	Chondroitin Sulfates	154-173	coagulation factor II, thrombin	Homo sapiens	96-104
8027055-5	1994	A similar Ca2+ dependence is observed with wild type thrombin only when the TM contains chondroitin sulfate.	Chondroitin Sulfates	88-107	coagulation factor II, thrombin	Homo sapiens	53-61
8040268-9	1994	Inhibition of bFGF activity by PF 4 could be overcome by exogenous heparin or chondroitin-4-sulfate, suggesting that inhibition of mitogenesis is caused by binding of PF 4 to cell-surface glycosaminoglycans.	Chondroitin Sulfates	78-99	fibroblast growth factor 2	Homo sapiens	14-18
7516184-9	1994	Experiments with recombinant TSG-6 and I alpha I purified from human serum showed that the TSG-6/I alpha I complex is rapidly formed even in the apparent absence of other proteins at 37 degrees C, but not at 4 degrees C. The TSG-6/I alpha I complex was cleaved by chondroitin sulfate ABC lyase, suggesting that cross-linking by chondroitin sulfate is required for the stability of the complex.	Chondroitin Sulfates	264-283	TNF alpha induced protein 6	Homo sapiens	91-96
7516184-9	1994	Experiments with recombinant TSG-6 and I alpha I purified from human serum showed that the TSG-6/I alpha I complex is rapidly formed even in the apparent absence of other proteins at 37 degrees C, but not at 4 degrees C. The TSG-6/I alpha I complex was cleaved by chondroitin sulfate ABC lyase, suggesting that cross-linking by chondroitin sulfate is required for the stability of the complex.	Chondroitin Sulfates	264-283	TNF alpha induced protein 6	Homo sapiens	91-96
7516184-9	1994	Experiments with recombinant TSG-6 and I alpha I purified from human serum showed that the TSG-6/I alpha I complex is rapidly formed even in the apparent absence of other proteins at 37 degrees C, but not at 4 degrees C. The TSG-6/I alpha I complex was cleaved by chondroitin sulfate ABC lyase, suggesting that cross-linking by chondroitin sulfate is required for the stability of the complex.	Chondroitin Sulfates	328-347	TNF alpha induced protein 6	Homo sapiens	91-96
7516184-9	1994	Experiments with recombinant TSG-6 and I alpha I purified from human serum showed that the TSG-6/I alpha I complex is rapidly formed even in the apparent absence of other proteins at 37 degrees C, but not at 4 degrees C. The TSG-6/I alpha I complex was cleaved by chondroitin sulfate ABC lyase, suggesting that cross-linking by chondroitin sulfate is required for the stability of the complex.	Chondroitin Sulfates	328-347	TNF alpha induced protein 6	Homo sapiens	91-96
7514167-2	1994	Immunoprecipitation experiments of cells transfected with RPTP beta expression vector and metabolically labeled with [35S]sulfate and [35S]methionine indicate that the transmembrane form of RPTP beta is indeed a chondroitin sulfate proteoglycan.	Chondroitin Sulfates	212-231	protein tyrosine phosphatase receptor type Z1	Homo sapiens	190-199
8074477-4	1994	Rather, both the basal and PMA-induced fibronectin adhesion of MDS cells could be inhibited by heparin and much less efficiently by chondroitin sulphate, suggesting that glycosaminoglycans of proteoglycans may be responsible for the change in adhesive phenotype.	Chondroitin Sulfates	132-152	fibronectin 1	Homo sapiens	39-50
7519189-3	1994	We report here that the monoclonal antibody 473HD, which binds to the surface of early differentiation stages of murine astrocytes and oligodendrocytes, reacts with the chondroitin sulfate/dermatan sulfate hybrid epitope DSD-1 expressed on a central nervous system chondroitin sulfate proteoglycan designated DSD-1-PG.	Chondroitin Sulfates	169-188	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	309-317
7519189-3	1994	We report here that the monoclonal antibody 473HD, which binds to the surface of early differentiation stages of murine astrocytes and oligodendrocytes, reacts with the chondroitin sulfate/dermatan sulfate hybrid epitope DSD-1 expressed on a central nervous system chondroitin sulfate proteoglycan designated DSD-1-PG.	Chondroitin Sulfates	265-284	protein tyrosine phosphatase, receptor type Z, polypeptide 1	Mus musculus	309-317
8193348-3	1994	Enzymatic removal of the chondroitin sulfate chain from PG-M-CSF had no effect on the binding between PG-M-CSF and bFGF.	Chondroitin Sulfates	25-44	colony stimulating factor 1 (macrophage)	Mus musculus	59-64
8182050-8	1994	Heparan sulfate, chondroitin sulfate, and dermatan sulfate, three glycosaminoglycans structurally related to heparin, were &gt; or = 80-fold less effective in binding to RMCP-1 than heparin.	Chondroitin Sulfates	17-36	mast cell protease 1-like 1	Rattus norvegicus	170-176
8163479-1	1994	Thrombomodulin (TM) binds thrombin to form a complex that activates the plasma anticoagulant zymogen protein C. TM is an integral membrane glycoprotein that contains a chondroitin sulfate moiety.	Chondroitin Sulfates	168-187	thrombomodulin	Homo sapiens	0-14
7512960-0	1994	Interactions with tenascin and differential effects on cell adhesion of neurocan and phosphacan, two major chondroitin sulfate proteoglycans of nervous tissue.	Chondroitin Sulfates	107-126	tenascin C	Rattus norvegicus	18-26
8163479-1	1994	Thrombomodulin (TM) binds thrombin to form a complex that activates the plasma anticoagulant zymogen protein C. TM is an integral membrane glycoprotein that contains a chondroitin sulfate moiety.	Chondroitin Sulfates	168-187	thrombomodulin	Homo sapiens	16-18
8163479-1	1994	Thrombomodulin (TM) binds thrombin to form a complex that activates the plasma anticoagulant zymogen protein C. TM is an integral membrane glycoprotein that contains a chondroitin sulfate moiety.	Chondroitin Sulfates	168-187	coagulation factor II, thrombin	Homo sapiens	26-34
8163479-1	1994	Thrombomodulin (TM) binds thrombin to form a complex that activates the plasma anticoagulant zymogen protein C. TM is an integral membrane glycoprotein that contains a chondroitin sulfate moiety.	Chondroitin Sulfates	168-187	thrombomodulin	Homo sapiens	112-114
8163479-2	1994	Interaction with thrombin involves both the protein component of TM, specifically the growth factor-like repeats 4-6 (TM 4-6), and chondroitin sulfate.	Chondroitin Sulfates	131-150	coagulation factor II, thrombin	Homo sapiens	17-25
8163535-0	1994	Core protein structure and sequence determine the site and presence of heparan sulfate and chondroitin sulfate on syndecan-1.	Chondroitin Sulfates	91-110	syndecan 1	Mus musculus	114-124
8163479-3	1994	Removal of chondroitin sulfate decreases the affinity for thrombin approximately 10-fold and shifts the Ca2+ dependence of protein C activation from simple saturation at &gt; or = 500 microM Ca2+ to a distinct optimum at approximately 100 microM Ca2+.	Chondroitin Sulfates	11-30	coagulation factor II, thrombin	Homo sapiens	58-66
8163479-8	1994	At 0.27 mM Ca2+, TM containing chondroitin sulfate binds thrombin (Kd(app) = 0.3 nM) approximately 45 times tighter than meizothrombin des-fragment 1 (Kd(app) = 14 nM).	Chondroitin Sulfates	31-50	thrombomodulin	Homo sapiens	17-19
8163479-8	1994	At 0.27 mM Ca2+, TM containing chondroitin sulfate binds thrombin (Kd(app) = 0.3 nM) approximately 45 times tighter than meizothrombin des-fragment 1 (Kd(app) = 14 nM).	Chondroitin Sulfates	31-50	coagulation factor II, thrombin	Homo sapiens	57-65
8163479-10	1994	These studies suggest that occupancy of anion binding exosite 2 by either chondroitin sulfate or fragment 2 alters thrombin conformation resulting in the altered Ca2+ dependence of protein C activation.	Chondroitin Sulfates	74-93	coagulation factor II, thrombin	Homo sapiens	115-123
8143777-1	1994	Betaglycan (type III transforming growth factor-beta (TGF-beta) receptor) is a cell surface heparan/chondroitin sulfate proteoglycan that binds TGF-beta via its core protein and is abundantly expressed in osteoblastic cells.	Chondroitin Sulfates	100-119	transforming growth factor, beta receptor III	Mus musculus	0-10
8197917-4	1994	Chondroitinase AC treatment eliminated the staining of filaments in the collagenous layers (chondroitin sulfate).	Chondroitin Sulfates	92-111	galactosamine (N-acetyl)-6-sulfate sulfatase	Mus musculus	0-14
8197917-5	1994	Chondroitinase ABC treatment also eliminated the staining of filaments in the collagenous layers (chondroitin sulfate and dermatan sulfate).	Chondroitin Sulfates	98-117	galactosamine (N-acetyl)-6-sulfate sulfatase	Mus musculus	0-14
8143777-1	1994	Betaglycan (type III transforming growth factor-beta (TGF-beta) receptor) is a cell surface heparan/chondroitin sulfate proteoglycan that binds TGF-beta via its core protein and is abundantly expressed in osteoblastic cells.	Chondroitin Sulfates	100-119	transforming growth factor, beta 1	Mus musculus	54-62
7517179-6	1994	gp600 was readily labeled with radioactive sulfate and treatment of gp600 with chondroitinase ABC or AC II generated a lower molecular weight species (18-22 kDa), suggesting that gp600 consists of a small core protein heavily modified with chondroitin sulfate glycosaminoglycan side chains.	Chondroitin Sulfates	240-259	serglycin	Mus musculus	0-5
7517179-7	1994	However, when binding of CD44 was tested in vitro to chondroitinase-sensitive purified glycosaminoglycans, such as chondroitin-4-sulfate, chondroitin-6-sulfate and dermatan sulfate, no binding was demonstrable, suggesting either that a novel type of chondroitinase-sensitive glycosaminoglycan is recognized by CD44 or that association of the glycosaminoglycan with a core protein is required for recognition by CD44.	Chondroitin Sulfates	115-136	CD44 antigen	Mus musculus	25-29
7517179-7	1994	However, when binding of CD44 was tested in vitro to chondroitinase-sensitive purified glycosaminoglycans, such as chondroitin-4-sulfate, chondroitin-6-sulfate and dermatan sulfate, no binding was demonstrable, suggesting either that a novel type of chondroitinase-sensitive glycosaminoglycan is recognized by CD44 or that association of the glycosaminoglycan with a core protein is required for recognition by CD44.	Chondroitin Sulfates	138-159	CD44 antigen	Mus musculus	25-29
8307950-0	1994	Interactions between fibronectin and chondroitin sulfate are modulated by molecular context.	Chondroitin Sulfates	37-56	fibronectin 1	Homo sapiens	21-32
8150035-1	1994	Immunoblot analysis of macrophage colony-stimulating factor (M-CSF) in KM 102 cell-conditioned medium showed the presence of two M-CSF molecular types, one being 85-kd M-CSF, the other a proteoglycan form (PG-M-CSF) carrying a chondroitin sulfate chain of variable length.	Chondroitin Sulfates	227-246	colony stimulating factor 1	Homo sapiens	61-66
8150035-2	1994	When KM 102 cells were stimulated by TNF-alpha, they produced more M-CSF than that produced in unstimulated condition, in which PG-M-CSF had a shorter chondroitin sulfate chain.	Chondroitin Sulfates	151-170	tumor necrosis factor	Homo sapiens	37-46
8150035-2	1994	When KM 102 cells were stimulated by TNF-alpha, they produced more M-CSF than that produced in unstimulated condition, in which PG-M-CSF had a shorter chondroitin sulfate chain.	Chondroitin Sulfates	151-170	colony stimulating factor 1	Homo sapiens	131-136
8150035-3	1994	Although PG-M-CSF has binding affinity for type V collagen, the PG-M-CSF with the shorter chondroitin sulfate chain shows lower affinity.	Chondroitin Sulfates	90-109	colony stimulating factor 1	Homo sapiens	67-72
8150035-4	1994	This spreads in type V collagen-containing agarose gel more easily than does PG-M-CSF with a longer chondroitin sulfate chain.	Chondroitin Sulfates	100-119	colony stimulating factor 1	Homo sapiens	80-85
7511169-7	1994	The relative efficacies of pentosan polysulfate, Congo red, heparin, and chondroitin sulfate in blocking PrP binding to heparin-agarose corresponded with their previously demonstrated potencies in inhibiting protease-resistant PrP accumulation.	Chondroitin Sulfates	73-92	prion protein	Mus musculus	105-108
7511169-7	1994	The relative efficacies of pentosan polysulfate, Congo red, heparin, and chondroitin sulfate in blocking PrP binding to heparin-agarose corresponded with their previously demonstrated potencies in inhibiting protease-resistant PrP accumulation.	Chondroitin Sulfates	73-92	prion protein	Mus musculus	227-230
8016815-7	1994	The enhancement of the activation of plasminogen by t-PA or u-PA was more significant in the presence of HHS-5 than in the presence of chondroitin sulfate C, dextran sulfate or heparin.	Chondroitin Sulfates	135-156	plasminogen activator, tissue type	Homo sapiens	52-56
8016815-7	1994	The enhancement of the activation of plasminogen by t-PA or u-PA was more significant in the presence of HHS-5 than in the presence of chondroitin sulfate C, dextran sulfate or heparin.	Chondroitin Sulfates	135-156	plasminogen activator, urokinase	Homo sapiens	60-64
8307950-8	1994	These results, in combination with the ability of heparin and chondroitin sulfate to compete for binding to DNs, demonstrate that these two glycosaminoglycans interact with similar or overlapping sites in FN.	Chondroitin Sulfates	62-81	fibronectin 1	Homo sapiens	205-207
8307950-10	1994	Reduced binding to chondroitin sulfate was also observed with a larger recombinant FN lacking internal repeats III1-7 indicating that the amino-terminal region acts to limit binding to the carboxyl-terminal domain.	Chondroitin Sulfates	19-38	fibronectin 1	Homo sapiens	83-85
8307950-11	1994	Our results demonstrate that interactions between FN and chondroitin sulfate are modulated by molecular context.	Chondroitin Sulfates	57-76	fibronectin 1	Homo sapiens	50-52
8263027-7	1994	At 2 mM PNP-xyloside, heparan sulfate as well as chondroitin sulfate addition to core proteins was disrupted: the core protein of epican, a heparan sulfate form of CD44 found on keratinocytes, was detected immunologically but lacked heparan sulfate.	Chondroitin Sulfates	49-68	CD44 molecule (Indian blood group)	Homo sapiens	130-136
8076974-8	1994	Addition of glycosaminoglycans such as hyaluronic acid, chondroitin sulphate, and heparin into the medium cause significant increase in the synthesis and secretion of [3H]apoB into the medium indicating a possible secretory control of apoB by local reuptake.	Chondroitin Sulfates	56-76	apolipoprotein B	Rattus norvegicus	171-175
8076974-8	1994	Addition of glycosaminoglycans such as hyaluronic acid, chondroitin sulphate, and heparin into the medium cause significant increase in the synthesis and secretion of [3H]apoB into the medium indicating a possible secretory control of apoB by local reuptake.	Chondroitin Sulfates	56-76	apolipoprotein B	Rattus norvegicus	235-239
7518256-2	1994	The reactivity of the HNK-1 monoclonal antibody to chondroitin sulphates and derived disaccharides was studied using an ELISA inhibition test.	Chondroitin Sulfates	51-72	beta-1,3-glucuronyltransferase 1	Homo sapiens	22-27
8173967-0	1994	Chondroitin sulfate proteoglycan-immunoreactivity of lectin-labeled perineuronal nets around parvalbumin-containing neurons.	Chondroitin Sulfates	0-19	parvalbumin	Rattus norvegicus	93-104
8173967-2	1994	In this study, a triple fluorescence labeling of chondroitin sulfate proteoglycan-immunoreactive (CSPG-ir) and N-acetylgalactosamine (GalNac)-specific plant lectin Wisteria floribunda agglutinin (WFA) binding net components as well as parvalbumin-immunoreactivity (-ir) was performed.	Chondroitin Sulfates	49-68	parvalbumin	Rattus norvegicus	235-246
8187236-6	1994	u-PA-mediated activation of plasminogen is blocked on surfaces including heparin and chondroitin sulfate.	Chondroitin Sulfates	85-104	plasminogen activator, urokinase	Homo sapiens	0-4
8182587-3	1994	Purified proacrosin was allowed to autoactivate at pH 8.0 in the presence of different concentrations of homologous zona glycoproteins, sulfated polymers (fucoidan, chondroitin sulfates A, B and C, dextran sulfate, polyvinylsulfate and heparin) and non-sulfated polymers (dextran, polyvinylphosphate and hyaluronic acid).	Chondroitin Sulfates	165-185	acrosin	Homo sapiens	9-19
8287928-3	1993	In this report, we show that beta-amyloid peptide when presented as an insoluble substrate which mimics its conformation in vivo can induce cortical glial cells in vitro and in vivo to locally deposit chondroitin sulfate containing proteoglycan.	Chondroitin Sulfates	201-220	amyloid beta precursor protein	Homo sapiens	29-49
8261390-6	1993	High doses of granulocyte-macrophage colony-stimulating factor encapsulated in cell-sized gelatin-chondroitin sulfate microspheres were mixed with irradiated tumor cells prior to s.c. injection.	Chondroitin Sulfates	98-117	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	14-62
8172566-5	1993	At the N-terminal end of the C1q A-chain is a leader peptide sequence that anchors the intact C1q molecule firmly in the membrane of macrophages, the C1q molecule can thus be classified as a type II membrane protein, functioning as an additional receptor for molecules known to react with C1q in fluid phase such as the Fc region of IgG, LPS and polyanionic molecules (e.g. chondroitin sulphate, heparin, dextran sulphate etc.).	Chondroitin Sulfates	374-394	complement C1q A chain	Homo sapiens	29-32
8172566-5	1993	At the N-terminal end of the C1q A-chain is a leader peptide sequence that anchors the intact C1q molecule firmly in the membrane of macrophages, the C1q molecule can thus be classified as a type II membrane protein, functioning as an additional receptor for molecules known to react with C1q in fluid phase such as the Fc region of IgG, LPS and polyanionic molecules (e.g. chondroitin sulphate, heparin, dextran sulphate etc.).	Chondroitin Sulfates	374-394	complement C1q A chain	Homo sapiens	94-97
8172566-5	1993	At the N-terminal end of the C1q A-chain is a leader peptide sequence that anchors the intact C1q molecule firmly in the membrane of macrophages, the C1q molecule can thus be classified as a type II membrane protein, functioning as an additional receptor for molecules known to react with C1q in fluid phase such as the Fc region of IgG, LPS and polyanionic molecules (e.g. chondroitin sulphate, heparin, dextran sulphate etc.).	Chondroitin Sulfates	374-394	complement C1q A chain	Homo sapiens	94-97
8172566-5	1993	At the N-terminal end of the C1q A-chain is a leader peptide sequence that anchors the intact C1q molecule firmly in the membrane of macrophages, the C1q molecule can thus be classified as a type II membrane protein, functioning as an additional receptor for molecules known to react with C1q in fluid phase such as the Fc region of IgG, LPS and polyanionic molecules (e.g. chondroitin sulphate, heparin, dextran sulphate etc.).	Chondroitin Sulfates	374-394	complement C1q A chain	Homo sapiens	94-97
8270643-2	1993	We showed previously that a large chondroitin sulfate proteoglycan, PG-M (also known as versican), inhibits cell-substratum adhesion, while basement membrane heparan sulfate proteoglycan (recently named perlecan) does not (Yamagata et al.	Chondroitin Sulfates	34-53	versican	Homo sapiens	88-96
8245966-4	1993	A beta(1-28) associates with heparin, heparan sulfate, dermatan sulfate, and chondroitin sulfate.	Chondroitin Sulfates	77-96	amyloid beta precursor protein	Homo sapiens	0-6
8244345-2	1993	Although no genetic diseases of connective tissue map to this location, the malignant melanoma-associated surface antigen mel-CSPG is located here; mel-CSPG is a chondroitin sulfate proteoglycan.	Chondroitin Sulfates	162-181	chondroitin sulfate proteoglycan 4	Homo sapiens	122-130
8244345-2	1993	Although no genetic diseases of connective tissue map to this location, the malignant melanoma-associated surface antigen mel-CSPG is located here; mel-CSPG is a chondroitin sulfate proteoglycan.	Chondroitin Sulfates	162-181	chondroitin sulfate proteoglycan 4	Homo sapiens	148-156
8216207-2	1993	It has previously been shown that TM is expressed in both a high-M(r) form containing chondroitin sulphate and a low-M(r) form lacking this modification.	Chondroitin Sulfates	86-106	thrombomodulin	Homo sapiens	34-36
8373377-6	1993	Northern-blot analyses of total RNA revealed a pronounced decrease in the steady-state mRNA levels of versican, the large chondroitin sulphate, with levels corresponding to 10-30% of controls.	Chondroitin Sulfates	122-142	versican	Homo sapiens	102-110
7694885-2	1993	The specificity of CD44 receptor-globulin labelling was confirmed using Streptomyces hyaluronidase, anti-chondroitin sulfate antibody, and other receptor globulins.	Chondroitin Sulfates	105-124	CD44 antigen	Mus musculus	19-23
7508696-0	1993	Colocalization of tenascin with versican, a hyaluronate-binding chondroitin sulfate proteoglycan.	Chondroitin Sulfates	64-83	tenascin C	Rattus norvegicus	18-26
7508696-0	1993	Colocalization of tenascin with versican, a hyaluronate-binding chondroitin sulfate proteoglycan.	Chondroitin Sulfates	64-83	versican	Rattus norvegicus	32-40
8266822-2	1993	The addition of TGF-beta 1 resulted in large stimulations of the net CS, but not of the net HA, accumulating in the medium at all cell densities and an abolition of the density-dependent effect.	Chondroitin Sulfates	69-71	transforming growth factor, beta 1	Rattus norvegicus	16-26
8266822-4	1993	Supplementation of the culture media with CS had complex but relatively small effects on the stimulation of the net accumulation of radiolabeled medium CS by TGF-beta 1.	Chondroitin Sulfates	42-44	transforming growth factor, beta 1	Rattus norvegicus	158-168
8266822-4	1993	Supplementation of the culture media with CS had complex but relatively small effects on the stimulation of the net accumulation of radiolabeled medium CS by TGF-beta 1.	Chondroitin Sulfates	152-154	transforming growth factor, beta 1	Rattus norvegicus	158-168
8266822-7	1993	The overall results suggest that, in this cell system, the action of TGF-beta 1 on the synthesis of the major extracellular AGs is characterized by a relatively specific upregulation of CS proteoglycan (PG) synthesis and an uncoupling of the inhibitory effect of high cell density on CS PG synthesis.	Chondroitin Sulfates	186-188	transforming growth factor, beta 1	Rattus norvegicus	69-79
8270643-10	1993	Syndecan-1, a membrane heparan sulfate/chondroitin sulfate proteoglycan, was associated with fibronectin at the cell surface, partly at focal contacts and in association with stress fibers.	Chondroitin Sulfates	39-58	syndecan 1	Homo sapiens	0-10
8270643-10	1993	Syndecan-1, a membrane heparan sulfate/chondroitin sulfate proteoglycan, was associated with fibronectin at the cell surface, partly at focal contacts and in association with stress fibers.	Chondroitin Sulfates	39-58	fibronectin 1	Homo sapiens	93-104
8259541-0	1993	Recombinant human soluble thrombomodulin delivers bounded thrombin to antithrombin III: thrombomodulin associates with free thrombin and is recycled to activate protein c. Recombinant human soluble thrombomodulin (rhs-TM), having no transmembrane domain or chondroitin sulfate, was expressed in Chinese hamster ovary cells.	Chondroitin Sulfates	257-276	thrombomodulin	Homo sapiens	26-40
7504453-6	1993	Within the context of the microvasculature alpha-smooth muscle actin and the HMW-MAA chondroitin sulphate proteoglycan are useful markers for pericytes.	Chondroitin Sulfates	85-105	chondroitin sulfate proteoglycan 4	Homo sapiens	77-84
8344391-5	1993	This transient pattern of expression is very similar to that of type X collagen; however, RIHB induction precedes that of type X collagen by about 24 h. The expression of both RIHB and type X collagen precedes the drop in keratan sulfate:chondroitin sulfate proteoglycan and type II collagen expression and the surge of fibronectin expression.	Chondroitin Sulfates	238-257	midkine (neurite growth-promoting factor 2)	Gallus gallus	90-94
8344391-5	1993	This transient pattern of expression is very similar to that of type X collagen; however, RIHB induction precedes that of type X collagen by about 24 h. The expression of both RIHB and type X collagen precedes the drop in keratan sulfate:chondroitin sulfate proteoglycan and type II collagen expression and the surge of fibronectin expression.	Chondroitin Sulfates	238-257	midkine (neurite growth-promoting factor 2)	Gallus gallus	176-180
8343954-0	1993	The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44.	Chondroitin Sulfates	4-23	CD44 molecule (Indian blood group)	Homo sapiens	117-121
8314802-2	1993	We have isolated cDNA clones encoding the core protein of PG-M, a large chondroitin sulfate proteoglycan that has been shown to be expressed in the prechondrogenic condensation area of the developing chick limb buds (Shinomura T., Jensen, K. L., Yamagata, M., Kimata, K., and Solursh, M. (1990) Anat.	Chondroitin Sulfates	72-91	versican	Gallus gallus	58-62
8214620-0	1993	Chondroitin sulphate proteoglycan and embryonic brain enlargement in the chick.	Chondroitin Sulfates	0-20	versican	Gallus gallus	21-33
8214620-5	1993	An immunocytochemical study to assess the nature of the secreted material has shown that the intraneural matrix contains chondroitin sulphate proteoglycan, which appeared homogeneously distributed throughout the neural cavity.	Chondroitin Sulfates	121-141	versican	Gallus gallus	142-154
8314802-8	1993	On the other hand, the chondroitin sulfate attachment domain at the middle region of the PG-M core protein shows no significant amino acid sequence homology to the corresponding domain of the versican core protein.	Chondroitin Sulfates	23-42	versican	Gallus gallus	89-93
8314802-9	1993	Further, the chondroitin sulfate attachment domain of PG-M core protein is about 100 kDa larger than that of versican core protein.	Chondroitin Sulfates	13-32	versican	Gallus gallus	54-58
8489237-7	1993	The galactosamine-containing glycosaminoglycans, chondroitin sulfate and dermatan sulfate, differ from heparin in that they increase the quantity of soluble elastin in the culture medium and decrease the deposition of insoluble elastin in the extracellular matrix.	Chondroitin Sulfates	49-68	elastin	Rattus norvegicus	157-164
8245755-2	1993	Lysosomal hydrolytic arylsulfatase A and B have been identified as major enzymes initiating and propagating bone loss by degrading chondroitin-4-sulfate.	Chondroitin Sulfates	131-152	arylsulfatase A	Homo sapiens	21-42
7691842-0	1993	Cell surface CD44-related chondroitin sulfate proteoglycan is required for transforming growth factor-beta-stimulated mouse melanoma cell motility and invasive behavior on type I collagen.	Chondroitin Sulfates	26-45	CD44 antigen	Mus musculus	13-17
7691842-5	1993	In our current studies, the role of cell surface CD44-chondroitin sulfate proteoglycan in collagen-mediated mouse melanoma cell migration and invasive behavior is further evaluated using transforming growth factor-beta 1.	Chondroitin Sulfates	54-73	CD44 antigen	Mus musculus	49-53
7691842-7	1993	Transforming growth factor-beta 1 stimulated cell surface CD44-chondroitin sulfate proteoglycan synthesis in mouse melanoma cells, specifically through an upregulation of chondroitin sulfate production, while the expression of CD44-chondroitin sulfate proteoglycan core protein was not affected.	Chondroitin Sulfates	63-82	transforming growth factor, beta 1	Mus musculus	0-33
7691842-7	1993	Transforming growth factor-beta 1 stimulated cell surface CD44-chondroitin sulfate proteoglycan synthesis in mouse melanoma cells, specifically through an upregulation of chondroitin sulfate production, while the expression of CD44-chondroitin sulfate proteoglycan core protein was not affected.	Chondroitin Sulfates	63-82	CD44 antigen	Mus musculus	58-62
7691842-7	1993	Transforming growth factor-beta 1 stimulated cell surface CD44-chondroitin sulfate proteoglycan synthesis in mouse melanoma cells, specifically through an upregulation of chondroitin sulfate production, while the expression of CD44-chondroitin sulfate proteoglycan core protein was not affected.	Chondroitin Sulfates	171-190	transforming growth factor, beta 1	Mus musculus	0-33
7691842-7	1993	Transforming growth factor-beta 1 stimulated cell surface CD44-chondroitin sulfate proteoglycan synthesis in mouse melanoma cells, specifically through an upregulation of chondroitin sulfate production, while the expression of CD44-chondroitin sulfate proteoglycan core protein was not affected.	Chondroitin Sulfates	171-190	CD44 antigen	Mus musculus	58-62
7691842-7	1993	Transforming growth factor-beta 1 stimulated cell surface CD44-chondroitin sulfate proteoglycan synthesis in mouse melanoma cells, specifically through an upregulation of chondroitin sulfate production, while the expression of CD44-chondroitin sulfate proteoglycan core protein was not affected.	Chondroitin Sulfates	171-190	transforming growth factor, beta 1	Mus musculus	0-33
7691842-7	1993	Transforming growth factor-beta 1 stimulated cell surface CD44-chondroitin sulfate proteoglycan synthesis in mouse melanoma cells, specifically through an upregulation of chondroitin sulfate production, while the expression of CD44-chondroitin sulfate proteoglycan core protein was not affected.	Chondroitin Sulfates	171-190	CD44 antigen	Mus musculus	58-62
7691842-8	1993	Furthermore, transforming growth factor-beta 1-mediated enhancement of cell polarity, migration and invasive behavior on type I collagen gels was markedly inhibited in the presence of beta-D-xyloside, an agent that blocks chondroitin sulfate addition to the core protein.	Chondroitin Sulfates	222-241	transforming growth factor, beta 1	Mus musculus	13-46
7691842-9	1993	Collectively, our findings indicate that mouse melanoma cell surface CD44-chondroitin sulfate proteoglycan is required for transforming growth factor-beta 1-enhanced cell motility and invasion, and that CD44-chondroitin sulfate proteoglycan may play a role in forming and/or maintaining a dominant leading lamella, which is required for efficient locomotion.	Chondroitin Sulfates	74-93	CD44 antigen	Mus musculus	69-73
7691842-9	1993	Collectively, our findings indicate that mouse melanoma cell surface CD44-chondroitin sulfate proteoglycan is required for transforming growth factor-beta 1-enhanced cell motility and invasion, and that CD44-chondroitin sulfate proteoglycan may play a role in forming and/or maintaining a dominant leading lamella, which is required for efficient locomotion.	Chondroitin Sulfates	74-93	transforming growth factor, beta 1	Mus musculus	123-156
8389704-4	1993	Testican is the progenitor of the unique heparan/chondroitin-sulfate-bearing peptide present in human seminal plasma, a feature which might confer additional potentialities to this hybrid proteoglycan.	Chondroitin Sulfates	49-68	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1	Homo sapiens	0-8
8508806-7	1993	The capacity of different GAGs to protect bFGF from proteolytic cleavage decreases in the following order: heparin &gt; heparan sulfate &gt; dermatan sulfate = chondroitin sulfates A and C &gt; hyaluronic acid = K5 polysaccharide, indicating that both the degree of sulfation and the backbone structure of GAG modulate its interaction with bFGF.	Chondroitin Sulfates	160-180	fibroblast growth factor 2	Homo sapiens	42-46
8318504-1	1993	Platelet-derived growth factor (PDGF) and transforming growth factor-beta 1 (TGF-beta 1), two growth-regulatory peptides with opposite effects on arterial smooth muscle cell (ASMC) proliferation, were examined for their influence on the synthesis of two small chondroitin sulfate/dermatan sulfate proteoglycans (CS/DS PGs) called biglycan and decorin.	Chondroitin Sulfates	260-279	transforming growth factor beta 1	Homo sapiens	42-75
8318504-1	1993	Platelet-derived growth factor (PDGF) and transforming growth factor-beta 1 (TGF-beta 1), two growth-regulatory peptides with opposite effects on arterial smooth muscle cell (ASMC) proliferation, were examined for their influence on the synthesis of two small chondroitin sulfate/dermatan sulfate proteoglycans (CS/DS PGs) called biglycan and decorin.	Chondroitin Sulfates	260-279	transforming growth factor beta 1	Homo sapiens	77-87
8397923-1	1993	Conditioned medium (CM) of primary cultures of GFAP-positive adherent astrocytes from neonatal rat neocortex contained a chondroitin sulphate/dermatan sulphate proteoglycan (CDSPG) that co-eluted with a heparan sulphate proteoglycan (HSPG) by ion-exchange chromatography.	Chondroitin Sulfates	121-141	syndecan 2	Rattus norvegicus	203-232
8397923-1	1993	Conditioned medium (CM) of primary cultures of GFAP-positive adherent astrocytes from neonatal rat neocortex contained a chondroitin sulphate/dermatan sulphate proteoglycan (CDSPG) that co-eluted with a heparan sulphate proteoglycan (HSPG) by ion-exchange chromatography.	Chondroitin Sulfates	121-141	syndecan 2	Rattus norvegicus	234-238
8371063-4	1993	To determine whether LpL enhances the binding of LDL to arterial chondroitin sulfate (CS)PG and dermatan sulfate (DS)PG, the major extracellular PG of the artery wall, a microtiter plate assay was used to study LpL-PG-LDL interactions.	Chondroitin Sulfates	65-84	lipoprotein lipase	Homo sapiens	21-24
8489237-7	1993	The galactosamine-containing glycosaminoglycans, chondroitin sulfate and dermatan sulfate, differ from heparin in that they increase the quantity of soluble elastin in the culture medium and decrease the deposition of insoluble elastin in the extracellular matrix.	Chondroitin Sulfates	49-68	elastin	Rattus norvegicus	228-235
8500564-2	1993	We report herein studies on the retinas from mice with mucopolysaccharidosis type VII (MPS VII), a storage disorder resulting from virtual absence of beta-glucuronidase, an enzyme that is involved in the lysosomal degradation of chondroitin sulfate and other beta-glucuronide-containing proteoglycans.	Chondroitin Sulfates	229-248	glucuronidase, beta	Mus musculus	150-168
8494047-1	1993	In vitro, chondroitin sulfate (CS) proteoglycans (PGs) bind with high-affinity lipoproteins (LPs) containing apolipoprotein B (apo B), and cultured monocytes incubated with LP-PG complexes transform into foam cells (FCs).	Chondroitin Sulfates	10-29	apolipoprotein B	Oryctolagus cuniculus	109-125
8494047-1	1993	In vitro, chondroitin sulfate (CS) proteoglycans (PGs) bind with high-affinity lipoproteins (LPs) containing apolipoprotein B (apo B), and cultured monocytes incubated with LP-PG complexes transform into foam cells (FCs).	Chondroitin Sulfates	31-33	apolipoprotein B	Oryctolagus cuniculus	109-125
8388364-3	1993	Analysis of mouse T-cell responses to intact or deglycosylated monomers, purified from human articular cartilage, and to synthetic peptides of the chondroitin sulphate (CS) attachment region homologous repeat sequence showed that recognition of T-cell epitopes in the CS1 region was strongly dependent upon the form of antigen used.	Chondroitin Sulfates	147-167	chorionic somatomammotropin hormone 1	Homo sapiens	268-271
7682553-8	1993	Biochemical and mass spectrometric analysis of the peptides containing the cross-link indicate that it is mediated by a chondroitin-4-sulfate chain that originates from a typical O-glycosidic link to Ser10 of bikunin.	Chondroitin Sulfates	120-141	alpha-1-microglobulin/bikunin precursor	Homo sapiens	209-216
7682557-12	1993	In contrast, mMCP-1 and mMCP-2, which are present in granules of mucosal mast cells that contain chondroitin sulfate, lack one of these regions and have a lower charge density in the other.	Chondroitin Sulfates	97-116	mast cell protease 1	Mus musculus	13-19
7682557-12	1993	In contrast, mMCP-1 and mMCP-2, which are present in granules of mucosal mast cells that contain chondroitin sulfate, lack one of these regions and have a lower charge density in the other.	Chondroitin Sulfates	97-116	mast cell protease 2	Mus musculus	24-30
8353596-4	1993	In the juvenile animal, adipocyte stroma continues to support ductal expansion while fibroblasts negatively regulate ductal outgrowth via interactions with the epithelium possibly involving TGF-beta mediated deposition of collagen I and chondroitin sulphate.	Chondroitin Sulfates	237-257	transforming growth factor beta 1	Homo sapiens	190-198
8388364-3	1993	Analysis of mouse T-cell responses to intact or deglycosylated monomers, purified from human articular cartilage, and to synthetic peptides of the chondroitin sulphate (CS) attachment region homologous repeat sequence showed that recognition of T-cell epitopes in the CS1 region was strongly dependent upon the form of antigen used.	Chondroitin Sulfates	169-171	chorionic somatomammotropin hormone 1	Homo sapiens	268-271
8479152-5	1993	RESULTS: The disaccharide products formed from chondroitin sulfate of the 44 cancer patients by action of chondroitinase ABC show a substantial relative increase of non sulfated disaccharide (32.1% +/- 15.2) with a relative decrease of 6-sulfated disaccharide (28.9% +/- 11.5) and 4-sulfated disaccharide (39.0% +/- 13.5) when compared to the chondroitin sulfate of normal subjects (9.1% +/- 2.2, 40.6% +/- 4.5 and 50.2% +/- 4.5, respectively) or from patients with unrelated diseases.	Chondroitin Sulfates	47-66	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	121-124
8479152-5	1993	RESULTS: The disaccharide products formed from chondroitin sulfate of the 44 cancer patients by action of chondroitinase ABC show a substantial relative increase of non sulfated disaccharide (32.1% +/- 15.2) with a relative decrease of 6-sulfated disaccharide (28.9% +/- 11.5) and 4-sulfated disaccharide (39.0% +/- 13.5) when compared to the chondroitin sulfate of normal subjects (9.1% +/- 2.2, 40.6% +/- 4.5 and 50.2% +/- 4.5, respectively) or from patients with unrelated diseases.	Chondroitin Sulfates	343-362	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	121-124
8457216-4	1993	In contrast, biglycan, another small chondroitin sulphate/dermatan sulphate proteoglycan, is found only at the dermal-epidermal border.	Chondroitin Sulfates	37-57	biglycan	Homo sapiens	13-21
8384442-11	1993	The free glycosaminoglycans obtained by alkaline treatment of TM or chondroitin sulphate A also accelerated the inactivation of scu-PA by thrombin, but about 1000-fold higher concentrations than with TM were needed to obtain the same acceleration.	Chondroitin Sulfates	68-88	coagulation factor II, thrombin	Homo sapiens	138-146
8384442-11	1993	The free glycosaminoglycans obtained by alkaline treatment of TM or chondroitin sulphate A also accelerated the inactivation of scu-PA by thrombin, but about 1000-fold higher concentrations than with TM were needed to obtain the same acceleration.	Chondroitin Sulfates	68-88	thrombomodulin	Homo sapiens	200-202
8388351-6	1993	In addition, EGF-like domain 4 is required for thrombomodulin to accelerate the activation of protein C. Some thrombomodulin molecules contain a chondroitin sulfate moiety attached to a Ser/Thr-rich domain adjacent to the cell membrane.	Chondroitin Sulfates	145-164	thrombomodulin	Homo sapiens	47-61
7680011-2	1993	Two chondroitin sulfate-containing complexes have been isolated from fetal bovine serum and shown to contain the serine protease inhibitor bikunin.	Chondroitin Sulfates	4-23	alpha-1-microglobulin/bikunin precursor	Homo sapiens	139-146
7680011-3	1993	A complex of 126 kDa contains bikunin linked by a chondroitin sulfate chain to a protein with homology to the HC2 component of the human inter-alpha-trypsin inhibitor.	Chondroitin Sulfates	50-69	alpha-1-microglobulin/bikunin precursor	Homo sapiens	30-37
7680011-3	1993	A complex of 126 kDa contains bikunin linked by a chondroitin sulfate chain to a protein with homology to the HC2 component of the human inter-alpha-trypsin inhibitor.	Chondroitin Sulfates	50-69	CYCS pseudogene 38	Homo sapiens	110-113
8388351-8	1993	The chondroitin sulfate moiety of thrombomodulin also can affect the rate of thrombin inhibition by antithrombin III, possibly by competing with heparin for the heparin binding site on thrombin.	Chondroitin Sulfates	4-23	thrombomodulin	Homo sapiens	34-48
8388351-6	1993	In addition, EGF-like domain 4 is required for thrombomodulin to accelerate the activation of protein C. Some thrombomodulin molecules contain a chondroitin sulfate moiety attached to a Ser/Thr-rich domain adjacent to the cell membrane.	Chondroitin Sulfates	145-164	thrombomodulin	Homo sapiens	110-124
8388351-8	1993	The chondroitin sulfate moiety of thrombomodulin also can affect the rate of thrombin inhibition by antithrombin III, possibly by competing with heparin for the heparin binding site on thrombin.	Chondroitin Sulfates	4-23	coagulation factor II, thrombin	Homo sapiens	77-85
8431448-4	1993	Inhibition of thrombin by PAI-1 was quantitatively analyzed in the presence of a wide range of concentrations of heparin, heparan sulfate, dermatan sulfate, chondroitin 4-sulfate, chondroitin 6-sulfate, keratan sulfate, and hyaluronic acid by measuring residual amidolytic activity.	Chondroitin Sulfates	180-201	coagulation factor II, thrombin	Homo sapiens	14-22
8388351-8	1993	The chondroitin sulfate moiety of thrombomodulin also can affect the rate of thrombin inhibition by antithrombin III, possibly by competing with heparin for the heparin binding site on thrombin.	Chondroitin Sulfates	4-23	serpin family C member 1	Homo sapiens	100-116
8388351-8	1993	The chondroitin sulfate moiety of thrombomodulin also can affect the rate of thrombin inhibition by antithrombin III, possibly by competing with heparin for the heparin binding site on thrombin.	Chondroitin Sulfates	4-23	coagulation factor II, thrombin	Homo sapiens	104-112
8439543-0	1993	Binding of a synthetic apolipoprotein B-100 peptide and peptide analogues to chondroitin 6-sulfate: effects of the lipid environment.	Chondroitin Sulfates	77-98	apolipoprotein B	Homo sapiens	23-43
8431448-4	1993	Inhibition of thrombin by PAI-1 was quantitatively analyzed in the presence of a wide range of concentrations of heparin, heparan sulfate, dermatan sulfate, chondroitin 4-sulfate, chondroitin 6-sulfate, keratan sulfate, and hyaluronic acid by measuring residual amidolytic activity.	Chondroitin Sulfates	180-201	serpin family E member 1	Homo sapiens	26-31
8381406-0	1993	The chondroitin sulfate moiety of thrombomodulin binds a second molecule of thrombin.	Chondroitin Sulfates	4-23	thrombomodulin	Homo sapiens	34-48
8381406-0	1993	The chondroitin sulfate moiety of thrombomodulin binds a second molecule of thrombin.	Chondroitin Sulfates	4-23	coagulation factor II, thrombin	Homo sapiens	76-84
8381406-5	1993	This suggested that the second thrombin binds to TM via the chondroitin sulfate moiety.	Chondroitin Sulfates	60-79	coagulation factor II, thrombin	Homo sapiens	31-39
8381406-5	1993	This suggested that the second thrombin binds to TM via the chondroitin sulfate moiety.	Chondroitin Sulfates	60-79	thrombomodulin	Homo sapiens	49-51
8381406-6	1993	A direct interaction between thrombin and chondroitin sulfate was demonstrated by showing that chondroitin sulfate, cleaved and purified from TM, caused a saturable increase in ANS emission intensity upon addition to an ANS-FPR-thrombin sample.	Chondroitin Sulfates	42-61	thrombomodulin	Homo sapiens	142-144
8381406-6	1993	A direct interaction between thrombin and chondroitin sulfate was demonstrated by showing that chondroitin sulfate, cleaved and purified from TM, caused a saturable increase in ANS emission intensity upon addition to an ANS-FPR-thrombin sample.	Chondroitin Sulfates	42-61	coagulation factor II, thrombin	Homo sapiens	228-236
8381406-1	1993	The role of the chondroitin sulfate moiety of thrombomodulin (TM) in the binding of thrombin to TM has been examined using fluorescent derivatives of thrombin.	Chondroitin Sulfates	16-35	thrombomodulin	Homo sapiens	46-60
8381406-1	1993	The role of the chondroitin sulfate moiety of thrombomodulin (TM) in the binding of thrombin to TM has been examined using fluorescent derivatives of thrombin.	Chondroitin Sulfates	16-35	thrombomodulin	Homo sapiens	62-64
8381406-1	1993	The role of the chondroitin sulfate moiety of thrombomodulin (TM) in the binding of thrombin to TM has been examined using fluorescent derivatives of thrombin.	Chondroitin Sulfates	16-35	coagulation factor II, thrombin	Homo sapiens	84-92
8381406-1	1993	The role of the chondroitin sulfate moiety of thrombomodulin (TM) in the binding of thrombin to TM has been examined using fluorescent derivatives of thrombin.	Chondroitin Sulfates	16-35	thrombomodulin	Homo sapiens	96-98
8381406-6	1993	A direct interaction between thrombin and chondroitin sulfate was demonstrated by showing that chondroitin sulfate, cleaved and purified from TM, caused a saturable increase in ANS emission intensity upon addition to an ANS-FPR-thrombin sample.	Chondroitin Sulfates	95-114	coagulation factor II, thrombin	Homo sapiens	29-37
8381406-3	1993	When ANS-FPR-thrombin was titrated with TM lacking the chondroitin sulfate moiety (csf-TM), a monotonic and saturable increase in ANS emission intensity was observed that was consistent with the formation of a high affinity 1:1 thrombin-csf-TM complex.	Chondroitin Sulfates	55-74	coagulation factor II, thrombin	Homo sapiens	13-21
8381406-6	1993	A direct interaction between thrombin and chondroitin sulfate was demonstrated by showing that chondroitin sulfate, cleaved and purified from TM, caused a saturable increase in ANS emission intensity upon addition to an ANS-FPR-thrombin sample.	Chondroitin Sulfates	95-114	thrombomodulin	Homo sapiens	142-144
8381406-6	1993	A direct interaction between thrombin and chondroitin sulfate was demonstrated by showing that chondroitin sulfate, cleaved and purified from TM, caused a saturable increase in ANS emission intensity upon addition to an ANS-FPR-thrombin sample.	Chondroitin Sulfates	95-114	coagulation factor II, thrombin	Homo sapiens	228-236
8381406-3	1993	When ANS-FPR-thrombin was titrated with TM lacking the chondroitin sulfate moiety (csf-TM), a monotonic and saturable increase in ANS emission intensity was observed that was consistent with the formation of a high affinity 1:1 thrombin-csf-TM complex.	Chondroitin Sulfates	55-74	thrombomodulin	Homo sapiens	40-42
8381406-8	1993	The minimum Kd for the ANS-FPR-thrombin-chondroitin sulfate complex was approximately 20 nM, consistent with chondroitin sulfate being the lower affinity binding site on TM for thrombin.	Chondroitin Sulfates	40-59	coagulation factor II, thrombin	Homo sapiens	31-39
8381406-3	1993	When ANS-FPR-thrombin was titrated with TM lacking the chondroitin sulfate moiety (csf-TM), a monotonic and saturable increase in ANS emission intensity was observed that was consistent with the formation of a high affinity 1:1 thrombin-csf-TM complex.	Chondroitin Sulfates	55-74	thrombomodulin	Homo sapiens	87-89
8381406-8	1993	The minimum Kd for the ANS-FPR-thrombin-chondroitin sulfate complex was approximately 20 nM, consistent with chondroitin sulfate being the lower affinity binding site on TM for thrombin.	Chondroitin Sulfates	40-59	thrombomodulin	Homo sapiens	170-172
8381406-8	1993	The minimum Kd for the ANS-FPR-thrombin-chondroitin sulfate complex was approximately 20 nM, consistent with chondroitin sulfate being the lower affinity binding site on TM for thrombin.	Chondroitin Sulfates	109-128	coagulation factor II, thrombin	Homo sapiens	31-39
8381406-4	1993	In contrast, titration of ANS-FPR-thrombin with intact TM containing the chondroitin sulfate resulted in a biphasic change in ANS-FPR-thrombin emission intensity that was consistent with each molecule of TM binding at least two molecules of ANS-FPR-thrombin with different affinities.	Chondroitin Sulfates	73-92	coagulation factor II, thrombin	Homo sapiens	34-42
8381406-8	1993	The minimum Kd for the ANS-FPR-thrombin-chondroitin sulfate complex was approximately 20 nM, consistent with chondroitin sulfate being the lower affinity binding site on TM for thrombin.	Chondroitin Sulfates	109-128	thrombomodulin	Homo sapiens	170-172
8381406-4	1993	In contrast, titration of ANS-FPR-thrombin with intact TM containing the chondroitin sulfate resulted in a biphasic change in ANS-FPR-thrombin emission intensity that was consistent with each molecule of TM binding at least two molecules of ANS-FPR-thrombin with different affinities.	Chondroitin Sulfates	73-92	thrombomodulin	Homo sapiens	55-57
8381406-8	1993	The minimum Kd for the ANS-FPR-thrombin-chondroitin sulfate complex was approximately 20 nM, consistent with chondroitin sulfate being the lower affinity binding site on TM for thrombin.	Chondroitin Sulfates	109-128	coagulation factor II, thrombin	Homo sapiens	177-185
8381406-10	1993	Thus, the chondroitin sulfate binds to thrombin somewhere other than anion-binding exosite I, and in doing so, alters the structure and/or environment of the active site more than 15A from the active site serine without detectably changing the conformation near Ser-195.	Chondroitin Sulfates	10-29	coagulation factor II, thrombin	Homo sapiens	39-47
8381406-4	1993	In contrast, titration of ANS-FPR-thrombin with intact TM containing the chondroitin sulfate resulted in a biphasic change in ANS-FPR-thrombin emission intensity that was consistent with each molecule of TM binding at least two molecules of ANS-FPR-thrombin with different affinities.	Chondroitin Sulfates	73-92	coagulation factor II, thrombin	Homo sapiens	134-142
8381406-11	1993	Since excess TM and excess csf-TM increased the ANS emission intensity of ANS-FPR-thrombin to different extents (approximately 15 and approximately 80%, respectively), the chondroitin sulfate also influences the environment of the active site probe even when thrombin is bound to the higher affinity site on TM (GF5-6).	Chondroitin Sulfates	172-191	thrombomodulin	Homo sapiens	13-15
8381406-4	1993	In contrast, titration of ANS-FPR-thrombin with intact TM containing the chondroitin sulfate resulted in a biphasic change in ANS-FPR-thrombin emission intensity that was consistent with each molecule of TM binding at least two molecules of ANS-FPR-thrombin with different affinities.	Chondroitin Sulfates	73-92	thrombomodulin	Homo sapiens	204-206
8381406-11	1993	Since excess TM and excess csf-TM increased the ANS emission intensity of ANS-FPR-thrombin to different extents (approximately 15 and approximately 80%, respectively), the chondroitin sulfate also influences the environment of the active site probe even when thrombin is bound to the higher affinity site on TM (GF5-6).	Chondroitin Sulfates	172-191	thrombomodulin	Homo sapiens	31-33
8381406-4	1993	In contrast, titration of ANS-FPR-thrombin with intact TM containing the chondroitin sulfate resulted in a biphasic change in ANS-FPR-thrombin emission intensity that was consistent with each molecule of TM binding at least two molecules of ANS-FPR-thrombin with different affinities.	Chondroitin Sulfates	73-92	coagulation factor II, thrombin	Homo sapiens	134-142
8381406-11	1993	Since excess TM and excess csf-TM increased the ANS emission intensity of ANS-FPR-thrombin to different extents (approximately 15 and approximately 80%, respectively), the chondroitin sulfate also influences the environment of the active site probe even when thrombin is bound to the higher affinity site on TM (GF5-6).	Chondroitin Sulfates	172-191	coagulation factor II, thrombin	Homo sapiens	82-90
8381406-11	1993	Since excess TM and excess csf-TM increased the ANS emission intensity of ANS-FPR-thrombin to different extents (approximately 15 and approximately 80%, respectively), the chondroitin sulfate also influences the environment of the active site probe even when thrombin is bound to the higher affinity site on TM (GF5-6).	Chondroitin Sulfates	172-191	coagulation factor II, thrombin	Homo sapiens	259-267
8381406-11	1993	Since excess TM and excess csf-TM increased the ANS emission intensity of ANS-FPR-thrombin to different extents (approximately 15 and approximately 80%, respectively), the chondroitin sulfate also influences the environment of the active site probe even when thrombin is bound to the higher affinity site on TM (GF5-6).	Chondroitin Sulfates	172-191	thrombomodulin	Homo sapiens	31-33
8419396-6	1993	Chondroitin sulfate A prevented neither the binding of bFGF to both sites of the cells nor bFGF-induced cell proliferation.	Chondroitin Sulfates	0-21	fibroblast growth factor 2	Homo sapiens	55-59
8429233-4	1993	Migration studies of CD44(+) cell lines on hyaluronic acid- and chondroitin-6-sulfate-coated substrates, using time-lapse video-microscopy, showed a dramatic dose-dependent increase in migration rate on hyaluronate but not on chondroitin-6-sulfate.	Chondroitin Sulfates	64-85	CD44 molecule (Indian blood group)	Homo sapiens	21-25
8429233-4	1993	Migration studies of CD44(+) cell lines on hyaluronic acid- and chondroitin-6-sulfate-coated substrates, using time-lapse video-microscopy, showed a dramatic dose-dependent increase in migration rate on hyaluronate but not on chondroitin-6-sulfate.	Chondroitin Sulfates	226-247	CD44 molecule (Indian blood group)	Homo sapiens	21-25
8419396-6	1993	Chondroitin sulfate A prevented neither the binding of bFGF to both sites of the cells nor bFGF-induced cell proliferation.	Chondroitin Sulfates	0-21	fibroblast growth factor 2	Homo sapiens	91-95
1478664-1	1992	Versican is a major chondroitin sulfate proteoglycan of vascularized connective tissues whose eponym reflects its functional versatility in macromolecular affinity and interactions.	Chondroitin Sulfates	20-39	versican	Homo sapiens	0-8
1427856-1	1992	Arylsulfatase B (ARSB) is the lysosomal enzyme that catalyzes the hydrolysis of 4-sulfate groups from N-acetylgalactosamine 4-sulfate moieties on the glycosaminoglycans, dermatan sulfate and chondroitin sulfate A.	Chondroitin Sulfates	191-212	arylsulfatase B	Homo sapiens	0-15
1465181-3	1992	Heparan sulphate, heparinase lyase type I and to a lesser degree, heparin and chondroitin sulphate were effective in solubilizing a large part of the cholinesterase activity.	Chondroitin Sulfates	78-98	butyrylcholinesterase	Homo sapiens	150-164
1333980-0	1992	Vascular smooth muscle cell detachment from elastin and migration through elastic laminae is promoted by chondroitin sulfate-induced "shedding" of the 67-kDa cell surface elastin binding protein.	Chondroitin Sulfates	105-124	elastin	Ovis aries	44-51
1333980-0	1992	Vascular smooth muscle cell detachment from elastin and migration through elastic laminae is promoted by chondroitin sulfate-induced "shedding" of the 67-kDa cell surface elastin binding protein.	Chondroitin Sulfates	105-124	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Ovis aries	171-194
1333980-2	1992	It is also seen in cultured aortic (Ao) smooth muscle cells (SMC) following the release of the EBP by glycosaminoglycans rich in N-acetylgalactosamine, such as chondroitin sulfate (CS).	Chondroitin Sulfates	160-179	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Ovis aries	95-98
1333980-2	1992	It is also seen in cultured aortic (Ao) smooth muscle cells (SMC) following the release of the EBP by glycosaminoglycans rich in N-acetylgalactosamine, such as chondroitin sulfate (CS).	Chondroitin Sulfates	181-183	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Ovis aries	95-98
1333980-6	1992	Addition of CS but not heparan sulfate (a glycosaminoglycan which does not induce EBP shedding) decreased Ao SMC attachment to elastin, as did preincubation with VGVAPG elastin-derived peptides which saturate the EBP.	Chondroitin Sulfates	12-14	elastin	Ovis aries	127-134
1333980-6	1992	Addition of CS but not heparan sulfate (a glycosaminoglycan which does not induce EBP shedding) decreased Ao SMC attachment to elastin, as did preincubation with VGVAPG elastin-derived peptides which saturate the EBP.	Chondroitin Sulfates	12-14	elastin	Ovis aries	169-176
1333980-6	1992	Addition of CS but not heparan sulfate (a glycosaminoglycan which does not induce EBP shedding) decreased Ao SMC attachment to elastin, as did preincubation with VGVAPG elastin-derived peptides which saturate the EBP.	Chondroitin Sulfates	12-14	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Ovis aries	213-216
1333980-7	1992	The immunolocalization of cell surface EBP suggested that cells can quickly replace EBP released from their surfaces by CS treatment.	Chondroitin Sulfates	120-122	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Ovis aries	39-42
1333980-7	1992	The immunolocalization of cell surface EBP suggested that cells can quickly replace EBP released from their surfaces by CS treatment.	Chondroitin Sulfates	120-122	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Ovis aries	84-87
1333980-8	1992	The magnitude of CS-induced impaired attachment of SMC to elastin was dose dependent and could be further increased by the administration of cyclohexamide and sodium azide.	Chondroitin Sulfates	17-19	elastin	Ovis aries	58-65
1333980-10	1992	This suggests that a process of new synthesis and intracellular transport of the EBP was necessary to replace the EBP molecules released from the cell surface by CS treatment.	Chondroitin Sulfates	162-164	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Ovis aries	81-84
1333980-10	1992	This suggests that a process of new synthesis and intracellular transport of the EBP was necessary to replace the EBP molecules released from the cell surface by CS treatment.	Chondroitin Sulfates	162-164	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Ovis aries	114-117
1333980-12	1992	Addition of CS, which induced shedding of EBP, resulted in Ao SMC migration associated with increased synthesis of fibronectin.	Chondroitin Sulfates	12-14	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Ovis aries	42-45
1333980-13	1992	We postulate that CS-induced release of EBP from SMC surfaces causes cell detachment from elastin and an increase in fibronectin synthesis, processes which may be critical in promoting SMC migration associated with intimal thickening developmentally in the DA and perhaps also in vascular disease.	Chondroitin Sulfates	18-20	3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Ovis aries	40-43
1333980-13	1992	We postulate that CS-induced release of EBP from SMC surfaces causes cell detachment from elastin and an increase in fibronectin synthesis, processes which may be critical in promoting SMC migration associated with intimal thickening developmentally in the DA and perhaps also in vascular disease.	Chondroitin Sulfates	18-20	elastin	Ovis aries	90-97
1427856-1	1992	Arylsulfatase B (ARSB) is the lysosomal enzyme that catalyzes the hydrolysis of 4-sulfate groups from N-acetylgalactosamine 4-sulfate moieties on the glycosaminoglycans, dermatan sulfate and chondroitin sulfate A.	Chondroitin Sulfates	191-212	arylsulfatase B	Homo sapiens	17-21
1612781-6	1992	Nerve-growth-factor (NGF)-induced differentiation in a variant HTLA 230 cell line was inhibited when cells were grown on an ECM with a low ratio of chondroitin sulfate/HA.	Chondroitin Sulfates	148-167	nerve growth factor	Homo sapiens	0-19
1522122-7	1992	The structural composition of the galactosaminoglycan chain does not appear to be functionally significant since both chondroitin sulfate and various dermatan sulfate proteoglycans of this family inhibit cell attachment to the fibronectin fragment.	Chondroitin Sulfates	118-137	fibronectin 1	Rattus norvegicus	227-238
1512223-8	1992	Addition of exogenous chondroitin sulfate inhibited the binding of PG-M-CSF to type V collagen in a dose-dependent manner.	Chondroitin Sulfates	22-41	colony stimulating factor 1 (macrophage)	Mus musculus	67-75
1512223-9	1992	These data indicated that the interaction between PG-M-CSF and type V collagen was mediated by the chondroitin sulfate chain of PG-M-CSF.	Chondroitin Sulfates	99-118	colony stimulating factor 1 (macrophage)	Mus musculus	50-58
1512223-9	1992	These data indicated that the interaction between PG-M-CSF and type V collagen was mediated by the chondroitin sulfate chain of PG-M-CSF.	Chondroitin Sulfates	99-118	colony stimulating factor 1 (macrophage)	Mus musculus	128-136
1612781-6	1992	Nerve-growth-factor (NGF)-induced differentiation in a variant HTLA 230 cell line was inhibited when cells were grown on an ECM with a low ratio of chondroitin sulfate/HA.	Chondroitin Sulfates	148-167	nerve growth factor	Homo sapiens	21-24
1559756-7	1992	The label for IRBP was found in the region containing chondroitin 6-sulfate and the IPM surrounding the rod photoreceptors.	Chondroitin Sulfates	54-75	retinol binding protein 3	Homo sapiens	14-18
1378017-6	1992	The binding of GMP-140 to primed T cells is not influenced by preactivation with phorbol 12-myristate 13-acetate, is almost completely abolished by pretreatment of T cells with neuraminidase or trypsin, and is also strongly inhibited by EDTA, the soluble sulfated glycans dextran sulfate, fucoidan, and heparin, but not by chondroitin sulfates.	Chondroitin Sulfates	323-343	selectin P	Homo sapiens	15-22
1378017-6	1992	The binding of GMP-140 to primed T cells is not influenced by preactivation with phorbol 12-myristate 13-acetate, is almost completely abolished by pretreatment of T cells with neuraminidase or trypsin, and is also strongly inhibited by EDTA, the soluble sulfated glycans dextran sulfate, fucoidan, and heparin, but not by chondroitin sulfates.	Chondroitin Sulfates	323-343	neuraminidase 1	Homo sapiens	177-190
1586149-5	1992	In serum, bikunin occurs mainly as a subunit of the pre-alpha-inhibitor and the inter-alpha-inhibitor; in these proteins it is covalently linked to the other polypeptides through its chondroitin sulfate chain.	Chondroitin Sulfates	183-202	alpha-1-microglobulin/bikunin precursor	Homo sapiens	10-17
1586149-11	1992	These results demonstrate that the completion of the chondroitin sulfate chain and its coupling to other polypeptide chains occur before the cleavage of the alpha 1-microglobulin/bikunin precursor.	Chondroitin Sulfates	53-72	alpha-1-microglobulin/bikunin precursor	Rattus norvegicus	157-186
1433977-5	1992	This type of M-CSF has a molecular weight of greater than 200 kDa and consists of a 43 kDa subunit and a 150-200 kDa subunit, the latter of which contains chondroitin sulfate glycosaminoglycan.	Chondroitin Sulfates	155-174	colony stimulating factor 1	Homo sapiens	13-18
1629241-0	1992	Coordinate role for cell surface chondroitin sulfate proteoglycan and alpha 4 beta 1 integrin in mediating melanoma cell adhesion to fibronectin.	Chondroitin Sulfates	33-52	fibronectin 1	Homo sapiens	133-144
1317850-4	1992	Therefore, all three thrombomodulin fragments, each of which lacked the chondroitin sulfate moiety, competed with Hirugen for binding to thrombin.	Chondroitin Sulfates	72-91	thrombomodulin	Homo sapiens	21-35
1317850-10	1992	The contact sites on thrombin for the GF4 domain and the chondroitin sulfate moiety of thrombomodulin are still unknown.	Chondroitin Sulfates	57-76	coagulation factor II, thrombin	Homo sapiens	21-29
1317850-10	1992	The contact sites on thrombin for the GF4 domain and the chondroitin sulfate moiety of thrombomodulin are still unknown.	Chondroitin Sulfates	57-76	thrombomodulin	Homo sapiens	87-101
1377218-2	1992	Although the C1q-R itself appears to bind preferentially to C1q, the region of the ligand to which C1q-R binds is the primary binding site for several other molecules, including fibronectin, laminin, and C1q inhibitor (chondroitin 4-sulfate proteoglycan) as well as the complement C1r2C1s2 tetramer.	Chondroitin Sulfates	219-240	CD93 molecule	Homo sapiens	13-18
1377218-2	1992	Although the C1q-R itself appears to bind preferentially to C1q, the region of the ligand to which C1q-R binds is the primary binding site for several other molecules, including fibronectin, laminin, and C1q inhibitor (chondroitin 4-sulfate proteoglycan) as well as the complement C1r2C1s2 tetramer.	Chondroitin Sulfates	219-240	CD93 molecule	Homo sapiens	99-104
1314561-9	1992	The chondroitin sulphate-attachment site was assigned to Ser-492 as this residue is conserved in mouse and bovine thrombomodulin and lies within a sequence Ser-Gly-Ser-492-Gly-Glu-Pro, which has strong similarity to chondroitin sulphate attachment sites in other proteoglycans.	Chondroitin Sulfates	4-24	thrombomodulin	Bos taurus	114-128
1314561-12	1992	The present studies demonstrate, however, that the presence of chondroitin sulphate in human thrombomodulin has profound effects on all of the anticoagulant properties of this important anticoagulant thrombin receptor.	Chondroitin Sulfates	63-83	thrombomodulin	Homo sapiens	93-107
1313430-8	1992	Deletion of the Ser/Thr-rich domain dramatically decreased both thrombin binding affinity and cofactor activity and also prevented the formation of a high molecular weight thrombomodulin species containing chondroitin sulfate.	Chondroitin Sulfates	206-225	thrombomodulin	Homo sapiens	172-186
1730778-3	1992	A subset of lymphocyte CD44 molecules is modified by covalent linkage to chondroitin sulfate (Jalkanen, S., M. Jalkanen, R. Bargatze, M. Tammi, and E. C. Butcher.	Chondroitin Sulfates	73-92	CD44 molecule (Indian blood group)	Homo sapiens	23-27
1575488-5	1992	The absence of chondro-6-sulfatase activity in extracts from 46-1 allowed us to detect a previously unknown activity of another enzyme in the CS breakdown pathway, beta-glucuronidase.	Chondroitin Sulfates	142-144	glucuronidase, beta	Mus musculus	164-182
1575488-6	1992	In addition to hydrolyzing its normal substrate (an unsulfated disaccharide), beta-glucuronidase also hydrolyzed the 6-sulfated disaccharide subunit of CS.	Chondroitin Sulfates	152-154	glucuronidase, beta	Mus musculus	78-96
1733926-8	1992	These results are consistent with intracellular proteolytic cleavage of the 80-kDa chondroitin sulfate containing subunits from the membrane spanning CSF-1 precursor at a point carboxyl-terminal to the single consensus sequence for glycosaminoglycan addition and cleavage of the 50-kDa glycoprotein subunit at a position aminoterminal to this site.	Chondroitin Sulfates	83-102	colony stimulating factor 1 (macrophage)	Mus musculus	150-155
1730778-9	1992	Binding to fibronectin was studied more closely, and it was found to be mediated through the chondroitin sulfate-containing form of the molecule.	Chondroitin Sulfates	93-112	fibronectin 1	Homo sapiens	11-22
1730778-10	1992	The binding site on fibronectin was the COOH-terminal heparin binding domain, because (a) the COOH-terminal heparin-binding fragment of fibronectin-bound isolated CD44 antigen; (b) chondroitin sulfate inhibited this binding; and (c) finally, the ectodomain of another cell surface proteoglycan, syndecan, which is known to bind the COOH-terminal heparin binding domain of fibronectin (Saunders, S., and M. Bernfield.	Chondroitin Sulfates	181-200	fibronectin 1	Homo sapiens	20-31
1730778-10	1992	The binding site on fibronectin was the COOH-terminal heparin binding domain, because (a) the COOH-terminal heparin-binding fragment of fibronectin-bound isolated CD44 antigen; (b) chondroitin sulfate inhibited this binding; and (c) finally, the ectodomain of another cell surface proteoglycan, syndecan, which is known to bind the COOH-terminal heparin binding domain of fibronectin (Saunders, S., and M. Bernfield.	Chondroitin Sulfates	181-200	fibronectin 1	Homo sapiens	136-147
1730778-10	1992	The binding site on fibronectin was the COOH-terminal heparin binding domain, because (a) the COOH-terminal heparin-binding fragment of fibronectin-bound isolated CD44 antigen; (b) chondroitin sulfate inhibited this binding; and (c) finally, the ectodomain of another cell surface proteoglycan, syndecan, which is known to bind the COOH-terminal heparin binding domain of fibronectin (Saunders, S., and M. Bernfield.	Chondroitin Sulfates	181-200	CD44 molecule (Indian blood group)	Homo sapiens	163-167
1730778-10	1992	The binding site on fibronectin was the COOH-terminal heparin binding domain, because (a) the COOH-terminal heparin-binding fragment of fibronectin-bound isolated CD44 antigen; (b) chondroitin sulfate inhibited this binding; and (c) finally, the ectodomain of another cell surface proteoglycan, syndecan, which is known to bind the COOH-terminal heparin binding domain of fibronectin (Saunders, S., and M. Bernfield.	Chondroitin Sulfates	181-200	syndecan 1	Homo sapiens	295-303
1730778-10	1992	The binding site on fibronectin was the COOH-terminal heparin binding domain, because (a) the COOH-terminal heparin-binding fragment of fibronectin-bound isolated CD44 antigen; (b) chondroitin sulfate inhibited this binding; and (c) finally, the ectodomain of another cell surface proteoglycan, syndecan, which is known to bind the COOH-terminal heparin binding domain of fibronectin (Saunders, S., and M. Bernfield.	Chondroitin Sulfates	181-200	fibronectin 1	Homo sapiens	136-147
1730778-16	1992	These findings suggest that recirculating lymphocytes use the CD44 class of molecules not only for binding to HEV at the site of lymphocyte entry to lymphoid organs as reported earlier but also within the lymphatic tissue where CD44, especially the subset modified by chondroitin sulfate, is used for interaction with extracellular matrix molecules such as fibronectin.	Chondroitin Sulfates	268-287	CD44 molecule (Indian blood group)	Homo sapiens	62-66
1730766-0	1992	A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion.	Chondroitin Sulfates	15-34	CD44 antigen	Mus musculus	76-80
1730766-5	1992	Melanoma cell motility on type I collagen could also be inhibited by removing cell surface chondroitin sulfate with chondroitinase.	Chondroitin Sulfates	91-110	galactosamine (N-acetyl)-6-sulfate sulfatase	Mus musculus	116-130
1730766-10	1992	Collectively, our data suggests that interactions between a cell surface CD44-related CSPG and type I collagen in the ECM may play an important role in mouse melanoma cell motility and invasion, and that the chondroitin sulfate portion of the proteoglycan seems to be a critical component in mediating this effect.	Chondroitin Sulfates	208-227	CD44 antigen	Mus musculus	73-77
1795411-13	1991	(3) A high concentration of EGF could "antagonize" the CDS induced growth retarding effects of endothelial cells.	Chondroitin Sulfates	55-58	epidermal growth factor	Sus scrofa	28-31
1802719-2	1991	However, the loss of chondroitin sulfate proteoglycan (CSPG) and type II collagen gene expression (markers of the differentiated chondrocyte) does not occur for all polygonal or fibroblast-like cells at the same stage of culture.	Chondroitin Sulfates	21-40	versican	Gallus gallus	41-53
1683874-6	1991	Immunofluorescent techniques showed that binding of exogenous TGase to ECM was prevented by prior mixing with fibronectin or collagen, but not with several other ECM components, including laminin, elastin, chondroitin sulfate, heparan sulfate, and hyaluronic acid.	Chondroitin Sulfates	206-225	transglutaminase 1	Homo sapiens	62-67
1661296-6	1991	We hypothesized that CS or dermatan sulfate (DS), both N-acetylgalactosamine glycosaminoglycans (GAGs), may be similar to free galactosugars in causing release of the 67-kD elastin binding protein (EBP) from the smooth muscle cell surfaces and impaired elastin fiber assembly.	Chondroitin Sulfates	21-23	EBP, cholestenol delta-isomerase	Rattus norvegicus	198-201
1661296-8	1991	Also, reduced EBP was observed in fetal lamb and neonatal rat Ao smooth muscle cells incubated with N-acetylgalactosamine GAGs, CS, and DS, but not with N-acetylglucosamine containing GAGs, heparan sulfate (HS), or hyaluronan.	Chondroitin Sulfates	128-130	EBP, cholestenol delta-isomerase	Rattus norvegicus	14-17
1661296-11	1991	The EBP extracted from smooth muscle cell membranes binds to an elastin affinity gel and can be eluted from it with CS but not with HS.	Chondroitin Sulfates	116-118	EBP, cholestenol delta-isomerase	Rattus norvegicus	4-7
1720121-7	1991	Chondroitin-6-sulfate effectively neutralized tenascin activity, whereas dermatan sulfate and chondroitin-4-sulfate were less active and heparan sulfate and heparin were essentially inactive.	Chondroitin Sulfates	0-21	tenascin C	Homo sapiens	46-54
1787444-4	1991	It was capable of accelerating the conversion of proacrosin to acrosin and this activity was abolished by enzymatic removal of chondroitin sulphate, the predominant glycosaminoglycan of this proteoglycan fraction.	Chondroitin Sulfates	127-147	acrosin	Homo sapiens	49-59
1787444-4	1991	It was capable of accelerating the conversion of proacrosin to acrosin and this activity was abolished by enzymatic removal of chondroitin sulphate, the predominant glycosaminoglycan of this proteoglycan fraction.	Chondroitin Sulfates	127-147	acrosin	Homo sapiens	52-59
1787444-6	1991	The results suggest that chondroitin sulphate is the active component of the high-Mr proacrosin activator of the human cumulus-oophorus.	Chondroitin Sulfates	25-45	acrosin	Homo sapiens	85-95