PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2506547-1	1989	Several mutants of the human cell line ME-180 resistant to the cytotoxic effect of interferon gamma (IFN-gamma) were isolated after mutagenesis with nitrosoguanidine.	Nitrosoguanidines	149-165	interferon gamma	Homo sapiens	83-110
3039012-0	1987	In vivo Streptococcus pyogenes C5a peptidase activity: analysis using transposon- and nitrosoguanidine-induced mutants.	Nitrosoguanidines	86-102	complement C5a receptor 1	Homo sapiens	31-34
2832014-2	1988	Nitrosoguanidine induced mutations of transfer regulation system and incompatibility of this plasmid related with alteration in the situation of recognition sites for restrictases EcoR1 and Sal1 in map positions 42.2-4.3 and 12.9-17.9 MD.	Nitrosoguanidines	0-16	spalt like transcription factor 1	Homo sapiens	190-194
6135148-2	1983	Recent studies have suggested that cyclic GMP accumulation in platelets mediates the antiaggregatory effects of certain nitrogen oxide-containing agents such as sodium nitroprusside, nitric oxide, nitrosoguanidines, and related agents.	Nitrosoguanidines	197-214	5'-nucleotidase, cytosolic II	Homo sapiens	42-45
3115798-1	1987	A selection strategy to obtain cells deficient in poly(ADP-ribose) polymerase was developed based on the fact that treatment with high levels of N-methyl-N"-nitro-N-nitrosoguanidine results in sufficient activation of poly(ADP-ribose) polymerase to cause NAD and ATP depletion leading to cessation of all energy-dependent processes and rapid cell death.	Nitrosoguanidines	165-181	poly(ADP-ribose) polymerase 1	Homo sapiens	50-77
3115798-1	1987	A selection strategy to obtain cells deficient in poly(ADP-ribose) polymerase was developed based on the fact that treatment with high levels of N-methyl-N"-nitro-N-nitrosoguanidine results in sufficient activation of poly(ADP-ribose) polymerase to cause NAD and ATP depletion leading to cessation of all energy-dependent processes and rapid cell death.	Nitrosoguanidines	165-181	poly(ADP-ribose) polymerase 1	Homo sapiens	218-245
7002720-1	1980	Reversion from the suppressed to nonsuppressed phenotype in strains of geno;type SUQ5 [psi+] ade2-1 his5-2 lys1-1 can1-100 ura3-1 has been induced by treatment with ethyl methanesulphonate, nitrosoguanidine or UV (254 nm) light.	Nitrosoguanidines	190-206	arginine permease CAN1	Saccharomyces cerevisiae S288C	114-118
7035922-0	1981	The effects of mutations in the polA and recA genes on mutagenesis by nitrosoguanidine in Salmonella typhimurium.	Nitrosoguanidines	70-86	DNA polymerase I	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	32-36
7035922-0	1981	The effects of mutations in the polA and recA genes on mutagenesis by nitrosoguanidine in Salmonella typhimurium.	Nitrosoguanidines	70-86	recombinase RecA	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	41-45
7035922-1	1981	Results of semi-quantitative plate tests indicated that polA and recA mutants of Salmonella typhimurium strain LT2 trpB1 might be significantly less mutable by nitrosoguanidine (MNNG) than were their repair-proficient parents strains.	Nitrosoguanidines	160-176	DNA polymerase I	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	56-60
7035922-1	1981	Results of semi-quantitative plate tests indicated that polA and recA mutants of Salmonella typhimurium strain LT2 trpB1 might be significantly less mutable by nitrosoguanidine (MNNG) than were their repair-proficient parents strains.	Nitrosoguanidines	160-176	recombinase RecA	Salmonella enterica subsp. enterica serovar Typhimurium str. LT2	65-69
7014359-4	1980	The presence of Ib-P9 reduced the ability of cells carrying the colicinogenic factor E1 to induce colicin E1 synthesis under the action of DNA-damaged agents (UV, nitrosoguanidine, mitomycin C), while plasmid V-K30 enhanced the induction of colicin E1 synthesis.	Nitrosoguanidines	163-179	cellular communication network factor 3	Homo sapiens	16-21
479110-6	1979	The close genetic linkage of htx to rif (as high as 98%) resulted in a high comutation frequency of these two loci by nitrosoguanidine mutagenesis.	Nitrosoguanidines	118-134	Zic family member 3	Homo sapiens	29-32
1028169-3	1976	A cell line, THO2, was isolated from Balb/3T3 clone A31 after sequential nitrosoguanidine treatments and selection for resistance to 6-thioguanine and ouabain.	Nitrosoguanidines	73-89	THO complex 2	Mus musculus	13-17
12172962-1	2002	A novel mutant isolate of Saccharomyces cerevisiae, sensitive to photoactivated mono- and bi-functional psoralens, to UV at 254 nm (UVC), and to nitrosoguanidine, was found to complement the photoactivated psoralen-sensitivity phenotype conferred by the pso1- pso7 mutations and was therefore named pso8-1.	Nitrosoguanidines	145-161	DNA-directed DNA polymerase	Saccharomyces cerevisiae S288C	254-258
23462233-7	2013	When mice were treated ip with the major neonicotinoid imidacloprid (IMI), metabolism by CYP oxidation reactions was not appreciably affected, whereas the AOX-generated nitrosoguanidine metabolite was decreased by 30% with tungsten and 56% with hydralazine and 86% in the AOX-deficient mice.	Nitrosoguanidines	169-185	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	155-158
18001059-3	2007	Rabbit liver AOX is capable of reducing IMI to both its nitrosoguanidine (IMI-NO) and aminoguanidine (IMI-NH2) derivatives; however, when IMI-NO is used as a substrate, less than stoichiometric amounts of IMI-NH2 are detected while IMI-NO is completely consumed.	Nitrosoguanidines	56-72	acyl-CoA oxidase 1	Homo sapiens	13-16
16411654-2	2006	Aldehyde oxidase (AOX) was recently identified as the imidacloprid nitroreductase of mammalian liver, producing both nitrosoguanidine and aminoguanidine metabolites.	Nitrosoguanidines	117-133	aldehyde oxidase 1	Homo sapiens	0-16
16411654-2	2006	Aldehyde oxidase (AOX) was recently identified as the imidacloprid nitroreductase of mammalian liver, producing both nitrosoguanidine and aminoguanidine metabolites.	Nitrosoguanidines	117-133	aldehyde oxidase 1	Homo sapiens	18-21
16202664-1	2006	Complementation analysis of the pso9-1 yeast mutant strain sensitive to photoactivated mono- and bifunctional psoralens, UV-light 254 nm, and nitrosoguanidine, with pso1 to pso8 mutants, confirmed that it contains a novel pso mutation.	Nitrosoguanidines	142-158	Mec3p	Saccharomyces cerevisiae S288C	32-36
12172962-1	2002	A novel mutant isolate of Saccharomyces cerevisiae, sensitive to photoactivated mono- and bi-functional psoralens, to UV at 254 nm (UVC), and to nitrosoguanidine, was found to complement the photoactivated psoralen-sensitivity phenotype conferred by the pso1- pso7 mutations and was therefore named pso8-1.	Nitrosoguanidines	145-161	Cox11p	Saccharomyces cerevisiae S288C	260-264
12172962-1	2002	A novel mutant isolate of Saccharomyces cerevisiae, sensitive to photoactivated mono- and bi-functional psoralens, to UV at 254 nm (UVC), and to nitrosoguanidine, was found to complement the photoactivated psoralen-sensitivity phenotype conferred by the pso1- pso7 mutations and was therefore named pso8-1.	Nitrosoguanidines	145-161	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	299-303
9472073-1	1998	The original pso3-1 mutant isolate of the yeast Saccharomyces cerevisiae exhibits a pleiotropic mutagen-sensitivity phenotype that includes sensitivity to UVA-activated 3-carbethoxypsoralen, to UVC-light, to mono- and bi-functional nitrogen mustard, to paraquat, and to cadmium; on the other hand, it shows hyper-resistance (HYR) to nitrosoguanidine when compared to established wild-type strains.	Nitrosoguanidines	333-349	ribonucleotide-diphosphate reductase subunit RNR4	Saccharomyces cerevisiae S288C	13-17
10943389-1	1999	Aldehyde dehydrogenase, encoded by the aldA gene in Escherichia coli, is inactive in nitrosoguanidine induced mutant strain ECL40 and temperature-sensitive in spontaneous mutant strain JA104.	Nitrosoguanidines	85-101	Aldehyde dehydrogenase	Escherichia coli	0-22
9197471-2	1997	Through mutagenesis of Rat-1 with nitrosoguanidine, we established a mutant cell line, MR-T1.	Nitrosoguanidines	34-50	sorting nexin 27	Rattus norvegicus	87-92
8082194-0	1994	Overexpression of the SNQ3/YAP1 gene confers hyper-resistance to nitrosoguanidine in Saccharomyces cerevisiae via a glutathione-independent mechanism.	Nitrosoguanidines	65-81	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	22-26
8590419-1	1995	Stable mutants of Cryptococcus neoformans (strain CSF-1) induced by treatment with ultraviolet light and nitrosoguanidine were isolated that demonstrated reduced adherence to glial cells in culture.	Nitrosoguanidines	105-121	colony stimulating factor 1	Rattus norvegicus	50-55
7753113-0	1995	SNG1--a new gene involved in nitrosoguanidine resistance in Saccharomyces cerevisiae.	Nitrosoguanidines	29-45	Sng1p	Saccharomyces cerevisiae S288C	0-4
8082194-0	1994	Overexpression of the SNQ3/YAP1 gene confers hyper-resistance to nitrosoguanidine in Saccharomyces cerevisiae via a glutathione-independent mechanism.	Nitrosoguanidines	65-81	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	27-31
2176556-1	1990	The results of complementation analysis of nitrosoguanidine-induced mutants of F-like drd-plasmid pAP18-1 (Tc, ColV) testified to the existence of at least 3 tra regions (tra1, tra2, tra3) and regulating locus fin V in the genome of this plasmid.	Nitrosoguanidines	43-59	phospholipid scramblase 4	Homo sapiens	171-175