PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26420215-4	2015	Activation of protein kinase C (PKC) by the diacylglycerol mimic phorbol-myristic acid resulted in specific and dose-responsive increases in APOBEC3B expression and activity, which could then be strongly suppressed by PKC or NF-kappaB inhibition.	phorbol-12-myristate	65-86	proline rich transmembrane protein 2	Homo sapiens	14-30
27041241-1	2016	The Jun dimerization protein 2 (JDP2) is part of the family of stress-responsible transcription factors such as the activation protein-1, and binds the 12-O-tetradecanoylphorbol-13-acetateresponse element and the cAMP response element.	phorbol-12-myristate	152-177	Jun dimerization protein 2	Homo sapiens	4-30
27041241-1	2016	The Jun dimerization protein 2 (JDP2) is part of the family of stress-responsible transcription factors such as the activation protein-1, and binds the 12-O-tetradecanoylphorbol-13-acetateresponse element and the cAMP response element.	phorbol-12-myristate	152-177	Jun dimerization protein 2	Homo sapiens	32-36
26420215-4	2015	Activation of protein kinase C (PKC) by the diacylglycerol mimic phorbol-myristic acid resulted in specific and dose-responsive increases in APOBEC3B expression and activity, which could then be strongly suppressed by PKC or NF-kappaB inhibition.	phorbol-12-myristate	65-86	proline rich transmembrane protein 2	Homo sapiens	32-35
26420215-4	2015	Activation of protein kinase C (PKC) by the diacylglycerol mimic phorbol-myristic acid resulted in specific and dose-responsive increases in APOBEC3B expression and activity, which could then be strongly suppressed by PKC or NF-kappaB inhibition.	phorbol-12-myristate	65-86	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	Homo sapiens	141-149
26420215-4	2015	Activation of protein kinase C (PKC) by the diacylglycerol mimic phorbol-myristic acid resulted in specific and dose-responsive increases in APOBEC3B expression and activity, which could then be strongly suppressed by PKC or NF-kappaB inhibition.	phorbol-12-myristate	65-86	proline rich transmembrane protein 2	Homo sapiens	218-221
26420215-4	2015	Activation of protein kinase C (PKC) by the diacylglycerol mimic phorbol-myristic acid resulted in specific and dose-responsive increases in APOBEC3B expression and activity, which could then be strongly suppressed by PKC or NF-kappaB inhibition.	phorbol-12-myristate	65-86	nuclear factor kappa B subunit 1	Homo sapiens	225-234
21898481-4	2012	In human cells, phorbol myristic acid induces syndecan-1 shedding, resulting in accumulation of syndecan-1 ectodomains in the medium.	phorbol-12-myristate	16-37	syndecan 1	Homo sapiens	46-56
22906005-3	2012	A double phosphorylation-deficient mutant (S490/543A) of AC2 was insensitive to PMA (phorbol myristic acid) and CCh (carbachol) stimulation, whereas a double phosphomimetic mutant (S490/543D) mimicked the activity of PKC-activated AC2.	phorbol-12-myristate	80-83	adenylate cyclase 2	Homo sapiens	57-60
22906005-3	2012	A double phosphorylation-deficient mutant (S490/543A) of AC2 was insensitive to PMA (phorbol myristic acid) and CCh (carbachol) stimulation, whereas a double phosphomimetic mutant (S490/543D) mimicked the activity of PKC-activated AC2.	phorbol-12-myristate	85-106	adenylate cyclase 2	Homo sapiens	57-60
22548841-1	2012	BACKGROUND: The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway.	phorbol-12-myristate	36-56	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	87-91
22548841-1	2012	BACKGROUND: The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway.	phorbol-12-myristate	36-56	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	97-120
22548841-1	2012	BACKGROUND: The cooperation between phorbol 12-myristate 13-acetate induced protein 1 (NOXA) and myeloid cell leukemia 1 (MCL1) is critical in the intrinsic apoptotic pathway.	phorbol-12-myristate	36-56	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	122-126
21898481-4	2012	In human cells, phorbol myristic acid induces syndecan-1 shedding, resulting in accumulation of syndecan-1 ectodomains in the medium.	phorbol-12-myristate	16-37	syndecan 1	Homo sapiens	96-106
21898481-6	2012	Phorbol myristic acid stimulation significantly decreases DiD (1,1"-dioctadecyl-3,3,3",3"-tetramethylindodicarbocyanine perchlorate)-VLDL binding to cells, and shed syndecan-1 ectodomains bind to VLDL.	phorbol-12-myristate	0-21	CD320 antigen	Mus musculus	133-137
21898481-6	2012	Phorbol myristic acid stimulation significantly decreases DiD (1,1"-dioctadecyl-3,3,3",3"-tetramethylindodicarbocyanine perchlorate)-VLDL binding to cells, and shed syndecan-1 ectodomains bind to VLDL.	phorbol-12-myristate	0-21	syndecan 1	Homo sapiens	165-175
21898481-6	2012	Phorbol myristic acid stimulation significantly decreases DiD (1,1"-dioctadecyl-3,3,3",3"-tetramethylindodicarbocyanine perchlorate)-VLDL binding to cells, and shed syndecan-1 ectodomains bind to VLDL.	phorbol-12-myristate	0-21	CD320 antigen	Mus musculus	196-200
18420182-0	2008	Protein kinase C isozyme-specific potentiation of expressed Ca v 2.3 currents by acetyl-beta-methylcholine and phorbol-12-myristate, 13-acetate.	phorbol-12-myristate	111-131	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	60-68
20385595-3	2010	Phorbol myristic acid and dimethyloxalylglycine differentially stimulate sFlt1 compared to Flt1 expression in vascular endothelial cells and in cytotrophoblasts.	phorbol-12-myristate	0-21	fms related receptor tyrosine kinase 1	Homo sapiens	74-78
21621846-3	2011	Inhibitors of MAPK-Erk kinase (MEK) as well as p38 suppressed TIM-3 transcription in phorbol myristic acid (PMA)-stimulated T cells, but inhibitors of c-Jun NH2-terminal kinase (JNK) did not.	phorbol-12-myristate	85-106	mitogen-activated protein kinase kinase 7	Homo sapiens	31-34
21621846-3	2011	Inhibitors of MAPK-Erk kinase (MEK) as well as p38 suppressed TIM-3 transcription in phorbol myristic acid (PMA)-stimulated T cells, but inhibitors of c-Jun NH2-terminal kinase (JNK) did not.	phorbol-12-myristate	85-106	mitogen-activated protein kinase 14	Homo sapiens	47-50
21621846-3	2011	Inhibitors of MAPK-Erk kinase (MEK) as well as p38 suppressed TIM-3 transcription in phorbol myristic acid (PMA)-stimulated T cells, but inhibitors of c-Jun NH2-terminal kinase (JNK) did not.	phorbol-12-myristate	85-106	hepatitis A virus cellular receptor 2	Homo sapiens	62-67
21621846-3	2011	Inhibitors of MAPK-Erk kinase (MEK) as well as p38 suppressed TIM-3 transcription in phorbol myristic acid (PMA)-stimulated T cells, but inhibitors of c-Jun NH2-terminal kinase (JNK) did not.	phorbol-12-myristate	108-111	mitogen-activated protein kinase kinase 7	Homo sapiens	31-34
21621846-3	2011	Inhibitors of MAPK-Erk kinase (MEK) as well as p38 suppressed TIM-3 transcription in phorbol myristic acid (PMA)-stimulated T cells, but inhibitors of c-Jun NH2-terminal kinase (JNK) did not.	phorbol-12-myristate	108-111	mitogen-activated protein kinase 14	Homo sapiens	47-50
21621846-3	2011	Inhibitors of MAPK-Erk kinase (MEK) as well as p38 suppressed TIM-3 transcription in phorbol myristic acid (PMA)-stimulated T cells, but inhibitors of c-Jun NH2-terminal kinase (JNK) did not.	phorbol-12-myristate	108-111	hepatitis A virus cellular receptor 2	Homo sapiens	62-67
18248623-1	2008	We examined the mechanisms involved in protein kinase C (PKC)-dependent down-regulation of dopamine transporter (DAT) activity and cell surface expression by treating heterologously expressing cells with the clathrin-mediated endocytosis inhibitor concanavalin A (Con A) or the cholesterol depleter/membrane raft disrupter methyl-beta-cyclodextrin (MbetaC) prior to treatment with the PKC activator phorbol 12-myristate, 13-acetate (PMA).	phorbol-12-myristate	399-419	solute carrier family 6 member 3	Homo sapiens	113-116
18420182-1	2008	Protein kinase C (PKC) is implicated in the potentiation of Ca v 2.3 currents by acetyl-beta-methylcholine (MCh), a muscarinic M1 receptor agonist or phorbol-12-myristate, 13-acetate (PMA).	phorbol-12-myristate	150-170	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	60-68
18199973-0	2007	Phorbol 12-myristate 13-acetate-activated protein kinase C increased migratory activity of subconjunctival fibroblasts via stress-activated protein kinase pathways.	phorbol-12-myristate	0-20	mitogen-activated protein kinase 9	Rattus norvegicus	123-154
18313772-2	2008	The endogenous PKC activity, assessed using a cell-based PKC substrate phosphorylation assay, was diminished by PKC inhibitors and enhanced by phorbol myristic acid (PMA).	phorbol-12-myristate	143-164	protein kinase C delta	Homo sapiens	15-18
18313772-2	2008	The endogenous PKC activity, assessed using a cell-based PKC substrate phosphorylation assay, was diminished by PKC inhibitors and enhanced by phorbol myristic acid (PMA).	phorbol-12-myristate	143-164	protein kinase C delta	Homo sapiens	57-60
18313772-2	2008	The endogenous PKC activity, assessed using a cell-based PKC substrate phosphorylation assay, was diminished by PKC inhibitors and enhanced by phorbol myristic acid (PMA).	phorbol-12-myristate	143-164	protein kinase C delta	Homo sapiens	57-60
18313772-2	2008	The endogenous PKC activity, assessed using a cell-based PKC substrate phosphorylation assay, was diminished by PKC inhibitors and enhanced by phorbol myristic acid (PMA).	phorbol-12-myristate	166-169	protein kinase C delta	Homo sapiens	15-18
18313772-2	2008	The endogenous PKC activity, assessed using a cell-based PKC substrate phosphorylation assay, was diminished by PKC inhibitors and enhanced by phorbol myristic acid (PMA).	phorbol-12-myristate	166-169	protein kinase C delta	Homo sapiens	57-60
18313772-2	2008	The endogenous PKC activity, assessed using a cell-based PKC substrate phosphorylation assay, was diminished by PKC inhibitors and enhanced by phorbol myristic acid (PMA).	phorbol-12-myristate	166-169	protein kinase C delta	Homo sapiens	57-60
18313772-6	2008	The inhibition of NT binding by PMA was enhanced by okadaic acid and blocked by PKC inhibitors.	phorbol-12-myristate	32-35	protein kinase C delta	Homo sapiens	80-83
15010576-8	2004	The increase in ECE-1 expression was inhibited in both cell cultures by GF109203X (5 micromol/l), a general PKC inhibitor, while addition of 10 nmol/l phorbol myristic acid to EA.hy926 cells or HUVEC growing on medium containing 5.5 mmol/l glucose increased ECE-1 expression to a level similar to that of cells conditioned in high glucose.	phorbol-12-myristate	151-172	endothelin converting enzyme 1	Homo sapiens	16-21
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	phorbol-12-myristate	64-84	granulin	Mus musculus	112-116
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	phorbol-12-myristate	64-84	granulin	Mus musculus	182-186
16704976-0	2006	Inhibitory role of Ser-425 of the alpha1 2.2 subunit in the enhancement of Cav 2.2 currents by phorbol-12-myristate, 13-acetate.	phorbol-12-myristate	95-115	calcium channel, voltage-dependent, N type, alpha 1B subunit S homeolog	Xenopus laevis	75-82
16704976-1	2006	Voltage-gated calcium channels (Ca(v)) 2.2 currents are potentiated by phorbol-12-myristate, 13-acetate (PMA), whereas Ca(v) 2.3 currents are increased by both PMA and acetyl-beta-methylcholine (MCh).	phorbol-12-myristate	71-91	calcium channel, voltage-dependent, N type, alpha 1B subunit S homeolog	Xenopus laevis	32-42
15741241-5	2005	The addition of phorbol 12-myristate,13-acetate (PMA) and forskolin to hepatocytes increased Hal mRNA concentration by 100 and 40%, respectively.	phorbol-12-myristate	16-36	histidine ammonia lyase	Rattus norvegicus	93-96
15492115-7	2005	Furthermore, we overexpressed Fra-2 in human melanoma cells by using a Fra-2 expression construct and both AP-1 transcriptional activity and 12-O-tetradecanoylphorbol-induced transcriptional transactivation were reduced significantly, whereas MHC class I antigen and Fas/CD95 levels were elevated to 2.0 and 1.8 times of control, respectively.	phorbol-12-myristate	141-166	FOS like 2, AP-1 transcription factor subunit	Homo sapiens	30-35
16211248-4	2005	RGPR-p117 mRNA was expressed in NRK52E cells, and its expression was stimulated by culture with parathyroid hormone (10(-7) M) or phorbol 12-myristate (10(-6) M).	phorbol-12-myristate	130-150	SEC16 homolog B, endoplasmic reticulum export factor	Rattus norvegicus	0-9
15648090-5	2005	This constitutive shedding corresponding to the basal level of soluble syndecan-1 ectodomain was significantly increased when cells were stimulated with P. gingivalis LPS and reached a level comparable to that caused by phorbol myristic acid (PMA), an activator of protein kinase C (PKC) which is well known as a shedding agonist.	phorbol-12-myristate	220-241	syndecan 1	Homo sapiens	71-81
15648090-5	2005	This constitutive shedding corresponding to the basal level of soluble syndecan-1 ectodomain was significantly increased when cells were stimulated with P. gingivalis LPS and reached a level comparable to that caused by phorbol myristic acid (PMA), an activator of protein kinase C (PKC) which is well known as a shedding agonist.	phorbol-12-myristate	243-246	syndecan 1	Homo sapiens	71-81
15652337-7	2005	The effect of myocilin on focal adhesions could be overcome by treating cells with either phorbol 12-myristate (PMA) or oleoyl-L-alpha-lysophosphatidic acid (LPA).	phorbol-12-myristate	90-110	myocilin	Homo sapiens	14-22
15652337-7	2005	The effect of myocilin on focal adhesions could be overcome by treating cells with either phorbol 12-myristate (PMA) or oleoyl-L-alpha-lysophosphatidic acid (LPA).	phorbol-12-myristate	112-115	myocilin	Homo sapiens	14-22
15691336-10	2005	Moreover, herein it was established that the core AP-1 element mediates phorbol myristic acid-induction of Prm3 activity hence providing a mechanistic explanation of phorbol ester up-regulation of TPbeta mRNA expression.	phorbol-12-myristate	72-93	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	50-54
15691336-10	2005	Moreover, herein it was established that the core AP-1 element mediates phorbol myristic acid-induction of Prm3 activity hence providing a mechanistic explanation of phorbol ester up-regulation of TPbeta mRNA expression.	phorbol-12-myristate	72-93	protamine 3	Homo sapiens	107-111
15010576-8	2004	The increase in ECE-1 expression was inhibited in both cell cultures by GF109203X (5 micromol/l), a general PKC inhibitor, while addition of 10 nmol/l phorbol myristic acid to EA.hy926 cells or HUVEC growing on medium containing 5.5 mmol/l glucose increased ECE-1 expression to a level similar to that of cells conditioned in high glucose.	phorbol-12-myristate	151-172	endothelin converting enzyme 1	Homo sapiens	258-263
11543740-4	2001	RESULTS: Receptor for activated C kinase-1 was located exclusively in membranes and, in control brains, the levels of RACK1 that coimmunoprecipitated with most PKC isozymes were increased by stimulation with the PKC activator, phorbol 12-myristate, 13-acetate (PMA).	phorbol-12-myristate	227-247	receptor for activated C kinase 1	Homo sapiens	9-42
12388354-4	2002	Rat lymphocytes activated ex vivo with phorbol 12-myristate, 13-acetate increased K(f,c) in isolated lungs independently of I/R, and this increase was prevented by pretreating lungs with anti-CD40.	phorbol-12-myristate	39-59	CD40 molecule	Rattus norvegicus	192-196
11543740-4	2001	RESULTS: Receptor for activated C kinase-1 was located exclusively in membranes and, in control brains, the levels of RACK1 that coimmunoprecipitated with most PKC isozymes were increased by stimulation with the PKC activator, phorbol 12-myristate, 13-acetate (PMA).	phorbol-12-myristate	227-247	receptor for activated C kinase 1	Homo sapiens	118-123
11490365-10	2001	Both phorbol 12-myristate, 13-acetate and bryostatin-1, which selectively activate PKC epsilon in T84 cells, markedly attenuated the Isc response to ischemia.	phorbol-12-myristate	5-25	protein kinase C epsilon	Homo sapiens	83-94
11108138-5	2000	The addition of a combination of isoproterenol and iodoclonidine or a combination of 8-Bromo-cAMP (8-Br-cAMP) and phorbol 12-myristate (PMA) synergistically stimulated the expression of the ANG-GH fusion gene as compared to the addition of isoproterenol, iodoclonidine, 8-Br-cAMP or PMA alone.	phorbol-12-myristate	114-134	angiotensinogen	Homo sapiens	190-193
11467851-4	2001	Phorbol 12-myristate, 13-acetate (PMA)-stimulated APP secretion, which was reduced by a general PKC inhibitor bisindoylmaleimide I, but not by Go 6976, which inhibits PKCalpha, beta, gamma, and mu.	phorbol-12-myristate	0-20	protein kinase C alpha	Homo sapiens	96-99
11108138-5	2000	The addition of a combination of isoproterenol and iodoclonidine or a combination of 8-Bromo-cAMP (8-Br-cAMP) and phorbol 12-myristate (PMA) synergistically stimulated the expression of the ANG-GH fusion gene as compared to the addition of isoproterenol, iodoclonidine, 8-Br-cAMP or PMA alone.	phorbol-12-myristate	136-139	angiotensinogen	Homo sapiens	190-193
11108138-6	2000	Furthermore, the addition of NE, 8-Br-cAMP or PMA stimulated the expression of pOGH (rANG N-806/-779/-53/+18), a fusion gene containing the putative cAMP responsive element (CRE, ANG N-806/-779) upstream of the ANG promoter (ANG N-53/+18) in OK cells, but had no effect on the expression of fusion genes containing the mutant of the CRE.	phorbol-12-myristate	46-49	angiotensinogen	Homo sapiens	86-89
11108138-6	2000	Furthermore, the addition of NE, 8-Br-cAMP or PMA stimulated the expression of pOGH (rANG N-806/-779/-53/+18), a fusion gene containing the putative cAMP responsive element (CRE, ANG N-806/-779) upstream of the ANG promoter (ANG N-53/+18) in OK cells, but had no effect on the expression of fusion genes containing the mutant of the CRE.	phorbol-12-myristate	46-49	angiotensinogen	Homo sapiens	179-182
11108138-6	2000	Furthermore, the addition of NE, 8-Br-cAMP or PMA stimulated the expression of pOGH (rANG N-806/-779/-53/+18), a fusion gene containing the putative cAMP responsive element (CRE, ANG N-806/-779) upstream of the ANG promoter (ANG N-53/+18) in OK cells, but had no effect on the expression of fusion genes containing the mutant of the CRE.	phorbol-12-myristate	46-49	angiotensinogen	Homo sapiens	179-182
10888256-7	2000	The levels of VEGF mRNA in CEVM were significantly augmented by forskolin (100 microM), or phorbol 12-myristate, 13-acetate (200 nM) in a time-dependent manner in CEVM.	phorbol-12-myristate	91-111	vascular endothelial growth factor A	Gallus gallus	14-18
10334302-9	1999	Whereas CHO cells expressing the growth hormone receptor showed marked downregulation of ligand binding after exposure to dexamethasone (DEX) or phorbol myristic acid (PMA), PMA had no effect on expression of ObRa or ObRb, and DEX reduced binding to cells expressing ObRb by 15%.	phorbol-12-myristate	168-171	growth hormone receptor	Cricetulus griseus	33-56
10706056-2	2000	METHODS: Intracellular interleukin- (IL) 2 was measured in phorbol myristic acid-ionomycin-stimulated peripheral lymphocytes by flow cytometry, after isolation from 14 renal transplant recipients receiving CSA+prednisone, and double-blind rapamycin (rapamycin:placebo=4:1).	phorbol-12-myristate	59-80	interleukin 2	Homo sapiens	23-42
10688914-8	2000	Bypass of the antigen receptor signaling pathways by treatment of cells with phorbol myristic acid and ionomycin rescued up-regulation of Btk protein in xid splenic B cells.	phorbol-12-myristate	77-98	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	138-141
10446305-3	1999	In the present study, the transport of succinate in Xenopus oocytes expressing NaDC-1 was inhibited up to 95% by two activators of protein kinase C, phorbol 12-myristate, 13-acetate (PMA) and sn-1, 2-dioctanoylglycerol (DOG).	phorbol-12-myristate	149-169	solute carrier family 13 member 2L homeolog	Xenopus laevis	79-85
10334302-9	1999	Whereas CHO cells expressing the growth hormone receptor showed marked downregulation of ligand binding after exposure to dexamethasone (DEX) or phorbol myristic acid (PMA), PMA had no effect on expression of ObRa or ObRb, and DEX reduced binding to cells expressing ObRb by 15%.	phorbol-12-myristate	145-166	growth hormone receptor	Cricetulus griseus	33-56
11324578-2	1998	The results were as follows: (1) PKC agonist phorbol-12-myristate, 13-acetate (PMA) stimulated the glutamate uptake in the rat cerebral cortex synaptosomes and cell line of BT-325, but not in the cell line of SK-N-SH.	phorbol-12-myristate	45-65	protein kinase C, gamma	Rattus norvegicus	33-36
9886846-3	1999	Activation of protein kinase C (PKC) by phorbol myristic acid significantly stimulated GnRHR-luciferase reporter gene (GnRHR-Luc) activity, but did not potentiate the stimulation of GnRHR-Luc activity by the GnRH agonist, buserelin (GnRH-A).	phorbol-12-myristate	40-61	protein kinase C, gamma	Rattus norvegicus	14-30
9886846-3	1999	Activation of protein kinase C (PKC) by phorbol myristic acid significantly stimulated GnRHR-luciferase reporter gene (GnRHR-Luc) activity, but did not potentiate the stimulation of GnRHR-Luc activity by the GnRH agonist, buserelin (GnRH-A).	phorbol-12-myristate	40-61	protein kinase C, gamma	Rattus norvegicus	32-35
9886846-3	1999	Activation of protein kinase C (PKC) by phorbol myristic acid significantly stimulated GnRHR-luciferase reporter gene (GnRHR-Luc) activity, but did not potentiate the stimulation of GnRHR-Luc activity by the GnRH agonist, buserelin (GnRH-A).	phorbol-12-myristate	40-61	gonadotropin releasing hormone receptor	Rattus norvegicus	87-92
9886846-3	1999	Activation of protein kinase C (PKC) by phorbol myristic acid significantly stimulated GnRHR-luciferase reporter gene (GnRHR-Luc) activity, but did not potentiate the stimulation of GnRHR-Luc activity by the GnRH agonist, buserelin (GnRH-A).	phorbol-12-myristate	40-61	gonadotropin releasing hormone receptor	Rattus norvegicus	119-124
9886846-3	1999	Activation of protein kinase C (PKC) by phorbol myristic acid significantly stimulated GnRHR-luciferase reporter gene (GnRHR-Luc) activity, but did not potentiate the stimulation of GnRHR-Luc activity by the GnRH agonist, buserelin (GnRH-A).	phorbol-12-myristate	40-61	gonadotropin releasing hormone receptor	Rattus norvegicus	119-124
9886846-3	1999	Activation of protein kinase C (PKC) by phorbol myristic acid significantly stimulated GnRHR-luciferase reporter gene (GnRHR-Luc) activity, but did not potentiate the stimulation of GnRHR-Luc activity by the GnRH agonist, buserelin (GnRH-A).	phorbol-12-myristate	40-61	gonadotropin releasing hormone 1	Rattus norvegicus	87-91
9886846-3	1999	Activation of protein kinase C (PKC) by phorbol myristic acid significantly stimulated GnRHR-luciferase reporter gene (GnRHR-Luc) activity, but did not potentiate the stimulation of GnRHR-Luc activity by the GnRH agonist, buserelin (GnRH-A).	phorbol-12-myristate	40-61	gonadotropin releasing hormone 1	Rattus norvegicus	119-123
9886846-4	1999	Inhibition of PKC by PKC inhibitor (GF 109203X) or depletion of PKC blocked phorbol myristic acid- or GnRH-A-stimulated GnRHR-Luc activity, but did not affect (Bu)2cAMP-stimulated GnRHR-Luc activity.	phorbol-12-myristate	76-97	protein kinase C, gamma	Rattus norvegicus	14-17
9886846-4	1999	Inhibition of PKC by PKC inhibitor (GF 109203X) or depletion of PKC blocked phorbol myristic acid- or GnRH-A-stimulated GnRHR-Luc activity, but did not affect (Bu)2cAMP-stimulated GnRHR-Luc activity.	phorbol-12-myristate	76-97	gonadotropin releasing hormone receptor	Rattus norvegicus	120-125
9844106-4	1998	During a 3-day treatment with phorbol 12-myristate, 13-acetate (PMA), which induces differentiation of FLG 29.1 cells toward an osteoclast-like phenotype, the levels of Src and Fyn increased and the levels of Lyn decreased.	phorbol-12-myristate	30-50	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	169-172
9844106-4	1998	During a 3-day treatment with phorbol 12-myristate, 13-acetate (PMA), which induces differentiation of FLG 29.1 cells toward an osteoclast-like phenotype, the levels of Src and Fyn increased and the levels of Lyn decreased.	phorbol-12-myristate	30-50	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	177-180
9844106-4	1998	During a 3-day treatment with phorbol 12-myristate, 13-acetate (PMA), which induces differentiation of FLG 29.1 cells toward an osteoclast-like phenotype, the levels of Src and Fyn increased and the levels of Lyn decreased.	phorbol-12-myristate	30-50	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	209-212
9515165-5	1998	Moreover, the PKC-activating phorbol ester, phorbol-12-myristate, 13-acetate (PMA) caused an increase in PDE-4 activity, similar to that observed in cells challenged with anti-CD3 monoclonal antibodies and which was not additive with cochallenge using anti-CD3 antibodies.	phorbol-12-myristate	44-64	CD3 antigen, epsilon polypeptide	Mus musculus	176-179
9515165-5	1998	Moreover, the PKC-activating phorbol ester, phorbol-12-myristate, 13-acetate (PMA) caused an increase in PDE-4 activity, similar to that observed in cells challenged with anti-CD3 monoclonal antibodies and which was not additive with cochallenge using anti-CD3 antibodies.	phorbol-12-myristate	44-64	CD3 antigen, epsilon polypeptide	Mus musculus	257-260
9144337-5	1997	Brief treatment of parathyroid and HEK-CaR cells with an activator of protein kinase C (PKC), phorbol 12-myristate,13-acetate (PMA), stimulated PLD activity at both low and high Ca2+(o).	phorbol-12-myristate	94-114	calcium sensing receptor	Homo sapiens	39-42
9144337-5	1997	Brief treatment of parathyroid and HEK-CaR cells with an activator of protein kinase C (PKC), phorbol 12-myristate,13-acetate (PMA), stimulated PLD activity at both low and high Ca2+(o).	phorbol-12-myristate	94-114	proline rich transmembrane protein 2	Homo sapiens	70-86
9144337-5	1997	Brief treatment of parathyroid and HEK-CaR cells with an activator of protein kinase C (PKC), phorbol 12-myristate,13-acetate (PMA), stimulated PLD activity at both low and high Ca2+(o).	phorbol-12-myristate	94-114	proline rich transmembrane protein 2	Homo sapiens	88-91
9144337-5	1997	Brief treatment of parathyroid and HEK-CaR cells with an activator of protein kinase C (PKC), phorbol 12-myristate,13-acetate (PMA), stimulated PLD activity at both low and high Ca2+(o).	phorbol-12-myristate	94-114	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	144-147
9040478-8	1997	Smaller, but significant, increases in IL-8 and MCP-1 resulted from CM phorbol myristic acid-stimulated T-lymphocytes.	phorbol-12-myristate	71-92	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
9047000-4	1997	In vitro treatment with a phorbol ester (phorbol 12-myristate, 13-acetate), but not a cAMP analogue (8-bromo-cAMP), significantly increased uPA mRNA levels in both granulosa and theca tissue from the largest and second-largest preovulatory follicles.	phorbol-12-myristate	41-61	plasminogen activator, urokinase	Gallus gallus	140-143
9099897-9	1997	Treatment of LNCaP and PC-3 cells with the phorbol ester 12-O-tetradecanoylphorbol (TPA) caused the same effect on mAAT activity and mRNA level as prolactin.	phorbol-12-myristate	57-82	serine (or cysteine) preptidase inhibitor, clade A, member 1B	Mus musculus	115-119
9099897-9	1997	Treatment of LNCaP and PC-3 cells with the phorbol ester 12-O-tetradecanoylphorbol (TPA) caused the same effect on mAAT activity and mRNA level as prolactin.	phorbol-12-myristate	57-82	prolactin	Homo sapiens	147-156
9040478-8	1997	Smaller, but significant, increases in IL-8 and MCP-1 resulted from CM phorbol myristic acid-stimulated T-lymphocytes.	phorbol-12-myristate	71-92	C-C motif chemokine ligand 2	Homo sapiens	48-53
8648910-6	1996	Short term incubation (5 min) with the active phorbol ester, phorbol 12-myristate, 13-acetate (PMA), 10(-7) M, caused a significant stimulation of the Na-HCO3 cotransporter activity as compared to controls.	phorbol-12-myristate	61-81	electrogenic sodium bicarbonate cotransporter 1	Oryctolagus cuniculus	151-172
7874076-4	1994	The protein kinase C (PKC) activator phorbol myristic acid (PMA) stimulated PGE2 production in both strains but not IL-1 production, suggesting that signalling pathways other than PKC may be involved in IL-1 production.	phorbol-12-myristate	37-58	interleukin 1 complex	Mus musculus	203-207
7666012-4	1995	Protein kinase C activation with phorbol 12-myristate, 13-acetate (100 nM) decreased cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by 71 +/- 5% and 60 +/- 16%, respectively, within 3 h. mRNA levels recovered to control levels by 18-24 h, however, consistent with downregulation of protein kinase C. Furthermore, after depletion of protein kinase C with a 24-h preincubation with phorbol diesters, taurocholate (25 microM) repressed cholesterol 7 alpha-hydroxylase mRNA by only 14 +/- 17%.	phorbol-12-myristate	33-53	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	85-116
7666012-4	1995	Protein kinase C activation with phorbol 12-myristate, 13-acetate (100 nM) decreased cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by 71 +/- 5% and 60 +/- 16%, respectively, within 3 h. mRNA levels recovered to control levels by 18-24 h, however, consistent with downregulation of protein kinase C. Furthermore, after depletion of protein kinase C with a 24-h preincubation with phorbol diesters, taurocholate (25 microM) repressed cholesterol 7 alpha-hydroxylase mRNA by only 14 +/- 17%.	phorbol-12-myristate	33-53	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	452-483
7857990-1	1995	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate (PMA) either inhibits or stimulates phospholipase C-mediated hydrolysis of phosphatidylethanolamine in the absence or presence of ethanol, respectively.	phorbol-12-myristate	53-73	proline rich transmembrane protein 2	Homo sapiens	20-36
7857990-1	1995	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate (PMA) either inhibits or stimulates phospholipase C-mediated hydrolysis of phosphatidylethanolamine in the absence or presence of ethanol, respectively.	phorbol-12-myristate	53-73	proline rich transmembrane protein 2	Homo sapiens	38-41
7857990-1	1995	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate (PMA) either inhibits or stimulates phospholipase C-mediated hydrolysis of phosphatidylethanolamine in the absence or presence of ethanol, respectively.	phorbol-12-myristate	75-78	proline rich transmembrane protein 2	Homo sapiens	20-36
7857990-1	1995	In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate (PMA) either inhibits or stimulates phospholipase C-mediated hydrolysis of phosphatidylethanolamine in the absence or presence of ethanol, respectively.	phorbol-12-myristate	75-78	proline rich transmembrane protein 2	Homo sapiens	38-41
7857990-2	1995	Here, we demonstrate that the specific PKC inhibitor bisindolylmaleimide GF 109203X prevents only the inhibitory, but not the stimulatory, PMA effect.	phorbol-12-myristate	139-142	proline rich transmembrane protein 2	Homo sapiens	39-42
7484154-1	1995	Intrathecal administration (ith) of phorbol 12-myristate (TPA), an activator of protein kinase C, (31.24, 26.5, 125 and 250 ng/10 micrograms) to conscious rats produced a marked dose-dependent pressor effect without significant change in heart rate (HR).	phorbol-12-myristate	36-56	plasminogen activator, tissue type	Rattus norvegicus	58-61
7874076-4	1994	The protein kinase C (PKC) activator phorbol myristic acid (PMA) stimulated PGE2 production in both strains but not IL-1 production, suggesting that signalling pathways other than PKC may be involved in IL-1 production.	phorbol-12-myristate	60-63	interleukin 1 complex	Mus musculus	203-207
8161792-5	1994	After treatment of HL-60/BCL2 cells with all-trans retinoic acid or phorbol myristic acid, Bcl2 levels did not decrease as in normal HL-60 cells but, rather, increased because of activation of the viral promoter.	phorbol-12-myristate	68-89	BCL2 apoptosis regulator	Homo sapiens	25-29
8207213-3	1994	The following experiments both confirm that the addition of ceramide to cells can activate NF-kappa B and demonstrate that a 48-h pretreatment with phorbol 12-myristate (PMA) results in the loss of the ceramide-induced NF-kappa B response.	phorbol-12-myristate	148-168	nuclear factor kappa B subunit 1	Homo sapiens	91-101
8207213-3	1994	The following experiments both confirm that the addition of ceramide to cells can activate NF-kappa B and demonstrate that a 48-h pretreatment with phorbol 12-myristate (PMA) results in the loss of the ceramide-induced NF-kappa B response.	phorbol-12-myristate	148-168	nuclear factor kappa B subunit 1	Homo sapiens	219-229
8207213-3	1994	The following experiments both confirm that the addition of ceramide to cells can activate NF-kappa B and demonstrate that a 48-h pretreatment with phorbol 12-myristate (PMA) results in the loss of the ceramide-induced NF-kappa B response.	phorbol-12-myristate	170-173	nuclear factor kappa B subunit 1	Homo sapiens	91-101
8207213-3	1994	The following experiments both confirm that the addition of ceramide to cells can activate NF-kappa B and demonstrate that a 48-h pretreatment with phorbol 12-myristate (PMA) results in the loss of the ceramide-induced NF-kappa B response.	phorbol-12-myristate	170-173	nuclear factor kappa B subunit 1	Homo sapiens	219-229
8161792-5	1994	After treatment of HL-60/BCL2 cells with all-trans retinoic acid or phorbol myristic acid, Bcl2 levels did not decrease as in normal HL-60 cells but, rather, increased because of activation of the viral promoter.	phorbol-12-myristate	68-89	BCL2 apoptosis regulator	Homo sapiens	91-95
8454058-1	1993	Phorbol esters such as phorbol 12-myristate,13-acetate (PMA) are potent activators of protein kinase C (PKC), and activate all PKC isozymes except zeta and lambda.	phorbol-12-myristate	23-43	protein kinase C alpha	Homo sapiens	104-107
8325843-5	1993	Fetal calf serum, insulin, IGF-I, 12-O-tetradecanoylphorbol (TPA), and cycloheximide induced a 2.2-kilobase c-fos transcript in neurons.	phorbol-12-myristate	34-59	FBJ osteosarcoma oncogene	Mus musculus	108-113
8464239-2	1993	We have demonstrated before that tumour necrosis factor alpha (TNF-alpha), in combination with low dose phorbol myristic acid (PMA) (0.1 ng/ml), can induce proliferation in these purified B-cell populations and that this TNF-alpha-induced proliferation is completely inhibited by the addition of interleukin 4 (IL-4).	phorbol-12-myristate	104-125	tumor necrosis factor	Homo sapiens	221-230
8464239-2	1993	We have demonstrated before that tumour necrosis factor alpha (TNF-alpha), in combination with low dose phorbol myristic acid (PMA) (0.1 ng/ml), can induce proliferation in these purified B-cell populations and that this TNF-alpha-induced proliferation is completely inhibited by the addition of interleukin 4 (IL-4).	phorbol-12-myristate	127-130	tumor necrosis factor	Homo sapiens	221-230
8464239-2	1993	We have demonstrated before that tumour necrosis factor alpha (TNF-alpha), in combination with low dose phorbol myristic acid (PMA) (0.1 ng/ml), can induce proliferation in these purified B-cell populations and that this TNF-alpha-induced proliferation is completely inhibited by the addition of interleukin 4 (IL-4).	phorbol-12-myristate	127-130	interleukin 4	Homo sapiens	296-309
8464239-2	1993	We have demonstrated before that tumour necrosis factor alpha (TNF-alpha), in combination with low dose phorbol myristic acid (PMA) (0.1 ng/ml), can induce proliferation in these purified B-cell populations and that this TNF-alpha-induced proliferation is completely inhibited by the addition of interleukin 4 (IL-4).	phorbol-12-myristate	127-130	interleukin 4	Homo sapiens	311-315
7680921-3	1993	CD68 transcripts are constitutively present in the promonocyte cell line U937 and are upregulated by phorbol myristic acid (PMA).	phorbol-12-myristate	101-122	CD68 molecule	Homo sapiens	0-4
7680921-3	1993	CD68 transcripts are constitutively present in the promonocyte cell line U937 and are upregulated by phorbol myristic acid (PMA).	phorbol-12-myristate	124-127	CD68 molecule	Homo sapiens	0-4
8454058-1	1993	Phorbol esters such as phorbol 12-myristate,13-acetate (PMA) are potent activators of protein kinase C (PKC), and activate all PKC isozymes except zeta and lambda.	phorbol-12-myristate	23-43	protein kinase C alpha	Homo sapiens	127-130
1280118-2	1992	Prior exposure of cells to 6 x 10(-7) M phorbol 12-myristate, 13-acetate for 15 min resulted in a 40-50% inhibition of CGRP II-dependent cAMP stimulation.	phorbol-12-myristate	40-60	calcitonin related polypeptide beta	Homo sapiens	119-126
1332716-10	1992	Additionally, as found for Ang II, preincubation of VSMC with either phorbol 12-myristate, 13-acetate, forskolin or 8-bromo-cyclic GMP inhibited LDL- and HDL-induced accumulation of [3H]-inositol monophosphate.	phorbol-12-myristate	69-89	angiotensinogen	Homo sapiens	27-33
1786996-9	1991	In contrast, addition of phorbol myristic acid (PMA) led to increased TNF alpha mRNA at 5 h while the combination of PMA and ionomycin increased the level of specific mRNA detected at 1 h, 5 h and 24 h. From genomic analysis ovine TNF alpha appears to exist as a single copy.	phorbol-12-myristate	25-46	tumor necrosis factor	Homo sapiens	70-79
1800956-4	1991	The effect of gastrin was comparable to the stimulation induced by phorbol 12-myristate, 13-acetate (PMA), a strong activator of protein kinase C. The increase in protein synthesis induced by gastrin was totally abolished by 1-(5-isoquinolinyl)-2-methylpiperazine, an inhibitor of protein kinase C activity.	phorbol-12-myristate	67-87	gastrin	Rattus norvegicus	192-199
1498520-3	1992	PKC is involved in many cell processes such as the transduction of hormonal signals and the machinery of cellular secretion and is activated by diacylglycerol and by a number of phorbol esters, including phorbol myristic acid (PMA).	phorbol-12-myristate	204-225	proline rich transmembrane protein 2	Homo sapiens	0-3
1498520-3	1992	PKC is involved in many cell processes such as the transduction of hormonal signals and the machinery of cellular secretion and is activated by diacylglycerol and by a number of phorbol esters, including phorbol myristic acid (PMA).	phorbol-12-myristate	227-230	proline rich transmembrane protein 2	Homo sapiens	0-3
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	phorbol-12-myristate	96-117	interleukin 1 alpha	Homo sapiens	30-40
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	phorbol-12-myristate	96-117	interleukin 1 beta	Homo sapiens	46-55
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	phorbol-12-myristate	119-122	interleukin 1 alpha	Homo sapiens	30-40
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	phorbol-12-myristate	119-122	interleukin 1 beta	Homo sapiens	46-55
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	phorbol-12-myristate	127-130	interleukin 1 alpha	Homo sapiens	30-40
1769692-6	1991	The analysis of expression of IL-1 alpha- and IL-1 beta-specific mRNA in response to endotoxin, phorbol myristic acid (PMA) or PMA plus ionomycin revealed a distinct pattern of differential regulation of the two genes.	phorbol-12-myristate	127-130	interleukin 1 beta	Homo sapiens	46-55
1786996-9	1991	In contrast, addition of phorbol myristic acid (PMA) led to increased TNF alpha mRNA at 5 h while the combination of PMA and ionomycin increased the level of specific mRNA detected at 1 h, 5 h and 24 h. From genomic analysis ovine TNF alpha appears to exist as a single copy.	phorbol-12-myristate	25-46	tumor necrosis factor	Homo sapiens	231-240
1786996-9	1991	In contrast, addition of phorbol myristic acid (PMA) led to increased TNF alpha mRNA at 5 h while the combination of PMA and ionomycin increased the level of specific mRNA detected at 1 h, 5 h and 24 h. From genomic analysis ovine TNF alpha appears to exist as a single copy.	phorbol-12-myristate	48-51	tumor necrosis factor	Homo sapiens	70-79
2162944-2	1990	Preincubation with neurotensin or phorbol 12-myristate, 13-acetate decreased the number of cell surface neurotensin receptors and neurotensin-induced increases of inositol trisphosphates and [Ca2+]i.	phorbol-12-myristate	34-54	neurotensin	Homo sapiens	104-115
1953275-6	1991	The influence of protein kinase C and that of G proteins on the mitogenesis in cells stimulated by thrombin or AVP was determined by pretreating cells with phorbol 12-myristate, 13-acetate (TPA) and pertussis toxin, respectively.	phorbol-12-myristate	156-176	coagulation factor II	Rattus norvegicus	99-107
1953275-6	1991	The influence of protein kinase C and that of G proteins on the mitogenesis in cells stimulated by thrombin or AVP was determined by pretreating cells with phorbol 12-myristate, 13-acetate (TPA) and pertussis toxin, respectively.	phorbol-12-myristate	156-176	arginine vasopressin	Rattus norvegicus	111-114
1711295-4	1991	Attachment of phorbol 12-myristate, 13-acetate (PMA)-stimulated W256 cells to endothelial monolayers was increased 1.8 +/- 0.1-fold and damage (3H-2-deoxyglucose release from labeled endothelium) 1.4 +/- 0.1-fold after 4-hour pretreatment of the endothelium with 10 ng/ml recombinant human interleukin-1 alpha (rIL-1 alpha).	phorbol-12-myristate	14-34	interleukin 1 alpha	Homo sapiens	290-309
1711295-4	1991	Attachment of phorbol 12-myristate, 13-acetate (PMA)-stimulated W256 cells to endothelial monolayers was increased 1.8 +/- 0.1-fold and damage (3H-2-deoxyglucose release from labeled endothelium) 1.4 +/- 0.1-fold after 4-hour pretreatment of the endothelium with 10 ng/ml recombinant human interleukin-1 alpha (rIL-1 alpha).	phorbol-12-myristate	14-34	interleukin 1 alpha	Rattus norvegicus	311-322
2162944-7	1990	Incubation with carbachol, ATP or phorbol 12-myristate, 13-acetate desensitized the subsequent [Ca2+]i response to neurotensin.	phorbol-12-myristate	34-54	neurotensin	Homo sapiens	115-126
1676985-7	1991	The addition of small amounts of phorbol 12-myristate, 13-acetate, but not Ca2+ ionophore A23187, is able to overcome the defect, thereby suggesting a direct PKC involvement.	phorbol-12-myristate	33-53	proline rich transmembrane protein 2	Homo sapiens	158-161
2162944-2	1990	Preincubation with neurotensin or phorbol 12-myristate, 13-acetate decreased the number of cell surface neurotensin receptors and neurotensin-induced increases of inositol trisphosphates and [Ca2+]i.	phorbol-12-myristate	34-54	neurotensin	Homo sapiens	104-115
2159182-4	1990	The protein kinase C activator, phorbol 12-myristate, 13-acetate, mimicked PAF in the binding assay.	phorbol-12-myristate	32-52	PCNA clamp associated factor	Homo sapiens	75-78
2344355-6	1990	Phorbol 12-myristate (PM) also had a similar effect on PLA2 activity.	phorbol-12-myristate	0-20	phospholipase A2 group IB	Homo sapiens	55-59
2344355-6	1990	Phorbol 12-myristate (PM) also had a similar effect on PLA2 activity.	phorbol-12-myristate	22-24	phospholipase A2 group IB	Homo sapiens	55-59
34837563-0	2022	Correction to: Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells.	phorbol-12-myristate	73-98	AKT serine/threonine kinase 1	Homo sapiens	52-55
1688390-1	1990	Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion.	phorbol-12-myristate	42-62	protein kinase C, gamma	Rattus norvegicus	84-100
1688390-1	1990	Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion.	phorbol-12-myristate	42-62	protein kinase C, gamma	Rattus norvegicus	102-106
2647723-3	1989	Treatment of monocytes with phorbol myristic acid or cycloheximide induces both genes, while lipopolysaccharide selectively and transiently induces G-CSF transcripts.	phorbol-12-myristate	28-49	colony stimulating factor 3	Homo sapiens	148-153
2475257-0	1989	Anti-CD4 monoclonal antibodies enhance phorbol 12-myristate, 13-acetate-induced activation of human T cells.	phorbol-12-myristate	39-59	CD4 molecule	Homo sapiens	5-8
2475257-3	1989	In the present study, we examined different anti-CD4 monoclonal antibodies (mAbs) for their ability to influence lymphocyte proliferation induced by phorbol 12-myristate, 13-acetate (PMA).	phorbol-12-myristate	149-169	CD4 molecule	Homo sapiens	49-52
2540997-1	1989	We have examined the effects of a biologically active tumor promoting phorbol ester (phorbol 12-myristate, 13-acetate (PMA] which activates protein kinase C (PKC) on melanotropin receptor function and cell growth in the M2R mouse melanoma cell clone.	phorbol-12-myristate	85-105	melanocortin 1 receptor	Homo sapiens	166-187
3011895-5	1986	The binding of 125I-IL 1-beta to VDS-O cells was also inhibited by F(ab)"2 fragments of anti-human IL 1 and recombinant human IL 1-alpha, as well as by unlabeled human IL 1-beta but not by recombinant lymphotoxin, recombinant tumor necrosis factor, or phorbol myristic acid, suggesting that IL 1-alpha and IL 1-beta bind specifically to the same receptor.	phorbol-12-myristate	252-273	interleukin 1 beta	Homo sapiens	20-29
2846820-1	1988	In this study we have characterized and compared the regulation of the HT29 cell vasoactive intestinal peptide receptor/adenylate cyclase system (VIP-R/AC) by the VIP-R agonist peptide histidineisoleucineamide (PHI) and by activators of protein kinase C (PKC) including phorbol 12-myristate, 13-acetate (PMA) and mezerein.	phorbol-12-myristate	270-290	vasoactive intestinal peptide receptor 1	Homo sapiens	146-154
2846820-1	1988	In this study we have characterized and compared the regulation of the HT29 cell vasoactive intestinal peptide receptor/adenylate cyclase system (VIP-R/AC) by the VIP-R agonist peptide histidineisoleucineamide (PHI) and by activators of protein kinase C (PKC) including phorbol 12-myristate, 13-acetate (PMA) and mezerein.	phorbol-12-myristate	270-290	vasoactive intestinal peptide receptor 1	Homo sapiens	146-151
3495597-1	1987	Membrane-associated interleukin 1 (IL 1) activity was induced on the human macrophage tumor cell line, U937, by pretreatment with phorbol myristic acid (PMA).	phorbol-12-myristate	130-151	interleukin 1 alpha	Homo sapiens	0-39
3495597-1	1987	Membrane-associated interleukin 1 (IL 1) activity was induced on the human macrophage tumor cell line, U937, by pretreatment with phorbol myristic acid (PMA).	phorbol-12-myristate	153-156	interleukin 1 alpha	Homo sapiens	0-39
3011895-5	1986	The binding of 125I-IL 1-beta to VDS-O cells was also inhibited by F(ab)"2 fragments of anti-human IL 1 and recombinant human IL 1-alpha, as well as by unlabeled human IL 1-beta but not by recombinant lymphotoxin, recombinant tumor necrosis factor, or phorbol myristic acid, suggesting that IL 1-alpha and IL 1-beta bind specifically to the same receptor.	phorbol-12-myristate	252-273	interleukin 1 beta	Homo sapiens	20-24
3878830-4	1985	When the effects of various lymphocyte mitogens on CSIF production by these cell lines were examined, it was found that only phorbol myristic acid was stimulatory.	phorbol-12-myristate	125-146	interleukin 10	Homo sapiens	51-55
3864781-7	1985	Phorbol 12-myristate, phorbol 12,13-dibutyrate, and PMA were found to be competitive inhibitors of the beta-alanine-nitrophenyl esterase activity of esterase 1 with Ki values of approximately 7 microM.	phorbol-12-myristate	0-20	carboxylesterase 1C	Mus musculus	149-159
2989297-2	1985	Phorbol 12-myristate, 13-acetate, the calcium ionophore A23187 in the presence or absence of EGTA, and the fluorescent calcium chelator quin-2 also cause an increase in cytoskeletal actin.	phorbol-12-myristate	0-20	actin	Oryctolagus cuniculus	182-187
2989297-3	1985	The stimulated increases in the cytoskeletal actin are not dependent on a rise in the intracellular concentration of free calcium and are not mediated by an increase in the intracellular pH or activation of protein kinase C. The increases in the cytoskeletal actin produced by fMet-Leu-Phe and leukotriene B4, but not by phorbol 12-myristate, 13-acetate, are inhibited by high osmolarity.	phorbol-12-myristate	321-341	actin	Oryctolagus cuniculus	45-50
2989297-3	1985	The stimulated increases in the cytoskeletal actin are not dependent on a rise in the intracellular concentration of free calcium and are not mediated by an increase in the intracellular pH or activation of protein kinase C. The increases in the cytoskeletal actin produced by fMet-Leu-Phe and leukotriene B4, but not by phorbol 12-myristate, 13-acetate, are inhibited by high osmolarity.	phorbol-12-myristate	321-341	actin	Oryctolagus cuniculus	259-264
2981161-10	1985	Peroxide production after stimulation with phorbol myristic acid could be induced by LK, LK with anti-IFN-gamma antibody, 5637, and SK-HEP treatment.	phorbol-12-myristate	43-64	interferon gamma	Homo sapiens	102-111
3878830-5	1985	Further studies demonstrated that optimal CSIF production by the phorbol myristic acid-stimulated leukemic T-lymphocytes could be achieved in a chemically defined, serum-free medium.	phorbol-12-myristate	65-86	interleukin 10	Homo sapiens	42-46
31807355-3	2019	RGE effectively suppressed the monocyte-to-macrophage differentiation induced by phorbol 12-myristate 13-acetated (PMA) by inhibiting the THP-1 cell adhesion.	phorbol-12-myristate	81-113	GLI family zinc finger 2	Homo sapiens	138-143
31807355-3	2019	RGE effectively suppressed the monocyte-to-macrophage differentiation induced by phorbol 12-myristate 13-acetated (PMA) by inhibiting the THP-1 cell adhesion.	phorbol-12-myristate	115-118	GLI family zinc finger 2	Homo sapiens	138-143