PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34575568-3	2021	In this study, we evaluated the effects of Tween 80 and EL-35 on CYP2C8 in vitro and further investigated their impacts on the PK of paclitaxel (PTX) in rats after single or multiple doses.	el-35	56-61	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	65-71
34575568-4	2021	The in vitro study indicated that Tween 80 and EL-35 inhibited CYP2C8 activity in human and rat liver microsomes.	el-35	47-52	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	63-69
34575568-5	2021	EL-35 also decreased the expression of CYP2C8 in HepG2 cells.	el-35	0-5	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	39-45
34575568-7	2021	Further analysis indicated that multiple-dose EL-35 reduced the expression of Cyp2c22 and production of 6-OH-PTX in the rat liver.	el-35	46-51	cytochrome P450, family 2, subfamily c, polypeptide 22	Rattus norvegicus	78-85
34575568-8	2021	Our study suggested that short-term exposure to both PEs did not affect the PK of PTX in rats, but multiple doses of EL-35 increased the AUC and MRT of PTX by downregulating the hepatic expression of Cyp2c22.	el-35	117-122	cytochrome P450, family 2, subfamily c, polypeptide 22	Rattus norvegicus	200-207