PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18024719-8	2008	These results show that despite the compensatory increase in alpha- and gamma-ENaC protein expression observed in mutant mouse lung, low expression of beta-ENaC results in a moderate impairment of baseline AFC and in decreased AFC sensitivity to amiloride, suggesting a possible change in the stoichiometry of ENaC channels.	Amiloride	246-255	sodium channel, nonvoltage-gated 1 beta	Mus musculus	151-160
18171999-5	2008	Li activated only from the basolateral side where its effect was inhibited by amiloride, presumably because Li entered the cells through a basolateral Na-H exchanger.	Amiloride	78-87	solute carrier family 9 member A1	Canis lupus familiaris	151-165
17977920-0	2008	Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC alpha-subunit in mice.	Amiloride	0-9	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	82-86
18288363-2	2008	The freshly isolated airway epithelial tissue displayed a transepithelial basal current of (94.9+-8.2) muA/cm(2), 16.6% and 62.7% of which was inhibited by amiloride (epithelial Na(+) channel blocker, 100 mumol/L) and NPPB (cystic fibrosis transmembrane conductance regulator Cl(-) channel blocker, 100 mumol/L).	Amiloride	156-165	natriuretic peptide B	Homo sapiens	218-222
18288363-2	2008	The freshly isolated airway epithelial tissue displayed a transepithelial basal current of (94.9+-8.2) muA/cm(2), 16.6% and 62.7% of which was inhibited by amiloride (epithelial Na(+) channel blocker, 100 mumol/L) and NPPB (cystic fibrosis transmembrane conductance regulator Cl(-) channel blocker, 100 mumol/L).	Amiloride	156-165	CF transmembrane conductance regulator	Homo sapiens	224-275
18250276-0	2008	Letter regarding article by Hood et al, "The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio".	Amiloride	61-70	renin	Homo sapiens	152-157
18250276-0	2008	Letter regarding article by Hood et al, "The Spironolactone, Amiloride, Losartan, and Thiazide (SALT) double-blind crossover trial in patients with low-renin hypertension and elevated aldosterone-renin ratio".	Amiloride	61-70	renin	Homo sapiens	196-201
17943310-4	2008	After the use of the amiloride derivative HOE-694 at 25 microM, which inhibits the isoforms NHE1 and NHE2, there remained 43% of the above transport rate, the nature of which was investigated.	Amiloride	21-30	solute carrier family 9 member A1	Homo sapiens	92-96
17943310-4	2008	After the use of the amiloride derivative HOE-694 at 25 microM, which inhibits the isoforms NHE1 and NHE2, there remained 43% of the above transport rate, the nature of which was investigated.	Amiloride	21-30	solute carrier family 9 member A2	Homo sapiens	101-105
18054963-2	2008	However, pharmacological properties of ASIC2 homomers including the mechanism of inhibition by amiloride remain unclear.	Amiloride	95-104	acid sensing ion channel subunit 2	Homo sapiens	39-44
18077606-9	2008	Disruption of the NBCn1 gene resulted in reduced NBCn1 expression, and in bladder smooth muscle cells, reduced amiloride-insensitive Na(+)-dependent HCO(3)(-) influx was observed.	Amiloride	111-120	solute carrier family 4, sodium bicarbonate cotransporter, member 7	Mus musculus	18-23
17977920-2	2008	ENaC activity is blocked by amiloride, which in several mammalian species also inhibits taste responses to NaCl.	Amiloride	28-37	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	0-4
17977920-10	2008	This suggests that the R616W variation in the alphaENaC subunit affects amiloride sensitivity of the ENaC channel and provides evidence that ENaC is involved in amiloride-sensitive salt taste responses in mice.	Amiloride	72-81	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	51-55
17977920-10	2008	This suggests that the R616W variation in the alphaENaC subunit affects amiloride sensitivity of the ENaC channel and provides evidence that ENaC is involved in amiloride-sensitive salt taste responses in mice.	Amiloride	72-81	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	101-105
17977920-10	2008	This suggests that the R616W variation in the alphaENaC subunit affects amiloride sensitivity of the ENaC channel and provides evidence that ENaC is involved in amiloride-sensitive salt taste responses in mice.	Amiloride	161-170	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	51-55
17977920-10	2008	This suggests that the R616W variation in the alphaENaC subunit affects amiloride sensitivity of the ENaC channel and provides evidence that ENaC is involved in amiloride-sensitive salt taste responses in mice.	Amiloride	161-170	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	101-105
17849171-8	2008	In the presence of these membrane transport inhibitors, ACh still evoked a decrease in [Mg(2+)](i) but the response was less pronounced with either [Na(+)](o) removal or in the presence of either amiloride or quinidine.	Amiloride	196-205	acyl-CoA thioesterase 12	Rattus norvegicus	56-59
18568693-0	2008	Regulation of blood pressure, natriuresis and renal thiazide/amiloride sensitivity in PPARalpha null mice.	Amiloride	61-70	peroxisome proliferator activated receptor alpha	Mus musculus	86-95
18568693-11	2008	These data suggest that PPARalpha participates in pressure natriuresis and affects Na transport via amiloride- and thiazide-sensitive mechanisms.	Amiloride	100-109	peroxisome proliferator activated receptor alpha	Mus musculus	24-33
18977715-3	2008	ENaC is a channel that mediates entry of Na+ from the luminal fluid into the cells in many reabsorbing epithelia; it is aldosterone, vasopressin, insulin and catecholamine-inducible, modulated by estrogens and progesterone and blocked by amiloride and its analogs.	Amiloride	238-247	arginine vasopressin	Homo sapiens	133-144
17913870-7	2007	These effects were blocked by amiloride 500 microM (a nonspecific NHE blocker) and HOE694 100 microM (NHE blocker with NHE1 and 2 isoform selectivity).	Amiloride	30-39	solute carrier family 9 member C1	Homo sapiens	66-69
17939964-5	2008	Urokinase plasminogen activator (uPA) was constitutively expressed on neuronal membrane fractions, and amiloride (an antagonist of uPA) or plasminogen activator inhibitor (PAI)-1 significantly reduced IL-1beta-induced neurotoxicity.	Amiloride	103-112	plasminogen activator, urokinase	Rattus norvegicus	0-31
17939964-5	2008	Urokinase plasminogen activator (uPA) was constitutively expressed on neuronal membrane fractions, and amiloride (an antagonist of uPA) or plasminogen activator inhibitor (PAI)-1 significantly reduced IL-1beta-induced neurotoxicity.	Amiloride	103-112	plasminogen activator, urokinase	Rattus norvegicus	131-134
17939964-5	2008	Urokinase plasminogen activator (uPA) was constitutively expressed on neuronal membrane fractions, and amiloride (an antagonist of uPA) or plasminogen activator inhibitor (PAI)-1 significantly reduced IL-1beta-induced neurotoxicity.	Amiloride	103-112	interleukin 1 beta	Rattus norvegicus	201-209
19008962-5	2008	The ligand-independent route is amiloride-sensitive, does not require uPAR partitioning into lipid rafts, is independent of the activity of small GTPases RhoA, Rac1 and Cdc42, and does not require PI3K activity.	Amiloride	32-41	cell division cycle 42	Homo sapiens	169-174
17940289-9	2007	Overexpression of epsin reduced amiloride-sensitive current in CCD cells.	Amiloride	32-41	serine (or cysteine) peptidase inhibitor, clade A, member 1F	Mus musculus	18-23
21180133-0	2007	[Amiloride attenuates hypoxia-induced proliferation of rats pulmonary artery smooth muscle cells by suppressing Na+/ H+ exchanger-1].	Amiloride	1-10	solute carrier family 9 member A1	Rattus norvegicus	112-132
17878160-9	2007	Transfection of Hsc70 siRNA inhibited the constitutively activated amiloride-sensitive current, decreased migration, and increased ASIC2 surface expression in glioma cells.	Amiloride	67-76	heat shock protein family A (Hsp70) member 8	Homo sapiens	16-21
17717051-5	2007	The cellular uptake of Pax4 PTD can be completely blocked by heparin, whereas cytochalasin D and amiloride were partially effective in blocking the Pax4 protein entry.	Amiloride	97-106	paired box 4	Homo sapiens	148-152
17606467-8	2007	This hypothesis is supported by the fact that dNKAIN, but not NKAIN1, induces voltage-independent amiloride-insensitive Na(+)-specific conductance that can be blocked by lanthanum.	Amiloride	98-107	Na,K-ATPase Interacting	Drosophila melanogaster	46-52
21180133-3	2007	RESULTS: Hypoxic exposure heightened intracellular pH and mRNA expression of NHE-1 in PASMCs, however, 3.123-50 micromol/L amiloride depressed them gradually.	Amiloride	123-132	solute carrier family 9 member A1	Rattus norvegicus	77-82
21180133-5	2007	CONCLUSION: Na+/H+ exchange inhibitor amiloride can suppress hypoxia-induced proliferation in pulmonary artery smooth muscle cells, which is due to depress activity and expression of NHE-1.	Amiloride	38-47	solute carrier family 9 member A1	Rattus norvegicus	183-188
17556672-9	2007	When mTOR was inhibited (3 nM rapamycin) there was reduced 4E-BP phosphorylation, fewer ribosomes on alpha-ENaC mRNA, and decreased amiloride-sensitive short-circuit current, but no change in ribosomal loading onto any of beta- or gamma-ENaC or cytokeratin 18 mRNAs.	Amiloride	132-141	mechanistic target of rapamycin kinase	Homo sapiens	5-9
17652085-0	2007	(NDRG2) stimulates amiloride-sensitive Na+ currents in Xenopus laevis oocytes and fisher rat thyroid cells.	Amiloride	19-28	NDRG family member 2	Homo sapiens	1-6
17652085-4	2007	To test this hypothesis we measured the amiloride-sensitive (2 microm) whole cell current (DeltaI(ami)) in Xenopus laevis oocytes expressing ENaC alone or co-expressing ENaC and NDRG2.	Amiloride	40-49	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	141-145
17652085-4	2007	To test this hypothesis we measured the amiloride-sensitive (2 microm) whole cell current (DeltaI(ami)) in Xenopus laevis oocytes expressing ENaC alone or co-expressing ENaC and NDRG2.	Amiloride	40-49	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	169-173
17652085-4	2007	To test this hypothesis we measured the amiloride-sensitive (2 microm) whole cell current (DeltaI(ami)) in Xenopus laevis oocytes expressing ENaC alone or co-expressing ENaC and NDRG2.	Amiloride	40-49	NDRG family member 2	Homo sapiens	178-183
17609287-7	2007	Induction of MLPH in these cells led to a relatively modest, but statistically significant, increase in amiloride-sensitive Na+ current, suggesting the MLPH may be involved in ENaC trafficking.	Amiloride	104-113	melanophilin	Mus musculus	13-17
17609287-7	2007	Induction of MLPH in these cells led to a relatively modest, but statistically significant, increase in amiloride-sensitive Na+ current, suggesting the MLPH may be involved in ENaC trafficking.	Amiloride	104-113	melanophilin	Mus musculus	152-156
17609287-7	2007	Induction of MLPH in these cells led to a relatively modest, but statistically significant, increase in amiloride-sensitive Na+ current, suggesting the MLPH may be involved in ENaC trafficking.	Amiloride	104-113	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	176-180
17613525-1	2007	Amiloride-sensitive ion channels are formed from homo- or heteromeric combinations of subunits from the epithelial Na+ channel (ENaC)/degenerin superfamily, which also includes the acid-sensitive ion channel (ASIC) family.	Amiloride	0-9	acid sensing ion channel subunit 1	Homo sapiens	181-207
17613525-1	2007	Amiloride-sensitive ion channels are formed from homo- or heteromeric combinations of subunits from the epithelial Na+ channel (ENaC)/degenerin superfamily, which also includes the acid-sensitive ion channel (ASIC) family.	Amiloride	0-9	acid sensing ion channel subunit 1	Homo sapiens	209-213
17613525-5	2007	The results of this study suggest that heteromeric complexes of ASIC and ENaC subunits may underlie the diversity of amiloride-sensitive cation conductances observed in a wide variety of tissues and cell types where co-expression of ASIC and ENaC subunits has been observed.	Amiloride	117-126	acid sensing ion channel subunit 1	Homo sapiens	64-68
17613525-5	2007	The results of this study suggest that heteromeric complexes of ASIC and ENaC subunits may underlie the diversity of amiloride-sensitive cation conductances observed in a wide variety of tissues and cell types where co-expression of ASIC and ENaC subunits has been observed.	Amiloride	117-126	acid sensing ion channel subunit 1	Homo sapiens	233-237
17663006-3	2007	The rank order for inhibition of NHE activity in acid-loaded T84 cells was 5-(N-ethyl-N-isopropyl)-amiloride (EIPA; IC(50)=519 [465, 579] nM)>cariporide (IC(50)=630 [484, 819] nM)>amiloride (IC(50)=19 [16, 24] microM); the NHE3 inhibitor S3226 was found to be devoid of effect.	Amiloride	99-108	solute carrier family 9 member C1	Homo sapiens	33-36
17431790-0	2007	Acute acidification or amiloride treatment suppresses the ability of Hsp70 to inhibit heat-induced apoptosis.	Amiloride	23-32	heat shock protein family A (Hsp70) member 4	Homo sapiens	69-74
17603555-7	2007	KEY RESULTS: Phenformin, AICAR and metformin increased AMPK (alpha1) activity and decreased I(amiloride).	Amiloride	94-103	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	25-30
17431747-9	2007	The mutant form of the NHE1 protein could be distinguished from the endogenous Na(+)/H(+) exchanger by its resistance to inhibition by amiloride analogs.	Amiloride	135-144	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	23-27
17244820-7	2007	However, oocytes coexpressing AKAP15 exhibited an 80% and 91% reduction in the amiloride-sensitive, whole-cell conductance in high and low Na+ conditions, respectively.	Amiloride	79-88	A-kinase anchoring protein 7 L homeolog	Xenopus laevis	30-36
19093442-0	2007	Amiloride inhibition of vacuolar Na+/H+ antiporter enhance salt stress in Zea mays L. seedlings.	Amiloride	0-9	sodium/hydrogen exchanger 2-like	Zea mays	33-50
17493937-0	2007	NHE1 inhibition by amiloride- and benzoylguanidine-type compounds.	Amiloride	19-28	solute carrier family 9 member A1	Homo sapiens	0-4
17493937-2	2007	The interaction of the ubiquitous Na(+)/H(+) exchanger, NHE1, with its commonly used inhibitors, amiloride- and benzoylguanidine (Hoechst type inhibitor (HOE))-type compounds, is incompletely understood.	Amiloride	97-106	solute carrier family 9 member A1	Homo sapiens	56-60
17493937-5	2007	Here we generated chimeras to "knock in" amiloride and HOE sensitivity to PaNHE1, and we thereby identified several NHE1 regions involved in inhibitor interaction.	Amiloride	41-50	solute carrier family 9 member A1	Homo sapiens	76-80
17493937-10	2007	Replacing an LFFFY motif in TM region 4 of PaNHE1 with the corresponding residues of hNHE1 (VFFLF) or AtNHE1 (TFFLF) greatly increased sensitivity to both amiloride- and HOE-type compounds, despite the fact that AtNHE1 is HOE694-insensitive.	Amiloride	155-164	solute carrier family 9 member A1	Homo sapiens	85-90
17552965-9	2007	After in vitro incubation with amiloride (100 mm) there was less NHE1 expression associated with reduced 32 kDa pro-caspase-3 protein levels.	Amiloride	31-40	solute carrier family 9 member A1	Rattus norvegicus	65-69
17552965-9	2007	After in vitro incubation with amiloride (100 mm) there was less NHE1 expression associated with reduced 32 kDa pro-caspase-3 protein levels.	Amiloride	31-40	caspase 3	Rattus norvegicus	116-125
19093442-7	2007	Malondialdehyde content and the activity of antioxidant enzymes such as guaiacol peroxidase, ascorbate peroxidase and catalase were increased in salt stressed plants specially in plants treated with salt and amiloride.	Amiloride	208-217	peroxidase 1	Zea mays	81-91
19093442-7	2007	Malondialdehyde content and the activity of antioxidant enzymes such as guaiacol peroxidase, ascorbate peroxidase and catalase were increased in salt stressed plants specially in plants treated with salt and amiloride.	Amiloride	208-217	peroxidase 1	Zea mays	103-113
19093442-8	2007	Therefore salt stress has caused osmotic and oxidative stress in plants and amiloride as inhibitor of vacuolar Na+/H+ antiporter has been increased salt stress.	Amiloride	76-85	sodium/hydrogen exchanger 2-like	Zea mays	111-128
17311909-10	2007	Chronic furosemide +/- amiloride administration induced a translocation of pendrin to the apical membrane, while total protein abundance was not increased.	Amiloride	23-32	solute carrier family 26 member 4	Rattus norvegicus	75-82
17651644-12	2007	CONCLUSION: Administration of u-PA inhibitor-amiloride significantly alleviated airway inflammation and the pathological changes in COPD rats, suggesting that the u-PA system components are key mediators regulating the inflammatory reaction and tissue remodeling in the pathological process of COPD.	Amiloride	45-54	plasminogen activator, urokinase	Rattus norvegicus	30-34
17651644-12	2007	CONCLUSION: Administration of u-PA inhibitor-amiloride significantly alleviated airway inflammation and the pathological changes in COPD rats, suggesting that the u-PA system components are key mediators regulating the inflammatory reaction and tissue remodeling in the pathological process of COPD.	Amiloride	45-54	plasminogen activator, urokinase	Rattus norvegicus	163-167
17200158-1	2007	The expression and activity of epithelial Na(+) channels (ENaC) in the medullary collecting duct of the rat kidney were examined using a combination of whole cell patch-clamp measurements of amiloride-sensitive currents (I(Na)) in split-open tubules and Western blot analysis of alpha-, beta-, and gamma-ENaC proteins.	Amiloride	191-200	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	31-56
17200158-1	2007	The expression and activity of epithelial Na(+) channels (ENaC) in the medullary collecting duct of the rat kidney were examined using a combination of whole cell patch-clamp measurements of amiloride-sensitive currents (I(Na)) in split-open tubules and Western blot analysis of alpha-, beta-, and gamma-ENaC proteins.	Amiloride	191-200	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	58-62
17192275-7	2007	Bioelectric measurements of NBC1-/- colons revealed increased amiloride-sensitive Na+ absorption.	Amiloride	62-71	solute carrier family 4 (anion exchanger), member 4	Mus musculus	28-32
16884771-6	2007	Treatment of K562 cells either with amiloride (an inhibitor of NHE1) or with 5-(N-ethyl-N-isopropyl)-amiloride (EIPA, a selective inhibitor of NHE1) resulted in significant decrease of VEGF mRNA and VEGF protein levels.	Amiloride	36-45	solute carrier family 9 member A1	Homo sapiens	63-67
16884771-6	2007	Treatment of K562 cells either with amiloride (an inhibitor of NHE1) or with 5-(N-ethyl-N-isopropyl)-amiloride (EIPA, a selective inhibitor of NHE1) resulted in significant decrease of VEGF mRNA and VEGF protein levels.	Amiloride	36-45	vascular endothelial growth factor A	Homo sapiens	185-189
16884771-6	2007	Treatment of K562 cells either with amiloride (an inhibitor of NHE1) or with 5-(N-ethyl-N-isopropyl)-amiloride (EIPA, a selective inhibitor of NHE1) resulted in significant decrease of VEGF mRNA and VEGF protein levels.	Amiloride	36-45	vascular endothelial growth factor A	Homo sapiens	199-203
17157922-6	2007	The pH recovery phenomenon was mediated by an amiloride-sensitive Na+/H+ exchanger and H+ channel, and was inhibited by UO126 (an ERK1/2 MAPK phosphorylation inhibitor), Go6850 (a PKC inhibitor) and calcium chelating.	Amiloride	46-55	mitogen-activated protein kinase 3	Bos taurus	130-136
17382185-2	2007	METHODS: Cystometry with continuous infusion was performed to investigate the effect of intravesically perfused amiloride (a blocker of ENaC) on micturition reflex in urethane-anesthetized female rats.	Amiloride	112-121	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	136-140
17198922-3	2007	In addition, higher doses of amiloride were found to be capable of inhibiting the Na(+)/H(+) exchangers (NHE) and the Na(+)/Ca(2+) exchangers.	Amiloride	29-38	solute carrier family 9 member C1	Homo sapiens	105-108
17198922-4	2007	In time, several amiloride analogs have been synthesized to have a marked increase in their specificity to inhibit the ENaC, the NHE or the Na(+)/Ca(2+) exchangers.	Amiloride	17-26	solute carrier family 9 member C1	Homo sapiens	129-132
17190903-6	2007	Using these discriminative tools, we showed that NaN/Nav1.9, Cav3.2, and amiloride- and Ni(2+)-resistant I(Ca)T (AR-I(Ca)T) contribute differentially to LVA currents in distinct sensory cell populations.	Amiloride	73-82	catalase	Homo sapiens	113-122
16644043-8	2007	Amiloride, a sodium-hydrogen-exchange inhibitor, inhibited two thirds of the PIE of ET-1 in failing myocytes.	Amiloride	0-9	endothelin 1	Homo sapiens	84-88
17210677-7	2007	EMMPRIN-expressing cells also exhibited enhanced invasive potential in vitro, and the use of amiloride (uPA inhibitor) and marimastat (MMP inhibitor) showed that the two proteolytic systems reduced alone and in combination the invasive potential mediated through EMMPRIN.	Amiloride	93-102	plasminogen activator, urokinase	Homo sapiens	104-107
17088900-6	2006	However, TIL did express high levels of urokinase-type plasminogen activator receptor (uPAR) and inhibitory antibodies and amiloride both significantly inhibited TIL adhesion to vitronectin and reduced transendothelial migration of lymphocytes across liver endothelium in vitro.	Amiloride	123-132	vitronectin	Homo sapiens	178-189
17287577-8	2006	The amiloride-sensitivity of ASIC2a/ ASIC2b heteromer lessened with decreasing pH and almost completely disappeared at pH 2.0.	Amiloride	4-13	acid sensing ion channel subunit 2	Rattus norvegicus	29-34
16891388-6	2006	Glibenclamide and clofilium (K(ATP) and KvLQT1 inhibitors) strongly reduced basal transepithelial current, amiloride-sensitive Na(+) current, and forskolin-activated Cl(-) currents, whereas pinacidil, a K(ATP) activator, increased them.	Amiloride	107-116	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	40-46
17082882-4	2006	In a docking approach with monomeric, pentameric and hexameric bundle models of Vpu corresponding to the transmembrane part of the protein, a putative binding site of hexamethylene amiloride is proposed and is compared with the site for the nonpotent amiloride.	Amiloride	181-190	Vpu	Human immunodeficiency virus 1	80-83
16923776-3	2006	The amiloride-insensitive mechanism, which predominates in circumvallate and foliate taste buds, was recently reported to involve a variant of the nonselective cation channel TRPV1.	Amiloride	4-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	175-180
17200691-7	2006	The coiled-coiled domain H3 (194-266) of syntaxin1A inhibited, however the inclusion of the transmembrane domain to this motif (194-288) augmented amiloride sensitive currents.	Amiloride	147-156	syntaxin 1A	Homo sapiens	41-51
17108132-4	2006	Treatment of 2008 cells with DDP in combination with inhibitors of various endosomal pathways (amiloride, cytochalasin D, nystatin, and methyl-beta-cyclodextrin) showed that hCTR1 degradation was blocked by amiloride and cytochalasin D, indicating that hCTR1 was internalized primarily by macropinocytosis.	Amiloride	95-104	solute carrier family 31 member 1	Homo sapiens	174-179
17108132-4	2006	Treatment of 2008 cells with DDP in combination with inhibitors of various endosomal pathways (amiloride, cytochalasin D, nystatin, and methyl-beta-cyclodextrin) showed that hCTR1 degradation was blocked by amiloride and cytochalasin D, indicating that hCTR1 was internalized primarily by macropinocytosis.	Amiloride	207-216	solute carrier family 31 member 1	Homo sapiens	174-179
17108132-4	2006	Treatment of 2008 cells with DDP in combination with inhibitors of various endosomal pathways (amiloride, cytochalasin D, nystatin, and methyl-beta-cyclodextrin) showed that hCTR1 degradation was blocked by amiloride and cytochalasin D, indicating that hCTR1 was internalized primarily by macropinocytosis.	Amiloride	207-216	solute carrier family 31 member 1	Homo sapiens	253-258
16923776-5	2006	Surprisingly, TRPV1 knockout mice not only detected NaCl in the presence of amiloride but they preferred NaCl over water at concentrations avoided by the wild-type mice.	Amiloride	76-85	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	14-19
16923776-9	2006	Analyses of consumption data also revealed that TRPV1 knockout mice ingested more of the NaCl, with and without amiloride, and KCl solutions than the wild-type mice.	Amiloride	112-121	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	48-53
16985514-6	2006	This effect of furosemide was abolished with amiloride or benzamil blocking ENaC action.	Amiloride	45-54	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	76-80
16769263-12	2006	The ASIC blocker amiloride inhibited acid-induced c-Fos expression in F-11 cells.	Amiloride	17-26	acid-sensing (proton-gated) ion channel 1	Mus musculus	4-8
16769263-12	2006	The ASIC blocker amiloride inhibited acid-induced c-Fos expression in F-11 cells.	Amiloride	17-26	FBJ osteosarcoma oncogene	Mus musculus	50-55
16897044-2	2006	Moreover, the amiloride-sensitive transepithelial potential difference in the collecting duct is lower in gene-targeted mice lacking SGK1 (sgk1 (-/-)) than in their wild-type littermates (sgk1 (+/+)).	Amiloride	14-23	serum/glucocorticoid regulated kinase 1	Mus musculus	133-137
16714334-6	2006	The decrease in resistance was accompanied by an increase in mannitol flux across the epithelium and occurred in cystic fibrosis transmembrane conductance receptor (CFTR) epithelium pretreated with amiloride to block Na and Cl conductances, confirming that the decrease in resistance represented an increase in paracellular conductance.	Amiloride	198-207	CF transmembrane conductance regulator	Homo sapiens	113-163
16714334-6	2006	The decrease in resistance was accompanied by an increase in mannitol flux across the epithelium and occurred in cystic fibrosis transmembrane conductance receptor (CFTR) epithelium pretreated with amiloride to block Na and Cl conductances, confirming that the decrease in resistance represented an increase in paracellular conductance.	Amiloride	198-207	CF transmembrane conductance regulator	Homo sapiens	165-169
16897044-2	2006	Moreover, the amiloride-sensitive transepithelial potential difference in the collecting duct is lower in gene-targeted mice lacking SGK1 (sgk1 (-/-)) than in their wild-type littermates (sgk1 (+/+)).	Amiloride	14-23	serum/glucocorticoid regulated kinase 1	Mus musculus	139-143
16897044-2	2006	Moreover, the amiloride-sensitive transepithelial potential difference in the collecting duct is lower in gene-targeted mice lacking SGK1 (sgk1 (-/-)) than in their wild-type littermates (sgk1 (+/+)).	Amiloride	14-23	serum/glucocorticoid regulated kinase 1	Mus musculus	188-192
16873722-8	2006	Surprisingly, amiloride, which blocks ASICs when they are activated at lower pH, increases ASIC3 current evoked at pH 7.0.	Amiloride	14-23	acid sensing ion channel subunit 3	Rattus norvegicus	91-96
16895983-3	2006	Treatment of nude mice containing PNEC tumor xenografts with (i) amiloride, a diuretic that inhibits Abp1, an enzyme involved in NE cell GABA metabolism, (ii) carbidopa, an inhibitor of dopa decarboxylase which functions upstream of Abp1, plus (iii) flumazenil, a benzodiazepine antagonist that binds to GABA(A) receptors, leads to significant reductions in tumor growth.	Amiloride	65-74	amine oxidase, copper-containing 1	Mus musculus	101-105
17172009-8	2006	Na+/Mg2+ antiport is inhibited by amiloride, quinidine and imipramine.	Amiloride	34-43	mucin 7, secreted	Homo sapiens	4-7
17172009-13	2006	Na+-independent Mg2+ efflux via the choline exchanger is also inhibited by amiloride, quinidine and imipramine, and can also be regulated by phosphorylation-dephosphorylation.	Amiloride	75-84	mucin 7, secreted	Homo sapiens	16-19
16477455-2	2006	Activation of the CNP/NPR-B pathway in pulmonary epithelium has been linked to the inhibition of amiloride-sensitive sodium absorption and to the stimulation of the cystic fibrosis transmembrane conductance regulator (CFTR).	Amiloride	97-106	C-type natriuretic peptide	Ovis aries	18-21
16691295-4	2006	Hypertensive Cyp4a10-/- mice had a dysfunctional kidney epithelial sodium channel and became normotensive when administered amiloride, a selective inhibitor of this sodium channel.	Amiloride	124-133	cytochrome P450, family 4, subfamily a, polypeptide 10	Mus musculus	13-20
16864689-5	2006	Interestingly, several members of the solute carrier family of amino acid transporter (Slc7a1, Slc7a3, Slc6a9, and tumor-associated protein 1) genes involved in amino acid synthesis (Phgdh, Psat1, Psph, Cars, and Asns), as well as the amiloride-sensitive epithelial sodium channel gene (Scnn1a) were up-regulated by the application of force.	Amiloride	235-244	solute carrier family 7 member 1	Rattus norvegicus	87-93
16864689-5	2006	Interestingly, several members of the solute carrier family of amino acid transporter (Slc7a1, Slc7a3, Slc6a9, and tumor-associated protein 1) genes involved in amino acid synthesis (Phgdh, Psat1, Psph, Cars, and Asns), as well as the amiloride-sensitive epithelial sodium channel gene (Scnn1a) were up-regulated by the application of force.	Amiloride	235-244	solute carrier family 7 member 3	Rattus norvegicus	95-101
16864689-5	2006	Interestingly, several members of the solute carrier family of amino acid transporter (Slc7a1, Slc7a3, Slc6a9, and tumor-associated protein 1) genes involved in amino acid synthesis (Phgdh, Psat1, Psph, Cars, and Asns), as well as the amiloride-sensitive epithelial sodium channel gene (Scnn1a) were up-regulated by the application of force.	Amiloride	235-244	solute carrier family 6 member 9	Rattus norvegicus	103-109
16864689-5	2006	Interestingly, several members of the solute carrier family of amino acid transporter (Slc7a1, Slc7a3, Slc6a9, and tumor-associated protein 1) genes involved in amino acid synthesis (Phgdh, Psat1, Psph, Cars, and Asns), as well as the amiloride-sensitive epithelial sodium channel gene (Scnn1a) were up-regulated by the application of force.	Amiloride	235-244	solute carrier family 7 member 5	Rattus norvegicus	115-141
16864689-5	2006	Interestingly, several members of the solute carrier family of amino acid transporter (Slc7a1, Slc7a3, Slc6a9, and tumor-associated protein 1) genes involved in amino acid synthesis (Phgdh, Psat1, Psph, Cars, and Asns), as well as the amiloride-sensitive epithelial sodium channel gene (Scnn1a) were up-regulated by the application of force.	Amiloride	235-244	phosphoserine aminotransferase 1	Rattus norvegicus	190-195
16704974-0	2006	Surface expression of ASIC2 inhibits the amiloride-sensitive current and migration of glioma cells.	Amiloride	41-50	acid sensing ion channel subunit 2	Homo sapiens	22-27
16611636-7	2006	Inhibition of uPA activity with natural (plasminogen activator inhibitor-1) or synthetic (amiloride) inhibitors diminished HT-hi/diss Matrigel invasion in vitro and intravasation and metastasis in vivo.	Amiloride	90-99	plasminogen activator, urokinase	Homo sapiens	14-17
16630545-1	2006	Liddle"s syndrome (excessive absorption of sodium ions) and PHA-1 (pseudohypoaldosteronism type 1) with decreased sodium absorption are caused by the mutations in the amiloride-sensitive epithelial sodium channel ENaC.	Amiloride	167-176	sodium channel epithelial 1 subunit gamma	Homo sapiens	60-97
16630545-4	2006	We hereby report that Rab27a-dependent inhibition is associated with the GTP/GDP status as constitutively active or GTPase-deficient mutant Q78L inhibits amiloride-sensitive currents whereas GDP-locked inactive mutant T23N showed no effect.	Amiloride	154-163	RAB27A, member RAS oncogene family	Homo sapiens	22-28
16394027-3	2006	N-amidino-3,5-diamino-6-chloropyrazine-carboxamide (amiloride) and 4-[4-(dimethylamino)-styryl]-N-methylpyridinium (ASP) showed concentration-dependent uptake in hOCT2 at 37 degrees C. After subtraction of unspecific uptake determined in WT at 37 degrees C or in hOCT2 at 8 degrees C saturable specific uptake of both substrates was measured.	Amiloride	0-50	solute carrier family 22 member 2	Homo sapiens	162-167
16394027-3	2006	N-amidino-3,5-diamino-6-chloropyrazine-carboxamide (amiloride) and 4-[4-(dimethylamino)-styryl]-N-methylpyridinium (ASP) showed concentration-dependent uptake in hOCT2 at 37 degrees C. After subtraction of unspecific uptake determined in WT at 37 degrees C or in hOCT2 at 8 degrees C saturable specific uptake of both substrates was measured.	Amiloride	0-50	solute carrier family 22 member 2	Homo sapiens	263-268
16394027-4	2006	Km values of hOCT2-mediated uptake of 95 microM amiloride and 24 microM ASP were calculated.	Amiloride	48-57	solute carrier family 22 member 2	Homo sapiens	13-18
16394027-8	2006	The data indicate that saturable transport by hOCT2 can be measured by the fluorescent substrates amiloride and ASP and that transport activity for both substrates is regulated similarly.	Amiloride	98-107	solute carrier family 22 member 2	Homo sapiens	46-51
16951561-1	2006	We investigated whether amiloride-blockable proton-gated cation channels ASIC1a (acid-sensing ion channel-1a) and ASIC1b are expressed in the stereocilia of mouse cochlear hair cells.	Amiloride	24-33	acid-sensing (proton-gated) ion channel 1	Mus musculus	73-79
16581026-5	2006	Recording of amiloride-sensitive currents in both systems suggest that SNAP-23 modulates channel function, though a much higher concentration is required to inhibit ENaC in Xenopus oocytes.	Amiloride	13-22	synaptosome associated protein 23kDa L homeolog	Xenopus laevis	71-78
16581026-6	2006	The introduction of Botulinum toxin A (a neurotoxin which cleaves SNAP-23), but not Botulinum toxin B or heat-inactivated Botulinum toxin A, reversed the inhibitory effect of SNAP-23 on amiloride-sensitive currents.	Amiloride	186-195	synaptosome associated protein 23kDa L homeolog	Xenopus laevis	175-182
16389071-5	2006	Rab4 over-expression inhibited amiloride-sensitive currents.	Amiloride	31-40	RAB4A, member RAS oncogene family	Homo sapiens	0-4
16495435-7	2006	When amiloride (a sodium channel blocker) was added to all solutions to reduce the taste of Na+, discrimination accuracy of both genotypes of mice decreased but more so for the T1R3-KO mice than the WT mice.	Amiloride	5-14	taste receptor, type 1, member 3	Mus musculus	177-181
16585520-4	2006	In Xenopus oocytes, overexpression of human Hsc70 decreased the functional (defined as amiloride-sensitive whole-oocyte current) and surface expression of murine ENaC (mENaC) in a concentration-dependent fashion.	Amiloride	87-96	heat shock protein family A (Hsp70) member 8	Homo sapiens	44-49
16547305-4	2006	The alkalosis-induced p38-MAPK activation depended upon the Na(+)/H(+) exchanger (NHE) and Na(+)/K(+)-ATPase, because it was abolished when the NHE inhibitors amiloride and HOE642 and the Na(+)/K(+)-ATPase inhibitor, ouabain, were used.	Amiloride	159-168	mitogen-activated protein kinase 14	Homo sapiens	22-25
16547305-4	2006	The alkalosis-induced p38-MAPK activation depended upon the Na(+)/H(+) exchanger (NHE) and Na(+)/K(+)-ATPase, because it was abolished when the NHE inhibitors amiloride and HOE642 and the Na(+)/K(+)-ATPase inhibitor, ouabain, were used.	Amiloride	159-168	solute carrier family 9 member C1	Homo sapiens	82-85
16547305-4	2006	The alkalosis-induced p38-MAPK activation depended upon the Na(+)/H(+) exchanger (NHE) and Na(+)/K(+)-ATPase, because it was abolished when the NHE inhibitors amiloride and HOE642 and the Na(+)/K(+)-ATPase inhibitor, ouabain, were used.	Amiloride	159-168	solute carrier family 9 member C1	Homo sapiens	144-147
16482102-8	2006	HRP flux was substantially higher in FAE than in VE, and was reduced by an amiloride analog.	Amiloride	75-84	ELOVL fatty acid elongase 6	Homo sapiens	37-40
16207792-10	2006	Amiloride, ENaC-selective amiloride analogs (benzamil and phenamil), and protease inhibitors (aprotinin and leupeptin) attenuated heightened V(te) and I(sc).	Amiloride	26-35	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	11-15
16580864-10	2006	Amiloride (1 mM) inhibited I(NH4), DeltapHi and dpHi/dt in oocytes expressing Rhbg but not in control oocytes.	Amiloride	0-9	Rh family B glycoprotein L homeolog	Xenopus laevis	78-82
16613790-8	2006	NHE activity was determined according to Orlov"s method as amiloride-sensitive H(+) efflux from acid-loaded cells.	Amiloride	59-68	solute carrier family 9 member C1	Homo sapiens	0-3
16636720-13	2006	Inhibition of urokinase-type plasminogen activator and modulation of field strengths by amiloride seem to be responsible for this effect.	Amiloride	88-97	plasminogen activator, urokinase	Homo sapiens	14-50
16226002-14	2006	In the present study, we have demonstrated an enhanced amiloride-sensitive Isc and fluid absorption in NHMEE cells, where the role of CFTR is limited.	Amiloride	55-64	CF transmembrane conductance regulator	Homo sapiens	134-138
16259948-4	2005	Pre-incubation with amiloride enhanced GCAP2-activated retGC activity in a manner similar to that by ATP pre-binding; however, amiloride did not directly stimulate the retGC activity.	Amiloride	20-29	guanylate cyclase activator 1B	Homo sapiens	39-44
16317039-11	2006	These compounds, as well as amiloride, inhibited trk1,2 growth and thereby improved the efficacy of this yeast mutant as a heterologous expression system for CNGCs.	Amiloride	28-37	Trk1p	Saccharomyces cerevisiae S288C	49-53
16685601-4	2006	In cultured mouse cortical neurons, lowering extracellular pH to the level commonly seen in ischemic brain activates amiloride-sensitive ASIC currents.	Amiloride	117-126	acid-sensing (proton-gated) ion channel 1	Mus musculus	137-141
15972390-3	2005	AVP (10(-9) M) stimulated both the amiloride-sensitive transepithelial Na(+) transport measured in intact cells and the maximal Na pump current measured by the ouabain-sensitive short-circuit current in apically permeabilized cells.	Amiloride	35-44	arginine vasopressin	Homo sapiens	0-3
16336655-1	2005	BACKGROUND: Amiloride derivatives, commonly used for their diuretic and antihypertensive properties, can also cause a sustained but reversible decrease of intracellular pH (pHi).	Amiloride	12-21	glucose-6-phosphate isomerase 1	Mus musculus	173-176
16236259-9	2005	Alternatively, introduction of isoform-specific small inhibitory RNA (SiRNA) reversed the Rab-dependent inhibition of amiloride-sensitive currents.	Amiloride	118-127	RAB27A, member RAS oncogene family	Homo sapiens	90-93
16259948-4	2005	Pre-incubation with amiloride enhanced GCAP2-activated retGC activity in a manner similar to that by ATP pre-binding; however, amiloride did not directly stimulate the retGC activity.	Amiloride	20-29	guanylate cyclase 2D, retinal	Homo sapiens	55-60
16059913-0	2005	Role of HER-2/neu signaling in sensitivity to tumor necrosis factor-related apoptosis-inducing ligand: enhancement of TRAIL-mediated apoptosis by amiloride.	Amiloride	146-155	TNF superfamily member 10	Homo sapiens	46-101
16267030-5	2005	Experiments with amiloride, which inhibits endocytosis, and N-acetyl-l-leucinyl-l-norleucinal, a proteasome inhibitor, confirmed that PTD-NY-ESO-1 entered dendritic cells by protein transduction and was degraded by the proteasome.	Amiloride	17-26	cancer/testis antigen 1A	Homo sapiens	138-146
16563257-17	2005	Amiloride, a NHE-1 inhibitor, may relieve this vessel stenosis.	Amiloride	0-9	sodium/hydrogen exchanger 1	Oryctolagus cuniculus	13-18
15914781-5	2005	Then, we determined pressure- and agonist-induced constriction and changes in vascular smooth muscle cytosolic Ca(2+) and Na(+) in isolated mouse renal interlobar arteries following DEG/ENaC inhibition with amiloride and benzamil.	Amiloride	207-216	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	186-190
15914781-8	2005	Selective DEG/ENaC inhibition, with low doses of amiloride and benzamil, abolishes pressure-induced constriction and increases in cytosolic Ca(2+) and Na(+) without diminishing agonist-induced responses in isolated mouse interlobar arteries.	Amiloride	49-58	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	14-18
16059913-0	2005	Role of HER-2/neu signaling in sensitivity to tumor necrosis factor-related apoptosis-inducing ligand: enhancement of TRAIL-mediated apoptosis by amiloride.	Amiloride	146-155	erb-b2 receptor tyrosine kinase 2	Homo sapiens	8-17
16059913-0	2005	Role of HER-2/neu signaling in sensitivity to tumor necrosis factor-related apoptosis-inducing ligand: enhancement of TRAIL-mediated apoptosis by amiloride.	Amiloride	146-155	TNF superfamily member 10	Homo sapiens	118-123
16059913-3	2005	In this study, we observed that amiloride, a current clinically used diuretic drug, which had little or no cytotoxicity, sensitized TRAIL-resistant human prostate adenocarcinoma LNCaP and human ovarian adenocarcinoma SK-OV-3 cells.	Amiloride	32-41	TNF superfamily member 10	Homo sapiens	132-137
16059913-4	2005	The TRAIL-mediated activation of caspase, and PARP cleavage, were promoted in the presence of amiloride.	Amiloride	94-103	TNF superfamily member 10	Homo sapiens	4-9
16059913-4	2005	The TRAIL-mediated activation of caspase, and PARP cleavage, were promoted in the presence of amiloride.	Amiloride	94-103	collagen type XI alpha 2 chain	Homo sapiens	46-50
16059913-6	2005	However, amiloride dephosphorylated HER-2/neu tyrosine kinase as well as Akt, an anti-apoptotic protein.	Amiloride	9-18	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-41
16059913-6	2005	However, amiloride dephosphorylated HER-2/neu tyrosine kinase as well as Akt, an anti-apoptotic protein.	Amiloride	9-18	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-45
16059913-7	2005	Interestingly, amiloride also dephosphorylated PI3K and PDK-1 kinases along with PP1alpha phosphatase.	Amiloride	15-24	pyruvate dehydrogenase kinase 1	Homo sapiens	56-61
16059913-9	2005	Taken together, the present studies suggest that amiloride enhances TRAIL-induced cytotoxicity by inhibiting phosphorylation of the HER-2/neu-PI3K-Akt pathway-associated kinases and phosphatase.	Amiloride	49-58	TNF superfamily member 10	Homo sapiens	68-73
16059913-9	2005	Taken together, the present studies suggest that amiloride enhances TRAIL-induced cytotoxicity by inhibiting phosphorylation of the HER-2/neu-PI3K-Akt pathway-associated kinases and phosphatase.	Amiloride	49-58	erb-b2 receptor tyrosine kinase 2	Homo sapiens	132-137
16059913-9	2005	Taken together, the present studies suggest that amiloride enhances TRAIL-induced cytotoxicity by inhibiting phosphorylation of the HER-2/neu-PI3K-Akt pathway-associated kinases and phosphatase.	Amiloride	49-58	erb-b2 receptor tyrosine kinase 2	Homo sapiens	138-141
16027156-4	2005	Coexpression of rat ENaC with human CFTR or the human Cl- channel CLC-0 caused inhibition of amiloride-sensitive Na+ currents after cAMP-dependent stimulation and in the presence of a 100 mM bath Cl- concentration.	Amiloride	93-102	CF transmembrane conductance regulator	Homo sapiens	36-40
15857902-1	2005	Amiloride-sensitive, epithelial Na(+) channel (ENaC)-mediated, active absorption of Na(+) is elevated in the airway epithelium of cystic fibrosis (CF) patients, resulting in excess fluid removal from the airway lumen.	Amiloride	0-9	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	47-51
15919715-15	2005	Taken together, these results show that phenformin and AICAR suppress amiloride-sensitive Na+ transport across H441 cells via a pathway that includes activation of AMPK and inhibition of both apical Na+ entry through ENaC and basolateral Na+ extrusion via the Na+,K+-ATPase.	Amiloride	70-79	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	164-168
15843443-5	2005	After 1.5 microM PAPA-NONOate was applied, amiloride-sensitive short-circuit current measurements decreased 29% in A6 cells and 44% in M1 cells.	Amiloride	43-52	pappalysin 1	Homo sapiens	17-21
15843443-7	2005	Subsequent application of PAPA-NONOate to amiloride-treated control (no NONOate) A6 and M1 cells did not further decrease transepithelial current.	Amiloride	42-51	pappalysin 1	Homo sapiens	26-30
16463140-1	2005	We previously showed that activation of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) Cl- conductance (gCFTR) supports parallel activation of amiloride-sensitive epithelial Na+ channel (ENaC) in the native human sweat duct.	Amiloride	164-173	CF transmembrane conductance regulator	Homo sapiens	44-100
16463140-1	2005	We previously showed that activation of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) Cl- conductance (gCFTR) supports parallel activation of amiloride-sensitive epithelial Na+ channel (ENaC) in the native human sweat duct.	Amiloride	164-173	CF transmembrane conductance regulator	Homo sapiens	102-106
16230521-9	2005	Amyloride at 10(-4) M augmented the pH decrease in response to CF6, whereas efrapeptin at 10(-5) M blocked it.	Amiloride	0-9	ATP synthase peripheral stalk subunit F6	Homo sapiens	63-66
16083715-6	2005	Ion substitution studies and the sodium transport inhibitor amiloride showed that sodium movement primarily accounted for the potentiating effect of EGF in DSS-treated tissues, despite decreased sodium channel expression.	Amiloride	60-69	epidermal growth factor	Mus musculus	149-152
15716323-9	2005	Interestingly, cells expressing the Myo1c constructs had modulated antidiuretic hormone (ADH)-stimulated short-circuit current and showed little inhibition of short-circuit current with amiloride addition.	Amiloride	186-195	myosin IC	Mus musculus	36-41
16007095-6	2005	Treating cultured collecting ducts with TZDs increased amiloride-sensitive Na(+) absorption and Scnn1g mRNA (encoding the epithelial Na(+) channel ENaCgamma) expression through a PPARgamma-dependent pathway.	Amiloride	55-64	peroxisome proliferator activated receptor gamma	Mus musculus	179-188
15937449-1	2005	INTRODUCTION: The aim of the study was to compare the effects of amiloride and bumetanide on the baseline transepithelial electrical potential difference (PD) and changes in PD during mechanical stimulation (dPD) in isolated cecal and colonic wall of rabbits.	Amiloride	65-74	dachs	Drosophila melanogaster	155-157
16129916-5	2005	Preincubation of the tissue in the presence of amiloride diminished the PD and dPD by about 50% and 64%, respectively, and in the presence of bumetanide, both PD and dPD were lower by about 30%.	Amiloride	47-56	dachs	Drosophila melanogaster	72-74
16129916-5	2005	Preincubation of the tissue in the presence of amiloride diminished the PD and dPD by about 50% and 64%, respectively, and in the presence of bumetanide, both PD and dPD were lower by about 30%.	Amiloride	47-56	dachs	Drosophila melanogaster	79-82
16129916-5	2005	Preincubation of the tissue in the presence of amiloride diminished the PD and dPD by about 50% and 64%, respectively, and in the presence of bumetanide, both PD and dPD were lower by about 30%.	Amiloride	47-56	dachs	Drosophila melanogaster	80-82
15937449-7	2005	Addition of amiloride to the stimulation fluid only diminished the PD and dPD values in the colon, whereas addition of bumetanide to the stimulation fluid only diminished the PD and dPD values in the cecum.	Amiloride	12-21	dachs	Drosophila melanogaster	67-69
15681398-4	2005	In vitro experiments showed that inhibition of endogenous serine proteases by apical aprotinin 1) decreased ENaC-mediated currents in primary cultures of rat and mouse alveolar epithelial cells without affecting the abundance nor the electrophoretic migration pattern of biotinylated alpha- and beta-ENaC expressed at the cell surface and 2) suppressed the increase in amiloride-sensitive short-circuit current induced by the beta2-agonist terbutaline.	Amiloride	369-378	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	108-112
16176066-7	2005	When blood vessels were washed out with saline perfusion brain CAT activity significantly increased up to 6 h after trauma, decreasing significantly by 24 h; GAD or AMI administration preserved CAT activity 24 h after TBI.	Amiloride	165-168	catalase	Rattus norvegicus	194-197
15928403-0	2005	Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor.	Amiloride	35-44	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-26
15928404-0	2005	Ethanol modulates the VR-1 variant amiloride-insensitive salt taste receptor.	Amiloride	35-44	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	22-26
15755725-6	2005	IL-1beta significantly reduced the amiloride-sensitive fraction of the transepithelial current and sodium transport across rat ATII cell monolayers.	Amiloride	35-44	interleukin 1 beta	Rattus norvegicus	0-8
15626748-4	2005	Apical trypsin and human neutrophil elastase, but not agonists of protease activated receptors, increased Na(+) and Cl(-) short-circuit currents (I(sc)) and transepithelial resistance (R(TE)) across human bronchial and nasal epithelial cells and rat alveolar type II cells, mounted in Ussing chambers, for at least 2 h. The increase in I(sc) was fully reversed by amiloride and glibenclamide.	Amiloride	364-373	elastase, neutrophil expressed	Homo sapiens	25-44
15753079-4	2005	Similarly, pharmacological AMPK activation or overexpression of an activating AMPK mutant in mpkCCD(c14) cells inhibited amiloride-sensitive short circuit currents.	Amiloride	121-130	protein kinase, AMP-activated, alpha 2 catalytic subunit S homeolog	Xenopus laevis	27-31
15753079-4	2005	Similarly, pharmacological AMPK activation or overexpression of an activating AMPK mutant in mpkCCD(c14) cells inhibited amiloride-sensitive short circuit currents.	Amiloride	121-130	protein kinase, AMP-activated, alpha 2 catalytic subunit S homeolog	Xenopus laevis	78-82
15634742-2	2005	The addition of epidermal growth factor (EGF) to the basolateral bathing solution of polarized monolayers reduced amiloride-sensitive short-circuit current (I(sc)) by 15-25%, whereas the addition of ATP to the apical bathing solution decreased I(sc) by 40-60%.	Amiloride	114-123	epidermal growth factor	Mus musculus	16-39
15634742-2	2005	The addition of epidermal growth factor (EGF) to the basolateral bathing solution of polarized monolayers reduced amiloride-sensitive short-circuit current (I(sc)) by 15-25%, whereas the addition of ATP to the apical bathing solution decreased I(sc) by 40-60%.	Amiloride	114-123	epidermal growth factor	Mus musculus	41-44
15634742-3	2005	Direct activation of PKC with phorbol 12-myristate 13-acetate (PMA) and mobilization of intracellular calcium with 2,5-di-tert-butyl-hydroquinone (DBHQ) reduced amiloride-sensitive I(sc) in mCT12 monolayers by 46 +/- 4% (n = 8) and 22 +/- 2% (n = 8), respectively.	Amiloride	161-170	solute carrier family 16 (monocarboxylic acid transporters), member 12	Mus musculus	190-195
15634742-8	2005	The results of these studies demonstrate that acute inhibition of amiloride-sensitive sodium transport by extracelluar ATP and EGF involves ERK1/2 activation and suggests a role for MAP kinase signaling as a negative regulator of electrogenic sodium absorption in epithelia.	Amiloride	66-75	epidermal growth factor	Mus musculus	127-130
15634742-8	2005	The results of these studies demonstrate that acute inhibition of amiloride-sensitive sodium transport by extracelluar ATP and EGF involves ERK1/2 activation and suggests a role for MAP kinase signaling as a negative regulator of electrogenic sodium absorption in epithelia.	Amiloride	66-75	mitogen-activated protein kinase 3	Mus musculus	140-146
16036511-0	2005	Amelioration of experimental colitis by Na-H exchanger-1 inhibitor amiloride is associated with reversal of IL-1ss and ERK mitogen-activated protein kinase.	Amiloride	67-76	solute carrier family 9 member A1	Rattus norvegicus	40-56
16036511-0	2005	Amelioration of experimental colitis by Na-H exchanger-1 inhibitor amiloride is associated with reversal of IL-1ss and ERK mitogen-activated protein kinase.	Amiloride	67-76	Eph receptor B1	Rattus norvegicus	119-122
16036511-3	2005	The effects of amiloride, an inhibitor of NHE-1, on colitis were examined in this study.	Amiloride	15-24	solute carrier family 9 member A1	Rattus norvegicus	42-47
16036511-11	2005	Amiloride significantly reversed the colitis-reduced contractility and induction of MPO activity, NHE-1, IL-1ss and ERK, but not of p38 in inflamed colonic smooth muscle.	Amiloride	0-9	myeloperoxidase	Rattus norvegicus	84-87
16036511-11	2005	Amiloride significantly reversed the colitis-reduced contractility and induction of MPO activity, NHE-1, IL-1ss and ERK, but not of p38 in inflamed colonic smooth muscle.	Amiloride	0-9	solute carrier family 9 member A1	Rattus norvegicus	98-103
16036511-11	2005	Amiloride significantly reversed the colitis-reduced contractility and induction of MPO activity, NHE-1, IL-1ss and ERK, but not of p38 in inflamed colonic smooth muscle.	Amiloride	0-9	Eph receptor B1	Rattus norvegicus	105-119
15843607-6	2005	First, TRPA1 and the hair cell transducer share a unique set of pore properties not described for any other channel (block by gadolinium, amiloride, gentamicin, and ruthenium red, a ranging conductance of approximately 100 pS that is reduced to 54% by calcium, permeating calcium-induced potentiation followed by closure, and reopening by depolarization), supporting a direct role of TRPA1 as a pore-forming subunit of the hair cell transducer.	Amiloride	138-147	transient receptor potential cation channel subfamily A member 1	Homo sapiens	7-12
15509720-2	2005	We describe the syntheses, characterization, and NHE inhibitory activities of a novel class of amiloride derivatives where peptides are conjugated to the amiloride C(5) amino group.	Amiloride	95-104	solute carrier family 9 member C1	Homo sapiens	49-52
15703175-6	2005	We also found that KB-R7943 or 2",4"-dichlorobenzamil, an amiloride analog that inhibits the Na(+)/Ca(2+) exchanger activity, blocked the TGF-beta1- and des-Arg(10)-kallidin-stimulated increases of CTGF mRNA.	Amiloride	58-67	nascent polypeptide associated complex subunit alpha 2	Homo sapiens	93-104
15703175-6	2005	We also found that KB-R7943 or 2",4"-dichlorobenzamil, an amiloride analog that inhibits the Na(+)/Ca(2+) exchanger activity, blocked the TGF-beta1- and des-Arg(10)-kallidin-stimulated increases of CTGF mRNA.	Amiloride	58-67	transforming growth factor beta 1	Homo sapiens	138-147
15703175-6	2005	We also found that KB-R7943 or 2",4"-dichlorobenzamil, an amiloride analog that inhibits the Na(+)/Ca(2+) exchanger activity, blocked the TGF-beta1- and des-Arg(10)-kallidin-stimulated increases of CTGF mRNA.	Amiloride	58-67	cellular communication network factor 2	Homo sapiens	198-202
15644322-1	2005	In the renal medullary thick ascending limb (MTAL), inhibiting the basolateral NHE1 Na(+)/H(+) exchanger with amiloride or nerve growth factor (NGF) results secondarily in inhibition of the apical NHE3 Na(+)/H(+) exchanger, thereby decreasing transepithelial HCO3- absorption.	Amiloride	110-119	solute carrier family 9 member A1	Rattus norvegicus	79-83
15644322-1	2005	In the renal medullary thick ascending limb (MTAL), inhibiting the basolateral NHE1 Na(+)/H(+) exchanger with amiloride or nerve growth factor (NGF) results secondarily in inhibition of the apical NHE3 Na(+)/H(+) exchanger, thereby decreasing transepithelial HCO3- absorption.	Amiloride	110-119	solute carrier family 9 member A3	Rattus norvegicus	197-201
15522985-1	2005	Amiloride-sensitive sodium entry, via the epithelial sodium channel (ENaC), is the rate-limiting step for Na+ absorption in kidney collecting ducts, and epidermal growth factor (EGF) inhibits Na+ transport and ENaC expression.	Amiloride	0-9	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	69-73
15522985-1	2005	Amiloride-sensitive sodium entry, via the epithelial sodium channel (ENaC), is the rate-limiting step for Na+ absorption in kidney collecting ducts, and epidermal growth factor (EGF) inhibits Na+ transport and ENaC expression.	Amiloride	0-9	epidermal growth factor	Mus musculus	178-181
15522985-1	2005	Amiloride-sensitive sodium entry, via the epithelial sodium channel (ENaC), is the rate-limiting step for Na+ absorption in kidney collecting ducts, and epidermal growth factor (EGF) inhibits Na+ transport and ENaC expression.	Amiloride	0-9	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	210-214
15550504-13	2005	Inhibition of protein kinase C with 1 microm bi-sindolylmaleimide I and/or inhibition of NHE1 with 100 microm amiloride abolished aldosterone vasoconstrictor action of resistance mesenteric arteries.	Amiloride	110-119	solute carrier family 9 member A1	Homo sapiens	89-93
16172524-4	2005	The deduced amino acid sequence of RhNHX1 is 74.1% identical to that of a vacuolar Na+/H+ antiporter of Arabidopsis thaliana, AtNHX1, and contains the consensus amiloride-binding domain.	Amiloride	161-170	Na+/H+ exchanger 1	Arabidopsis thaliana	83-100
16172524-4	2005	The deduced amino acid sequence of RhNHX1 is 74.1% identical to that of a vacuolar Na+/H+ antiporter of Arabidopsis thaliana, AtNHX1, and contains the consensus amiloride-binding domain.	Amiloride	161-170	Na+/H+ exchanger 1	Arabidopsis thaliana	126-132
15690192-1	2005	Low-renin hypertension responsive to amiloride-thiazide therapy in a 4-year-old Afro-Haitian girl suggested Liddle syndrome.	Amiloride	37-46	renin	Homo sapiens	4-9
15629126-2	2005	Amiloride, an antikaliuretic-diuretic agent, has recently entered the realm of NF-kappaB as a key player in regulating the molecular association of fluid dynamics with inflammation and oxidative stress.	Amiloride	0-9	nuclear factor kappa B subunit 1	Homo sapiens	79-88
15629126-3	2005	With the identification of flanking regions encoding the amiloride-sensitive channels that are NF-kappaB-responsive, a new theme emerges which underlies the significance of this association.	Amiloride	57-66	nuclear factor kappa B subunit 1	Homo sapiens	95-104
15629126-6	2005	It is the mainstream of this survey, therefore, to outline current advances on the biophysics and nature of the interaction existing between amiloride, amiloride-sensitive channels, and NF-kappaB, while searching for potential molecular mechanisms.	Amiloride	141-150	nuclear factor kappa B subunit 1	Homo sapiens	186-195
15654262-7	2005	HOE-140, a selective antagonist of the bradykinin B2 receptor, and amiloride, a Na+/H+ exchanger inhibitor, abolished angiotensin II-induced relaxation.	Amiloride	67-76	angiotensinogen	Rattus norvegicus	118-132
15701794-0	2005	Amiloride uptake and toxicity in fission yeast are caused by the pyridoxine transporter encoded by bsu1+ (car1+).	Amiloride	0-9	arginase	Saccharomyces cerevisiae S288C	106-110
15701794-2	2005	Previous work has established that amiloride sensitivity is caused by expression of car1+, which encodes a protein with similarity to plasma membrane drug/proton antiporters from the multidrug resistance family.	Amiloride	35-44	arginase	Saccharomyces cerevisiae S288C	84-88
15558024-0	2005	Amiloride augments TRAIL-induced apoptotic death by inhibiting phosphorylation of kinases and phosphatases associated with the P13K-Akt pathway.	Amiloride	0-9	TNF superfamily member 10	Homo sapiens	19-24
15475592-10	2005	This is at least partially due to a synergistic effect of GI262570 and the rebound from amiloride treatment on ENaCalpha expression.	Amiloride	88-97	sodium channel epithelial 1 subunit alpha	Rattus norvegicus	111-120
15607733-0	2005	Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation.	Amiloride	0-9	TNF superfamily member 10	Homo sapiens	22-27
15607733-0	2005	Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation.	Amiloride	0-9	AKT serine/threonine kinase 1	Homo sapiens	98-101
15607733-2	2005	In this study, we investigated whether the Na(+)/H(+) exchanger inhibitor, amiloride, promotes TRAIL-induced apoptotic death both in sensitive and resistant tumor cells, HeLa and LNCaP cells, respectively, and its underlying molecular mechanism.	Amiloride	75-84	TNF superfamily member 10	Homo sapiens	95-100
15607733-3	2005	Amiloride enhanced TRAIL-induced apoptosis and activation of caspase-3 and -8 in both cells.	Amiloride	0-9	TNF superfamily member 10	Homo sapiens	19-24
15607733-3	2005	Amiloride enhanced TRAIL-induced apoptosis and activation of caspase-3 and -8 in both cells.	Amiloride	0-9	caspase 3	Homo sapiens	61-77
15607733-5	2005	Moreover, amiloride-induced intracellular acidification, and inhibited the phosphorylated activation of the serine/threonine kinase Akt, which is known to promote cell survival, in both tumor cells.	Amiloride	10-19	AKT serine/threonine kinase 1	Homo sapiens	132-135
15607733-6	2005	These data suggest that amiloride sensitizes both tumor cells to TRAIL-induced apoptosis by promoting Akt dephosphorylation and caspase-8 activation via the intracellular acidification and that Na(+)/H(+) exchanger inhibitors may play an important role in the anti-cancer activity of TRAIL, especially, in TRAIL-resistant tumors with highly active and expressed Akt.	Amiloride	24-33	TNF superfamily member 10	Homo sapiens	65-70
15607733-6	2005	These data suggest that amiloride sensitizes both tumor cells to TRAIL-induced apoptosis by promoting Akt dephosphorylation and caspase-8 activation via the intracellular acidification and that Na(+)/H(+) exchanger inhibitors may play an important role in the anti-cancer activity of TRAIL, especially, in TRAIL-resistant tumors with highly active and expressed Akt.	Amiloride	24-33	AKT serine/threonine kinase 1	Homo sapiens	102-105
15607733-6	2005	These data suggest that amiloride sensitizes both tumor cells to TRAIL-induced apoptosis by promoting Akt dephosphorylation and caspase-8 activation via the intracellular acidification and that Na(+)/H(+) exchanger inhibitors may play an important role in the anti-cancer activity of TRAIL, especially, in TRAIL-resistant tumors with highly active and expressed Akt.	Amiloride	24-33	caspase 8	Homo sapiens	128-137
15607733-6	2005	These data suggest that amiloride sensitizes both tumor cells to TRAIL-induced apoptosis by promoting Akt dephosphorylation and caspase-8 activation via the intracellular acidification and that Na(+)/H(+) exchanger inhibitors may play an important role in the anti-cancer activity of TRAIL, especially, in TRAIL-resistant tumors with highly active and expressed Akt.	Amiloride	24-33	TNF superfamily member 10	Homo sapiens	284-289
15607733-6	2005	These data suggest that amiloride sensitizes both tumor cells to TRAIL-induced apoptosis by promoting Akt dephosphorylation and caspase-8 activation via the intracellular acidification and that Na(+)/H(+) exchanger inhibitors may play an important role in the anti-cancer activity of TRAIL, especially, in TRAIL-resistant tumors with highly active and expressed Akt.	Amiloride	24-33	TNF superfamily member 10	Homo sapiens	284-289
15607733-6	2005	These data suggest that amiloride sensitizes both tumor cells to TRAIL-induced apoptosis by promoting Akt dephosphorylation and caspase-8 activation via the intracellular acidification and that Na(+)/H(+) exchanger inhibitors may play an important role in the anti-cancer activity of TRAIL, especially, in TRAIL-resistant tumors with highly active and expressed Akt.	Amiloride	24-33	AKT serine/threonine kinase 1	Homo sapiens	362-365
15558024-0	2005	Amiloride augments TRAIL-induced apoptotic death by inhibiting phosphorylation of kinases and phosphatases associated with the P13K-Akt pathway.	Amiloride	0-9	AKT serine/threonine kinase 1	Homo sapiens	132-135
15558024-2	2005	In this study, we examined whether amiloride, an inhibitor of the Na(+)/H(+) antiporter capable of lowering the intracellular pH (pHi), can potentiate TRAIL-induced apoptotic death.	Amiloride	35-44	glucose-6-phosphate isomerase	Homo sapiens	130-133
15558024-2	2005	In this study, we examined whether amiloride, an inhibitor of the Na(+)/H(+) antiporter capable of lowering the intracellular pH (pHi), can potentiate TRAIL-induced apoptotic death.	Amiloride	35-44	TNF superfamily member 10	Homo sapiens	151-156
15558024-3	2005	Human prostate adenocarcinoma DU-145 cells were treated with various concentrations of TRAIL (10-200 ng/ml) and/or amiloride (0.1-1 mM) for 4 h. Amiloride, which caused little or no cytotoxicity by itself, enhanced TRAIL-induced apoptosis.	Amiloride	145-154	TNF superfamily member 10	Homo sapiens	87-92
15558024-4	2005	The TRAIL-mediated activation of caspase, and PARP (poly (ADP-ribose) polymerase) cleavage were both promoted by amiloride.	Amiloride	113-122	TNF superfamily member 10	Homo sapiens	4-9
15558024-4	2005	The TRAIL-mediated activation of caspase, and PARP (poly (ADP-ribose) polymerase) cleavage were both promoted by amiloride.	Amiloride	113-122	poly(ADP-ribose) polymerase 1	Homo sapiens	46-50
15558024-4	2005	The TRAIL-mediated activation of caspase, and PARP (poly (ADP-ribose) polymerase) cleavage were both promoted by amiloride.	Amiloride	113-122	poly(ADP-ribose) polymerase 1	Homo sapiens	52-80
15558024-6	2005	However, unlike pHe, amiloride promoted the dephosphorylation of Akt.	Amiloride	21-30	AKT serine/threonine kinase 1	Homo sapiens	65-68
15558024-7	2005	Interestingly, amiloride also induced the dephosphorylation of P13K (phosphatidylinositol 3-kinase) and PDK-1 (phosphoinositide-dependent kinase-1) kinases along with PTEN (phosphatase and tensin homolog deleted on chromosome 10) and PP1alpha phosphatases.	Amiloride	15-24	pyruvate dehydrogenase kinase 1	Homo sapiens	104-109
15558024-7	2005	Interestingly, amiloride also induced the dephosphorylation of P13K (phosphatidylinositol 3-kinase) and PDK-1 (phosphoinositide-dependent kinase-1) kinases along with PTEN (phosphatase and tensin homolog deleted on chromosome 10) and PP1alpha phosphatases.	Amiloride	15-24	pyruvate dehydrogenase kinase 1	Homo sapiens	111-146
15558024-7	2005	Interestingly, amiloride also induced the dephosphorylation of P13K (phosphatidylinositol 3-kinase) and PDK-1 (phosphoinositide-dependent kinase-1) kinases along with PTEN (phosphatase and tensin homolog deleted on chromosome 10) and PP1alpha phosphatases.	Amiloride	15-24	phosphatase and tensin homolog	Homo sapiens	167-171
15558024-9	2005	Taken together, the present studies suggest that amiloride enhances TRAIL-induced cytotoxicity by inhibiting phosphorylation of the PI3K-Akt pathway-associated kinases and phosphatases.	Amiloride	49-58	TNF superfamily member 10	Homo sapiens	68-73
15558024-9	2005	Taken together, the present studies suggest that amiloride enhances TRAIL-induced cytotoxicity by inhibiting phosphorylation of the PI3K-Akt pathway-associated kinases and phosphatases.	Amiloride	49-58	AKT serine/threonine kinase 1	Homo sapiens	137-140
15866288-0	2005	Effects of inhibition of urokinase-type plasminogen activator (u-PA) by amiloride in the cornea and tear fluid of eyes irradiated with UVB.	Amiloride	72-81	urokinase-type plasminogen activator	Oryctolagus cuniculus	25-61
15866288-0	2005	Effects of inhibition of urokinase-type plasminogen activator (u-PA) by amiloride in the cornea and tear fluid of eyes irradiated with UVB.	Amiloride	72-81	urokinase-type plasminogen activator	Oryctolagus cuniculus	63-67
15866288-1	2005	The purpose of the present study was to test our hypothesis that amiloride, a specific u-PA inhibitor, effectively decreases u-PA activity in cornea as well as in tear fluid and favourably affects corneal healing.	Amiloride	65-74	urokinase-type plasminogen activator	Oryctolagus cuniculus	87-91
15866288-1	2005	The purpose of the present study was to test our hypothesis that amiloride, a specific u-PA inhibitor, effectively decreases u-PA activity in cornea as well as in tear fluid and favourably affects corneal healing.	Amiloride	65-74	urokinase-type plasminogen activator	Oryctolagus cuniculus	125-129
15866288-9	2005	When amiloride was dropped on the eye surface on the first day of irradiation and subsequently daily until the end of the experiment, u-PA activity in both cornea and tear fluid was strongly inhibited.	Amiloride	5-14	urokinase-type plasminogen activator	Oryctolagus cuniculus	134-138
15866288-13	2005	In conclusion, early application of amiloride inhibited u-PA activity in UVB-irradiated corneas as well as in tear fluid and diminished the development of corneal pathology.	Amiloride	36-45	urokinase-type plasminogen activator	Oryctolagus cuniculus	56-60
16738531-2	2005	This review summarizes the effects of vasopressin on Na+ transport mediated by the amiloride-sensitive epithelial sodium channel (ENaC) and the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel in immortalized or primary cultured cortical collecting duct cells, expressing either the wild-type ENaC subunits, or mutations, or deletions of the PY domain of the beta- or gamma-ENaC subunits responsible for Liddle"s syndrome, an inherited form of hypertension due to excessive salt absorption.	Amiloride	83-92	arginine vasopressin	Homo sapiens	38-49
16020936-4	2005	Amiloride, an ENaC-blocking drug, corrects the abnormal rate of sodium transport in isolated perfused CCD from puromycin aminonucleoside (PAN)-treated rats.	Amiloride	0-9	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	14-18
15610243-8	2005	TGF-beta1 reduced endogenous prostasin mRNA and protein expression in M-1 cells by 50 +/- 12% and 44 +/- 12%, respectively, and the amiloride-sensitive (22)Na uptake by 35.9 +/- 4.8%.	Amiloride	132-141	transforming growth factor, beta 1	Rattus norvegicus	0-9
15466959-7	2004	Histologically, treatment with amiloride significantly increased hippocampal caspase-3 expression (apoptosis), axonal swellings in the medulla and the degree of dark cell change (cell stress) in the cortex.	Amiloride	31-40	caspase 3	Rattus norvegicus	77-86
15292047-7	2004	Thus the regulatory defect in NHE1(-/-) MTALs is specific for factors (bath amiloride and NGF) shown previously to inhibit HCO(3)(-) absorption through primary effects on basolateral Na(+)/H(+) exchange.	Amiloride	76-85	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	30-34
15574747-9	2004	Subcutaneous injection of amiloride (1 mm) also significantly inhibited the pain induced by iontophoresis of acid, suggesting an involvement of acid-sensing ion channel (ASIC) receptors.	Amiloride	26-35	acid sensing ion channel subunit 1	Homo sapiens	144-168
15574747-9	2004	Subcutaneous injection of amiloride (1 mm) also significantly inhibited the pain induced by iontophoresis of acid, suggesting an involvement of acid-sensing ion channel (ASIC) receptors.	Amiloride	26-35	acid sensing ion channel subunit 1	Homo sapiens	170-174
15381679-6	2004	Moreover, inhibition of ENaC with amiloride (1 micromol/L) and benzamil (30 nmol/L, 1 micromol), an amiloride analog, blocked myogenic constriction in isolated rat cerebral arteries.	Amiloride	34-43	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	24-28
15584764-6	2004	We elucidated different amilorides as potential drugs to inhibit channel activity of Vpu.	Amiloride	24-34	Vpu	Human immunodeficiency virus 1	85-88
15292047-5	2004	Basolateral addition of 10 microM amiloride or 0.7 nM NGF decreased HCO(3)(-) absorption by 45-49% in wild-type MTALs but had no effect on HCO(3)(-) absorption in NHE1(-/-) MTALs.	Amiloride	34-43	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	163-167
15381679-6	2004	Moreover, inhibition of ENaC with amiloride (1 micromol/L) and benzamil (30 nmol/L, 1 micromol), an amiloride analog, blocked myogenic constriction in isolated rat cerebral arteries.	Amiloride	100-109	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	24-28
15543335-4	2004	This activation is prevented by amiloride, an inhibitor of u-PA, and epsilon-aminocaproic acid, epsilon-ACA, a lysine analogue that blocks plasminogen binding to PMNs.	Amiloride	32-41	plasminogen activator, urokinase	Homo sapiens	59-63
15535137-8	2004	Furthermore, experiments of inhibition of myoblast fusion with amiloride, a type T calcium channel antagonist, showed that dysferlin levels were lower in treated than in non-treated cultures (p < 0.001), demonstrating that dysferlin expression reached peak levels upon differentiation into myotubes.	Amiloride	63-72	dysferlin	Homo sapiens	123-132
15292220-8	2004	Co-injection of IKKbeta significantly increased the amiloride-sensitive current above controls.	Amiloride	52-61	inhibitor of kappaB kinase beta	Mus musculus	16-23
15535137-8	2004	Furthermore, experiments of inhibition of myoblast fusion with amiloride, a type T calcium channel antagonist, showed that dysferlin levels were lower in treated than in non-treated cultures (p < 0.001), demonstrating that dysferlin expression reached peak levels upon differentiation into myotubes.	Amiloride	63-72	dysferlin	Homo sapiens	226-235
15140751-6	2004	In contrast, ethylisopropyl amiloride (EIPA, 100 nM) or amiloride (10 microM) completely abolished the pH(i) recovery by NHE.	Amiloride	28-37	solute carrier family 9 member C1	Homo sapiens	121-124
15452200-4	2004	Expression of a constitutively active mutant of SGK1 (SGK1T(S425D)) induced a sixfold increase in amiloride-sensitive short-circuit current (Isc).	Amiloride	98-107	serum/glucocorticoid regulated kinase 1	Homo sapiens	48-52
15302576-10	2004	uPA activity appears to contribute to invasiveness at least through Matrigel, as antibody to uPA or amiloride limited the transmigration.	Amiloride	100-109	plasminogen activator, urokinase	Mus musculus	0-3
15140763-9	2004	Both the phosphorylation level and the accompanying amiloride-sensitive Na(+) currents could be further enhanced to approximately the same levels by coexpressing Sgk1.	Amiloride	52-61	serum/glucocorticoid regulated kinase 1	Homo sapiens	162-166
15313144-8	2004	IL-8 secretion was not altered by bradykinin or adenosine, but amiloride significantly decreased IL-8 secretion.	Amiloride	63-72	C-X-C motif chemokine ligand 8	Homo sapiens	97-101
15210697-8	2004	When treated with amiloride to block the Na(+)/H(+) exchanger, intracellular pH in hTE acidified at significantly higher rates than in Calu-3, and treatment with AEBSF blocked acidification.	Amiloride	18-27	acyl-CoA thioesterase 8	Homo sapiens	83-86
15192115-5	2004	Inhibition of NHE activity by amiloride inhibits regeneration of alkaline microdomains after cytoplasmic acidification, whereas the inhibition of CAII activity with ethoxyzolamide inhibits acidification of dendrites.	Amiloride	30-39	solute carrier family 9 member C1	Homo sapiens	14-17
15314687-7	2004	Amiloride or furosemide reduced BP in CD ET-1 KO mice on a normal or high-Na diet and prevented excessive Na retention in salt-loaded CD ET-1 KO mice.	Amiloride	0-9	endothelin 1	Mus musculus	41-45
15314687-7	2004	Amiloride or furosemide reduced BP in CD ET-1 KO mice on a normal or high-Na diet and prevented excessive Na retention in salt-loaded CD ET-1 KO mice.	Amiloride	0-9	endothelin 1	Mus musculus	137-141
15010500-8	2004	These findings indicated that amiloride"s cytotoxic effects on glioma cells are independent of its ability to inhibit NHE1 or to reduce intracellular pHi.	Amiloride	30-39	glucose-6-phosphate isomerase	Homo sapiens	150-153
15146042-0	2004	The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant.	Amiloride	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	74-94
15146042-5	2004	The results indicate that the amiloride-insensitive salt taste receptor is a constitutively active non-selective cation channel derived from the VR-1 gene.	Amiloride	30-39	transient receptor potential cation channel subfamily V member 1	Homo sapiens	145-149
15146042-10	2004	VR-1 knockout mice demonstrate no functional amiloride-insensitive salt taste receptor and no salt taste sensitivity to vanilloids and temperature.	Amiloride	45-54	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-4
15484827-5	2004	Oocyte electrophysiology demonstrated that the ASIC2a/ASIC2b channel generated amiloride-insensitive currents at pH 2.0.	Amiloride	79-88	acid sensing ion channel subunit 2	Homo sapiens	47-53
15484827-5	2004	Oocyte electrophysiology demonstrated that the ASIC2a/ASIC2b channel generated amiloride-insensitive currents at pH 2.0.	Amiloride	79-88	acid sensing ion channel subunit 2	Homo sapiens	47-52
15484827-8	2004	In our psychophysical experiments, direct infusion of acidic solutions (pH > or = 6.0) into human skin caused localized pain, which was blocked by amiloride, an inhibitor of ASICs, but not by capsazepine, an inhibitor of TRPV1.	Amiloride	150-159	transient receptor potential cation channel subfamily V member 1	Homo sapiens	224-229
15010500-9	2004	The amiloride derivative 2,4 dichlorobenzamil (DCB) inhibits the sodium-calcium exchanger (NCX) and was both antiproliferative and cytotoxic to glioma cells at low doses (20 microM).	Amiloride	4-13	T cell leukemia homeobox 2	Homo sapiens	91-94
15010500-11	2004	It is proposed that DCB (20 microM) and amiloride (500 microM) impair calcium efflux by NCX, leading to elevations of intracellular calcium that initiate a morphologically necrotic, predominantly caspase-independent glioma cell death.	Amiloride	40-49	T cell leukemia homeobox 2	Homo sapiens	88-91
15084585-2	2004	The amiloride sensitivity, Na(+) conductance, and critical domains for gating are characterized as a cross between proton-activated Na(+) channels and alpha-ENaC.	Amiloride	4-13	sodium channel epithelial 1 subunit alpha	Homo sapiens	151-161
15193158-6	2004	Islet pHi was altered using amiloride, removal of medium Cl-, and changing medium pH.	Amiloride	28-37	glucose-6-phosphate isomerase 1	Mus musculus	6-9
14749256-4	2004	In the present study, using the well-established Madin-Darby canine kidney C7 cell line, we tested the hypothesis that EGFR represents a negative-feedback control for chronic aldosterone-induced Na(+) reabsorption [amiloride-inhibitable short-circuit current (I(sc))].	Amiloride	215-224	epidermal growth factor receptor	Canis lupus familiaris	119-123
15207617-5	2004	DC uptake of and signalling by VLP was inhibited by amiloride or cytochalasin D (CCD), but not by filipin treatment, and was blocked by several sulfated and non-sulfated polysaccharides and anti-CD16.	Amiloride	52-61	VHL like	Homo sapiens	31-34
15608366-6	2004	Incubation of young rabbits caecum with the presence of amiloride resulted in a reduction of PD by about 17 % and dPD by about 50%, while it did not influence the electrophysiological parameters of caecum in 36-month rabbits.	Amiloride	56-65	dachs	Drosophila melanogaster	93-95
15608366-6	2004	Incubation of young rabbits caecum with the presence of amiloride resulted in a reduction of PD by about 17 % and dPD by about 50%, while it did not influence the electrophysiological parameters of caecum in 36-month rabbits.	Amiloride	56-65	dachs	Drosophila melanogaster	114-117
14969999-5	2004	Exposure of oocytes to SIN-1 (1 mM) for 5 min decreased both total Na(+) and amiloride-sensitive currents across wt and alpha(Y279A)- but not alpha(Y283A)-,beta-,gamma-rENaC.	Amiloride	77-86	MAPK associated protein 1 L homeolog	Xenopus laevis	23-28
14969999-6	2004	Furthermore, exposure to SIN-1 increased the K(i) for amiloride across wt but not alpha(Y279A)-,beta-,gamma-rENaC-injected oocytes.	Amiloride	54-63	MAPK associated protein 1 L homeolog	Xenopus laevis	25-30
14982925-7	2004	Spontaneous and vasopressin-induced Na(+) channel activity were inhibited by extracellular amiloride.	Amiloride	91-100	vasopressin	Sus scrofa	16-27
15020702-8	2004	In gain-of-function unc-105(n506) mutant cells, an amiloride-sensitive inward Na(+) current was found to be constitutively active, leading to maintained muscle depolarization.	Amiloride	51-60	Degenerin-like protein unc-105	Caenorhabditis elegans	20-27
15047694-6	2004	Oocytes co-injected with both CFTR and mENaC or hENaC expressed an amiloride-sensitive whole cell current that was decreased compared with that observed with the injection of mENaC or hENaC alone before CFTR activation with forskolin/3-isobutyl-1-methylxanthine.	Amiloride	67-76	cystic fibrosis transmembrane conductance regulator	Mus musculus	30-34
15047694-6	2004	Oocytes co-injected with both CFTR and mENaC or hENaC expressed an amiloride-sensitive whole cell current that was decreased compared with that observed with the injection of mENaC or hENaC alone before CFTR activation with forskolin/3-isobutyl-1-methylxanthine.	Amiloride	67-76	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	39-44
14607816-2	2004	C57BL/6 mice injected intraperitoneally with the specific inducible NO synthase (iNOS) inhibitor 1400W (10 mg/kg every 8 h for 72 h) exhibited decreased alveolar nitrite levels and Na(+)-dependent amiloride-sensitive alveolar fluid clearance as compared with mice injected with vehicle.	Amiloride	197-206	nitric oxide synthase 2, inducible	Mus musculus	81-85
14607816-8	2004	We concluded that NO derived from iNOS under basal conditions is necessary for amiloride-sensitive Na(+) transport across lung epithelial cells and modulates the amount of alpha and gammaENaC via post-transcriptional, cGMP-independent mechanisms.	Amiloride	79-88	nitric oxide synthase 2, inducible	Mus musculus	34-38
14656763-3	2004	Macroscopic amiloride-sensitive currents (INa) were also observed under whole cell clamp conditions.	Amiloride	12-21	internexin neuronal intermediate filament protein, alpha	Rattus norvegicus	42-45
15086906-8	2004	In sensitized distal tubule cells, TNF-stimulated sodium uptake was blocked by amiloride and PD098059, inhibitors of epithelial sodium channels and extracellular signal-related protein kinase (ERK) activation, respectively.	Amiloride	79-88	tumor necrosis factor-like	Rattus norvegicus	35-38
15086906-8	2004	In sensitized distal tubule cells, TNF-stimulated sodium uptake was blocked by amiloride and PD098059, inhibitors of epithelial sodium channels and extracellular signal-related protein kinase (ERK) activation, respectively.	Amiloride	79-88	Eph receptor B1	Rattus norvegicus	148-191
15086906-8	2004	In sensitized distal tubule cells, TNF-stimulated sodium uptake was blocked by amiloride and PD098059, inhibitors of epithelial sodium channels and extracellular signal-related protein kinase (ERK) activation, respectively.	Amiloride	79-88	Eph receptor B1	Rattus norvegicus	193-196
15082829-7	2004	Eliminating ASIC1a from neurons or treating ASIC1a-expressing cells with the ASIC blocker amiloride attenuated acidosis-induced cell injury.	Amiloride	90-99	acid sensing ion channel subunit 1	Homo sapiens	12-16
15063726-0	2004	Interaction of amiloride and one of its derivatives with Vpu from HIV-1: a molecular dynamics simulation.	Amiloride	15-24	Vpu	Human immunodeficiency virus 1	57-60
15081870-1	2004	We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can be induced through interaction of PAHs with the arylhydrocarbon receptor.	Amiloride	27-36	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	121-144
15081870-6	2004	The present data suggest that amiloride derivatives, such as EIPA, may be useful for preventing toxicity of chemical carcinogens, such as PAHs, through inhibition of CYP1 enzyme activity.	Amiloride	30-39	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	166-170
15023541-4	2004	Using several different concentrations of amiloride, aminobenzamidine and PAI-1 and the urokinase-type plasminogen activator (uPA) function-blocking antibody (3689), we showed that uPA, acting as a protease, is responsible for production of alpha6p.	Amiloride	42-51	plasminogen activator, urokinase	Homo sapiens	181-184
14630723-13	2004	The 24-h Ang II-stimulated alpha(1)-subunit promoter transcription was also inhibited by amiloride.	Amiloride	89-98	angiogenin	Rattus norvegicus	9-12
14684374-9	2004	SH-SY5Y-AT(1A) constitutively expresses amiloride-sensitive NHE and the NET.	Amiloride	40-49	solute carrier family 9 member C1	Homo sapiens	60-63
14726523-7	2004	When human ENaCdelta was expressed in Xenopus oocytes and Chinese hamster ovary cells, a reduction of extracellular pH activated this channel (half-maximal pH for an activation of 5.0), and the acid-induced current was abolished by amiloride.	Amiloride	232-241	sodium channel epithelial 1 subunit delta	Homo sapiens	11-20
14973065-10	2004	Amiloride, an uPA inhibitor, not only inhibited the activity of uPA but was also able to suppress TNF-alpha-stimulated MMP-9 activity and prevented the TNF-alpha-stimulated remodeling of the basement membrane extracellular matrix, suggesting the contribution of uPA-mediated proteolytic cascade in this process.	Amiloride	0-9	plasminogen activator, urokinase	Homo sapiens	14-17
14973065-10	2004	Amiloride, an uPA inhibitor, not only inhibited the activity of uPA but was also able to suppress TNF-alpha-stimulated MMP-9 activity and prevented the TNF-alpha-stimulated remodeling of the basement membrane extracellular matrix, suggesting the contribution of uPA-mediated proteolytic cascade in this process.	Amiloride	0-9	plasminogen activator, urokinase	Homo sapiens	64-67
14973065-10	2004	Amiloride, an uPA inhibitor, not only inhibited the activity of uPA but was also able to suppress TNF-alpha-stimulated MMP-9 activity and prevented the TNF-alpha-stimulated remodeling of the basement membrane extracellular matrix, suggesting the contribution of uPA-mediated proteolytic cascade in this process.	Amiloride	0-9	tumor necrosis factor	Homo sapiens	98-107
14973065-10	2004	Amiloride, an uPA inhibitor, not only inhibited the activity of uPA but was also able to suppress TNF-alpha-stimulated MMP-9 activity and prevented the TNF-alpha-stimulated remodeling of the basement membrane extracellular matrix, suggesting the contribution of uPA-mediated proteolytic cascade in this process.	Amiloride	0-9	matrix metallopeptidase 9	Homo sapiens	119-124
14973065-10	2004	Amiloride, an uPA inhibitor, not only inhibited the activity of uPA but was also able to suppress TNF-alpha-stimulated MMP-9 activity and prevented the TNF-alpha-stimulated remodeling of the basement membrane extracellular matrix, suggesting the contribution of uPA-mediated proteolytic cascade in this process.	Amiloride	0-9	tumor necrosis factor	Homo sapiens	152-161
14973065-10	2004	Amiloride, an uPA inhibitor, not only inhibited the activity of uPA but was also able to suppress TNF-alpha-stimulated MMP-9 activity and prevented the TNF-alpha-stimulated remodeling of the basement membrane extracellular matrix, suggesting the contribution of uPA-mediated proteolytic cascade in this process.	Amiloride	0-9	plasminogen activator, urokinase	Homo sapiens	64-67
14645214-9	2004	Murr1 inhibited amiloride-sensitive sodium current in a dose-dependent manner.	Amiloride	16-25	copper metabolism domain containing 1	Homo sapiens	0-5
14645220-4	2004	We found that endogenous Nedd4-2, but not Nedd4, negatively regulates ENaC in two epithelial cell lines (Fischer rat thyroid and H441); small interfering RNA (siRNA) against Nedd4-2 increased amiloride-sensitive Na+ current (compared with control siRNA), but Nedd4 siRNA did not.	Amiloride	192-201	NEDD4 like E3 ubiquitin protein ligase	Rattus norvegicus	174-181
14586636-4	2004	We used dissected lungs of Xenopus laevis in Ussing chambers to investigate the influence of prostaglandin E2 (PGE2) on the regulation of short-circuit current (ISC) and amiloride-sensitive sodium absorption (Iami).	Amiloride	170-179	prostaglandin E synthase 2 S homeolog	Xenopus laevis	93-109
14660613-3	2004	Because Na(+) selectivity, unitary Na(+) conductance (gamma(Na)), and amiloride sensitivity of delta-ENaC are strikingly different from those of alpha-ENaC, the hypothesis that the pre-H2 domain may contribute to these characterizations has been examined by swapping the pre-H2, H2, and both (pre-H2+H2) domains of delta- and alpha-ENaCs.	Amiloride	70-79	sodium channel, non voltage gated 1 delta subunit L homeolog	Xenopus laevis	95-105
14514522-6	2004	A strong correlation was found at different TNF-alpha concentrations between the decrease of amiloride-sensitive current and alpha-ENaC mRNA expression.	Amiloride	93-102	tumor necrosis factor	Homo sapiens	44-53
14514522-6	2004	A strong correlation was found at different TNF-alpha concentrations between the decrease of amiloride-sensitive current and alpha-ENaC mRNA expression.	Amiloride	93-102	sodium channel epithelial 1 subunit alpha	Homo sapiens	125-135
14976410-6	2004	The IC50 values for EIPA and amiloride induced decrease in NHE activity in rat and opossum kidney cells are in agreement with the observation that rat renal proximal tubules and opossum kidney cells express mainly the NHE3 isoform.	Amiloride	29-38	solute carrier family 9 member A3	Rattus norvegicus	218-222
14645220-4	2004	We found that endogenous Nedd4-2, but not Nedd4, negatively regulates ENaC in two epithelial cell lines (Fischer rat thyroid and H441); small interfering RNA (siRNA) against Nedd4-2 increased amiloride-sensitive Na+ current (compared with control siRNA), but Nedd4 siRNA did not.	Amiloride	192-201	NEDD4 like E3 ubiquitin protein ligase	Rattus norvegicus	25-32
14645220-4	2004	We found that endogenous Nedd4-2, but not Nedd4, negatively regulates ENaC in two epithelial cell lines (Fischer rat thyroid and H441); small interfering RNA (siRNA) against Nedd4-2 increased amiloride-sensitive Na+ current (compared with control siRNA), but Nedd4 siRNA did not.	Amiloride	192-201	NEDD4 E3 ubiquitin protein ligase	Rattus norvegicus	25-30
14576089-9	2004	These results are consistent with the hypothesis that a heterooligomer composed of alpha-, beta-, and gamma-ENaC may be the molecular basis of the native channels, which are responsible for amiloride-sensitive electrogenic Na+ absorption in rat rectal colon.	Amiloride	190-199	sodium channel epithelial 1 subunit gamma	Homo sapiens	102-112
14691048-6	2004	This phenomenon seems to be mediated by amiloride-sensitive Na(+)/H(+) exchange, and is inhibited by WEB2086 (a selective PAF receptor antagonist), genistein (a tyrosine kinase inhibitor), wortmannin and LY294002 (PI3K inhibitors), and PD98059 and UO126 (MEK inhibitors).	Amiloride	40-49	PCNA-associated factor	Bos taurus	122-125
14586636-4	2004	We used dissected lungs of Xenopus laevis in Ussing chambers to investigate the influence of prostaglandin E2 (PGE2) on the regulation of short-circuit current (ISC) and amiloride-sensitive sodium absorption (Iami).	Amiloride	170-179	prostaglandin E synthase 2 S homeolog	Xenopus laevis	111-115
14690446-0	2003	Glutamate 346 of human Na+-H+ exchanger NHE1 is crucial for modulating both the affinity for Na+ and the interaction with amiloride derivatives.	Amiloride	122-131	solute carrier family 9 member A1	Homo sapiens	40-44
16113405-6	2004	In many epithelial tissues, amiloride-sensitive epithelial sodium channels (ENaC) are formed from three subunit proteins designated alpha-ENaC, beta-ENaC, and gamma-ENaC.	Amiloride	28-37	sodium channel epithelial 1 subunit alpha	Homo sapiens	132-142
16113405-6	2004	In many epithelial tissues, amiloride-sensitive epithelial sodium channels (ENaC) are formed from three subunit proteins designated alpha-ENaC, beta-ENaC, and gamma-ENaC.	Amiloride	28-37	sodium channel epithelial 1 subunit beta	Homo sapiens	144-153
16113405-6	2004	In many epithelial tissues, amiloride-sensitive epithelial sodium channels (ENaC) are formed from three subunit proteins designated alpha-ENaC, beta-ENaC, and gamma-ENaC.	Amiloride	28-37	sodium channel epithelial 1 subunit gamma	Homo sapiens	159-169
12930837-5	2003	TGF-beta1 significantly reduced the amiloride-sensitive fraction of 22Na+ uptake and fluid transport across monolayers of both rat and human ATII cells.	Amiloride	36-45	transforming growth factor, beta 1	Rattus norvegicus	0-9
14644129-3	2003	By using in vitro cell invasion assay system, we evaluated the effects of amiloride and urinary trypsin inhibitor (UTI), which inhibit uPA and plasmin, respectively, on invasion by both cell lines.	Amiloride	74-83	plasminogen	Homo sapiens	143-150
14644129-5	2003	Amiloride and UTI significantly inhibited plasmin formation and the invasion of both cell lines (p<0.001).	Amiloride	0-9	plasminogen	Homo sapiens	42-49
14644129-7	2003	Thus, inhibitors of uPA and plasmin, such as amiloride and UTI, respectively, could be useful therapeutic tools with which to treat urothelial cancer.	Amiloride	45-54	plasminogen activator, urokinase	Homo sapiens	20-23
14644129-7	2003	Thus, inhibitors of uPA and plasmin, such as amiloride and UTI, respectively, could be useful therapeutic tools with which to treat urothelial cancer.	Amiloride	45-54	plasminogen	Homo sapiens	28-35
12928313-8	2003	Besides mutations Y279A and H282D, which had amiloride binding affinities similar to that of wild-type alpha-ENaC, all other mutations in this region caused changes in the amiloride binding affinity of the channels compared with the wild-type channel.	Amiloride	172-181	sodium channel epithelial 1 subunit alpha	Homo sapiens	103-113
14659506-6	2003	Mechanical hyperalgesia produced by repeated intramuscular acid injections is prevented by prior treatment of the muscle with the non-selective ASIC antagonist, amiloride, suggesting ASICs might be involved.	Amiloride	161-170	acid-sensing (proton-gated) ion channel 1	Mus musculus	144-148
12930837-8	2003	Consistent with the in vitro results, TGF-beta1 inhibited the amiloride-sensitive fraction of the distal airway epithelial fluid transport in an in vivo rat model at a dose that was not associated with any change in epithelial protein permeability.	Amiloride	62-71	transforming growth factor, beta 1	Rattus norvegicus	38-47
14554100-6	2003	In these cells, PCs induced an increase in [Ca2+]i that was inhibited by capsazepine, a TRPV1 antagonist, and/or by amiloride, an ASIC antagonist.	Amiloride	116-125	acid sensing ion channel subunit 1	Homo sapiens	130-134
12878488-3	2003	However, coupling ICAM-1 antibodies to nanoparticles creates multivalent ligands that enter cells via an amiloride-sensitive endocytic pathway that does not require clathrin or caveolin.	Amiloride	105-114	intercellular adhesion molecule 1	Homo sapiens	18-24
14556084-4	2003	Epicardial delivery of the amiloride analogue benzamil intended to specifically inhibit ENaC presumably located on cardiac sensory afferents indeed blunted the mechanosensitive (i. e., sympathoinhibition by intravenous volume loading [-32% and -42% in treated groups vs. -67% in controls; n = 7 each; p < 0.05]) as well as-though to a lesser extent-the 5-HT(3)-mediated chemosensitive cardiorenal reflex in vivo in a dose-dependent manner.	Amiloride	27-36	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	88-92
14559246-9	2003	Amiloride (uPA inhibitor) blocked the captopril-induced increase in EC survival, secondary sprouting, and invasion in Matrigel.	Amiloride	0-9	plasminogen activator, urokinase	Bos taurus	11-14
12837767-2	2003	Pharmacological inhibition of PLA2 with aristolochic acid induced a significant increase in amiloride-sensitive currents in Xenopus oocytes expressing ENaC.	Amiloride	92-101	phospholipase A2 group IB like L homeolog	Xenopus laevis	30-34
12876068-9	2003	Coexpression, in Fischer rat thyroid epithelia, of ENaC and Nedd4-2 cDNAs leads to a significant reduction in amiloride-sensitive currents, confirming a role in Na+ transport regulation.	Amiloride	110-119	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	51-55
12876068-9	2003	Coexpression, in Fischer rat thyroid epithelia, of ENaC and Nedd4-2 cDNAs leads to a significant reduction in amiloride-sensitive currents, confirming a role in Na+ transport regulation.	Amiloride	110-119	NEDD4 like E3 ubiquitin protein ligase	Rattus norvegicus	60-67
14511379-4	2003	This activity was completely inhibited by plasminogen activator inhibitor 1 and by amiloride, identifying the activity as urokinase plasminogen activator (uPA).	Amiloride	83-92	plasminogen activator, urokinase	Mus musculus	122-153
14511379-4	2003	This activity was completely inhibited by plasminogen activator inhibitor 1 and by amiloride, identifying the activity as urokinase plasminogen activator (uPA).	Amiloride	83-92	plasminogen activator, urokinase	Mus musculus	155-158
12957658-4	2003	The addition of 3-morpholinosydnominine (SIN-1, 1 mM), which generates both superoxide and nitric oxide anions, to amiloride-treated monolayers resulted in a transient increase of ISC to a peak value of 35 +/- 1.3 microA/cm2 (X +/- SE, n=14) within the next 30-60 min.	Amiloride	115-124	mitogen-activated protein kinase associated protein 1	Mus musculus	41-52
12746257-12	2003	Restoration of apical Na+ and/or removal of amiloride resulted in return of Isc to control levels over 2 h and coincided with return of apical beta-ENaC to control levels without change in apical alpha- or gamma-ENaC.	Amiloride	44-53	sodium channel epithelial 1 subunit beta	Homo sapiens	143-152
12914922-3	2003	These results together with our earlier observation that the amiloride analogues prevent labeling of the ND5 subunit of complex I with a fenpyroximate analogue suggest the involvement of ND5 in H(+) (Na(+)) translocation and no direct involvement of electron carriers in H(+) (Na(+)) translocation.	Amiloride	61-70	NADH dehydrogenase subunit 5	Bos taurus	105-108
12927657-2	2003	This study determined whether aspirin, which reverses platelet aggregation, or amiloride, a vasodilator, significantly reversed this rCBF hypoperfusion.	Amiloride	79-88	CCAAT/enhancer binding protein zeta	Rattus norvegicus	133-137
12927657-7	2003	Platelet aggregation after ADP showed no significant change during the month, but reduced rCBF significantly improved after 1-month treatment with amiloride compared with placebo and cocaine abstinence alone.	Amiloride	147-156	CCAAT/enhancer binding protein zeta	Rattus norvegicus	90-94
12914922-3	2003	These results together with our earlier observation that the amiloride analogues prevent labeling of the ND5 subunit of complex I with a fenpyroximate analogue suggest the involvement of ND5 in H(+) (Na(+)) translocation and no direct involvement of electron carriers in H(+) (Na(+)) translocation.	Amiloride	61-70	NADH dehydrogenase subunit 5	Bos taurus	187-190
12626340-4	2003	Addition of 10(-7) M ET-1 to the apical bath in the presence of amiloride increased Isc in cultured human bronchial epithelial cells studied in Ussing chambers.	Amiloride	64-73	endothelin 1	Homo sapiens	21-25
12848938-2	2003	Based on amiloride-dependent inhibition, the receptors that detect salt have been postulated to be DEG/ENaC channels.	Amiloride	9-18	deg	Drosophila melanogaster	99-102
12890576-3	2003	This effect of adrenaline was inhibited by amiloride or EIPA, indicating that adrenaline stimulated NHE 1.	Amiloride	43-52	solute carrier family 9 member A1	Homo sapiens	100-105
12872054-9	2003	Left ventricular myocytes from SHRs exhibited greater [Ca2+]i and pHi than those from SDRs; enalapril decreased [Ca2+]i more than amiloride, but amiloride decreased pHi more than enalapril.	Amiloride	145-154	glucose-6-phosphate isomerase	Rattus norvegicus	165-168
12742636-6	2003	An antibody against t-PA inhibited the former, whereas the latter was inhibited by amiloride.	Amiloride	83-92	plasminogen activator, tissue type	Rattus norvegicus	20-24
12684793-4	2003	To test the hypothesis that the application of aldosterone results in greater activity of the apical Na(+)/H(+) exchanger-3 (NHE3), we investigated the effect of aldosterone on amiloride-sensitive, proximal tubular volume reabsorption and proximal tubular NHE3 abundance in adrenalectomized rats.	Amiloride	177-186	solute carrier family 9 member A3	Rattus norvegicus	125-129
12831348-4	2003	As the benefits of NHE1 inhibitors (e.g., amiloride, cariporide) in models of myocardial infarction are usually much greater when used as pretreatment, rather than during or after ischaemia, it is probably not surprising that clinical trials with cariporide in ischaemia have shown little shortterm benefit.	Amiloride	42-51	solute carrier family 9 member A1	Homo sapiens	19-23
12813409-11	2003	Urokinase inhibitor, amiloride, blocked uPA activity in retinal extracts.	Amiloride	21-30	plasminogen activator, urokinase	Mus musculus	40-43
12765964-4	2003	This hypothesis, however, has been long hampered by the total insensitivity of SLC to amiloride, which is an intrinsic inhibitor of the first isoform of NHE, the only NHE isoform detected in human erythrocytes.	Amiloride	86-95	solute carrier family 9 member C1	Homo sapiens	153-156
12765964-4	2003	This hypothesis, however, has been long hampered by the total insensitivity of SLC to amiloride, which is an intrinsic inhibitor of the first isoform of NHE, the only NHE isoform detected in human erythrocytes.	Amiloride	86-95	solute carrier family 9 member C1	Homo sapiens	167-170
12765964-5	2003	We describe here the identification in human reticulocytes and erythrocytes of an alternative splicing of NHE lacking the amiloride binding site.	Amiloride	122-131	solute carrier family 9 member C1	Homo sapiens	106-109
12832126-5	2003	Beside its ability to inhibit a conductive Na(+) channel and the Na(+)/Ca(++) exchanger, amiloride was the first drug described as NHE inhibitor.	Amiloride	89-98	solute carrier family 8 member A1	Homo sapiens	65-87
12832126-5	2003	Beside its ability to inhibit a conductive Na(+) channel and the Na(+)/Ca(++) exchanger, amiloride was the first drug described as NHE inhibitor.	Amiloride	89-98	solute carrier family 9 member C1	Homo sapiens	131-134
12832126-8	2003	The replacement of the pyrazine ring of amiloride by a pyridine ring or by a phenyl increased the potency and the NHE selectivity.	Amiloride	40-49	solute carrier family 9 member C1	Homo sapiens	114-117
12736332-6	2003	Oocyte electrophysiology demonstrated that the ASIC2a/ASIC2b channel generated maximal inward currents at a pH of < or =2.0, which is in agreement with the in vivo pH sensitivity of rat taste cells, and that the amiloride sensitivity of the heteromer decreased with decreasing pH and was almost completely abolished at a pH of 2.0.	Amiloride	215-224	acid sensing ion channel subunit 2	Rattus norvegicus	47-52
12650878-7	2003	NHE inhibition (amiloride 1 mM) in T3 hearts lead to: (1) delayed and lower Na+i accumulation by 35+/-5%; (2) faster and greater acidification (pH(i) 6.45+/-0.15, P<0.05); (3) delayed ATP degradation; and (4) improved heart function during recovery.	Amiloride	16-25	solute carrier family 9 member C1	Homo sapiens	0-3
12584187-8	2003	Thus, syntaxin 1A cannot inhibit Na(+) permeability in the absence of adequate plasma membrane ASIC2 expression, accounting for the observed functional expression of amiloride-sensitive currents in high grade glioma cells.	Amiloride	166-175	syntaxin 1A	Homo sapiens	6-17
12676384-1	2003	We investigated the possible role of amiloride-sensitive ion channels of the ENaC/DEGenerin superfamily in the activation of trigeminal nociceptive neurons elicited by noxious chemical stimulation of the oral mucosa using two methodologies, single-unit recording and c-fos immunohistochemistry.	Amiloride	37-46	acid sensing ion channel subunit 2	Rattus norvegicus	82-91
12453872-4	2003	Staurosporine- and hypertonic NaCl-induced RTC apoptosis was associated with cell shrinkage and diminished cytosolic pH, and apoptosis was potentiated by amiloride analogs, suggesting NHE1 activity opposes apoptosis.	Amiloride	154-163	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	184-188
12660316-7	2003	Furthermore, Na absorption in ARPKD cells was partially inhibited by 100 micro M apical amiloride or 1 mM basolateral but not apical ouabain.	Amiloride	88-97	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	Homo sapiens	30-35
12660316-9	2003	These results suggest that, despite the presence of apical Na/K-ATPase, ARPKD cyst-lining cells absorb Na by a pathway that is modestly amiloride-sensitive.	Amiloride	136-145	PKHD1 ciliary IPT domain containing fibrocystin/polyductin	Homo sapiens	72-77
12682798-1	2003	Both stimulation of purinergic receptors by ATP and activation of the cystic fibrosis transmembrane conductance regulator (CFTR) inhibit amiloride-sensitive Na+ transport and activate Cl- secretion.	Amiloride	137-146	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	70-121
12682798-1	2003	Both stimulation of purinergic receptors by ATP and activation of the cystic fibrosis transmembrane conductance regulator (CFTR) inhibit amiloride-sensitive Na+ transport and activate Cl- secretion.	Amiloride	137-146	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	123-127
12682798-4	2003	Stimulation of purinergic receptors by ATP/UTP or activation of CFTR by IBMX and forskolin inhibited amiloride-sensitive transport in mouse trachea and colon, respectively, by a mechanism that was Cl- dependent.	Amiloride	101-110	cystic fibrosis transmembrane conductance regulator	Mus musculus	64-68
12926549-3	2003	It was demonstrated that amiloride used for incubation of the caecum fragments lowered by some 24% the value of PD and by 50% the value of dPD.	Amiloride	25-34	dachs	Drosophila melanogaster	112-114
12632189-5	2003	Dual-electrode voltage-clamp experiments in Xenopus laevis oocytes expressing alpha,ss,gamma-ENaC with or without SGK1, SGK2 or SGK3 revealed a stimulatory effect of all three kinases on the amiloride-sensitive current (I(Na)).	Amiloride	191-200	sodium channel, non voltage gated 1 gamma subunit S homeolog	Xenopus laevis	87-97
12926549-3	2003	It was demonstrated that amiloride used for incubation of the caecum fragments lowered by some 24% the value of PD and by 50% the value of dPD.	Amiloride	25-34	dachs	Drosophila melanogaster	139-142
12493726-6	2003	The Na(+)-dependent rate of pH(i) recovery was also inhibited by amiloride, indicating H(+) extrusion through NHEs; however, the amiloride sensitivity of the apical membrane was less than that of the basolateral membrane, suggesting the involvement of different types of NHEs in the two membranes.	Amiloride	65-74	glucose-6-phosphate isomerase 1	Mus musculus	28-33
12639498-7	2003	In TG neurons in which VRs were blocked or desensitized, PCs induced an amiloride-inhibitable inward current having the characteristics of ASIC-mediated currents.	Amiloride	72-81	acid sensing ion channel subunit 1	Homo sapiens	139-143
12388075-3	2003	The effect of SGK expression on ENaC activity was monitored by measuring transepithelial amiloride-sensitive short-circuit current (I(sc)) of transfected A6 cell lines.	Amiloride	89-98	serum/glucocorticoid regulated kinase 1	Homo sapiens	14-17
12388407-0	2003	Epidermal growth factor inhibits amiloride-sensitive sodium absorption in renal collecting duct cells.	Amiloride	33-42	epidermal growth factor	Mus musculus	0-23
12388407-2	2003	Approximately 90% of the unstimulated short-circuit current (15 +/- 1 microA/cm(2), n = 10) across conditionally immortalized murine collecting duct epithelial cells (mCT1) is amiloride sensitive and is likely mediated by apical epithelial Na(+) channels.	Amiloride	176-185	cardiotrophin 1	Mus musculus	167-171
12388407-3	2003	Chronic exposure (24 h) of the epithelial monolayers to either EGF (50 ng/ml) or transforming growth factor-alpha (TGF-alpha; 20 ng/ml) reduced amiloride-sensitive short-circuit current by >60%.	Amiloride	144-153	transforming growth factor alpha	Mus musculus	81-113
12388407-3	2003	Chronic exposure (24 h) of the epithelial monolayers to either EGF (50 ng/ml) or transforming growth factor-alpha (TGF-alpha; 20 ng/ml) reduced amiloride-sensitive short-circuit current by >60%.	Amiloride	144-153	transforming growth factor alpha	Mus musculus	115-124
12388407-7	2003	Similarly, pretreatment of mCT1 monolayers with PD-98059 prevented the EGF- and PMA-induced inhibition of amiloride-sensitive Na(+) absorption.	Amiloride	106-115	cardiotrophin 1	Mus musculus	27-31
12388407-8	2003	The results of these studies demonstrate that amiloride-sensitive Na(+) absorption by renal collecting duct cells is regulated by the ERK pathway.	Amiloride	46-55	mitogen-activated protein kinase 1	Mus musculus	134-137
12493726-6	2003	The Na(+)-dependent rate of pH(i) recovery was also inhibited by amiloride, indicating H(+) extrusion through NHEs; however, the amiloride sensitivity of the apical membrane was less than that of the basolateral membrane, suggesting the involvement of different types of NHEs in the two membranes.	Amiloride	129-138	glucose-6-phosphate isomerase 1	Mus musculus	28-33
14646359-4	2003	Amiloride was well tolerated by CD1 female mice, but induced severe hyperkalemia in male mice, where it was also associated with a high rate of mortality.	Amiloride	0-9	CD1 antigen complex	Mus musculus	32-35
14646359-6	2003	Histopathological analysis of kidneys from CD1 male mice treated with amiloride revealed alterations at the proximal and distal tubule level.	Amiloride	70-79	CD1 antigen complex	Mus musculus	43-46
12548398-4	2003	We could confirm previous reports that in oocytes co-expressing ENaC and CFTR the amiloride-sensitive current was reduced during cAMP-mediated stimulation of CFTR.	Amiloride	82-91	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	73-77
12548398-4	2003	We could confirm previous reports that in oocytes co-expressing ENaC and CFTR the amiloride-sensitive current was reduced during cAMP-mediated stimulation of CFTR.	Amiloride	82-91	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	158-162
12386156-6	2002	Oocytes co-injected with both G551D-CFTR and ENaC expressed an amiloride-sensitive whole cell current that was similar to that observed before and after G551D-CFTR activation with forskolin/isobutylmethylxanthine.	Amiloride	63-72	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	36-40
12509480-10	2003	Blockage or desensitization of ASIC1 with amiloride or pH 6.7, respectively, did not modify postsynaptic currents.	Amiloride	42-51	acid sensing ion channel subunit 1	Homo sapiens	31-36
12386156-6	2002	Oocytes co-injected with both G551D-CFTR and ENaC expressed an amiloride-sensitive whole cell current that was similar to that observed before and after G551D-CFTR activation with forskolin/isobutylmethylxanthine.	Amiloride	63-72	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	45-49
12413883-8	2002	Using our previously described microtube technique to assess in vivo cell migration, we showed that uPA is implicated in the in vivo migration of C(2)C(12) cells since this migration was abrogated in the presence of aprotinin (a general serine protease inhibitor) or amiloride (a uPA-specific inhibitor).	Amiloride	267-276	plasminogen activator, urokinase	Mus musculus	100-103
12466372-8	2002	The activity (amiloride-sensitive Na(+) uptake) of NHE in MVM from IUGR preterm placentas was reduced by 48% (P < 0.05, n = 6).	Amiloride	14-23	solute carrier family 9 member C1	Homo sapiens	51-54
12435797-5	2002	In cultured mouse mpkCCD(cl4) principal cells, 17OHP and 20OHP also prevented the aldosterone-stimulated amiloride-sensitive component of the short-circuit current (Ams I(sc)), reflecting Na(+) absorption mediated by the epithelial Na(+) channel (ENaC).	Amiloride	105-114	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	221-245
12435797-5	2002	In cultured mouse mpkCCD(cl4) principal cells, 17OHP and 20OHP also prevented the aldosterone-stimulated amiloride-sensitive component of the short-circuit current (Ams I(sc)), reflecting Na(+) absorption mediated by the epithelial Na(+) channel (ENaC).	Amiloride	105-114	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	247-251
12390871-5	2002	The MIA-resistant component was inhibited by 2 mM amiloride and enhanced by external K+ and by 4,4"-diisothiocyanostilbene-2,2"-disulfonate, suggesting NHE4 activity.	Amiloride	50-59	solute carrier family 9 (sodium/hydrogen exchanger), member 4	Mus musculus	152-156
12478294-7	2002	MEC-6 increases amiloride-sensitive Na+ currents produced by MEC-4(d)/MEC-10(d) by approximately 30-fold, and functions synergistically with MEC-2 (a stomatin-like protein that regulates MEC-4(d)/MEC-10(d) channel activity) to increase the currents by 200-fold.	Amiloride	16-25	Mechanosensory abnormality protein 6	Caenorhabditis elegans	0-5
12478294-7	2002	MEC-6 increases amiloride-sensitive Na+ currents produced by MEC-4(d)/MEC-10(d) by approximately 30-fold, and functions synergistically with MEC-2 (a stomatin-like protein that regulates MEC-4(d)/MEC-10(d) channel activity) to increase the currents by 200-fold.	Amiloride	16-25	Degenerin mec-4	Caenorhabditis elegans	61-66
12478294-7	2002	MEC-6 increases amiloride-sensitive Na+ currents produced by MEC-4(d)/MEC-10(d) by approximately 30-fold, and functions synergistically with MEC-2 (a stomatin-like protein that regulates MEC-4(d)/MEC-10(d) channel activity) to increase the currents by 200-fold.	Amiloride	16-25	Degenerin mec-10	Caenorhabditis elegans	70-76
12225976-7	2002	Similarly, overnight treatment with an uncharged amiloride analog (CDPC), a procedure that through feedback regulation causes a stimulation of Na(+) transport, also decreased PKCalpha levels.	Amiloride	49-58	protein kinase C alpha	Homo sapiens	175-183
12381774-6	2002	In many epithelial tissues, amiloride-sensitive epithelial sodium channels (ENaC) are formed from three subunit proteins, designated alpha-, beta-, and gamma-ENaC.	Amiloride	28-37	sodium channel epithelial 1 subunit gamma	Homo sapiens	152-162
12225981-0	2002	Amiloride-sensitive sodium current in everted Ambystoma initial collecting tubule: short-term insulin effects.	Amiloride	0-9	insulin	Homo sapiens	94-101
12393854-5	2002	In our psychophysical experiments, direct infusion of acidic solutions (pH > or = 6.0) into human skin caused localized pain, which was blocked by amiloride, an inhibitor of ASICs, but not by capsazepine, an inhibitor of VR1.	Amiloride	150-159	transient receptor potential cation channel subfamily V member 1	Homo sapiens	224-227
12396248-5	2002	PMA inhibited the mRNA expression of all 3 ENaC subunits (alpha-ENaC: 56.0% +/- 12.1%; beta-ENaC: 62.6% +/- 15.9%; gamma-ENaC: 68.5% +/- 10.6%, respectively) and amiloride-sensitive current (control = 7.0 +/- 1.5 microA/cm(2); PMA = 1.7 +/- 0.9 microA/cm(2)) significantly at 24 hours.	Amiloride	162-171	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	43-47
12297528-5	2002	The increase in the [Ca(2+)](i) was due to Ca(2+) influx since it was abolished in the absence of extracellular Ca(2+), and the increase was mediated by the Na(+)/Ca(2+) exchanger since it was blocked by the application of amiloride or bepridil, inhibitors of Na(+)/Ca(2+) exchange.	Amiloride	223-232	solute carrier family 8 member A1	Homo sapiens	157-179
12393854-8	2002	Amiloride itself neither blocked capsaicin-evoked localized pain in human skin nor inhibited proton-induced currents in VR1-expressing Xenopus oocytes.	Amiloride	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	120-123
12225848-1	2002	Both purinergic stimulation and activation of cystic fibrosis transmembrane conductance regulator (CFTR) increases Cl(-) secretion and inhibit amiloride-sensitive Na(+) transport.	Amiloride	143-152	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	46-97
12225848-1	2002	Both purinergic stimulation and activation of cystic fibrosis transmembrane conductance regulator (CFTR) increases Cl(-) secretion and inhibit amiloride-sensitive Na(+) transport.	Amiloride	143-152	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	99-103
12225848-5	2002	Inhibition of amiloride-sensitive transport by both CFTR and extracellular nucleotides was observed in colon and trachea.	Amiloride	14-23	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	52-56
12235489-3	2002	Tracheas of both normal and CFTR (-/-) mice showed a dominant amiloride-sensitive Na+ absorption under both, control conditions and after cAMP-dependent stimulation.	Amiloride	62-71	cystic fibrosis transmembrane conductance regulator	Mus musculus	28-32
12107048-7	2002	NHE inhibition decreased also the IL-1beta-induced HUVEC inflammatory response, because amiloride suppressed IL-1beta-induced E-selectin expression on HUVECs.	Amiloride	88-97	interleukin 1 beta	Homo sapiens	109-117
12183060-8	2002	Amiloride, a specific inhibitor of urokinase, inhibited production of the 31-kDa alpha-actinin fragment by HL-60 cell lysates.	Amiloride	0-9	actinin alpha 1	Homo sapiens	81-94
12107048-7	2002	NHE inhibition decreased also the IL-1beta-induced HUVEC inflammatory response, because amiloride suppressed IL-1beta-induced E-selectin expression on HUVECs.	Amiloride	88-97	selectin E	Homo sapiens	126-136
12107048-4	2002	NHE inhibition using amiloride, 5-(N-ethyl-N-isopropyl)-amiloride, and 5-(N-methyl-N-isobutyl)amiloride as well as the non-amiloride NHE inhibitors cimetidine, clonidine, and harmaline suppressed endotoxin-induced IL-8 and monocyte chemoattractant protein (MCP)-1 production by human umbilical endothelial vein cells (HUVECs).	Amiloride	21-30	solute carrier family 9 member C1	Homo sapiens	0-3
12107048-5	2002	The suppressive effect of amiloride on endotoxin-induced IL-8 production was associated with a decreased accumulation of IL-8 mRNA.	Amiloride	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
12177237-8	2002	CFTR functionality was assessed by analyzing the Cl(-) secretion after amiloride and forskolin perfusion.	Amiloride	71-80	CF transmembrane conductance regulator	Homo sapiens	0-4
12107048-5	2002	The suppressive effect of amiloride on endotoxin-induced IL-8 production was associated with a decreased accumulation of IL-8 mRNA.	Amiloride	26-35	C-X-C motif chemokine ligand 8	Homo sapiens	121-125
12055080-3	2002	We next sought to demonstrate physiological evidence for an amiloride-sensitive current in Muller glia, which, on the basis of a previous study, are thought to express alpha-ENaC (Golestaneh N, de Kozak Y, Klein C, and Mirshahi M. Glia 33: 160-168, 2001).	Amiloride	60-69	amiloride-sensitive sodium channel subunit alpha	Oryctolagus cuniculus	168-178
12081571-9	2002	However, further inhibition of Na+/H+ exchange with amiloride greatly magnified CsA toxicity and GLUT1 gene transcription.	Amiloride	52-61	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	80-83
12065299-5	2002	In human gut epithelial cells, NHE inhibition using a variety of agents, including amiloride, 5-(N-methyl-N-isobutyl)amiloride, 5-(N-ethyl-N-isopropyl)- amiloride, harmaline, clonidine, and cimetidine, suppressed interleukin-8 (IL-8) production.	Amiloride	83-92	solute carrier family 9 member C1	Homo sapiens	31-34
12084777-0	2002	cAMP increases density of ENaC subunits in the apical membrane of MDCK cells in direct proportion to amiloride-sensitive Na(+) transport.	Amiloride	101-110	cathelicidin antimicrobial peptide	Canis lupus familiaris	0-4
12070711-5	2002	Both sodium butyrate and amiloride inhibited the uPAR mRNA levels induced by IFN-alpha or IFN-gamma.	Amiloride	25-34	plasminogen activator, urokinase receptor	Homo sapiens	49-53
12070711-5	2002	Both sodium butyrate and amiloride inhibited the uPAR mRNA levels induced by IFN-alpha or IFN-gamma.	Amiloride	25-34	interferon alpha 1	Homo sapiens	77-86
12070711-5	2002	Both sodium butyrate and amiloride inhibited the uPAR mRNA levels induced by IFN-alpha or IFN-gamma.	Amiloride	25-34	interferon gamma	Homo sapiens	90-99
12030906-12	2002	CONCLUSIONS: The observed differences in RBC Na+,K+-ATPase activity and nasal PD response to amiloride between the two pairs of twins support the contention of different basic pathogenic mechanisms in the two forms of PHA1.	Amiloride	93-102	sodium channel epithelial 1 subunit gamma	Homo sapiens	218-222
12105131-7	2002	Amiloride alone (10 mg BID) controlled blood pressure effectively to the same level (140/91+/-4/2 mm Hg).	Amiloride	0-9	BH3 interacting domain death agonist	Homo sapiens	23-26
12105131-10	2002	These results demonstrate that 10 mg BID amiloride is effective in controlling blood pressure in hypertensive individuals of African origin who have the T594M polymorphism.	Amiloride	41-50	BH3 interacting domain death agonist	Homo sapiens	37-40
12037186-8	2002	H+-gated currents in DRASIC null neurons showed a decreased sensitivity to pH and an enhanced sensitivity to amiloride.	Amiloride	109-118	acid-sensing (proton-gated) ion channel 3	Mus musculus	21-27
11937337-1	2002	Pyridine and benzene bioisosteres of amiloride were synthesized and evaluated for their inhibitory potency against the sodium-hydrogen exchanger (NHE) involved in intracellular pH regulation.	Amiloride	37-46	solute carrier family 9 member C1	Homo sapiens	146-149
11937337-4	2002	The results indicated that several benzene derivatives and compounds bearing an carbonylguanidine moiety in the meta position of the pyridine nitrogen were much more potent than amiloride (PSA:IC(50)=43.5 microM; UIA:IC(50)=100.1 microM), but less than EIPA, a pyrazine NHE inhibitor (PSA:IC(50)=0.08 microM; UIA:IC(50)=0.5 microM).	Amiloride	178-187	solute carrier family 9 member C1	Homo sapiens	270-273
11937337-6	2002	Our investigations demonstrated that the replacement of the pyrazine ring of amiloride by a pyridine or a phenyl ring improved the NHE inhibitory potency (phenyl >pyridine >pyrazine).	Amiloride	77-86	solute carrier family 9 member C1	Homo sapiens	131-134
11960774-9	2002	We conclude that 1) NHE3 is the dominant NHE involved in small intestinal Na(+) absorption; 2) an amiloride-sensitive Na(+) transporter partially compensates for Na(+) absorption in NHE3(-) jejunum; 3) cAMP(i) stimulation abolishes net Na(+) absorption in NHE(+), NHE2(-), and NHE3(-) jejunum; and 4) electroneutral Cl(-) absorption is not directly dependent on either NHE2 or NHE3.	Amiloride	98-107	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	20-24
11960774-9	2002	We conclude that 1) NHE3 is the dominant NHE involved in small intestinal Na(+) absorption; 2) an amiloride-sensitive Na(+) transporter partially compensates for Na(+) absorption in NHE3(-) jejunum; 3) cAMP(i) stimulation abolishes net Na(+) absorption in NHE(+), NHE2(-), and NHE3(-) jejunum; and 4) electroneutral Cl(-) absorption is not directly dependent on either NHE2 or NHE3.	Amiloride	98-107	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	182-186
11960774-9	2002	We conclude that 1) NHE3 is the dominant NHE involved in small intestinal Na(+) absorption; 2) an amiloride-sensitive Na(+) transporter partially compensates for Na(+) absorption in NHE3(-) jejunum; 3) cAMP(i) stimulation abolishes net Na(+) absorption in NHE(+), NHE2(-), and NHE3(-) jejunum; and 4) electroneutral Cl(-) absorption is not directly dependent on either NHE2 or NHE3.	Amiloride	98-107	solute carrier family 9 (sodium/hydrogen exchanger), member 2	Mus musculus	264-268
11960774-9	2002	We conclude that 1) NHE3 is the dominant NHE involved in small intestinal Na(+) absorption; 2) an amiloride-sensitive Na(+) transporter partially compensates for Na(+) absorption in NHE3(-) jejunum; 3) cAMP(i) stimulation abolishes net Na(+) absorption in NHE(+), NHE2(-), and NHE3(-) jejunum; and 4) electroneutral Cl(-) absorption is not directly dependent on either NHE2 or NHE3.	Amiloride	98-107	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	277-299
11960774-9	2002	We conclude that 1) NHE3 is the dominant NHE involved in small intestinal Na(+) absorption; 2) an amiloride-sensitive Na(+) transporter partially compensates for Na(+) absorption in NHE3(-) jejunum; 3) cAMP(i) stimulation abolishes net Na(+) absorption in NHE(+), NHE2(-), and NHE3(-) jejunum; and 4) electroneutral Cl(-) absorption is not directly dependent on either NHE2 or NHE3.	Amiloride	98-107	solute carrier family 9 (sodium/hydrogen exchanger), member 2	Mus musculus	369-373
11960774-9	2002	We conclude that 1) NHE3 is the dominant NHE involved in small intestinal Na(+) absorption; 2) an amiloride-sensitive Na(+) transporter partially compensates for Na(+) absorption in NHE3(-) jejunum; 3) cAMP(i) stimulation abolishes net Na(+) absorption in NHE(+), NHE2(-), and NHE3(-) jejunum; and 4) electroneutral Cl(-) absorption is not directly dependent on either NHE2 or NHE3.	Amiloride	98-107	solute carrier family 9 (sodium/hydrogen exchanger), member 3	Mus musculus	182-186
11996897-1	2002	A beta-adrenergic agonist (beta-agonist), terbutaline, stimulated amiloride-sensitive Na(+) absorption in fetal rat alveolar type II epithelium, contributing to the clearance of lung fluid.	Amiloride	66-75	amyloid beta precursor protein	Rattus norvegicus	0-6
12398159-5	2002	Capsaicin decreased PD and reaction to mechanical stimulation in trachea incubated in Ringer solution supplemented with amiloride.	Amiloride	120-129	dachs	Drosophila melanogaster	20-22
18968580-3	2002	Amiloride was transitorily retained on cationic exchanger gel Sephadex SP-C25 placed in the detection area into the cell.	Amiloride	0-9	SPC25 component of NDC80 kinetochore complex	Homo sapiens	71-77
11920577-2	2002	The specific and dose-dependent induction of IFN-gamma release and cytotoxicity in CTL by metabolically active DC did not depend on antigenic peptides contaminating the particles, was cytochalasin D resistant, independent of the maturation state of DC, and blocked by primaquine, amiloride and NH(4)Cl (indicating involvement of acid proteolysis).	Amiloride	280-289	interferon gamma	Mus musculus	45-54
11809744-5	2002	By two-electrode voltage clamp recordings, we demonstrated that PIP(2) and PIP(3) significantly increased amiloride-sensitive current in Xenopus oocytes injected with cRNAs of rat alpha-, beta-, and gamma-ENaC.	Amiloride	106-115	prolactin induced protein	Rattus norvegicus	64-67
11809744-5	2002	By two-electrode voltage clamp recordings, we demonstrated that PIP(2) and PIP(3) significantly increased amiloride-sensitive current in Xenopus oocytes injected with cRNAs of rat alpha-, beta-, and gamma-ENaC.	Amiloride	106-115	prolactin induced protein	Rattus norvegicus	75-78
11809744-5	2002	By two-electrode voltage clamp recordings, we demonstrated that PIP(2) and PIP(3) significantly increased amiloride-sensitive current in Xenopus oocytes injected with cRNAs of rat alpha-, beta-, and gamma-ENaC.	Amiloride	106-115	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	199-209
12046895-0	2002	Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu.	Amiloride	0-9	Vpu	Human immunodeficiency virus 1	120-123
11792627-3	2002	Ussing chamber studies indicated that 48 h pretreatment with IL-13 or IL-4 significantly reduced the basal short-circuit current (I(sc)) and inhibited the amiloride-sensitive current by >98%.	Amiloride	155-164	interleukin 13	Homo sapiens	61-66
12046895-3	2002	Here we report that the Vpu ion channel is inhibited by the amiloride derivatives 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride but not by amiloride itself, nor by amantadine.	Amiloride	60-69	Vpu	Human immunodeficiency virus 1	24-27
12046895-3	2002	Here we report that the Vpu ion channel is inhibited by the amiloride derivatives 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride but not by amiloride itself, nor by amantadine.	Amiloride	103-112	Vpu	Human immunodeficiency virus 1	24-27
12046895-5	2002	These results confirm the link between Vpu ion channel activity and the budding process and also suggest that amiloride derivatives might have useful anti-HIV-1 properties.	Amiloride	110-119	Vpu	Human immunodeficiency virus 1	39-42
11951376-3	2002	Cellular acid then exits the cell via an amiloride-inhibitable process, presumably sodium-proton exchange (NHE1).	Amiloride	41-50	solute carrier family 9 member A1	Homo sapiens	107-111
11792627-3	2002	Ussing chamber studies indicated that 48 h pretreatment with IL-13 or IL-4 significantly reduced the basal short-circuit current (I(sc)) and inhibited the amiloride-sensitive current by >98%.	Amiloride	155-164	interleukin 4	Homo sapiens	70-74
11792627-7	2002	The results indicate that IL-13 converts the human bronchial epithelium from an absorptive to a secretory phenotype that is the result of loss of amiloride-sensitive current and an increase in a DIDS-sensitive apical anion conductance.	Amiloride	146-155	interleukin 13	Homo sapiens	26-31
11790817-6	2002	This was almost abolished by removal of extracellular Na(+) and by amiloride (1 mM), consistent with the activity of a Na(+)-H(+) exchanger (NHE).	Amiloride	67-76	solute carrier family 9 member C1	Homo sapiens	141-144
12122578-12	2002	Although both CPZ and amiloride significantly reduced IL-6 release for all PM, the degree of inhibition was less for the PM-exposed DRG relative to BEAS-2B cells.	Amiloride	22-31	interleukin 6	Homo sapiens	54-58
11828000-8	2002	These findings, together with our previous report that prostasin activates the amiloride-sensitive Na currents through ENaC, demonstrate that prostasin regulates Na balance in vivo by virtue of its heightened expression in the presence of aldosterone.	Amiloride	79-88	serine protease 8	Homo sapiens	55-64
11828000-8	2002	These findings, together with our previous report that prostasin activates the amiloride-sensitive Na currents through ENaC, demonstrate that prostasin regulates Na balance in vivo by virtue of its heightened expression in the presence of aldosterone.	Amiloride	79-88	serine protease 8	Homo sapiens	142-151
12047811-7	2002	The BFP-induced I(SC) was insensitive to the Na(+) channel blocker, amiloride, but partially inhibited by the Cl(-) channel blocker, DIDS (100 microM), and completely blocked by DPC (2 mM) or glibenclamide (1 mM) with a significant reduction in the apical conductance.	Amiloride	68-77	ring finger protein 112	Homo sapiens	4-7
11707435-7	2002	Ion exchange by AtNHX1 was inhibited 70% by the amiloride analog ethylisopropyl-amiloride.	Amiloride	48-57	Na+/H+ exchanger 1	Arabidopsis thaliana	16-22
12139396-2	2002	This amiloride-sensitive Na+ current is subject to feedback regulation by intracellular Na+ and we have previously demonstrated that this regulation is mediated by an ubiquitin-protein ligase, which we identified as Nedd4.	Amiloride	5-14	neural precursor cell expressed, developmentally down-regulated 4	Mus musculus	216-221
11774284-7	2002	Amiloride, an inhibitor of the Na+/H+ antiporter downstream of ROCK, suppressed cell motility and correspondingly paxillin tyrosine-phosphorylation at both Y31 and Y118.	Amiloride	0-9	paxillin	Rattus norvegicus	114-122
11751211-0	2002	Amiloride blockades lipopolysaccharide-induced proinflammatory cytokine biosynthesis in an IkappaB-alpha/NF-kappaB-dependent mechanism.	Amiloride	0-9	NFKB inhibitor alpha	Homo sapiens	91-104
11751211-5	2002	Exposure of alveolar epithelial cells to amiloride or its analog, 5-(N,N-hexamethylene)-amiloride (HMA), reduced, in a dose-dependent manner, lipopolysaccharide (LPS)-induced secretion of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha.	Amiloride	41-50	interleukin 1 beta	Homo sapiens	188-210
11751211-5	2002	Exposure of alveolar epithelial cells to amiloride or its analog, 5-(N,N-hexamethylene)-amiloride (HMA), reduced, in a dose-dependent manner, lipopolysaccharide (LPS)-induced secretion of interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha.	Amiloride	41-50	tumor necrosis factor	Homo sapiens	215-248
11751211-8	2002	Amiloride and HMA suppressed the phosphorylation of IkappaB-alpha mediated by LPS, thereby allowing its cytosolic accumulation.	Amiloride	0-9	NFKB inhibitor alpha	Homo sapiens	52-65
11751211-11	2002	Immunoneutralization of endogenous IL-10 reversed the inhibitory effect of amiloride on proinflammatory cytokines and restored the DNA-binding activity of NF-kappaB.	Amiloride	75-84	interleukin 10	Homo sapiens	35-40
11835393-5	2002	Plasminogen-dependent [3H]-collagen IV degradation was inhibited by inhibitor of uPA (amiloride) and MMP (phenanthroline) and by antibodies against uPA or MMP-9 or alphavbeta6 integrin, indicating the involvement of alphavbeta6 integrin, uPA and MMP-9 in the process.	Amiloride	86-95	plasminogen activator, urokinase	Homo sapiens	81-84
12404882-0	2002	Volume independent stimulation of renin secretion by a single dose of amiloride in man.	Amiloride	70-79	renin	Homo sapiens	34-39
12404882-2	2002	There is evidence that amiloride (CAS 17440-83-4) has a stimulatory effect on the renin secretion but it is still in question whether this is volume and/or sodium independent.	Amiloride	23-32	renin	Homo sapiens	82-87
12404882-3	2002	The purpose of this study was to investigate whether a single dose of amiloride has a direct stimulatory effect on the renin secretion in humans independent of its diuretic effect.	Amiloride	70-79	renin	Homo sapiens	119-124
12404882-7	2002	There was a decrease in plasma renin activities and plasma aldosterone concentrations after amiloride and placebo administration, but the plasma renin activity after amiloride was significantly higher compared with placebo.	Amiloride	92-101	renin	Homo sapiens	31-36
12404882-7	2002	There was a decrease in plasma renin activities and plasma aldosterone concentrations after amiloride and placebo administration, but the plasma renin activity after amiloride was significantly higher compared with placebo.	Amiloride	166-175	renin	Homo sapiens	145-150
12404882-11	2002	The present study provides evidence that amiloride induces renin secretion by direct mechanisms in man, which might go along with augmented aldosterone secretion.	Amiloride	41-50	renin	Homo sapiens	59-64
11902254-10	2002	All pharmacologic agents reduced the burn-mediated Ca2+/Na+ accumulation in cardiomyocytes and ablated burn-mediated tumor necrosis factor-alpha secretion by myocytes; in contrast, dantrolene and amiloride provided significantly greater cardioprotection than pharmacologic agents that specifically targeted Ca2+ slow channels (diltiazem and amlodipine).	Amiloride	196-205	tumor necrosis factor	Rattus norvegicus	117-144
11991662-2	2002	Amiloride, a competitive inhibitor of uPA, can inhibit endothelial cell (EC) outgrowth during angiogenesis.	Amiloride	0-9	plasminogen activator, urokinase	Homo sapiens	38-41
11991662-3	2002	To address the question of whether amiloride blocked angiogenesis by inhibiting uPA, we undertook a study of uPA expression in sprouting EC in vitro and the effects of amiloride on both enzymatic and morphogenetic activity.	Amiloride	35-44	plasminogen activator, urokinase	Homo sapiens	80-83
11991662-4	2002	As expected, amiloride inhibited soluble uPA (suPA) with an IC(50) of 45-85 microm, however, receptor-bound uPA (rbuPA) from the sprouting EC was insensitive to amiloride.	Amiloride	13-22	plasminogen activator, urokinase	Homo sapiens	41-44
11991662-4	2002	As expected, amiloride inhibited soluble uPA (suPA) with an IC(50) of 45-85 microm, however, receptor-bound uPA (rbuPA) from the sprouting EC was insensitive to amiloride.	Amiloride	13-22	plasminogen activator, urokinase	Homo sapiens	47-50
11991662-5	2002	Removal of uPA from its receptors confers sensitivity to inhibition by amiloride suggesting that a reversible conformational change may mediate the insensitivity of rbuPA to amiloride and its analogs.	Amiloride	71-80	plasminogen activator, urokinase	Homo sapiens	11-14
12571417-6	2002	In the distal colon, electrogenic Na(+) transport (J(Na)) mediated by the epithelial Na(+) channel (ENaC) was measured 8 h after stimulation with 3.10(-9) M aldosterone in vitro as the drop in I(SC) (short circuit current) after addition of 10(-4) M amiloride.	Amiloride	250-259	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	74-98
12455379-9	2002	Under simultaneous stimulation of fluorescein and EGF endocytosis in the presence of the amiloride derivative, such a residual fluorescence shifted with time to the juxtranuclear region, which is characteristic of the late steps of RME.	Amiloride	89-98	epidermal growth factor	Homo sapiens	50-53
11862336-3	2002	This pHi recovery is highly sensitive to the anion exchange inhibitor 4,4"-diisothiocyanato-stilbene-2,2"-disulfonic acid (DIDS) and minimally sensitive to the Na+/H+ exchange inhibitor amiloride, suggesting that it is mostly due to the action of a Na+-dependent HCO3- transporter.	Amiloride	186-195	glucose-6-phosphate isomerase	Homo sapiens	5-8
11862336-5	2002	Preincubation with okadaic acid stimulates the pHi recovery rate from a CO2-induced acid load in the presence of DIDS (0.002 pHu/min vs. 0.065 pHu/min), but not in the presence of amiloride.	Amiloride	180-189	glucose-6-phosphate isomerase	Homo sapiens	47-50
12571417-6	2002	In the distal colon, electrogenic Na(+) transport (J(Na)) mediated by the epithelial Na(+) channel (ENaC) was measured 8 h after stimulation with 3.10(-9) M aldosterone in vitro as the drop in I(SC) (short circuit current) after addition of 10(-4) M amiloride.	Amiloride	250-259	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	100-104
11705781-5	2001	Recovery of pH(i) from acidification in the RTN depended on extracellular Na+ and was inhibited by amiloride but was unaffected by DIDS, suggesting a role for Na+/H+ exchange.	Amiloride	99-108	glucose-6-phosphate isomerase	Rattus norvegicus	12-17
11564737-1	2001	Mammalian Na(+)/H(+) exchanger (NHE) isoforms are differentially sensitive to inhibition by several distinct classes of pharmacological agents, including amiloride- and benzoyl guanidinium-based derivatives.	Amiloride	154-163	solute carrier family 9 member C1	Homo sapiens	10-30
11804183-4	2001	Antibodies to both uPA and uPA receptor (uPAR) were shown to significantly inhibit cell invasion, as did the uPA inhibitors (plasminogen activator inhibitor-1 [PAI-1], p-aminobenzamidine [PABN], aprotinin, and amiloride).	Amiloride	210-219	plasminogen activator, urokinase	Homo sapiens	19-22
11891554-2	2001	Application of Gd3+ to the apical solution of frog skin epithelia increased the Na+ absorption measured as the amiloride-inhibitable short-circuit current (Isc).	Amiloride	111-120	GRDX	Homo sapiens	15-18
11804183-4	2001	Antibodies to both uPA and uPA receptor (uPAR) were shown to significantly inhibit cell invasion, as did the uPA inhibitors (plasminogen activator inhibitor-1 [PAI-1], p-aminobenzamidine [PABN], aprotinin, and amiloride).	Amiloride	210-219	plasminogen activator, urokinase receptor	Homo sapiens	27-39
11804183-4	2001	Antibodies to both uPA and uPA receptor (uPAR) were shown to significantly inhibit cell invasion, as did the uPA inhibitors (plasminogen activator inhibitor-1 [PAI-1], p-aminobenzamidine [PABN], aprotinin, and amiloride).	Amiloride	210-219	plasminogen activator, urokinase receptor	Homo sapiens	41-45
11804183-4	2001	Antibodies to both uPA and uPA receptor (uPAR) were shown to significantly inhibit cell invasion, as did the uPA inhibitors (plasminogen activator inhibitor-1 [PAI-1], p-aminobenzamidine [PABN], aprotinin, and amiloride).	Amiloride	210-219	plasminogen activator, urokinase	Homo sapiens	27-30
11564737-1	2001	Mammalian Na(+)/H(+) exchanger (NHE) isoforms are differentially sensitive to inhibition by several distinct classes of pharmacological agents, including amiloride- and benzoyl guanidinium-based derivatives.	Amiloride	154-163	solute carrier family 9 member C1	Homo sapiens	32-35
11560932-5	2001	In whole cell patch clamp experiments, we found that ET-1 treatment induced a dose-dependent decrease in amiloride-sensitive currents.	Amiloride	105-114	endothelin 1	Mus musculus	53-57
11708789-4	2001	Amiloride and tubocurarine, inhibitors of OCT1, increased MPTP recovery (253 +/- 78 and 283 +/- 64%, respectively) and reduced PS(influx) (0.69 +/- 0.36 to 0.27 +/- 0.11, and 0.97 +/- 0.50 to 0.23 +/- 0.05 ml/s/g, respectively).	Amiloride	0-9	solute carrier family 22 member 1	Rattus norvegicus	42-46
11703599-11	2001	Direct inhibition of this transporter by Ba(2+) and its indirect inhibition by amiloride lead to a strong transepithelial K+ secretion and diminished NaCl reabsorption in the TAL.	Amiloride	79-88	talipes	Mus musculus	175-178
11600418-7	2001	Consistent with the mRNA results, our data showed that amiloride-sensitive (22)Na(+) uptake was increased after incubation of Caco-2 cells with 1 microM TPA for 24 h. To elucidate the role of PKC-alpha, an isoform downregulated by TPA, the relative abundance of NHE isoform mRNA levels and the apical NHE activity were assessed in Caco-2 cells over- and underexpressing PKC-alpha.	Amiloride	55-64	protein kinase C alpha	Homo sapiens	192-201
11600418-7	2001	Consistent with the mRNA results, our data showed that amiloride-sensitive (22)Na(+) uptake was increased after incubation of Caco-2 cells with 1 microM TPA for 24 h. To elucidate the role of PKC-alpha, an isoform downregulated by TPA, the relative abundance of NHE isoform mRNA levels and the apical NHE activity were assessed in Caco-2 cells over- and underexpressing PKC-alpha.	Amiloride	55-64	solute carrier family 9 member C1	Homo sapiens	262-265
11600418-7	2001	Consistent with the mRNA results, our data showed that amiloride-sensitive (22)Na(+) uptake was increased after incubation of Caco-2 cells with 1 microM TPA for 24 h. To elucidate the role of PKC-alpha, an isoform downregulated by TPA, the relative abundance of NHE isoform mRNA levels and the apical NHE activity were assessed in Caco-2 cells over- and underexpressing PKC-alpha.	Amiloride	55-64	solute carrier family 9 member C1	Homo sapiens	301-304
11600418-7	2001	Consistent with the mRNA results, our data showed that amiloride-sensitive (22)Na(+) uptake was increased after incubation of Caco-2 cells with 1 microM TPA for 24 h. To elucidate the role of PKC-alpha, an isoform downregulated by TPA, the relative abundance of NHE isoform mRNA levels and the apical NHE activity were assessed in Caco-2 cells over- and underexpressing PKC-alpha.	Amiloride	55-64	protein kinase C alpha	Homo sapiens	370-379
11758832-7	2001	Cellular acid then exits the cell via an amiloride-inhibitable process, presumably sodium-proton exchange (NHE).	Amiloride	41-50	solute carrier family 9 member C1	Homo sapiens	107-110
11604219-9	2001	Amiloride, a specific NHE 1 inhibitor, and staurosporine a protein kinase C inhibitor were used to inhibit erythrocyte NHE 1.	Amiloride	0-9	solute carrier family 9 member A1	Homo sapiens	119-124
11713657-7	2001	Glucocorticoids induced an amiloride-sensitive Na+ absorption in renal cortical collecting duct and distal colon of MR-/- of about 25% and 50% of the currents observed in glucocorticoid-treated wild-type mice, respectively.	Amiloride	27-36	nuclear receptor subfamily 3, group C, member 2	Mus musculus	116-118
11562773-9	2001	Significant differences were observed in a different region (loop B93-B101), that we identified as binding site of amiloride to the tissue plasminogen activator (tPA).	Amiloride	115-124	chromosome 20 open reading frame 181	Homo sapiens	132-160
11562773-11	2001	Amiloride is a specific inhibitor of uPA but does not inhibit tPA.	Amiloride	0-9	plasminogen activator, urokinase	Homo sapiens	37-40
11683523-9	2001	In conclusion, amiloride, EIPA, and DCB block the pore-forming KIR6.2 subunit of cardiac KATP channels with higher potency than the Na+/H+- and the Na+/Ca2+-exchange, precluding a specific block of the exchanges under ischemic conditions.	Amiloride	15-24	potassium inwardly rectifying channel, subfamily J, member 11	Mus musculus	63-69
11489390-0	2001	A spectrophotometric-partial least squares (PLS-1) method for the simultaneous determination of furosemide and amiloride hydrochloride in pharmaceutical formulations.	Amiloride	111-134	plastin 1	Homo sapiens	44-49
11489390-1	2001	A numerical method, based on the use of spectrophotometric data coupled to PLS-1 multivariate calibration, is reported for the simultaneous determination of furosemide and amiloride hydrochloride in synthetic samples and commercial tablets.	Amiloride	172-195	plastin 1	Homo sapiens	75-80
11504701-0	2001	Lack of amiloride-sensitive transport across alveolar and respiratory epithelium of iNOS(-/-) mice in vivo.	Amiloride	8-17	nitric oxide synthase 2, inducible	Mus musculus	84-88
11504701-8	2001	Nasal potential difference measurements were consistent with alveolar fluid clearance in that both groups of mice had similar baseline values, which were amiloride sensitive in the iNOS(+/+) but not in the iNOS(-/-) mice.	Amiloride	154-163	nitric oxide synthase 2, inducible	Mus musculus	181-185
11504701-5	2001	Amiloride (1.5 mM) decreased alveolar fluid clearance in iNOS(+/+) mice by 61%, whereas forskolin (50 microM) increased alveolar fluid clearance by 55% by stimulating amiloride-insensitive pathways.	Amiloride	0-9	nitric oxide synthase 2, inducible	Mus musculus	57-61
11454671-8	2001	Matrigel invasion assay showed that prostate cancer cell line PC-3, containing amplification of the uPA gene, was more sensitive to the urokinase inhibitor, amiloride, than DU145 or LNCaP cell lines, which do not have the amplification.	Amiloride	157-166	plasminogen activator, urokinase	Homo sapiens	100-103
11493618-8	2001	Addition of amiloride further enhanced inhibition of up-regulation of beta2-integrins.	Amiloride	12-21	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	70-75
11564291-2	2001	The present study investigated the functional role of its subunits in regulating ENaC activity, measured as amiloride sensitive short-circuit current (I(SC)), in the mouse endometrial epithelium under different culture conditions.	Amiloride	108-117	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	81-85
11498511-4	2001	Using extracellular single-unit recording techniques, we found that the ENaC blocker amiloride, and its analogues dimethylamiloride and benzamil caused a reduction in the mechanical activation of guinea-pig airway afferent fibres.	Amiloride	85-94	amiloride-sensitive sodium channel subunit alpha	Cavia porcellus	72-76
11454671-8	2001	Matrigel invasion assay showed that prostate cancer cell line PC-3, containing amplification of the uPA gene, was more sensitive to the urokinase inhibitor, amiloride, than DU145 or LNCaP cell lines, which do not have the amplification.	Amiloride	157-166	serpin family B member 2	Homo sapiens	136-155
11446716-2	2001	We have recently shown that human skin fibroblasts functionally express a phloretin-sensitive Na+-H+ exchange (NHE) which may also be similar to erythrocyte SLC because of amiloride-insensitivity.	Amiloride	172-181	solute carrier family 9 member C1	Homo sapiens	94-109
11408268-8	2001	Inhibition of NHE2 with 10(-5) M and 10(-4) M amiloride significantly increased net HCO(3)(-) output.	Amiloride	46-55	solute carrier family 9 member A2	Homo sapiens	14-18
11408268-9	2001	Moreover, there was an additional, equivalent increase (P < 0.05) in duodenal HCO(3)(-) output with 10(-3) M amiloride, which inhibited NHE3.	Amiloride	112-121	solute carrier family 9 member A3	Homo sapiens	139-143
11463765-1	2001	The SCNN1G gene, located on human chromosome 16p12, encodes the gamma subunit of the amiloride-sensitive epithelial sodium channel, and mutations in SCNN1G can result in Liddle"s syndrome or pseudohypoaldosteronism type I.	Amiloride	85-94	sodium channel epithelial 1 subunit gamma	Homo sapiens	4-10
11389186-7	2001	The DAT inhibitor, WIN-35,428, protected completely against METH-induced DA neurotoxicity in AMIL pretreated animals, suggesting that the potentiating effects of AMIL require a METH/DAT interaction.	Amiloride	93-97	solute carrier family 6 member 3	Rattus norvegicus	4-7
11350806-7	2001	The TNF-alpha-elicited Na(+) current was inhibited by amiloride, and there was no change when A549 cells were perfused with the triple-mutant TNF-alpha or after preincubation with blocking antibodies to the two TNF-alpha receptors before perfusion with TNF-alpha.	Amiloride	54-63	tumor necrosis factor	Homo sapiens	4-13
11350806-8	2001	In conclusion, although TNF- alpha can initiate acute inflammation and edema formation in the lung, TNF-alpha can also increase AFC by an amiloride-sensitive, cAMP-independent mechanism that enhances the resolution of alveolar edema in pathological conditions by either binding to its receptors or activating Na(+) channels by means of its lectinlike domain.	Amiloride	138-147	tumor necrosis factor	Homo sapiens	100-109
11758807-6	2001	The activity was inhibited by amiloride, a specific inhibitor of uPA.	Amiloride	30-39	plasminogen activator, urokinase	Homo sapiens	65-68
11435462-6	2001	In addition, up to 80% of amiloride-insensitive pH(i) recovery from acid load in the presence of HCO(3)(-)/CO(2) was inhibited by adenovirus-mediated transfer of a specific hammerhead ribozyme against NBC-1, consistent with a major role of NBC-1 in overall HCO(3)-transport by the lens epithelium.	Amiloride	26-35	solute carrier family 4 member 4	Homo sapiens	201-206
11435462-6	2001	In addition, up to 80% of amiloride-insensitive pH(i) recovery from acid load in the presence of HCO(3)(-)/CO(2) was inhibited by adenovirus-mediated transfer of a specific hammerhead ribozyme against NBC-1, consistent with a major role of NBC-1 in overall HCO(3)-transport by the lens epithelium.	Amiloride	26-35	solute carrier family 4 member 4	Homo sapiens	240-245
11350741-2	2001	PAR2 activators, added to the basolateral membrane, caused a transient, Ca2+-dependent increase in short-circuit current (I(sc)), followed by a sustained inhibition of amiloride-sensitive I(sc).	Amiloride	168-177	F2R like trypsin receptor 1	Homo sapiens	0-4
11389186-7	2001	The DAT inhibitor, WIN-35,428, protected completely against METH-induced DA neurotoxicity in AMIL pretreated animals, suggesting that the potentiating effects of AMIL require a METH/DAT interaction.	Amiloride	162-166	solute carrier family 6 member 3	Rattus norvegicus	4-7
11373334-8	2001	Coexpression of rat prostasin and rat ENaC in Xenopus oocytes increased the amiloride-sensitive sodium current by twofold.	Amiloride	76-85	serine protease 8	Rattus norvegicus	20-29
11226330-9	2001	These cells possess amiloride-sensitive NHE.	Amiloride	20-29	solute carrier family 9 member C1	Homo sapiens	40-43
11373334-8	2001	Coexpression of rat prostasin and rat ENaC in Xenopus oocytes increased the amiloride-sensitive sodium current by twofold.	Amiloride	76-85	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	38-42
11285365-6	2001	NHE-mediated pH(i) recovery from acid load was less than 50% that in 786-O Neo cells, whereas hypertonicity-stimulated, amiloride-sensitive NHE was indistinguishable in the two cell lines.	Amiloride	120-129	solute carrier family 9 member C1	Homo sapiens	140-143
11284207-1	2001	An amiloride-sensitive, Ca(2+)-activated nonselective cation (NSC) channel in the apical membrane of fetal rat alveolar epithelium plays an important role in stimulation of Na+ transport by a beta adrenergic agonist (beta agonist).	Amiloride	3-12	amyloid beta precursor protein	Rattus norvegicus	190-196
11390018-2	2001	Ligand binding to rodent pancreatic polypeptide-responding neuropeptide Y (NPY) receptors (here termed PP/NPY receptors), or to cloned Y4 or Y5 receptors, is selectively inhibited by amiloride, peptide or alkylating modulators of sodium transport.	Amiloride	183-192	pancreatic polypeptide	Homo sapiens	25-47
11390018-2	2001	Ligand binding to rodent pancreatic polypeptide-responding neuropeptide Y (NPY) receptors (here termed PP/NPY receptors), or to cloned Y4 or Y5 receptors, is selectively inhibited by amiloride, peptide or alkylating modulators of sodium transport.	Amiloride	183-192	neuropeptide Y	Homo sapiens	59-73
11390018-2	2001	Ligand binding to rodent pancreatic polypeptide-responding neuropeptide Y (NPY) receptors (here termed PP/NPY receptors), or to cloned Y4 or Y5 receptors, is selectively inhibited by amiloride, peptide or alkylating modulators of sodium transport.	Amiloride	183-192	neuropeptide Y	Rattus norvegicus	75-78
11390018-2	2001	Ligand binding to rodent pancreatic polypeptide-responding neuropeptide Y (NPY) receptors (here termed PP/NPY receptors), or to cloned Y4 or Y5 receptors, is selectively inhibited by amiloride, peptide or alkylating modulators of sodium transport.	Amiloride	183-192	neuropeptide Y	Rattus norvegicus	106-109
11350050-6	2001	Electrophysiological studies using excised outside-in membrane patches showed a low-conductance, Na+-selective, dichlorobenzamil-sensitive, amiloride-insensitive channel that we tentatively assigned as being an NCX.	Amiloride	140-149	T cell leukemia homeobox 2	Homo sapiens	211-214
11344206-2	2001	There are 2 forms of PHA1: the autosomal recessive form with symptoms persisting into adulthood, caused by mutations in the amiloride-sensitive luminal sodium channel, and the autosomal dominant or sporadic form, which shows milder symptoms that remit with age.	Amiloride	124-133	sodium channel epithelial 1 subunit gamma	Homo sapiens	21-25
11297748-1	2001	The epithelial Na(+) channel (ENaC) is composed of the subunits alpha, beta, and gamma [Canessa et al., Nature 367 (1994) 463-467] and typically exhibits a high affinity to amiloride [Canessa et al., Nature 361 (1993) 467-470].	Amiloride	173-182	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	4-28
11297748-1	2001	The epithelial Na(+) channel (ENaC) is composed of the subunits alpha, beta, and gamma [Canessa et al., Nature 367 (1994) 463-467] and typically exhibits a high affinity to amiloride [Canessa et al., Nature 361 (1993) 467-470].	Amiloride	173-182	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	30-34
11248216-7	2001	Physiological regulation of intracellular pH using a pH-sensitive dye, BCECF, detected an amiloride-sensitive NHE activity in human keratinocyte, melanocyte and melanoma cell cultures.	Amiloride	90-99	solute carrier family 9 member C1	Homo sapiens	110-113
11181403-14	2001	Inhibition of NHE1 but not NHE3 expression abolishes amiloride-suppressible NHE activity.	Amiloride	53-62	solute carrier family 9 member A1	Homo sapiens	14-18
11181403-14	2001	Inhibition of NHE1 but not NHE3 expression abolishes amiloride-suppressible NHE activity.	Amiloride	53-62	solute carrier family 9 member C1	Homo sapiens	14-17
11322198-5	2001	Amiloride (100 micromol/l) and 20 micromol/l 5-N-ethyl-N-isopropyl-amiloride completely inhibited HSC proliferation (evaluated by measurement of bromodeoxyuridine incorporation) induced by PDGF and IGF-1, but did not affect proliferation of HSC induced by insulin.	Amiloride	0-9	insulin like growth factor 1	Homo sapiens	198-203
11410707-4	2001	In oocytes expressing the alphaENaC splice variant, together with beta and gammaENaC subunits, amiloride-sensitive currents were less than 20% of values obtained with the wild type ENaC.	Amiloride	95-104	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	31-35
11269510-8	2001	Treatment with the specific epithelial sodium channel blocker amiloride led to a much higher increase in fractional sodium excretion in ETB-deficient rats (934.2+/-73% in ETB-deficient rats versus 297+/-20% in wild-type rats, expressed as percentage of corresponding placebo treated control; P<0.001).	Amiloride	62-71	endothelin receptor type B	Rattus norvegicus	136-139
11509829-9	2001	h-SGK1 accelerated the expression of the amiloride sensitive Na(+)- current in Xenopus oocytes paralleled by increased ENaC-protein abundance in the oocyte membrane, an effect which was reversed by a h-SGK1(K127R) mutation lacking the ATP-binding site.	Amiloride	41-50	serum/glucocorticoid regulated kinase 1 L homeolog	Xenopus laevis	2-6
11509829-9	2001	h-SGK1 accelerated the expression of the amiloride sensitive Na(+)- current in Xenopus oocytes paralleled by increased ENaC-protein abundance in the oocyte membrane, an effect which was reversed by a h-SGK1(K127R) mutation lacking the ATP-binding site.	Amiloride	41-50	serum/glucocorticoid regulated kinase 1 L homeolog	Xenopus laevis	202-206
11509829-11	2001	However, coexpression of h-SGK1 with ENaC altered the sensitivity of the Na(+)-channel to the inhibitors amiloride and triamterene.	Amiloride	105-114	serum/glucocorticoid regulated kinase 1 L homeolog	Xenopus laevis	27-31
11340305-4	2001	Amiloride reduced MCP-1 in cells stimulated with ouabain, lipopolysaccharide (LPS) or albumin.	Amiloride	0-9	chemokine (C-C motif) ligand 2	Mus musculus	18-23
11340305-9	2001	Thus, amiloride and ouabain may alter tubular cell MCP-1 by changing intracellular Na+, with secondary changes in intracellular Ca2+, whereas stimulation by LPS and albumin may involve Ca2+ directly.	Amiloride	6-15	chemokine (C-C motif) ligand 2	Mus musculus	51-56
11684814-6	2001	This effect of insulin was inhibited by amiloride and by staurosporine as well.	Amiloride	40-49	insulin	Homo sapiens	15-22
11269510-8	2001	Treatment with the specific epithelial sodium channel blocker amiloride led to a much higher increase in fractional sodium excretion in ETB-deficient rats (934.2+/-73% in ETB-deficient rats versus 297+/-20% in wild-type rats, expressed as percentage of corresponding placebo treated control; P<0.001).	Amiloride	62-71	endothelin receptor type B	Rattus norvegicus	171-174
11040058-0	2000	Agonist binding and function at the human alpha(2A)-adrenoceptor: allosteric modulation by amilorides.	Amiloride	91-101	adrenoceptor alpha 2A	Homo sapiens	42-64
11142655-5	2000	Adding 100 microM amiloride raised both NaCl and NaGlu thresholds but did not abolish all performance to NaGlu, indicating that some chemical cue was present at high concentrations.	Amiloride	18-27	N-acetyl-alpha-glucosaminidase	Rattus norvegicus	49-54
12845338-5	2000	Several amiloride analogs non-selectively inhibit all isoforms of NHE and have been demonstrated to confer cardioprotection against ischemia-reperfusion injury in a number of experimental models with infarction, contractility, enzyme release and arrhythmias as endpoint.	Amiloride	8-17	solute carrier family 9 member C1	Homo sapiens	66-69
11845319-0	2001	Inhibition of amiloride-sensitive Na(+) absorption by activation of CFTR in mouse endometrial epithelium.	Amiloride	14-23	cystic fibrosis transmembrane conductance regulator	Mus musculus	68-72
11845319-1	2001	Previous studies have demonstrated amiloride-sensitive Na(+) absorption under basal conditions and cystic fibrosis transmembrane conductance regulator (CFTR)-mediated Cl(-) secretion following neurohormonal stimulation in the mouse endometrial epithelium.	Amiloride	35-44	cystic fibrosis transmembrane conductance regulator	Mus musculus	152-156
11845319-2	2001	The present study investigated the inhibition of amiloride-sensitive Na(+) absorption accompanying activation of CFTR in the mouse endometrium using the short-circuit current ( I(sc)) technique.	Amiloride	49-58	cystic fibrosis transmembrane conductance regulator	Mus musculus	113-117
11845319-3	2001	RT-PCR demonstrated the co-expression of CFTR and epithelial Na(+) channels (ENaC) in primary cultured mouse endometrial epithelia and cultured endometrial monolayers exhibited a basal amiloride-sensitive I(sc) of 5.4 +/- 0.6 microA/cm(2).	Amiloride	185-194	cystic fibrosis transmembrane conductance regulator	Mus musculus	41-45
12567909-2	2000	The interactions between agents such as thyroxine, Ang II and phenylephrine which induced hypertrophy with amiloride on the calcium current were analyzed.	Amiloride	107-116	angiogenin	Rattus norvegicus	51-54
11052984-3	2000	Presence of rat ENaC was determined by amiloride inhibition of (22)Na(+) uptake in surface colonocytes 7 and 14 days after partial portal vein ligation (PVL) or sham surgery.	Amiloride	39-48	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	16-20
11294008-13	2000	Inhibition of u-PA by amiloride seems to be responsible for this effect.	Amiloride	22-31	plasminogen activator, urokinase	Rattus norvegicus	14-18
10998367-0	2000	Arabidopsis thaliana and Saccharomyces cerevisiae NHX1 genes encode amiloride sensitive electroneutral Na+/H+ exchangers.	Amiloride	68-77	bifunctional K:H/Na:H antiporter NHX1	Saccharomyces cerevisiae S288C	50-54
10998367-9	2000	Whereas At-NHX1 was completely inhibited by amiloride, NHX1 activity was reduced by only 20-40%.	Amiloride	44-53	bifunctional K:H/Na:H antiporter NHX1	Saccharomyces cerevisiae S288C	11-15
11006079-2	2000	The amiloride sensitivity of the basal current of the cultured endometrial epithelia was found to vary with the magnitude of the basal current, the higher the basal current the greater its sensitivity to amiloride, indicating possible elevation of ENaC expression.	Amiloride	4-13	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	248-252
11029040-3	2000	In fibroblasts PAK1 localizes to areas of membrane ruffling, as well as to amiloride-sensitive pinocytic vesicles.	Amiloride	75-84	p21 (RAC1) activated kinase 1	Mus musculus	15-19
11006079-3	2000	However, the magnitude of the forskolin-induced Isc, previously demonstrated to be mediated by CFTR, decreased as the amiloride sensitivity of the basal current increased, suggesting a possible inhibitory effect of elevated expression of ENaC on CFTR-mediated Cl(-) secretion.	Amiloride	118-127	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	238-242
11006079-3	2000	However, the magnitude of the forskolin-induced Isc, previously demonstrated to be mediated by CFTR, decreased as the amiloride sensitivity of the basal current increased, suggesting a possible inhibitory effect of elevated expression of ENaC on CFTR-mediated Cl(-) secretion.	Amiloride	118-127	cystic fibrosis transmembrane conductance regulator	Mus musculus	246-250
11208427-5	2000	Preincubation with AMI influenced the dPD in all tissues but the PD of the frog skin was only depolarized.	Amiloride	19-22	dachs	Drosophila melanogaster	38-41
10984619-1	2000	The alpha and beta subunits of the amiloride-sensitive rat epithelial sodium channel (alpha beta ENaC) were expressed in the yeast Saccharomyces cerevisiae.	Amiloride	35-44	sodium channel epithelial 1 subunit beta	Rattus norvegicus	92-101
10984619-4	2000	In addition, amiloride, a specific blocker of ENaC, was found to suppress salt sensitivity in the yeast strain expressing alpha beta ENaC.	Amiloride	13-22	sodium channel epithelial 1 subunit beta	Rattus norvegicus	128-137
11208427-5	2000	Preincubation with AMI influenced the dPD in all tissues but the PD of the frog skin was only depolarized.	Amiloride	19-22	dachs	Drosophila melanogaster	39-41
10958346-4	2000	Blocking the apical Na+/H+ exchanger isoform NHE2 by amiloride or HOE642 diminished absorptive Na+ and Cl- fluxes.	Amiloride	53-62	solute carrier family 9 member A2	Rattus norvegicus	45-49
11007305-7	2000	Acid-activated 22Na+ uptake was inhibited by cariporide, EIPA (ethyl-isopropyl-amiloride) and amiloride, at concentrations characteristic of the NHE-1 isoform.	Amiloride	79-88	sodium/hydrogen exchanger 1	Bos taurus	145-150
11007312-2	2000	Cell pH (pHi) measurements using a pH-sensitive fluorescence probe in the absence of HCO3-/CO2 revealed the presence of a Na+/H+ exchanger that required high concentrations of amiloride for full inhibition.	Amiloride	176-185	glucose-6-phosphate isomerase	Homo sapiens	9-12
10878096-5	2000	Amiloride infusion significantly increased FE(Na) in both wild-type (3.14 +/- 0.83 %, n = 6) and Cftr(tm2cam) delta F508 mice (3.	Amiloride	0-9	cystic fibrosis transmembrane conductance regulator	Mus musculus	97-101
10886036-5	2000	For cells at steady-state pHi, resuspension in hyperosmotic solutions elicited an alkalinization, which was significantly inhibited by removal of extracellular Na+ ions, or treatment with amiloride (1 mM) or HOE-694 (10 microM), both inhibitors of Na+ x H+ exchange.	Amiloride	188-197	glucose-6-phosphate isomerase	Bos taurus	26-29
10878096-9	2000	Treatment of salt-restricted mice with amiloride resulted in a blunted natriuresis in both wild-type mice (FE(Na) = 1.10 +/- 0.16 %, n = 7) and Cftr(tm2cam) delta F508 mice (FE(Na) = 1.97 +/- 0.29 %, n = 9).	Amiloride	39-48	cystic fibrosis transmembrane conductance regulator	Mus musculus	144-148
10878096-10	2000	The natriuresis induced by amiloride was significantly greater in Cftr(tm2cam) delta F508 mice than in wild-type controls.	Amiloride	27-36	cystic fibrosis transmembrane conductance regulator	Mus musculus	66-70
10864001-6	2000	pHi recovery from an NH4+-induced acid load was blocked by sodium removal or amiloride addition.	Amiloride	77-86	glucose-6-phosphate isomerase	Homo sapiens	0-3
10835324-7	2000	At rest, both types of cells showed an amiloride-sensitive fluid absorption that was inhibited by interferon-gamma but not by tumor necrosis factor-alpha.	Amiloride	39-48	interferon gamma	Homo sapiens	98-114
10841524-3	2000	Basolateral Na(+)-dependent H(+) efflux in the microperfused duct was inhibited by 1.5 microM of the amiloride analogue HOE 694, consistent with expression of NHE1, whereas the luminal activity required 50 microM HOE 694 for effective inhibition, suggesting that the efflux might be mediated by NHE2.	Amiloride	101-110	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	159-163
10788432-5	2000	The forskolin/3-isobutyl-1-methylxanthine-stimulated whole-cell conductance in hCFTR-mENaC co-injected oocytes was amiloride-insensitive, indicating an inhibition of mENaC following hCFTR activation, and it was blocked by DPC (diphenylamine-2-carboxylic acid) and was DIDS (4, 4"-diisothiocyanatostilbene-2,2"-disulfonic acid)-insensitive.	Amiloride	115-124	CF transmembrane conductance regulator	Homo sapiens	79-84
10788432-5	2000	The forskolin/3-isobutyl-1-methylxanthine-stimulated whole-cell conductance in hCFTR-mENaC co-injected oocytes was amiloride-insensitive, indicating an inhibition of mENaC following hCFTR activation, and it was blocked by DPC (diphenylamine-2-carboxylic acid) and was DIDS (4, 4"-diisothiocyanatostilbene-2,2"-disulfonic acid)-insensitive.	Amiloride	115-124	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	85-90
10824746-0	2000	Suppression of the invasive capacity of human breast cancer cells by inhibition of urokinase plasminogen activator via amiloride and B428.	Amiloride	119-128	plasminogen activator, urokinase	Homo sapiens	83-114
10824746-3	2000	In this study using Matrigel invasion chambers and two separate uPA inhibitors, amiloride and B428, the invasive capacity of unaltered human breast cancer cells was significantly suppressed.	Amiloride	80-89	plasminogen activator, urokinase	Homo sapiens	64-67
10864007-8	2000	These results suggest that the common, amiloride-sensitive, basolateral Na+/H+ exchanger plays a role in the regulation of pHi in rat papillary DTL but that a different basolateral Na+/H+ exchanger or a luminal Na+/H+ exchanger is important in rat papillary ATL.	Amiloride	39-48	glucose-6-phosphate isomerase	Rattus norvegicus	123-126
10751222-8	2000	Coexpressing sgk and ENaC in Xenopus oocytes evoked a fourfold increase in the amiloride-blockable Na(+) channel activity.	Amiloride	79-88	serum/glucocorticoid regulated kinase 1 L homeolog	Xenopus laevis	13-16
10767424-5	2000	hINaC is not activated by lowering the external pH but gain-of-function mutations can be introduced and reveal when expressed in Xenopus oocytes, an important Na(+) channel activity which is blocked by amiloride (IC(50)=0.5 microM).	Amiloride	202-211	acid sensing ion channel subunit family member 5	Homo sapiens	0-5
10749572-8	2000	Normal pressure is restored in salt-fed DBH-ET(B);ET(B)(sl/sl) rats when the epithelial sodium channel is blocked with amiloride.	Amiloride	119-128	dopamine beta-hydroxylase	Rattus norvegicus	40-43
10749572-8	2000	Normal pressure is restored in salt-fed DBH-ET(B);ET(B)(sl/sl) rats when the epithelial sodium channel is blocked with amiloride.	Amiloride	119-128	endothelin receptor type B	Rattus norvegicus	44-49
10749572-8	2000	Normal pressure is restored in salt-fed DBH-ET(B);ET(B)(sl/sl) rats when the epithelial sodium channel is blocked with amiloride.	Amiloride	119-128	endothelin receptor type B	Rattus norvegicus	50-55
10692428-3	2000	Pharmacological analyses revealed that H(+)(i)-activated (22)Na(+) influx mediated by NHE5 was inhibited by several classes of drugs (amiloride compounds, 3-methylsulfonyl-4-piperidinobenzoyl guanidine methanesulfonate, cimetidine, and harmaline) at half-maximal concentrations that were intermediate to those determined for the high affinity NHE1 and the low affinity NHE3 isoforms, but closer to the latter.	Amiloride	134-143	solute carrier family 9 member A5	Homo sapiens	86-90
10760056-13	2000	Expression of sgk resulted in a significant increase in the amiloride-sensitive Na current, suggesting that this protein kinase plays an important role in the early phase of aldosterone-stimulated Na transport.	Amiloride	60-69	serum/glucocorticoid regulated kinase 1	Mus musculus	14-17
10720630-0	2000	Modulation of the Ca(2+) release channel of sarcoplasmic reticulum by amiloride analogs.	Amiloride	70-79	ryanodine receptor 2	Oryctolagus cuniculus	18-40
10720630-4	2000	It is concluded that stimulation of the sarcoplasmic reticulum Ca(2+) release channel accounts for the dichlorobenzamil- or phenamil-induced tension in skinned fibers, whereas depletion of sarcoplasmic reticulum Ca(2+) stores and channel block (with dichlorobenzamil) explains the inhibition of the caffeine-evoked tension by amiloride analogs.	Amiloride	326-335	ryanodine receptor 2	Oryctolagus cuniculus	63-85
10692428-8	2000	Overall, these functional features distinguish NHE5 from other family members and closely resemble those of an amiloride-resistant NHE isoform identified in hippocampal neurons.	Amiloride	111-120	solute carrier family 9 member A5	Homo sapiens	47-51
10692428-8	2000	Overall, these functional features distinguish NHE5 from other family members and closely resemble those of an amiloride-resistant NHE isoform identified in hippocampal neurons.	Amiloride	111-120	solute carrier family 9 member C1	Homo sapiens	47-50
10706990-4	2000	As activation of Na(+)/H(+)-exchangers (NHE) is involved in the recovery from neuronal acidosis and NHE-inhibition alone is known to increase the activity of intracellular free protons of hippocampal neurones, we tested the effect of the NHE-blockers amiloride (0.5-1 mM) or HOE642 (200 microM) on SBA and EA of CA3-neurones.	Amiloride	251-260	solute carrier family 9 member C1	Homo sapiens	40-43
10706990-4	2000	As activation of Na(+)/H(+)-exchangers (NHE) is involved in the recovery from neuronal acidosis and NHE-inhibition alone is known to increase the activity of intracellular free protons of hippocampal neurones, we tested the effect of the NHE-blockers amiloride (0.5-1 mM) or HOE642 (200 microM) on SBA and EA of CA3-neurones.	Amiloride	251-260	solute carrier family 9 member C1	Homo sapiens	100-103
10706990-4	2000	As activation of Na(+)/H(+)-exchangers (NHE) is involved in the recovery from neuronal acidosis and NHE-inhibition alone is known to increase the activity of intracellular free protons of hippocampal neurones, we tested the effect of the NHE-blockers amiloride (0.5-1 mM) or HOE642 (200 microM) on SBA and EA of CA3-neurones.	Amiloride	251-260	solute carrier family 9 member C1	Homo sapiens	100-103
10665489-7	2000	The neurotoxicity caused by Tat and gp120 applied in combination was blocked completely by memantine, partially by amiloride, and not at all by dipyridamole or vigabatrin.	Amiloride	115-124	tyrosine aminotransferase	Homo sapiens	28-31
10692482-0	2000	Allosteric interactions between the antagonist prazosin and amiloride analogs at the human alpha(1A)-adrenergic receptor.	Amiloride	60-69	adrenoceptor alpha 1D	Homo sapiens	91-120
10692482-1	2000	It has been demonstrated previously that amilorides can interact with a well defined allosteric site on the human alpha(2A)-adrenergic receptor.	Amiloride	41-51	adrenoceptor alpha 2A	Homo sapiens	114-143
10692482-4	2000	With the parent amiloride, the dissociation data were well fitted by an equation derived from the ternary complex allosteric model, compatible with amiloride acting at a defined allosteric site on the alpha(1A)-adrenergic receptor.	Amiloride	148-157	adrenoceptor alpha 1D	Homo sapiens	201-230
10692482-10	2000	The interactions of the five amiloride analogs, but not the parent amiloride, with the alpha(1A)-adrenergic receptor are compatible with the presence of two (but not one) allosteric sites, and is thus more complex than that found for the alpha(2A)-adrenergic receptor.	Amiloride	29-38	adrenoceptor alpha 1D	Homo sapiens	87-116
10692482-10	2000	The interactions of the five amiloride analogs, but not the parent amiloride, with the alpha(1A)-adrenergic receptor are compatible with the presence of two (but not one) allosteric sites, and is thus more complex than that found for the alpha(2A)-adrenergic receptor.	Amiloride	29-38	adrenoceptor alpha 2A	Homo sapiens	238-267
10665489-7	2000	The neurotoxicity caused by Tat and gp120 applied in combination was blocked completely by memantine, partially by amiloride, and not at all by dipyridamole or vigabatrin.	Amiloride	115-124	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	36-41
11688549-3	2000	The transport amiloride-sensitive mechanism, that decreased the acidic intracellular pH change occurring in this medium, would correspond to Na+-H+ exchange (NHE1 isoform).	Amiloride	14-23	solute carrier family 9 member A1	Homo sapiens	158-162
10711410-5	2000	RESULTS: Amiloride and 5-(N-ethyl-N-isopropyl) amiloride (EIPA) inhibited the NHE activity with half-maximal inhibition values (IC50) of 15.3 and 4.0 microM, respectively.	Amiloride	9-18	solute carrier family 9 member C1	Homo sapiens	78-81
10711410-7	2000	CONCLUSION: These results suggest that cultured PT cells isolated from human urine express amiloride-resistant NHE-3 activity on the apical membranes, which can be compared to functional properties of PT in vivo.	Amiloride	91-100	solute carrier family 9 member A3	Homo sapiens	111-116
11125214-6	2000	With respect to the molecular correlate of the volume activated Na(+) conductance it could be shown that it exhibits a rather low affinity to amiloride (IC(50) = 6.0 micromol/l) and an overall sensitivity profile of EIPA > amiloride > benzamil = phenamil that, at first sight, would not speak in favor of a typical epithelial type of Na(+) channel (ENaC).	Amiloride	142-151	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	355-359
10631140-6	2000	Extending telomerically from the SRO, two additional genes-BLMH, encoding a hydrolase involved in bleomycin resistance, and ACCN1, encoding an amiloride-sensitive cation channel expressed in the CNS-were located in the deleted intervals of seven and three patients, respectively.	Amiloride	143-152	bleomycin hydrolase	Homo sapiens	59-63
10631140-6	2000	Extending telomerically from the SRO, two additional genes-BLMH, encoding a hydrolase involved in bleomycin resistance, and ACCN1, encoding an amiloride-sensitive cation channel expressed in the CNS-were located in the deleted intervals of seven and three patients, respectively.	Amiloride	143-152	acid sensing ion channel subunit 2	Homo sapiens	124-129
10696530-3	2000	The ENaC-mediated sodium transport is electrogenic and creates an amiloride-sensitive transepithelial potential difference (PD).	Amiloride	66-75	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	4-8
11093028-7	2000	Moreover, hSGK decreases the affinity to amiloride (increase of IC(50) from 0.12 to 0.26 micromol/l) and increases the affinity to EIPA (decrease of IC(50) from 250 to 50 micromol/l).	Amiloride	41-50	serum/glucocorticoid regulated kinase 1	Homo sapiens	10-14
11093028-9	2000	ENaC may contribute to the Na(+) channels activated by osmotic cell shrinkage in hepatocytes, whereby the relatively low amiloride and high EIPA sensitivity of the channel could at least be partially due to modification by SGK, which decreases the amiloride and increases the EIPA sensitivity of ENaC.	Amiloride	248-257	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	223-226
10696530-13	2000	In mice treated with an AngII AT1 receptor antagonist, amiloride-sensitive rectal PD was increased in the afternoon compared with controls (-32.8 +/- 2.0 vs -24.4 +/- 0.9, respectively; P < 0.001).	Amiloride	55-64	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	24-29
10696530-15	2000	At high doses, AngII decreased the amiloride-sensitive rectal PD and this effect was blunted by an AT1 receptor antagonist.	Amiloride	35-44	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	15-20
10600757-2	1999	Amiloride (10 microM) produced approximately 20-30% inhibition of the whole cell conductance in both the presence and absence of EGF, such that EGF caused the magnitude of the amiloride-sensitive component to more than double.	Amiloride	0-9	epidermal growth factor like 1	Rattus norvegicus	129-132
10608847-1	1999	The serum- and glucocorticoid-induced kinase (sgk) is a serine and threonine kinase that stimulates amiloride-sensitive sodium transport in Xenopus oocytes.	Amiloride	100-109	serum/glucocorticoid regulated kinase 1 L homeolog	Xenopus laevis	4-44
10608847-1	1999	The serum- and glucocorticoid-induced kinase (sgk) is a serine and threonine kinase that stimulates amiloride-sensitive sodium transport in Xenopus oocytes.	Amiloride	100-109	serum/glucocorticoid regulated kinase 1 L homeolog	Xenopus laevis	46-49
10600757-2	1999	Amiloride (10 microM) produced approximately 20-30% inhibition of the whole cell conductance in both the presence and absence of EGF, such that EGF caused the magnitude of the amiloride-sensitive component to more than double.	Amiloride	0-9	epidermal growth factor like 1	Rattus norvegicus	144-147
10600757-2	1999	Amiloride (10 microM) produced approximately 20-30% inhibition of the whole cell conductance in both the presence and absence of EGF, such that EGF caused the magnitude of the amiloride-sensitive component to more than double.	Amiloride	176-185	epidermal growth factor like 1	Rattus norvegicus	144-147
10540321-5	1999	The amiloride sensitivity of the observed activity suggests a binding of TNF to an endogenous ion channel rather than channel formation by TNF itself.	Amiloride	4-13	tumor necrosis factor	Mus musculus	73-76
10552015-6	1999	A blocker of Na(+)/H(+) antiporters, amiloride, largely inhibited the Na(+) removal-induced suppression of whole-cell ROMK1 currents in the oocytes.	Amiloride	37-46	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	118-123
10470997-8	1999	In contrast to noradrenaline-induced vasoconstriction, the vasoconstrictor response to angiotensin II was significantly attenuated by amiloride (p = 0.02).	Amiloride	134-143	angiotensinogen	Homo sapiens	87-101
11270998-5	1999	Inhibition of Na+/H+ exchange with amiloride (Ami) 400 mumol.L-1 resulted in an inhibition of P-selectin expression [(37.5 +/- 2.1)% vs (47.5 +/- 1.3)% of PAF group, P < 0.01].	Amiloride	35-44	selectin P	Homo sapiens	94-104
11270998-5	1999	Inhibition of Na+/H+ exchange with amiloride (Ami) 400 mumol.L-1 resulted in an inhibition of P-selectin expression [(37.5 +/- 2.1)% vs (47.5 +/- 1.3)% of PAF group, P < 0.01].	Amiloride	46-49	selectin P	Homo sapiens	94-104
11270998-5	1999	Inhibition of Na+/H+ exchange with amiloride (Ami) 400 mumol.L-1 resulted in an inhibition of P-selectin expression [(37.5 +/- 2.1)% vs (47.5 +/- 1.3)% of PAF group, P < 0.01].	Amiloride	46-49	PCNA clamp associated factor	Homo sapiens	155-158
10457052-7	1999	The activated channel was amiloride sensitive (IC50, 1.31 microM) and displayed a low conductance (9-10 pS) and a high selectivity for Na+ over K+ (ratio of the respective permeabilities, PNa+/PK+ >= 10), all of which are characteristic of NaC/DEG channel behaviour.	Amiloride	26-35	X-linked Kx blood group	Homo sapiens	243-246
10521142-6	1999	Inhibition of membrane transporters responsible for pHi regulation (0.1 mM amiloride for the Na+/H+ antiporter or 1 mM SITS for HCO3- -dependent transporters) inhibited cell swelling from acidosis but did not affect the profound intracellular acidification.	Amiloride	75-84	glucose-6-phosphate isomerase	Homo sapiens	52-55
10544394-14	1999	Inhibition of uPA by amiloride appears to be responsible for these effects.	Amiloride	21-30	urokinase-type plasminogen activator	Oryctolagus cuniculus	14-17
10438504-3	1999	We have also addressed whether Apx is required for the expression of amiloride-sensitive Na(+) currents by cloned ENaC.	Amiloride	69-78	shroom family member 1 L homeolog	Xenopus laevis	31-34
10428051-11	1999	This stimulatory effect of anti-GM1 on cell proliferation was blocked by amiloride but not by PTx, suggesting that the influx of Ca2+ was essentially required for cell proliferation.	Amiloride	73-82	coenzyme Q10A	Mus musculus	32-35
10444453-6	1999	Stable expression of transfected full-length hNHE2 cDNA in Na(+)/H(+) exchange-deficient LAP1 cells exhibited Na(+)-dependent pH recovery after an acid prepulse that was inhibited by 0.1 mM amiloride.	Amiloride	190-199	solute carrier family 9 member A2	Homo sapiens	45-50
10395929-4	1999	The deduced amino acid sequence is similar to that of NHX1 and NHE isoforms in mammals, and shares high similarity with the sequences within predicted transmembrane segments and an amiloride-binding domain.	Amiloride	181-190	bifunctional K:H/Na:H antiporter NHX1	Saccharomyces cerevisiae S288C	54-58
10409305-7	1999	Injection of mouse alpha-, beta-, and gammaENaC cRNAs into Xenopus oocytes led to expression of amiloride-sensitive (K(i) = 103 nM), Na(+)-selective currents with a single-channel conductance of 4.7 pS.	Amiloride	96-105	sodium channel, nonvoltage-gated 1 gamma	Mus musculus	19-47
10443477-2	1999	In the presence of 10(-4) M amiloride, the addition of VIP to the serosal solution led to an increase in the Isc in a concentration-dependent manner, the 50% effective concentration (EC50) being 2.6 x 10(-11) M. However, the addition of 10(-5) M forskolin had little effect on the increase in Isc.	Amiloride	28-37	vasoactive intestinal peptide	Homo sapiens	55-58
10377062-4	1999	Addition of amiloride, a competitive inhibitor of urokinase-type PA (uPA), to the zymogram eliminated the activity of the 58.5 +/- 3.5-kDa zone, suggesting that this band is a uPA.	Amiloride	12-21	plasminogen activator, urokinase	Bos taurus	50-67
10377062-4	1999	Addition of amiloride, a competitive inhibitor of urokinase-type PA (uPA), to the zymogram eliminated the activity of the 58.5 +/- 3.5-kDa zone, suggesting that this band is a uPA.	Amiloride	12-21	plasminogen activator, urokinase	Bos taurus	69-72
10377062-4	1999	Addition of amiloride, a competitive inhibitor of urokinase-type PA (uPA), to the zymogram eliminated the activity of the 58.5 +/- 3.5-kDa zone, suggesting that this band is a uPA.	Amiloride	12-21	plasminogen activator, urokinase	Bos taurus	176-179
10738907-0	1999	Molecular basis of specific inhibition of urokinase plasminogen activator by amiloride.	Amiloride	77-86	plasminogen activator, urokinase	Homo sapiens	42-73
10738907-6	1999	It has been found that amiloride competitively inhibits the catalytic activity of uPA but not tPA.	Amiloride	23-32	plasminogen activator, urokinase	Homo sapiens	82-85
10738907-8	1999	The X-ray structure of the uPA complex with amiloride is not known.	Amiloride	44-53	plasminogen activator, urokinase	Homo sapiens	27-30
10329949-3	1999	The atNHE1 protein, when stably transfected into the NHE-deficient AP-1 cell line (37), demonstrates robust Na+-dependent proton transport that is sensitive to amiloride but not to the potent NHE1 inhibitor HOE-694.	Amiloride	160-169	solute carrier family 9 member C1	Homo sapiens	6-9
10381797-4	1999	Glibenclamide, a known inhibitor of sulfonylurea receptor and cystic fibrosis conductance regulator, induced a dose-dependent and reversible stimulation (of the order of 40-50%) of the amiloride-sensitive current in oocytes expressing Xenopus ENaC, with a K1/2 of 45 +/- 5 microM.	Amiloride	185-194	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	243-247
10458651-0	1999	Characterization of rabbit kidney and brain pancreatic polypeptide-binding neuropeptide Y receptors: differences with Y1 and Y2 sites in sensitivity to amiloride derivatives affecting sodium transport.	Amiloride	152-161	neuropeptide Y	Oryctolagus cuniculus	75-89
10336442-1	1999	Extracellular amiloride inhibits all known DEG/ENaC ion channels, including BNC1, a proton-activated human neuronal cation channel.	Amiloride	14-23	basonuclin 1	Homo sapiens	76-80
10336442-3	1999	Here we demonstrate that, in addition to blocking BNC1, amiloride also exposes residue 430.	Amiloride	56-65	basonuclin 1	Homo sapiens	50-54
10336442-5	1999	To test this hypothesis, we introduced a mutation in the BNC1 pore that reduces amiloride block, and found that amiloride stimulated these channels.	Amiloride	80-89	basonuclin 1	Homo sapiens	57-61
10336442-5	1999	To test this hypothesis, we introduced a mutation in the BNC1 pore that reduces amiloride block, and found that amiloride stimulated these channels.	Amiloride	112-121	basonuclin 1	Homo sapiens	57-61
10336442-7	1999	These data show that amiloride can have two distinct effects on BNC1, and they suggest two different interaction sites.	Amiloride	21-30	basonuclin 1	Homo sapiens	64-68
10388598-1	1999	The diuretic amiloride has been reported to inhibit both Na+-H+ antiport and the urokinase-type plasminogen activator.	Amiloride	13-22	plasminogen activator, urokinase	Gallus gallus	81-117
10354464-3	1999	To study the mechanisms of this downregulation we have measured amiloride-inhibitable Na+ current (Iamil) in oocytes co-expressing rat ENaC and human wild-type CFTR.	Amiloride	64-73	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	135-139
10329949-3	1999	The atNHE1 protein, when stably transfected into the NHE-deficient AP-1 cell line (37), demonstrates robust Na+-dependent proton transport that is sensitive to amiloride but not to the potent NHE1 inhibitor HOE-694.	Amiloride	160-169	solute carrier family 9 member A1	Homo sapiens	6-10
10436405-1	1999	Epidermal growth factor (EGF) inhibits amiloride-sensitive Na(+) conductance in the apical membrane of the isolated rabbit cortical collecting duct.	Amiloride	39-48	pro-epidermal growth factor	Oryctolagus cuniculus	0-23
10395073-8	1999	Thus, AVP directly increased the rate of protein synthesis via the V1 receptor that is sensitive to amiloride, a mechanism that differs from the cAMP-dependent mechanism that is responsible for the cardiac hypertrophy induced by pressure overload.	Amiloride	100-109	arginine vasopressin	Rattus norvegicus	6-9
10212217-1	1999	In airway and renal epithelia, the glucocorticoid-mediated stimulation of amiloride-sensitive Na+ transport is associated with increased expression of the epithelial Na+ channel alpha subunit (alphaENaC).	Amiloride	74-83	sodium channel epithelial 1 subunit alpha	Homo sapiens	166-203
10362847-8	1999	Subsequent addition of amiloride (0.1 mM) reduced the cell conductance to 1558 +/- 33 pS pF-1 (N = 6).	Amiloride	23-32	PHD finger protein 12	Homo sapiens	89-93
10436405-1	1999	Epidermal growth factor (EGF) inhibits amiloride-sensitive Na(+) conductance in the apical membrane of the isolated rabbit cortical collecting duct.	Amiloride	39-48	pro-epidermal growth factor	Oryctolagus cuniculus	25-28
10436405-4	1999	Basolateral EGF depolarized the transepithelial voltage in a dose-dependent manner within a concentration range of 10(-10) in 10(-8) M. Basolateral ouabain and luminal amiloride completely abolished EGF-induced depolarization.	Amiloride	168-177	pro-epidermal growth factor	Oryctolagus cuniculus	12-15
10436405-4	1999	Basolateral EGF depolarized the transepithelial voltage in a dose-dependent manner within a concentration range of 10(-10) in 10(-8) M. Basolateral ouabain and luminal amiloride completely abolished EGF-induced depolarization.	Amiloride	168-177	pro-epidermal growth factor	Oryctolagus cuniculus	199-202
10187795-4	1999	In particular, whereas most members of the amiloride-sensitive Na+ channel/degenerin family are highly selective for Na+ over K+, ASIC3/ASIC2b heteromultimers show a nonselective component.	Amiloride	43-52	acid sensing ion channel subunit 3	Homo sapiens	130-135
10187795-4	1999	In particular, whereas most members of the amiloride-sensitive Na+ channel/degenerin family are highly selective for Na+ over K+, ASIC3/ASIC2b heteromultimers show a nonselective component.	Amiloride	43-52	acid sensing ion channel subunit 2	Homo sapiens	136-141
9950821-3	1999	In acinar cells superfused with a physiological salt solution (145 mM Na+), Na+/H+ exchanger activity was inhibited by low concentrations of the amiloride derivative ethylisopropyl amiloride (EIPA; IC50 = 0.014 +/- 0.005 microM), suggesting the expression of amiloride-sensitive isoforms NHE1 and/or NHE2.	Amiloride	181-190	solute carrier family 9 member A2	Rattus norvegicus	300-304
10092651-1	1999	We previously raised an antibody (RA6.3) by an antiidiotypic approach which was designed to be directed against an amiloride binding domain on the epithelial Na+ channel (ENaC).	Amiloride	115-124	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	171-175
10092651-4	1999	RA6.3 specifically recognized an amiloride binding domain within the alpha-subunit of mouse and bovine ENaC.	Amiloride	33-42	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	103-107
10092651-8	1999	Selected residues docked to the antibody in a manner corresponding to the ordered linear array of amino acid residues within an amiloride binding domain on the alpha-subunit of ENaC.	Amiloride	128-137	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	177-181
10070111-3	1999	Acute intervention with the inducible NO synthase (iNOS)-selective inhibitor S-methylisothiourea resulted in an increase of amiloride-sensitive sodium absorption observed as a hyperpolarization of nasal transepithelial potential difference.	Amiloride	124-133	nitric oxide synthase 2, inducible	Mus musculus	28-49
10070111-3	1999	Acute intervention with the inducible NO synthase (iNOS)-selective inhibitor S-methylisothiourea resulted in an increase of amiloride-sensitive sodium absorption observed as a hyperpolarization of nasal transepithelial potential difference.	Amiloride	124-133	nitric oxide synthase 2, inducible	Mus musculus	51-55
10070111-4	1999	Inhibition of iNOS expression with dexamethasone also hyperpolarized transepithelial potential difference, but only a portion of this increase proved to be amiloride sensitive.	Amiloride	156-165	nitric oxide synthase 2, inducible	Mus musculus	14-18
9950821-3	1999	In acinar cells superfused with a physiological salt solution (145 mM Na+), Na+/H+ exchanger activity was inhibited by low concentrations of the amiloride derivative ethylisopropyl amiloride (EIPA; IC50 = 0.014 +/- 0.005 microM), suggesting the expression of amiloride-sensitive isoforms NHE1 and/or NHE2.	Amiloride	145-154	solute carrier family 9 member A1	Rattus norvegicus	288-292
9950821-3	1999	In acinar cells superfused with a physiological salt solution (145 mM Na+), Na+/H+ exchanger activity was inhibited by low concentrations of the amiloride derivative ethylisopropyl amiloride (EIPA; IC50 = 0.014 +/- 0.005 microM), suggesting the expression of amiloride-sensitive isoforms NHE1 and/or NHE2.	Amiloride	145-154	solute carrier family 9 member A2	Rattus norvegicus	300-304
10328652-9	1999	The activity was inhibited by amiloride, which is a specific inhibitor for uPA.	Amiloride	30-39	plasminogen activator, urokinase	Homo sapiens	75-78
10028059-1	1999	Amiloride and its derivatives are important tools for studying NHE-1, the ubiquitous isoform of the sodium/hydrogen exchanger protein family.	Amiloride	0-9	solute carrier family 9 member A1	Homo sapiens	63-68
10028059-3	1999	Though it has been shown that sodium ions and amiloride molecules interact at unique regions of the NHE-1 protein, physiological experiments reveal a competitive relationship between the two under some circumstances.	Amiloride	46-55	solute carrier family 9 member A1	Homo sapiens	100-105
9950821-3	1999	In acinar cells superfused with a physiological salt solution (145 mM Na+), Na+/H+ exchanger activity was inhibited by low concentrations of the amiloride derivative ethylisopropyl amiloride (EIPA; IC50 = 0.014 +/- 0.005 microM), suggesting the expression of amiloride-sensitive isoforms NHE1 and/or NHE2.	Amiloride	181-190	solute carrier family 9 member A1	Rattus norvegicus	288-292
9918567-7	1999	In contrast, genistein (a tyrosine kinase inhibitor), amiloride (a Na+/H+ exchangers I and II inhibitor), and wortmannin (a phosphatidylinositol 3-kinase inhibitor) significantly decreased the effect of EGF.	Amiloride	54-63	epidermal growth factor like 1	Rattus norvegicus	203-206
10713865-1	1999	Five years ago, our in vitro and in vivo studies demonstrated for the first time that diuretic agents such as furosemide, hydrochlorothiazide, amiloride, triamterene and spironolactone inhibit carbonic anhydrase (CA) I, II and renal CA IV by a direct mechanism of action.	Amiloride	143-152	carbonic anhydrase 1	Homo sapiens	193-218
9882643-10	1999	During systemic acidosis, apical gill NHE-2 (which is sensitive to external amiloride and low [Na+]) in parallel with a dramatic suppression of basolateral NHE-1 activity enhances net capdelta H+ transfers to the water.	Amiloride	76-85	solute carrier family 9 member A2	Homo sapiens	38-43
9882643-10	1999	During systemic acidosis, apical gill NHE-2 (which is sensitive to external amiloride and low [Na+]) in parallel with a dramatic suppression of basolateral NHE-1 activity enhances net capdelta H+ transfers to the water.	Amiloride	76-85	solute carrier family 9 member A1	Homo sapiens	156-161
10713865-1	1999	Five years ago, our in vitro and in vivo studies demonstrated for the first time that diuretic agents such as furosemide, hydrochlorothiazide, amiloride, triamterene and spironolactone inhibit carbonic anhydrase (CA) I, II and renal CA IV by a direct mechanism of action.	Amiloride	143-152	carbonic anhydrase 4	Homo sapiens	233-238
10499877-2	1999	PKA inhibitors (H8, H89 and H7) stimulated amiloride-sensitive Na+ transport in the alveolar type II epithelial cells.	Amiloride	43-52	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	0-3
9886489-2	1999	Amiloride-sensitive NHE-1 is generally identified in the basolateral membrane.	Amiloride	0-9	solute carrier family 9 member A1	Homo sapiens	20-25
9886489-3	1999	The renal cell line, OK7a, targets amiloride-resistant NHE predominantly to the apical membrane.	Amiloride	35-44	solute carrier family 9 member C1	Homo sapiens	55-58
9886489-12	1999	NHE activities were predominant in the apical membrane and those in both membranes were resistant to amiloride analogs.	Amiloride	101-110	solute carrier family 9 member C1	Homo sapiens	0-3
9914284-6	1999	Amiloride and omega-conotoxin GVIA, but not nimodipine, were able to eliminate the neurotensin-induced decrease in IBa.	Amiloride	0-9	neurotensin	Rattus norvegicus	83-94
9843867-10	1998	Amiloride also reduced the ARNA response to renal pelvic administration of substance P, a mediator of the ARNA response to increased renal pelvic pressure.	Amiloride	0-9	tachykinin precursor 1	Homo sapiens	75-86
9882597-11	1999	BEAS-2B cells, pretreated with amiloride before ROFA exposure, showed a partial (approximately 25%) reduction of IL-6.	Amiloride	31-40	interleukin 6	Homo sapiens	113-117
9843758-6	1998	In HCO-3-CO2free medium and in the presence of apical amiloride, pHi recovery from an acid load was Na+ dependent and was inhibited by basolateral amiloride and by HOE-642 (10 microM), consistent with basolateral localization of the NHE1 isoform, which had clearly expressed mRNA.	Amiloride	54-63	glucose-6-phosphate isomerase	Rattus norvegicus	65-68
9843758-6	1998	In HCO-3-CO2free medium and in the presence of apical amiloride, pHi recovery from an acid load was Na+ dependent and was inhibited by basolateral amiloride and by HOE-642 (10 microM), consistent with basolateral localization of the NHE1 isoform, which had clearly expressed mRNA.	Amiloride	54-63	solute carrier family 9 member A1	Rattus norvegicus	233-237
9806987-10	1998	Measurement of the inhibition of NHE activity by the amiloride analogue HOE 694 (HOE) suggested expression of NHE1-like activity in the BLM and NHE2-like activity in the LM of the SMG duct.	Amiloride	53-62	solute carrier family 9 member A1	Rattus norvegicus	110-114
9843758-6	1998	In HCO-3-CO2free medium and in the presence of apical amiloride, pHi recovery from an acid load was Na+ dependent and was inhibited by basolateral amiloride and by HOE-642 (10 microM), consistent with basolateral localization of the NHE1 isoform, which had clearly expressed mRNA.	Amiloride	147-156	glucose-6-phosphate isomerase	Rattus norvegicus	65-68
9843758-7	1998	Apical Na+ readmission induced a slow pHi recovery that was inhibited by apical administration of 1 mM HOE-642 or amiloride.	Amiloride	114-123	glucose-6-phosphate isomerase	Rattus norvegicus	38-41
9806987-10	1998	Measurement of the inhibition of NHE activity by the amiloride analogue HOE 694 (HOE) suggested expression of NHE1-like activity in the BLM and NHE2-like activity in the LM of the SMG duct.	Amiloride	53-62	solute carrier family 9 member A2	Rattus norvegicus	144-148
9820376-7	1998	Notably, the rate of recovery was faster the more acidic the pHi, and recovery was abolished by amiloride or replacement with an Na+-free buffer.	Amiloride	96-105	glucose-6-phosphate isomerase	Homo sapiens	61-64
9825309-0	1998	Competitive inhibition of Lens culinaris L. copper amine oxidase by amiloride, p-aminobenzamidine, clonidine, 4",6-diamidino-2-phenylindole and gabexate mesylate: a comparative study.	Amiloride	68-77	amine oxidase copper containing 3	Homo sapiens	44-64
9829357-7	1998	In HCO3--free media, pHi recovery after acidification with NH4Cl was amiloride-sensitive and Na+-dependent, indicating the presence of an Na+/H+ exchanger.	Amiloride	69-78	glucose-6-phosphate isomerase	Homo sapiens	21-24
9799395-3	1998	XL-NHE activity was inhibited by amiloride, ethylisopropylamiloride, HOE694 [(3-methylsulphonyl-4-piperidinobenzoyl)-guanidine methanesulphonate] and HOE642 [4-isopropyl-3-methylsulphonylbenzoyl)-guanidine methanesulphonate], Ki values being calculated at 5 micromol/l, 25 nmol/l, 300 nmol/l and 180 nmol/l, respectively.	Amiloride	33-42	solute carrier family 9 member 1 S homeolog	Xenopus laevis	3-6
9755109-12	1998	In contrast, the cell-permeable superoxide scavenger tetramethylpiperidine-N-oxyl (TEMPO) eliminated the O2-induced increases in amiloride-sensitive Isc and ENaC mRNA levels.	Amiloride	129-138	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	157-161
9716715-4	1998	In contrast, amiloride is a weak NHE3 inhibitor (IC50>100 micromol/l) with a higher affinity to hNHE1 and rbNHE2.	Amiloride	13-22	solute carrier family 9 member A3	Homo sapiens	33-37
9716715-4	1998	In contrast, amiloride is a weak NHE3 inhibitor (IC50>100 micromol/l) with a higher affinity to hNHE1 and rbNHE2.	Amiloride	13-22	solute carrier family 9 member A1	Homo sapiens	99-104
9825309-2	1998	However, values of Ki for amiloride and gabexate mesylate binding to swine kidney copper amine oxidase are lower than those observed for inhibitor binding to Lens culinaris L. cooper amine oxidase.	Amiloride	26-35	amine oxidase copper containing 3	Homo sapiens	82-102
9825309-3	1998	Thus, amiloride and gabexate mesylate may represent useful model compounds for the development of selective inhibitors of mammalian copper amine oxidase, which may be important in view of the potential use of plant copper amine oxidase as drugs.	Amiloride	6-15	amine oxidase copper containing 3	Homo sapiens	132-152
9825309-3	1998	Thus, amiloride and gabexate mesylate may represent useful model compounds for the development of selective inhibitors of mammalian copper amine oxidase, which may be important in view of the potential use of plant copper amine oxidase as drugs.	Amiloride	6-15	amine oxidase copper containing 3	Homo sapiens	215-235
9821105-3	1998	Intracellular pH (pHi) is regulated mainly by Na+/H+ and HCO3-/Cl- antiports through the cell membrane, and amiloride acts on the former, DIDS on the latter to lower pHi.	Amiloride	108-117	glucose-6-phosphate isomerase	Homo sapiens	18-21
9821105-3	1998	Intracellular pH (pHi) is regulated mainly by Na+/H+ and HCO3-/Cl- antiports through the cell membrane, and amiloride acts on the former, DIDS on the latter to lower pHi.	Amiloride	108-117	glucose-6-phosphate isomerase	Homo sapiens	166-169
9821105-11	1998	The pHi of the cells heated in the presence of amiloride was decreased to 6.83.	Amiloride	47-56	glucose-6-phosphate isomerase	Homo sapiens	4-7
9665481-7	1998	Cell motility is significantly reduced by inhibitors of u-PA proteolytic activity such as antibodies neutralizing u-PA activity, plasminogen activator inhibitor 1, and amiloride.	Amiloride	168-177	plasminogen activator, urokinase	Homo sapiens	56-60
9821105-12	1998	The pHi was further lowered to 6.67 by the treatment with amiloride in combination with DIDS for 2 hours.	Amiloride	58-67	glucose-6-phosphate isomerase	Homo sapiens	4-7
9707631-2	1998	Two proton-gated channels, acid-sensing ionic channel (ASIC) and dorsal root ASIC (DRASIC), that are members of the amiloride-sensitive ENaC/Degenerin family are known to be expressed by sensory neurons.	Amiloride	116-125	acid sensing ion channel subunit 3	Rattus norvegicus	65-81
9707631-2	1998	Two proton-gated channels, acid-sensing ionic channel (ASIC) and dorsal root ASIC (DRASIC), that are members of the amiloride-sensitive ENaC/Degenerin family are known to be expressed by sensory neurons.	Amiloride	116-125	acid sensing ion channel subunit 3	Rattus norvegicus	83-89
9794723-4	1998	METHODS: NHE was measured as maximal initial rate (Vmax) of amiloride-inhibited efflux of H+ into an alkaline Na+-containing medium, for 47 patients with hypercortisolism (20 with pituitary adenomas, 18 with adrenal adenomas, and nine with ectopic production of adrenocorticotropin).	Amiloride	60-69	solute carrier family 9 member C1	Homo sapiens	9-12
9685633-0	1998	Identification and expression of the Na+/H+ exchanger in mammalian cerebrovascular and choroidal tissues: characterization by amiloride-sensitive [3H]MIA binding and RT-PCR analysis.	Amiloride	126-135	solute carrier family 9 member C1	Homo sapiens	37-53
9685633-7	1998	These binding results were most compatible with the existence of the amiloride-sensitive NHE type 1 in the brain vascular and choroidal tissues.	Amiloride	69-78	solute carrier family 9 member C1	Homo sapiens	89-92
9685633-11	1998	Our study suggests that mammalian cerebrovascular and choroidal tissues contain high amounts of the ubiquitous amiloride-sensitive [3H]MIA binding proteins consistent with the expression of NHE type 1 mRNA.	Amiloride	111-120	solute carrier family 9 member C1	Homo sapiens	190-193
9674649-1	1998	Mutations of the last exon of the beta subunit of the amiloride-sensitive epithelial Na+ channel (betaENaC) can lead to Liddle"s syndrome, a rare monogenic form of hypertension.	Amiloride	54-63	sodium channel, non voltage gated 1 beta subunit S homeolog	Xenopus laevis	98-106
9649552-0	1998	The amiloride-inhibitable Na+ conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways.	Amiloride	4-13	CF transmembrane conductance regulator	Homo sapiens	60-111
9609738-0	1998	Regulation of amiloride-sensitive sodium absorption in murine airway epithelium by C-type natriuretic peptide.	Amiloride	14-23	natriuretic peptide type C	Mus musculus	83-109
9655835-7	1998	The LPC-induced increase in [Ca++]i was attenuated significantly by the inhibitors of Na(+)-Ca++ exchanger such as Ni++ and amiloride.	Amiloride	124-133	solute carrier family 8 member A1	Rattus norvegicus	86-106
9625839-5	1998	In vitro analysis of the ability of amiloride to inhibit invasion of MLL cells demonstrated that this drug was ineffective at all concentrations examined.	Amiloride	36-45	lysine methyltransferase 2A	Rattus norvegicus	69-72
9609744-3	1998	We found in both control and silica-treated animals that amiloride almost totally abolished PA activity in bronchoalveolar lavage (BAL) fluid (BALF), indicating that initial upregulation (from day 1) as well as sustained PA activity (up to day 30) observed in response to silica is related to changes in urokinase-type PA (uPA).	Amiloride	57-66	plasminogen activator, urokinase	Mus musculus	304-321
9609744-3	1998	We found in both control and silica-treated animals that amiloride almost totally abolished PA activity in bronchoalveolar lavage (BAL) fluid (BALF), indicating that initial upregulation (from day 1) as well as sustained PA activity (up to day 30) observed in response to silica is related to changes in urokinase-type PA (uPA).	Amiloride	57-66	plasminogen activator, urokinase	Mus musculus	323-326
9609738-2	1998	In this paper, we show that CNP is also capable of reducing amiloride-sensitive sodium absorption in murine airway epithelium through a cGMP-dependent mechanism that is separate from the CFTR regulatory signaling pathway.	Amiloride	60-69	natriuretic peptide type C	Mus musculus	28-31
9609738-3	1998	Both murine tracheal and nasal tissues exhibit sensitivity to amiloride-sensitive sodium regulation by exogenously added CNP.	Amiloride	62-71	natriuretic peptide type C	Mus musculus	121-124
9516235-8	1998	The Na-H exchanger inhibitor amiloride (1 mM) reduced pHi 0.52 +/- 0.10 pH units.	Amiloride	29-38	glucose-6-phosphate isomerase	Oryctolagus cuniculus	54-57
9600998-6	1998	In oocytes expressing the colonic H,K-ATPase, the decrease in intracellular Na+ activity persists when diffusive Na+ influx is enhanced by functional expression of the amiloride-sensitive epithelial Na+ channel, suggesting that the decrease is related to increased active Na+ efflux.	Amiloride	168-177	ATPase Na+/K+ transporting subunit alpha 1 L homeolog	Xenopus laevis	36-44
9612225-4	1998	We have used a noninvasive pulse protocol of blocker-induced noise analysis to determine changes in single-channel current (iNa), channel open probability (Po), and functional channel density (NT) of amiloride-sensitive ENaCs at various time points following treatment with insulin for 3 h of unstimulated control and aldosterone-pretreated A6 epithelia.	Amiloride	200-209	insulin	Homo sapiens	274-281
9612230-5	1998	When incubated at 18 degrees C with SIN-1 (1 mM) for 2 h (final ONOO- concentration = 10 microM), the amiloride-sensitive conductance was reduced to 0.8 +/- 0.5 microS.	Amiloride	102-111	MAPK associated protein 1 L homeolog	Xenopus laevis	36-41
9626814-1	1998	Amiloride is an inhibitor of urokinase plasminogen activator (uPA), an essential component of the plasminogen/plasmin enzyme system.	Amiloride	0-9	plasminogen activator, urokinase	Rattus norvegicus	29-60
9626814-1	1998	Amiloride is an inhibitor of urokinase plasminogen activator (uPA), an essential component of the plasminogen/plasmin enzyme system.	Amiloride	0-9	plasminogen activator, urokinase	Rattus norvegicus	62-65
9584219-0	1998	Characterization of the allosteric interactions between antagonists and amiloride analogues at the human alpha2A-adrenergic receptor.	Amiloride	72-81	adrenoceptor alpha 2A	Homo sapiens	105-132
9575821-1	1998	Insulin stimulates amiloride-sensitive sodium transport in models of the distal nephron.	Amiloride	19-28	insulin	Homo sapiens	0-7
9547389-5	1998	Macroscopic amiloride-sensitive currents (INa) were measured by conventional whole-cell clamp.	Amiloride	12-21	internexin neuronal intermediate filament protein, alpha	Rattus norvegicus	42-45
9612219-14	1998	The cRNA for each alpha-ENaC transcript when combined with beta- and gamma-ENaC cRNA reconstituted a low-conductance ion channel with amiloride-sensitive currents of similar characteristics.	Amiloride	134-143	sodium channel epithelial 1 subunit alpha	Homo sapiens	18-28
9547511-6	1998	As indicated by zymography and the use of amiloride in the PA assay, the activity in the medium was primarily urokinase-type plasminogen activator (uPA).	Amiloride	42-51	plasminogen activator, urokinase	Rattus norvegicus	110-146
9479012-5	1998	The microscopic parameters underlying INa, namely the single-channel current (i) and the open channel density (No), were investigated by the analysis of current fluctuations induced by the electroneutral amiloride analogue CDPC (6-chloro-3, 5-diaminopyrazine-2-carboxamide).	Amiloride	204-213	internexin neuronal intermediate filament protein alpha	Homo sapiens	38-41
9516235-9	1998	In the presence of DBI, the magnitude of pHi reduction caused by amiloride was significantly (P < 0.05) reduced to 0.26 +/- 0.09 pH units.	Amiloride	65-74	acyl-CoA-binding protein	Oryctolagus cuniculus	19-22
9516235-9	1998	In the presence of DBI, the magnitude of pHi reduction caused by amiloride was significantly (P < 0.05) reduced to 0.26 +/- 0.09 pH units.	Amiloride	65-74	glucose-6-phosphate isomerase	Oryctolagus cuniculus	41-44
9516235-11	1998	DBI also reduced by approximately 40% the rate of pHi recovery in cells acidified by an ammonium chloride (20 mM) prepulse; a reduction in pHi recovery rate was also caused by ACTZ and amiloride.	Amiloride	185-194	acyl-CoA-binding protein	Oryctolagus cuniculus	0-3
9516235-11	1998	DBI also reduced by approximately 40% the rate of pHi recovery in cells acidified by an ammonium chloride (20 mM) prepulse; a reduction in pHi recovery rate was also caused by ACTZ and amiloride.	Amiloride	185-194	glucose-6-phosphate isomerase	Oryctolagus cuniculus	139-142
9428699-6	1997	We have shown previously that amiloride blocks erythropoietin-enhanced proliferation of J2E cells, but potentiates maturation [Callus, B.	Amiloride	30-39	erythropoietin	Mus musculus	47-61
9476862-10	1998	Subjects in the 4PBA group demonstrated small, but statistically significant improvements of the NPD response to perfusion of an isoproterenol/amiloride/chloride-free solution; this measure reflects epithelial CFTR function and is highly discriminatory between patients with and without CF.	Amiloride	143-152	CF transmembrane conductance regulator	Homo sapiens	210-214
9458082-6	1998	Immunofluorescent detection and quantitation of cyclin B1 expression demonstrated that amiloride only significantly reduced cyclin B1 expression following 5.0 Gy, when there was a notable induction of a significant G2 delay, followed by a relatively rapid recovery in cycling potential.	Amiloride	87-96	cyclin B1	Homo sapiens	48-57
9458082-6	1998	Immunofluorescent detection and quantitation of cyclin B1 expression demonstrated that amiloride only significantly reduced cyclin B1 expression following 5.0 Gy, when there was a notable induction of a significant G2 delay, followed by a relatively rapid recovery in cycling potential.	Amiloride	87-96	cyclin B1	Homo sapiens	124-133
9458082-7	1998	The results suggest that amiloride affects the radiation-triggered signaling cascades to alter the kinase activity of proteins associated with mitotic progression, particularly the cyclin B1-p34cdc2 complex.	Amiloride	25-34	cyclin B1	Homo sapiens	181-190
11324523-5	1998	Pretreatment of amiloride (10(-4) mol/L), a Na(+)-H+ exchange inhibitor completely inhibited the ET-1-induced, but not PMA-induced cardiomyocyte hypertrophic responses.	Amiloride	16-25	endothelin 1	Rattus norvegicus	97-101
9458827-7	1998	Together, these data demonstrate that ENaC is expressed in the mammalian urinary bladder and suggest that amiloride-sensitive Na+ transport across the apical membrane of the mammalian urinary bladder epithelium is mediated primarily by ENaC.	Amiloride	106-115	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	38-42
9458827-7	1998	Together, these data demonstrate that ENaC is expressed in the mammalian urinary bladder and suggest that amiloride-sensitive Na+ transport across the apical membrane of the mammalian urinary bladder epithelium is mediated primarily by ENaC.	Amiloride	106-115	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	236-240
10729770-2	1998	The inhibition of uPA with amiloride or B428 has been shown to be dose dependent.	Amiloride	27-36	plasminogen activator, urokinase	Rattus norvegicus	18-21
9422083-0	1998	Inhibitory effect of amiloride on the urokinase plasminogen activators in prostatic cancer.	Amiloride	21-30	plasminogen activator, urokinase	Rattus norvegicus	38-70
9422083-1	1998	The diuretic drug amiloride (AMLD), which competitively inhibits the catalytic activity of urokinase plasminogen activators (UPA), was used to study its effects on the proteolytic enzymes implicated in the invasiveness and metastases in a prostatic tumor model carrying two different sublines of adenocarcinoma of the prostate.	Amiloride	18-27	plasminogen activator, urokinase	Rattus norvegicus	91-123
9422083-1	1998	The diuretic drug amiloride (AMLD), which competitively inhibits the catalytic activity of urokinase plasminogen activators (UPA), was used to study its effects on the proteolytic enzymes implicated in the invasiveness and metastases in a prostatic tumor model carrying two different sublines of adenocarcinoma of the prostate.	Amiloride	18-27	plasminogen activator, urokinase	Rattus norvegicus	125-128
9493127-5	1998	Acid loading followed by washout resulted in an amiloride-sensitive return to the (temperature dependent) basal pHi.	Amiloride	48-57	glucose-6-phosphate isomerase	Homo sapiens	112-115
9425162-5	1998	Amiloride and gadolinium, which block mechanosensation in vivo, inhibited RPK channels.	Amiloride	0-9	ripped pocket	Drosophila melanogaster	74-77
9510946-1	1998	The action of amiloride on two different components of airway electrical potential difference, one stable (PD) and the other transiently hyperpolarizable after gentle mechanical stimulation (dPD), was studied by means of isolated tracheal wall mounted in a modified Ussing apparatus.	Amiloride	14-23	dachs	Drosophila melanogaster	107-109
9510946-1	1998	The action of amiloride on two different components of airway electrical potential difference, one stable (PD) and the other transiently hyperpolarizable after gentle mechanical stimulation (dPD), was studied by means of isolated tracheal wall mounted in a modified Ussing apparatus.	Amiloride	14-23	dachs	Drosophila melanogaster	191-194
9510946-2	1998	The immediate effect of amiloride, when added to the bathing and stimulating medium, was a partial depolarization, and a diminution or elimination of dPD.	Amiloride	24-33	dachs	Drosophila melanogaster	150-153
9510946-3	1998	After at least 60 min incubation of the tracheal wall with amiloride in the presence of the drug in the bathing and stimulating fluid, both the PD, and dPD were no different from the control.	Amiloride	59-68	dachs	Drosophila melanogaster	144-146
9510946-3	1998	After at least 60 min incubation of the tracheal wall with amiloride in the presence of the drug in the bathing and stimulating fluid, both the PD, and dPD were no different from the control.	Amiloride	59-68	dachs	Drosophila melanogaster	152-155
9510946-4	1998	This difference between the immediate and the sustained action of amiloride on airway PD suggests that there is an efficient regulatory system in the airway walls which stabilizes the transepithelial PD.	Amiloride	66-75	dachs	Drosophila melanogaster	86-88
9510946-4	1998	This difference between the immediate and the sustained action of amiloride on airway PD suggests that there is an efficient regulatory system in the airway walls which stabilizes the transepithelial PD.	Amiloride	66-75	dachs	Drosophila melanogaster	200-202
9417140-1	1998	We have investigated the effect of extracellular proteases on the amiloride-sensitive Na+ current (INa) in Xenopus oocytes expressing the three subunits alpha, beta, and gamma of the rat or Xenopus epithelial Na+ channel (ENaC).	Amiloride	66-75	internexin neuronal intermediate filament protein alpha S homeolog	Xenopus laevis	99-102
9500296-9	1998	Amiloride (an inhibitor of Na+ transporters including the Na+/H+ exchanger) also suppressed TNF-alpha release but displayed a time course of action different from the acidic pHo or bafilomycin.	Amiloride	0-9	tumor necrosis factor	Oryctolagus cuniculus	92-101
9435494-2	1997	Expression of alpha-ENaC alone produced small amiloride-sensitive currents (-43 +/- 10 nA, n = 7).	Amiloride	46-55	sodium channel epithelial 1 subunit alpha	Homo sapiens	14-24
9435494-7	1997	Injection of a 30-amino acid peptide with sequence identity to the COOH terminus of the human beta-ENaC significantly reduced the amiloride-sensitive currents by 40-50%.	Amiloride	130-139	sodium channel epithelial 1 subunit beta	Homo sapiens	94-103
9428699-11	1997	Here we demonstrate that amiloride suppressed the hormone-induced increase in transferrin receptors, whereas the enhanced incorporation of iron into haem was not inhibited.	Amiloride	25-34	transferrin	Mus musculus	78-89
9392872-7	1997	We have substantiated this possibility by using Northern analysis to identify in human ciliary body RNA a 3.7-kb transcript corresponding to the alpha-subunit of the amiloride-sensitive, alpha beta gamma-ENaC epithelial sodium channel.	Amiloride	166-175	sodium channel epithelial 1 subunit gamma	Homo sapiens	198-208
9347320-0	1997	Competitive and silent antagonism of recombinant 5-HT1B receptors by amiloride.	Amiloride	69-78	5-hydroxytryptamine receptor 1B	Cricetulus griseus	49-55
9425602-7	1997	Inhibition kinetics of NHE1 by amiloride, 5-(N,N-dimethyl)amiloride (DMA), 5-(N-hexamethyl)amiloride (HMA) and 5-(N-ethyl-N-isopropyl)amiloride (EIPA) were largely unchanged.	Amiloride	31-40	solute carrier family 9 member A1	Homo sapiens	23-27
9425602-8	1997	Half-maximal inhibition of NHE3 was also reached at approximately the same concentrations of amiloride and analogues in control and benzyl alcohol treated, suggesting that the amiloride binding site was unaffected.	Amiloride	93-102	solute carrier family 9 member A3	Homo sapiens	27-31
9453461-12	1997	Moreover, NPY caused a 22Na+ influx into the cells of about 1.6-fold over the basal value which was inhibited by amiloride and 5-(N,N-dimethyl)-amiloride, known Na+/Ca2+ exchange inhibitors.	Amiloride	113-122	neuropeptide Y	Rattus norvegicus	10-13
9388483-0	1997	Angiotensin II mediates cell hypertrophy in vascular smooth muscle cultures from hypertensive Ren-2 transgenic rats by an amiloride- and furosemide-sensitive mechanism.	Amiloride	122-131	angiotensinogen	Rattus norvegicus	0-14
9388483-3	1997	In both SD- and TGR-VSMC, AII increased both cell size, by a furosemide- and amiloride-sensitive mechanism, and Na+/K+/2Cl- cotransport activity, by an amiloride-sensitive mechanism.	Amiloride	77-86	angiotensinogen	Rattus norvegicus	26-29
9388483-3	1997	In both SD- and TGR-VSMC, AII increased both cell size, by a furosemide- and amiloride-sensitive mechanism, and Na+/K+/2Cl- cotransport activity, by an amiloride-sensitive mechanism.	Amiloride	152-161	angiotensinogen	Rattus norvegicus	26-29
9374847-3	1997	In contrast, intracellular pH (pHi) recovery after removing luminal NH4+ was unaffected by bumetanide and Ba2+ but was sensitive to 1 mM luminal amiloride (71% inhibition).	Amiloride	145-154	glucose-6-phosphate isomerase	Oryctolagus cuniculus	31-34
9359905-5	1997	As judged by the effects of HCO3- omission, 100 microM 4,4"-diisothiocyanatostilbene-2,2"-disulphonic acid (DIDS) and 1 mM amiloride, the initial rise in pHi was due to Cl-/HCO3- exchange while the secondary rise resulted from activation of Na+/H+ exchange.	Amiloride	123-132	glucose-6-phosphate isomerase	Rattus norvegicus	154-157
9360943-5	1997	Moreover, coexpression of ASIC and MDEG subunits in Xenopus oocytes generates an amiloride-sensitive H+-gated Na+ channel with novel properties (different kinetics, ionic selectivity, and pH sensitivity).	Amiloride	81-90	acid sensing ion channel subunit 1	Homo sapiens	26-30
9360943-5	1997	Moreover, coexpression of ASIC and MDEG subunits in Xenopus oocytes generates an amiloride-sensitive H+-gated Na+ channel with novel properties (different kinetics, ionic selectivity, and pH sensitivity).	Amiloride	81-90	acid sensing ion channel subunit 2	Homo sapiens	35-39
9360571-0	1997	Rapid life-threatening hyperkalemia after addition of amiloride HCl/hydrochlorothiazide to angiotensin-converting enzyme inhibitor therapy.	Amiloride	54-67	angiotensin I converting enzyme	Homo sapiens	91-120
9407593-2	1997	Coadministration of amiloride increases the incidence and severity of acetazolamide-induced forelimb malformations and further reduces limb bud pHi.	Amiloride	20-29	glucose-6-phosphate isomerase 1	Mus musculus	144-147
9316428-2	1997	Amiloride sensitivity of the Na(+)-dependent intracellular pH (pHi) recovery in suspended tubules that had been acid loaded by an NH4+ prepulse was determined in nominally CO2/HCO3(-)-free solution, using the fluorescent pH-sensitive dye 2",7"-bis(carboxyethyl)-5(6)-carboxyfluorescein.	Amiloride	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	63-66
9316428-3	1997	In the presence of 140 mM extracellular Na+, 800 microM amiloride inhibited the rate of Na(+)-dependent pHi recovery by only 65%, demonstrating the presence of a Na(+)-dependent amiloride-insensitive H+ extrusion system.	Amiloride	56-65	glucose-6-phosphate isomerase	Rattus norvegicus	104-107
9316428-3	1997	In the presence of 140 mM extracellular Na+, 800 microM amiloride inhibited the rate of Na(+)-dependent pHi recovery by only 65%, demonstrating the presence of a Na(+)-dependent amiloride-insensitive H+ extrusion system.	Amiloride	178-187	glucose-6-phosphate isomerase	Rattus norvegicus	104-107
9316428-5	1997	Lowering extracellular Na+ concentration permitted 300 microM amiloride to completely inhibit Na(+)-dependent pHi recovery.	Amiloride	62-71	glucose-6-phosphate isomerase	Rattus norvegicus	110-113
9316428-9	1997	These results strongly suggest that amiloride-insensitive Na+/H+ exchange expressed in renal cortical tubule suspensions is mediated by NHE4.	Amiloride	36-45	solute carrier family 9 member A4	Rattus norvegicus	136-140
9252507-3	1997	In the absence of HCO3-, baseline pHi was significantly higher (P < 0.001) in activated than in nonactivated HSC (7.1 +/- 0.1 vs. 6.9 +/- 0.2) and decreased, in both groups, after amiloride administration and after Na+ removal.	Amiloride	183-192	glucose-6-phosphate isomerase	Rattus norvegicus	34-37
9501924-10	1997	Our data indicate that the Na+/H+ exchanger is involved in this process, since acid load and pHi-recovery experiments showed the alkalization to be amiloride-sensitive.	Amiloride	148-157	glucose-6-phosphate isomerase 1	Mus musculus	93-96
9252507-6	1997	Amiloride and Na+ removal inhibited pHi recovery after an intracellular acid load by 77 and 93%, respectively, in nonactivated and by 82 and 92%, respectively, in activated HSC, whereas 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid inhibited pHi recovery by only 27%.	Amiloride	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	36-39
9311495-6	1997	Patients with apical CFTR protein showed higher residual chloride secretion than those without (amiloride to isoprenaline value of 4.59 and 0.56 mV, respectively, p = 0.01).	Amiloride	96-105	CF transmembrane conductance regulator	Homo sapiens	21-25
9338142-3	1997	This response was inhibited by the amiloride analogue, methyisobutylamiloride, demonstrating that activation of the Na+/H+ antiport was responsible for the increase in baseline pHi and the recovery from acidosis.	Amiloride	35-44	glucose-6-phosphate isomerase	Homo sapiens	177-180
9249582-6	1997	All pHi recovery in the four areas studied was inhibited by 1 mM amiloride and unaffected by 0.5 mM 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid.	Amiloride	65-74	glucose-6-phosphate isomerase	Rattus norvegicus	4-7
9252507-4	1997	After an acid-loading maneuver, pHi recovery was significantly higher (P < 0.03) in activated than in nonactivated HSC (H+ flux = 11.0 +/- 3.8 vs. 7.7 +/- 2.9 mM/min at pHi 6.6) and was inhibited by amiloride and Na+ removal.	Amiloride	202-211	glucose-6-phosphate isomerase	Rattus norvegicus	32-35
9252507-6	1997	Amiloride and Na+ removal inhibited pHi recovery after an intracellular acid load by 77 and 93%, respectively, in nonactivated and by 82 and 92%, respectively, in activated HSC, whereas 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid inhibited pHi recovery by only 27%.	Amiloride	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	245-248
9252507-11	1997	Our results show that 1) the Na+/H+ exchanger is the main pHi regulator in rat HSC, 2) activation of HSC is associated with an increase in pHi and in the activity of the Na+/H+ exchanger, 3) PDGF increases the activity of this exchanger, and 4) amiloride is able to inhibit HSC proliferation induced by PDGF.	Amiloride	245-254	solute carrier family 9 member A3	Rattus norvegicus	170-189
9252507-5	1997	In the presence of HCO3-, baseline pHi was higher in both groups and decreased after amiloride administration.	Amiloride	85-94	glucose-6-phosphate isomerase	Rattus norvegicus	35-38
9283063-4	1997	Amiloride-sensitive 22Na uptake was measured in platelets which had been acid loaded, to stimulate NHE, by suspension in isotonic potassium propionate buffer (pH 6.7).	Amiloride	0-9	solute carrier family 9 member C1	Homo sapiens	99-102
9298595-5	1997	Amiloride (1 mM) of 5-(N-ethyl-N-isopropyl)-amiloride (10 microM), two previously reported inhibitors of the Na+/H+ exchangers, mimicked the effects produced by 2H2O on pHi and PtdCho turnover.	Amiloride	0-9	glucose-6-phosphate isomerase 1	Mus musculus	169-172
9259181-2	1997	NHE1, ubiquitously expressed, amiloride-sensitive and growth factor-activatable, is present in the basolateral membrane of most segments of the renal tubule.	Amiloride	30-39	solute carrier family 9 member A1	Homo sapiens	0-4
9180901-2	1997	LLC-PK1 clone 4 (CL4) expresses the amiloride-sensitive type of NHE predominantly in the basolateral membrane, which is believed to be NHE-1.	Amiloride	36-45	solute carrier family 9 member A2	Sus scrofa	64-67
9207248-6	1997	The pHi of osteoclasts cultured on glass responded to the addition of amiloride, but was not effected by even high concentrations of bafilomycin A1.	Amiloride	70-79	glucose-6-phosphate isomerase	Rattus norvegicus	4-7
9180901-2	1997	LLC-PK1 clone 4 (CL4) expresses the amiloride-sensitive type of NHE predominantly in the basolateral membrane, which is believed to be NHE-1.	Amiloride	36-45	sodium/hydrogen exchanger 1	Sus scrofa	135-140
9159181-6	1997	These data indicate that the gamma (and/or gamma2) subunit participates in amiloride binding and the sensing of the extracellular sodium concentration.	Amiloride	75-84	tryptophanyl-tRNA synthetase 1 L homeolog	Xenopus laevis	43-49
9153215-10	1997	The addition of amiloride or the omission of Na+, which were verified to inhibit NHE, did not prevent the osmotically induced activation of SAPK.	Amiloride	16-25	solute carrier family 9 member C1	Homo sapiens	81-84
9096607-6	1997	In the absence of HCO3-, pHi recovery from an intracellular acid load (ammonia pre-pulse technique) was Na(+)-dependent and amiloride-inhibitable.	Amiloride	124-133	glucose-6-phosphate isomerase	Homo sapiens	25-28
9094251-5	1997	Incubating the apical side of the epithelium with either amiloride or Na+-free solutions also reduced or abolished the increase in the initial rate of [3H]ouabain binding caused by insulin.	Amiloride	57-66	insulin	Homo sapiens	181-188
9094252-7	1997	However, amiloride had a significant lower affinity in CF tissue (half-maximal blocker concentration, K1/2 = 586 +/- 59 nM) compared with non-CF tissue (K1/2 = 294 +/- 22 nM).	Amiloride	9-18	keratin 1	Homo sapiens	102-112
9154341-8	1997	The blockade of the Na(+)-Ca2+ exchanger by the amiloride derivative 5-(N-4-chlorobenzyl)-2",4"-dimethylbenzamil (CB-DMB), lanthanum (La3+) and the Ca2+ chelator EGTA, completely reverted the protective effect exerted by the removal of Na+ ions on C6 glioma cells exposed to chemical hypoxia.	Amiloride	48-57	solute carrier family 8 member A1	Homo sapiens	20-40
9084415-4	1997	Both CNP and amiloride analogues inhibited the Na(+)-dependent pHi recovery, even in the nominal absence of CO2/HCO3-.	Amiloride	13-22	glucose-6-phosphate isomerase	Rattus norvegicus	63-66
9084968-4	1997	In this study NHE as initial velocity of amiloride-inhibited H+ efflux from erythrocytes (pHi 6.35-6.45) into an Na(+)-containing medium (pHo 7.95-8.05), was estimated during 8 years of follow-up in 138 non-microalbuminuric diabetic patients (74 women, 64 men, age 52 +/- 4 years) treated with antihyperglycaemic drugs for 14 +/- 2 years.	Amiloride	41-50	solute carrier family 9 member C1	Homo sapiens	14-17
9062125-2	1997	Using acute intracellular acidifications in the presence of the NHE-1 inhibitor amiloride (300 microM), we selected a clone expressing a NHE-1 protein exhibiting a 3.3-fold increase in K(i) for amiloride (10 microM instead of 3 microM).	Amiloride	80-89	solute carrier family 9 member A1	Homo sapiens	64-69
9062125-2	1997	Using acute intracellular acidifications in the presence of the NHE-1 inhibitor amiloride (300 microM), we selected a clone expressing a NHE-1 protein exhibiting a 3.3-fold increase in K(i) for amiloride (10 microM instead of 3 microM).	Amiloride	80-89	solute carrier family 9 member A1	Homo sapiens	137-142
9062125-2	1997	Using acute intracellular acidifications in the presence of the NHE-1 inhibitor amiloride (300 microM), we selected a clone expressing a NHE-1 protein exhibiting a 3.3-fold increase in K(i) for amiloride (10 microM instead of 3 microM).	Amiloride	194-203	solute carrier family 9 member A1	Homo sapiens	64-69
9062125-2	1997	Using acute intracellular acidifications in the presence of the NHE-1 inhibitor amiloride (300 microM), we selected a clone expressing a NHE-1 protein exhibiting a 3.3-fold increase in K(i) for amiloride (10 microM instead of 3 microM).	Amiloride	194-203	solute carrier family 9 member A1	Homo sapiens	137-142
9062189-5	1997	Heterologous expression of ASIC induces an amiloride-sensitive cation (Na+ > Ca2+ > K+) channel which is transiently activated by rapid extracellular acidification.	Amiloride	43-52	acid sensing ion channel subunit 1	Homo sapiens	27-31
9056693-2	1997	NHE was measured as the amiloride-inhibited fraction of H+ efflux (V max) from erythrocytes (pHi 6.40 +/- 0.05) into a Na+-containing medium (pHo 8.00 +/- 0.05).	Amiloride	24-33	solute carrier family 9 member C1	Homo sapiens	0-3
9118951-1	1997	Pseudohypoaldosteronism type 1 (PHA-1) is an inherited disease characterized by severe neonatal salt-wasting and caused by mutations in subunits of the amiloride-sensitive epithelial sodium channel (ENaC).	Amiloride	152-161	sodium channel epithelial 1 subunit gamma	Homo sapiens	0-37
8994058-1	1997	In Caenorhabditis elegans necrosis-like neuronal death is induced by gain-of-function (gf) mutations in two genes, mec-4 and deg-1, that encode proteins similar to subunits of the vertebrate amiloride-sensitive epithelial Na+ channel.	Amiloride	191-200	Degenerin mec-4	Caenorhabditis elegans	115-120
8994058-1	1997	In Caenorhabditis elegans necrosis-like neuronal death is induced by gain-of-function (gf) mutations in two genes, mec-4 and deg-1, that encode proteins similar to subunits of the vertebrate amiloride-sensitive epithelial Na+ channel.	Amiloride	191-200	Degenerin deg-1	Caenorhabditis elegans	125-130
9050969-5	1997	By measuring the amiloride-sensitive intracellular pH recovery rate after intracellular acid loading with NH4Cl, we estimated the NHE3 activity.	Amiloride	17-26	solute carrier family 9 member A3	Rattus norvegicus	130-134
9157597-3	1997	Plasminogen activation was markedly reduced by addition of amiloride or of anti-murine u-PA antibodies but not by addition of anti-murine t-PA antibodies, and it was not stimulated by addition of fibrin.	Amiloride	59-68	plasminogen	Mus musculus	0-11
9038815-1	1997	Molecular cloning and expression have previously defined three members of the Na+/H+ exchanger (NHE) gene family NHE1 and NHE2 are sensitive to inhibition by amiloride and its 5"-amino alkyl-substituted analogues, whereas NHE3 is quite resistant to amiloride inhibition.	Amiloride	158-167	solute carrier family 9 member A1	Rattus norvegicus	113-117
9038815-1	1997	Molecular cloning and expression have previously defined three members of the Na+/H+ exchanger (NHE) gene family NHE1 and NHE2 are sensitive to inhibition by amiloride and its 5"-amino alkyl-substituted analogues, whereas NHE3 is quite resistant to amiloride inhibition.	Amiloride	158-167	solute carrier family 9 member A2	Rattus norvegicus	122-126
9038815-1	1997	Molecular cloning and expression have previously defined three members of the Na+/H+ exchanger (NHE) gene family NHE1 and NHE2 are sensitive to inhibition by amiloride and its 5"-amino alkyl-substituted analogues, whereas NHE3 is quite resistant to amiloride inhibition.	Amiloride	158-167	solute carrier family 9 member A3	Rattus norvegicus	222-226
9038815-1	1997	Molecular cloning and expression have previously defined three members of the Na+/H+ exchanger (NHE) gene family NHE1 and NHE2 are sensitive to inhibition by amiloride and its 5"-amino alkyl-substituted analogues, whereas NHE3 is quite resistant to amiloride inhibition.	Amiloride	249-258	solute carrier family 9 member A1	Rattus norvegicus	113-117
9038815-1	1997	Molecular cloning and expression have previously defined three members of the Na+/H+ exchanger (NHE) gene family NHE1 and NHE2 are sensitive to inhibition by amiloride and its 5"-amino alkyl-substituted analogues, whereas NHE3 is quite resistant to amiloride inhibition.	Amiloride	249-258	solute carrier family 9 member A2	Rattus norvegicus	122-126
9038815-1	1997	Molecular cloning and expression have previously defined three members of the Na+/H+ exchanger (NHE) gene family NHE1 and NHE2 are sensitive to inhibition by amiloride and its 5"-amino alkyl-substituted analogues, whereas NHE3 is quite resistant to amiloride inhibition.	Amiloride	249-258	solute carrier family 9 member A3	Rattus norvegicus	222-226
9038815-9	1997	NHE4 is extremely resistant to amiloride and ethylisopropylamiloride inhibition and, unlike other NHE isoforms, affects K+/H+ exchange as well as Na+/H+ and Li+/H+ exchange.	Amiloride	31-40	solute carrier family 9 member A4	Rattus norvegicus	0-4
9479630-7	1997	These results indicate that the cytoprotective effect of EGF appears to involve both the activation of amiloride-resistant Na+/H+ exchangers and the synthesis of a new protein related to Na+/H+ exchangers.	Amiloride	103-112	epidermal growth factor like 1	Rattus norvegicus	57-60
9159652-0	1997	Hyposmolality-induced enhancement of ADH action on amiloride-sensitive Isc in renal epithelial A6 cells.	Amiloride	51-60	arginine vasopressin	Homo sapiens	37-40
9159652-4	1997	ADH stimulated the amiloride-sensitive Isc.	Amiloride	19-28	arginine vasopressin	Homo sapiens	0-3
9159652-6	1997	The stimulatory action of hyposmolality on the amiloride-sensitive Isc was significantly diminished by pretreatment with brefeldin A (BFA, a blocker of protein translocation), while BFA had no significant effect on the ratio of ADH-stimulated amiloride-sensitive Isc to basal amiloride-sensitive Isc.	Amiloride	47-56	arginine vasopressin	Homo sapiens	228-231
9074782-2	1997	mec-4 and mec-10 encode proteins hypothesized to be subunits of a mechanically gated ion channel that are related to subunits of the vertebrate amiloride-sensitive epithelial Na+ channel.	Amiloride	144-153	Degenerin mec-4	Caenorhabditis elegans	0-5
9074782-2	1997	mec-4 and mec-10 encode proteins hypothesized to be subunits of a mechanically gated ion channel that are related to subunits of the vertebrate amiloride-sensitive epithelial Na+ channel.	Amiloride	144-153	Degenerin mec-10	Caenorhabditis elegans	10-16
9288535-11	1997	Peripheral blood cells express NHE-1, which likely accounts for amiloride-sensitive Na-H exchange in these cells, playing a role in cell volume and pH regulation.	Amiloride	64-73	solute carrier family 9 member A1	Rattus norvegicus	31-36
8955109-3	1996	Compared with other isoforms, NHE3 is known to have a unique profile of sensitivity to pharmacologic inhibitors, including relative resistance to amiloride analogs and HOE694.	Amiloride	146-155	solute carrier family 9 member A3	Rattus norvegicus	30-34
8941347-5	1996	in a concentration dependent manner and provide evidence that rANP affects the amiloride sensitive Na+/H- channel.	Amiloride	79-88	natriuretic peptide A	Rattus norvegicus	62-66
8997251-8	1996	Inhibition of Na+/H+ antiporter activity by amiloride diminishes pHi recovery and thereby accumulation of protons at the outer surface of the plasma membrane.	Amiloride	44-53	glucose-6-phosphate isomerase	Rattus norvegicus	65-68
8996639-4	1996	The recovery of pHi and concomitant Na+/H+ fluxes were reversibly inhibited by amiloride.	Amiloride	79-88	glucose-6-phosphate isomerase	Rattus norvegicus	16-19
8996639-11	1996	Thus, the pHi in the skin basal cells was regulated by the amiloride-sensitive exchange system, and this system seems to be involved in the keratin synthesis.	Amiloride	59-68	glucose-6-phosphate isomerase	Rattus norvegicus	10-13
27406671-4	1996	Activation of the antiporter protein by insulin can stimulate glycolysis by an increase in intracellular pH, an effect which is prevented by amiloride.	Amiloride	141-150	insulin	Homo sapiens	40-47
8922722-11	1996	Various amiloride analogues inhibited the angiotensin II-induced stimulation of the Na+/H+ exchanger, the increase in cytosolic Ca2+ and cell growth but not the induction of c-fos mRNA.	Amiloride	8-17	angiotensinogen	Homo sapiens	42-56
8951724-9	1996	Amiloride at 10(-4) M significantly attenuated the action of AII at 10(-11) M (P < 0.0001) and inhibited the transient response to AII at 10(-5) M (P < 0.01).	Amiloride	0-9	angiotensinogen	Rattus norvegicus	61-64
8951724-9	1996	Amiloride at 10(-4) M significantly attenuated the action of AII at 10(-11) M (P < 0.0001) and inhibited the transient response to AII at 10(-5) M (P < 0.01).	Amiloride	0-9	angiotensinogen	Rattus norvegicus	134-137
8922722-4	1996	Since intracellular pH, the intracellular free Ca2+ concentration and the expression of the transcription factor c-fos seem to be involved in the regulation of cell growth, the effects of the amiloride analogues and Hoe 694 on the angiotensin II-induced changes in these three parameters were examined.	Amiloride	192-201	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-118
8922722-4	1996	Since intracellular pH, the intracellular free Ca2+ concentration and the expression of the transcription factor c-fos seem to be involved in the regulation of cell growth, the effects of the amiloride analogues and Hoe 694 on the angiotensin II-induced changes in these three parameters were examined.	Amiloride	192-201	angiotensinogen	Homo sapiens	231-245
8946004-2	1996	The amiloride-sensitive whole cell current (INa) was measured in principal cells of dissected, split-open tubules from rats maintained either on a control diet or on a low-Na diet to increase endogenous aldosterone secretion.	Amiloride	4-13	internexin neuronal intermediate filament protein, alpha	Rattus norvegicus	44-47
8897813-1	1996	The individual effects of aldosterone and insulin on amiloride-sensitive Na+ transport in model renal epithelia have been well characterized.	Amiloride	53-62	insulin	Homo sapiens	42-49
8933368-4	1996	In HCO3(-)-containing solution 2 mM amiloride slowed but did not block pHi recovery; the recovery however was dependent on extracellular [Na+] and sensitive to 0.3 mM DIDS, suggesting the presence of Na+/HCO3 cotransporter and/or Na(+)-dependent Cl-/HCO3-exchanger.	Amiloride	36-45	solute carrier family 4 (anion exchanger), member 4	Mus musculus	200-222
8913361-1	1996	Allosteric regulation of rat D2 dopamine receptors by amiloride and amiloride analogs has been studied by investigating their ability to accelerate the dissociation of [3H]spiperone from the receptors expressed in Ltk- cells.	Amiloride	68-77	leukocyte receptor tyrosine kinase	Rattus norvegicus	214-217
8938899-7	1996	RESULTS: In both villus and crypt cells incubated in Hepes buffer, removal of Na+ or addition of amiloride decreased basal pHi and pHi recovery after intracellular acidification, indicating an Na+/H+ exchanger in both cell types.	Amiloride	97-106	glucose-6-phosphate isomerase	Homo sapiens	123-126
8938899-7	1996	RESULTS: In both villus and crypt cells incubated in Hepes buffer, removal of Na+ or addition of amiloride decreased basal pHi and pHi recovery after intracellular acidification, indicating an Na+/H+ exchanger in both cell types.	Amiloride	97-106	glucose-6-phosphate isomerase	Homo sapiens	131-134
8898647-11	1996	Under control and ATP-stimulated conditions, 1 mmol/L amiloride blocked pH1 recovery, indicating true activation of Na+, H+ antiporter by extracellular ATP.	Amiloride	54-63	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	72-75
8839852-3	1996	However, we unexpectedly found that high concentrations of amiloride dose-dependently inhibited 125I-fibrinogen binding to the chymotrypsin-treated platelets, as well as the platelet aggregation (IC50 [50% inhibitory concentration] for fibrinogen binding, 530 mumol/L).	Amiloride	59-68	fibrinogen beta chain	Homo sapiens	101-111
8839852-3	1996	However, we unexpectedly found that high concentrations of amiloride dose-dependently inhibited 125I-fibrinogen binding to the chymotrypsin-treated platelets, as well as the platelet aggregation (IC50 [50% inhibitory concentration] for fibrinogen binding, 530 mumol/L).	Amiloride	59-68	fibrinogen beta chain	Homo sapiens	236-246
8841424-12	1996	SV40-T2 expressed the cloned alpha- and gamma-mRNAs for the rat epithelial Na+ channel (rENaC), whereas beta subunit was not detected, and 22Na+ influx was significantly inhibited by 10 microM amiloride.	Amiloride	193-202	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	88-93
8702706-1	1996	Plasma membrane Na+/H+ exchanger (NHE) isoforms NHE1 and NHE3 exhibit very different sensitivities to amiloride and its 5-amino-substituted analogues, benzoyl guanidinium derivatives (e.g. (3-methylsulfonyl-4-piperidinobenzoyl)guanidine methanesulfonate (HOE694)), and cimetidine.	Amiloride	102-111	sodium/hydrogen exchanger 1	Cricetulus griseus	48-52
8805680-0	1996	Disturbed myeloperoxidase-dependent activity of neutrophils in cystic fibrosis homozygotes and heterozygotes, and its correction by amiloride.	Amiloride	132-141	myeloperoxidase	Homo sapiens	10-25
8805680-6	1996	Extracellular release of MPO, measured by an ELISA to provide an activity-independent assessment of the enzyme, was increased only in CF homozygotes, and was decreased by amiloride and choline buffer, but not by EIPA.	Amiloride	171-180	myeloperoxidase	Homo sapiens	25-28
8770057-8	1996	Both amiloride and ribavirin inhibited IL-8 mRNA induction.	Amiloride	5-14	C-X-C motif chemokine ligand 8	Homo sapiens	39-43
8770057-12	1996	Amiloride also inhibited IL-8 release from A549 cells stimulated with IL-1 or tumor necrosis factor.	Amiloride	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	25-29
8770057-12	1996	Amiloride also inhibited IL-8 release from A549 cells stimulated with IL-1 or tumor necrosis factor.	Amiloride	0-9	interleukin 1 alpha	Homo sapiens	70-74
8770057-13	1996	Amiloride similarly inhibited IL-8 protein release from primary human airway epithelium infected with RSV.	Amiloride	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	30-34
8770062-6	1996	The TGF-alpha-stimulated increase in alveolar liquid clearance was inhibited by amiloride (10(-4) M), indicating that the increase in clearance depended on increased Na+ uptake across the alveolar epithelium.	Amiloride	80-89	transforming growth factor alpha	Rattus norvegicus	4-13
8840262-11	1996	Amiloride decreased in a dose-dependent manner Isc from untreated and AVP-treated RCCD1 cells.	Amiloride	0-9	RCC1 domain containing 1	Rattus norvegicus	82-87
8764970-4	1996	We have found that this epithelium responds to aldosterone, antidiuretic hormone (ADH) and insulin like growth factor 1 (IGF1) with increases in amiloride-sensitive Na+ transport.	Amiloride	145-154	insulin like growth factor 1	Canis lupus familiaris	91-119
8764970-4	1996	We have found that this epithelium responds to aldosterone, antidiuretic hormone (ADH) and insulin like growth factor 1 (IGF1) with increases in amiloride-sensitive Na+ transport.	Amiloride	145-154	insulin like growth factor 1	Canis lupus familiaris	121-125
8663566-13	1996	Apx-transfection was associated with a 60-900% increase in amiloride-sensitive (Ki = 3 microM) Na+ currents.	Amiloride	59-68	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	0-3
8760127-8	1996	The open probability of these channels was increased by the addition of protein kinase A (PKA) and ATP, and was decreased to the same extent by addition of [N-ethyl-N-isopropyl]-2"-4"-amiloride (EIPA) and amiloride (1 microM each) in the apical side of the bilayer, in agreement with the results of patch-clamp studies in ATII cells.	Amiloride	184-193	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	72-88
8760127-8	1996	The open probability of these channels was increased by the addition of protein kinase A (PKA) and ATP, and was decreased to the same extent by addition of [N-ethyl-N-isopropyl]-2"-4"-amiloride (EIPA) and amiloride (1 microM each) in the apical side of the bilayer, in agreement with the results of patch-clamp studies in ATII cells.	Amiloride	184-193	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	90-93
8759925-7	1996	In addition to serving as a Cl channel, there is compelling evidence that CFTR inhibits the amiloride-sensitive, epithelial sodium channel (ENaC).	Amiloride	92-101	CF transmembrane conductance regulator	Homo sapiens	74-78
8760146-4	1996	Pretreating with amiloride inverted the response to protamine, resulting in an increase in Isc, depolarization of the apical membrane, and decrease in the fractional resistance of the apical membrane (fRa).	Amiloride	17-26	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	201-204
8760255-9	1996	The effects of ANG II on fluid and ion transport were abolished by the luminal application of amiloride (10(-3) M) and of the angiotensin-receptor blocker [Sar1,Ile8]ANG II (10(-6) M).	Amiloride	94-103	angiotensinogen	Rattus norvegicus	15-21
8679650-5	1996	Both 1 mM amiloride and Na(+)-free solution inhibited pHi recovery from acidification and decreased pHi in resting cells.	Amiloride	10-19	glucose-6-phosphate isomerase	Homo sapiens	54-57
8677271-6	1996	Under basal conditions, amiloride (100 microMol) and H2DIDS (0.5 mM) decreased pHi 0.12 +/- 0.01 and 0.05 +/- 0.01 pH units, respectively.	Amiloride	24-33	glucose-6-phosphate isomerase	Homo sapiens	79-82
8677271-12	1996	pHi recovery during elevated PCO2 was blocked by amiloride, H2DIDS, or Na+-free media.	Amiloride	49-58	glucose-6-phosphate isomerase	Homo sapiens	0-3
8679650-5	1996	Both 1 mM amiloride and Na(+)-free solution inhibited pHi recovery from acidification and decreased pHi in resting cells.	Amiloride	10-19	glucose-6-phosphate isomerase	Homo sapiens	100-103
8679650-8	1996	In the presence of amiloride and 200 microM H2DIDS pHi recovery was completely inhibited.	Amiloride	19-28	glucose-6-phosphate isomerase	Homo sapiens	51-54
8725658-4	1996	Using BAPTA (a chelating agent of Ca2+) and amiloride (an inhibitor of the Na+/H+ exchanger), we found that the elevation of pHi requires the elevation of [Ca2+]i but that the elevation of [Ca2+]i does not always require a rise in pHi.	Amiloride	44-53	glucose-6-phosphate isomerase	Homo sapiens	125-128
8725658-4	1996	Using BAPTA (a chelating agent of Ca2+) and amiloride (an inhibitor of the Na+/H+ exchanger), we found that the elevation of pHi requires the elevation of [Ca2+]i but that the elevation of [Ca2+]i does not always require a rise in pHi.	Amiloride	44-53	glucose-6-phosphate isomerase	Homo sapiens	231-234
9240763-4	1996	The insulin-induced pHi increase was almost completely inhibited by 10(-3) mol/l amiloride in the lumen, indicating that insulin activates luminal Na/H exchange in PST.	Amiloride	81-90	insulin	Oryctolagus cuniculus	4-11
9240763-4	1996	The insulin-induced pHi increase was almost completely inhibited by 10(-3) mol/l amiloride in the lumen, indicating that insulin activates luminal Na/H exchange in PST.	Amiloride	81-90	insulin	Oryctolagus cuniculus	121-128
8640238-4	1996	These two chromosomal regions harbour the genes encoding the three subunits of the human amiloride sensitive epithelial sodium channel (hENaC): SCNN1B and SCNN1G on 16p and SCNN1A on 12p.	Amiloride	89-98	sodium channel epithelial 1 subunit beta	Homo sapiens	144-150
8640238-4	1996	These two chromosomal regions harbour the genes encoding the three subunits of the human amiloride sensitive epithelial sodium channel (hENaC): SCNN1B and SCNN1G on 16p and SCNN1A on 12p.	Amiloride	89-98	sodium channel epithelial 1 subunit gamma	Homo sapiens	155-161
8640238-4	1996	These two chromosomal regions harbour the genes encoding the three subunits of the human amiloride sensitive epithelial sodium channel (hENaC): SCNN1B and SCNN1G on 16p and SCNN1A on 12p.	Amiloride	89-98	sodium channel epithelial 1 subunit alpha	Homo sapiens	173-179
8665845-1	1996	Liddle syndrome is an autosomal dominant form of hypertension, resulting from mutations in the cytoplasmic C-terminus of either the beta or gamma subunits of the amiloride-sensitive epithelial Na channel (ENaC) which lead to constitutively increased channel activity.	Amiloride	162-171	sodium voltage-gated channel alpha subunit 8	Rattus norvegicus	193-203
8665845-1	1996	Liddle syndrome is an autosomal dominant form of hypertension, resulting from mutations in the cytoplasmic C-terminus of either the beta or gamma subunits of the amiloride-sensitive epithelial Na channel (ENaC) which lead to constitutively increased channel activity.	Amiloride	162-171	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	205-209
8967432-6	1996	Such findings suggest that CFTR may also regulate amiloride-insensitive Na+ channels.	Amiloride	50-59	CF transmembrane conductance regulator	Homo sapiens	27-31
8762078-16	1996	Relaxation to VIP was impaired significantly following exposure of tissues to a low Na+ solution (30 min) or amiloride (500 microM; 30 min).	Amiloride	109-118	VIP peptides	Cavia porcellus	14-17
8772124-10	1996	Expression of the rENaC alpha-subunit-deletion mutant, Delta278-283, which lacks a putative amiloride-binding site, induced a Na+ channel with a greatly reduced affinity for both triamterene and amiloride.	Amiloride	92-101	sodium channel epithelial 1 subunit alpha	Rattus norvegicus	18-29
8772124-10	1996	Expression of the rENaC alpha-subunit-deletion mutant, Delta278-283, which lacks a putative amiloride-binding site, induced a Na+ channel with a greatly reduced affinity for both triamterene and amiloride.	Amiloride	195-204	sodium channel epithelial 1 subunit alpha	Rattus norvegicus	18-29
8772124-12	1996	We propose that amiloride and triamterene bind to rENaC using very similar mechanisms.	Amiloride	16-25	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	50-55
8772128-7	1996	Resistance to amiloride and EIPA, and inhibition by PMA are consistent with the involvement of the NHE3 isoform.	Amiloride	14-23	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	99-103
8774073-5	1996	Plasma and cardiac angiotensin II (AII) levels were decreased in amiloride-treated groups compared with those in furosemide or control group (p < 0.05).	Amiloride	65-74	arginase type II	Mus musculus	19-33
8789815-10	1996	The alkalinization of pHi in the presence of propionate was inhibited by the NHE blockers amiloride and EIPA.	Amiloride	90-99	glucose-6-phosphate isomerase	Homo sapiens	22-25
8789815-10	1996	The alkalinization of pHi in the presence of propionate was inhibited by the NHE blockers amiloride and EIPA.	Amiloride	90-99	solute carrier family 9 member C1	Homo sapiens	77-80
8789815-12	1996	The NHE blocker amiloride caused in vestibular dark cells an acidification of pHi and a decrease in CH.	Amiloride	16-25	solute carrier family 9 member C1	Homo sapiens	4-7
8789815-12	1996	The NHE blocker amiloride caused in vestibular dark cells an acidification of pHi and a decrease in CH.	Amiloride	16-25	glucose-6-phosphate isomerase	Homo sapiens	78-81
8789815-14	1996	Similar effects and pHi were observed in vestibular dark cells with the amiloride analog ethyl-isopropyl-amiloride (EIPA) and similar effects on Isc were observed with EIPA and the NHE blocker HOE694 when applied to the basolateral side of vestibular dark cell epithelium.	Amiloride	72-81	glucose-6-phosphate isomerase	Homo sapiens	20-23
8722625-8	1996	PA activity in the medium was due primarily to uPA because 1) PA activity was inhibited by a uPA-specific inhibitor-amiloride-and by an anti-mouse uPA antibody, and 2) the predominant PA activity in the medium, as identified in zymography, had a molecular mass of approximately 40 kDa, similar to that reported for uPA.	Amiloride	116-125	plasminogen activator, urokinase	Rattus norvegicus	47-50
8722625-8	1996	PA activity in the medium was due primarily to uPA because 1) PA activity was inhibited by a uPA-specific inhibitor-amiloride-and by an anti-mouse uPA antibody, and 2) the predominant PA activity in the medium, as identified in zymography, had a molecular mass of approximately 40 kDa, similar to that reported for uPA.	Amiloride	116-125	plasminogen activator, urokinase	Rattus norvegicus	93-96
8722625-8	1996	PA activity in the medium was due primarily to uPA because 1) PA activity was inhibited by a uPA-specific inhibitor-amiloride-and by an anti-mouse uPA antibody, and 2) the predominant PA activity in the medium, as identified in zymography, had a molecular mass of approximately 40 kDa, similar to that reported for uPA.	Amiloride	116-125	plasminogen activator, urokinase	Rattus norvegicus	93-96
8722625-8	1996	PA activity in the medium was due primarily to uPA because 1) PA activity was inhibited by a uPA-specific inhibitor-amiloride-and by an anti-mouse uPA antibody, and 2) the predominant PA activity in the medium, as identified in zymography, had a molecular mass of approximately 40 kDa, similar to that reported for uPA.	Amiloride	116-125	plasminogen activator, urokinase	Rattus norvegicus	93-96
8980031-3	1996	The Na+/Ca2+ exchanger blocker amiloride caused a significant inhibition of delta-hexachlorocyclohexane effects.	Amiloride	31-40	nascent polypeptide associated complex subunit alpha 2	Homo sapiens	4-11
8774073-5	1996	Plasma and cardiac angiotensin II (AII) levels were decreased in amiloride-treated groups compared with those in furosemide or control group (p < 0.05).	Amiloride	65-74	arginase type II	Mus musculus	35-38
8774073-6	1996	Our findings suggest that amiloride prevents the development of myocardial hypertrophy and left ventricular dilatation in DCM in association with a reduction of AII.	Amiloride	26-35	arginase type II	Mus musculus	161-164
8627323-6	1996	uPA activity was confirmed by incubating the extracts with amiloride, an inhibitor of uPA.	Amiloride	59-68	plasminogen activator, urokinase	Homo sapiens	0-3
9102830-5	1996	Amilorid, previously known as a diuretic, is found to be a competitive inhibitor of plasminogen activator-urokinase (u-PA).	Amiloride	0-8	urokinase-type plasminogen activator	Oryctolagus cuniculus	117-121
8723228-5	1996	In the absence of HCO3-, amiloride blocked pHi recovery after an acid load with an IC50 of approximately 3.18 microM, similar to values reported for the amiloride-sensitive isoforms NHE1 and NHE2.	Amiloride	25-34	glucose-6-phosphate isomerase	Rattus norvegicus	43-46
8723228-8	1996	Surprisingly, application of the potent analog of amiloride, ethylisopropylamiloride (EIPA), caused a reversible alkalinization of pHi, suggesting the presence of an additional acid/base transport mechanism that is EIPA-sensitive.	Amiloride	50-59	glucose-6-phosphate isomerase	Rattus norvegicus	131-134
8967348-3	1996	Addition of 1 mM amiloride or 50 microM ethylisopropylamiloride (EIPA) to the lumen decreased HCO3- absorption (JHCO3) from 10.6 +/- 0.5 to 2.3 +/- 0.3 pmol.min-1.mm-1 (P < 0.001) and pHi from 7.10 +/- 0.02 to 6.86 +/- 0.03 (P < 0.001).	Amiloride	17-26	glucose-6-phosphate isomerase	Rattus norvegicus	187-190
8967348-7	1996	With 4 mM NH4Cl in perfusate and bath, luminal addition of amiloride decreased pHi from 6.70 +/- 0.06 to 6.50 +/- 0.05 (P < 0.005) but had no effect on net ammonium absorption.	Amiloride	59-68	glucose-6-phosphate isomerase	Rattus norvegicus	79-82
8735075-3	1996	The transduction channels are known to be amiloride-sensitive and immunogold labelling with antibodies raised against the amiloride-sensitive epithelial Na+ channel from kidney (alpha NaCh), has suggested that sites with similar characteristics are located in the region where the tips of the shorter stereocilia appear to come into contact with the sides of the adjacent taller stereocilia rather than being associated directly with the tip links.	Amiloride	42-51	sodium channel epithelial 1 subunit alpha	Homo sapiens	178-188
8735075-3	1996	The transduction channels are known to be amiloride-sensitive and immunogold labelling with antibodies raised against the amiloride-sensitive epithelial Na+ channel from kidney (alpha NaCh), has suggested that sites with similar characteristics are located in the region where the tips of the shorter stereocilia appear to come into contact with the sides of the adjacent taller stereocilia rather than being associated directly with the tip links.	Amiloride	122-131	sodium channel epithelial 1 subunit alpha	Homo sapiens	178-188
8735075-7	1996	Because amiloride is known to protect amiloride-binding sites from degradation by trypsin, these results suggest that alpha NaCh is revealing amiloride-binding sites on the stereocilia.	Amiloride	8-17	sodium channel epithelial 1 subunit alpha	Homo sapiens	118-128
8735075-7	1996	Because amiloride is known to protect amiloride-binding sites from degradation by trypsin, these results suggest that alpha NaCh is revealing amiloride-binding sites on the stereocilia.	Amiloride	38-47	sodium channel epithelial 1 subunit alpha	Homo sapiens	118-128
8735075-7	1996	Because amiloride is known to protect amiloride-binding sites from degradation by trypsin, these results suggest that alpha NaCh is revealing amiloride-binding sites on the stereocilia.	Amiloride	38-47	sodium channel epithelial 1 subunit alpha	Homo sapiens	118-128
9102830-5	1996	Amilorid, previously known as a diuretic, is found to be a competitive inhibitor of plasminogen activator-urokinase (u-PA).	Amiloride	0-8	urokinase-type plasminogen activator	Oryctolagus cuniculus	84-115
8674384-2	1996	NHE1 and NHE2 are much more sensitive to inhibition by amiloride than NHE3, their in vitro IC50s for amiloride being 1 microM, 1 microM and 39 microM, respectively.	Amiloride	55-64	solute carrier family 9 member A1	Canis lupus familiaris	0-4
8674384-2	1996	NHE1 and NHE2 are much more sensitive to inhibition by amiloride than NHE3, their in vitro IC50s for amiloride being 1 microM, 1 microM and 39 microM, respectively.	Amiloride	55-64	solute carrier family 9 member A2	Homo sapiens	9-13
8674384-2	1996	NHE1 and NHE2 are much more sensitive to inhibition by amiloride than NHE3, their in vitro IC50s for amiloride being 1 microM, 1 microM and 39 microM, respectively.	Amiloride	101-110	solute carrier family 9 member A1	Canis lupus familiaris	0-4
8674384-2	1996	NHE1 and NHE2 are much more sensitive to inhibition by amiloride than NHE3, their in vitro IC50s for amiloride being 1 microM, 1 microM and 39 microM, respectively.	Amiloride	101-110	solute carrier family 9 member A2	Homo sapiens	9-13
8674384-2	1996	NHE1 and NHE2 are much more sensitive to inhibition by amiloride than NHE3, their in vitro IC50s for amiloride being 1 microM, 1 microM and 39 microM, respectively.	Amiloride	101-110	solute carrier family 9 member A3	Homo sapiens	70-74
8674384-7	1996	Luminal amiloride was administered from the second to the fourth hours at doses of 20 microM in groups 3 and 4 to inhibit NHE1 and NHE2, and 1mM in groups 5 and 6 to also inhibit NHE3.	Amiloride	8-17	solute carrier family 9 member A1	Canis lupus familiaris	122-126
8674384-7	1996	Luminal amiloride was administered from the second to the fourth hours at doses of 20 microM in groups 3 and 4 to inhibit NHE1 and NHE2, and 1mM in groups 5 and 6 to also inhibit NHE3.	Amiloride	8-17	solute carrier family 9 member A2	Homo sapiens	131-135
8674384-7	1996	Luminal amiloride was administered from the second to the fourth hours at doses of 20 microM in groups 3 and 4 to inhibit NHE1 and NHE2, and 1mM in groups 5 and 6 to also inhibit NHE3.	Amiloride	8-17	solute carrier family 9 member A3	Homo sapiens	179-183
8627323-6	1996	uPA activity was confirmed by incubating the extracts with amiloride, an inhibitor of uPA.	Amiloride	59-68	plasminogen activator, urokinase	Homo sapiens	86-89
8778469-4	1996	Because amiloride-inhibitable 22Na+ uptake reflects Na(+)-channel function, these data indicate that terbutaline may transiently upregulate Na(+)-channel function.	Amiloride	8-17	sodium voltage-gated channel alpha subunit 8	Rattus norvegicus	140-153
8638665-3	1996	The effect of EGF was inhibited by amiloride analogue 5-(N-ethyl-N-isopropyl) amiloride (EIPA), by ouabain, inhibitor of the Na+ pump, and by erbstatin analogue, an inhibitor of the tyrosine kinase activity of the EGF receptor.	Amiloride	35-44	epidermal growth factor	Rattus norvegicus	14-17
8601583-10	1996	Cross-linking of surface bound antibodies (mAb) directed against FcgammaRs (FcgammaRII > FcgammaRIII) but not beta2 integrins induced an amiloride-sensitive cytosolic alkalinization.	Amiloride	140-149	Fc gamma receptor IIIa	Homo sapiens	92-103
8641437-4	1996	The expression of all three (alpha, beta, gamma) subunits of the rat epithelial Na+ channel (rENaC) and wild type (wt) CFTR resulted in the expected amiloride sensitive Na+ and IBMX (1 mmol/l) activated Cl- currents, respectively.	Amiloride	149-158	CF transmembrane conductance regulator	Rattus norvegicus	119-123
8641437-5	1996	The amiloride sensitive Na+ conductance was, however, inhibited when the wt-CFTR Cl- conductance was activated by phosphodiesterase inhibition (IBMX).	Amiloride	4-13	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	Xenopus laevis	76-80
7493949-4	1995	Incubation of cells with either AIF4-, a general agonist of G proteins, or cholera toxin, a selective activator of G alpha s that stimulates adenylate cyclase, accelerated the rates of amiloride-inhibitable 22Na+ influx mediated by NHE-1 and -2, whereas they inhibited that by NHE-3.	Amiloride	185-194	solute carrier family 9 member A1	Rattus norvegicus	232-244
8886182-4	1996	PTH caused an initial activation of Na(+)-H+ exchanger, and this stimulation is amiloride sensitive.	Amiloride	80-89	parathyroid hormone	Homo sapiens	0-3
8554515-5	1995	Recovery of pHi in L1210 cells after a nigericin- or NH4(+)-mediated acid load in HCO3(-)-free buffers was mediated by Na+/H+ antiporter activity, in addition to a minor Na(+)-independent and amiloride-insensitive pathway.	Amiloride	192-201	glucose-6-phosphate isomerase 1	Mus musculus	12-15
8589728-4	1996	The adult lung expresses alpha, beta and gamma ENaC (3,4), and an amiloride-sensitive electrogenic sodium reabsorption has been documented in upper and lower airways (3-7), but it is not established whether this sodium transport is mediated by ENaC in vivo.	Amiloride	66-75	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	244-248
8589728-6	1996	Amiloride-sensitive electrogenic Na+ transport was abolished in airway epithelia from alpha-ENaC(-/-) mice.	Amiloride	0-9	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	86-96
8788411-3	1995	5-(N,N-hexamethylene) amiloride (HMA), another amiloride analog which specifically inhibits the Na(+)-H+ antiporter and has no inhibitory activity on the Na(+)-Ca2+ exchanger, at the concentrations of 0.1, 1 and 10 microM, did not affect basal prolactin release whereas it significantly reduced prolactin release stimulated by thyrotropin releasing hormone (TRH) (1 microM).	Amiloride	22-31	thyrotropin releasing hormone	Homo sapiens	358-361
7493949-4	1995	Incubation of cells with either AIF4-, a general agonist of G proteins, or cholera toxin, a selective activator of G alpha s that stimulates adenylate cyclase, accelerated the rates of amiloride-inhibitable 22Na+ influx mediated by NHE-1 and -2, whereas they inhibited that by NHE-3.	Amiloride	185-194	solute carrier family 9 member A3	Rattus norvegicus	277-282
8526925-4	1995	The NaF-induced 22Na+ uptake was sensitive to tetrodotoxin (TTX), pertussis toxin but not to amiloride nor valinomycin.	Amiloride	93-102	C-X-C motif chemokine ligand 8	Homo sapiens	4-7
7484889-10	1995	ACE inhibitors such as perindopril decrease the afterload on the heart more than diuretics such as amiloride/hydrochlorothiazide by both a more pronounced decrease in systemic vascular resistance and an increase in large artery compliance.	Amiloride	99-108	angiotensin I converting enzyme	Homo sapiens	0-3
7588286-5	1995	Amiloride, a specific blocker of the Na(+)-H+ exchanger, reduced pHi, as described above, and inhibited T3 and T4 uptake by about 35%.	Amiloride	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	65-68
7491973-3	1995	2) Amiloride-insensitive baseline short-circuit current (Isc) and mediator-induced increases in Isc were inhibited by diphenylamine-2-carboxylic acid (DPAC) but not by 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS), a pharmacology consistent with passage of apical membrane Cl current through CFTR; Ca-activated Cl channels are inhibited by DIDS but not by DPAC.	Amiloride	3-12	CF transmembrane conductance regulator	Homo sapiens	302-306
8606362-17	1995	We conclude that the channel in M-1 cells is closely related to the amiloride-sensitive epithelial Na+ channel in the rat colon and that the M-1 cell line provides a useful tool to investigate the biophysical and molecular properties of the corresponding channel in the cortical collecting duct.	Amiloride	68-77	cholinergic receptor, muscarinic 1, CNS	Mus musculus	32-35
8606362-17	1995	We conclude that the channel in M-1 cells is closely related to the amiloride-sensitive epithelial Na+ channel in the rat colon and that the M-1 cell line provides a useful tool to investigate the biophysical and molecular properties of the corresponding channel in the cortical collecting duct.	Amiloride	68-77	cholinergic receptor, muscarinic 1, CNS	Mus musculus	141-144
8606362-1	1995	Confluent M-1 cells show electrogenic Na+ absorption and possess an amiloride-sensitive Na(+)-conductance (Korbmacher et al., J. Gen. Physiol.	Amiloride	68-77	cholinergic receptor, muscarinic 1, CNS	Mus musculus	10-13
7478437-4	1995	The acidification was readily reversible by cooling the cells back down to 37 degrees C. The pHi change was inhibited by the addition of 1 mM amiloride in the incubation medium.	Amiloride	142-151	glucose-6-phosphate isomerase	Homo sapiens	93-96
8606362-5	1995	Patch clamp experiments were performed in 6-13-day-old confluent M-1 cells at 37 degrees C. In whole-cell experiments application of 10(-5) M amiloride caused a hyperpolarization of 24.9, SEM +/- 2.2 mV (n = 35) and a reduction of the inward current by 107 +/- 10 pA (n = 51) at a holding potential of -60 mV.	Amiloride	142-151	cholinergic receptor, muscarinic 1, CNS	Mus musculus	65-68
8606362-14	1995	Using the two-microelectrode voltage-clamp technique, we assayed defolliculated stage V-VI Xenopus oocytes for an amiloride-sensitive inward current 1-6 days after injection with H2O or with 20-50 ng of M-1 poly(A)+ RNA.	Amiloride	114-123	cholinergic receptor, muscarinic 1, CNS	Mus musculus	203-206
7503797-6	1995	The proton release induced by either ferricyanide or diferric transferrin was inhibited by about 35% at a near optimal amiloride concentration of 0.2 mM or at a dimethylamiloride concentration of 0.075 mM.	Amiloride	119-128	transferrin	Homo sapiens	62-73
8569105-6	1995	Computer models of sites within transmembrane domains of NHE1 and NHE2 isoforms of the Na+/H+ exchanger reflective of these planar tracts indicate that amiloride probably spans two helices for interaction with the Na+/H+ exchanger.	Amiloride	152-161	solute carrier family 9 member A1	Homo sapiens	57-61
8529321-2	1995	The intestinal uptake of oleic acid is influenced by the activity of an amiloride-inhibitable brush border membrane Na+/H+ exchanger, NHE3: opposing Na+/H+ gradients (inward Na+ and outward H+ gradients) increased oleic acid uptake by about 40%, as compared with only an inward Na+ gradient, only an outward H+ gradient, or the absence of either Na+ or H+ gradients.	Amiloride	72-81	solute carrier family 9 member A3	Rattus norvegicus	134-138
8569105-6	1995	Computer models of sites within transmembrane domains of NHE1 and NHE2 isoforms of the Na+/H+ exchanger reflective of these planar tracts indicate that amiloride probably spans two helices for interaction with the Na+/H+ exchanger.	Amiloride	152-161	solute carrier family 9 member A2	Homo sapiens	66-70
7544595-4	1995	Basal PDs were not different (CFTR (+/-), 8.6 mV, and CFTR (-/-), 9.1 mV), and PDs of both groups were inhibited by intraluminal injection of amiloride (10(-4) M) (-25%) and after addition of bumetanide (10(-4) M) to the bath (-40%).	Amiloride	142-151	cystic fibrosis transmembrane conductance regulator	Mus musculus	54-58
7653521-2	1995	NHE1 was protected by cimetidine and amiloride from DEPC, and DEPC inhibition was reversed with hydroxylamine, suggesting a role for critical histidine groups in NHE activity.	Amiloride	37-46	solute carrier family 9 member A1	Homo sapiens	0-4
7473248-8	1995	Increasing perfusate osmolarity by addition of 60 mM sucrose caused a 19 +/- 2% decrease in cell volume and a sustained increase in pHi (0.12 +/- 0.01 pH units) that was abolished by 1 mM amiloride.	Amiloride	188-197	glucose-6-phosphate isomerase	Rattus norvegicus	132-135
7473248-13	1995	Steady-state Na(+)-H+ exchanger activity, estimated from the initial rate of change in pHi following addition of amiloride, increased 9-fold during stimulation with ACh.	Amiloride	113-122	glucose-6-phosphate isomerase	Rattus norvegicus	87-90
8638256-12	1995	However, treatment with acetazolamide plus amiloride for 15 hr produced a marked reduction of pHi values throughout the forelimb bud.	Amiloride	43-52	glucose-6-phosphate isomerase 1	Mus musculus	94-97
7653521-2	1995	NHE1 was protected by cimetidine and amiloride from DEPC, and DEPC inhibition was reversed with hydroxylamine, suggesting a role for critical histidine groups in NHE activity.	Amiloride	37-46	solute carrier family 9 member C1	Homo sapiens	0-3
7653521-5	1995	The 50% inhibition concentration values for amiloride, ethyl isopropyl amiloride (EIPA), and cimetidine of the H349G mutant were significantly increased compared with the wild-type NHE1.	Amiloride	44-53	solute carrier family 9 member A1	Homo sapiens	181-185
7653521-6	1995	We also examined the DEPC effect on the transport activity of the triple histidine mutant (H35,120,349G) and found that NHE1 activity was still inhibited by DEPC with reversal by hydroxylamine and protected by amiloride and cimetidine.	Amiloride	210-219	solute carrier family 9 member A1	Homo sapiens	120-124
7653521-11	1995	The H349S (mimics NHE3) and H349Y (mimics NHE4) mutations had only modest effects on amiloride sensitivity.	Amiloride	85-94	solute carrier family 9 member A3	Homo sapiens	18-22
7653521-11	1995	The H349S (mimics NHE3) and H349Y (mimics NHE4) mutations had only modest effects on amiloride sensitivity.	Amiloride	85-94	solute carrier family 9 member A4	Homo sapiens	42-46
7635429-4	1995	Amiloride (1 mmol/L) and external Na+ removal decreased baseline pHi in both HEPES and KRB.	Amiloride	0-9	glucose-6-phosphate isomerase	Homo sapiens	65-68
8530253-9	1995	Finally, EL-4 tumor-cell-induced immunosuppression could not be corrected by any single anti-suppressor agent tested, but a combination of IL-4, GSH and amiloride fully restored the CD3-AK response.	Amiloride	153-162	CD3 antigen, epsilon polypeptide	Mus musculus	182-185
7635429-11	1995	Administration of TGF alpha stimulates DNA synthesis, an effect that is blocked by amiloride, an inhibitor of Na+/H+ exchanger.	Amiloride	83-92	transforming growth factor alpha	Homo sapiens	18-27
7635429-8	1995	Administration of EGF and TGF alpha, but not of IGF-II, induced a dose-dependent, amiloride-inhibitable increase in baseline pHi, together with an increase in Na+/H+ exchange activity, shifting to the right the JH/pHi curve.	Amiloride	82-91	transforming growth factor alpha	Homo sapiens	26-35
7635429-8	1995	Administration of EGF and TGF alpha, but not of IGF-II, induced a dose-dependent, amiloride-inhibitable increase in baseline pHi, together with an increase in Na+/H+ exchange activity, shifting to the right the JH/pHi curve.	Amiloride	82-91	glucose-6-phosphate isomerase	Homo sapiens	125-128
7635429-8	1995	Administration of EGF and TGF alpha, but not of IGF-II, induced a dose-dependent, amiloride-inhibitable increase in baseline pHi, together with an increase in Na+/H+ exchange activity, shifting to the right the JH/pHi curve.	Amiloride	82-91	glucose-6-phosphate isomerase	Homo sapiens	214-217
7635429-9	1995	Finally, 3H-thymidine incorporation in Hep G2 cells, in the presence of FCS or TGF alpha, was strongly inhibited by amiloride.	Amiloride	116-125	transforming growth factor alpha	Homo sapiens	79-88
7543055-0	1995	Amiloride suppresses erythropoietin-induced proliferation and MAP kinase, but potentiates differentiation of J2E cells.	Amiloride	0-9	erythropoietin	Mus musculus	21-35
7631745-5	1995	The reconstituted channel had all the characteristics of the native type 1 ENaC described in A6 cells: 1) high selectivity, 2) low single-channel conductance, 3) slow gating kinetics, and 4) high affinity for amiloride.	Amiloride	209-218	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	75-79
7631746-6	1995	Functionally, human NHE3 was similar to the rabbit and rat NHE3 homologues, being relatively resistant to inhibition by amiloride, half-maximal inhibition (IC50) = 49.0 microM, and ethylisopropylamiloride, IC50 = 6.6 microM, and being stimulated by fibroblast growth factor but inhibited by phorbol 12-myristate 13-acetate.	Amiloride	120-129	solute carrier family 9 member A3	Homo sapiens	20-24
8585035-0	1995	Amiloride inhibits tissue-type plasminogen activator (t-PA) release from vascular endothelium.	Amiloride	0-9	plasminogen activator, tissue type	Homo sapiens	19-52
8585035-0	1995	Amiloride inhibits tissue-type plasminogen activator (t-PA) release from vascular endothelium.	Amiloride	0-9	plasminogen activator, tissue type	Homo sapiens	54-58
7612649-0	1995	Substrate dependence of amiloride- and soman-induced conformation changes of butyrylcholinesterase as evidenced by high-pressure perturbation.	Amiloride	24-33	butyrylcholinesterase	Homo sapiens	77-98
7612649-3	1995	First, we examined the effect of amiloride, a reversible cholinesterase effector, upon the butyrylcholinesterase-catalyzed hydrolysis of nitrophenyl esters.	Amiloride	33-42	butyrylcholinesterase	Homo sapiens	57-71
7612649-3	1995	First, we examined the effect of amiloride, a reversible cholinesterase effector, upon the butyrylcholinesterase-catalyzed hydrolysis of nitrophenyl esters.	Amiloride	33-42	butyrylcholinesterase	Homo sapiens	91-112
7612649-6	1995	Results show that the effect of reversible soman binding on butyrylcholinesterase activity in the presence of amiloride depends on the position of the substrate nitro group and amiloride concentration.	Amiloride	110-119	butyrylcholinesterase	Homo sapiens	60-81
7612649-6	1995	Results show that the effect of reversible soman binding on butyrylcholinesterase activity in the presence of amiloride depends on the position of the substrate nitro group and amiloride concentration.	Amiloride	177-186	butyrylcholinesterase	Homo sapiens	60-81
7543055-6	1995	Immunoblotting with anti-phosphotyrosine antibodies revealed that amiloride reduced the number of phosphorylated proteins in epo-stimulated cells.	Amiloride	66-75	erythropoietin	Mus musculus	125-128
7543055-7	1995	Moreover, the protein content of p42 and p44 MAP kinases was noticeably downregulated in amiloride-treated cultures.	Amiloride	89-98	cyclin-dependent kinase 20	Mus musculus	33-36
7543055-7	1995	Moreover, the protein content of p42 and p44 MAP kinases was noticeably downregulated in amiloride-treated cultures.	Amiloride	89-98	interferon-induced protein 44	Mus musculus	41-44
7543055-8	1995	These data indicate that amiloride may interfere with epo-induced signaling cascades within J2E cells which result in restricted cell division and promotion of maturation.	Amiloride	25-34	erythropoietin	Mus musculus	54-57
7543425-0	1995	Insulin-activated amiloride-blockable nonselective cation and Na+ channels in the fetal distal lung epithelium.	Amiloride	18-27	insulin	Homo sapiens	0-7
7591712-4	1995	The amiloride analog 5-(N-ethyl-N-isopropyl)amiloride (EIPA), an inhibitor of the Na+/H+ antiporter, inhibited TNF-alpha production with an EC50 of 3.3 microM.	Amiloride	4-13	tumor necrosis factor	Homo sapiens	111-120
7789340-3	1995	pHi recovery induced by 30 mM NaCl was blocked by 100 microM amiloride.	Amiloride	61-70	glucose-6-phosphate isomerase	Rattus norvegicus	0-3
7494140-5	1995	The currents mirrored the changes in pHi, were strictly dependent on the presence of a Na+ gradient and were reversibly blocked by amiloride.	Amiloride	131-140	glucose-6-phosphate isomerase	Homo sapiens	37-40
7796890-6	1995	Inhibition of plasminogen activation occurred with plasminogen activator inhibitor-1, anti-catalytic anti-tissue-plasminogen activator antibody, epsilon-aminocaproic acid, which inhibits the binding of plasminogen through its lysine binding sites, and amiloride, which specifically inhibits urokinase.	Amiloride	252-261	serpin family E member 1	Rattus norvegicus	51-84
7796890-6	1995	Inhibition of plasminogen activation occurred with plasminogen activator inhibitor-1, anti-catalytic anti-tissue-plasminogen activator antibody, epsilon-aminocaproic acid, which inhibits the binding of plasminogen through its lysine binding sites, and amiloride, which specifically inhibits urokinase.	Amiloride	252-261	plasminogen activator, tissue type	Rattus norvegicus	106-134
7728977-5	1995	Administration of amiloride at 7.5 mg/kg significantly decreased the labeling index of the colon mucosa and ornithine decarboxylase activity in the colon wall during and after administration of azoxymethane.	Amiloride	18-27	ornithine decarboxylase 1	Rattus norvegicus	108-131
7603452-10	1995	The [3H]phenamil binding of alpha ENACa resembles that of alpha ENAC, being inhibited more potently by phenamil (Kd = 65 nM) than amiloride.	Amiloride	130-139	sodium channel, non voltage gated 1 alpha subunit L homeolog	Xenopus laevis	34-39
7744735-6	1995	One mM amiloride inhibited both [H+] gradient-stimulated 22Na uptake in the presence of chloride in crypt AMV (80%) and lumen sodium- and chloride-dependent pHi recovery in crypt cells (96%).	Amiloride	7-16	glucose-6-phosphate isomerase	Rattus norvegicus	157-160
7750207-3	1995	The effects of amiloride on the modulation of uPA mRNA and protein induced by phorbol ester (PMA) and cycloheximide (CHX) were studied in four colon cancer cell lines, HCT116, KM12SM, LIM1215 and LS123.	Amiloride	15-24	plasminogen activator, urokinase	Homo sapiens	46-49
7750207-7	1995	Amiloride profoundly inhibited uPA mRNA production at concentrations between 0.1-1 mM in the presence or absence of PMA or CHX.	Amiloride	0-9	plasminogen activator, urokinase	Homo sapiens	31-34
7750207-10	1995	The inhibitory effects of amiloride on uPA gene expression reported in this paper may offer the prospect of developing new therapeutic approaches to the prevention of invasion and metastasis by adenocarcinomas.	Amiloride	26-35	plasminogen activator, urokinase	Homo sapiens	39-42
7744818-5	1995	Exchange of the hydrophobic domains of the Na+ channel alpha subunit by those of Mec-4 results in a functional ion channel with changed pharmacology for amiloride and benzamil and changed selectivity, conductance, gating, and voltage dependence.	Amiloride	153-162	Degenerin mec-4	Caenorhabditis elegans	81-86
7720639-3	1995	A spontaneous pHi recovery to 6.90 +/- 0.02 was inhibited by 300 microM amiloride.	Amiloride	72-81	glucose-6-phosphate isomerase	Rattus norvegicus	14-17
7720639-12	1995	To our knowledge, this is the first report showing the presence of an insulin-responsive and amiloride-sensitive Na+/H+ exchanger that regulates pHi by a Na(+)-specific and pHi-dependent mechanism in rat adipocytes.	Amiloride	93-102	glucose-6-phosphate isomerase	Rattus norvegicus	145-148
7720639-12	1995	To our knowledge, this is the first report showing the presence of an insulin-responsive and amiloride-sensitive Na+/H+ exchanger that regulates pHi by a Na(+)-specific and pHi-dependent mechanism in rat adipocytes.	Amiloride	93-102	glucose-6-phosphate isomerase	Rattus norvegicus	173-176
7603840-2	1995	Using the Xenopus laevis oocyte expression system we determined amiloride-sensitive Li+ uptake, a measure of Na+/H+ exchange, in oocytes injected with water or NHE-1 cRNA.	Amiloride	64-73	solute carrier family 9 member A1	Homo sapiens	160-165
7698616-6	1995	Blocking of Na+/H+ exchange (in the presence of HCO3-/CO2) by removal of Na+ or addition of amiloride eliminated the increase in aiNa and resulted in uncontrolled acidification of pHi.	Amiloride	92-101	glucose-6-phosphate isomerase	Homo sapiens	180-183
7722419-4	1995	Osmotic cell shrinkage was accompanied by an amiloride-sensitive increase in baseline pHi.	Amiloride	45-54	glucose-6-phosphate isomerase	Oryctolagus cuniculus	86-89
7603840-3	1995	Amiloride-sensitive Li+ uptake was three- to tenfold enhanced over control in NHE-1 cRNA-injected cells and was selectively inhibited by 0.01 microM HOE 694 [i.e. (3-methylsulphonyl-4-piperidinobenzoyl) guanidine methanesulphonate].	Amiloride	0-9	solute carrier family 9 member A1	Homo sapiens	78-83
7603840-5	1995	After acidification of oocytes from pH 7.7 to 6.8, amiloride-sensitive Li+ uptake was four- to tenfold higher in NHE-1 cRNA-injected cells than in controls.	Amiloride	51-60	solute carrier family 9 member A1	Homo sapiens	113-118
7857923-3	1995	It was shown by steric exclusion on Superose 6 column that amiloride increased the affinity of ANF for the native and truncated receptor, in contrast with ATP, whose destabilizing effect on ANF binding was abolished by truncation of the cytoplasmic domain.	Amiloride	59-68	natriuretic peptide A	Bos taurus	95-98
7534994-3	1995	In muscle-stripped or whole thickness preparations, serosal addition of the histamine H2 receptor agonist, dimaprit, caused cyclical increases in Isc, which were reduced by the chloride channel blocker, N-phenylanthranilic acid, but not by the sodium channel blocker amiloride.	Amiloride	267-276	histamine H2 receptor	Cavia porcellus	76-97
7736498-8	1995	The increase in steady state pHi was blocked by inhibitors of Na+/H+ exchange, amiloride (1 mM) and EIPA (10 microM).	Amiloride	79-88	glucose-6-phosphate isomerase	Oryctolagus cuniculus	29-32
7769606-5	1995	A Na+/H+ exchanger, demonstrated by NH4Cl exposure, was inhibited by amiloride and its analogues and stimulated by IBMX, phorbol esters, and epithelial growth factor (EGF).	Amiloride	69-78	pro-epidermal growth factor	Fundulus heteroclitus	141-165
7859941-7	1995	Even when the Na+/H+ exchanger was blocked by amiloride in nominally HCO3(-)-free solution, a rapid rise in pHi occurred during the first 3 min of reperfusion.	Amiloride	46-55	glucose-6-phosphate isomerase	Rattus norvegicus	108-111
7760016-8	1995	In these pattern-1 cells, pHi recovery was 95% complete within 200 s, and was blocked by removing Na+, or by applying 1 mM amiloride, 50 microM ethylisopropylamiloride (EIPA), or 50 microM hexamethyleneamiloride (HMA).	Amiloride	123-132	glucose-6-phosphate isomerase	Rattus norvegicus	26-29
7769606-5	1995	A Na+/H+ exchanger, demonstrated by NH4Cl exposure, was inhibited by amiloride and its analogues and stimulated by IBMX, phorbol esters, and epithelial growth factor (EGF).	Amiloride	69-78	pro-epidermal growth factor	Fundulus heteroclitus	167-170
7982995-4	1994	In both NMuMG and CHO cells expressing wild-type PDGF beta-receptors, PDGF B/B activated the amiloride-sensitive Na+/H+ exchanger.	Amiloride	93-102	LOW QUALITY PROTEIN: platelet-derived growth factor subunit B	Cricetulus griseus	49-58
27405553-4	1995	Stimulation of ferricyanide reduction by insulin and somatotrophin may be also the result of Na(+)/H(+) antiport activation which may be prevented by amiloride.	Amiloride	150-159	insulin	Homo sapiens	41-48
7840143-7	1995	In CHO cells, the osmotically induced delta pHi was only weakly sensitive to amiloride, suggesting that osmotic forces may activate an H+ transport system other than Na+/H+ exchange.	Amiloride	77-86	glucose-6-phosphate isomerase	Cricetulus griseus	44-47
8538854-7	1995	Furthermore, a daily administration of amiloride, a Na+/H+ exchanger inhibitor, to the ADR-NaC1 rats prevented the development of glomerular hypertrophy and sclerosis.	Amiloride	39-48	nucleus accumbens associated 1	Rattus norvegicus	91-95
7982995-4	1994	In both NMuMG and CHO cells expressing wild-type PDGF beta-receptors, PDGF B/B activated the amiloride-sensitive Na+/H+ exchanger.	Amiloride	93-102	LOW QUALITY PROTEIN: platelet-derived growth factor subunit B	Cricetulus griseus	70-76
7810647-10	1994	Apical amiloride did not alter Isc; however, after 48 h of treatment with hydrocortisone and insulin, an amiloride-sensitive Isc component became evident.	Amiloride	105-114	insulin	Canis lupus familiaris	93-100
7806569-1	1994	A highly selective, amiloride-sensitive, epithelial sodium channel from rat colon (rENaC), composed of three homologous subunits termed alpha, beta, and gamma rENaC, has been cloned by functional expression and was proposed to mediate electrogenic sodium reabsorption in aldosterone-responsive epithelia.	Amiloride	20-29	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	83-88
7806569-1	1994	A highly selective, amiloride-sensitive, epithelial sodium channel from rat colon (rENaC), composed of three homologous subunits termed alpha, beta, and gamma rENaC, has been cloned by functional expression and was proposed to mediate electrogenic sodium reabsorption in aldosterone-responsive epithelia.	Amiloride	20-29	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	159-164
7708483-3	1994	Inhibition of the Na+/H+ exchange by amiloride (2 mM) caused a significant decrease of pHi in nominally CO2/HCO3(-)-free saline.	Amiloride	37-46	glucose-6-phosphate isomerase	Rattus norvegicus	87-90
7858563-9	1994	Amiloride, an inhibitor of Na+/H+ exchange, decreased rates of protein synthesis in a concentration-dependent manner (12.5, 25, 50, 100 microM) but did not change cAMP content (5.25 +/- 0.11 pmol/mg protein) or expression of c-fos mRNA.	Amiloride	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	225-230
7929254-5	1994	Both C5a inactivation and S-2251 cleavage were inhibited by the plasmin inhibitor alpha 2-antiplasmin, the urokinase inhibitor amiloride, and by anti-urokinase antibodies.	Amiloride	127-136	complement C5a receptor 1	Homo sapiens	5-8
7938451-6	1994	Amiloride enhanced the effect of low-pH medium on pHi HSP synthesis and development of thermotolerance.	Amiloride	0-9	glucose-6-phosphate isomerase	Cricetulus griseus	50-53
7926038-1	1994	The modulation of urokinase plasminogen activator receptor (uPAR) gene expression by tumor necrosis factor alpha (TNF alpha), phorbol ester (PMA) and amiloride was studied in three colon cancer cell lines.	Amiloride	150-159	plasminogen activator, urokinase receptor	Homo sapiens	18-58
7926038-1	1994	The modulation of urokinase plasminogen activator receptor (uPAR) gene expression by tumor necrosis factor alpha (TNF alpha), phorbol ester (PMA) and amiloride was studied in three colon cancer cell lines.	Amiloride	150-159	plasminogen activator, urokinase receptor	Homo sapiens	60-64
7926038-2	1994	uPAR mRNA and protein were induced by TNF alpha and by PMA but were inhibited by amiloride at concentrations of 0.1 to 1 mM in the presence or absence of TNF alpha and PMA.	Amiloride	81-90	plasminogen activator, urokinase receptor	Homo sapiens	0-4
7524364-6	1994	The enhanced beta-responsiveness produced by IL-1 was eliminated by adding amiloride to block Na+/H+ exchange or protein kinase C inhibitors staurosporine (10 nM) and calphostin C (50 nM).	Amiloride	75-84	interleukin 1 beta	Homo sapiens	45-49
7929602-7	1994	The oxidoreductase inhibitor, amiloride, only slightly inhibited Fe uptake at the higher Tf concentration, suggesting that the second nonspecific process was not mediated by a diferric Tf reductase.	Amiloride	30-39	thioredoxin reductase 1	Homo sapiens	4-18
7929602-7	1994	The oxidoreductase inhibitor, amiloride, only slightly inhibited Fe uptake at the higher Tf concentration, suggesting that the second nonspecific process was not mediated by a diferric Tf reductase.	Amiloride	30-39	transferrin	Homo sapiens	89-91
7894528-0	1994	Intrastriatal infusion of amiloride increases rotations in 6-OHDA lesioned rats and "down-regulates" D2 receptors in the striatum and 5-HT2A receptors in the cortex.	Amiloride	26-35	5-hydroxytryptamine receptor 2A	Rattus norvegicus	134-140
8092257-3	1994	The proximal tubule expresses mRNA corresponding to two known Na+/H+ antiporter isoforms: NHE-3, an amiloride-resistant apical membrane Na+/H+ antiporter; and NHE-1, an amiloride-sensitive Na+/H+ antiporter found on most mammalian cells.	Amiloride	100-109	solute carrier family 9 member A3	Homo sapiens	90-95
8092257-3	1994	The proximal tubule expresses mRNA corresponding to two known Na+/H+ antiporter isoforms: NHE-3, an amiloride-resistant apical membrane Na+/H+ antiporter; and NHE-1, an amiloride-sensitive Na+/H+ antiporter found on most mammalian cells.	Amiloride	169-178	solute carrier family 9 member A1	Homo sapiens	159-164
8195209-7	1994	An increase in medium osmolality to 510 mosm in vascular smooth muscle cells, which express NHE-1, produced 45 and 64% stimulation of the amiloride-sensitive 22Na+ influx at base-line pHi and acid-loaded condition, respectively (p < 0.03 and < 0.01).	Amiloride	138-147	sodium/hydrogen exchanger 1	Sus scrofa	92-97
8048524-9	1994	Because amiloride (1 mM) inhibited Na(+)-dependent pHi recovery by 75%, Na+/H+ exchange appears to be present in the apical membrane.	Amiloride	8-17	glucose-6-phosphate isomerase	Rattus norvegicus	51-54
7964866-8	1994	The depolarization was Na+ dependent and amiloride sensitive (250 microM), both indicating an activation of an electrogenic sodium dependent transport system like the Na+/Ca2+ exchanger as a source of the depolarization.	Amiloride	41-50	solute carrier family 8 member A1	Homo sapiens	167-185
8074191-5	1994	The pHi recovery after normalization of pHe was very rapid, indicating that a prolonged exposure to a low pH stimulates pH-regulating mechanisms, and was inhibited by 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS) and amiloride or the removal of Na+.	Amiloride	227-236	glucose-6-phosphate isomerase	Rattus norvegicus	4-7
8089832-6	1994	The increment in pHi was blunted by the amiloride derivative EIPA, indicating that it was mediated by the Na+/H+ exchanger.	Amiloride	40-49	glucose-6-phosphate isomerase	Homo sapiens	17-20
8023890-2	1994	The recovery of ductal pHi from an acute acid load was Na+ dependent and inhibited by the amiloride analogue ethylisopropylamiloride with 50% inhibitory concentration 4.7 +/- 0.8 microM, indicating the presence of a Na(+)-H+ exchanger of the amiloride-insensitive type.	Amiloride	90-99	glucose-6-phosphate isomerase	Rattus norvegicus	23-26
8023890-2	1994	The recovery of ductal pHi from an acute acid load was Na+ dependent and inhibited by the amiloride analogue ethylisopropylamiloride with 50% inhibitory concentration 4.7 +/- 0.8 microM, indicating the presence of a Na(+)-H+ exchanger of the amiloride-insensitive type.	Amiloride	123-132	glucose-6-phosphate isomerase	Rattus norvegicus	23-26
7512958-5	1994	We have probed the pathways activated by SF and GM-CSF in suppression of active cell death (apoptosis) using two classes of inhibitors: Tyrphostins that are specific inhibitors of protein tyrosine kinase, and amiloride derivatives (5-(N,N-ethyl-n-isopropyl)amiloride and 5-(N,N-hexamethylene)amiloride) that have been designed as specific inhibitors of the Na+/H+ antiporter.	Amiloride	209-218	KIT ligand	Homo sapiens	41-43
8184013-5	1994	Inhibition of these enzymatic bands with specific antibodies against tissue-type plasminogen activator (tPA) and amiloride, an inhibitor for urokinase plasminogen activator (uPA), confirmed that these bands were tPA and uPA.	Amiloride	113-122	plasminogen activator, urokinase	Rattus norvegicus	141-172
8184013-5	1994	Inhibition of these enzymatic bands with specific antibodies against tissue-type plasminogen activator (tPA) and amiloride, an inhibitor for urokinase plasminogen activator (uPA), confirmed that these bands were tPA and uPA.	Amiloride	113-122	plasminogen activator, urokinase	Rattus norvegicus	174-177
8184013-5	1994	Inhibition of these enzymatic bands with specific antibodies against tissue-type plasminogen activator (tPA) and amiloride, an inhibitor for urokinase plasminogen activator (uPA), confirmed that these bands were tPA and uPA.	Amiloride	113-122	plasminogen activator, urokinase	Rattus norvegicus	220-223
8203529-2	1994	The structurally related amino acid, L-asparagine (Asn), stimulates the proliferative enzyme ornithine decarboxylase in colonocytes, an effect that is blocked by the Na+-H+ exchange inhibitor amiloride.	Amiloride	192-201	ornithine decarboxylase 1	Homo sapiens	93-116
8203529-5	1994	Removal of external Na+ caused reversible acidification; recovery of pHi from NH+4-induced acid load was Na+ dependent, amiloride inhibitable, and Cl-independent.	Amiloride	120-129	glucose-6-phosphate isomerase	Homo sapiens	69-72
8064688-7	1994	Most plasminogen activator activity present in preimplantation embryos appeared to be uPA, as it could be inhibited by anti-uPA antibody and a specific uPA inhibitor, amiloride, but not by anti-tPA antibody.	Amiloride	167-176	plasminogen activator, urokinase	Rattus norvegicus	86-89
7512958-5	1994	We have probed the pathways activated by SF and GM-CSF in suppression of active cell death (apoptosis) using two classes of inhibitors: Tyrphostins that are specific inhibitors of protein tyrosine kinase, and amiloride derivatives (5-(N,N-ethyl-n-isopropyl)amiloride and 5-(N,N-hexamethylene)amiloride) that have been designed as specific inhibitors of the Na+/H+ antiporter.	Amiloride	209-218	colony stimulating factor 2	Homo sapiens	48-54
8144586-8	1994	These data indicate that human placental diamine oxidase is identical to the human kidney amiloride-binding protein and that amiloride analogues may have wider physiological effects besides those on epithelial ion transport.	Amiloride	90-99	amine oxidase copper containing 1	Homo sapiens	41-56
8144587-8	1994	Examination of amiloride binding to bovine serum amine oxidase and porcine kidney diamine oxidase reveals dissociation constants of 196 and 9.1 microM, respectively.	Amiloride	15-24	primary amine oxidase, liver isozyme	Bos taurus	43-62
8144586-0	1994	Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues.	Amiloride	23-32	amine oxidase copper containing 1	Homo sapiens	0-15
8144586-0	1994	Diamine oxidase is the amiloride-binding protein and is inhibited by amiloride analogues.	Amiloride	69-78	amine oxidase copper containing 1	Homo sapiens	0-15
8144587-8	1994	Examination of amiloride binding to bovine serum amine oxidase and porcine kidney diamine oxidase reveals dissociation constants of 196 and 9.1 microM, respectively.	Amiloride	15-24	amine oxidase copper containing 1	Homo sapiens	82-97
8007573-4	1994	The thrombin-induced rise in pHi was Na+ dependent and amiloride sensitive, indicating that it was mediated by the Na+/H+ exchanger.	Amiloride	55-64	coagulation factor II, thrombin	Homo sapiens	4-12
8007573-4	1994	The thrombin-induced rise in pHi was Na+ dependent and amiloride sensitive, indicating that it was mediated by the Na+/H+ exchanger.	Amiloride	55-64	glucose-6-phosphate isomerase	Homo sapiens	29-32
8166230-5	1994	Apical ANG II-induced 22Na flux was prevented by preincubation with amiloride, ouabain, and the AT1 receptor antagonist losartan.	Amiloride	68-77	angiotensinogen	Homo sapiens	7-13
8183636-5	1994	The functional activity of an acid-extruding Na+/HCO3- cotransporter in human colonocytes was observed in response to the reintroduction of Na+ into amiloride-containing Na+/Cl(-)-free BBS.	Amiloride	149-158	solute carrier family 4 member 4	Homo sapiens	45-68
7514286-4	1994	In the presence of 500 mumol/l amiloride the corresponding values were: -72 +/- 2 mV (n = 34), pHi 7.00 +/- 0.07 (n = 5), 0.50 +/- 0.04 (n = 6), 0.04 +/- 0.01 (n = 11), 0.28 +/- 0.04 (n = 9) and -26 mV/pH-unit (n = 20/n = 5).	Amiloride	31-40	glucose-6-phosphate isomerase	Homo sapiens	95-98
7514286-5	1994	In the presence of 20 mmol/l propionate plus amiloride the corresponding values were: -61 +/- 2 mV (n = 27), pHi 6.72 +/- 0.06 (n = 5), 0.30 +/- 0.02 (n = 6), 0.06 +/- 0.01 (n = 5) and 0.40 +/- 0.02 (n = 8), respectively.	Amiloride	45-54	glucose-6-phosphate isomerase	Homo sapiens	109-112
7508184-5	1994	These observations indicate that a beta 2-agonist physiologically activates an amiloride-blockable NSC channel in FDLE through an increase in its sensitivity to [Ca2+]c, resulting in the development of a [Cl-]c dependency at a physiological [Ca2+]c associated with both an increase in [Ca2+]c and a reduction in [Cl-]c. A development of the [Cl-]c dependency and a reduction in [Cl-]c act as a second messenger of the beta-agonist signal transduction pathway in this Na(+)-transporting epithelium.	Amiloride	79-88	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	35-41
8290553-4	1994	In this study, we show that exposure of primary rat and human astrocytes to heat-activated HIV-1 virions, or to eukaryotically expressed HIV-1 and HIV-2 envelope glycoproteins (gp120) stimulates amiloride-sensitive Na+/H+ antiport, potassium conductance, and glutamate efflux.	Amiloride	195-204	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	177-182
7526625-7	1994	The pHi recovery following normalisation of pHe was very rapid, (indicating that a prolonged exposure to a low pH stimulates pH regulating mechanisms), and was inhibited by 4,4"-diisothiocyanatostilbene-2,2"-disulphonic acid (DIDS) and amiloride, or in the absence of Na+.	Amiloride	236-245	glucose-6-phosphate isomerase	Rattus norvegicus	4-7
7957545-0	1994	Insulin concentrations and insulin sensitivity after short-term amiloride in healthy subjects.	Amiloride	64-73	insulin	Homo sapiens	0-7
7957545-6	1994	The rates of glucose production and utilization were also similar, whereas the so-called insulin sensitivity index at the lower insulin concentration was significantly reduced (by about 15%) after amiloride.	Amiloride	197-206	insulin	Homo sapiens	89-96
7507013-5	1994	In contrast, the amiloride derivative 5-(N,N-dimethyl)-amiloride, more specific for Na+/H+ exchanges, slightly increased the IL-3-enhanced release.	Amiloride	17-26	interleukin 3	Homo sapiens	125-129
7957545-6	1994	The rates of glucose production and utilization were also similar, whereas the so-called insulin sensitivity index at the lower insulin concentration was significantly reduced (by about 15%) after amiloride.	Amiloride	197-206	insulin	Homo sapiens	128-135
7957545-0	1994	Insulin concentrations and insulin sensitivity after short-term amiloride in healthy subjects.	Amiloride	64-73	insulin	Homo sapiens	27-34
7957545-7	1994	Moreover, amiloride produced significantly higher fasting insulin and C-peptide concentrations, whereas fasting glucose and NEFA concentrations were unaltered.	Amiloride	10-19	insulin	Homo sapiens	58-65
7957545-1	1994	We have evaluated the short-term effects of amiloride on insulin action in vivo, since amiloride is known to impair insulin action in vitro.	Amiloride	44-53	insulin	Homo sapiens	57-64
7957545-7	1994	Moreover, amiloride produced significantly higher fasting insulin and C-peptide concentrations, whereas fasting glucose and NEFA concentrations were unaltered.	Amiloride	10-19	insulin	Homo sapiens	70-79
7957545-8	1994	In conclusion, these data suggest that short-term amiloride slightly impairs insulin sensitivity with respect to glucose uptake.	Amiloride	50-59	insulin	Homo sapiens	77-84
7957545-1	1994	We have evaluated the short-term effects of amiloride on insulin action in vivo, since amiloride is known to impair insulin action in vitro.	Amiloride	87-96	insulin	Homo sapiens	116-123
8307840-0	1993	Amiloride inhibits arginine vasopressin-induced decrease in fetal lung liquid secretion.	Amiloride	0-9	arginine vasopressin	Homo sapiens	28-39
8276370-8	1994	The diuretic responses to amiloride and potassium canrenoate were related to the activity of the renin-aldosterone system.	Amiloride	26-35	renin	Homo sapiens	97-102
8267614-3	1993	Transport of thyrotropin-releasing hormone was not affected by the presence of dipeptide glycylsarcosine, amino acid glycine, tripeptide thyrotropin-releasing hormone free acid as well as active transport inhibitors 2,4-dinitrophenol, sodium azide, ouabain, and amiloride.	Amiloride	262-271	thyrotropin releasing hormone	Homo sapiens	13-42
8244989-5	1993	Transport activity for NHE-2 was assayed by measuring amiloride-inhibitable 22Na+ influx following an acute intracellular acid load.	Amiloride	54-63	solute carrier family 9 member A2	Rattus norvegicus	23-28
8244989-6	1993	Pharmacological analyses revealed that NHE-2 had a relatively high affinity for amiloride and some of its analogues.	Amiloride	80-89	solute carrier family 9 member A2	Rattus norvegicus	39-44
8272382-1	1993	The human fibroblast, "amiloride-sensitive" Na/H exchanger (NHE1) was transfected into opossum kidney cells (OK cells) (OK/NHE1 cells).	Amiloride	23-32	solute carrier family 9 member A1	Homo sapiens	60-64
8246907-4	1993	This compound inhibits competitively NHE1 (Ki of 0.16 microM) with a much greater affinity than NHE2 and NHE3 (Ki of 5 microM and 650 microM, respectively) and therefore appears to be much more discriminative between these two classes of antiporter isoforms than the amiloride-related molecules.	Amiloride	267-276	solute carrier family 9 member A1	Homo sapiens	37-41
8246907-4	1993	This compound inhibits competitively NHE1 (Ki of 0.16 microM) with a much greater affinity than NHE2 and NHE3 (Ki of 5 microM and 650 microM, respectively) and therefore appears to be much more discriminative between these two classes of antiporter isoforms than the amiloride-related molecules.	Amiloride	267-276	solute carrier family 9 member A2	Homo sapiens	96-100
8246907-4	1993	This compound inhibits competitively NHE1 (Ki of 0.16 microM) with a much greater affinity than NHE2 and NHE3 (Ki of 5 microM and 650 microM, respectively) and therefore appears to be much more discriminative between these two classes of antiporter isoforms than the amiloride-related molecules.	Amiloride	267-276	solute carrier family 9 member A3	Homo sapiens	105-109
8270912-1	1993	M-1 cells, derived from a microdissected cortical collecting duct of a transgenic mouse, grown to confluence on a permeable support, develop a lumen-negative amiloride-sensitive transepithelial potential, reabsorb sodium, and secrete potassium.	Amiloride	158-167	cholinergic receptor, muscarinic 1, CNS	Mus musculus	0-3
8273285-5	1993	Amiloride (2 mM) also caused a decrease of photoresponse amplitude, which suggests that Na+/H+ exchange contributes to pHi regulation.	Amiloride	0-9	glucose-6-phosphate isomerase	Homo sapiens	119-122
8303861-0	1993	[The connection between insulin-dependent biosynthesis of cell membrane signal ATP with amiloride-sensitive Na+/H+-metabolism in human erythrocytes].	Amiloride	88-97	insulin	Homo sapiens	24-31
8251321-3	1993	While hydrochlorothiazide therapy alone or in combination with prostaglandin inhibitors or amiloride has been successful in children and adolescents, this is the first report of the successful use of hydrochlorothiazide and amiloride in an infant with congenital NDI.	Amiloride	224-233	arginine vasopressin receptor 2	Homo sapiens	263-266
8219018-3	1993	The finding that the number of c-Fos neurones decreased dramatically in the ms after treatment of the tongue with amiloride or after dissection of the chorda tympani suggests that the taste information of NaCl projects mainly to the ms.	Amiloride	114-123	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-36
8415663-2	1993	NHE3 was 39- and 160-fold more resistant to inhibition by amiloride and ethylisopropyl amiloride, respectively, than NHE1, the housekeeping Na+/H+ exchanger isoform.	Amiloride	58-67	solute carrier family 9 member A3	Homo sapiens	0-4
8272382-1	1993	The human fibroblast, "amiloride-sensitive" Na/H exchanger (NHE1) was transfected into opossum kidney cells (OK cells) (OK/NHE1 cells).	Amiloride	23-32	solute carrier family 9 member A1	Homo sapiens	123-127
8272382-8	1993	These results indicate that transfection of OK cells with human fibroblast NHE1 cDNA encoding an "amiloride-sensitive" form of the Na/H exchanger results in expression of basolaterally located "NHE1-related" transport activity.	Amiloride	98-107	solute carrier family 9 member A1	Homo sapiens	75-79
8272382-8	1993	These results indicate that transfection of OK cells with human fibroblast NHE1 cDNA encoding an "amiloride-sensitive" form of the Na/H exchanger results in expression of basolaterally located "NHE1-related" transport activity.	Amiloride	98-107	solute carrier family 9 member A1	Homo sapiens	194-198
8214077-4	1993	Exposure to 130 mM propionate in isosmotic medium causes a rapid decrease in pHi and activates pHi recovery via amiloride-sensitive Na-H exchange.	Amiloride	112-121	glucose-6-phosphate isomerase	Homo sapiens	95-98
8393860-0	1993	Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger.	Amiloride	53-62	solute carrier family 9 member A1	Rattus norvegicus	78-83
8214100-6	1993	Both cell populations demonstrated similar rates of Na+/H+ exchange, as assessed by peritubular Na(+)-dependent, amiloride-sensitive pHi recovery from an intracellular acid load.	Amiloride	113-122	glucose-6-phosphate isomerase	Oryctolagus cuniculus	133-136
8283968-3	1993	The first that was cloned is the amiloride sensitive isoform (NHE-1).	Amiloride	33-42	solute carrier family 9 member A1	Homo sapiens	62-67
8360289-7	1993	The rapid regulation of pHi seen following a transient alkalinization was not inhibited by amiloride or by removal of extracellular Na+, but was partially inhibited by DIDS and by removal of extracellular Cl-.	Amiloride	91-100	glucose-6-phosphate isomerase	Rattus norvegicus	24-27
8393860-0	1993	Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger.	Amiloride	53-62	solute carrier family 9 member A3	Rattus norvegicus	103-108
8393860-3	1993	Pharmacological analyses revealed that the activity of NHE-1 was substantially more sensitive to inhibition by amiloride and its analogues than NHE-3.	Amiloride	111-120	solute carrier family 9 member A1	Rattus norvegicus	55-60
7687162-4	1993	To further explore the mechanisms responsible for platelet alpha-granule secretion, we have shown that inhibition of Na+/H+ exchange by either acidification of the extracellular medium or amiloride treatment blocked ADP-induced P-selectin expression.	Amiloride	188-197	selectin P	Homo sapiens	228-238
8394691-13	1993	If the extrusion of H+ by the Na+/H+ exchanger was inhibited by amiloride (0.5 mmol/l) during the NH4Cl application, the decrease in pHi was amplified and the formation of urea was significantly inhibited.	Amiloride	64-73	glucose-6-phosphate isomerase	Rattus norvegicus	133-136
8393012-3	1993	Na/H exchange was assayed as the Na-dependent, amiloride-sensitive component of pHi recovery from an acid load induced by a pulse of NH3/NH4-containing solution.	Amiloride	47-56	glucose-6-phosphate isomerase 1	Mus musculus	80-83
8393012-9	1993	In addition, a putative Na/HCO3 cotransport system was monitored as a Na-dependent, amiloride-insensitive pHi recovery mechanisms that was inhibited by 200 microM H2DIDS.	Amiloride	84-93	glucose-6-phosphate isomerase 1	Mus musculus	106-109
8393628-3	1993	Amiloride, at a concentration that inhibits Na-H exchange, produced an identical inhibition of Na transport and abolished the ANP-induced decrease in Na absorption.	Amiloride	0-9	natriuretic peptides A	Sus scrofa	126-129
8391430-4	1993	ANP also inhibited Na/H exchange through an amiloride-sensitive mechanism, as shown by intracellular pH measurement in cells challenged or not by an acid or alkaline load.	Amiloride	44-53	natriuretic peptide A	Homo sapiens	0-3
7685025-7	1993	Stable expression of NHE-2 in PS120 fibroblasts confirmed that NHE-2 is a functional Na+/H+ exchanger which is defined by amiloride-sensitive Na+-dependent alkalinization of acid-loaded cells.	Amiloride	122-131	solute carrier family 9 member A2	Homo sapiens	21-26
8512555-6	1993	Similarly, NHE2/L143F and Y144F (mimicking AR300) increased the resistance to both amiloride and EIPA by 10-fold.	Amiloride	83-92	LOW QUALITY PROTEIN: sodium/hydrogen exchanger 2	Oryctolagus cuniculus	11-15
8512555-1	1993	A family of Na+/H+ exchanger isoforms (called NHE1, NHE2, and NHE3) which exhibits a wide range of amiloride sensitivity has recently been cloned and characterized.	Amiloride	99-108	sodium/hydrogen exchanger 1	Oryctolagus cuniculus	46-50
8512555-1	1993	A family of Na+/H+ exchanger isoforms (called NHE1, NHE2, and NHE3) which exhibits a wide range of amiloride sensitivity has recently been cloned and characterized.	Amiloride	99-108	LOW QUALITY PROTEIN: sodium/hydrogen exchanger 2	Oryctolagus cuniculus	52-56
8512555-1	1993	A family of Na+/H+ exchanger isoforms (called NHE1, NHE2, and NHE3) which exhibits a wide range of amiloride sensitivity has recently been cloned and characterized.	Amiloride	99-108	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	62-66
8512555-2	1993	A part of the domain, which determines amiloride sensitivity in the epithelial Na+/H+ exchanger isoform, NHE2, was identified by site-directed mutagenesis and functional studies using cDNAs stably expressed in a fibroblast cell line.	Amiloride	39-48	LOW QUALITY PROTEIN: sodium/hydrogen exchanger 2	Oryctolagus cuniculus	105-109
8512555-3	1993	It has previously been reported that AR300, an amiloride resistant mutant of the ubiquitous Na+/H+ exchanger isoform, NHE1, is 30-fold more resistant to methylpropyl amiloride (MPA) compared to NHE1 and contains a single amino acid substitution of L167F in the fourth putative transmembrane helix, which corresponds to L143 in NHE2.	Amiloride	47-56	sodium/hydrogen exchanger 1	Oryctolagus cuniculus	118-122
8512555-3	1993	It has previously been reported that AR300, an amiloride resistant mutant of the ubiquitous Na+/H+ exchanger isoform, NHE1, is 30-fold more resistant to methylpropyl amiloride (MPA) compared to NHE1 and contains a single amino acid substitution of L167F in the fourth putative transmembrane helix, which corresponds to L143 in NHE2.	Amiloride	47-56	sodium/hydrogen exchanger 1	Oryctolagus cuniculus	194-198
8512555-3	1993	It has previously been reported that AR300, an amiloride resistant mutant of the ubiquitous Na+/H+ exchanger isoform, NHE1, is 30-fold more resistant to methylpropyl amiloride (MPA) compared to NHE1 and contains a single amino acid substitution of L167F in the fourth putative transmembrane helix, which corresponds to L143 in NHE2.	Amiloride	47-56	LOW QUALITY PROTEIN: sodium/hydrogen exchanger 2	Oryctolagus cuniculus	327-331
8512555-5	1993	NHE2/L143F (mimicking NHE3) increased the IC50 for amiloride by 5-fold and for ethylisopropyl amiloride (EIPA) by 20-fold.	Amiloride	51-60	LOW QUALITY PROTEIN: sodium/hydrogen exchanger 2	Oryctolagus cuniculus	0-4
8512555-5	1993	NHE2/L143F (mimicking NHE3) increased the IC50 for amiloride by 5-fold and for ethylisopropyl amiloride (EIPA) by 20-fold.	Amiloride	51-60	sodium/hydrogen exchanger 3	Oryctolagus cuniculus	22-26
7685025-7	1993	Stable expression of NHE-2 in PS120 fibroblasts confirmed that NHE-2 is a functional Na+/H+ exchanger which is defined by amiloride-sensitive Na+-dependent alkalinization of acid-loaded cells.	Amiloride	122-131	solute carrier family 9 member A2	Homo sapiens	63-68
8223707-7	1993	The drugs amiloride and SITS (4-acetamido-4"-isothiocyanatostilbene-2,2"-disulfonic acid) also completely inhibited ruffle formation, suggesting that ion transport was an early consequence of HGF/SF binding and that these transport effects had a major role in the cytoskeletal changes leading to circular ruffle formation.	Amiloride	10-19	hepatocyte growth factor	Homo sapiens	192-198
8495419-7	1993	This level of inhibition represents 20- and 100-fold increases in potency, respectively, relative to the 6-7 microM potencies reported for amiloride and 4-chlorophenylguanidine, the two most potent selective synthetic uPA inhibitors previously described.	Amiloride	139-148	plasminogen activator, urokinase	Homo sapiens	218-221
8494532-6	1993	Both IL8 (class I)- and TNF (class II)-stimulated Cl- efflux exhibited similar sensitivity to inhibition by different types of ion transport inhibitors [ethacrynic acid (EA), amiloride, 4-acetamido-4"-isothiocyanatostilbene-2,2"-disulfonic acid, anthracene-9-carboxylic acid, and 4-4"-diisothiocyanatostilbene-2,2"-disulfonic acid].	Amiloride	175-184	C-X-C motif chemokine ligand 8	Homo sapiens	5-8
8210461-1	1993	It has previously been reported that amiloride, a diuretic drug, sensitizes cells to hyperthermia by inhibiting the Na+/H+ exchange through the plasma membrane and thus decreasing the intracellular pH (pHi), particularly in a low extracellular pH (pHe) environment.	Amiloride	37-46	glucose-6-phosphate isomerase	Homo sapiens	202-205
8210461-2	1993	In the present study, the efficacy of 5-(N-ethyl-N-isopropyl) amiloride (EIPA), an analog of amiloride, to lower the pHi and sensitize tumor cells to hyperthermia was investigated.	Amiloride	62-71	glucose-6-phosphate isomerase	Homo sapiens	117-120
8210461-3	1993	It was observed that 10 microM EIPA was as effective as 500 microM amiloride to lower the pHi and to increase the thermal sensitivity of SCK tumor cells in vitro.	Amiloride	67-76	glucose-6-phosphate isomerase	Homo sapiens	90-93
8392797-10	1993	Addition of amiloride (10 microM) to the apical bath before AVP or forskolin stimulation of ISC eliminates the late increase of ISC.	Amiloride	12-21	arginine vasopressin	Homo sapiens	60-63
8389452-0	1993	A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis.	Amiloride	100-109	solute carrier family 9 member A1	Homo sapiens	47-51
8389452-1	1993	The diuretic drug amiloride and its 5-amino substitute N5-methyl-N5-propylamiloride (MPA) are potent inhibitors of the growth factor-activatable Na+/H+ exchanger isoform 1 (NHE1).	Amiloride	18-27	solute carrier family 9 member A1	Homo sapiens	145-171
8389452-1	1993	The diuretic drug amiloride and its 5-amino substitute N5-methyl-N5-propylamiloride (MPA) are potent inhibitors of the growth factor-activatable Na+/H+ exchanger isoform 1 (NHE1).	Amiloride	18-27	solute carrier family 9 member A1	Homo sapiens	173-177
8389452-9	1993	Mutating a close residue, Phe-165--> Tyr, increased by 40-fold the Ki for amiloride and reduced Na+ transport rate 3- to 4-fold, indicating that we have identified a critical domain of the NHE molecule that controls amiloride binding and Na+ transport.	Amiloride	77-86	solute carrier family 9 member C1	Homo sapiens	192-195
8389452-9	1993	Mutating a close residue, Phe-165--> Tyr, increased by 40-fold the Ki for amiloride and reduced Na+ transport rate 3- to 4-fold, indicating that we have identified a critical domain of the NHE molecule that controls amiloride binding and Na+ transport.	Amiloride	219-228	solute carrier family 9 member C1	Homo sapiens	192-195
8389452-10	1993	Interestingly, the epithelial amiloride-resistant NHE isoforms that occurred naturally possess some of the amino acid substitutions described here.	Amiloride	30-39	solute carrier family 9 member C1	Homo sapiens	50-53
8494532-6	1993	Both IL8 (class I)- and TNF (class II)-stimulated Cl- efflux exhibited similar sensitivity to inhibition by different types of ion transport inhibitors [ethacrynic acid (EA), amiloride, 4-acetamido-4"-isothiocyanatostilbene-2,2"-disulfonic acid, anthracene-9-carboxylic acid, and 4-4"-diisothiocyanatostilbene-2,2"-disulfonic acid].	Amiloride	175-184	tumor necrosis factor	Homo sapiens	24-27
8229818-12	1993	Application of Na(+)-H+ exchanger inhibitors, amiloride or ethylisopropyl-amiloride (EIPA), abolished the recovery of pHi and shortening during maintained exposure to lactate at pHo 7.4 and caused an additional acidosis during maintained application of lactate at pHo 6.4.	Amiloride	46-55	glucose-6-phosphate isomerase	Rattus norvegicus	118-121
8388649-9	1993	In contrast, amiloride slowed pHi recovery after an exogenous acid load.	Amiloride	13-22	glucose-6-phosphate isomerase	Rattus norvegicus	30-33
8476023-1	1993	These studies examined the effects of protein kinase C activation and calmodulin inhibition on the amiloride-sensitive NHE-1 isoform of the Na(+)-H+ exchanger in defined host cells.	Amiloride	99-108	calmodulin 1	Homo sapiens	70-80
8083497-10	1993	10(-6) M amiloride abolished responses to AVP [fetuses 62 +/- 1 days of gestation; 93.4 +/- 18.5 g (SD) body weight, n = 30; rates, succeeding hours; AVP alone, 1.78 +/- 0.22, 0.48 +/- 0.09, 0.16 +/- 0.99 (P < 0.01-0.0005); AVP with amiloride, 1.15 +/- 0.07, 0.93 +/- 0.10, 0.86 +/- 0.08 (no significant fall) ml/kg body weight per h].	Amiloride	9-18	vasopressin-neurophysin 2-copeptin	Cavia porcellus	42-45
8083497-10	1993	10(-6) M amiloride abolished responses to AVP [fetuses 62 +/- 1 days of gestation; 93.4 +/- 18.5 g (SD) body weight, n = 30; rates, succeeding hours; AVP alone, 1.78 +/- 0.22, 0.48 +/- 0.09, 0.16 +/- 0.99 (P < 0.01-0.0005); AVP with amiloride, 1.15 +/- 0.07, 0.93 +/- 0.10, 0.86 +/- 0.08 (no significant fall) ml/kg body weight per h].	Amiloride	9-18	vasopressin-neurophysin 2-copeptin	Cavia porcellus	150-153
8083497-10	1993	10(-6) M amiloride abolished responses to AVP [fetuses 62 +/- 1 days of gestation; 93.4 +/- 18.5 g (SD) body weight, n = 30; rates, succeeding hours; AVP alone, 1.78 +/- 0.22, 0.48 +/- 0.09, 0.16 +/- 0.99 (P < 0.01-0.0005); AVP with amiloride, 1.15 +/- 0.07, 0.93 +/- 0.10, 0.86 +/- 0.08 (no significant fall) ml/kg body weight per h].	Amiloride	9-18	vasopressin-neurophysin 2-copeptin	Cavia porcellus	150-153
8476023-1	1993	These studies examined the effects of protein kinase C activation and calmodulin inhibition on the amiloride-sensitive NHE-1 isoform of the Na(+)-H+ exchanger in defined host cells.	Amiloride	99-108	solute carrier family 9 member A1	Homo sapiens	119-124
8385038-3	1993	At 250 microU/ml it caused a 4.2 +/- 0.8% increase, and at 500 microU/ml insulin caused a 17.7 +/- 1.4% increase in Na+, K(+)-ATPase activity that was completely inhibited by amiloride (1 mmol/l).	Amiloride	175-184	insulin	Oryctolagus cuniculus	73-80
8473054-8	1993	Pre-treatment of cells for 2 hr with non-toxic concentrations of pertussis toxin (PT) or amiloride resulted in a 50% inhibition of chemotaxis to GM-CSF.	Amiloride	89-98	colony stimulating factor 2	Homo sapiens	145-151
8473054-9	1993	Therefore, GM-CSF, through PT- and amiloride-sensitive signal pathways, is a potent attractant for melanoma cells, the response to which is additive to that of other attractants.	Amiloride	35-44	colony stimulating factor 2	Homo sapiens	11-17
8385038-4	1993	Human insulin-like growth factor I (600 pmol/l) caused an 18.0 +/- 1.0% increase in Na+, K(+)-ATPase activity that was inhibited by amiloride.	Amiloride	132-141	insulin like growth factor 1	Homo sapiens	6-34
7689888-2	1993	This novel effect of EGF was markedly decreased by various tyrosine kinase inhibitors, such as alpha-cyano-3-ethoxy-4-hydroxy-5-phenyl-thiomethyl cinnamamide, amiloride and biochanin A.	Amiloride	159-168	epidermal growth factor	Homo sapiens	21-24
8383969-10	1993	Ionomycin induced an elevation of [Ca2+]i that was accompanied by a concomitant increase in pHi, which was Na(+)-dependent and amiloride-sensitive.	Amiloride	127-136	glucose-6-phosphate isomerase	Homo sapiens	92-95
8100377-6	1993	The application of N-methyl-D-aspartate (NMDA) resulted in a large, dose-dependent decrease of [Ca2+]e, which was sensitive to APV and MK-801, but was only slightly reduced by nimodipine and amiloride.	Amiloride	191-200	carbonic anhydrase 2	Oryctolagus cuniculus	96-99
8381657-0	1993	Therapeutic potential of analogues of amiloride: inhibition of the regulation of intracellular pH as a possible mechanism of tumour selective therapy.	Amiloride	38-47	glucose-6-phosphate isomerase 1	Mus musculus	95-97
8381657-3	1993	Amiloride and its analogues DMA (5-(N,N-dimethyl)amiloride), MIBA (5-(N-methyl-N-isobutyl)amiloride) and EIPA (5-(N-ethyl-N-isopropyl)amiloride) are known to inhibit the Na+/H+ antiport and therefore decrease the cells ability to regulate pHi.	Amiloride	0-9	glucose-6-phosphate isomerase 1	Mus musculus	239-242
8389731-0	1993	Opposite effects of amiloride and amiloride analogues on activation of natural killer cytotoxicity by the phorbol ester TPA and gamma-interferon.	Amiloride	20-29	plasminogen activator, tissue type	Homo sapiens	120-123
8389731-0	1993	Opposite effects of amiloride and amiloride analogues on activation of natural killer cytotoxicity by the phorbol ester TPA and gamma-interferon.	Amiloride	34-43	plasminogen activator, tissue type	Homo sapiens	120-123
8389731-1	1993	Amiloride, a K(+)-sparing diuretic used as an Na+/H+ exchange inhibitor, blocked the activation of human natural killer (NK) activity against K562 cells by either the phorbol ester TPA or gamma-interferon.	Amiloride	0-9	plasminogen activator, tissue type	Homo sapiens	181-184
8383106-0	1993	Amiloride blocks the inhibition of fetal lung liquid secretion caused by AVP but not by asphyxia.	Amiloride	0-9	vasopressin-neurophysin 2-copeptin	Ovis aries	73-76
8381606-5	1993	However, bath amiloride significantly reduced the initial rate of pHi recovery after acidification (0.70 pH U/min in control vs. 0.39 pH U/min with amiloride).	Amiloride	14-23	glucose-6-phosphate isomerase	Oryctolagus cuniculus	66-69
8224063-3	1993	Addition of 4,4"-diisothiocyanatostilbene-2,2"-disulphonic acid (DIDS) or amiloride decreased pHi, as did removal of extracellular Na+, while removal of extracellular Cl- was followed by an increase in pHi.	Amiloride	74-83	glucose-6-phosphate isomerase	Rattus norvegicus	94-97
8224063-3	1993	Addition of 4,4"-diisothiocyanatostilbene-2,2"-disulphonic acid (DIDS) or amiloride decreased pHi, as did removal of extracellular Na+, while removal of extracellular Cl- was followed by an increase in pHi.	Amiloride	74-83	glucose-6-phosphate isomerase	Rattus norvegicus	202-205
8224063-5	1993	Regulation of pHi was impaired when either amiloride or DIDS was added or Cl- was removed.	Amiloride	43-52	glucose-6-phosphate isomerase	Rattus norvegicus	14-17
8224063-7	1993	The rapid regulation of pHi normally seen following a transient alkalinisation was not inhibited by amiloride or removal of Na+, but was partially inhibited by DIDS and by the absence of extracellular Cl-.	Amiloride	100-109	glucose-6-phosphate isomerase	Rattus norvegicus	24-27
1341275-8	1992	Amiloride (400 microM) completely abolished serum-stimulated ODC activity and inhibited difluoromethylornithine (DMFO)-stimulated putrescine uptake by 56%.	Amiloride	0-9	ornithine decarboxylase 1	Homo sapiens	61-64
1336929-6	1992	Amiloride (1 mM) acidified pHi but DIDS (1 mM) treatment, HCO3(-)-free condition, 1 mM ouabain, 50 mM K+, and 2 mM BaCl2 failed to change pHi.	Amiloride	0-9	glucose-6-phosphate isomerase	Bos taurus	27-30
8437890-7	1993	In the presence of amiloride, the response to both apical and basolateral bradykinin was reduced by > 50% in 8 out of 18 layers, and the mean response was reduced by approximately 25%.	Amiloride	19-28	kininogen 1	Homo sapiens	74-84
1335884-4	1992	Cell acidifications (pHi to 6.65, n = 8) induced by the "NH(4+)-loading" method were rapidly followed by a Na(+)-dependent, amiloride-inhibitable pHi recovery.	Amiloride	124-133	glucose-6-phosphate isomerase	Bos taurus	21-24
1419026-8	1992	In unstimulated cultures, Na+ absorption (amiloride-inhibited portion of Isc) was 10.7 +/- 3.3. muamp/cm2 (n = 10) and was reduced by 79% in the presence of NDGA (n = 10), suggesting that inhibition of the lipoxygenase pathway was associated with inhibition of Na+ absorption.	Amiloride	42-51	polyunsaturated fatty acid lipoxygenase ALOX15	Oryctolagus cuniculus	206-218
1443100-2	1992	The amiloride analogue 5-(N-ethyl-N-isopropyl)amiloride (EIPA), an inhibitor of the Na(+)-H+ antiporter, inhibited extracellular IL-1 beta.	Amiloride	4-13	interleukin 1 beta	Homo sapiens	129-138
1335884-4	1992	Cell acidifications (pHi to 6.65, n = 8) induced by the "NH(4+)-loading" method were rapidly followed by a Na(+)-dependent, amiloride-inhibitable pHi recovery.	Amiloride	124-133	glucose-6-phosphate isomerase	Bos taurus	146-149
1335884-8	1992	Consistent with this posit, the reintroduction of Na+ to cells perfused in the absence of the cation with a HCO3(-)-containing, amiloride-complemented solution resulted in a gradual recovery from the acidic pHi induced by the baseline conditions (n = 6).	Amiloride	128-137	glucose-6-phosphate isomerase	Bos taurus	207-210
1522132-3	1992	In the presence of Na and amiloride to inhibit Na/H exchange, the recovery of pHi after CO2 entry and CO2 exit were found to depend in part on HCO3 entry and exit, respectively.	Amiloride	26-35	glucose-6-phosphate isomerase	Homo sapiens	78-81
1327925-3	1992	Na+/H+ antiport activity (measured as the rate of amiloride-sensitive Na+ influx at pHi = 6.4, extracellular pH = 8.0, and [Na+] = 1 mM) was elevated significantly in IDDM patients with nephropathy compared with IDDM patients without nephropathy and nondiabetic control subjects (13.35 +/- 3.8 vs. 8.54 +/- 2.0 vs. 7.33 +/- 2.3 nmol Na+.mg protein-1.min-1; P less than 0.006 and P less than 0.001, respectively).	Amiloride	50-59	CD59 molecule (CD59 blood group)	Homo sapiens	350-355
1328110-6	1992	Steady-state pHi was reduced by addition of 0.5 mmol/l amiloride, a Na+/H+ exchange blocker (-.16 pH U for FBCE, -.18 for CBCE) or removal of Na+ (-.47 pH U for FBCE, -.51 for CBCE).	Amiloride	55-64	glucose-6-phosphate isomerase	Bos taurus	13-16
1338103-11	1992	Stimulation of the exchanger under isosmotic conditions by 25 nM 4 beta-phorbol 12-myristate 13-acetate (PMA) and 0.1 mM vanadate resulted in an amiloride-sensitive pHi increase of about 0.08 pH units.	Amiloride	145-154	glucose-6-phosphate isomerase	Rattus norvegicus	165-168
1335129-1	1992	To expel the excess protons generated during a cellular acidification and to fully recover basal intracellular pH (pHi), cardiac cells rely on the amiloride-sensitive Na/H antiport.	Amiloride	147-156	glucose-6-phosphate isomerase	Rattus norvegicus	115-118
1335129-2	1992	We report that rat single ventricular cardiomyocytes, loaded with the fluorescent pH indicator Snarf-1 and treated with inhibitors of the Na/H antiport, amiloride or its analogues, partially restored their pHi through a bicarbonate-dependent mechanism following an acidosis (imposed by the ammonia-pulse technique).	Amiloride	153-162	glucose-6-phosphate isomerase	Rattus norvegicus	206-209
1335129-3	1992	In the presence of ethylisopropylamiloride (10 microM) or amiloride (1 mM) and 25 mM bicarbonate in the extracellular solution, the average time that cells needed to recover half of their pHi, following the removal of 20 mM NH4Cl, was 3.4 min, while the rate of proton efflux was calculated to be 2.0 mM/min.	Amiloride	33-42	glucose-6-phosphate isomerase	Rattus norvegicus	188-191
1382419-6	1992	This suggested that amiloride-blockable NSC channel activity and ion permeability are modulated by changes in [Ca2+]i near physiologic membrane potentials and a beta adrenergic agonist increases [Ca2+]i to more than 1 microM (unlike other epithelial including adult alveolar cells) which is associated with activation the NSC channel.	Amiloride	20-29	amyloid beta precursor protein	Homo sapiens	159-165
1357983-6	1992	To explore further a cause of the attenuated natriuretic effect of pramipexole in the young, we studied the effect of a selective DA1-receptor agonist, fenoldopam, on amiloride-sensitive 22Na+ uptake in renal brush-border membrane vesicles.	Amiloride	167-176	RT1 class II, locus Da	Rattus norvegicus	130-133
1324151-9	1992	1,25-(OH)2D3 caused a dose-dependent decrease in pHi in CaCo-2 cells, as assessed by the fluorescent dye BCECF, which was not observed in cells suspended in Na(+)-free buffer or pretreated with amiloride, indicating that the secosteroid inhibited Na(+)-H+ exchange.	Amiloride	194-203	glucose-6-phosphate isomerase	Homo sapiens	49-52
1329529-8	1992	However, addition of 10(-4) M amiloride caused pHi to decrease to 7.29 +/- 0.18 (P less than 0.01).	Amiloride	30-39	glucose-6-phosphate isomerase	Oryctolagus cuniculus	47-50
1329533-7	1992	These results indicate that insulin increases Na absorption in the distal nephron by increasing the open probability of the amiloride-blockable Na channel.	Amiloride	124-133	insulin	Homo sapiens	28-35
1324935-8	1992	The decreased ET-1 secretion caused by C-ANP 4-23 was reversed by 8-bromo-cAMP or amiloride, which prevents ANP-induced inhibition of cAMP.	Amiloride	82-91	endothelin 1	Bos taurus	14-18
1331976-5	1992	Recovery of pHi following a NH+4/NH3 pulse could be reduced by either 100 microM SCH 28080 or 1 mM amiloride, or by removing extracellular Na+.	Amiloride	99-108	glucose-6-phosphate isomerase	Homo sapiens	12-15
1396416-11	1992	Amiloride, a Na(+)-H+ exchange inhibitor, decreased the pHi of both DBA and C57 astrocytes more in HEPES HBSS than in HCO3- HBSS.	Amiloride	0-9	glucose-6-phosphate isomerase 1	Mus musculus	56-59
1331976-6	1992	The inhibitory effects of SCH 28080 and amiloride were additive, demonstrating the involvement of a gastric-like H+/K(+)-ATPase and a Na+/H+ exchanger in regulating pHi.	Amiloride	40-49	glucose-6-phosphate isomerase	Homo sapiens	165-168
1504097-11	1992	pHi recovery to the initial value was caused mainly by amiloride-sensitive Na+/H+ exchange and to a lesser extent by an amiloride-insensitive system, which was not studied in detail.	Amiloride	55-64	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-3
1504097-11	1992	pHi recovery to the initial value was caused mainly by amiloride-sensitive Na+/H+ exchange and to a lesser extent by an amiloride-insensitive system, which was not studied in detail.	Amiloride	120-129	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-3
1503904-2	1992	Cell killing is enhanced when these agents are used in combination with compounds (amiloride, 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS)) which inhibit the membrane-based exchangers responsible for the regulation of intracellular pH (pHi).	Amiloride	83-92	glucose-6-phosphate isomerase 1	Mus musculus	247-250
1320038-1	1992	The present study was performed to investigate the regulation of cytosolic pH (pHi) and DNA synthesis by parathyroid hormone(PTH) and PTH-related peptide (PTHrP) in osteoblasts, using osteoblastic osteosarcoma cells, UMR-106 which possessed PTH-responsive dual signal transduction systems (cAMP-dependent protein kinase (PKA) and calcium/protein kinase C [Ca/PKC]) and amiloride-inhibitable Na+/H+ exchange system.	Amiloride	369-378	parathyroid hormone like hormone	Homo sapiens	155-160
1512278-13	1992	Amiloride, a Na(+)-Ca2+ exchange inhibitor, also depressed the maxima of the concentration-response curves to ET-1 with an IC50 of 0.45 +/- 0.05 mM (n = 4).	Amiloride	0-9	endothelin 1	Rattus norvegicus	110-114
1320038-3	1992	Pretreatment with amiloride (0.3 mM) mostly blocked dbcAMP- and Sp-cAMPS-induced decrease in pHi but did not affect calcium ionophore-induced decrease in pHi.	Amiloride	18-27	glucose-6-phosphate isomerase	Homo sapiens	93-96
1320038-4	1992	In the presence of amiloride, PTH and PTHrP caused a transient decrease in pHi, which was similar to the pattern of calcium ionophore-induced change in pHi.	Amiloride	19-28	parathyroid hormone like hormone	Homo sapiens	38-43
1320038-4	1992	In the presence of amiloride, PTH and PTHrP caused a transient decrease in pHi, which was similar to the pattern of calcium ionophore-induced change in pHi.	Amiloride	19-28	glucose-6-phosphate isomerase	Homo sapiens	75-78
1320038-4	1992	In the presence of amiloride, PTH and PTHrP caused a transient decrease in pHi, which was similar to the pattern of calcium ionophore-induced change in pHi.	Amiloride	19-28	glucose-6-phosphate isomerase	Homo sapiens	152-155
1591007-4	1992	In this study, we examine the role of amiloride for the regulation of AM-derived interleukin (IL)-8, tumor necrosis factor (TNF), IL-6, and IL-1 beta.	Amiloride	38-47	C-X-C motif chemokine ligand 8	Homo sapiens	81-99
1319688-3	1992	Utilizing the NH+4-loading technique to acid load cells, we found that pHi decreased from approximately 7.2 to approximately 6.6; subsequent alkalinization of normal and CF ciliated cells required Na+ and was independent of Cl- but was blocked by amiloride (500 microM).	Amiloride	247-256	glucose-6-phosphate isomerase	Homo sapiens	71-74
1591007-4	1992	In this study, we examine the role of amiloride for the regulation of AM-derived interleukin (IL)-8, tumor necrosis factor (TNF), IL-6, and IL-1 beta.	Amiloride	38-47	tumor necrosis factor	Homo sapiens	101-122
1591007-4	1992	In this study, we examine the role of amiloride for the regulation of AM-derived interleukin (IL)-8, tumor necrosis factor (TNF), IL-6, and IL-1 beta.	Amiloride	38-47	interleukin 6	Homo sapiens	130-134
1591007-4	1992	In this study, we examine the role of amiloride for the regulation of AM-derived interleukin (IL)-8, tumor necrosis factor (TNF), IL-6, and IL-1 beta.	Amiloride	38-47	interleukin 1 beta	Homo sapiens	140-149
1591007-5	1992	Amiloride in concentrations of 10(-4) to 10(-6) M, concentrations capable of being achieved in the distal airways via nebulization, were shown to inhibit lipopolysaccharide-stimulated, AM-derived IL-8 and TNF in both a time- and dose-dependent fashion.	Amiloride	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	196-200
1591007-5	1992	Amiloride in concentrations of 10(-4) to 10(-6) M, concentrations capable of being achieved in the distal airways via nebulization, were shown to inhibit lipopolysaccharide-stimulated, AM-derived IL-8 and TNF in both a time- and dose-dependent fashion.	Amiloride	0-9	tumor necrosis factor	Homo sapiens	205-208
1591007-6	1992	In addition, 5-(N,N-hexamethylene) amiloride hydrochloride, an amiloride analogue with specific sodium channel antiport inhibition, resulted in a similar dose-dependent suppression of lipopolysaccharide-stimulated, AM-derived IL-8 production.	Amiloride	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	226-230
1591007-7	1992	Furthermore, the suppressive effect of amiloride appeared to be at the level of mRNA for IL-8, TNF, IL-1 beta, and IL-6, whereas steady-state levels of beta-actin mRNA remained unaltered.	Amiloride	39-48	C-X-C motif chemokine ligand 8	Homo sapiens	89-93
1591007-7	1992	Furthermore, the suppressive effect of amiloride appeared to be at the level of mRNA for IL-8, TNF, IL-1 beta, and IL-6, whereas steady-state levels of beta-actin mRNA remained unaltered.	Amiloride	39-48	tumor necrosis factor	Homo sapiens	95-98
1591007-7	1992	Furthermore, the suppressive effect of amiloride appeared to be at the level of mRNA for IL-8, TNF, IL-1 beta, and IL-6, whereas steady-state levels of beta-actin mRNA remained unaltered.	Amiloride	39-48	interleukin 1 beta	Homo sapiens	100-109
1591007-7	1992	Furthermore, the suppressive effect of amiloride appeared to be at the level of mRNA for IL-8, TNF, IL-1 beta, and IL-6, whereas steady-state levels of beta-actin mRNA remained unaltered.	Amiloride	39-48	interleukin 6	Homo sapiens	115-119
1560205-3	1992	We found that conditions said to inhibit Ca2+ extrusion by Na+/Ca2+ exchange, namely low extracellular Na+ or the presence of certain amiloride analogs which block Na+/Ca2+ exchange, enhanced the cytolysin-mediated cytolysis of YAC-1 lymphoma cells.	Amiloride	134-143	perforin 1 (pore forming protein)	Mus musculus	196-205
1315776-10	1992	Third, the two amiloride derivatives 5-(N,N-hexamethylene) and 5-(N-ethyl-N-isopropyl)amiloride that specifically block the function of the Na+/H+ antiport also revert the protective effect of GM-CSF, IL-3, and TPA on MO7-E cells.	Amiloride	15-24	colony stimulating factor 2	Homo sapiens	193-199
1315776-10	1992	Third, the two amiloride derivatives 5-(N,N-hexamethylene) and 5-(N-ethyl-N-isopropyl)amiloride that specifically block the function of the Na+/H+ antiport also revert the protective effect of GM-CSF, IL-3, and TPA on MO7-E cells.	Amiloride	15-24	interleukin 3	Homo sapiens	201-205
1533769-8	1992	The inhibition of Na+/H+ exchange by the amiloride derivative, ethylisopropylamiloride, decreased the steady-state pHi of myocytes independently of the initial pHi values.	Amiloride	41-50	glucose-6-phosphate isomerase	Rattus norvegicus	115-118
1322994-4	1992	Readdition of external sodium resulted in a rapid pHi recovery, which was almost completely amiloride-sensitive in the absence of CO2/HCO3- but only slightly influenced by amiloride in its presence.	Amiloride	92-101	glucose-6-phosphate isomerase	Homo sapiens	50-53
1322994-4	1992	Readdition of external sodium resulted in a rapid pHi recovery, which was almost completely amiloride-sensitive in the absence of CO2/HCO3- but only slightly influenced by amiloride in its presence.	Amiloride	172-181	glucose-6-phosphate isomerase	Homo sapiens	50-53
1322994-7	1992	In HEPES-buffered solution the pHi recovery was almost completely mediated by Na+/H+ exchange, since it was blocked by amiloride (1 mmol/liter).	Amiloride	119-128	glucose-6-phosphate isomerase	Homo sapiens	31-34
1322994-8	1992	In contrast, a marked amiloride-insensitive pHi recovery was observed in CO2/HCO3(-)-buffered solution which was mediated by chloride-independent and chloride-dependent Na+ HCO3- cotransport.	Amiloride	22-31	glucose-6-phosphate isomerase	Homo sapiens	44-47
1322994-10	1992	Analysis of the sodium dependence of the pHi recovery after NH4Cl prepulse revealed Vmax = 0.57 pH units/min, Km = 39.7 mmol/liter extracellular sodium for the amiloride-sensitive component and Vmax = 0.19 pH units/min, Km = 14.3 mmol/liter extracellular sodium for the amiloride-insensitive component.	Amiloride	160-169	glucose-6-phosphate isomerase	Homo sapiens	41-44
1322994-10	1992	Analysis of the sodium dependence of the pHi recovery after NH4Cl prepulse revealed Vmax = 0.57 pH units/min, Km = 39.7 mmol/liter extracellular sodium for the amiloride-sensitive component and Vmax = 0.19 pH units/min, Km = 14.3 mmol/liter extracellular sodium for the amiloride-insensitive component.	Amiloride	270-279	glucose-6-phosphate isomerase	Homo sapiens	41-44
1627180-4	1992	Insulin-stimulated synthesis of the plasma membrane "signal" ATP in an amount of 1-10 nM is potentized by ionophores carbonyl cyanide p-trifluorometoxyphenylhydrazone and monensin and inhibited by amiloride and ouabain.	Amiloride	197-206	insulin	Homo sapiens	0-7
1560205-3	1992	We found that conditions said to inhibit Ca2+ extrusion by Na+/Ca2+ exchange, namely low extracellular Na+ or the presence of certain amiloride analogs which block Na+/Ca2+ exchange, enhanced the cytolysin-mediated cytolysis of YAC-1 lymphoma cells.	Amiloride	134-143	ADP-ribosyltransferase 1	Mus musculus	228-233
1560205-7	1992	The Na+/Ca2+ exchange system appeared to be more active in cytolysin-challenged cells: amiloride analogs, which inhibit Na+/Ca2+ exchange in other systems, acted synergistically with cytolysin to cause large increases in [Ca2+]i, but had little effect, if any, on their own.	Amiloride	87-96	perforin 1 (pore forming protein)	Mus musculus	59-68
1560205-7	1992	The Na+/Ca2+ exchange system appeared to be more active in cytolysin-challenged cells: amiloride analogs, which inhibit Na+/Ca2+ exchange in other systems, acted synergistically with cytolysin to cause large increases in [Ca2+]i, but had little effect, if any, on their own.	Amiloride	87-96	perforin 1 (pore forming protein)	Mus musculus	183-192
1560205-8	1992	5-(N-4-Chlorobenzyl)-2",4"-dimethylbenzamil, the amiloride analog which has the greatest specificity for the Na+/Ca2+ exchanger and which previously was found to be the most potent enhancer of cytolysin-mediated cytolysis, was the most potent enhancer of cytolysin-mediated increases in [Ca2+]i.	Amiloride	49-58	perforin 1 (pore forming protein)	Mus musculus	193-202
1560205-8	1992	5-(N-4-Chlorobenzyl)-2",4"-dimethylbenzamil, the amiloride analog which has the greatest specificity for the Na+/Ca2+ exchanger and which previously was found to be the most potent enhancer of cytolysin-mediated cytolysis, was the most potent enhancer of cytolysin-mediated increases in [Ca2+]i.	Amiloride	49-58	perforin 1 (pore forming protein)	Mus musculus	255-264
1316712-5	1992	In HCO3(-)-free media, pHi recovery following acid loading was blocked by amiloride (10(-4) M) and hexamethylene-amiloride (10(-6) M), demonstrating amiloride- and hexamethylene-amiloride-sensitive Na(+)-H+ exchange.	Amiloride	74-83	HCO3	Sus scrofa	3-7
1314493-4	1992	In addition, amiloride-insensitive pHi recovery was inhibited by bafilomycin A1, 10(-3) M N-ethylmaleimide, and 10(-4) M preactivated omeprazole but not by 10(-5) M vanadate, 10(-4) M SCH 28080, or removal of extracellular potassium.	Amiloride	13-22	glucose-6-phosphate isomerase	Rattus norvegicus	35-38
1614824-7	1992	Apical application of amiloride (1 mmol/l) reduced dome pH in both ET-1-treated and non-treated domes to essentially the same level, 7.25 +/- 0.03 (n = 19) and 7.23 +/- 0.03 (n = 17) respectively.	Amiloride	22-31	endothelin 1	Canis lupus familiaris	67-71
1316712-5	1992	In HCO3(-)-free media, pHi recovery following acid loading was blocked by amiloride (10(-4) M) and hexamethylene-amiloride (10(-6) M), demonstrating amiloride- and hexamethylene-amiloride-sensitive Na(+)-H+ exchange.	Amiloride	74-83	vasoactive intestinal peptide	Sus scrofa	23-26
1316712-5	1992	In HCO3(-)-free media, pHi recovery following acid loading was blocked by amiloride (10(-4) M) and hexamethylene-amiloride (10(-6) M), demonstrating amiloride- and hexamethylene-amiloride-sensitive Na(+)-H+ exchange.	Amiloride	113-122	HCO3	Sus scrofa	3-7
1316712-5	1992	In HCO3(-)-free media, pHi recovery following acid loading was blocked by amiloride (10(-4) M) and hexamethylene-amiloride (10(-6) M), demonstrating amiloride- and hexamethylene-amiloride-sensitive Na(+)-H+ exchange.	Amiloride	113-122	vasoactive intestinal peptide	Sus scrofa	23-26
1588302-9	1992	The rate of cellular NH4+ influx in IP-MTAL due to the apical Ba(2+)-sensitive NH4+ transport pathway was sensitive to reduction in cytosolic pH whether pHi was changed by acidifying the basolateral medium or by inhibition of the apical Na+:H+ exchanger with amiloride at a constant pHo of 7.4.	Amiloride	259-268	glucose-6-phosphate isomerase 1	Mus musculus	153-156
1550208-6	1992	In amiloride-treated HNE, the electrical pattern of the BK-induced response was identical, but the magnitude of the Ieq was reduced by 54% and the change in Ieq could be abolished by removal of bath Cl-.	Amiloride	3-12	kininogen 1	Homo sapiens	56-58
1550208-8	1992	We conclude that BK stimulates both Na+ absorption in untreated HNE and Cl- secretion in amiloride-treated HNE by activating a basolateral (K+) conductance.	Amiloride	89-98	kininogen 1	Homo sapiens	17-19
1311273-11	1992	If adequate serosal (or systemic) HCO3- is not available, a second-line Na(+)-dependent and amiloride-sensitive pHi-regulatory mechanism, presumably an Na+/H+ antiport, becomes the main regulator of pHi.	Amiloride	92-101	glucose-6-phosphate isomerase	Homo sapiens	112-115
1311273-11	1992	If adequate serosal (or systemic) HCO3- is not available, a second-line Na(+)-dependent and amiloride-sensitive pHi-regulatory mechanism, presumably an Na+/H+ antiport, becomes the main regulator of pHi.	Amiloride	92-101	glucose-6-phosphate isomerase	Homo sapiens	199-202
1354733-5	1992	Furthermore, the relaxing effect of THP or carbachol was inhibited by pretreatment with amiloride (10(-4)-3 x 10(-4) M), with ouabain (10(-4)-10(-3) M), or with K(+)-depletion.	Amiloride	88-97	uromodulin	Rattus norvegicus	36-39
1629906-6	1992	A similar pHi recovery was also stimulated by Li, Cs (both 72 mM), and Tl (10 mM), in the order Li greater than K greater than Cs greater than Tl (all in the presence of amiloride), and these alkalinizations were also blocked by 100 microM SCH28080.	Amiloride	170-179	glucose-6-phosphate isomerase	Oryctolagus cuniculus	10-13
1548835-8	1992	In contrast, the alkalization induced by AII was abolished by both amiloride and Na(+)-free medium.	Amiloride	67-76	angiotensinogen	Rattus norvegicus	41-44
1311525-2	1992	When the apical Na(+)-H+ antiporter was inhibited in the absence of AVP with removal of luminal Na+ plus addition of 0.5 mM amiloride, a small but significant increase in pHi was observed after luminal NH4Cl-induced acidification of MTAL cells to pHi less than 6.7.	Amiloride	124-133	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	16-35
1311525-2	1992	When the apical Na(+)-H+ antiporter was inhibited in the absence of AVP with removal of luminal Na+ plus addition of 0.5 mM amiloride, a small but significant increase in pHi was observed after luminal NH4Cl-induced acidification of MTAL cells to pHi less than 6.7.	Amiloride	124-133	glucose-6-phosphate isomerase 1	Mus musculus	171-174
1311525-2	1992	When the apical Na(+)-H+ antiporter was inhibited in the absence of AVP with removal of luminal Na+ plus addition of 0.5 mM amiloride, a small but significant increase in pHi was observed after luminal NH4Cl-induced acidification of MTAL cells to pHi less than 6.7.	Amiloride	124-133	glucose-6-phosphate isomerase 1	Mus musculus	247-250
1311525-6	1992	In the absence of AVP, addition of 0.5 mM amiloride to the luminal perfusate reduced steady-state pHi by 0.40 +/- 0.07 units, whereas exposure of the basolateral membrane to the same concentration of amiloride had no effect on pHi (delta pHi = 0.01 +/- 0.01 units).	Amiloride	42-51	glucose-6-phosphate isomerase 1	Mus musculus	98-101
1311525-6	1992	In the absence of AVP, addition of 0.5 mM amiloride to the luminal perfusate reduced steady-state pHi by 0.40 +/- 0.07 units, whereas exposure of the basolateral membrane to the same concentration of amiloride had no effect on pHi (delta pHi = 0.01 +/- 0.01 units).	Amiloride	42-51	glucose-6-phosphate isomerase 1	Mus musculus	227-230
1311525-6	1992	In the absence of AVP, addition of 0.5 mM amiloride to the luminal perfusate reduced steady-state pHi by 0.40 +/- 0.07 units, whereas exposure of the basolateral membrane to the same concentration of amiloride had no effect on pHi (delta pHi = 0.01 +/- 0.01 units).	Amiloride	42-51	glucose-6-phosphate isomerase 1	Mus musculus	227-230
1311525-7	1992	AVP reduced the magnitude of cell acidification on exposure of apical membranes to amiloride (delta pHi = 0.16 +/- 0.03) but increased the pHi response to basolateral amiloride (delta pHi = 0.09 +/- 0.00).	Amiloride	83-92	arginine vasopressin	Mus musculus	0-3
1311525-7	1992	AVP reduced the magnitude of cell acidification on exposure of apical membranes to amiloride (delta pHi = 0.16 +/- 0.03) but increased the pHi response to basolateral amiloride (delta pHi = 0.09 +/- 0.00).	Amiloride	167-176	arginine vasopressin	Mus musculus	0-3
1311525-7	1992	AVP reduced the magnitude of cell acidification on exposure of apical membranes to amiloride (delta pHi = 0.16 +/- 0.03) but increased the pHi response to basolateral amiloride (delta pHi = 0.09 +/- 0.00).	Amiloride	167-176	glucose-6-phosphate isomerase 1	Mus musculus	139-142
1311525-7	1992	AVP reduced the magnitude of cell acidification on exposure of apical membranes to amiloride (delta pHi = 0.16 +/- 0.03) but increased the pHi response to basolateral amiloride (delta pHi = 0.09 +/- 0.00).	Amiloride	167-176	glucose-6-phosphate isomerase 1	Mus musculus	139-142
1531920-3	1992	The subsequent recovery of pHi was unimpaired by the absence of extracellular K+, but was reduced in the presence of the Na+ antagonist amiloride (1 mmol/l), recovering by 0.11 +/- 0.003 units, compared with 0.27 +/- 0.02 units under amiloride-free conditions.	Amiloride	136-145	glucose-6-phosphate isomerase	Rattus norvegicus	27-30
1531920-3	1992	The subsequent recovery of pHi was unimpaired by the absence of extracellular K+, but was reduced in the presence of the Na+ antagonist amiloride (1 mmol/l), recovering by 0.11 +/- 0.003 units, compared with 0.27 +/- 0.02 units under amiloride-free conditions.	Amiloride	234-243	glucose-6-phosphate isomerase	Rattus norvegicus	27-30
1531920-4	1992	In the presence of the H(+)-dependent ATPase antagonist N,N"-dicyclohexylcarbodiimide (DCC), the pHi recovery observed in amiloride-containing, K(+)-free buffer was abolished.	Amiloride	122-131	glucose-6-phosphate isomerase	Rattus norvegicus	97-100
1548835-11	1992	These results indicate that AII stimulates cytoplasmic alkalization via an amiloride-sensitive Na+/H+ exchange system in cultured rat VSMCs, and that this AII-stimulated Na+/H+ exchange is mediated by Ca(2+)-dependent and protein kinase C-dependent mechanisms.	Amiloride	75-84	angiotensinogen	Rattus norvegicus	28-31
1548835-11	1992	These results indicate that AII stimulates cytoplasmic alkalization via an amiloride-sensitive Na+/H+ exchange system in cultured rat VSMCs, and that this AII-stimulated Na+/H+ exchange is mediated by Ca(2+)-dependent and protein kinase C-dependent mechanisms.	Amiloride	75-84	angiotensinogen	Rattus norvegicus	155-158
1310223-7	1992	For a given pHi, amiloride-inhibitable proton efflux rates during pHi recovery from an acid load were identical in resting and stimulated cells, suggesting that neither the transport capacity not the pHi set point of the parietal cell Na(+)-H+ exchanger is altered by cAMP-dependent stimulation of acid formation.	Amiloride	17-26	glucose-6-phosphate isomerase	Oryctolagus cuniculus	12-15
1310208-5	1992	2) In control cells, time courses of amiloride-induced pHi decreases (from 7.36 to 6.65) and of pHi recovery following amiloride removal (from 6.65 to 7.49) were curve fit by computer; rates of pHi decrease and recovery were calculated; and H delivery, net H efflux, and Na-H exchange were then calculated at the different pHi as above.	Amiloride	37-46	glucose-6-phosphate isomerase	Rattus norvegicus	55-58
1542430-5	1992	The DAP was blocked by amiloride (1 mM), which also decreased the preceding Ca2+ plateau.	Amiloride	23-32	death associated protein	Homo sapiens	4-7
1310223-7	1992	For a given pHi, amiloride-inhibitable proton efflux rates during pHi recovery from an acid load were identical in resting and stimulated cells, suggesting that neither the transport capacity not the pHi set point of the parietal cell Na(+)-H+ exchanger is altered by cAMP-dependent stimulation of acid formation.	Amiloride	17-26	glucose-6-phosphate isomerase	Oryctolagus cuniculus	66-69
1310208-5	1992	2) In control cells, time courses of amiloride-induced pHi decreases (from 7.36 to 6.65) and of pHi recovery following amiloride removal (from 6.65 to 7.49) were curve fit by computer; rates of pHi decrease and recovery were calculated; and H delivery, net H efflux, and Na-H exchange were then calculated at the different pHi as above.	Amiloride	119-128	glucose-6-phosphate isomerase	Rattus norvegicus	96-99
1310208-5	1992	2) In control cells, time courses of amiloride-induced pHi decreases (from 7.36 to 6.65) and of pHi recovery following amiloride removal (from 6.65 to 7.49) were curve fit by computer; rates of pHi decrease and recovery were calculated; and H delivery, net H efflux, and Na-H exchange were then calculated at the different pHi as above.	Amiloride	119-128	glucose-6-phosphate isomerase	Rattus norvegicus	96-99
1310208-5	1992	2) In control cells, time courses of amiloride-induced pHi decreases (from 7.36 to 6.65) and of pHi recovery following amiloride removal (from 6.65 to 7.49) were curve fit by computer; rates of pHi decrease and recovery were calculated; and H delivery, net H efflux, and Na-H exchange were then calculated at the different pHi as above.	Amiloride	119-128	glucose-6-phosphate isomerase	Rattus norvegicus	96-99
1310211-3	1992	Amiloride suppressed thrombin-stimulated PDGF production by human aortic EC without affecting either basal PDGF production or overall protein synthesis.	Amiloride	0-9	coagulation factor II, thrombin	Homo sapiens	21-29
1310223-7	1992	For a given pHi, amiloride-inhibitable proton efflux rates during pHi recovery from an acid load were identical in resting and stimulated cells, suggesting that neither the transport capacity not the pHi set point of the parietal cell Na(+)-H+ exchanger is altered by cAMP-dependent stimulation of acid formation.	Amiloride	17-26	glucose-6-phosphate isomerase	Oryctolagus cuniculus	66-69
1310229-9	1992	This effect was eliminated by luminal amiloride, suggesting an indirect effect of flow mediated by changes in pHi secondary to flow rate-dependent changes in apical membrane Na-H antiporter activity.	Amiloride	38-47	glucose-6-phosphate isomerase	Homo sapiens	110-113
1309326-8	1992	Amiloride (1 x 10(-5)-1 x 10(-3) M), which blocks the Na+/H+ exchange, decreased pHi and AVP- and forskolin-induced cAMP production in a dose-dependent manner.	Amiloride	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	81-84
1576669-5	1992	Amiloride protected the decrease of amidolytic activity of both factor Xa and thrombin by vanadate.	Amiloride	0-9	coagulation factor X	Homo sapiens	64-73
1576669-5	1992	Amiloride protected the decrease of amidolytic activity of both factor Xa and thrombin by vanadate.	Amiloride	0-9	coagulation factor II, thrombin	Homo sapiens	78-86
1309339-5	1992	However, amiloride significantly diminished the effect of melittin, an activator of PLA2 action.	Amiloride	9-18	phospholipase A2 group IB	Rattus norvegicus	84-88
1309326-8	1992	Amiloride (1 x 10(-5)-1 x 10(-3) M), which blocks the Na+/H+ exchange, decreased pHi and AVP- and forskolin-induced cAMP production in a dose-dependent manner.	Amiloride	0-9	arginine vasopressin	Rattus norvegicus	89-92
1309339-6	1992	LHRH release under PLA2 did not change when amiloride was added to the incubation medium.	Amiloride	44-53	gonadotropin releasing hormone 1	Rattus norvegicus	0-4
1560119-4	1992	Ion substitution and transepithelial flux experiments showed that 10 microM amiloride produced a decrease in the mucosal-to-serosal (M-S) and net Na flux, and that this effect on Isc was independent of Cl- and HCO3- replacement.	Amiloride	76-85	HCO3	Sus scrofa	210-214
12106376-7	1992	In cells that did not require bicarbonate for pHi recovery, amiloride (1 mM) inhibited pHi recovery.	Amiloride	60-69	glucose-6-phosphate isomerase	Rattus norvegicus	87-90
1560119-7	1992	The decrease in Isc due to 1 mM amiloride was dependent on both Cl- and HCO3-, and was attributed to reductions in the M-S and net Na+ fluxes as well as the M-S unidirectional Cl- flux.	Amiloride	32-41	HCO3	Sus scrofa	72-76
1728060-9	1992	When a mixture of 1.0 micrograms/ml nigericin, 0.5 mM amiloride, and 0.1 mM DIDS was present in the medium, the pHi rapidly decreased by about 0.3 and 0.4 pH units at pHe 7.2 and 6.6, respectively.	Amiloride	54-63	glucose-6-phosphate isomerase	Homo sapiens	112-115
1335564-5	1992	Amiloride (1 mM) caused an acidification of approximately 0.2 U within 2 min: replacement with normal Ringer allowed a return to normal pHi after an alkali overshoot.	Amiloride	0-9	glucose-6-phosphate isomerase	Bos taurus	136-139
1336615-4	1992	The lactoferrin-induced increase in Isc was not altered by amiloride, indomethacin, or propranolol but was abolished by diphenylamine-2-carboxylate or substitution of Cl with iodide in the medium.	Amiloride	59-68	lactotransferrin	Canis lupus familiaris	4-15
1662952-4	1991	Here we demonstrate that, very surprisingly, the addition of pentamidine (and to a lesser extent amiloride) to isolated hepatocytes results in an inhibition of the catalytic subunit of glucose-6-phosphatase.	Amiloride	97-106	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	185-206
1728060-3	1992	When the cells were treated with 0.5 mM amiloride at 37 degrees C, the pHi declined by 0.10-0.15 pH units at an extracellular pH (pHe) of both 7.2 and 6.6.	Amiloride	40-49	glucose-6-phosphate isomerase	Homo sapiens	71-74
1728060-6	1992	DIDS, however, enhanced the effects of amiloride in decreasing pHi and in increasing the thermoresponse of SCK cells, particularly at pHe 6.6.	Amiloride	39-48	glucose-6-phosphate isomerase	Homo sapiens	63-66
1662908-19	1991	Recovery of intracellular pH (pHi) was found to be strictly Na(+)-dependent and inhibited greater than or equal to 95% by 1 mM amiloride.	Amiloride	127-136	glucose-6-phosphate isomerase	Homo sapiens	30-33
1659220-5	1991	In the absence of HCO3-, reexposure to Na+ depolarized cells by 3 +/- 1 mV and caused an amiloride-inhibitable increase in pHi of 0.031 +/- 0.02 units/min.	Amiloride	89-98	glucose-6-phosphate isomerase	Rattus norvegicus	123-126
1659520-0	1991	Epidermal growth factor elevates intracellular pH in chicken granulosa cells by activating protein kinase C. Previous studies from our laboratory have demonstrated that epidermal growth factor (EGF), induces intracellular alkalinization in chicken granulosa cells by activating a sodium-dependent and amiloride-sensitive Na+/H+ antiporter.	Amiloride	301-310	epidermal growth factor	Gallus gallus	0-23
1659520-0	1991	Epidermal growth factor elevates intracellular pH in chicken granulosa cells by activating protein kinase C. Previous studies from our laboratory have demonstrated that epidermal growth factor (EGF), induces intracellular alkalinization in chicken granulosa cells by activating a sodium-dependent and amiloride-sensitive Na+/H+ antiporter.	Amiloride	301-310	epidermal growth factor	Gallus gallus	169-192
1659520-0	1991	Epidermal growth factor elevates intracellular pH in chicken granulosa cells by activating protein kinase C. Previous studies from our laboratory have demonstrated that epidermal growth factor (EGF), induces intracellular alkalinization in chicken granulosa cells by activating a sodium-dependent and amiloride-sensitive Na+/H+ antiporter.	Amiloride	301-310	epidermal growth factor	Gallus gallus	194-197
1659520-7	1991	Like EGF-induced cytosolic alkalinization, the increases in pHi in response to TPA or OAG were dependent on the presence of sodium concentration and were inhibited by amiloride, an inhibitor of the Na+/H+ antiporter.	Amiloride	167-176	epidermal growth factor	Gallus gallus	5-8
1658808-3	1991	8-Bromo cyclic GMP (1 microM) increased the amiloride-sensitive 22Na uptake in control from 1.26 +/- 0.13 to 1.54 +/- 0.12 nmol/mg/protein/10 sec, P less than 0.01, without altering the amiloride-insensitive component.	Amiloride	44-53	5'-nucleotidase, cytosolic II	Homo sapiens	15-18
1658808-3	1991	8-Bromo cyclic GMP (1 microM) increased the amiloride-sensitive 22Na uptake in control from 1.26 +/- 0.13 to 1.54 +/- 0.12 nmol/mg/protein/10 sec, P less than 0.01, without altering the amiloride-insensitive component.	Amiloride	186-195	5'-nucleotidase, cytosolic II	Homo sapiens	15-18
1722641-8	1991	This increase in pHi was not affected by amiloride but disappeared after inhibition of Na(+)-HCO3- cotransport by 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid or sodium-free conditions.	Amiloride	41-50	glucose-6-phosphate isomerase	Rattus norvegicus	17-20
1660595-4	1991	These agents decreased pHi in the absence of external Na+ or in the presence of amiloride.	Amiloride	80-89	glucose-6-phosphate isomerase	Rattus norvegicus	23-26
1919580-4	1991	The pHi returned toward the basal pH value after acidification within 5-10 min in the presence of Na+ or Li+, but the pHi stayed acidic when Na(+)-free buffers were used or in the presence of amiloride and its analogues.	Amiloride	192-201	glucose-6-phosphate isomerase	Bos taurus	118-121
1656780-9	1991	A Ca(2+)-calmodulin-dependent process activated the amiloride-sensitive basolateral Na(+)-H+ exchanger and inhibited the amiloride-resistant apical antiporter.	Amiloride	52-61	calmodulin-1	Sus scrofa	9-19
1822524-4	1991	About 96% of Cd2+ uptake was inhibited by DIDS (4,4"-diisothiocyanatostilbene-2,2"-disulphonic acid) with IC50 (concentration giving 50% of maximal inhibition) of 0.3 microM and by furosemide with IC50 of 500 microM and was resistant to ouabain and amiloride.	Amiloride	249-258	CD2 molecule	Homo sapiens	13-16
1917946-4	1991	We found that amiloride and ethyl isopropylamiloride, inhibitors of Na+/H+ exchange, blocked IFN-gamma-induced class II gene expression.	Amiloride	14-23	interferon gamma	Homo sapiens	93-102
1917946-5	1991	IFN-gamma stimulated Na+ influx, and this increased influx was inhibited by amiloride.	Amiloride	76-85	interferon gamma	Homo sapiens	0-9
1658182-1	1991	The amiloride-sensitive Na+/H+ antiporter in defolliculated oocytes of Xenopus laevis was characterized by measurements of 22Na+ influx and apparent H+ efflux.	Amiloride	4-13	solute carrier family 9 member 1 S homeolog	Xenopus laevis	24-41
1915841-6	1991	(4) Porcine urine PA activity is not affected by concentration of amiloride substantially suppressing human u-PA activity.	Amiloride	66-75	plasminogen activator, urokinase	Homo sapiens	108-112
1652938-6	1991	The inhibitory effect of ANF on adenylate cyclase was also dependent on the presence of guanine nucleotides and was attenuated by amiloride and pertussis toxin.	Amiloride	130-139	natriuretic peptide A	Rattus norvegicus	25-28
1649743-8	1991	The EGF-induced pHi change was also inhibited by amiloride, dimethyl amiloride, and ethylisopropyl amiloride, inhibitors of the Na+/H+ antiporter.	Amiloride	49-58	epidermal growth factor	Gallus gallus	4-7
1651331-3	1991	This pHi increase was Na(+)-dependent and was inhibited by 5,N-disubstituted analogs of amiloride, indicating mediation by the Na+/H+ antiport.	Amiloride	88-97	glucose-6-phosphate isomerase	Homo sapiens	5-8
1664334-12	1991	Furthermore, treatment with amiloride (100 microM), a blocker of the Na+/Ca2+ exchanger, did not inhibit the pH-induced changes in [Ca2+]i.	Amiloride	28-37	solute carrier family 8 member A1	Homo sapiens	69-87
1914252-8	1991	Furthermore, amiloride and ethylisopropyl-amiloride, inhibitors of Na+/H+ exchange, only partially blocked c-fos induction by serum.	Amiloride	13-22	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	107-112
1647205-1	1991	We have found that thrombin-induced activation of protein kinase C (PKC) in platelets, measured by phosphorylation of the 47 kDa protein, is synergistically enhanced by the amiloride analogue ethylisopropylamiloride (EIA), a specific inhibitor of Na+/H+ exchange.	Amiloride	173-182	coagulation factor II, thrombin	Homo sapiens	19-27
1647984-1	1991	alpha-Thrombin, phorbol esters (PMA) and 1,2-diacylglycerol (DAG), three activators of the amiloride-sensitive Na+/H+ exchange in human platelets, rapidly increase the intracellular pH and the level of phosphorylation of the Na+/H+ exchange protein (NHE1).	Amiloride	91-100	solute carrier family 9 member A1	Homo sapiens	250-254
1654419-23	1991	The low-threshold Ca2+ current in immature cells was blocked in a reversible and dose-dependent manner by amiloride (100-250 microM).	Amiloride	106-115	carbonic anhydrase 2	Rattus norvegicus	18-21
2058696-4	1991	pHi recovered in the presence of Na+ with an initial rate (dpHi/dt) of 0.15 min-1, which was reduced by 67% when Na+ was replaced by choline, unaffected by substitution of gluconate for Cl-, reduced 40% in the presence of 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS, 500 microM), and unchanged by amiloride (1 mM).	Amiloride	308-317	glucose-6-phosphate isomerase	Homo sapiens	0-3
1646047-9	1991	The sodium channel blocker amiloride prevented the GM-CSF-induced change in pH, but did not affect the stimulation of c-myc transcription by GM-CSF.	Amiloride	27-36	colony stimulating factor 2	Homo sapiens	51-57
2058732-6	1991	Addition of 1 mM amiloride completely abolished the GH-accelerated acid secretion and greater than 70% of the basal net acid secretion rate.	Amiloride	17-26	gonadotropin releasing hormone receptor	Rattus norvegicus	52-54
1645539-2	1991	Amiloride decreased the insulin response on  3-0-methylglucose transport, IGF-II- and insulin binding in both intact and energy depleted cells.	Amiloride	0-9	insulin-like growth factor 2	Rattus norvegicus	74-80
2058732-7	1991	Furthermore, GH-enhanced volume absorption was also abolished by amiloride, although neither NaCl nor glutamine absorption was affected.	Amiloride	65-74	gonadotropin releasing hormone receptor	Rattus norvegicus	13-15
1714010-4	1991	However, amiloride has multiple pharmacologic effects, including inhibition of the slow inward calcium current (ICa), inhibition of the sodium-calcium and sodium-hydronium ion exchangers, acidification of intracellular pH resulting in partial inhibition of the inwardly rectifying potassium current (IK1), and increase in serum potassium and magnesium.	Amiloride	9-18	potassium calcium-activated channel subfamily N member 4	Homo sapiens	300-303
1714010-12	1991	From these studies we conclude that the antiarrhythmic activity of amiloride relates to (a) selective blockade of IK1 in the border zone and/or (b) combined inhibition of sodium-calcium and sodium-hydronium ion exchangers.	Amiloride	67-76	potassium calcium-activated channel subfamily N member 4	Homo sapiens	114-117
1652031-7	1991	However, urokinase and plasmin (both serine proteases found in mammalian urine) were found to cause an irreversible loss of amiloride-sensitive current, a variable change in the leak current as well as the appearance of a third conductance which was unstable in the apical membrane and appears to partition between the apical membrane and the mucosal solution.	Amiloride	124-133	plasminogen	Homo sapiens	23-30
2035650-6	1991	pHi of PC and IC significantly increased by bath Cl- removal in the absence of Na+ and decreased by bath Na+ removal in the absence of Cl- but with amiloride.	Amiloride	148-157	glucose-6-phosphate isomerase	Oryctolagus cuniculus	0-3
1909616-9	1991	The observation that leading edge activity post-burn, in correlation with the formation of secondary defects, continues to be inhibitable by amiloride but not by antibodies to tPA suggests that uPA remains abnormally on the leading edge, and that sustained uPA activity in that location results in inappropriate degradation of subepithelial fibrin/Fn to result in a defect.	Amiloride	141-150	urokinase-type plasminogen activator	Oryctolagus cuniculus	194-197
1909616-9	1991	The observation that leading edge activity post-burn, in correlation with the formation of secondary defects, continues to be inhibitable by amiloride but not by antibodies to tPA suggests that uPA remains abnormally on the leading edge, and that sustained uPA activity in that location results in inappropriate degradation of subepithelial fibrin/Fn to result in a defect.	Amiloride	141-150	urokinase-type plasminogen activator	Oryctolagus cuniculus	257-260
1914146-6	1991	Recovery of pHi after NH4Cl prepulse was markedly inhibited in low-Na+ and in amiloride-containing HEPES HBSS.	Amiloride	78-87	glucose-6-phosphate isomerase 1	Mus musculus	12-15
1850271-4	1991	Ferric lactoferrin also stimulates NADH oxidase activity in isolated rat liver plasma membranes and stimulates amiloride sensitive proton release from K562 cells.	Amiloride	111-120	lactotransferrin	Rattus norvegicus	7-18
1647438-4	1991	When sodium transport was blocked by amiloride, the H+ permeability of the apical membranes of principal cells was negligible but increased dramatically after treatment with antidiuretic hormone (ADH).	Amiloride	37-46	arginine vasopressin	Homo sapiens	174-194
1652778-0	1991	Amiloride differentially modulates ANP binding in human thyroid cells and bovine endothelial cells.	Amiloride	0-9	natriuretic peptide A	Homo sapiens	35-38
1652778-1	1991	The diuretic and sodium channel inhibitor, amiloride, has been shown to increase atrial natriuretic peptide (ANP) binding several fold in certain cell types, but in other tissues it causes only marginal increases in specific ANP binding.	Amiloride	43-52	natriuretic peptide A	Homo sapiens	81-107
1649128-2	1991	Here, we demonstrate that amiloride neither inhibits the capability of IFN-gamma to activate the mononuclear phagocyte respiratory burst nor influences IFN-gamma induction of steady-state mRNA levels for 2 components of the superoxide anion-generating enzyme system.	Amiloride	26-35	interferon gamma	Homo sapiens	152-161
1649128-3	1991	On the contrary, we show that IFN-gamma-enhanced expression of the HLA-DR alpha gene is significantly inhibited by amiloride These data indicate that Na+/H+ antiporter stimulation by IFN-gamma is not involved in the mechanism of activation of macrophage oxidative metabolism.	Amiloride	115-124	interferon gamma	Homo sapiens	30-39
1649128-3	1991	On the contrary, we show that IFN-gamma-enhanced expression of the HLA-DR alpha gene is significantly inhibited by amiloride These data indicate that Na+/H+ antiporter stimulation by IFN-gamma is not involved in the mechanism of activation of macrophage oxidative metabolism.	Amiloride	115-124	major histocompatibility complex, class II, DR alpha	Homo sapiens	67-79
1652778-1	1991	The diuretic and sodium channel inhibitor, amiloride, has been shown to increase atrial natriuretic peptide (ANP) binding several fold in certain cell types, but in other tissues it causes only marginal increases in specific ANP binding.	Amiloride	43-52	natriuretic peptide A	Homo sapiens	109-112
1652778-1	1991	The diuretic and sodium channel inhibitor, amiloride, has been shown to increase atrial natriuretic peptide (ANP) binding several fold in certain cell types, but in other tissues it causes only marginal increases in specific ANP binding.	Amiloride	43-52	natriuretic peptide A	Homo sapiens	225-228
1652778-2	1991	In the present report we compare the effects of amiloride on ANP binding in bovine endothelial cells and human thyroid-derived cells, two cell types which differ in their predominant ANP receptor subtype.	Amiloride	48-57	natriuretic peptide A	Bos taurus	61-64
1652778-3	1991	We found that amiloride (10(-3) M) increased specific [125I]ANP binding to 750% above control in endothelial cells, but among several thyroid cultures tested the maximal increase in ANP binding with amiloride was only 23% above control.	Amiloride	14-23	natriuretic peptide A	Homo sapiens	60-63
1652778-3	1991	We found that amiloride (10(-3) M) increased specific [125I]ANP binding to 750% above control in endothelial cells, but among several thyroid cultures tested the maximal increase in ANP binding with amiloride was only 23% above control.	Amiloride	199-208	natriuretic peptide A	Homo sapiens	182-185
1652778-4	1991	Moreover, most of the thyroid cultures showed decreased ANP binding in the presence of amiloride.	Amiloride	87-96	natriuretic peptide A	Homo sapiens	56-59
1652778-5	1991	The increased ANP binding in endothelial cells exposed to amiloride is best explained by an increased affinity of the receptor for its ligand since the drug lowered the Kd of ANP binding from 0.73 nM to 0.16 nM without affecting the receptor binding capacity.	Amiloride	58-67	natriuretic peptide A	Homo sapiens	14-17
1652778-5	1991	The increased ANP binding in endothelial cells exposed to amiloride is best explained by an increased affinity of the receptor for its ligand since the drug lowered the Kd of ANP binding from 0.73 nM to 0.16 nM without affecting the receptor binding capacity.	Amiloride	58-67	natriuretic peptide A	Homo sapiens	175-178
1652778-6	1991	The degree of amiloride enhancement of ANP binding in endothelial cells is increased with time in culture (200% above control at 5 days, 750% above at 30 days) suggesting the increase of an amiloride-sensitive receptor relative to an amiloride-insensitive receptor.	Amiloride	14-23	natriuretic peptide A	Homo sapiens	39-42
1652778-7	1991	The fact that the amiloride-induced decrease in ANP binding in thyroid cells was not exacerbated by pre-incubation with amiloride suggested that the observed amiloride effect was not due to increased receptor internalization with the drug.	Amiloride	18-27	natriuretic peptide A	Homo sapiens	48-51
1652778-8	1991	These results support a hypothesis that ANP receptor subtypes associated with separate signal transduction mechanisms might be modulated in an opposite manner by the binding of amiloride.	Amiloride	177-186	natriuretic peptide A	Homo sapiens	40-43
1647438-4	1991	When sodium transport was blocked by amiloride, the H+ permeability of the apical membranes of principal cells was negligible but increased dramatically after treatment with antidiuretic hormone (ADH).	Amiloride	37-46	arginine vasopressin	Homo sapiens	196-199
1850091-0	1991	Monovalent cation and amiloride analog modulation of adrenergic ligand binding to the unglycosylated alpha 2B-adrenergic receptor subtype.	Amiloride	22-31	adrenergic receptor, alpha 2b	Mus musculus	101-129
1850091-1	1991	The unglycosylated alpha 2B subtype of the alpha 2-adrenergic receptor found in NG-108-15 cells possesses allosteric regulation of adrenergic ligand binding by monovalent cations and 5-amino-substituted amiloride analogs.	Amiloride	203-212	adrenergic receptor, alpha 2b	Mus musculus	19-27
1850091-3	1991	The observation that amiloride analogs as well as monovalent cations can modulate adrenergic ligand binding to the nonglycosylated alpha 2B subtype indicates that charge shielding due to carbohydrate moieties does not play a role in this allosteric modulation but, rather, these regulatory effects result from interactions of cations and amiloride analogs with the protein moiety of the receptor.	Amiloride	21-30	adrenergic receptor, alpha 2b	Mus musculus	131-139
1850091-4	1991	Furthermore, the observation that both alpha 2A and alpha 2B receptor subtypes are modulated by amiloride analogs suggests that structural domains that are conserved between the two are likely to be involved in this allosteric modulation.	Amiloride	96-105	adrenergic receptor, alpha 2a	Mus musculus	39-47
1850091-4	1991	Furthermore, the observation that both alpha 2A and alpha 2B receptor subtypes are modulated by amiloride analogs suggests that structural domains that are conserved between the two are likely to be involved in this allosteric modulation.	Amiloride	96-105	adrenergic receptor, alpha 2b	Mus musculus	52-60
1847362-2	1991	We investigated the possible relationship between changes in the thermal response of SCK mouse mammary tumor cells in vitro and changes in intracellular pH (pHi) due to amiloride in the present study.	Amiloride	169-178	glucose-6-phosphate isomerase 1	Mus musculus	157-160
1850247-1	1991	Endothelin-1-induced contractions of guinea pig tracheal and bronchial strips were dose-dependently attenuated by the amiloride analogues 5-(N-ethyl-N-isopropyl)amiloride (EIPA, 1-10 microM) and 5-(N,N-hexamethylene)amiloride (HMA, 1-10 microM).	Amiloride	118-127	endothelin-1	Cavia porcellus	0-12
1847362-6	1991	The presence of 0.5 mM amiloride significantly reduced pHi in both pH 7.2 and 6.6 medium.	Amiloride	23-32	glucose-6-phosphate isomerase 1	Mus musculus	55-58
1847362-8	1991	The combined effect of heat and amiloride in reducing the pHi of SCK cells was additive.	Amiloride	32-41	glucose-6-phosphate isomerase 1	Mus musculus	58-61
1847362-9	1991	These results suggest that the effects of amiloride on the thermal response of SCK cells might be mediated in part by a decrease in pHi.	Amiloride	42-51	glucose-6-phosphate isomerase 1	Mus musculus	132-135
1847131-0	1991	Regulation of intracellular pH in cultured hippocampal neurons by an amiloride-insensitive Na+/H+ exchanger.	Amiloride	69-78	glucose-6-phosphate isomerase	Rattus norvegicus	28-30
2003583-9	1991	In the absence of a demonstrable H+ conductance, it is concluded that amiloride-induced acidification and K(+)-induced pHi changes are via a carrier-mediated K(+)-H+ exchanger.	Amiloride	70-79	glucose-6-phosphate isomerase	Oryctolagus cuniculus	119-122
1705099-9	1991	In addition, both antibodies are sensitive to changes in the C-6 halo group on amiloride.	Amiloride	79-88	complement C6	Homo sapiens	61-64
1846315-8	1991	High concentrations of amiloride, 1.0 mM for 1 h in combination with low Na+ concentrations, caused a strong pHi decrease in glioma cells but only a slight decrease in the colon carcinoma cells.	Amiloride	23-32	glucose-6-phosphate isomerase	Homo sapiens	109-112
1996668-4	1991	These actions of EGF were prevented by pretreatment with 50 microM luminal amiloride.	Amiloride	75-84	pro-epidermal growth factor	Oryctolagus cuniculus	17-20
1996668-7	1991	From these results, we conclude that EGF acts on the CD cell at the basolateral border and inhibits mainly the amiloride-sensitive Na+ conductance in the apical membrane.	Amiloride	111-120	pro-epidermal growth factor	Oryctolagus cuniculus	37-40
1848330-8	1991	In acid loaded proximal tubules VIP (10(-6) M) inhibited total and amiloride-sensitive 22Na uptake by 35 and 75%, respectively, as compared to control.	Amiloride	67-76	VIP peptides	Oryctolagus cuniculus	32-35
1999477-2	1991	PMA or thrombin caused a cytoplasmic alkalinization that required extracellular sodium and was sensitive to 1 mM amiloride, suggesting that the rise in pH was mediated by the Na+/H+ exchanger.	Amiloride	113-122	coagulation factor II, thrombin	Homo sapiens	7-15
1987808-4	1991	pHi recovery was inhibited by amiloride.	Amiloride	30-39	glucose-6-phosphate isomerase	Rattus norvegicus	0-3
1846528-11	1991	The protein kinase inhibitors H-8, staurosporine, K252a and amiloride inhibited IL-1 beta- and TNF-stimulated phospholipase A2 secretion.	Amiloride	60-69	interleukin 1 beta	Rattus norvegicus	80-89
1845855-5	1991	Amiloride (10(-4)M) prevented the increase in pHi in response to endothelin and reduced the inotropic response by 45%, although the inotropic effect could be readily restored by subsequent NH4Cl-induced alkalinization.	Amiloride	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	46-49
1846528-11	1991	The protein kinase inhibitors H-8, staurosporine, K252a and amiloride inhibited IL-1 beta- and TNF-stimulated phospholipase A2 secretion.	Amiloride	60-69	tumor necrosis factor	Rattus norvegicus	95-98
1846528-11	1991	The protein kinase inhibitors H-8, staurosporine, K252a and amiloride inhibited IL-1 beta- and TNF-stimulated phospholipase A2 secretion.	Amiloride	60-69	phospholipase A2 group IB	Rattus norvegicus	110-126
1959337-4	1991	LDL and Apo-B also caused transient acidification followed by Na(+)-dependent and amiloride-sensitive alkalization of the cells due to stimulation of a Na+/H+ exchanger.	Amiloride	82-91	apolipoprotein B	Rattus norvegicus	8-13
1725340-6	1991	TGF-beta-stimulated ET-1 and big ET-1 secretion in the basolateral bath were inhibited when 10 microM amiloride (Na+ channel blocker) or 1 microM ouabain (Na+, K(+)-ATPase inhibitor) was added for 3 h. Polarized secretion of ET-1 and big ET-1 was not affected.	Amiloride	102-111	endothelin 1	Canis lupus familiaris	20-24
1846099-3	1991	The action of ionomycin on pHi was abolished by preincubating the cells with 100 microM amiloride or by replacing extracellular Na+ with choline+, indicating that the change in pHi was probably due to activation of Na+/H+ exchange.	Amiloride	88-97	glucose-6-phosphate isomerase	Rattus norvegicus	27-30
1725340-6	1991	TGF-beta-stimulated ET-1 and big ET-1 secretion in the basolateral bath were inhibited when 10 microM amiloride (Na+ channel blocker) or 1 microM ouabain (Na+, K(+)-ATPase inhibitor) was added for 3 h. Polarized secretion of ET-1 and big ET-1 was not affected.	Amiloride	102-111	endothelin 1	Canis lupus familiaris	33-37
1725340-6	1991	TGF-beta-stimulated ET-1 and big ET-1 secretion in the basolateral bath were inhibited when 10 microM amiloride (Na+ channel blocker) or 1 microM ouabain (Na+, K(+)-ATPase inhibitor) was added for 3 h. Polarized secretion of ET-1 and big ET-1 was not affected.	Amiloride	102-111	endothelin 1	Canis lupus familiaris	33-37
1725340-6	1991	TGF-beta-stimulated ET-1 and big ET-1 secretion in the basolateral bath were inhibited when 10 microM amiloride (Na+ channel blocker) or 1 microM ouabain (Na+, K(+)-ATPase inhibitor) was added for 3 h. Polarized secretion of ET-1 and big ET-1 was not affected.	Amiloride	102-111	endothelin 1	Canis lupus familiaris	33-37
1965732-6	1990	Amiloride partially inhibited the response induced by endothelin-1 indicating that Na+ channels and/or Na+/H+ exchange are probably involved in its action.	Amiloride	0-9	endothelin-1	Cavia porcellus	54-66
1658090-5	1991	Amiloride (100 mumol.l-1) inhibited only about 60% of INa.	Amiloride	0-9	internexin neuronal intermediate filament protein alpha	Gallus gallus	54-57
1661335-1	1991	Amiloride and its analogues affect radioligand binding to the adenosine-A1 receptor.	Amiloride	0-9	adenosine A1 receptor	Homo sapiens	62-83
1964210-7	1990	This Na(+)-induced increase in pHi was almost completely inhibited by 0.5 mmol/l amiloride and was associated with a rapid, amiloride-sensitive increase in aNai.	Amiloride	81-90	glucose-6-phosphate isomerase 1	Mus musculus	31-34
1964210-7	1990	This Na(+)-induced increase in pHi was almost completely inhibited by 0.5 mmol/l amiloride and was associated with a rapid, amiloride-sensitive increase in aNai.	Amiloride	124-133	glucose-6-phosphate isomerase 1	Mus musculus	31-34
1966525-3	1990	When cells were acidified by ammonium withdrawal, the initial pHi recovery rate was 0.33 +/- 0.02 pH unit/min; replacement of extracellular Na+ (130 mM) with N-methyl-D-glucamine+ reduced the pHi recovery rate to 0.08 +/- 0.02 pH unit/min, while addition of 0.1 mM amiloride in the presence of extracellular Na+ reduced the rate of pHi recovery to 0.02 +/- 0.02 pH unit/min.	Amiloride	265-274	glucose-6-phosphate isomerase	Oryctolagus cuniculus	62-65
1966525-3	1990	When cells were acidified by ammonium withdrawal, the initial pHi recovery rate was 0.33 +/- 0.02 pH unit/min; replacement of extracellular Na+ (130 mM) with N-methyl-D-glucamine+ reduced the pHi recovery rate to 0.08 +/- 0.02 pH unit/min, while addition of 0.1 mM amiloride in the presence of extracellular Na+ reduced the rate of pHi recovery to 0.02 +/- 0.02 pH unit/min.	Amiloride	265-274	glucose-6-phosphate isomerase	Oryctolagus cuniculus	192-195
1966525-3	1990	When cells were acidified by ammonium withdrawal, the initial pHi recovery rate was 0.33 +/- 0.02 pH unit/min; replacement of extracellular Na+ (130 mM) with N-methyl-D-glucamine+ reduced the pHi recovery rate to 0.08 +/- 0.02 pH unit/min, while addition of 0.1 mM amiloride in the presence of extracellular Na+ reduced the rate of pHi recovery to 0.02 +/- 0.02 pH unit/min.	Amiloride	265-274	glucose-6-phosphate isomerase	Oryctolagus cuniculus	192-195
2402228-8	1990	On the other hand, 5-[N-methyl-N-guanidinocarbonylmethyl]amiloride (MGCMA) (100-300 microM), which lacks inhibitory properties on the Na(+)-Ca2+ exchanger but behaves as an inhibitor of the Na(+)-H+ antiporter, failed to modify basal [3H]DA release from TIDA neurons.	Amiloride	57-66	solute carrier family 8 member A1	Homo sapiens	134-154
2173584-5	1990	The effect was abolished by replacing extracellular Na+ with choline+, and by pretreatment of the cells with amiloride, indicating that the change in pHi probably was dependent on activation of Na+/H+ exchange.	Amiloride	109-118	glucose-6-phosphate isomerase	Rattus norvegicus	150-153
2145772-1	1990	We have previously shown that cytoplasmic pH (pHi) recovery in pulmonary macrophages, under nominally HCO3(-)-free conditions, after acute intracellular acidification is Na+ and amiloride insensitive and is blocked by nonspecific proton adenosinetriphosphatase (ATPase) inhibitors N-ethyl-maleimide and N,N"-dicyclohexylcarbodiimide [Am.	Amiloride	178-187	glucose-6-phosphate isomerase	Homo sapiens	46-49
1699514-1	1990	Amiloride is an inhibitor of urokinase-type plasminogen activator, and might therefore have an inhibitory effect on neovascularization.	Amiloride	0-9	urokinase-type plasminogen activator	Oryctolagus cuniculus	29-65
2169196-5	1990	In CO2-HCO3(-)-containing media, amiloride-sensitive Na(+)-H+ exchange mediated 85% of acid extrusion at a pHi of 6.48, but the DIDS-sensitive acid extrusion mechanism (NA(+)-dependent Cl(-)-HCO3- exchange) was the dominant acid extrusion mechanism at a pHi of 6.94.	Amiloride	33-42	glucose-6-phosphate isomerase	Homo sapiens	107-110
2169196-5	1990	In CO2-HCO3(-)-containing media, amiloride-sensitive Na(+)-H+ exchange mediated 85% of acid extrusion at a pHi of 6.48, but the DIDS-sensitive acid extrusion mechanism (NA(+)-dependent Cl(-)-HCO3- exchange) was the dominant acid extrusion mechanism at a pHi of 6.94.	Amiloride	33-42	glucose-6-phosphate isomerase	Homo sapiens	254-257
2169196-7	1990	Both amiloride- and DIDS-sensitive processes regulated steady-state pHi in CO2-HCO3-.	Amiloride	5-14	glucose-6-phosphate isomerase	Homo sapiens	68-71
2168329-16	1990	These studies indicate that nucleated esophageal cells obtained from rabbits possess an amiloride-sensitive Na+,H+ antiport that functions to regulate basal pHi and responds to intracellular acidification.	Amiloride	88-97	glucose-6-phosphate isomerase	Oryctolagus cuniculus	157-160
2277799-4	1990	Angiotensin II of 10(-5) M exerted to a lesser extent, a similar significant stimulatory effect on Kc of 86Rb washout, which effect was inhibited with application of amiloride.	Amiloride	166-175	angiotensinogen	Homo sapiens	0-14
2117398-6	1990	In absence of HCO3-, agents other than BK and IL-1 produced a biphasic pHi response characterized by a transient acidification followed by a prolonged alkalinization that was both Na(+)-dependent and amiloride-sensitive.	Amiloride	200-209	glucose-6-phosphate isomerase	Rattus norvegicus	71-74
2369117-0	1990	Extracellular ATP stimulates an amiloride-sensitive sodium influx in human lymphocytes.	Amiloride	32-41	ATPase phospholipid transporting 8A2	Homo sapiens	14-17
1974737-1	1990	To determine a renal tubular mechanism for the natriuretic effect of dopamine (DA) and DA-1 agonists, we measured Na(+)-H+ exchange activity (amiloride sensitive) in rat renal cortical brush-border membrane vesicles (BBMV).	Amiloride	142-151	RT1 class II, locus Da	Rattus norvegicus	87-91
2161642-12	1990	These findings suggest that vanadate increases the LPL activity through mechanisms of action involving amiloride- and monensin-sensitive pathways dependent on energy.	Amiloride	103-112	lipoprotein lipase	Rattus norvegicus	51-54
2143376-3	1990	Unlike what is observed in neutrophils, induction by IFN-gamma of macrophage Fc gamma R-I mRNA was significantly depressed by the Na+/H+ antiporter inhibitor amiloride.	Amiloride	158-167	interferon gamma	Homo sapiens	53-62
2143376-3	1990	Unlike what is observed in neutrophils, induction by IFN-gamma of macrophage Fc gamma R-I mRNA was significantly depressed by the Na+/H+ antiporter inhibitor amiloride.	Amiloride	158-167	Fc gamma receptor Ia	Homo sapiens	77-89
2369117-6	1990	The amiloride analogs 5-(N-ethyl-N-isopropyl) amiloride and 5-(N,N-hexamethylene) amiloride, which are potent inhibitors of Na(+)-H+ countertransport, abolished 72-95% of the ATP-stimulated 22Na+ influx.	Amiloride	4-13	ATPase phospholipid transporting 8A2	Homo sapiens	175-178
2369117-11	1990	These data suggest that ATP acts cooperatively to induce the formation of membrane channels which allow increased Na+ influx by a pathway which is partially inhibited by amiloride and its analogs.	Amiloride	170-179	ATPase phospholipid transporting 8A2	Homo sapiens	24-27
2382444-9	1990	Na-free solution led to a pHi decrease to 7.39 +/- 0.04 after 16 min, pHi was also lowered by 8 minute incubation of cells with 1 mM amiloride (7.40 +/- 0.02).	Amiloride	133-142	glucose-6-phosphate isomerase	Homo sapiens	26-29
2382444-9	1990	Na-free solution led to a pHi decrease to 7.39 +/- 0.04 after 16 min, pHi was also lowered by 8 minute incubation of cells with 1 mM amiloride (7.40 +/- 0.02).	Amiloride	133-142	glucose-6-phosphate isomerase	Homo sapiens	70-73
2382444-11	1990	Recovery from an acute acid load, induced by NH4 prepulse or switching from HEPES- to bicarbonate-buffered solution, was Na dependent, Cl independent, reversible and only partially blocked by 1 mM amiloride - pHi slowly recovered from 6.83 +/- 0.03 to 7.00 +/- 0.06 in 8 minutes.	Amiloride	197-206	glucose-6-phosphate isomerase	Homo sapiens	209-212
2382444-12	1990	In the presence of amiloride and 200 microns H2DIDS (dihydro-4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid) pHi recovery was completely inhibited for 8 minutes.	Amiloride	19-28	glucose-6-phosphate isomerase	Homo sapiens	113-116
2159405-4	1990	Inhibition of Na(+)-H+ exchange by amiloride antagonized the action of EGF.	Amiloride	35-44	epidermal growth factor	Gallus gallus	71-74
2356751-3	1990	The experiments presented were carried out on isolated frog skin bathed in Cl- or NO3- Ringer"s solution, where the active transepithelial Na+ uptake via the granular cells was blocked by amiloride.	Amiloride	188-197	NBL1, DAN family BMP antagonist	Homo sapiens	82-85
2213591-12	1990	In bicarbonate-buffered solution pHi recovery after an acid load was also completely blocked by addition of 1.5 mM-amiloride indicating the absence of a bicarbonate-dependent acid extrusion mechanism.	Amiloride	114-124	glucose-6-phosphate isomerase	Rattus norvegicus	33-36
2359404-0	1990	Amiloride analogs induce the phosphorylation of elongation factor-2 in vascular endothelial cells.	Amiloride	0-9	eukaryotic translation elongation factor 2	Bos taurus	48-67
2359404-5	1990	Because phosphorylation decreases the activity of elongation factor-2, our observation might explain why amiloride analogs inhibit protein synthesis.	Amiloride	105-114	eukaryotic translation elongation factor 2	Bos taurus	50-69
2158745-9	1990	Under steady-state conditions in the presence of 25 mM HCO3(-)-5% CO2 at pHo 7.4, pHi was 7.40 +/- 0.02 and reversibly decreased to 7.23 +/- 0.01 on removal of Na+ (in the presence of amiloride) from the bathing medium, indicating that the Cl(-)-base exchanger is operative under basal conditions and functions as a base extruder.	Amiloride	184-193	glucose-6-phosphate isomerase	Macaca fascicularis	82-85
2109681-8	1990	PA activity was inhibited by placental urokinase (uPA) inhibitor and amiloride, which indicated that it was a uPA, but the secreted form required tissue-type PA stimulator (fibrin peptides) or denatured microsomes for full activity.	Amiloride	69-78	plasminogen activator, urokinase	Bos taurus	110-113
2332047-0	1990	The interaction of amiloride with acetylcholinesterase and butyrylcholinesterase.	Amiloride	19-28	acetylcholinesterase (Cartwright blood group)	Homo sapiens	34-54
2332047-0	1990	The interaction of amiloride with acetylcholinesterase and butyrylcholinesterase.	Amiloride	19-28	butyrylcholinesterase	Homo sapiens	59-80
2332047-1	1990	The diuretic drug amiloride was found to be a powerful inhibitor of the reaction of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with their specific choline ester substrates.	Amiloride	18-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	84-104
2332047-1	1990	The diuretic drug amiloride was found to be a powerful inhibitor of the reaction of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with their specific choline ester substrates.	Amiloride	18-27	acetylcholinesterase (Cartwright blood group)	Homo sapiens	106-110
2332047-1	1990	The diuretic drug amiloride was found to be a powerful inhibitor of the reaction of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with their specific choline ester substrates.	Amiloride	18-27	butyrylcholinesterase	Homo sapiens	116-137
2332047-1	1990	The diuretic drug amiloride was found to be a powerful inhibitor of the reaction of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with their specific choline ester substrates.	Amiloride	18-27	butyrylcholinesterase	Homo sapiens	139-143
2332047-3	1990	On the other hand, when added to a mixture of cholinesterase (AChE and BChE) and neutral substrates, amiloride, in some cases, enhanced the reaction rate.	Amiloride	101-110	butyrylcholinesterase	Homo sapiens	46-60
2332047-3	1990	On the other hand, when added to a mixture of cholinesterase (AChE and BChE) and neutral substrates, amiloride, in some cases, enhanced the reaction rate.	Amiloride	101-110	acetylcholinesterase (Cartwright blood group)	Homo sapiens	62-66
2332047-3	1990	On the other hand, when added to a mixture of cholinesterase (AChE and BChE) and neutral substrates, amiloride, in some cases, enhanced the reaction rate.	Amiloride	101-110	butyrylcholinesterase	Homo sapiens	71-75
2332047-4	1990	The rate of the reaction of butyrylcholinesterase with p-nitrophenyl butyrate was increased up to 12 fold by amiloride.	Amiloride	109-118	butyrylcholinesterase	Homo sapiens	28-49
2166273-6	1990	After the acid-loading procedure, cultured proximal cells recovered their pHi by means of the classic Na+/H+ antiporter, sensitive to amiloride and located in the apical membrane only.	Amiloride	134-143	glucose-6-phosphate isomerase	Oryctolagus cuniculus	74-77
2156445-6	1990	Recovery of pHi was dependent on luminal Na+ (apparent Km = 13.2 +/- 3.2 mM) and was inhibited by amiloride (apparent Ki = 10.6 microM), consistent with the activity of an apical Na(+)-H+ antiporter.	Amiloride	98-107	glucose-6-phosphate isomerase 1	Mus musculus	12-15
2160828-2	1990	In initial studies to characterize Na+/H+ exchange in FRTL-5 cell suspensions, the recovery of a resting pHi in acid-loaded cells was shown to be dependent upon the presence of extracellular Na+, was enhanced by the presence of the sodium ionophore monensin and was abolished by amiloride, an antagonist of Na+/H+ antiport activity.	Amiloride	279-288	glucose-6-phosphate isomerase	Rattus norvegicus	105-108
2160828-6	1990	However, blockade of transmembrane Na+/H+ exchange with amiloride inhibited both the individual actions of IGF-I and PMA on [methyl-3H]thymidine incorporation, and the synergistic interaction between TSH and IGF-I.	Amiloride	56-65	insulin-like growth factor 1	Rattus norvegicus	107-112
2160828-6	1990	However, blockade of transmembrane Na+/H+ exchange with amiloride inhibited both the individual actions of IGF-I and PMA on [methyl-3H]thymidine incorporation, and the synergistic interaction between TSH and IGF-I.	Amiloride	56-65	insulin-like growth factor 1	Rattus norvegicus	208-213
2156871-4	1990	In fact, the GM-CSF-dependent proliferation of AML-193 cells is strongly reduced in the presence of the amiloride analog EIPA, a specific inhibitor of the Na+/H+ exchanger.	Amiloride	104-113	colony stimulating factor 2	Homo sapiens	13-19
1696995-5	1990	Amiloride (10 to 300 microM) affected to only a small extent the increased contractile force in the presence of inotropic interventions known to increase Ca2+ influx via L-type calcium channels (Bay K 8644) and the Na/Ca exchanger (reduced extracellular Na+).	Amiloride	0-9	solute carrier family 8 member A1	Rattus norvegicus	215-230
2156437-6	1990	Actively growing cells, defined by [3H]thymidine incorporations, demonstrated an amiloride-sensitive Na(+)-dependent pHi recovery after an acid load.	Amiloride	81-90	glucose-6-phosphate isomerase	Rattus norvegicus	117-120
2354220-4	1990	Cd2+ (5 mM) causes a complete inhibition of active Ca2+ transport, whereas Mn2+ and Mg2+ inhibit this process by 85% and 35%, respectively; amiloride (500 microM) is fairly ineffective.	Amiloride	140-149	CD2 molecule	Homo sapiens	0-3
2107748-5	1990	Steady-state pHi of BC3H-1 cells in NHB acidified reversibly on exposure to 0.5 mM 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (DIDS; 1.4 +/- 0.3 x 10(-4) pH/s), 1 mM amiloride (2.0 +/- 0.7 x 10(-4) pH/s), or Na-free solution (8.3 +/- 2.4 x 10(-4) pH/s) and alkalinized upon exposure to Cl-free solutions (9.7 +/- 2.2 x 10(-4) pH/s).	Amiloride	172-181	glucose-6-phosphate isomerase 1	Mus musculus	13-16
2156445-6	1990	Recovery of pHi was dependent on luminal Na+ (apparent Km = 13.2 +/- 3.2 mM) and was inhibited by amiloride (apparent Ki = 10.6 microM), consistent with the activity of an apical Na(+)-H+ antiporter.	Amiloride	98-107	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	179-198
2107748-7	1990	This new steady-state pHi acidified very slowly upon exposure to 1 mM amiloride (0.3 +/- 0.1 x 10(-4) pH/s), acidified more rapidly upon exposure to 0.5 mM DIDS (5.9 +/- 0.6 x 10(-4) pH/s) or Na-free solutions (9.8 +/- 1.0 x 10(-4) pH/s), and alkalinized on exposure to Cl-free solutions (24.5 +/- 1.3 x 10(-4) pH/s).	Amiloride	70-79	glucose-6-phosphate isomerase 1	Mus musculus	22-25
2138237-8	1990	These findings suggest that ANP increases distal sodium delivery, and decreases sodium reabsorption in distal segments by a mechanism also sensitive to amiloride.	Amiloride	152-161	natriuretic peptide A	Homo sapiens	28-31
2155021-5	1990	pHi recovery after intracellular acid loading was partially dependent on the presence of Na+ in the extracellular medium, and was partially inhibited by the Na+/H+ antiport inhibitor, amiloride.	Amiloride	184-193	glucose-6-phosphate isomerase	Homo sapiens	0-3
2163058-1	1990	Amiloride analogs that were designed to inhibit three types of Na+ transport systems (the epithelial Na+ channel, the Na+/H+ antiporter, and the Na+/Ca++ exchanger) were applied to the tongue of the gerbil to determine their effects of electrophysiological taste responses to NaCl, CaCl2, sucrose, and glutamic acid.	Amiloride	0-9	solute carrier family 8 member A1	Homo sapiens	145-163
2155826-1	1990	Cytotoxicity of tumor necrosis factor (TNF) on L929s cells was efficiently blocked by several amiloride analogs but not by amiloride itself.	Amiloride	94-103	tumor necrosis factor	Mus musculus	39-42
2155826-1	1990	Cytotoxicity of tumor necrosis factor (TNF) on L929s cells was efficiently blocked by several amiloride analogs but not by amiloride itself.	Amiloride	123-132	tumor necrosis factor	Mus musculus	39-42
2155021-8	1990	40% of total pHi recovery was insensitive to amiloride and independent of extracellular Na+.	Amiloride	45-54	glucose-6-phosphate isomerase	Homo sapiens	13-16
2155826-4	1990	Similar protection against TNF-mediated cell lysis by amiloride derivatives was found for LAP and L929s cells, excluding a blockade of the Na+/H+ antiporter as the cause of the protection against TNF by these agents.	Amiloride	54-63	tumor necrosis factor	Mus musculus	27-30
1689673-3	1990	Furthermore, Mn2+/Mg2+ antiport and Na+/Mg2+ antiport were identically inhibited by various amiloride derivatives.	Amiloride	92-101	mucin 7, secreted	Homo sapiens	18-21
2155826-4	1990	Similar protection against TNF-mediated cell lysis by amiloride derivatives was found for LAP and L929s cells, excluding a blockade of the Na+/H+ antiporter as the cause of the protection against TNF by these agents.	Amiloride	54-63	eye lens aplasia	Mus musculus	90-93
2352189-15	1990	The presence of amiloride (1 mM) during acidosis induced by NH4Cl withdrawal abolished the observed differences in developed tension, in particular the transient recovery of tension, between normal and diabetic muscles, as it abolished the differences in the amplitude of pHi decrease and in the time course of pHi recovery.	Amiloride	16-25	glucose-6-phosphate isomerase	Rattus norvegicus	272-275
2352189-15	1990	The presence of amiloride (1 mM) during acidosis induced by NH4Cl withdrawal abolished the observed differences in developed tension, in particular the transient recovery of tension, between normal and diabetic muscles, as it abolished the differences in the amplitude of pHi decrease and in the time course of pHi recovery.	Amiloride	16-25	glucose-6-phosphate isomerase	Rattus norvegicus	311-314
2154379-6	1990	EGF, ClPhScAMP and PMA significantly increased the amiloride-inhibitable accumulation of 22Na+, thus providing further evidence that Na+/H+ exchange is stimulated by these effectors.	Amiloride	51-60	epidermal growth factor like 1	Rattus norvegicus	0-3
2154379-2	1990	The rate of amiloride-sensitive Na(+)-dependent recovery from cytoplasmic-acid-loading was found to be increased in cells treated with epidermal growth factor (EGF), 8-(4-chlorophenylthio)adenosine 3",5"-monophosphate (ClPhScAMP) or phorbol 12-myristate 13-acetate (PMA).	Amiloride	12-21	epidermal growth factor like 1	Rattus norvegicus	135-158
2154379-2	1990	The rate of amiloride-sensitive Na(+)-dependent recovery from cytoplasmic-acid-loading was found to be increased in cells treated with epidermal growth factor (EGF), 8-(4-chlorophenylthio)adenosine 3",5"-monophosphate (ClPhScAMP) or phorbol 12-myristate 13-acetate (PMA).	Amiloride	12-21	epidermal growth factor like 1	Rattus norvegicus	160-163
1689673-3	1990	Furthermore, Mn2+/Mg2+ antiport and Na+/Mg2+ antiport were identically inhibited by various amiloride derivatives.	Amiloride	92-101	mucin 7, secreted	Homo sapiens	40-43
2145725-8	1990	Although, by luminal administration of ANF in vivo, we were able to confirm an amiloride-like action of the hormone at this site, we could not thereby mimic the effects of systemic ANF on MCD Na reabsorption.	Amiloride	79-88	natriuretic peptide A	Rattus norvegicus	39-42
2298725-8	1990	Our results clearly show that the PDGF- and TPA-stimulated transmodulation of the EGF receptor does not require external sodium nor is the process affected by amiloride.	Amiloride	159-168	epidermal growth factor	Mus musculus	82-85
2305869-8	1990	Because amiloride blocked the VIP-stimulated active K+ component, the VIP effects on active K+ influx may be secondary to a Na(+)-H+ antiporter-mediated increase in cellular Na+ content.	Amiloride	8-17	vasoactive intestinal peptide	Homo sapiens	30-33
2305869-8	1990	Because amiloride blocked the VIP-stimulated active K+ component, the VIP effects on active K+ influx may be secondary to a Na(+)-H+ antiporter-mediated increase in cellular Na+ content.	Amiloride	8-17	vasoactive intestinal peptide	Homo sapiens	70-73
2305896-5	1990	Omission of Na+ or addition of 1 mM amiloride prevented the decline in pHi.	Amiloride	36-45	glucose-6-phosphate isomerase	Rattus norvegicus	71-74
2305896-7	1990	In contrast, during RVI, pHi increased from 6.86 +/- 0.11 to 7.15 +/- 0.15 in the absence of HCO3-, a rise in pHi that was also completely abolished by Na+ removal or by 1 mM amiloride.	Amiloride	175-184	glucose-6-phosphate isomerase	Rattus norvegicus	25-28
2305896-7	1990	In contrast, during RVI, pHi increased from 6.86 +/- 0.11 to 7.15 +/- 0.15 in the absence of HCO3-, a rise in pHi that was also completely abolished by Na+ removal or by 1 mM amiloride.	Amiloride	175-184	glucose-6-phosphate isomerase	Rattus norvegicus	110-113
2328017-2	1990	LDL and apoprotein B (apo-B), a binding protein for the LDL receptor, caused transient acidification followed by Na(+)-dependent and amiloride-sensitive alkalization of the cells due to stimulation of Na+/H+ exchanger.	Amiloride	133-142	low density lipoprotein receptor	Homo sapiens	56-68
2154185-6	1990	Both agonists do, however, share an ability to activate an amiloride-sensitive Na+/H+ antiport and, furthermore, amiloride analogues are shown to inhibit the proliferative effects of GM-CSF on these cells.	Amiloride	59-68	colony stimulating factor 2	Homo sapiens	183-189
2154185-6	1990	Both agonists do, however, share an ability to activate an amiloride-sensitive Na+/H+ antiport and, furthermore, amiloride analogues are shown to inhibit the proliferative effects of GM-CSF on these cells.	Amiloride	113-122	colony stimulating factor 2	Homo sapiens	183-189
2158787-2	1990	In the concentration range 100-250 microM, amiloride progessively inhibited 14C-thymidine incorporation induced by insulin, EGF or prolactin.	Amiloride	43-52	insulin	Oryctolagus cuniculus	115-122
2159762-5	1990	Activation of the CSF-1 receptor by its ligand was evidenced by the rapid activation of the Na+/H+ exchanger resulting in amiloride-sensitive cytoplasmic alkalinization (0.1-0.2 pH units) within minutes after stimulation.	Amiloride	122-131	colony stimulating factor 1	Homo sapiens	18-23
2297454-5	1990	The renal clearance of amiloride was lower in the elderly than in young subjects (102 +/- 36 ml min -1 vs 300 +/- 64 ml min-1, P less than 0.001) as was the urinary excretion of amiloride (36 +/- 13 vs 62 +/- 18% of the dose, P less than 0.01).	Amiloride	23-32	CD59 molecule (CD59 blood group)	Homo sapiens	96-102
2158787-2	1990	In the concentration range 100-250 microM, amiloride progessively inhibited 14C-thymidine incorporation induced by insulin, EGF or prolactin.	Amiloride	43-52	pro-epidermal growth factor	Oryctolagus cuniculus	124-127
34898192-6	2022	The study will guide further optimization of dual-potent human/mouse uPA inhibitors from the amiloride class as antimetastasis drugs.	Amiloride	93-102	plasminogen activator, urokinase	Mus musculus	69-72
33804289-5	2021	Together, these amilorides comprise a new toolkit of chemotype-matched, non-cytotoxic probes for dissecting the pharmacological effects of selective uPA and NHE1 inhibition versus dual-uPA/NHE1 inhibition.	Amiloride	16-26	plasminogen activator, urokinase	Homo sapiens	149-152
33804289-5	2021	Together, these amilorides comprise a new toolkit of chemotype-matched, non-cytotoxic probes for dissecting the pharmacological effects of selective uPA and NHE1 inhibition versus dual-uPA/NHE1 inhibition.	Amiloride	16-26	solute carrier family 9 member A1	Homo sapiens	157-161
33804289-5	2021	Together, these amilorides comprise a new toolkit of chemotype-matched, non-cytotoxic probes for dissecting the pharmacological effects of selective uPA and NHE1 inhibition versus dual-uPA/NHE1 inhibition.	Amiloride	16-26	plasminogen activator, urokinase	Homo sapiens	185-188
33804289-5	2021	Together, these amilorides comprise a new toolkit of chemotype-matched, non-cytotoxic probes for dissecting the pharmacological effects of selective uPA and NHE1 inhibition versus dual-uPA/NHE1 inhibition.	Amiloride	16-26	solute carrier family 9 member A1	Homo sapiens	189-193
29958884-4	2018	Wstern blot analysis was performed to investigate the effect of amiloride on the level of proteins in uPA system, NF-kB pathway, and PI3K-AKT-mTOR pathway in CSCs.	Amiloride	64-73	proline rich acidic protein 1	Homo sapiens	102-105
29958884-6	2018	Further, we found that amiloride decreased levels of target proteins in the uPA system, as well as the NF-kB and PI3K-AKT-mTOR pathways.	Amiloride	23-32	proline rich acidic protein 1	Homo sapiens	76-79
29958884-7	2018	These results indicated that amiloride could inhibit proliferation, migration and invasion of lung CSCs, and promotes apoptosis, these effects may be related to decreased levels of proteins in the uPA system, the NF-kB pathway, and the PI3K-AKT-mTOR pathway.	Amiloride	29-38	proline rich acidic protein 1	Homo sapiens	197-200
8797088-6	1996	When the cytoplasmic pH was lowered by chasing cells that had been preincubated with 25 mM NH4Cl in an amiloride-containing Na(+)-free medium, more than 90% of internalization of Tfn in HT-1080 cells was inhibited, while that of HRP was reduced by only 35%.	Amiloride	103-112	transferrin	Homo sapiens	179-182
34914636-4	2022	This was associated with a significantly lower response to the epithelial Na+ channel (ENaC) blocker amiloride, reduced ENaC activity in split-opened collecting ducts, and defective posttranslational processing of alpha and gammaENaC subunits in the knockout mice fed with Na+ deficient diet.	Amiloride	101-110	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	63-85
34914636-4	2022	This was associated with a significantly lower response to the epithelial Na+ channel (ENaC) blocker amiloride, reduced ENaC activity in split-opened collecting ducts, and defective posttranslational processing of alpha and gammaENaC subunits in the knockout mice fed with Na+ deficient diet.	Amiloride	101-110	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	87-91
17323380-8	2007	Finally, co-stimulation with PHA and progesterone or amiloride, (5-(N, N-dimethyl)-amiloride, DMA), inhibited PHA-induced T-cell proliferation, but this inhibition did not occur with 20alpha-OHP and PHA co-stimulation.	Amiloride	53-62	major histocompatibility complex, class II, DM alpha	Homo sapiens	94-97
34843409-8	2022	Amiloride-sensitive Na+ currents in DCT2/iCNT and CCD were significantly higher in Ks-Nedd4-2-KO mice than floxed-Nedd4l mice on normal-K+-diet.	Amiloride	0-9	neural precursor cell expressed, developmentally down-regulated 4	Mus musculus	86-91
34843409-8	2022	Amiloride-sensitive Na+ currents in DCT2/iCNT and CCD were significantly higher in Ks-Nedd4-2-KO mice than floxed-Nedd4l mice on normal-K+-diet.	Amiloride	0-9	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	114-120
34843409-10	2022	Moreover, HK-induced increase in amiloride-sensitive Na+-currents was larger in Ks-Nedd4-2-KO mice than the control mice.	Amiloride	33-42	neural precursor cell expressed, developmentally down-regulated 4	Mus musculus	83-88
34656704-3	2022	Amiloride (AML) is an antihypertensive, potassium-sparing diuretic that has been proven to be neuroprotective in different experimental models; this can be attributed to its ability to inhibit different ion transporters such as Na+/H+ exchanger (NHE), which upon excessive activation can result in intracellular cationic overload, followed by oxidative damage and cellular death.	Amiloride	0-9	solute carrier family 9 member C1	Homo sapiens	228-244
34656704-3	2022	Amiloride (AML) is an antihypertensive, potassium-sparing diuretic that has been proven to be neuroprotective in different experimental models; this can be attributed to its ability to inhibit different ion transporters such as Na+/H+ exchanger (NHE), which upon excessive activation can result in intracellular cationic overload, followed by oxidative damage and cellular death.	Amiloride	0-9	solute carrier family 9 member C1	Homo sapiens	246-249
34656704-3	2022	Amiloride (AML) is an antihypertensive, potassium-sparing diuretic that has been proven to be neuroprotective in different experimental models; this can be attributed to its ability to inhibit different ion transporters such as Na+/H+ exchanger (NHE), which upon excessive activation can result in intracellular cationic overload, followed by oxidative damage and cellular death.	Amiloride	11-14	solute carrier family 9 member C1	Homo sapiens	228-244
34656704-3	2022	Amiloride (AML) is an antihypertensive, potassium-sparing diuretic that has been proven to be neuroprotective in different experimental models; this can be attributed to its ability to inhibit different ion transporters such as Na+/H+ exchanger (NHE), which upon excessive activation can result in intracellular cationic overload, followed by oxidative damage and cellular death.	Amiloride	11-14	solute carrier family 9 member C1	Homo sapiens	246-249
34656704-9	2022	Furthermore, AML halted DOX-induced hippocampal apoptosis as evidenced by decreased caspase-3 activity and lower cytochrome c immunoexpression.	Amiloride	13-16	caspase 3	Homo sapiens	84-93
34656704-9	2022	Furthermore, AML halted DOX-induced hippocampal apoptosis as evidenced by decreased caspase-3 activity and lower cytochrome c immunoexpression.	Amiloride	13-16	cytochrome c, somatic	Homo sapiens	113-125
34615377-15	2021	Ankrd36 knockout mice also showed more sensitive response to ENaC inhibitor amiloride treatment.	Amiloride	76-85	ankyrin repeat domain 36	Mus musculus	0-7
34704597-9	2021	Surprisingly, the transport function of SLC38A5 is inhibited by amilorides, the well-known inhibitors of Na+/H+ exchanger.	Amiloride	64-74	solute carrier family 38 member 5	Homo sapiens	40-47
34905147-9	2022	We documented that ARS-1620-induced inhibition of K-RAS activity or amiloride-mediated inhibition of macropinocytosis significantly reduced albumin uptake.	Amiloride	68-77	albumin	Mus musculus	140-147
34615377-15	2021	Ankrd36 knockout mice also showed more sensitive response to ENaC inhibitor amiloride treatment.	Amiloride	76-85	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	61-65
34368091-10	2021	MiR-34c could restore the AFC and lung wet/dry weight ratio in the ALI animal model, and Ussing chamber assay revealed that miR-34c enhanced the amiloride-sensitive currents associated with ENaC activity in intact H441 cell monolayers.	Amiloride	145-154	microRNA 34c	Homo sapiens	124-131
34721074-0	2021	Paradoxical Potentiation of Acid-Sensing Ion Channel 3 (ASIC3) by Amiloride via Multiple Mechanisms and Sites Within the Channel.	Amiloride	66-75	acid sensing ion channel subunit 3	Homo sapiens	28-54
34721074-0	2021	Paradoxical Potentiation of Acid-Sensing Ion Channel 3 (ASIC3) by Amiloride via Multiple Mechanisms and Sites Within the Channel.	Amiloride	66-75	acid sensing ion channel subunit 3	Homo sapiens	56-61
34721074-3	2021	However, amiloride can also cause paradoxical potentiation of ASIC currents under certain conditions.	Amiloride	9-18	acid sensing ion channel subunit 1	Homo sapiens	62-66
34721074-4	2021	Here we characterized and investigated the determinants of paradoxical potentiation by amiloride on ASIC3 channels.	Amiloride	87-96	acid sensing ion channel subunit 3	Homo sapiens	100-105
34354180-8	2021	This was corroborated by a markedly reduced ENaC activity, while amiloride-insensitive pathways as well as barrier function were raised by EGF.	Amiloride	65-74	epidermal growth factor	Homo sapiens	139-142
34395479-7	2021	Pathogenicity analysis of R227I amino acid substitution in ASIC5 protein through molecular docking and interaction analysis revealed that the mutations are highly pathogenic, decrease the stability of the protein, and prevent binding of amiloride, which is an activator to open the acid-sensing ion channel of ASIC5.	Amiloride	237-246	acid sensing ion channel subunit family member 5	Homo sapiens	59-64
34395479-7	2021	Pathogenicity analysis of R227I amino acid substitution in ASIC5 protein through molecular docking and interaction analysis revealed that the mutations are highly pathogenic, decrease the stability of the protein, and prevent binding of amiloride, which is an activator to open the acid-sensing ion channel of ASIC5.	Amiloride	237-246	acid sensing ion channel subunit family member 5	Homo sapiens	310-315
34343209-10	2021	ET-1-induced contraction was not affected by amlodipine, a VDCC blocker, whereas it was partly reduced by Gd3+ and amiloride, non-selective cation channel blockers.	Amiloride	115-124	endothelin 1	Mus musculus	0-4
34143184-2	2021	Under basal dietary conditions (0.5% K), ENaC activity, measured as amiloride-sensitive currents, was high in cells at the distal end of the distal convoluted tubule (DCT) and proximal end of the connecting tubule (CNT), a region we call the early CNT (CNTe).	Amiloride	68-77	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	41-45
34368091-10	2021	MiR-34c could restore the AFC and lung wet/dry weight ratio in the ALI animal model, and Ussing chamber assay revealed that miR-34c enhanced the amiloride-sensitive currents associated with ENaC activity in intact H441 cell monolayers.	Amiloride	145-154	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	190-194
35512853-2	2022	Inhibition of amiloride-sensitive epithelial sodium ion channel (ENaC) has now been considered as a potential therapeutic target against COPD.	Amiloride	14-23	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	65-69
34122084-7	2021	CsA elevated systolic blood pressure in rats; the elevation was completely reversed by lovastatin (an inhibitor of cholesterol synthesis), NaHS (a donor of H2S which ameliorated CsA-induced elevation of reactive oxygen species), or amiloride (a potent ENaC blocker).	Amiloride	232-241	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	252-256
35044984-13	2022	In patients with severe HSD11B2 mutation, combination therapy of spironolactone with amiloride could be effective in controlling blood pressure.	Amiloride	85-94	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	24-31
35624145-7	2022	Plasma from patients taking amiloride for diuresis reduced pHi of leukemia and enhanced cytotoxic effects of kinase inhibitors and chemotherapy in vitro.	Amiloride	28-37	glucose-6-phosphate isomerase	Homo sapiens	59-62
35538691-6	2022	Low pHe reduced intracellular pH (pHi), while amiloride treatment, which is known to reduce pHi, induced c-Src phosphorylation through AhR.	Amiloride	46-55	aryl-hydrocarbon receptor	Mus musculus	135-138
35569011-7	2022	In DIN and Nphs2Deltaipod mice, inhibition of ENaC by amiloride or urinary serine protease activity by aprotinin prevents sodium retention, opening up new and promising therapeutic approaches that could be translated into the treatment of nephrotic patients.	Amiloride	54-63	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	46-50
35538691-6	2022	Low pHe reduced intracellular pH (pHi), while amiloride treatment, which is known to reduce pHi, induced c-Src phosphorylation through AhR.	Amiloride	46-55	glucose-6-phosphate isomerase 1	Mus musculus	92-95
35538691-6	2022	Low pHe reduced intracellular pH (pHi), while amiloride treatment, which is known to reduce pHi, induced c-Src phosphorylation through AhR.	Amiloride	46-55	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-110
35445658-0	2022	Novel intranasal treatment for anxiety disorders using amiloride, an acid-sensing ion channel antagonist: Pharmacokinetic modeling and simulation.	Amiloride	55-64	acid sensing ion channel subunit 1	Homo sapiens	69-93
35601958-3	2022	TIP peptide, AP301) is a 17-mer cyclic peptide that mimics the LLD of human TNF which activates the amiloride-sensitive epithelial sodium channel (ENaC) and, as such, recapitulates the capacity of TNF to enhance alveolar fluid clearance, as demonstrated in numerous preclinical studies.	Amiloride	100-109	tumor necrosis factor	Homo sapiens	76-79
35445658-1	2022	OBJECTIVE: To develop a physiologically based pharmacokinetic (PBPK) model for amiloride, an acid-sensing ion channel (ASIC) antagonist, and to simulate its pharmacokinetics in plasma and the central nervous system following intranasal administration in a virtual human population.	Amiloride	79-88	acid sensing ion channel subunit 1	Homo sapiens	93-117
35445658-1	2022	OBJECTIVE: To develop a physiologically based pharmacokinetic (PBPK) model for amiloride, an acid-sensing ion channel (ASIC) antagonist, and to simulate its pharmacokinetics in plasma and the central nervous system following intranasal administration in a virtual human population.	Amiloride	79-88	acid sensing ion channel subunit 1	Homo sapiens	119-123
35445658-5	2022	RESULTS: The target amiloride concentration in the central nervous system required for maximal ASIC inhibition was achieved with a 75-mg intranasal amiloride dose.	Amiloride	20-29	acid sensing ion channel subunit 1	Homo sapiens	95-99
35445658-5	2022	RESULTS: The target amiloride concentration in the central nervous system required for maximal ASIC inhibition was achieved with a 75-mg intranasal amiloride dose.	Amiloride	148-157	acid sensing ion channel subunit 1	Homo sapiens	95-99
35042121-0	2022	Amiloride is a suitable fluorescent substrate for the study of the drug transporter human multidrug and toxin extrusion 1 (MATE1).	Amiloride	0-9	solute carrier family 47 member 1	Homo sapiens	90-121
35384364-8	2022	ENaC"s contribution was assessed with the use of the specific inhibitor amiloride.	Amiloride	72-81	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	0-4
35042121-0	2022	Amiloride is a suitable fluorescent substrate for the study of the drug transporter human multidrug and toxin extrusion 1 (MATE1).	Amiloride	0-9	solute carrier family 47 member 1	Homo sapiens	123-128
35042121-4	2022	In this study, we investigated the transport characteristics of amiloride by human MATE1.	Amiloride	64-73	solute carrier family 47 member 1	Homo sapiens	83-88
35042121-7	2022	With ammonium prepulse-induced intracellular acidification, MATE1 transported amiloride at an extracellular pH of 7.4.	Amiloride	78-87	solute carrier family 47 member 1	Homo sapiens	60-65
35042121-9	2022	MATE1-mediated amiloride transport also presented with a bell-shaped pH profile that reached a maximum pH value of 7.4.	Amiloride	15-24	solute carrier family 47 member 1	Homo sapiens	0-5
35042121-10	2022	The inhibitor sensitivity of MATE1-facilitated amiloride transport was similar to those of known substrates, such as tetraethylammonium and metformin.	Amiloride	47-56	solute carrier family 47 member 1	Homo sapiens	29-34
35042121-13	2022	This study demonstrates that amiloride is a suitable fluorescent substrate for the in vitro study of the transport activity of MATE1.	Amiloride	29-38	solute carrier family 47 member 1	Homo sapiens	127-132
35126174-8	2021	Of note, inhibiting ASIC1 activation with amiloride or Psalmotoxin 1 (PcTx-1) not only lowered calpain1 protein level and lipid accumulation but also enhanced ABCA1 protein levels and ABCA1-mediated cholesterol efflux of macrophages under extracellular acidification conditions.	Amiloride	42-51	acid sensing ion channel subunit 1	Homo sapiens	20-25
35224872-8	2022	Moreover, we found that Sgk1Pax8 / LC1  mice reduce NCC phosphorylation and NCC-mediated salt absorption to a greater extent than control mice after a K+ load, promoting increased amiloride-sensitive Na+ -reabsorption via ENaC to maintain adequate kaliuresis.	Amiloride	180-189	serum/glucocorticoid regulated kinase 1	Mus musculus	24-32
35224872-8	2022	Moreover, we found that Sgk1Pax8 / LC1  mice reduce NCC phosphorylation and NCC-mediated salt absorption to a greater extent than control mice after a K+ load, promoting increased amiloride-sensitive Na+ -reabsorption via ENaC to maintain adequate kaliuresis.	Amiloride	180-189	microtubule-associated protein 1B	Mus musculus	35-38
35178382-13	2022	When the Sa12b concentration was 8 mug/mul and contained the ASIC non-specific inhibitor amiloride, the Ca2+ influx was the lowest, followed by that when the Sa12b concentration was 8 mug/mul.	Amiloride	89-98	acid sensing ion channel subunit 1	Homo sapiens	61-65
35126174-8	2021	Of note, inhibiting ASIC1 activation with amiloride or Psalmotoxin 1 (PcTx-1) not only lowered calpain1 protein level and lipid accumulation but also enhanced ABCA1 protein levels and ABCA1-mediated cholesterol efflux of macrophages under extracellular acidification conditions.	Amiloride	42-51	calpain 1	Homo sapiens	95-103
35126174-8	2021	Of note, inhibiting ASIC1 activation with amiloride or Psalmotoxin 1 (PcTx-1) not only lowered calpain1 protein level and lipid accumulation but also enhanced ABCA1 protein levels and ABCA1-mediated cholesterol efflux of macrophages under extracellular acidification conditions.	Amiloride	42-51	ATP binding cassette subfamily A member 1	Homo sapiens	159-164
35126174-8	2021	Of note, inhibiting ASIC1 activation with amiloride or Psalmotoxin 1 (PcTx-1) not only lowered calpain1 protein level and lipid accumulation but also enhanced ABCA1 protein levels and ABCA1-mediated cholesterol efflux of macrophages under extracellular acidification conditions.	Amiloride	42-51	ATP binding cassette subfamily A member 1	Homo sapiens	184-189
2557088-0	1989	Amiloride activation of hepatic microsomal glucose-6-phosphatase; activation of T1?	Amiloride	0-9	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	43-64
2574175-4	1989	These pHi changes were dependent on extracellular Na+ and inhibited by amiloride.	Amiloride	71-80	glucose-6-phosphate isomerase 1	Mus musculus	6-9
2556473-8	1989	The IL-1-induced rise in pHi is both sodium dependent and amiloride sensitive, indicative of activation of the Na+/H+ antiport.	Amiloride	58-67	interleukin 1 complex	Mus musculus	4-8
2556473-8	1989	The IL-1-induced rise in pHi is both sodium dependent and amiloride sensitive, indicative of activation of the Na+/H+ antiport.	Amiloride	58-67	glucose-6-phosphate isomerase 1	Mus musculus	25-28
2557088-1	1989	The mechanism of activation of hepatic microsomal glucose-6-phosphatase (EC 3.1.3.9) in vitro by amiloride has been investigated in both intact and fully disrupted microsomes.	Amiloride	97-106	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	50-71
2557088-2	1989	The major effect of amiloride is a 4.5-fold reduction in the Km of glucose-6-phosphatase activity in intact diabetic rat liver microsomes.	Amiloride	20-29	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	67-88
2557088-3	1989	Amiloride also decreased the Km of glucose-6-phosphatase activity in intact liver microsomes isolated from starved rats 2.5-fold.	Amiloride	0-9	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	35-56
2603961-6	1989	However, a slow pHi decrease was observed in response to bath Na+ removal when the bath fluid contained ACTZ and the luminal fluid contained 4 mM amiloride.	Amiloride	146-155	glucose-6-phosphate isomerase	Oryctolagus cuniculus	16-19
2553866-0	1989	Atrial natriuretic peptide modulates amiloride-sensitive Na+ transport across the blood-brain barrier.	Amiloride	37-46	natriuretic peptide A	Rattus norvegicus	0-26
2610271-2	1989	Intracellular pH (pHi) was acutely lowered by NH3 prepulse in HCO3(-)-free medium buffered with 6 mM N-2-hydroxyethylpiperazine-N"-2-ethanesulfonic acid, and its recovery was measured thereafter under control conditions, in the presence of amiloride to inhibit Na(+)-H+ antiport, and in the presence of N-ethylmaleimide (NEM), a plasma membrane H(+)-ATPase inhibitor.	Amiloride	240-249	glucose-6-phosphate isomerase	Rattus norvegicus	18-21
2610271-3	1989	Initial rate of pHi recovery was reduced by 67% in the presence of amiloride, 52% in the presence of NEM, and 96% in the presence of both.	Amiloride	67-76	glucose-6-phosphate isomerase	Rattus norvegicus	16-19
2553866-1	1989	We obtained evidence that amiloride specifically potentiates 125I-labeled alpha-rat atrial natriuretic peptide (1-28) [atrial natriuretic peptide (ANP)-(99-126); rANP] binding to cerebral capillaries isolated from the rat cerebral cortex.	Amiloride	26-35	natriuretic peptide A	Rattus norvegicus	84-110
2553866-1	1989	We obtained evidence that amiloride specifically potentiates 125I-labeled alpha-rat atrial natriuretic peptide (1-28) [atrial natriuretic peptide (ANP)-(99-126); rANP] binding to cerebral capillaries isolated from the rat cerebral cortex.	Amiloride	26-35	natriuretic peptide A	Rattus norvegicus	119-145
2553866-1	1989	We obtained evidence that amiloride specifically potentiates 125I-labeled alpha-rat atrial natriuretic peptide (1-28) [atrial natriuretic peptide (ANP)-(99-126); rANP] binding to cerebral capillaries isolated from the rat cerebral cortex.	Amiloride	26-35	natriuretic peptide A	Rattus norvegicus	147-150
2553866-1	1989	We obtained evidence that amiloride specifically potentiates 125I-labeled alpha-rat atrial natriuretic peptide (1-28) [atrial natriuretic peptide (ANP)-(99-126); rANP] binding to cerebral capillaries isolated from the rat cerebral cortex.	Amiloride	26-35	natriuretic peptide A	Rattus norvegicus	162-166
2553866-3	1989	When the effect of rANP was investigated on in vitro 22Na+ uptake into isolated cerebral capillaries, 10(-7) M rANP significantly inhibited the uptake in the presence of 1.0 mM ouabain, 1.0 mM furosemide, and 2.0 mM LiCl in the uptake buffer, a finding suggesting a specific inhibitory effect of rANP on amiloride-sensitive Na+ transport.	Amiloride	304-313	natriuretic peptide A	Rattus norvegicus	111-115
2553866-3	1989	When the effect of rANP was investigated on in vitro 22Na+ uptake into isolated cerebral capillaries, 10(-7) M rANP significantly inhibited the uptake in the presence of 1.0 mM ouabain, 1.0 mM furosemide, and 2.0 mM LiCl in the uptake buffer, a finding suggesting a specific inhibitory effect of rANP on amiloride-sensitive Na+ transport.	Amiloride	304-313	natriuretic peptide A	Rattus norvegicus	111-115
2559811-6	1989	The organic base, amiloride was identified as an inhibitor of the activity, the degree of inhibition being most marked in the presence of Ca2+ and calmodulin (K0.5 approx.	Amiloride	18-27	calmodulin	Bos taurus	147-157
2555323-3	1989	Thrombin (10 nM) induced an alkalinization (0.18 +/- 0.01 pH units, n = 23) that was Na+-dependent and amiloride-sensitive, suggesting that the alkalinization was mediated by the Na+/H+ exchanger.	Amiloride	103-112	coagulation factor II, thrombin	Homo sapiens	0-8
2555323-10	1989	The increase in pHi due to ionomycin was dependent on Na+ and sensitive to amiloride.	Amiloride	75-84	glucose-6-phosphate isomerase	Homo sapiens	16-19
2553110-4	1989	Amiloride, an inhibitor of the plasma-membrane-bound Na+/H+ antiporter, was found to inhibit the mitogenic effects of prolactin.	Amiloride	0-9	prolactin	Homo sapiens	118-127
2553110-5	1989	Amiloride was also found to inhibit the prolactin stimulation of DNA, RNA and protein synthesis, thus suggesting that the initial regulation of the Na+/H+ antiporter may initiate these responses as well as the mitogenic effect of prolactin.	Amiloride	0-9	prolactin	Homo sapiens	40-49
2553110-5	1989	Amiloride was also found to inhibit the prolactin stimulation of DNA, RNA and protein synthesis, thus suggesting that the initial regulation of the Na+/H+ antiporter may initiate these responses as well as the mitogenic effect of prolactin.	Amiloride	0-9	prolactin	Homo sapiens	230-239
2551179-4	1989	Amiloride (0.1 mM) caused pHi to decrease by 0.33 pH units in 4 min.	Amiloride	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	26-29
2554221-4	1989	Amiloride reduced strongly the T-type Ca2+ current without affecting the L-type one.	Amiloride	0-9	carbonic anhydrase 2	Rattus norvegicus	38-41
2608159-5	1989	The AGF2-treated cultures showed highly increased, amiloride-sensitive INa at the early exposure period (2-8 hours), similar to that we have reported about cultured astroglia exposed to AGF2 for minutes.	Amiloride	51-60	internexin neuronal intermediate filament protein, alpha	Rattus norvegicus	71-74
2608159-7	1989	However, at later periods of exposure to AGF2, INa was significantly reduced, particularly due to the decrease of its amiloride-sensitive component, while its furosemide-sensitive component further increased with the time of AGF2 treatment.	Amiloride	118-127	internexin neuronal intermediate filament protein, alpha	Rattus norvegicus	47-50
2551067-2	1989	The pHc increased with the stimulation in an amiloride-sensitive manner only when the resting-pHc was lower than a certain value (pHc 6.99 for thrombin-stimulation, 6.95 for AA, 7.04 for A23187 and 6.95 for TPA, n = 3).	Amiloride	45-54	solute carrier family 25 member 3	Homo sapiens	4-7
2551067-2	1989	The pHc increased with the stimulation in an amiloride-sensitive manner only when the resting-pHc was lower than a certain value (pHc 6.99 for thrombin-stimulation, 6.95 for AA, 7.04 for A23187 and 6.95 for TPA, n = 3).	Amiloride	45-54	solute carrier family 25 member 3	Homo sapiens	94-97
2551067-2	1989	The pHc increased with the stimulation in an amiloride-sensitive manner only when the resting-pHc was lower than a certain value (pHc 6.99 for thrombin-stimulation, 6.95 for AA, 7.04 for A23187 and 6.95 for TPA, n = 3).	Amiloride	45-54	solute carrier family 25 member 3	Homo sapiens	94-97
2551067-2	1989	The pHc increased with the stimulation in an amiloride-sensitive manner only when the resting-pHc was lower than a certain value (pHc 6.99 for thrombin-stimulation, 6.95 for AA, 7.04 for A23187 and 6.95 for TPA, n = 3).	Amiloride	45-54	coagulation factor II, thrombin	Homo sapiens	143-151
2476937-7	1989	Amiloride or Na-free solution (which should reverse the Na-H exchanger and cause cellular acidification) caused pHi to decrease 2.5 or 5 times, respectively, more slowly in stimulated PC compared with resting PC.	Amiloride	0-9	glucose-6-phosphate isomerase	Oryctolagus cuniculus	112-115
2782409-5	1989	In solutions containing 1 mM amiloride, which blocked Na-H exchange, pHi recovered only if Na and HCO3 were both present.	Amiloride	29-38	glucose-6-phosphate isomerase	Oryctolagus cuniculus	69-72
2551179-7	1989	Amiloride caused pHi to decrease by only 0.09 units.	Amiloride	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	17-20
2551181-6	1989	Amiloride inhibited only the recovery phases of H+ efflux and pHi.	Amiloride	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	62-65
2527500-2	1989	Amiloride, a frequently used Na+/H+ exchange inhibitor, potently inhibited phosphorylation of LC20 by MLCK.	Amiloride	0-9	myosin light chain kinase	Homo sapiens	102-106
2782409-6	1989	This amiloride-resistant, Na- and HCO3-dependent pHi recovery was inhibited by 100 microM H2 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (reversibly) and occurred at equal rates in Cl-containing and Cl-free solutions.	Amiloride	5-14	glucose-6-phosphate isomerase	Oryctolagus cuniculus	49-52
2782409-7	1989	In NaCl solutions buffered with HCO3-CO2 and containing amiloride, after an acid load pHi recovers to pHi 7.0-7.1 solely through the activity of the Na-HCO3 cotransporter.	Amiloride	56-65	glucose-6-phosphate isomerase	Oryctolagus cuniculus	86-89
2782409-7	1989	In NaCl solutions buffered with HCO3-CO2 and containing amiloride, after an acid load pHi recovers to pHi 7.0-7.1 solely through the activity of the Na-HCO3 cotransporter.	Amiloride	56-65	glucose-6-phosphate isomerase	Oryctolagus cuniculus	102-105
2556151-0	1989	Potentiation of the effects of atrial natriuretic factor on the cardiovascular system by amiloride.	Amiloride	89-98	natriuretic peptide A	Rattus norvegicus	31-56
2556151-1	1989	Amiloride has previously been shown to facilitate receptor binding of atrial natriuretic factor (ANF) to membranes of adrenal cortex and to enhance ANF induced inhibition of steroid secretion in vitro.	Amiloride	0-9	natriuretic peptide A	Rattus norvegicus	70-95
2556151-1	1989	Amiloride has previously been shown to facilitate receptor binding of atrial natriuretic factor (ANF) to membranes of adrenal cortex and to enhance ANF induced inhibition of steroid secretion in vitro.	Amiloride	0-9	natriuretic peptide A	Rattus norvegicus	97-100
2556151-1	1989	Amiloride has previously been shown to facilitate receptor binding of atrial natriuretic factor (ANF) to membranes of adrenal cortex and to enhance ANF induced inhibition of steroid secretion in vitro.	Amiloride	0-9	natriuretic peptide A	Rattus norvegicus	148-151
2556151-2	1989	This interaction of amiloride and ANF also holds true for the cardiovascular system.	Amiloride	20-29	natriuretic peptide A	Rattus norvegicus	34-37
2556151-5	1989	In spontaneously hypertensive rats ANF-induced decreases in blood pressure were potentiated by amiloride.	Amiloride	95-104	natriuretic peptide A	Rattus norvegicus	35-38
2556151-9	1989	Binding of labeled ANF to aortic tissue was concentration-dependently increased by amiloride.	Amiloride	83-92	natriuretic peptide A	Rattus norvegicus	19-22
2556151-11	1989	Therefore it can be suggested that amiloride and ATP interfere with a mechanism regulating the sensitivity of the vascular ANF-receptor for its ligand regarding binding and signal transforming presumably by a kinase mediated phosphorylation/dephosphorylation process.	Amiloride	35-44	natriuretic peptide A	Rattus norvegicus	123-126
2527500-0	1989	Inhibition of myosin light chain kinase by amiloride.	Amiloride	43-52	myosin light chain kinase	Homo sapiens	14-39
2527500-2	1989	Amiloride, a frequently used Na+/H+ exchange inhibitor, potently inhibited phosphorylation of LC20 by MLCK.	Amiloride	0-9	myosin light chain 9	Homo sapiens	94-98
2527500-3	1989	The inhibition was non-competitive with respect to myosin but competitive with ATP (Ki = 0.95 microM), suggesting that amiloride may act as an ATP analogue.	Amiloride	119-128	myosin heavy chain 14	Homo sapiens	51-57
2527500-5	1989	Thus, it must be reminded that amiloride cannot be used as a specific inhibitor of Na+/H+ exchange, and that the inhibition of myosin phosphorylation by amiloride should be taken into consideration in studying the role of Na+/H+ antiport in the cellular function.	Amiloride	153-162	myosin heavy chain 14	Homo sapiens	127-133
2743336-8	1989	The toxicity of CCCP under acidic conditions was enhanced by amiloride and 4,4"-diisothiocyanostilbene-2,2-disulfonic acid, agents which are known to inhibit membrane-based ion exchange mechanisms which regulate pHi under acidic conditions.	Amiloride	61-70	glucose-6-phosphate isomerase	Homo sapiens	212-215
2770705-1	1989	Amiloride analogues with nonaromatic substituents on the 5-amino group or different substituents on carbon-6 of the pyrazine ring were tested as inhibitors of monoamine oxidase A and B in rat brain homogenate.	Amiloride	0-9	monoamine oxidase A	Rattus norvegicus	159-184
2550619-0	1989	Inhibition of bradykinin-induced increases of cytosolic Ca++ by a novel amiloride analog.	Amiloride	72-81	kininogen 1	Canis lupus familiaris	14-24
2550619-2	1989	An amiloride analog, 5-N-N-ethyl[2-methoxy 5-nitrobenzyl]amiloride (L651,548), led to a dose-dependent inhibition of the BK-induced Ca++ transient (Ki = 9 microM), and this effect was eliminated in high external Na+.	Amiloride	3-12	kininogen 1	Canis lupus familiaris	121-123
2550619-9	1989	Also, the amiloride analog L651,548 reduces BK Ca++ release by inhibition of BK receptor binding in Madin-Darby canine kidney cells.	Amiloride	10-19	kininogen 1	Canis lupus familiaris	44-46
2770705-4	1989	A reciprocal relation was found to exist between inhibitory constants of 5-N-substituted amiloride analogues for monoamine oxidase A and the ratio of overflows of endogenous noradrenaline and 3,4-dihydroxyphenylethylene glycol from the isolated rat tail artery incubated in the presence of a 50 microM concentration of the analogue, when the tissue was exposed to 10 microM tyramine.	Amiloride	89-98	monoamine oxidase A	Rattus norvegicus	113-132
2735761-4	1989	Amiloride inhibited the vanadate-stimulated release of LPL activity in a dose-dependent manner, but did not inhibit the heparin-stimulated release of LPL activity.	Amiloride	0-9	lipoprotein lipase	Rattus norvegicus	55-58
2735761-9	1989	These findings suggest that vanadate stimulates the release of LPL activity through mechanisms of action involving amiloride-sensitive and calcium-dependent pathways with a requirement of metabolic energy.	Amiloride	115-124	lipoprotein lipase	Rattus norvegicus	63-66
2472417-8	1989	The effects of the two drugs amiloride and bumetanide on induction of three genes--c-fos, c-myc, and ornithin decarboxylase (ODC)--was measured during cell transition through the G1-phase.	Amiloride	29-38	FBJ osteosarcoma oncogene	Mus musculus	83-88
2547642-8	1989	Adding amiloride to resting cells caused a slow, reversible acidification (0.04 pH units min-1).	Amiloride	7-16	CD59 molecule (CD59 blood group)	Homo sapiens	89-94
2548914-10	1989	In addition, amiloride inhibited the Nao+ dependency of pHi recovery to a similar degree in F1, F2, and F3 cells.	Amiloride	13-22	glucose-6-phosphate isomerase	Homo sapiens	56-59
2548914-11	1989	Our observations demonstrate in avian granulosa cells the existence of a Nao+-dependent, amiloride-sensitive pHi regulatory system that is equally effective in cells obtained from the three largest yolk-filled follicles.	Amiloride	89-98	glucose-6-phosphate isomerase	Homo sapiens	109-112
2472417-8	1989	The effects of the two drugs amiloride and bumetanide on induction of three genes--c-fos, c-myc, and ornithin decarboxylase (ODC)--was measured during cell transition through the G1-phase.	Amiloride	29-38	ornithine decarboxylase, structural 1	Mus musculus	125-128
2545197-10	1989	Inhibition of the antiport by pharmacological agents such as amiloride, or else by decreasing extracellular Na+, results in a marked decrease of fibrinogen binding to platelets.	Amiloride	61-70	fibrinogen beta chain	Homo sapiens	145-155
2544626-8	1989	The amiloride-independent pHi recovery in +HCO3- was inhibited 50-63% by DIDS and 79% by Na+ replacement but was unaffected by depletion of intracellular Cl-, suggesting that Cl-/HCO3- exchange is not involved.	Amiloride	4-13	glucose-6-phosphate isomerase	Rattus norvegicus	26-29
2543453-1	1989	We studied the effects of epidermal growth factor (EGF), thyroid-stimulating hormone (TSH) and amiloride on cytoplasmic pH (pHi) in cultured porcine thyroid cells.	Amiloride	95-104	glucose-6-phosphate isomerase	Homo sapiens	120-122
2543453-1	1989	We studied the effects of epidermal growth factor (EGF), thyroid-stimulating hormone (TSH) and amiloride on cytoplasmic pH (pHi) in cultured porcine thyroid cells.	Amiloride	95-104	glucose-6-phosphate isomerase	Homo sapiens	124-127
2567705-4	1989	ANF stimulation of cGMP accumulation was specific, in that high concentrations (10(-6)M) of atriopeptin I [rat ANF-(103-123)], angiotensin II, arginine vasopressin, and amiloride (10(-4)M) did not increase basal cGMP.	Amiloride	169-178	natriuretic peptide A	Rattus norvegicus	0-3
2542311-4	1989	In addition, amiloride also attenuated the inhibitory effects of atrial natriuretic factor (ANF 99-126) and angiotensin II on cAMP levels and adenylate cyclase activity.	Amiloride	13-22	natriuretic peptide A	Rattus norvegicus	65-90
2542311-4	1989	In addition, amiloride also attenuated the inhibitory effects of atrial natriuretic factor (ANF 99-126) and angiotensin II on cAMP levels and adenylate cyclase activity.	Amiloride	13-22	angiotensinogen	Rattus norvegicus	92-122
2567705-5	1989	Amiloride (10(-4)M) enhanced (p less than 0.01, n = 6) the ANF stimulation of cGMP accumulation (1.24 +/- 0.39 pmol/mg protein/5 min), particularly at low doses of ANF (10(-10)M) where stimulation by ANF without amiloride (0.34 +/- 0.08 pmol/mg protein/5 min) was barely distinguishable from a basal level (0.19 +/- 0.02 pmol/mg protein/5 min) of cGMP accumulation.	Amiloride	0-9	natriuretic peptide A	Homo sapiens	59-62
2567705-5	1989	Amiloride (10(-4)M) enhanced (p less than 0.01, n = 6) the ANF stimulation of cGMP accumulation (1.24 +/- 0.39 pmol/mg protein/5 min), particularly at low doses of ANF (10(-10)M) where stimulation by ANF without amiloride (0.34 +/- 0.08 pmol/mg protein/5 min) was barely distinguishable from a basal level (0.19 +/- 0.02 pmol/mg protein/5 min) of cGMP accumulation.	Amiloride	0-9	natriuretic peptide A	Homo sapiens	164-167
2550056-3	1989	The 70-kDa fragment bound ANF with enhanced binding affinity but retained intact ANF-R1 pharmacological specificity and was still sensitive to modulation by amiloride.	Amiloride	157-166	natriuretic peptide A	Bos taurus	26-29
2567705-5	1989	Amiloride (10(-4)M) enhanced (p less than 0.01, n = 6) the ANF stimulation of cGMP accumulation (1.24 +/- 0.39 pmol/mg protein/5 min), particularly at low doses of ANF (10(-10)M) where stimulation by ANF without amiloride (0.34 +/- 0.08 pmol/mg protein/5 min) was barely distinguishable from a basal level (0.19 +/- 0.02 pmol/mg protein/5 min) of cGMP accumulation.	Amiloride	0-9	natriuretic peptide A	Homo sapiens	164-167
2567705-5	1989	Amiloride (10(-4)M) enhanced (p less than 0.01, n = 6) the ANF stimulation of cGMP accumulation (1.24 +/- 0.39 pmol/mg protein/5 min), particularly at low doses of ANF (10(-10)M) where stimulation by ANF without amiloride (0.34 +/- 0.08 pmol/mg protein/5 min) was barely distinguishable from a basal level (0.19 +/- 0.02 pmol/mg protein/5 min) of cGMP accumulation.	Amiloride	212-221	natriuretic peptide A	Homo sapiens	59-62
2542756-4	1989	The binding of ANF to this subtype is potentiated by amiloride and by divalent cations.	Amiloride	53-62	natriuretic peptide A	Rattus norvegicus	15-18
2755773-6	1989	In the presence of 10(-3) mol/l amiloride, the response to acetylcholine was a rapid decrease in pHi to 7.02 +/- 0.02.	Amiloride	32-41	glucose-6-phosphate isomerase	Oryctolagus cuniculus	97-100
2471032-9	1989	Amiloride, a blocker of the Na+/H+ exchange (which is known to be activated by PKC in some tissues), did not suppress the effects of PDBu.	Amiloride	0-9	protein kinase C, gamma	Rattus norvegicus	79-82
2542756-10	1989	This subtype recognizes the active forms of ANF as well as its metabolites, and the binding is insensitive to amiloride and is decreased by divalent cations.	Amiloride	110-119	natriuretic peptide A	Rattus norvegicus	44-47
2571140-2	1989	Amiloride increased ANF binding to whole glomeruli and to glomerular membrane preparations.	Amiloride	0-9	natriuretic peptide A	Rattus norvegicus	20-23
2571140-4	1989	These data suggest that under physiological conditions amiloride augments ANF-stimulated intracellular cGMP accumulation.	Amiloride	55-64	natriuretic peptide A	Rattus norvegicus	74-77
2571140-3	1989	In contrast, amiloride enhanced ANF-stimulated cGMP accumulation only at 37 degrees C in whole glomeruli, but not at 4 degrees C in whole glomeruli or at 37 degrees C in membrane preparations.	Amiloride	13-22	natriuretic peptide A	Rattus norvegicus	32-35
2571140-5	1989	The discrepancies between amiloride augmentation of ANF binding and failure to increase ANF-stimulated cGMP accumulation may result from ANF receptor heterogeneity.	Amiloride	26-35	natriuretic peptide A	Rattus norvegicus	52-55
2571140-6	1989	This is the first report of an amiloride augmentation of ANF-stimulated cGMP accumulation in renal tissue.	Amiloride	31-40	natriuretic peptide A	Rattus norvegicus	57-60
2541500-4	1989	Amiloride inhibited the ion fluxes and the accumulation of specific messenger RNA for two genes induced by IFN-gamma (the early gene JE and the beta chain of the class II major histocompatibility complex gene I-A).	Amiloride	0-9	interferon gamma	Mus musculus	107-116
2471189-3	1989	Changes produced by GM-CSF are totally inhibited by amiloride and are significantly reduced in pertussis toxin-treated cells.	Amiloride	52-61	colony stimulating factor 2	Homo sapiens	20-26
2541500-5	1989	The data indicate that IFN-gamma initiates rapid exchange of Na+ and H+ by means of the Na+/H+ antiporter and that these amiloride-sensitive ion fluxes are important to some of the genomic effects of IFN-gamma.	Amiloride	121-130	interferon gamma	Mus musculus	23-32
2541500-5	1989	The data indicate that IFN-gamma initiates rapid exchange of Na+ and H+ by means of the Na+/H+ antiporter and that these amiloride-sensitive ion fluxes are important to some of the genomic effects of IFN-gamma.	Amiloride	121-130	interferon gamma	Mus musculus	200-209
2537850-7	1989	In comparison to WKY cells early passage SHR VSMC exhibited 2.5-fold greater alkalinization and amiloride-sensitive 22Na+ influx in response to 100 nM angiotensin II.	Amiloride	96-105	angiotensinogen	Rattus norvegicus	151-165
2720408-3	1989	Na+/H+ exchange, a mechanism involved in the regulation of intracellular pH (pHi), is activated by low intracellular pH, is dependent on extracellular Na+, and is inhibited by low extracellular pH (pH less than 6) or by amiloride.	Amiloride	220-229	glucose-6-phosphate isomerase	Homo sapiens	77-80
2466856-5	1989	Now, for the first time, we can rigorously address questions concerning the molecular nature of the amiloride block, the channel"s selectivity to alkali metal cations, and the modulation of ion transport through this channel by other ions (such as calcium), hormones (such as vasopressin, aldosterone, and atrial natriuretic factor), or intracellular second messengers (such as cAMP or cGMP).	Amiloride	100-109	arginine vasopressin	Homo sapiens	276-287
2926388-0	1989	Acidosis, acetazolamide, and amiloride: effects on 22Na transfer across the blood-brain and blood-CSF barriers.	Amiloride	29-38	colony stimulating factor 2	Rattus norvegicus	98-101
2926388-4	1989	Like HCl acidosis, amiloride reduced transport into both brain and CSF by 22%.	Amiloride	19-28	colony stimulating factor 2	Rattus norvegicus	67-70
2725018-4	1989	Intracellular pH (pHi) was changed by manipulating the bicarbonate/CO2 ratio of the incubation medium, or by adding amiloride, a hydrogen/sodium antiport blocker.	Amiloride	116-125	glucose-6-phosphate isomerase	Rattus norvegicus	14-16
2725018-4	1989	Intracellular pH (pHi) was changed by manipulating the bicarbonate/CO2 ratio of the incubation medium, or by adding amiloride, a hydrogen/sodium antiport blocker.	Amiloride	116-125	glucose-6-phosphate isomerase	Rattus norvegicus	18-21
2501036-3	1989	Amiloride, an inhibitor of the Na+/H+ antiporter, completely blocked the commitment of TSA8 cells to become responsive to erythropoietin at a concentration that did not affect cell proliferation, while it showed no effect on the differentiation or proliferation of the erythroid progenitor cells derived from TSA8 cells by erythropoietin.	Amiloride	0-9	erythropoietin	Mus musculus	122-136
2501036-3	1989	Amiloride, an inhibitor of the Na+/H+ antiporter, completely blocked the commitment of TSA8 cells to become responsive to erythropoietin at a concentration that did not affect cell proliferation, while it showed no effect on the differentiation or proliferation of the erythroid progenitor cells derived from TSA8 cells by erythropoietin.	Amiloride	0-9	erythropoietin	Mus musculus	323-337
2930591-8	1989	Among these compounds, amiloride and benzamil inhibited Ca2+/CaM-independent MLC phosphorylation due to trypsin-treated MLC kinase.	Amiloride	23-32	myosin, light chain 4, alkali; atrial, embryonic	Gallus gallus	77-80
2930591-8	1989	Among these compounds, amiloride and benzamil inhibited Ca2+/CaM-independent MLC phosphorylation due to trypsin-treated MLC kinase.	Amiloride	23-32	myosin, light chain 4, alkali; atrial, embryonic	Gallus gallus	120-123
2930591-10	1989	These results indicate that amiloride and its analogues inhibit smooth muscle contraction mainly by the direct inhibition of MLC phosphorylation.	Amiloride	28-37	myosin, light chain 4, alkali; atrial, embryonic	Gallus gallus	125-128
2930591-11	1989	The inhibitory effect of amiloride may be attributable to the inhibition of MLC kinase, whereas the inhibitory effect of DEAM and EIAM may largely be attributable to the inhibition of CaM.	Amiloride	25-34	myosin, light chain 4, alkali; atrial, embryonic	Gallus gallus	76-79
2919659-9	1989	The recovery of pHi after the initial acidosis on stimulation with ACh could be blocked by 1 mM amiloride, suggesting that the recovery phase was mediated by Na+-H+ exchange.	Amiloride	96-105	glucose-6-phosphate isomerase	Oryctolagus cuniculus	16-19
2465689-5	1989	In contrast, in both N1 and CF amiloride-pretreated cultures, A23187 induced an increase in the equivalent short-circuit current that was associated with an activation of an apical membrane Gc1- and was bumetanide inhibitable.	Amiloride	31-40	solute carrier family 25 member 22	Homo sapiens	190-193
2536415-1	1989	In various mammalian cell types the stimulation of the plasma membrane amiloride-sensitive Na+/H+ exchange and the resulting increase of intracellular pH (pHi) play a key role in the initiation of cell proliferation.	Amiloride	71-80	glucose-6-phosphate isomerase	Homo sapiens	155-158
2643635-3	1989	Stimulation of renin secretion with prolonged dietary sodium restriction or amiloride resulted in marked increases in the plasma levels of prorenin, active renin, and plasma renin activity (PRA); suppression of renin secretion with indomethacin resulted in parallel decreases in prorenin, active renin, and PRA.	Amiloride	76-85	renin	Homo sapiens	15-20
2643635-3	1989	Stimulation of renin secretion with prolonged dietary sodium restriction or amiloride resulted in marked increases in the plasma levels of prorenin, active renin, and plasma renin activity (PRA); suppression of renin secretion with indomethacin resulted in parallel decreases in prorenin, active renin, and PRA.	Amiloride	76-85	renin	Homo sapiens	142-147
2643635-3	1989	Stimulation of renin secretion with prolonged dietary sodium restriction or amiloride resulted in marked increases in the plasma levels of prorenin, active renin, and plasma renin activity (PRA); suppression of renin secretion with indomethacin resulted in parallel decreases in prorenin, active renin, and PRA.	Amiloride	76-85	renin	Homo sapiens	142-147
2643635-3	1989	Stimulation of renin secretion with prolonged dietary sodium restriction or amiloride resulted in marked increases in the plasma levels of prorenin, active renin, and plasma renin activity (PRA); suppression of renin secretion with indomethacin resulted in parallel decreases in prorenin, active renin, and PRA.	Amiloride	76-85	renin	Homo sapiens	142-147
2643635-3	1989	Stimulation of renin secretion with prolonged dietary sodium restriction or amiloride resulted in marked increases in the plasma levels of prorenin, active renin, and plasma renin activity (PRA); suppression of renin secretion with indomethacin resulted in parallel decreases in prorenin, active renin, and PRA.	Amiloride	76-85	renin	Homo sapiens	142-147
2645305-5	1989	On the other hand, the induction by insulin is sensitive to amiloride, whereas that by arsenite is not.	Amiloride	60-69	insulin	Homo sapiens	36-43
2536240-1	1989	Amiloride-sensitive Na+-H+ exchange has been identified in basolateral membrane vesicles from rat liver, but little is currently known about its regulation or its role in maintenance of resting intracellular pH (pHi) in intact hepatocytes.	Amiloride	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	212-215
2527160-3	1989	This new class of binding sites was recognized by amiloride derivatives; however, it is not likely that these sites are the well-known targets of amiloride in the kidney: the Na+/H+ exchanger and the epithelium Na+ channel.	Amiloride	146-155	solute carrier family 9 member A2	Sus scrofa	175-191
2536240-5	1989	Transient removal of extracellular Na+ or exposure to amiloride reversibly lowered pHi by 0.09 +/- 0.01 and 0.12 +/- 0.03 pH units, respectively, within 5-10 min.	Amiloride	54-63	glucose-6-phosphate isomerase	Rattus norvegicus	83-86
2536240-8	1989	Recovery of pHi after an NH4Cl pulse was reversibly blocked by exposure to amiloride or removal of Na+.	Amiloride	75-84	glucose-6-phosphate isomerase	Rattus norvegicus	12-15
2537620-5	1989	At concentrations of the amiloride analogues which block Na+/H+ exchange in both cell types by 76-98%, the EGF-dependent alterations in [3H]thymidine incorporation or induction in c-myc or c-fos gene transcription were unaltered.	Amiloride	25-34	epidermal growth factor	Homo sapiens	107-110
2537620-5	1989	At concentrations of the amiloride analogues which block Na+/H+ exchange in both cell types by 76-98%, the EGF-dependent alterations in [3H]thymidine incorporation or induction in c-myc or c-fos gene transcription were unaltered.	Amiloride	25-34	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	189-194
2473347-3	1989	The infusion of ANP with amiloride (5 mg/kg + 0.04 mg/kg/min) produced a further increase in natriuresis despite the absence of an increase in RBF and Ccr induced by ANP alone.	Amiloride	25-34	natriuretic peptides A	Oryctolagus cuniculus	16-19
2473334-8	1989	ET-1 also stimulated amiloride-inhibitable Na+/H+ exchange, causing cytosolic alkalinization.	Amiloride	21-30	endothelin 1	Homo sapiens	0-4
2473347-5	1989	However, the pretreatment with amiloride prevented the increase in the urinary excretion of kallikrein and kinins induced by ANP.	Amiloride	31-40	natriuretic peptides A	Oryctolagus cuniculus	125-128
2926354-3	1989	Under experimental conditions, it appears that only about 1% of the amiloride-sensitive influx of Na+ (Ja----b) can be exchanged with NH4+ on an equimolar basis.	Amiloride	68-77	suppressor of cytokine signaling 1	Homo sapiens	103-110
2570337-0	1989	Effect of ATP and amiloride on ANF binding and stimulation of cyclic GMP accumulation in rat glomerular membranes.	Amiloride	18-27	natriuretic peptide A	Rattus norvegicus	31-34
2552203-6	1989	The pHi recovery from acid loading was inhibited by amiloride to about 55% of the control recovery (half-maximal effect at 100 microM).	Amiloride	52-61	glucose-6-phosphate isomerase	Rattus norvegicus	4-7
2552203-9	1989	When PCD cells were treated with 1 mM DCCD, amiloride almost completely inhibited pHi recovery.	Amiloride	44-53	glucose-6-phosphate isomerase	Rattus norvegicus	82-85
2552203-10	1989	Amiloride and the removal of external Na+ had induced a gradual fall in pHi to a new resting value and rapidly recovered when Na+ was added.	Amiloride	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	72-75
2570337-2	1989	Amiloride enhanced high affinity binding of ANF without affecting its stimulation of cGMP.	Amiloride	0-9	natriuretic peptide A	Rattus norvegicus	44-47
2848589-3	1988	Addition of amiloride and 4-acetamide-4"-isothiocyanostilbene-2,2"-disulfonic acid (SITS), which abolish the cytoplasmic alkalinization, inhibited the stimulation of sugar transport by xanthine/xanthine oxidase in the presence of catalase.	Amiloride	12-21	xanthine dehydrogenase	Mus musculus	194-210
2524641-4	1989	The effect of ANP on kallikrein excretion was abolished when amiloride (2.5 mg i.v.)	Amiloride	61-70	natriuretic peptide A	Rattus norvegicus	14-17
2848827-2	1988	The present study shows that acetyltransferase activation and consequent PAF production induced by thrombin in human endothelial cells are markedly inhibited in Na+-free media or after addition of the amiloride analog 5-(N-ethyl-N-isopropyl)amiloride, suggesting that a Na+/H+ antiport system is present in endothelial cells and plays a prominent role in thrombin-induced PAF synthesis.	Amiloride	201-210	coagulation factor II, thrombin	Homo sapiens	99-107
2848827-2	1988	The present study shows that acetyltransferase activation and consequent PAF production induced by thrombin in human endothelial cells are markedly inhibited in Na+-free media or after addition of the amiloride analog 5-(N-ethyl-N-isopropyl)amiloride, suggesting that a Na+/H+ antiport system is present in endothelial cells and plays a prominent role in thrombin-induced PAF synthesis.	Amiloride	201-210	coagulation factor II, thrombin	Homo sapiens	355-363
3060124-2	1988	pHi was rapidly lowered by addition of the sodium salt of a weak acid or by treatment with amiloride.	Amiloride	91-100	glucose-6-phosphate isomerase	Rattus norvegicus	0-3
2848589-3	1988	Addition of amiloride and 4-acetamide-4"-isothiocyanostilbene-2,2"-disulfonic acid (SITS), which abolish the cytoplasmic alkalinization, inhibited the stimulation of sugar transport by xanthine/xanthine oxidase in the presence of catalase.	Amiloride	12-21	catalase	Mus musculus	230-238
3060124-9	1988	A reduction in pHi, either in response to weak acid or amiloride treatment, was associated with a diminution in the rate of efflux of 86Rb+ and of 45Ca2+.	Amiloride	55-64	glucose-6-phosphate isomerase	Rattus norvegicus	15-18
3265891-6	1988	The Na+-H+ exchange inhibitor amiloride (2 mM) slightly reduced pHi recovery rate.	Amiloride	30-39	glucose-6-phosphate isomerase	Homo sapiens	64-67
3265621-5	1988	Evidence is presented that IL-3 can stimulate the activation of an amiloride-sensitive Na+/H+ exchange via protein kinase C activation.	Amiloride	67-76	interleukin 3	Mus musculus	27-31
2853740-0	1988	Amiloride potentiates the vascular effects of atrial natriuretic factor.	Amiloride	0-9	natriuretic peptide A	Rattus norvegicus	46-71
2465413-4	1988	In particular, we observed highly selective, amiloride-sensitive Na channels with a mean conductance of 4.8 pS, channels with a similar conductance that were not Na-selective and channels with mean conductance values of 17-58 pS that were mostly seen after stimulation of the tissue with vasopressin or cAMP.	Amiloride	45-54	arginine vasopressin	Homo sapiens	288-299
2853740-1	1988	We have demonstrated an interaction between the effects of amiloride and atrial natriuretic factor (ANF) on the vascular system.	Amiloride	59-68	natriuretic peptide A	Rattus norvegicus	100-103
2853740-4	1988	In spontaneously hypertensive rats (SHR) ANF-induced decreases in blood pressure were potentiated by amiloride.	Amiloride	101-110	natriuretic peptide A	Rattus norvegicus	41-44
3244157-3	1988	An analysis of passive Na+ fluxes showed a difference in the handling of Na+ via ouabain and bumetanide-insensitive transport between the two cell types: H.Ep.2 cells achieved net Na+ influx via an amiloride-sensitive pathway that was only demonstrated in fibroblasts when 10% fetal calf serum (FCS) was present.	Amiloride	198-207	DNL-type zinc finger	Homo sapiens	154-158
2853740-5	1988	Binding experiments revealed an interaction between amiloride and ANF at the receptor level; binding of labelled ANF to aortic tissue was increased by amiloride but decreased by ATP.	Amiloride	52-61	natriuretic peptide A	Rattus norvegicus	113-116
2853740-5	1988	Binding experiments revealed an interaction between amiloride and ANF at the receptor level; binding of labelled ANF to aortic tissue was increased by amiloride but decreased by ATP.	Amiloride	151-160	natriuretic peptide A	Rattus norvegicus	66-69
2853740-5	1988	Binding experiments revealed an interaction between amiloride and ANF at the receptor level; binding of labelled ANF to aortic tissue was increased by amiloride but decreased by ATP.	Amiloride	151-160	natriuretic peptide A	Rattus norvegicus	113-116
2853740-6	1988	These data show that amiloride and ATP influence a mechanism that determines the sensitivity of vessels to ANF and this interaction occurs both at receptor level and at the level of transduction.	Amiloride	21-30	natriuretic peptide A	Rattus norvegicus	107-110
3254411-15	1988	In HCO3- -free solution pHi recovery was completely blocked when either Na+ was removed or when amiloride was applied indicating an exclusive activation of the Na+-H+ exchanger.	Amiloride	96-105	glucose-6-phosphate isomerase 1	Mus musculus	24-27
2854165-5	1988	In the presence of luminal amiloride (1 mM), the rate of decrease of pHi was significantly less, 0.73 +/- 0.18 pH/min.	Amiloride	27-36	glucose-6-phosphate isomerase	Oryctolagus cuniculus	69-72
2854165-6	1988	Steady-state pHi decreased 0.18 pH units following the addition of amiloride (1 mM) to the lumen (Na+ 140 mM lumen and bath).	Amiloride	67-76	glucose-6-phosphate isomerase	Oryctolagus cuniculus	13-16
2854165-8	1988	The rate of decrease of pHi was significantly less in the presence of 1 mM basolateral amiloride, 0.29 +/- 0.04 pH/min.	Amiloride	87-96	glucose-6-phosphate isomerase	Oryctolagus cuniculus	24-27
2854165-9	1988	Addition of 1 mM amiloride to the basolateral side (Na+ 140 mM lumen and bath) caused steady-state pHi to decrease significantly by 0.06 pH units.	Amiloride	17-26	glucose-6-phosphate isomerase	Oryctolagus cuniculus	99-102
2854165-12	1988	The rate of pHi recovery was inhibited 93% by 1 mM luminal amiloride.	Amiloride	59-68	glucose-6-phosphate isomerase	Oryctolagus cuniculus	12-15
2854165-14	1988	Addition of 1 mM basolateral amiloride inhibited the recovery of pHi by 97%.	Amiloride	29-38	glucose-6-phosphate isomerase	Oryctolagus cuniculus	65-68
3218971-1	1988	The diuretic Amiloride competitively inhibits the catalytic activity of the urokinase-type plasminogen activator on plasminogen in vitro.	Amiloride	13-22	plasminogen activator, urokinase	Rattus norvegicus	76-112
2846205-1	1988	This highly sensitive radioreceptor assay (RRA) for the active circulating form of atrial natriuretic factor (ANF), fragment 99-126, in human plasma requires 125I-labeled ANF, bovine zona-glomerulosa membrane receptors, and amiloride HCl.	Amiloride	224-237	natriuretic peptide A	Homo sapiens	83-108
2846205-1	1988	This highly sensitive radioreceptor assay (RRA) for the active circulating form of atrial natriuretic factor (ANF), fragment 99-126, in human plasma requires 125I-labeled ANF, bovine zona-glomerulosa membrane receptors, and amiloride HCl.	Amiloride	224-237	natriuretic peptide A	Homo sapiens	110-113
2846205-2	1988	The amiloride elicits an increase in the binding affinity of ANF to its receptors.	Amiloride	4-13	natriuretic peptide A	Homo sapiens	61-64
2852953-9	1988	Finally, the purified ANF-R1 receptor retained its sensitivity to modulation by amiloride, suggesting the presence of an allosteric binding site for amiloride on the receptor protein.	Amiloride	80-89	natriuretic peptide A	Bos taurus	22-25
2852953-9	1988	Finally, the purified ANF-R1 receptor retained its sensitivity to modulation by amiloride, suggesting the presence of an allosteric binding site for amiloride on the receptor protein.	Amiloride	149-158	natriuretic peptide A	Bos taurus	22-25
2844756-5	1988	We also demonstrate that CSF-1 stimulates Na+ influx into monocytes by an amiloride-sensitive mechanism, presumably the Na+/H+ antiport.	Amiloride	74-83	colony stimulating factor 1	Homo sapiens	25-30
2843345-6	1988	This is further supported by the observation that pHi decreased to 6.70 +/- 0.01 when amiloride, an inhibitor of Na+/H+ exchange, was added, and that this agent prevented the recovery of pHi in Na+-depleted cells after addition of Na+ to the medium.	Amiloride	86-95	glucose-6-phosphate isomerase	Rattus norvegicus	50-53
2843345-6	1988	This is further supported by the observation that pHi decreased to 6.70 +/- 0.01 when amiloride, an inhibitor of Na+/H+ exchange, was added, and that this agent prevented the recovery of pHi in Na+-depleted cells after addition of Na+ to the medium.	Amiloride	86-95	glucose-6-phosphate isomerase	Rattus norvegicus	187-190
3236318-3	1988	Amiloride 5 mg once daily significantly reduced supine and standing DBP but not SBP (supine 151/94, standing 149/97 mmHg), whereas 10 mg once daily decreased SBP as well as DBP (supine 145/98, standing 145/101 mmHg).	Amiloride	0-9	D-box binding PAR bZIP transcription factor	Homo sapiens	68-71
3236318-6	1988	Plasma noradrenaline was unaltered following amiloride 10 mg once daily as well as nitrendipine 20 mg twice daily, whereas plasma renin activity and aldosterone were elevated following amiloride.	Amiloride	185-194	renin	Homo sapiens	130-135
2852254-3	1988	Thorough studies of the Na+ channel, the Na+/H+ exchanger, and the Na+/Ca2+ exchanger, clearly show that appropriate modification of the structure of amiloride will generate analogs with increased affinity and specificity for a particular transport system.	Amiloride	150-159	solute carrier family 8 member A1	Homo sapiens	67-85
2844182-6	1988	The induction of ornithine decarboxylase by L-asparagine was also amiloride-sensitive.	Amiloride	66-75	ornithine decarboxylase 1	Rattus norvegicus	17-40
2458679-4	1988	The IGF1 response is inhibited by a concentration of amiloride (10(-5) M) that is known to specifically block the conductive apical Na+ channel but that has little effect on the Na+-H+ antiporter.	Amiloride	53-62	insulin like growth factor 1	Homo sapiens	4-8
2843231-7	1988	There was a dose-dependent inhibition of pHi recovery after NH4Cl prepulse by amiloride with an IC50 of about 15 microM.	Amiloride	78-87	glucose-6-phosphate isomerase	Oryctolagus cuniculus	41-44
2843231-8	1988	Amiloride in a concentration of 1 mM almost completely abolished pHi recovery.	Amiloride	0-9	glucose-6-phosphate isomerase	Oryctolagus cuniculus	65-68
2852509-0	1988	Amiloride and its analogs as tools to inhibit Na+ transport via the Na+ channel, the Na+/H+ antiport and the Na+/Ca2+ exchanger.	Amiloride	0-9	solute carrier family 8 member A1	Homo sapiens	109-127
3262122-4	1988	EGF produced a rapid increase in intracellular pH of 0.12 +/- 0.01 pH U, which was sodium dependent and amiloride inhibitable.	Amiloride	104-113	epidermal growth factor like 1	Rattus norvegicus	0-3
3225554-7	1988	Amiloride (1-2 mM) inhibited the pHi recovery that was elicited by returning 15 or 29 mM Na+ to lumen by only approximately 30%.	Amiloride	0-9	glucose-6-phosphate isomerase	Oryctolagus cuniculus	33-36
3225554-8	1988	However, in the absence of external acetate (Ac-), 1 mM amiloride inhibited approximately 66% of the pHi recovery induced by the readdition of 29 mM Na+ to the lumen only.	Amiloride	56-65	glucose-6-phosphate isomerase	Oryctolagus cuniculus	101-104
2842350-2	1988	4 beta-PDD or serum induced a rapid increase in pHi, and antioxidants such as superoxide dismutase (SOD), vitamin E, and butylated hydroxyanisole (BHA) were found to inhibit the amiloride-sensitive increase in pHi induced by 4 beta-PDD.	Amiloride	178-187	glucose-6-phosphate isomerase	Homo sapiens	48-51
2842350-2	1988	4 beta-PDD or serum induced a rapid increase in pHi, and antioxidants such as superoxide dismutase (SOD), vitamin E, and butylated hydroxyanisole (BHA) were found to inhibit the amiloride-sensitive increase in pHi induced by 4 beta-PDD.	Amiloride	178-187	superoxide dismutase 1	Homo sapiens	78-98
2842350-2	1988	4 beta-PDD or serum induced a rapid increase in pHi, and antioxidants such as superoxide dismutase (SOD), vitamin E, and butylated hydroxyanisole (BHA) were found to inhibit the amiloride-sensitive increase in pHi induced by 4 beta-PDD.	Amiloride	178-187	superoxide dismutase 1	Homo sapiens	100-103
2842350-2	1988	4 beta-PDD or serum induced a rapid increase in pHi, and antioxidants such as superoxide dismutase (SOD), vitamin E, and butylated hydroxyanisole (BHA) were found to inhibit the amiloride-sensitive increase in pHi induced by 4 beta-PDD.	Amiloride	178-187	glucose-6-phosphate isomerase	Homo sapiens	210-213
3412774-4	1988	When 3T3 cells are heat shocked in the presence of amiloride, an inhibitor of Na+/H+ exchange, the induction of c-fos mRNA is partially inhibited, whereas that of hsp70 is somewhat enhanced.	Amiloride	51-60	FBJ osteosarcoma oncogene	Mus musculus	112-117
3412774-4	1988	When 3T3 cells are heat shocked in the presence of amiloride, an inhibitor of Na+/H+ exchange, the induction of c-fos mRNA is partially inhibited, whereas that of hsp70 is somewhat enhanced.	Amiloride	51-60	heat shock protein 1B	Mus musculus	163-168
3260251-8	1988	In medium lacking sodium bicarbonate the intracellular alkalinization via the CD2 structure could be blocked by the amiloride analogue 5-(N-methyl-N-isobutyl)amiloride (MIA), which indicates that this increase in pH is mediated by the amiloride-sensitive Na+/H+ antiporter.	Amiloride	116-125	CD2 molecule	Homo sapiens	78-81
2839040-3	1988	Preliminary studies, using the pH-sensitive fluorescent probe 2",7"-bis(2-carboxyethyl)-5(6)-carboxyfluorescein indicated that these cells regulate pHi by means of an amiloride-inhibitable Na+-H+ exchanger.	Amiloride	167-176	glucose-6-phosphate isomerase	Rattus norvegicus	148-151
2839040-8	1988	However, rPTH remained a potent inhibitor of [3H]thymidine incorporation in the presence of amiloride, even though it did not affect pHi in these circumstances.	Amiloride	92-101	parathyroid hormone	Rattus norvegicus	9-13
3165095-10	1988	A sensitizing effect was noted with amiloride or cytochalasin B, characterized by greater relative increases of [3H]TdR incorporation and TdR kinase activity in response to TNF.	Amiloride	36-45	tumor necrosis factor	Homo sapiens	173-176
3076778-3	1988	Amiloride also caused a rapid fall in pHi, but no recovery occurred in this case.	Amiloride	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	38-41
3184169-3	1988	Following an acid load imposed by a NH4Cl prepulse, pHi was regulated in the absence of HCO3- by a Na+-dependent process inhibitable to a large extent by 1 mM amiloride and 0.1 mM dimethylamiloride.	Amiloride	159-168	glucose-6-phosphate isomerase	Bos taurus	52-55
3174385-3	1988	(3) pHi-Recovery after an acute intracellular acid load (by means of NH4Cl-prepulse) was reversibly blocked by 1 mM amiloride and was dependent on the presence of sodium.	Amiloride	116-125	glucose-6-phosphate isomerase	Homo sapiens	4-7
2454030-1	1988	Incubating toad bladder with 10 mU/ml vasopressin increases the amiloride-blockable Na+ flux in membrane vesicles derived from the epithelial cells by about twofold.	Amiloride	64-73	arginine vasopressin	Homo sapiens	38-49
2837093-4	1988	Although amiloride inhibited the angiotensin II- and adrenocorticotropic hormone (ACTH)-induced aldosterone response, HMA, a more specific inhibitor of Na+-H+ exchange, failed to do that.	Amiloride	9-18	angiotensinogen	Rattus norvegicus	33-47
2837094-4	1988	ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+.	Amiloride	18-27	angiotensinogen	Rattus norvegicus	0-6
2837094-4	1988	ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+.	Amiloride	18-27	glucose-6-phosphate isomerase	Rattus norvegicus	111-114
2837094-4	1988	ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+.	Amiloride	18-27	glucose-6-phosphate isomerase	Rattus norvegicus	140-143
2837094-4	1988	ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+.	Amiloride	18-27	angiotensinogen	Rattus norvegicus	201-207
2837094-4	1988	ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+.	Amiloride	18-27	angiotensinogen	Rattus norvegicus	201-207
2837094-4	1988	ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+.	Amiloride	156-165	angiotensinogen	Rattus norvegicus	0-6
2837094-4	1988	ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+.	Amiloride	156-165	glucose-6-phosphate isomerase	Rattus norvegicus	111-114
2837094-4	1988	ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+.	Amiloride	156-165	glucose-6-phosphate isomerase	Rattus norvegicus	140-143
2837094-4	1988	ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+.	Amiloride	156-165	angiotensinogen	Rattus norvegicus	201-207
2837094-4	1988	ANG II-stimulated amiloride-sensitive Na+ influx for up to 30 min with a half-maximal activation 10(-8) M. The pHi dependence from cell pH (pHi 7.2-6.2) of amiloride-sensitive Na+ influx stimulated by ANG II was similar to that of the basal values, a finding indicating that ANG II did not change the affinity of Na+-H+ exchange for intracellular H+.	Amiloride	156-165	angiotensinogen	Rattus norvegicus	201-207
2837094-5	1988	However, at pHi 6.8, ANG II increased the Vmax of amiloride-sensitive Na+ influx from 25 to 33 nmol.mg protein-1.min-1 and markedly decreased the Km for Na+o from 23.6 +/- 7.4 to 3.7 (SD, n = 4; P less than 0.005) mM.	Amiloride	50-59	glucose-6-phosphate isomerase	Rattus norvegicus	12-15
2837094-5	1988	However, at pHi 6.8, ANG II increased the Vmax of amiloride-sensitive Na+ influx from 25 to 33 nmol.mg protein-1.min-1 and markedly decreased the Km for Na+o from 23.6 +/- 7.4 to 3.7 (SD, n = 4; P less than 0.005) mM.	Amiloride	50-59	angiotensinogen	Rattus norvegicus	21-27
3381882-4	1988	The pHi recovery following an NH+4-induced acid load was inhibited by removal of Na+ from the bath or by addition of the amiloride analogue, ethyl isopropyl amiloride (EIPA).	Amiloride	121-130	glucose-6-phosphate isomerase	Rattus norvegicus	4-7
2841075-9	1988	Application of 1 mM amiloride reversibly inhibited pHi recovery.	Amiloride	20-29	glucose-6-phosphate isomerase	Bos taurus	51-54
2835373-4	1988	Amiloride inhibited the rIFN-gamma-mediated pH rise by only 31% at 30 min, but at 4 h the inhibition was more complete (89%).	Amiloride	0-9	interferon gamma	Rattus norvegicus	24-34
2454102-0	1988	Amiloride increases the sensitivity of particulate guanylate cyclase to atrial natriuretic factor.	Amiloride	0-9	natriuretic peptide A	Homo sapiens	72-97
2454102-1	1988	The natriuretic agent amiloride induces a shift of the dose-response curve of particulate guanylate cyclase to atrial natriuretic factor (ANF) to the left.	Amiloride	22-31	natriuretic peptide A	Homo sapiens	111-136
2454102-1	1988	The natriuretic agent amiloride induces a shift of the dose-response curve of particulate guanylate cyclase to atrial natriuretic factor (ANF) to the left.	Amiloride	22-31	natriuretic peptide A	Homo sapiens	138-141
2454102-2	1988	The ANF concentration for half-maximal activation of guanylate cyclase is shifted from 20 to 3 nM in the presence of 100 microM amiloride.	Amiloride	128-137	natriuretic peptide A	Homo sapiens	4-7
2454102-5	1988	These data suggest that some of the effects of amiloride may be mediated by an increased sensitivity of particulate guanylate cyclase to ANF.	Amiloride	47-56	natriuretic peptide A	Homo sapiens	137-140
2833347-9	1988	The functions of the Na+/K+ and Na+/H+ exchange systems are apparently necessary for the enhanced A system activity, since ouabain and amiloride can inhibit the uptake of [3H]methylaminoisobutyric acid in K-NRK cells and in NRK cells treated with TGF-alpha and/or -beta.	Amiloride	135-144	transforming growth factor alpha	Rattus norvegicus	247-256
2970886-0	1988	Interaction of amiloride and hydrochlorothiazide with atrial natriuretic factor in the medullary collecting duct.	Amiloride	15-24	natriuretic peptide A	Rattus norvegicus	54-79
2848042-5	1988	In the presence of 1 mM amiloride or in the absence of Na+, this process was blocked, indicating the involvement of an Na+/H+ exchanger in the regulation of pHi after an acid load.	Amiloride	24-33	glucose-6-phosphate isomerase	Bos taurus	157-160
3169488-6	1988	Removal of Na+ from and addition of amiloride to the serosal perfusate during exposure to serosal pH 6.0 induced further acidification of pHi, suggesting that in this acidotic situation (with very low ambient HCO3- concentration) a Na+/H+ exchanger does contribute to the maintenance of steady-state pHi.	Amiloride	36-45	glucose-6-phosphate isomerase	Homo sapiens	98-100
3169488-6	1988	Removal of Na+ from and addition of amiloride to the serosal perfusate during exposure to serosal pH 6.0 induced further acidification of pHi, suggesting that in this acidotic situation (with very low ambient HCO3- concentration) a Na+/H+ exchanger does contribute to the maintenance of steady-state pHi.	Amiloride	36-45	glucose-6-phosphate isomerase	Homo sapiens	138-141
3169488-6	1988	Removal of Na+ from and addition of amiloride to the serosal perfusate during exposure to serosal pH 6.0 induced further acidification of pHi, suggesting that in this acidotic situation (with very low ambient HCO3- concentration) a Na+/H+ exchanger does contribute to the maintenance of steady-state pHi.	Amiloride	36-45	glucose-6-phosphate isomerase	Homo sapiens	300-303
2970886-5	1988	Atrial natriuretic factor reduced collecting duct sodium reabsorption when added to amiloride or hydrochlorothiazide to 23% and to 41%, respectively, but had no additional effect when given with amiloride and hydrochlorothiazide.	Amiloride	84-93	natriuretic peptide A	Rattus norvegicus	0-25
2833308-5	1988	Amiloride (0.1 mM) inhibited the sodium-induced increase in pHi.	Amiloride	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	60-63
2842906-3	1988	The Con A- and TPA-induced rise of pHi is due to activation of Na+/H+ exchange since it was abolished by amiloride, an inhibitor of Na+/H+ antiport, or in a low-Na+ medium.	Amiloride	105-114	glucose-6-phosphate isomerase	Rattus norvegicus	35-38
2833308-11	1988	We conclude that pHi regulation in rat alveolar type II cells is in part mediated by an amiloride-sensitive Na+/H+ antiporter, but this system appears not to be involved in TPA- or terbutaline-induced pulmonary surfactant secretion in primary culture.	Amiloride	88-97	glucose-6-phosphate isomerase	Rattus norvegicus	17-20
2965516-1	1988	To examine whether amiloride, an inhibitor of a conductive sodium channel in the distal tubule, modifies a possible tubular action of atrial natriuretic peptide (ANP), alpha-human ANP (0.05 micrograms.kg-1.min-1) was infused intravenously with or without pretreatment of amiloride (5 mg/kg + 0.04 mg.kg-1.min-1) in anesthetized rabbits.	Amiloride	19-28	natriuretic peptide A	Homo sapiens	134-160
2449893-8	1988	We conclude that the vasorelaxant effects of amiloride are mediated via inhibition of myosin light chain kinase and protein kinase C, in addition to the inhibition of Ca2+ influx.	Amiloride	45-54	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	86-111
3348797-0	1988	Amiloride sensitive activation of S6 kinase by angiotensin II in cultured vascular smooth muscle cells.	Amiloride	0-9	angiotensinogen	Homo sapiens	47-61
3348406-0	1988	Amiloride inhibits rat mucosal ornithine decarboxylase activity and DNA synthesis.	Amiloride	0-9	ornithine decarboxylase 1	Rattus norvegicus	31-54
3348406-5	1988	In the jejunum, but not the liver, the activation of ODC was completely abolished by 100 mg/kg amiloride.	Amiloride	95-104	ornithine decarboxylase 1	Rattus norvegicus	53-56
3348406-8	1988	In conclusion, amiloride inhibits the postprandial increases in jejunal ODC activity and DNA synthesis in the jejunum and liver.	Amiloride	15-24	ornithine decarboxylase 1	Rattus norvegicus	72-75
3348406-9	1988	The results indicate that 1) the Na+-H+ antiport is essential to the increased ODC activity in the jejunum and the stimulation of DNA synthesis in the jejunum and liver after a meal and 2) increases in DNA synthesis and their suppression by amiloride are not necessarily linked to ODC activity.	Amiloride	241-250	ornithine decarboxylase 1	Rattus norvegicus	79-82
3286321-9	1988	PGE2 and Cu/PGE2 stimulation of LHRH release were both inhibited when Na+ was substituted with Li+, or when 0.5 mM ouabain was included in the Na+-containing buffer; neither 10 microM tetrodotoxin (TTX) nor 100 microM amiloride were inhibitory.	Amiloride	218-227	gonadotropin releasing hormone 1	Rattus norvegicus	32-36
3348797-3	1988	However, stimulation of S6-kinase activity by angiotensin II was markedly inhibited by the inclusion of amiloride hydrochloride in serum-free medium during activation procedures.	Amiloride	104-127	angiotensinogen	Homo sapiens	46-60
2452306-7	1988	Amiloride (10(-3) M) and verapamil (10(-5) M) abolished the AII induced increase in kei.	Amiloride	0-9	angiotensinogen	Rattus norvegicus	60-63
2452306-8	1988	These findings are consistent with angiotensin II stimulation of an amiloride-sensitive Na+ transport, which is likely to represent the Na+/H+ antiport.	Amiloride	68-77	angiotensinogen	Rattus norvegicus	35-49
3288050-7	1988	Since amiloride and its analogues blocked endothelium-dependent relaxations in different arterial preparations, Na+ transport and Na+/Ca2+ exchange were suggested to play a role in calcium-dependent release of EDRF.	Amiloride	6-15	alpha hemoglobin stabilizing protein	Homo sapiens	210-214
2828086-3	1988	In addition pHi is shown to be most sensitive to the diuretic amiloride in the G1/S-phase transition, in agreement with the ion influx data.	Amiloride	62-71	glucose-6-phosphate isomerase	Homo sapiens	12-15
2835488-6	1988	In the presence of amiloride (0.1 mM) or the absence of Na+, application of ACh caused a significant decrease in pHi and removal of amiloride or replacement with Na+-containing saline, respectively, rapidly increased the pHi.	Amiloride	19-28	glucose-6-phosphate isomerase 1	Mus musculus	113-116
3422134-10	1988	However, we did find that the amiloride analogue phenamil reversibly inhibits dimethyl sulfoxide (DMSO)-induced MEL cell commitment to differentiate with a K1/2 of 2.5-5.0 microM (in plasma clot assay).	Amiloride	30-39	keratin 1	Mus musculus	156-165
2447799-1	1988	The effect of cholecystokinin (CCK)-gastrin family peptides (caerulein, unsulfated gastrin-17, and pentagastrin) and secretin in activating amiloride-sensitive 22Na uptake were investigated in guinea pig pancreatic acini.	Amiloride	140-149	cholecystokinin	Cavia porcellus	31-34
2447799-1	1988	The effect of cholecystokinin (CCK)-gastrin family peptides (caerulein, unsulfated gastrin-17, and pentagastrin) and secretin in activating amiloride-sensitive 22Na uptake were investigated in guinea pig pancreatic acini.	Amiloride	140-149	gastrin	Cavia porcellus	36-43
2447799-1	1988	The effect of cholecystokinin (CCK)-gastrin family peptides (caerulein, unsulfated gastrin-17, and pentagastrin) and secretin in activating amiloride-sensitive 22Na uptake were investigated in guinea pig pancreatic acini.	Amiloride	140-149	gastrin	Cavia porcellus	83-90
2447799-2	1988	Secretin had no effect, but CCK-gastrin peptides stimulated the amiloride-sensitive 22Na uptake.	Amiloride	64-73	cholecystokinin	Cavia porcellus	28-31
2447799-2	1988	Secretin had no effect, but CCK-gastrin peptides stimulated the amiloride-sensitive 22Na uptake.	Amiloride	64-73	gastrin	Cavia porcellus	32-39
3257228-3	1988	This decrease in pHi was magnified in Na+-free medium or in the presence of amiloride analogues, suggesting that activation of Na+/H+ exchange partially counteracts the phytohemagglutinin-induced acidification.	Amiloride	76-85	glucose-6-phosphate isomerase	Homo sapiens	17-20
2835488-6	1988	In the presence of amiloride (0.1 mM) or the absence of Na+, application of ACh caused a significant decrease in pHi and removal of amiloride or replacement with Na+-containing saline, respectively, rapidly increased the pHi.	Amiloride	132-141	glucose-6-phosphate isomerase 1	Mus musculus	221-224
3354650-7	1988	The influx of Li+, as well as the increase in pHi in 140 mM Li+ medium, was competitively inhibited by amiloride (Ki approximately equal to 9 microM).	Amiloride	103-112	glucose-6-phosphate isomerase	Homo sapiens	46-49
2835488-6	1988	In the presence of amiloride (0.1 mM) or the absence of Na+, application of ACh caused a significant decrease in pHi and removal of amiloride or replacement with Na+-containing saline, respectively, rapidly increased the pHi.	Amiloride	19-28	glucose-6-phosphate isomerase 1	Mus musculus	221-224
2825538-4	1987	The Na+-dependent rise in pHi was blocked by high concentrations of amiloride, but was not affected by alterations in membrane potential across the cell.	Amiloride	68-77	glucose-6-phosphate isomerase	Rattus norvegicus	26-29
3367375-4	1988	After myocytes were acid-loaded with NH4Cl, the pHi recovered from acidosis to the resting level within a few minutes via amiloride-sensitive Na+/H+ exchange.	Amiloride	122-131	glucose-6-phosphate isomerase 1	Mus musculus	48-51
3367375-6	1988	The inhibition of the pHi recovery from acidosis by ouabain is possibly caused by an inhibition of amiloride-sensitive Na+/H+ exchange, which is secondary to a suppression of Na+ efflux through (Na+, K+) pump.	Amiloride	99-108	glucose-6-phosphate isomerase 1	Mus musculus	22-25
2826152-5	1987	The zymosan and phorbol-ester-stimulated release of prostaglandins E2 and D2 was inhibited by amiloride.	Amiloride	94-103	dihydrolipoamide S-succinyltransferase	Rattus norvegicus	67-76
3676349-8	1987	In the presence of 1 mM amiloride, an inhibitor of the Na+/H+ exchanger, the steady-state pHi did not change significantly.	Amiloride	24-33	vasoactive intestinal peptide	Sus scrofa	90-93
2832823-3	1988	(1) Regulation of pHi after induction of an acid load by removal of NH4Cl could be blocked either totally by removal of extracellular sodium, or subtotally (about 90%) by application of amiloride (1 mmol/l).	Amiloride	186-195	glucose-6-phosphate isomerase	Bos taurus	18-21
3427448-6	1987	Both pHi recovery and cell swelling were Na+-dependent, amiloride-sensitive, and inhibited at pHo less than 6.0.	Amiloride	56-65	glucose-6-phosphate isomerase	Homo sapiens	5-8
3314489-11	1987	The action of amiloride on ADH-mediated water transport seems specific in as much as it is capable of preventing the uptake of lithium in high resistance epithelia and thereby prevents the inhibitory effect of intracellular lithium on water transport.	Amiloride	14-23	arginine vasopressin	Homo sapiens	27-30
2826642-0	1987	A derivative of amiloride blocks both the light-regulated and cyclic GMP-regulated conductances in rod photoreceptors.	Amiloride	16-25	5'-nucleotidase, cytosolic II	Homo sapiens	69-72
2890352-11	1987	In all systems, amiloride inhibited specific ligand binding concentration-dependently, the Ki values for amiloride were about 25, 52, 148 and 161 microM for alpha 1- alpha 2-, beta 1- and beta 2-adrenoceptor subtypes, respectively.	Amiloride	16-25	adrenoceptor beta 1	Rattus norvegicus	157-207
2820995-3	1987	Thrombin (0.4 unit/ml) caused a rapid cell acidification followed by a slow, amiloride-inhibitable alkalinization (0.10-0.14 delta pHi above base line).	Amiloride	77-86	coagulation factor II, thrombin	Homo sapiens	0-8
2890352-11	1987	In all systems, amiloride inhibited specific ligand binding concentration-dependently, the Ki values for amiloride were about 25, 52, 148 and 161 microM for alpha 1- alpha 2-, beta 1- and beta 2-adrenoceptor subtypes, respectively.	Amiloride	105-114	adrenoceptor beta 1	Rattus norvegicus	157-207
2443144-0	1987	Amiloride inhibits the protein tyrosine kinases associated with the cellular and the transforming src-gene products.	Amiloride	0-9	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	98-101
2820700-0	1987	Identification of amiloride-sensitive Na+/H+ exchange in rat NB2 node lymphoma cells.	Amiloride	18-27	contactin 5	Rattus norvegicus	61-64
2820701-0	1987	Amiloride-sensitive Na+/H+ exchange in rat NB2 node lymphoma cells.	Amiloride	0-9	contactin 5	Rattus norvegicus	43-46
2820701-2	1987	Human PRL (hPRL) stimulated an amiloride-sensitive Na+/H+ exchange system, measured as extracellular acidification or rate of H+ efflux, uptake of 22Na+, and intracellular alkalinization (pHi) in rat Nb2 node lymphoma cells.	Amiloride	31-40	prolactin	Rattus norvegicus	6-9
2820701-2	1987	Human PRL (hPRL) stimulated an amiloride-sensitive Na+/H+ exchange system, measured as extracellular acidification or rate of H+ efflux, uptake of 22Na+, and intracellular alkalinization (pHi) in rat Nb2 node lymphoma cells.	Amiloride	31-40	prolactin	Homo sapiens	11-15
2820701-2	1987	Human PRL (hPRL) stimulated an amiloride-sensitive Na+/H+ exchange system, measured as extracellular acidification or rate of H+ efflux, uptake of 22Na+, and intracellular alkalinization (pHi) in rat Nb2 node lymphoma cells.	Amiloride	31-40	contactin 5	Rattus norvegicus	200-203
2888787-5	1987	The decrease in pHi was inhibited 62% by 1 mM amiloride (lumen) and was unaffected by 50 microM 4,4"-diisothiocyanostilbene-2,2"-disulfonic acid (lumen) and Cl- removal (lumen, bath).	Amiloride	46-55	glucose-6-phosphate isomerase	Oryctolagus cuniculus	16-19
3443939-4	1987	The Na+o-stimulated Mg2+ outflow is sensitive to millimolar amiloride concentrations.	Amiloride	60-69	mucin 7, secreted	Homo sapiens	20-23
2445661-0	1987	Amiloride-induced suppression of lymphocyte proliferation: inhibition of IL 2 receptor expression after blockade of early sodium influx.	Amiloride	0-9	interleukin 2 receptor subunit beta	Homo sapiens	73-86
2445661-4	1987	We have studied the mechanism whereby amiloride inhibits the blastogenesis by measuring their effect on: 1) IL 2 production, 2) acquisition of IL 2 responsiveness and induction of IL 2 receptors, 3) IL 2-induced proliferation.	Amiloride	38-47	interleukin 2	Homo sapiens	108-112
2445661-4	1987	We have studied the mechanism whereby amiloride inhibits the blastogenesis by measuring their effect on: 1) IL 2 production, 2) acquisition of IL 2 responsiveness and induction of IL 2 receptors, 3) IL 2-induced proliferation.	Amiloride	38-47	interleukin 2	Homo sapiens	143-147
2445661-4	1987	We have studied the mechanism whereby amiloride inhibits the blastogenesis by measuring their effect on: 1) IL 2 production, 2) acquisition of IL 2 responsiveness and induction of IL 2 receptors, 3) IL 2-induced proliferation.	Amiloride	38-47	interleukin 2	Homo sapiens	143-147
2445661-4	1987	We have studied the mechanism whereby amiloride inhibits the blastogenesis by measuring their effect on: 1) IL 2 production, 2) acquisition of IL 2 responsiveness and induction of IL 2 receptors, 3) IL 2-induced proliferation.	Amiloride	38-47	interleukin 2	Homo sapiens	143-147
2445661-7	1987	These results show that the drugs interact differently with the different cell populations involved in T cell proliferation: increase of an amiloride-dependent sodium influx is an obligatory step required to induce the early increase of the ouabain-dependent potassium influx which is needed for the expression of IL 2 receptors.	Amiloride	140-149	interleukin 2	Homo sapiens	314-318
3630723-0	1987	The effect of amiloride on biliary HCO3- secretion in the anaesthetized pig.	Amiloride	14-23	HCO3	Sus scrofa	35-39
3038873-0	1987	Functional heterogeneity of atrial natriuretic factor receptor in bovine adrenal zona glomerulosa is explained by an amiloride-sensitive high affinity molecular complex.	Amiloride	117-126	natriuretic peptide A	Bos taurus	28-53
3038873-1	1987	The effects of amiloride on the molecular characteristics of the atrial natriuretic factor (ANF) receptor from bovine adrenal zona glomerulosa were studied by computer modeling of competitive binding data, by affinity labeling experiments, and by steric exclusion high performance liquid chromatography of solubilized receptor.	Amiloride	15-24	natriuretic peptide A	Bos taurus	65-90
3038873-1	1987	The effects of amiloride on the molecular characteristics of the atrial natriuretic factor (ANF) receptor from bovine adrenal zona glomerulosa were studied by computer modeling of competitive binding data, by affinity labeling experiments, and by steric exclusion high performance liquid chromatography of solubilized receptor.	Amiloride	15-24	natriuretic peptide A	Bos taurus	92-95
3038873-4	1987	Computer analysis of competition curves revealed that all ANF analogs tested show similar binding characteristics: shallow competition curves, discrimination of varying proportions of high and low affinity binding states, and sensitivity to amiloride which increases the proportion of the high affinity binding component.	Amiloride	241-250	natriuretic peptide A	Bos taurus	58-61
3036868-4	1987	In both cell types, recovery of pHi from an NH+4-induced acid load follows an exponential time course and is entirely mediated by the amiloride-sensitive Na+/H+ exchanger in the plasma membrane.	Amiloride	134-143	glucose-6-phosphate isomerase	Homo sapiens	32-35
3036868-6	1987	The Na+/H+ exchanger of MES-1 cells is responsive to epidermal growth factor, platelet-derived growth factor, serum, phorbol esters, and diacylglycerol, as shown by a rapid amiloride-sensitive rise in pHi of 0.15-0.35 unit.	Amiloride	173-182	glucose-6-phosphate isomerase	Homo sapiens	201-204
3040779-1	1987	Chinese hamster embryo fibroblast cells (CHEF/18) possess a plasma membrane-associated, amiloride-sensitive Na+/H+ antiporter that affects intracellular pH (pHi) and is activated by growth factor addition.	Amiloride	88-97	glucose-6-phosphate isomerase	Cricetulus griseus	157-160
3630723-6	1987	We found that amiloride (2.0 X 10(-4) mol l-1 plasma) reduced UDCA-dependent canalicular HCO3- secretion by 26 (14-35)% without concurrently reducing bile acid secretion.	Amiloride	14-23	HCO3	Sus scrofa	89-93
3036978-6	1987	Our results demonstrate that amiloride inhibits superoxide anion production by FMLP, A23187, and opsonized zymosan by causing a slower rate of release and lower maximal release without altering lag time.	Amiloride	29-38	formyl peptide receptor 1	Homo sapiens	79-83
3037913-9	1987	It was also found that changing from NMG gluconate to Na gluconate Ringer caused pHi to increase from 7.1 to 7.3, and this alkalinization was blocked by 10(-3) M amiloride; changing from NMG gluconate to NMG Cl Ringer caused pHi to decrease to 6.7.	Amiloride	162-171	glucose-6-phosphate isomerase	Oryctolagus cuniculus	81-84
3037913-9	1987	It was also found that changing from NMG gluconate to Na gluconate Ringer caused pHi to increase from 7.1 to 7.3, and this alkalinization was blocked by 10(-3) M amiloride; changing from NMG gluconate to NMG Cl Ringer caused pHi to decrease to 6.7.	Amiloride	162-171	glucose-6-phosphate isomerase	Oryctolagus cuniculus	225-228
3036978-9	1987	These data suggest that PMN superoxide release induced by FMLP, A23187, and opsonized zymosan is likely modulated by amiloride-sensitive Na+-H+ exchange; and phorbol ester-induced superoxide anion release and degranulation by any stimulant do not appear to be modulated by inhibition of an amiloride-sensitive Na+-H+ exchange.	Amiloride	117-126	formyl peptide receptor 1	Homo sapiens	58-62
3036978-9	1987	These data suggest that PMN superoxide release induced by FMLP, A23187, and opsonized zymosan is likely modulated by amiloride-sensitive Na+-H+ exchange; and phorbol ester-induced superoxide anion release and degranulation by any stimulant do not appear to be modulated by inhibition of an amiloride-sensitive Na+-H+ exchange.	Amiloride	290-299	formyl peptide receptor 1	Homo sapiens	58-62
3037914-7	1987	At N-phenylmaleimide concentrations of less than 20 mumol/g hemoglobin, the Na-H exchanger is fixed in the activated state, so that even when the volume stimulus is removed by subsequent cell swelling, an amiloride-sensitive flux is seen.	Amiloride	205-214	solute carrier family 9 member A1	Canis lupus familiaris	76-90
2883187-3	1987	The recovery of pHi to its resting value was blocked by the removal of extracellular Na+, by the addition of extra-cellular H+, and by the addition of analogs of amiloride selective for inhibition of Na+/H+ exchange.	Amiloride	162-171	glucose-6-phosphate isomerase 1	Mus musculus	16-19
3036130-5	1987	Diferric transferrin induced proton release depends on external sodium and is inhibited by amiloride.	Amiloride	91-100	transferrin	Homo sapiens	9-20
3036130-7	1987	A tightly coupled association between the redox system and the antiport is shown by sodium dependence and amiloride inhibition of diferric transferrin reduction.	Amiloride	106-115	transferrin	Homo sapiens	139-150
3037340-2	1987	The p21-induced pH change was inhibited by amiloride treatment or growth of cells in medium low in sodium, suggesting a role for the Na+/H+ antiporter.	Amiloride	43-52	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	4-7
3034665-2	1987	Acid-loaded cells rapidly regained normal pHi by means of an amiloride-sensitive Na+/H+ exchange.	Amiloride	61-70	glucose-6-phosphate isomerase	Rattus norvegicus	42-45
3621057-10	1987	In HCO3(-)-free solutions amiloride reduced the rate of pHi recovery considerably.	Amiloride	26-35	glucose-6-phosphate isomerase	Homo sapiens	56-59
3621058-4	1987	The recovery of pHi was blocked by 1-2 mM amiloride.	Amiloride	42-51	glucose-6-phosphate isomerase	Homo sapiens	16-19
3621057-7	1987	In HCO3(-)-free solutions the diuretic amiloride (2 mM) reduced the rate of pHi recovery.	Amiloride	39-48	glucose-6-phosphate isomerase	Homo sapiens	76-79
3037340-3	1987	Amiloride was found to suppress p21-induced mitosis, also.	Amiloride	0-9	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	32-35
3599651-9	1987	When cell membrane potential was monitored in these experiments using the potential-sensitive fluorescent dye, bis-(1,3-dibutylbarbiturate) trimethine oxonol, the increase in pHi seen in the presence of Na+ was found to be electroneutral, whereas when that occurred in the presence of Na+, amiloride and HCO3-/CO2 was associated with membrane hyperpolarization.	Amiloride	290-299	glucose-6-phosphate isomerase	Homo sapiens	175-178
3031037-3	1987	The fact that the Na+/H+ exchange inhibitor, amiloride, blocks angiotensin II-stimulated Na+ influx and is itself a vasodilator suggests that Na+/H+ exchange may play a role in the angiotensin II-mediated effects on VSMC.	Amiloride	45-54	angiotensinogen	Rattus norvegicus	63-77
3031037-3	1987	The fact that the Na+/H+ exchange inhibitor, amiloride, blocks angiotensin II-stimulated Na+ influx and is itself a vasodilator suggests that Na+/H+ exchange may play a role in the angiotensin II-mediated effects on VSMC.	Amiloride	45-54	angiotensinogen	Rattus norvegicus	181-195
3031038-2	1987	Angiotensin II, a potent vasoconstrictor peptide, increases free cytoplasmic Ca2+ concentration ([Ca2+]i) in vascular smooth muscle cells (VSMC) by release of nonmitochondrial Ca2+ stores and stimulates an amiloride-sensitive Na+ influx, presumably via Na+/H+ exchange.	Amiloride	206-215	angiotensinogen	Homo sapiens	0-14
3030751-6	1987	The accumulation of c-fos mRNA and the transcriptional activation of c-fos induced by PDD or A23187 were inhibited by the protein kinase inhibitor H-7 and by quinidine and amiloride.	Amiloride	172-181	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	20-25
3106085-0	1987	Amiloride selectively inhibits the urokinase-type plasminogen activator.	Amiloride	0-9	plasminogen activator, urokinase	Homo sapiens	35-71
3106085-1	1987	The diuretic drug amiloride, an inhibitor of Na+ uptake, competitively inhibits the catalytic activity of the urokinase-type plasminogen activator (u-PA), with a Ki of 7 X 10(-6) M. Generation of plasmin, cleavage of peptide substrates, and interaction of u-PA with a specific macromolecular proteinase inhibitor are all prevented in the presence of the drug.	Amiloride	18-27	plasminogen activator, urokinase	Homo sapiens	110-146
3106085-1	1987	The diuretic drug amiloride, an inhibitor of Na+ uptake, competitively inhibits the catalytic activity of the urokinase-type plasminogen activator (u-PA), with a Ki of 7 X 10(-6) M. Generation of plasmin, cleavage of peptide substrates, and interaction of u-PA with a specific macromolecular proteinase inhibitor are all prevented in the presence of the drug.	Amiloride	18-27	plasminogen activator, urokinase	Homo sapiens	148-152
3106085-1	1987	The diuretic drug amiloride, an inhibitor of Na+ uptake, competitively inhibits the catalytic activity of the urokinase-type plasminogen activator (u-PA), with a Ki of 7 X 10(-6) M. Generation of plasmin, cleavage of peptide substrates, and interaction of u-PA with a specific macromolecular proteinase inhibitor are all prevented in the presence of the drug.	Amiloride	18-27	plasminogen	Homo sapiens	125-132
3106085-1	1987	The diuretic drug amiloride, an inhibitor of Na+ uptake, competitively inhibits the catalytic activity of the urokinase-type plasminogen activator (u-PA), with a Ki of 7 X 10(-6) M. Generation of plasmin, cleavage of peptide substrates, and interaction of u-PA with a specific macromolecular proteinase inhibitor are all prevented in the presence of the drug.	Amiloride	18-27	plasminogen activator, urokinase	Homo sapiens	256-260
3106085-1	1987	The diuretic drug amiloride, an inhibitor of Na+ uptake, competitively inhibits the catalytic activity of the urokinase-type plasminogen activator (u-PA), with a Ki of 7 X 10(-6) M. Generation of plasmin, cleavage of peptide substrates, and interaction of u-PA with a specific macromolecular proteinase inhibitor are all prevented in the presence of the drug.	Amiloride	18-27	endogenous retrovirus group K member 25	Homo sapiens	292-302
3106085-3	1987	The inhibition of u-PA by amiloride may be related to the previously reported inhibition of u-PA-type enzymes by Na+.	Amiloride	26-35	plasminogen activator, urokinase	Homo sapiens	18-22
3106085-3	1987	The inhibition of u-PA by amiloride may be related to the previously reported inhibition of u-PA-type enzymes by Na+.	Amiloride	26-35	plasminogen activator, urokinase	Homo sapiens	92-96
3106085-4	1987	Amiloride or related compounds could prove useful in selectively controlling u-PA-catalyzed extracellular proteolysis.	Amiloride	0-9	plasminogen activator, urokinase	Homo sapiens	77-81
3030751-6	1987	The accumulation of c-fos mRNA and the transcriptional activation of c-fos induced by PDD or A23187 were inhibited by the protein kinase inhibitor H-7 and by quinidine and amiloride.	Amiloride	172-181	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	69-74
3030871-5	1987	This regulatory range of pHi (= 0.7 pH units) was abolished by sodium-free Ringer"s or addition of 10(-3) M amiloride and also by 10(-4) M ouabain.	Amiloride	108-117	glucose-6-phosphate isomerase	Oryctolagus cuniculus	25-28
3815351-5	1987	Amiloride and 4,4"-diisothiocyanostilbene 2,2-disulfonic acid, inhibitors of the Na+/H+ and HCO3-/Cl- exchangers, respectively, decreased pHi in the presence of nigericin at low pHe.	Amiloride	0-9	glucose-6-phosphate isomerase	Homo sapiens	138-141
2436139-10	1987	Ouabain and amiloride both caused resting pHi to fall closer to equilibrium and largely abolished the gland"s responsiveness to ACh.	Amiloride	12-21	glucose-6-phosphate isomerase	Rattus norvegicus	42-45
3028491-9	1987	Under both experimental conditions, the pHi recovery after an intracellular acidification, introduced by exposure to 20% CO2 and by removal of NH4+, was found to be inhibited by 53% and 63%, respectively, in the absence of sodium and 60% and 72%, respectively, by 1 mM amiloride.	Amiloride	269-278	vasoactive intestinal peptide	Sus scrofa	40-43
3030848-8	1987	It has been possible to discriminate between the proliferative and dedifferentiating actions of EGF using amiloride, a non-specific inhibitor of the Na+/H+ antiporter.	Amiloride	106-115	epidermal growth factor	Homo sapiens	96-99
3030848-9	1987	An optimum concentration of amiloride (0.1 mM) was able to block EGF-stimulated incorporation of [3H]thymidine into DNA without preventing the blockade of iodide uptake, which implies that dedifferentiation is not a consequence of proliferation.	Amiloride	28-37	epidermal growth factor	Homo sapiens	65-68
3109389-4	1987	Preincubation with amiloride or replacing the extracellular Na+ with choline+ completely blocked the elevations stimulated by TRH or TPA, consistent with an activation of the Na+/H+ antiport mechanism.	Amiloride	19-28	thyrotropin releasing hormone	Rattus norvegicus	126-129
3029782-5	1987	The diuretic drug amiloride blocked pHi recovery.	Amiloride	18-27	glucose-6-phosphate isomerase	Homo sapiens	36-39
3022947-3	1986	When the cell-free cytosolic extracts were prepared from cells exposed to amiloride, at concentrations that inhibit the Na+/H+ exchange, a decrease of S6 kinase activity was observed only in exponential growing cells, suggesting the possibility of coupling of the Na+/H+ exchange with phosphorylation of intracellular proteins in these tumor cells.	Amiloride	74-83	ribosomal protein S6 kinase B1	Rattus norvegicus	151-160
3028147-8	1987	Possible explanations for the discrepancy in the literature concerning the interaction of Na+, H+, and amiloride with the Na+-H+ exchanger and the characteristics of the Na+-H+ exchange system in LLC-PK1 are discussed.	Amiloride	103-112	solute carrier family 9 member A2	Sus scrofa	122-138
3548704-10	1986	The synergistic inhibitory effects of amiloride and bumetanide on the two activities stimulated by serum growth factors, namely ODC induction (mid-G1) and thymidine incorporation into DNA (S-phase), suggested that the amiloride-sensitive Na+/H+ antiport system together with the bumetanide-sensitive Na+/K+ transporter play a role in the mitogenic signal.	Amiloride	38-47	ornithine decarboxylase, structural 1	Mus musculus	128-131
3548704-10	1986	The synergistic inhibitory effects of amiloride and bumetanide on the two activities stimulated by serum growth factors, namely ODC induction (mid-G1) and thymidine incorporation into DNA (S-phase), suggested that the amiloride-sensitive Na+/H+ antiport system together with the bumetanide-sensitive Na+/K+ transporter play a role in the mitogenic signal.	Amiloride	218-227	ornithine decarboxylase, structural 1	Mus musculus	128-131
3028151-4	1987	After intracellular acidification with ammonium chloride, pH regulation was inhibited with 1 mM amiloride or by omission of external sodium, consistent with a Na-H exchange mechanism.	Amiloride	96-105	glucose-6-phosphate isomerase	Rattus norvegicus	58-60
3101507-5	1987	The inhibitory effects of quinacrine on Na-Ca exchange activity are qualitatively similar to those reported previously for amiloride derivatives.	Amiloride	123-132	nascent polypeptide associated complex subunit alpha	Homo sapiens	40-45
2892632-8	1987	The osmotic permeability coefficient (LPD) increased significantly during the osmotic gradient reduction with 115 mM NaCl plus 0.25 mM amiloride or 230 mM sucrose in both groups.	Amiloride	135-144	acyl-CoA synthetase bubblegum family member 1	Homo sapiens	38-41
3772800-5	1986	Pressor responses to norepinephrine, tyramine, phenylephrine and clonidine were depressed significantly after amiloride, suggesting that amiloride interfered with alpha adrenoceptor-mediated vasoconstriction; vascular reactivity to arginine vasopressin, isoproterenol, histamine and acetylcholine was unaltered.	Amiloride	137-146	arginine vasopressin	Rattus norvegicus	241-252
3095787-6	1986	Furosemide addition (10(-5) mol X l-1) to CAL and MAL samples, or amiloride addition (10(-4) mol X l-1) to CCT and MCT samples reduced the rate of CO2 production to an extent almost similar to that obtained with ouabain, an observation suggesting that apical entry of Na+ was present in these non-perfused tubules.	Amiloride	66-75	FLVCR heme transporter 2	Rattus norvegicus	107-110
3018411-7	1986	Low concentrations of amiloride (less than 100 microM) potentiate the inhibitory effect of ANF in hormone-stimulated steroid secretion with a 3-fold decrease in ANF IC50 at 10 microM amiloride.	Amiloride	22-31	natriuretic peptide A	Bos taurus	91-94
3018411-7	1986	Low concentrations of amiloride (less than 100 microM) potentiate the inhibitory effect of ANF in hormone-stimulated steroid secretion with a 3-fold decrease in ANF IC50 at 10 microM amiloride.	Amiloride	22-31	natriuretic peptide A	Bos taurus	161-164
3018411-7	1986	Low concentrations of amiloride (less than 100 microM) potentiate the inhibitory effect of ANF in hormone-stimulated steroid secretion with a 3-fold decrease in ANF IC50 at 10 microM amiloride.	Amiloride	183-192	natriuretic peptide A	Bos taurus	91-94
3018411-9	1986	These results indicate that amiloride synergistically potentiates ANF inhibitory action by altering ANF receptor binding properties.	Amiloride	28-37	natriuretic peptide A	Bos taurus	66-69
3018411-9	1986	These results indicate that amiloride synergistically potentiates ANF inhibitory action by altering ANF receptor binding properties.	Amiloride	28-37	natriuretic peptide A	Bos taurus	100-103
3018411-0	1986	Amiloride potentiates atrial natriuretic factor inhibitory action by increasing receptor binding in bovine adrenal zona glomerulosa.	Amiloride	0-9	natriuretic peptide A	Bos taurus	22-47
3018411-1	1986	The interaction of atrial natriuretic factor (ANF) with the diuretic amiloride was studied in bovine adrenal zona glomerulosa.	Amiloride	69-78	natriuretic peptide A	Bos taurus	19-44
3018411-1	1986	The interaction of atrial natriuretic factor (ANF) with the diuretic amiloride was studied in bovine adrenal zona glomerulosa.	Amiloride	69-78	natriuretic peptide A	Bos taurus	46-49
3018411-2	1986	Amiloride enhances 2 to 3-fold high affinity binding of [125I] ANF to zona glomerulosa membrane receptor with an ED50 of 10 microM.	Amiloride	0-9	natriuretic peptide A	Bos taurus	63-66
3018411-6	1986	Amiloride and ATP opposite effects on [125I] ANF binding are mutually competitive.	Amiloride	0-9	natriuretic peptide A	Bos taurus	45-48
3017962-4	1986	After an acid load, the cells regulate pHi in the absence of HCO3- by a Na+ (or Li+)-dependent, amiloride-inhibitable mechanism (indicative of Na+/H+ antiport).	Amiloride	96-105	glucose-6-phosphate isomerase	Homo sapiens	39-42
2423136-3	1986	In the 0.1-1 mM range, amiloride transiently reduced pHi of glucose-deprived islets and allowed glucose to induce a sustained decrease in pHi of the islet cells.	Amiloride	23-32	glucose-6-phosphate isomerase	Rattus norvegicus	53-56
3016497-5	1986	The structure-activity relationships in the amiloride series were characterized by testing the effect of these compounds on the DMO-derived pHi changes and on the FMLP-stimulated rate of 22Na+ efflux from the cells.	Amiloride	44-53	glucose-6-phosphate isomerase	Homo sapiens	140-143
3016497-12	1986	The development of potent derivatives of amiloride should provide powerful tools for assessing the role of FMLP-activated Na+/H+ exchange and the resultant pHi transients on stimulated neutrophil functions.	Amiloride	41-50	glucose-6-phosphate isomerase	Homo sapiens	156-159
3084468-2	1986	An early intracellular event caused by exposure to IL-1 is an amiloride-sensitive progressive rise in the total concentration of intracellular sodium ([Na]i), caused by influx of Na+ from outside, and a transient fall in total intracellular calcium.	Amiloride	62-71	interleukin 1 complex	Mus musculus	51-55
3084468-4	1986	IL-1-induced differentiation is also blocked by amiloride suggesting that stimulation of Na+/H+ exchange may play a role in IL-1-induced differentiation.	Amiloride	48-57	interleukin 1 complex	Mus musculus	0-4
3084468-4	1986	IL-1-induced differentiation is also blocked by amiloride suggesting that stimulation of Na+/H+ exchange may play a role in IL-1-induced differentiation.	Amiloride	48-57	interleukin 1 complex	Mus musculus	124-128
3734584-8	1986	Amiloride caused intracellular acidification, and the reduction of pHi by amiloride was enhanced in the presence of NaTC, although this enhancement is difficult to interpret because of the large effects of amiloride on pHi relative to those of NaTC.	Amiloride	74-83	glucose-6-phosphate isomerase	Rattus norvegicus	67-70
3734584-8	1986	Amiloride caused intracellular acidification, and the reduction of pHi by amiloride was enhanced in the presence of NaTC, although this enhancement is difficult to interpret because of the large effects of amiloride on pHi relative to those of NaTC.	Amiloride	206-215	glucose-6-phosphate isomerase	Rattus norvegicus	67-70
2425367-2	1986	Addition of kallikrein (an enzyme of unknown function normally found in urine) to the mucosal solution of the mammalian urinary bladder epithelium resulted in the loss (over a 2-hr period) of amiloride-sensitive Na+ current and an increase in the leak current that is amiloride insensitive.	Amiloride	192-201	kallikrein related peptidase 4	Homo sapiens	12-22
2425367-2	1986	Addition of kallikrein (an enzyme of unknown function normally found in urine) to the mucosal solution of the mammalian urinary bladder epithelium resulted in the loss (over a 2-hr period) of amiloride-sensitive Na+ current and an increase in the leak current that is amiloride insensitive.	Amiloride	268-277	kallikrein related peptidase 4	Homo sapiens	12-22
2423136-3	1986	In the 0.1-1 mM range, amiloride transiently reduced pHi of glucose-deprived islets and allowed glucose to induce a sustained decrease in pHi of the islet cells.	Amiloride	23-32	glucose-6-phosphate isomerase	Rattus norvegicus	138-141
3004467-0	1986	Atrial natriuretic factor and cGMP inhibit amiloride-sensitive Na+ transport in the cultured renal epithelial cell line, LLC-PK1.	Amiloride	43-52	prokineticin 1	Homo sapiens	125-128
3953781-7	1986	The rate of amiloride-sensitive H+ efflux could be calculated from the rate of change of pHi, using a buffering power of 28 mmol X l-1 X pH unit-1, determined by titration with NH+4 or propionate-.	Amiloride	12-21	glucose-6-phosphate isomerase	Homo sapiens	89-92
3511352-6	1986	The addition of 0.1 mmol/L amiloride had no influence on pHi without glucose and decreased pHi in the presence of 2.8 mmol/L glucose by .14 unit.	Amiloride	27-36	glucose-6-phosphate isomerase	Rattus norvegicus	91-94
3511352-9	1986	These results suggest that the amiloride-sensitive Na:H exchanger plays a major role in regulation of pHi, but another modality for pHi regulation exists to compensate for inhibition of Na:H exchange under conditions of an acid load.	Amiloride	31-40	glucose-6-phosphate isomerase	Rattus norvegicus	102-105
3511352-9	1986	These results suggest that the amiloride-sensitive Na:H exchanger plays a major role in regulation of pHi, but another modality for pHi regulation exists to compensate for inhibition of Na:H exchange under conditions of an acid load.	Amiloride	31-40	glucose-6-phosphate isomerase	Rattus norvegicus	132-135
3091839-4	1986	Comparison of the spontaneous decline of the SCC with the decline induced by a small dose of amiloride, where an increase in R was observed, indicates that the spontaneous decline cannot be explained simply as a reduction of the Na permeability of the apical membrane by self-inhibition of feedback inhibition of the apical membrane Na channels.	Amiloride	93-102	serpin family B member 3	Homo sapiens	45-48
3006669-9	1986	However, the marked increase in the phosphorylation state of the EGF receptor at other sites caused by PMA is abolished in the presence of amiloride.	Amiloride	139-148	epidermal growth factor receptor	Homo sapiens	65-77
3519243-0	1986	Effects of combined therapy with amiloride and hydrochlorothiazide on plasma and total body potassium, blood pressure, and the renin-angiotensin-aldosterone system in hypertensive patients.	Amiloride	33-42	renin	Homo sapiens	127-132
3009823-6	1986	When pHo was kept at 8.0, the amiloride-sensitive Na+ entry was abolished as pHi was increased from 6.4 to 7.8.	Amiloride	30-39	glucose-6-phosphate isomerase	Homo sapiens	77-80
3009823-8	1986	Furthermore, in the absence of a chemical gradient for Na+ (Nai+ = Nao+ = 15 mM, Em = +6.7 mV), an outward H+ gradient (pHi = 6.4, pHo = 8.0) promoted a net amiloride-sensitive Na+ uptake which was abolished at an external pH of 6.0.	Amiloride	157-166	glucose-6-phosphate isomerase	Homo sapiens	120-123
3027598-10	1986	To assess the requirement for Na+ transport, we evaluated the effect of 1 mM ouabain, 10 microM tetrodotoxin (TTX), or 100 microM amiloride on CuHis stimulation of LHRH release.	Amiloride	130-139	gonadotropin releasing hormone 1	Rattus norvegicus	164-168
2997159-7	1985	The FMLP-induced 22Na+ influx was saturable with respect to external Na+ (Km 26-35 mM, Vmax approximately 28 meq/liter X min), was electroneutral, and could be competitively inhibited by amiloride (Ki 10.6 microM).	Amiloride	187-196	formyl peptide receptor 1	Homo sapiens	4-8
3001217-12	1985	The basolateral Na-dependent pHi recovery was reversibly inhibited by amiloride.	Amiloride	70-79	glucose-6-phosphate isomerase	Oryctolagus cuniculus	29-32
2935488-6	1985	Cellular ATPases, inhibited by quercetin, but not the ouabain-sensitive Na+, K+-ATPase, appeared to participate, whereas the amiloride-sensitive plasma membrane Na+/H+ exchanger and the intracellular levels of cGMP did not seem to influence the system.	Amiloride	125-134	dynein axonemal heavy chain 8	Homo sapiens	9-15
3877468-5	1985	Ouabain caused Aab to increase markedly to 303 neq/cm2 in 30 min, whereas amiloride inhibition of apical membrane Na+ entry reduced markedly the rate of increase of Aab caused by ouabain (7.3 neq X cm-2 X min-1 in control and 1.7 neq X cm-2 X min-1 in the presence of amiloride).	Amiloride	74-83	CD59 molecule (CD59 blood group)	Homo sapiens	205-210
3877468-5	1985	Ouabain caused Aab to increase markedly to 303 neq/cm2 in 30 min, whereas amiloride inhibition of apical membrane Na+ entry reduced markedly the rate of increase of Aab caused by ouabain (7.3 neq X cm-2 X min-1 in control and 1.7 neq X cm-2 X min-1 in the presence of amiloride).	Amiloride	74-83	CD59 molecule (CD59 blood group)	Homo sapiens	243-248
2997159-12	1985	The data indicate that FMLP activates an otherwise quiescent, amiloride-sensitive Na+/H+ exchange.	Amiloride	62-71	formyl peptide receptor 1	Homo sapiens	23-27
4032303-6	1985	In HCO3--free solutions, pHi recovery from acidification was blocked by removing external Na or by amiloride (2 mM).	Amiloride	99-108	glucose-6-phosphate isomerase	Homo sapiens	25-28
2995378-10	1985	IL 2-driven proliferation occurred in nominally bicarbonate-free medium in the presence of concentrations of amiloride analogs sufficient to inhibit the Na+/H+ antiport and prevent intracellular alkalinization.	Amiloride	109-118	interleukin 2	Homo sapiens	0-4
3874870-1	1985	We have recently shown that both lipopolysaccharide (LPS) and the phorbol ester, 12-O-tetradecanoyl phorbol 13-acetate (TPA) induce differentiation in the transformed murine pre-B lymphocyte cell line 70Z/3 by enhancing Na+-H+ exchange across the plasma membrane through an amiloride-sensitive transport system (Rosoff, P.M., Stein, L.F., and Cantley, L.C.	Amiloride	274-283	toll-like receptor 4	Mus musculus	53-56
4037093-6	1985	A reduction of luminal Na+ from 20 mM to 0 also reduced pHi from 7.15 +/- 0.06 to 7.04 +/- 0.08, and this pHi reduction was blocked by luminal addition of 1 mM amiloride.	Amiloride	160-169	glucose-6-phosphate isomerase	Homo sapiens	56-59
4037093-6	1985	A reduction of luminal Na+ from 20 mM to 0 also reduced pHi from 7.15 +/- 0.06 to 7.04 +/- 0.08, and this pHi reduction was blocked by luminal addition of 1 mM amiloride.	Amiloride	160-169	glucose-6-phosphate isomerase	Homo sapiens	106-109
2995444-3	1985	This pHi change was sensitive to amiloride (apparent Ki 78 microM), an inhibitor of Na/H countertransport.	Amiloride	33-42	glucose-6-phosphate isomerase	Homo sapiens	5-8
2995444-5	1985	In the presence of 1 mM amiloride, which nearly blocked the pHi transient elicited by FMLP, or in the absence of external Na, where intracellular acidification was observed in FMLP-stimulated cells, O2- release was still roughly 25-45% of normal.	Amiloride	24-33	glucose-6-phosphate isomerase	Homo sapiens	60-63
2995444-5	1985	In the presence of 1 mM amiloride, which nearly blocked the pHi transient elicited by FMLP, or in the absence of external Na, where intracellular acidification was observed in FMLP-stimulated cells, O2- release was still roughly 25-45% of normal.	Amiloride	24-33	formyl peptide receptor 1	Homo sapiens	86-90
2995444-5	1985	In the presence of 1 mM amiloride, which nearly blocked the pHi transient elicited by FMLP, or in the absence of external Na, where intracellular acidification was observed in FMLP-stimulated cells, O2- release was still roughly 25-45% of normal.	Amiloride	24-33	formyl peptide receptor 1	Homo sapiens	176-180
2988347-3	1985	At a perfusion rate of 14 nl/min, addition of 10(-3) M amiloride to artificial early proximal tubular fluid reduced bicarbonate absorption from 103 +/- 7 to 81 +/- 5 pmol mm-1 X min-1 and volume absorption from 2.03 +/- 0.15 to 1.57 +/- 0.06 nl X mm-1 X min-1.	Amiloride	55-64	CD59 molecule (CD59 blood group)	Homo sapiens	254-259
2988347-6	1985	At a perfusion rate of 41 nl/min, 10(-3) M amiloride reduced bicarbonate absorption from 179 +/- 8 to 114 +/- 9 pmol X mm-1 X min-1, a significantly greater inhibition than that seen in tubules perfused at 14 nl/min.	Amiloride	43-52	CD59 molecule (CD59 blood group)	Homo sapiens	126-131
2988347-3	1985	At a perfusion rate of 14 nl/min, addition of 10(-3) M amiloride to artificial early proximal tubular fluid reduced bicarbonate absorption from 103 +/- 7 to 81 +/- 5 pmol mm-1 X min-1 and volume absorption from 2.03 +/- 0.15 to 1.57 +/- 0.06 nl X mm-1 X min-1.	Amiloride	55-64	CD59 molecule (CD59 blood group)	Homo sapiens	178-183
3969096-6	1985	Amiloride administration was also associated with a significant increase in urine osmolality (from 575 +/- 54 to 699 +/- 48 mOsm per kilogram of H2O; P less than 0.005) measured after fluid deprivation and the injection of exogenous vasopressin.	Amiloride	0-9	arginine vasopressin	Homo sapiens	233-244
2989338-13	1985	In rats infused with ANF, the rate of amiloride-sensitive Na+-H+ exchange across the brush border membrane (BBM) was significantly (P less than 0.05) decreased (-40%), whereas the diffusional 22Na+ uptake (0.5 min) and the equilibrium (120 min) uptake of 22Na+ were not changed.	Amiloride	38-47	natriuretic peptide A	Rattus norvegicus	21-24
2579572-5	1985	This insulin-induced recovery was abolished by 1 mM amiloride, a Na-H exchange inhibitor.	Amiloride	52-61	insulin	Homo sapiens	5-12
2982824-1	1985	Addition of amiloride to A431 human epidermoid carcinoma cell membranes inhibited autophosphorylation of the epidermal growth factor (EGF) receptor.	Amiloride	12-21	epidermal growth factor receptor	Homo sapiens	109-147
2982824-2	1985	The tyrosine phosphorylation of histone H2B catalyzed by an affinity-purified preparation of EGF receptor was also inhibited by amiloride.	Amiloride	128-137	epidermal growth factor receptor	Homo sapiens	93-105
2982824-4	1985	The tyrosine phosphorylation of histone H2B catalyzed by the purified EGF receptor was inhibited by amiloride at concentrations identical to those previously reported to block EGF action on cell proliferation (Ki = 350 microM).	Amiloride	100-109	epidermal growth factor receptor	Homo sapiens	70-82
2982824-5	1985	Amiloride similarly inhibited the tyrosine phosphorylation of the human placental insulin receptor and the platelet-derived growth factor receptor of Swiss 3T3 cells.	Amiloride	0-9	insulin receptor	Homo sapiens	82-98
2982824-6	1985	Immunoprecipitation of the EGF receptor from A431 cells labeled for 24 h with [32P]phosphate demonstrated that amiloride decreased the phosphorylation of the EGF receptor on serine and threonine residues and blocked the effect of EGF to cause phosphorylation of the receptor on tyrosine residues.	Amiloride	111-120	epidermal growth factor receptor	Homo sapiens	27-39
2982824-6	1985	Immunoprecipitation of the EGF receptor from A431 cells labeled for 24 h with [32P]phosphate demonstrated that amiloride decreased the phosphorylation of the EGF receptor on serine and threonine residues and blocked the effect of EGF to cause phosphorylation of the receptor on tyrosine residues.	Amiloride	111-120	epidermal growth factor receptor	Homo sapiens	158-170
3882483-5	1985	In sodium-containing medium, amiloride inhibited GVBD and prevented insulin or progesterone-induced increases in pHi but the hormone-induced increase in S6 phosphorylation was unaffected.	Amiloride	29-38	insulin S homeolog	Xenopus laevis	68-75
3920759-4	1985	That tissue kallikreins can be inhibited by monovalent cations and some drugs (e.g., amiloride) and that kallikrein inhibitors affect cation transport across epithelial surfaces containing such enzymes must be reconciled with the new observations of kinin-induced chloride secretion.	Amiloride	85-94	kallikrein related peptidase 4	Homo sapiens	12-22
3978424-3	1985	In nominally HCO-3-free solutions, pHi recovery from acid loading was blocked by 10(-3)M amiloride.	Amiloride	89-98	glucose-6-phosphate isomerase	Homo sapiens	35-38
3911164-3	1985	Oxytocin produced a large and sustained increase in the amiloride-inhibitable short circuit current (Im) which was accompanied by a large increase of both apical and basolateral membrane conductance (ga and gb, respectively).	Amiloride	56-65	oxytocin/neurophysin I prepropeptide	Homo sapiens	0-8
6095295-6	1984	These changes of pHc were blocked when ouabain-treated glands had been preequilibrated for 10 min with 1 mM amiloride, and this block was overcome by adding 10 microM monensin (an ionophore that artificially exchanges Na+ for H+).	Amiloride	108-117	solute carrier family 25 member 3	Homo sapiens	17-20
6095295-8	1984	Under these conditions, pHc decreased from 7.02 to approximately equal to 6.5; subsequent alkalinization of cells back to control pHc was stimulated by Na+ (t1/2 approximately equal to 60 sec), but not K+, and was inhibited by 1 mM amiloride.	Amiloride	232-241	solute carrier family 25 member 3	Homo sapiens	130-133
6208556-0	1984	Inhibition of epidermal growth factor-induced mitogenesis by amiloride and an analog: evidence against a requirement for Na+/H+ exchange.	Amiloride	61-70	epidermal growth factor	Mus musculus	14-37
6334130-5	1984	At pHi greater than or equal to 7.0, amiloride-sensitive net H+ fluxes are not detectable.	Amiloride	37-46	glucose-6-phosphate isomerase	Rattus norvegicus	3-6
6334130-9	1984	Measurements of pHi in Na+-loaded cells suspended in Na+-free medium revealed an amiloride-sensitive cytoplasmic acidification, which is indicative of exchange of internal Na+ for external H+.	Amiloride	81-90	glucose-6-phosphate isomerase	Rattus norvegicus	16-19
6208556-4	1984	Cells incubated with 200 microM amiloride for 24 hr showed nearly complete inhibition of stimulation by EGF.	Amiloride	32-41	epidermal growth factor	Mus musculus	104-107
6086680-2	1984	We recently demonstrated that amiloride inhibits thrombin-initiated DNA synthesis not by inhibiting an early event occurring during the first 8 hr, but rather by inhibiting some later event 8 to 12 hr after thrombin addition.	Amiloride	30-39	coagulation factor II, thrombin	Homo sapiens	49-57
6386025-6	1984	Stimulation of renin, angiotensin II, aldosterone and 18-OH B occurred with both drugs but was greater with amiloride in each case.	Amiloride	108-117	renin	Homo sapiens	15-20
6086680-2	1984	We recently demonstrated that amiloride inhibits thrombin-initiated DNA synthesis not by inhibiting an early event occurring during the first 8 hr, but rather by inhibiting some later event 8 to 12 hr after thrombin addition.	Amiloride	30-39	coagulation factor II, thrombin	Homo sapiens	207-215
6330063-7	1984	Recovery of pHi and concomitant Na+/H+ fluxes are reversibly inhibited by amiloride (half-maximal effect at approximately 0.1 mM).	Amiloride	74-83	glucose-6-phosphate isomerase	Homo sapiens	12-15
6330063-12	1984	The response of pHi to alkaline pHo shifts is abolished by amiloride and by Na+ removal.	Amiloride	59-68	glucose-6-phosphate isomerase	Homo sapiens	16-19
6330063-13	1984	It is concluded that pHi in HF cells is closely regulated by an amiloride-sensitive, reversible Na+/H+ exchanger, which is driven by the transmembrane concentration gradients for Na+ and H+.	Amiloride	64-73	glucose-6-phosphate isomerase	Homo sapiens	21-24
6327397-3	1984	Regulation of pHi appears to occur by Na:H and HCO3:Cl exchange in the plasma membrane, because inhibition by 0.1 mM amiloride and 0.5 mM 4,4"-diisothiocyano-2,2"-stilbene disulfonic acid (DIDS), respectively, induces constant spike activity in the presence of 11.1 mM glucose.	Amiloride	117-126	glucose-6-phosphate isomerase	Rattus norvegicus	14-17
6420507-11	1983	On the basis of observations that A23187 did not activate K loss from cells during RVI (when the Na/H exchange was functioning) and that amiloride inhibited K/H exchange by swollen cells only when cells had previously been shrunk in the presence of amiloride, I concluded that Na/H and K/H exchange are mediated by the same membrane transport moiety.	Amiloride	137-146	TANK binding kinase 1	Homo sapiens	277-287
6587348-0	1984	Inhibition of Na+/Ca2+ exchange in membrane vesicle and papillary muscle preparations from guinea pig heart by analogs of amiloride.	Amiloride	122-131	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	18-21
6693420-3	1984	Both the membrane potential change and the rapid sodium influx can be inhibited by a fast acting analog of amiloride, a sodium channel blocker, while valinomycin, a potassium ionophore, has no effect on the potential change nor on the sodium uptake, suggesting that the transmembrane potassium gradient is not important in the thrombin-induced depolarization.	Amiloride	107-116	coagulation factor II, thrombin	Homo sapiens	327-335
6369882-5	1984	Hydrochlorothiazide and amiloride, often used in combination, both have a t 1/2 of about 10 h. Canrenone, an active metabolite of spironolactone, has a t 1/2 of 15-20 h. Chlorthalidone is eliminated very slowly with a t 1/2 of about two days.	Amiloride	24-33	interleukin 1 receptor like 1	Homo sapiens	74-77
6369882-5	1984	Hydrochlorothiazide and amiloride, often used in combination, both have a t 1/2 of about 10 h. Canrenone, an active metabolite of spironolactone, has a t 1/2 of 15-20 h. Chlorthalidone is eliminated very slowly with a t 1/2 of about two days.	Amiloride	24-33	interleukin 1 receptor like 1	Homo sapiens	152-166
6369882-5	1984	Hydrochlorothiazide and amiloride, often used in combination, both have a t 1/2 of about 10 h. Canrenone, an active metabolite of spironolactone, has a t 1/2 of 15-20 h. Chlorthalidone is eliminated very slowly with a t 1/2 of about two days.	Amiloride	24-33	interleukin 1 receptor like 1	Homo sapiens	87-90
6699780-4	1984	Vasopressin (0.05 u./ml), which on average increased sodium transport 2.9 times and concurrently increased the rate of carbon dioxide production in these transporting tissues, also altered the carbon dioxide production of non-transporting, amiloride-treated control hemibladders.	Amiloride	240-249	arginine vasopressin	Homo sapiens	0-11
6628670-1	1983	The Na+-induced release of accumulated Ca2+ from heart mitochondria is inhibited by amiloride, benzamil and several other amiloride analogues.	Amiloride	84-93	carbonic anhydrase 2	Homo sapiens	39-42
6630302-0	1983	Demonstration of a late amiloride-sensitive event as a necessary step in initiation of DNA synthesis by thrombin.	Amiloride	24-33	coagulation factor II	Mus musculus	104-112
6630302-1	1983	Amiloride, a Na+ influx inhibitor, has been shown to inhibit initiation of DNA synthesis by thrombin in mouse embryo fibroblast-like cells.	Amiloride	0-9	coagulation factor II	Mus musculus	92-100
6630302-2	1983	Long exposures (24 hr) to high concentrations of amiloride inhibited incorporation of thymidine into the DNA of both thrombin-stimulated and nonstimulated cells, suggesting that this inhibition might not be specific for thrombin-initiated DNA synthesis.	Amiloride	49-58	coagulation factor II	Mus musculus	117-125
6630302-2	1983	Long exposures (24 hr) to high concentrations of amiloride inhibited incorporation of thymidine into the DNA of both thrombin-stimulated and nonstimulated cells, suggesting that this inhibition might not be specific for thrombin-initiated DNA synthesis.	Amiloride	49-58	coagulation factor II	Mus musculus	220-228
6630302-5	1983	The presence of amiloride (100 microM) during a 12-hr exposure to thrombin did not block thrombin-initiated DNA synthesis or cell division but did delay the onset of DNA synthesis and the peak of thymidine incorporation into DNA by approximately 3 hr, suggesting that early initiation events might proceed in the presence of amiloride.	Amiloride	16-25	coagulation factor II	Mus musculus	66-74
6630302-7	1983	This stimulation was amiloride-sensitive under the same conditions used for growth experiments, suggesting that amiloride was inhibiting thrombin-stimulated Na+ transport in this system.	Amiloride	21-30	coagulation factor II	Mus musculus	137-145
6630302-7	1983	This stimulation was amiloride-sensitive under the same conditions used for growth experiments, suggesting that amiloride was inhibiting thrombin-stimulated Na+ transport in this system.	Amiloride	112-121	coagulation factor II	Mus musculus	137-145
6630302-8	1983	Additional experiments showed that exposing cells to amiloride only during the first 8 hr after thrombin addition did not inhibit initiation.	Amiloride	53-62	coagulation factor II	Mus musculus	96-104
6630302-9	1983	The presence of amiloride from 8-12 hr after thrombin addition maximally inhibited thrombin-stimulated DNA synthesis.	Amiloride	16-25	coagulation factor II	Mus musculus	45-53
6630302-9	1983	The presence of amiloride from 8-12 hr after thrombin addition maximally inhibited thrombin-stimulated DNA synthesis.	Amiloride	16-25	coagulation factor II	Mus musculus	83-91
6630302-10	1983	Together these results demonstrate that amiloride inhibits thrombin-initiated DNA synthesis not by inhibiting an early event occurring during the first 8 hr, but rather by inhibiting some later event 8-12 hr after thrombin addition.	Amiloride	40-49	coagulation factor II	Mus musculus	59-67
6630302-10	1983	Together these results demonstrate that amiloride inhibits thrombin-initiated DNA synthesis not by inhibiting an early event occurring during the first 8 hr, but rather by inhibiting some later event 8-12 hr after thrombin addition.	Amiloride	40-49	coagulation factor II	Mus musculus	214-222
6628670-0	1983	Inhibition of Na+-dependent Ca2+ efflux from heart mitochondria by amiloride analogues.	Amiloride	67-76	carbonic anhydrase 2	Homo sapiens	28-31
6420546-13	1983	In fibres depolarized in 50 mM-K and constant Cl, either 0.1 mM-SITS or 0.5 mM-amiloride slowed pHi recovery from CO2 exposure by about 50%.	Amiloride	79-88	glucose-6-phosphate isomerase	Homo sapiens	96-99
6195155-1	1983	Epidermal growth factor (EGF) increases Na+ uptake in several cell types through an electroneutral, amiloride-sensitive pathway putatively identified as Na+/H+ countertransport.	Amiloride	100-109	epidermal growth factor	Homo sapiens	0-23
6195155-1	1983	Epidermal growth factor (EGF) increases Na+ uptake in several cell types through an electroneutral, amiloride-sensitive pathway putatively identified as Na+/H+ countertransport.	Amiloride	100-109	epidermal growth factor	Homo sapiens	25-28
6195155-4	1983	257, 4883-4889) that EGF rapidly activates amiloride-sensitive net Na+ influx in the A431 human epidermoid carcinoma cell line.	Amiloride	43-52	epidermal growth factor	Homo sapiens	21-24
6195155-10	1983	The pHi increase is half-maximal at 5-10 ng/ml of EGF, is dependent on external Na+, independent of external Ca2+, and inhibited by millimolar amiloride.	Amiloride	143-152	glucose-6-phosphate isomerase	Homo sapiens	4-7
6195155-10	1983	The pHi increase is half-maximal at 5-10 ng/ml of EGF, is dependent on external Na+, independent of external Ca2+, and inhibited by millimolar amiloride.	Amiloride	143-152	epidermal growth factor	Homo sapiens	50-53
6628670-1	1983	The Na+-induced release of accumulated Ca2+ from heart mitochondria is inhibited by amiloride, benzamil and several other amiloride analogues.	Amiloride	122-131	carbonic anhydrase 2	Homo sapiens	39-42
6306015-8	1983	These observations suggest that both NGF and EGF activate an amiloride-sensitive, electroneutral Na+,H+ exchange mechanism in PC12 cells.	Amiloride	61-70	nerve growth factor	Rattus norvegicus	37-40
6851418-9	1983	Distal tubular blockade with a combination of frusemide and amiloride was employed to differentiate between proximal and distal tubular sites of action of ANF.	Amiloride	60-69	natriuretic peptide A	Rattus norvegicus	155-158
6352481-0	1983	Inhibition of furosemide-induced increases in plasma renin activity by amiloride.	Amiloride	71-80	LOW QUALITY PROTEIN: renin	Oryctolagus cuniculus	53-58
6306015-11	1983	In the presence of amiloride, this stimulated growth by NGF and EGF was abolished.	Amiloride	19-28	nerve growth factor	Rattus norvegicus	56-59
6306015-13	1983	From these observations it is concluded that in PC12 cells: (a) NGF has an initial growth stimulating effect; (b) neurite outgrowth is independent of increased amiloride-sensitive Na+ influx; and (c) growth stimulation by NGF and EGF is associated with increased amiloride-sensitive Na+ influx.	Amiloride	263-272	nerve growth factor	Rattus norvegicus	64-67
6306015-13	1983	From these observations it is concluded that in PC12 cells: (a) NGF has an initial growth stimulating effect; (b) neurite outgrowth is independent of increased amiloride-sensitive Na+ influx; and (c) growth stimulation by NGF and EGF is associated with increased amiloride-sensitive Na+ influx.	Amiloride	263-272	nerve growth factor	Rattus norvegicus	222-225
6300103-0	1983	Epidermal growth factor stimulates amiloride-sensitive 22Na+ uptake in A431 cells.	Amiloride	35-44	epidermal growth factor	Homo sapiens	0-23
6300103-2	1983	Epidermal growth factor (EGF) increases Na+ uptake in several cell types through an electroneutral, amiloride-sensitive pathway putatively identified as Na+/H+ countertransport.	Amiloride	100-109	epidermal growth factor	Homo sapiens	0-23
6300103-2	1983	Epidermal growth factor (EGF) increases Na+ uptake in several cell types through an electroneutral, amiloride-sensitive pathway putatively identified as Na+/H+ countertransport.	Amiloride	100-109	epidermal growth factor	Homo sapiens	25-28
6300103-6	1983	Amiloride inhibits the EGF-dependent Na+ uptake (65% inhibition at 3 mM, ID50 approximately 0.3 mM) and inhibits much less the EGF-independent uptake.	Amiloride	0-9	epidermal growth factor	Homo sapiens	23-26
6300103-6	1983	Amiloride inhibits the EGF-dependent Na+ uptake (65% inhibition at 3 mM, ID50 approximately 0.3 mM) and inhibits much less the EGF-independent uptake.	Amiloride	0-9	epidermal growth factor	Homo sapiens	127-130
6300103-9	1983	1) EGF effectively stimulates an amiloride-sensitive 22Na+ uptake in the absence of external Ca2+.	Amiloride	33-42	epidermal growth factor	Homo sapiens	3-6
6601226-2	1983	The increase in Na transport is due to an increase in the unidirectional influx of sodium, is amiloride sensitive and is prevented with pretreatment with indomethacin, mefanamic acid and phospholipase inhibitor, mepacrine.	Amiloride	94-103	LY6/PLAUR domain containing 8	Homo sapiens	187-210
6299802-1	1983	The diuretic drug amiloride antagonises the insulin-dependent increase in phosphorylation of ATP-citrate lyase in hepatocytes isolated from rats that had been starved and refed a fat-free diet.	Amiloride	18-27	ATP citrate lyase	Rattus norvegicus	93-110
6299802-2	1983	Studies with a range of protein kinases and protein phosphatases that have been shown to phosphorylate or dephosphorylate purified ATP-citrate lyase in vitro revealed that amiloride was a non-specific inhibitor of all protein kinases tested, but did not significantly affect any of the protein phosphatases.	Amiloride	172-181	ATP citrate lyase	Rattus norvegicus	131-148
6338733-4	1983	Amiloride, a specific blocker of the transmembrane sodium proton exchange, has been used to demonstrate that this mechanism is also operative in the beta-cell membrane in the control of pHi.	Amiloride	0-9	glucose-6-phosphate isomerase 1	Mus musculus	186-189
6339076-5	1983	In addition, it was observed that the Na+ influx stimulated by Lys-bradykinin or by the combination of four growth factors was completely inhibited by the amiloride analog benzamil.	Amiloride	155-164	kininogen 1	Homo sapiens	67-77
6308014-3	1983	Furthermore, in exponentially growing cells, EGF induces a rapid increase in amiloride-sensitive Na+ influx, followed by stimulation of the (Na+-K+)ATPase, indicating that activation of the Na+/H+ exchange mechanism in N1E-115 cells [1] may be induced by EGF.	Amiloride	77-86	epidermal growth factor	Mus musculus	45-48
6984193-2	1982	Initial results show that (i) there is no significant difference in membrane potential between growing and quiescent cells, (ii) addition of epidermal growth factor or serum to quiescent BSC-1 cells induces a brief and transient depolarization, (iii) the mitogenic response of BSC-1 cells to epidermal growth factor and the transient depolarization show similar concentration dependences, and (iv) serum addition to quiescent BSC-1 cells induces a sustained increase in Na+ influx that is electroneutral and amiloride sensitive.	Amiloride	508-517	epidermal growth factor	Homo sapiens	141-164
6761369-0	1982	The effect of amiloride on the renin-aldosterone system in primary hyperaldosteronism and Bartter"s syndrome.	Amiloride	14-23	renin	Homo sapiens	31-36
6761369-5	1982	In summary, amiloride therapy (1) increased plasma potassium in both diseases; (2) increased plasma renin activity (PRA) in primary hyperaldosteronism but decreased PRA in Bartter"s syndrome; and (3) increased plasma aldosterone in both diseases.	Amiloride	12-21	renin	Homo sapiens	100-105
6261811-6	1981	In primary cultured rat hepatocytes, amiloride markedly depressed the stimulation of alpha-aminoisobutyric acid transport by glucagon, or a mixture of glucagon, insulin and epidermal growth factor.	Amiloride	37-46	epidermal growth factor like 1	Rattus norvegicus	173-196
7272596-1	1981	1 The effect of amiloride was studied on contractions and tritium release from rat vas deferens preloaded with [3H]-noradrenaline.	Amiloride	16-25	arginine vasopressin	Rattus norvegicus	83-86
7272596-7	1981	7 It is concluded that amiloride may inhibit the contractions of rat vas deferens by inhibiting the release of noradrenaline.	Amiloride	23-32	arginine vasopressin	Rattus norvegicus	69-72
7021411-4	1981	Kallikrein-stimulated renin release was completely abolished by trasylol and by amiloride, but was not affected by soybean trypsin inhibitor.	Amiloride	80-89	kallikrein related peptidase 4	Homo sapiens	0-10
7021411-4	1981	Kallikrein-stimulated renin release was completely abolished by trasylol and by amiloride, but was not affected by soybean trypsin inhibitor.	Amiloride	80-89	renin	Rattus norvegicus	22-27
7119733-9	1982	After inhibition of Na+-H+ exchange by mucosal perfusion with amiloride (1 mM) or by complete Na+ replacement with TMA+, phi fell reversibly by 0.15 and 0.22 pH units, respectively.	Amiloride	62-71	glucose-6-phosphate isomerase	Homo sapiens	121-124
6979542-2	1982	The diuretic amiloride, an inhibitor of Na+/H+ exchange, completely blocks EGF-induced Na+ influx, Na+,K+-pump activity, and DNA synthesis without affecting the cellular binding, visible clustering, and internalization of 125I-labeled and fluorescent EGF.	Amiloride	13-22	epidermal growth factor	Homo sapiens	75-78
6979542-2	1982	The diuretic amiloride, an inhibitor of Na+/H+ exchange, completely blocks EGF-induced Na+ influx, Na+,K+-pump activity, and DNA synthesis without affecting the cellular binding, visible clustering, and internalization of 125I-labeled and fluorescent EGF.	Amiloride	13-22	epidermal growth factor	Homo sapiens	251-254
6979542-3	1982	In the absence of EGF, the induction of amiloride-sensitive Na+ influx and Na+,K+-pump activity can be mimicked by exposing the cells to weak acids.	Amiloride	40-49	epidermal growth factor	Homo sapiens	18-21
6122211-9	1982	Guanidinium and guanidinated compounds such as amiloride or neurotensin prevent binding of 125I-labeled apamin, the best antagonist being neurotensin.	Amiloride	47-56	neurotensin	Mus musculus	138-149
730416-0	1978	Renin-aldosterone system and urinary electrolytes after amiloride, hydrochlorothiazide and the combination.	Amiloride	56-65	renin	Homo sapiens	0-5
6773984-0	1980	Amiloride inhibits mammalian renal kallikrein and a kallikrein-like enzyme from toad bladder and skin.	Amiloride	0-9	kallikrein related peptidase 4	Homo sapiens	35-45
6773984-0	1980	Amiloride inhibits mammalian renal kallikrein and a kallikrein-like enzyme from toad bladder and skin.	Amiloride	0-9	kallikrein related peptidase 4	Homo sapiens	52-62
6773984-3	1980	These facts led us to study the effects of amiloride, a drug known to inhibit sodium reabsorption and potassium secretion at this site, on kallikrein activity.	Amiloride	43-52	kallikrein related peptidase 4	Homo sapiens	139-149
6773984-4	1980	Amiloride inhibited the esterolytic activity of purified rat or human urinary kallikrein or of rat renal cortical cells upon a synthetic substrate (ID50 = 0.12-0.23 mM).	Amiloride	0-9	kallikrein related peptidase 4	Homo sapiens	78-88
6773984-6	1980	The kinin-generating activity of kallikrein acting upon kininogen substrates was also inhibited by amiloride, as measured by bioassay in the rat uterus of guinea pig ileum or by radioimmunoassay of liberated kinins (ID50 = 85 microM).	Amiloride	99-108	kallikrein related peptidase 4	Homo sapiens	33-43
6773984-8	1980	In addition, kallikrein-like enzyme activity was discovered in the urinary bladder or skin of Bufo marinus toads and this activity was also inhibited by amiloride.	Amiloride	153-162	kallikrein related peptidase 4	Homo sapiens	13-23
6989547-10	1980	It is concluded that amiloride is safe for patients with an intact renin aldosterone system, more especially those with normal renal function and diet-controlled diabetes mellitus.	Amiloride	21-30	renin	Homo sapiens	67-72
7013841-4	1981	Both the increase in intracellular pH induced by insulin and the associated increase in intracellular Na+ produced by this hormone in the presence of ouabain are blocked by amiloride.	Amiloride	173-182	insulin	Homo sapiens	49-56
7013841-7	1981	Thus, the mechanism stimulated by insulin is not a Na+-CO3(2-) cotransport system, but is either an Na:H exchange or a Na+-OH- cotransport system which can be inhibited by amiloride.	Amiloride	172-181	insulin	Homo sapiens	34-41
23428-13	1977	Amiloride (10(-4)M) reversibly reduced the rate of pH(i) recovery to much the same extent as removal of external Na.	Amiloride	0-9	glucose-6-phosphate isomerase 1	Mus musculus	51-56
418180-4	1978	However, at 0.1 to 0.5 mM, harmaline produced an increase in SCC inhibitable with amiloride.	Amiloride	82-91	serpin family B member 3	Homo sapiens	61-64
973876-2	1976	When spironolactone or amiloride replaced Slow K, distinct parallel increments in the levels of renin, angiotensin II, and aldosterone resulted.	Amiloride	23-32	renin	Homo sapiens	96-101
973876-2	1976	When spironolactone or amiloride replaced Slow K, distinct parallel increments in the levels of renin, angiotensin II, and aldosterone resulted.	Amiloride	23-32	angiotensinogen	Homo sapiens	103-117
961856-7	1976	When the changes in open-circuit voltage and shunt resistance caused by vasopressin and amiloride (as determined from the I-V relationships) were examined, the data were also found to be compatible with the idea that vasopressin exerted an influence on the shunt pathway of the frog skin, and this effect of vasopressin could be reversed by amiloride.	Amiloride	88-97	arginine vasopressin	Homo sapiens	217-228
961856-7	1976	When the changes in open-circuit voltage and shunt resistance caused by vasopressin and amiloride (as determined from the I-V relationships) were examined, the data were also found to be compatible with the idea that vasopressin exerted an influence on the shunt pathway of the frog skin, and this effect of vasopressin could be reversed by amiloride.	Amiloride	341-350	arginine vasopressin	Homo sapiens	217-228
961856-5	1976	However, with vasopressin-treated skins, amiloride at 10(-6) M decreased the sodium backflux of the shunt pathway to levels observed previously for the control skins.	Amiloride	41-50	arginine vasopressin	Homo sapiens	14-25
961856-7	1976	When the changes in open-circuit voltage and shunt resistance caused by vasopressin and amiloride (as determined from the I-V relationships) were examined, the data were also found to be compatible with the idea that vasopressin exerted an influence on the shunt pathway of the frog skin, and this effect of vasopressin could be reversed by amiloride.	Amiloride	88-97	arginine vasopressin	Homo sapiens	217-228
961856-7	1976	When the changes in open-circuit voltage and shunt resistance caused by vasopressin and amiloride (as determined from the I-V relationships) were examined, the data were also found to be compatible with the idea that vasopressin exerted an influence on the shunt pathway of the frog skin, and this effect of vasopressin could be reversed by amiloride.	Amiloride	341-350	arginine vasopressin	Homo sapiens	217-228
24173388-2	1971	In the isolated cells these changes were prevented by amiloride (10(-5) M), suggesting that the gain of sodium after vasopressin occurs across the mucosal membrane.	Amiloride	54-63	arginine vasopressin	Homo sapiens	117-128
4574908-0	1973	The importance of the guanidine group in the insulin-stimulatory effect of amiloride hydrochloride.	Amiloride	75-98	insulin	Homo sapiens	45-52
237282-0	1975	Effects of vasopressin and aldosterone on amiloride binding in toad bladder epithelial cells.	Amiloride	42-51	arginine vasopressin	Homo sapiens	11-22
4361398-0	1973	Spironolactone and amiloride in the treatment of low renin hyperaldosteronism and related syndromes.	Amiloride	19-28	renin	Homo sapiens	53-58
24173165-5	1971	On the other hand, amiloride, a diuretic thought to block specifically Na(+) entry, markedly reducedI S , without reducingE Na.It is concluded that vasopressin constitutes a probe for the rapid reproducible determination ofE Na under a wide variety of physiological conditions.	Amiloride	19-28	arginine vasopressin	Homo sapiens	148-159
5647323-5	1968	Vasopressin, cyclic adenosine monophosphate (AMP) and aldosterone increased Na transport and SCC across the bladder and these effects were inhibited by amiloride.4.	Amiloride	152-161	arginine vasopressin	Homo sapiens	0-11
5647323-6	1968	The antagonism of amiloride for vasopressin was non-competitive.5.	Amiloride	18-27	arginine vasopressin	Homo sapiens	32-43
33476055-17	2021	This hyperalgesia was reversed by both amiloride (F (1, 13) = 5.056, p = 0.0425, compared with PBS) and capsazepine (F(1, 10) = 8.402, p = 0.0159, compared with DMSO), suggesting primary afferents sensitized by the mixture express both TRPV1 and ASICs.	Amiloride	39-48	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	236-241
33949206-8	2021	These outcomes support the hypothesis that exposure to hyperoxia increases GSSG, resulting in reduced lung fluid reabsorption due to inhibition of amiloride-sensitive ENaC.	Amiloride	147-156	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	167-171
33392760-13	2021	In cultured DNPCs, significant alterations of ASIC1a levels, LDH activity, HIF-1alpha levels, and inflammatory cytokines were found under acidified condition (pH 6.0), but were prevented by amiloride.	Amiloride	190-199	hypoxia inducible factor 1 subunit alpha	Homo sapiens	75-85
33591965-9	2021	Treatment of amiloride, an ENaC inhibitor, normalizes sweat and salt excretion in corin-deficient mice.	Amiloride	13-22	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	27-31
33591965-9	2021	Treatment of amiloride, an ENaC inhibitor, normalizes sweat and salt excretion in corin-deficient mice.	Amiloride	13-22	corin, serine peptidase	Mus musculus	82-87
33517269-6	2021	The growth-inhibitory effect of sorafenib was significantly enhanced by the uPA inhibitors UK122 and amiloride.	Amiloride	101-110	plasminogen activator, urokinase	Homo sapiens	76-79
33633581-4	2021	Thus, we hypothesize that high tubular flow and FSS mediate ERK activation in the cortical collecting duct (CCD) of solitary kidney which regulates amiloride sensitive Na transport and affects CCD cell number.	Amiloride	148-157	mitogen-activated protein kinase 1	Mus musculus	60-63
33280408-6	2021	Ussing chamber technique was performed to determine amiloride-sensitive short-circuit current, an index of ENaC activity in confluent mouse cortical collecting duct cell line cells exposed for 24 hours to Ang II, Ang II + PF, or Ang II + PF + sPRR-His.	Amiloride	52-61	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	205-211
32725694-0	2021	Effect of quercetin on the amiloride-bovine serum albumin interaction using spectroscopic methods, molecular docking and chemometric approaches.	Amiloride	27-36	albumin	Homo sapiens	44-57
33219051-6	2020	Both Skn-1a and Calhm3-deficient mice have markedly decreased chorda tympani nerve responses to sodium chloride, and those decreased responses are attributed to the loss of the amiloride-sensitive salty taste response.	Amiloride	177-186	POU domain, class 2, transcription factor 3	Mus musculus	5-11
32725694-1	2021	The effect of quercetin flavonoid (QUE), on the binding interaction of antihypertensive drug, amiloride (AMI) with bovine serum albumin (BSA) was investigated in this work.	Amiloride	94-103	albumin	Homo sapiens	122-135
32725694-1	2021	The effect of quercetin flavonoid (QUE), on the binding interaction of antihypertensive drug, amiloride (AMI) with bovine serum albumin (BSA) was investigated in this work.	Amiloride	105-108	albumin	Homo sapiens	122-135
33584200-10	2020	Also, Amiloride treatment significantly reversed the expression of NKCC1 in the spinal dorsal horn of NMD rats.	Amiloride	6-15	solute carrier family 12 member 2	Rattus norvegicus	67-72
33718604-10	2021	The patient"s ACTH hypersecretion and hypokalemia were treated with potassium replacement, amiloride, and ketoconazole.	Amiloride	91-100	proopiomelanocortin	Homo sapiens	14-18
33186222-8	2021	The effect of aldosterone on pendrin expression is in part mediated by the development of hypokalemic alkalosis and blunted by K-supplements or amiloride.	Amiloride	144-153	solute carrier family 26, member 4	Mus musculus	29-36
33384439-8	2020	Furthermore, we confirmed that mildly and severely affected siblings have different ESPR2 genetic backgrounds and that ESRP2 markers are linked to the response of CF patients" nasal epithelium to amiloride, indicating ENaC involvement (Pbest = 0.0131, Pcorr = 0.068 for multiple testing).	Amiloride	196-205	epithelial splicing regulatory protein 2	Homo sapiens	119-124
33219051-5	2020	This novel cell population expresses Plcb2, Itpr3, Calhm3, Skn-1a, and ENaC alpha (also known as Scnn1a) encoding the putative amiloride-sensitive salty taste receptor, but lacks Trpm5 and Gnat3 Skn-1a-deficient taste buds are predominantly composed of putative non-sensory type I cells and sour-sensing type III cells, whereas wild-type taste buds include type II (i.e., sweet, umami, and bitter taste) cells and sodium-taste cells.	Amiloride	127-136	sodium channel epithelial 1 subunit alpha	Homo sapiens	97-103
33219051-6	2020	Both Skn-1a and Calhm3-deficient mice have markedly decreased chorda tympani nerve responses to sodium chloride, and those decreased responses are attributed to the loss of the amiloride-sensitive salty taste response.	Amiloride	177-186	calcium homeostasis modulator 3	Mus musculus	16-22
33219051-11	2020	They mediate amiloride-sensitive sodium taste and rely on Skn-1a for their generation and the CALHM ion channel for neurotransmitter release.	Amiloride	13-22	POU class 2 homeobox 3	Homo sapiens	58-64
33219051-12	2020	Amiloride-insensitive salty taste is partially mediated by sour taste cells, the only taste cells present in the Skn-1a knockout mice.	Amiloride	0-9	POU domain, class 2, transcription factor 3	Mus musculus	113-119
33070369-4	2020	We performed comparative studies in a puromycin aminonucleoside (PAN) nephropathy rat model treated with amiloride, an inhibitor of plasminogen activation, and measured changes in plasmin (ogen) uria.	Amiloride	105-114	plasminogen	Homo sapiens	132-139
33215566-10	2020	Compared with ANGII infusion alone, wild-type ANGII-infused diabetic mice showed blood pressure reduction upon amiloride treatment.	Amiloride	111-120	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	14-19
33215566-10	2020	Compared with ANGII infusion alone, wild-type ANGII-infused diabetic mice showed blood pressure reduction upon amiloride treatment.	Amiloride	111-120	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	46-51
33255506-0	2020	Failed Neuroprotection of Combined Inhibition of L-Type and ASIC1a Calcium Channels with Nimodipine and Amiloride.	Amiloride	104-113	acid-sensing (proton-gated) ion channel 1	Mus musculus	60-66
32750454-8	2020	Blocking epithelial sodium channel activity with Amiloride in Rrm2b-/- mice resulted in increased expression of its chaperone PCSK9 in the CCD, followed by elevated plasma levels and worsening hypercholesterolemia.	Amiloride	49-58	ribonucleotide reductase M2 B (TP53 inducible)	Mus musculus	62-67
32750454-8	2020	Blocking epithelial sodium channel activity with Amiloride in Rrm2b-/- mice resulted in increased expression of its chaperone PCSK9 in the CCD, followed by elevated plasma levels and worsening hypercholesterolemia.	Amiloride	49-58	proprotein convertase subtilisin/kexin type 9	Mus musculus	126-131
32878902-8	2020	"N neurons," whose NaCl responses were blocked by the amiloride analog benzamil, responded robustly to light stimulation of GAD65+ TBCs on the anterior tongue.	Amiloride	54-63	glutamic acid decarboxylase 2	Mus musculus	124-129
33239909-10	2020	Amiloride, an inhibitor of ASIC1, clearly increased the PWT of CFA rats.	Amiloride	0-9	acid sensing ion channel subunit 1	Rattus norvegicus	27-32
33208364-0	2020	Engineered mutant alpha-ENaC subunit mRNA delivered by lipid nanoparticles reduces amiloride currents in cystic fibrosis-based cell and mice models.	Amiloride	83-92	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	18-28
33208364-2	2020	Airway dehydration and impaired mucociliary clearance in CF is proposed to result in tonic epithelial sodium channel (ENaC) activity, which drives amiloride-sensitive electrogenic sodium absorption.	Amiloride	147-156	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	118-122
33208364-6	2020	We observed a significant decrease in macroscopic as well as amiloride-sensitive ENaC currents and an increase in airway surface liquid height in CF airway cells.	Amiloride	61-70	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	81-85
33116037-4	2020	Amiloride, a prototypic inhibitor of epithelial sodium channels (ENaC) can be an ideal candidate for COVID-19 patients, given its ACE reducing and cytosolic pH increasing effects.	Amiloride	0-9	angiotensin I converting enzyme	Homo sapiens	130-133
32948210-9	2020	As judged by electrophysiology experiments, TSP-1 treatment elicited an amiloride-sensitive inward current alluding to a possible Ca2+ influx via non-selective cation channels.	Amiloride	72-81	thrombospondin 1	Homo sapiens	44-49
32712714-0	2020	Transport properties in CFTR-/- knockout piglets suggest normal airway surface liquid pH and enhanced amiloride-sensitive Na+ absorption.	Amiloride	102-111	CF transmembrane conductance regulator	Homo sapiens	24-28
32712714-14	2020	In contrast, enhanced amiloride-sensitive Na+ absorption may contribute to lung pathology in CFTR-/- piglets, along with a compromised CFTR- and TMEM16A-dependent Cl- transport.	Amiloride	22-31	CF transmembrane conductance regulator	Homo sapiens	93-97
32545865-0	2020	An Inhibitor of the Sodium-Hydrogen Exchanger-1 (NHE-1), Amiloride, Reduced Zinc Accumulation and Hippocampal Neuronal Death after Ischemia.	Amiloride	57-66	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	20-47
32752278-14	2020	Dose-response curves and competition with amiloride identified CDDP as a weak inhibitor of ENaC (apparent IC50 = 1 microM) that competes with amiloride for inhibition of the channel, weakening the inhibitory actions of the latter.	Amiloride	42-51	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	91-95
32752278-14	2020	Dose-response curves and competition with amiloride identified CDDP as a weak inhibitor of ENaC (apparent IC50 = 1 microM) that competes with amiloride for inhibition of the channel, weakening the inhibitory actions of the latter.	Amiloride	142-151	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	91-95
32733209-6	2020	The electrophysiological tests results suggested that a rapid decrease in extracellular pH at the growth cones of voltage-clamped neurons elicits inward currents that were blocked by bath application of the ASIC antagonist amiloride, showing that the ASICs expressed at growth cones are functional.	Amiloride	223-232	acid sensing ion channel subunit 1	Homo sapiens	207-211
32506040-5	2020	Patch clamp and short circuit current measurements revealed that CFH inhibited the activity of amiloride-sensitive epithelial Na+ channel (ENaC) and cation sodium (Na+) channels in mouse alveolar cells and trans-epithelial Na+ transport across human airway cells with EC50 of 125 nM and 500 nM, respectively.	Amiloride	95-104	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	115-137
32506040-5	2020	Patch clamp and short circuit current measurements revealed that CFH inhibited the activity of amiloride-sensitive epithelial Na+ channel (ENaC) and cation sodium (Na+) channels in mouse alveolar cells and trans-epithelial Na+ transport across human airway cells with EC50 of 125 nM and 500 nM, respectively.	Amiloride	95-104	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	139-143
32442241-6	2020	PGE2 stimulated amiloride-sensitive ISC via basolateral prostaglandin E receptors type 4 (EP4) with an EC50 of ~7.1 nM.	Amiloride	16-25	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	90-93
32442241-12	2020	Furthermore, application of arachidonic acid also increased the amiloride-sensitive ISC involving basolateral EP4 receptors.	Amiloride	64-73	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	110-113
32107467-11	2020	Finally, we showed that pharmacological blockade of ASICs by amiloride or APETx2 significantly alleviated ET-1-induced flinching and mechanical hyperalgesia in rats.	Amiloride	61-70	endothelin 1	Rattus norvegicus	106-110
32752278-15	2020	Such observations are consistent with CDDP being a partial modulator of ENaC, which possibly has a binding site that overlaps with that of amiloride.	Amiloride	139-148	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	72-76
32545865-0	2020	An Inhibitor of the Sodium-Hydrogen Exchanger-1 (NHE-1), Amiloride, Reduced Zinc Accumulation and Hippocampal Neuronal Death after Ischemia.	Amiloride	57-66	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	49-54
32545865-7	2020	Thus, we conducted the present study to confirm whether inhibition of NHE-1 by amiloride attenuates zinc accumulation and subsequent hippocampus neuronal death following GCI.	Amiloride	79-88	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	70-75
32587517-7	2020	The effect was sensitive to amiloride (10 microM) and cariporide (5 microM), suggesting that it was mainly caused by the activity of the Na+/H+ antiporter NHE1.	Amiloride	28-37	solute carrier family 9 member A1	Homo sapiens	155-159
32497506-4	2020	(2020) report that the epithelial sodium channel ENaC, which serves as the salty receptor, is co-expressed with the voltage-activated ATP release channel CALHM1/3 in a subset of taste cells and that these cells mediate amiloride-sensitive salty taste.	Amiloride	219-228	calcium homeostasis modulator 1	Homo sapiens	154-162
32299681-10	2020	Consistently, the phenotype of collecting system-Kcnj10-knockout was fully abrogated by ENaC inhibition with amiloride and ameliorated by genetic inactivation of ROMK in the collecting system.	Amiloride	109-118	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	49-55
32229307-5	2020	Genetic elimination of ENaC in CALHM1-expressing cells as well as global CALHM3 deletion abolished amiloride-sensitive neural responses and attenuated behavioral attraction to NaCl.	Amiloride	99-108	calcium homeostasis modulator 3	Homo sapiens	73-79
32299681-10	2020	Consistently, the phenotype of collecting system-Kcnj10-knockout was fully abrogated by ENaC inhibition with amiloride and ameliorated by genetic inactivation of ROMK in the collecting system.	Amiloride	109-118	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	88-92
32264868-5	2020	Potential NHE involvement was tested with amiloride (aspecific NHE inhibitor) or cariporide (NHE1 inhibitor).	Amiloride	42-51	solute carrier family 9 member C1	Homo sapiens	10-13
32154568-2	2020	Amiloride, an epithelial Na+ channel (ENaC) blocker, consistently and significantly decreases the NaCl responsiveness of the CT but not the glossopharyngeal (GL) nerve in the rat.	Amiloride	0-9	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	38-42
32079677-10	2020	When expressed in oocytes, PON3 inhibited ENaC-mediated amiloride-sensitive Na+ currents, in part by reducing the surface expression of ENaC.	Amiloride	56-65	paraoxonase 3	Homo sapiens	27-31
32009028-1	2020	Epithelial sodium channel (ENaC) is an amiloride-sensitive sodium ion channel that is expressed in epithelial tissues.	Amiloride	39-48	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	27-31
32260115-3	2020	The diuretic drug amiloride is known to block ENaC, producing a mild natriuresis.	Amiloride	18-27	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	46-50
32190682-4	2020	We confirmed that alpha-ENaC is one of the target genes of miR-124-5p through dual luciferase assay and Ussing chamber assay revealed that miR-124-5p inhibited amiloride-sensitive currents associated with ENaC activity in intact H441 monolayers.	Amiloride	160-169	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	18-28
32221667-3	2020	Co-expression of rENaC and STX3 or STX4 in Xenopus laevis oocytes increased amiloride-sensitive whole-cell currents (DeltaIami) on average by 50% and 135%, respectively, compared to oocytes expressing rENaC alone.	Amiloride	76-85	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	17-22
32221667-3	2020	Co-expression of rENaC and STX3 or STX4 in Xenopus laevis oocytes increased amiloride-sensitive whole-cell currents (DeltaIami) on average by 50% and 135%, respectively, compared to oocytes expressing rENaC alone.	Amiloride	76-85	syntaxin 3 L homeolog	Xenopus laevis	27-31
32221667-3	2020	Co-expression of rENaC and STX3 or STX4 in Xenopus laevis oocytes increased amiloride-sensitive whole-cell currents (DeltaIami) on average by 50% and 135%, respectively, compared to oocytes expressing rENaC alone.	Amiloride	76-85	syntaxin 4 L homeolog	Xenopus laevis	35-39
31913693-6	2020	In normal SAECs, HMGB-1 increased amiloride-sensitive Isc and ENaC Po from 0.15+-0.03 to 0.28+-0.04; p<0.01.	Amiloride	34-43	high mobility group box 1	Homo sapiens	17-23
31891193-12	2020	This stimulatory effect was significantly attenuated by an increase in arterial pH generated by infusion of sodium bicarbonate (NaHCO3 ), and completely abrogated by a combined pretreatment with amiloride (an antagonist of acid-sensing ion channels, ASICs) and AMG8910 (a selective antagonist of the transient receptor potential vanilloid type-1 receptor, TRPV1).	Amiloride	195-204	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	356-361
31841392-3	2020	In cultured mpkCCD cells, administration of recombinant histidine-tagged sPRR (sPRR-His) at 10 nM within minutes induced a significant and transient increase in the amiloride-sensitive short-circuit current as assessed using the Ussing chamber technique.	Amiloride	165-174	small proline-rich protein 1A	Rattus norvegicus	73-77
31841392-3	2020	In cultured mpkCCD cells, administration of recombinant histidine-tagged sPRR (sPRR-His) at 10 nM within minutes induced a significant and transient increase in the amiloride-sensitive short-circuit current as assessed using the Ussing chamber technique.	Amiloride	165-174	small proline-rich protein 1A	Rattus norvegicus	79-83
31789848-2	2020	Recent studies from mice, rats and humans have shown that the sodium retention depends on urinary serine proteases and that it can be mitigated by blockers (amiloride, triamterene) of the epithelial sodium channel ENaC.	Amiloride	157-166	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	214-218
31891193-14	2020	In addition, inhalation of SO2 consistently evoked coughs in awake mice; responses were significantly smaller in TRPV1-/- mice than in wild-type mice, and almost completely abolished after a pretreatment with amiloride in TRPV1-/- mice.	Amiloride	209-218	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	113-118
31891193-14	2020	In addition, inhalation of SO2 consistently evoked coughs in awake mice; responses were significantly smaller in TRPV1-/- mice than in wild-type mice, and almost completely abolished after a pretreatment with amiloride in TRPV1-/- mice.	Amiloride	209-218	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	222-227
31824248-10	2019	Medium- to large-sized ASIC1b-expressing DRG neurons mainly exhibited an amiloride-sensitive ASIC-like biphasic current (I ASIC) in response to acid stimulation, whereas small- to medium-sized ASIC1b-expressing DRG neurons predominantly exhibited an amiloride-insensitive sustained current.	Amiloride	73-82	acid-sensing (proton-gated) ion channel 1	Mus musculus	23-27
31423748-0	2019	Urokinase-type plasminogen activator contributes to amiloride-sensitive sodium retention in nephrotic range glomerular proteinuria in mice.	Amiloride	52-61	plasminogen activator, urokinase	Mus musculus	0-36
31423748-7	2019	Amiloride treatment in podocin-deficient mice resulted in weight loss, increased sodium excretion, normalization of sodium balance and prevention of the activation of plasminogen to plasmin in urine in a reversible way.	Amiloride	0-9	nephrosis 2, podocin	Mus musculus	23-30
31679971-0	2019	6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease.	Amiloride	0-23	plasminogen activator, urokinase	Rattus norvegicus	57-93
31679971-3	2019	In applying the selective optimization of side-activity (SOSA) approach, a focused library of twenty two 6-substituted amiloride derivatives were prepared, with multiple examples displaying uPA inhibitory potencies in the nM range.	Amiloride	119-128	plasminogen activator, urokinase	Rattus norvegicus	190-193
31679971-4	2019	X-ray co-crystal structures revealed that the potency increases relative to amiloride arise from increased occupancy of uPA"s S1beta subsite by the appended 6-substituents.	Amiloride	76-85	plasminogen activator, urokinase	Rattus norvegicus	120-123
31006168-3	2019	METHODS: Activation of amiloride-sensitive currents by uPA and plg were studied in Xenopus laevis oocytes expressing murine ENaC.	Amiloride	23-32	plasminogen activator, urokinase	Mus musculus	55-58
31006168-3	2019	METHODS: Activation of amiloride-sensitive currents by uPA and plg were studied in Xenopus laevis oocytes expressing murine ENaC.	Amiloride	23-32	plasminogen	Mus musculus	63-66
31006168-3	2019	METHODS: Activation of amiloride-sensitive currents by uPA and plg were studied in Xenopus laevis oocytes expressing murine ENaC.	Amiloride	23-32	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	124-128
31006168-4	2019	In doxorubicin-induced nephrotic mice, uPA was inhibited pharmacologically by amiloride and genetically by the use of uPA-deficient mice (uPA-/- ).	Amiloride	78-87	plasminogen activator, urokinase	Mus musculus	39-42
31006168-5	2019	RESULTS: Experiments in Xenopus laevis oocytes expressing murine ENaC confirmed proteolytic ENaC activation by a combination of plg and uPA which stimulated amiloride-sensitive currents with concomitant cleavage of the ENaC gamma-subunit at the cell surface.	Amiloride	157-166	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	65-69
31006168-5	2019	RESULTS: Experiments in Xenopus laevis oocytes expressing murine ENaC confirmed proteolytic ENaC activation by a combination of plg and uPA which stimulated amiloride-sensitive currents with concomitant cleavage of the ENaC gamma-subunit at the cell surface.	Amiloride	157-166	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	92-96
31006168-5	2019	RESULTS: Experiments in Xenopus laevis oocytes expressing murine ENaC confirmed proteolytic ENaC activation by a combination of plg and uPA which stimulated amiloride-sensitive currents with concomitant cleavage of the ENaC gamma-subunit at the cell surface.	Amiloride	157-166	plasminogen	Mus musculus	128-131
31006168-5	2019	RESULTS: Experiments in Xenopus laevis oocytes expressing murine ENaC confirmed proteolytic ENaC activation by a combination of plg and uPA which stimulated amiloride-sensitive currents with concomitant cleavage of the ENaC gamma-subunit at the cell surface.	Amiloride	157-166	plasminogen activator, urokinase	Mus musculus	136-139
31006168-5	2019	RESULTS: Experiments in Xenopus laevis oocytes expressing murine ENaC confirmed proteolytic ENaC activation by a combination of plg and uPA which stimulated amiloride-sensitive currents with concomitant cleavage of the ENaC gamma-subunit at the cell surface.	Amiloride	157-166	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	92-96
31006168-6	2019	Treatment of nephrotic wild-type mice with amiloride inhibited urinary uPA activity, prevented urinary plasmin formation and sodium retention.	Amiloride	43-52	plasminogen activator, urokinase	Mus musculus	71-74
31006168-9	2019	Amiloride prevented sodium retention in nephrotic uPA-/- mice which confirmed the critical role of ENaC in sodium retention.	Amiloride	0-9	plasminogen activator, urokinase	Mus musculus	50-53
31006168-9	2019	Amiloride prevented sodium retention in nephrotic uPA-/- mice which confirmed the critical role of ENaC in sodium retention.	Amiloride	0-9	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	99-103
31617909-6	2019	Our data further indicate that: 1) estrogen signaling through estrogen receptor alpha (ERalpha) increases EnNaC activity to a larger extent in females compared to males, 2) estrogen-induced activation of EnNaC is mediated by the serum glucocorticoid inducible-kinase 1 (SGK-1), and 3) estrogen signaling stiffens endothelial cells when nitric oxide is lacking and this stiffening effect can be reduced with amiloride, an ENaC inhibitor.	Amiloride	407-416	estrogen receptor 1 (alpha)	Mus musculus	62-85
31617909-6	2019	Our data further indicate that: 1) estrogen signaling through estrogen receptor alpha (ERalpha) increases EnNaC activity to a larger extent in females compared to males, 2) estrogen-induced activation of EnNaC is mediated by the serum glucocorticoid inducible-kinase 1 (SGK-1), and 3) estrogen signaling stiffens endothelial cells when nitric oxide is lacking and this stiffening effect can be reduced with amiloride, an ENaC inhibitor.	Amiloride	407-416	estrogen receptor 1 (alpha)	Mus musculus	87-94
31617909-6	2019	Our data further indicate that: 1) estrogen signaling through estrogen receptor alpha (ERalpha) increases EnNaC activity to a larger extent in females compared to males, 2) estrogen-induced activation of EnNaC is mediated by the serum glucocorticoid inducible-kinase 1 (SGK-1), and 3) estrogen signaling stiffens endothelial cells when nitric oxide is lacking and this stiffening effect can be reduced with amiloride, an ENaC inhibitor.	Amiloride	407-416	serum/glucocorticoid regulated kinase 1	Mus musculus	229-268
31824248-10	2019	Medium- to large-sized ASIC1b-expressing DRG neurons mainly exhibited an amiloride-sensitive ASIC-like biphasic current (I ASIC) in response to acid stimulation, whereas small- to medium-sized ASIC1b-expressing DRG neurons predominantly exhibited an amiloride-insensitive sustained current.	Amiloride	73-82	acid-sensing (proton-gated) ion channel 1	Mus musculus	93-97
31299476-7	2019	Reversely, inhibition of NHX1 by amiloride treatment, enhanced Cd2+ influx in NHX1 duckweed, subsequently delayed Cd2+ efflux in both genotypes of duckweed under Cd2+ shock.	Amiloride	33-42	CD2 molecule	Homo sapiens	63-66
31299476-7	2019	Reversely, inhibition of NHX1 by amiloride treatment, enhanced Cd2+ influx in NHX1 duckweed, subsequently delayed Cd2+ efflux in both genotypes of duckweed under Cd2+ shock.	Amiloride	33-42	CD2 molecule	Homo sapiens	114-117
31299476-7	2019	Reversely, inhibition of NHX1 by amiloride treatment, enhanced Cd2+ influx in NHX1 duckweed, subsequently delayed Cd2+ efflux in both genotypes of duckweed under Cd2+ shock.	Amiloride	33-42	CD2 molecule	Homo sapiens	114-117
31061124-10	2019	Accumulation of the transcriptional activator beta-catenin in the nucleus of SW480 cells was inhibited by methyltransferase inhibition, EIPA, or the diuretic amiloride.	Amiloride	158-167	catenin beta 1	Homo sapiens	46-58
31546789-3	2019	We previously revealed that circulating AngII suppresses amiloride-sensitive salt taste responses and enhances the responses to sweet compounds via the AngII type 1 receptor (AT1) expressed in taste cells.	Amiloride	57-66	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	40-45
31349755-7	2019	Cytochalasin D and amiloride treatment of differentiated THP-1 cells reduced cell-associated MWCNTs and IL-8 induction.	Amiloride	19-28	C-X-C motif chemokine ligand 8	Homo sapiens	104-108
30969802-12	2019	The hypernatremia and hypokalemia in MST3-/- mice were significantly reversed by the ENaC inhibitor amiloride, indicating that MST3-/- mice reabsorbed more Na+ through ENaC.	Amiloride	100-109	serine/threonine kinase 24	Mus musculus	37-41
30969802-12	2019	The hypernatremia and hypokalemia in MST3-/- mice were significantly reversed by the ENaC inhibitor amiloride, indicating that MST3-/- mice reabsorbed more Na+ through ENaC.	Amiloride	100-109	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	85-89
30969802-12	2019	The hypernatremia and hypokalemia in MST3-/- mice were significantly reversed by the ENaC inhibitor amiloride, indicating that MST3-/- mice reabsorbed more Na+ through ENaC.	Amiloride	100-109	serine/threonine kinase 24	Mus musculus	127-131
30969802-12	2019	The hypernatremia and hypokalemia in MST3-/- mice were significantly reversed by the ENaC inhibitor amiloride, indicating that MST3-/- mice reabsorbed more Na+ through ENaC.	Amiloride	100-109	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	168-172
31655555-9	2019	Treatment with amiloride of proband and his sister did not normalize the blood pressure, but normalized level of plasma renin activity.	Amiloride	15-24	renin	Homo sapiens	120-125
31368174-6	2019	Detailed analysis of Nphs2 pod during early sodium retention, revealed increased expression of full-length ENaC subunits and alphaENaC cleavage product with concomitant increase in ENaC activity as tested by amiloride application, and augmented collecting duct Na+ /K+ -ATPase expression.	Amiloride	208-217	NPHS2 stomatin family member, podocin	Homo sapiens	21-26
31152681-6	2019	We found that 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxamide (BS008) can regulate AS of apoptotic gene transcripts, including HIPK3, SMAC, and BCL-X, at a lower concentration than amiloride.	Amiloride	217-226	homeodomain interacting protein kinase 3	Homo sapiens	163-168
31152681-6	2019	We found that 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxamide (BS008) can regulate AS of apoptotic gene transcripts, including HIPK3, SMAC, and BCL-X, at a lower concentration than amiloride.	Amiloride	217-226	diablo IAP-binding mitochondrial protein	Homo sapiens	170-174
31152681-6	2019	We found that 3,5-diamino-6-chloro-N-(N-(2,6-dichlorobenzoyl)carbamimidoyl)pyrazine-2-carboxamide (BS008) can regulate AS of apoptotic gene transcripts, including HIPK3, SMAC, and BCL-X, at a lower concentration than amiloride.	Amiloride	217-226	BCL2 like 1	Homo sapiens	180-185
31119982-4	2019	Rapid application of solutions buffered at pH 6.7, 6.0, or 5.0 triggered rapidly activating and slowly inactivating voltage-independent inward current that reversed at voltages positive to ENa, was suppressed by 5 muM amiloride and withdrawal of [Na+]o, like neuronal ASIC currents.	Amiloride	218-227	acid sensing ion channel subunit 1	Homo sapiens	268-272
30995314-5	2019	Amiloride was used to inhibit urokinase plasminogen activator (uPA) in Plat KO mice, and outflow facility was measured.	Amiloride	0-9	plasminogen activator, urokinase	Mus musculus	30-61
31068571-9	2019	Amiloride (Ami), an NHE1 inhibitor, significantly reversed the decrease in sucrose consumption and reduction in immobility time in the TST and FST induced by LPS challenge.	Amiloride	0-9	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	20-24
31068571-9	2019	Amiloride (Ami), an NHE1 inhibitor, significantly reversed the decrease in sucrose consumption and reduction in immobility time in the TST and FST induced by LPS challenge.	Amiloride	0-3	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	20-24
31068571-10	2019	Furthermore, Ami decreased the expression of ROCK2, NHE1, calpain1, and caspase-3 and increased the Bcl-1/Bax ratio in the hippocampus of LPS-challenged mice.	Amiloride	13-16	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	45-50
31068571-10	2019	Furthermore, Ami decreased the expression of ROCK2, NHE1, calpain1, and caspase-3 and increased the Bcl-1/Bax ratio in the hippocampus of LPS-challenged mice.	Amiloride	13-16	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	52-56
31068571-10	2019	Furthermore, Ami decreased the expression of ROCK2, NHE1, calpain1, and caspase-3 and increased the Bcl-1/Bax ratio in the hippocampus of LPS-challenged mice.	Amiloride	13-16	calpain 1	Mus musculus	58-66
31068571-10	2019	Furthermore, Ami decreased the expression of ROCK2, NHE1, calpain1, and caspase-3 and increased the Bcl-1/Bax ratio in the hippocampus of LPS-challenged mice.	Amiloride	13-16	caspase 3	Mus musculus	72-81
31068571-10	2019	Furthermore, Ami decreased the expression of ROCK2, NHE1, calpain1, and caspase-3 and increased the Bcl-1/Bax ratio in the hippocampus of LPS-challenged mice.	Amiloride	13-16	cyclin D1	Mus musculus	100-105
31068571-10	2019	Furthermore, Ami decreased the expression of ROCK2, NHE1, calpain1, and caspase-3 and increased the Bcl-1/Bax ratio in the hippocampus of LPS-challenged mice.	Amiloride	13-16	BCL2-associated X protein	Mus musculus	106-109
30995314-5	2019	Amiloride was used to inhibit urokinase plasminogen activator (uPA) in Plat KO mice, and outflow facility was measured.	Amiloride	0-9	plasminogen activator, tissue	Mus musculus	71-75
30995314-9	2019	Amiloride inhibition of uPA activity prevented the TA-induced outflow facility reduction in Plat KO mice.	Amiloride	0-9	plasminogen activator, urokinase	Mus musculus	24-27
30995314-5	2019	Amiloride was used to inhibit urokinase plasminogen activator (uPA) in Plat KO mice, and outflow facility was measured.	Amiloride	0-9	plasminogen activator, urokinase	Mus musculus	63-66
30995314-9	2019	Amiloride inhibition of uPA activity prevented the TA-induced outflow facility reduction in Plat KO mice.	Amiloride	0-9	plasminogen activator, tissue	Mus musculus	92-96
29172994-1	2019	BACKGROUND: Recent basic and clinical evidence suggests amiloride may be neuroprotective in multiple sclerosis (MS) through the blockade of the acid sensing ion channel (ASIC).	Amiloride	56-65	acid sensing ion channel subunit 1	Homo sapiens	144-168
30833152-18	2019	CONCLUSION: Amiloride reduces in vitro CC contractility and enhances erectile function after oral and intraperitoneal administration, possibly via inhibition of ENaC.	Amiloride	12-21	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	161-165
30316647-8	2019	HG activated NHE1 and increased pHi value in a time-dependent manner, associated with the decreased phosphorylations of both Akt and Gridin, while inhibition of NHE1 by amiloride abolished the HG-induced reductions of p-Akt and p-Girdin.	Amiloride	169-178	solute carrier family 9 member A1	Homo sapiens	13-17
30316647-8	2019	HG activated NHE1 and increased pHi value in a time-dependent manner, associated with the decreased phosphorylations of both Akt and Gridin, while inhibition of NHE1 by amiloride abolished the HG-induced reductions of p-Akt and p-Girdin.	Amiloride	169-178	solute carrier family 9 member A1	Homo sapiens	161-165
30316647-8	2019	HG activated NHE1 and increased pHi value in a time-dependent manner, associated with the decreased phosphorylations of both Akt and Gridin, while inhibition of NHE1 by amiloride abolished the HG-induced reductions of p-Akt and p-Girdin.	Amiloride	169-178	AKT serine/threonine kinase 1	Homo sapiens	220-223
30316647-8	2019	HG activated NHE1 and increased pHi value in a time-dependent manner, associated with the decreased phosphorylations of both Akt and Gridin, while inhibition of NHE1 by amiloride abolished the HG-induced reductions of p-Akt and p-Girdin.	Amiloride	169-178	coiled-coil domain containing 88A	Homo sapiens	230-236
29172994-1	2019	BACKGROUND: Recent basic and clinical evidence suggests amiloride may be neuroprotective in multiple sclerosis (MS) through the blockade of the acid sensing ion channel (ASIC).	Amiloride	56-65	acid sensing ion channel subunit 1	Homo sapiens	170-174
31018202-2	2019	Mutations in the genes encoding the amiloride-sensitive epithelial sodium channel, ENaC, account for genetic causes of systemic PHA1.	Amiloride	36-45	sodium channel epithelial 1 subunit gamma	Homo sapiens	128-132
30425100-7	2019	Photoaffinity-labeling experiments revealed that amiloride-type inhibitors bind to the interfacial domain of multiple core subunits (49 kDa, ND1, and PSST) and the 39-kDa supernumerary subunit, although the latter does not make up the channel cavity in the current models.	Amiloride	49-58	NADH dehydrogenase subunit 1	Bos taurus	141-144
29580127-8	2019	Amiloride reduced SBP and DBP to below baseline levels in NT (p < 0.05) and HT (p < 0.001) subjects.	Amiloride	0-9	selenium binding protein 1	Homo sapiens	18-21
29580127-8	2019	Amiloride reduced SBP and DBP to below baseline levels in NT (p < 0.05) and HT (p < 0.001) subjects.	Amiloride	0-9	D-box binding PAR bZIP transcription factor	Homo sapiens	26-29
31272354-0	2019	Amiloride alleviates neurological deficits following transient global ischemia and engagement of central IL-6 and TNF-alpha signal.	Amiloride	0-9	interleukin 6	Rattus norvegicus	105-109
31272354-0	2019	Amiloride alleviates neurological deficits following transient global ischemia and engagement of central IL-6 and TNF-alpha signal.	Amiloride	0-9	tumor necrosis factor	Rattus norvegicus	114-123
31272354-7	2019	Infusion of amiloride into the lateral ventricle attenuated upregulation of Caspase-3/Caspase-9 and this further improved neurological severity score and brain edema.	Amiloride	12-21	caspase 3	Rattus norvegicus	76-85
31272354-7	2019	Infusion of amiloride into the lateral ventricle attenuated upregulation of Caspase-3/Caspase-9 and this further improved neurological severity score and brain edema.	Amiloride	12-21	caspase 9	Rattus norvegicus	86-95
30291941-6	2019	Mechanistically, CaMKKbeta/ERK pathway was activated in HSC-T6 after stimulation with high glucose and PDGF, and could be suppressed by Amiloride.	Amiloride	136-145	calcium/calmodulin-dependent protein kinase kinase 2	Rattus norvegicus	17-26
30159312-9	2018	The NaCl-induced effect was blocked by the ENaC inhibitor amiloride (IC50 = 0.47 muM).	Amiloride	58-67	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	43-47
30627552-0	2018	Amelioration of Lipopolysaccharide-Induced Acute Lung Injury in Rats by Na-H Exchanger-1 Inhibitor Amiloride Is Associated with Reversal of ERK Mitogen-Activated Protein Kinase.	Amiloride	99-108	solute carrier family 9 member A1	Rattus norvegicus	72-88
30627552-0	2018	Amelioration of Lipopolysaccharide-Induced Acute Lung Injury in Rats by Na-H Exchanger-1 Inhibitor Amiloride Is Associated with Reversal of ERK Mitogen-Activated Protein Kinase.	Amiloride	99-108	Eph receptor B1	Rattus norvegicus	140-143
30627552-3	2018	Amiloride, an inhibitor of NHE-1, inhibits the activation of macrophages and endothelial cells and reduces their production of cytokines.	Amiloride	0-9	solute carrier family 9 member A1	Rattus norvegicus	27-32
30627552-13	2018	Results: Pretreatment with amiloride significantly reduced the increase in W/D, ALI score, lung tissue MPO activity, concentrations of TP, TNF-alpha, and MIP-2 in BALF, resulting in attenuation of ALI induced by LPS.	Amiloride	27-36	myeloperoxidase	Rattus norvegicus	103-106
30627552-13	2018	Results: Pretreatment with amiloride significantly reduced the increase in W/D, ALI score, lung tissue MPO activity, concentrations of TP, TNF-alpha, and MIP-2 in BALF, resulting in attenuation of ALI induced by LPS.	Amiloride	27-36	tumor necrosis factor	Rattus norvegicus	139-148
30627552-13	2018	Results: Pretreatment with amiloride significantly reduced the increase in W/D, ALI score, lung tissue MPO activity, concentrations of TP, TNF-alpha, and MIP-2 in BALF, resulting in attenuation of ALI induced by LPS.	Amiloride	27-36	C-X-C motif chemokine ligand 2	Rattus norvegicus	154-159
30627552-15	2018	Conclusions: These findings suggest that NHE-1 inhibitor amiloride could attenuate ALI induced by LPS in rats.	Amiloride	57-66	solute carrier family 9 member A1	Rattus norvegicus	41-46
30120716-0	2018	The Heptahelical Domain of the Sweet Taste Receptor T1R2 Is a New Allosteric Binding Site for the Sweet Taste Modulator Amiloride That Modulates Sweet Taste in a Species-Dependent Manner.	Amiloride	120-129	taste 1 receptor member 2	Homo sapiens	52-56
30120716-6	2018	Compared to the sweet inhibitor lactisole (which acts on T1R3), amiloride has a different allosteric binding site on the sweet receptor, which is important new information for the design of novel sweet taste modulators that act on T1R2.	Amiloride	64-73	taste 1 receptor member 2	Homo sapiens	231-235
30272672-4	2018	The test allows the measurement of the stable baseline voltage and the successive net voltage changes after perfusion of 100 microM amiloride, an inhibitor of Na+ reabsorption in Ringer"s solution; a chloride-free solution containing amiloride to drive chloride secretion and 10 microM isoproterenol in a chloride-free solution with amiloride to stimulate the cyclic adenosine monophosphate (cAMP)-dependent chloride conductance related to CFTR.	Amiloride	132-141	CF transmembrane conductance regulator	Homo sapiens	440-444
30079481-2	2018	Amiloride, a non-specific ASIC blocker, has been shown to exert beneficial effects in animal models of migraine and in patients.	Amiloride	0-9	acid sensing ion channel subunit 1	Homo sapiens	26-30
30056252-6	2018	Both Spironolactone and eplerenone significantly increased endothelial arginine transport, an effect which was further augmented by co-incubation with aldosterone, and blunted by either silencing of MCR or co-administration of amiloride.	Amiloride	227-236	nuclear receptor subfamily 3 group C member 2	Homo sapiens	199-202
30386244-13	2018	A specific macropinocytosis inhibitor, amiloride, completely inhibits the cytosolic delivery of Rapa from FAF.	Amiloride	39-48	ubiquitin specific peptidase 9 X-linked	Homo sapiens	106-109
29328476-2	2018	Amiloride, a synthetic inhibitor of urokinase plasminogen activator (uPA), is involved in these events.	Amiloride	0-9	plasminogen activator, urokinase	Homo sapiens	36-67
29743244-5	2018	This response was enhanced by Cys substitutions at selected MEC-4 sites (Phe715, Gly716, Gln718, and Leu719) between the degenerin and the putative amiloride-binding sites in this subunit.	Amiloride	148-157	Degenerin mec-4	Caenorhabditis elegans	60-65
29743244-6	2018	In contrast, the LSS response was largely blunted in MEC-10 variants bearing single Cys substitutions in the regions preceding and following the amiloride-binding site (Gly677-Leu681), as well as with four MEC-10 touch-deficient mutations that introduced charged residues into the TM2 domain.	Amiloride	145-154	Degenerin mec-10	Caenorhabditis elegans	53-59
29413762-5	2018	The product of the SCNN1A gene ENaC can be pharmacologically inhibited with amiloride, a drug that has been used clinically for close to 50 years.	Amiloride	76-85	sodium channel epithelial 1 subunit alpha	Homo sapiens	19-25
29413762-6	2018	Amiloride inhibited growth of ASCL1-dependent SCLC more strongly than ASCL1-independent SCLC in vitro and slowed growth of ASCL1-driven SCLC in xenografts.	Amiloride	0-9	achaete-scute family bHLH transcription factor 1	Homo sapiens	30-35
29251736-10	2018	Amiloride (ENaC) and hydrochlorothiazide (pendrin inhibitor) equally attenuated the effect of PGE2 on sodium transport.	Amiloride	0-9	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	11-15
30074209-6	2018	The non-specific ASICs inhibitor amiloride and specific homomeric ASICla blocker PcTxl reduced the production of iNOS and COX-2 by LPS-induced activating RAW 264.7 cells.	Amiloride	33-42	nitric oxide synthase 2, inducible	Mus musculus	113-117
30074209-6	2018	The non-specific ASICs inhibitor amiloride and specific homomeric ASICla blocker PcTxl reduced the production of iNOS and COX-2 by LPS-induced activating RAW 264.7 cells.	Amiloride	33-42	cytochrome c oxidase II, mitochondrial	Mus musculus	122-127
29939487-5	2018	Addition of amiloride (5 mg/day) to treatment resulted in resolution of edema, weight loss of 7 kg, reduction in blood pressure (150/100-125/81 mmHg), increased 24 h urinary sodium excretion (127-165 mmol/day), decreased eGFR (41-29 mL/min), and increased plasma potassium concentration (4.6-7.8 mmol/L).	Amiloride	12-21	epidermal growth factor receptor	Homo sapiens	221-225
29397423-8	2018	Inactivation of the putative phosphorylation sites by mutating both threonine residues to alanine (betaT613A/gammaT623A) increased ENaC-mediated amiloride-sensitive whole-cell currents (DeltaIami) and expression of betaENaC at the cell surface.	Amiloride	145-154	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	131-135
29328476-2	2018	Amiloride, a synthetic inhibitor of urokinase plasminogen activator (uPA), is involved in these events.	Amiloride	0-9	plasminogen activator, urokinase	Homo sapiens	69-72
29328476-5	2018	The results of RT-qPCR demonstrated that the mRNA expression of uPA and MMP-2 in HeLa cells was downregulated significantly in a dose-dependent manner when incubated with various concentrations of amiloride for 24 h. The migration distance of HeLa cells was significantly shorter at 6, 12 and 24 h following incubation with amiloride (P&lt;0.01), and there was a positive correlation between cell migratory ability and cellular uPA protein expression level (r=0.955, P&lt;0.01).	Amiloride	197-206	plasminogen activator, urokinase	Homo sapiens	64-67
29328476-5	2018	The results of RT-qPCR demonstrated that the mRNA expression of uPA and MMP-2 in HeLa cells was downregulated significantly in a dose-dependent manner when incubated with various concentrations of amiloride for 24 h. The migration distance of HeLa cells was significantly shorter at 6, 12 and 24 h following incubation with amiloride (P&lt;0.01), and there was a positive correlation between cell migratory ability and cellular uPA protein expression level (r=0.955, P&lt;0.01).	Amiloride	197-206	matrix metallopeptidase 2	Homo sapiens	72-77
29328476-5	2018	The results of RT-qPCR demonstrated that the mRNA expression of uPA and MMP-2 in HeLa cells was downregulated significantly in a dose-dependent manner when incubated with various concentrations of amiloride for 24 h. The migration distance of HeLa cells was significantly shorter at 6, 12 and 24 h following incubation with amiloride (P&lt;0.01), and there was a positive correlation between cell migratory ability and cellular uPA protein expression level (r=0.955, P&lt;0.01).	Amiloride	197-206	plasminogen activator, urokinase	Homo sapiens	428-431
29328476-5	2018	The results of RT-qPCR demonstrated that the mRNA expression of uPA and MMP-2 in HeLa cells was downregulated significantly in a dose-dependent manner when incubated with various concentrations of amiloride for 24 h. The migration distance of HeLa cells was significantly shorter at 6, 12 and 24 h following incubation with amiloride (P&lt;0.01), and there was a positive correlation between cell migratory ability and cellular uPA protein expression level (r=0.955, P&lt;0.01).	Amiloride	324-333	plasminogen activator, urokinase	Homo sapiens	64-67
29328476-5	2018	The results of RT-qPCR demonstrated that the mRNA expression of uPA and MMP-2 in HeLa cells was downregulated significantly in a dose-dependent manner when incubated with various concentrations of amiloride for 24 h. The migration distance of HeLa cells was significantly shorter at 6, 12 and 24 h following incubation with amiloride (P&lt;0.01), and there was a positive correlation between cell migratory ability and cellular uPA protein expression level (r=0.955, P&lt;0.01).	Amiloride	324-333	matrix metallopeptidase 2	Homo sapiens	72-77
29328476-6	2018	The number of HeLa cells that penetrated the Matrigel following incubation for 24 h with different concentrations of amiloride decreased significantly compared with the control group, indicating that cell invasiveness was positively correlated with the protein expression level of uPA in the cells (r=0.993, P&lt;0.01).	Amiloride	117-126	plasminogen activator, urokinase	Homo sapiens	281-284
29328476-7	2018	The present study demonstrated that amiloride was able to specifically inhibit the mRNA expression levels of uPA in HeLa cells, and sequentially downregulate the mRNA expression of downstream MMP-2 in the uPA system, thereby suppressing the migratory and invasive ability of HeLa cells.	Amiloride	36-45	plasminogen activator, urokinase	Homo sapiens	109-112
29328476-7	2018	The present study demonstrated that amiloride was able to specifically inhibit the mRNA expression levels of uPA in HeLa cells, and sequentially downregulate the mRNA expression of downstream MMP-2 in the uPA system, thereby suppressing the migratory and invasive ability of HeLa cells.	Amiloride	36-45	matrix metallopeptidase 2	Homo sapiens	192-197
29328476-7	2018	The present study demonstrated that amiloride was able to specifically inhibit the mRNA expression levels of uPA in HeLa cells, and sequentially downregulate the mRNA expression of downstream MMP-2 in the uPA system, thereby suppressing the migratory and invasive ability of HeLa cells.	Amiloride	36-45	plasminogen activator, urokinase	Homo sapiens	205-208
29229646-8	2018	Using this approach, we show that the t-system of fast-twitch skeletal fibers displays amiloride-sensitive Na+/H+ exchange (NHE), which decreases markedly at alkaline cytosolic pH and has properties similar to that in mammalian cardiac myocytes.	Amiloride	87-96	solute carrier family 9 member C1	Homo sapiens	107-122
29229646-8	2018	Using this approach, we show that the t-system of fast-twitch skeletal fibers displays amiloride-sensitive Na+/H+ exchange (NHE), which decreases markedly at alkaline cytosolic pH and has properties similar to that in mammalian cardiac myocytes.	Amiloride	87-96	solute carrier family 9 member C1	Homo sapiens	124-127
28656379-9	2017	Amiloride, a potassium-sparing diuretic, inhibits urokinase and plasmin activation in the tubular fluid and uPAR expression in vitro, which highlights new indications for an old drug.	Amiloride	0-9	plasminogen activator, urokinase receptor	Rattus norvegicus	108-112
29042083-4	2018	Treatment of nephrotic mice with the serine protease inhibitor aprotinin by means of subcutaneous sustained-release pellets normalized urinary serine protease activity and prevented sodium retention, as did treatment with the ENaC inhibitor amiloride.	Amiloride	241-250	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	226-230
28862701-5	2017	Importantly, we demonstrate that the extent of kidney injury can be partially therapeutically ameliorated in mice with nephron-specific deletions of Nedd4-2 by blocking ENaC with amiloride.	Amiloride	179-188	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	149-156
28862701-5	2017	Importantly, we demonstrate that the extent of kidney injury can be partially therapeutically ameliorated in mice with nephron-specific deletions of Nedd4-2 by blocking ENaC with amiloride.	Amiloride	179-188	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	169-173
30175793-0	2018	[6]-Gingerol Induces Amiloride-Sensitive Sodium Absorption in the Rat Colon via the Capsaicin Receptor TRPV1 in Colonic Mucosa.	Amiloride	21-30	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	84-102
30175793-0	2018	[6]-Gingerol Induces Amiloride-Sensitive Sodium Absorption in the Rat Colon via the Capsaicin Receptor TRPV1 in Colonic Mucosa.	Amiloride	21-30	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	103-108
30175793-10	2018	These results suggest that [6]-gingerol induces amiloride-sensitive electrogenic sodium absorption in the rat colon via TRPV1 expressed in the colonic mucosal epithelium, and that this effect is independent of TRPV1 in the colonic muscle layer.	Amiloride	48-57	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	120-125
28972182-10	2017	uPA-knock-out mice developed fewer and smaller TSC2-null lung tumors, and introduction of uPA shRNA in tumor cells or amiloride-induced uPA inhibition reduced tumorigenesis in vivo These findings suggest that interference with the uPA-dependent pathway, when used along with rapamycin, might attenuate LAM progression and potentially other TSC-related disorders.	Amiloride	118-127	TSC complex subunit 1	Mus musculus	47-50
29032204-10	2017	Furthermore, preincubation of tissues for 15 min with forskolin, a cAMP activator, markedly blocked the Isc evoked by AngII, while intracellular Ca2+ pump inhibitor thapsigargin, L-type Ca2+ channel blocker nicadipine or the epithelial Na+ channel blocker amiloride didn"t show such function.	Amiloride	256-265	angiotensinogen	Rattus norvegicus	118-123
28978526-6	2017	Addition of amiloride, a specific blocker of the epithelial sodium channel (ENaC), abolished basal ion transport in both inversin knockdown and control cells, indicating ENaC involvement.	Amiloride	12-21	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	76-80
28978526-6	2017	Addition of amiloride, a specific blocker of the epithelial sodium channel (ENaC), abolished basal ion transport in both inversin knockdown and control cells, indicating ENaC involvement.	Amiloride	12-21	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	170-174
28790111-8	2017	Although amiloride was able to induce apoptosis in myeloma cells lacking p53 expression, activation of p53 signaling was observed in wild-type and mutated TP53 cells after amiloride exposure.	Amiloride	172-181	transformation related protein 53	Mus musculus	103-106
28790111-9	2017	On the other hand, we did not find a significant systemic toxicity in mice treated with amiloride.Conclusions: Overall, our results demonstrate the antimyeloma activity of amiloride and provide a mechanistic rationale for its use as an alternative treatment option for relapsed multiple myeloma patients, especially those with 17p deletion or TP53 mutations that are resistant to current therapies.	Amiloride	172-181	tumor protein p53	Homo sapiens	343-347
28481660-9	2017	Removing ENaC from the membrane with SPX-101 causes a significant decrease in amiloride-sensitive current.	Amiloride	78-87	spexin hormone	Mus musculus	37-40
28802647-0	2017	Pharmacological modulation of Acid-Sensing Ion Channels 1a and 3 by amiloride and 2-guanidine-4-methylquinazoline (GMQ).	Amiloride	68-77	acid sensing ion channel subunit 3	Homo sapiens	30-64
28802647-2	2017	Here, we compare the pharmacological modulation of ASIC1a and ASIC3 channels by amiloride and 2-guanidine-4-methylquinazoline (GMQ), two compounds commonly used for their in vitro and in vivo investigation.	Amiloride	80-89	acid sensing ion channel subunit 3	Homo sapiens	62-67
28802647-5	2017	The extracellular domain explains the pharmacological potentiating effect of amiloride and GMQ on the window current in ASIC3, and why these compounds failed to generate a window current in ASIC1a.	Amiloride	77-86	acid sensing ion channel subunit 3	Homo sapiens	120-125
28895869-0	2017	Amiloride interferes with platelet- activating factor-induced respiratory burst and MMP-9 release in bovine neutrophils independent of Na+/H+ exchanger 1.	Amiloride	0-9	matrix metallopeptidase 9	Bos taurus	84-89
28895869-2	2017	In these cells, chemotaxis and reactive oxygen species (ROS) production are reduced by the use of Na+/H+ exchanger (NHE-1) inhibitors, but these results are mainly obtained using amiloride, a non-selective NHE-1 inhibitor.	Amiloride	179-188	sodium/hydrogen exchanger 1	Bos taurus	116-121
28895869-2	2017	In these cells, chemotaxis and reactive oxygen species (ROS) production are reduced by the use of Na+/H+ exchanger (NHE-1) inhibitors, but these results are mainly obtained using amiloride, a non-selective NHE-1 inhibitor.	Amiloride	179-188	sodium/hydrogen exchanger 1	Bos taurus	206-211
28895869-4	2017	The aim of this study was to determine the role of NHE-1 using amiloride and zoniporide in pH regulation, ROS production, matrix metalloproteinase 9 (MMP-9) release and calcium flux in bovine PMNs induced by the platelet activation factor (PAF), additionally we evaluated the presence of NHE-1 and NHE-2 mRNA Our data show the presence only of NHE-1 but not NHE-2 in bovine PMNs.	Amiloride	63-72	sodium/hydrogen exchanger 1	Bos taurus	51-56
28895869-5	2017	Amiloride or zoniporide inhibited the intracellular alkalization induced by PAF without affecting calcium flux.	Amiloride	0-9	PCNA-associated factor	Bos taurus	76-79
28895869-7	2017	Our work led us to conclude that changes in intracellular pH induced by PAF are regulated by NHE-1 in bovine neutrophils, but the effects of amiloride on ROS production and MMP-9 release induced by PAF are not NHE-1 dependent.	Amiloride	141-150	PCNA-associated factor	Bos taurus	198-201
28713285-4	2017	To this end, we fed female mice either a WD or control diet and treated them with or without a very-low-dose of the ENaC-inhibitor amiloride (1 mg/kg/day) in the drinking water for 20 weeks beginning at 4 weeks of age.	Amiloride	131-140	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	116-120
28790369-9	2017	Altogether, AR increased responses of amiloride-sensitive cells required ENaCalpha and ENaCdelta.	Amiloride	38-47	sodium channel epithelial 1 subunit alpha	Homo sapiens	73-82
28790369-9	2017	Altogether, AR increased responses of amiloride-sensitive cells required ENaCalpha and ENaCdelta.	Amiloride	38-47	sodium channel epithelial 1 subunit delta	Homo sapiens	87-96
27865862-8	2017	Treatment with the epithelial Na+ channel blocker amiloride, improving airway surface hydration and mucus clearance, reduced allergen-induced inflammation in Scnn1b-Tg mice.	Amiloride	50-59	sodium channel, nonvoltage-gated 1 beta	Mus musculus	158-164
28526336-9	2017	Amiloride, an inhibitor of Na+/H+ exchanger (NHE), substantially protected both CNE-2 cells and erythrocytes from NV.	Amiloride	0-9	solute carrier family 9 member C1	Homo sapiens	27-43
28526336-9	2017	Amiloride, an inhibitor of Na+/H+ exchanger (NHE), substantially protected both CNE-2 cells and erythrocytes from NV.	Amiloride	0-9	solute carrier family 9 member C1	Homo sapiens	45-48
28430823-4	2017	Amiloride, a splicing regulator in cancer cells, could reverse aberrant histone modification patterns and disrupt the association of splicing complex with GLA.	Amiloride	0-9	galactosidase alpha	Homo sapiens	155-158
28604611-7	2017	Gene expression analyses of laser-captured specimens in ASDN suggested the presence of non-aldosterone-dependent activation of ENaC transcription in ASDN of Nedd4-2 C2 KO mice, which was abolished by amiloride treatment.	Amiloride	200-209	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	127-131
28604611-7	2017	Gene expression analyses of laser-captured specimens in ASDN suggested the presence of non-aldosterone-dependent activation of ENaC transcription in ASDN of Nedd4-2 C2 KO mice, which was abolished by amiloride treatment.	Amiloride	200-209	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	157-164
28430823-6	2017	Our findings revealed the alternative splicing mechanism of GLA (IVS4+919G&gt;A), and a potential treatment for this specific genetic type of Fabry disease by amiloride in the future.	Amiloride	159-168	galactosidase alpha	Homo sapiens	60-63
28082350-9	2017	In summary, the SCT/SCTR axis is involved in aldosterone precursor uptake, and the knockout of SCTR results in defective aldosterone biosynthesis/release and altered sensitivity of ENaCs to amiloride.-Bai, J., Chow, B. K. C. Secretin is involved in sodium conservation through the renin-angiotensin-aldosterone system.	Amiloride	190-199	secretin receptor	Mus musculus	20-24
28365586-5	2017	Patch-clamp experiments detected amiloride-sensitive Na+ currents and TPNQ-sensitive K+ currents in DCT2/CNT, suggesting the activity of ENaC and ROMK.	Amiloride	33-42	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	137-141
28557567-2	2017	We recently reported that NaC contributes to amiloride-insensitive sodium transport in mouse lungs (Respiratory Physiology &amp; Neurobiology, 2016).	Amiloride	45-54	NLR family, pyrin domain containing 1A	Mus musculus	26-29
28082350-9	2017	In summary, the SCT/SCTR axis is involved in aldosterone precursor uptake, and the knockout of SCTR results in defective aldosterone biosynthesis/release and altered sensitivity of ENaCs to amiloride.-Bai, J., Chow, B. K. C. Secretin is involved in sodium conservation through the renin-angiotensin-aldosterone system.	Amiloride	190-199	secretin receptor	Mus musculus	95-99
27941075-7	2017	In oocytes coexpressing deltabetagamma-ENaC and CFTR the ENaC-mediated amiloride-sensitive whole cell current (DeltaIami) was reduced by ~50% compared with that measured in oocytes expressing deltabetagamma-ENaC alone.	Amiloride	71-80	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	39-43
28087701-4	2017	This higher Isc was partially reduced by the addition of apical amiloride and strongly reduced by basolateral bumetanide as well as by depletion of basolateral Cl-, suggesting that Na+/K+/2Cl- (NKCC1/SLC12A2) co-transporter and ENaC are targets of Nedd4L in the colon.	Amiloride	64-73	solute carrier family 12, member 2	Mus musculus	194-199
27122543-7	2017	Chronic intramedullary infusion of an ENaC inhibitor amiloride in rats significantly attenuated ANG II-induced hypertension.	Amiloride	53-62	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	38-42
27941075-7	2017	In oocytes coexpressing deltabetagamma-ENaC and CFTR the ENaC-mediated amiloride-sensitive whole cell current (DeltaIami) was reduced by ~50% compared with that measured in oocytes expressing deltabetagamma-ENaC alone.	Amiloride	71-80	CF transmembrane conductance regulator	Homo sapiens	48-52
27122543-7	2017	Chronic intramedullary infusion of an ENaC inhibitor amiloride in rats significantly attenuated ANG II-induced hypertension.	Amiloride	53-62	angiotensinogen	Rattus norvegicus	96-102
27941075-7	2017	In oocytes coexpressing deltabetagamma-ENaC and CFTR the ENaC-mediated amiloride-sensitive whole cell current (DeltaIami) was reduced by ~50% compared with that measured in oocytes expressing deltabetagamma-ENaC alone.	Amiloride	71-80	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	57-61
27941075-7	2017	In oocytes coexpressing deltabetagamma-ENaC and CFTR the ENaC-mediated amiloride-sensitive whole cell current (DeltaIami) was reduced by ~50% compared with that measured in oocytes expressing deltabetagamma-ENaC alone.	Amiloride	71-80	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	57-61
29214230-6	2017	Amiloride (500 muM), ethanol (up to 0.1% v/v), and DMSO (up to 0.1% v/v) did not reduce cell viability nor induce cytotoxicity.	Amiloride	0-9	latexin	Homo sapiens	15-18
27413200-6	2017	The activity of ENaC measured as whole cell amiloride-sensitive current (INa) in principal cells of the cortical collecting duct (CCD) was minimal under control conditions but was increased by a high-K diet to a similar extent in knockout and wild-type animals.	Amiloride	44-53	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	16-20
27770439-10	2016	Like CQ, other compounds such as amiloride, 2-guanidine-4-methylquinazoline and neuropeptide FF, which have been previously reported to be non-proton ligands that activate ASIC3, undoubtedly evoked the scratching response.	Amiloride	33-42	acid sensing ion channel subunit 3	Rattus norvegicus	172-177
28862523-5	2017	Both nimodipine and amiloride significantly blocked augmentation of intracellular calcium levels and activity of calpains, as well as decreased neurite length, number of differentiated cells, and lowered concentrations of growth-associated protein 43 (GAP-43) and synapsin induced by mipafox.	Amiloride	20-29	growth associated protein 43	Homo sapiens	222-250
28862523-5	2017	Both nimodipine and amiloride significantly blocked augmentation of intracellular calcium levels and activity of calpains, as well as decreased neurite length, number of differentiated cells, and lowered concentrations of growth-associated protein 43 (GAP-43) and synapsin induced by mipafox.	Amiloride	20-29	growth associated protein 43	Homo sapiens	252-258
27820820-2	2016	Accordingly, amiloride, a non-selective inhibitor of ASIC, was protective in an acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson disease.	Amiloride	13-22	acid-sensing (proton-gated) ion channel 1	Mus musculus	53-57
27358052-9	2016	Inhibition of HCO3 (-) absorption by HMGB1 was eliminated by bath amiloride, 0 Na(+) bath, and the F-actin stabilizer jasplakinolide, three conditions that selectively prevent inhibition of MTAL HCO3 (-) absorption mediated through NHE1.	Amiloride	66-75	high mobility group box 1	Rattus norvegicus	37-42
27530514-7	2016	However, when highest dose of RSZ animals were treated with amiloride (ENaC inhibitor) at 2mg/kg the reversal of the adverse effects was evident, indicating the combination of RSZ and amiloride is beneficial in diabetic cardiopathy model.	Amiloride	60-69	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	71-75
27530514-7	2016	However, when highest dose of RSZ animals were treated with amiloride (ENaC inhibitor) at 2mg/kg the reversal of the adverse effects was evident, indicating the combination of RSZ and amiloride is beneficial in diabetic cardiopathy model.	Amiloride	184-193	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	71-75
27259686-8	2016	We conclude that Nac expressed in PMVECs and AEC II contributes to the reabsorption of sodium via an amiloride-insensitive pathway during alveolar fluid clearance.	Amiloride	101-110	NLR family, pyrin domain containing 1A	Mus musculus	17-20
27578589-3	2016	The osteoclasts were exposed to different concentrations of the ENaC inhibitor amiloride, and the expression of ENaC on osteoclasts was examined using immunofluorescence technique.	Amiloride	79-88	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	64-68
27578589-6	2016	RESULTS: s Exposure to different concentrations of amiloride significantly inhibited the expression of ENaC and reduced the number of TRAP-positive osteoclasts.	Amiloride	51-60	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	103-107
27578589-7	2016	Exposure of the osteoclasts to amiloride also reduced the number of bone resorption pits on bone slices and the expression of osteoclast-specific gene cathepsin K.	Amiloride	31-40	cathepsin K	Rattus norvegicus	151-162
27094771-4	2016	Inhibition of urokinase by amiloride abated the effects of TNF-alpha on BBB integrity and MMP-2 activity without affecting that of total PKC.	Amiloride	27-36	tumor necrosis factor	Homo sapiens	59-68
27214087-10	2016	Urine total plasminogen and active plasmin were reduced after amiloride in diabetic nephropathy.	Amiloride	62-71	plasminogen	Homo sapiens	12-19
27214087-11	2016	CONCLUSION: Amiloride increased renal Na excretion, reduced blood pressure, albuminuria, and total and active plasmin in urine.	Amiloride	12-21	plasminogen	Homo sapiens	110-117
26835548-6	2016	NHE activity was estimated in terms of amiloride-sensitive H+-efflux from acid-loaded cells.	Amiloride	39-48	solute carrier family 9 member C1	Homo sapiens	0-3
27094771-4	2016	Inhibition of urokinase by amiloride abated the effects of TNF-alpha on BBB integrity and MMP-2 activity without affecting that of total PKC.	Amiloride	27-36	matrix metallopeptidase 2	Homo sapiens	90-95
27045669-6	2016	Instead, amiloride inhibition was noticeably diminished in the presence of Cd2+ on the apical membrane.	Amiloride	9-18	Cd2 molecule	Rattus norvegicus	75-78
26890278-7	2016	In addition, amiloride and its analogs inhibit ASIC currents in cortical neurons with the same potency rank order.	Amiloride	13-22	acid-sensing (proton-gated) ion channel 1	Mus musculus	47-51
26574046-5	2016	Treatment of lithium-NDI mice with acetazolamide or thiazide/amiloride induced similar antidiuresis and increased urine osmolality and aquaporin-2 abundance.	Amiloride	61-70	aquaporin 2	Mus musculus	135-146
27342076-6	2016	Fast drops of extracellular pH activated transient inward currents which were blocked, in a dose dependent manner, by amiloride, a non-selective ASIC blocker, and by Psalmotoxin-1 (PcTX1), a specific inhibitor for homomeric ASIC1a and heteromeric ASIC1a/2b channels.	Amiloride	118-127	acid sensing ion channel subunit 1	Homo sapiens	145-149
27342076-6	2016	Fast drops of extracellular pH activated transient inward currents which were blocked, in a dose dependent manner, by amiloride, a non-selective ASIC blocker, and by Psalmotoxin-1 (PcTX1), a specific inhibitor for homomeric ASIC1a and heteromeric ASIC1a/2b channels.	Amiloride	118-127	acid-sensing (proton-gated) ion channel 1	Mus musculus	224-230
27342076-6	2016	Fast drops of extracellular pH activated transient inward currents which were blocked, in a dose dependent manner, by amiloride, a non-selective ASIC blocker, and by Psalmotoxin-1 (PcTX1), a specific inhibitor for homomeric ASIC1a and heteromeric ASIC1a/2b channels.	Amiloride	118-127	acid-sensing (proton-gated) ion channel 1	Mus musculus	247-253
26911843-10	2016	Cells overexpressing miR-466g demonstrated 12.9-fold lower level of SGK1 mRNA compared with control cells after 6 h of aldosterone induction; moreover, cells overexpressing miR-466g exhibited 25% decrease in amiloride-sensitive current after 6 h of aldosterone induction and complete loss of amiloride-sensitive current after 24 h of aldosterone induction.	Amiloride	208-217	microRNA 466g	Mus musculus	21-29
26911843-10	2016	Cells overexpressing miR-466g demonstrated 12.9-fold lower level of SGK1 mRNA compared with control cells after 6 h of aldosterone induction; moreover, cells overexpressing miR-466g exhibited 25% decrease in amiloride-sensitive current after 6 h of aldosterone induction and complete loss of amiloride-sensitive current after 24 h of aldosterone induction.	Amiloride	208-217	microRNA 466g	Mus musculus	173-181
26911843-10	2016	Cells overexpressing miR-466g demonstrated 12.9-fold lower level of SGK1 mRNA compared with control cells after 6 h of aldosterone induction; moreover, cells overexpressing miR-466g exhibited 25% decrease in amiloride-sensitive current after 6 h of aldosterone induction and complete loss of amiloride-sensitive current after 24 h of aldosterone induction.	Amiloride	292-301	microRNA 466g	Mus musculus	21-29
26911843-10	2016	Cells overexpressing miR-466g demonstrated 12.9-fold lower level of SGK1 mRNA compared with control cells after 6 h of aldosterone induction; moreover, cells overexpressing miR-466g exhibited 25% decrease in amiloride-sensitive current after 6 h of aldosterone induction and complete loss of amiloride-sensitive current after 24 h of aldosterone induction.	Amiloride	292-301	microRNA 466g	Mus musculus	173-181
26890278-0	2016	Amiloride Analogs as ASIC1a Inhibitors.	Amiloride	0-9	acid-sensing (proton-gated) ion channel 1	Mus musculus	21-27
26890278-3	2016	AIMS: We examined the inhibitory effects of a number of amiloride analogs on ASIC1a currents, aimed at understanding the structure-activity relationship and identifying potent ASIC1a inhibitors for stroke intervention.	Amiloride	56-65	acid-sensing (proton-gated) ion channel 1	Mus musculus	77-83
26890278-12	2016	Among the tested amiloride analogs, benzamil is the most potent ASIC1a inhibitor.	Amiloride	17-26	acid-sensing (proton-gated) ion channel 1	Mus musculus	64-70
27170740-6	2016	Whole-cell patch-clamp recordings were used to measure amiloride-sensitive ENaC currents in nephron fragments from mice maintained on different sodium diets to vary plasma aldosterone levels.	Amiloride	55-64	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	75-79
27173673-6	2016	With stronger acid signals sustained currents are maintained in the absence of extracellular Na(+) or the presence of the ASIC blockers amiloride and Psalmotoxin-1(PcTx1).	Amiloride	136-145	acid-sensing (proton-gated) ion channel 1	Mus musculus	122-126
27006319-16	2016	A 40% decrease in Rock1 expression also was observed after long-term treatment with hydrochlorothiazide plus amiloride.	Amiloride	109-118	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	18-23
27058411-9	2016	RESULTS: SOCS-1 overexpression sufficiently restored transepithelial current and resistance in MLE-12 cells treated with either IL-1beta or amiloride.	Amiloride	140-149	suppressor of cytokine signaling 1	Mus musculus	9-15
27009163-4	2016	IL-1beta elicited an amiloride-sensitive increase in Na(+) transport in taste buds.	Amiloride	21-30	interleukin 1 beta	Homo sapiens	0-8
27009163-5	2016	In contrast, TNF-alpha dramatically and reversibly decreased Na(+) flux in polarized taste buds via amiloride-sensitive and amiloride-insensitive Na(+) transport systems.	Amiloride	100-109	tumor necrosis factor	Homo sapiens	13-22
27009163-5	2016	In contrast, TNF-alpha dramatically and reversibly decreased Na(+) flux in polarized taste buds via amiloride-sensitive and amiloride-insensitive Na(+) transport systems.	Amiloride	124-133	tumor necrosis factor	Homo sapiens	13-22
27009163-6	2016	The speed and partial amiloride sensitivity of these changes in Na(+) flux indicate that IL-1beta and TNF-alpha modulate epithelial Na(+) channel (ENaC) function.	Amiloride	22-31	interleukin 1 beta	Homo sapiens	89-97
27009163-6	2016	The speed and partial amiloride sensitivity of these changes in Na(+) flux indicate that IL-1beta and TNF-alpha modulate epithelial Na(+) channel (ENaC) function.	Amiloride	22-31	tumor necrosis factor	Homo sapiens	102-111
27009163-7	2016	A portion of the TNF-mediated decrease in Na(+) flux is also blocked by the TRPV1 antagonist capsazepine, although TNF-alpha further reduced Na(+) transport independently of both amiloride and capsazepine.	Amiloride	179-188	tumor necrosis factor	Homo sapiens	17-20
26963391-11	2016	Western blot analysis demonstrated significant enhancement in ENaC expression in medulla and cortex of NCC KO and WT mice in response to ACTZ injection for 6 days, and treatment with amiloride in ACTZ-pretreated mice caused a robust increase in salt excretion in both NCC KO and WT mice.	Amiloride	183-192	solute carrier family 12, member 3	Mus musculus	268-271
26724207-0	2016	Probing interactions of Vpu from HIV-1 with amiloride-based compounds.	Amiloride	44-53	Vpu	Human immunodeficiency virus 1	24-27
26724207-4	2016	In this study, we investigate the binding properties of amiloride compounds to Vpu embedded into liposomes using surface plasmon resonance (SPR).	Amiloride	56-65	Vpu	Human immunodeficiency virus 1	79-82
26724207-8	2016	These findings indicate that small molecules such as amilorides are capable of specifically interacting with Vpu ion channels.	Amiloride	53-63	Vpu	Human immunodeficiency virus 1	109-112
26988221-4	2016	Inhibition of E-selectin expression on the surface of endothelial cells was obtained by using cimetidine and amiloride treatment.	Amiloride	109-118	selectin E	Homo sapiens	14-24
26988221-5	2016	RESULTS: Cimetidine and amiloride inhibited, respectively, by 20 and 64 % E-selectin expression by activated endothelial cells and significantly subsequent adhesion of HepG2 cells to activated endothelial cells.	Amiloride	24-33	selectin E	Homo sapiens	74-84
26938814-7	2016	RESULTS: The difference in SBP during 18 months of follow-up was 2.3 (95% confidence interval: 1.2 to 3.3) mmHg favoring chlorthalidone/amiloride.	Amiloride	136-145	selenium binding protein 1	Homo sapiens	27-30
26963391-7	2016	RESULTS: Amiloride injection significantly increased the urine output (UO) in NCC KO mice (from 1.3 ml/day before to 2.5 ml/day after amiloride, p&lt;0.03, n = 4) but caused only a slight change in UO in WT mice (p&gt;0.05).	Amiloride	9-18	solute carrier family 12, member 3	Mus musculus	78-81
26963391-8	2016	The increase in UO in NCC KO mice was associated with a significant increase in sodium excretion (from 0.25 mmol/24 hrs at baseline to 0.35 mmol/24 hrs after amiloride injection, p&lt;0.05, n = 4).	Amiloride	158-167	solute carrier family 12, member 3	Mus musculus	22-25
26963391-11	2016	Western blot analysis demonstrated significant enhancement in ENaC expression in medulla and cortex of NCC KO and WT mice in response to ACTZ injection for 6 days, and treatment with amiloride in ACTZ-pretreated mice caused a robust increase in salt excretion in both NCC KO and WT mice.	Amiloride	183-192	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	62-66
26956209-4	2016	Treatment of ASCs with the amiloride derivative phenamil, a positive regulator of BMP signaling, combined with gene manipulation to suppress the BMP antagonist noggin, significantly enhanced osteogenic differentiation of ASCs through increased BMP-Smad signaling in vitro.	Amiloride	27-36	noggin	Mus musculus	160-166
26963391-18	2016	ENaC is upregulated by ACTZ treatment and its inhibition by amiloride causes significant diuresis in NCC KO and WT mice.	Amiloride	60-69	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	0-4
26963391-11	2016	Western blot analysis demonstrated significant enhancement in ENaC expression in medulla and cortex of NCC KO and WT mice in response to ACTZ injection for 6 days, and treatment with amiloride in ACTZ-pretreated mice caused a robust increase in salt excretion in both NCC KO and WT mice.	Amiloride	183-192	solute carrier family 12, member 3	Mus musculus	103-106
26963391-18	2016	ENaC is upregulated by ACTZ treatment and its inhibition by amiloride causes significant diuresis in NCC KO and WT mice.	Amiloride	60-69	solute carrier family 12, member 3	Mus musculus	101-104
26963391-19	2016	Despite being considered mild agents individually, we propose that the combination of acetazolamide and amiloride in the setting of NCC inhibition (i.e., hydrochlorothiazide) will be a powerful diuretic regimen.	Amiloride	104-113	solute carrier family 12, member 3	Mus musculus	132-135
27606670-8	2016	LEFTYA increased amiloride sensitive Na+-currents in Ishikawa cells and amiloride sensitive transepithelial current across the murine endometrium.	Amiloride	17-26	left-right determination factor 2	Homo sapiens	0-6
26743432-6	2016	However, amiloride or sodium orthovanadate could significantly elevate K(+) effluxes and decrease Na(+) efflux and H(+) influx in salt-treated transgenic roots, but the K(+) effluxes were inhibited by TEA, suggesting that ion fluxes regulated by AtLOS5 overexpression were possibly due to activation of Na(+)/H(+) antiport and K(+) channels across the plasma membrane.	Amiloride	9-18	molybdenum cofactor sulfurase (LOS5) (ABA3)	Arabidopsis thaliana	246-252
26695697-9	2016	The potential advantage of the use of amiloride and amiloride-derivatives for cancer treatment in terms of NHE1 expression and activity is also discussed as a therapeutic approach in human ovarian cancer.	Amiloride	38-47	solute carrier family 9 member A1	Homo sapiens	107-111
26807262-11	2016	LEARNING POINTS: PHA1 is a rare genetic condition, causing functional abnormalities of the amiloride-sensitive ENaC.PHA1 was caused by previously unreported SCNN1B gene mutations (c.1288delC and c.1466+1 G&gt;A).Early recognition of this condition and adherence to symptomatic therapy is important, as the electrolyte abnormalities found may lead to severe dehydration, cardiac arrhythmias and even death.High doses of sodium polystyrene sulfonate, sodium chloride and sodium bicarbonate are required for symptomatic treatment.	Amiloride	91-100	sodium channel epithelial 1 subunit gamma	Homo sapiens	17-21
26807262-11	2016	LEARNING POINTS: PHA1 is a rare genetic condition, causing functional abnormalities of the amiloride-sensitive ENaC.PHA1 was caused by previously unreported SCNN1B gene mutations (c.1288delC and c.1466+1 G&gt;A).Early recognition of this condition and adherence to symptomatic therapy is important, as the electrolyte abnormalities found may lead to severe dehydration, cardiac arrhythmias and even death.High doses of sodium polystyrene sulfonate, sodium chloride and sodium bicarbonate are required for symptomatic treatment.	Amiloride	91-100	sodium channel epithelial 1 subunit gamma	Homo sapiens	116-120
26807262-11	2016	LEARNING POINTS: PHA1 is a rare genetic condition, causing functional abnormalities of the amiloride-sensitive ENaC.PHA1 was caused by previously unreported SCNN1B gene mutations (c.1288delC and c.1466+1 G&gt;A).Early recognition of this condition and adherence to symptomatic therapy is important, as the electrolyte abnormalities found may lead to severe dehydration, cardiac arrhythmias and even death.High doses of sodium polystyrene sulfonate, sodium chloride and sodium bicarbonate are required for symptomatic treatment.	Amiloride	91-100	sodium channel epithelial 1 subunit beta	Homo sapiens	157-163
26695697-9	2016	The potential advantage of the use of amiloride and amiloride-derivatives for cancer treatment in terms of NHE1 expression and activity is also discussed as a therapeutic approach in human ovarian cancer.	Amiloride	52-61	solute carrier family 9 member A1	Homo sapiens	107-111
26823770-10	2015	Compared with SE groups, the expression of ASIC1a and ASIC3 mRNA in amiloride group decreased significantly.	Amiloride	68-77	acid sensing ion channel subunit 3	Rattus norvegicus	54-59
26733809-4	2015	These ASIC currents are primarily carried by Na(+), exhibit fast activation and desensitization, display a pH50 of 6.2 and are blocked by amiloride, indicating that these are ASIC currents.	Amiloride	138-147	acid sensing ion channel subunit 1	Homo sapiens	6-10
26733809-4	2015	These ASIC currents are primarily carried by Na(+), exhibit fast activation and desensitization, display a pH50 of 6.2 and are blocked by amiloride, indicating that these are ASIC currents.	Amiloride	138-147	acid sensing ion channel subunit 1	Homo sapiens	175-179
26522226-9	2015	RESULTS: Injection of cRNA encoding ENaC into Xenopus oocytes was followed by appearance of amiloride sensitive current, which was significantly enhanced by additional injection of cRNA encoding VP1, but not by additional injection of cRNA encoding PLA2-negative VP1 mutant (H153A).	Amiloride	92-101	capsid protein 1	Human parvovirus B19	195-198
26823770-12	2015	CONCLUSION: Amiloride inhibited pilocarpine-induced SE and the anti-epileptic mechanism was associated with deactivation of the ASIC1a and ASIC3 instead of NHE in rats.	Amiloride	12-21	acid sensing ion channel subunit 3	Rattus norvegicus	139-144
26294672-8	2015	This effect was significantly reduced after pretreatment with 5-iodoresiniferatoxin (IRTX), a TRPV1-specific antagonist, or with amiloride, a nonselective ASIC blocker.	Amiloride	129-138	acid sensing ion channel subunit 1	Homo sapiens	155-159
26180239-11	2015	Bath amiloride, which selectively prevents inhibition of MTAL HCO(3)(-) absorption mediated through Na+/H+ exchanger 1 (NHE1), eliminated inhibition by HMGB1.	Amiloride	5-14	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	100-118
26180239-11	2015	Bath amiloride, which selectively prevents inhibition of MTAL HCO(3)(-) absorption mediated through Na+/H+ exchanger 1 (NHE1), eliminated inhibition by HMGB1.	Amiloride	5-14	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	120-124
26180239-11	2015	Bath amiloride, which selectively prevents inhibition of MTAL HCO(3)(-) absorption mediated through Na+/H+ exchanger 1 (NHE1), eliminated inhibition by HMGB1.	Amiloride	5-14	high mobility group box 1	Mus musculus	152-157
26357686-2	2015	Intrathecal alpha2-adrenergic receptor agonists produce pronounced analgesia, and amiloride modulates alpha2-adrenergic receptor agonist binding and function, acting via the allosteric site on the alpha2A-adrenergic receptor.	Amiloride	82-91	adrenoceptor alpha 2A	Rattus norvegicus	197-224
26357686-12	2015	Intrathecally administered amiloride synergistically interacts with tizanidine to reduce the nociceptive response in the formalin test, most likely by activating alpha2-adrenoceptors in the spinal cord.	Amiloride	27-36	adrenoceptor alpha 2A	Rattus norvegicus	162-182
26112825-3	2015	Estimated IC50 for inhibition of NHE activity by amiloride and EIPA were 55 mumol l(-1) and 4.8 mumol l(-1), respectively, for NHE2 and 9 mumol l(-1) and 24 mumol l(-1), respectively, for NHE3.	Amiloride	49-58	solute carrier family 9 member A2	Homo sapiens	127-131
26112825-3	2015	Estimated IC50 for inhibition of NHE activity by amiloride and EIPA were 55 mumol l(-1) and 4.8 mumol l(-1), respectively, for NHE2 and 9 mumol l(-1) and 24 mumol l(-1), respectively, for NHE3.	Amiloride	49-58	solute carrier family 9 member A3	Homo sapiens	188-192
26112825-5	2015	Although the IC50 are similar for the two isoforms, dfNHE2 is less sensitive than human NHE2 to inhibition by amiloride and EIPA, while dfNHE3 is more sensitive than human NHE3.	Amiloride	110-119	solute carrier family 9 member A2	Homo sapiens	54-58
25864651-0	2015	Amiloride sensitizes human pancreatic cancer cells to erlotinib in vitro through inhibition of the PI3K/AKT signaling pathway.	Amiloride	0-9	AKT serine/threonine kinase 1	Homo sapiens	104-107
26108662-2	2015	Glioma cells express an amiloride-sensitive nonselective cation channel composed of acid-sensing ion channel (ASIC)-1 and epithelial Na(+) channel (ENaC) alpha- and gamma-subunits.	Amiloride	24-33	acid sensing ion channel subunit 1	Homo sapiens	84-117
26108662-5	2015	Short hairpin RNA knockdown of integrin-beta1 attenuated the amiloride-sensitive current, which was due to loss of surface expression of ASIC-1.	Amiloride	61-70	integrin subunit beta 1	Homo sapiens	31-45
26108662-5	2015	Short hairpin RNA knockdown of integrin-beta1 attenuated the amiloride-sensitive current, which was due to loss of surface expression of ASIC-1.	Amiloride	61-70	acid sensing ion channel subunit 1	Homo sapiens	137-143
26108662-8	2015	Downregulation of alpha-actinin-1 or -4 attenuated the amiloride-sensitive current.	Amiloride	55-64	actinin alpha 1	Homo sapiens	18-39
26108662-9	2015	Mutation of the putative binding site for alpha-actinin on the COOH terminus of ASIC-1 reduced the membrane localization of ASIC-1 and also resulted in attenuation of the amiloride-sensitive current.	Amiloride	171-180	actinin alpha 1	Homo sapiens	42-55
26108662-9	2015	Mutation of the putative binding site for alpha-actinin on the COOH terminus of ASIC-1 reduced the membrane localization of ASIC-1 and also resulted in attenuation of the amiloride-sensitive current.	Amiloride	171-180	acid sensing ion channel subunit 1	Homo sapiens	80-86
26108662-10	2015	Our data suggest a novel interaction between the amiloride-sensitive glioma cation channel and integrin-beta1, mediated by alpha-actinin.	Amiloride	49-58	integrin subunit beta 1	Homo sapiens	95-109
26108662-10	2015	Our data suggest a novel interaction between the amiloride-sensitive glioma cation channel and integrin-beta1, mediated by alpha-actinin.	Amiloride	49-58	actinin alpha 1	Homo sapiens	123-136
26309024-6	2015	In consequence, ENaC activity, as monitored by the amiloride-sensitive rectal potential difference (DeltaPD), was not altered even under dietary sodium restriction.	Amiloride	51-60	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	16-20
26167467-12	2015	After hypertonic saline, u-NKCC2 increased during amiloride (6% +- 34%; P = 0.081) and increased significantly during placebo (17% +- 24%; P = 0.010).	Amiloride	50-59	solute carrier family 12 member 1	Homo sapiens	27-32
26167467-13	2015	U-AQP2 increased significantly during amiloride (31% +- 22%; P &lt; 0.001) and placebo (34% +- 27%; P &lt; 0.001), while u-NKCC2 and u-AQP2 did not change significantly during BFTZ (-7% +- 28%; P = 0.257 and 5% +- 16%; P = 0.261).	Amiloride	38-47	aquaporin 2	Homo sapiens	2-6
26167467-18	2015	CONCLUSION: After hypertonic saline, u-NKCC2 and u-AQP2 increased during amiloride, but not during BFTZ.	Amiloride	73-82	solute carrier family 12 member 1	Homo sapiens	39-44
26167467-18	2015	CONCLUSION: After hypertonic saline, u-NKCC2 and u-AQP2 increased during amiloride, but not during BFTZ.	Amiloride	73-82	aquaporin 2	Homo sapiens	51-55
25941340-4	2015	In untreated mice, the mean arterial pressure was higher in knockout, compared with wild-type (WT); however, treatment with amiloride, a blocker of ENaC, abolished this difference.	Amiloride	124-133	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	148-152
25941340-10	2015	The reduced Vte in knockout was amiloride sensitive and therefore revealed an upregulation of electrogenic ENaC-mediated Na(+) reabsorption in this segment.	Amiloride	32-41	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	107-111
25612314-0	2015	Inhibition of RANKL-dependent cellular fusion in pre-osteoclasts by amiloride and a NHE10-specific monoclonal antibody.	Amiloride	68-77	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	14-19
26225927-1	2015	The aim of this study was to investigate the antinociception of intrathecal amiloride and examine its effect on the neuropathic pain-induced activation of c-Fos and p-p38 MAPK in the rat spinal dorsal horn (SDH).	Amiloride	76-85	mitogen activated protein kinase 14	Rattus norvegicus	167-170
26225927-3	2015	Immunohistochemical techniques were utilized to detect the expression of c-Fos and p-p38 in SDH in the control and amiloride (100mug) groups.	Amiloride	115-124	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	73-78
26225927-3	2015	Immunohistochemical techniques were utilized to detect the expression of c-Fos and p-p38 in SDH in the control and amiloride (100mug) groups.	Amiloride	115-124	mitogen activated protein kinase 14	Rattus norvegicus	85-88
26225927-5	2015	Additionally, immunohistochemical experiments showed that the expression of c-Fos and p-p38 dramatically decreased in the superficial laminae of the ipsilateral SDH in the 100-mug amiloride group (P&lt;0.01), whereas, there was no statistical significance on the contralateral side, compared with the control group.	Amiloride	180-189	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	76-81
26225927-5	2015	Additionally, immunohistochemical experiments showed that the expression of c-Fos and p-p38 dramatically decreased in the superficial laminae of the ipsilateral SDH in the 100-mug amiloride group (P&lt;0.01), whereas, there was no statistical significance on the contralateral side, compared with the control group.	Amiloride	180-189	mitogen activated protein kinase 14	Rattus norvegicus	88-91
26345885-0	2015	Amiloride, a urokinase-type plasminogen activator receptor (uTPA) inhibitor, reduces proteinurea in podocytes.	Amiloride	0-9	plasminogen activator, urokinase receptor	Homo sapiens	13-58
26345885-1	2015	This study examined the mechanism of action of amiloride, a urokinase-type plasminogen activator receptor inhibitor, in lowering proteinuria.	Amiloride	47-56	plasminogen activator, urokinase receptor	Homo sapiens	60-105
26345885-6	2015	The protein expression rate of uPAR in the lipopolysaccharide group was significantly higher than those in the control and lipopolysaccharide + amiloride groups (P &lt; 0.05).	Amiloride	144-153	plasminogen activator, urokinase receptor	Homo sapiens	31-35
26345885-9	2015	uPAR expression was significantly downregulated, and the fusion of the podocyte-specific skelemin synaptopodin on the glomerulus podocytes was significantly decreased in the lipopolysaccharide + amiloride group.	Amiloride	195-204	plasminogen activator, urokinase receptor	Homo sapiens	0-4
26345885-9	2015	uPAR expression was significantly downregulated, and the fusion of the podocyte-specific skelemin synaptopodin on the glomerulus podocytes was significantly decreased in the lipopolysaccharide + amiloride group.	Amiloride	195-204	myomesin 1	Homo sapiens	89-97
26345885-10	2015	These results suggest that amiloride is able to reduce cell motility and thus lower proteinuria by inhibiting the expression of uPAR in podocytes.	Amiloride	27-36	plasminogen activator, urokinase receptor	Homo sapiens	128-132
25972510-0	2015	Aberrant glomerular filtration of urokinase-type plasminogen activator in nephrotic syndrome leads to amiloride-sensitive plasminogen activation in urine.	Amiloride	102-111	plasminogen activator, urokinase	Homo sapiens	34-70
25972510-2	2015	The ENaC blocker amiloride is an off-target inhibitor of urokinase-type plasminogen activator (uPA) in vitro.	Amiloride	17-26	plasminogen activator, urokinase	Homo sapiens	57-93
25972510-2	2015	The ENaC blocker amiloride is an off-target inhibitor of urokinase-type plasminogen activator (uPA) in vitro.	Amiloride	17-26	plasminogen activator, urokinase	Homo sapiens	95-98
25972510-3	2015	It was hypothesized that uPA is abnormally filtered to preurine and is inhibited in urine by amiloride in nephrotic syndrome.	Amiloride	93-102	plasminogen activator, urokinase	Homo sapiens	25-28
25972510-7	2015	Amiloride (2 mg kg(-1) 24 h(-1)) concentration in urine was in the range 10-20 mumol/l and reduced significantly urine uPA activity, plasminogen activation, protease activity, and sodium retention in PAN rats, while proteinuria was not altered.	Amiloride	0-9	plasminogen activator, urokinase	Rattus norvegicus	119-122
25972510-11	2015	Amiloride inhibits urine uPA activity which attenuates plasminogen activation and urine protease activity in vivo.	Amiloride	0-9	plasminogen activator, urokinase	Homo sapiens	25-28
25972510-12	2015	Urine uPA is a relevant target for amiloride in vivo.	Amiloride	35-44	plasminogen activator, urokinase	Homo sapiens	6-9
25573195-1	2015	BACKGROUND AND PURPOSE: Inhaled amiloride, a blocker of the epithelial sodium channel (ENaC), enhances mucociliary clearance (MCC) in cystic fibrosis (CF) patients.	Amiloride	32-41	amiloride-sensitive sodium channel subunit alpha	Cavia porcellus	87-91
25573195-2	2015	However, the dose of amiloride is limited by the mechanism-based side effect of hyperkalaemia resulting from renal ENaC blockade.	Amiloride	21-30	amiloride-sensitive sodium channel subunit alpha	Cavia porcellus	115-119
25864651-8	2015	Amiloride inhibited EGF-stimulated phorsphorylation of AKT, and significantly enhanced erlotinib-induced downregulation of phorsphorylation of EGFR, AKT, PI3K P85 and GSK 3beta in Bxpc-3 and PANC-1 cells.	Amiloride	0-9	AKT serine/threonine kinase 1	Homo sapiens	55-58
25864651-8	2015	Amiloride inhibited EGF-stimulated phorsphorylation of AKT, and significantly enhanced erlotinib-induced downregulation of phorsphorylation of EGFR, AKT, PI3K P85 and GSK 3beta in Bxpc-3 and PANC-1 cells.	Amiloride	0-9	epidermal growth factor receptor	Homo sapiens	143-147
25864651-8	2015	Amiloride inhibited EGF-stimulated phorsphorylation of AKT, and significantly enhanced erlotinib-induced downregulation of phorsphorylation of EGFR, AKT, PI3K P85 and GSK 3beta in Bxpc-3 and PANC-1 cells.	Amiloride	0-9	AKT serine/threonine kinase 1	Homo sapiens	149-152
25864651-8	2015	Amiloride inhibited EGF-stimulated phorsphorylation of AKT, and significantly enhanced erlotinib-induced downregulation of phorsphorylation of EGFR, AKT, PI3K P85 and GSK 3beta in Bxpc-3 and PANC-1 cells.	Amiloride	0-9	glycogen synthase kinase 3 beta	Homo sapiens	167-176
25864651-9	2015	CONCLUSION: Amiloride sensitizes human pancreatic cancer cells to erlotinib in vitro through inhibition of the PI3K/AKT signaling pathway.	Amiloride	12-21	AKT serine/threonine kinase 1	Homo sapiens	116-119
25592168-2	2015	The aim of the present study was to examine the effects of amiloride on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis and to elucidate the underlying mechanisms in the RAW264.7 murine macrophage cell line.	Amiloride	59-68	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	72-122
25849763-6	2015	The results of this study clearly demonstrate that amilorides inhibit complex I activity by occupying the quinone binding pocket rather than directly blocking translocation of protons through the antiporter-like subunits (ND2, ND4, and ND5).	Amiloride	51-61	NADH dehydrogenase subunit 2	Bos taurus	222-225
25849763-6	2015	The results of this study clearly demonstrate that amilorides inhibit complex I activity by occupying the quinone binding pocket rather than directly blocking translocation of protons through the antiporter-like subunits (ND2, ND4, and ND5).	Amiloride	51-61	NADH dehydrogenase subunit 4	Bos taurus	227-230
25849763-6	2015	The results of this study clearly demonstrate that amilorides inhibit complex I activity by occupying the quinone binding pocket rather than directly blocking translocation of protons through the antiporter-like subunits (ND2, ND4, and ND5).	Amiloride	51-61	NADH dehydrogenase subunit 5	Bos taurus	236-239
25592168-2	2015	The aim of the present study was to examine the effects of amiloride on receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclastogenesis and to elucidate the underlying mechanisms in the RAW264.7 murine macrophage cell line.	Amiloride	59-68	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	124-129
25592168-6	2015	The results showed that amiloride significantly reduced the number of TRAP-positive multinucleated cells as well as the bone resorption area.	Amiloride	24-33	acid phosphatase 5, tartrate resistant	Mus musculus	70-74
25592168-7	2015	Amiloride also downregulated the expression of NFATc1 mRNA and inhibited the expression of osteoclast-specific genes.	Amiloride	0-9	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	47-53
25592168-8	2015	A possible underlying mechanism may be that amiloride suppresses the degradation of the inhibitor of NF-kappaB and blocks the activation of c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38, thus implicating the NF-kappaB and MAPK pathway is this process.	Amiloride	44-53	mitogen-activated protein kinase 14	Mus musculus	207-210
25012174-7	2015	Eplerenone and amiloride each increased plasma aldosterone by 3-fold and renin concentration slightly but did not significantly change eGFR.	Amiloride	15-24	renin	Homo sapiens	73-78
25587116-3	2015	Basolateral application of several different concentrations of PRL dramatically stimulated the transepithelial current in A6 cells, increasing both amiloride-sensitive (ENaC) and amiloride-insensitive currents.	Amiloride	148-157	prolactin	Homo sapiens	63-66
25587116-3	2015	Basolateral application of several different concentrations of PRL dramatically stimulated the transepithelial current in A6 cells, increasing both amiloride-sensitive (ENaC) and amiloride-insensitive currents.	Amiloride	179-188	prolactin	Homo sapiens	63-66
25587116-5	2015	Inhibition of PKA with H-89 abolished the effect of PRL on amiloride-sensitive and insensitive transepithelial currents and eliminated the increase in ENaC NPo with PRL exposure.	Amiloride	59-68	prolactin	Homo sapiens	52-55
25774517-3	2015	Expression of a constitutively active H-Ras mutant inhibited the amiloride-sensitive current.	Amiloride	65-74	Harvey rat sarcoma virus oncogene	Mus musculus	38-43
25482671-6	2015	Urine from these patients activates, plasmin-dependently, amiloride-sensitive inward current in vitro.	Amiloride	58-67	plasminogen	Homo sapiens	37-44
25482671-7	2015	The concept predicts that patients with albuminuria may benefit particularly from reduced salt intake with RAS blockers; that distally acting diuretics, in particular amiloride, are warranted in low-renin/albuminuric conditions; and that urine serine proteases and their activators may be pharmacological targets.	Amiloride	167-176	renin	Homo sapiens	199-204
25557402-0	2015	Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema.	Amiloride	21-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	39-44
25557402-2	2015	Here, the potent ENaC blocker amiloride was injected intraperitoneally in rats and 2h later, the c-Fos activation pattern in the CVOs was studied.	Amiloride	30-39	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	97-102
25557402-5	2015	The AP projects to FoxP2-expressing neurons in the dorsolateral pons which include the pre-locus coeruleus nucleus and external lateral part of the parabrachial nucleus; both cell groups were c-Fos activated following systemic injections of amiloride.	Amiloride	241-250	forkhead box P2	Rattus norvegicus	19-24
25557402-5	2015	The AP projects to FoxP2-expressing neurons in the dorsolateral pons which include the pre-locus coeruleus nucleus and external lateral part of the parabrachial nucleus; both cell groups were c-Fos activated following systemic injections of amiloride.	Amiloride	241-250	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	192-197
25391901-5	2015	We determined that nitric oxide synthase 1 (NOS1) and NOS3 contribute to shear stress-mediated NO production in the CD, that is attenuated by low doses of the ENaC inhibitors amiloride and benzamil.	Amiloride	175-184	nitric oxide synthase 1, neuronal	Mus musculus	19-42
25391901-5	2015	We determined that nitric oxide synthase 1 (NOS1) and NOS3 contribute to shear stress-mediated NO production in the CD, that is attenuated by low doses of the ENaC inhibitors amiloride and benzamil.	Amiloride	175-184	nitric oxide synthase 1, neuronal	Mus musculus	44-48
25391901-5	2015	We determined that nitric oxide synthase 1 (NOS1) and NOS3 contribute to shear stress-mediated NO production in the CD, that is attenuated by low doses of the ENaC inhibitors amiloride and benzamil.	Amiloride	175-184	nitric oxide synthase 3, endothelial cell	Mus musculus	54-58
25391901-5	2015	We determined that nitric oxide synthase 1 (NOS1) and NOS3 contribute to shear stress-mediated NO production in the CD, that is attenuated by low doses of the ENaC inhibitors amiloride and benzamil.	Amiloride	175-184	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	159-163
25268680-7	2015	Pharmacological analysis showed that the mechanosensitive channels were potently blocked by amiloride (1mM) and Gd3+ (10 muM) in a voltage-dependent manner.	Amiloride	92-101	latexin	Homo sapiens	121-124
25413068-0	2014	[Amiloride reduces proteinuria and inhibits podocyte uPAR in the 5/6 nephrectomy rats].	Amiloride	1-10	plasminogen activator, urokinase receptor	Rattus norvegicus	53-57
26634216-8	2015	HMAP, DPI, and amiloride (a Na(+)/H(+) exchanger inhibitor) inhibited the Akt phosphorylation and did not affect the p38 MAPK and ERK1/2 activity.	Amiloride	15-24	AKT serine/threonine kinase 1	Homo sapiens	74-77
26160150-3	2015	METHODS: ENaC was expressed in Xenopus oocytes with or without additional expression of wild type SPAK, constitutively active (T233E)SPAK, WNK insensitive (T233A)SPAK or catalytically inactive (D212A)SPAK, and ENaC activity estimated from amiloride (50 microM) sensitive current (Iamil) in dual electrode voltage clamp experiments.	Amiloride	239-248	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	9-13
25506946-5	2014	The biophysical properties and the responses to PcTx1, amiloride, Ca2+ and Zn2+ suggested that ASIC currents were mediated predominantly by heteromultimeric channels that contained ASIC1a and ASIC2a or ASIC2b.	Amiloride	55-64	acid-sensing (proton-gated) ion channel 1	Mus musculus	95-99
25301142-8	2014	In the absence of ligands, ICAM-1 also underwent amiloride-sensitive endocytosis with peripheral distribution, suggesting that monomeric (not multimeric) anti-ICAM follows the route of this receptor.	Amiloride	49-58	intercellular adhesion molecule 1	Homo sapiens	27-33
25531136-2	2015	Clinical limitations include TZD-induced fluid retention and body weight (BW) increase, which are inhibited by amiloride, an epithelial-sodium channel (ENaC) blocker.	Amiloride	111-120	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	152-156
25492830-4	2014	Amiloride, an ENaC inhibitor, inhibits urokinase-type plasminogen activator.	Amiloride	0-9	plasminogen activator, urokinase	Homo sapiens	39-75
25492830-5	2014	We hypothesized that amiloride (1) reduces blood pressure (BP); (2) attenuates plasminogen-to-plasmin activation; and (3) inhibits urine urokinase-type plasminogen activator in patients with resistant hypertension and type 2 diabetes mellitus (T2DM).In an open-label, non-randomized, 8-week intervention study, a cohort (n = 80) of patients with resistant hypertension and T2DM were included.	Amiloride	21-30	plasminogen activator, urokinase	Homo sapiens	137-173
25413068-7	2014	In contrast, the expression of uPAR mRNA in NTX rats treated with amiloride was significantly lower than in NTX group (9.74 +- 1.44 vs 5.01 +- 1.36, P = 0.000).	Amiloride	66-75	plasminogen activator, urokinase receptor	Rattus norvegicus	31-35
25413068-8	2014	CONCLUSION: Amiloride can reduce the proteinuria of the 5/6 nephrectomy rats model of transient proteinuria by inhibiting the induction of uPAR expression.	Amiloride	12-21	plasminogen activator, urokinase receptor	Rattus norvegicus	139-143
24905230-5	2014	Amiloride significantly decreased the expression of the pro-apoptotic transcription factor CHOP in the injured spinal cord and significantly increased the expression of the ER chaperone GRP78, which protects cells against ER stress.	Amiloride	0-9	DNA-damage inducible transcript 3	Rattus norvegicus	91-95
25350285-4	2014	The consensus amiloride binding motif (84LFFIYLLPPI93) was observed in the third putative transmembrane domain of VrNHX1.	Amiloride	14-23	sodium/hydrogen exchanger 2-like	Vigna radiata	114-120
24944201-5	2014	In epithelial cells, overexpression of wild-type (wt) ERp29 increased ENaC functional expression [amiloride-sensitive short-circuit current (Isc)] in Ussing chamber experiments, as well as the abundance of the cleaved form of gamma-ENaC in whole cell lysates.	Amiloride	98-107	endoplasmic reticulum protein 29	Homo sapiens	54-59
24944201-7	2014	Cells in which wt ERp29 was overexpressed had a smaller fractional increase in amiloride-sensitive Isc when trypsin was applied to the apical surface to activate uncleaved ENaC, while cells in which C157S ERp29 was overexpressed or ERp29 was depleted had a significantly greater fractional increase in amiloride-sensitive Isc in response to trypsin.	Amiloride	79-88	endoplasmic reticulum protein 29	Homo sapiens	18-23
24944201-7	2014	Cells in which wt ERp29 was overexpressed had a smaller fractional increase in amiloride-sensitive Isc when trypsin was applied to the apical surface to activate uncleaved ENaC, while cells in which C157S ERp29 was overexpressed or ERp29 was depleted had a significantly greater fractional increase in amiloride-sensitive Isc in response to trypsin.	Amiloride	302-311	endoplasmic reticulum protein 29	Homo sapiens	18-23
24905230-5	2014	Amiloride significantly decreased the expression of the pro-apoptotic transcription factor CHOP in the injured spinal cord and significantly increased the expression of the ER chaperone GRP78, which protects cells against ER stress.	Amiloride	0-9	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	186-191
24905230-6	2014	In addition, amiloride treatment led to a significant decrease in ER stress-induced apoptosis and a significant increase of NG2-positive OPCs in the injured spinal cord.	Amiloride	13-22	chondroitin sulfate proteoglycan 4	Rattus norvegicus	124-127
24905230-7	2014	Furthermore, in vitro experiments performed to investigate the direct effect of amiloride on OPCs revealed that amiloride reduced CHOP expression in OPCs cultured under ER stress.	Amiloride	112-121	DNA-damage inducible transcript 3	Rattus norvegicus	130-134
25079679-9	2014	Taken together, our data showed that amiloride, PcTX1, and ibuprofen decreased ASIC protein expression and thereby exerted protective effects from ASIC inhibition-mediated cell damage.	Amiloride	37-46	acid sensing ion channel subunit 1	Homo sapiens	79-83
25079679-9	2014	Taken together, our data showed that amiloride, PcTX1, and ibuprofen decreased ASIC protein expression and thereby exerted protective effects from ASIC inhibition-mediated cell damage.	Amiloride	37-46	acid sensing ion channel subunit 1	Homo sapiens	147-151
25347857-0	2014	Nerve growth factor reduces amiloride-sensitive Na+ transport in human airway epithelial cells.	Amiloride	28-37	nerve growth factor	Homo sapiens	0-19
24966089-8	2014	Amiloride, an epithelial Na(+) channel (ENaC) inhibitor, normalized the BP of KO mice fed HK diets, suggesting that lack of Cyp2c44 in the CD enhances ENaC activity and increases Na(+) absorption in KO mice fed HK diets.	Amiloride	0-9	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	14-38
24966089-8	2014	Amiloride, an epithelial Na(+) channel (ENaC) inhibitor, normalized the BP of KO mice fed HK diets, suggesting that lack of Cyp2c44 in the CD enhances ENaC activity and increases Na(+) absorption in KO mice fed HK diets.	Amiloride	0-9	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	40-44
25347857-7	2014	The response to amiloride was reduced (41.6%) in the presence of NGF.	Amiloride	16-25	nerve growth factor	Homo sapiens	65-68
24846212-6	2014	Amiloride further ameliorated the NaCl avoidance of CALHM1 KO mice, so that lick rates to a mixture of 1000 mM NaCl + 10 microM amiloride were statistically indistinguishable from those to water.	Amiloride	0-9	calcium homeostasis modulator 1	Mus musculus	52-58
24885350-14	2014	This role of uPA in cell invasion was confirmed using the uPA inhibitors, amiloride and UK122.	Amiloride	74-83	plasminogen activator, urokinase	Homo sapiens	13-16
24573316-11	2014	Thus, the enhanced effect of amiloride on potassium secretion in wild-type compared to knockout mice on the alkaline diet clarify a BK- alpha/beta4-mediated potassium secretory pathway in intercalated cells driven by ENaC-mediated sodium reabsorption linked to bicarbonate secretion.	Amiloride	29-38	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	217-221
24318675-8	2014	Treatment with amiloride (an inhibitor of PM Na(+)/H(+) antiporter) and vanadate (an inhibitor of PM H(+)-ATPase) also inhibited the activity of H2S on Na(+)/K(+) ratio.	Amiloride	15-24	Na+/H+ exchanger 1	Arabidopsis thaliana	45-66
24553299-10	2014	Importantly, HO-1 induction enhanced migration (43 +- 5% of control, P &lt; 0.05), but the enhanced migratory response was entirely blocked by ENaC inhibition with amiloride (10 muM).	Amiloride	164-173	latexin	Homo sapiens	178-181
24105369-6	2014	We could observe an association of rare EHF haplotypes among homozygotes for c.1521_1523delCTT in CFTR, which exhibit a CF-untypical manifestation of the CF basic defect such as CFTR-mediated residual chloride secretion and low response to amiloride.	Amiloride	240-249	CF transmembrane conductance regulator	Homo sapiens	98-102
24303840-8	2014	F508 mice had considerably higher levels the amiloride-sensitive fractions of ENaC nasal potential difference (ENaC-NPD) than wild-type littermates and only background levels of IalphaI in their BALF.	Amiloride	45-54	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	78-82
24303840-8	2014	F508 mice had considerably higher levels the amiloride-sensitive fractions of ENaC nasal potential difference (ENaC-NPD) than wild-type littermates and only background levels of IalphaI in their BALF.	Amiloride	45-54	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	111-115
24105369-6	2014	We could observe an association of rare EHF haplotypes among homozygotes for c.1521_1523delCTT in CFTR, which exhibit a CF-untypical manifestation of the CF basic defect such as CFTR-mediated residual chloride secretion and low response to amiloride.	Amiloride	240-249	CF transmembrane conductance regulator	Homo sapiens	178-182
24506072-7	2014	Mutated KCNJ5 was less Ba(2+) and tertiapin-Q sensitive but was inhibited by blockers of Na(+) and Ca(2+)-transporting proteins, such as verapamil and amiloride.	Amiloride	151-160	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	8-13
24368771-5	2014	The demonstration that amiloride, an ENaC inhibitor, lowers the blood pressure of hypertensive Cyp2c44(-/-) mice identifies a role for the channel in the hypertensive phenotype of the animals.	Amiloride	23-32	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	37-41
24401990-7	2014	Activity of zNHE3b was inhibited by amiloride or 5-ethylisopropyl amiloride (EIPA).	Amiloride	36-45	solute carrier family 9 member A3, tandem duplicate 2	Danio rerio	12-18
24586504-0	2014	Selective activation of hTRPV1 by N-geranyl cyclopropylcarboxamide, an amiloride-insensitive salt taste enhancer.	Amiloride	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-30
24586504-11	2014	These data may provide additional support for our previous hypothesis that NGCC interacts with TRPV1 variant cation channel, a putative amiloride/benzamil-insensitive salt taste pathway in the anterior taste receptive field.	Amiloride	136-145	transient receptor potential cation channel subfamily V member 1	Homo sapiens	95-100
24368771-5	2014	The demonstration that amiloride, an ENaC inhibitor, lowers the blood pressure of hypertensive Cyp2c44(-/-) mice identifies a role for the channel in the hypertensive phenotype of the animals.	Amiloride	23-32	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	95-102
24283895-3	2014	OBJECTIVE: To evaluate whether treatment with amiloride (an inhibitor of u-PA) or antiplasmin attenuates synovitis and cartilage damage following joint bleeding in hemophilic mice.	Amiloride	46-55	plasminogen activator, urokinase	Mus musculus	73-77
24999355-5	2014	Molecularly, amiloride inhibited expression of cyclooxygenase-2 and matrix metallopeptidase-9 but not NHE-1 mRNA in esophageal cancer cells.	Amiloride	13-22	prostaglandin-endoperoxide synthase 2	Mus musculus	47-93
24999355-6	2014	A combination of amiloride and guggulsterone (a natural bile acid receptor inhibitor) showed more than additive effects in suppressing esophageal cancer cell growth in vitro and in nude mouse xenografts.	Amiloride	17-26	nuclear receptor subfamily 1, group H, member 4	Mus musculus	56-74
24005470-3	2013	After acid loading, in the presence of HCO3(-), ~50% of the pHi recovery phase was blocked by the Na(+)/H(+) exchanger inhibitors EIPA (10-50 muM) and amiloride (1 mM) and was fully cancelled by 30 muM EIPA under nominally HCO3(-)-free conditions.	Amiloride	151-160	glucose-6-phosphate isomerase	Homo sapiens	60-63
24603133-0	2014	PPARgamma-induced stimulation of amiloride-sensitive sodium current in renal collecting duct principal cells is serum and insulin dependent.	Amiloride	33-42	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
24603133-0	2014	PPARgamma-induced stimulation of amiloride-sensitive sodium current in renal collecting duct principal cells is serum and insulin dependent.	Amiloride	33-42	insulin	Homo sapiens	122-129
24097312-5	2014	Inhibitors of MPC, Cytochalasin D and amiloride, decreased P27-mediated uptake of soluble dextran and inhibited P27-induced virus uptake by &gt;60%, which provides further evidence that P27 induces MPC.	Amiloride	38-47	interferon alpha inducible protein 27	Homo sapiens	59-62
24097312-5	2014	Inhibitors of MPC, Cytochalasin D and amiloride, decreased P27-mediated uptake of soluble dextran and inhibited P27-induced virus uptake by &gt;60%, which provides further evidence that P27 induces MPC.	Amiloride	38-47	interferon alpha inducible protein 27	Homo sapiens	112-115
24097312-5	2014	Inhibitors of MPC, Cytochalasin D and amiloride, decreased P27-mediated uptake of soluble dextran and inhibited P27-induced virus uptake by &gt;60%, which provides further evidence that P27 induces MPC.	Amiloride	38-47	interferon alpha inducible protein 27	Homo sapiens	112-115
23732174-8	2013	In dorsal root ganglia neurons innervating muscle, incision increased mean current amplitudes of acid-evoked currents; the acid-sensing ion channel blocker, amiloride 300 muM, inhibited more than 75% of the acid-evoked current, whereas, the transient receptor vanilloid receptor 1 blocker (AMG9810 1 muM) did not cause significant inhibition.	Amiloride	157-166	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	260-280
23747564-4	2013	AGE-BSA-FITC uptake was significantly inhibited by amiloride and inhibitors of Arf6, Rac1, racGEF Tiam1, PAK1 and actin polymerisation.	Amiloride	51-60	TIAM Rac1 associated GEF 1	Sus scrofa	98-103
23747564-4	2013	AGE-BSA-FITC uptake was significantly inhibited by amiloride and inhibitors of Arf6, Rac1, racGEF Tiam1, PAK1 and actin polymerisation.	Amiloride	51-60	serine/threonine-protein kinase PAK 1	Sus scrofa	105-109
24312378-6	2013	Finally, we noted that albumin uptake in RPMEC was in part sensitive to pharmacological agents (amiloride [sodium transport inhibitor], Go6976 [protein kinase C inhibitor], and cytochalasin D [inhibitor of actin polymerization]) consistent with a macropinocytosis-like process.	Amiloride	96-105	albumin	Mus musculus	23-30
24312378-7	2013	The amiloride sensitivity accounting for macropinocytosis also exists in albumin uptake by both wild type and cav-1(-/-) MLEC.	Amiloride	4-13	albumin	Mus musculus	73-80
24312378-7	2013	The amiloride sensitivity accounting for macropinocytosis also exists in albumin uptake by both wild type and cav-1(-/-) MLEC.	Amiloride	4-13	caveolin 1, caveolae protein	Mus musculus	110-115
24102669-5	2013	Phenamil, an amiloride derivative, elicited higher ALP activity than quercetin.	Amiloride	13-22	alkaline phosphatase, placental	Homo sapiens	51-54
24100685-7	2013	Using whole-cell patch-clamp recordings, we detected an amiloride-sensitive current in GBM cells, and this current was significantly inhibited by both PcTX-1 and AIP.	Amiloride	56-65	aryl hydrocarbon receptor interacting protein	Homo sapiens	151-165
24019969-4	2013	A 20% bilateral hypotonic shock induced an immediate, but transient 52% rise in total transepithelial current and a 67% increase in the amiloride-sensitive current mediated by ENaC.	Amiloride	136-145	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	176-180
23864373-8	2013	These data demonstrate that the alpha1T gene encodes voltage-gated calcium channels underlying the amiloride-sensitive transient current.	Amiloride	99-108	Ca[2+]-channel protein alpha[[1]] subunit T	Drosophila melanogaster	32-39
24026424-5	2013	tPA was identified on the basis of the molecular weight, the immunoreactivity with relevant antibodies and the resistance to amiloride, a specific uPA inhibitor.	Amiloride	125-134	plasminogen activator, tissue type	Homo sapiens	0-3
24026424-6	2013	The secreted tPA activity measured by a chromogenic assay in the presence of amiloride was also inhibited by pepstatin at pH 6.6.	Amiloride	77-86	plasminogen activator, tissue type	Homo sapiens	13-16
24019969-5	2013	Amiloride pre-treatment decreased the current rise after hypotonic shock, showing that ENaC current is involved in this response.	Amiloride	0-9	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	87-91
23637203-5	2013	Amiloride-sensitive current in mammalian epithelia expressing ENaC was significantly reduced by COMMD3 or COMMD9, and ENaC expression at the cell surface was significantly decreased in the presence of COMMD3 or COMMD9.	Amiloride	0-9	COMM domain containing 3	Homo sapiens	96-102
23608591-3	2013	OBJECTIVE: To study the modulation of KCNQ1 alternative splicing by amiloride and the consequent changes in IKs and action potentials (APs) in ventricular myocytes.	Amiloride	68-77	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	38-43
23608591-6	2013	The effect of amiloride-induced changes in the KCNQ1b/total KCNQ1 ratio on AP was measured by using whole-cell patch clamp with and without isoproterenol.	Amiloride	14-23	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	47-52
23608591-12	2013	CONCLUSIONS: Amiloride regulates IKs and APs with transmural differences and reduces arrhythmogenicity through the modulation of KCNQ1 splicing.	Amiloride	13-22	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	129-134
23732645-8	2013	We find that while the loss of CFTR permeability hyperpolarises Vt and also increases amiloride-sensitive Vt, these effects are too small to account for the magnitude of change observed in CF epithelia.	Amiloride	86-95	CF transmembrane conductance regulator	Homo sapiens	31-35
23822711-0	2013	Modulating roles of amiloride in irradiation-induced antiproliferative effects in glioblastoma multiforme cells involving Akt phosphorylation and the alternative splicing of apoptotic genes.	Amiloride	20-29	AKT serine/threonine kinase 1	Homo sapiens	122-125
23822711-6	2013	The alternative splicing pattern of apoptotic protease-activating factor-1 (APAF1) in cells treated with amiloride alone, IR alone, and combined amiloride-IR treatments showed more consistent cell proliferation compared to that in other apoptosis-related genes such as baculoviral IAP repeat containing 5 (BIRC5), Bcl-X, and homeodomain interacting protein kinase-3 (HIPK3).	Amiloride	105-114	apoptotic peptidase activating factor 1	Homo sapiens	36-74
23822711-6	2013	The alternative splicing pattern of apoptotic protease-activating factor-1 (APAF1) in cells treated with amiloride alone, IR alone, and combined amiloride-IR treatments showed more consistent cell proliferation compared to that in other apoptosis-related genes such as baculoviral IAP repeat containing 5 (BIRC5), Bcl-X, and homeodomain interacting protein kinase-3 (HIPK3).	Amiloride	105-114	apoptotic peptidase activating factor 1	Homo sapiens	76-81
23822711-6	2013	The alternative splicing pattern of apoptotic protease-activating factor-1 (APAF1) in cells treated with amiloride alone, IR alone, and combined amiloride-IR treatments showed more consistent cell proliferation compared to that in other apoptosis-related genes such as baculoviral IAP repeat containing 5 (BIRC5), Bcl-X, and homeodomain interacting protein kinase-3 (HIPK3).	Amiloride	145-154	apoptotic peptidase activating factor 1	Homo sapiens	36-74
23822711-6	2013	The alternative splicing pattern of apoptotic protease-activating factor-1 (APAF1) in cells treated with amiloride alone, IR alone, and combined amiloride-IR treatments showed more consistent cell proliferation compared to that in other apoptosis-related genes such as baculoviral IAP repeat containing 5 (BIRC5), Bcl-X, and homeodomain interacting protein kinase-3 (HIPK3).	Amiloride	145-154	apoptotic peptidase activating factor 1	Homo sapiens	76-81
23822711-8	2013	Together, these results suggest that amiloride modulates cell radiosensitivity involving the Akt phosphorylation and the alternative splicing of APAF1, especially for the cells treated with amiloride with IR post-treatment.	Amiloride	37-46	AKT serine/threonine kinase 1	Homo sapiens	93-96
23822711-8	2013	Together, these results suggest that amiloride modulates cell radiosensitivity involving the Akt phosphorylation and the alternative splicing of APAF1, especially for the cells treated with amiloride with IR post-treatment.	Amiloride	37-46	apoptotic peptidase activating factor 1	Homo sapiens	145-150
23822711-8	2013	Together, these results suggest that amiloride modulates cell radiosensitivity involving the Akt phosphorylation and the alternative splicing of APAF1, especially for the cells treated with amiloride with IR post-treatment.	Amiloride	190-199	apoptotic peptidase activating factor 1	Homo sapiens	145-150
24023701-9	2013	Amiloride, a specific PLAU inhibitor, also suppressed these processes.	Amiloride	0-9	plasminogen activator, urokinase	Homo sapiens	22-26
23960454-8	2013	Spinal nerve ligation increased the expression of ASIC3 in the spinal cord dorsal horn (P=0.01), and this increase was inhibited by both amiloride and benzamil (P&lt;0.001 in both).	Amiloride	137-146	acid sensing ion channel subunit 3	Rattus norvegicus	50-55
23637203-5	2013	Amiloride-sensitive current in mammalian epithelia expressing ENaC was significantly reduced by COMMD3 or COMMD9, and ENaC expression at the cell surface was significantly decreased in the presence of COMMD3 or COMMD9.	Amiloride	0-9	COMM domain containing 9	Homo sapiens	106-112
23637203-5	2013	Amiloride-sensitive current in mammalian epithelia expressing ENaC was significantly reduced by COMMD3 or COMMD9, and ENaC expression at the cell surface was significantly decreased in the presence of COMMD3 or COMMD9.	Amiloride	0-9	COMM domain containing 3	Homo sapiens	201-207
23637203-5	2013	Amiloride-sensitive current in mammalian epithelia expressing ENaC was significantly reduced by COMMD3 or COMMD9, and ENaC expression at the cell surface was significantly decreased in the presence of COMMD3 or COMMD9.	Amiloride	0-9	COMM domain containing 9	Homo sapiens	211-217
23639808-0	2013	TRPM5-dependent amiloride- and benzamil-insensitive NaCl chorda tympani taste nerve response.	Amiloride	16-25	transient receptor potential cation channel, subfamily M, member 5	Mus musculus	0-5
23646172-0	2013	A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells.	Amiloride	16-25	apoptosis inducing factor mitochondria associated 1	Homo sapiens	66-69
23645634-9	2013	Inhibition of ENaC by amiloride reproduced alveolar fluid and Cl(-) secretion that were again CFTR-, NKCC-, and Na(+)-K(+)-ATPase-dependent.	Amiloride	22-31	cystic fibrosis transmembrane conductance regulator	Mus musculus	94-98
23313096-0	2013	AP301, a synthetic peptide mimicking the lectin-like domain of TNF, enhances amiloride-sensitive Na(+) current in primary dog, pig and rat alveolar type II cells.	Amiloride	77-86	tumor necrosis factor	Canis lupus familiaris	63-66
23313096-4	2013	Cell-based electrophysiological studies have revealed that the alveolar fluid clearing capacity of TNF and the TIP peptides is due to activation of the amiloride-sensitive Na(+) current in alveolar epithelial cells and that the primary site of action is on the apical side of these cells.	Amiloride	152-161	tumor necrosis factor	Canis lupus familiaris	99-102
23658159-6	2013	Mobilization of trkA to the membrane at pH 6.5 was abolished in neurons treated with the acid-sensitive ion channel blocker, amiloride.	Amiloride	125-134	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	16-20
23436042-8	2013	Finally, loss-of-function mutations in mec-4 and mec-10, which are amiloride-sensitive Na(+) channel genes expressed in all six gentle touch neurons, accelerated the velocity of DAF-16 nuclear localization, induced by confined space, revealing that mec-4/mec-10 were not required for this stress response.	Amiloride	67-76	Degenerin mec-4	Caenorhabditis elegans	39-44
23306556-7	2013	Pharmacological pan-inhibition of ASIC channels with the lipophilic amiloride derivative, 5-(N,N-dimethyl)-amiloride hydrochloride, potently protected cultured motoneurons against acidotoxicity, and, given post-symptom onset, significantly improved lifespan, motor performance and motoneuron survival in SOD1 mice.	Amiloride	68-77	acid-sensing (proton-gated) ion channel 1	Mus musculus	34-38
23306556-7	2013	Pharmacological pan-inhibition of ASIC channels with the lipophilic amiloride derivative, 5-(N,N-dimethyl)-amiloride hydrochloride, potently protected cultured motoneurons against acidotoxicity, and, given post-symptom onset, significantly improved lifespan, motor performance and motoneuron survival in SOD1 mice.	Amiloride	68-77	superoxide dismutase 1, soluble	Mus musculus	304-308
23575826-3	2013	Gustatory nerve recording demonstrated that AngII suppressed amiloride-sensitive taste responses to NaCl.	Amiloride	61-70	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	44-49
23575826-9	2013	The specific reduction of amiloride-sensitive salt taste sensitivity by AngII may contribute to increased sodium intake.	Amiloride	26-35	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	72-77
23436042-8	2013	Finally, loss-of-function mutations in mec-4 and mec-10, which are amiloride-sensitive Na(+) channel genes expressed in all six gentle touch neurons, accelerated the velocity of DAF-16 nuclear localization, induced by confined space, revealing that mec-4/mec-10 were not required for this stress response.	Amiloride	67-76	Degenerin mec-10	Caenorhabditis elegans	49-55
23436042-8	2013	Finally, loss-of-function mutations in mec-4 and mec-10, which are amiloride-sensitive Na(+) channel genes expressed in all six gentle touch neurons, accelerated the velocity of DAF-16 nuclear localization, induced by confined space, revealing that mec-4/mec-10 were not required for this stress response.	Amiloride	67-76	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	178-184
23152295-4	2013	Our results indicate that amiloride enhances Ca(2+) reabsorption in the DCT2-CNT predominantly by increasing the driving force across NCX1, thereby stimulating Ca(2+) efflux.	Amiloride	26-35	solute carrier family 8 member A1	Homo sapiens	134-138
23216619-11	2013	In this study, it is shown that human lymphocytes may be used to uncover the effect of urine plasmin on amiloride- and aprotinin-sensitive inward currents.	Amiloride	104-113	plasminogen	Homo sapiens	93-100
23135700-8	2013	Transepithelial current measurements showed an acute increase of amiloride-sensitive current through the mpkCCD(c14) monolayer in response to EGF, insulin, or IGF-1.	Amiloride	65-74	insulin-like growth factor 1	Mus musculus	159-164
23083067-9	2013	Pretreating the apical membrane with amiloride, which inhibits ENaC, completely prevented the stimulating effects of benzimidazolones on I(SC).	Amiloride	37-46	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	63-67
23329732-6	2013	Other tested insect ORs (Drosophila Or49b + DmelOrco, B. mori BmorOr1 + BmorOrco) were blocked in a similar fashion suggesting that the amiloride derivatives were potential general blockers of all receptor combinations.	Amiloride	136-145	Odorant receptor 49b	Drosophila melanogaster	36-41
23329732-6	2013	Other tested insect ORs (Drosophila Or49b + DmelOrco, B. mori BmorOr1 + BmorOrco) were blocked in a similar fashion suggesting that the amiloride derivatives were potential general blockers of all receptor combinations.	Amiloride	136-145	Odorant receptor co-receptor	Drosophila melanogaster	44-52
23274414-14	2013	In ApoE(-/-) mice, administration of amiloride significantly suppressed LPS-accelerated atherosclerosis and LPS-induced increase of NHE1 activity, and reversed LPS-induced down-regulation of Bcl-2 expression.	Amiloride	37-46	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	132-136
23274414-14	2013	In ApoE(-/-) mice, administration of amiloride significantly suppressed LPS-accelerated atherosclerosis and LPS-induced increase of NHE1 activity, and reversed LPS-induced down-regulation of Bcl-2 expression.	Amiloride	37-46	toll-like receptor 4	Mus musculus	108-111
23274414-14	2013	In ApoE(-/-) mice, administration of amiloride significantly suppressed LPS-accelerated atherosclerosis and LPS-induced increase of NHE1 activity, and reversed LPS-induced down-regulation of Bcl-2 expression.	Amiloride	37-46	B cell leukemia/lymphoma 2	Mus musculus	191-196
23274414-16	2013	Amiloride inhibits NHE1 activity, thus attenuates LPS-accelerated atherosclerosis in mice.	Amiloride	0-9	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	19-23
23274414-16	2013	Amiloride inhibits NHE1 activity, thus attenuates LPS-accelerated atherosclerosis in mice.	Amiloride	0-9	toll-like receptor 4	Mus musculus	50-53
23274414-0	2013	Amiloride attenuates lipopolysaccharide-accelerated atherosclerosis via inhibition of NHE1-dependent endothelial cell apoptosis.	Amiloride	0-9	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	86-90
23274414-1	2013	AIM: To investigate the effects of the potassium-sparing diuretic amiloride on endothelial cell apoptosis during lipopolysaccharide (LPS)-accelerated atherosclerosis.	Amiloride	66-75	toll-like receptor 4	Mus musculus	133-136
23274414-7	2013	Amiloride (1-10 mumol/L) significantly suppressed LPS-induced increases in NHE1 activity, [Ca(2+)](i).	Amiloride	0-9	toll-like receptor 4	Mus musculus	50-53
23274414-7	2013	Amiloride (1-10 mumol/L) significantly suppressed LPS-induced increases in NHE1 activity, [Ca(2+)](i).	Amiloride	0-9	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	75-79
23274414-11	2013	In the presence of amiloride (10 mumol/L) or the calpain inhibitor ZLLal (50 mumol/L), the down-regulation of Bcl-2 protein by LPS was blocked.	Amiloride	19-28	B cell leukemia/lymphoma 2	Mus musculus	110-115
23274414-11	2013	In the presence of amiloride (10 mumol/L) or the calpain inhibitor ZLLal (50 mumol/L), the down-regulation of Bcl-2 protein by LPS was blocked.	Amiloride	19-28	toll-like receptor 4	Mus musculus	127-130
23274414-13	2013	In the presence of amiloride, BAPTA or ZLLal, LPS-induced HUVEC apoptosis was significantly attenuated.	Amiloride	19-28	toll-like receptor 4	Mus musculus	46-49
23274414-14	2013	In ApoE(-/-) mice, administration of amiloride significantly suppressed LPS-accelerated atherosclerosis and LPS-induced increase of NHE1 activity, and reversed LPS-induced down-regulation of Bcl-2 expression.	Amiloride	37-46	apolipoprotein E	Mus musculus	3-7
23274414-14	2013	In ApoE(-/-) mice, administration of amiloride significantly suppressed LPS-accelerated atherosclerosis and LPS-induced increase of NHE1 activity, and reversed LPS-induced down-regulation of Bcl-2 expression.	Amiloride	37-46	toll-like receptor 4	Mus musculus	72-75
23274414-14	2013	In ApoE(-/-) mice, administration of amiloride significantly suppressed LPS-accelerated atherosclerosis and LPS-induced increase of NHE1 activity, and reversed LPS-induced down-regulation of Bcl-2 expression.	Amiloride	37-46	toll-like receptor 4	Mus musculus	108-111
23324889-0	2013	Activation of the heat shock response attenuates the interleukin 1beta-mediated inhibition of the amiloride-sensitive alveolar epithelial ion transport.	Amiloride	98-107	interleukin 1 beta	Rattus norvegicus	53-70
23171553-11	2013	However, amiloride did prevent decreases in ENaC expression, an effect that was not mimicked by hydrochlorothiazide administration.	Amiloride	9-18	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	44-48
23135700-10	2013	To further test whether NADPH oxidase subunits are involved in the effect of EGF, we used a stable M-1 cell line with a knockdown of Rac1, which is one of the key subunits of the NADPH oxidase complex, and measured amiloride-sensitive currents in response to EGF.	Amiloride	215-224	Rac family small GTPase 1	Mus musculus	133-137
22966789-2	2013	We wanted to test the hypotheses that amiloride and spironolactone induced potassium retention reduces ambulatory blood pressure (ABP) and central blood pressure (CBP) during baseline conditions and after furosemide and that the tubular transport via the epithelial sodium channels (ENaCs) and aquaporin-2 (AQP2) water channels was increased by furosemide in arterial hypertension.	Amiloride	38-47	aquaporin 2	Homo sapiens	294-305
23365093-0	2013	Targeting ASIC1 in primary progressive multiple sclerosis: evidence of neuroprotection with amiloride.	Amiloride	92-101	acid sensing ion channel subunit 1	Homo sapiens	10-15
23365093-5	2013	While blockade of ASIC1 through amiloride, a potassium sparing diuretic that is currently licensed for hypertension and congestive cardiac failure, showed neuroprotective and myeloprotective effects in experimental models of multiple sclerosis, this strategy remains untested in patients with multiple sclerosis.	Amiloride	32-41	acid sensing ion channel subunit 1	Homo sapiens	18-23
22966789-2	2013	We wanted to test the hypotheses that amiloride and spironolactone induced potassium retention reduces ambulatory blood pressure (ABP) and central blood pressure (CBP) during baseline conditions and after furosemide and that the tubular transport via the epithelial sodium channels (ENaCs) and aquaporin-2 (AQP2) water channels was increased by furosemide in arterial hypertension.	Amiloride	38-47	aquaporin 2	Homo sapiens	307-311
24281140-7	2013	RESULTS: The amiloride (50 microM)-induced deflection of the transepithelial potential difference was significantly lower and fecal Na(+) excretion significantly higher in jak3(-/-) mice than in jak3(+/+) mice.	Amiloride	13-22	Janus kinase 3	Mus musculus	172-176
24281140-7	2013	RESULTS: The amiloride (50 microM)-induced deflection of the transepithelial potential difference was significantly lower and fecal Na(+) excretion significantly higher in jak3(-/-) mice than in jak3(+/+) mice.	Amiloride	13-22	Janus kinase 3	Mus musculus	195-199
23019198-4	2012	OSR1 protein abundance was determined by Western blotting, cytosolic pH from BCECF fluorescence, NHE activity from Na(+)-dependent realkalinization following an ammonium pulse, SGLT1 activity from glucose-induced current, and colonic ENaC activity from amiloride-sensitive transepithelial current in Ussing chamber experiments.	Amiloride	253-262	odd-skipped related transcription factor 1	Mus musculus	0-4
23234499-0	2012	u-PA inhibitor amiloride suppresses peritoneal metastasis in gastric cancer.	Amiloride	15-24	plasminogen activator, urokinase	Homo sapiens	0-4
23234499-4	2012	METHODS: In the present study, we evaluated the effects and explored the anti-tumor mechanisms of amiloride, a selective u-PA inhibitor, on a panel of gastric cancer cell lines and in a murine model of human gastric cancer MKN45.	Amiloride	98-107	plasminogen activator, urokinase	Mus musculus	121-125
23234499-6	2012	In vitro, compared with controls, amiloride could not only significantly down-regulate the mRNA expression and protein level of u-PA from MKN45 cells with dose dependence but also inhibit the adhesion of HMrSV5 cells, migration and invasion of MKN45 cells.	Amiloride	34-43	plasminogen activator, urokinase	Homo sapiens	128-132
23234499-7	2012	CONCLUSIONS: The findings in our current report provide evidence that selective u-PA inhibitor amiloride has potent effects against peritoneal metastasis in gastric cancer, suggesting its possible therapeutic value for the treatment of gastric cancer.	Amiloride	95-104	plasminogen activator, urokinase	Homo sapiens	80-84
22700868-6	2012	The administration of ouabain (a Na,K-ATPase inhibitor) and amiloride (a Na(+) channel blocker) inhibited the stimulatory effects of vasopressin (from 0.64 +- 0.02 to 0.22 +- 0.02 ml/h [P &lt; 0.0001] and from 0.64 +- 0.017 to 0.23 +- 0.02 ml/h [P &lt; 0.0001], respectively).	Amiloride	60-69	arginine vasopressin	Rattus norvegicus	133-144
23054171-2	2012	Whereas electrophysiological evidence from the chorda tympani nerve (CT) has implicated the transient receptor potential vanilloid-1 (TRPV1) channel as a major component of amiloride-insensitive salt taste transduction, behavioral results have provided only equivocal support.	Amiloride	173-182	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	92-132
23054171-2	2012	Whereas electrophysiological evidence from the chorda tympani nerve (CT) has implicated the transient receptor potential vanilloid-1 (TRPV1) channel as a major component of amiloride-insensitive salt taste transduction, behavioral results have provided only equivocal support.	Amiloride	173-182	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	134-139
23054171-4	2012	Both LiCl-injected WT and TRPV1 KO groups learned to avoid NaCl+amiloride relative to controls, but their generalization profiles did not differ; LiCl-injected mice avoided the nonsodium salts and quinine suggesting that a TRPV1-independent pathway contributes to the taste quality of the amiloride-insensitive portion of the NaCl signal.	Amiloride	64-73	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	26-31
23085555-3	2012	This current was completely suppressed when 1 muM amiloride was applied before adding the bactridines.	Amiloride	50-59	latexin	Homo sapiens	46-49
23085555-4	2012	Since the amiloride sensitive current is able to distort the aim of our study, i.e. the effect of bactridines on sodium channels, all experiments were done in the presence of 1 muM amiloride.	Amiloride	10-19	latexin	Homo sapiens	177-180
22591391-9	2012	The amiloride-sensitive Na(+) currents in hyperoxia-exposed ATII cells were also increased, which was consistent with the upregulated expression of beta- and gamma-ENaC.	Amiloride	4-13	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	164-168
22683701-6	2012	In addition, FN-induced increase of cell migration was inhibited by NHE-1 inhibitor amiloride or NHE-1-specific siRNA.	Amiloride	84-93	fibronectin 1	Mus musculus	13-15
22932914-3	2012	This group of mostly monogenic and acquired disorders typically causes hypertension through activation of the mineralocorticoid receptor either directly or indirectly via hormonal mediators and from overactive amiloride-sensitive epithelial sodium channels located in the distal tubule and collecting ducts of the kidneys.	Amiloride	210-219	nuclear receptor subfamily 3 group C member 2	Homo sapiens	110-136
23109150-3	2012	RESULTS: Amiloride was shown to block cortical spreading depression, the experimental correlate of aura, and inhibited trigeminal activation in in vivo migraine models, via an acid-sensing ion channel 1 mechanism.	Amiloride	9-18	acid sensing ion channel subunit 1	Homo sapiens	176-202
22683701-6	2012	In addition, FN-induced increase of cell migration was inhibited by NHE-1 inhibitor amiloride or NHE-1-specific siRNA.	Amiloride	84-93	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	68-73
22767612-2	2012	Amiloride was the first organic blocker to selectively block the native T-type calcium channel, but the potency and mechanism of block of this drug on the three recombinant T-type calcium channels (Ca(V)3.1, Ca(V)3.2, and Ca(V)3.3) have not been systematically determined.	Amiloride	0-9	immunoglobulin lambda variable 7-43	Homo sapiens	208-216
22767612-2	2012	Amiloride was the first organic blocker to selectively block the native T-type calcium channel, but the potency and mechanism of block of this drug on the three recombinant T-type calcium channels (Ca(V)3.1, Ca(V)3.2, and Ca(V)3.3) have not been systematically determined.	Amiloride	0-9	immunoglobulin lambda variable 7-46	Homo sapiens	222-230
22767612-0	2012	Block of human CaV3 channels by the diuretic amiloride.	Amiloride	45-54	caveolin 3	Homo sapiens	15-19
22767612-3	2012	The aim of the present study was to investigate whether there is differential block of Ca(V)3 channels by amiloride, to establish the mechanism of block, and to obtain insights into the amiloride putative binding sites in Ca(V)3 channels.	Amiloride	106-115	caveolin 3	Homo sapiens	87-93
22767612-3	2012	The aim of the present study was to investigate whether there is differential block of Ca(V)3 channels by amiloride, to establish the mechanism of block, and to obtain insights into the amiloride putative binding sites in Ca(V)3 channels.	Amiloride	186-195	caveolin 3	Homo sapiens	222-228
22767612-4	2012	By performing whole-cell patch-clamp recordings of human embryonic kidney 293 cells stably expressing human Ca(V)3 channels, we found that amiloride blocked the human Ca(V)3 channels in a concentration-response manner; the IC50 for Ca(V)3.2 channels (62 muM) was 13-fold lower than that for Ca(V)3.1 and Ca(V)3.3.	Amiloride	139-148	caveolin 3	Homo sapiens	108-114
22767612-4	2012	By performing whole-cell patch-clamp recordings of human embryonic kidney 293 cells stably expressing human Ca(V)3 channels, we found that amiloride blocked the human Ca(V)3 channels in a concentration-response manner; the IC50 for Ca(V)3.2 channels (62 muM) was 13-fold lower than that for Ca(V)3.1 and Ca(V)3.3.	Amiloride	139-148	caveolin 3	Homo sapiens	167-173
22767612-4	2012	By performing whole-cell patch-clamp recordings of human embryonic kidney 293 cells stably expressing human Ca(V)3 channels, we found that amiloride blocked the human Ca(V)3 channels in a concentration-response manner; the IC50 for Ca(V)3.2 channels (62 muM) was 13-fold lower than that for Ca(V)3.1 and Ca(V)3.3.	Amiloride	139-148	immunoglobulin lambda variable 7-43	Homo sapiens	232-240
22767612-4	2012	By performing whole-cell patch-clamp recordings of human embryonic kidney 293 cells stably expressing human Ca(V)3 channels, we found that amiloride blocked the human Ca(V)3 channels in a concentration-response manner; the IC50 for Ca(V)3.2 channels (62 muM) was 13-fold lower than that for Ca(V)3.1 and Ca(V)3.3.	Amiloride	139-148	latexin	Homo sapiens	254-257
22767612-4	2012	By performing whole-cell patch-clamp recordings of human embryonic kidney 293 cells stably expressing human Ca(V)3 channels, we found that amiloride blocked the human Ca(V)3 channels in a concentration-response manner; the IC50 for Ca(V)3.2 channels (62 muM) was 13-fold lower than that for Ca(V)3.1 and Ca(V)3.3.	Amiloride	139-148	calcium voltage-gated channel subunit alpha1 G	Homo sapiens	291-299
22767612-4	2012	By performing whole-cell patch-clamp recordings of human embryonic kidney 293 cells stably expressing human Ca(V)3 channels, we found that amiloride blocked the human Ca(V)3 channels in a concentration-response manner; the IC50 for Ca(V)3.2 channels (62 muM) was 13-fold lower than that for Ca(V)3.1 and Ca(V)3.3.	Amiloride	139-148	immunoglobulin lambda variable 7-46	Homo sapiens	304-312
22767612-7	2012	The results demonstrate that amiloride blocks human Ca(V)3 channels differentially through a mechanism involving mainly the closed state of the channel and suggest a negative allosteric interaction with at least two putative binding sites with different affinities.	Amiloride	29-38	caveolin 3	Homo sapiens	52-58
22767612-8	2012	The preferential block of Ca(V)3.2 channels labels amiloride as the only organic blocker to be selective for any T-type channel.	Amiloride	51-60	immunoglobulin lambda variable 7-43	Homo sapiens	26-34
22702502-6	2012	RESULTS: Lactic acid at pH 7.03 induced a significant rise in nasal fluid secretion that was inhibited by pre-treatment with the ASIC inhibitor amiloride in AR subjects (n = 19).	Amiloride	144-153	acid sensing ion channel subunit 1	Homo sapiens	129-133
22864553-7	2012	We demonstrated that Cat-S activates amiloride-sensitive whole-cell currents in ENaC-expressing oocytes.	Amiloride	37-46	cathepsin S	Homo sapiens	21-26
22622459-5	2012	Urinary proteins reconstituted in a low-Na buffer activated amiloride-sensitive currents (I(Na)) in ENaC-expressing oocytes, suggesting an endogenous urinary protease can activate ENaC.	Amiloride	60-69	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	100-104
22622459-5	2012	Urinary proteins reconstituted in a low-Na buffer activated amiloride-sensitive currents (I(Na)) in ENaC-expressing oocytes, suggesting an endogenous urinary protease can activate ENaC.	Amiloride	60-69	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	180-184
22168390-9	2012	Furthermore, amiloride partly restored the levels of mitochondrial membrane potential by regulation of Bcl-2 family gene mRNA expression, and activity of caspase 3/9 in chondrocytes induced by extracellular acid.	Amiloride	13-22	BCL2, apoptosis regulator	Rattus norvegicus	103-108
22168390-9	2012	Furthermore, amiloride partly restored the levels of mitochondrial membrane potential by regulation of Bcl-2 family gene mRNA expression, and activity of caspase 3/9 in chondrocytes induced by extracellular acid.	Amiloride	13-22	caspase 3	Rattus norvegicus	154-163
22648244-10	2012	Amiloride (Ami), an antagonist of ASIC3, strengthened the antinociceptive effect of Ost.	Amiloride	0-9	acid sensing ion channel subunit 3	Rattus norvegicus	34-39
22634011-7	2012	Amiloride, an inhibitor of uPA, markedly reduced staurosporine-induced Tuj-1 staining, neurite length, neurite number, and uPA staining versus controls.	Amiloride	0-9	plasminogen activator, urokinase	Gallus gallus	27-30
22634011-7	2012	Amiloride, an inhibitor of uPA, markedly reduced staurosporine-induced Tuj-1 staining, neurite length, neurite number, and uPA staining versus controls.	Amiloride	0-9	plasminogen activator, urokinase	Gallus gallus	123-126
22634011-8	2012	In developing retinas in ovo, amiloride administration remarkably reduced the staurosporine-induced uPA staining and RGC differentiation.	Amiloride	30-39	plasminogen activator, urokinase	Gallus gallus	100-103
22526458-6	2012	We found that expression of SERP1 strongly inhibits amiloride-sensitive Na(+) transport.	Amiloride	52-61	stress associated endoplasmic reticulum protein 1	Homo sapiens	28-33
22648244-10	2012	Amiloride (Ami), an antagonist of ASIC3, strengthened the antinociceptive effect of Ost.	Amiloride	0-3	acid sensing ion channel subunit 3	Rattus norvegicus	34-39
22357920-7	2012	Inhibition of epithelial Na channel (ENaC) with amiloride or benzamil abolished the flow response, suggesting involvement of ENaC in flow-regulated ET-1 synthesis.	Amiloride	48-57	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	37-41
22357920-7	2012	Inhibition of epithelial Na channel (ENaC) with amiloride or benzamil abolished the flow response, suggesting involvement of ENaC in flow-regulated ET-1 synthesis.	Amiloride	48-57	endothelin 1	Mus musculus	148-152
22421400-9	2012	Amiloride (0.3 muM) reduced the acid-evoked ATP release by approximately 70%, while capsazepine (10 muM) reduced acid-evoked ATP release at pH 6.0 and pH 5.6 (by 68% and 61%, respectively).	Amiloride	0-9	latexin	Homo sapiens	15-18
22425452-5	2012	As such, pyrazinoyl quaternary amines represent a promising new class of ENaC blockers for the treatment of cystic fibrosis that are structurally distinct from the pyrazinoyl guanidine chemotype found in prototypical ENaC blockers such as amiloride.	Amiloride	239-248	amiloride-sensitive sodium channel subunit alpha	Cavia porcellus	73-77
22076430-3	2012	Here we show that podocyte uPAR expression can be reduced using amiloride.	Amiloride	64-73	plasminogen activator, urokinase receptor	Mus musculus	27-31
22076430-5	2012	Amiloride inhibited the induction of uPAR protein and PLAUR messenger RNA (encoding uPAR) and with that it reduced uPAR-mediated beta3 integrin activation in lipopolysaccharide (LPS)-treated podocytes.	Amiloride	0-9	plasminogen activator, urokinase receptor	Mus musculus	37-41
22076430-5	2012	Amiloride inhibited the induction of uPAR protein and PLAUR messenger RNA (encoding uPAR) and with that it reduced uPAR-mediated beta3 integrin activation in lipopolysaccharide (LPS)-treated podocytes.	Amiloride	0-9	plasminogen activator, urokinase receptor	Mus musculus	54-59
22076430-5	2012	Amiloride inhibited the induction of uPAR protein and PLAUR messenger RNA (encoding uPAR) and with that it reduced uPAR-mediated beta3 integrin activation in lipopolysaccharide (LPS)-treated podocytes.	Amiloride	0-9	plasminogen activator, urokinase receptor	Mus musculus	84-88
22076430-5	2012	Amiloride inhibited the induction of uPAR protein and PLAUR messenger RNA (encoding uPAR) and with that it reduced uPAR-mediated beta3 integrin activation in lipopolysaccharide (LPS)-treated podocytes.	Amiloride	0-9	plasminogen activator, urokinase receptor	Mus musculus	84-88
22076430-8	2012	Amiloride was also effective in the LPS mouse model of transient proteinuria (LPS mice) and in the 5/6 nephrectomy rat FSGS model (NTX) by significantly inhibiting podocyte uPAR induction, reducing proteinuria.	Amiloride	0-9	plasminogen activator, urokinase receptor	Rattus norvegicus	173-177
22076430-10	2012	Thus, our observations show that amiloride inhibits podocyte uPAR induction and reduces proteinuria in NTX rats and LPS mice.	Amiloride	33-42	plasminogen activator, urokinase receptor	Rattus norvegicus	61-65
22076430-11	2012	Given the pathological relevance of the uPAR-beta3 integrin signaling axis in FSGS, amiloride may be utilized in patients with FSGS.	Amiloride	84-93	plasminogen activator, urokinase receptor	Rattus norvegicus	40-44
22237475-12	2012	Amiloride also inhibited calpain and calcineurin expression levels in acid-induced chondrocytes, and inhibited caspase-3 activity.	Amiloride	0-9	caspase 3	Rattus norvegicus	111-120
22227200-5	2012	The IGF-1-induced increment of J(ms)Na and J(net)Na was inhibited by mucosal amiloride (1 mmol l(-1)).	Amiloride	77-86	insulin-like growth factor I	Ovis aries	4-9
22227200-11	2012	Amiloride administration reduced the recovery rate in both control and IGF-1-stimulated cells.	Amiloride	0-9	insulin-like growth factor I	Ovis aries	71-76
22366654-1	2012	The relative non-toxicity of the diuretic amiloride, coupled with its selective inhibition of the protease urokinase plasminogen activator (uPA), makes this compound class attractive for structure-activity studies.	Amiloride	42-51	plasminogen activator, urokinase	Homo sapiens	107-138
22366654-1	2012	The relative non-toxicity of the diuretic amiloride, coupled with its selective inhibition of the protease urokinase plasminogen activator (uPA), makes this compound class attractive for structure-activity studies.	Amiloride	42-51	plasminogen activator, urokinase	Homo sapiens	140-143
22090066-10	2012	Finally, MLC(20) increased when the intraluminal pressure was raised, and the pressure-induced increase in MLC(20) phosphorylation was inhibited by pretreatment with amiloride, and in arteries transfected with betaENaC or gammaENaC small interfering RNA.	Amiloride	166-175	myosin light chain 12B	Rattus norvegicus	9-15
22090066-10	2012	Finally, MLC(20) increased when the intraluminal pressure was raised, and the pressure-induced increase in MLC(20) phosphorylation was inhibited by pretreatment with amiloride, and in arteries transfected with betaENaC or gammaENaC small interfering RNA.	Amiloride	166-175	myosin light chain 12B	Rattus norvegicus	107-113
21956615-1	2012	UNLABELLED: Severe and reproducible low-renin hypertension responsive to salt restriction and amiloride-thiazide therapy in a 13-year-old otherwise asymptomatic boy suggested Liddle syndrome.	Amiloride	94-103	renin	Homo sapiens	40-45
22169010-2	2012	Application of 50 nM ANG II increased ENaC activity, defined by NP(o) (a product of channel numbers and open probability), and the amiloride-sensitive whole cell Na currents by twofold.	Amiloride	131-140	angiotensinogen	Rattus norvegicus	21-27
22183725-6	2012	Recordings from newly generated mutant flies demonstrated that DmalphaG (Ca(v)3 homolog) encoded the amiloride-sensitive portion of the transient LVA calcium current.	Amiloride	101-110	Ca[2+]-channel protein alpha[[1]] subunit T	Drosophila melanogaster	63-71
22183725-7	2012	We further demonstrated that the Ca(v)2 homolog, Dmca1A, mediated the amiloride-insensitive component of LVA current.	Amiloride	70-79	cacophony	Drosophila melanogaster	49-55
22184322-8	2012	Moreover, application of amiloride abolished the HK-induced hypertension in Cyp2c44(-/-) mice.	Amiloride	25-34	cytochrome P450, family 2, subfamily c, polypeptide 23	Mus musculus	76-83
22079595-8	2012	Neither cAMP nor Ca(2+)-induced secretion of Cl(-) was affected in the EDC or LDC of Clcn2(-/-) mice, whereas the amiloride-sensitive short-circuit current was increased approximately 3-fold in Clcn2(-/-) EDC compared with control littermates.	Amiloride	114-123	chloride channel, voltage-sensitive 2	Mus musculus	194-199
22079595-11	2012	The increase in the amiloride-sensitive short-circuit current in Clcn2(-/-) mice revealed a compensatory mechanism that is activated in the colons of mice that lack the ClC-2 channel.	Amiloride	20-29	chloride channel, voltage-sensitive 2	Mus musculus	65-70
22079595-11	2012	The increase in the amiloride-sensitive short-circuit current in Clcn2(-/-) mice revealed a compensatory mechanism that is activated in the colons of mice that lack the ClC-2 channel.	Amiloride	20-29	chloride channel, voltage-sensitive 2	Mus musculus	169-174
22008743-6	2012	Mice conditioned using CTA methods to avoid either MSG or MPG showed aversive responses to MSG with and without amiloride or to MPG, respectively, at concentrations of 0.0001 mM and above.	Amiloride	112-121	N-methylpurine-DNA glycosylase	Mus musculus	58-61
22197144-2	2012	We report the identification of a novel series of human epithelial sodium channel (ENaC) blockers that are structurally distinct from the pyrazinoyl guanidine chemotype found in prototypical ENaC blockers such as amiloride.	Amiloride	213-222	amiloride-sensitive sodium channel subunit alpha	Cavia porcellus	83-87
22020092-5	2012	Furthermore, we also found that higher Ang-2 levels were associated with more successful locomotor recovery after SCI, both in SCI rats with markedly better spontaneous motor recovery and in SCI rats receiving a neuroprotective pharmacological intervention (amiloride), suggesting a beneficial role for Ang-2 in injured spinal cords.	Amiloride	258-267	angiogenin, ribonuclease A family, member 2	Rattus norvegicus	39-44
21949158-8	2012	Addition of PMA and ionomycin with the epithelial Na(+) channel (ENaC) blocker amiloride had no additional inhibitory effect.	Amiloride	79-88	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	39-63
22302997-10	2012	In non-capacitated sperm, amiloride, an ENaC inhibitor, and genistein, a CFTR activator, caused a decrease in [Na+](i), suggesting that also in these cells [Na+](i) is dependent on the crosstalk between ENaC and CFTR.	Amiloride	26-35	CF transmembrane conductance regulator	Homo sapiens	212-216
21949158-8	2012	Addition of PMA and ionomycin with the epithelial Na(+) channel (ENaC) blocker amiloride had no additional inhibitory effect.	Amiloride	79-88	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	65-69
22904641-8	2012	The amiloride analog 5-(N-methyl-N-isobutyl)-amiloride (MIA) blocked short-term NHE activation and inhibited ERK phosphorylation, suggesting that NHE is critical for ERK activation by BK.	Amiloride	4-13	solute carrier family 9 member C1	Homo sapiens	80-83
22904641-8	2012	The amiloride analog 5-(N-methyl-N-isobutyl)-amiloride (MIA) blocked short-term NHE activation and inhibited ERK phosphorylation, suggesting that NHE is critical for ERK activation by BK.	Amiloride	4-13	mitogen-activated protein kinase 1	Homo sapiens	109-112
22904641-8	2012	The amiloride analog 5-(N-methyl-N-isobutyl)-amiloride (MIA) blocked short-term NHE activation and inhibited ERK phosphorylation, suggesting that NHE is critical for ERK activation by BK.	Amiloride	4-13	solute carrier family 9 member C1	Homo sapiens	146-149
22904641-8	2012	The amiloride analog 5-(N-methyl-N-isobutyl)-amiloride (MIA) blocked short-term NHE activation and inhibited ERK phosphorylation, suggesting that NHE is critical for ERK activation by BK.	Amiloride	4-13	mitogen-activated protein kinase 1	Homo sapiens	166-169
22904641-8	2012	The amiloride analog 5-(N-methyl-N-isobutyl)-amiloride (MIA) blocked short-term NHE activation and inhibited ERK phosphorylation, suggesting that NHE is critical for ERK activation by BK.	Amiloride	4-13	kininogen 1	Homo sapiens	184-186
22591021-1	2012	We wanted to test the hypothesis that treatment with amiloride or spironolactone reduced ambulatory (ABP) and central blood pressure (CBP) and that tubular transport via ENaCgamma and AQP2 was increased after furosemide treatment.	Amiloride	53-62	amine oxidase copper containing 1	Homo sapiens	101-104
21911609-5	2011	In contrast, the non-selective ASIC and Na(+)-H(+) exchanger (NHE1) antagonists, amiloride and its analogues, suppressed nicotine-evoked responses in MHb neurones of wild-type and ASIC2 null mice, excluding a possible involvement of ASIC2 in the nAChR inhibition by amiloride.	Amiloride	81-90	acid-sensing (proton-gated) ion channel 1	Mus musculus	31-35
22697478-1	2012	The lectin-like domain of Tumor Necrosis Factor (TNF), mimicked by the TIP peptide, activates amiloride-sensitive sodium uptake in type II alveolar epithelial cells and as such increases alveolar liquid clearance in dysfunctional lungs.	Amiloride	94-103	tumor necrosis factor	Homo sapiens	26-47
22697478-1	2012	The lectin-like domain of Tumor Necrosis Factor (TNF), mimicked by the TIP peptide, activates amiloride-sensitive sodium uptake in type II alveolar epithelial cells and as such increases alveolar liquid clearance in dysfunctional lungs.	Amiloride	94-103	tumor necrosis factor	Homo sapiens	49-52
22438887-6	2012	Amiloride enhanced development of full CD8 cytolytic function including induction of high levels of antigen specific CTL and expression of IFN-gamma+perforin+granzymeB+ in CD8+ T cells.	Amiloride	0-9	CD8a molecule	Homo sapiens	39-42
22438887-6	2012	Amiloride enhanced development of full CD8 cytolytic function including induction of high levels of antigen specific CTL and expression of IFN-gamma+perforin+granzymeB+ in CD8+ T cells.	Amiloride	0-9	interferon gamma	Homo sapiens	139-148
22438887-6	2012	Amiloride enhanced development of full CD8 cytolytic function including induction of high levels of antigen specific CTL and expression of IFN-gamma+perforin+granzymeB+ in CD8+ T cells.	Amiloride	0-9	CD8a molecule	Homo sapiens	172-175
22005681-6	2011	Tests of specificity of the two antagonists revealed that the low dose of amiloride and APETx2 greatly attenuated the pressor response to lactic acid, an ASIC agonist, but did not attenuate the pressor response to capsaicin, a TRPV1 agonist.	Amiloride	74-83	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	227-232
21900457-4	2011	Expressing FXYD5 in these cells leads to a large decrease in amiloride-insensitive transepithelial electrical resistance as well as increased permeability to 4-kDa dextran.	Amiloride	61-70	FXYD domain containing ion transport regulator 5	Homo sapiens	11-16
21978672-0	2011	Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA).	Amiloride	40-49	plasminogen activator, urokinase	Homo sapiens	79-115
21978672-0	2011	Synthesis and preliminary evaluation of amiloride analogs as inhibitors of the urokinase-type plasminogen activator (uPA).	Amiloride	40-49	plasminogen activator, urokinase	Homo sapiens	117-120
21978672-1	2011	A known side-activity of the oral potassium-sparing diuretic drug amiloride is inhibition of the enzyme urokinase-type plasminogen activator (uPA, K(i)=7 muM), a promising anticancer target.	Amiloride	66-75	plasminogen activator, urokinase	Homo sapiens	104-140
21978672-1	2011	A known side-activity of the oral potassium-sparing diuretic drug amiloride is inhibition of the enzyme urokinase-type plasminogen activator (uPA, K(i)=7 muM), a promising anticancer target.	Amiloride	66-75	plasminogen activator, urokinase	Homo sapiens	142-145
21978672-1	2011	A known side-activity of the oral potassium-sparing diuretic drug amiloride is inhibition of the enzyme urokinase-type plasminogen activator (uPA, K(i)=7 muM), a promising anticancer target.	Amiloride	66-75	latexin	Homo sapiens	154-157
21978672-2	2011	Several studies have demonstrated significant antitumor/metastasis properties for amiloride in animal cancer models and it would appear that these arise, at least in part, through inhibition of uPA.	Amiloride	82-91	plasminogen activator, urokinase	Homo sapiens	194-197
21978672-3	2011	Selective optimization of amiloride"s structure for more potent inhibition of uPA and loss of diuretic effects would thus appear as an attractive strategy towards novel anticancer agents.	Amiloride	26-35	plasminogen activator, urokinase	Homo sapiens	78-81
21978672-4	2011	The following report is a preliminary structure-activity exploration of amiloride analogs as inhibitors of uPA.	Amiloride	72-81	plasminogen activator, urokinase	Homo sapiens	107-110
21978672-5	2011	A key finding was that the well-studied 5-substituted analogs ethylisopropyl amiloride (EIPA) and hexamethylene amiloride (HMA) are approximately twofold more potent than amiloride as uPA inhibitors.	Amiloride	77-86	plasminogen activator, urokinase	Homo sapiens	184-187
22792205-11	2012	This stimulatory effect was abolished by blocking ASIC1 with a nonselective inhibitor (amiloride 10 mM), a selective inhibitor (PcTX1, 10 nM) or by damaging orexin neurons in the LH.	Amiloride	87-96	acid sensing ion channel subunit 1	Homo sapiens	50-55
21998313-0	2011	Nonproton ligand sensing domain is required for paradoxical stimulation of acid-sensing ion channel 3 (ASIC3) channels by amiloride.	Amiloride	122-131	acid sensing ion channel subunit 3	Homo sapiens	75-101
21998313-0	2011	Nonproton ligand sensing domain is required for paradoxical stimulation of acid-sensing ion channel 3 (ASIC3) channels by amiloride.	Amiloride	122-131	acid sensing ion channel subunit 3	Homo sapiens	103-108
21998313-2	2011	In this study, we reported that AMI paradoxically opened homomeric ASIC3 and heteromeric ASIC3 plus ASIC1b channels at neutral pH and synergistically enhanced channel activation induced by mild acidosis (pH 7.2 to 6.8).	Amiloride	32-35	acid sensing ion channel subunit 3	Homo sapiens	67-72
21998313-3	2011	The characteristic profile of AMI stimulation of ASIC3 channels was reminiscent of the channel activation by the newly identified nonproton ligand, 2-guanidine-4-methylquinazoline.	Amiloride	30-33	acid sensing ion channel subunit 3	Homo sapiens	49-54
21998313-4	2011	Using site-directed mutagenesis, we showed that ASIC3 activation by AMI, but not its inhibitory effect, was dependent on the integrity of the nonproton ligand sensing domain in ASIC3 channels.	Amiloride	68-71	acid sensing ion channel subunit 3	Homo sapiens	48-53
21998313-4	2011	Using site-directed mutagenesis, we showed that ASIC3 activation by AMI, but not its inhibitory effect, was dependent on the integrity of the nonproton ligand sensing domain in ASIC3 channels.	Amiloride	68-71	acid sensing ion channel subunit 3	Homo sapiens	177-182
21998313-6	2011	Furthermore, using covalent modification analyses, we provided strong evidence supporting the nonproton ligand sensing domain is required for the stimulation of ASIC3 channels by AMI.	Amiloride	179-182	acid sensing ion channel subunit 3	Homo sapiens	161-166
21998313-7	2011	Finally, we showed that AMI causes pain-related behaviors in an ASIC3-dependent manner.	Amiloride	24-27	acid sensing ion channel subunit 3	Homo sapiens	64-69
21911609-5	2011	In contrast, the non-selective ASIC and Na(+)-H(+) exchanger (NHE1) antagonists, amiloride and its analogues, suppressed nicotine-evoked responses in MHb neurones of wild-type and ASIC2 null mice, excluding a possible involvement of ASIC2 in the nAChR inhibition by amiloride.	Amiloride	81-90	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	62-66
21911609-5	2011	In contrast, the non-selective ASIC and Na(+)-H(+) exchanger (NHE1) antagonists, amiloride and its analogues, suppressed nicotine-evoked responses in MHb neurones of wild-type and ASIC2 null mice, excluding a possible involvement of ASIC2 in the nAChR inhibition by amiloride.	Amiloride	81-90	acid-sensing (proton-gated) ion channel 2	Mus musculus	180-185
21911609-5	2011	In contrast, the non-selective ASIC and Na(+)-H(+) exchanger (NHE1) antagonists, amiloride and its analogues, suppressed nicotine-evoked responses in MHb neurones of wild-type and ASIC2 null mice, excluding a possible involvement of ASIC2 in the nAChR inhibition by amiloride.	Amiloride	81-90	acid-sensing (proton-gated) ion channel 2	Mus musculus	233-238
21911609-5	2011	In contrast, the non-selective ASIC and Na(+)-H(+) exchanger (NHE1) antagonists, amiloride and its analogues, suppressed nicotine-evoked responses in MHb neurones of wild-type and ASIC2 null mice, excluding a possible involvement of ASIC2 in the nAChR inhibition by amiloride.	Amiloride	81-90	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	246-251
21911609-5	2011	In contrast, the non-selective ASIC and Na(+)-H(+) exchanger (NHE1) antagonists, amiloride and its analogues, suppressed nicotine-evoked responses in MHb neurones of wild-type and ASIC2 null mice, excluding a possible involvement of ASIC2 in the nAChR inhibition by amiloride.	Amiloride	266-275	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	62-66
21823219-11	2011	Annexin-V-binding was blunted by Ca(2+) removal, by the cation channel inhibitor amiloride (1 mM), by the protein kinase C inhibitor staurosporine (500 nM) but not by the pancaspase inhibitor zVAD (10 muM).	Amiloride	81-90	annexin A5	Homo sapiens	0-9
21782880-12	2011	In Jurkat cells incubated with amiloride (30 muM), the ACO-induced inhibition of I(K(DR)) remained unaltered.	Amiloride	31-40	latexin	Homo sapiens	45-48
21828194-6	2011	Application of millimolar concentrations of flufenamic acid to rBLINaC induced a robust, Na(+)-selective current, which was blocked partially by amiloride.	Amiloride	145-154	acid sensing ion channel subunit family member 5	Rattus norvegicus	63-70
21454253-3	2011	ENaC activity, assessed as whole cell amiloride-sensitive current in split-open tubules, was 260 +- 40 pA/cell in K-repleted but virtually undetectable (3 +- 1 pA/cell) in K-depleted animals.	Amiloride	38-47	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	0-4
21613418-6	2011	Inhibiting basolateral NHE1 with bath amiloride eliminated 60% of the adaptive increase in HCO(3)(-) absorption.	Amiloride	38-47	solute carrier family 9 member A1	Rattus norvegicus	23-27
21559843-0	2011	Alveolar epithelial CNGA1 channels mediate cGMP-stimulated, amiloride-insensitive, lung liquid absorption.	Amiloride	60-69	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	20-25
21559843-6	2011	Channel specificity of PsTx and amiloride was confirmed by patch clamp experiments showing that CNGA1 channels in HEK 293 cells were not inhibited by 100 muM amiloride and that recombinant alphabetagamma-ENaC were not inhibited by 100 nM PsTx.	Amiloride	32-41	cyclic nucleotide gated channel subunit alpha 1	Homo sapiens	96-101
21559843-9	2011	Thus, transport through alveolar CNGA1 channels, located in type I cells, underlies the amiloride-insensitive component of lung liquid reabsorption.	Amiloride	88-97	cyclic nucleotide gated channel subunit alpha 1	Rattus norvegicus	33-38
21356098-8	2011	The serum levels of TNF-alpha and NO were decreased 61% - 84% (P &lt; 0.001), and 14% - 67%, respectively, in chickens fed diets supplemented with delta-tocotrienol, quercetin, riboflavin, (-) Corey lactone, amiloride, or dexamethasone as compared to controls.	Amiloride	208-217	lipopolysaccharide induced TNF factor	Gallus gallus	20-29
21478252-3	2011	We hypothesized that double-stranded RNA/TLR-3 signaling underlies nucleotide-mediated inhibition of amiloride-sensitive AFC in both infections.	Amiloride	101-110	toll like receptor 3	Homo sapiens	41-46
21413028-8	2011	Sodium-dependent pHi recovery from weak acid loading was inhibited by amiloride with the Ki consistent with NHEs.	Amiloride	70-79	glucose-6-phosphate isomerase	Homo sapiens	17-20
21082215-1	2011	BIIB 513 and EMD 85131 are selective inhibitors of the Na+/H+ exchanger-1 (NHE-1) that are benzoylguanidine derivatives of the clinically employed diuretic amiloride.	Amiloride	156-165	solute carrier family 9 member A1	Canis lupus familiaris	55-73
21082215-1	2011	BIIB 513 and EMD 85131 are selective inhibitors of the Na+/H+ exchanger-1 (NHE-1) that are benzoylguanidine derivatives of the clinically employed diuretic amiloride.	Amiloride	156-165	solute carrier family 9 member A1	Canis lupus familiaris	75-80
21082215-2	2011	Prior studies have suggested a role for NHE-1 activity in platelet activation and aggregation using amiloride or its non- benzoylguanidines derivatives.	Amiloride	100-109	solute carrier family 9 member A1	Canis lupus familiaris	40-45
21106690-3	2011	In fungiform and vallate TRCs that exhibit functional ENaC currents (e.g., amiloride-sensitive Na(+) influx), insulin (5-20 nM) caused a significant increase in Na(+) influx at -80 mV (EC(50) = 7.53 nM).	Amiloride	75-84	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	54-58
21106690-3	2011	In fungiform and vallate TRCs that exhibit functional ENaC currents (e.g., amiloride-sensitive Na(+) influx), insulin (5-20 nM) caused a significant increase in Na(+) influx at -80 mV (EC(50) = 7.53 nM).	Amiloride	75-84	insulin	Homo sapiens	110-117
21106690-4	2011	The insulin-enhanced currents were inhibited by amiloride (30 muM).	Amiloride	48-57	insulin	Homo sapiens	4-11
21106690-9	2011	Interestingly, these differences between groups were abolished when amiloride (100 muM) was added into NaCl solutions, suggesting that insulin was regulating ENaC.	Amiloride	68-77	insulin	Homo sapiens	135-142
21106690-9	2011	Interestingly, these differences between groups were abolished when amiloride (100 muM) was added into NaCl solutions, suggesting that insulin was regulating ENaC.	Amiloride	68-77	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	158-162
21233458-0	2011	Antinatriuretic effect of vasopressin in humans is amiloride sensitive, thus ENaC dependent.	Amiloride	51-60	arginine vasopressin	Homo sapiens	26-37
21178974-7	2011	Around 30% of baseline and 50% of vasopressin-induced water flow is coupled to an amiloride-sensitive, ENaC-mediated, electrogenic sodium transport, whereas the remaining flow is coupled to an amiloride-insensitive, nonelectrogenic sodium transport mediated by an unknown electroneutral transporter.	Amiloride	82-91	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	103-107
21241666-0	2011	The dilated TRPA1 channel pore state is blocked by amiloride and analogues.	Amiloride	51-60	transient receptor potential cation channel subfamily A member 1	Homo sapiens	12-17
21575590-9	2011	The effects of oridonin on annexin V binding were partially reversed in the nominal absence of Ca(2+) and by the addition of amiloride (1mM).	Amiloride	125-134	annexin A5	Homo sapiens	27-36
21534729-4	2011	Rats receiving amiloride treatment also exhibited a significant increase in myelin oligodendrocyte glycoprotein (MOG) levels 35 days after SCI at the site of injury (T10) when compared to vehicle-treated controls, which indicated a partial reverse in the decrease of MOG observed with injury.	Amiloride	15-24	myelin oligodendrocyte glycoprotein	Rattus norvegicus	76-111
21534729-4	2011	Rats receiving amiloride treatment also exhibited a significant increase in myelin oligodendrocyte glycoprotein (MOG) levels 35 days after SCI at the site of injury (T10) when compared to vehicle-treated controls, which indicated a partial reverse in the decrease of MOG observed with injury.	Amiloride	15-24	myelin oligodendrocyte glycoprotein	Rattus norvegicus	113-116
21534729-4	2011	Rats receiving amiloride treatment also exhibited a significant increase in myelin oligodendrocyte glycoprotein (MOG) levels 35 days after SCI at the site of injury (T10) when compared to vehicle-treated controls, which indicated a partial reverse in the decrease of MOG observed with injury.	Amiloride	15-24	myelin oligodendrocyte glycoprotein	Rattus norvegicus	267-270
21534729-5	2011	Our data indicate that higher levels of MOG correlate with improved locomotor recovery after SCI, and that this may explain the beneficial effects of amiloride after SCI.	Amiloride	150-159	myelin oligodendrocyte glycoprotein	Rattus norvegicus	40-43
21470685-5	2011	In contrast, the transmigration was significantly inhibited by Fab" fragment of anti-uPAR monoclonal antibody and proteolytically inactive urokinase (uPA), whereas inhibition of proteolytical activity of endogenous uPA (with amiloride or plasminogen activator inhibitor-1) did not affect the transmigration.	Amiloride	225-234	FA complementation group B	Homo sapiens	63-66
21470685-5	2011	In contrast, the transmigration was significantly inhibited by Fab" fragment of anti-uPAR monoclonal antibody and proteolytically inactive urokinase (uPA), whereas inhibition of proteolytical activity of endogenous uPA (with amiloride or plasminogen activator inhibitor-1) did not affect the transmigration.	Amiloride	225-234	plasminogen activator, urokinase receptor	Homo sapiens	85-89
21470685-5	2011	In contrast, the transmigration was significantly inhibited by Fab" fragment of anti-uPAR monoclonal antibody and proteolytically inactive urokinase (uPA), whereas inhibition of proteolytical activity of endogenous uPA (with amiloride or plasminogen activator inhibitor-1) did not affect the transmigration.	Amiloride	225-234	plasminogen activator, urokinase	Homo sapiens	85-88
21470685-5	2011	In contrast, the transmigration was significantly inhibited by Fab" fragment of anti-uPAR monoclonal antibody and proteolytically inactive urokinase (uPA), whereas inhibition of proteolytical activity of endogenous uPA (with amiloride or plasminogen activator inhibitor-1) did not affect the transmigration.	Amiloride	225-234	plasminogen activator, urokinase	Homo sapiens	150-153
20151228-8	2011	Further experiment using amiloride (an inhibitor of NHE1) confirmed the above result.	Amiloride	25-34	solute carrier family 9 member A1	Homo sapiens	52-56
21300902-3	2011	These effects of Nedd4L loss are likely caused by enhanced ENaC function, as reflected by increased ENaC protein levels, increased lung dryness at birth, amiloride-sensitive dehydration of lung explants, and elevated ENaC currents in primary alveolar type II cells analyzed by patch clamp recordings.	Amiloride	154-163	NEDD4 like E3 ubiquitin protein ligase	Homo sapiens	17-23
21224352-2	2011	In this study, we show that amiloride modulates the alternative splicing of various cancer genes, including Bcl-x, HIPK3, and BCR/ABL, and that this effect is not mainly related to pH alteration, which is a known effect of the drug.	Amiloride	28-37	homeodomain interacting protein kinase 3	Homo sapiens	115-120
21233144-8	2011	Moreover, blocking acid-sensing ion channel 1 with amiloride protected both myelin and neurons from damage in the acute model, and when given either at disease onset or, more clinically relevant, at first relapse, ameliorated disability in mice with chronic-relapsing experimental autoimmune encephalomyelitis.	Amiloride	51-60	acid-sensing (proton-gated) ion channel 1	Mus musculus	19-45
21224352-0	2011	Amiloride modulates alternative splicing in leukemic cells and resensitizes Bcr-AblT315I mutant cells to imatinib.	Amiloride	0-9	BCR activator of RhoGEF and GTPase	Homo sapiens	76-79
21224352-2	2011	In this study, we show that amiloride modulates the alternative splicing of various cancer genes, including Bcl-x, HIPK3, and BCR/ABL, and that this effect is not mainly related to pH alteration, which is a known effect of the drug.	Amiloride	28-37	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	126-133
21224352-2	2011	In this study, we show that amiloride modulates the alternative splicing of various cancer genes, including Bcl-x, HIPK3, and BCR/ABL, and that this effect is not mainly related to pH alteration, which is a known effect of the drug.	Amiloride	28-37	BCL2 like 1	Homo sapiens	108-113
21224352-4	2011	Pretreatment with okadaic acid to inhibit protein phosphatase PP1 reversed partially the phosphorylation levels of SR proteins and also the amiloride-modulated yields of Bcl-xs and HIPK3 U(-) isoforms.	Amiloride	140-149	inorganic pyrophosphatase 1	Homo sapiens	62-65
21224352-4	2011	Pretreatment with okadaic acid to inhibit protein phosphatase PP1 reversed partially the phosphorylation levels of SR proteins and also the amiloride-modulated yields of Bcl-xs and HIPK3 U(-) isoforms.	Amiloride	140-149	homeodomain interacting protein kinase 3	Homo sapiens	181-186
21224352-5	2011	Genome-wide detection of alternative splicing further revealed that many other apoptotic genes were regulated by amiloride, including APAF-1, CRK, and SURVIVIN.	Amiloride	113-122	apoptotic peptidase activating factor 1	Homo sapiens	134-140
21224352-5	2011	Genome-wide detection of alternative splicing further revealed that many other apoptotic genes were regulated by amiloride, including APAF-1, CRK, and SURVIVIN.	Amiloride	113-122	CRK proto-oncogene, adaptor protein	Homo sapiens	142-145
21224352-6	2011	Various proteins of the Bcl-2 family and MAPK kinases were found to be involved in amiloride-induced apoptosis.	Amiloride	83-92	BCL2 apoptosis regulator	Homo sapiens	24-29
21224352-7	2011	Moreover, the effect of amiloride on mRNA levels of Bcl-x was demonstrated to translate to the protein levels.	Amiloride	24-33	BCL2 like 1	Homo sapiens	52-57
21036125-12	2011	Amiloride decreased the inflammatory response to hemorrhagic shock and resuscitation by lowering the levels of TNF.	Amiloride	0-9	tumor necrosis factor	Rattus norvegicus	111-114
21224352-8	2011	Cotreatment of K562 and BaF3/Bcr-AblT315I cells with amiloride and imatinib induced more loss of cell viability than either agent alone.	Amiloride	53-62	BCR activator of RhoGEF and GTPase	Homo sapiens	29-32
21865743-11	2011	The effects of benzethonium on annexin V binding were blunted in the nominal absence of Ca(2+) and in the presence of amiloride (1 mM) but not in the presence of the pancaspase inhibitor zVAD (10 muM).	Amiloride	118-127	annexin A5	Homo sapiens	31-40
20969731-10	2011	In CBG-(/)- mice this up-regulation was greatly attenuated as seen in a markedly reduced amiloride-sensitive short circuit current (reduced by ~50%), a reduced ability to lower faecal Na(+) excretion and a significantly attenuated up-regulation of the ENaC channel gamma-subunit.	Amiloride	89-98	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	3-6
20655126-5	2011	LPC-induced caspase-1 activity was almost completely inhibited upon omission of extracellular Na(+), but was unaffected by inhibition of Na(+)/K(+)-ATPase with ouabain or by inhibition of Na(+)/H(+) antiport with amiloride.	Amiloride	213-222	caspase 1	Homo sapiens	12-21
20930109-8	2011	Inhibition of macropinocytosis with either amiloride or wortmannin blocked the increase in macropinocytosis mediated by CTR2 knockdown.	Amiloride	43-52	solute carrier family 31 member 2	Homo sapiens	120-124
20971560-8	2011	Amiloride, a non-specific blocker of ASIC channels, inhibited the peak currents evoked upon application of decreased pH while no inhibition was observed upon application of TRPV1 antagonists.	Amiloride	0-9	acid sensing ion channel subunit 1	Homo sapiens	37-41
20971560-10	2011	Finally, application of pH 5.0 synthetic-interstitial fluid to the dura produced significant decreases in facial and hind-paw withdrawal threshold, an effect blocked by amiloride but not TRPV1 antagonists, suggesting that ASIC activation produces migraine-related behavior in vivo.	Amiloride	169-178	acid sensing ion channel subunit 1	Homo sapiens	222-226
21832840-6	2011	In the presence of a pH(i) clamp, pH(i)/extracellular pH (pH(o)) 7.1/7.4, insulin increased amiloride-sensitive (22)Na uptake by 98 +- 25% (p &lt; 0.05).	Amiloride	92-101	insulin	Canis lupus familiaris	74-81
21832840-7	2011	At pH(i)/pH(o) 6.0/7.4 or 6.7/7.4, amiloride-sensitive (22)Na uptake was stimulated by 378 +- 59 and 105 +- 27%, respectively, compared to pH(i)/pH(o) 7.1/7.4 (p &lt; 0.05 for all 3 versus each other), but was insulin insensitive.	Amiloride	35-44	insulin	Canis lupus familiaris	210-217
22216333-7	2011	(125)I-CXCL1 endocytosis was inhibited by amiloride, cytochalasin D, and the PKC inhibitor Go6976 whereas Platelet Derived Growth Factor (PDGF) enhanced ligand internalization through DARC.	Amiloride	42-51	C-X-C motif chemokine ligand 1	Homo sapiens	7-12
21887217-5	2011	In the HEPES buffered Krebs-Henseleit (KH) solution, the intracellular pH (pHi) recovery from NH(4)Cl induced acidification in the cultured caput epididymal epithelium was completely inhibited by amiloride, the inhibitor of Na(+)/H(+) exchanger (NHE).	Amiloride	196-205	glucose-6-phosphate isomerase	Rattus norvegicus	71-73
21887217-5	2011	In the HEPES buffered Krebs-Henseleit (KH) solution, the intracellular pH (pHi) recovery from NH(4)Cl induced acidification in the cultured caput epididymal epithelium was completely inhibited by amiloride, the inhibitor of Na(+)/H(+) exchanger (NHE).	Amiloride	196-205	glucose-6-phosphate isomerase	Rattus norvegicus	75-78
21145458-8	2010	Like human CF, CFTR-(/)- pigs showed increased amiloride-sensitive voltage and current, but lack of apical Cl- conductance caused the change, not increased Na(+) transport.	Amiloride	47-56	CF transmembrane conductance regulator	Homo sapiens	15-19
21694768-3	2011	Screening small molecules and drugs for modulating RNA splicing in human hepatocellular carcinoma cell line Huh-7, we discovered that amiloride, distinct from four pH-affecting amiloride analogues, could "normalize" the splicing of BCL-X, HIPK3 and RON/MISTR1 transcripts.	Amiloride	134-143	BCL2 like 1	Homo sapiens	232-237
21694768-3	2011	Screening small molecules and drugs for modulating RNA splicing in human hepatocellular carcinoma cell line Huh-7, we discovered that amiloride, distinct from four pH-affecting amiloride analogues, could "normalize" the splicing of BCL-X, HIPK3 and RON/MISTR1 transcripts.	Amiloride	134-143	homeodomain interacting protein kinase 3	Homo sapiens	239-244
21694768-3	2011	Screening small molecules and drugs for modulating RNA splicing in human hepatocellular carcinoma cell line Huh-7, we discovered that amiloride, distinct from four pH-affecting amiloride analogues, could "normalize" the splicing of BCL-X, HIPK3 and RON/MISTR1 transcripts.	Amiloride	134-143	macrophage stimulating 1 receptor	Homo sapiens	249-252
21694768-4	2011	Our proteomic analyses of amiloride-treated cells detected hypo-phosphorylation of splicing factor SF2/ASF, and decreased levels of SRp20 and two un-identified SR proteins.	Amiloride	26-35	serine and arginine rich splicing factor 1	Homo sapiens	99-102
21694768-4	2011	Our proteomic analyses of amiloride-treated cells detected hypo-phosphorylation of splicing factor SF2/ASF, and decreased levels of SRp20 and two un-identified SR proteins.	Amiloride	26-35	serine and arginine rich splicing factor 1	Homo sapiens	103-106
21694768-4	2011	Our proteomic analyses of amiloride-treated cells detected hypo-phosphorylation of splicing factor SF2/ASF, and decreased levels of SRp20 and two un-identified SR proteins.	Amiloride	26-35	serine and arginine rich splicing factor 3	Homo sapiens	132-137
21694768-5	2011	We further observed decreased phosphorylation of AKT, ERK1/2 and PP1, and increased phosphorylation of p38 and JNK, suggesting that amiloride treatment down-regulates kinases and up-regulates phosphatases in the signal pathways known to affect splicing factor protein phosphorylation.	Amiloride	132-141	AKT serine/threonine kinase 1	Homo sapiens	49-52
21694768-5	2011	We further observed decreased phosphorylation of AKT, ERK1/2 and PP1, and increased phosphorylation of p38 and JNK, suggesting that amiloride treatment down-regulates kinases and up-regulates phosphatases in the signal pathways known to affect splicing factor protein phosphorylation.	Amiloride	132-141	mitogen-activated protein kinase 3	Homo sapiens	54-60
21694768-5	2011	We further observed decreased phosphorylation of AKT, ERK1/2 and PP1, and increased phosphorylation of p38 and JNK, suggesting that amiloride treatment down-regulates kinases and up-regulates phosphatases in the signal pathways known to affect splicing factor protein phosphorylation.	Amiloride	132-141	inorganic pyrophosphatase 1	Homo sapiens	65-68
21694768-5	2011	We further observed decreased phosphorylation of AKT, ERK1/2 and PP1, and increased phosphorylation of p38 and JNK, suggesting that amiloride treatment down-regulates kinases and up-regulates phosphatases in the signal pathways known to affect splicing factor protein phosphorylation.	Amiloride	132-141	mitogen-activated protein kinase 1	Homo sapiens	103-106
21694768-5	2011	We further observed decreased phosphorylation of AKT, ERK1/2 and PP1, and increased phosphorylation of p38 and JNK, suggesting that amiloride treatment down-regulates kinases and up-regulates phosphatases in the signal pathways known to affect splicing factor protein phosphorylation.	Amiloride	132-141	mitogen-activated protein kinase 8	Homo sapiens	111-114
22332421-11	2011	Dominant negative dynamin K44A transfected into CHO cells together with ENaC subunits significantly increased amiloride-sensitive current density compared to cells transfected with ENaC subunits only (control); additional transfection of cortactin in this system resulted in current density restitution back to the control level.	Amiloride	110-119	dynamin-2	Cricetulus griseus	18-25
22332421-11	2011	Dominant negative dynamin K44A transfected into CHO cells together with ENaC subunits significantly increased amiloride-sensitive current density compared to cells transfected with ENaC subunits only (control); additional transfection of cortactin in this system resulted in current density restitution back to the control level.	Amiloride	110-119	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	72-76
20979368-0	2010	Essential structural features of TNF-alpha lectin-like domain derived peptides for activation of amiloride-sensitive sodium current in A549 cells.	Amiloride	97-106	tumor necrosis factor	Homo sapiens	33-42
20869350-3	2010	While amiloride reduces pH(i) of malignant gliomas by inhibiting isoform 1 of sodium-proton exchange (NHE1), direct acidification was shown to be cytostatic rather than cytotoxic.	Amiloride	6-15	solute carrier family 9 member A1	Homo sapiens	102-106
20869350-4	2010	At cytotoxic concentrations, amiloride has multiple drug targets including inhibition of NHE1 and sodium-calcium exchange.	Amiloride	29-38	solute carrier family 9 member A1	Homo sapiens	89-93
20869350-5	2010	Amiloride"s glioma cytotoxicity can be explained, at least in part, by dual inhibition of NHE1 and of Na(+)-dependent calcium efflux by isoform 1.1 of the sodium-calcium exchanger (NCX1.1), which increases [Ca(2+)](i) and initiates glioma cell demise.	Amiloride	0-9	solute carrier family 9 member A1	Homo sapiens	90-94
20869350-5	2010	Amiloride"s glioma cytotoxicity can be explained, at least in part, by dual inhibition of NHE1 and of Na(+)-dependent calcium efflux by isoform 1.1 of the sodium-calcium exchanger (NCX1.1), which increases [Ca(2+)](i) and initiates glioma cell demise.	Amiloride	0-9	solute carrier family 8 member A1	Homo sapiens	181-185
20729267-9	2010	Compared with CFTR(+/+) thyroid cultures, amiloride-sensitive Na(+) absorption measured in CFTR(-/-) pThECs represented a greater fraction of the resting I(sc).	Amiloride	42-51	CF transmembrane conductance regulator	Sus scrofa	91-95
20979368-2	2010	The lectin-like domain of TNF-alpha has been shown to activate amiloride-sensitive sodium uptake in type II alveolar epithelial cells.	Amiloride	63-72	tumor necrosis factor	Homo sapiens	26-35
20454829-10	2010	COII and aggrecan mRNA and protein expression in the articular cartilage was significantly increased by amiloride.	Amiloride	104-113	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	0-4
20683339-0	2010	Amiloride lowers arterial pressure in cyp1a1ren-2 transgenic rats without affecting renal vascular function.	Amiloride	0-9	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	38-49
20683339-13	2010	Amiloride treatment caused an increase in alpha-ENaC mRNA abundance in renal cortical tissue but not in intrarenal arteries.	Amiloride	0-9	sodium channel epithelial 1 subunit alpha	Rattus norvegicus	42-52
20683339-14	2010	CONCLUSION: Amiloride reduces arterial pressure in cyp1a1ren-2 transgenic rats in association with increased renal sodium excretion without affecting renal vascular function.	Amiloride	12-21	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	51-62
20656685-8	2010	In addition, mBLINaC is more selective for Na(+) and has a 700-fold higher amiloride affinity than rBLINaC.	Amiloride	75-84	acid-sensing (proton-gated) ion channel family member 5	Mus musculus	13-20
20631247-7	2010	Coexpression of deltabetagamma-ENaC and SGK1.1 in Xenopus oocytes increases amiloride-sensitive current and channel plasma membrane abundance.	Amiloride	76-85	serum/glucocorticoid regulated kinase 1	Homo sapiens	40-44
20656685-4	2010	Expression of rat BLINaC (rBLINaC) in Xenopus oocytes leads to small unselective currents that are only weakly sensitive to amiloride.	Amiloride	124-133	acid sensing ion channel subunit family member 5	Rattus norvegicus	18-24
20434520-4	2010	Apical membrane insertion of ENaCbeta in response to aldosterone treatment was also sensitive to PKD1 suppression as was the aldosterone-induced rise in the amiloride-sensitive, trans-epithelial current (I(TE)).	Amiloride	157-166	sodium channel epithelial 1 subunit beta	Homo sapiens	29-37
20656685-4	2010	Expression of rat BLINaC (rBLINaC) in Xenopus oocytes leads to small unselective currents that are only weakly sensitive to amiloride.	Amiloride	124-133	acid sensing ion channel subunit family member 5	Rattus norvegicus	26-33
20592240-12	2010	Amiloride inhibited MA/MA+-induced current and the increase in pH(i) in oocytes expressing Rhbg but had no effect on control oocytes.	Amiloride	0-9	Rh family B glycoprotein	Homo sapiens	91-95
20594946-11	2010	Amiloride and its analogs benzamil and 5-N-ethyl-N-isopropylamiloride inhibited K-ATPase activity of HKalpha1-containing H,K-ATPase; the dose dependence of inhibition was similar for all three inhibitors.	Amiloride	0-9	ATPase, H+/K+ exchanging, beta polypeptide	Mus musculus	121-131
20594946-14	2010	Interestingly, pharmacological studies suggested that the mouse gastric H,K-ATPase is sensitive to amiloride.	Amiloride	99-108	ATPase, H+/K+ exchanging, beta polypeptide	Mus musculus	72-82
20651838-13	2010	Amiloride, an inhibitor of NHE-1, can limit the development of vessel stenosis through inhibition of VSM cell proliferation, migration, and excretion of ECMs.	Amiloride	0-9	sodium/hydrogen exchanger 1	Oryctolagus cuniculus	27-32
20493823-8	2010	Our analysis of a cell line expressing hT1R3 mutants (hT1R3-A733V or hT1R3-F778A) made us to conclude that the target site of amiloride is distinct from that of lactisole, a known sweet taste inhibitor.	Amiloride	126-135	taste 1 receptor member 3	Homo sapiens	39-44
20651838-1	2010	This study was designed to explore the effects of amiloride, a Na+-H+ exchange (NHE) inhibitor, on vessel stenosis by observing the expression of NHE-1 protein in vascular smooth muscle (VSM) after balloon injury and the effects of amiloride on VSM cell proliferation, migration, and excretion of extracellular matrices (ECMs).	Amiloride	50-59	sodium/hydrogen exchanger 1	Oryctolagus cuniculus	146-151
20740360-5	2010	Here, we show that treating Xenopus laevis oocytes expressing ENaC and PPARgamma with the TZD rosiglitazone (RGZ) produced a twofold increase of amiloride-sensitive sodium current (Iam), as measured by two-electrode voltage clamp.	Amiloride	145-154	peroxisome proliferator activated receptor gamma L homeolog	Xenopus laevis	71-80
20493823-8	2010	Our analysis of a cell line expressing hT1R3 mutants (hT1R3-A733V or hT1R3-F778A) made us to conclude that the target site of amiloride is distinct from that of lactisole, a known sweet taste inhibitor.	Amiloride	126-135	taste 1 receptor member 3	Homo sapiens	54-59
20493823-8	2010	Our analysis of a cell line expressing hT1R3 mutants (hT1R3-A733V or hT1R3-F778A) made us to conclude that the target site of amiloride is distinct from that of lactisole, a known sweet taste inhibitor.	Amiloride	126-135	taste 1 receptor member 3	Homo sapiens	54-59
20180817-9	2010	Blocking u-PA activity with the active site-directed protease inhibitor amiloride substantially decreased MCF-10CA1 cell motility.	Amiloride	72-81	plasminogen activator, urokinase	Homo sapiens	9-13
20590595-11	2010	Pretreatment with the ENaC blockers, amiloride or 552-02, resulted in an enhancement of HS-induced lung fluid signals, which were detectable for up to 4 h, consistent with a role for ENaC in fluid clearance.	Amiloride	37-46	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	22-26
20590595-11	2010	Pretreatment with the ENaC blockers, amiloride or 552-02, resulted in an enhancement of HS-induced lung fluid signals, which were detectable for up to 4 h, consistent with a role for ENaC in fluid clearance.	Amiloride	37-46	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	183-187
20237237-2	2010	Our previous studies demonstrated that Copper Metabolism Murr1 Domain-containing protein 1 (COMMD1; previously known as Murr1), a protein involved in copper metabolism, inhibited amiloride-sensitive current in Xenopus laevis oocytes expressing ENaC (J Biol Chem 279: 5429, 2004).	Amiloride	179-188	copper metabolism domain containing 1 L homeolog	Xenopus laevis	39-90
20237237-2	2010	Our previous studies demonstrated that Copper Metabolism Murr1 Domain-containing protein 1 (COMMD1; previously known as Murr1), a protein involved in copper metabolism, inhibited amiloride-sensitive current in Xenopus laevis oocytes expressing ENaC (J Biol Chem 279: 5429, 2004).	Amiloride	179-188	copper metabolism domain containing 1 L homeolog	Xenopus laevis	92-98
20237237-2	2010	Our previous studies demonstrated that Copper Metabolism Murr1 Domain-containing protein 1 (COMMD1; previously known as Murr1), a protein involved in copper metabolism, inhibited amiloride-sensitive current in Xenopus laevis oocytes expressing ENaC (J Biol Chem 279: 5429, 2004).	Amiloride	179-188	copper metabolism domain containing 1 L homeolog	Xenopus laevis	57-62
20237237-2	2010	Our previous studies demonstrated that Copper Metabolism Murr1 Domain-containing protein 1 (COMMD1; previously known as Murr1), a protein involved in copper metabolism, inhibited amiloride-sensitive current in Xenopus laevis oocytes expressing ENaC (J Biol Chem 279: 5429, 2004).	Amiloride	179-188	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	244-248
20237237-3	2010	In this study, we report that COMMD1 inhibits amiloride-sensitive current in mammalian epithelial cells expressing ENaC, that the COMM domain of COMMD1 is sufficient for this effect, and that knockdown of COMMD1 increases amiloride-sensitive current.	Amiloride	46-55	copper metabolism domain containing 1	Homo sapiens	30-36
20237237-3	2010	In this study, we report that COMMD1 inhibits amiloride-sensitive current in mammalian epithelial cells expressing ENaC, that the COMM domain of COMMD1 is sufficient for this effect, and that knockdown of COMMD1 increases amiloride-sensitive current.	Amiloride	46-55	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	115-119
20237237-3	2010	In this study, we report that COMMD1 inhibits amiloride-sensitive current in mammalian epithelial cells expressing ENaC, that the COMM domain of COMMD1 is sufficient for this effect, and that knockdown of COMMD1 increases amiloride-sensitive current.	Amiloride	46-55	copper metabolism domain containing 1	Homo sapiens	145-151
20237237-3	2010	In this study, we report that COMMD1 inhibits amiloride-sensitive current in mammalian epithelial cells expressing ENaC, that the COMM domain of COMMD1 is sufficient for this effect, and that knockdown of COMMD1 increases amiloride-sensitive current.	Amiloride	46-55	copper metabolism domain containing 1	Homo sapiens	145-151
20237237-3	2010	In this study, we report that COMMD1 inhibits amiloride-sensitive current in mammalian epithelial cells expressing ENaC, that the COMM domain of COMMD1 is sufficient for this effect, and that knockdown of COMMD1 increases amiloride-sensitive current.	Amiloride	222-231	copper metabolism domain containing 1	Homo sapiens	30-36
20237237-3	2010	In this study, we report that COMMD1 inhibits amiloride-sensitive current in mammalian epithelial cells expressing ENaC, that the COMM domain of COMMD1 is sufficient for this effect, and that knockdown of COMMD1 increases amiloride-sensitive current.	Amiloride	222-231	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	115-119
20237237-3	2010	In this study, we report that COMMD1 inhibits amiloride-sensitive current in mammalian epithelial cells expressing ENaC, that the COMM domain of COMMD1 is sufficient for this effect, and that knockdown of COMMD1 increases amiloride-sensitive current.	Amiloride	222-231	copper metabolism domain containing 1	Homo sapiens	145-151
20237237-3	2010	In this study, we report that COMMD1 inhibits amiloride-sensitive current in mammalian epithelial cells expressing ENaC, that the COMM domain of COMMD1 is sufficient for this effect, and that knockdown of COMMD1 increases amiloride-sensitive current.	Amiloride	222-231	copper metabolism domain containing 1	Homo sapiens	145-151
20237237-6	2010	COMMD1 abolished insulin-stimulated amiloride-sensitive current and attenuated the stimulation of current by activated serum and glucocorticoid-regulated kinase (SGK1).	Amiloride	36-45	copper metabolism domain containing 1	Homo sapiens	0-6
20237237-6	2010	COMMD1 abolished insulin-stimulated amiloride-sensitive current and attenuated the stimulation of current by activated serum and glucocorticoid-regulated kinase (SGK1).	Amiloride	36-45	insulin	Homo sapiens	17-24
20237237-7	2010	COMMD1 was found to interact with both SGK1 and Akt1/protein kinase B, and knockdown of COMMD1 enhanced the stimulatory effect of both SGK1 and Akt1 on amiloride-sensitive current.	Amiloride	152-161	copper metabolism domain containing 1	Homo sapiens	0-6
20237237-7	2010	COMMD1 was found to interact with both SGK1 and Akt1/protein kinase B, and knockdown of COMMD1 enhanced the stimulatory effect of both SGK1 and Akt1 on amiloride-sensitive current.	Amiloride	152-161	serum/glucocorticoid regulated kinase 1	Homo sapiens	39-43
20237237-7	2010	COMMD1 was found to interact with both SGK1 and Akt1/protein kinase B, and knockdown of COMMD1 enhanced the stimulatory effect of both SGK1 and Akt1 on amiloride-sensitive current.	Amiloride	152-161	AKT serine/threonine kinase 1	Homo sapiens	48-52
20237237-7	2010	COMMD1 was found to interact with both SGK1 and Akt1/protein kinase B, and knockdown of COMMD1 enhanced the stimulatory effect of both SGK1 and Akt1 on amiloride-sensitive current.	Amiloride	152-161	protein tyrosine kinase 2 beta	Homo sapiens	53-69
20237237-7	2010	COMMD1 was found to interact with both SGK1 and Akt1/protein kinase B, and knockdown of COMMD1 enhanced the stimulatory effect of both SGK1 and Akt1 on amiloride-sensitive current.	Amiloride	152-161	copper metabolism domain containing 1	Homo sapiens	88-94
20237237-7	2010	COMMD1 was found to interact with both SGK1 and Akt1/protein kinase B, and knockdown of COMMD1 enhanced the stimulatory effect of both SGK1 and Akt1 on amiloride-sensitive current.	Amiloride	152-161	serum/glucocorticoid regulated kinase 1	Homo sapiens	135-139
20237237-7	2010	COMMD1 was found to interact with both SGK1 and Akt1/protein kinase B, and knockdown of COMMD1 enhanced the stimulatory effect of both SGK1 and Akt1 on amiloride-sensitive current.	Amiloride	152-161	AKT serine/threonine kinase 1	Homo sapiens	144-148
20551467-16	2010	In livers of amiloride-treated animals, the phosphorylation state of moesin and the number of alpha-SMA positive cells were reduced.	Amiloride	13-22	moesin	Rattus norvegicus	69-75
20551467-16	2010	In livers of amiloride-treated animals, the phosphorylation state of moesin and the number of alpha-SMA positive cells were reduced.	Amiloride	13-22	actin gamma 2, smooth muscle	Rattus norvegicus	94-103
20226807-7	2010	MAA and ACZ induced a concentration-dependent inhibition of ES-D3 cell differentiation, which was enhanced by amiloride, an inhibitor of the Na(+)/H(+)-antiporter, corroborating an important role of the pH(i) in the embryotoxic mechanism of both compounds.	Amiloride	110-119	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	141-162
20307259-8	2010	Inhibition of ascorbate-stimulated tPMET by the NHE (Na(+)/H(+)-exchanger) inhibitors amiloride and 5-(N-ethyl-N-isopropyl)amiloride, which is diminished by bicarbonate, suggests that tPMET activity may be regulated by intracellular pH.	Amiloride	86-95	solute carrier family 9 member C1	Homo sapiens	48-51
20307259-8	2010	Inhibition of ascorbate-stimulated tPMET by the NHE (Na(+)/H(+)-exchanger) inhibitors amiloride and 5-(N-ethyl-N-isopropyl)amiloride, which is diminished by bicarbonate, suggests that tPMET activity may be regulated by intracellular pH.	Amiloride	86-95	solute carrier family 9 member C1	Homo sapiens	53-73
20445050-4	2010	Deletion of the gene that encodes the amiloride-sensitive PPK28 channel, a DEG/eNaC (degenerin/epithelial sodium channel) family member, abolished the water-induced activity of water gustatory receptor neurons and greatly diminished the behavioral response of flies to water.	Amiloride	38-47	pickpocket 28	Drosophila melanogaster	58-63
21532778-7	2010	If the renin and aldosterone are both low the problem is over-activity of renal sodium channels and the treatment is amiloride.	Amiloride	117-126	renin	Homo sapiens	7-12
19856254-7	2010	RESULTS: Insulin increased Trans-mesothelial Resistance within 1st minute when added mesothelially of visceral (p=0.008) and parietal pleura (p=0.046) for concentrations higher than 10 (-7) M. L-NAME or Nitroprussid sodium didn"t but amiloride and ouabain inhibited insulin"s effect.	Amiloride	234-243	LOC105613195	Ovis aries	9-16
20214882-4	2010	Furthermore, cellular uptake was inhibited by amiloride, while no significant inhibitory effect was observed by the presence of chlorpromazine and filipin III, suggesting that macropinocytosis largely contributed to the cellular uptake of Lep(70-89)-PEG-LPs.	Amiloride	46-55	leptin	Mus musculus	239-242
20162507-10	2010	Since amiloride and ouabain abolish these electrochemical changes, it may be suggested that insulin could influence the pleural fluid recycling, mainly via the Na (+) transportation system, irrespective of the glucose content.	Amiloride	6-15	LOC105613195	Ovis aries	92-99
20048170-0	2010	Amiloride docking to acid-sensing ion channel-1.	Amiloride	0-9	acid sensing ion channel subunit 1	Homo sapiens	21-47
19520916-4	2010	When co-expressed with beta and gamma accessory subunits in heterologous systems, the two known isoforms of the delta-ENaC subunit (delta1 and delta2) can build amiloride-sensitive Na+ channels.	Amiloride	161-170	delta like non-canonical Notch ligand 1	Homo sapiens	112-149
20048170-4	2010	This work examines the interaction of amiloride with acid-sensing ion channel-1, a protein whose structure is available using computational and experimental techniques.	Amiloride	38-47	acid sensing ion channel subunit 1	Homo sapiens	53-79
20048170-5	2010	Using molecular docking software, amiloride and related molecules were docked to model structures of homomeric human ASIC-1 to generate potential interaction sites and predict which analogs would be more or less potent than amiloride.	Amiloride	34-43	acid sensing ion channel subunit 1	Homo sapiens	117-123
20048170-5	2010	Using molecular docking software, amiloride and related molecules were docked to model structures of homomeric human ASIC-1 to generate potential interaction sites and predict which analogs would be more or less potent than amiloride.	Amiloride	224-233	acid sensing ion channel subunit 1	Homo sapiens	117-123
20048170-10	2010	Using the aggregated data from these computational and experimental experiments, putative interaction sites for amiloride and hASIC-1 have been defined.	Amiloride	112-121	acid sensing ion channel subunit 1	Homo sapiens	126-133
20043279-5	2010	Sodium-driven alveolar fluid clearance (AFC) was reduced in CAP1/Prss8-deficient mice, due to a 48% decrease in amiloride-sensitive clearance, and was less sensitive to beta(2)-agonist treatment.	Amiloride	112-121	CAP, adenylate cyclase-associated protein 1 (yeast)	Mus musculus	60-64
20015086-6	2010	KEY RESULTS: Amiloride completely inhibited ER stress-induced activation of IRE1alpha, an ER-localized stress sensor protein, splicing of XBP1, and subsequent expression of GRP78 at the mRNA and protein levels.	Amiloride	13-22	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	76-85
20015086-6	2010	KEY RESULTS: Amiloride completely inhibited ER stress-induced activation of IRE1alpha, an ER-localized stress sensor protein, splicing of XBP1, and subsequent expression of GRP78 at the mRNA and protein levels.	Amiloride	13-22	X-box binding protein 1	Mus musculus	138-142
20015086-6	2010	KEY RESULTS: Amiloride completely inhibited ER stress-induced activation of IRE1alpha, an ER-localized stress sensor protein, splicing of XBP1, and subsequent expression of GRP78 at the mRNA and protein levels.	Amiloride	13-22	heat shock protein 5	Mus musculus	173-178
20156964-0	2010	Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling.	Amiloride	0-9	Rac family small GTPase 1	Homo sapiens	80-84
20156964-0	2010	Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling.	Amiloride	0-9	cell division cycle 42	Homo sapiens	89-94
19823867-2	2010	In human H441 airway epithelial cells, incubation of cells with 15 microg ml(-1) LPS caused a significant reduction in amiloride-sensitive I (sc) from 15 +/- 2 to 8 +/- 2 microA cm(-2) (p = 0.01, n = 13) and a shift in IC(50) amiloride of currents from 6.8 x 10(-7) to 6.4 x 10(-6) M. This effect was associated with a decrease in the activity of 5 pS, highly Na(+) selective, amiloride-sensitive &lt;1 microM channels (HSC) and an increase in the activity of approximately 18 pS, nonselective, amiloride-sensitive &gt;10 microM cation channels (NSC) in the apical membrane.	Amiloride	119-128	fucosyltransferase 1 (H blood group)	Homo sapiens	420-423
20015086-8	2010	Surprisingly, treatment with amiloride alone markedly promoted the phosphorylation but actually inhibited ER stress-induced CHOP expression.	Amiloride	29-38	DNA-damage inducible transcript 3	Mus musculus	124-128
19509473-5	2009	The experiments showed that aldosterone (10(-8) M) enhances the protein expression of p22phox and that its effect is reversed by co-incubation with canrenone (10(-6) M), while incubation with amiloride (10(-6) M) reduced the prooxidative effect of aldosterone at a significantly lower extent than canrenone.	Amiloride	192-201	cytochrome b-245 alpha chain	Homo sapiens	86-93
20016101-4	2009	The direction and pharmacology of transepithelial current was consistent with Na(+) absorption by the epithelial Na(+) channel (ENaC) and was blocked by the ENaC-specific inhibitors benzamil and amiloride.	Amiloride	195-204	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	102-126
20016101-4	2009	The direction and pharmacology of transepithelial current was consistent with Na(+) absorption by the epithelial Na(+) channel (ENaC) and was blocked by the ENaC-specific inhibitors benzamil and amiloride.	Amiloride	195-204	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	128-132
20016101-4	2009	The direction and pharmacology of transepithelial current was consistent with Na(+) absorption by the epithelial Na(+) channel (ENaC) and was blocked by the ENaC-specific inhibitors benzamil and amiloride.	Amiloride	195-204	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	157-161
19860742-10	2009	The ASIC channel antagonists gadolinium (0.1 mM) and amiloride (0.3 microM) reduced (P &lt; 0.05) the acid-evoked (pH 6.5) release to 40 and 6.5% respectively.	Amiloride	53-62	acid sensing ion channel subunit 1	Rattus norvegicus	4-8
19509473-9	2009	The addition of aldosterone-receptor antagonist canrenone produced a higher inhibition than sodium channel blocker amiloride on the effect of aldosterone on p22phox protein expression.	Amiloride	115-124	cytochrome b-245 alpha chain	Homo sapiens	157-164
19692481-7	2009	The TRPV1 antagonist capsazepine inhibited sustained, amiloride-transient currents.	Amiloride	54-63	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
20092750-6	2009	Immunocytochemistry staining showed CEA, CK8, CK18, CK19 was positive in sweat gland duct cells, RT-PCR revealed that CEA, CK8, CK18 and CK19 gene expression in sweat gland ductal cells, and Western Blot analysis showed the expression of CEA brand, CK8 brand, CK18 brand, and CK19 brand in sweat gland ductal cells, patch clamp indicated that this cells has distinct amiloride sensitive Na(+) channels.	Amiloride	367-376	keratin 19	Homo sapiens	137-141
19710385-7	2009	In NTS neurons, amiloride blocked over 80% of the recovery, which was also blocked approximately 65% by inhibitors of NHE-1 and 26% blocked by an inhibitor of NHE-3.	Amiloride	16-25	solute carrier family 9 member A1	Rattus norvegicus	118-123
19710385-7	2009	In NTS neurons, amiloride blocked over 80% of the recovery, which was also blocked approximately 65% by inhibitors of NHE-1 and 26% blocked by an inhibitor of NHE-3.	Amiloride	16-25	solute carrier family 9 member A3	Rattus norvegicus	159-164
20092750-6	2009	Immunocytochemistry staining showed CEA, CK8, CK18, CK19 was positive in sweat gland duct cells, RT-PCR revealed that CEA, CK8, CK18 and CK19 gene expression in sweat gland ductal cells, and Western Blot analysis showed the expression of CEA brand, CK8 brand, CK18 brand, and CK19 brand in sweat gland ductal cells, patch clamp indicated that this cells has distinct amiloride sensitive Na(+) channels.	Amiloride	367-376	CEA cell adhesion molecule 3	Homo sapiens	118-121
19710385-5	2009	Recovery in RTN neurons was nearly entirely eliminated by amiloride, an inhibitor of Na(+)/H(+) exchange (NHE).	Amiloride	58-67	solute carrier family 9 member A1	Rattus norvegicus	106-109
20092750-6	2009	Immunocytochemistry staining showed CEA, CK8, CK18, CK19 was positive in sweat gland duct cells, RT-PCR revealed that CEA, CK8, CK18 and CK19 gene expression in sweat gland ductal cells, and Western Blot analysis showed the expression of CEA brand, CK8 brand, CK18 brand, and CK19 brand in sweat gland ductal cells, patch clamp indicated that this cells has distinct amiloride sensitive Na(+) channels.	Amiloride	367-376	CEA cell adhesion molecule 3	Homo sapiens	118-121
20092750-6	2009	Immunocytochemistry staining showed CEA, CK8, CK18, CK19 was positive in sweat gland duct cells, RT-PCR revealed that CEA, CK8, CK18 and CK19 gene expression in sweat gland ductal cells, and Western Blot analysis showed the expression of CEA brand, CK8 brand, CK18 brand, and CK19 brand in sweat gland ductal cells, patch clamp indicated that this cells has distinct amiloride sensitive Na(+) channels.	Amiloride	367-376	keratin 18	Homo sapiens	128-132
20092750-6	2009	Immunocytochemistry staining showed CEA, CK8, CK18, CK19 was positive in sweat gland duct cells, RT-PCR revealed that CEA, CK8, CK18 and CK19 gene expression in sweat gland ductal cells, and Western Blot analysis showed the expression of CEA brand, CK8 brand, CK18 brand, and CK19 brand in sweat gland ductal cells, patch clamp indicated that this cells has distinct amiloride sensitive Na(+) channels.	Amiloride	367-376	keratin 18	Homo sapiens	128-132
20092750-6	2009	Immunocytochemistry staining showed CEA, CK8, CK18, CK19 was positive in sweat gland duct cells, RT-PCR revealed that CEA, CK8, CK18 and CK19 gene expression in sweat gland ductal cells, and Western Blot analysis showed the expression of CEA brand, CK8 brand, CK18 brand, and CK19 brand in sweat gland ductal cells, patch clamp indicated that this cells has distinct amiloride sensitive Na(+) channels.	Amiloride	367-376	keratin 19	Homo sapiens	137-141
19561078-5	2009	D54-MG cells transfected with the dominant negative constructs for ASIC1, alphaENaC, or gammaENaC showed reduced protein expression and a significant reduction in the amiloride-sensitive whole cell current as compared with untransfected D54-MG cells.	Amiloride	167-176	acid sensing ion channel subunit 1	Homo sapiens	67-72
19633071-6	2009	Impaired efferocytosis appears to be mediated through an amiloride-sensitive ion channel, because amiloride restores phagocytic competency in CFTR-deficient cells.	Amiloride	57-66	CF transmembrane conductance regulator	Homo sapiens	142-146
19758408-6	2009	Treatment with amiloride led to intracellular acidification and lower net H(+) flux in WT plants and to a decrease in intracellular Ca(2+) in WT and sos1 plants.	Amiloride	15-24	sodium proton exchanger, putative (NHX7) (SOS1)	Arabidopsis thaliana	149-153
19758408-11	2009	Amiloride affects SOS1 and other Na(+)/H(+) antiporters in plant cells because of its ability to decrease the H(+) gradient across the plasma membrane.	Amiloride	0-9	sodium proton exchanger, putative (NHX7) (SOS1)	Arabidopsis thaliana	18-22
19602550-0	2009	Molecular pharmacology of the amiloride analog 3-amino-6-chloro-5-[(4-chloro-benzyl)amino]-n-[[(2,4-dimethylbenzyl)-amino]iminomethyl]-pyrazinecarboxamide (CB-DMB) as a pan inhibitor of the Na+-Ca2+ exchanger isoforms NCX1, NCX2, and NCX3 in stably transfected cells.	Amiloride	30-39	solute carrier family 8 member A1	Homo sapiens	218-222
19602550-0	2009	Molecular pharmacology of the amiloride analog 3-amino-6-chloro-5-[(4-chloro-benzyl)amino]-n-[[(2,4-dimethylbenzyl)-amino]iminomethyl]-pyrazinecarboxamide (CB-DMB) as a pan inhibitor of the Na+-Ca2+ exchanger isoforms NCX1, NCX2, and NCX3 in stably transfected cells.	Amiloride	30-39	solute carrier family 8 member A2	Homo sapiens	224-228
19602550-0	2009	Molecular pharmacology of the amiloride analog 3-amino-6-chloro-5-[(4-chloro-benzyl)amino]-n-[[(2,4-dimethylbenzyl)-amino]iminomethyl]-pyrazinecarboxamide (CB-DMB) as a pan inhibitor of the Na+-Ca2+ exchanger isoforms NCX1, NCX2, and NCX3 in stably transfected cells.	Amiloride	30-39	solute carrier family 8 member A3	Homo sapiens	234-238
19339181-0	2009	Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).	Amiloride	0-9	acid sensing ion channel subunit 3	Homo sapiens	32-58
19474187-5	2009	When K(+) intake was increased by feeding overnight with a diet containing 10% KCl, amiloride reduced U(K)V from 7.5 +/- 0.7 to 1.3 +/- 0.1 micromol/min despite an increased plasma K(+) of 9 mM, again suggesting a major but not exclusive role for the Na(+) channel-dependent pathway of K(+) secretion.	Amiloride	84-93	sodium voltage-gated channel alpha subunit 8	Rattus norvegicus	251-264
19470678-2	2009	Here, we show that expression of Best1 in mouse renal collecting duct (CD) cells causes i) an increase in cell proliferation, ii) a loss of amiloride-sensitive Na(+) absorption, iii) induction of Ca(2+)-dependent Cl(-) conductance (CaCC), and iv) epithelial-to-mesenchymal transition.	Amiloride	140-149	bestrophin 1	Mus musculus	33-38
19282337-6	2009	In these 3 subjects, an inhibitor of the epithelial sodium channel, amiloride (10 muM), blocked the ability to distinguish salt concentrations and affected the LSP.	Amiloride	68-77	latexin	Homo sapiens	82-85
19302267-4	2009	Acidic pHe induced a cytoplasmic acidification (although cytoplasmic acidification was not sufficient for acidic pHe-induced lysosome trafficking and exocytosis) and inhibition of NHE activity with the amiloride derivative, EIPA or the anti-diabetic agent troglitazone prevented lysosome trafficking to the cell periphery.	Amiloride	202-211	solute carrier family 9 member C1	Homo sapiens	180-183
19436306-8	2009	u-PA and u-PAR function was inhibited with anti u-PA antibodies or the selective u-PA inhibitors amiloride or WXC-340, TLR-4 by TLR-4-blocking antibodies and NF-kappaB by the selective NF-kappaB inhibitor SN-50.	Amiloride	97-106	plasminogen activator, urokinase	Homo sapiens	0-4
19436306-8	2009	u-PA and u-PAR function was inhibited with anti u-PA antibodies or the selective u-PA inhibitors amiloride or WXC-340, TLR-4 by TLR-4-blocking antibodies and NF-kappaB by the selective NF-kappaB inhibitor SN-50.	Amiloride	97-106	plasminogen activator, urokinase receptor	Homo sapiens	9-14
19436306-8	2009	u-PA and u-PAR function was inhibited with anti u-PA antibodies or the selective u-PA inhibitors amiloride or WXC-340, TLR-4 by TLR-4-blocking antibodies and NF-kappaB by the selective NF-kappaB inhibitor SN-50.	Amiloride	97-106	plasminogen activator, urokinase	Homo sapiens	9-13
19436306-8	2009	u-PA and u-PAR function was inhibited with anti u-PA antibodies or the selective u-PA inhibitors amiloride or WXC-340, TLR-4 by TLR-4-blocking antibodies and NF-kappaB by the selective NF-kappaB inhibitor SN-50.	Amiloride	97-106	plasminogen activator, urokinase	Homo sapiens	9-13
19436306-8	2009	u-PA and u-PAR function was inhibited with anti u-PA antibodies or the selective u-PA inhibitors amiloride or WXC-340, TLR-4 by TLR-4-blocking antibodies and NF-kappaB by the selective NF-kappaB inhibitor SN-50.	Amiloride	97-106	toll like receptor 4	Homo sapiens	128-133
19706197-0	2009	Transduction of the MPG-tagged fusion protein into mammalian cells and oocytes depends on amiloride-sensitive endocytic pathway.	Amiloride	90-99	N-methylpurine DNA glycosylase	Homo sapiens	20-23
19706197-6	2009	The entry of MPG-EGFP is inhibited by amiloride, but cytochalasin D and methyl-beta-cyclodextrin did not inhibit the entry, suggesting that macropinocytosis is not involved in the transduction.	Amiloride	38-47	N-methylpurine DNA glycosylase	Homo sapiens	13-16
19706197-8	2009	The partial blockade of MPG-EGFP transduction by a dynamin mutant is abolished by the treatment of amiloride.	Amiloride	99-108	N-methylpurine DNA glycosylase	Homo sapiens	24-27
19706197-10	2009	CONCLUSION: The results show that the transduction of MPG fusion protein utilizes endocytic pathway(s) which is amiloride-sensitive and partially dynamin-dependent.	Amiloride	112-121	N-methylpurine DNA glycosylase	Homo sapiens	54-57
19458538-7	2009	Four weeks of treatment with amiloride, but not eplerenone, significantly ameliorated hypertension and kidney injury in Dahl salt-sensitive rats fed high-salt diet, suggesting aberrant aldosterone-independent activation of ENaC.	Amiloride	29-38	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	223-227
19458538-8	2009	CONCLUSION: These results suggest that inappropriate expression and activation of ENaC could be one of the underlying mechanisms by which Dahl salt-sensitive rats develop salt-sensitive hypertension and organ damage, and indicate a therapeutic benefit of amiloride in salt-sensitive hypertension where ENaC is excessively activated.	Amiloride	255-264	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	82-86
19458538-8	2009	CONCLUSION: These results suggest that inappropriate expression and activation of ENaC could be one of the underlying mechanisms by which Dahl salt-sensitive rats develop salt-sensitive hypertension and organ damage, and indicate a therapeutic benefit of amiloride in salt-sensitive hypertension where ENaC is excessively activated.	Amiloride	255-264	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	302-306
19367330-2	2009	Amiloride blocks the epithelial sodium channel (ENaC) located in the apical membrane of principal cells; hence one possibility is that ENaC is the main entry site for lithium and the beneficial effect of amiloride may be through inhibiting lithium entry.	Amiloride	0-9	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	48-52
19367330-2	2009	Amiloride blocks the epithelial sodium channel (ENaC) located in the apical membrane of principal cells; hence one possibility is that ENaC is the main entry site for lithium and the beneficial effect of amiloride may be through inhibiting lithium entry.	Amiloride	0-9	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	135-139
19367330-2	2009	Amiloride blocks the epithelial sodium channel (ENaC) located in the apical membrane of principal cells; hence one possibility is that ENaC is the main entry site for lithium and the beneficial effect of amiloride may be through inhibiting lithium entry.	Amiloride	204-213	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	48-52
19367330-2	2009	Amiloride blocks the epithelial sodium channel (ENaC) located in the apical membrane of principal cells; hence one possibility is that ENaC is the main entry site for lithium and the beneficial effect of amiloride may be through inhibiting lithium entry.	Amiloride	204-213	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	135-139
19367330-4	2009	Further amiloride or benzamil administration prevented this lithium-induced downregulation of AQP2.	Amiloride	8-17	aquaporin 2	Rattus norvegicus	94-98
19398659-3	2009	In this study, the contractile responses of perfused pressurized small-diameter rat mesenteric arteries to phenylephrine and serotonin were reduced by ENaC blockade with amiloride (75.1+/-3.2% and 16.9+/-2.3% of control values, respectively; P&lt;0.01) that was dose dependent (EC(50)=88.9+/-1.6 nmol/L).	Amiloride	170-179	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	151-155
19339181-0	2009	Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).	Amiloride	0-9	acid sensing ion channel subunit 3	Homo sapiens	60-65
19339181-1	2009	A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.	Amiloride	12-21	acid sensing ion channel subunit 3	Homo sapiens	114-140
19339181-1	2009	A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.	Amiloride	12-21	acid sensing ion channel subunit 3	Homo sapiens	142-147
19302589-1	2009	BACKGROUND AND PURPOSE: Amiloride derivatives are blockers of the Na(+)/H(+) exchanger (NHE) and at micromolar concentrations have protective effects on cardiac and brain ischaemia/reperfusion injury but at higher concentrations also induce apoptosis.	Amiloride	24-33	solute carrier family 9 member C1	Homo sapiens	66-86
19302589-1	2009	BACKGROUND AND PURPOSE: Amiloride derivatives are blockers of the Na(+)/H(+) exchanger (NHE) and at micromolar concentrations have protective effects on cardiac and brain ischaemia/reperfusion injury but at higher concentrations also induce apoptosis.	Amiloride	24-33	solute carrier family 9 member C1	Homo sapiens	88-91
19112100-3	2009	Coexpression of either S or E protein with human alpha-, beta-, and gamma-ENaC in Xenopus oocytes led to significant decreases of both amiloride-sensitive Na(+) currents and gamma-ENaC protein levels at their plasma membranes.	Amiloride	135-144	sodium channel, non voltage gated 1 gamma subunit S homeolog	Xenopus laevis	68-78
19193631-7	2009	Amiloride, in contrast, abolished PC2 currents in both the homomeric PC2 complexes and the heteromeric PC2/TRPC1 complexes, thus PC2/TRPC1 complexes have distinct functional properties from the homomeric complexes.	Amiloride	0-9	polycystin 2, transient receptor potential cation channel	Homo sapiens	34-37
19193631-7	2009	Amiloride, in contrast, abolished PC2 currents in both the homomeric PC2 complexes and the heteromeric PC2/TRPC1 complexes, thus PC2/TRPC1 complexes have distinct functional properties from the homomeric complexes.	Amiloride	0-9	polycystin 2, transient receptor potential cation channel	Homo sapiens	69-72
19193631-7	2009	Amiloride, in contrast, abolished PC2 currents in both the homomeric PC2 complexes and the heteromeric PC2/TRPC1 complexes, thus PC2/TRPC1 complexes have distinct functional properties from the homomeric complexes.	Amiloride	0-9	polycystin 2, transient receptor potential cation channel	Homo sapiens	69-72
19193631-7	2009	Amiloride, in contrast, abolished PC2 currents in both the homomeric PC2 complexes and the heteromeric PC2/TRPC1 complexes, thus PC2/TRPC1 complexes have distinct functional properties from the homomeric complexes.	Amiloride	0-9	transient receptor potential cation channel subfamily C member 1	Homo sapiens	107-112
19193631-7	2009	Amiloride, in contrast, abolished PC2 currents in both the homomeric PC2 complexes and the heteromeric PC2/TRPC1 complexes, thus PC2/TRPC1 complexes have distinct functional properties from the homomeric complexes.	Amiloride	0-9	polycystin 2, transient receptor potential cation channel	Homo sapiens	69-72
19193631-7	2009	Amiloride, in contrast, abolished PC2 currents in both the homomeric PC2 complexes and the heteromeric PC2/TRPC1 complexes, thus PC2/TRPC1 complexes have distinct functional properties from the homomeric complexes.	Amiloride	0-9	transient receptor potential cation channel subfamily C member 1	Homo sapiens	133-138
19150416-6	2009	TNF-alpha also inhibited the ENaC function as indicated by the reduction of amiloride-sensitive current (control 4.4, TNF-alpha 1.9 microA/cm(2)).	Amiloride	76-85	tumor necrosis factor	Rattus norvegicus	0-9
19150416-6	2009	TNF-alpha also inhibited the ENaC function as indicated by the reduction of amiloride-sensitive current (control 4.4, TNF-alpha 1.9 microA/cm(2)).	Amiloride	76-85	tumor necrosis factor	Rattus norvegicus	118-127
19131335-7	2009	Furthermore, pretreatment of H441 cells with the specific iNOS inhibitor 1400W (1 microM) resulted in a doubling of the amiloride-sensitive Na+ current in GFP+ cells.	Amiloride	120-129	nitric oxide synthase 2	Homo sapiens	58-62
19052103-6	2009	When grown on filters, mCCD-N21 cells exhibited a high transepithelial resistance as well as aldosterone- and/or vasopressin-induced amiloride-sensitive and -insensitive current.	Amiloride	133-142	arginine vasopressin	Homo sapiens	113-124
18949460-6	2009	RESULTS: In electrophysiological studies using hippocampal primary neuronal cultures, three ASIC inhibitors (PcTX-1, A-317567, and amiloride) produced concentration-dependent inhibition of acid-evoked currents.	Amiloride	131-140	acid sensing ion channel subunit 1	Homo sapiens	92-96
19028991-0	2009	Nociceptin/orphanin FQ peptide receptor agonist Ac-RYYRWKKKKKKK-NH2 (ZP120) induces antinatriuresis in rats by stimulation of amiloride-sensitive sodium reabsorption.	Amiloride	126-135	prepronociceptin	Rattus norvegicus	0-10
18636241-9	2009	Removal of extracellular Ca2+ or inhibition of the Ca2+-permeable cation channels with amiloride blunted the effects of arsenic on annexin V-binding and cell shrinkage.	Amiloride	87-96	annexin A5	Homo sapiens	131-140
19060118-6	2009	Further, recent pharmacological studies demonstrated that preventive, but not late, inhibition of increased airway Na(+) absorption with the ENaC blocker amiloride reduced morbidity and mortality in this murine model of CF lung disease.	Amiloride	154-163	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	141-145
19060118-7	2009	These results support a critical role of ENaC in the in vivo pathogenesis of CF lung disease and suggest that amiloride may be an effective preventive therapy for CF patients.	Amiloride	110-119	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	41-45
19095854-7	2009	RESULTS: In the fluid-instilled lung, ET-1 reduced alveolar fluid clearance by about 65%, an effect that was related to a decrease in amiloride-sensitive transepithelial Na(+) transport (P &lt; 0.001).	Amiloride	134-143	endothelin 1	Rattus norvegicus	38-42
19028925-7	2009	In the presence of amiloride and PSA (picrylsulfonic acid), pHi recovery was also significantly affected.	Amiloride	19-28	glucose-6-phosphate isomerase	Homo sapiens	60-63
18990692-3	2009	In Xenopus oocytes expressing human alpha-, beta-, and gammaENaC, amiloride-sensitive current was altered by protons in the physiologically relevant range (pH 8.5-6.0).	Amiloride	66-75	sodium channel epithelial 1 subunit gamma	Homo sapiens	36-64
19050954-7	2009	pHi recovery was also greatly reduced in the presence of 4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid (DIDS) and amiloride.	Amiloride	119-128	glucose-6-phosphate isomerase	Bos taurus	0-3
19255496-5	2009	In voltage-clamp experiments we found that amiloride-sensitive ENaC current (Iami) and conductance (Gami) peak at a [Na+](i) of approximately 10 mM Na+, but were significantly reduced in 5 mM and 20 mM [Na+](i).	Amiloride	43-52	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	63-67
19344080-4	2009	PHA1 is caused by mutations in genes encoding either subunits of the amiloride-sensitive epithelial sodium channel (ENaC) or mineralocorticoid receptor (MR) inherited in an autosomal recessive or dominant form, respectively.	Amiloride	69-78	sodium channel epithelial 1 subunit gamma	Homo sapiens	0-4
18813314-8	2008	We found an increased risk of SCC (IRR of 1.79 (95% confidence interval (CI): 1.45-2.21)) and MM (IRR of 1.43 (95% CI: 1.09-1.88)) among users of combined amiloride and hydrochlorothiazide therapy.	Amiloride	155-164	serpin family B member 3	Homo sapiens	30-33
18784260-6	2008	In this study, we measured the amiloride-sensitive equivalent short-circuit current in isolated, perfused collecting ducts and found it increased by fivefold in CLDN16 KD mice compared with wild-type (WT) mice.	Amiloride	31-40	claudin 16	Mus musculus	161-167
18784260-8	2008	Under amiloride treatment, CLDN16 KD mice developed hyponatremia and the renal fractional excretion of Na(+) was twofold higher in CLDN16 KD compared with WT mice.	Amiloride	6-15	claudin 16	Mus musculus	27-33
18784260-8	2008	Under amiloride treatment, CLDN16 KD mice developed hyponatremia and the renal fractional excretion of Na(+) was twofold higher in CLDN16 KD compared with WT mice.	Amiloride	6-15	claudin 16	Mus musculus	131-137
18849497-2	2008	However, inhalation therapy with the ENaC blocker amiloride did not have therapeutic benefits in patients with CF with established lung disease.	Amiloride	50-59	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	37-41
18723760-0	2008	AICAR decreases the activity of two distinct amiloride-sensitive Na+-permeable channels in H441 human lung epithelial cell monolayers.	Amiloride	45-54	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	0-5
18723760-5	2008	Amiloride at 1 microM inhibited HSC activity and 56% of short-circuit current (I(sc)), whereas 10 microM amiloride partially reduced NSC activity and inhibited a further 30% of I(sc).	Amiloride	0-9	fucosyltransferase 1 (H blood group)	Homo sapiens	32-35
18653483-3	2008	Whole-cell patch-clamp recordings from principal cells of connecting tubules (CNT) or cortical collecting ducts (CCD) demonstrated that addition of trypsin (20 microg/ml) to the bath solution increased the ENaC-mediated amiloride-sensitive whole cell current (DeltaIAmi) in the majority of cells.	Amiloride	220-229	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	206-210
18670436-7	2008	The MEC-4(A149V)+MEC-10(d) channel conducts elevated Na(+) and Ca(2+) currents (with a disproportionate increase in Ca(2+) current) in the Xenopus oocyte expression system, and exhibits altered binding of the channel inhibitor amiloride.	Amiloride	227-236	Degenerin mec-4	Caenorhabditis elegans	4-9
18579705-7	2008	Both amiloride- and ouabain-sensitive pathways of O(2)(-) production were elevated following 3 days of high (4.0%) NaCl feeding in mTAL of SS and SS.13(BN) rats.	Amiloride	5-14	talipes	Mus musculus	131-135
18632802-4	2008	Coexpression of Usp10 in ENaC-transfected HEK-293 cells causes a more than fivefold increase in amiloride-sensitive Na+ currents, as measured by whole cell patch clamping.	Amiloride	96-105	ubiquitin specific peptidase 10	Homo sapiens	16-21
18787641-6	2008	Furthermore, measurement of alveolar fluid clearance (AFC) demonstrated that A2BAR signaling enhanced amiloride-sensitive fluid transport and elevation of pulmonary cAMP levels following VILI, suggesting that A2BAR agonist treatment protects by drying out the lungs.	Amiloride	102-111	adenosine A2b receptor	Mus musculus	77-82
18787641-6	2008	Furthermore, measurement of alveolar fluid clearance (AFC) demonstrated that A2BAR signaling enhanced amiloride-sensitive fluid transport and elevation of pulmonary cAMP levels following VILI, suggesting that A2BAR agonist treatment protects by drying out the lungs.	Amiloride	102-111	adenosine A2b receptor	Mus musculus	209-214
18991662-4	2008	Recently we provided the in-vivo data on anticonvulsant efficacy of amiloride (an NHE inhibitor) in different animal models of seizure and epilepsy.	Amiloride	68-77	solute carrier family 9 member C1	Homo sapiens	82-85
18847376-2	2008	KB-R7943, EIPA, or amiloride, which respectively inhibit NCX, NHE-1, or NCX, NHE-1, and ASIC1a (acid-sensing ion channel type 1a), was infused intraventricularly over a 60-min period immediately prior to TBI.	Amiloride	19-28	solute carrier family 8 member A1	Rattus norvegicus	57-60
18847376-2	2008	KB-R7943, EIPA, or amiloride, which respectively inhibit NCX, NHE-1, or NCX, NHE-1, and ASIC1a (acid-sensing ion channel type 1a), was infused intraventricularly over a 60-min period immediately prior to TBI.	Amiloride	19-28	solute carrier family 9 member A1	Rattus norvegicus	62-67
18847376-2	2008	KB-R7943, EIPA, or amiloride, which respectively inhibit NCX, NHE-1, or NCX, NHE-1, and ASIC1a (acid-sensing ion channel type 1a), was infused intraventricularly over a 60-min period immediately prior to TBI.	Amiloride	19-28	solute carrier family 8 member A1	Rattus norvegicus	72-75
18847376-2	2008	KB-R7943, EIPA, or amiloride, which respectively inhibit NCX, NHE-1, or NCX, NHE-1, and ASIC1a (acid-sensing ion channel type 1a), was infused intraventricularly over a 60-min period immediately prior to TBI.	Amiloride	19-28	solute carrier family 9 member A1	Rattus norvegicus	77-82
18847376-6	2008	Amiloride (100 nmoles) significantly attenuated the TBI-induced acute reduction in astrocyte GFAP immunoreactivity.	Amiloride	0-9	glial fibrillary acidic protein	Rattus norvegicus	93-97
18579705-8	2008	We conclude that mTAL from SS rats exhibit enhanced amiloride-sensitive O(2)(-) production.	Amiloride	52-61	talipes	Mus musculus	17-21
18606547-3	2008	Amiloride was found to protect substantia nigra (SNc) neurons from MPTP-induced degeneration, as determined by attenuated reductions in striatal tyrosine hydroxylase (TH) and dopamine transporter (DAT) immunohistochemistry, as well as smaller declines in striatal DAT radioligand binding and dopamine levels.	Amiloride	0-9	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	175-195
18596116-9	2008	Amiloride increased maximal urinary osmolality and AQP2 excretion.	Amiloride	0-9	aquaporin 2	Homo sapiens	51-55
18596116-10	2008	CONCLUSIONS: By inference, amiloride-induced reduction of lithium uptake in the principal cells of the collecting duct improves responsiveness to AVP-stimulated translocation of AQP2 to the apical membrane of the principal cells.	Amiloride	27-36	aquaporin 2	Homo sapiens	178-182
18366077-5	2008	This activity and PGN-induced aggregation were inhibited by the uPA inhibitor amiloride.	Amiloride	78-87	plasminogen activator, urokinase	Homo sapiens	64-67
18606547-3	2008	Amiloride was found to protect substantia nigra (SNc) neurons from MPTP-induced degeneration, as determined by attenuated reductions in striatal tyrosine hydroxylase (TH) and dopamine transporter (DAT) immunohistochemistry, as well as smaller declines in striatal DAT radioligand binding and dopamine levels.	Amiloride	0-9	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	197-200
18606547-3	2008	Amiloride was found to protect substantia nigra (SNc) neurons from MPTP-induced degeneration, as determined by attenuated reductions in striatal tyrosine hydroxylase (TH) and dopamine transporter (DAT) immunohistochemistry, as well as smaller declines in striatal DAT radioligand binding and dopamine levels.	Amiloride	0-9	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	264-267
18524855-7	2008	The hypertension was probably mediated by ENaC overactivity because 1) Nedd4-2 null mice had higher expression levels of all three ENaC subunits in kidney, but not of other Na+ transporters; 2) the downregulation of ENaC function in colon was impaired; and 3) NaCl-sensitive hypertension was substantially reduced in the presence of amiloride, a specific inhibitor of ENaC.	Amiloride	333-342	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	42-46
18524855-7	2008	The hypertension was probably mediated by ENaC overactivity because 1) Nedd4-2 null mice had higher expression levels of all three ENaC subunits in kidney, but not of other Na+ transporters; 2) the downregulation of ENaC function in colon was impaired; and 3) NaCl-sensitive hypertension was substantially reduced in the presence of amiloride, a specific inhibitor of ENaC.	Amiloride	333-342	neural precursor cell expressed, developmentally down-regulated gene 4-like	Mus musculus	71-78
18717264-6	2008	The NE T1 transporter was more sensitive to amiloride than the microsomal T1.	Amiloride	44-53	neuroepithelial cell transforming 1	Rattus norvegicus	4-9
18326692-5	2008	In vitro expression of MCOLN1 in liposomes showed that the c.1615delG mutated channel had significantly reduced conductance compared with wild-type mucolipin-1, whereas the inhibitory effect of low pH and amiloride remained intact.	Amiloride	205-214	mucolipin TRP cation channel 1	Homo sapiens	23-29
18492821-4	2008	The PRL-stimulated Isc was significantly reduced by pretreatment with an apical addition of 5-nitro-2-(3-phenylpropylamino) benzoic acid (200 microM), diphenylamine-2-carboxylic acid (1 mM) or 4,4"-diisothiocyanatostilbene-2,2"-disulfonic acid (200 microM), Cl(-) channel blockers, but not by amiloride (10 microM), a Na(+) channel blocker.	Amiloride	293-302	prolactin	Homo sapiens	4-7
18665318-5	2008	Ion substitution experiments showed that the amiloride-sensitive current carried cations with a permeability rank order of Li+ &gt; Na+ &gt; K+ &gt; NMDG (PLi/PNa = 1.3, PK/PNa = 0.6, PNMDG/PNa = 0.2).	Amiloride	45-54	serpin family F member 2	Homo sapiens	155-158
18600791-7	2008	Inhibition of the Na(+)/H(+) exchanger family by amiloride suppressed RANKL-induced osteoclast fusion and bone resorption.	Amiloride	49-58	TNF superfamily member 11	Homo sapiens	70-75
18310228-4	2008	The glucocorticoid/SGK1-induced GNa in single cells discriminated poorly between Na+ and K+ (PNa/PK approximately 0.6), was insensitive to amiloride (1 mM), but was partially blocked by LaCl3 (La3+; 1 mM, approximately 80%), pimozide (0.1 mM, approximately 40%), and dichlorobenzamil (15 microM, approximately 15%).	Amiloride	139-148	serum/glucocorticoid regulated kinase 1	Homo sapiens	19-23
18344315-0	2008	Amiloride derivatives and a nonpeptidic antagonist bind at two distinct allosteric sites in the human gonadotropin-releasing hormone receptor.	Amiloride	0-9	gonadotropin releasing hormone receptor	Homo sapiens	102-141
18344315-3	2008	In the present study, allosteric modulation of the human gonadotropin-releasing hormone (GnRH) receptor by amiloride analogs [e.g., 5-(N,N-hexamethylene)amiloride (HMA)] and a nonpeptide antagonistic furan derivative (FD-1) was studied.	Amiloride	107-116	gonadotropin releasing hormone receptor	Homo sapiens	57-103
18308722-4	2008	In Ussing chamber experiments with mouse airways, colon, and cultured M1-collecting duct cells, amiloride-sensitive Na(+) transport was inhibited dose-dependently by the selective CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB).	Amiloride	96-105	casein kinase 2, alpha prime polypeptide	Mus musculus	180-183
18308722-6	2008	Expression of a trimeric channel lacking both CK2 sites (alphabeta(S631A)gamma(T599A)) produced a largely attenuated amiloride-sensitive whole cell conductance and rendered the mutant channel insensitive to CK2.	Amiloride	117-126	casein kinase 2, alpha prime polypeptide	Mus musculus	46-49
18309088-3	2008	In this study, we report that in human airway epithelial CF15 cells treated with the CFTR corrector miglustat (n-butyldeoxynojyrimicin), whole-cell patch-clamp experiments showed reduced amiloride-sensitive ENaC current in parallel with a rescue of defective CFTR Cl- channel activity activated by forskolin and genistein.	Amiloride	187-196	CF transmembrane conductance regulator	Homo sapiens	85-89
18309088-6	2008	In excised nasal epithelium of cftr(F508del/F508del) mice, like with CF15 cells, we found normalization of amiloride-sensitive Isc.	Amiloride	107-116	cystic fibrosis transmembrane conductance regulator	Mus musculus	31-35
18309088-7	2008	Moreover, oral administration of miglustat (6 days) decreased the amiloride-sensitive Isc in cftr(F508del/F508del) mice but had no effect on cftr-/- mice.	Amiloride	66-75	cystic fibrosis transmembrane conductance regulator	Mus musculus	93-97
18363778-4	2008	We investigated CD94/NKG2A endocytosis and found that it occurs by an amiloride-sensitive, Rac1-dependent macropinocytic-like process; however, it does not require clathrin, dynamin, ADP ribosylation factor-6, phosphoinositide-3 kinase or the actin cytoskeleton.	Amiloride	70-79	killer cell lectin like receptor D1	Homo sapiens	16-20
18363778-4	2008	We investigated CD94/NKG2A endocytosis and found that it occurs by an amiloride-sensitive, Rac1-dependent macropinocytic-like process; however, it does not require clathrin, dynamin, ADP ribosylation factor-6, phosphoinositide-3 kinase or the actin cytoskeleton.	Amiloride	70-79	killer cell lectin like receptor C1	Homo sapiens	21-26
18363778-4	2008	We investigated CD94/NKG2A endocytosis and found that it occurs by an amiloride-sensitive, Rac1-dependent macropinocytic-like process; however, it does not require clathrin, dynamin, ADP ribosylation factor-6, phosphoinositide-3 kinase or the actin cytoskeleton.	Amiloride	70-79	Rac family small GTPase 1	Homo sapiens	91-95
18310228-6	2008	These data therefore 1) confirm that H441 cells can express selective or nonselective GNa (14, 48), 2) show that these conductances are both induced by glucocorticoids/SGK1 and subject to PI3K-dependent regulation, and 3) establish that cell-cell contact is vitally important to the development of Na+ selectivity and amiloride sensitivity.	Amiloride	318-327	serum/glucocorticoid regulated kinase 1	Homo sapiens	168-172
18323855-4	2008	TRPP2/TRPC1 is activated in response to G-protein-coupled receptor activation and shows a pattern of single-channel conductance, amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone.	Amiloride	129-138	polycystin 2, transient receptor potential cation channel	Homo sapiens	0-5
18323855-4	2008	TRPP2/TRPC1 is activated in response to G-protein-coupled receptor activation and shows a pattern of single-channel conductance, amiloride sensitivity and ion permeability distinct from that of TRPP2 or TRPC1 alone.	Amiloride	129-138	transient receptor potential cation channel subfamily C member 1	Homo sapiens	6-11
18216143-10	2008	Reduced AQP2, AQP3, and urea transporter (UT-A1) expression was significantly reversed following amiloride therapy.	Amiloride	97-106	aquaporin 2	Rattus norvegicus	8-12
18216143-10	2008	Reduced AQP2, AQP3, and urea transporter (UT-A1) expression was significantly reversed following amiloride therapy.	Amiloride	97-106	aquaporin 3 (Gill blood group)	Rattus norvegicus	14-18
18333890-7	2008	We also propose that certain diuretics (amiloride and spironolactone), by targeting the distal nephron that expresses PPARgamma in collecting duct cells, might be of benefit in ameliorating the fluid retention and oedema associated with TZDs.	Amiloride	40-49	peroxisome proliferator activated receptor gamma	Homo sapiens	118-127