PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16389569-3	2005	METHODS: CRP-induced signalling events were examined in THP-1 and primary monocytes, measuring Syk phosphorylation by Western blotting, intracellular Ca(2+) ([Ca(2+)](i)) by Indo-1 fluorescence and surface expression of CD11b by flow cytometry.	indo-1	174-180	C-reactive protein	Homo sapiens	9-12
2731227-2	1989	When stimulated with the agonists, angiotensin II and arginine vasopressin, cells incubated with low concentrations of fura-2 or indo-1 (less than 1 microM) produced Ca2+ transients characterized by a small increase followed by a dramatic decrease in fluorescence below the original baseline.	indo-1	129-135	angiotensinogen	Rattus norvegicus	35-49
2731227-2	1989	When stimulated with the agonists, angiotensin II and arginine vasopressin, cells incubated with low concentrations of fura-2 or indo-1 (less than 1 microM) produced Ca2+ transients characterized by a small increase followed by a dramatic decrease in fluorescence below the original baseline.	indo-1	129-135	arginine vasopressin	Rattus norvegicus	63-74
28771237-5	2017	[Ca2+]i measurements are most commonly performed in intact single fibers using ratiometric fluorescent indicators such as indo-1 or fura-2.	indo-1	122-128	carbonic anhydrase 2	Homo sapiens	1-4
3106489-3	1987	An increase in [Ca2+]i occurred within 1 min in indo-1-loaded PBMC after the addition of CD5 monoclonal antibodies and cross-linking with a second step anti-mouse kappa light chain antibody.	indo-1	48-54	CD5 molecule	Homo sapiens	89-92
26223765-5	2015	In some experiments, simultaneous force and intracellular Ca(2+) or pH (pH(i)) were measured with Indo-1 or Carboxy-SNARF, respectively.	indo-1	98-104	glucose-6-phosphate isomerase	Rattus norvegicus	72-77
19244356-3	2009	We used indo-1-based microfluorimetry in the presence of cyclopiazonic acid to study the rate of PMCA-mediated recovery of Ca(2+) elevated by a brief train of action potentials.	indo-1	8-14	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	97-101
17209005-8	2007	At the single cardiomyocyte level, VLCAD(-/-) cardiomyocytes showed significant increase in diastolic indo 1 and fura 2 fluorescence, with increased Ca(2+) transient amplitude.	indo-1	102-108	acyl-Coenzyme A dehydrogenase, very long chain	Mus musculus	35-45
15655501-1	2005	Experiments were carried out in isolated canine ventricular trabeculae and acetoxymethylester of indo-1-loaded single myocytes to elucidate the role of protein tyrosine kinase (PTK) in the inotropic effect of endothelin-1 (ET-1) induced by crosstalk with norepinephrine (NE).	indo-1	97-103	Janus kinase 1	Canis lupus familiaris	177-180
16358785-1	2005	The properties of the Ca2+ channel induced by a calmodulin inhibitor in Ehrlich ascites tumor cells were investigated using fluorescent indicators Indo-1 and chlortetracycline.	indo-1	147-153	calmodulin 2	Mus musculus	48-58
11237323-5	2001	The cation-bound Mag-indo1 fluorescence resulted partially (20 to 50%) from the cytosol for 30% of the cells, and totally from compartments for 70% of the cells.	indo-1	21-26	myelin associated glycoprotein	Homo sapiens	17-20
15187020-11	2004	Exposing Indo-1-labeled K562 cells to NmU induced an intracellular Ca(++) flux consistent with engagement of the NMU1R.	indo-1	9-15	neuromedin U	Homo sapiens	38-41
15187020-11	2004	Exposing Indo-1-labeled K562 cells to NmU induced an intracellular Ca(++) flux consistent with engagement of the NMU1R.	indo-1	9-15	neuromedin U receptor 1	Homo sapiens	113-118
14609817-10	2003	CNP increased cell shortening and systolic Cai2+ levels, and accelerated Cai2+ decay in isolated, Indo-1/AM-loaded WT cardiomyocytes, and these effects were enhanced in PKG I-overexpressing cardiomyocytes.	indo-1	98-104	natriuretic peptide type C	Mus musculus	0-3
11172754-5	2001	Using a Ca2+-sensitive dye Indo-1, Cd2+ was found to elevate the intracellular Ca2+ concentration [Ca2+](i) (both in the cytoplasm and the nucleus).	indo-1	27-33	Cd2 molecule	Rattus norvegicus	35-38
9473355-3	1998	Human endothelial cells preloaded with Indo-1 exhibited rapid calcium mobilization in response to thrombin.	indo-1	39-45	coagulation factor II, thrombin	Homo sapiens	98-106
10468529-4	1999	One mPLB, K3E/R14E, pentamerized with endogenous PLB in neonatal myocytes and resulted in a 45% increase in the affinity of SERCA2 for Ca(2+) and 27% faster diastolic Ca(2+) decline as determined by SR (45)Ca uptake assays and by indo 1-facilitated Ca(2+) transient measurement, respectively.	indo-1	230-236	phospholamban	Homo sapiens	5-8
10468529-4	1999	One mPLB, K3E/R14E, pentamerized with endogenous PLB in neonatal myocytes and resulted in a 45% increase in the affinity of SERCA2 for Ca(2+) and 27% faster diastolic Ca(2+) decline as determined by SR (45)Ca uptake assays and by indo 1-facilitated Ca(2+) transient measurement, respectively.	indo-1	230-236	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	124-130
9614238-4	1998	Depolarization with 40-60 mM K+ was used to analyze the activity of Ca2+ VOCs in Indo-1-loaded astrocytes in acute slices from the visual cortex and the CA1 hippocampal region of developing rats.	indo-1	81-87	carbonic anhydrase 2	Rattus norvegicus	68-71
9023766-3	1997	Here, we have used the fluorescent calcium indicator, indo-1 AM to record [Ca2+]i from single cells.	indo-1	54-60	carbonic anhydrase 2	Rattus norvegicus	75-78
9049249-5	1997	The indicated resting Cam of 100-200 nM is similar to the resting Cac reported by the probes indo-1 and Calcium Green, or its dextran conjugate in the cytoplasm.	indo-1	93-99	carbonic anhydrase 2	Homo sapiens	66-69
9038920-2	1997	We investigated the functional significance of inducible nitric oxide synthase (iNOS) in indo 1-loaded beating myocytes with regard to intracellular Ca2+ concentration ([Ca2+]i) and cell contraction.	indo-1	89-95	nitric oxide synthase 2	Rattus norvegicus	47-78
9038920-2	1997	We investigated the functional significance of inducible nitric oxide synthase (iNOS) in indo 1-loaded beating myocytes with regard to intracellular Ca2+ concentration ([Ca2+]i) and cell contraction.	indo-1	89-95	nitric oxide synthase 2	Rattus norvegicus	80-84
7608117-1	1995	The change of cytosolic Ca2+ concentration ([Ca2+]i) caused by vasopressin was examined in indo-1-loaded A7r5 smooth muscle cells by use of the high-performance laser cytometer and ratiometric fluorescence method.	indo-1	91-97	arginine vasopressin	Rattus norvegicus	63-74
8974061-6	1996	In the single cardiac myocyte IGF-1 increased, the peak cytosolic free Ca2+ concentration, the amplitude of the Ca2+ transient and the time to peak Ca2+ as measured with the fluorescent bioprobe Indo-1 AM.	indo-1	195-201	insulin-like growth factor 1	Rattus norvegicus	30-35
8914860-5	1996	The cytosolic Ca2+ mobilization in response to the NK1 agonist was monitored both by spectrofluorimetric and single-cell image analysis determinations on adherent cells loaded with the Ca(2+)-sensitive fluorescent indicators Fura-2/AM and Indo-1, respectively.	indo-1	239-245	tachykinin receptor 1	Homo sapiens	51-54
8006954-4	1994	These membrane potential changes temporally correlated with Ca2+ influx from the extracellular medium as measured fluorimetrically with indo-1.	indo-1	136-142	carbonic anhydrase 2	Homo sapiens	60-63
7526331-1	1994	Actions of growth-hormone-releasing hormone (GHRH) on single rat anterior pituitary cells were studied using indo-1 fluorescence to monitor changes in intracellular calcium, [Ca2+]i, and perforated-patch recording to measure changes in membrane potential and ionic currents.	indo-1	109-115	growth hormone releasing hormone	Rattus norvegicus	45-49
7875042-4	1994	Verapamil and cyclosporin (CsA), both inhibitors of P-gp, enhanced accumulation of indo-1 in these cells and therefore allowed for improved intracellular calcium measurements.	indo-1	83-89	phosphoglycolate phosphatase	Homo sapiens	52-56
1450945-1	1992	Treatment of single rat hippocampal neurons with 200 pM recombinant HIV-1 envelope glycoprotein, gp120, resulted in large increases in the intracellular free calcium concentration ([Ca2+]i) as measured with indo-1-based microfluorimetry.	indo-1	207-213	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	97-102
8145155-15	1993	Depolarization-induced Sr2+ entry through voltage-dependent Ca2+ channels could evoke an increase in indo-1 fluorescence which occurred after the termination of the voltage step.	indo-1	101-107	carbonic anhydrase 2	Rattus norvegicus	60-63
8223566-7	1993	In marked contrast, EGTA completely blocked the Ca2+ response stimulated by C3a in neutrophils labeled with either Indo-1/AM or Fluo-3.	indo-1	115-121	complement C3	Homo sapiens	76-79
8245824-5	1993	Cai was measured in myocytes loaded with indo-1/free acid and Cam was monitored in cells loaded with indo-1/AM after quenching cytosolic indo-1 fluorescence with MnCl2.	indo-1	101-107	calmodulin 3	Homo sapiens	62-65
8245824-5	1993	Cai was measured in myocytes loaded with indo-1/free acid and Cam was monitored in cells loaded with indo-1/AM after quenching cytosolic indo-1 fluorescence with MnCl2.	indo-1	101-107	calmodulin 3	Homo sapiens	62-65
7508063-11	1993	Calcium mobilization evoked by thrombin stimulation and measured with the fluorescent dye Indo 1 was also reduced in presence of indapamide by 30%.	indo-1	90-96	coagulation factor II, thrombin	Homo sapiens	31-39
1332876-2	1992	ET-1 induced an elevation of the intracellular levels of Ca2+([Ca2+]i) as measured with the fluorescent indicator indo-1, which consists of an initial transient increase and an ensuing sustained plateau.	indo-1	114-120	endothelin 1	Homo sapiens	0-4
1696888-9	1990	Approximately 7% of anterior pituitary cells responded to LHRH (1 or 10 nM) with significant increases in Indo-1 ratios, indicative of an increase in the concentration of free cytosolic Ca2+.	indo-1	106-112	gonadotropin releasing hormone 1	Rattus norvegicus	58-62
1420876-5	1992	Binding of indo-1 in permeabilized myocytes was approximately 60% higher at a saturating Ca concentration (pCa = 3), than under Ca free conditions (1 mM EGTA).	indo-1	11-17	prostate cancer associated 3	Homo sapiens	107-114
1350269-7	1992	Surprisingly, Ca2+ mobilization was only seen when two anti-Qa-2 antibodies reactive to separate structural domains were co-crosslinked on the surface of Indo-1 loaded T cells with a suboptimal concentration of anti-CD3.	indo-1	154-160	Qa lymphocyte antigen 2 region	Mus musculus	60-64
2187055-2	1990	In indo 1-loaded cells, endothelin-1, endothelin-2, endothelin-3, and sarafotoxin induce the rapid mobilization of intracellular Ca2+ stores and promote a more slowly developing influx of Ca2+.	indo-1	3-9	endothelin 1	Rattus norvegicus	24-36
1694785-1	1990	The relationship between thrombin-evoked changes in intracellular calcium concentration [( Ca2+]i) and aggregation was examined in Indo-1-loaded human platelets.	indo-1	131-137	coagulation factor II, thrombin	Homo sapiens	25-33
2187055-2	1990	In indo 1-loaded cells, endothelin-1, endothelin-2, endothelin-3, and sarafotoxin induce the rapid mobilization of intracellular Ca2+ stores and promote a more slowly developing influx of Ca2+.	indo-1	3-9	endothelin 2	Rattus norvegicus	38-50
2187055-2	1990	In indo 1-loaded cells, endothelin-1, endothelin-2, endothelin-3, and sarafotoxin induce the rapid mobilization of intracellular Ca2+ stores and promote a more slowly developing influx of Ca2+.	indo-1	3-9	endothelin 3	Rattus norvegicus	52-64
2317548-6	1990	Cytoplasmic viscosity (eta) in Madin-Darby canine kidney (MDCK) cells and Swiss 3T3 fibroblasts was examined from anisotropy images and time-resolved fluorescence decay of the cytoplasmic probes 2,7-bis-carboxyethyl-5 (and 6)-carboxy-fluorescein (BCECF) and indo-1.	indo-1	258-264	endothelin receptor type A	Canis lupus familiaris	23-26
2354495-6	1990	We have used this system to obtain images of [Ca2+]i at 16.7 ms intervals in voltage-clamped single cardiac cells perfused internally with Indo-1 (pentapotassium salt).	indo-1	139-145	carbonic anhydrase 2	Homo sapiens	46-49