PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18555807-2	2008	The yeast sterol 3-ketoreductase (Erg27p) required for C-4 demethylation of sterols has previously been shown to also be required for the function of the upstream oxidosqualene cyclase/lanosterol synthase (Erg7p); thus, erg27 mutants accumulate oxidosqualenes as precursors rather than 3-ketosterones.	oxidosqualene	163-176	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	34-40
23022663-5	2013	This strain which was crossed to a wildtype and daughter segregants showed an accumulation of squalene epoxides as well as ergosterol indicating that the mutation entailed a leaky block at ERG7.	oxidosqualene	94-111	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	189-193
23022663-10	2013	Both FGerg27 and erg27 strains containing this fusion plasmid and the mouse ERG27 orthologue showed restoration of ergosterol biosynthesis with minimal accumulation of squalene epoxides.	oxidosqualene	168-185	hydroxysteroid (17-beta) dehydrogenase 7	Mus musculus	76-81
22732192-1	2012	The Cys703 to Ile or His mutation within Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase ERG7 (ERG7(C703I/H)) generates an unusual truncated bicyclic rearranged intermediate, (8R,9R,10R)-polypoda-5,13E,17E,21-tetraen-3beta-ol, related to iridal-skeleton triterpenoid.	oxidosqualene	66-79	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	99-103
22732192-1	2012	The Cys703 to Ile or His mutation within Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase ERG7 (ERG7(C703I/H)) generates an unusual truncated bicyclic rearranged intermediate, (8R,9R,10R)-polypoda-5,13E,17E,21-tetraen-3beta-ol, related to iridal-skeleton triterpenoid.	oxidosqualene	66-79	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	105-109
18555807-2	2008	The yeast sterol 3-ketoreductase (Erg27p) required for C-4 demethylation of sterols has previously been shown to also be required for the function of the upstream oxidosqualene cyclase/lanosterol synthase (Erg7p); thus, erg27 mutants accumulate oxidosqualenes as precursors rather than 3-ketosterones.	oxidosqualene	163-176	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	206-211
18555807-2	2008	The yeast sterol 3-ketoreductase (Erg27p) required for C-4 demethylation of sterols has previously been shown to also be required for the function of the upstream oxidosqualene cyclase/lanosterol synthase (Erg7p); thus, erg27 mutants accumulate oxidosqualenes as precursors rather than 3-ketosterones.	oxidosqualene	163-176	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	220-225
18555807-2	2008	The yeast sterol 3-ketoreductase (Erg27p) required for C-4 demethylation of sterols has previously been shown to also be required for the function of the upstream oxidosqualene cyclase/lanosterol synthase (Erg7p); thus, erg27 mutants accumulate oxidosqualenes as precursors rather than 3-ketosterones.	oxidosqualene	245-259	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	34-40
18555807-2	2008	The yeast sterol 3-ketoreductase (Erg27p) required for C-4 demethylation of sterols has previously been shown to also be required for the function of the upstream oxidosqualene cyclase/lanosterol synthase (Erg7p); thus, erg27 mutants accumulate oxidosqualenes as precursors rather than 3-ketosterones.	oxidosqualene	245-259	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	206-211
18555807-2	2008	The yeast sterol 3-ketoreductase (Erg27p) required for C-4 demethylation of sterols has previously been shown to also be required for the function of the upstream oxidosqualene cyclase/lanosterol synthase (Erg7p); thus, erg27 mutants accumulate oxidosqualenes as precursors rather than 3-ketosterones.	oxidosqualene	245-259	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	220-225
11706015-1	2002	Oxidosqualene cyclase of the yeast encoded by the ERG7 gene converts oxidosqualene to lanosterol, the first cyclic component of sterol biosynthesis.	oxidosqualene	69-82	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	50-54
17186944-2	2007	Previously, we demonstrated that partial inhibition of oxidosqualene:lanosterol cyclase (OSC) stimulated synthesis of the LXR agonist 24(S),25-epoxycholesterol (24(S),25-epoxy) and enhanced ABCA1-mediated cholesterol efflux.	oxidosqualene	55-68	ATP binding cassette subfamily A member 1	Homo sapiens	190-195
16683806-1	2006	Site-saturated mutagenesis experiments were carried out on the His234 residue of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase (ERG7) to characterize its functional role in ERG7 activity and to determine its effect on the oxidosqualene cyclization/rearrangement reaction.	oxidosqualene	106-119	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	140-144
16683806-1	2006	Site-saturated mutagenesis experiments were carried out on the His234 residue of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase (ERG7) to characterize its functional role in ERG7 activity and to determine its effect on the oxidosqualene cyclization/rearrangement reaction.	oxidosqualene	106-119	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	185-189
16120615-7	2005	Chromosomal integration of ERG1 ERG7 at their loci in erg26-1ts ets1-1 and erg26-1ts and ets2-1 mutants, respectively, results in the loss of accumulation of squalene and squalene epoxide, re-accumulation of 4-carboxysterols and cell inviability at high temperature.	oxidosqualene	171-187	potassium voltage-gated channel subfamily H member 2	Homo sapiens	27-31
16120615-7	2005	Chromosomal integration of ERG1 ERG7 at their loci in erg26-1ts ets1-1 and erg26-1ts and ets2-1 mutants, respectively, results in the loss of accumulation of squalene and squalene epoxide, re-accumulation of 4-carboxysterols and cell inviability at high temperature.	oxidosqualene	171-187	ETS proto-oncogene 1, transcription factor	Homo sapiens	64-70
16120615-7	2005	Chromosomal integration of ERG1 ERG7 at their loci in erg26-1ts ets1-1 and erg26-1ts and ets2-1 mutants, respectively, results in the loss of accumulation of squalene and squalene epoxide, re-accumulation of 4-carboxysterols and cell inviability at high temperature.	oxidosqualene	171-187	ETS proto-oncogene 2, transcription factor	Homo sapiens	89-93
17107079-1	2006	Arabidopsis thaliana LUP1 (At1g78970) catalyzes the cyclization of oxidosqualene into lupeol and 3beta,20-dihydroxylupane (lupanediol).	oxidosqualene	67-80	lupeol synthase 1	Arabidopsis thaliana	21-25
16435854-2	2006	Known lanosterol synthase mutants produce monocyclic or tetracyclic byproducts from oxidosqualene.	oxidosqualene	84-97	lanosterol synthase	Homo sapiens	6-25
12842197-2	2003	The oxidosqualene cyclase (Erg7p) encoded by the ERG7 gene converts oxidosqualene to lanosterol, the first cyclic component of sterol biosynthesis.	oxidosqualene	4-17	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	27-32
12842197-2	2003	The oxidosqualene cyclase (Erg7p) encoded by the ERG7 gene converts oxidosqualene to lanosterol, the first cyclic component of sterol biosynthesis.	oxidosqualene	4-17	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	49-53
12842197-3	2003	In a previous study, we found that erg27 strains grown on cholesterol- or ergosterol-supplemented media did not accumulate lanosterol or 3-ketosterols but rather squalene, oxidosqualene, and dioxidosqualene intermediates normally observed in ERG7 (oxidosqualene cyclase) mutants.	oxidosqualene	172-185	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	35-40
11706015-6	2002	In an erg7 deletion strain or in wild-type cells treated with an inhibitor of oxidosqualene cyclase, the substrate of Erg7p, oxidosqualene, accumulated mostly in lipid particles.	oxidosqualene	78-91	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	6-10
11706015-6	2002	In an erg7 deletion strain or in wild-type cells treated with an inhibitor of oxidosqualene cyclase, the substrate of Erg7p, oxidosqualene, accumulated mostly in lipid particles.	oxidosqualene	78-91	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	118-123
10930257-0	2000	Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol.	oxidosqualene	35-48	lupeol synthase 1	Arabidopsis thaliana	21-25
10930257-1	2000	The Arabidopsis thaliana LUP1 gene encodes an enzyme that converts oxidosqualene to pentacyclic triterpenes.	oxidosqualene	67-80	lupeol synthase 1	Arabidopsis thaliana	25-29
10535978-9	1999	Surprisingly, when erg27 was grown on cholesterol- or ergosterol-supplemented media, the endogenous compounds that accumulated were noncyclic sterol intermediates (squalene, squalene epoxide, and squalene dioxide), and there was little or no accumulation of lanosterol or 3-ketosterols.	oxidosqualene	174-190	3-keto-steroid reductase	Saccharomyces cerevisiae S288C	19-24
8041797-1	1994	The ERG7 gene encoding oxidosqualene-lanosterol cyclase [(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol forming), EC 5.4.99.7] from Saccharomyces cerevisiae has been cloned by genetic complementation of a cyclase-deficient erg7 strain.	oxidosqualene	23-36	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	4-8
8041797-1	1994	The ERG7 gene encoding oxidosqualene-lanosterol cyclase [(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol forming), EC 5.4.99.7] from Saccharomyces cerevisiae has been cloned by genetic complementation of a cyclase-deficient erg7 strain.	oxidosqualene	23-36	lanosterol synthase ERG7	Saccharomyces cerevisiae S288C	228-232
500676-6	1979	The response of microsomal squalene epoxide-lanosterol cyclase to SPF was abolished by pretreatment of the membranes with phospholipase A2 or by low concentrations of deoxycholate, indicating that an intact membrane system is required.	oxidosqualene	27-43	SEC14 like lipid binding 2	Homo sapiens	66-69
500676-6	1979	The response of microsomal squalene epoxide-lanosterol cyclase to SPF was abolished by pretreatment of the membranes with phospholipase A2 or by low concentrations of deoxycholate, indicating that an intact membrane system is required.	oxidosqualene	27-43	phospholipase A2 group IB	Homo sapiens	122-138
26463208-5	2015	By contrast, the defect of plasmalogen synthesis causes elevation of SQLE expression, resulting in the reduction of 2,3-epoxysqualene required for cholesterol synthesis, hence implying a novel physiological consequence of the regulation of plasmalogen biosynthesis.	oxidosqualene	116-133	squalene epoxidase	Homo sapiens	69-73
32101538-2	2020	Lanosterol synthase (LSS) converts (S)-2,3-epoxysqualene to lanosterol in the cholesterol biosynthesis pathway.	oxidosqualene	35-56	lanosterol synthase	Mus musculus	0-19
32101538-2	2020	Lanosterol synthase (LSS) converts (S)-2,3-epoxysqualene to lanosterol in the cholesterol biosynthesis pathway.	oxidosqualene	35-56	lanosterol synthase	Mus musculus	21-24
32101538-6	2020	We showed that the blockade of the LSS enzyme reaction occurred in the patients by measuring the (S)-2,3-epoxysqualene/lanosterol ratio in the forehead sebum, which would be a good biomarker for the diagnosis of LSS deficiency.	oxidosqualene	97-118	lanosterol synthase	Homo sapiens	35-38
32101538-6	2020	We showed that the blockade of the LSS enzyme reaction occurred in the patients by measuring the (S)-2,3-epoxysqualene/lanosterol ratio in the forehead sebum, which would be a good biomarker for the diagnosis of LSS deficiency.	oxidosqualene	97-118	lanosterol synthase	Homo sapiens	212-215