PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
17894348-2	2008	Furthermore, Pro-Pro units are abundant in collagen, in ligand motifs binding to SH3 or WW domains, as well as in vital enzymes such as DNA glycosylase and thrombin.	Pro-Pro	13-20	coagulation factor II, thrombin	Homo sapiens	156-164
19818814-3	2010	By using the fusion expression with unique acid labile linker Asp-Pro and biochemical purification, the three novel GHRH peptides, Pro-Pro-hGHRH(1-44)-Gly-Gly-Cys, Pro-hGHRH(1-44)-Gly-Gly-Cys, and (1)Pro-GHRH(2-44)-Gly-Gly-Cys, were obtained.	Pro-Pro	131-138	growth hormone releasing hormone	Rattus norvegicus	140-144
15525469-11	2004	Pro-Pro-hGHRH (1-44)-Gly-Gly-Cys 0.01, 0.1, and 1 mg/L and Pro-Pro-hGHRH (1-44)OH 0.1 and 1 mg/L stimulated GH release from rat pituitary in a concentration-dependent manner (P<0.05, P<0.01).	Pro-Pro	59-66	growth hormone releasing hormone	Homo sapiens	67-72
15525469-0	2004	Construction and activity of a novel GHRH analog, Pro-Pro-hGHRH(1-44)-Gly-Gly-Cys.	Pro-Pro	50-58	growth hormone releasing hormone	Homo sapiens	37-41
10561591-12	1999	However, in contrast to current knowledge, several Pro-Xaa dipeptides such as Pro-Leu, Pro-Tyr and Pro-Pro are recognized by PEPT1 with appreciable affinities.	Pro-Pro	99-106	solute carrier family 15 member 1	Homo sapiens	125-130
15525469-9	2004	RESULTS: The molecular weight of Pro-Pro-hGHRH (1-44)-Gly-Gly-Cys was 5455.4 kDa which was coincident with the theoretical calculations.	Pro-Pro	33-40	growth hormone releasing hormone	Homo sapiens	41-46
15525469-11	2004	Pro-Pro-hGHRH (1-44)-Gly-Gly-Cys 0.01, 0.1, and 1 mg/L and Pro-Pro-hGHRH (1-44)OH 0.1 and 1 mg/L stimulated GH release from rat pituitary in a concentration-dependent manner (P<0.05, P<0.01).	Pro-Pro	0-7	growth hormone releasing hormone	Homo sapiens	8-13
7765605-4	1994	The enzyme hydrolyzed substrates such as Pro-Pro-Pro-Pro, Pro-Pro-Pro, and Pro-Pro to proline, and cleaved N-terminal amino acids from peptides containing penultimate prolines such as bradykinin and neuropeptide Y.	Pro-Pro	41-48	kininogen 1	Bos taurus	184-194
9586797-12	1998	Prednisolone improves the ulcers, and this compound decreased the fMLP- and OZ-induced superoxide generation and tyrosyl phosphorylation of 45 kDa protein in the patient"s neutrophils after priming by Pro-Pro.	Pro-Pro	201-208	formyl peptide receptor 1	Homo sapiens	66-70
9266484-9	1997	(1992), Nature (London) 356, 248-252] that residues 90-111 of PH-30 alpha may be the fusogenic region and suggest that the Pro-Pro sequence is one of the important factors for holding the active secondary structure of the fusogenic region of PH-30 alpha in membranes.	Pro-Pro	123-130	ADAM metallopeptidase domain 1A (pseudogene)	Homo sapiens	62-73
9738916-7	1998	LMM glutenin containing many Gln-Gln-Gln-Pro-Pro motifs, which was identified to be IgE-binding epitope [Tanabe, S., Arai, S., Yanagihara, Y., Mita, H., Takahashi, K. & Watanabe, M. (1996) Biochem.	Pro-Pro	41-48	stimulator of interferon response cGAMP interactor 1	Homo sapiens	143-147
9056177-5	1997	A comparison with a data base suggested that the sequence is very similar to des-arg9bradykinin (arg-pro-pro-gly-phe-ser-pro-phe).	Pro-Pro	101-108	kininogen 1	Homo sapiens	85-95
7765605-4	1994	The enzyme hydrolyzed substrates such as Pro-Pro-Pro-Pro, Pro-Pro-Pro, and Pro-Pro to proline, and cleaved N-terminal amino acids from peptides containing penultimate prolines such as bradykinin and neuropeptide Y.	Pro-Pro	41-48	neuropeptide Y	Bos taurus	199-213
1885582-7	1991	Enalapril dicarboxylic acid and Glu-Trp-Pro-Arg-ProGln-Ile-Pro-Pro which inhibit angiotensin-converting enzyme: angiotensin I, bradykinin, and N-[3-(2-furyl)acryloyl]Phe-Gly-Gly which are substrates; and chloride ions which activate angiotensin-converting enzyme did not modulate leukotriene A4 hydrolase/aminopeptidase activity.	Pro-Pro	59-66	angiotensinogen	Homo sapiens	112-125
7504274-4	1993	The identified library epitopes shared the consensus sequence Pro-(Pro/Ser)-Gly-His-(Tyr/Phe)-Lys, corresponding to two continuous protein sequences of bFGF: Pro-Pro-Gly-His-Phe-Lys and Arg-Thr-Gly-Gln-Tyr-Lys at amino acids 13-18 and 120-125 of bFGF, respectively.	Pro-Pro	62-70	fibroblast growth factor 2	Homo sapiens	152-156
7918465-1	1994	Synthesis of the boronic acid analog of the dipeptide Pro-Pro yields a mixture of diastereomers Pro-L-boroPro and Pro-D-boroPro, one of which is a potent inhibitor [Ki = 16 pM; Gutheil, W. G., & Bachovchin, W. W. (1993) Biochemistry 32, 8723-8731] of dipeptidyl amino peptidase type IV (DP IV), also known as CD26.	Pro-Pro	54-61	dipeptidyl peptidase 4	Homo sapiens	313-317
1885582-7	1991	Enalapril dicarboxylic acid and Glu-Trp-Pro-Arg-ProGln-Ile-Pro-Pro which inhibit angiotensin-converting enzyme: angiotensin I, bradykinin, and N-[3-(2-furyl)acryloyl]Phe-Gly-Gly which are substrates; and chloride ions which activate angiotensin-converting enzyme did not modulate leukotriene A4 hydrolase/aminopeptidase activity.	Pro-Pro	59-66	kininogen 1	Homo sapiens	127-137
1885582-7	1991	Enalapril dicarboxylic acid and Glu-Trp-Pro-Arg-ProGln-Ile-Pro-Pro which inhibit angiotensin-converting enzyme: angiotensin I, bradykinin, and N-[3-(2-furyl)acryloyl]Phe-Gly-Gly which are substrates; and chloride ions which activate angiotensin-converting enzyme did not modulate leukotriene A4 hydrolase/aminopeptidase activity.	Pro-Pro	59-66	leukotriene A4 hydrolase	Homo sapiens	280-304
1885582-7	1991	Enalapril dicarboxylic acid and Glu-Trp-Pro-Arg-ProGln-Ile-Pro-Pro which inhibit angiotensin-converting enzyme: angiotensin I, bradykinin, and N-[3-(2-furyl)acryloyl]Phe-Gly-Gly which are substrates; and chloride ions which activate angiotensin-converting enzyme did not modulate leukotriene A4 hydrolase/aminopeptidase activity.	Pro-Pro	59-66	carboxypeptidase Q	Homo sapiens	305-319
33069067-5	2020	Multidimensional NMR spectroscopic and circular dichroism analyses revealed that the cyclic CPP as well as the Grb2 SH2 inhibitor assume a predominantly random coil structure but have significant beta-hairpin character surrounding the d-Pro-l-Pro motif.	Pro-Pro	235-246	growth factor receptor bound protein 2	Homo sapiens	111-115
7228251-6	1980	Cyclo-(Pro-Pro-) yielded NPYR at pH 5.7 and 4.0, as well.	Pro-Pro	7-15	neuropeptide Y receptor Y1	Homo sapiens	25-29
31988201-5	2021	Pro- (e.g., corticotropin-releasing factor [CRF]) and antistress (e.g., nociceptin/orphanin FQ, oxytocin) neuropeptides affect alcohol- and anxiety-related behaviors, and also alter the alcohol-induced effects on CeA neurotransmission.	Pro-Pro	0-3	CEA cell adhesion molecule 3	Homo sapiens	213-216
31926033-1	2021	We have previously shown that treatment with a mGluR5 positive allosteric modulator (PAM) is neuroprotective after experimental traumatic brain injury (TBI), limiting post-traumatic neuroinflammation by reducing pro-inflammatory microglial activation and promoting anti-inflammatory and neuroprotective responses.	Pro-Pro	98-101	glutamate receptor, ionotropic, kainate 1	Mus musculus	47-53
31926033-8	2021	Taken together, our data show that VuPAM decreases pro-inflammatory microglial activation by modulating Akt/GSK-3beta/CREB signaling.	Pro-Pro	51-54	thymoma viral proto-oncogene 1	Mus musculus	104-107
31926033-8	2021	Taken together, our data show that VuPAM decreases pro-inflammatory microglial activation by modulating Akt/GSK-3beta/CREB signaling.	Pro-Pro	51-54	glycogen synthase kinase 3 beta	Mus musculus	108-117
31926033-8	2021	Taken together, our data show that VuPAM decreases pro-inflammatory microglial activation by modulating Akt/GSK-3beta/CREB signaling.	Pro-Pro	51-54	cAMP responsive element binding protein 1	Mus musculus	118-122
31665242-0	2019	Decreased microglial Wnt/beta-catenin signalling drives microglial pro-inflammatory activation in the developing brain.	Pro-Pro	67-70	catenin beta 1	Homo sapiens	25-37
32375038-5	2020	The electrostatic interaction between the charged nascent chain and the ribosome exit tunnel determines the eIF5A-mediated disome rescue at the Pro-Pro sites.	Pro-Pro	144-151	eukaryotic translation initiation factor 5A	Homo sapiens	108-113
31560043-7	2020	RESULTS: Pro-inflammatory costimulation with GM-CSF/IFNgamma resulted in significant tumor necrosis factor (TNFalpha) and interleukin (IL)-6 increase, whereas IL-10 expression decreased in monocytes.	Pro-Pro	9-12	colony stimulating factor 2	Homo sapiens	45-51
31560043-7	2020	RESULTS: Pro-inflammatory costimulation with GM-CSF/IFNgamma resulted in significant tumor necrosis factor (TNFalpha) and interleukin (IL)-6 increase, whereas IL-10 expression decreased in monocytes.	Pro-Pro	9-12	tumor necrosis factor	Homo sapiens	108-116
26342756-13	2015	In diabetes, increased MMP9 activities seem to favour the production of Ala-Pro and Pro-Pro containing collagen fragments.	Pro-Pro	84-91	matrix metallopeptidase 9	Rattus norvegicus	23-27
31775224-3	2019	Results showed that these amphiphilic peptides demonstrated antimicrobial activity in a size-dependent manner and that cyclic peptide OIR3, which contained three repeating units (IR)3, had greater antimicrobial potency and cell selectivity than liner peptide IR3, DIR3 with D-Pro and gramicidin S (GS).	Pro-Pro	274-279	immune response 3	Mus musculus	135-138
24375191-7	2014	Subgroup analysis by race showed that TP53 Arg72Pro polymorphism was associated with thyroid carcinoma in Caucasians (ProPro vs. ArgArg/ArgPro, OR = 2.31, 95% CI 1.08 to 4.93, P = 0.03).	Pro-Pro	118-124	tumor protein p53	Homo sapiens	38-42
23628797-7	2013	Genotype frequencies of PLAU Pro141Leu (rs2227564) were 59.1% for ProPro, 35.6% for ProLeu, and 5.3% for LeuLeu, and were in Hardy-Weinberg equilibrium (p=0.789).	Pro-Pro	66-72	plasminogen activator, urokinase	Homo sapiens	24-28
23628797-9	2013	The multivariate-adjusted odd ratios (ORs) and 95% confidence intervals (CIs) for high LDL-C and non-HDL-C were 1.11 (95%CI; 1.00-1.23) and 1.16 (95%CI; 1.03-1.30) for those with Leu allele relative to ProPro.	Pro-Pro	202-208	component of oligomeric golgi complex 2	Homo sapiens	87-92
23184052-7	2013	Subgroup analyses by ethnicity showed that TP53 Arg72Pro polymorphism contributed to bladder cancer risk in East Asians in three genetic models (For Pro vs. Arg, Fixed-effects OR 1.18, 95 % CI 1.05-1.32; For ProPro vs. ArgArg, Fixed-effects OR 1.40, 95 % CI 1.11-1.77; For ProPro vs. ArgPro/ArgArg, Fixed-effects OR 1.32, 95 % CI 1.07-1.62).	Pro-Pro	208-214	tumor protein p53	Homo sapiens	43-47
23184052-7	2013	Subgroup analyses by ethnicity showed that TP53 Arg72Pro polymorphism contributed to bladder cancer risk in East Asians in three genetic models (For Pro vs. Arg, Fixed-effects OR 1.18, 95 % CI 1.05-1.32; For ProPro vs. ArgArg, Fixed-effects OR 1.40, 95 % CI 1.11-1.77; For ProPro vs. ArgPro/ArgArg, Fixed-effects OR 1.32, 95 % CI 1.07-1.62).	Pro-Pro	273-279	tumor protein p53	Homo sapiens	43-47
21221598-1	2011	Milk casein-derived tripeptides, valyl prolyl proline (VPP), and isoleucyl prolyl proline (IPP) inhibit angiotensin-converting enzyme (ACE) and both fermented milk and proteolytic hydrolysates of milk casein containing these peptides exert blood pressure-lowering effects in animals and humans.	Pro-Pro	39-53	angiotensin I converting enzyme	Homo sapiens	104-133
21221598-1	2011	Milk casein-derived tripeptides, valyl prolyl proline (VPP), and isoleucyl prolyl proline (IPP) inhibit angiotensin-converting enzyme (ACE) and both fermented milk and proteolytic hydrolysates of milk casein containing these peptides exert blood pressure-lowering effects in animals and humans.	Pro-Pro	39-53	angiotensin I converting enzyme	Homo sapiens	135-138