PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25845343-0	2015	Phosphate and thiophosphate biphenyl analogs as steroid sulfatase inhibitors.	thiophosphoric acid	14-27	steroid sulfatase	Homo sapiens	48-65
25918412-6	2015	Thiophosphate is bound to a site in the alpha(E)beta(E)-catalytic interface, whereas in F1-ATPase inhibited with IF1, the equivalent site is changed subtly and the enzyme is incapable of binding thiophosphate.	thiophosphoric acid	195-208	ATP synthase inhibitory factor subunit 1	Homo sapiens	113-116
25845343-1	2015	In the present work, we report convenient methods for the synthesis and biological evaluation of phosphate and thiophosphate biphenyl derivatives exhibiting steroid sulfatase (STS) activity.	thiophosphoric acid	111-124	steroid sulfatase	Homo sapiens	157-174
26269086-0	2015	Synthesis and biological evaluation of thiophosphate tricyclic coumarin derivatives as steroid sulfatase inhibitors.	thiophosphoric acid	39-52	steroid sulfatase	Homo sapiens	87-104
26088349-6	2015	The greatest potency for VEGF release and stimulation of cell migration by thiophosphate analogues of ATP and UTP correlates with the highest P2Y2 receptor expression by HaCaT cells.	thiophosphoric acid	75-88	vascular endothelial growth factor A	Homo sapiens	25-29
22784015-0	2012	Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: effects related to activity and Sec contents of thioredoxin reductase.	thiophosphoric acid	0-13	peroxiredoxin 2	Mus musculus	153-174
25326317-9	2014	Based on these findings, we proposed a simple model wherein SelD-like may play an important role in the biosynthesis of certain thiophosphate compound.	thiophosphoric acid	128-141	selenophosphate synthetase 1	Homo sapiens	60-64
21115847-2	2010	Herein, we show that supplementation of mammalian cells with thiophosphate led to targeted insertion of Cys at the UGA codon of thioredoxin reductase 1 (TR1).	thiophosphoric acid	61-74	thioredoxin reductase 1	Homo sapiens	128-151
22332041-6	2011	Interestingly, sulfide can replace selenide to form thiophosphate in the SPS2-catalyzed reaction that can then react with O-phosphoseryl-tRNA([Ser]Sec) in the presence of SecS to form cysteine-(Cys-)tRNA([Ser]Sec).	thiophosphoric acid	52-65	selenophosphate synthetase 2	Mus musculus	73-77
22332041-6	2011	Interestingly, sulfide can replace selenide to form thiophosphate in the SPS2-catalyzed reaction that can then react with O-phosphoseryl-tRNA([Ser]Sec) in the presence of SecS to form cysteine-(Cys-)tRNA([Ser]Sec).	thiophosphoric acid	52-65	eukaryotic elongation factor, selenocysteine-tRNA-specific	Mus musculus	147-150
22332041-6	2011	Interestingly, sulfide can replace selenide to form thiophosphate in the SPS2-catalyzed reaction that can then react with O-phosphoseryl-tRNA([Ser]Sec) in the presence of SecS to form cysteine-(Cys-)tRNA([Ser]Sec).	thiophosphoric acid	52-65	Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase	Mus musculus	171-175
22332041-6	2011	Interestingly, sulfide can replace selenide to form thiophosphate in the SPS2-catalyzed reaction that can then react with O-phosphoseryl-tRNA([Ser]Sec) in the presence of SecS to form cysteine-(Cys-)tRNA([Ser]Sec).	thiophosphoric acid	52-65	eukaryotic elongation factor, selenocysteine-tRNA-specific	Mus musculus	171-174
21115847-2	2010	Herein, we show that supplementation of mammalian cells with thiophosphate led to targeted insertion of Cys at the UGA codon of thioredoxin reductase 1 (TR1).	thiophosphoric acid	61-74	thioredoxin reductase 1	Homo sapiens	153-156
21115847-4	2010	The substrate for this reaction, thiophosphate, was synthesized by selenophosphate synthetase 2 from ATP and sulfide and reacted with phosphoseryl-tRNA([Ser]Sec) to generate Cys-tRNA([Ser]Sec).	thiophosphoric acid	33-46	selenophosphate synthetase 2	Homo sapiens	67-95
21115847-4	2010	The substrate for this reaction, thiophosphate, was synthesized by selenophosphate synthetase 2 from ATP and sulfide and reacted with phosphoseryl-tRNA([Ser]Sec) to generate Cys-tRNA([Ser]Sec).	thiophosphoric acid	33-46	eukaryotic elongation factor, selenocysteine-tRNA-specific	Mus musculus	157-160
21115847-4	2010	The substrate for this reaction, thiophosphate, was synthesized by selenophosphate synthetase 2 from ATP and sulfide and reacted with phosphoseryl-tRNA([Ser]Sec) to generate Cys-tRNA([Ser]Sec).	thiophosphoric acid	33-46	eukaryotic elongation factor, selenocysteine-tRNA-specific	Mus musculus	188-191
21115847-7	2010	These data reveal a novel Sec machinery-based mechanism for biosynthesis and insertion of Cys into protein at UGA codons and suggest new biological functions for thiophosphate and sulfide in mammals.	thiophosphoric acid	162-175	eukaryotic elongation factor, selenocysteine-tRNA-specific	Mus musculus	26-29
20183589-0	2009	Thiophosphate analogs of c-di-GMP: impact on polymorphism.	thiophosphoric acid	0-13	5'-nucleotidase, cytosolic II	Homo sapiens	30-33
20927342-4	2010	In this study, we identified a thiophosphate modified aptamer (thioaptamer, TA) against E-selectin (ESTA-1) by employing a two-step selection strategy: a recombinant protein-based TA binding selection from a combinatorial library followed by a cell-based TA binding selection using E-selectin expressing human microvascular endothelial cells.	thiophosphoric acid	31-44	selectin E	Homo sapiens	88-98
20927342-4	2010	In this study, we identified a thiophosphate modified aptamer (thioaptamer, TA) against E-selectin (ESTA-1) by employing a two-step selection strategy: a recombinant protein-based TA binding selection from a combinatorial library followed by a cell-based TA binding selection using E-selectin expressing human microvascular endothelial cells.	thiophosphoric acid	31-44	selectin E	Homo sapiens	282-292
18202915-4	2008	The water samples were treated with chlorine to enhance the ChE-inhibiting activity by conversion of thiophosphate pesticides to phosphate pesticides.	thiophosphoric acid	101-114	butyrylcholinesterase	Homo sapiens	60-63
18847512-10	2008	CONCLUSIONS: We used methods entailing engineered kinases and thiophosphate enrichment to identify a large number of candidate CDK2 substrates in cell lysates.	thiophosphoric acid	62-75	cyclin dependent kinase 2	Homo sapiens	127-131
11835749-2	2002	METHODS: Various concentrations of HOXB2 asodn modified by thiophosphate transfected the induction of liposome into HUVECs.	thiophosphoric acid	59-72	homeobox B2	Homo sapiens	35-40
18043798-4	2007	The large rho(X) (rho(nuc) = -3.1 to -3.4) and beta(X) (beta(nuc) = 1.1-1.2) values seem to be characteristic of the anilinolysis of phosphates and thiophosphates with the Cl leaving group.	thiophosphoric acid	148-162	rhodopsin	Homo sapiens	10-31
15177455-4	2004	Additionally, thiophosphate 19 bears an isosteric phosphate mimetic that confers agonism at the LPA1 receptor but not LPA2.	thiophosphoric acid	14-27	lysophosphatidic acid receptor 1	Homo sapiens	96-100
11926992-6	2002	Treatment of fibronectin-unstimulated and stimulated macrophages with thiophosphate, which forms thiophosphate esters of intracellular proteins that are not so susceptible to protein phosphatases, enhanced macrophage binding of oxLDL.	thiophosphoric acid	70-83	fibronectin 1	Mus musculus	13-24
9871707-0	1998	A thiophosphate analog of dimyristoylphosphatidyl-inositol-4-phosphate is a substrate for mammalian phosphoinositide-specific phospholipase C. 1,2-Dimyristoyloxypropane-3-thiophosphate(rac-1-myo-inositol-4- phosphate), a thiophosphate analog of dimyristoyl phosphatidylinositol-4-phosphate was synthesized as a substrate for mammalian phosphoinositide-specific phospholipase C. Its activity with delta(1-132)-PI-PLC-delta 1 (a deletion mutant with the N-terminal pleckstrin homology domain removed) was studied in sonicated dispersions, with and without added Triton X-100.	thiophosphoric acid	2-15	Rac family small GTPase 1	Homo sapiens	185-190
10234440-6	1999	We suggested the presence of an electrophilic region in the active site of ACE, which can interact with the ethoxycarbonyl group of the thiophosphates under study.	thiophosphoric acid	136-150	acetylcholinesterase	Mus musculus	75-78
11859612-2	2001	METHODS: Various concentrations of HOXB2 ASODN modified by thiophosphate were transfected into HUVECs by liposome mediation.	thiophosphoric acid	59-72	homeobox B2	Homo sapiens	35-40
9488696-7	1998	NDK also catalyzes the transfer of thiophosphate from adenosine 5"-O-(thiotriphosphate) (ATPgammaS) and guanosine 5"-O-(thiotriphosphate) (GTPgammaS) to NDP, but at (1)/(1000) of the equivalent phosphoryl transfer rates.	thiophosphoric acid	35-48	NME/NM23 nucleoside diphosphate kinase 4	Homo sapiens	0-3
1325744-2	1992	Sp-cAMP, a thiophosphate analogue of c-AMP, is a phosphodiesterase inhibitor controlling the intracellular c-AMP levels which in turn influences sperm motility.	thiophosphoric acid	11-24	cathelicidin antimicrobial peptide	Homo sapiens	37-42
9305951-11	1997	Interestingly, the thiophosphate group is evident in S1dC.MgATPgammaS even though it is slowly hydrolyzed by myosin.	thiophosphoric acid	19-32	myosin, heavy chain 10, non-muscle	Gallus gallus	109-115
1325744-2	1992	Sp-cAMP, a thiophosphate analogue of c-AMP, is a phosphodiesterase inhibitor controlling the intracellular c-AMP levels which in turn influences sperm motility.	thiophosphoric acid	11-24	cathelicidin antimicrobial peptide	Homo sapiens	107-112
2985044-9	1985	The thiophosphate analogues of ADP all inhibit 5"-nucleotidase, although not as powerfully as ADP, the most effective of these analogues being adenosine 5"-O-(1-thiodiphosphate) diastereoisomer B (ADP[alpha S](B)].	thiophosphoric acid	4-17	5' nucleotidase, ecto	Rattus norvegicus	47-62
1657144-5	1991	The complexes MgMTP2-, CoMTP2-, and MnMTP2- undergo hydrolytic cleavage with release of thiophosphate with observed first-order rate constants of 1.6 x 10(-2) min-1, 2.3 x 10(-2) min-1, and 0.6 x 10(-2) min-1, respectively, at 35 degrees C, compared with 1.1 x 10(-2) min-1 for MTP4- under the same conditions.	thiophosphoric acid	88-101	CD59 molecule (CD59 blood group)	Homo sapiens	159-164
1657144-5	1991	The complexes MgMTP2-, CoMTP2-, and MnMTP2- undergo hydrolytic cleavage with release of thiophosphate with observed first-order rate constants of 1.6 x 10(-2) min-1, 2.3 x 10(-2) min-1, and 0.6 x 10(-2) min-1, respectively, at 35 degrees C, compared with 1.1 x 10(-2) min-1 for MTP4- under the same conditions.	thiophosphoric acid	88-101	CD59 molecule (CD59 blood group)	Homo sapiens	179-184
1657144-5	1991	The complexes MgMTP2-, CoMTP2-, and MnMTP2- undergo hydrolytic cleavage with release of thiophosphate with observed first-order rate constants of 1.6 x 10(-2) min-1, 2.3 x 10(-2) min-1, and 0.6 x 10(-2) min-1, respectively, at 35 degrees C, compared with 1.1 x 10(-2) min-1 for MTP4- under the same conditions.	thiophosphoric acid	88-101	CD59 molecule (CD59 blood group)	Homo sapiens	179-184
1657144-5	1991	The complexes MgMTP2-, CoMTP2-, and MnMTP2- undergo hydrolytic cleavage with release of thiophosphate with observed first-order rate constants of 1.6 x 10(-2) min-1, 2.3 x 10(-2) min-1, and 0.6 x 10(-2) min-1, respectively, at 35 degrees C, compared with 1.1 x 10(-2) min-1 for MTP4- under the same conditions.	thiophosphoric acid	88-101	CD59 molecule (CD59 blood group)	Homo sapiens	179-184
1646810-3	1991	When CaM-kinase II was incubated with adenosine 5"-O-(thiotriphosphate) at 5 degrees C, the incorporation of thiophosphate into the enzyme occurred rapidly, reaching a maximum level within a few minutes, in parallel with increase in Ca2+/CaM-independent activity.	thiophosphoric acid	109-122	calmodulin 3	Homo sapiens	5-8
1646810-3	1991	When CaM-kinase II was incubated with adenosine 5"-O-(thiotriphosphate) at 5 degrees C, the incorporation of thiophosphate into the enzyme occurred rapidly, reaching a maximum level within a few minutes, in parallel with increase in Ca2+/CaM-independent activity.	thiophosphoric acid	109-122	calmodulin 3	Homo sapiens	238-241
2549876-7	1989	Finally, sodium thiophosphate, but not sodium phosphate, markedly stimulated 5-lipoxygenase activity with properties similar to those of GTP gamma S. These results indicate that GTP gamma S and other phosphorothioate derivatives have redox properties that can contribute to increase 5-lipoxygenase activity by replacing the effect of hydroperoxides.	thiophosphoric acid	9-29	arachidonate 5-lipoxygenase	Rattus norvegicus	77-91
2549876-7	1989	Finally, sodium thiophosphate, but not sodium phosphate, markedly stimulated 5-lipoxygenase activity with properties similar to those of GTP gamma S. These results indicate that GTP gamma S and other phosphorothioate derivatives have redox properties that can contribute to increase 5-lipoxygenase activity by replacing the effect of hydroperoxides.	thiophosphoric acid	9-29	arachidonate 5-lipoxygenase	Rattus norvegicus	283-297
3257964-5	1988	Thiophosphorylation of LC20 by adenosine 5"-O-(thiotriphosphate) resulted in the incorporation of 1 mol of thiophosphate into phosphoserine.	thiophosphoric acid	107-120	myosin light chain 9	Homo sapiens	23-27
3794990-5	1986	In an in vitro study, an inhibition of hepatic microsomal metabolism of BPMC and a decrease of cytochrome P-450 content by thiophosphates were observed at the concentration of 10 microM, but not by 25 microM of oxon.	thiophosphoric acid	123-137	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	95-111
3794990-7	1986	Cytochrome P-450 content was decreased by the thiophosphates in doses of 4/10 of their LD50"s, but not by the oxon.	thiophosphoric acid	46-60	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	0-16
3000652-1	1985	WR-2721 is an organic thiophosphate, known as a radioprotective agent, which also inhibits parathyroid hormone (PTH) secretion and reduces the plasma calcium level in euparathyroid animals and human subjects.	thiophosphoric acid	22-35	parathyroid hormone	Homo sapiens	91-110
1657618-7	1991	Finally, regulation of [3H]FMLP binding by ATP[S] plus GDP (or GTP) was a time-dependent process, reaching maximal inhibition after 20-30 min of incubation at 25 degrees C. The data indicate that nucleoside diphosphokinase present in membranes of HL 60 cells can transfer the thiophosphate group of ATP[S] to GDP leading to formation of GTP[S] and that the GTP[S] thus formed efficiently binds to G proteins interacting with formyl peptide receptors and thereby regulates their agonist binding affinity.	thiophosphoric acid	276-289	formyl peptide receptor 1	Homo sapiens	27-31
2140360-4	1990	In contrast, the relationship between isometric force and myosin light-chain thiophosphorylation was linear, with maximum force occurring at 1.0 mol of thiophosphate/mol of myosin light chain.	thiophosphoric acid	152-165	myosin, heavy chain 15	Gallus gallus	58-64
2140360-4	1990	In contrast, the relationship between isometric force and myosin light-chain thiophosphorylation was linear, with maximum force occurring at 1.0 mol of thiophosphate/mol of myosin light chain.	thiophosphoric acid	152-165	myosin, heavy chain 15	Gallus gallus	173-179
2265588-0	1990	[The role of cytochrome P-450 in detoxifying the thioethynyl esters of monothiophosphoric acids].	thiophosphoric acid	71-95	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	13-29
34716655-1	2022	A promising anode material consisting of bimetallic thiophosphate Znx Co1- x PS3 and CoS2 with 2D/3D heterostructure is designed and prepared by an effective chemical transformation.	thiophosphoric acid	52-65	taste 2 receptor member 6 pseudogene	Homo sapiens	77-80
880303-2	1977	The method involves the thiophosphate exchange of adenosine 5"-O-(3-thiotriphosphate) with [35S]thiophosphate with the aid of glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate kinase in the presence of 3-phosphoglycerate.	thiophosphoric acid	96-109	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	126-166
456606-0	1979	The preparation of thiophosphate analogs of GDP and their interaction with EF-Tu.	thiophosphoric acid	19-32	Tu translation elongation factor, mitochondrial	Homo sapiens	75-80
6101943-0	1980	Stereochemistry of binding of thiophosphate analogs of ATP and ADP to carbamate kinase, glutamine synthetase, and carbamoyl-phosphate synthetase.	thiophosphoric acid	30-43	ATPase phospholipid transporting 8A2	Homo sapiens	55-86
6101943-0	1980	Stereochemistry of binding of thiophosphate analogs of ATP and ADP to carbamate kinase, glutamine synthetase, and carbamoyl-phosphate synthetase.	thiophosphoric acid	30-43	glutamate-ammonia ligase	Homo sapiens	88-108
4803471-0	1973	[Hydrolysis of thiophosphate analogs of ATP by myosin fragment S1].	thiophosphoric acid	15-28	myosin heavy chain 14	Homo sapiens	47-53
33439620-12	2021	Our observations broaden the understanding of thiophosphate biochemistry and enable the rational design of translationally active mRNAs and eIF4E-targeting drugs.	thiophosphoric acid	46-59	eukaryotic translation initiation factor 4E	Homo sapiens	140-145
33485193-6	2021	The effect of IMPy and DETP on DHEAS and TT levels, respectively, was higher in subjects that carried the PON1 55MM genotype, while the effect of TCPy, IMPy, and DETP on thyroid hormone levels was higher in PON1 192QR/RR or 55MM genotype carriers.	thiophosphoric acid	23-27	paraoxonase 1	Homo sapiens	106-110
26452064-6	2015	Treatment of cells expressing SelP with thiophosphate, an analog of the selenium donor for Sec synthesis, led to a nearly complete replacement of Sec with Cys, whereas supplementation of cells with selenium supported Sec insertion.	thiophosphoric acid	40-53	selenoprotein P	Homo sapiens	30-34
32159561-1	2020	Four bimetallic phases of the thiophosphate family have been synthesized by the cationic exchange reaction using a freshly prepared K0.5Cd0.75PS3 precursor phase and methanolic solutions of nitrates of the divalent cations ZnII, NiII, CoII, and MnII.	thiophosphoric acid	30-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	235-239
27983831-0	2017	Phase Transition and Second Harmonic Generation in Thiophosphates Ag2Cd(P2S6) and AgCd3(PS4)S2 Containing Two Second-Order Jahn-Teller Distorted Cations.	thiophosphoric acid	51-65	taste 2 receptor member 18 pseudogene	Homo sapiens	88-91
30702788-0	2019	Ionic Conductivity of the NASICON-Related Thiophosphate Na1+x Ti2-x Gax (PS4 )3.	thiophosphoric acid	42-55	mesenchyme homeobox 2	Homo sapiens	68-71
30702788-0	2019	Ionic Conductivity of the NASICON-Related Thiophosphate Na1+x Ti2-x Gax (PS4 )3.	thiophosphoric acid	42-55	taste 2 receptor member 18 pseudogene	Homo sapiens	73-76
28369648-4	2017	P450 enzymes metabolize chlorpyrifos to chlorpyrifos-oxon, which is then metabolized primarily to 3, 5, 6-trichloropyridinol in addition to diethylphosphate and diethylthiophosphate.	thiophosphoric acid	161-181	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	0-4
28067494-3	2017	These new thiophosphates crystallize in four different structure types, with the space groups Fdd2, P1, P21, and P21/c, respectively.	thiophosphoric acid	10-24	H3 histone pseudogene 16	Homo sapiens	104-107
28067494-3	2017	These new thiophosphates crystallize in four different structure types, with the space groups Fdd2, P1, P21, and P21/c, respectively.	thiophosphoric acid	10-24	H3 histone pseudogene 16	Homo sapiens	113-118
26432195-3	2016	Alkaline phosphatase (ALP) catalyzes the hydrolisis of sodium thiophosphate (TP) to hydrogen sulfide (H2S) which in the presence Cd(2+) ions yields CdS semiconductor nanoparticles (SNPs).	thiophosphoric acid	55-75	alkaline phosphatase, placental	Homo sapiens	0-20
26432195-3	2016	Alkaline phosphatase (ALP) catalyzes the hydrolisis of sodium thiophosphate (TP) to hydrogen sulfide (H2S) which in the presence Cd(2+) ions yields CdS semiconductor nanoparticles (SNPs).	thiophosphoric acid	55-75	alkaline phosphatase, placental	Homo sapiens	22-25
26432195-3	2016	Alkaline phosphatase (ALP) catalyzes the hydrolisis of sodium thiophosphate (TP) to hydrogen sulfide (H2S) which in the presence Cd(2+) ions yields CdS semiconductor nanoparticles (SNPs).	thiophosphoric acid	77-79	alkaline phosphatase, placental	Homo sapiens	0-20
26432195-3	2016	Alkaline phosphatase (ALP) catalyzes the hydrolisis of sodium thiophosphate (TP) to hydrogen sulfide (H2S) which in the presence Cd(2+) ions yields CdS semiconductor nanoparticles (SNPs).	thiophosphoric acid	77-79	alkaline phosphatase, placental	Homo sapiens	22-25