PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30287339-11	2019	Notably, we identified a network of key heme biosynthesis enzymes that are suppressed in the absence of beta-catenin, preventing accumulation of toxic protoporphyrins.	Protoporphyrins	151-166	catenin (cadherin associated protein), beta 1	Mus musculus	104-116
7354807-3	1980	We measured the activities of protoporphyrinogen oxidase, which catalyzes the oxidation of protoporphyrinogen to protoporphyrin, and heme synthase, which catalyzes the chelation of iron to protoporphyrins, in cultured skin fibroblasts from five normal controls and five patients with variegate porphyria.	Protoporphyrins	189-204	ferrochelatase	Homo sapiens	133-146
299236-7	1979	The low activity of FCH we measured in our study could be a reason for the elevation of free protoporphyrin in the erythrocytes.	Protoporphyrins	93-107	ferrochelatase	Homo sapiens	20-23
31545517-4	2020	Using human breast, prostate, and brain cancer cell lines, we have shown that iNOS is dramatically upregulated after a moderate PDT challenge sensitized by 5-aminilevulinic acid (ALA)-induced protoporphyrin IX.	Protoporphyrins	192-206	nitric oxide synthase 2	Homo sapiens	78-82
31544812-0	2019	Binding of Immunoglobulin G to Protoporphyrin IX and Its Derivatives: Evidence the Fab Domain Recognizes the Protoporphyrin Ring.	Protoporphyrins	31-45	FA complementation group B	Homo sapiens	83-86
26670809-2	2015	Protoporphyrins are molecules recognized for their modulatory effect on HO-1 expression and function.	Protoporphyrins	0-15	heme oxygenase 1	Mus musculus	72-76
30591946-2	2019	The present work provides additional data on induction and immunolocalization of heme oxygenase (HO)-1 (an antioxidant enzyme) and decay-accelerating factor (DAF) (a complement activation inhibitor) in isolated rat glomeruli and in glomerular epithelial cells (podocytes) in response to Iron Protoporphyrin IX (FePP, heme), and to non-iron protoporphyrins (PPs) with varying metal functionalities (ZnPP, SnPP), including a metal-devoid PP.	Protoporphyrins	357-360	heme oxygenase 1	Rattus norvegicus	81-102
30591946-2	2019	The present work provides additional data on induction and immunolocalization of heme oxygenase (HO)-1 (an antioxidant enzyme) and decay-accelerating factor (DAF) (a complement activation inhibitor) in isolated rat glomeruli and in glomerular epithelial cells (podocytes) in response to Iron Protoporphyrin IX (FePP, heme), and to non-iron protoporphyrins (PPs) with varying metal functionalities (ZnPP, SnPP), including a metal-devoid PP.	Protoporphyrins	357-360	CD55 molecule (Cromer blood group)	Rattus norvegicus	158-161
23348515-2	2013	Previously, two exon 11 small deletions, c.1699_1670DeltaAT (DeltaAT) and c.1706_1709DeltaAGTG (DeltaAGTG), that prematurely truncated or elongated the ALAS2 polypeptide, were reported to increase enzymatic activity 20- to 40-fold, causing the erythroid accumulation of protoporphyrins, cutaneous photosensitivity and liver disease.	Protoporphyrins	270-285	5'-aminolevulinate synthase 2	Homo sapiens	152-157
25506911-0	2014	Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease.	Protoporphyrins	0-15	HtrA serine peptidase 1	Homo sapiens	66-71
25506911-0	2014	Protoporphyrins enhance oligomerization and enzymatic activity of HtrA1 serine protease.	Protoporphyrins	0-15	coagulation factor II, thrombin	Homo sapiens	72-87
15881418-4	2005	We tested the effect of the use of protoporphyrins (CoPP and FePP), powerful inducers of the cytoprotective protein heme-oxygenase 1 (HO-1), on allogeneic islet graft survival.	Protoporphyrins	35-50	heme oxygenase 1	Homo sapiens	116-132
22971305-2	2012	A deficient ferrochelatase enzyme leads to accumulation of protoporphyrins in the dermis, causing phototoxic burning.	Protoporphyrins	59-74	ferrochelatase	Homo sapiens	12-26
18344023-0	2008	Inhibition of plasminogen activator inhibitor-1 expression in vascular smooth muscle cells by protoporphyrins through a heme oxygenase-independent mechanism.	Protoporphyrins	94-109	serpin family E member 1	Homo sapiens	14-47
18344023-2	2008	Accordingly, we examined the effect of protoporphyrins, both HO inhibitors and activators, on PAI-1 expression in human vascular smooth muscle cells (VSMCs).	Protoporphyrins	39-54	serpin family E member 1	Homo sapiens	94-99
18344023-10	2008	Our results demonstrate that protoporphyrins can block the TGFbeta1-mediated induction of PAI-1 protein in VSMCs and that this inhibitory effect is independent of HO activity.	Protoporphyrins	29-44	transforming growth factor beta 1	Homo sapiens	59-67
18344023-10	2008	Our results demonstrate that protoporphyrins can block the TGFbeta1-mediated induction of PAI-1 protein in VSMCs and that this inhibitory effect is independent of HO activity.	Protoporphyrins	29-44	serpin family E member 1	Homo sapiens	90-95
16554028-2	2006	BCRP also protects against phototoxicity by mediating the efflux of protoporphyrins from cells.	Protoporphyrins	68-83	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	0-4
15881418-4	2005	We tested the effect of the use of protoporphyrins (CoPP and FePP), powerful inducers of the cytoprotective protein heme-oxygenase 1 (HO-1), on allogeneic islet graft survival.	Protoporphyrins	35-50	heme oxygenase 1	Homo sapiens	134-138
15881418-12	2005	Administration of protoporphyrins to the recipients of allogeneic islets also resulted in transient powerful immunosuppression with reduced lymphocyte proliferative responses, increased proportion of regulatory cells (CD4+CD25+), decreased mononuclear cell infiltrating the graft, paralleled by a systemic upregulation of HO-1 expression.	Protoporphyrins	18-33	heme oxygenase 1	Homo sapiens	322-326
12673348-0	2003	Effects of protoporphyrins on production of nitric oxide and expression of vascular endothelial growth factor in vascular smooth muscle cells and macrophages.	Protoporphyrins	11-26	vascular endothelial growth factor A	Mus musculus	75-109
12673348-7	2003	The inhibitory potentials of both protoporphyrins on VEGF synthesis were very similar.	Protoporphyrins	34-49	vascular endothelial growth factor A	Mus musculus	53-57
7562835-1	1995	Erythropoietic protoporphyria is an inherited disorder of porphyrin metabolism, in which reduced activity of the enzyme ferrochelatase leads to accumulation of protoporphyrins in erythrocytes.	Protoporphyrins	160-175	ferrochelatase	Homo sapiens	120-134
11522663-7	2001	HO-1 upregulation was induced reproducibly with protoporphyrins and was correlated with protection from apoptosis induced in vitro with proinflammatory cytokines or Fas engagement.	Protoporphyrins	48-63	heme oxygenase 1	Mus musculus	0-4
9931224-6	1999	Free erythrocyte protoporphyrins in blood were associated with Pb-P (r=0.75; P=0.0001) and Pb-B (r=0.90; P=0.0001).	Protoporphyrins	17-32	mediator complex subunit 1	Homo sapiens	63-67