PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3047000-7	1988	Turtle ANG I was generated by incubation at 0.5 ml plasma at pH 5.5 for 2 hr at 30 degrees with addition of dimercaprol and 8-hydroxyquinoline.	Oxyquinoline	124-142	angiotensinogen	Homo sapiens	7-12
2510550-3	1989	The reversible association of the Mg2+ ion with 8-hydroxyquinoline is a second-order process whose on and off rate constants are dependent on pH.	Oxyquinoline	48-66	mucin 7, secreted	Homo sapiens	34-37
2568020-1	1989	Both quinoline and 8-hydroxyquinoline (HOQ) were tested for their genotoxicity in CD1 male mice by using a bone marrow micronucleus assay.	Oxyquinoline	19-37	CD1 antigen complex	Mus musculus	82-85
2568020-1	1989	Both quinoline and 8-hydroxyquinoline (HOQ) were tested for their genotoxicity in CD1 male mice by using a bone marrow micronucleus assay.	Oxyquinoline	39-42	CD1 antigen complex	Mus musculus	82-85
12748703-0	1985	NTP Toxicology and Carcinogenesis Studies of 8-Hydroxyquinoline (CAS No.	Oxyquinoline	45-63	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	65-68
6090116-6	1984	ACE could be blocked by 8-hydroxyquinoline (100%) and phenanthroline (80%), but only slight inhibition was observed by teprotide (43%), EDTA (40%) and captopril (31%).	Oxyquinoline	24-42	angiotensin I converting enzyme	Homo sapiens	0-3
2983659-1	1985	Cyclic nucleotide phosphodiesterase activity in salt extracts of rat liver plasma membranes was progressively inactivated by treatment with the metal chelators 8-hydroxyquinoline and o-phenanthroline, but not the non-chelating m-phenanthroline isomer.	Oxyquinoline	160-178	phosphodiesterase 3A	Rattus norvegicus	0-35
6775860-7	1980	8-Hydroxyquinoline appears the preferable enzyme inhibitor for renin assay in rat plasma.	Oxyquinoline	0-18	renin	Rattus norvegicus	63-68
6300329-3	1983	Although EDTA and 8-hydroxyquinoline inhibit the 5"-nucleotidase from this source, it has not been possible to show the existence of metal ions in the enzyme molecule.	Oxyquinoline	18-36	5'-nucleotidase	Bos taurus	49-64
4206911-3	1974	The inhibition of diamine oxidase has been studied by using the following copper-chelating reagents: 1,10-phenanthroline; 2,2"-bipyridyl; 8-hydroxyquinoline (oxine); diethyldithiocarbamate and dithio-oxamide (rubeanic acid).	Oxyquinoline	138-156	amine oxidase copper containing 1	Homo sapiens	18-33
353531-4	1978	When present from T0 onward, 5 microgram/ml of 8-hydroxyquinoline severely inhibited premeiotic DNA replication and reduced the frequency of intragenic recombination at the ade 2  and leu 2 loci by 70 and 100%, respectively, relative to control cultures which did not have the inhibitor present.	Oxyquinoline	47-65	phosphoribosylaminoimidazole carboxylase ADE2	Saccharomyces cerevisiae S288C	173-178
353531-4	1978	When present from T0 onward, 5 microgram/ml of 8-hydroxyquinoline severely inhibited premeiotic DNA replication and reduced the frequency of intragenic recombination at the ade 2  and leu 2 loci by 70 and 100%, respectively, relative to control cultures which did not have the inhibitor present.	Oxyquinoline	47-65	3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae S288C	184-189
823752-2	1976	Inactivation of TRH immunoreactivity by serum is prevented by a mixture of 8-hydroxyquinoline sulphate and Tween 20.	Oxyquinoline	75-102	thyrotropin releasing hormone	Homo sapiens	16-19
404460-0	1977	[Suppression of pancreatic lipase activity by 8-oxyquinolin and tetracycline derivatives in acute pancreatitis].	Oxyquinoline	46-59	pancreatic lipase	Homo sapiens	16-33
1149258-14	1975	With a direct radioimmunoassay, angiotensin I was generated in plasma by 3 h incubation at 37 degrees C and pH 5.6 after addition of phenylmethanesulfonyl fluoride, 8-hydroxyquinoline and 2,3-dimercaptopropanol (dimercaprol).	Oxyquinoline	165-183	angiotensinogen	Homo sapiens	32-45
4206911-3	1974	The inhibition of diamine oxidase has been studied by using the following copper-chelating reagents: 1,10-phenanthroline; 2,2"-bipyridyl; 8-hydroxyquinoline (oxine); diethyldithiocarbamate and dithio-oxamide (rubeanic acid).	Oxyquinoline	158-163	amine oxidase copper containing 1	Homo sapiens	18-33
33909298-4	2021	Here, we endowed the helix dimer with 8-hydroxyquinoline (HQ) groups to achieve metal coordination and a shift to a beta-sheet structure.	Oxyquinoline	38-56	amyloid beta precursor protein	Homo sapiens	114-120
5583801-2	1967	Prevention of reoxidation of reduced cytochrome c by 8-hydroxyquinoline and m-phenylenediamine.	Oxyquinoline	53-71	cytochrome c, somatic	Homo sapiens	37-49
5583802-2	1967	Mechanism of 8-hydroxyquinoline in activating the aerobic reduction of cytochrome c.	Oxyquinoline	13-31	cytochrome c, somatic	Homo sapiens	71-83
33992968-0	2021	8-Hydroxyquinoline derived p-halo N4-phenyl substituted thiosemicarbazones: Crystal structures, spectral characterization and in vitro cytotoxic studies of their Co(III), Ni(II) and Cu(II) complexes.	Oxyquinoline	0-18	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	162-169
33992968-1	2021	The current paper deals with 8-hydroxyquinoline derived p-halo N4-phenyl substituted thiosemicarbazones, their crystal structures, spectral characterization and in vitro cytotoxic studies of Co(III), Ni(II) and Cu(II) complexes.	Oxyquinoline	29-47	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	191-198
31857834-1	2019	Here we first report the design of a series of bis-chelate Co(II) 5,7-dihalo-8-quinolinol-phenanthroline derivative complexes, [Co(py)(QL1)2] (Co1), [Co(py)(QL2)2] (Co2), [Co(Phen)(QL1)2] (Co3), [Co(Phen)(QL2)2] (Co4), [Co(DPQ)(QL1)2] (CH3OH)4 (Co5), [Co(DPQ)(QL2)2] (Co6), [Co(DPPZ)(QL1)2] CH3OH (Co7), [Co(MDP)(QL1)2] 3H2O (Co8), [Co(ODP)(QL1)2] CH3OH (Co9), [Co(PPT)(QL1)2] CH3OH (Co10), [Co(ClPT)(QL1)2] (Co11), [Co(dpy)(QL3)2] (Co12), [Co(mpy)(QL1)2] (Co13), [Co(Phen)(QL4)2] (Co14), [Co(ODP)(QL4)2] (Co15), [Co(mpy)(QL4)2]I (Co16), [Co(ClPT)(QL4)2] (Co17), and [Co(ClPT)(QL5)2] (Co18), with 5,7-dihalo-8-quinolinol and 2,2"-bipyridine mixed ligands.	Oxyquinoline	66-89	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-65
32155989-3	2020	In this study, we discovered a novel 1H-pyrrolo[2,3-b]pyridine derivative B10 as a GSK-3beta inhibitor that features with a quinolin-8-ol moiety to target the metal dyshomeostasis of AD.	Oxyquinoline	124-137	ectonucleotide pyrophosphatase/phosphodiesterase 3	Homo sapiens	74-77
32155989-3	2020	In this study, we discovered a novel 1H-pyrrolo[2,3-b]pyridine derivative B10 as a GSK-3beta inhibitor that features with a quinolin-8-ol moiety to target the metal dyshomeostasis of AD.	Oxyquinoline	124-137	glycogen synthase kinase 3 alpha	Homo sapiens	83-92
31839606-6	2020	Also, binding of Zn(II) and Cu(II) by GMP-1 is weaker than the 8-hydroxyquinoline scaffold compound clioquinol previously tested in AD clinical trials.	Oxyquinoline	63-81	small ubiquitin like modifier 1	Homo sapiens	38-43
33578252-0	2021	Electronic investigation of the effect of substituents on the SOD mimic activity of copper (II) complexes with 8-hydroxyquinoline-derived ligands.	Oxyquinoline	111-129	superoxide dismutase 1	Homo sapiens	62-65
33578252-1	2021	Density functional theory (DFT) calculations were used to study the superoxide dismutase (SOD) mimic activity of two Cu2+ complexes with ligands derived from 8-hydroxyquinoline (8-HQ).	Oxyquinoline	158-176	superoxide dismutase 1	Homo sapiens	68-88
33578252-1	2021	Density functional theory (DFT) calculations were used to study the superoxide dismutase (SOD) mimic activity of two Cu2+ complexes with ligands derived from 8-hydroxyquinoline (8-HQ).	Oxyquinoline	158-176	superoxide dismutase 1	Homo sapiens	90-93
32894466-4	2020	It was shown that oxyquinoline derivatives can mimic hypoxia by suppressing HIF-prolyl hydroxylases and the accumulation of HIF-1alpha.	Oxyquinoline	18-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-134
31378152-0	2020	Five novel palladium(II) complexes of 8-hydroxyquinoline and amino acids with hydrophobic side chains: synthesis, characterization, cytotoxicity, DNA- and BSA-interaction studies.	Oxyquinoline	38-56	albumin	Bos taurus	155-158
31888888-2	2020	We compiled a focused library consisting of >500 commercially available or newly synthetized 8-hydroxyquinoline (8OHQ) derivatives whose toxicity is paradoxically increased rather than decreased by the activity of P-glycoprotein (Pgp), a transporter conferring multidrug resistance (MDR).	Oxyquinoline	93-111	ATP binding cassette subfamily B member 1	Homo sapiens	214-228
31888888-2	2020	We compiled a focused library consisting of >500 commercially available or newly synthetized 8-hydroxyquinoline (8OHQ) derivatives whose toxicity is paradoxically increased rather than decreased by the activity of P-glycoprotein (Pgp), a transporter conferring multidrug resistance (MDR).	Oxyquinoline	93-111	ATP binding cassette subfamily B member 1	Homo sapiens	230-233
31415980-0	2019	Design, synthesis and preliminary bioactivity evaluations of 8-hydroxyquinoline derivatives as matrix metalloproteinase (MMP) inhibitors.	Oxyquinoline	61-79	matrix metallopeptidase 2	Homo sapiens	121-124
31415980-3	2019	Specially, it has been reported that 8-hydroxyquinoline derivatives serve as MMP-2 inhibitors with micromolar IC50 values.	Oxyquinoline	37-55	matrix metallopeptidase 2	Homo sapiens	77-82
31415980-4	2019	In the current study, a series of 8-hydroxyquinoline derivatives were designed and synthesized as new MMP-2 and MMP-9 inhibitors.	Oxyquinoline	34-52	matrix metallopeptidase 2	Homo sapiens	102-107
31415980-4	2019	In the current study, a series of 8-hydroxyquinoline derivatives were designed and synthesized as new MMP-2 and MMP-9 inhibitors.	Oxyquinoline	34-52	matrix metallopeptidase 9	Homo sapiens	112-117
30912784-1	2019	A tetradentate 8-hydroxyquinoline-based acyl hydrazone ligand (HL1 = 8-hydroxyquinoline-2-carboxaldehyde-(aminourea)hydrochloride) was elaborately used to construct a mononuclear dysprosium complex DyCl3HL1 CH3OH (1) with a nearly ideal pentagonal bipyramid coordination geometry (D5h) surrounding the Dy(iii) ion to achieve the significant performance of single-molecule magnets (SMMs).	Oxyquinoline	15-33	intelectin 1	Homo sapiens	63-66
31351379-1	2019	Searching for a more effective chemotherapy for the treatment of Human African trypanosomiasis, the disease caused by the parasite Trypanosoma brucei, and cancer, in the current work five new [PtII(L)(dppf)](PF6) compounds, with HL = 8-hydroxyquinoline derivatives and dppf = 1,1"-bis(diphenylphosphino)ferrocene, were synthesized and fully characterized.	Oxyquinoline	234-252	sperm associated antigen 17	Homo sapiens	208-211
29672046-2	2018	ortho-Phenylenediboronic acid mixed with 8-hydroxyquinoline in dioxane forms high-quality single crystals via slow solvent evaporation, which allows successful high resolution data collection (sin theta/lambda = 1.2 A-1) and charge density distribution modeling.	Oxyquinoline	41-59	embryonal Fyn-associated substrate	Homo sapiens	90-93
30530074-0	2019	Synthesis of 8-hydroxyquinoline glycoconjugates and preliminary assay of their beta1,4-GalT inhibitory and anti-cancer properties.	Oxyquinoline	13-31	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	79-91
30272964-0	2018	Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase.	Oxyquinoline	16-35	catechol-O-methyltransferase	Homo sapiens	53-81
30272964-1	2018	A series of 8-hydroxy quinolines were identified as potent inhibitors of catechol O-methyltransferase (COMT) with selectivity for the membrane-bound form of the enzyme.	Oxyquinoline	12-32	catechol-O-methyltransferase	Homo sapiens	73-101
30272964-1	2018	A series of 8-hydroxy quinolines were identified as potent inhibitors of catechol O-methyltransferase (COMT) with selectivity for the membrane-bound form of the enzyme.	Oxyquinoline	12-32	catechol-O-methyltransferase	Homo sapiens	103-107
31128475-11	2019	ADVANCES IN KNOWLEDGE AND IMPLICATIONS FOR PATIENT CARE: This novel approach for on-cartridge concentration and preparation of oxine and tropolone precursors with different positron emitters, in small volume and suitable pH, offers a versatile tool towards cell labelling for preclinical and clinical PET applications.	Oxyquinoline	127-132	thyroid stimulating hormone receptor	Mus musculus	301-304
30627900-6	2019	Using Affymetrix Human Transcriptome Array 2.0, we showed that the treatment with oxyquinoline derivative was followed by a decrease in the expression of claudins 6 and 7 (CLDN6, CLDN7), occludin (OCLN), contact adhesion molecule 3 (JAM3), and angiomotinlike protein 1 (AMOTL1).	Oxyquinoline	82-94	claudin 6	Homo sapiens	172-177
30627900-6	2019	Using Affymetrix Human Transcriptome Array 2.0, we showed that the treatment with oxyquinoline derivative was followed by a decrease in the expression of claudins 6 and 7 (CLDN6, CLDN7), occludin (OCLN), contact adhesion molecule 3 (JAM3), and angiomotinlike protein 1 (AMOTL1).	Oxyquinoline	82-94	claudin 7	Homo sapiens	179-184
30627900-6	2019	Using Affymetrix Human Transcriptome Array 2.0, we showed that the treatment with oxyquinoline derivative was followed by a decrease in the expression of claudins 6 and 7 (CLDN6, CLDN7), occludin (OCLN), contact adhesion molecule 3 (JAM3), and angiomotinlike protein 1 (AMOTL1).	Oxyquinoline	82-94	occludin	Homo sapiens	187-195
30627900-6	2019	Using Affymetrix Human Transcriptome Array 2.0, we showed that the treatment with oxyquinoline derivative was followed by a decrease in the expression of claudins 6 and 7 (CLDN6, CLDN7), occludin (OCLN), contact adhesion molecule 3 (JAM3), and angiomotinlike protein 1 (AMOTL1).	Oxyquinoline	82-94	occludin	Homo sapiens	197-201
30627900-6	2019	Using Affymetrix Human Transcriptome Array 2.0, we showed that the treatment with oxyquinoline derivative was followed by a decrease in the expression of claudins 6 and 7 (CLDN6, CLDN7), occludin (OCLN), contact adhesion molecule 3 (JAM3), and angiomotinlike protein 1 (AMOTL1).	Oxyquinoline	82-94	junctional adhesion molecule 3	Homo sapiens	233-237
30627900-6	2019	Using Affymetrix Human Transcriptome Array 2.0, we showed that the treatment with oxyquinoline derivative was followed by a decrease in the expression of claudins 6 and 7 (CLDN6, CLDN7), occludin (OCLN), contact adhesion molecule 3 (JAM3), and angiomotinlike protein 1 (AMOTL1).	Oxyquinoline	82-94	angiomotin like 1	Homo sapiens	270-276
30627907-4	2019	In human choriocarcinoma cells BeWo b30 (trophoblast model), oxyquinoline increased the expression of a core hypoxia response genes along with up-regulation of NOS3, PDK1, and BNIP3 genes and down-regulation of the PPARGC1B gene.	Oxyquinoline	61-73	nitric oxide synthase 3	Homo sapiens	160-164
30627907-4	2019	In human choriocarcinoma cells BeWo b30 (trophoblast model), oxyquinoline increased the expression of a core hypoxia response genes along with up-regulation of NOS3, PDK1, and BNIP3 genes and down-regulation of the PPARGC1B gene.	Oxyquinoline	61-73	pyruvate dehydrogenase kinase 1	Homo sapiens	166-170
30627907-4	2019	In human choriocarcinoma cells BeWo b30 (trophoblast model), oxyquinoline increased the expression of a core hypoxia response genes along with up-regulation of NOS3, PDK1, and BNIP3 genes and down-regulation of the PPARGC1B gene.	Oxyquinoline	61-73	BCL2 interacting protein 3	Homo sapiens	176-181
30627907-4	2019	In human choriocarcinoma cells BeWo b30 (trophoblast model), oxyquinoline increased the expression of a core hypoxia response genes along with up-regulation of NOS3, PDK1, and BNIP3 genes and down-regulation of the PPARGC1B gene.	Oxyquinoline	61-73	PPARG coactivator 1 beta	Homo sapiens	215-223
30076497-4	2018	When the C-5 of 8-hydroxyquinoline was replaced by halogen group, the fluorescence emission wavelengths had been red-shifted, at the same time, blue-shifted of fluorescence emission wavelength was observed when the C-5 position of 8-hydroxyquinoline was substituted by electron-withdrawing group.	Oxyquinoline	16-34	complement C5	Homo sapiens	9-12
30076497-4	2018	When the C-5 of 8-hydroxyquinoline was replaced by halogen group, the fluorescence emission wavelengths had been red-shifted, at the same time, blue-shifted of fluorescence emission wavelength was observed when the C-5 position of 8-hydroxyquinoline was substituted by electron-withdrawing group.	Oxyquinoline	16-34	complement C5	Homo sapiens	215-218
30076497-4	2018	When the C-5 of 8-hydroxyquinoline was replaced by halogen group, the fluorescence emission wavelengths had been red-shifted, at the same time, blue-shifted of fluorescence emission wavelength was observed when the C-5 position of 8-hydroxyquinoline was substituted by electron-withdrawing group.	Oxyquinoline	231-249	complement C5	Homo sapiens	9-12
30076497-4	2018	When the C-5 of 8-hydroxyquinoline was replaced by halogen group, the fluorescence emission wavelengths had been red-shifted, at the same time, blue-shifted of fluorescence emission wavelength was observed when the C-5 position of 8-hydroxyquinoline was substituted by electron-withdrawing group.	Oxyquinoline	231-249	complement C5	Homo sapiens	215-218
28939557-2	2018	We previously identified some zinc(II) chelators, including 8-quinolinol derivatives, that suppress apoptosis in attempts to discover compounds that target the zinc-binding site in p53.	Oxyquinoline	60-72	transformation related protein 53	Mus musculus	181-184
27862215-0	2016	Identification of 8-Hydroxyquinoline Derivatives Active Against Somatic V658F Mutant JAK1-Dependent Cells.	Oxyquinoline	18-36	Janus kinase 1	Rattus norvegicus	85-89
30109649-0	2018	Direct and Continuous Measurement of Phospholipase D Activities Using the Chelation-Enhanced Fluorescence Property of 8-Hydroxyquinoline.	Oxyquinoline	118-136	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	37-52
30109649-4	2018	Therefore, we designed a PLD assay that is based on the chelation-enhanced fluorescence property of 8-hydroxyquinoline.	Oxyquinoline	100-118	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	25-28
28007502-3	2017	The structural optimization for branched tail oxyquinolines containing an acetamide bond has been performed in the present study using HIF1 ODD-luc reporter assay.	Oxyquinoline	46-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	135-139
27760838-5	2017	In contrast, novel 8-hydroxyquinoline derivatives that we identify in the National Cancer Institute (NCI) drug repository possess a robust Pgp-dependent toxic activity across diverse cell lines.	Oxyquinoline	19-37	phosphoglycolate phosphatase	Mus musculus	139-142
27760838-7	2017	The discovery of new MDR-selective compounds shows the potential of this emerging technology and highlights the 8-hydroxyquinoline scaffold as a promising starting point for the development of compounds targeting the Achilles heel of drug-resistant cancer.	Oxyquinoline	112-130	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	21-24
28287667-0	2017	Comparative solution equilibrium studies of antitumor ruthenium(eta6-p-cymene) and rhodium(eta5-C5Me5) complexes of 8-hydroxyquinolines.	Oxyquinoline	116-135	endothelin receptor type A	Homo sapiens	64-67
27862215-4	2016	The screening yielded five new, experimentally validated inhibitors of JAK1 with 8-hydroxyquinoline as a novel hinge-binding scaffold.	Oxyquinoline	81-99	Janus kinase 1	Rattus norvegicus	71-75
26514291-15	2015	In conclusion, labelling of DTPA-DSPE LCL with (111)InCl3 represents a robust, easy and fast procedure which is preferred over the more laborious conventional labelling of DTPA-LCL with (111)In-oxine.	Oxyquinoline	194-199	lens cloudy	Mus musculus	38-41
26706114-0	2016	8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells.	Oxyquinoline	0-18	Ras converting CAAX endopeptidase 1	Homo sapiens	43-47
26944662-0	2016	Aqueous Co(II) adsorption using 8-hydroxyquinoline anchored gamma-Fe2O3@chitosan with Co(II) as imprinted ions.	Oxyquinoline	32-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-14
26944662-0	2016	Aqueous Co(II) adsorption using 8-hydroxyquinoline anchored gamma-Fe2O3@chitosan with Co(II) as imprinted ions.	Oxyquinoline	32-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	86-92
26944662-1	2016	A novel, bio-based 8-hydroxyquinoline (8-HQ) anchored magnetic chitosan using Co(II) as imprinted ions was prepared and applied for selective removal of Co(II) from aqueous solutions.	Oxyquinoline	19-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	78-84
26944662-1	2016	A novel, bio-based 8-hydroxyquinoline (8-HQ) anchored magnetic chitosan using Co(II) as imprinted ions was prepared and applied for selective removal of Co(II) from aqueous solutions.	Oxyquinoline	19-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	153-159
26150250-5	2015	One to two months later, pigs received 10 million indium-111 oxyquinoline (oxine)-labeled c-kit(pos) human cardiac stem cells (hCSCs) via intracoronary infusion with (n = 7) or without (n = 7) balloon inflation.	Oxyquinoline	75-80	KIT proto-oncogene, receptor tyrosine kinase	Sus scrofa	90-95
25076262-5	2014	8-Hydroxy quinoline and methylene blue are inhibitors of Cu and heme bound Abeta respectively, and are shown to efficiently reduce PROS formation in the oligomeric forms.	Oxyquinoline	0-19	amyloid beta precursor protein	Homo sapiens	75-80
25761396-2	2015	In this work, we investigate the interaction of amino derivative of 8-hydroxyquinoline, 2-amino-8-hydroxyquinoline (A8HQ), and the effects of its binding on the conformation of different isomers of human serum albumin (HSA) using multispectroscopic techniques and molecular modeling.	Oxyquinoline	68-86	albumin	Homo sapiens	204-217
25168232-0	2015	Investigations into the bovine serum albumin binding and fluorescence properties of Tb (III) complex of a novel 8-hydroxyquinoline ligand.	Oxyquinoline	112-130	albumin	Homo sapiens	31-44
25152615-7	2014	Cytotoxicity test against MRC-5 cells showed that Mn and Cu complexes (5 and 6), as well as free ligand 8HQ, exhibited activity with IC50 range 0.74-6.27 muM.	Oxyquinoline	104-107	latexin	Homo sapiens	154-157
25002230-4	2014	We report herein on the radioprotective activity of 8-hydroxyquinoline (8HQ) derivatives that were initially designed so as to interact with the Zn(2+) in p53.	Oxyquinoline	52-70	tumor protein p53	Homo sapiens	155-158
25026551-3	2014	Here, we show that an 8-hydroxyquinoline (8HQ) derivative, AS-2, suppresses p53-dependent apoptosis through a transcription-independent mechanism.	Oxyquinoline	22-40	arylsulfatase A	Mus musculus	59-63
25026551-3	2014	Here, we show that an 8-hydroxyquinoline (8HQ) derivative, AS-2, suppresses p53-dependent apoptosis through a transcription-independent mechanism.	Oxyquinoline	22-40	transformation related protein 53, pseudogene	Mus musculus	76-79
25026551-3	2014	Here, we show that an 8-hydroxyquinoline (8HQ) derivative, AS-2, suppresses p53-dependent apoptosis through a transcription-independent mechanism.	Oxyquinoline	42-45	arylsulfatase A	Mus musculus	59-63
25026551-3	2014	Here, we show that an 8-hydroxyquinoline (8HQ) derivative, AS-2, suppresses p53-dependent apoptosis through a transcription-independent mechanism.	Oxyquinoline	42-45	transformation related protein 53, pseudogene	Mus musculus	76-79
25002230-4	2014	We report herein on the radioprotective activity of 8-hydroxyquinoline (8HQ) derivatives that were initially designed so as to interact with the Zn(2+) in p53.	Oxyquinoline	72-75	tumor protein p53	Homo sapiens	155-158
23445471-0	2013	Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.	Oxyquinoline	28-46	PC4 and SFRS1 interacting protein 1	Homo sapiens	119-122
24627119-1	2014	Perylene diimide (PDI) 3 and 4 appended with 8-hydroxyquinoline derivatives have been synthesized and their photophysical and spectroscopic properties have been experimentally determined.	Oxyquinoline	45-63	peptidyl arginine deiminase 3	Homo sapiens	0-24
25335884-0	2014	8-Hydroxyquinoline and hydroxamic acid inhibitors of botulinum neurotoxin BoNT/A.	Oxyquinoline	0-18	neurotoxin	Clostridium botulinum	63-73
23445471-0	2013	Fragment-based discovery of 8-hydroxyquinoline inhibitors of the HIV-1 integrase-lens epithelium-derived growth factor/p75 (IN-LEDGF/p75) interaction.	Oxyquinoline	28-46	PC4 and SFRS1 interacting protein 1	Homo sapiens	133-136
23445471-1	2013	On the basis of an initial molecular modeling study suggesting the favorable binding of the "privileged" fragment 8-hydroxyquinoline with HIV-1 integrase (IN) at the IN-lens epithelium-derived growth factor/p75 (LEDGF/p75) interface , we developed a set of modified 8-hydroxyquinoline fragments demonstrating micromolar IC50 values for inhibition of the IN-LEDGF/p75 interaction, but significant cytotoxicity was associated with these initial compounds.	Oxyquinoline	114-132	PC4 and SFRS1 interacting protein 1	Homo sapiens	207-210
23445471-1	2013	On the basis of an initial molecular modeling study suggesting the favorable binding of the "privileged" fragment 8-hydroxyquinoline with HIV-1 integrase (IN) at the IN-lens epithelium-derived growth factor/p75 (LEDGF/p75) interface , we developed a set of modified 8-hydroxyquinoline fragments demonstrating micromolar IC50 values for inhibition of the IN-LEDGF/p75 interaction, but significant cytotoxicity was associated with these initial compounds.	Oxyquinoline	114-132	PC4 and SFRS1 interacting protein 1	Homo sapiens	218-221
23445471-1	2013	On the basis of an initial molecular modeling study suggesting the favorable binding of the "privileged" fragment 8-hydroxyquinoline with HIV-1 integrase (IN) at the IN-lens epithelium-derived growth factor/p75 (LEDGF/p75) interface , we developed a set of modified 8-hydroxyquinoline fragments demonstrating micromolar IC50 values for inhibition of the IN-LEDGF/p75 interaction, but significant cytotoxicity was associated with these initial compounds.	Oxyquinoline	114-132	PC4 and SFRS1 interacting protein 1	Homo sapiens	218-221
23445471-1	2013	On the basis of an initial molecular modeling study suggesting the favorable binding of the "privileged" fragment 8-hydroxyquinoline with HIV-1 integrase (IN) at the IN-lens epithelium-derived growth factor/p75 (LEDGF/p75) interface , we developed a set of modified 8-hydroxyquinoline fragments demonstrating micromolar IC50 values for inhibition of the IN-LEDGF/p75 interaction, but significant cytotoxicity was associated with these initial compounds.	Oxyquinoline	266-284	PC4 and SFRS1 interacting protein 1	Homo sapiens	207-210
23445471-4	2013	This is the first study providing evidence for 8-hydroxyquinolines as novel inhibitors of the IN-LEDGF/p75 interaction.	Oxyquinoline	47-66	PC4 and SFRS1 interacting protein 1	Homo sapiens	103-106
23330670-8	2013	We investigate the effect of azide and 8-hydroxyquinoline binding to Cu-Abeta and demonstrate the presence of a water-derived ligand and a second exchangeable ligand coordinated to copper at physiological pH, along the equatorial plane of a square-pyramidal active site.	Oxyquinoline	39-57	amyloid beta precursor protein	Homo sapiens	72-77
20545360-1	2010	Tacrine and PBT2 (an 8-hydroxyquinoline derivative) are well-known drugs that inhibit cholinesterases and decrease beta-amyloid (Abeta) levels by complexation of redox-active metals, respectively.	Oxyquinoline	21-39	amyloid beta precursor protein	Homo sapiens	129-134
23749135-5	2013	The metal ions were extracted through complexation with 8-hydroxyquinoline in the organic-rich phase with distribution constants and extraction percentage values, respectively, of 0.47 and 74 for Fe(III), 0.15 and 47 for Co(II), and 0.08 and 32 for Ni(II).	Oxyquinoline	56-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	221-226
22248233-6	2012	The effects on FOXO1a and gluconeogenic gene expression require the presence of Zn2+ ions, reminiscent of much earlier studies examining diabetogenic properties of 8-hydroxyquinolines.	Oxyquinoline	164-183	forkhead box O1	Homo sapiens	15-21
22685563-1	2012	Structural changes in human serum albumin (HSA) induced by the pollutants 1-naphthol, 2-naphthol and 8-quinolinol were analyzed by circular dichroism, fluorescence spectroscopy and dynamic light scattering.	Oxyquinoline	101-113	albumin	Homo sapiens	28-41
22073423-0	2004	(99m)Tc-Labeled murine IgM monoclonal antibody, fanolesomab, that targets the CD15 glycoprotein antigen Infection is one of the most common causes of morbidity in patients, especially for those who have undergone invasive surgery, and nuclear tracers such as (67)Ga-citrate and autologous leukocytes labeled with (111)In-oxine- or (99m)Tc-hexamethylpropyleneamine oxime ((111)In- or (99m)Tc-HMPAO) are often used to localize the infection to initiate treatment (1, 2).	Oxyquinoline	321-326	fucosyltransferase 4	Homo sapiens	78-82
21474822-2	2011	METHODS AND RESULTS: TNFalpha exposure of mouse lungs for 5 minutes produced a 3-fold increase in (125)I-anti-ICAM-1 monoclonal antibody (mAb) binding and (111)In oxine-labeled PMN sequestration, as well as Src activation, ICAM-1 Tyr518 phosphorylation, and phospho- Tyr518-ICAM-1 coimmunoprecipitation with actin.	Oxyquinoline	163-168	tumor necrosis factor	Mus musculus	21-29
21476586-3	2011	The two methyl substituents attached at C-1 and C-7 positions of boron-dipyrromethene (Bodipy) in compound 2 was revealed to prevent the free rotation of the 8-hydroxyquinoline (8-HQ) moiety, resulting in an almost vertical 8-HQ-Bodipy configuration of this compound.	Oxyquinoline	158-176	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	40-43
21476586-3	2011	The two methyl substituents attached at C-1 and C-7 positions of boron-dipyrromethene (Bodipy) in compound 2 was revealed to prevent the free rotation of the 8-hydroxyquinoline (8-HQ) moiety, resulting in an almost vertical 8-HQ-Bodipy configuration of this compound.	Oxyquinoline	158-176	complement C7	Homo sapiens	48-51
20512187-5	2010	In addition the complexes based upon L1-3 also possessed ligand-centred fluorescence, originating from either the quinoline or 8-hydroxyquinoline units of the axial ligands.	Oxyquinoline	127-145	immunoglobulin kappa variable 2-4 (pseudogene)	Homo sapiens	37-41
22426424-1	2012	Based on a multimodal drug design paradigm, we have synthesized a multifunctional non-toxic, brain permeable iron chelating compound, M30, possessing the neuroprotective N-propargyl moiety of the anti-Parkinsonian drug, monoamine oxidase (MAO)-B inhibitor, rasagiline and the antioxidant-iron chelator moiety of an 8-hydroxyquinoline derivative of the iron chelator, VK28.	Oxyquinoline	315-333	olfactory receptor family 10 subfamily N member 1	Mus musculus	134-137
19351130-0	2009	A density functional theory study of the topology of the charge density of complexes of 8-hydroxyquinoline with Mn(III), Fe(III), and Co(III).	Oxyquinoline	88-106	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	134-141
20396966-7	2010	Clioquinol and 8-Hydroxyquinoline bind to the active site of FIH-1 by coordinating the Fe(II) ion, thereby inhibiting the binding of a co-substrate, 2OG.	Oxyquinoline	15-33	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	61-66
20396966-8	2010	Contrary to other known FIH-1 inhibitors that have negative charges, Clioquinol and 8-hydroxyquinoline are neutral in charge and can provide a template for improved inhibitor design that can selectively inhibit FIH-1.	Oxyquinoline	84-102	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	211-216
19366358-4	2009	When isolated rat hepatocytes were preloaded with TAA-1, they were protected against iron-induced cell injury and oxidative stress elicited by exposure to the membrane-permeable iron complex Fe(III)/8-hydroxyquinoline.	Oxyquinoline	199-217	PVR cell adhesion molecule	Rattus norvegicus	50-55
19351130-0	2009	A density functional theory study of the topology of the charge density of complexes of 8-hydroxyquinoline with Mn(III), Fe(III), and Co(III).	Oxyquinoline	88-106	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	115-118
19351130-0	2009	A density functional theory study of the topology of the charge density of complexes of 8-hydroxyquinoline with Mn(III), Fe(III), and Co(III).	Oxyquinoline	88-106	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	124-127
21579023-1	2010	The Pb(II) atom in the title compound, [Pb(C(10)H(8)NO)(2)], is chelated by two oxine (2-methyl-quinolin-8-olate) anions in a Psi-trigonal-bipyramidal geometry; the N atoms occupy the axial sites.	Oxyquinoline	80-85	submaxillary gland androgen regulated protein 3B	Homo sapiens	4-10
20066682-2	2009	In dispersive liquid-liquid microextraction process, methanol and chloroform were used as disperser and extracting solvents, respectively, and the ligand 8-hydroxy quinoline was used as a chelating agent for the extraction of Co(II) and Fe(III).	Oxyquinoline	154-173	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	226-232
19351130-1	2009	By use of the quantum theory of atoms in molecules, it was found that the electronic charge distribution rho(r) of the metal atoms in Mn(III), Fe(III), and Co(III) complexes of 8-hydroxyquinoline (8HQ) showed eight nonbonded concentrations in their valence shell that were located at the corners of a cube and a depletion region was located in each of its six faces.	Oxyquinoline	177-195	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	137-140
19351130-1	2009	By use of the quantum theory of atoms in molecules, it was found that the electronic charge distribution rho(r) of the metal atoms in Mn(III), Fe(III), and Co(III) complexes of 8-hydroxyquinoline (8HQ) showed eight nonbonded concentrations in their valence shell that were located at the corners of a cube and a depletion region was located in each of its six faces.	Oxyquinoline	177-195	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	146-149
19351130-1	2009	By use of the quantum theory of atoms in molecules, it was found that the electronic charge distribution rho(r) of the metal atoms in Mn(III), Fe(III), and Co(III) complexes of 8-hydroxyquinoline (8HQ) showed eight nonbonded concentrations in their valence shell that were located at the corners of a cube and a depletion region was located in each of its six faces.	Oxyquinoline	177-195	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	156-163
19351130-1	2009	By use of the quantum theory of atoms in molecules, it was found that the electronic charge distribution rho(r) of the metal atoms in Mn(III), Fe(III), and Co(III) complexes of 8-hydroxyquinoline (8HQ) showed eight nonbonded concentrations in their valence shell that were located at the corners of a cube and a depletion region was located in each of its six faces.	Oxyquinoline	197-200	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	137-140
19351130-1	2009	By use of the quantum theory of atoms in molecules, it was found that the electronic charge distribution rho(r) of the metal atoms in Mn(III), Fe(III), and Co(III) complexes of 8-hydroxyquinoline (8HQ) showed eight nonbonded concentrations in their valence shell that were located at the corners of a cube and a depletion region was located in each of its six faces.	Oxyquinoline	197-200	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	146-149
19351130-1	2009	By use of the quantum theory of atoms in molecules, it was found that the electronic charge distribution rho(r) of the metal atoms in Mn(III), Fe(III), and Co(III) complexes of 8-hydroxyquinoline (8HQ) showed eight nonbonded concentrations in their valence shell that were located at the corners of a cube and a depletion region was located in each of its six faces.	Oxyquinoline	197-200	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	156-163
16239242-6	2005	We show here that exposure to moderate levels of ZnSO4, 8-hydroxyquinoline, ibuprofen and indomethacin produced a robust stress response resulting in the induction of HSP70 in HeLa cells expressing the mutant PABPN1 as a green fluorescent protein (GFP) fusion protein.	Oxyquinoline	56-74	heat shock protein family A (Hsp70) member 4	Homo sapiens	167-172
18041653-16	2007	In contrast, iron plus ionophore 8-hydroxyquinoline evoked GP IIb/IIIa activation.	Oxyquinoline	33-51	integrin subunit alpha 2b	Homo sapiens	59-65
17386559-2	2007	8-Hydroxyquinoline (8HQ) bonded covalently to a vinyl polymer resin, TSK-8HQ, was used in a chelating adsorbent column to concentrate the metals.	Oxyquinoline	0-18	tsukushi, small leucine rich proteoglycan	Homo sapiens	69-72
17386559-2	2007	8-Hydroxyquinoline (8HQ) bonded covalently to a vinyl polymer resin, TSK-8HQ, was used in a chelating adsorbent column to concentrate the metals.	Oxyquinoline	20-23	tsukushi, small leucine rich proteoglycan	Homo sapiens	69-72
17386559-2	2007	8-Hydroxyquinoline (8HQ) bonded covalently to a vinyl polymer resin, TSK-8HQ, was used in a chelating adsorbent column to concentrate the metals.	Oxyquinoline	73-76	tsukushi, small leucine rich proteoglycan	Homo sapiens	69-72
16643833-1	2006	We describe a simple, rapid, and sensitive fluorescence method for measurement of aluminum (Al) in human biological fluids, in dialysis solutions, and in tap water, which uses 8-hydroxyquinoline for ion chelation.	Oxyquinoline	176-194	nuclear RNA export factor 1	Homo sapiens	154-157
17278761-3	2006	On the basis of further studies, the masking agent of 8-hydroxyquinoline was used as an efficient agent to eliminate interference of As(V) emission and the heavy metal of Cu2+ and Pb2+ in the measurements of arsenic species.	Oxyquinoline	54-72	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	133-138
18614028-0	2008	Rapid restoration of cognition in Alzheimer"s transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.	Oxyquinoline	67-86	histocompatibility 2, class II antigen A, beta 1	Mus musculus	137-142
18343218-4	2008	Previously we have shown that treatment of cells expressing the mutant PABPN1 with a number of chemicals such as ibuprofen, indomethacin, ZnSO(4), and 8-hydroxy-quinoline induces HSP70 expression and reduces PABPN1 aggregation.	Oxyquinoline	151-170	poly(A) binding protein nuclear 1	Homo sapiens	71-77
18343218-4	2008	Previously we have shown that treatment of cells expressing the mutant PABPN1 with a number of chemicals such as ibuprofen, indomethacin, ZnSO(4), and 8-hydroxy-quinoline induces HSP70 expression and reduces PABPN1 aggregation.	Oxyquinoline	151-170	heat shock protein family A (Hsp70) member 4	Homo sapiens	179-184
18343218-4	2008	Previously we have shown that treatment of cells expressing the mutant PABPN1 with a number of chemicals such as ibuprofen, indomethacin, ZnSO(4), and 8-hydroxy-quinoline induces HSP70 expression and reduces PABPN1 aggregation.	Oxyquinoline	151-170	poly(A) binding protein nuclear 1	Homo sapiens	208-214
17680773-6	2007	We report that different classes of metal ligands including 8HQ and phenanthroline derivatives and the sulfur compound PDTC (pyrrolidine dithiocarbamate) elevated cellular metal levels (copper and zinc), and resulted in substantial loss of secreted Abeta.	Oxyquinoline	60-63	amyloid beta precursor protein	Homo sapiens	249-254
17680773-9	2007	Metal ligands that inhibited Abeta levels [e.g. CQ, 8HQ, NC (neocuproine), 1,10-phenanthroline and PDTC] induced metal-dependent activation of PI3K and JNK, resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta.	Oxyquinoline	52-55	amyloid beta precursor protein	Homo sapiens	29-34
17680773-9	2007	Metal ligands that inhibited Abeta levels [e.g. CQ, 8HQ, NC (neocuproine), 1,10-phenanthroline and PDTC] induced metal-dependent activation of PI3K and JNK, resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta.	Oxyquinoline	52-55	mitogen-activated protein kinase 8	Homo sapiens	152-155
17680773-9	2007	Metal ligands that inhibited Abeta levels [e.g. CQ, 8HQ, NC (neocuproine), 1,10-phenanthroline and PDTC] induced metal-dependent activation of PI3K and JNK, resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta.	Oxyquinoline	52-55	mitogen-activated protein kinase 8	Homo sapiens	170-173
17680773-9	2007	Metal ligands that inhibited Abeta levels [e.g. CQ, 8HQ, NC (neocuproine), 1,10-phenanthroline and PDTC] induced metal-dependent activation of PI3K and JNK, resulting in JNK-mediated up-regulation of metalloprotease activity and subsequent loss of secreted Abeta.	Oxyquinoline	52-55	amyloid beta precursor protein	Homo sapiens	257-262
16931007-0	2006	Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors.	Oxyquinoline	73-92	sarcosine dehydrogenase	Homo sapiens	39-42
16931007-0	2006	Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors.	Oxyquinoline	73-92	hypoxia inducible factor 1 subunit alpha	Homo sapiens	96-106
16931007-1	2006	A new series of potent 8-hydroxyquinolines was designed based on the newly resolved X-ray crystal structure of EGLN-1.	Oxyquinoline	23-42	egl-9 family hypoxia inducible factor 1	Homo sapiens	111-117
16239242-6	2005	We show here that exposure to moderate levels of ZnSO4, 8-hydroxyquinoline, ibuprofen and indomethacin produced a robust stress response resulting in the induction of HSP70 in HeLa cells expressing the mutant PABPN1 as a green fluorescent protein (GFP) fusion protein.	Oxyquinoline	56-74	poly(A) binding protein nuclear 1	Homo sapiens	209-215
16114243-0	2005	Affinity chromatography of porcine pepsin A using quinolin-8-ol as ligand.	Oxyquinoline	50-63	pepsinogen A5	Homo sapiens	35-43
16114243-1	2005	Stationary phase containing quinolin-8-ol immobilized on macroporous methacrylate support for the affinity chromatography of porcine pepsin A is described.	Oxyquinoline	28-41	pepsinogen A5	Homo sapiens	133-141
16114243-5	2005	The obtained findings confirm the applicability of affinity chromatography on the stationary phase with immobilized quinolin-8-ol to the isolation and determination of porcine pepsin A.	Oxyquinoline	116-129	pepsinogen A5	Homo sapiens	176-184
15737626-0	2005	8-Hydroxyquinoline inhibits iNOS expression and nitric oxide production by down-regulating LPS-induced activity of NF-kappaB and C/EBPbeta in Raw 264.7 cells.	Oxyquinoline	0-18	nitric oxide synthase 2, inducible	Mus musculus	28-32
15737626-0	2005	8-Hydroxyquinoline inhibits iNOS expression and nitric oxide production by down-regulating LPS-induced activity of NF-kappaB and C/EBPbeta in Raw 264.7 cells.	Oxyquinoline	0-18	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	129-138
15737626-2	2005	In Raw 264.7 cells stimulated with lipopolysaccharide (LPS) to mimic inflammation, 8-hydroxyquinoline (8HQ) inhibited the LPS-induced expression of both iNOS protein and mRNA in a parallel dose-dependent manner.	Oxyquinoline	83-101	nitric oxide synthase 2, inducible	Mus musculus	153-157
15737626-2	2005	In Raw 264.7 cells stimulated with lipopolysaccharide (LPS) to mimic inflammation, 8-hydroxyquinoline (8HQ) inhibited the LPS-induced expression of both iNOS protein and mRNA in a parallel dose-dependent manner.	Oxyquinoline	103-106	nitric oxide synthase 2, inducible	Mus musculus	153-157
15737626-4	2005	To investigate the mechanism by which 8HQ inhibits iNOS gene expression, we examined the activation of MAP kinases in Raw 264.7 cells.	Oxyquinoline	38-41	nitric oxide synthase 2, inducible	Mus musculus	51-55
15737626-6	2005	Moreover, 8HQ significantly inhibited the DNA-binding activity of nuclear factor-kappaB (NF-kappaB) and CCAAT/enhancer-binding protein beta (C/EBPbeta), but not activator protein-1 and cAMP response element-binding protein.	Oxyquinoline	10-13	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	104-139
15737626-6	2005	Moreover, 8HQ significantly inhibited the DNA-binding activity of nuclear factor-kappaB (NF-kappaB) and CCAAT/enhancer-binding protein beta (C/EBPbeta), but not activator protein-1 and cAMP response element-binding protein.	Oxyquinoline	10-13	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	141-150
15737626-7	2005	Taken together, these results suggest that 8HQ acts to inhibit inflammation through inhibition of NO production and iNOS expression through blockade of C/EBPbeta DNA-binding activity and NF-kappaB activation.	Oxyquinoline	43-46	nitric oxide synthase 2, inducible	Mus musculus	116-120
15737626-7	2005	Taken together, these results suggest that 8HQ acts to inhibit inflammation through inhibition of NO production and iNOS expression through blockade of C/EBPbeta DNA-binding activity and NF-kappaB activation.	Oxyquinoline	43-46	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	152-161
12848367-1	2003	Mixed ligand Co(II) and Ni(II) complexes have been synthesized by using 8-hydroxyquinoline as primary ligand and N- and/or O- donor ligands such as tartaric acid/phenylalanine as secondary ligands.	Oxyquinoline	72-90	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-30
15001696-4	2004	The aim of this study was to radiolabel CD34(+) hematopoietic PCs (HPCs) with (111)In-oxine and to evaluate the feasibility of this in vivo method for monitoring myocardial homing of transplanted cells in a rat myocardial infarction model.	Oxyquinoline	86-91	CD34 molecule	Rattus norvegicus	40-44
15333003-0	2004	Optimization of the auxiliary ligand shell of Cobalt(III)(8-hydroxyquinoline) complexes as model hypoxia-selective radiation-activated prodrugs.	Oxyquinoline	58-77	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	53-56
15333003-2	2004	This study investigates radiolytic release of 8-hydroxyquinoline (8-HQ), as a model for hydroxyaza-chloromethylbenzindoline DNA minor groove alkylators, from Co(III) complexes under hypoxia.	Oxyquinoline	46-64	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	158-165
14564438-2	2004	The oxine-bonded foam (Ox PUF) was characterized by use of different tools (UV-Vis spectra, IR spectra, density, and stability).	Oxyquinoline	4-9	NME/NM23 nucleoside diphosphate kinase 2	Homo sapiens	26-29
12434244-4	2002	The methods proposed in this paper are based on the transformation of all dissolved vanadium species in seawater into organic complexes by use of synthetic complexing agents such as dithizone, luminol, or 8-hydroxyquinoline; the resulting vanadium-organic complexes were sorbed on to a C(18) column at a flow rate of 5 mL min(-1).	Oxyquinoline	205-223	CD59 molecule (CD59 blood group)	Homo sapiens	322-328
15045339-2	1996	Co(II) is selectively recovered from an acidified sample with 8-quinolinol immobilized on silica gel.	Oxyquinoline	62-74	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
11289428-4	2001	The kinetics of three chemical systems are investigated, the binding of Mg2+ to 8-hydroxyquinoline as well as of Ca2+ and K+ to the cryptand [2.2.2], by carrying out standard stopped-flow binding as well as dissociation experiments employing various dilution factors.	Oxyquinoline	80-98	mucin 7, secreted	Homo sapiens	72-75
14963816-7	2002	Double mutant snm1-Delta cox11-Delta exhibited additivity of 8HQ and NDEA sensitivities of the single mutants, indicating that two different repair/recovery systems are involved in survival.	Oxyquinoline	61-64	Snm1p	Saccharomyces cerevisiae S288C	14-18
14963816-7	2002	Double mutant snm1-Delta cox11-Delta exhibited additivity of 8HQ and NDEA sensitivities of the single mutants, indicating that two different repair/recovery systems are involved in survival.	Oxyquinoline	61-64	Cox11p	Saccharomyces cerevisiae S288C	25-30
11770154-0	2001	The complexation of mercury (II) and organomercurial compounds by 8-hydroxyquinoline-bovine serum albumin conjugates.	Oxyquinoline	66-84	albumin	Homo sapiens	92-105
11770154-1	2001	The complexing properties of conjugates between 8-hydroxyquinoline and bovine serum albumin (Ox-BSA) towards inorganic and organic mercury were studied.	Oxyquinoline	48-66	albumin	Homo sapiens	78-91
7867719-6	1995	In the presence of 8-hydroxyquinoline, the wild-type strain underwent cell proliferation arrest and also exhibited metabolic uncoupling with bioenergetic and catabolic behavior similar to that of the cdc mutants at 37 degrees C. Experimental evidence obtained with cdc19, whose defective gene product is pyruvate kinase, suggests that the primary defect of cdc mutants correlates with a metabolically, highly uncoupled yeast cell.	Oxyquinoline	19-37	pyruvate kinase CDC19	Saccharomyces cerevisiae S288C	265-270
7945545-1	1994	Twenty-one derivatives of 8-hydroxyquinoline (oxine, 8H, CAS 148-24-3) were prepared and characterized by UV, IR, MS and NMR spectroscopy.	Oxyquinoline	26-44	BCAR1 scaffold protein, Cas family member	Homo sapiens	57-60
7937837-1	1994	A mutant of Escherichia coli, JTG10, deficient in gamma-glutamylcysteine synthetase (gamma-ECS; EC 6.3.2.2) is unable to synthesize glutathione (GSH) and is sensitive to 8-hydroxyquinoline.	Oxyquinoline	170-188	glutamate-cysteine ligase catalytic subunit	Homo sapiens	50-83
7937837-1	1994	A mutant of Escherichia coli, JTG10, deficient in gamma-glutamylcysteine synthetase (gamma-ECS; EC 6.3.2.2) is unable to synthesize glutathione (GSH) and is sensitive to 8-hydroxyquinoline.	Oxyquinoline	170-188	glutamate--cysteine ligase, chloroplastic	Nicotiana tabacum	85-94
34148302-3	2021	Fragment based screening of a non-specific metal chelator library demonstrates 8-hydroxyquinoline as a broad-spectrum nanomolar inhibitor against VIM-2 and NDM-1.	Oxyquinoline	79-97	vimentin 2, pseudogene	Homo sapiens	146-151
8501514-4	1993	Investigations into the mechanism of truncation revealed that metalloprotease inhibitors such as phenanthroline, bathophenanthroline, and 8-hydroxyquinoline (8-OHQ) blocked LNGFR truncation in a concentration-dependent fashion.	Oxyquinoline	138-156	nerve growth factor receptor	Rattus norvegicus	173-178
34148302-4	2021	A hit-based substructure search provided an early structure activity relationship of 8-hydroxyquinolines and identified 8-hydroxyquinoline-7-carboxylic acid as a low cytotoxic beta-lactamase inhibitor that can restore beta-lactam activity against VIM-2 expressing E. coli.	Oxyquinoline	85-104	vimentin 2, pseudogene	Homo sapiens	247-252
34994078-0	2022	Repurposing of 8-Hydroxyquinoline-based Butyrylcholinesterase and Cathepsin B Ligands as Potent Non-peptidic Deoxyribonuclease I Inhibitors.	Oxyquinoline	15-33	cathepsin B	Homo sapiens	66-77
34994078-3	2022	Three 8-hydroxyquinoline analogues inhibited both DNase I and BChE with IC50 values below 35 microM and 50 nM, respectively, while 2 nitroxoline derivatives inhibited DNase I and Cat B endopeptidase activity with IC50 values below 60 microM and 20 microM, respectively.	Oxyquinoline	6-24	butyrylcholinesterase	Homo sapiens	62-66
35204103-5	2022	The two oxyquinoline inhibitors exerted the same activation of HIF-triggered glycolytic pathways but opposite effects on signaling pathways linked to alternative substrates of HIF PHD 1 and 3, such as p53, NF-kappaB, and ATF4.	Oxyquinoline	8-20	tumor protein p53	Homo sapiens	201-204
35204103-5	2022	The two oxyquinoline inhibitors exerted the same activation of HIF-triggered glycolytic pathways but opposite effects on signaling pathways linked to alternative substrates of HIF PHD 1 and 3, such as p53, NF-kappaB, and ATF4.	Oxyquinoline	8-20	activating transcription factor 4	Homo sapiens	221-225
34093202-0	2021	An 8-Hydroxy-Quinoline Derivative Protects Against Lipopolysaccharide-Induced Lethality in Endotoxemia by Inhibiting HMGB1-Mediated Caspase-11 Signaling.	Oxyquinoline	3-22	high mobility group box 1	Mus musculus	117-122
34093202-5	2021	Here, we established a phenotypic screening system using recombinant HMGB1 plus LPS in mouse peritoneal macrophages, identifying a novel 8-hydroxyquinoline derivative named 7-(phenyl (pyridin-2-ylamino) methyl) quinolin-8-ol (8-ol, NSC84094) that can specifically inhibit HMGB1-mediated caspase-11 signaling.	Oxyquinoline	137-155	high mobility group box 1	Mus musculus	69-74
34093202-5	2021	Here, we established a phenotypic screening system using recombinant HMGB1 plus LPS in mouse peritoneal macrophages, identifying a novel 8-hydroxyquinoline derivative named 7-(phenyl (pyridin-2-ylamino) methyl) quinolin-8-ol (8-ol, NSC84094) that can specifically inhibit HMGB1-mediated caspase-11 signaling.	Oxyquinoline	137-155	high mobility group box 1	Mus musculus	272-277