PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
18420182-0	2008	Protein kinase C isozyme-specific potentiation of expressed Ca v 2.3 currents by acetyl-beta-methylcholine and phorbol-12-myristate, 13-acetate.	13-acetate	133-143	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	60-68
18248623-1	2008	We examined the mechanisms involved in protein kinase C (PKC)-dependent down-regulation of dopamine transporter (DAT) activity and cell surface expression by treating heterologously expressing cells with the clathrin-mediated endocytosis inhibitor concanavalin A (Con A) or the cholesterol depleter/membrane raft disrupter methyl-beta-cyclodextrin (MbetaC) prior to treatment with the PKC activator phorbol 12-myristate, 13-acetate (PMA).	13-acetate	421-431	solute carrier family 6 member 3	Homo sapiens	113-116
19167461-1	2009	Ca(v)2.2 high voltage-gated calcium channels are regulated by phorbol-12-myristae, 13-acetate (PMA) via Ser/Thr protein kinase C (PKC) phosphorylation sites in the I-II linker and C-terminus of the alpha(1) 2.2 subunit.	13-acetate	83-93	calcium channel, voltage-dependent, N type, alpha 1B subunit S homeolog	Xenopus laevis	0-8
18420182-1	2008	Protein kinase C (PKC) is implicated in the potentiation of Ca v 2.3 currents by acetyl-beta-methylcholine (MCh), a muscarinic M1 receptor agonist or phorbol-12-myristate, 13-acetate (PMA).	13-acetate	172-182	calcium channel, voltage-dependent, R type, alpha 1E subunit L homeolog	Xenopus laevis	60-68
17395152-5	2007	Short period activation of protein kinase C (PKC) by phorbol 12-myristate, 13-acetate (PMA) and alpha-adrenergic receptor agonist, phenylephrine (PE), downregulated sodium-dependent succinate transport presumably via hNaDC-3.	13-acetate	75-85	solute carrier family 13 member 3	Homo sapiens	217-224
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	13-acetate	85-95	granulin	Mus musculus	112-116
16873554-6	2006	Differentiation agents DMSO, and, in U-937 only, phorbol ester [phorbol 12-myristate,13-acetate (PMA)] elevated pgrn mRNA expression late in differentiation, suggestive of roles for pgrn in more mature terminally differentiated granulocyte/monocytes rather than during growth or differentiation.	13-acetate	85-95	granulin	Mus musculus	182-186
16704976-0	2006	Inhibitory role of Ser-425 of the alpha1 2.2 subunit in the enhancement of Cav 2.2 currents by phorbol-12-myristate, 13-acetate.	13-acetate	117-127	calcium channel, voltage-dependent, N type, alpha 1B subunit S homeolog	Xenopus laevis	75-82
16704976-1	2006	Voltage-gated calcium channels (Ca(v)) 2.2 currents are potentiated by phorbol-12-myristate, 13-acetate (PMA), whereas Ca(v) 2.3 currents are increased by both PMA and acetyl-beta-methylcholine (MCh).	13-acetate	93-103	calcium channel, voltage-dependent, N type, alpha 1B subunit S homeolog	Xenopus laevis	32-42
12388354-4	2002	Rat lymphocytes activated ex vivo with phorbol 12-myristate, 13-acetate increased K(f,c) in isolated lungs independently of I/R, and this increase was prevented by pretreating lungs with anti-CD40.	13-acetate	61-71	CD40 molecule	Rattus norvegicus	192-196
15741241-5	2005	The addition of phorbol 12-myristate,13-acetate (PMA) and forskolin to hepatocytes increased Hal mRNA concentration by 100 and 40%, respectively.	13-acetate	37-47	histidine ammonia lyase	Rattus norvegicus	93-96
15241487-3	2004	Another antiapoptotic family member, MCL1, exhibits a difference in electrophoretic mobility upon phosphorylation induced by an activator of PKC (12-O-tetradecanoylphorbol 13-acetate; TPA) versus agents that act on microtubules or protein phosphatases 1/2A.	13-acetate	172-182	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	37-41
14699138-5	2004	Next, we confirmed this interaction in vitro and in vivo, performed detailed mapping studies of the interaction sites of Ki-1/57 and RACK-1, and demonstrated that Ki-1/57 also co-precipitates with protein kinase C (PKC) when isolated from phorbol 12-myristate 13-acetate (PMA)-activated L540 tumor cells and is a substrate for PKC phosphorylation in vitro and in vivo.	13-acetate	260-270	hyaluronan binding protein 4	Homo sapiens	163-170
14978237-2	2004	The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2.	13-acetate	159-169	signal transducer and activator of transcription 1	Homo sapiens	30-80
14978237-2	2004	The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2.	13-acetate	159-169	signal transducer and activator of transcription 1	Homo sapiens	82-87
14978237-2	2004	The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2.	13-acetate	159-169	protein kinase C alpha	Homo sapiens	215-218
14978237-2	2004	The Tyr701 phosphorylation of signal transducer and activator of transcription 1 (STAT1) induced by interferon-gamma (IFN-gamma) and 12-O-tetradecanoylphorbol 13-acetate (TPA) was inhibited by the protein kinase C (PKC) inhibitor staurosporine, the tyrosine kinase inhibitor herbimycin, or the Src kinase inhibitor PP2.	13-acetate	159-169	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	315-318
11490365-10	2001	Both phorbol 12-myristate, 13-acetate and bryostatin-1, which selectively activate PKC epsilon in T84 cells, markedly attenuated the Isc response to ischemia.	13-acetate	27-37	protein kinase C epsilon	Homo sapiens	83-94
11553507-5	2001	However, phorbol 12-myristate 13-acetate (PMA) stimulation of cells grown in the presence of high glucose resulted in membrane translocation of PKC-beta(I) that was associated with nuclear translocation of NF-kappaB p65, but not NF-kappaB p50.	13-acetate	30-40	protein kinase C, beta	Rattus norvegicus	144-152
11553507-5	2001	However, phorbol 12-myristate 13-acetate (PMA) stimulation of cells grown in the presence of high glucose resulted in membrane translocation of PKC-beta(I) that was associated with nuclear translocation of NF-kappaB p65, but not NF-kappaB p50.	13-acetate	30-40	synaptotagmin 1	Rattus norvegicus	216-219
11543740-4	2001	RESULTS: Receptor for activated C kinase-1 was located exclusively in membranes and, in control brains, the levels of RACK1 that coimmunoprecipitated with most PKC isozymes were increased by stimulation with the PKC activator, phorbol 12-myristate, 13-acetate (PMA).	13-acetate	249-259	receptor for activated C kinase 1	Homo sapiens	9-42
11543740-4	2001	RESULTS: Receptor for activated C kinase-1 was located exclusively in membranes and, in control brains, the levels of RACK1 that coimmunoprecipitated with most PKC isozymes were increased by stimulation with the PKC activator, phorbol 12-myristate, 13-acetate (PMA).	13-acetate	249-259	receptor for activated C kinase 1	Homo sapiens	118-123
11467851-4	2001	Phorbol 12-myristate, 13-acetate (PMA)-stimulated APP secretion, which was reduced by a general PKC inhibitor bisindoylmaleimide I, but not by Go 6976, which inhibits PKCalpha, beta, gamma, and mu.	13-acetate	22-32	protein kinase C alpha	Homo sapiens	96-99
11467851-4	2001	Phorbol 12-myristate, 13-acetate (PMA)-stimulated APP secretion, which was reduced by a general PKC inhibitor bisindoylmaleimide I, but not by Go 6976, which inhibits PKCalpha, beta, gamma, and mu.	13-acetate	22-32	protein kinase C alpha	Homo sapiens	167-175
10888256-7	2000	The levels of VEGF mRNA in CEVM were significantly augmented by forskolin (100 microM), or phorbol 12-myristate, 13-acetate (200 nM) in a time-dependent manner in CEVM.	13-acetate	113-123	vascular endothelial growth factor A	Gallus gallus	14-18
10200423-4	1999	Maximal activation of PKC using the phorbol esters, 4beta-phorbol 12-myristate, 13-acetate (PMA), phorbol 12, 13 dibutyrate (PDBu) and 12-deoxyphorbol 13-phenylacetate (dPPA) elicited a rapid, and sustained, inhibition of the outward steady-state voltage- and calcium- dependent potassium current predominantly carried through BK channels.	13-acetate	80-90	protein kinase C, alpha	Mus musculus	22-25
10446305-3	1999	In the present study, the transport of succinate in Xenopus oocytes expressing NaDC-1 was inhibited up to 95% by two activators of protein kinase C, phorbol 12-myristate, 13-acetate (PMA) and sn-1, 2-dioctanoylglycerol (DOG).	13-acetate	171-181	solute carrier family 13 member 2L homeolog	Xenopus laevis	79-85
9927206-3	1999	Pretreatment of murine NIH3T3 and human 293 cells with 5 microM taxol resulted in complete inhibition of phorbol, 12-myristate, 13-acetate (PMA) mediated NF-kappaB activation, detected as the loss of DNA binding and reduced NF-kappaB dependent reporter gene activity.	13-acetate	128-138	nuclear factor kappa B subunit 1	Homo sapiens	154-163
9844106-4	1998	During a 3-day treatment with phorbol 12-myristate, 13-acetate (PMA), which induces differentiation of FLG 29.1 cells toward an osteoclast-like phenotype, the levels of Src and Fyn increased and the levels of Lyn decreased.	13-acetate	52-62	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	169-172
9844106-4	1998	During a 3-day treatment with phorbol 12-myristate, 13-acetate (PMA), which induces differentiation of FLG 29.1 cells toward an osteoclast-like phenotype, the levels of Src and Fyn increased and the levels of Lyn decreased.	13-acetate	52-62	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	177-180
9844106-4	1998	During a 3-day treatment with phorbol 12-myristate, 13-acetate (PMA), which induces differentiation of FLG 29.1 cells toward an osteoclast-like phenotype, the levels of Src and Fyn increased and the levels of Lyn decreased.	13-acetate	52-62	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	209-212
9706014-10	1998	The effects of TRH were mimicked by direct pharmacological activation of protein kinase C (PKC) with beta-phorbol 12-myristate, 13-acetate (PMA).	13-acetate	128-138	thyrotropin releasing hormone	Homo sapiens	15-18
9574865-5	1998	We depleted PKC from PC12 cells by prolonged (48 h) exposure to high concentration of phorbol 12-myristate, 13-acetate (PMA, 100 nM), and then determined the expression of: (1) c-fos mRNA by Northern blot (2) PKC isoforms, tyrosine phosphorylated and unphosphorylated MAP (mitogen activated protein) kinases by Western blot.	13-acetate	108-118	protein kinase C, alpha	Rattus norvegicus	12-15
11324578-2	1998	The results were as follows: (1) PKC agonist phorbol-12-myristate, 13-acetate (PMA) stimulated the glutamate uptake in the rat cerebral cortex synaptosomes and cell line of BT-325, but not in the cell line of SK-N-SH.	13-acetate	67-77	protein kinase C, gamma	Rattus norvegicus	33-36
11324523-4	1998	All of these ET-1-induced cardiomyocyte hypertrophic responses were completely blocked by pretreatment with staurosporine (2 nmol/L), a protein kinase C inhibitor, and stimulated by 4-phorbol, 12-myristate, 13-acetate (PMA) (10(-8)-10(-6) mol/L), a protein kinase C activator, in a dose-dependent manner.	13-acetate	207-217	endothelin 1	Rattus norvegicus	13-17
9515165-5	1998	Moreover, the PKC-activating phorbol ester, phorbol-12-myristate, 13-acetate (PMA) caused an increase in PDE-4 activity, similar to that observed in cells challenged with anti-CD3 monoclonal antibodies and which was not additive with cochallenge using anti-CD3 antibodies.	13-acetate	66-76	CD3 antigen, epsilon polypeptide	Mus musculus	176-179
9515165-5	1998	Moreover, the PKC-activating phorbol ester, phorbol-12-myristate, 13-acetate (PMA) caused an increase in PDE-4 activity, similar to that observed in cells challenged with anti-CD3 monoclonal antibodies and which was not additive with cochallenge using anti-CD3 antibodies.	13-acetate	66-76	CD3 antigen, epsilon polypeptide	Mus musculus	257-260
9144337-5	1997	Brief treatment of parathyroid and HEK-CaR cells with an activator of protein kinase C (PKC), phorbol 12-myristate,13-acetate (PMA), stimulated PLD activity at both low and high Ca2+(o).	13-acetate	115-125	calcium sensing receptor	Homo sapiens	39-42
9359473-7	1997	On the phorbol 12-myristate, 13-acetate (PMA)-stimulated 3 beta-HSD-1, 17beta-HSD-1 and P450scc mRNA levels only the lowest concentration of A23187 potentialized the PMA effect on the 17 beta-HSD-1 mRNA levels.	13-acetate	29-39	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	88-95
9359473-7	1997	On the phorbol 12-myristate, 13-acetate (PMA)-stimulated 3 beta-HSD-1, 17beta-HSD-1 and P450scc mRNA levels only the lowest concentration of A23187 potentialized the PMA effect on the 17 beta-HSD-1 mRNA levels.	13-acetate	29-39	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	184-197
9144337-5	1997	Brief treatment of parathyroid and HEK-CaR cells with an activator of protein kinase C (PKC), phorbol 12-myristate,13-acetate (PMA), stimulated PLD activity at both low and high Ca2+(o).	13-acetate	115-125	proline rich transmembrane protein 2	Homo sapiens	70-86
9144337-5	1997	Brief treatment of parathyroid and HEK-CaR cells with an activator of protein kinase C (PKC), phorbol 12-myristate,13-acetate (PMA), stimulated PLD activity at both low and high Ca2+(o).	13-acetate	115-125	proline rich transmembrane protein 2	Homo sapiens	88-91
9144337-5	1997	Brief treatment of parathyroid and HEK-CaR cells with an activator of protein kinase C (PKC), phorbol 12-myristate,13-acetate (PMA), stimulated PLD activity at both low and high Ca2+(o).	13-acetate	115-125	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	144-147
9047000-4	1997	In vitro treatment with a phorbol ester (phorbol 12-myristate, 13-acetate), but not a cAMP analogue (8-bromo-cAMP), significantly increased uPA mRNA levels in both granulosa and theca tissue from the largest and second-largest preovulatory follicles.	13-acetate	63-73	plasminogen activator, urokinase	Gallus gallus	140-143
8648910-6	1996	Short term incubation (5 min) with the active phorbol ester, phorbol 12-myristate, 13-acetate (PMA), 10(-7) M, caused a significant stimulation of the Na-HCO3 cotransporter activity as compared to controls.	13-acetate	83-93	electrogenic sodium bicarbonate cotransporter 1	Oryctolagus cuniculus	151-172
9013781-10	1996	When GT1-7 cells are treated with the phorbol ester PMA (phorbol, 12-myristate, 13-acetate) for 1 h, GnRH primary transcript levels decrease by approximately 70%.	13-acetate	80-90	gonadotropin releasing hormone 1	Mus musculus	101-105
8977326-4	1996	Here we demonstrate that phorbol ester phorbol 12-myrislate 13-acetate (PMA), which increases tyrosine phosphorylation by stimulating protein kinase C and p21ras, can overcome the CTLA-4-mediated inhibition of T cell proliferation.	13-acetate	60-70	Harvey rat sarcoma virus oncogene	Mus musculus	155-161
8977326-4	1996	Here we demonstrate that phorbol ester phorbol 12-myrislate 13-acetate (PMA), which increases tyrosine phosphorylation by stimulating protein kinase C and p21ras, can overcome the CTLA-4-mediated inhibition of T cell proliferation.	13-acetate	60-70	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	180-186
1332716-10	1992	Additionally, as found for Ang II, preincubation of VSMC with either phorbol 12-myristate, 13-acetate, forskolin or 8-bromo-cyclic GMP inhibited LDL- and HDL-induced accumulation of [3H]-inositol monophosphate.	13-acetate	91-101	angiotensinogen	Homo sapiens	27-33
7666012-4	1995	Protein kinase C activation with phorbol 12-myristate, 13-acetate (100 nM) decreased cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by 71 +/- 5% and 60 +/- 16%, respectively, within 3 h. mRNA levels recovered to control levels by 18-24 h, however, consistent with downregulation of protein kinase C. Furthermore, after depletion of protein kinase C with a 24-h preincubation with phorbol diesters, taurocholate (25 microM) repressed cholesterol 7 alpha-hydroxylase mRNA by only 14 +/- 17%.	13-acetate	55-65	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	85-116
7666012-4	1995	Protein kinase C activation with phorbol 12-myristate, 13-acetate (100 nM) decreased cholesterol 7 alpha-hydroxylase mRNA and transcriptional activity by 71 +/- 5% and 60 +/- 16%, respectively, within 3 h. mRNA levels recovered to control levels by 18-24 h, however, consistent with downregulation of protein kinase C. Furthermore, after depletion of protein kinase C with a 24-h preincubation with phorbol diesters, taurocholate (25 microM) repressed cholesterol 7 alpha-hydroxylase mRNA by only 14 +/- 17%.	13-acetate	55-65	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	452-483
8504157-3	1993	The PLD was shown to be activated by phorbol, 12-myristate, 13-acetate (PMA), calcium ionophore A23187, oxytocin, bombesin and bradykinin, but not by platelet-activating factor (PAF) and epidermal growth factor (EGF).	13-acetate	60-70	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	4-7
8454058-1	1993	Phorbol esters such as phorbol 12-myristate,13-acetate (PMA) are potent activators of protein kinase C (PKC), and activate all PKC isozymes except zeta and lambda.	13-acetate	44-54	protein kinase C alpha	Homo sapiens	104-107
8454058-1	1993	Phorbol esters such as phorbol 12-myristate,13-acetate (PMA) are potent activators of protein kinase C (PKC), and activate all PKC isozymes except zeta and lambda.	13-acetate	44-54	protein kinase C alpha	Homo sapiens	127-130
2162944-7	1990	Incubation with carbachol, ATP or phorbol 12-myristate, 13-acetate desensitized the subsequent [Ca2+]i response to neurotensin.	13-acetate	56-66	neurotensin	Homo sapiens	115-126
1280118-2	1992	Prior exposure of cells to 6 x 10(-7) M phorbol 12-myristate, 13-acetate for 15 min resulted in a 40-50% inhibition of CGRP II-dependent cAMP stimulation.	13-acetate	62-72	calcitonin related polypeptide beta	Homo sapiens	119-126
1800956-4	1991	The effect of gastrin was comparable to the stimulation induced by phorbol 12-myristate, 13-acetate (PMA), a strong activator of protein kinase C. The increase in protein synthesis induced by gastrin was totally abolished by 1-(5-isoquinolinyl)-2-methylpiperazine, an inhibitor of protein kinase C activity.	13-acetate	89-99	gastrin	Rattus norvegicus	192-199
1953275-6	1991	The influence of protein kinase C and that of G proteins on the mitogenesis in cells stimulated by thrombin or AVP was determined by pretreating cells with phorbol 12-myristate, 13-acetate (TPA) and pertussis toxin, respectively.	13-acetate	178-188	coagulation factor II	Rattus norvegicus	99-107
1953275-6	1991	The influence of protein kinase C and that of G proteins on the mitogenesis in cells stimulated by thrombin or AVP was determined by pretreating cells with phorbol 12-myristate, 13-acetate (TPA) and pertussis toxin, respectively.	13-acetate	178-188	arginine vasopressin	Rattus norvegicus	111-114
1711295-4	1991	Attachment of phorbol 12-myristate, 13-acetate (PMA)-stimulated W256 cells to endothelial monolayers was increased 1.8 +/- 0.1-fold and damage (3H-2-deoxyglucose release from labeled endothelium) 1.4 +/- 0.1-fold after 4-hour pretreatment of the endothelium with 10 ng/ml recombinant human interleukin-1 alpha (rIL-1 alpha).	13-acetate	36-46	interleukin 1 alpha	Homo sapiens	290-309
1711295-4	1991	Attachment of phorbol 12-myristate, 13-acetate (PMA)-stimulated W256 cells to endothelial monolayers was increased 1.8 +/- 0.1-fold and damage (3H-2-deoxyglucose release from labeled endothelium) 1.4 +/- 0.1-fold after 4-hour pretreatment of the endothelium with 10 ng/ml recombinant human interleukin-1 alpha (rIL-1 alpha).	13-acetate	36-46	interleukin 1 alpha	Rattus norvegicus	311-322
1676985-7	1991	The addition of small amounts of phorbol 12-myristate, 13-acetate, but not Ca2+ ionophore A23187, is able to overcome the defect, thereby suggesting a direct PKC involvement.	13-acetate	55-65	proline rich transmembrane protein 2	Homo sapiens	158-161
2162944-2	1990	Preincubation with neurotensin or phorbol 12-myristate, 13-acetate decreased the number of cell surface neurotensin receptors and neurotensin-induced increases of inositol trisphosphates and [Ca2+]i.	13-acetate	56-66	neurotensin	Homo sapiens	19-30
2162944-2	1990	Preincubation with neurotensin or phorbol 12-myristate, 13-acetate decreased the number of cell surface neurotensin receptors and neurotensin-induced increases of inositol trisphosphates and [Ca2+]i.	13-acetate	56-66	neurotensin	Homo sapiens	104-115
2162944-2	1990	Preincubation with neurotensin or phorbol 12-myristate, 13-acetate decreased the number of cell surface neurotensin receptors and neurotensin-induced increases of inositol trisphosphates and [Ca2+]i.	13-acetate	56-66	neurotensin	Homo sapiens	104-115
2159182-4	1990	The protein kinase C activator, phorbol 12-myristate, 13-acetate, mimicked PAF in the binding assay.	13-acetate	54-64	PCNA clamp associated factor	Homo sapiens	75-78
34837563-0	2022	Correction to: Proteasome-dependent inactivation of Akt is essential for 12-O-tetradecanoylphorbol 13-acetate-induced apoptosis in vascular smooth muscle cells.	13-acetate	99-109	AKT serine/threonine kinase 1	Homo sapiens	52-55
2250559-1	1990	Protein kinase C (PKC) activity and translocation in response to the phorbol ester, phorbol 12-myristate, 13-acetate (PMA), serotonin (5-HT) and thrombin was assessed in human platelets.	13-acetate	106-116	coagulation factor II, thrombin	Homo sapiens	145-153
1688390-1	1990	Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion.	13-acetate	64-74	protein kinase C, gamma	Rattus norvegicus	84-100
1688390-1	1990	Pretreatment of rat pancreatic acini with phorbol 12-myristate, 13-acetate (PMA), a protein kinase C (PK-C) activator, caused the desensitization of carbamylcholine (CBC)-induced amylase release in a concentration- and time-dependent fashion.	13-acetate	64-74	protein kinase C, gamma	Rattus norvegicus	102-106
2540997-1	1989	We have examined the effects of a biologically active tumor promoting phorbol ester (phorbol 12-myristate, 13-acetate (PMA] which activates protein kinase C (PKC) on melanotropin receptor function and cell growth in the M2R mouse melanoma cell clone.	13-acetate	107-117	melanocortin 1 receptor	Homo sapiens	166-187
2570066-2	1989	Previous studies have shown that palytoxin, a non-(12-O-tetradecanoylphorbol-13-acetate)-type tumor promoter, is able to down-modulate the epidermal growth factor (EGF) receptor through a sodium-dependent pathway in Swiss 3T3 cells.	13-acetate	77-87	epidermal growth factor receptor	Mus musculus	139-177
2475257-0	1989	Anti-CD4 monoclonal antibodies enhance phorbol 12-myristate, 13-acetate-induced activation of human T cells.	13-acetate	61-71	CD4 molecule	Homo sapiens	5-8
2475257-3	1989	In the present study, we examined different anti-CD4 monoclonal antibodies (mAbs) for their ability to influence lymphocyte proliferation induced by phorbol 12-myristate, 13-acetate (PMA).	13-acetate	171-181	CD4 molecule	Homo sapiens	49-52
2846820-1	1988	In this study we have characterized and compared the regulation of the HT29 cell vasoactive intestinal peptide receptor/adenylate cyclase system (VIP-R/AC) by the VIP-R agonist peptide histidineisoleucineamide (PHI) and by activators of protein kinase C (PKC) including phorbol 12-myristate, 13-acetate (PMA) and mezerein.	13-acetate	292-302	vasoactive intestinal peptide receptor 1	Homo sapiens	146-154
2846820-1	1988	In this study we have characterized and compared the regulation of the HT29 cell vasoactive intestinal peptide receptor/adenylate cyclase system (VIP-R/AC) by the VIP-R agonist peptide histidineisoleucineamide (PHI) and by activators of protein kinase C (PKC) including phorbol 12-myristate, 13-acetate (PMA) and mezerein.	13-acetate	292-302	vasoactive intestinal peptide receptor 1	Homo sapiens	146-151
2989297-2	1985	Phorbol 12-myristate, 13-acetate, the calcium ionophore A23187 in the presence or absence of EGTA, and the fluorescent calcium chelator quin-2 also cause an increase in cytoskeletal actin.	13-acetate	22-32	actin	Oryctolagus cuniculus	182-187
2989297-3	1985	The stimulated increases in the cytoskeletal actin are not dependent on a rise in the intracellular concentration of free calcium and are not mediated by an increase in the intracellular pH or activation of protein kinase C. The increases in the cytoskeletal actin produced by fMet-Leu-Phe and leukotriene B4, but not by phorbol 12-myristate, 13-acetate, are inhibited by high osmolarity.	13-acetate	343-353	actin	Oryctolagus cuniculus	45-50
2989297-3	1985	The stimulated increases in the cytoskeletal actin are not dependent on a rise in the intracellular concentration of free calcium and are not mediated by an increase in the intracellular pH or activation of protein kinase C. The increases in the cytoskeletal actin produced by fMet-Leu-Phe and leukotriene B4, but not by phorbol 12-myristate, 13-acetate, are inhibited by high osmolarity.	13-acetate	343-353	actin	Oryctolagus cuniculus	259-264
2838621-4	1988	Endogenous phosphorylation of B-50 in SPM is enhanced in a concentration-dependent manner by the tumor-promoting phorbol diesters 4 beta-phorbol 12-myristate, 13-acetate, 4 beta-phorbol 12,13-dibutyrate (PDB) and 4 beta-phorbol 12,13-diacetate, with an EC50 of 7 x 10(-8) M, 3 x 10(-7) M and 10(-6) M, respectively.	13-acetate	159-169	growth associated protein 43	Homo sapiens	30-34
31086026-5	2019	Additionally, we found that flaccidoxide-13-acetate treatment upregulated the expressions of cleaved caspase 3, cleaved caspase 9, Bax, and Bad, and down-regulated the expressions of Bcl-2, p-Bad, Bcl-x1, and Mcl-1.	13-acetate	41-51	caspase 3	Homo sapiens	101-110
31086026-5	2019	Additionally, we found that flaccidoxide-13-acetate treatment upregulated the expressions of cleaved caspase 3, cleaved caspase 9, Bax, and Bad, and down-regulated the expressions of Bcl-2, p-Bad, Bcl-x1, and Mcl-1.	13-acetate	41-51	caspase 9	Homo sapiens	120-129
31086026-5	2019	Additionally, we found that flaccidoxide-13-acetate treatment upregulated the expressions of cleaved caspase 3, cleaved caspase 9, Bax, and Bad, and down-regulated the expressions of Bcl-2, p-Bad, Bcl-x1, and Mcl-1.	13-acetate	41-51	BCL2 associated X, apoptosis regulator	Homo sapiens	131-134
31086026-5	2019	Additionally, we found that flaccidoxide-13-acetate treatment upregulated the expressions of cleaved caspase 3, cleaved caspase 9, Bax, and Bad, and down-regulated the expressions of Bcl-2, p-Bad, Bcl-x1, and Mcl-1.	13-acetate	41-51	BCL2 apoptosis regulator	Homo sapiens	183-188
31086026-5	2019	Additionally, we found that flaccidoxide-13-acetate treatment upregulated the expressions of cleaved caspase 3, cleaved caspase 9, Bax, and Bad, and down-regulated the expressions of Bcl-2, p-Bad, Bcl-x1, and Mcl-1.	13-acetate	41-51	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	209-214
31086026-8	2019	Moreover, we examined the PI3K/AKT signal pathway, and found that the expressions of phosphorylated PI3K (p-PI3K) and AKT (p-AKT) were decreased with flaccidoxide-13-acetate concentrations.	13-acetate	163-173	AKT serine/threonine kinase 1	Homo sapiens	31-34
31086026-8	2019	Moreover, we examined the PI3K/AKT signal pathway, and found that the expressions of phosphorylated PI3K (p-PI3K) and AKT (p-AKT) were decreased with flaccidoxide-13-acetate concentrations.	13-acetate	163-173	AKT serine/threonine kinase 1	Homo sapiens	118-121
31086026-8	2019	Moreover, we examined the PI3K/AKT signal pathway, and found that the expressions of phosphorylated PI3K (p-PI3K) and AKT (p-AKT) were decreased with flaccidoxide-13-acetate concentrations.	13-acetate	163-173	AKT serine/threonine kinase 1	Homo sapiens	118-121
31086026-10	2019	The results support the idea that flaccidoxide-13-acetate-induced apoptosis is mediated by mitochondrial dysfunction, ER stress, and activation of both the p38 and JNK pathways, and also relies on inhibition of PI3K/AKT signaling.	13-acetate	47-57	mitogen-activated protein kinase 14	Homo sapiens	156-159
31086026-10	2019	The results support the idea that flaccidoxide-13-acetate-induced apoptosis is mediated by mitochondrial dysfunction, ER stress, and activation of both the p38 and JNK pathways, and also relies on inhibition of PI3K/AKT signaling.	13-acetate	47-57	mitogen-activated protein kinase 8	Homo sapiens	164-167
31086026-10	2019	The results support the idea that flaccidoxide-13-acetate-induced apoptosis is mediated by mitochondrial dysfunction, ER stress, and activation of both the p38 and JNK pathways, and also relies on inhibition of PI3K/AKT signaling.	13-acetate	47-57	AKT serine/threonine kinase 1	Homo sapiens	216-219
24486723-8	2014	In addition, MED significantly inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced CCA cells invasion in a dose-dependent manner by reducing the expression of matrix metalloelastase 9 (MMP-9).	13-acetate	67-77	matrix metallopeptidase 9	Homo sapiens	194-199