PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 8003498-3 1994 Upon Ca2+ crenation of cells, surface exposure of phosphatidylserine and phosphatidylethanolamine was observed simultaneously with inward diffusion of phosphatidylcholine. phosphatidylethanolamine 73-97 carbonic anhydrase 2 Homo sapiens 5-8 7943660-4 1994 Phosphatidylethanolamine N-methyltransferase activity was measured in sequential percutaneous needle liver biopsies by the conversion of phosphatidylethanolamine to phosphatidylcholine, using radioactive S-adenosylmethionine as a methyl donor. phosphatidylethanolamine 137-161 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-44 8020468-7 1994 Purified NOR contained cardiolipin, phosphatidylglycerol, and phosphatidylethanolamine, the latter as the major component. phosphatidylethanolamine 62-86 cbb3-type cytochrome c oxidase subunit I Pseudomonas stutzeri 9-12 8189063-5 1994 The bulk of AA released by sPLA2 is derived from phosphatidylethanolamine. phosphatidylethanolamine 49-73 phospholipase A2, group IIA (platelets, synovial fluid) Mus musculus 27-32 8185671-2 1994 In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990). phosphatidylethanolamine 152-176 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-84 7754559-4 1994 The maximum arachidonate release in 6h following 1 Gy irradiation correlates with activation of more active phospholipase A2, hydrolyzing PE. phosphatidylethanolamine 138-140 phospholipase A2 group IB Rattus norvegicus 108-124 8185671-2 1994 In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990). phosphatidylethanolamine 152-176 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 86-89 8185671-2 1994 In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990). phosphatidylethanolamine 178-184 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-84 8185671-2 1994 In NIH 3T3 fibroblasts, sphingosine has also been shown to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) (Kiss Z and Anderson WB, J Biol Chem 265: 7345-7350, 1990). phosphatidylethanolamine 178-184 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 86-89 8178956-1 1994 Previous studies suggest that signal transduction mediated by interleukin-1 (IL-1), acting through an IL-1 receptor type found on T-cells and mesangial cells, may use phosphatidylethanolamine (PE) as a signaling molecule. phosphatidylethanolamine 167-191 interleukin 1 alpha Homo sapiens 62-75 8178956-1 1994 Previous studies suggest that signal transduction mediated by interleukin-1 (IL-1), acting through an IL-1 receptor type found on T-cells and mesangial cells, may use phosphatidylethanolamine (PE) as a signaling molecule. phosphatidylethanolamine 167-191 interleukin 1 alpha Homo sapiens 77-81 8178956-1 1994 Previous studies suggest that signal transduction mediated by interleukin-1 (IL-1), acting through an IL-1 receptor type found on T-cells and mesangial cells, may use phosphatidylethanolamine (PE) as a signaling molecule. phosphatidylethanolamine 167-191 interleukin 1 alpha Homo sapiens 102-106 8178956-1 1994 Previous studies suggest that signal transduction mediated by interleukin-1 (IL-1), acting through an IL-1 receptor type found on T-cells and mesangial cells, may use phosphatidylethanolamine (PE) as a signaling molecule. phosphatidylethanolamine 193-195 interleukin 1 alpha Homo sapiens 62-75 8178956-1 1994 Previous studies suggest that signal transduction mediated by interleukin-1 (IL-1), acting through an IL-1 receptor type found on T-cells and mesangial cells, may use phosphatidylethanolamine (PE) as a signaling molecule. phosphatidylethanolamine 193-195 interleukin 1 alpha Homo sapiens 77-81 8178956-1 1994 Previous studies suggest that signal transduction mediated by interleukin-1 (IL-1), acting through an IL-1 receptor type found on T-cells and mesangial cells, may use phosphatidylethanolamine (PE) as a signaling molecule. phosphatidylethanolamine 193-195 interleukin 1 alpha Homo sapiens 102-106 8178956-2 1994 Evidence presented here indicates that stimulation of human mesangial cells by IL-1 results in activation of a phospholipase D (PLD) that hydrolyzes PE to phosphatidic acid (PA). phosphatidylethanolamine 149-151 interleukin 1 alpha Homo sapiens 79-83 8178956-2 1994 Evidence presented here indicates that stimulation of human mesangial cells by IL-1 results in activation of a phospholipase D (PLD) that hydrolyzes PE to phosphatidic acid (PA). phosphatidylethanolamine 149-151 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 111-126 8178956-2 1994 Evidence presented here indicates that stimulation of human mesangial cells by IL-1 results in activation of a phospholipase D (PLD) that hydrolyzes PE to phosphatidic acid (PA). phosphatidylethanolamine 149-151 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 128-131 8178956-3 1994 PLD acts on a subfraction of PE enriched in 1-o-alkyl and 1-o-alkenyl, sn-2-unsaturated species, generating a unique PA subspecies 30-120 s after stimulation. phosphatidylethanolamine 29-31 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 8207329-6 1994 Methylation of PE in the rat retinal sonicates was assayed using 3H-SAM (2 microM) at 37 degrees C in Tris-glycylglycine buffer (50 mM, pH 8.0) and methylated phospholipids were extracted with chloroform/methanol/HCl (2/1/0.02, v/v) and separated by thin layer chromatography on Silica Gel G plates. phosphatidylethanolamine 15-17 Hepatic cholesterol level QTL 1 Rattus norvegicus 213-226 8166664-3 1994 The 110 kDa phospholipase A2 was much more active with phosphatidylethanolamine and was not affected by glycosaminoglycans, whereas the 39 kDa phospholipase A2 was much more active with ethanolamine plasmalogen and was markedly inhibited by glycosaminoglycans. phosphatidylethanolamine 55-79 LOC104974671 Bos taurus 12-28 8194157-4 1994 In PC-PE mixtures with high content of PE the phase transitions shown by APC and APE were broader than those recorded by DPH. phosphatidylethanolamine 6-8 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 81-84 7921783-4 1994 Phosphatidylglycerol, phosphatidylserine, phosphatidylinositol and phosphatidylethanolamine served as specific activators of plasma membrane-bound phospholipase C when PIP, PIP2 and PC were used as substrates. phosphatidylethanolamine 67-91 prolactin induced protein Rattus norvegicus 168-171 8171289-0 1994 Hydrolysis of phosphatidylethanolamine by human pancreatic phospholipase A2. phosphatidylethanolamine 14-38 phospholipase A2 group IB Homo sapiens 59-75 8125158-8 1994 Both type I collagen and laminin substrates containing heparin-PE bound higher amounts of HGF than the respective control substrates, whereas neither of the substrates containing chondroitin sulfate-PE did. phosphatidylethanolamine 63-65 hepatocyte growth factor Rattus norvegicus 90-93 8314349-4 1994 Reconstituted membranes containing muramyl tripeptide phosphatidylethanolamine (MTP-PE) provided better protection against a challenge with SL2 cells than did reconstituted membranes containing alternative immunomodulators. phosphatidylethanolamine 54-78 matrix metallopeptidase 10 Mus musculus 140-143 7508929-6 1994 When the PKC activities with vesicles of varying phosphatidylcholine unsaturation, with and without phosphatidylethanolamine, were plotted as a function of the fluorescence intensity of C6-NBD-PC-labeled vesicles, a biphasic profile was obtained, which had an optimum value of intensity, relating to head group spacing, that corresponded to a maximal enzyme activity. phosphatidylethanolamine 100-124 protein kinase C, gamma Rattus norvegicus 9-12 8171289-2 1994 The 2-ester bond of 14C-2-arachidonyl phosphatidylethanolamine (PE) was hydrolyzed faster than that of 3H-2-arachidonyl phosphatidylcholine (PC) by human pancreatic phospholipase A2 (PLA2) with mixed PE-PC (1:9 w/w) liposomes of pure sonicated PE or PC as substrate. phosphatidylethanolamine 64-66 phospholipase A2 group IB Homo sapiens 165-181 8171289-2 1994 The 2-ester bond of 14C-2-arachidonyl phosphatidylethanolamine (PE) was hydrolyzed faster than that of 3H-2-arachidonyl phosphatidylcholine (PC) by human pancreatic phospholipase A2 (PLA2) with mixed PE-PC (1:9 w/w) liposomes of pure sonicated PE or PC as substrate. phosphatidylethanolamine 64-66 phospholipase A2 group IB Homo sapiens 183-187 8280752-4 1994 This abnormality limits the patients" capacity to convert phosphatidylethanolamine to phosphatidylcholine by way of phosphatidylethanolamine-N-methyltransferase (PEMT). phosphatidylethanolamine 58-82 phosphatidylethanolamine N-methyltransferase Homo sapiens 116-160 8280752-4 1994 This abnormality limits the patients" capacity to convert phosphatidylethanolamine to phosphatidylcholine by way of phosphatidylethanolamine-N-methyltransferase (PEMT). phosphatidylethanolamine 58-82 phosphatidylethanolamine N-methyltransferase Homo sapiens 162-166 8304484-9 1994 Phosphatidylethanolamine was the preferred substrate for ET-mediated activation of phospholipase A2 (PLA2). phosphatidylethanolamine 0-24 phospholipase A2 group IB Rattus norvegicus 83-99 8304484-9 1994 Phosphatidylethanolamine was the preferred substrate for ET-mediated activation of phospholipase A2 (PLA2). phosphatidylethanolamine 0-24 phospholipase A2 group IB Rattus norvegicus 101-105 7917546-0 1994 Phase II study of liposomal muramyl tripeptide phosphatidylethanolamine (MTP/PE) in advanced soft tissue sarcomas of the adult. phosphatidylethanolamine 47-71 metallothionein 1B Homo sapiens 73-76 7719380-0 1994 Induction of serum tumor necrosis factor-alpha and interleukin-6 activity by liposome-encapsulated muramyl tripeptide-phosphatidylethanolamine (L-MTP-PE) in normal cats. phosphatidylethanolamine 118-142 tumor necrosis factor Felis catus 19-46 7719380-0 1994 Induction of serum tumor necrosis factor-alpha and interleukin-6 activity by liposome-encapsulated muramyl tripeptide-phosphatidylethanolamine (L-MTP-PE) in normal cats. phosphatidylethanolamine 118-142 interleukin 6 Felis catus 51-64 7917546-2 1994 The EORTC Soft Tissue and Bone Sarcoma Group conducted a phase II study with intravenous muramyl tripeptide phosphatidylethanolamine (MTP/PE) at a dose of 4 mg once weekly in 20 patients with metastatic soft tissue sarcomas. phosphatidylethanolamine 108-132 metallothionein 1B Homo sapiens 134-137 8138721-0 1994 Synthesis of photoreactive phosphatidylethanolamine and its interaction with phospholipase A2. phosphatidylethanolamine 27-51 phospholipase A2 group IB Homo sapiens 77-93 12369753-6 1994 The ratio between saturated and unsaturated fatty acids (saturation index) decreased in the total microsomes and phospholipids with PCB treatment, whereas MC did not alter the ratio, except that the major effect of MC was observed in the acyl derivatives of microsomal phosphatidylethanolamine. phosphatidylethanolamine 269-293 pyruvate carboxylase Rattus norvegicus 132-135 8128456-9 1993 Secreted phospholipase A2 hydrolyzed phosphatidylethanolamine at 5-12 times the rate of phosphatidylcholine when the substrates were present in pure form. phosphatidylethanolamine 37-61 phospholipase A2 group IB Homo sapiens 9-25 8457575-5 1993 The maximum fraction of spin-labeled phospholipids translocated to the inner membrane layer was 84% for phosphatidylserine, 65% for phosphatidylethanolamine, 20-40% for phosphatidylcholine, and below 20% for sphingomyelin. phosphatidylethanolamine 132-156 spindlin 1 Homo sapiens 24-28 8302756-9 1993 Initial studies concerning induction of protective tumor immunity by immunization with reconstituted membranes with muramyl tripeptide phosphatidylethanolamine indicate that coinjection of IL-2-containing liposomes provided a significant enhancement of the immune response. phosphatidylethanolamine 135-159 interleukin 2 Homo sapiens 189-193 8251517-1 1993 Purified adrenocortical microsomal P-450C21 was incorporated into vesicle membranes composed of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine at a molar ratio of 5:3:1. phosphatidylethanolamine 117-141 steroid 21-hydroxylase Bos taurus 35-43 8218351-3 1993 PLA2 enzymatic activity present in the same tissues averaged 1.3 +/- 0.2 and 1.9 +/- 0.7 nmol phosphatidylethanolamine (PE) hydrolysed/mg tissue protein per h (n = 3), respectively. phosphatidylethanolamine 94-118 phospholipase A2 group IIA Homo sapiens 0-4 8218351-3 1993 PLA2 enzymatic activity present in the same tissues averaged 1.3 +/- 0.2 and 1.9 +/- 0.7 nmol phosphatidylethanolamine (PE) hydrolysed/mg tissue protein per h (n = 3), respectively. phosphatidylethanolamine 120-122 phospholipase A2 group IIA Homo sapiens 0-4 7508272-10 1993 The human serum phospholipase A2 strongly preferred E. coli membranes as substrate to the mixed micelles containing phosphatidylcholine/phosphatidylethanolamine. phosphatidylethanolamine 136-160 phospholipase A2 group IB Homo sapiens 16-32 8224184-0 1993 Overexpression of protein kinase C-epsilon enhances the stimulatory effect of ethanol on phospholipase C-mediated hydrolysis of phosphatidylethanolamine in NIH 3T3 fibroblasts. phosphatidylethanolamine 128-152 protein kinase C epsilon Homo sapiens 18-42 8224184-1 1993 Previously, ethanol and the protein kinase C (PKC) activators phorbol 12-myristate 13-acetate (PMA) and bombesin were shown to synergistically stimulate phospholipase C (PLC)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn) in NIH 3T3 fibroblasts. phosphatidylethanolamine 198-222 protein kinase C epsilon Homo sapiens 46-49 8224184-1 1993 Previously, ethanol and the protein kinase C (PKC) activators phorbol 12-myristate 13-acetate (PMA) and bombesin were shown to synergistically stimulate phospholipase C (PLC)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn) in NIH 3T3 fibroblasts. phosphatidylethanolamine 224-230 protein kinase C epsilon Homo sapiens 46-49 8387269-5 1993 With PLA2 the concentration of phosphatidylethanolamine, as well as of phosphatidylcholine, was significantly decreased. phosphatidylethanolamine 31-55 phospholipase A2 group IB Rattus norvegicus 5-9 8167224-6 1994 PLA2 enzymatic activity average 29.8 +/- 5.1 pmol phosphatidylethanolamine (PE)/mg DNA/h. phosphatidylethanolamine 50-74 phospholipase A2 group IB Homo sapiens 0-4 8167224-6 1994 PLA2 enzymatic activity average 29.8 +/- 5.1 pmol phosphatidylethanolamine (PE)/mg DNA/h. phosphatidylethanolamine 76-78 phospholipase A2 group IB Homo sapiens 0-4 7692845-3 1993 Phosphatidylcholine, lysophosphatidylcholine, and phosphatidylethanolamine dose-dependently enhanced the enzyme activity up to 3 fold in the presence of Ca2+, calmodulin, NADPH, FAD, and (6R)-5,6,7,8-tetrahydrobiopterin. phosphatidylethanolamine 50-74 calmodulin Bos taurus 159-169 8399135-1 1993 Monoclonal antibodies (mAbs) directed against E2, a 32-kDa transmembrane protein encoded by the MIC2 gene located in the pseudoautosomal region, induce a transbilayer movement of phosphatidylserine and, to a lesser extent, phosphatidylethanolamine in human thymocytes and a Jurkat T lymphocytes. phosphatidylethanolamine 223-247 CD99 molecule (Xg blood group) Homo sapiens 96-100 8403234-10 1993 Although the PL composition of the cells remained essentially unaffected, our study shows that chronic treatment of U937 cells with n - 3 PUFA (20:5) depressed PC and PE synthesis, and 18:3 and 20:4 also caused inhibition of PE synthesis. phosphatidylethanolamine 167-169 pumilio RNA binding family member 3 Homo sapiens 138-142 8403234-10 1993 Although the PL composition of the cells remained essentially unaffected, our study shows that chronic treatment of U937 cells with n - 3 PUFA (20:5) depressed PC and PE synthesis, and 18:3 and 20:4 also caused inhibition of PE synthesis. phosphatidylethanolamine 225-227 pumilio RNA binding family member 3 Homo sapiens 138-142 8231655-1 1993 The modulation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) biosynthesis by sulfur-substituted fatty acid analogues has been investigated in rats. phosphatidylethanolamine 47-71 procollagen C-endopeptidase enhancer Rattus norvegicus 73-75 8344945-2 1993 Phosphatidylethanolamine N-methyltransferase catalyzes the synthesis of phosphatidylcholine from phosphatidylethanolamine and is most active in liver. phosphatidylethanolamine 97-121 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 0-44 8334682-1 1993 The purpose of this study was to examine the mechanisms by which liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (L-MTP-PE) stimulates monocytes to produce tumor necrosis factor (TNF) and interleukin-1 (IL-1). phosphatidylethanolamine 106-130 tumor necrosis factor Homo sapiens 174-195 8334682-1 1993 The purpose of this study was to examine the mechanisms by which liposome-encapsulated muramyl tripeptide phosphatidylethanolamine (L-MTP-PE) stimulates monocytes to produce tumor necrosis factor (TNF) and interleukin-1 (IL-1). phosphatidylethanolamine 106-130 tumor necrosis factor Homo sapiens 197-200 8405660-4 1993 Synaptic plasma membrane vesicles (SPMV) from rat brain synthesized ceramide-phosphoethanolamine (SpE), an analogue of sphingomyelin (SpC) from phosphatidylethanolamine (PE) and ceramide. phosphatidylethanolamine 144-168 surfactant protein C Rattus norvegicus 134-137 8393878-3 1993 Thus, other signal transduction pathways that hydrolyze phosphatidylcholine (PtdCho) or phosphatidylethanolamine (PtdEth) and form DG and phosphatidic acids (PA) through either PLC or phospholipase D (PLD) may also mediate PAF-stimulated cellular responses. phosphatidylethanolamine 88-112 PCNA clamp associated factor Rattus norvegicus 223-226 7686929-5 1993 Moreover, in these conditions, K20 increased phosphatidylethanolamine levels, without variation of phosphatidylcholine, phosphatidylserine, and phosphatidylinositol, suggesting that K20 specifically increased the phosphatidylethanolamine biosynthesis from DAG. phosphatidylethanolamine 45-69 keratin 20 Homo sapiens 31-34 7686929-5 1993 Moreover, in these conditions, K20 increased phosphatidylethanolamine levels, without variation of phosphatidylcholine, phosphatidylserine, and phosphatidylinositol, suggesting that K20 specifically increased the phosphatidylethanolamine biosynthesis from DAG. phosphatidylethanolamine 213-237 keratin 20 Homo sapiens 31-34 7686929-5 1993 Moreover, in these conditions, K20 increased phosphatidylethanolamine levels, without variation of phosphatidylcholine, phosphatidylserine, and phosphatidylinositol, suggesting that K20 specifically increased the phosphatidylethanolamine biosynthesis from DAG. phosphatidylethanolamine 213-237 keratin 20 Homo sapiens 182-185 8504157-8 1993 The PA synthesis caused by the two stimulators was similarly inhibited by staurosporine and by a chronic treatment with PMA (100 nM for 24 h), suggesting that the activation of PLD is linked to the action of protein kinase C. With the cells labeled with radioactive choline and ethanolamine, we found that the amniotic PLD hydrolyzed almost equally phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 373-397 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 177-180 8499439-7 1993 These endogenous islet plasmenylethanolamine species are hydrolyzed more rapidly than phosphatidylethanolamine species by islet ASCI-PLA2 in vitro and are also hydrolyzed in intact islets stimulated with secretagogues. phosphatidylethanolamine 86-110 phospholipase A2 group IIA Homo sapiens 133-137 8387776-2 1993 PLC delta bound weakly to vesicles composed of phosphatidylserine (PS) or phosphatidylcholine (PC) or phosphatidylethanolamine (PE) + PC, and even more weakly to vesicles composed of phosphatidylinositol. phosphatidylethanolamine 102-126 phospholipase C delta 1 Homo sapiens 0-9 8387776-2 1993 PLC delta bound weakly to vesicles composed of phosphatidylserine (PS) or phosphatidylcholine (PC) or phosphatidylethanolamine (PE) + PC, and even more weakly to vesicles composed of phosphatidylinositol. phosphatidylethanolamine 128-130 phospholipase C delta 1 Homo sapiens 0-9 8387776-5 1993 When LUVs composed of PE + PC + PIP2 (molar ratio of 79:20:1) were tested as a function of increasing phospholipid concentration, 50% binding of PLC delta occurred at 1.2 nmol/ml PIP2 and 120 nmol/ml total phospholipid. phosphatidylethanolamine 22-24 phospholipase C delta 1 Homo sapiens 145-154 8387776-9 1993 When LUVs composed of PE + PC + SM (molar ratio 48:12:40) were tested as a function of increasing phospholipid concentration, 50% binding of PLC delta occurred at a level of 96 nmol/ml SM. phosphatidylethanolamine 22-24 phospholipase C delta 1 Homo sapiens 141-150 8491183-6 1993 To test the possibility that PE is the immediate donor of the GPI phosphoethanolamine moiety, we describe metabolic labelling experiments with [3H]serine and show that GPIs can be labelled in the absence of detectable radiolabelled CDP-ethanolamine, presumably via [3H]PE generated from [3H]phosphatidylserine (PS). phosphatidylethanolamine 29-31 cut like homeobox 1 Homo sapiens 232-235 8457575-4 1993 Spin-labeled aminophospholipids (phosphatidylserine and phosphatidylethanolamine) were translocated to the inner vesicle membrane layer at a comparable rate as in intact red cells provided that vesicles contained enough ATP. phosphatidylethanolamine 56-80 spindlin 1 Homo sapiens 0-4 8457575-6 1993 The apparent Km of translocation, expressed as percent of total membrane phospholipid, was 0.14% for spin-labeled phosphatidylserine and 1.19% for spin-labeled phosphatidylethanolamine. phosphatidylethanolamine 160-184 spindlin 1 Homo sapiens 147-151 8443184-7 1993 The recombinants of rhodopsin with egg PC, either alone or in combination with egg PC-derived phosphatidylethanolamine (PE) or phosphatidylserine (PS), exhibited substantially reduced photochemical activity at pH 7.0. phosphatidylethanolamine 94-118 rhodopsin Bos taurus 20-29 8443184-7 1993 The recombinants of rhodopsin with egg PC, either alone or in combination with egg PC-derived phosphatidylethanolamine (PE) or phosphatidylserine (PS), exhibited substantially reduced photochemical activity at pH 7.0. phosphatidylethanolamine 120-122 rhodopsin Bos taurus 20-29 8431458-3 1993 L-FABP expression altered plasma membrane phospholipids by decreasing both phosphatidylethanolamine and esterified oleic acid content, and increasing sphingomyelin. phosphatidylethanolamine 75-99 fatty acid binding protein 1 Homo sapiens 0-6 8464355-0 1993 Simultaneous determination of the main molecular species of soybean phosphatidylcholine or phosphatidylethanolamine and their corresponding hydroperoxides obtained by lipoxygenase treatment. phosphatidylethanolamine 91-115 linoleate 9S-lipoxygenase-4 Glycine max 167-179 8274032-3 1993 The isolated fractions of phosphatidylcholine (PC), phosphatidylinositol (PI) and phosphatidyl-ethanolamine (PE) were treated with phospholipase A2 to release fatty acids in the sn-2 position. phosphatidylethanolamine 82-107 phospholipase A2 group IB Homo sapiens 131-147 8431204-6 1993 RESULTS: Stimulation of synovial cells with recombinant IL-1 beta induced a decrease in phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE), and a marked increase in cell-associated PLA2 activity as compared with controls. phosphatidylethanolamine 145-169 interleukin 1 beta Homo sapiens 56-65 8431204-6 1993 RESULTS: Stimulation of synovial cells with recombinant IL-1 beta induced a decrease in phosphatidylcholine (PC), phosphatidylinositol (PI), and phosphatidylethanolamine (PE), and a marked increase in cell-associated PLA2 activity as compared with controls. phosphatidylethanolamine 171-173 interleukin 1 beta Homo sapiens 56-65 8431204-10 1993 Addition of quinacrine was also demonstrated to abolish the IL-1-induced hydrolysis of PC and PE but not PI, indicating that PC and PE are the preferred substrates for PLA2 enzymatic activity in human synovial cells. phosphatidylethanolamine 94-96 phospholipase A2 group IB Homo sapiens 168-172 8274032-3 1993 The isolated fractions of phosphatidylcholine (PC), phosphatidylinositol (PI) and phosphatidyl-ethanolamine (PE) were treated with phospholipase A2 to release fatty acids in the sn-2 position. phosphatidylethanolamine 109-111 phospholipase A2 group IB Homo sapiens 131-147 1477209-7 1992 MTP also showed phosphatidylethanolamine-binding activity (Kd = 1.95 x 10(-5) M, Bmax = 1.86 nmol/micrograms MTP), suggesting that the mouse 25-kDa protein is a member of the phospholipid-binding protein family and may have a role in lipid metabolism during sperm maturation. phosphatidylethanolamine 16-40 lysosomal-associated protein transmembrane 4A Mus musculus 0-3 1472000-1 1992 Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss & Anderson (1990) J. Biol. phosphatidylethanolamine 134-158 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-99 1472000-1 1992 Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss & Anderson (1990) J. Biol. phosphatidylethanolamine 134-158 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 1472000-1 1992 Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss & Anderson (1990) J. Biol. phosphatidylethanolamine 160-166 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-99 1472000-1 1992 Previously, the protein kinase C (PKC) inhibitor sphingosine was found to stimulate phospholipase D (PLD)-mediated hydrolysis of both phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) in NIH 3T3 fibroblasts [Kiss & Anderson (1990) J. Biol. phosphatidylethanolamine 160-166 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 101-104 1333282-4 1992 The rate of incorporation of CMP into CDP-choline and CDP-ethanolamine was increased by increasing the concentration of phosphatidylcholine and phosphatidylethanolamine, respectively, in detergent-phospholipid micellar systems. phosphatidylethanolamine 144-168 cut-like homeobox 1 Rattus norvegicus 38-41 1333282-4 1992 The rate of incorporation of CMP into CDP-choline and CDP-ethanolamine was increased by increasing the concentration of phosphatidylcholine and phosphatidylethanolamine, respectively, in detergent-phospholipid micellar systems. phosphatidylethanolamine 144-168 cut-like homeobox 1 Rattus norvegicus 54-57 1444461-9 1992 The three alpha-class GSTs of lung expressed glutathione peroxidase activities toward the hydroperoxides of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylglycerol, with Km values in the range of 22 to 87 microM and Vmax values in the range of 67-120 mol/mol/min, indicating the involvement of the alpha-class GSTs in the protection mechanisms against peroxidation. phosphatidylethanolamine 129-153 glutathione S-transferase kappa 1 Homo sapiens 22-26 8445336-0 1993 Metabolism of molecular species of phosphatidylethanolamine and phosphatidylcholine in rat hepatocytes during prolonged inhibition of phosphatidylethanolamine N-methyltransferase. phosphatidylethanolamine 35-59 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 134-178 1482699-0 1992 Cooperative effects of ethanol and protein kinase C activators on phospholipase-D-mediated hydrolysis of phosphatidylethanolamine in NIH 3T3 fibroblasts. phosphatidylethanolamine 105-129 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 66-81 1482699-1 1992 In a previous study, ethanol was shown to enhance the stimulatory effect of phorbol 12-myristate 13-acetate (PMA), a prominent activator of protein kinase C (PKC), on phospholipase-D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn) in NIH 3T3 fibroblasts (Kiss et al. phosphatidylethanolamine 212-236 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 167-182 1482699-1 1992 In a previous study, ethanol was shown to enhance the stimulatory effect of phorbol 12-myristate 13-acetate (PMA), a prominent activator of protein kinase C (PKC), on phospholipase-D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn) in NIH 3T3 fibroblasts (Kiss et al. phosphatidylethanolamine 238-244 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 167-182 1493107-1 1992 Incubation of murine macrophages or the macrophage-like cell line P388D with interferon-gamma in vitro induced a significant increase in the polyunsaturated fatty acid content of phosphatidylethanolamine. phosphatidylethanolamine 179-203 interferon gamma Mus musculus 77-93 1480148-7 1992 Although the changes in proportion of these long-chain PUFA"s in cardiac phosphatidyl ethanolamine and phosphatidyl inositol are not identical, the shift in balance between these substrates or inhibitors of cyclo-oxygenase activity leads to relatively greater production of prostacyclin (PGI2) than thromboxane (TXA2). phosphatidylethanolamine 73-98 pumilio RNA binding family member 3 Homo sapiens 55-59 1289236-6 1992 The presence of phosphatidylcholine and phosphatidylethanolamine in the culture medium also increased the secretion of apoB into the medium. phosphatidylethanolamine 40-64 apolipoprotein B Rattus norvegicus 119-123 1327780-4 1992 TPA, bryostatin, and bombesin, direct or indirect activators of PKC, had similar potentiating effects on ethanol-induced formation of [14C]ethanolamine phosphate from [14C]PtdEtn in [14C]ethanolamine-prelabelled NIH 3T3 fibroblasts. phosphatidylethanolamine 172-178 gastrin releasing peptide Homo sapiens 21-29 1304354-11 1992 Changing the vesicle composition to phosphatidylethanolamine in place of PC gave higher affinity and decreased dissociation of the 32-kDa protein and SAP. phosphatidylethanolamine 36-60 amyloid P component, serum Homo sapiens 150-153 1497353-3 1992 Phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI) also inhibit PLC delta in the presence of spermine but are much less effective than SM. phosphatidylethanolamine 0-24 heparan sulfate proteoglycan 2 Homo sapiens 125-128 1497353-3 1992 Phosphatidylethanolamine (PE), phosphatidylcholine (PC), phosphatidylserine (PS), and phosphatidylinositol (PI) also inhibit PLC delta in the presence of spermine but are much less effective than SM. phosphatidylethanolamine 26-28 heparan sulfate proteoglycan 2 Homo sapiens 125-128 1403582-5 1992 We found that phosphatidylethanolamine, rather than phosphatidylcholine, was the preferred substrate, the Ca2+ ion was essential for the expression of PLA2 activity, the enzyme was active over a broad pH range, with the optimum at pH 9.0, and sodium-deoxycholate inhibited the enzyme activity strongly in a concentration-dependent manner. phosphatidylethanolamine 14-38 phospholipase A2 group IB Rattus norvegicus 151-155 1510717-6 1992 Studies have shown that IL-1 does not activate the IP pathway, but it primarily stimulates a PLC linked to phosphatidylethanolamine in cultured rat mesangial cells, and a PLC linked to PC in Jurkart cells. phosphatidylethanolamine 107-131 interleukin 1 alpha Homo sapiens 24-28 1322394-3 1992 Using yeast mutants generated by disruption of the ethanolaminephosphotransferase (EPT1) and cholinephosphotransferase (CPT1) genes, we report data consistent with the proposal that the ethanolamine residue is derived from phosphatidylethanolamine. phosphatidylethanolamine 223-247 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 83-87 1322394-3 1992 Using yeast mutants generated by disruption of the ethanolaminephosphotransferase (EPT1) and cholinephosphotransferase (CPT1) genes, we report data consistent with the proposal that the ethanolamine residue is derived from phosphatidylethanolamine. phosphatidylethanolamine 223-247 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 120-124 1643097-0 1992 Peroxidation and phospholipase A2 hydrolytic susceptibility of liposomes consisting of mixed species of phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 128-152 LOC104974671 Bos taurus 17-33 1637304-0 1992 Differential effects of platelet-derived growth factor, serum and bombesin on phospholipase D-mediated hydrolysis of phosphatidylethanolamine in NIH 3T3 fibroblasts. phosphatidylethanolamine 117-141 gastrin releasing peptide Homo sapiens 66-74 1637304-2 1992 Here I examined possible stimulation of PtdEtn hydrolysis by various growth-stimulatory agents, including serum, bombesin, platelet-derived growth factor (PDGF), fibroblast growth factor (FGF) and insulin. phosphatidylethanolamine 40-46 gastrin releasing peptide Homo sapiens 113-121 1637304-2 1992 Here I examined possible stimulation of PtdEtn hydrolysis by various growth-stimulatory agents, including serum, bombesin, platelet-derived growth factor (PDGF), fibroblast growth factor (FGF) and insulin. phosphatidylethanolamine 40-46 insulin Homo sapiens 197-204 1533622-5 1992 Phospholipid binding studies showed that CAP-50 bound to phosphatidylserine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidic acid-containing vesicles, in a Ca(2+)-dependent manner. phosphatidylethanolamine 77-101 annexin A11 Oryctolagus cuniculus 41-47 1533163-1 1992 The selectivity of phospholipase A2 from serum was evaluated using radioassays and mass analyses of fatty acids liberated from phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 151-175 phospholipase A2 group IB Homo sapiens 19-35 1390631-4 1992 The lack of significant energy transfer (less than 5%) from FAD+FMN to the rhodamine group of the N-labeled phosphatidylethanolamine incorporated in membranes reconstituted with NADPH-cytochrome P450 reductase and phosphatidylcholine points out that both groups are located at a distance greater than 5 nm from the lipid/water interphase. phosphatidylethanolamine 108-132 cytochrome p450 oxidoreductase Homo sapiens 178-209 1382549-4 1992 Using a lipid-based solid-phase radioimmunoassay, the MAbs interacted with both anionic phospholipids and phosphatidylethanolamine, but not phosphatidylcholine, in a beta 2GPI-dependent manner. phosphatidylethanolamine 106-130 apolipoprotein H Homo sapiens 166-175 1623560-8 1992 Incorporation of arachidonic acid into phosphatidylinositol and serine into phosphatidylethanolamine was also increased in the interferon-gamma-activated monocytes. phosphatidylethanolamine 76-100 interferon gamma Homo sapiens 127-143 1377689-2 1992 Carbohydrate recognition by the human endothelial-leukocyte adhesion molecule, E-selectin, has been investigated by binding studies using 3H-labeled Chinese hamster ovary cells expressing different levels of the transfected full-length adhesion molecule and a series of structurally defined oligosaccharides linked to the lipid phosphatidylethanolamine dipalmitoate (neoglycolipids) and synthetic glycolipids chromatographed on silica gel plates or immobilized on plastic wells. phosphatidylethanolamine 328-352 selectin E Homo sapiens 79-89 1612188-2 1992 Human seminal plasma and posterior lobe of prostate was found to have phospholipase A2 (PLA2) activity hydrolysing phosphatidylethanolamine with 14C-labelled linoleic and arachidonic acid. phosphatidylethanolamine 115-139 phospholipase A2 group IB Homo sapiens 70-86 1612188-2 1992 Human seminal plasma and posterior lobe of prostate was found to have phospholipase A2 (PLA2) activity hydrolysing phosphatidylethanolamine with 14C-labelled linoleic and arachidonic acid. phosphatidylethanolamine 115-139 phospholipase A2 group IB Homo sapiens 88-92 1577781-7 1992 AOAH also catalyzes acyl transfer from LPS and phosphatidylethanolamine to acceptor lipids; approximately equal amounts of laurate and myristate are transferred from LPS to monooleoylglyceryl ether, forming acyloleoylglyceryl ether. phosphatidylethanolamine 47-71 acyloxyacyl hydrolase Homo sapiens 0-4 1558154-3 1992 PLA2 activity was measured by estimating the amount of sn-2 fatty acid released from either 14C-labeled Escherichia coli membranes or [14C]phosphatidylethanolamine (PE) micelles incubated with membrane and cytosolic fractions obtained from normoxic or anoxic tubules. phosphatidylethanolamine 139-163 phospholipase A2 Oryctolagus cuniculus 0-4 1577722-3 1992 At the same time the secretion of group II phospholipase A2, measured both as enzyme activity with sn-2-labeled phosphatidylethanolamine as substrate and as enzyme protein in immunoblot experiments, is dose-dependently inhibited by pretreatment of the cells with transforming growth factor-beta 2. phosphatidylethanolamine 112-136 phospholipase A2 group IB Rattus norvegicus 43-59 1643252-10 1992 Fatty acid analysis, 19F and 31P NMR spectroscopy, and mass spectrometric analyses confirmed that the major TFEC and CTFC adducts are thioamides of phosphatidylethanolamine. phosphatidylethanolamine 148-172 transcription factor EC Rattus norvegicus 108-112 1312955-0 1992 Influence of phospholipid environment on the phosphatidylethanolamine: ceramide-phosphorylethanolamine transferase activity in rat liver plasma membranes. phosphatidylethanolamine 45-69 phosphate cytidylyltransferase 2, ethanolamine Rattus norvegicus 80-114 1312955-7 1992 The activity of phosphatidylethanolamine:ceramide-phosphorylethanolamine transferase was not influenced by the fluidity of its lipid environment. phosphatidylethanolamine 16-40 phosphate cytidylyltransferase 2, ethanolamine Rattus norvegicus 50-84 1569041-1 1992 Phospholipase A2 activity in lysates of mast cells such as rat mastocytoma RBL-2H3 cells and mouse bone marrow-derived IL-3-dependent mast cells (BMMC) was measured using phosphatidylcholine (PC), phosphatidylethanolamine (PE), or phosphatidylserine (PS) as a substrate. phosphatidylethanolamine 197-221 phospholipase A2 group IB Rattus norvegicus 0-16 1569041-1 1992 Phospholipase A2 activity in lysates of mast cells such as rat mastocytoma RBL-2H3 cells and mouse bone marrow-derived IL-3-dependent mast cells (BMMC) was measured using phosphatidylcholine (PC), phosphatidylethanolamine (PE), or phosphatidylserine (PS) as a substrate. phosphatidylethanolamine 223-225 phospholipase A2 group IB Rattus norvegicus 0-16 1569050-6 1992 This isoform showed a distinctly lower Ca(2+)-requirement (3 microM) than that of PKC alpha or beta (100 microM) and was more dependent on cardiolipin and phosphatidylethanolamine, compared with PKC alpha, beta, and gamma. phosphatidylethanolamine 155-179 protein kinase C alpha Homo sapiens 82-91 1576245-6 1992 The data indicate that the parenteral administration of liposomes containing the aminophospholipids phosphatidylserine, and phosphatidylethanolamine is an efficient mode to reduce the endotoxin-induced production of TNF. phosphatidylethanolamine 124-148 tumor necrosis factor Mus musculus 216-219 1636497-1 1992 Phospholipase A2 activity in lysates of mast cells and their related cells [mouse bone marrow-derived IL-3 dependent mast cells (BMMC), rat connective tissue mast cells (CTMC), and rat mastocytoma RBL-2H3 cells] was measured using phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylcholine (PC) as exogenous substrates. phosphatidylethanolamine 231-255 phospholipase A2, group IB, pancreas Mus musculus 0-16 1636497-1 1992 Phospholipase A2 activity in lysates of mast cells and their related cells [mouse bone marrow-derived IL-3 dependent mast cells (BMMC), rat connective tissue mast cells (CTMC), and rat mastocytoma RBL-2H3 cells] was measured using phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylcholine (PC) as exogenous substrates. phosphatidylethanolamine 257-259 phospholipase A2, group IB, pancreas Mus musculus 0-16 1548189-7 1992 Comparison with duramycin, another phospholipase A2 inhibitor, displayed inhibition dependent on substrate concentration when phosphatidylethanolamine was the substrate. phosphatidylethanolamine 126-150 phospholipase A2 group IB Rattus norvegicus 35-51 18475477-2 1992 Melittin (2 mumol/l) was as potent as the calcium ionophore A23187 (10 mumol/l) for activation of 5-lipoxygenase, releasing arachidonate only from phosphatidyl-choline and phosphatidyl-ethanolamine of cellular membranes, as judged from the decreases in radioactivity by 15.4% and 30.5%, respectively. phosphatidylethanolamine 172-197 arachidonate 5-lipoxygenase Homo sapiens 98-112 1954254-1 1991 Phosphatidylethanolamine methyltransferase (PEMT) and phospholipid methyltransferase (PLMT), which are encoded by the CHO2 and OPI3 genes, respectively, catalyze the three-step methylation of phosphatidylethanolamine to phosphatidylcholine in Saccharomyces cerevisiae. phosphatidylethanolamine 192-216 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 118-122 1954254-1 1991 Phosphatidylethanolamine methyltransferase (PEMT) and phospholipid methyltransferase (PLMT), which are encoded by the CHO2 and OPI3 genes, respectively, catalyze the three-step methylation of phosphatidylethanolamine to phosphatidylcholine in Saccharomyces cerevisiae. phosphatidylethanolamine 192-216 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 127-131 1663666-4 1991 The two forms of PIP kinase showed similarity in Km for ATP and Mg2+ dependency, but some differences were observed in effects of Mn2+ and phosphatidylethanolamine on the activity. phosphatidylethanolamine 139-163 phosphatidylinositol-5-phosphate 4-kinase type 2 gamma Homo sapiens 17-27 1783615-12 1991 The isoforms nsLTP-A, -B, -C, and -D showed similar transfer activity not only for phosphatidylcholine and phosphatidylethanolamine but also for monogalactosyldiacylglycerol, although the homology among their amino acid sequences ranged from 70 to 30%. phosphatidylethanolamine 107-131 non-specific lipid-transfer protein C, cotyledon-specific isoform-like Ricinus communis 13-36 1816683-1 1991 Phospholipase A2 activity in the postnuclear supernatant of lymphocytes has been studied by measuring 14C arachidonate released from labelled phosphatidyl ethanolamine (PE) and phosphatidyl choline (PC) as exogenous substrates. phosphatidylethanolamine 142-167 phospholipase A2 group IB Rattus norvegicus 0-16 1816683-1 1991 Phospholipase A2 activity in the postnuclear supernatant of lymphocytes has been studied by measuring 14C arachidonate released from labelled phosphatidyl ethanolamine (PE) and phosphatidyl choline (PC) as exogenous substrates. phosphatidylethanolamine 169-171 phospholipase A2 group IB Rattus norvegicus 0-16 1653607-6 1991 Mixed vesicles of PIP2 with phosphatidylcholine or phosphatidylethanolamine also inhibit CapZ, but addition of Triton X-100 both prevents and reverses PIP2"s inhibition of CapZ. phosphatidylethanolamine 51-75 capping actin protein of muscle Z-line alpha subunit 2 Gallus gallus 89-93 1654115-4 1991 These results show that phospholipase A2 was activated in hypoxic myocytes and had substrate specificity towards PC and PE. phosphatidylethanolamine 120-122 phospholipase A2 group IB Homo sapiens 24-40 1656876-2 1991 Utilizing in vitro assay conditions where the membrane vesicles retained latency of glucose-6-phosphatase activity, the addition of phosphatidylethanolamine, cardiolipin, or monogalactosyldiglyceride resulted in severalfold increases in the rate of dolichol pyrophosphate N-acetylglucosamine synthesis. phosphatidylethanolamine 132-156 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 84-105 2022641-2 1991 PtdEtn is made in hepatocytes by two major pathways, (a) from CDP-ethanolamine on the endoplasmic reticulum and (b) by decarboxylation of phosphatidylserine in mitochondria. phosphatidylethanolamine 0-6 cut-like homeobox 1 Rattus norvegicus 62-65 1906891-6 1991 The rIL-1-stimulated PLA2 had an alkaline pH optimum, and phosphatidylethanolamine was preferred over phosphatidylcholine as substrate. phosphatidylethanolamine 58-82 phospholipase A2 group IIA Homo sapiens 21-25 2049075-0 1991 Phorbol ester and bryostatin differentially regulate the hydrolysis of phosphatidylethanolamine in Ha-ras- and raf-oncogene-transformed NIH 3T3 cells. phosphatidylethanolamine 71-95 Harvey rat sarcoma virus oncogene Mus musculus 99-105 2049075-0 1991 Phorbol ester and bryostatin differentially regulate the hydrolysis of phosphatidylethanolamine in Ha-ras- and raf-oncogene-transformed NIH 3T3 cells. phosphatidylethanolamine 71-95 zinc fingers and homeoboxes 2 Mus musculus 111-114 2045888-4 1991 PLA2 activities of each fraction were assayed by measuring release of arachidonic acid (AA) from exogenous 14C-AA-phosphatidylcholine (PC), -phosphatidylethanolamine (PE), and -phosphatidylinositol (PI). phosphatidylethanolamine 140-165 phospholipase A2 group IB Homo sapiens 0-4 2045888-4 1991 PLA2 activities of each fraction were assayed by measuring release of arachidonic acid (AA) from exogenous 14C-AA-phosphatidylcholine (PC), -phosphatidylethanolamine (PE), and -phosphatidylinositol (PI). phosphatidylethanolamine 167-169 phospholipase A2 group IB Homo sapiens 0-4 2029546-1 1991 The effect of the inclusion of phosphatidylethanolamine (PE), a phospholipid with unusual packing properties, on the substrate properties of protein-lipid complexes toward lecithin-cholesterol acyltransferase (LCAT) has been studied. phosphatidylethanolamine 31-55 lecithin-cholesterol acyltransferase Homo sapiens 172-208 2022747-3 1991 Two forms of PLA2 activity were present in the cytosolic fraction: a high molecular weight form, active against phosphatidylcholine (PC), and phosphatidylethanolamine (PE), which upon purification has a molecular mass of 110 kD; and smaller form (Mr approximately 14 kD), active against PE. phosphatidylethanolamine 142-166 phospholipase A2 group IB Rattus norvegicus 13-17 2022747-3 1991 Two forms of PLA2 activity were present in the cytosolic fraction: a high molecular weight form, active against phosphatidylcholine (PC), and phosphatidylethanolamine (PE), which upon purification has a molecular mass of 110 kD; and smaller form (Mr approximately 14 kD), active against PE. phosphatidylethanolamine 168-170 phospholipase A2 group IB Rattus norvegicus 13-17 2022747-3 1991 Two forms of PLA2 activity were present in the cytosolic fraction: a high molecular weight form, active against phosphatidylcholine (PC), and phosphatidylethanolamine (PE), which upon purification has a molecular mass of 110 kD; and smaller form (Mr approximately 14 kD), active against PE. phosphatidylethanolamine 287-289 phospholipase A2 group IB Rattus norvegicus 13-17 2029546-1 1991 The effect of the inclusion of phosphatidylethanolamine (PE), a phospholipid with unusual packing properties, on the substrate properties of protein-lipid complexes toward lecithin-cholesterol acyltransferase (LCAT) has been studied. phosphatidylethanolamine 31-55 lecithin-cholesterol acyltransferase Homo sapiens 210-214 2029546-1 1991 The effect of the inclusion of phosphatidylethanolamine (PE), a phospholipid with unusual packing properties, on the substrate properties of protein-lipid complexes toward lecithin-cholesterol acyltransferase (LCAT) has been studied. phosphatidylethanolamine 57-59 lecithin-cholesterol acyltransferase Homo sapiens 172-208 2029546-1 1991 The effect of the inclusion of phosphatidylethanolamine (PE), a phospholipid with unusual packing properties, on the substrate properties of protein-lipid complexes toward lecithin-cholesterol acyltransferase (LCAT) has been studied. phosphatidylethanolamine 57-59 lecithin-cholesterol acyltransferase Homo sapiens 210-214 1910288-3 1991 Tumor-derived cells exhibited significant PLA2 activity(ies) with arachidonoyl containing phosphatidylcholine and phosphatidylethanolamine as substrates in cell-free assays. phosphatidylethanolamine 114-138 phospholipase A2, group IB, pancreas Mus musculus 42-46 2002032-7 1991 When apolipoprotein E was injected beneath the monolayer of phosphatidylethanolamine prior to enzyme addition, a 3-fold activation of HL was observed at surface pressures equal to or below 15 mN/m. phosphatidylethanolamine 60-84 apolipoprotein E Homo sapiens 5-21 2002032-10 1991 At a high surface pressure of 25 mN/m all apolipoproteins tested (apolipoproteins A-I, A-II, C-I, C-II, C-III, and E) inhibited the penetration into and HL activity on phosphatidylethanolamine At 18.5 mN/m all apolipoproteins except apolipoprotein E inhibited the hydrolysis of triacylglycerol in the triacylglycerol:phosphatidylcholine mixed film. phosphatidylethanolamine 168-192 NLR family pyrin domain containing 3 Homo sapiens 42-96 1872466-8 1991 N. naja phospholipase A2 showed less preference for phosphatidylethanolamine than -choline as liposomes or yeast phospholipid as compared to human synovial fluid phospholipase A2 which clearly preferred phosphatidylethanolamine to -choline as a liposome or yeast phospholipid. phosphatidylethanolamine 52-76 phospholipase A2 group IB Homo sapiens 8-24 1872466-8 1991 N. naja phospholipase A2 showed less preference for phosphatidylethanolamine than -choline as liposomes or yeast phospholipid as compared to human synovial fluid phospholipase A2 which clearly preferred phosphatidylethanolamine to -choline as a liposome or yeast phospholipid. phosphatidylethanolamine 203-227 phospholipase A2 group IB Homo sapiens 8-24 2000640-6 1991 Phosphatidylethanolamine (PE) content was reduced (p less than 0.05), whereas lyso-PE (LPE), a product of PLA1 hydrolysis of PE, as well as phosphatidylserine (PS) contents were increased (p less than 0.01 for both LPE and PS) in the plasma membranes of NO2-exposed cells. phosphatidylethanolamine 83-85 POU class 2 homeobox 3 Homo sapiens 106-110 1705040-10 1991 Therefore, it is likely to result from hydrolysis of phosphatidylethanolamine by a specific phospholipase C. The response of the PMEs appears to be regulated by a cAMP-independent process, suggesting the existence of an alternative transduction pathway controlled by MSH. phosphatidylethanolamine 53-77 proopiomelanocortin Homo sapiens 267-270 1650774-0 1991 Identification of the upstream activation sequences responsible for the expression and regulation of the PEM1 and PEM2 genes encoding the enzymes of the phosphatidylethanolamine methylation pathway in Saccharomyces cerevisiae. phosphatidylethanolamine 153-177 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 105-109 2018133-3 1991 Differences in the distribution of phosphatidylcholine and phosphatidylethanolamine, as assessed by phospholipase A2 treatment and trinitrophenylation of aminophospholipids, were, at least partially, responsible for the asymmetrical fluidity of the hemileaflets. phosphatidylethanolamine 59-83 phospholipase A2 group IB Rattus norvegicus 100-116 1650774-0 1991 Identification of the upstream activation sequences responsible for the expression and regulation of the PEM1 and PEM2 genes encoding the enzymes of the phosphatidylethanolamine methylation pathway in Saccharomyces cerevisiae. phosphatidylethanolamine 153-177 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 114-118 1650774-1 1991 The yeast phosphatidylethanolamine methylation pathway is encoded by two structural genes, PEM1 and PEM2. phosphatidylethanolamine 10-34 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 91-95 1650774-1 1991 The yeast phosphatidylethanolamine methylation pathway is encoded by two structural genes, PEM1 and PEM2. phosphatidylethanolamine 10-34 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 100-104 2397247-13 1990 A mild cholesterol enrichment stimulated the phosphatidylethanolamine and triacylglycerol reactivities by 30-60% towards hepatic lipase, whereas increasing the triacylglycerol concentration in HDL was followed by a proportional increase in the amounts of triacylglycerol hydrolysed with no effect on phospholipid degradation. phosphatidylethanolamine 45-69 lipase C, hepatic type Homo sapiens 121-135 1991158-8 1991 These results suggest that an eicosanoid-independent degradation of phosphatidylethanolamine via phospholipase A2 at lower collagen levels may provide a source of the initial AA for conversion to TxA2 and the subsequent deacylation of phosphatidylinositol, phosphatidylcholine, and also phosphatidylserine. phosphatidylethanolamine 68-92 phospholipase A2 group IB Homo sapiens 97-113 1989575-0 1991 Synthesis of phosphatidylethanolamine and ethanolamine plasmalogen by the CDP-ethanolamine and decarboxylase pathways in rat heart, kidney and liver. phosphatidylethanolamine 13-37 cut-like homeobox 1 Rattus norvegicus 74-77 1989575-5 1991 The results obtained in this study indicate that: (1) the CDP-ethanolamine pathway is utilized for the synthesis of both PE and ethanolamine plasmalogen in all three tissues; (2) the decarboxylation pathway is utilized solely for the synthesis of PE; (3) serine plasmalogens are not formed by base-exchange reactions; (4) the relative utilization of the CDP-ethanolamine pathway for the synthesis of PE and ethanolamine plasmalogen varies among tissues. phosphatidylethanolamine 121-123 cut-like homeobox 1 Rattus norvegicus 58-61 1989575-5 1991 The results obtained in this study indicate that: (1) the CDP-ethanolamine pathway is utilized for the synthesis of both PE and ethanolamine plasmalogen in all three tissues; (2) the decarboxylation pathway is utilized solely for the synthesis of PE; (3) serine plasmalogens are not formed by base-exchange reactions; (4) the relative utilization of the CDP-ethanolamine pathway for the synthesis of PE and ethanolamine plasmalogen varies among tissues. phosphatidylethanolamine 247-249 cut-like homeobox 1 Rattus norvegicus 58-61 1989575-5 1991 The results obtained in this study indicate that: (1) the CDP-ethanolamine pathway is utilized for the synthesis of both PE and ethanolamine plasmalogen in all three tissues; (2) the decarboxylation pathway is utilized solely for the synthesis of PE; (3) serine plasmalogens are not formed by base-exchange reactions; (4) the relative utilization of the CDP-ethanolamine pathway for the synthesis of PE and ethanolamine plasmalogen varies among tissues. phosphatidylethanolamine 247-249 cut-like homeobox 1 Rattus norvegicus 58-61 1761153-9 1991 In the 24-hr variation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE), the lowest ratio of PC/PE was observed at 24:00-02:00 hr when SAH concentration is high, whereas the highest PC/PE ratio occurs at the same time as one of the SAM/SAH ratio maxima. phosphatidylethanolamine 55-79 procollagen C-endopeptidase enhancer Rattus norvegicus 81-83 1761153-9 1991 In the 24-hr variation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE), the lowest ratio of PC/PE was observed at 24:00-02:00 hr when SAH concentration is high, whereas the highest PC/PE ratio occurs at the same time as one of the SAM/SAH ratio maxima. phosphatidylethanolamine 55-79 procollagen C-endopeptidase enhancer Rattus norvegicus 106-111 1761153-9 1991 In the 24-hr variation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE), the lowest ratio of PC/PE was observed at 24:00-02:00 hr when SAH concentration is high, whereas the highest PC/PE ratio occurs at the same time as one of the SAM/SAH ratio maxima. phosphatidylethanolamine 55-79 procollagen C-endopeptidase enhancer Rattus norvegicus 195-200 1997787-4 1991 Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates. phosphatidylethanolamine 214-238 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 39-42 1997787-4 1991 Depending on the system, activation of PLD has been suggested to be either dependent on, or independent of, Ca2+ and protein kinase C. PLD primarily hydrolyses phosphatidylcholine (PC) but phosphatidylinositol and phosphatidylethanolamine have also been reported as substrates. phosphatidylethanolamine 214-238 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 135-138 2129343-4 1990 In contrast, palmitic acid (0-0.75 mM), phosphatidylethanolamine and sphingomyelin (0-200 micrograms/ml) stimulated GalT-2 activity by 20-36% as compared to control. phosphatidylethanolamine 40-64 beta-1,3-galactosyltransferase 4 Homo sapiens 116-122 2167132-3 1990 In this study, the effect of anionic phospholipids, diacylglycerol (DAG) and phosphatidylethanolamine (PE) on the activity of a partially purified, intracellular, arachidonoyl-hydrolyzing phospholipase A2 from the macrophage cell line, RAW 264.7 was studied. phosphatidylethanolamine 77-101 phospholipase A2 group IB Homo sapiens 188-204 2167132-3 1990 In this study, the effect of anionic phospholipids, diacylglycerol (DAG) and phosphatidylethanolamine (PE) on the activity of a partially purified, intracellular, arachidonoyl-hydrolyzing phospholipase A2 from the macrophage cell line, RAW 264.7 was studied. phosphatidylethanolamine 103-105 phospholipase A2 group IB Homo sapiens 188-204 2167132-8 1990 Co-dispersion of either DAG or PE with the substrate also induced a dose-dependent increase in phospholipase A2 activity, whereas sphingomyelin was inhibitory suggesting that the phospholipase A2 more readily hydrolyzed the ether-linked substrate when there was a decrease in the packing density of the bilayer. phosphatidylethanolamine 31-33 phospholipase A2 group IB Homo sapiens 95-111 2167132-8 1990 Co-dispersion of either DAG or PE with the substrate also induced a dose-dependent increase in phospholipase A2 activity, whereas sphingomyelin was inhibitory suggesting that the phospholipase A2 more readily hydrolyzed the ether-linked substrate when there was a decrease in the packing density of the bilayer. phosphatidylethanolamine 31-33 phospholipase A2 group IB Homo sapiens 179-195 2167132-9 1990 PIP2, together with either DAG or PE, synergistically stimulated phospholipase A2 activity by about 20-fold, and dramatically decreased the calcium concentration (from mM to nM) required for full activity of the enzyme. phosphatidylethanolamine 34-36 phospholipase A2 group IB Homo sapiens 65-81 1975258-11 1990 Phosphatidylethanolamine (PEA) decreased, while phosphatidylinositol (PI) increased in the plasma membranes isolated from the CCl4-treated group. phosphatidylethanolamine 0-24 C-C motif chemokine ligand 4 Homo sapiens 126-130 1975258-11 1990 Phosphatidylethanolamine (PEA) decreased, while phosphatidylinositol (PI) increased in the plasma membranes isolated from the CCl4-treated group. phosphatidylethanolamine 26-29 C-C motif chemokine ligand 4 Homo sapiens 126-130 2116166-4 1990 Although incubation of dimyristoylphosphatidylcholine (DMPC) with apolipoprotein A-I at the gel-liquid crystalline phase transition temperature results in the spontaneous formation of lipid-protein complexes, the presence of proportionately small amounts of PE prevents the formation of such complexes, suggesting that PE profoundly alters the phase properties of the phospholipid bilayers. phosphatidylethanolamine 258-260 apolipoprotein A1 Homo sapiens 66-84 2116166-4 1990 Although incubation of dimyristoylphosphatidylcholine (DMPC) with apolipoprotein A-I at the gel-liquid crystalline phase transition temperature results in the spontaneous formation of lipid-protein complexes, the presence of proportionately small amounts of PE prevents the formation of such complexes, suggesting that PE profoundly alters the phase properties of the phospholipid bilayers. phosphatidylethanolamine 319-321 apolipoprotein A1 Homo sapiens 66-84 2116166-5 1990 However, by using a detergent-mediated method for the formation of PE-rich model nascent HDL from phospholipids and apolipoprotein A-I, lipid-protein complexes containing as much as 75% DLPE could be formed, thus demonstrating that the presence of PE causes a kinetic, rather than a thermodynamic, barrier to spontaneous complex formation. phosphatidylethanolamine 67-69 apolipoprotein A1 Homo sapiens 116-134 2116167-5 1990 Phosphatidylethanolamine or stearylamine, having a positively charged group, reduced the catalytic efficiency of t-PA by raising its Km value (10-fold), whereas negatively charged phospholipids, phosphatidylserine and phosphatidylinositol, did not affect the efficiency. phosphatidylethanolamine 0-24 plasminogen activator, tissue type Homo sapiens 113-117 2398032-3 1990 Phosphorylated truncated pre IL 1 alpha selectively binds to acidic phospholipids including phosphatidic acid, phosphatidylserine, and phosphatidylinositol, but not to other phospholipids (phosphatidylcholine and phosphatidylethanolamine). phosphatidylethanolamine 213-237 interleukin 1 alpha Homo sapiens 29-39 2108162-3 1990 EGF-enhanced PLA2 activity as assayed by the ability of the soluble extracts of cells to cleave arachidonic acid from the sn-2 position of phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 163-187 epidermal growth factor like 1 Rattus norvegicus 0-3 2177172-4 1990 Likewise, PE was the donor of phosphoethanolamine for the synthesis of the ceramide-phosphoethanolamine in normal and Trembler mouse sciatic nerves and this synthesis was 3.5 times greater in the mutant than in controls. phosphatidylethanolamine 10-12 peripheral myelin protein 22 Mus musculus 118-126 2397247-0 1990 Kinetic evidence for phosphatidylethanolamine and triacylglycerol as preferential substrates for hepatic lipase in HDL subfractions: modulation by changes in the particle surface, or in the lipid core. phosphatidylethanolamine 21-45 lipase C, hepatic type Homo sapiens 97-111 2397247-7 1990 A strong correlation was observed between the hepatic lipase activity added and the maximal degradation rates for phosphatidylethanolamine measured in HDL2 and HDL3. phosphatidylethanolamine 114-138 lipase C, hepatic type Homo sapiens 46-60 2397247-7 1990 A strong correlation was observed between the hepatic lipase activity added and the maximal degradation rates for phosphatidylethanolamine measured in HDL2 and HDL3. phosphatidylethanolamine 114-138 junctophilin 3 Homo sapiens 151-155 2397247-7 1990 A strong correlation was observed between the hepatic lipase activity added and the maximal degradation rates for phosphatidylethanolamine measured in HDL2 and HDL3. phosphatidylethanolamine 114-138 HDL3 Homo sapiens 160-164 2397247-9 1990 The number of phosphatidylethanolamine molecules hydrolysed exceeded that of triacylglycerol by 30% in HDL2 and by 70% in HDL3. phosphatidylethanolamine 14-38 junctophilin 3 Homo sapiens 103-107 2397247-9 1990 The number of phosphatidylethanolamine molecules hydrolysed exceeded that of triacylglycerol by 30% in HDL2 and by 70% in HDL3. phosphatidylethanolamine 14-38 HDL3 Homo sapiens 122-126 2397247-10 1990 HDL2 were 2- and 4-times more reactive than HDL3 for the hydrolysis of phosphatidylethanolamine and triacylglycerol, respectively, taking the Vmax/Km ratio as an indicator of catalytic efficiency. phosphatidylethanolamine 71-95 junctophilin 3 Homo sapiens 0-4 2397247-10 1990 HDL2 were 2- and 4-times more reactive than HDL3 for the hydrolysis of phosphatidylethanolamine and triacylglycerol, respectively, taking the Vmax/Km ratio as an indicator of catalytic efficiency. phosphatidylethanolamine 71-95 HDL3 Homo sapiens 44-48 2108162-3 1990 EGF-enhanced PLA2 activity as assayed by the ability of the soluble extracts of cells to cleave arachidonic acid from the sn-2 position of phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 163-187 phospholipase A2 group IB Rattus norvegicus 13-17 2315927-11 1990 These data demonstrate that phenobarbital pretreatment is associated with a shift in the predominant phospholipid locus from phosphatidylserine to phosphatidylethanolamine for the early CCl4-induced fatty acid changes in rat liver microsomes. phosphatidylethanolamine 147-171 C-C motif chemokine ligand 4 Rattus norvegicus 186-190 2138016-4 1990 Only protein II, p68, lipocortin III and endonexin II bound to vesicles composed of phosphatidylethanolamine, and none bound to phosphatidylcholine. phosphatidylethanolamine 84-108 annexin A4 Homo sapiens 5-15 2138016-4 1990 Only protein II, p68, lipocortin III and endonexin II bound to vesicles composed of phosphatidylethanolamine, and none bound to phosphatidylcholine. phosphatidylethanolamine 84-108 annexin A3 Homo sapiens 22-36 2138016-4 1990 Only protein II, p68, lipocortin III and endonexin II bound to vesicles composed of phosphatidylethanolamine, and none bound to phosphatidylcholine. phosphatidylethanolamine 84-108 annexin A5 Homo sapiens 41-53 19398041-3 2009 It has been suggested that mitochondria may be one of the lipid sources for autophagosome formation and that possibly this organelle provides the phosphatidylethanolamine (PE) that covalently links to the members of the ubiquitin-like Atg8/microtubule-associated protein 1 light chain 3 (LC3) protein family. phosphatidylethanolamine 146-170 GABA type A receptor associated protein like 1 Homo sapiens 235-239 2158609-0 1990 Synergistic activation of CTP:phosphocholine cytidylyltransferase by phosphatidylethanolamine and oleic acid. phosphatidylethanolamine 69-93 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 26-65 2154211-2 1990 PAF ranging in concentration from 10(-6)-10(-9)M initiated the incorporation of 32P into phosphatidic acid (PA) and phosphatidylinositol (PI) with no change in phosphatidylethanolamine (PE) and phosphatidylcholine (PC) over baseline. phosphatidylethanolamine 186-188 PCNA clamp associated factor Homo sapiens 0-3 33821543-2 2021 ATP8a1, a protein involved in the translocation of phosphatidylserine and phosphatidylethanolamine across lipid bilayers, is the strongest binding partner of IFT27. phosphatidylethanolamine 74-98 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 Mus musculus 0-6 33821543-2 2021 ATP8a1, a protein involved in the translocation of phosphatidylserine and phosphatidylethanolamine across lipid bilayers, is the strongest binding partner of IFT27. phosphatidylethanolamine 74-98 intraflagellar transport 27 Mus musculus 158-163 33794068-0 2021 SMAC/Diablo controls proliferation of cancer cells by regulating phosphatidylethanolamine synthesis. phosphatidylethanolamine 65-89 diablo IAP-binding mitochondrial protein Homo sapiens 0-4 33794068-0 2021 SMAC/Diablo controls proliferation of cancer cells by regulating phosphatidylethanolamine synthesis. phosphatidylethanolamine 65-89 diablo IAP-binding mitochondrial protein Homo sapiens 5-11 33794068-4 2021 We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS). phosphatidylethanolamine 160-184 diablo IAP-binding mitochondrial protein Homo sapiens 15-19 33794068-4 2021 We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS). phosphatidylethanolamine 160-184 diablo IAP-binding mitochondrial protein Homo sapiens 20-26 33794068-4 2021 We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS). phosphatidylethanolamine 160-184 F-box and leucine rich repeat protein 15 Homo sapiens 99-102 33794068-4 2021 We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS). phosphatidylethanolamine 186-188 diablo IAP-binding mitochondrial protein Homo sapiens 15-19 33794068-4 2021 We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS). phosphatidylethanolamine 186-188 diablo IAP-binding mitochondrial protein Homo sapiens 20-26 33794068-4 2021 We showed that SMAC/Diablo directly interacts with mitochondrial phosphatidylserine decarboxylase (PSD) and inhibits its catalytic activity during synthesis of phosphatidylethanolamine (PE) from phosphatidylserine (PS). phosphatidylethanolamine 186-188 F-box and leucine rich repeat protein 15 Homo sapiens 99-102 33794068-6 2021 As a result, PSD activity and mitochondrial PE levels were increased in the mitochondria of SMAC/Diablo-deficient cancer cells, with the total amount of cellular phospholipids and phosphatidylcholine (PC) being lower as compared to SMAC-expressing cancer cells. phosphatidylethanolamine 44-46 diablo IAP-binding mitochondrial protein Homo sapiens 92-96 33794068-7 2021 Moreover, in the absence of SMAC/Diablo, PSD inhibited cancer cell proliferation by catalysing the overproduction of mitochondrial PE and depleting the cellular levels of PC, PE and PS. phosphatidylethanolamine 131-133 F-box and leucine rich repeat protein 15 Homo sapiens 41-44 33809964-7 2021 By contrast, the phosphatidylethanolamine N-methyl transferase (PEMT) pathway was restricted by low endogenous methionine and consequently low S-adenosylmethionine, which resulted in a concomitant decrease in phosphatidylcholine and accumulation of phosphatidylethanolamine. phosphatidylethanolamine 17-41 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 64-68 33235924-5 2020 Our MD results also indicate that Slp4-a needs Ca2+ to bind with weakly-charged POPE lipids (phosphatidylethanolamine). phosphatidylethanolamine 93-117 synaptotagmin like 4 Homo sapiens 34-38 2110108-1 1990 The role of NADPH--cytochrome P450 reductase and cytochrome P450 in NADPH- and ADP--Fe3(+)-dependent lipid peroxidation was investigated by using the purified enzymes and liposomes prepared from either total rat-liver phospholipids or a mixture of bovine phosphatidyl choline and phosphatidyl ethanolamine (PC/PE liposomes). phosphatidylethanolamine 280-305 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 19-34 2307391-2 1990 Employing [14C]-acetate as a substrate, PRL stimulates its incorporation into a) neutral lipids by 4-6 hours, b) phosphatidyl choline (PC) and phosphatidyl inositol-phosphatidyl serine (PI-PS) by 1-2 hours, and c) phosphatidyl ethanolamine (PE) by 2-4 hours. phosphatidylethanolamine 214-239 prolactin Mus musculus 40-43 2307391-2 1990 Employing [14C]-acetate as a substrate, PRL stimulates its incorporation into a) neutral lipids by 4-6 hours, b) phosphatidyl choline (PC) and phosphatidyl inositol-phosphatidyl serine (PI-PS) by 1-2 hours, and c) phosphatidyl ethanolamine (PE) by 2-4 hours. phosphatidylethanolamine 241-243 prolactin Mus musculus 40-43 33794068-7 2021 Moreover, in the absence of SMAC/Diablo, PSD inhibited cancer cell proliferation by catalysing the overproduction of mitochondrial PE and depleting the cellular levels of PC, PE and PS. phosphatidylethanolamine 175-177 F-box and leucine rich repeat protein 15 Homo sapiens 41-44 33794068-13 2021 Altogether, we demonstrated that phospholipid metabolism and PE synthesis regulated by the SMAC-PSD interaction are essential for cancer cell proliferation and may be potentially targeted for treating cancer. phosphatidylethanolamine 61-63 diablo IAP-binding mitochondrial protein Homo sapiens 91-95 33794068-13 2021 Altogether, we demonstrated that phospholipid metabolism and PE synthesis regulated by the SMAC-PSD interaction are essential for cancer cell proliferation and may be potentially targeted for treating cancer. phosphatidylethanolamine 61-63 F-box and leucine rich repeat protein 15 Homo sapiens 96-99 19398041-3 2009 It has been suggested that mitochondria may be one of the lipid sources for autophagosome formation and that possibly this organelle provides the phosphatidylethanolamine (PE) that covalently links to the members of the ubiquitin-like Atg8/microtubule-associated protein 1 light chain 3 (LC3) protein family. phosphatidylethanolamine 146-170 microtubule associated protein 1 light chain 3 alpha Homo sapiens 288-291 19398041-3 2009 It has been suggested that mitochondria may be one of the lipid sources for autophagosome formation and that possibly this organelle provides the phosphatidylethanolamine (PE) that covalently links to the members of the ubiquitin-like Atg8/microtubule-associated protein 1 light chain 3 (LC3) protein family. phosphatidylethanolamine 172-174 GABA type A receptor associated protein like 1 Homo sapiens 235-239 19398041-3 2009 It has been suggested that mitochondria may be one of the lipid sources for autophagosome formation and that possibly this organelle provides the phosphatidylethanolamine (PE) that covalently links to the members of the ubiquitin-like Atg8/microtubule-associated protein 1 light chain 3 (LC3) protein family. phosphatidylethanolamine 172-174 microtubule associated protein 1 light chain 3 alpha Homo sapiens 288-291 34332077-0 2021 Sphingomyelin synthase related protein is a mammalian phosphatidylethanolamine phospholipase C. Sphingomyelin synthase related protein (SMSr) has no SM synthase activity but has ceramide phosphorylethanolamine (CPE) synthase activity in vitro. phosphatidylethanolamine 54-78 sterile alpha motif domain containing 8 Homo sapiens 0-38 15104217-1 2004 OBJECTIVE: To investigate the potential effects of angiogenic process by secretory phospholipase A2 (sPLA2) inhibitor-HyPE (linking N-derivatized phosphatidyl-ethanolamine to hyaluronic acid) on human bone marrow endothelial cell line (HBME-1). phosphatidylethanolamine 146-171 phospholipase A2 group X Homo sapiens 73-99 15104217-1 2004 OBJECTIVE: To investigate the potential effects of angiogenic process by secretory phospholipase A2 (sPLA2) inhibitor-HyPE (linking N-derivatized phosphatidyl-ethanolamine to hyaluronic acid) on human bone marrow endothelial cell line (HBME-1). phosphatidylethanolamine 146-171 phospholipase A2 group X Homo sapiens 101-106 15104217-1 2004 OBJECTIVE: To investigate the potential effects of angiogenic process by secretory phospholipase A2 (sPLA2) inhibitor-HyPE (linking N-derivatized phosphatidyl-ethanolamine to hyaluronic acid) on human bone marrow endothelial cell line (HBME-1). phosphatidylethanolamine 146-171 FIC domain protein adenylyltransferase Homo sapiens 118-122 34597571-9 2022 Phosphatidylethanolamine (PE), phosphatidylserine (PS), and phosphatidylinositol (PI) were the major glycerophospholipids whose levels were altered in the lung, while phosphatidylglycerol (PG), phosphatidic acid (PA), and phosphatidylcholine (PC) levels changed dramatically in the serum. phosphatidylethanolamine 0-24 prolyl endopeptidase Rattus norvegicus 26-28 34708879-3 2022 Co-overexpression of Lem3 and Sfk1 (Lem3(M)-Sfk1(H) strain) through promoter engineering remodeled the membrane phospholipid distribution, leading to an increased accumulation of phosphatidylethanolamine in the inner leaflet of the plasma membrane. phosphatidylethanolamine 179-203 Lem3p Saccharomyces cerevisiae S288C 21-25 34708879-3 2022 Co-overexpression of Lem3 and Sfk1 (Lem3(M)-Sfk1(H) strain) through promoter engineering remodeled the membrane phospholipid distribution, leading to an increased accumulation of phosphatidylethanolamine in the inner leaflet of the plasma membrane. phosphatidylethanolamine 179-203 Sfk1p Saccharomyces cerevisiae S288C 30-34 34708879-3 2022 Co-overexpression of Lem3 and Sfk1 (Lem3(M)-Sfk1(H) strain) through promoter engineering remodeled the membrane phospholipid distribution, leading to an increased accumulation of phosphatidylethanolamine in the inner leaflet of the plasma membrane. phosphatidylethanolamine 179-203 Sfk1p Saccharomyces cerevisiae S288C 36-48 34880641-0 2021 PLIN2 Mediates Neuroinflammation and Oxidative/Nitrosative Stress via Downregulating Phosphatidylethanolamine in the Rostral Ventrolateral Medulla of Stressed Hypertensive Rats. phosphatidylethanolamine 85-109 perilipin 2 Rattus norvegicus 0-5 34880641-10 2021 PLIN2 knockdown upregulated the PE synthesis in microglia. phosphatidylethanolamine 32-34 perilipin 2 Rattus norvegicus 0-5 34419589-7 2021 Cellular phosphatidylcholine/phosphatidylethanolamine ratio was decreased only upon overexpression of the proteins, potentially contributing to altered ApoB100 assembly and secretion. phosphatidylethanolamine 29-53 apolipoprotein B Homo sapiens 152-159 34332077-0 2021 Sphingomyelin synthase related protein is a mammalian phosphatidylethanolamine phospholipase C. Sphingomyelin synthase related protein (SMSr) has no SM synthase activity but has ceramide phosphorylethanolamine (CPE) synthase activity in vitro. phosphatidylethanolamine 54-78 sterile alpha motif domain containing 8 Homo sapiens 96-134 34332077-0 2021 Sphingomyelin synthase related protein is a mammalian phosphatidylethanolamine phospholipase C. Sphingomyelin synthase related protein (SMSr) has no SM synthase activity but has ceramide phosphorylethanolamine (CPE) synthase activity in vitro. phosphatidylethanolamine 54-78 sterile alpha motif domain containing 8 Homo sapiens 136-140 34332077-3 2021 In this study, we utilized purified recombinant SMSr and adenovirus-mediated SMSr in vivo expression to show that SMSr has phosphatidylethanolamine phospholipases C (PE-PLC) activity, i.e., it can generate DAG through PE hydrolysis in the absence of ceramide. phosphatidylethanolamine 123-147 sterile alpha motif domain containing 8 Homo sapiens 114-118 34681834-5 2021 SELENOI is involved in two different pathways for the synthesis of phosphatidylethanolamine (PE) and plasmenyl PE, which are constituents of cellular membranes. phosphatidylethanolamine 67-91 selenoprotein I Homo sapiens 0-7 34681834-5 2021 SELENOI is involved in two different pathways for the synthesis of phosphatidylethanolamine (PE) and plasmenyl PE, which are constituents of cellular membranes. phosphatidylethanolamine 93-95 selenoprotein I Homo sapiens 0-7 34153339-7 2021 miR-424"s effect on glioblastoma apoptosis and cell-cycle arrest was verified using Annexin V- phosphatidylethanolamine (PE) and 7-minoactinomycin D (7-AAD) apoptosis assay and cell-cycle assay. phosphatidylethanolamine 121-123 microRNA 424 Homo sapiens 0-7 34528675-1 2021 ATP11C, a member of the P4-ATPase family, translocates phosphatidylserine and phosphatidylethanolamine at the plasma membrane. phosphatidylethanolamine 78-102 ATPase phospholipid transporting 11C Homo sapiens 0-6 34255834-8 2021 By performing the enzyme activity assay of candidate recombinant proteins, we found that ethanolamine-phosphate cytidylyltransferase (PCYT2), the key enzyme in de novo phosphatidylethanolamine biosynthesis, has CDP-Gro synthetic activity from glycerol-3-phosphate (Gro3P) and CTP. phosphatidylethanolamine 168-192 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 89-132 34255834-8 2021 By performing the enzyme activity assay of candidate recombinant proteins, we found that ethanolamine-phosphate cytidylyltransferase (PCYT2), the key enzyme in de novo phosphatidylethanolamine biosynthesis, has CDP-Gro synthetic activity from glycerol-3-phosphate (Gro3P) and CTP. phosphatidylethanolamine 168-192 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 134-139 34255834-8 2021 By performing the enzyme activity assay of candidate recombinant proteins, we found that ethanolamine-phosphate cytidylyltransferase (PCYT2), the key enzyme in de novo phosphatidylethanolamine biosynthesis, has CDP-Gro synthetic activity from glycerol-3-phosphate (Gro3P) and CTP. phosphatidylethanolamine 168-192 cut-like homeobox 1 Mus musculus 211-214 34255834-8 2021 By performing the enzyme activity assay of candidate recombinant proteins, we found that ethanolamine-phosphate cytidylyltransferase (PCYT2), the key enzyme in de novo phosphatidylethanolamine biosynthesis, has CDP-Gro synthetic activity from glycerol-3-phosphate (Gro3P) and CTP. phosphatidylethanolamine 168-192 chemokine (C-X-C motif) ligand 1 Mus musculus 215-218 34296398-1 2021 Human Atg3 (hAtg3) is an E2-like enzyme that catalyzes the conjugation of LC3 family proteins to phosphatidylethanolamine (PE) lipids in the autophagosomal membrane during autophagy. phosphatidylethanolamine 97-121 autophagy related 3 Homo sapiens 6-10 34296398-1 2021 Human Atg3 (hAtg3) is an E2-like enzyme that catalyzes the conjugation of LC3 family proteins to phosphatidylethanolamine (PE) lipids in the autophagosomal membrane during autophagy. phosphatidylethanolamine 97-121 autophagy related 3 Homo sapiens 12-17 34296398-1 2021 Human Atg3 (hAtg3) is an E2-like enzyme that catalyzes the conjugation of LC3 family proteins to phosphatidylethanolamine (PE) lipids in the autophagosomal membrane during autophagy. phosphatidylethanolamine 97-121 microtubule associated protein 1 light chain 3 alpha Homo sapiens 74-77 34296398-1 2021 Human Atg3 (hAtg3) is an E2-like enzyme that catalyzes the conjugation of LC3 family proteins to phosphatidylethanolamine (PE) lipids in the autophagosomal membrane during autophagy. phosphatidylethanolamine 123-125 autophagy related 3 Homo sapiens 6-10 34296398-1 2021 Human Atg3 (hAtg3) is an E2-like enzyme that catalyzes the conjugation of LC3 family proteins to phosphatidylethanolamine (PE) lipids in the autophagosomal membrane during autophagy. phosphatidylethanolamine 123-125 autophagy related 3 Homo sapiens 12-17 34296398-1 2021 Human Atg3 (hAtg3) is an E2-like enzyme that catalyzes the conjugation of LC3 family proteins to phosphatidylethanolamine (PE) lipids in the autophagosomal membrane during autophagy. phosphatidylethanolamine 123-125 microtubule associated protein 1 light chain 3 alpha Homo sapiens 74-77 34505572-2 2021 The ATG12-5-16L1 complex is responsible for conjugating members of the ubiquitin-like ATG8 protein family to phosphatidylethanolamine in the growing autophagosomal membrane, known as the phagophore. phosphatidylethanolamine 109-133 GABA type A receptor associated protein like 1 Homo sapiens 86-90 34259806-4 2021 This interaction is required for phosphatidylethanolamine (PE) production by the PS decarboxylase Psd2, whereby PS transported from the ER to the PM by Osh6/7 is endocytosed to the site of Psd2 in endosomes/Golgi/vacuoles. phosphatidylethanolamine 33-57 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 98-102 34259806-4 2021 This interaction is required for phosphatidylethanolamine (PE) production by the PS decarboxylase Psd2, whereby PS transported from the ER to the PM by Osh6/7 is endocytosed to the site of Psd2 in endosomes/Golgi/vacuoles. phosphatidylethanolamine 33-57 oxysterol-binding protein OSH6 Saccharomyces cerevisiae S288C 152-158 34259806-4 2021 This interaction is required for phosphatidylethanolamine (PE) production by the PS decarboxylase Psd2, whereby PS transported from the ER to the PM by Osh6/7 is endocytosed to the site of Psd2 in endosomes/Golgi/vacuoles. phosphatidylethanolamine 33-57 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 189-193 34153339-7 2021 miR-424"s effect on glioblastoma apoptosis and cell-cycle arrest was verified using Annexin V- phosphatidylethanolamine (PE) and 7-minoactinomycin D (7-AAD) apoptosis assay and cell-cycle assay. phosphatidylethanolamine 121-123 annexin A5 Homo sapiens 84-93 34251968-2 2021 During macroautophagy, Atg8-family proteins are specifically conjugated to phosphatidylethanolamine (PE) in forming, double-membrane autophagosomes. phosphatidylethanolamine 75-99 GABA type A receptor associated protein like 1 Homo sapiens 23-27 34251968-2 2021 During macroautophagy, Atg8-family proteins are specifically conjugated to phosphatidylethanolamine (PE) in forming, double-membrane autophagosomes. phosphatidylethanolamine 101-103 GABA type A receptor associated protein like 1 Homo sapiens 23-27 34193767-3 2021 Atg8 and Atg12 are ubiquitin-like proteins covalently conjugated with a phosphatidylethanolamine (PE) and Atg5, respectively, via enzymatic reactions. phosphatidylethanolamine 72-96 GABA type A receptor associated protein like 1 Homo sapiens 0-4 34193767-3 2021 Atg8 and Atg12 are ubiquitin-like proteins covalently conjugated with a phosphatidylethanolamine (PE) and Atg5, respectively, via enzymatic reactions. phosphatidylethanolamine 72-96 autophagy related 12 Homo sapiens 9-14 34193767-3 2021 Atg8 and Atg12 are ubiquitin-like proteins covalently conjugated with a phosphatidylethanolamine (PE) and Atg5, respectively, via enzymatic reactions. phosphatidylethanolamine 98-100 GABA type A receptor associated protein like 1 Homo sapiens 0-4 34193767-3 2021 Atg8 and Atg12 are ubiquitin-like proteins covalently conjugated with a phosphatidylethanolamine (PE) and Atg5, respectively, via enzymatic reactions. phosphatidylethanolamine 98-100 autophagy related 12 Homo sapiens 9-14 34268737-2 2021 CD300a is an inhibitory receptor which binds phosphatidylserine (PS) and phosphatidylethanolamine (PE), presented on the membranes of apoptotic cells. phosphatidylethanolamine 73-97 CD300A molecule Mus musculus 0-6 34268737-2 2021 CD300a is an inhibitory receptor which binds phosphatidylserine (PS) and phosphatidylethanolamine (PE), presented on the membranes of apoptotic cells. phosphatidylethanolamine 99-101 CD300A molecule Mus musculus 0-6 34268737-3 2021 CD300a binding to PS and PE, also known as the "eat me" signal, mediates immune tolerance to dying cells. phosphatidylethanolamine 25-27 CD300A molecule Mus musculus 0-6 34338142-2 2021 Atg3 functions as an E2-like enzyme promoting conjugation of Atg8-family proteins to phosphatidylethanolamine (PE), a lipid molecule embedded in the growing phagophore membrane during stress-induced autophagy. phosphatidylethanolamine 85-109 autophagy related 3 Homo sapiens 0-4 34259806-4 2021 This interaction is required for phosphatidylethanolamine (PE) production by the PS decarboxylase Psd2, whereby PS transported from the ER to the PM by Osh6/7 is endocytosed to the site of Psd2 in endosomes/Golgi/vacuoles. phosphatidylethanolamine 59-61 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 98-102 34259806-4 2021 This interaction is required for phosphatidylethanolamine (PE) production by the PS decarboxylase Psd2, whereby PS transported from the ER to the PM by Osh6/7 is endocytosed to the site of Psd2 in endosomes/Golgi/vacuoles. phosphatidylethanolamine 59-61 oxysterol-binding protein OSH6 Saccharomyces cerevisiae S288C 152-158 34572064-7 2021 We further investigated whether limited phosphatidylethanolamine (PE) availability in por1 was causative for reduced autophagy by overexpression of the PE-generating phosphatidylserine decarboxylase 1 (Psd1). phosphatidylethanolamine 40-64 porin POR1 Saccharomyces cerevisiae S288C 86-90 34490332-4 2021 The milk fat globule membrane contains large proportions of sphingomyelin (SM), phosphatidylcholine (PC), and phosphatidylethanolamine (PE), and some phosphatidylserine (PS), phosphatidylinositol (PI), and glycosphingolipids. phosphatidylethanolamine 110-134 milk fat globule EGF and factor V/VIII domain containing Homo sapiens 4-29 34490332-4 2021 The milk fat globule membrane contains large proportions of sphingomyelin (SM), phosphatidylcholine (PC), and phosphatidylethanolamine (PE), and some phosphatidylserine (PS), phosphatidylinositol (PI), and glycosphingolipids. phosphatidylethanolamine 136-138 milk fat globule EGF and factor V/VIII domain containing Homo sapiens 4-29 34338142-2 2021 Atg3 functions as an E2-like enzyme promoting conjugation of Atg8-family proteins to phosphatidylethanolamine (PE), a lipid molecule embedded in the growing phagophore membrane during stress-induced autophagy. phosphatidylethanolamine 85-109 GABA type A receptor associated protein like 1 Homo sapiens 61-65 34338142-2 2021 Atg3 functions as an E2-like enzyme promoting conjugation of Atg8-family proteins to phosphatidylethanolamine (PE), a lipid molecule embedded in the growing phagophore membrane during stress-induced autophagy. phosphatidylethanolamine 111-113 autophagy related 3 Homo sapiens 0-4 34338142-2 2021 Atg3 functions as an E2-like enzyme promoting conjugation of Atg8-family proteins to phosphatidylethanolamine (PE), a lipid molecule embedded in the growing phagophore membrane during stress-induced autophagy. phosphatidylethanolamine 111-113 GABA type A receptor associated protein like 1 Homo sapiens 61-65 34696671-0 2021 Constitutive oxidants from hepatocytes of male iPLA2beta-null mice increases the externalization of phosphatidylethanolamine on plasma membrane. phosphatidylethanolamine 100-124 phospholipase A2, group VI Mus musculus 47-56 34088555-1 2021 During autophagy, proteins of the ATG8 family are conjugated to phosphatidylethanolamine (PE) in double-membrane structures called phagophores. phosphatidylethanolamine 64-88 GABA type A receptor associated protein like 1 Homo sapiens 34-38 34088555-1 2021 During autophagy, proteins of the ATG8 family are conjugated to phosphatidylethanolamine (PE) in double-membrane structures called phagophores. phosphatidylethanolamine 90-92 GABA type A receptor associated protein like 1 Homo sapiens 34-38 34696671-1 2021 We have found that group VIA calcium-independent phospholipase A2 (iPLA2beta) has specificity for hydrolysis of phosphatidylethanolamine (PE) in mouse livers. phosphatidylethanolamine 112-136 phospholipase A2, group VI Mus musculus 67-76 34696671-1 2021 We have found that group VIA calcium-independent phospholipase A2 (iPLA2beta) has specificity for hydrolysis of phosphatidylethanolamine (PE) in mouse livers. phosphatidylethanolamine 138-140 phospholipase A2, group VI Mus musculus 67-76 34696671-3 2021 Here we demonstrated that hepatocytes of iPLA2beta-null (KO) mice showed an increase in PE containing palmitate and oleate. phosphatidylethanolamine 88-90 phospholipase A2, group VI Mus musculus 41-50 34067848-3 2021 By changing lipid compositions when assaying a type II NADH:quinone oxidoreductase, we demonstrate that phosphatidylethanolamine has an essential role in substrate binding and catalysis. phosphatidylethanolamine 104-128 crystallin zeta Homo sapiens 60-82 34277122-6 2021 Significant changes were found in the lipidome of CPT1C-depleted cells, including major alterations in fatty acid, diacylglycerol, triacylglycerol, oxidative lipids, cardiolipin, phosphatidylglycerol, phosphatidylcholine/phosphatidylethanolamine ratio and sphingomyelin. phosphatidylethanolamine 221-245 carnitine palmitoyltransferase 1C Homo sapiens 50-55 34067535-1 2021 We recently discovered an anti-ferroptotic mechanism inherent to M1 macrophages whereby high levels of NO suppressed ferroptosis via inhibition of hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) production by 15-lipoxygenase (15LOX) complexed with PE-binding protein 1 (PEBP1). phosphatidylethanolamine 176-201 arachidonate 15-lipoxygenase Homo sapiens 227-242 34067535-1 2021 We recently discovered an anti-ferroptotic mechanism inherent to M1 macrophages whereby high levels of NO suppressed ferroptosis via inhibition of hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) production by 15-lipoxygenase (15LOX) complexed with PE-binding protein 1 (PEBP1). phosphatidylethanolamine 176-201 arachidonate 15-lipoxygenase Homo sapiens 244-249 34067535-1 2021 We recently discovered an anti-ferroptotic mechanism inherent to M1 macrophages whereby high levels of NO suppressed ferroptosis via inhibition of hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) production by 15-lipoxygenase (15LOX) complexed with PE-binding protein 1 (PEBP1). phosphatidylethanolamine 176-201 phosphatidylethanolamine binding protein 1 Homo sapiens 266-286 34067535-1 2021 We recently discovered an anti-ferroptotic mechanism inherent to M1 macrophages whereby high levels of NO suppressed ferroptosis via inhibition of hydroperoxy-eicosatetraenoyl-phosphatidylethanolamine (HpETE-PE) production by 15-lipoxygenase (15LOX) complexed with PE-binding protein 1 (PEBP1). phosphatidylethanolamine 176-201 phosphatidylethanolamine binding protein 1 Homo sapiens 288-293 34225916-2 2021 Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) plays a crucial role during autophagosome formation, as cleavage of its immature form and subsequent conjugation to phosphatidylethanolamine facilitates autophagosomal membrane biogenesis. phosphatidylethanolamine 200-224 microtubule associated protein 1 light chain 3 beta Homo sapiens 0-52 35584957-4 2022 Red cordyceps egg yolk powder (RCEYP) was selected as the raw material to obtain high content of PC and PE by ethanol extraction and low temperature cryoprecipitation in n-hexane-acetone system (HAS), in which the process conditions of PC and PE extraction by HAS process were optimized. phosphatidylethanolamine 104-106 pyruvate carboxylase Homo sapiens 236-238 35584957-4 2022 Red cordyceps egg yolk powder (RCEYP) was selected as the raw material to obtain high content of PC and PE by ethanol extraction and low temperature cryoprecipitation in n-hexane-acetone system (HAS), in which the process conditions of PC and PE extraction by HAS process were optimized. phosphatidylethanolamine 243-245 pyruvate carboxylase Homo sapiens 97-99 34234346-4 2021 Using in vivo CRISPR-Cas9 screening and functional validation in mice, we identify ETNK1, PCYT2, and SELENOI-enzymes in the CDP-ethanolamine pathway for de novo synthesis of phosphatidylethanolamine (PE)-as selective post-transcriptional regulators of TFH cell differentiation that act by promoting the surface expression and functional effects of CXCR5. phosphatidylethanolamine 174-198 ethanolamine kinase 1 Mus musculus 83-88 34234346-4 2021 Using in vivo CRISPR-Cas9 screening and functional validation in mice, we identify ETNK1, PCYT2, and SELENOI-enzymes in the CDP-ethanolamine pathway for de novo synthesis of phosphatidylethanolamine (PE)-as selective post-transcriptional regulators of TFH cell differentiation that act by promoting the surface expression and functional effects of CXCR5. phosphatidylethanolamine 174-198 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 90-95 34234346-4 2021 Using in vivo CRISPR-Cas9 screening and functional validation in mice, we identify ETNK1, PCYT2, and SELENOI-enzymes in the CDP-ethanolamine pathway for de novo synthesis of phosphatidylethanolamine (PE)-as selective post-transcriptional regulators of TFH cell differentiation that act by promoting the surface expression and functional effects of CXCR5. phosphatidylethanolamine 174-198 chemokine (C-X-C motif) receptor 5 Mus musculus 348-353 34234346-4 2021 Using in vivo CRISPR-Cas9 screening and functional validation in mice, we identify ETNK1, PCYT2, and SELENOI-enzymes in the CDP-ethanolamine pathway for de novo synthesis of phosphatidylethanolamine (PE)-as selective post-transcriptional regulators of TFH cell differentiation that act by promoting the surface expression and functional effects of CXCR5. phosphatidylethanolamine 200-202 ethanolamine kinase 1 Mus musculus 83-88 34234346-4 2021 Using in vivo CRISPR-Cas9 screening and functional validation in mice, we identify ETNK1, PCYT2, and SELENOI-enzymes in the CDP-ethanolamine pathway for de novo synthesis of phosphatidylethanolamine (PE)-as selective post-transcriptional regulators of TFH cell differentiation that act by promoting the surface expression and functional effects of CXCR5. phosphatidylethanolamine 200-202 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 90-95 34234346-4 2021 Using in vivo CRISPR-Cas9 screening and functional validation in mice, we identify ETNK1, PCYT2, and SELENOI-enzymes in the CDP-ethanolamine pathway for de novo synthesis of phosphatidylethanolamine (PE)-as selective post-transcriptional regulators of TFH cell differentiation that act by promoting the surface expression and functional effects of CXCR5. phosphatidylethanolamine 200-202 chemokine (C-X-C motif) receptor 5 Mus musculus 348-353 34234346-5 2021 TFH cells exhibit unique lipid metabolic programs and PE is distributed to the outer layer of the plasma membrane, where it colocalizes with CXCR5. phosphatidylethanolamine 54-56 chemokine (C-X-C motif) receptor 5 Mus musculus 141-146 34234346-6 2021 De novo synthesis of PE through the CDP-ethanolamine pathway co-ordinates these events to prevent the internalization and degradation of CXCR5. phosphatidylethanolamine 21-23 chemokine (C-X-C motif) receptor 5 Mus musculus 137-142 34382031-15 2021 Polymorphisms in the LIPC gene were associated with phosphatidylethanolamine metabolites, which are glycerophospholipids, and polymorphisms in the ASPM gene with branched-chain amino acids. phosphatidylethanolamine 52-76 lipase C, hepatic type Homo sapiens 21-25 35348973-8 2022 Interestingly, the comprehensive analysis of transcriptomics and metabolomics indicated that Asiatic acid inhibited the gene expression of Gpat3 and thereby affected the biosynthesis of the metabolites (1-acyl-Sn-glycerol-3-phosphocholine, phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine), regulating the glycerophospholipid metabolism pathway and ultimately ameliorating hepatocyte damage. phosphatidylethanolamine 261-285 glycerol-3-phosphate acyltransferase 3 Rattus norvegicus 139-144 34225916-2 2021 Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3) plays a crucial role during autophagosome formation, as cleavage of its immature form and subsequent conjugation to phosphatidylethanolamine facilitates autophagosomal membrane biogenesis. phosphatidylethanolamine 200-224 microtubule associated protein 1 light chain 3 alpha Homo sapiens 79-82 35474485-7 2022 Furthermore, pre-treatment of H121 and L13 pectins could improve the serum glycerophospholipids such as phosphatidylcholine (PC) and phosphatidylethanolamine (PE). phosphatidylethanolamine 133-157 skull morphology 20 Mus musculus 39-42 35617134-4 2022 Mechanistically, deletion of Vmp1 leads to decreased hepatic phosphatidylcholine (PC) and phosphatidylethanolamine (PE) levels as well as altered PC and PE acyl chain compositions resulting in the accumulation of neutral lipid structures in the ER phospholipid bilayer and decreased pre-VLDL assembly. phosphatidylethanolamine 90-114 vacuole membrane protein 1 Mus musculus 29-33 35617134-4 2022 Mechanistically, deletion of Vmp1 leads to decreased hepatic phosphatidylcholine (PC) and phosphatidylethanolamine (PE) levels as well as altered PC and PE acyl chain compositions resulting in the accumulation of neutral lipid structures in the ER phospholipid bilayer and decreased pre-VLDL assembly. phosphatidylethanolamine 116-118 vacuole membrane protein 1 Mus musculus 29-33 35474485-7 2022 Furthermore, pre-treatment of H121 and L13 pectins could improve the serum glycerophospholipids such as phosphatidylcholine (PC) and phosphatidylethanolamine (PE). phosphatidylethanolamine 159-161 skull morphology 20 Mus musculus 39-42 35478270-8 2022 The microvillus defects in larvae with reduced Cyp311a1 expression are restored by supplying PE, a major phospholipid of plasma membranes, to the food. phosphatidylethanolamine 93-95 Cyp311a1 Drosophila melanogaster 47-55 35100334-0 2022 pdx1 Knockout Leads to a Diabetic Nephropathy-Like Phenotype in Zebrafish and Identifies Phosphatidylethanolamine as Metabolite Promoting Early Diabetic Kidney Damage. phosphatidylethanolamine 89-113 pancreatic and duodenal homeobox 1 Danio rerio 0-4 35478270-10 2022 Together, these results suggest that the anterior midgut is an import hub in lipid distribution and that the midgut-specific CYP311A1 contributes to this function by participating in shaping microvilli in a PE-dependent manner. phosphatidylethanolamine 207-209 Cyp311a1 Drosophila melanogaster 125-133 35448353-5 2022 From the species analysis by mass spectrometry, phosphatidylethanolamine showed changed species content after TAZ knockout. phosphatidylethanolamine 48-72 tafazzin, phospholipid-lysophospholipid transacylase Homo sapiens 110-113 35435792-1 2022 ABBREVIATIONS: CP: coat protein; MAPK: mitogen-activated protein kinase; PEBP: phosphatidylethanolamine binding protein; TYLCV: tomato yellow leaf curl virus. phosphatidylethanolamine 79-103 phosphatidylethanolamine binding protein 1 Homo sapiens 73-77 35618088-9 2022 In our case, a mutant in the C-terminal amino acid, LC3C G126C, together with the use of a maleimide-derivatized phosphatidyl ethanolamine, ensured LC3C lipidation, up to 100% under certain conditions. phosphatidylethanolamine 113-138 microtubule associated protein 1 light chain 3 gamma Homo sapiens 148-152 35452693-8 2022 Mechanistically, loss of Vmp1 led to decreased hepatic levels of phosphatidylcholine and phosphatidylethanolamine as well as the changes of phospholipid composition. phosphatidylethanolamine 89-113 vacuole membrane protein 1 Mus musculus 25-29 35278131-10 2022 Haploinsufficiency of ATP11A, the phospholipid flippase that specially transports phosphatidylserine (PS) and phosphatidylethanolamine (PE), could leave cells with PS/PE at the extracellular side vulnerable to phagocytic degradation. phosphatidylethanolamine 110-134 ATPase phospholipid transporting 11A Homo sapiens 22-28 35278131-10 2022 Haploinsufficiency of ATP11A, the phospholipid flippase that specially transports phosphatidylserine (PS) and phosphatidylethanolamine (PE), could leave cells with PS/PE at the extracellular side vulnerable to phagocytic degradation. phosphatidylethanolamine 136-138 ATPase phospholipid transporting 11A Homo sapiens 22-28 35278131-10 2022 Haploinsufficiency of ATP11A, the phospholipid flippase that specially transports phosphatidylserine (PS) and phosphatidylethanolamine (PE), could leave cells with PS/PE at the extracellular side vulnerable to phagocytic degradation. phosphatidylethanolamine 167-169 ATPase phospholipid transporting 11A Homo sapiens 22-28 35503176-3 2022 SMS1 and SMS2 are two phosphatidylcholine (PC)-PLCs and SMSr is a phosphatidylethanolamine (PE)-PLC. phosphatidylethanolamine 92-94 sterile alpha motif domain containing 8 Homo sapiens 56-60 35185169-7 2022 Combined with PCA and RDA, the results showed that the changes of fatty acid content were negatively correlated with the changes of peroxide value, while the changes of PC and PE were positively correlated, and the contents of fatty acids, PE, PI and PC were negatively correlated with the changes of POV, of which PE and POV were the most correlated. phosphatidylethanolamine 240-242 pyruvate carboxylase Homo sapiens 169-171 35159276-5 2022 We have analysed the effects of this small molecule on the autophagic process in mouse neuronal cells and found that NSC48478 induces the conversion of microtubule-associated protein 1A/1B-light chain 3 (LC3-I) into the LC3-phosphatidylethanolamine conjugate (LC3-II). phosphatidylethanolamine 224-248 microtubule-associated protein 1 A Mus musculus 152-188 35159276-5 2022 We have analysed the effects of this small molecule on the autophagic process in mouse neuronal cells and found that NSC48478 induces the conversion of microtubule-associated protein 1A/1B-light chain 3 (LC3-I) into the LC3-phosphatidylethanolamine conjugate (LC3-II). phosphatidylethanolamine 224-248 microtubule-associated protein 1 light chain 3 alpha Mus musculus 204-207 35058529-2 2022 This study investigates the age-dependent liver defects during NASH development in mice with heterozygous deletion of Pcyt2 (Pcyt2+/-), the rate limiting enzyme in phosphatidylethanolamine (PE) synthesis. phosphatidylethanolamine 164-188 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 118-123 35058529-2 2022 This study investigates the age-dependent liver defects during NASH development in mice with heterozygous deletion of Pcyt2 (Pcyt2+/-), the rate limiting enzyme in phosphatidylethanolamine (PE) synthesis. phosphatidylethanolamine 190-192 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 118-123 35058529-2 2022 This study investigates the age-dependent liver defects during NASH development in mice with heterozygous deletion of Pcyt2 (Pcyt2+/-), the rate limiting enzyme in phosphatidylethanolamine (PE) synthesis. phosphatidylethanolamine 190-192 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 125-130 35071223-3 2021 In yeast cells, the methyltransferase, Cho2, converts PE to phosphatidylmonomethylethanolamine (PMME), which is further modified to PC by another methyltransferase, Opi3. phosphatidylethanolamine 54-56 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 39-43 35071223-3 2021 In yeast cells, the methyltransferase, Cho2, converts PE to phosphatidylmonomethylethanolamine (PMME), which is further modified to PC by another methyltransferase, Opi3. phosphatidylethanolamine 54-56 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 165-169 35503176-3 2022 SMS1 and SMS2 are two phosphatidylcholine (PC)-PLCs and SMSr is a phosphatidylethanolamine (PE)-PLC. phosphatidylethanolamine 66-90 sterile alpha motif domain containing 8 Homo sapiens 56-60 35015055-0 2022 Vps13-like proteins provide phosphatidylethanolamine for GPI anchor synthesis in the ER. phosphatidylethanolamine 28-52 epiregulin Homo sapiens 85-87 35131264-0 2022 LPGAT1 controls the stearate/palmitate ratio of phosphatidylethanolamine and phosphatidylcholine in sn-1 specific remodeling. phosphatidylethanolamine 48-72 lysophosphatidylglycerol acyltransferase 1 Mus musculus 0-6 35131264-3 2022 Here we demonstrate that lysophosphatidylglycerol acyltransferase 1 (LPGAT1) is an sn-1 specific acyltransferase that controls the stearate/palmitate ratio of phosphatidylethanolamine (PE) and phosphatidylcholine (PC). phosphatidylethanolamine 159-183 lysophosphatidylglycerol acyltransferase 1 Mus musculus 25-67 35131264-3 2022 Here we demonstrate that lysophosphatidylglycerol acyltransferase 1 (LPGAT1) is an sn-1 specific acyltransferase that controls the stearate/palmitate ratio of phosphatidylethanolamine (PE) and phosphatidylcholine (PC). phosphatidylethanolamine 159-183 lysophosphatidylglycerol acyltransferase 1 Homo sapiens 69-75 35131264-3 2022 Here we demonstrate that lysophosphatidylglycerol acyltransferase 1 (LPGAT1) is an sn-1 specific acyltransferase that controls the stearate/palmitate ratio of phosphatidylethanolamine (PE) and phosphatidylcholine (PC). phosphatidylethanolamine 185-187 lysophosphatidylglycerol acyltransferase 1 Mus musculus 25-67 35131264-3 2022 Here we demonstrate that lysophosphatidylglycerol acyltransferase 1 (LPGAT1) is an sn-1 specific acyltransferase that controls the stearate/palmitate ratio of phosphatidylethanolamine (PE) and phosphatidylcholine (PC). phosphatidylethanolamine 185-187 lysophosphatidylglycerol acyltransferase 1 Homo sapiens 69-75 35503176-4 2022 SMS family members not only influence SM levels but also influence the levels of diacylglycerol (DAG), PC, PE, and glycosphingolipids, thus influencing cell functions. phosphatidylethanolamine 107-109 spermine synthase Homo sapiens 0-3 2806192-1 1989 Phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) were co-isolated with the low molecular weight rat surfactant-associated protein C (SP-C) of Mr approximately equal to 6,000. phosphatidylethanolamine 0-24 surfactant protein C Rattus norvegicus 111-142 2684666-1 1989 PEM1 and PEM2 are structural genes for the yeast phosphatidylethanolamine methylation pathway which mediates the three-step methylation of phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 49-73 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 0-4 2684666-1 1989 PEM1 and PEM2 are structural genes for the yeast phosphatidylethanolamine methylation pathway which mediates the three-step methylation of phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 49-73 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 9-13 2684666-1 1989 PEM1 and PEM2 are structural genes for the yeast phosphatidylethanolamine methylation pathway which mediates the three-step methylation of phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 139-163 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 0-4 2684666-1 1989 PEM1 and PEM2 are structural genes for the yeast phosphatidylethanolamine methylation pathway which mediates the three-step methylation of phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 139-163 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 9-13 2811608-1 1989 Previous studies on alpha-lactalbumin induced fusion of phosphatidylserine/phosphatidylethanolamine vesicles are extended to vesicles composed of various combinations of phosphatidylserine, phosphatidylethanolamine, phosphatidylcholine and cardiolipin. phosphatidylethanolamine 75-99 lactalbumin alpha Homo sapiens 20-37 2806192-5 1989 SP-C augmented the cellular uptake of the PC liposomes only when the SP-C preparation had a protein to phospholipid ratio greater than 1 and a PG to PE ratio greater than 2. phosphatidylethanolamine 149-151 surfactant protein C Rattus norvegicus 0-4 2806192-6 1989 The results with the isolated SP-C could be reproduced using mixtures of PG and PE which reflected the phospholipid composition of the SP-C in the absence of SP-C protein. phosphatidylethanolamine 80-82 surfactant protein C Rattus norvegicus 30-34 2806192-6 1989 The results with the isolated SP-C could be reproduced using mixtures of PG and PE which reflected the phospholipid composition of the SP-C in the absence of SP-C protein. phosphatidylethanolamine 80-82 surfactant protein C Rattus norvegicus 135-139 2806192-6 1989 The results with the isolated SP-C could be reproduced using mixtures of PG and PE which reflected the phospholipid composition of the SP-C in the absence of SP-C protein. phosphatidylethanolamine 80-82 surfactant protein C Rattus norvegicus 135-139 2617942-4 1989 The diet of coast Chuchkchee land inhabitants, involving the higher level of unsaturated fatty acids n-3, resulted in the higher ratio between HDL cholesterol and apoA-I, in the higher part of unsaturated fatty acids n-3 in blood plasma lipids (phospholipids and cholesterol esters) and erythrocytes; it led to a relative increase of sphingomyelin and phosphatidyl-ethanolamine and to a decrease of phosphatidylcholine in HDL subfractions. phosphatidylethanolamine 352-377 apolipoprotein A1 Homo sapiens 163-169 2806192-1 1989 Phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) were co-isolated with the low molecular weight rat surfactant-associated protein C (SP-C) of Mr approximately equal to 6,000. phosphatidylethanolamine 0-24 surfactant protein C Rattus norvegicus 144-148 2758043-1 1989 The alpha-lactalbumin segment which penetrates into phosphatidylserine/phosphatidylethanolamine vesicle bilayer under acidic condition was photoactively labeled with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine [( 125I]TID) which had been partitioned into the hydrophobic interior of the bilayer. phosphatidylethanolamine 71-95 lactalbumin alpha Homo sapiens 4-21 2764877-5 1989 Plasma from uninephrectomized rats also stimulates [3H]arachidonic acid release from phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) via activation of phospholipase A2. phosphatidylethanolamine 144-150 phospholipase A2 group IB Rattus norvegicus 170-186 2742867-0 1989 18O isotope exchange experiments on phospholipase A2 determined by 13C-NMR: monomeric phosphatidylcholine and micellar phosphatidylethanolamine substrates. phosphatidylethanolamine 119-143 phospholipase A2 group IB Homo sapiens 36-52 2766434-3 1989 The crosslinked phosphatidylethanolamine species were separated from minor products and the reactants by extraction and two-dimensional thin-layer chromatography on silica gel G, gel filtration on lipophilic Sephadex, or C18-reversed phase high-performance liquid chromatography (HPLC). phosphatidylethanolamine 16-40 Bardet-Biedl syndrome 9 Homo sapiens 221-224 2487757-4 1989 Hydrolysis of PC and PE with phospholipase A2 (EC 3.1.1.4) released about 50% of the total radioactivity as lipid moieties corresponding to fatty acids. phosphatidylethanolamine 21-23 phospholipase A2 group IB Rattus norvegicus 29-45 2499328-0 1989 Biosynthesis of phosphatidylethanolamine via the CDP-ethanolamine route is an important pathway in isolated rat hepatocytes. phosphatidylethanolamine 16-40 cut-like homeobox 1 Rattus norvegicus 49-52 2540712-1 1989 Fusion of phosphatidylserine/phosphatidylethanolamine (1/1) vesicles induced by cytochrome c is studied at a wide range of pH values. phosphatidylethanolamine 29-53 cytochrome c, somatic Homo sapiens 80-92 2507337-2 1989 Prolactin (20 ng/ml) caused (a) a 20-60% loss of radiolabeled phosphatidylethanolamine within 0.5 to 2 min, (b) a loss of [3H]ethanolamine-labeled phosphatidylethanolamine from crude membranes, (c) a rapid accumulation of [3H]phosphoethanolamine and [3H]ethanolamine, and (d) a transient increase (15 s to 2 min) in prostaglandin F2 alpha and E2. phosphatidylethanolamine 62-86 prolactin Rattus norvegicus 0-9 2507337-2 1989 Prolactin (20 ng/ml) caused (a) a 20-60% loss of radiolabeled phosphatidylethanolamine within 0.5 to 2 min, (b) a loss of [3H]ethanolamine-labeled phosphatidylethanolamine from crude membranes, (c) a rapid accumulation of [3H]phosphoethanolamine and [3H]ethanolamine, and (d) a transient increase (15 s to 2 min) in prostaglandin F2 alpha and E2. phosphatidylethanolamine 147-171 prolactin Rattus norvegicus 0-9 2758074-1 1989 The specificity of snake venom phospholipase A2(PLA2) towards a number of phospholipid (PL) substrates, e. g., phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) organized in Triton X-100 mixed micelles, liposomes and proteoliposomes was studied. phosphatidylethanolamine 164-188 phospholipase A2 group IB Homo sapiens 31-47 2539188-1 1989 Neutral phospholipase A2 activity, which hydrolyzed phosphatidylcholine and phosphatidylethanolamine with the same efficiency, was identified in the nuclear matrix prepared from purified nuclei of rat ascites hepatoma cells (AH 7974). phosphatidylethanolamine 76-100 phospholipase A2 group IB Rattus norvegicus 8-24 2758074-1 1989 The specificity of snake venom phospholipase A2(PLA2) towards a number of phospholipid (PL) substrates, e. g., phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) organized in Triton X-100 mixed micelles, liposomes and proteoliposomes was studied. phosphatidylethanolamine 164-188 phospholipase A2 group IIA Homo sapiens 48-52 2758074-1 1989 The specificity of snake venom phospholipase A2(PLA2) towards a number of phospholipid (PL) substrates, e. g., phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) organized in Triton X-100 mixed micelles, liposomes and proteoliposomes was studied. phosphatidylethanolamine 190-192 phospholipase A2 group IB Homo sapiens 31-47 2758074-1 1989 The specificity of snake venom phospholipase A2(PLA2) towards a number of phospholipid (PL) substrates, e. g., phosphatidylcholine (PC), phosphatidylglycerol (PG), phosphatidylethanolamine (PE) and phosphatidylinositol (PI) organized in Triton X-100 mixed micelles, liposomes and proteoliposomes was studied. phosphatidylethanolamine 190-192 phospholipase A2 group IIA Homo sapiens 48-52 2704040-2 1989 By measuring surface pressure at constant surface area, p68 was found to interact in a Ca2+ -dependent manner specifically with phosphatidylethanolamine, less so with phosphatidylserine and not at all with phosphatidylcholine. phosphatidylethanolamine 128-152 KH RNA binding domain containing, signal transduction associated 1 Homo sapiens 56-59 2854123-6 1988 The CHO1-disrupted mutant, when grown on choline, accumulated phosphatidylethanolamine to a significant level even after extensive dilution of the initial culture. phosphatidylethanolamine 62-86 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 4-8 2665826-4 1989 The insertion of LPS was probably accompanied by the expulsion of a small portion of phosphatidylcholine molecules from the outer monolayer of LDL into the aqueous medium and by an increase in the phosphatidylethanolamine concentration in LDL. phosphatidylethanolamine 197-221 interferon regulatory factor 6 Homo sapiens 17-20 2647146-2 1989 A disulfide derivative of phosphatidylethanolamine containing a reactive N-hydroxysuccinimide ester group is synthesized, and the derivative is reacted with serum transferrin in deoxycholate-containing buffer. phosphatidylethanolamine 26-50 transferrin Homo sapiens 163-174 2647146-3 1989 Disulfide-linked transferrin-phosphatidylethanolamine conjugates containing up to 6 mol phospholipid/mol protein are prepared. phosphatidylethanolamine 29-53 transferrin Homo sapiens 17-28 2647146-6 1989 Stable incorporation into liposomes requires the introduction of two molecules of phosphatidylethanolamine into the transferrin. phosphatidylethanolamine 82-106 transferrin Homo sapiens 116-127 2647146-7 1989 Using the disulfide linker to release transferrin from the liposomes, evidence is presented for a function of the phosphatidylethanolamine as an anchor-molecule into the liposomal lipid. phosphatidylethanolamine 114-138 transferrin Homo sapiens 38-49 3149278-3 1988 Phosphatidylcholine or phosphatidylethanolamine with arachidonate at the sn-2 position of glycerol was cleaved efficiently by phospholipase A2 activity in homogenates as well as in the cytoplasmic fraction of human platelets, leading to the selective liberation of free arachidonate, whereas phospholipids with linoleate were hardly hydrolyzed under the same conditions. phosphatidylethanolamine 23-47 phospholipase A2 group IB Homo sapiens 126-142 3050446-1 1988 Rhodopsin kinase was purified from bovine retina rod outer segments as a 62-64-kDa protein that phosphorylated purified rhodopsin reconstituted into egg phosphatidylcholine/phosphatidylethanolamine liposomes. phosphatidylethanolamine 173-197 G protein-coupled receptor kinase 7 Bos taurus 0-16 3050446-1 1988 Rhodopsin kinase was purified from bovine retina rod outer segments as a 62-64-kDa protein that phosphorylated purified rhodopsin reconstituted into egg phosphatidylcholine/phosphatidylethanolamine liposomes. phosphatidylethanolamine 173-197 rhodopsin Bos taurus 120-129 2540190-7 1989 The apparent Km for acyl-ACP was 13 microM, and the rate of acyl transfer from this acyl donor was enhanced by the addition of 0.4 M LiCl indicating that the exchange of enzyme-bound ACP for acyl-ACP was a determinant factor in the rate of phosphatidylethanolamine formation from acyl-ACP. phosphatidylethanolamine 240-264 CPAT1 Homo sapiens 25-28 2540190-7 1989 The apparent Km for acyl-ACP was 13 microM, and the rate of acyl transfer from this acyl donor was enhanced by the addition of 0.4 M LiCl indicating that the exchange of enzyme-bound ACP for acyl-ACP was a determinant factor in the rate of phosphatidylethanolamine formation from acyl-ACP. phosphatidylethanolamine 240-264 CPAT1 Homo sapiens 183-186 2540190-7 1989 The apparent Km for acyl-ACP was 13 microM, and the rate of acyl transfer from this acyl donor was enhanced by the addition of 0.4 M LiCl indicating that the exchange of enzyme-bound ACP for acyl-ACP was a determinant factor in the rate of phosphatidylethanolamine formation from acyl-ACP. phosphatidylethanolamine 240-264 CPAT1 Homo sapiens 183-186 2540190-7 1989 The apparent Km for acyl-ACP was 13 microM, and the rate of acyl transfer from this acyl donor was enhanced by the addition of 0.4 M LiCl indicating that the exchange of enzyme-bound ACP for acyl-ACP was a determinant factor in the rate of phosphatidylethanolamine formation from acyl-ACP. phosphatidylethanolamine 240-264 CPAT1 Homo sapiens 183-186 2521797-2 1989 The labeled ATPase has been reconstituted into lipid bilayers containing phosphatidylethanolamine labeled with fluorescein isothiocyanate. phosphatidylethanolamine 73-97 dynein axonemal heavy chain 8 Homo sapiens 12-18 2539092-2 1989 Pulse-chase experiments and measurement of the activities of the enzymes involved in the CDP-ethanolamine pathway provided evidence that the inhibitory effect of glucagon on the synthesis de novo of phosphatidylethanolamine was not caused by a diminished conversion of ethanolamine phosphate into CDP-ethanolamine. phosphatidylethanolamine 199-223 cut-like homeobox 1 Rattus norvegicus 89-92 2539092-3 1989 The observations suggested that the glucagon-induced inhibition of the biosynthesis of phosphatidylethanolamine is probably due to a decreased supply of diacylglycerols, resulting in a decreased formation of phosphatidylethanolamine from CDP-ethanolamine and diacylglycerols. phosphatidylethanolamine 87-111 cut-like homeobox 1 Rattus norvegicus 238-241 2539092-3 1989 The observations suggested that the glucagon-induced inhibition of the biosynthesis of phosphatidylethanolamine is probably due to a decreased supply of diacylglycerols, resulting in a decreased formation of phosphatidylethanolamine from CDP-ethanolamine and diacylglycerols. phosphatidylethanolamine 208-232 cut-like homeobox 1 Rattus norvegicus 238-241 2922759-5 1989 In a related study, purified phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were also found to activate the partially separated NTE activity in a concentration-dependent manner while phosphatidyl-inositol was found to inhibit the same partially separated NTE fraction in a concentration-dependent manner. phosphatidylethanolamine 50-74 patatin like phospholipase domain containing 6 Gallus gallus 151-154 2922759-5 1989 In a related study, purified phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine were also found to activate the partially separated NTE activity in a concentration-dependent manner while phosphatidyl-inositol was found to inhibit the same partially separated NTE fraction in a concentration-dependent manner. phosphatidylethanolamine 50-74 patatin like phospholipase domain containing 6 Gallus gallus 278-281 2914139-0 1989 Aminophospholipid translocase in the plasma membrane of Friend erythroleukemic cells can induce an asymmetric topology for phosphatidylserine but not for phosphatidylethanolamine. phosphatidylethanolamine 154-178 ATPase, class I, type 8B, member 1 Mus musculus 0-29 2500989-4 1989 Phospholipase A2 is activated by a variety of physical and chemical agents (e.g. infection, trauma) that increase calcium concentrations in the cell; it releases arachidonic acid from phosphatidyl-choline and phosphatidyl-ethanolamine in particular. phosphatidylethanolamine 209-234 phospholipase A2 group IB Homo sapiens 0-16 2519886-2 1989 A comparative study on phospholipase A2 activity in platelet lysates from various species was carried out using identical assay conditions with phosphatidylethanolamine as substrate. phosphatidylethanolamine 144-168 phospholipase A2 group IB Rattus norvegicus 23-39 3223955-3 1988 The only known mammalian pathway for the synthesis de novo of choline molecules is catalysed by phosphatidylethanolamine N-methyltransferase (PeMT), which synthesizes phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor. phosphatidylethanolamine 96-120 phosphatidylethanolamine N-methyltransferase Homo sapiens 142-146 3223955-3 1988 The only known mammalian pathway for the synthesis de novo of choline molecules is catalysed by phosphatidylethanolamine N-methyltransferase (PeMT), which synthesizes phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor. phosphatidylethanolamine 252-258 phosphatidylethanolamine N-methyltransferase Homo sapiens 96-140 3223955-3 1988 The only known mammalian pathway for the synthesis de novo of choline molecules is catalysed by phosphatidylethanolamine N-methyltransferase (PeMT), which synthesizes phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor. phosphatidylethanolamine 252-258 phosphatidylethanolamine N-methyltransferase Homo sapiens 142-146 3146971-3 1988 In studies of the effect on PA synthesis de novo, insulin stimulated [2-3H]glycerol incorporation into PA, DAG, PC/PE and total glycerolipids of BC3H-1 myocytes, regardless of whether insulin was added simultaneously with, or after 2 h or 3 or 10 days of prelabelling with, [2-3H]glycerol. phosphatidylethanolamine 115-117 insulin Homo sapiens 50-57 3139038-2 1988 The sigmoidal shape of the activation curve was eliminated by neutral lipids such as phosphatidylcholine and phosphatidylethanolamine, detergents such as Triton X-100 or by an aggregated form of alpha-lactalbumin generated by crosslinking alpha-lactalbumin with dithiobissuccinimidylpropionate. phosphatidylethanolamine 109-133 lactalbumin alpha Bos taurus 195-212 3139038-2 1988 The sigmoidal shape of the activation curve was eliminated by neutral lipids such as phosphatidylcholine and phosphatidylethanolamine, detergents such as Triton X-100 or by an aggregated form of alpha-lactalbumin generated by crosslinking alpha-lactalbumin with dithiobissuccinimidylpropionate. phosphatidylethanolamine 109-133 lactalbumin alpha Bos taurus 239-256 3417866-3 1988 Exogenous PLA2 did not produce any significant change in various metabolic parameters reflective of cell injury in control nonhypoxic preparations despite a significant decrease in phosphatidylethanolamine (PE) and moderate increases in lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE). phosphatidylethanolamine 181-205 phospholipase A2 Oryctolagus cuniculus 10-14 3417866-4 1988 In contrast, exogenous PLA2 treatment of hypoxic tubules resulted in a severe degree of cell injury, as demonstrated by marked declines in tubule K+ and ATP contents and significant decreases in tubule uncoupled respiratory rates, and was associated with significant phospholipid alterations, including marked declines in phosphatidylcholine (PC) and PE and significant rises in LPC, LPE, and free fatty acids (FFA). phosphatidylethanolamine 351-353 phospholipase A2 Oryctolagus cuniculus 23-27 3417866-3 1988 Exogenous PLA2 did not produce any significant change in various metabolic parameters reflective of cell injury in control nonhypoxic preparations despite a significant decrease in phosphatidylethanolamine (PE) and moderate increases in lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE). phosphatidylethanolamine 207-209 phospholipase A2 Oryctolagus cuniculus 10-14 3219348-4 1988 Rhodopsin photochemical activity is enhanced by phosphatidylethanolamine head groups and docosahexaenoyl (22:6 omega 3) acyl chains. phosphatidylethanolamine 48-72 rhodopsin Homo sapiens 0-9 2852015-8 1988 Secreted apo AI is associated mainly with newly synthesized phosphatidylethanolamine and little triglyceride, apo AII with phosphatidylethanolamine, lysophosphatidylethanolamine and neutral lipids. phosphatidylethanolamine 60-84 apolipoprotein A-I S homeolog Xenopus laevis 9-15 2852015-8 1988 Secreted apo AI is associated mainly with newly synthesized phosphatidylethanolamine and little triglyceride, apo AII with phosphatidylethanolamine, lysophosphatidylethanolamine and neutral lipids. phosphatidylethanolamine 123-147 apolipoprotein A-I S homeolog Xenopus laevis 9-15 3130896-7 1988 It is concluded that in hepatocytes vasopressin increases diacylglycerols by a process which does not principally involve the conversion of phosphoinositides to diacylglycerol or the de novo synthesis of diacylglycerol from glycerol 3-phosphate, but does involve the Ca2+-dependent conversion of phosphatidylethanolamine and phosphatidylcholine to diacylglycerol. phosphatidylethanolamine 296-320 arginine vasopressin Homo sapiens 36-47 2971392-6 1988 In one such case involving liposomes composed of PA/PS/PE/phosphatidylcholine (PC) (10:15:65:10), synexin reduced the fusion rate constant by 50%. phosphatidylethanolamine 55-57 annexin A7 Homo sapiens 98-105 3131322-1 1988 The kinetics of the Ca2+-dependent, alkaline pH optimum, membrane-bound phospholipase A2 from the P388D1 macrophage-like cell line were studied using various phosphatidylcholine (PC) and phosphatidylethanolamine (PE) substrates. phosphatidylethanolamine 213-215 phospholipase A2, group IB, pancreas Mus musculus 72-88 3128327-0 1988 beta-Galactosidase-induced destabilization of liposome composed of phosphatidylethanolamine and ganglioside GM1. phosphatidylethanolamine 67-91 galactosidase beta 1 Homo sapiens 0-18 3133132-6 1988 In hypoxic myocardium, this phospholipase A2 activity markedly increased and had substrate specificity toward phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 134-158 phospholipase A2 group IB Rattus norvegicus 28-44 3377797-5 1988 Cholecystokinin increased the incorporation of both [U-14C] glucose and 32P into phosphatidyl ethanolamine 3-fold but had no effect on 32P incorporation into phosphatidyl choline. phosphatidylethanolamine 81-106 cholecystokinin Rattus norvegicus 0-15 2833521-19 1988 The results support the hypothesis that Golgi has the capacity to make certain phospholipids for lipoprotein secretion: phosphatidylcholine via the CDP-choline and methylation pathways, phosphatidylethanolamine by the CDP-ethanolamine pathway, and phosphatidylserine. phosphatidylethanolamine 186-210 cut-like homeobox 1 Rattus norvegicus 218-221 3126497-11 1988 In contrast, both class I MHC proteins and fluorescein-labeled phosphatidylethanolamine diffused isotropically on interferon-gamma-treated HEC. phosphatidylethanolamine 63-87 interferon gamma Homo sapiens 114-130 3124978-2 1988 Stable liposomes with entrapped glucose-6-phosphate dehydrogenase (G6PDH) were prepared with unsaturated PE stabilized with 5 mol percent of ganglioside GM1. phosphatidylethanolamine 105-107 glucose-6-phosphate dehydrogenase Homo sapiens 32-65 3342248-1 1988 The influence of variation of the phospholipid composition in model membranes composed of phosphatidylcholine and phosphatidylethanolamine on the hydrolysis of these phospholipids by rat liver mitochondrial phospholipase A2 was investigated. phosphatidylethanolamine 114-138 phospholipase A2 group IB Rattus norvegicus 207-223 3123482-2 1988 We have studied the phospholipase A2 activity in fractionated human neutrophils, employing labeled phosphatidylinositol, phosphatidylcholine, and phosphatidylethanolamine as exogenous substrates. phosphatidylethanolamine 146-170 phospholipase A2 group IB Homo sapiens 20-36 3123482-10 1988 Phosphatidylinositol was a better substrate for the plasma membrane enzyme, whereas phosphatidylcholine and phosphatidylethanolamine behaved as better substrates for intracellular organelle phospholipase A2 activities. phosphatidylethanolamine 108-132 phospholipase A2 group IB Homo sapiens 190-206 3124978-2 1988 Stable liposomes with entrapped glucose-6-phosphate dehydrogenase (G6PDH) were prepared with unsaturated PE stabilized with 5 mol percent of ganglioside GM1. phosphatidylethanolamine 105-107 glucose-6-phosphate dehydrogenase Homo sapiens 67-72 3121598-3 1987 The presence of a net negative charge on the phospholipid headgroup is essential for activation, since lipid vesicles consisting exclusively of zwitterionic phospholipids, such as phosphatidylcholine and phosphatidylethanolamine, do not activate PAI-1. phosphatidylethanolamine 204-228 serpin family E member 1 Homo sapiens 246-251 2446664-4 1988 However, myelin basic protein was labeled 2-4-times more when bound to the acidic lipids phosphatidylglycerol, phosphatidylserine, phosphatidic acid, and cerebroside sulfate than when bound to phosphatidylethanolamine, or when in solution in the presence of phosphatidylcholine vesicles. phosphatidylethanolamine 193-217 myelin basic protein Homo sapiens 9-29 3119709-8 1987 All glycerol-derived cell membrane phospholipids examined (phosphatidylethanolamine, -inositol, -choline, and -serine) incorporated labeled AA which was releasable by treatment with PLA2. phosphatidylethanolamine 59-83 phospholipase A2, group IB, pancreas Mus musculus 182-186 2829843-2 1987 Reconstitution of the receptor kinase into leaky vesicles containing phosphatidylcholine and phosphatidylethanolamine (1:1, w/w) by detergent removal on Sephadex G-50 results in the complete loss of receptor kinase sensitivity to activation by insulin. phosphatidylethanolamine 93-117 insulin Homo sapiens 244-251 2829843-9 1987 These data indicate that the phospholipid environment of insulin receptors can modulate its binding and kinase activity, and phosphatidylserine acts to restore insulin-sensitivity to the receptor kinase incorporated into phosphatidylcholine/phosphatidylethanolamine vesicles. phosphatidylethanolamine 241-265 insulin Homo sapiens 57-64 2829843-9 1987 These data indicate that the phospholipid environment of insulin receptors can modulate its binding and kinase activity, and phosphatidylserine acts to restore insulin-sensitivity to the receptor kinase incorporated into phosphatidylcholine/phosphatidylethanolamine vesicles. phosphatidylethanolamine 241-265 insulin Homo sapiens 160-167 2833432-4 1988 The results of the study indicate that stimulation of 1-14C-AA-prelabelled PMNs with BK liberates AA mainly from phosphatidylinositol, while A23187 causes release of AA from phosphatidylcholine, phosphatidylethanolamine, and possibly phosphatidylserine. phosphatidylethanolamine 195-219 kininogen 1 Homo sapiens 85-87 3117114-1 1987 In previous publications, we have shown, by using spin-labeled derivatives, that the translocation of phosphatidylserine and phosphatidylethanolamine from the outer to the inner monolayer of human erythrocyte membrane is a protein-mediated phenomenon, which requires hydrolisable Mg2+-ATP. phosphatidylethanolamine 125-149 mucin 7, secreted Homo sapiens 280-283 3118953-1 1987 NADPH-cytochrome P-450 reductase, purified from bovine adrenocortical microsomes, was shown to bind in two different modes to liposomal membranes composed of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine at a molar ratio of 5:3:1. phosphatidylethanolamine 179-203 cytochrome p450 oxidoreductase Bos taurus 0-32 2959320-6 1987 Vesicle sizes changed little with changing phosphatidylethanolamine content, and the sidedness of insertion of the ATPase was close to random at all phosphatidylethanolamine contents. phosphatidylethanolamine 149-173 dynein axonemal heavy chain 8 Homo sapiens 115-121 2959320-7 1987 It is suggested that the effect of phosphatidylethanolamine on the level of Ca2+ accumulation follows from an effect on the rate of Ca2+ efflux mediated by the ATPase. phosphatidylethanolamine 35-59 dynein axonemal heavy chain 8 Homo sapiens 160-166 2959321-2 1987 The permeability of lipid bilayers to Co2+ and glucose was increased slightly by incorporation of the ATPase, and the permeability of mixed bilayers of phosphatidylethanolamine and phosphatidylcholine increased with increasing content of phosphatidylethanolamine both in the presence and absence of the ATPase. phosphatidylethanolamine 152-176 dynein axonemal heavy chain 8 Homo sapiens 303-309 2959321-2 1987 The permeability of lipid bilayers to Co2+ and glucose was increased slightly by incorporation of the ATPase, and the permeability of mixed bilayers of phosphatidylethanolamine and phosphatidylcholine increased with increasing content of phosphatidylethanolamine both in the presence and absence of the ATPase. phosphatidylethanolamine 238-262 dynein axonemal heavy chain 8 Homo sapiens 303-309 2959321-3 1987 The presence of the ATPase, however, resulted in a marked increase in permeability to Ca2+, the permeability decreasing with increasing phosphatidylethanolamine content. phosphatidylethanolamine 136-160 dynein axonemal heavy chain 8 Homo sapiens 20-26 2959321-7 1987 It is shown that the effects of phosphatidylethanolamine on efflux can be simulated in terms of changes in the rates of the transitions linking conformations of the ATPase with inward- and outward-facing Ca2+-binding sites, and that effects of phosphatidylethanolamine on the ATPase activity of the ATPase can also be simulated in terms of effects on the corresponding conformational transitions. phosphatidylethanolamine 32-56 dynein axonemal heavy chain 8 Homo sapiens 165-171 2959321-7 1987 It is shown that the effects of phosphatidylethanolamine on efflux can be simulated in terms of changes in the rates of the transitions linking conformations of the ATPase with inward- and outward-facing Ca2+-binding sites, and that effects of phosphatidylethanolamine on the ATPase activity of the ATPase can also be simulated in terms of effects on the corresponding conformational transitions. phosphatidylethanolamine 32-56 dynein axonemal heavy chain 8 Homo sapiens 276-282 2959321-7 1987 It is shown that the effects of phosphatidylethanolamine on efflux can be simulated in terms of changes in the rates of the transitions linking conformations of the ATPase with inward- and outward-facing Ca2+-binding sites, and that effects of phosphatidylethanolamine on the ATPase activity of the ATPase can also be simulated in terms of effects on the corresponding conformational transitions. phosphatidylethanolamine 32-56 dynein axonemal heavy chain 8 Homo sapiens 276-282 2959321-7 1987 It is shown that the effects of phosphatidylethanolamine on efflux can be simulated in terms of changes in the rates of the transitions linking conformations of the ATPase with inward- and outward-facing Ca2+-binding sites, and that effects of phosphatidylethanolamine on the ATPase activity of the ATPase can also be simulated in terms of effects on the corresponding conformational transitions. phosphatidylethanolamine 244-268 dynein axonemal heavy chain 8 Homo sapiens 165-171 2445736-2 1987 The structural genes (PEM1 and PEM2) encoding the enzymes involved in the yeast phosphatidylethanolamine (PE) methylation pathway were cloned by means of genetic complementation using yeast mutants. phosphatidylethanolamine 80-104 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 22-26 2820988-3 1987 Target sensitivity of phosphatidylethanolamine (PE) immunoliposomes is a result of the ability of acylated monoclonal anti-HSV glycoprotein D (gD) to stabilize the bilayer phase of PE, whereas by itself, PE does not form stable liposomes (Ho, R. J. Y., Rouse, B. T., and Huang, L. (1986) Biochemistry 25, 5500-5506). phosphatidylethanolamine 22-46 atypical chemokine receptor 1 (Duffy blood group) Homo sapiens 127-141 2445736-2 1987 The structural genes (PEM1 and PEM2) encoding the enzymes involved in the yeast phosphatidylethanolamine (PE) methylation pathway were cloned by means of genetic complementation using yeast mutants. phosphatidylethanolamine 80-104 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 31-35 2446313-9 1987 CAT activity in RDM-4 cells from mice injected with DNA entrapped in pH-insensitive immunoliposomes (containing phosphatidylcholine in place of phosphatidylethanolamine) was approximately one-fourth that in RDM-4 cells from mice injected with pH-sensitive immunoliposomes, indicating the superior delivery efficiency of the pH-sensitive liposomes. phosphatidylethanolamine 144-168 chloramphenicol acetyltransferase Escherichia coli 0-3 2820988-3 1987 Target sensitivity of phosphatidylethanolamine (PE) immunoliposomes is a result of the ability of acylated monoclonal anti-HSV glycoprotein D (gD) to stabilize the bilayer phase of PE, whereas by itself, PE does not form stable liposomes (Ho, R. J. Y., Rouse, B. T., and Huang, L. (1986) Biochemistry 25, 5500-5506). phosphatidylethanolamine 48-50 atypical chemokine receptor 1 (Duffy blood group) Homo sapiens 127-141 2954856-4 1987 Inhibition gradually decreased with increasing substrate concentrations both for pancreatic and platelet phospholipase A2 and became completely abolished above 15 and 50 microM phosphatidylethanolamine, respectively. phosphatidylethanolamine 177-201 phospholipase A2 group IIA Rattus norvegicus 96-121 2957692-7 1987 In addition, endonexin II bound to phosphatidylserine- and phosphatidylethanolamine-containing liposomes in a Ca2+-dependent manner, and the binding was cooperative with respect to Ca2+ concentration (Hill constant greater than 3). phosphatidylethanolamine 59-83 annexin A5 Homo sapiens 13-25 3109482-13 1987 It was concluded that rat brush-border membranes contain a Ca2+-independent phospholipase A2 with a high substrate preference for phosphatidylethanolamine. phosphatidylethanolamine 130-154 phospholipase A2 group IB Rattus norvegicus 76-92 3038645-2 1987 Although phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine also increased insulin receptor autophosphorylation, only phosphatidylinositol (PtdIns) stimulated to a similar extent as the phospholipid mixture. phosphatidylethanolamine 30-54 insulin receptor Homo sapiens 93-109 2953727-4 1987 These PMN proteins, like bovine liver synexin, promoted aggregation of isolated PMN specific granules in the presence of Ca2+ and increased the overall rate of Ca2+-induced fusion of liposomes composed of phosphatidate (PA)/phosphatidylethanolamine (PE) (1:3) and phosphatidylserine/PE (1:3), but decreased the rate of spermine-induced fusion of PA/PE (1:3) liposomes. phosphatidylethanolamine 224-248 annexin A7 Bos taurus 38-45 2953727-4 1987 These PMN proteins, like bovine liver synexin, promoted aggregation of isolated PMN specific granules in the presence of Ca2+ and increased the overall rate of Ca2+-induced fusion of liposomes composed of phosphatidate (PA)/phosphatidylethanolamine (PE) (1:3) and phosphatidylserine/PE (1:3), but decreased the rate of spermine-induced fusion of PA/PE (1:3) liposomes. phosphatidylethanolamine 250-252 annexin A7 Bos taurus 38-45 2953727-4 1987 These PMN proteins, like bovine liver synexin, promoted aggregation of isolated PMN specific granules in the presence of Ca2+ and increased the overall rate of Ca2+-induced fusion of liposomes composed of phosphatidate (PA)/phosphatidylethanolamine (PE) (1:3) and phosphatidylserine/PE (1:3), but decreased the rate of spermine-induced fusion of PA/PE (1:3) liposomes. phosphatidylethanolamine 283-285 annexin A7 Bos taurus 38-45 2953727-4 1987 These PMN proteins, like bovine liver synexin, promoted aggregation of isolated PMN specific granules in the presence of Ca2+ and increased the overall rate of Ca2+-induced fusion of liposomes composed of phosphatidate (PA)/phosphatidylethanolamine (PE) (1:3) and phosphatidylserine/PE (1:3), but decreased the rate of spermine-induced fusion of PA/PE (1:3) liposomes. phosphatidylethanolamine 283-285 annexin A7 Bos taurus 38-45 2953727-5 1987 Using fluorescent lipid probes, rapid fusion of PA/PE liposomes with PMN specific granules (50% maximum signal within a few minutes) was observed when 1 mM Ca2+ was added in the presence of both synexin and free arachidonic acid. phosphatidylethanolamine 51-53 annexin A7 Homo sapiens 195-202 3661986-3 1987 The T-2 mycotoxin was converted to an acid chloride derivative, subsequently coupled to the amino group of phosphatidylethanolamine, and incorporated with the phospholipid into unilamellar liposomes. phosphatidylethanolamine 107-131 solute carrier family 25 member 5 Homo sapiens 4-7 3034067-5 1987 These data postulate that phosphatidylethanolamine synthesis by the base exchange reaction may be the precursor of transmethylation and its subsequent activation of phospholipase A2, leading to the induction of arachidonic acid cascade. phosphatidylethanolamine 26-50 phospholipase A2 group IB Homo sapiens 165-181 3598396-11 1987 Postheparin plasma rapidly hydrolyzed chylomicron 3H-labeled and 14C-labeled phosphatidylethanolamine to the same degree, and lipoprotein lipase similarly hydrolyzed 3H-labeled and 14C-labeled phosphatidylethanolamine at approximately equal rates. phosphatidylethanolamine 193-217 lipoprotein lipase Bos taurus 126-144 3598396-12 1987 Antiserum to hepatic lipase inhibited the postheparin plasma hydrolysis of phosphatidylethanolamine and 3H-labeled phosphatidylcholine by about 60%, but the 14C-labeled phosphatidylcholine by only 27%. phosphatidylethanolamine 75-99 lipase C, hepatic type Bos taurus 13-27 3549734-3 1987 This stimulatory protein was stable for several months when frozen at -70 degrees C. The purified protein selectively stimulated phospholipase A2 when phosphatidylcholine was used as a substrate but had no effect on phospholipase A2 activity when phosphatidylethanolamine was used as a substrate. phosphatidylethanolamine 247-271 phospholipase A2 group IB Homo sapiens 129-145 3818590-6 1987 In the present study, the toxin-membrane interaction was distinguished from the hexamer formation by the fluorescence energy transfer from the tryptophan residue(s) of the toxin molecule to the dansylated phosphatidylethanolamine in phosphatidylcholine liposome. phosphatidylethanolamine 205-229 AT695_RS01930 Staphylococcus aureus 26-31 3818590-6 1987 In the present study, the toxin-membrane interaction was distinguished from the hexamer formation by the fluorescence energy transfer from the tryptophan residue(s) of the toxin molecule to the dansylated phosphatidylethanolamine in phosphatidylcholine liposome. phosphatidylethanolamine 205-229 AT695_RS01930 Staphylococcus aureus 172-177 3828111-8 1987 The results suggest the possibility that changes in the levels of liver CTP may play a role in regulation of the cytidine pathway of liver phosphatidylcholine synthesis but not of phosphatidylethanolamine synthesis, because the latter pathway appears to be tightly controlled at the ethanolaminephosphotransferase step. phosphatidylethanolamine 180-204 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 72-75 3104714-7 1987 Thus, HPLC methodology indicates that arachidonoyl-containing molecular species of phosphatidylcholine and phosphatidylethanolamine are the major source of arachidonic acid in thrombin-stimulated human platelets, while certain ether phospholipid molecular species become enriched in arachidonate. phosphatidylethanolamine 107-131 coagulation factor II, thrombin Homo sapiens 176-184 3024736-4 1987 Angiotensin II also decreased the 3H radioactivity of PIP slightly only at 15 s and increased that of phosphatidic acid after 15 s, with no significant effect upon the labelings of phosphatidylinositol (PI), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) within 1 min. phosphatidylethanolamine 237-261 angiotensinogen Rattus norvegicus 0-14 3024736-4 1987 Angiotensin II also decreased the 3H radioactivity of PIP slightly only at 15 s and increased that of phosphatidic acid after 15 s, with no significant effect upon the labelings of phosphatidylinositol (PI), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) within 1 min. phosphatidylethanolamine 263-265 angiotensinogen Rattus norvegicus 0-14 3790604-2 1987 By using rat-liver mitochondria containing labeled phosphatidylethanolamine and inactivated phospholipase A2 as substrate source, and mitochondria containing unlabeled substrate and active enzyme, it is shown that hydrolysis of phosphatidylethanolamine by mitochondrial phospholipase A2 proceeds nearly entirely via intramembrane enzyme action. phosphatidylethanolamine 228-252 phospholipase A2 group IB Rattus norvegicus 92-108 3790604-2 1987 By using rat-liver mitochondria containing labeled phosphatidylethanolamine and inactivated phospholipase A2 as substrate source, and mitochondria containing unlabeled substrate and active enzyme, it is shown that hydrolysis of phosphatidylethanolamine by mitochondrial phospholipase A2 proceeds nearly entirely via intramembrane enzyme action. phosphatidylethanolamine 228-252 phospholipase A2 group IB Rattus norvegicus 270-286 3790605-1 1987 Evidence is provided in this paper to indicate that hydrolysis of exogenously added phosphatidylethanolamine and phosphatidylcholine by the membrane-bound phospholipase A2 from rat-liver mitochondria is preceded by association of the substrates with the membranes. phosphatidylethanolamine 84-108 phospholipase A2 group IB Rattus norvegicus 155-171 3593300-3 1987 Membrane PL organization was detected by Bee venom phospholipase-A2 (Plase) treatment, which specifically hydrolyzes outer bilayer phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylcholine (PC). phosphatidylethanolamine 156-180 phospholipase A2 group IB Homo sapiens 51-67 3593300-3 1987 Membrane PL organization was detected by Bee venom phospholipase-A2 (Plase) treatment, which specifically hydrolyzes outer bilayer phosphatidylserine (PS), phosphatidylethanolamine (PE), and phosphatidylcholine (PC). phosphatidylethanolamine 182-184 phospholipase A2 group IB Homo sapiens 51-67 3718986-6 1986 In cells pre-treated with NaNO2 to convert hemoglobin to methemoglobin, t-butyl hydroperoxide reduces [9,10-3H]oleic acid incorporation into phosphatidylcholine by erythrocytes but does not stimulate [9,10-3H]oleic acid incorporation into phosphatidylethanolamine. phosphatidylethanolamine 239-263 hemoglobin subunit gamma 2 Homo sapiens 57-70 3026684-2 1987 In this study I show that: incorporation of ammonium sulfate into silica gel "GHL" has a dramatic effect on separation of lung phospholipids; this effect is equally dramatic but different in activated and nonactivated gels; when it picks up moisture, ammonium sulfate-activated gel very rapidly loses its ability to resolve lecithin from phosphatidylinositol; in gel containing ammonium sulfate, small amounts of phosphatidylethanolamine are hydrolyzed to lyso-phosphatidylethanolamine. phosphatidylethanolamine 413-437 growth hormone 2 Homo sapiens 78-81 3102272-10 1986 Outer-segment phosphatidylethanolamine steadily increased in palmitate label throughout the 12-day period, suggesting that phosphatidylethanolamine may be utilized for recapture of palmitate released from breakdown of palmitate esters of rhodopsin or vitamin A or from phospholipids. phosphatidylethanolamine 123-147 rhodopsin Rattus norvegicus 238-247 3025802-1 1986 Human lymphocyte and granulocyte membranes contain an enzyme, phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the transfer of a methyl group from S-adenosylmethionine to the polar head group of phosphatidylethanolamine to form phosphatidylmonomethylethanolamine. phosphatidylethanolamine 62-86 phosphatidylethanolamine N-methyltransferase Homo sapiens 108-112 2434471-3 1986 Purified PLA2 had absolute 2-acyl specificity, and hydrolyzed phosphatidylcholine with optimal activity at pH 7.5-8.0 and phosphatidylethanolamine with optimal activity at pH 7.0. phosphatidylethanolamine 122-146 phospholipase A2 group IB Homo sapiens 9-13 3117782-4 1987 These results demonstrate that phospholipase A (PLA) preferentially acts on PI to release arachidonic acid which leads to the initial TXA2 production, which might be a trigger for the second release of arachidonic acid from PE and PI. phosphatidylethanolamine 224-226 phospholipase A and acyltransferase 1 Rattus norvegicus 31-46 3117782-4 1987 These results demonstrate that phospholipase A (PLA) preferentially acts on PI to release arachidonic acid which leads to the initial TXA2 production, which might be a trigger for the second release of arachidonic acid from PE and PI. phosphatidylethanolamine 224-226 phospholipase A and acyltransferase 1 Rattus norvegicus 48-51 3022648-7 1986 PE formation in both neutrophil and lymphocyte base-exchange reactions was enhanced in a dose-dependent manner by the presence of low concentrations of bioactive stimulants (zymosan, 0.05-0.2 mg/ml; Con A, 0.5-2 micrograms/ml), while EPT and CPT activities were not increased by these cell stimulants. phosphatidylethanolamine 0-2 choline phosphotransferase 1 Homo sapiens 242-245 3021886-2 1986 Fifteen seconds following thrombin addition (15 U/5 X 10(9) platelets), phosphatidylcholine lost 11.8 nmol of arachidonate and phosphatidylethanolamine lost 10.5 nmol. phosphatidylethanolamine 127-151 coagulation factor II, thrombin Homo sapiens 26-34 3729424-4 1986 This phospholipase A2 had substrate specificity toward phosphatidylethanolamine. phosphatidylethanolamine 55-79 phospholipase A2 group IB Rattus norvegicus 5-21 17007793-3 1986 It was also revealed that the regeneration of rhodopsin was perturbed by the formation of retinylidene Schiff base with phosphatidylethanolamine in rod outer segment membranes, which decreased with increasing temperature. phosphatidylethanolamine 120-144 rhodopsin Homo sapiens 46-55 3957923-0 1986 An apo-E-free very low density lipoprotein enriched in phosphatidylethanolamine in human plasma. phosphatidylethanolamine 55-79 apolipoprotein E Homo sapiens 3-8 3456745-6 1986 This inhibition reduces the production of cell membrane lyso-phosphatidylcholine (PC) and arachidonic acid from PC, which is produced by transmethylation of PE and cytidine diphosphate (CDP) choline pathway of which the last reaction to PC is mediated by CPT. phosphatidylethanolamine 157-159 choline phosphotransferase 1 Homo sapiens 255-258 3957904-2 1986 In liver, phosphatidylcholine is made both by the CDP-choline pathway and by the methylation of phosphatidylethanolamine, which in turn is derived from both serine (via phosphatidylserine) and ethanolamine (via CDP-ethanolamine). phosphatidylethanolamine 96-120 cut-like homeobox 1 Rattus norvegicus 211-214 3949762-1 1986 Purification of human platelet phospholipase A2 (PLA2) from a particulate fraction by ion-exchange chromatography at 4 degrees C yielded a single peak of enzyme activity, which catalyzed the hydrolysis of arachidonic acid from the 2-position of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 278-302 phospholipase A2 group IIA Homo sapiens 49-53 3089288-2 1986 Only a minute activity of phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) could be detected using externally added phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as substrate. phosphatidylethanolamine 155-179 LOC104974671 Bos taurus 26-42 3089288-2 1986 Only a minute activity of phospholipase A2 (phosphatide 2-acylhydrolase, EC 3.1.1.4) could be detected using externally added phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as substrate. phosphatidylethanolamine 181-183 LOC104974671 Bos taurus 26-42 3949762-1 1986 Purification of human platelet phospholipase A2 (PLA2) from a particulate fraction by ion-exchange chromatography at 4 degrees C yielded a single peak of enzyme activity, which catalyzed the hydrolysis of arachidonic acid from the 2-position of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 304-310 phospholipase A2 group IIA Homo sapiens 49-53 2413014-3 1985 Addition of phosphatidylethanolamine (PE) or phosphatidylserine to the reconstitution mixture restores high affinity LqTx binding with KD = 1.9 nM for PC/PE vesicles at -90 mV and 36 degrees C in sucrose-substituted medium. phosphatidylethanolamine 12-36 procollagen C-endopeptidase enhancer Rattus norvegicus 151-156 3964311-4 1986 Enhanced PLA2 activities were observed in RA patient cells when phosphatidylcholine (PC) or phosphatidylethanolamine (PE) were used as substrates. phosphatidylethanolamine 92-116 phospholipase A2 group IB Homo sapiens 9-13 3964311-4 1986 Enhanced PLA2 activities were observed in RA patient cells when phosphatidylcholine (PC) or phosphatidylethanolamine (PE) were used as substrates. phosphatidylethanolamine 118-120 phospholipase A2 group IB Homo sapiens 9-13 4087304-1 1985 Synthesis of phosphatidylcholine (PC) by S-adenosyl-L-methionine (AdoMet)-dependent methylation of phosphatidylethanolamine (PE) has been recently characterized in rat heart sarcolemma obtained by hypotonic shock-LiBr treatment method. phosphatidylethanolamine 99-123 methionine adenosyltransferase 1A Rattus norvegicus 41-64 4087304-1 1985 Synthesis of phosphatidylcholine (PC) by S-adenosyl-L-methionine (AdoMet)-dependent methylation of phosphatidylethanolamine (PE) has been recently characterized in rat heart sarcolemma obtained by hypotonic shock-LiBr treatment method. phosphatidylethanolamine 99-123 methionine adenosyltransferase 1A Rattus norvegicus 66-72 4087304-1 1985 Synthesis of phosphatidylcholine (PC) by S-adenosyl-L-methionine (AdoMet)-dependent methylation of phosphatidylethanolamine (PE) has been recently characterized in rat heart sarcolemma obtained by hypotonic shock-LiBr treatment method. phosphatidylethanolamine 125-127 methionine adenosyltransferase 1A Rattus norvegicus 41-64 4087304-1 1985 Synthesis of phosphatidylcholine (PC) by S-adenosyl-L-methionine (AdoMet)-dependent methylation of phosphatidylethanolamine (PE) has been recently characterized in rat heart sarcolemma obtained by hypotonic shock-LiBr treatment method. phosphatidylethanolamine 125-127 methionine adenosyltransferase 1A Rattus norvegicus 66-72 2413893-1 1985 Myelin basic protein induces slow and limited fusion of phospholipid vesicles composed of a mixture of phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 127-151 myelin basic protein Homo sapiens 0-20 3000036-3 1985 Bee venom phospholipase A2 is more effective than cobra venom phospholipase A2, the both phospholipases splitting phosphatidylethanolamine most intensively. phosphatidylethanolamine 114-138 phospholipase A2 group IB Homo sapiens 10-26 3000036-3 1985 Bee venom phospholipase A2 is more effective than cobra venom phospholipase A2, the both phospholipases splitting phosphatidylethanolamine most intensively. phosphatidylethanolamine 114-138 phospholipase A2 group IB Homo sapiens 62-78 2990564-1 1985 The Ca2+ dependent incorporation of [14C]ethanolamine, L-[14C]serine and [14C]choline into phosphatidylethanolamine, phosphatidylserine and phosphatidylcholine, respectively, were investigated in membrane preparations from rat heart. phosphatidylethanolamine 91-115 carbonic anhydrase 2 Rattus norvegicus 4-7 3925027-3 1985 Common to the three substances, phosphatidylinositol, phosphatidylethanolamine, and phosphatidylcholine almost equally served as sources of arachidonate liberated by the action of phospholipase A2. phosphatidylethanolamine 54-78 phospholipase A2, group IB, pancreas Mus musculus 180-196 3995060-4 1985 As well, concentrations of plasma membrane phosphatidylcholine and phosphatidylethanolamine in thrombin-stimulated platelets decreased by 20 and 9%, respectively, when compared with their control values. phosphatidylethanolamine 67-91 coagulation factor II, thrombin Homo sapiens 95-103 4096905-1 1985 Cytochrome b5 induced flip-flop of phosphatidylethanolamine (PE) in sonicated vesicles prepared from a 9:1 mixture of phosphatidylcholine (PC) to phosphatidylethanolamine was determined as follows. phosphatidylethanolamine 35-59 cytochrome b5 type A Homo sapiens 0-13 4096905-1 1985 Cytochrome b5 induced flip-flop of phosphatidylethanolamine (PE) in sonicated vesicles prepared from a 9:1 mixture of phosphatidylcholine (PC) to phosphatidylethanolamine was determined as follows. phosphatidylethanolamine 61-63 cytochrome b5 type A Homo sapiens 0-13 4096905-1 1985 Cytochrome b5 induced flip-flop of phosphatidylethanolamine (PE) in sonicated vesicles prepared from a 9:1 mixture of phosphatidylcholine (PC) to phosphatidylethanolamine was determined as follows. phosphatidylethanolamine 146-170 cytochrome b5 type A Homo sapiens 0-13 2418024-11 1986 (i) EGF-dependent tyrosine phosphorylation of the EGF receptor and its inhibition by GM3 were also demonstrated on isolated EGF receptor after adsorption on the anti-receptor antibody-Sepharose complex, and the receptor phosphorylation was enhanced on addition of phosphatidylethanolamine. phosphatidylethanolamine 264-288 epidermal growth factor receptor Homo sapiens 50-62 4091805-1 1985 The activity of phosphatidylethanolamine N-methyltransferase (PeMT), an enzymic system that catalyses the synthesis of phosphatidylcholine (PtdCho) via sequential methylation of phosphatidylethanolamine (PtdEtn) using S-adenosylmethionine (AdoMet) as a methyl donor, was examined in brain homogenates from rats of various ages. phosphatidylethanolamine 204-210 phosphatidylethanolamine N-methyltransferase Homo sapiens 16-60 3862730-4 1985 Peripheral blood PMN from patients with RA (RA-PMN) exhibit greater phospholipase A2 activities against phosphatidylcholine (PC) and phosphatidylethanolamine (PE), and greater phospholipase C activities against PC, PE, and phosphatidylinositol (PI) than PMN obtained from normal volunteers (N-PMN). phosphatidylethanolamine 133-157 phospholipase A2 group IB Homo sapiens 68-84 3862730-4 1985 Peripheral blood PMN from patients with RA (RA-PMN) exhibit greater phospholipase A2 activities against phosphatidylcholine (PC) and phosphatidylethanolamine (PE), and greater phospholipase C activities against PC, PE, and phosphatidylinositol (PI) than PMN obtained from normal volunteers (N-PMN). phosphatidylethanolamine 159-161 phospholipase A2 group IB Homo sapiens 68-84 3931645-7 1985 Angiotensin II decreased the incorporation of [3H]arachidonate into phosphatidylcholine (PC) and phosphatidylethanolamine (PE). phosphatidylethanolamine 97-121 angiotensinogen Rattus norvegicus 0-14 3931645-7 1985 Angiotensin II decreased the incorporation of [3H]arachidonate into phosphatidylcholine (PC) and phosphatidylethanolamine (PE). phosphatidylethanolamine 123-125 angiotensinogen Rattus norvegicus 0-14 3931645-9 1985 Thus we assume that angiotensin II may induce a shift in phospholipid synthesis from PC and PE to phosphoinositides. phosphatidylethanolamine 92-94 angiotensinogen Rattus norvegicus 20-34 4052568-4 1985 P-31 CP spectra of all the phosphatidylcholines and phosphatidylethanolamine revealed a decrease in intensity in the vicinity of the isotropic chemical shift as long as the lipid was above the gel-to-liquid crystalline phase transition temperature. phosphatidylethanolamine 52-76 ATPase H+ transporting V1 subunit E1 Bos taurus 0-4 2413014-3 1985 Addition of phosphatidylethanolamine (PE) or phosphatidylserine to the reconstitution mixture restores high affinity LqTx binding with KD = 1.9 nM for PC/PE vesicles at -90 mV and 36 degrees C in sucrose-substituted medium. phosphatidylethanolamine 12-36 procollagen C-endopeptidase enhancer Rattus norvegicus 38-40 4069112-7 1985 Treatment with IFN resulted in an increased U/S ratio in cell surface PE (1.10) but not in other PE species (1.46). phosphatidylethanolamine 70-72 interferon alpha 1 Homo sapiens 15-18 4069112-7 1985 Treatment with IFN resulted in an increased U/S ratio in cell surface PE (1.10) but not in other PE species (1.46). phosphatidylethanolamine 97-99 interferon alpha 1 Homo sapiens 15-18 2996496-6 1985 Sphingomyelin [20% molar (20 mol of sphingomyelin/80 mol of phosphatidylethanolamine)] activates phosphatidylethanolamine hydrolysis by intestinal mucosal phospholipase A2, and then at higher concentrations (40% molar) substantially inhibits the activity. phosphatidylethanolamine 60-84 phospholipase A2 group IB Homo sapiens 155-171 2996496-6 1985 Sphingomyelin [20% molar (20 mol of sphingomyelin/80 mol of phosphatidylethanolamine)] activates phosphatidylethanolamine hydrolysis by intestinal mucosal phospholipase A2, and then at higher concentrations (40% molar) substantially inhibits the activity. phosphatidylethanolamine 97-121 phospholipase A2 group IB Homo sapiens 155-171 4026320-5 1985 First, after culture of hepatoma cells for 10 h, 88% of the nsLTP (as judged by its phosphatidylethanolamine transfer activity) appears in the medium, whereas the cytosolic level of transfer activity remains unchanged. phosphatidylethanolamine 84-108 sterol carrier protein 2 Homo sapiens 60-65 4063348-4 1985 For both types of sn-2 acyl chain, assuming a single-exponential correlation time and that the motion is within the rapid regime, the phosphatidylcholine lipid systems are less mobile than their phosphatidylethanolamine analogues. phosphatidylethanolamine 195-219 solute carrier family 38 member 5 Homo sapiens 18-22 4063348-6 1985 The rates of motion of the sn-2 acyl chains of phosphatidylethanolamine in a bilayer structure are slower than those of the lipid in an inverted hexagonal structure. phosphatidylethanolamine 47-71 solute carrier family 38 member 5 Homo sapiens 27-31 3931627-4 1985 On the other hand, MAF induced a slow liberation of arachidonic acid, mainly from phosphatidylethanolamine (PE) and phosphatidylcholine (PC) by phospholipase A2 after the incubation period of 30 min, but not any rapid changes in phospholipids. phosphatidylethanolamine 82-106 transcription factor Maf Cavia porcellus 19-22 3931627-4 1985 On the other hand, MAF induced a slow liberation of arachidonic acid, mainly from phosphatidylethanolamine (PE) and phosphatidylcholine (PC) by phospholipase A2 after the incubation period of 30 min, but not any rapid changes in phospholipids. phosphatidylethanolamine 108-110 transcription factor Maf Cavia porcellus 19-22 2982642-1 1985 Whereas the monomethylation of hippocampal phosphatidylethanolamine is decreased following the induction of long-lasting potentiation of the CA1 population spike, carboxymethylation of proteins is unaffected. phosphatidylethanolamine 43-67 carbonic anhydrase 1 Homo sapiens 141-144 2982398-7 1985 Among phospholipids with the same acyl moiety but different head groups, phosphatidylethanolamine was found to be more effective than phosphatidylcholine in protecting cytochrome c oxidase from thermodenaturation. phosphatidylethanolamine 73-97 cytochrome c, somatic Homo sapiens 168-180 4084264-1 1985 Cleavage of mitochondrial phosphatidylethanolamine (PE), phosphatidylcholine (PC) and cardiolipin (CL) by phospholipase A2 but not selective degradation of PE and PC by phospholipase C dissociates creatine kinase from rat heart mitochondria. phosphatidylethanolamine 26-50 phospholipase A2 group IB Rattus norvegicus 106-122 6517922-2 1984 The use of phosphatidylethanolamine labelled in the 2 position as substrate established that phospholipase A activity was 2 acyl-specific. phosphatidylethanolamine 11-35 phospholipase A and acyltransferase 1 Homo sapiens 93-108 6439250-9 1984 The acyltransferase activities with the lysoPE analogues were higher than the phospholipase A2 activities with PE analogues. phosphatidylethanolamine 44-46 phospholipase A2 group IB Rattus norvegicus 78-94 6509074-1 1984 Phospholipase A1, A2 and C activities with phosphatidylethanolamine were enhanced in C6 cells relative to primary astrocytic cultures. phosphatidylethanolamine 43-67 lipase H Homo sapiens 0-20 6517595-5 1984 Normal-phase HPLC analysis confirmed that both PC and PE in the liver phospholipids were peroxidized after CCl4 treatment. phosphatidylethanolamine 54-56 C-C motif chemokine ligand 4 Rattus norvegicus 107-111 6208335-6 1984 Admixing 10% of a partially degraded sample of bovine brain phosphatidylethanolamine also led to a large amount of aggregation induced by the myelin basic protein. phosphatidylethanolamine 60-84 myelin basic protein Bos taurus 142-162 6091780-5 1984 Thrombin caused loss of [14C]arachidonate-labelled phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol. phosphatidylethanolamine 72-96 coagulation factor II, thrombin Sus scrofa 0-8 6392853-8 1984 In addition to the identification of a new ino4-allele, further characterization of the existing series of ino4 and ino2 mutants, reported here, demonstrated that they all have a reduced capacity to convert phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 207-231 Ino4p Saccharomyces cerevisiae S288C 43-47 6392853-8 1984 In addition to the identification of a new ino4-allele, further characterization of the existing series of ino4 and ino2 mutants, reported here, demonstrated that they all have a reduced capacity to convert phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 207-231 Ino4p Saccharomyces cerevisiae S288C 107-111 6392853-8 1984 In addition to the identification of a new ino4-allele, further characterization of the existing series of ino4 and ino2 mutants, reported here, demonstrated that they all have a reduced capacity to convert phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 207-231 Ino2p Saccharomyces cerevisiae S288C 116-120 6486820-9 1984 When membrane-bound enzyme was measured with exogenous phosphatidylethanolamine, small stimulations by calmodulin were found. phosphatidylethanolamine 55-79 calmodulin 1 Rattus norvegicus 103-113 6437832-7 1984 Phosphatidylethanolamine and phosphatidylcholine were the most significant donors of AA during thrombin stimulation. phosphatidylethanolamine 0-24 coagulation factor II, thrombin Homo sapiens 95-103 6512166-5 1984 Sphingomyelin (Sph) and phospharidyl choline (PC) increased, while phosphatidyl ethanolamine (PE) decreased in the plasma membranes isolated from the CCl4-treated group. phosphatidylethanolamine 67-92 C-C motif chemokine ligand 4 Rattus norvegicus 150-154 6512166-5 1984 Sphingomyelin (Sph) and phospharidyl choline (PC) increased, while phosphatidyl ethanolamine (PE) decreased in the plasma membranes isolated from the CCl4-treated group. phosphatidylethanolamine 94-96 C-C motif chemokine ligand 4 Rattus norvegicus 150-154 6433504-2 1984 The addition of phospholipid vesicles containing phosphatidylserine and phosphatidylethanolamine to normal plasma and that of patients with von Willebrand"s disease resulted in the loss of almost two thirds of the factor VIII clotting antigen (VIII:CAg) measurable by IRMA. phosphatidylethanolamine 72-96 cytochrome c oxidase subunit 8A Homo sapiens 221-225 6433504-2 1984 The addition of phospholipid vesicles containing phosphatidylserine and phosphatidylethanolamine to normal plasma and that of patients with von Willebrand"s disease resulted in the loss of almost two thirds of the factor VIII clotting antigen (VIII:CAg) measurable by IRMA. phosphatidylethanolamine 72-96 cytochrome c oxidase subunit 8A Homo sapiens 244-248 6464031-4 1984 Incorporation of [1-14C]acetate into liver lipids, esterified cholesterol, triglycerides, free cholesterol and phosphatidyl ethanolamine was reduced in T-2 toxin-treated animals, implying reduced lipogenesis. phosphatidylethanolamine 111-136 brachyury 2 Rattus norvegicus 152-155 6373768-2 1984 Subsequent treatment with physiological concentrations of insulin provoked 40-70% increases in 32PO4 levels (reflecting increases in mass) in phosphatidic acid, phosphatidylinositol, and polyphosphoinositides, and, lesser, 20-25% increases in phosphatidylserine and the combined chromatographic area containing phosphatidylethanolamine plus phosphatidylcholine plus phosphatidylcholine. phosphatidylethanolamine 311-335 insulin Homo sapiens 58-65 6587389-1 1984 Spin-labeled analogs of phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine have been used to study phospholipid transverse diffusion and asymmetry in the human erythrocyte membrane. phosphatidylethanolamine 69-93 spindlin 1 Homo sapiens 0-4 6433893-2 1984 Studies with phospholipase A2 and sphingomyelinase C show that the asymmetric distribution of phosphatidylethanolamine (PtdEtn) in the membrane of these cells differs from that found in control cells. phosphatidylethanolamine 94-118 phospholipase A2 group IB Homo sapiens 13-29 6433893-2 1984 Studies with phospholipase A2 and sphingomyelinase C show that the asymmetric distribution of phosphatidylethanolamine (PtdEtn) in the membrane of these cells differs from that found in control cells. phosphatidylethanolamine 120-126 phospholipase A2 group IB Homo sapiens 13-29 6747460-1 1984 The rate of removal of phosphatidylethanolamine and phosphatidylcholine from the plasma of rats treated with antiserum to hepatic lipase was measured. phosphatidylethanolamine 23-47 lipase C, hepatic type Rattus norvegicus 122-136 6747460-9 1984 The data suggest that phosphatidylethanolamine is a preferred substrate for hepatic lipase in the metabolism of chylomicron and high density lipoprotein phospholipid. phosphatidylethanolamine 22-46 lipase C, hepatic type Rattus norvegicus 76-90 6715371-4 1984 259, 5734-5739) was applied to the activation of phospholipase A2-catalyzed hydrolysis of a thiol ester analog of phosphatidylethanolamine (thio - PE) in Triton X - 100/phospholipid mixed micelles by various phosphorylcholine-containing activators. phosphatidylethanolamine 114-138 phospholipase A2 group IB Homo sapiens 49-65 6704408-7 1984 A major part of the rapid phosphatidylethanolamine metabolism occurs in the liver, where the activity of the hepatic lipase is likely to be of crucial importance. phosphatidylethanolamine 26-50 lipase C, hepatic type Rattus norvegicus 109-123 6363386-10 1984 Whereas the head group phospholipid composition was the same between parental and mutant strains, strain-dependent changes in fatty acids were observed, most notably a 40% increase in the oleic acid content of phosphatidylethanolamine of one erg6 mutant, JR5. phosphatidylethanolamine 210-234 sterol 24-C-methyltransferase Saccharomyces cerevisiae S288C 242-246 6320878-0 1984 The influence of Ca2+ on the lateral lipid distribution and phase transition in phosphatidylethanolamine/phosphatidylserine vesicles. phosphatidylethanolamine 80-104 carbonic anhydrase 2 Homo sapiens 17-20 6361126-5 1984 These studies indicate that by using vesicles composed of 50% phosphatidylethanolamine/50% phosphatidylserine it is possible to introduce into the mouse EL4 cell surface about 70% of the amount of HLA expressed normally on the human lymphoblastoid line JY. phosphatidylethanolamine 62-86 epilepsy 4 Mus musculus 153-156 6316941-5 1983 Digestion of control liver membranes with exogenous phospholipase A2 decreased phosphatidylcholine and phosphatidylethanolamine levels by 50.6 and 51.2%, respectively, but increased lysophosphatidylcholine and lysophosphatidylethanolamine levels by 12- and 8.4-fold, respectively. phosphatidylethanolamine 103-127 phospholipase A2 group IB Canis lupus familiaris 52-68 6746018-2 1984 alpha-Mannose and beta-galactose were grafted on the surface of liposomes containing lysozyme by covalent coupling of p-aminophenyl-D-glycosides to phosphatidyl ethanolamine liposomes using glutaraldehyde. phosphatidylethanolamine 148-173 lysozyme Homo sapiens 85-93 6441310-9 1984 Phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol inhibited the phospholipase A2-induced platelet aggregation. phosphatidylethanolamine 21-45 phospholipase A2 Apis mellifera 85-101 6686250-2 1983 The dietary PE, but not PC, caused a decrease in serum cholesterol, phospholipid, apolipoprotein A-I (apoA-I) and apoE and an increase in high molecular weight apoB. phosphatidylethanolamine 12-14 apolipoprotein A1 Rattus norvegicus 82-100 6686250-2 1983 The dietary PE, but not PC, caused a decrease in serum cholesterol, phospholipid, apolipoprotein A-I (apoA-I) and apoE and an increase in high molecular weight apoB. phosphatidylethanolamine 12-14 apolipoprotein A1 Rattus norvegicus 102-108 6686250-2 1983 The dietary PE, but not PC, caused a decrease in serum cholesterol, phospholipid, apolipoprotein A-I (apoA-I) and apoE and an increase in high molecular weight apoB. phosphatidylethanolamine 12-14 apolipoprotein E Rattus norvegicus 114-118 6715338-2 1984 This phospholipase A1 activity was relatively specific for phosphatidic acid; the addition of several other phospholipids in equimolar amounts did not have a significant effect on the hydrolysis of radiolabeled phosphatidic acid, and the specific activity for phosphatidic acid hydrolysis was 20-fold higher than that of the hydrolysis of phosphatidylcholine, phosphatidylethanolamine, or phosphatidylinositol under the conditions used. phosphatidylethanolamine 360-384 lipase H Homo sapiens 5-21 6885797-10 1983 The apparent Km for AdoMet at pH 10.25 for the conversion of PE to PME was 58 microM, PME to PDE was 65 microM, and PDE to PC was 96 microM. phosphatidylethanolamine 61-63 methionine adenosyltransferase 1A Rattus norvegicus 20-26 6680524-1 1983 The catalysis by phosphatidylethanolamine methyltransferase (PEMT) of phosphatidylcholine (PC) synthesis by the successive methylation of phosphatidylethanolamine in the presence of S-adenosylmethionine (AdoMet) as methyl donor, was detected in actively myelinating mouse brains. phosphatidylethanolamine 17-41 phosphatidylethanolamine N-methyltransferase Homo sapiens 61-65 6413658-1 1983 In brain, phosphatidylethanolamine can be synthesized from free ethanolamine either by a pathway involving the formation of CDP-ethanolamine and its transfer to diglyceride, or by base-exchange of ethanolamine with existing phospholipids. phosphatidylethanolamine 10-34 cut-like homeobox 1 Rattus norvegicus 124-127 6644446-5 1983 Phosphatidylcholine and phosphatidylethanolamine were digested by phospholipase A2. phosphatidylethanolamine 24-48 phospholipase A2 group IB Homo sapiens 66-82 6137423-12 1983 Gastrin significantly increased the incorporation of [14C]-glycerol-3-phosphate into phosphatidylethanolamine in the presence of acetylcholine (Ach). phosphatidylethanolamine 85-109 gastrin Canis lupus familiaris 0-7 6615923-1 1983 Superoxide dismutase from erythrocytes and ceruloplasmin of serum inhibit the oxidation of phosphatidylcholine and phosphatidylethanolamine solubilized by cholate. phosphatidylethanolamine 115-139 ceruloplasmin Homo sapiens 43-56 6137423-14 1983 In the experiments with [32P]-labeled phospholipids, gastrin increased the incorporation of [32P] into phosphatidylethanolamine significantly. phosphatidylethanolamine 103-127 gastrin Canis lupus familiaris 53-60 6137423-15 1983 The significant increase of the radioactivity in phosphatidylinositol by Ach failed to be enhanced by gastrin, but that of phosphatidylethanolamine by Ach was enhanced by gastrin. phosphatidylethanolamine 123-147 gastrin Canis lupus familiaris 171-178 6303406-6 1983 Order parameter values of spin labels in liposomes containing brain phosphatidylcholine and phosphatidylethanolamine increased in parallel with increases in plasmenylethanolamine concentrations, indicating that fluidity was decreasing. phosphatidylethanolamine 92-116 spindlin 1 Rattus norvegicus 26-30 6838561-2 1983 Phosphatidic acid, phosphatidyl ethanolamine, phosphatidyl serine, phosphatidyl inositol, phosphatidyl glycerol and cardiolipin were found to activate greatly the cathepsin D. phosphatidylethanolamine 19-44 cathepsin D Homo sapiens 163-174 6337128-1 1983 The Saccharomyces cerevisiae opi3-3 mutant was shown to be defective in the synthesis of phosphatidylcholine via methylation of phosphatidylethanolamine. phosphatidylethanolamine 128-152 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 29-35 6841360-4 1983 The purified phospholipase A2 preferentially hydrolyzed phosphatidylethanolamine, especially if it contained linoleic acid. phosphatidylethanolamine 56-80 phospholipase A2 group IB Rattus norvegicus 13-29 6297895-1 1983 Interactions of band 4.1 with mixed phospholipid membranes [phosphatidylserine (PtdSer), phosphatidylethanolamine, phosphatidylcholine, etc.] phosphatidylethanolamine 89-113 erythrocyte membrane protein band 4.1 Homo sapiens 16-24 6860684-0 1983 Transfer of cholesteryl linoleyl ether from phosphatidylcholine and phosphatidylethanolamine liposomes to cultured cells catalyzed by lipoprotein lipase. phosphatidylethanolamine 68-92 lipoprotein lipase Homo sapiens 134-152 6838506-0 1983 Ca2+ and pH induced fusion of small unilamellar vesicles consisting of phosphatidylethanolamine and negatively charged phospholipids: a freeze fracture study. phosphatidylethanolamine 71-95 carbonic anhydrase 2 Homo sapiens 0-3 6298074-4 1983 Sphingomyelin, phosphatidylcholine and phosphatidylethanolamine were removed by phospholipase C (C. welchii and B. cereus) treatment. phosphatidylethanolamine 39-63 LOC100009319 Oryctolagus cuniculus 80-95 7171594-1 1982 Glycophorin A, the major sialoglycoprotein of the human erythrocyte membrane, has been incorporated in small unilamellar vesicles containing phosphatidylcholine and phosphatidylethanolamine in varying proportions. phosphatidylethanolamine 165-189 glycophorin A (MNS blood group) Homo sapiens 0-13 6214785-3 1982 Synexin facilitated Ca2+-mediated, but not Mg2+-mediated, fusion of phosphatidate/phosphatidylethanolamine (1:3) and phosphatidate/phosphatidylserine/phosphatidylethanolamine/cholesterol (1:2:3:2) vesicles. phosphatidylethanolamine 82-106 annexin A7 Homo sapiens 0-7 6214785-3 1982 Synexin facilitated Ca2+-mediated, but not Mg2+-mediated, fusion of phosphatidate/phosphatidylethanolamine (1:3) and phosphatidate/phosphatidylserine/phosphatidylethanolamine/cholesterol (1:2:3:2) vesicles. phosphatidylethanolamine 150-174 annexin A7 Homo sapiens 0-7 6810947-8 1982 Deoxycholate also induces slightly the disappearance of some 14C radioactivity from phosphatidylethanolamine and phosphatidylcholine, which might reflect activation of phospholipase A2. phosphatidylethanolamine 84-108 phospholipase A2 group IB Rattus norvegicus 168-184 7139957-1 1982 Phospholipase A activity was determined in human plasma with biological 32P-labelled phosphatidylethanolamine from rat liver following cardiac operations with the aid of the heart-lung-machine. phosphatidylethanolamine 85-109 phospholipase A and acyltransferase 1 Homo sapiens 0-15 7142127-4 1982 This P-450 fraction catalyzed myristate omega- and (omega-1)-hydroxylation with a turnover rate of 5.0 nmol/nmol of cytochrome P-450 in a reconstituted system containing NADPH-cytochrome c reductase, cytochrome b5 and phosphatidylethanolamine. phosphatidylethanolamine 218-242 cytochrome P-450 Oryctolagus cuniculus 116-132 7127187-7 1982 The CDP-ethanolamine pathway was estimated to contribute 290 nmol x min-1 x g heart-1 to total phosphatidylethanolamine formation in hamster heart. phosphatidylethanolamine 95-119 cut like homeobox 1 Homo sapiens 4-7 7127187-10 1982 Hence, it was concluded that phosphatidylethanolamine was synthesized by all three known pathways and the CDP-ethanolamine pathway was the major pathway for phosphatidylethanolamine biosynthesis in the mammalian heart. phosphatidylethanolamine 157-181 cut like homeobox 1 Homo sapiens 106-109 6806255-1 1982 Mouse peritoneal macrophages have a phospholipase A2 activity which is optimally active at pH 8.5 (PLA8.5), requires 2 mM Ca2+ and is capable of hydrolyzing arachidonic acid from phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 203-227 phospholipase A2, group IB, pancreas Mus musculus 36-52 7076675-0 1982 Inhibition of phosphatidylethanolamine N-methylation by 3-deazaadenosine stimulates the synthesis of phosphatidylcholine via the CDP-choline pathway. phosphatidylethanolamine 14-38 cut like homeobox 1 Homo sapiens 129-132 7289798-6 1981 Phospholipase A2 action on phosphatidylcholine and phosphatidylethanolamine demonstrated enrichment of the c,c- and the c,t-18:2 products in the 2-position, whereas the 18:1 substrates were preferentially inserted into the 1-positions. phosphatidylethanolamine 51-75 phospholipase A2 group IB Rattus norvegicus 0-16 7104293-4 1982 The phosphatidylethanolamine distribution, determined by chemical labeling with trinitrobenzenesulfonic acid, was assessed in vesicles the contained intact cytochrome b5 molecules and in vesicles where only the hydrophobic tail remained associated with the bilayer. phosphatidylethanolamine 4-28 cytochrome b5 type A Homo sapiens 156-169 7136004-10 1982 Alterations in hepatic drug metabolism are possibly mediated via changes in microsomal phospholipids and/or the cytochrome P-450 spin-state equilibrium as as pregnancy was associated with a decrease in (a) microsomal total phospholipids, (b) the phosphatidylcholine to phosphatidylethanolamine ratio and (c) the high-spin form of ferricytochrome P-450. phosphatidylethanolamine 269-293 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 112-128 7093256-6 1982 On longer incubation, up to 30 min, with CDP[14 C]ethanolamine the specific activity of the outer leaflet phosphatidylethanolamine becomes close to that of the inner leaflet. phosphatidylethanolamine 106-130 cut-like homeobox 1 Rattus norvegicus 41-44 7093256-7 1982 In chase experiments, in which microsomal phosphatidylethanolamine was labelled by incubation with CDP[14 C]ethanolamine for 1 min, the reaction stopped by addition of calcium, and the microsomes isolated by centrifugation and reincubated, labelled phosphatidylethanolamine was transferred from the "outer leaflet" to the "inner leaflet", so that both were equally labelled. phosphatidylethanolamine 42-66 cut-like homeobox 1 Rattus norvegicus 99-102 6282591-0 1982 Spin-label characterisation of the lamellar-to-hexagonal (HII) phase transition in egg phosphatidylethanolamine aqueous dispersions. phosphatidylethanolamine 87-111 spindlin 1 Homo sapiens 0-4 6282591-1 1982 The thermotropic behaviour of egg yolk phosphatidylethanolamine dispersions in excess aqueous phase has been investigated by spin label electron spin resonance spectroscopy and differential thermal analysis. phosphatidylethanolamine 39-63 spindlin 1 Homo sapiens 125-129 6282591-1 1982 The thermotropic behaviour of egg yolk phosphatidylethanolamine dispersions in excess aqueous phase has been investigated by spin label electron spin resonance spectroscopy and differential thermal analysis. phosphatidylethanolamine 39-63 spindlin 1 Homo sapiens 145-149 6282591-2 1982 Phosphatidylethanolamine isomers spin-labelled at six different positions along the acyl chain, and steroid spin labels, indicate both gel-fluid lamellar and lamellar-reverse hexagonal (HII) phase transitions, in agreement with complementary calorimetric studies. phosphatidylethanolamine 0-24 spindlin 1 Homo sapiens 33-37 6282591-5 1982 The phosphatidylethanolamine spin labels also indicate a polarity profile which is characteristic of each phase. phosphatidylethanolamine 4-28 spindlin 1 Homo sapiens 29-33 7087686-3 1982 In the second series of experiments, the purified phospholipase A2 showed preferential action toward PI (100%) compared to phosphatidylcholine (PC, 62.5%), phosphatidic acid (PA, 32.6%), phosphatidylethanolamine (PE, 25.1%) and phosphatidylserine (PS, 21.5%), where each phosphoglyceride was labeled in the 2-position with [1-14C] oleic acid. phosphatidylethanolamine 187-211 LOC104974671 Bos taurus 50-66 7087686-3 1982 In the second series of experiments, the purified phospholipase A2 showed preferential action toward PI (100%) compared to phosphatidylcholine (PC, 62.5%), phosphatidic acid (PA, 32.6%), phosphatidylethanolamine (PE, 25.1%) and phosphatidylserine (PS, 21.5%), where each phosphoglyceride was labeled in the 2-position with [1-14C] oleic acid. phosphatidylethanolamine 213-215 LOC104974671 Bos taurus 50-66 6459801-3 1982 Subsequent control experiments indicated that the resulting phosphatidylethanolamine was responsible for the lowered ATPase specific activity. phosphatidylethanolamine 60-84 dynein axonemal heavy chain 8 Homo sapiens 117-123 6188759-1 1982 The effect of human interferon (IFN) preparations on the metabolic pathway leading to the synthesis of phosphatidylcholine (PC) by a stepwise addition of methyl groups to phosphatidylethanolamine (PE) was investigated in human peripheral blood mononuclear (PBMN) cells. phosphatidylethanolamine 171-195 interferon alpha 1 Homo sapiens 20-36 6123164-6 1982 Both phosphatidylethanolamine and phosphatidylserine protected Na+-K+-ATPase from the inhibitory action of phospholipase A2 but not that of beta-bungarotoxin. phosphatidylethanolamine 5-29 phospholipase A2 group IB Rattus norvegicus 107-123 6273120-2 1981 During incubation of adrenal sections or cells in vitro, ACTH and cAMP increased the concentrations of and incorporation of [3H]glycerol and [14C]palmitate into phosphatidylcholine and phosphatidylethanolamine, two major phospholipids which are derived from phosphatidic acid, but are extrinsic to the inositide pathway. phosphatidylethanolamine 185-209 proopiomelanocortin Homo sapiens 57-61 6273120-4 1981 Similar to previously reported effects on phosphatidic acid and inositide phospholipids, cycloheximide blocked the effects of ACTH and cAMP on phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 167-191 proopiomelanocortin Homo sapiens 126-130 7309711-2 1981 Fatty acid omega- and (omega-1)-hydroxylation activity was reconstituted from the partially purified cytochrome P-450 and NADPH-cytochrome c reductase, with phosphatidylethanolamine or phosphatidylcholine. phosphatidylethanolamine 157-181 cytochrome P-450 Oryctolagus cuniculus 101-117 6452452-5 1981 Synexin lowers the threshold of CA2+ concentration required for fusion of large unilamellar vesicles of phosphatidylserine and a mixture of phosphatidylserine with phosphatidylethanolamine. phosphatidylethanolamine 164-188 annexin A7 Homo sapiens 0-7 7264659-3 1981 In Trembler cells, cultivated in the presence of labelled acetate, the fatty acids were slightly altered; phosphatidylcholine was slightly reduced and phosphatidylethanolamine increased. phosphatidylethanolamine 151-175 peripheral myelin protein 22 Mus musculus 3-11 6973491-0 1981 CoA-dependent cleavage of arachidonic acid from phosphatidylcholine and transfer to phosphatidylethanolamine in homogenates of murine thymocytes. phosphatidylethanolamine 84-108 HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Mus musculus 0-3 6452452-5 1981 Synexin lowers the threshold of CA2+ concentration required for fusion of large unilamellar vesicles of phosphatidylserine and a mixture of phosphatidylserine with phosphatidylethanolamine. phosphatidylethanolamine 164-188 carbonic anhydrase 2 Homo sapiens 32-35 7225377-7 1981 Phosphatidylethanolamine also facilitated fusion by Mg2+ which could not fuse pure phosphatidylserine vesicles. phosphatidylethanolamine 0-24 mucin 7, secreted Homo sapiens 52-55 7219528-3 1981 Recently we and others have demonstrated that various preparations of mammalian brain contain enzymes, the phosphatidylethanolamine N-methyltransferase (PeMT), which catalyse the synthesis of phosphatidylcholine (PC), using S-adenosylmethionine (SAM) as a methyl donor for the stepwise methylation of phosphatidylethanolamine (PE). phosphatidylethanolamine 107-131 phosphatidylethanolamine N-methyltransferase Homo sapiens 153-157 7219528-3 1981 Recently we and others have demonstrated that various preparations of mammalian brain contain enzymes, the phosphatidylethanolamine N-methyltransferase (PeMT), which catalyse the synthesis of phosphatidylcholine (PC), using S-adenosylmethionine (SAM) as a methyl donor for the stepwise methylation of phosphatidylethanolamine (PE). phosphatidylethanolamine 327-329 phosphatidylethanolamine N-methyltransferase Homo sapiens 107-151 7219528-3 1981 Recently we and others have demonstrated that various preparations of mammalian brain contain enzymes, the phosphatidylethanolamine N-methyltransferase (PeMT), which catalyse the synthesis of phosphatidylcholine (PC), using S-adenosylmethionine (SAM) as a methyl donor for the stepwise methylation of phosphatidylethanolamine (PE). phosphatidylethanolamine 327-329 phosphatidylethanolamine N-methyltransferase Homo sapiens 153-157 7225377-11 1981 Mg2+ had a synergistic effect on Ca2+-induced fusion of phosphatidylserine/phosphatidylethanolamine vesicles. phosphatidylethanolamine 75-99 mucin 7, secreted Homo sapiens 0-3 7462211-4 1981 Decreases in phosphatidylcholine and also phosphatidylethanolamine occur within 20 s after stimulation of platelets by thrombin. phosphatidylethanolamine 42-66 coagulation factor II, thrombin Homo sapiens 119-127 6257695-4 1981 Thermal transitions were detected in Arrhenius plots of 5"-nucleotidase after detergent solubilization, in the membranes which contained the three phospholipids, but not in the purified fraction which contained only sphingomyelin; transitions were also detected after reassociation of the purified enzyme with microsomal or plasma membrane lipids and phosphatidylcholine but not with phosphatidylethanolamine. phosphatidylethanolamine 384-408 5' nucleotidase, ecto Rattus norvegicus 56-71 7462211-6 1981 The concomitant increases in lysophosphatidylcholine and decreases in phosphatidylcholine, as well as the decreases in phosphatidylethanolamine, can only be explained by the stimulation of phospholipase A2 activity in platelets by thrombin. phosphatidylethanolamine 119-143 phospholipase A2 group IB Homo sapiens 189-205 6174024-4 1981 A soluble ATPase extract having low phospholipid content was found to be activated by the phospholipid extracts of Vibrio el tor, phosphatidyl ethanolamine, and also by phosphatidyl choline which is not a constituent of the membrane preparation of Vibrio el tor strains. phosphatidylethanolamine 130-155 dynein axonemal heavy chain 8 Homo sapiens 10-16 7219664-4 1981 There was a tendency by the neuronal phospholipase A2 to release arachidonic acid faster than linolenic acid from both phosphatidylcholine and -ethanolamine, while arachidonic acid was removed less actively from phosphatidylethanolamine by the glial enzyme. phosphatidylethanolamine 212-236 phospholipase A2 Oryctolagus cuniculus 37-53 6783529-7 1980 Both the inner and outer leaflets of the erythrocyte membrane were accessible to this rickettsial phospholipase A activity since both phosphatidylcholine and phosphatidylethanolamine were substrates in human erythrocytes. phosphatidylethanolamine 158-182 phospholipase A and acyltransferase 1 Homo sapiens 98-113 7430120-9 1980 Deoxycholate treatment of the particulate fractions results in cleavage by phospholipase A2 of phosphatidylcholine and phosphatidylethanolamine but not of phosphatidylinositol. phosphatidylethanolamine 119-143 phospholipase A2 Equus caballus 75-91 7430120-10 1980 The preferred substrates for platelet phospholipase A2 appear to be phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine, while phosphatidylinositol seems to be degraded nearly exclusively by phospholipase C. phosphatidylethanolamine 68-92 phospholipase A2 Equus caballus 38-54 7391568-1 1980 The plasma membrane Fc receptor for IgG2b on P388D1 cells, solubilized by detergent, was inactivated by incubation with phospholipase C. Soluble Fc receptor activity could be restored by the addition of liposomes of either phosphatidylethanolamine or phosphatidylinositol. phosphatidylethanolamine 223-247 Fc receptor Mus musculus 20-31 7391568-1 1980 The plasma membrane Fc receptor for IgG2b on P388D1 cells, solubilized by detergent, was inactivated by incubation with phospholipase C. Soluble Fc receptor activity could be restored by the addition of liposomes of either phosphatidylethanolamine or phosphatidylinositol. phosphatidylethanolamine 223-247 immunoglobulin heavy constant gamma 2B Mus musculus 36-41 7391568-1 1980 The plasma membrane Fc receptor for IgG2b on P388D1 cells, solubilized by detergent, was inactivated by incubation with phospholipase C. Soluble Fc receptor activity could be restored by the addition of liposomes of either phosphatidylethanolamine or phosphatidylinositol. phosphatidylethanolamine 223-247 Fc receptor Mus musculus 145-156 6249579-10 1980 Treatment of microsomes with phospholipase C and toluene-2,4-diisocyanate resulted in an apparent loss of about 65% and 85% of the original glucose-6-phosphatase activity and was closely correlated with hydrolysis and chemical modification of phosphatidylethanolamine, respectively. phosphatidylethanolamine 243-267 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 140-161 7412509-5 1980 These results demonstrate the in vitro susceptibility of phospholipids of myocardial membranes, particularly phosphatidylethanolamine, to the neutral-active, Ca2+-dependent phospholipase A2 from granulocytes. phosphatidylethanolamine 109-133 phospholipase A2 group V Homo sapiens 142-189 7314059-3 1981 TLC analysis revealed that the stimulation of the decrease in radioactivity of phospholipids was almost exclusively attributed to that of phosphatidylcholine (PC), and that thrombin induced a slight but significant increase in radioactivity of phosphatidylethanolamine (PE) in the reserpinized platelets. phosphatidylethanolamine 244-268 prothrombin Oryctolagus cuniculus 173-181 7314059-3 1981 TLC analysis revealed that the stimulation of the decrease in radioactivity of phospholipids was almost exclusively attributed to that of phosphatidylcholine (PC), and that thrombin induced a slight but significant increase in radioactivity of phosphatidylethanolamine (PE) in the reserpinized platelets. phosphatidylethanolamine 270-272 prothrombin Oryctolagus cuniculus 173-181 7314059-5 1981 Thrombin-induced mobilization of PC to PE in the reserpinized platelet phospholipids was also suggested. phosphatidylethanolamine 39-41 prothrombin Oryctolagus cuniculus 0-8 7364757-5 1980 On the other hand, SPF was shown to bind tightly to vesicles of anionic phospholipids (phosphatidylglycerol, phosphatidylserine, phosphatidylinositol, and phosphatidic acid) but not to vesicles of phosphatidylcholine or phosphatidylethanolamine. phosphatidylethanolamine 220-244 SEC14 like lipid binding 2 Homo sapiens 19-22 227881-7 1979 Emulgen 913, Tween 20, ethylene glycol, myristoyllysophosphatidylcholine, dimyristoylphosphatidylcholine, and phosphatidylethanolamine show the enhanced activity of cholesterol side chain cleavage reaction with cytochrome P-450scc, adrenodoxin, adrenodoxin reductase, and NADPH. phosphatidylethanolamine 110-134 cholesterol side-chain cleavage enzyme, mitochondrial Bos taurus 211-230 500676-5 1979 Phospholipid, specifically phosphatidylglycerol or phosphatidylethanolamine, is required for maximal stimulation of the cyclase by purified SPF. phosphatidylethanolamine 51-75 SEC14 like lipid binding 2 Homo sapiens 140-143 227881-7 1979 Emulgen 913, Tween 20, ethylene glycol, myristoyllysophosphatidylcholine, dimyristoylphosphatidylcholine, and phosphatidylethanolamine show the enhanced activity of cholesterol side chain cleavage reaction with cytochrome P-450scc, adrenodoxin, adrenodoxin reductase, and NADPH. phosphatidylethanolamine 110-134 ferredoxin reductase Bos taurus 245-266 227688-5 1979 The results are explained by assuming that the transport unit and the catalytic moiety of the glucose-6-phosphatase system have different lipid requirements, the activity of the former protein depending mainly on phosphatidylethanolamine and phosphatidylserine and that of the catalytic protein depending on phosphatidylcholine. phosphatidylethanolamine 213-237 glucose-6-phosphatase catalytic subunit 1 Rattus norvegicus 94-115 420827-3 1979 One enzyme with phospholipase A2 specificity was found to be responsible for both phosphatidyl-ethanolamine and phosphatidylcholine degradation. phosphatidylethanolamine 82-107 phospholipase A2 Ovis aries 16-32 226641-5 1979 The major changes in the acyl chain pattern SV3T3 compared with whole 3T3 cells consisted of an increase of oleic and palmitoleic acids coupled with a decrease of C20 and C22 polyunsaturated acids in phosphatidylethanolamine and phosphatidylcholine; an increase of oleic acid was also evident in SV3T3 phosphatidylinositol plus phosphatidylserine. phosphatidylethanolamine 200-224 Sp7 transcription factor 7 Mus musculus 171-174 223675-3 1979 It was demonstrated that the glucose-6-phosphate phosphohydrolase activity of glucose-6-phosphatase depends on the content of phosphatidylethanolamine in the microsomal membranes, whereas the inorganic pyrophosphate phosphohydrolase activity seems to be dependent on the phosphatidylserine content. phosphatidylethanolamine 126-150 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 78-99 738993-2 1978 Phospholipase A1 in FL cell cytosol showed activity only in the presence of a non-ionic detergent, Triton X-100, or certain phospholipids such as phosphatidylinositol, cardiolipin, phosphatidylserine, phosphatidic acid, phosphatidylethanolamine, and lysophosphatidylcholine, among which phosphatidylinositol was the most active stimulator of the activity. phosphatidylethanolamine 221-245 lipase H Homo sapiens 0-16 701283-1 1978 A new, rapid, and sensitive assay for phospholipase A, utilizing commercially available [14C]phosphatidylethanolamine with 14C label in both palmitic acid moieties, was used to study phospholipase A release from perfused liver, hepatocytes, and intestinal cells from rats. phosphatidylethanolamine 93-117 phospholipase A and acyltransferase 1 Rattus norvegicus 38-53 360047-2 1978 Sphingomyelin, phosphatidylserine, bovine lecithin and phosphatidylethanolamine modify the thermal stabilization of H2B-DNA complexes, by inducing stabilization at 0.3 and 0.6 H2B : DNA weight ratios and destabilify the arrangement of nucleohistone is confirmed by ultrastructural analysis which indicates a competitive action of these molecules during the nucleoprotein assembly. phosphatidylethanolamine 55-79 histone H2B type 2-E Bos taurus 116-119 360047-2 1978 Sphingomyelin, phosphatidylserine, bovine lecithin and phosphatidylethanolamine modify the thermal stabilization of H2B-DNA complexes, by inducing stabilization at 0.3 and 0.6 H2B : DNA weight ratios and destabilify the arrangement of nucleohistone is confirmed by ultrastructural analysis which indicates a competitive action of these molecules during the nucleoprotein assembly. phosphatidylethanolamine 55-79 histone H2B type 2-E Bos taurus 176-179 210832-4 1978 Using phosphatidyl-ethanolamine-coated triglyceride particles as substrate it was found that the phospholipase A1 and triglyceridase activities of lipoprotein lipase similarly depend on the presence of apolipoprotein C-II. phosphatidylethanolamine 6-31 lipoprotein lipase Rattus norvegicus 147-165 656394-4 1978 In most cases the previously inactive phospholipase A2 (EC 3.1.1.4, phosphatide-2-acyl-hydrolase) begins rapid hydrolysis of membrane phosphatidylethanolamine as ATP levels approach zero. phosphatidylethanolamine 134-158 phospholipase A2 group IB Homo sapiens 38-54 147706-13 1978 Hydrolysis of 95% of the phosphatidylcholine and 60--70% of the spingomyelin and phosphatidylethanolamine by another phospholipase C (Clostridium welchii) lowers the (Na+ + K+)-ATPase activity by about 20%. phosphatidylethanolamine 81-105 LOC100009319 Oryctolagus cuniculus 117-132 629287-4 1978 Phosphatidylethanolamine was found to be hydrolyzed more rapidly than was phosphatidycholine by the phospholipase A activities of human fetal membranes and uterine decidua and of rat liver mitochondria. phosphatidylethanolamine 0-24 phospholipase A and acyltransferase 1 Homo sapiens 100-115 665365-3 1978 Insulin enhances these activities within phosphatidylethanolamine. phosphatidylethanolamine 41-65 insulin Homo sapiens 0-7 566026-3 1978 In 12 healthy fertile and 20 subfertile individuals, the total phospholipase A2 activity toward radioactively labeled phosphatidylethanolamine has been compared with the total amounts of prostaglandins E and F, which have been determined by specific radioimmunoassay. phosphatidylethanolamine 118-142 phospholipase A2 group IB Homo sapiens 63-79 11946985-3 1969 While phospholipase A activity is much lower in the inner membrane than in the outer membrane of mitochondria the reverse is true for the incorporation of (14C)-oleic acid into endogenous phosphatidylethanolamine. phosphatidylethanolamine 188-212 phospholipase A and acyltransferase 1 Rattus norvegicus 6-21 38406-4 1979 The binding of SP to phosphatidyl serine, phosphatidyl ethanolamine and phosphatidyl inositol was lowest at pH 2 and increased with pH. phosphatidylethanolamine 42-67 tachykinin precursor 1 Homo sapiens 15-17 38406-9 1979 The high affinity (KD = 0.1 microM) and capacity of 44 pmol SP/microgram phosphatidyl serine and 48 pmol SP/microgram phosphatidyl ethanolamine at pH 7.2 under conditions of saturation contrasted with the very low binding of SP to phosphatidyl inositol or phosphatidyl choline. phosphatidylethanolamine 118-143 tachykinin precursor 1 Homo sapiens 105-107 38406-9 1979 The high affinity (KD = 0.1 microM) and capacity of 44 pmol SP/microgram phosphatidyl serine and 48 pmol SP/microgram phosphatidyl ethanolamine at pH 7.2 under conditions of saturation contrasted with the very low binding of SP to phosphatidyl inositol or phosphatidyl choline. phosphatidylethanolamine 118-143 tachykinin precursor 1 Homo sapiens 105-107 38406-12 1979 There was a concentration-dependent reduction in the binding of SP to phosphatidyl serine or phosphatidyl ethanolamine by Na+ and Ca2+, whereas K+ showed hardly any effect at physiological concentrations. phosphatidylethanolamine 93-118 tachykinin precursor 1 Homo sapiens 64-66 11215-8 1976 It was revealed that the usage of mitochondrial phospholipids and phosphatidylethanolamine allows the highest values of membrane potential to be obtained in the case of ATPase proteoliposomes. phosphatidylethanolamine 66-90 dynein axonemal heavy chain 8 Homo sapiens 169-175 1276220-1 1976 After incubation of human erythrocytes at 37 degrees C in the absence of glucose (A) for 24 h, (B) for 4 h with 8 mM hexanol or (C) for 3 h with SH reagents, phosphatidylethanolamine becomes partly susceptible to hydrolysis by phospholipase A2 from Naja naja. phosphatidylethanolamine 158-182 phospholipase A2 group IB Homo sapiens 227-243 1276220-4 1976 Pancreatic phospholipase A2, an enzyme unable to hydrolyse the phospholipids of intact erythrocytes, partially degrades phosphatidylcholine and phosphatidylethanolamine of erythrocytes pretreated with hexanol or SH reagents. phosphatidylethanolamine 144-168 phospholipase A2 group IB Homo sapiens 11-27 1009570-3 1976 The results with erythrocyte ghosts show that at 50 muM probe 31-50% of the total phosphatidylethanolamine is cross-linked to itself and 10-12% of the phosphatidylethanolamine is cross-linked to phosphatidylserine. phosphatidylethanolamine 82-106 latexin Homo sapiens 52-55 241749-2 1975 Ethanolaminephosphate cytidylyltransferase (EC 2.7.7.14), which catalyzes a central step in phosphatidylethanolamine synthesis, has been purified 1000-fold from a postmicrosomal supernatant from rat liver. phosphatidylethanolamine 92-116 phosphate cytidylyltransferase 2, ethanolamine Rattus norvegicus 0-42 1123345-5 1975 The rate of phosphatidylcholine synthesis via the CDP-ester pathway responded in a way analogous to that of phosphatidylethanolamine synthesis upon the addition of choline and fatty acid, except that a 10- to 20-fold higher concentration of choline was required for maximal stimulation, probably due to the rapid oxidation of choline to betaine. phosphatidylethanolamine 108-132 cut-like homeobox 1 Rattus norvegicus 50-53 5061920-3 1972 The PB-factor preparation and the heat-treated pancreatic lipase fraction catalyzed partial (15 to 50%) deacylation of diphosphatidylglycerol, phosphatidylglycerol, and phosphatidylethanolamine in disrupted spheroplasts but not in intact spheroplasts. phosphatidylethanolamine 169-193 pancreatic lipase Sus scrofa 47-64 5158903-11 1971 Insulin decreased the [(14)C]glucose solubilized by phosphatidylcholine, phosphatidylethanolamine and phosphatidic acid, but not by sphingomyelin. phosphatidylethanolamine 73-97 insulin Homo sapiens 0-7 5166856-0 1971 [Effect of phospholipase A from snake venom on phosphatidylcholine, phosphatidylethanolamine and on the corresponding plasmalogens. phosphatidylethanolamine 68-92 phospholipase A and acyltransferase 1 Homo sapiens 11-26 5461619-2 1970 Measurements have been made of the interaction of cytochrome c, bovine serum albumin and synthetic oxytocin with low-pressure (2dyn/cm) monolayers of stearic acid, phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 188-212 cytochrome c, somatic Homo sapiens 50-62 598786-1 1977 The incorporation of 32P-orthophosphate into phosphatidylethanolamine and phosphatidylcholine in vas deferens was increased by incubation with cocaine and denervation enhanced the action of cocaine on phospholipid metabolism in vas deferens. phosphatidylethanolamine 45-69 arginine vasopressin Rattus norvegicus 97-100 891851-0 1977 Biosynthesis of phosphatidylethanolamine from CDP-ethanolamine by the Golgi complex of rat liver in vitro. phosphatidylethanolamine 16-40 cut-like homeobox 1 Rattus norvegicus 46-49 851545-6 1977 From the positional distribution of 14C-labeled fatty acid and the change in the doubly labeled molecular species of phospholipids, it was concluded that tb degradation of dilinoleoylglycerophosphocholine and that of phosphatidylethanolamine could be accounted for by the action of phospholipase A1, while the degradation of dipalmitoylglycerophosphocholine proceeded through the action of phospholipase A2. phosphatidylethanolamine 217-241 phospholipase A2 group IB Rattus norvegicus 390-406 190241-6 1977 Phospholipase A treatment of intact microsomes in the presence of albumin hydrolyzed all of the phosphatidylethanolamine, phosphatidylserine, and 55% of the phosphatidylcholine. phosphatidylethanolamine 96-120 phospholipase A and acyltransferase 1 Homo sapiens 0-15 187172-4 1976 Analysis of the myelin pellet obtained after centrifugation of the myelin sample incubated with snake venom or phospholipase A alone showed conversion of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine into their corresponding lyso compounds. phosphatidylethanolamine 175-199 phospholipase A and acyltransferase 1 Homo sapiens 111-126 952985-4 1976 Phospholipase A2 activity in human seminal plasma towards sonicated radioactively-labelled phosphatidylethanolamine was slightly stimulated a low and inhibited at high concentrations of all anaesthetic compounds employed. phosphatidylethanolamine 91-115 phospholipase A2 group IB Homo sapiens 0-16 184285-4 1976 The interaction between oxidized cytochrome c and these lipid membranes is primarily of electrostatic nature, and dependent on the presence of highly charged phospholipids, such as diphosphatidyl glycerol (cardiolipin) and phosphatidyl ethanolamine. phosphatidylethanolamine 223-248 cytochrome c, somatic Homo sapiens 33-45 1262468-8 1976 The incubation of platelets with thrombin (0.05 U/ml) for 5 min results in 16.2% increase of PE labeling during subsequent 30-min incubation with TNBS. phosphatidylethanolamine 93-95 coagulation factor II, thrombin Homo sapiens 33-41 1200052-4 1975 That the chorioamnionic enzyme is of the phospholipase A2 type was established by product identification following the incubation of the enzyme with either radioactive phosphatidylcholine or phosphatidylethanolamine. phosphatidylethanolamine 191-215 phospholipase A2 group IB Homo sapiens 41-57 50420-3 1975 On investigating the specific activity of the enzyme with various molecular species of phosphatidylcholine and -ethanolamine, labelled at the 1 position with different radioactive fatty acids, we found that the phospholipase A1 preferentially removed those fatty acids from the 1 position of phosphatidylcholines that have the fewest double bonds, while oleic and linoleic acid were released at almost similar rates from phosphatidylethanolamine. phosphatidylethanolamine 421-445 lipase H Homo sapiens 211-227 4450216-0 1974 Effect of pregnancy and insulin administration on fatty acid distribution in phosphatidylethanolamine of maternal and fetal liver and lung in the rabbit. phosphatidylethanolamine 77-101 insulin Oryctolagus cuniculus 24-31 4360711-2 1973 The addition of mitochondria to an incubation system containing the soluble and microsomal fractions of rat liver enhances severalfold the incorporation of each of ethanolamine, phosphorylethanolamine and CDP-ethanolamine into phosphatidylethanolamine. phosphatidylethanolamine 227-251 cut-like homeobox 1 Rattus norvegicus 205-208 14250502-2 1964 ISOLATION OF A PHOSPHATIDYLETHANOLAMINE REQUIRED FOR LIPID-CYTOCHROME C FORMATION. phosphatidylethanolamine 15-39 cytochrome c, somatic Homo sapiens 59-71 33713833-4 2021 The mitochondrial lipidome reveals beta3-adrenergic stimulation and aging drastically altered the levels of phosphatidylcholine (PC)/phosphatidylethanolamine (PE) ratio and acyl chain desaturation. phosphatidylethanolamine 133-157 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 35-40 33713833-4 2021 The mitochondrial lipidome reveals beta3-adrenergic stimulation and aging drastically altered the levels of phosphatidylcholine (PC)/phosphatidylethanolamine (PE) ratio and acyl chain desaturation. phosphatidylethanolamine 159-161 cholinergic receptor, nicotinic, alpha polypeptide 3 Mus musculus 35-40 33909989-1 2021 Autophagy is a fundamental catabolic process that uses a unique post-translational modification, the conjugation of ATG8 protein to phosphatidylethanolamine (PE). phosphatidylethanolamine 132-156 GABA type A receptor associated protein like 1 Homo sapiens 116-120 33974957-9 2021 Genetic analysis using long-lived mutants and knockdown by RNAi revealed that the lifespan-extending effect of phosphatidylethanolamine overlapped with that of reduced insulin/IGF-1-like signaling and required DAF-16, a downstream transcription factor known to regulate the expression of many stress-responsive genes. phosphatidylethanolamine 111-135 Fork-head domain-containing protein;Forkhead box protein O Caenorhabditis elegans 210-216 5821009-0 1969 The interaction of cytochrome c with monolayers of phosphatidylethanolamine. phosphatidylethanolamine 51-75 cytochrome c, somatic Homo sapiens 19-31 5821009-2 1969 The interaction between [(14)C]carboxymethylated cytochrome c and monolayers of egg phosphatidylethanolamine at the air/water interface has been investigated by measurements of surface radioactivity, pressure and potential. phosphatidylethanolamine 84-108 cytochrome c, somatic Homo sapiens 49-61 5821009-13 1969 On compressing a phosphatidylethanolamine film containing penetrated cytochrome c to 40dynes/cm. phosphatidylethanolamine 17-41 cytochrome c, somatic Homo sapiens 69-81 33909989-1 2021 Autophagy is a fundamental catabolic process that uses a unique post-translational modification, the conjugation of ATG8 protein to phosphatidylethanolamine (PE). phosphatidylethanolamine 158-160 GABA type A receptor associated protein like 1 Homo sapiens 116-120 33722607-0 2021 Choline restores respiration in Psd1-deficient yeast by replenishing mitochondrial phosphatidylethanolamine. phosphatidylethanolamine 83-107 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 32-36 33484950-3 2021 METHODS: Since selenoprotein I (SELENOI) is an enzyme participating in two metabolic pathways for the synthesis of phosphatidylethanolamine (PE) and plasmenyl PE, we generated SELENOI deficient mouse models to determine loss-of-function effects on metabolic reprogramming during T cell activation. phosphatidylethanolamine 115-139 selenoprotein I Mus musculus 15-30 33484950-3 2021 METHODS: Since selenoprotein I (SELENOI) is an enzyme participating in two metabolic pathways for the synthesis of phosphatidylethanolamine (PE) and plasmenyl PE, we generated SELENOI deficient mouse models to determine loss-of-function effects on metabolic reprogramming during T cell activation. phosphatidylethanolamine 115-139 selenoprotein I Mus musculus 32-39 33484950-3 2021 METHODS: Since selenoprotein I (SELENOI) is an enzyme participating in two metabolic pathways for the synthesis of phosphatidylethanolamine (PE) and plasmenyl PE, we generated SELENOI deficient mouse models to determine loss-of-function effects on metabolic reprogramming during T cell activation. phosphatidylethanolamine 141-143 selenoprotein I Mus musculus 15-30 33484950-3 2021 METHODS: Since selenoprotein I (SELENOI) is an enzyme participating in two metabolic pathways for the synthesis of phosphatidylethanolamine (PE) and plasmenyl PE, we generated SELENOI deficient mouse models to determine loss-of-function effects on metabolic reprogramming during T cell activation. phosphatidylethanolamine 141-143 selenoprotein I Mus musculus 32-39 33484950-3 2021 METHODS: Since selenoprotein I (SELENOI) is an enzyme participating in two metabolic pathways for the synthesis of phosphatidylethanolamine (PE) and plasmenyl PE, we generated SELENOI deficient mouse models to determine loss-of-function effects on metabolic reprogramming during T cell activation. phosphatidylethanolamine 141-143 selenoprotein I Mus musculus 176-183 33893090-2 2021 Cargo initiates phagophore biogenesis, which entails the conjugation of LC3 to phosphatidylethanolamine. phosphatidylethanolamine 79-103 microtubule associated protein 1 light chain 3 alpha Homo sapiens 72-75 33462666-6 2021 There are ample evidences to the fact that PE may also bind to Annexin V (ANV), the PS-specific probe, at higher than 10 mol% PE concentrations and absence of Ca2+ ions. phosphatidylethanolamine 43-45 annexin A5 Homo sapiens 63-72 33462666-6 2021 There are ample evidences to the fact that PE may also bind to Annexin V (ANV), the PS-specific probe, at higher than 10 mol% PE concentrations and absence of Ca2+ ions. phosphatidylethanolamine 126-128 annexin A5 Homo sapiens 63-72 33314291-2 2021 As the only proteolytic enzyme of the core mammalian autophagy proteins, autophagy-related protein 4 (ATG4) primes newly synthesized pro-light chain 3 (LC3) to form LC3-I that attaches to phosphatidylethanolamine and delipidates LC3-PE to LC3-I for recycling. phosphatidylethanolamine 188-212 microtubule associated protein 1 light chain 3 alpha Homo sapiens 133-150 33314291-2 2021 As the only proteolytic enzyme of the core mammalian autophagy proteins, autophagy-related protein 4 (ATG4) primes newly synthesized pro-light chain 3 (LC3) to form LC3-I that attaches to phosphatidylethanolamine and delipidates LC3-PE to LC3-I for recycling. phosphatidylethanolamine 188-212 microtubule associated protein 1 light chain 3 alpha Homo sapiens 152-155 33314291-2 2021 As the only proteolytic enzyme of the core mammalian autophagy proteins, autophagy-related protein 4 (ATG4) primes newly synthesized pro-light chain 3 (LC3) to form LC3-I that attaches to phosphatidylethanolamine and delipidates LC3-PE to LC3-I for recycling. phosphatidylethanolamine 188-212 microtubule associated protein 1 light chain 3 alpha Homo sapiens 165-168 33314291-2 2021 As the only proteolytic enzyme of the core mammalian autophagy proteins, autophagy-related protein 4 (ATG4) primes newly synthesized pro-light chain 3 (LC3) to form LC3-I that attaches to phosphatidylethanolamine and delipidates LC3-PE to LC3-I for recycling. phosphatidylethanolamine 188-212 microtubule associated protein 1 light chain 3 alpha Homo sapiens 165-168 33314291-2 2021 As the only proteolytic enzyme of the core mammalian autophagy proteins, autophagy-related protein 4 (ATG4) primes newly synthesized pro-light chain 3 (LC3) to form LC3-I that attaches to phosphatidylethanolamine and delipidates LC3-PE to LC3-I for recycling. phosphatidylethanolamine 188-212 microtubule associated protein 1 light chain 3 alpha Homo sapiens 165-168 33542532-4 2021 Given that PLA2G6 mutations relate to neurodegeneration, we examined fibroblasts from a patient with a Parkinson"s disease (PD)-associated mutation (fPDR747W) and found selectively decreased 15-HpETE-PE-hydrolyzing activity, 15-HpETE-PE accumulation and elevated sensitivity to ferroptosis. phosphatidylethanolamine 200-202 phospholipase A2 group VI Homo sapiens 11-17 33542532-4 2021 Given that PLA2G6 mutations relate to neurodegeneration, we examined fibroblasts from a patient with a Parkinson"s disease (PD)-associated mutation (fPDR747W) and found selectively decreased 15-HpETE-PE-hydrolyzing activity, 15-HpETE-PE accumulation and elevated sensitivity to ferroptosis. phosphatidylethanolamine 234-236 phospholipase A2 group VI Homo sapiens 11-17 33722607-4 2021 This rescue is dependent on the conversion of Cho to PC via the Kennedy pathway as well as on Psd2, an enzyme catalyzing PE biosynthesis in the endosome. phosphatidylethanolamine 121-123 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 94-98 33722607-5 2021 Metabolic labeling experiments reveal that in the absence of exogenously supplied Cho, PE biosynthesized via Psd2 is mostly directed to the methylation pathway for PC biosynthesis and is unavailable for replenishing mitochondrial PE in Psd1-deleted cells. phosphatidylethanolamine 87-89 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 109-113 33722607-5 2021 Metabolic labeling experiments reveal that in the absence of exogenously supplied Cho, PE biosynthesized via Psd2 is mostly directed to the methylation pathway for PC biosynthesis and is unavailable for replenishing mitochondrial PE in Psd1-deleted cells. phosphatidylethanolamine 87-89 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 236-240 33722607-5 2021 Metabolic labeling experiments reveal that in the absence of exogenously supplied Cho, PE biosynthesized via Psd2 is mostly directed to the methylation pathway for PC biosynthesis and is unavailable for replenishing mitochondrial PE in Psd1-deleted cells. phosphatidylethanolamine 230-232 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 109-113 33722607-6 2021 In this setting, stimulating the Kennedy pathway for PC biosynthesis by Cho spares Psd2-synthesized PE from the methylation pathway and redirects it to the mitochondria. phosphatidylethanolamine 100-102 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 83-87 33679610-12 2020 We focused on molecular mechanisms through which two proteins, a mitochondrial hemoprotein cytochrome c (cyt c), and non-heme Fe lipoxygenase (LOX), change their catalytic properties to fulfill new functions of generating oxygenated CL and PE species. phosphatidylethanolamine 240-242 cytochrome c, somatic Homo sapiens 91-103 33789160-1 2021 The membrane phospholipids phosphatidylcholine and phosphatidylethanolamine (PE) are synthesized de novo by the CDP-choline and CDP-ethanolamine (Kennedy) pathway, in which the extracellular substrates choline and ethanolamine are transported into the cell, phosphorylated, and coupled with diacylglycerol to form the final phospholipid product. phosphatidylethanolamine 51-75 cut like homeobox 1 Homo sapiens 112-115 33789160-1 2021 The membrane phospholipids phosphatidylcholine and phosphatidylethanolamine (PE) are synthesized de novo by the CDP-choline and CDP-ethanolamine (Kennedy) pathway, in which the extracellular substrates choline and ethanolamine are transported into the cell, phosphorylated, and coupled with diacylglycerol to form the final phospholipid product. phosphatidylethanolamine 51-75 cut like homeobox 1 Homo sapiens 128-131 33789160-1 2021 The membrane phospholipids phosphatidylcholine and phosphatidylethanolamine (PE) are synthesized de novo by the CDP-choline and CDP-ethanolamine (Kennedy) pathway, in which the extracellular substrates choline and ethanolamine are transported into the cell, phosphorylated, and coupled with diacylglycerol to form the final phospholipid product. phosphatidylethanolamine 77-79 cut like homeobox 1 Homo sapiens 112-115 33789160-1 2021 The membrane phospholipids phosphatidylcholine and phosphatidylethanolamine (PE) are synthesized de novo by the CDP-choline and CDP-ethanolamine (Kennedy) pathway, in which the extracellular substrates choline and ethanolamine are transported into the cell, phosphorylated, and coupled with diacylglycerol to form the final phospholipid product. phosphatidylethanolamine 77-79 cut like homeobox 1 Homo sapiens 128-131 33789160-8 2021 The lack of CTL1 in M2 cells reduced the ethanolamine transport, the flux through the CDP-ethanolamine Kennedy pathway, and PE synthesis. phosphatidylethanolamine 124-126 solute carrier family 44 member 1 Homo sapiens 12-16 33789160-9 2021 In contrast, overexpression of CTL1 in M2 cells improved ethanolamine transport and PE synthesis. phosphatidylethanolamine 84-86 solute carrier family 44 member 1 Homo sapiens 31-35 33789160-10 2021 These data firmly establish that CTL1 and CTL2 are the first identified ethanolamine transporters in whole cells and mitochondria, with intrinsic roles in de novo PE synthesis by the Kennedy pathway and intracellular redistribution of ethanolamine. phosphatidylethanolamine 163-165 solute carrier family 44 member 1 Homo sapiens 33-37 33789160-10 2021 These data firmly establish that CTL1 and CTL2 are the first identified ethanolamine transporters in whole cells and mitochondria, with intrinsic roles in de novo PE synthesis by the Kennedy pathway and intracellular redistribution of ethanolamine. phosphatidylethanolamine 163-165 solute carrier family 44 member 2 Homo sapiens 42-46 33479740-0 2021 Phosphatidylserine and Phosphatidylethanolamine Regulate the Structure and Function of FVIIaand Its Interaction with Soluble Tissue Factor. phosphatidylethanolamine 23-47 coagulation factor III, tissue factor Homo sapiens 125-138 33548224-5 2021 The mitochondria in hLrp1-/- mouse livers have an abnormal morphology and their membranes contain significantly less anionic phospholipids, including lower levels of phosphatidylethanolamine and cardiolipin that increase mitochondrial fission and impair fusion. phosphatidylethanolamine 166-190 LDL receptor related protein 1 Homo sapiens 20-25 33298241-1 2021 The bacterial effector protein RavZ from a pathogen can impair autophagy in the host by delipidating the mammalian autophagy-related gene 8 (mATG8)-phosphatidylethanolamine (PE) on autophagic membranes. phosphatidylethanolamine 148-172 microtubule-associated protein 1 light chain 3 beta Mus musculus 141-146 33298241-1 2021 The bacterial effector protein RavZ from a pathogen can impair autophagy in the host by delipidating the mammalian autophagy-related gene 8 (mATG8)-phosphatidylethanolamine (PE) on autophagic membranes. phosphatidylethanolamine 174-176 microtubule-associated protein 1 light chain 3 beta Mus musculus 141-146 33360238-5 2021 Under normal growth conditions, the ppi2 mutant accumulated significantly lower levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). phosphatidylethanolamine 116-140 proton pump interactor 2 Arabidopsis thaliana 36-40 33360238-5 2021 Under normal growth conditions, the ppi2 mutant accumulated significantly lower levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). phosphatidylethanolamine 142-144 proton pump interactor 2 Arabidopsis thaliana 36-40 33679610-12 2020 We focused on molecular mechanisms through which two proteins, a mitochondrial hemoprotein cytochrome c (cyt c), and non-heme Fe lipoxygenase (LOX), change their catalytic properties to fulfill new functions of generating oxygenated CL and PE species. phosphatidylethanolamine 240-242 cytochrome c, somatic Homo sapiens 105-110 33679610-13 2020 Given the high selectivity and specificity of CL and PE peroxidation we argue that enzymatic reactions catalyzed by cyt c/CL complexes and 15-lipoxygenase/phosphatidylethanolamine binding protein 1 (15LOX/PEBP1) complexes dominate, at least during the initiation stage of peroxidation, in apoptosis and ferroptosis. phosphatidylethanolamine 53-55 cytochrome c, somatic Homo sapiens 116-121 33679610-13 2020 Given the high selectivity and specificity of CL and PE peroxidation we argue that enzymatic reactions catalyzed by cyt c/CL complexes and 15-lipoxygenase/phosphatidylethanolamine binding protein 1 (15LOX/PEBP1) complexes dominate, at least during the initiation stage of peroxidation, in apoptosis and ferroptosis. phosphatidylethanolamine 53-55 arachidonate 15-lipoxygenase Homo sapiens 199-204 33679610-13 2020 Given the high selectivity and specificity of CL and PE peroxidation we argue that enzymatic reactions catalyzed by cyt c/CL complexes and 15-lipoxygenase/phosphatidylethanolamine binding protein 1 (15LOX/PEBP1) complexes dominate, at least during the initiation stage of peroxidation, in apoptosis and ferroptosis. phosphatidylethanolamine 53-55 phosphatidylethanolamine binding protein 1 Homo sapiens 205-210 33465374-8 2021 Cell sorting based on CD73 expression followed by LC-MS revealed distinct changes in PC and PE levels in CD73-positive rod photoreceptors and CD73-negative retinal cells. phosphatidylethanolamine 92-94 5' nucleotidase, ecto Mus musculus 105-109 32875694-3 2021 The spatial locations of the side chain carboxylates of Glu301 and Glu374, to which phosphatidylethanolamine is uniquely attached via an amide bond, define the anchoring points of eEF1A2 to cellular membranes and interorganellar membrane contact sites. phosphatidylethanolamine 84-108 eukaryotic translation elongation factor 1 alpha 2 Homo sapiens 180-186 33465374-8 2021 Cell sorting based on CD73 expression followed by LC-MS revealed distinct changes in PC and PE levels in CD73-positive rod photoreceptors and CD73-negative retinal cells. phosphatidylethanolamine 92-94 5' nucleotidase, ecto Mus musculus 105-109 33432112-0 2021 Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2. phosphatidylethanolamine 11-35 toll-like receptor 2 Mus musculus 100-104 33446636-1 2021 During autophagy the enzyme Atg3 catalyzes the covalent conjugation of LC3 to the amino group of phosphatidylethanolamine (PE) lipids, which is one of the key steps in autophagosome formation. phosphatidylethanolamine 97-121 autophagy related 3 Homo sapiens 28-32 33446636-1 2021 During autophagy the enzyme Atg3 catalyzes the covalent conjugation of LC3 to the amino group of phosphatidylethanolamine (PE) lipids, which is one of the key steps in autophagosome formation. phosphatidylethanolamine 97-121 microtubule associated protein 1 light chain 3 alpha Homo sapiens 71-74 33446636-1 2021 During autophagy the enzyme Atg3 catalyzes the covalent conjugation of LC3 to the amino group of phosphatidylethanolamine (PE) lipids, which is one of the key steps in autophagosome formation. phosphatidylethanolamine 123-125 autophagy related 3 Homo sapiens 28-32 33446636-1 2021 During autophagy the enzyme Atg3 catalyzes the covalent conjugation of LC3 to the amino group of phosphatidylethanolamine (PE) lipids, which is one of the key steps in autophagosome formation. phosphatidylethanolamine 123-125 microtubule associated protein 1 light chain 3 alpha Homo sapiens 71-74 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). phosphatidylethanolamine 64-88 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 0-45 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). phosphatidylethanolamine 64-88 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 47-52 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). phosphatidylethanolamine 64-88 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 227-232 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). phosphatidylethanolamine 64-88 PEBP (phosphatidylethanolamine-binding protein) family protein Arabidopsis thaliana 320-337 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). phosphatidylethanolamine 119-143 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 0-45 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). phosphatidylethanolamine 119-143 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 47-52 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). phosphatidylethanolamine 119-143 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 227-232 33268452-1 2021 PHOSPHORYLETHANOLAMINE CYTIDYLYLTRANSFERASE 1 (PECT1) regulates phosphatidylethanolamine biosynthesis and controls the phosphatidylethanolamine: phosphatidylcholine ratio in Arabidopsis thaliana Previous studies suggested that PECT1 regulates flowering time by modulating the interaction between phosphatidylcholine and FLOWERING LOCUS T (FT), a florigen, in the shoot apical meristem (SAM). phosphatidylethanolamine 119-143 PEBP (phosphatidylethanolamine-binding protein) family protein Arabidopsis thaliana 320-337 32956759-0 2021 A regulatory role of scavenger receptor class B type 1 in endocytosis and lipid droplet formation induced by liposomes containing phosphatidylethanolamine in HEK293T cells. phosphatidylethanolamine 130-154 scavenger receptor class B member 1 Homo sapiens 21-54 32956759-8 2021 Conversely, the expression of SR-B1 by transfection of an expression plasmid enhanced the uptake of PE-containing liposomes. phosphatidylethanolamine 100-102 scavenger receptor class B member 1 Homo sapiens 30-35 32956759-9 2021 After the internalization of PE-containing liposomes, they were colocalized with endosomes/lysosomes and SR-B1, which indicates that these liposomes are taken up in HEK293T cells at least partially through the endosomal/lysosomal pathway. phosphatidylethanolamine 29-31 scavenger receptor class B member 1 Homo sapiens 105-110 32956759-10 2021 A specific anti-SR-B1-antibody blocked the uptake of PE-containing liposomes in HEK293T cells while LD formation in these cells induced by PE-containing liposomes was suppressed by treatment with SR-B1 siRNA. phosphatidylethanolamine 53-55 scavenger receptor class B member 1 Homo sapiens 16-21 32956759-10 2021 A specific anti-SR-B1-antibody blocked the uptake of PE-containing liposomes in HEK293T cells while LD formation in these cells induced by PE-containing liposomes was suppressed by treatment with SR-B1 siRNA. phosphatidylethanolamine 139-141 scavenger receptor class B member 1 Homo sapiens 16-21 32956759-10 2021 A specific anti-SR-B1-antibody blocked the uptake of PE-containing liposomes in HEK293T cells while LD formation in these cells induced by PE-containing liposomes was suppressed by treatment with SR-B1 siRNA. phosphatidylethanolamine 139-141 scavenger receptor class B member 1 Homo sapiens 196-201 32956759-11 2021 These results demonstrate that SR-B1 functions as a receptor for the endocytosis of PE-containing liposomes and regulates the formation of LDs induced by PE-containing liposomes in HEK293T cells. phosphatidylethanolamine 84-86 scavenger receptor class B member 1 Homo sapiens 31-36 32956759-11 2021 These results demonstrate that SR-B1 functions as a receptor for the endocytosis of PE-containing liposomes and regulates the formation of LDs induced by PE-containing liposomes in HEK293T cells. phosphatidylethanolamine 154-156 scavenger receptor class B member 1 Homo sapiens 31-36 33383652-10 2020 Thus, Pla2g5 contributes to PE metabolization, PGE2 and PGD2 production independently of the type of activation, while in (IL-4)BM-Macs, Pla2g5 regulates selective lipid pathways and likely novel functions. phosphatidylethanolamine 28-30 phospholipase A2 group V Homo sapiens 6-12 32686895-2 2020 Lipidated LC3 proteins that are conjugated to phosphatidylethanolamine (PE) play a key role in autophagosome biogenesis. phosphatidylethanolamine 46-70 microtubule associated protein 1 light chain 3 alpha Homo sapiens 10-13 33383652-6 2020 Phosphatidylcholine (PC) was preferentially metabolized in (LPS+IFNgamma)BM-Macs and Phosphatidylethanolamine (PE) in (IL-4)BM-Macs, with Pla2g5 contributing mostly to metabolization of selected PE molecules. phosphatidylethanolamine 85-109 Ras and Rab interactor 2 Homo sapiens 127-131 33383652-6 2020 Phosphatidylcholine (PC) was preferentially metabolized in (LPS+IFNgamma)BM-Macs and Phosphatidylethanolamine (PE) in (IL-4)BM-Macs, with Pla2g5 contributing mostly to metabolization of selected PE molecules. phosphatidylethanolamine 111-113 interleukin 4 Homo sapiens 119-123 33454021-1 2020 The two branches of the Kennedy pathways (CDP-choline and CDP-ethanolamine) are the predominant pathways responsible for the synthesis of the most abundant phospholipids, phosphatidylcholine and phosphatidylethanolamine, respectively, in mammalian membranes. phosphatidylethanolamine 195-219 cut like homeobox 1 Homo sapiens 42-45 33454021-1 2020 The two branches of the Kennedy pathways (CDP-choline and CDP-ethanolamine) are the predominant pathways responsible for the synthesis of the most abundant phospholipids, phosphatidylcholine and phosphatidylethanolamine, respectively, in mammalian membranes. phosphatidylethanolamine 195-219 cut like homeobox 1 Homo sapiens 58-61 33115868-4 2020 The presence of PE on the same surface as PS dramatically enhances recognition of PS by PS-binding proteins such as GAS6, PROS, and TIM1. phosphatidylethanolamine 16-18 growth arrest specific 6 Equus caballus 116-120 33115868-5 2020 Liposomes containing both PE and PS bound to GAS6 and were engulfed by AXL-expressing cells much more efficiently than those containing PS alone. phosphatidylethanolamine 26-28 growth arrest specific 6 Equus caballus 45-49 33115868-5 2020 Liposomes containing both PE and PS bound to GAS6 and were engulfed by AXL-expressing cells much more efficiently than those containing PS alone. phosphatidylethanolamine 26-28 AXL receptor tyrosine kinase Equus caballus 71-74 33115868-6 2020 Further, infection of AXL-expressing cells by infectious Zika virus or Ebola, Chikungunya or eastern equine encephalitis pseudoviruses was inhibited with greater efficiency by the liposomes containing both PS and PE compared to a mixture of liposomes separately composed of PS and PE. phosphatidylethanolamine 213-215 AXL receptor tyrosine kinase Homo sapiens 22-25 33115868-6 2020 Further, infection of AXL-expressing cells by infectious Zika virus or Ebola, Chikungunya or eastern equine encephalitis pseudoviruses was inhibited with greater efficiency by the liposomes containing both PS and PE compared to a mixture of liposomes separately composed of PS and PE. phosphatidylethanolamine 281-283 AXL receptor tyrosine kinase Homo sapiens 22-25 32686895-2 2020 Lipidated LC3 proteins that are conjugated to phosphatidylethanolamine (PE) play a key role in autophagosome biogenesis. phosphatidylethanolamine 72-74 microtubule associated protein 1 light chain 3 alpha Homo sapiens 10-13 31880198-8 2020 In conclusion, our research reveals a novel molecular mechanism that oxidative modification at Cys292 and Cys361 sites regulates ATG4B function, which modulates autophagy.Abbreviations: Air-ox: air-oxidation; ATG4B: autophagy related 4B cysteine peptidase; BCNU: 1,3-bis(2-chloroethyl)-1-nitrosourea; CBB: Coomassie Brilliant Blue; CM: complete medium; CQ: chloroquine; DTT: dithiothreitol; GSH: reduced glutathione; GSNO: S-nitrosoglutathione; GSSG: oxidized glutathione; HMW: high molecular weight; H2O2: hydrogen peroxide; NAC: N-acetyl-L-cysteine; NEM: N-ethylmaleimide; PE: phosphatidylethanolamine; PTM: post-translational modification; ROS, reactive oxygen species; WT: wild type. phosphatidylethanolamine 579-603 autophagy related 4B cysteine peptidase Homo sapiens 129-134 32999028-3 2020 In this study, we investigated the role of PE biosynthesis in herpes simplex virus 1 (HSV-1) infection by knocking out the host cell gene encoding phosphate cytidylyltransferase 2, ethanolamine (Pcyt2), which is a key rate-limiting enzyme in one of the two major pathways for PE biosynthesis. phosphatidylethanolamine 276-278 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 195-200 32999028-7 2020 These results indicated that PE biosynthesis mediated by Pcyt2 was required for efficient HSV-1 envelopment in the cytoplasm of infected cells and for viral replication and pathogenicity in vivo The results also identified the PE biosynthetic pathway as a possible novel target for antiviral therapy of HSV-associated diseases and raised an interesting possibility for meclizine repositioning for treatment of these diseases, since it is an over-the-counter drug that has been used for decades against nausea and vertigo in motion sickness.IMPORTANCE Glycerophospholipids in cell membranes and virus envelopes often affect viral entry and budding. phosphatidylethanolamine 29-31 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 57-62 32999028-9 2020 In this study, we have presented data showing that cellular PE biosynthesis mediated by Pcyt2 is important for HSV-1 envelopment in the cytoplasm, as well as for viral replication and pathogenicity in vivo This is the first report showing the importance of PE biosynthesis in herpesvirus infections. phosphatidylethanolamine 60-62 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 88-93 32999028-9 2020 In this study, we have presented data showing that cellular PE biosynthesis mediated by Pcyt2 is important for HSV-1 envelopment in the cytoplasm, as well as for viral replication and pathogenicity in vivo This is the first report showing the importance of PE biosynthesis in herpesvirus infections. phosphatidylethanolamine 257-259 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 88-93 32883522-9 2020 In addition, the hepatic lipidomic analysis results revealed that the contents of C22:6n-3 in phosphatidyl ethanolamine (PE-DHA) and PE-C22 PUFAs were more easily affected by the absence of elovl2 and elovl5. phosphatidylethanolamine 94-119 ELOVL fatty acid elongase 5 Danio rerio 201-207 31880198-8 2020 In conclusion, our research reveals a novel molecular mechanism that oxidative modification at Cys292 and Cys361 sites regulates ATG4B function, which modulates autophagy.Abbreviations: Air-ox: air-oxidation; ATG4B: autophagy related 4B cysteine peptidase; BCNU: 1,3-bis(2-chloroethyl)-1-nitrosourea; CBB: Coomassie Brilliant Blue; CM: complete medium; CQ: chloroquine; DTT: dithiothreitol; GSH: reduced glutathione; GSNO: S-nitrosoglutathione; GSSG: oxidized glutathione; HMW: high molecular weight; H2O2: hydrogen peroxide; NAC: N-acetyl-L-cysteine; NEM: N-ethylmaleimide; PE: phosphatidylethanolamine; PTM: post-translational modification; ROS, reactive oxygen species; WT: wild type. phosphatidylethanolamine 579-603 autophagy related 4B cysteine peptidase Homo sapiens 209-214 32732290-1 2020 During autophagy, LC3 and GABARAP proteins become covalently attached to phosphatidylethanolamine on the growing autophagosome. phosphatidylethanolamine 73-97 microtubule associated protein 1 light chain 3 alpha Homo sapiens 18-21 32502648-1 2020 Phosphatidylethanolamine N-methyltransferase (PEMT) is a small integral membrane protein that converts phosphatidylethanolamine (PE) into phosphatidylcholine (PC). phosphatidylethanolamine 103-127 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 32502648-1 2020 Phosphatidylethanolamine N-methyltransferase (PEMT) is a small integral membrane protein that converts phosphatidylethanolamine (PE) into phosphatidylcholine (PC). phosphatidylethanolamine 103-127 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 32502648-1 2020 Phosphatidylethanolamine N-methyltransferase (PEMT) is a small integral membrane protein that converts phosphatidylethanolamine (PE) into phosphatidylcholine (PC). phosphatidylethanolamine 46-48 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 32978330-0 2020 Withdrawal: A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization. phosphatidylethanolamine 26-50 tumor necrosis factor Homo sapiens 75-102 32732290-1 2020 During autophagy, LC3 and GABARAP proteins become covalently attached to phosphatidylethanolamine on the growing autophagosome. phosphatidylethanolamine 73-97 GABA type A receptor-associated protein Homo sapiens 26-33 32978330-0 2020 Withdrawal: A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization. phosphatidylethanolamine 191-215 tumor necrosis factor Homo sapiens 75-102 32966473-0 2020 Exogenous natural EPA-enriched phosphatidylcholine and phosphatidylethanolamine ameliorate lipid accumulation and insulin resistance via activation of PPARalpha/gamma in mice. phosphatidylethanolamine 55-79 peroxisome proliferator activated receptor alpha Mus musculus 151-160 32966473-2 2020 Here, in a protein-lipid overlay assay, we show that EPA-enriched phosphatidylcholine (EPA-PC) and phosphatidylethanolamine (EPA-PE), isolated from sea cucumber, bind to PPARalpha/PPARgamma. phosphatidylethanolamine 99-123 peroxisome proliferator activated receptor alpha Mus musculus 170-179 32966473-2 2020 Here, in a protein-lipid overlay assay, we show that EPA-enriched phosphatidylcholine (EPA-PC) and phosphatidylethanolamine (EPA-PE), isolated from sea cucumber, bind to PPARalpha/PPARgamma. phosphatidylethanolamine 99-123 peroxisome proliferator activated receptor gamma Mus musculus 180-189 31818185-12 2020 Our findings suggest a new regulatory link between mitochondria and autophagy through CASP9 activity, especially for the proper operation of the Atg8-family conjugation system and autophagosome closure and maturation.Abbreviations: AA: amino acid; ACD: autophagic cell death; ACTB: actin beta; ANXA5: annexin A5; APAF1: apoptotic peptidase activating factor 1; Atg: autophagy related; ATG16L1: autophagy related 16 like 1; BafA1: bafilomycin A1; BCL2: BCL2 apoptosis regulator; BECN1: beclin 1; CARD: caspase recruitment domain containing; CASP: caspase; CM-H2DCFDA: chloromethyl-2",7"-dichlorodihydrofluorescein diacetate; Deltapsim: mitochondrial membrane potential; DN: dominant-negative; DNM1L/DRP1: dynamin 1 like; EBSS: Earle"s balanced salt solution; GABARAP: GABA type A receptor-associated protein; GABARAPL1: GABA type A receptor associated protein like 1; GABARAPL2: GABA type A receptor associated protein like 2; HCN: hippocampal neural stem cells; IAM: inner autophagosome membrane; INS: insulin; KO: knockout; LEHD: Z-LEHD-fmk; MAP1LC3: microtubule associated protein 1 light chain 3; MFN1: mitofusin 1; MFN2: mitofusin 2; MTORC1: mechanistic target of rapamycin kinase complex 1; PARP1: poly(ADP-ribose) polymerase 1; PBS: phosphate-buffered saline; PE: phosphatidylethanolamine; ROS: reactive oxygen species; sgRNA: single guide RNA; SR-SIM: super-resolution structured illumination microscopy; SQSTM1: sequestosome 1; STS: staurosporine; STX17: syntaxin 17; TMRE: tetramethylrhodamine ethyl ester; TUBB: tubulin beta class I; ULK1: unc-51 like autophagy activating kinase 1; WT: wild type; ZFYVE1/DFCP1: zinc finger FYVE-type containing 1. phosphatidylethanolamine 1270-1294 caspase 9 Homo sapiens 86-91 31818185-12 2020 Our findings suggest a new regulatory link between mitochondria and autophagy through CASP9 activity, especially for the proper operation of the Atg8-family conjugation system and autophagosome closure and maturation.Abbreviations: AA: amino acid; ACD: autophagic cell death; ACTB: actin beta; ANXA5: annexin A5; APAF1: apoptotic peptidase activating factor 1; Atg: autophagy related; ATG16L1: autophagy related 16 like 1; BafA1: bafilomycin A1; BCL2: BCL2 apoptosis regulator; BECN1: beclin 1; CARD: caspase recruitment domain containing; CASP: caspase; CM-H2DCFDA: chloromethyl-2",7"-dichlorodihydrofluorescein diacetate; Deltapsim: mitochondrial membrane potential; DN: dominant-negative; DNM1L/DRP1: dynamin 1 like; EBSS: Earle"s balanced salt solution; GABARAP: GABA type A receptor-associated protein; GABARAPL1: GABA type A receptor associated protein like 1; GABARAPL2: GABA type A receptor associated protein like 2; HCN: hippocampal neural stem cells; IAM: inner autophagosome membrane; INS: insulin; KO: knockout; LEHD: Z-LEHD-fmk; MAP1LC3: microtubule associated protein 1 light chain 3; MFN1: mitofusin 1; MFN2: mitofusin 2; MTORC1: mechanistic target of rapamycin kinase complex 1; PARP1: poly(ADP-ribose) polymerase 1; PBS: phosphate-buffered saline; PE: phosphatidylethanolamine; ROS: reactive oxygen species; sgRNA: single guide RNA; SR-SIM: super-resolution structured illumination microscopy; SQSTM1: sequestosome 1; STS: staurosporine; STX17: syntaxin 17; TMRE: tetramethylrhodamine ethyl ester; TUBB: tubulin beta class I; ULK1: unc-51 like autophagy activating kinase 1; WT: wild type; ZFYVE1/DFCP1: zinc finger FYVE-type containing 1. phosphatidylethanolamine 1270-1294 cartilage associated protein Homo sapiens 86-90 32502470-1 2020 Selenoprotein I (SELENOI) is an ethanolamine phosphotransferase that catalyzes the third reaction of the Kennedy pathway for the synthesis of phosphatidylethanolamine. phosphatidylethanolamine 142-166 selenoprotein I Mus musculus 0-15 32502470-1 2020 Selenoprotein I (SELENOI) is an ethanolamine phosphotransferase that catalyzes the third reaction of the Kennedy pathway for the synthesis of phosphatidylethanolamine. phosphatidylethanolamine 142-166 selenoprotein I Mus musculus 17-24 32851152-4 2020 Lipid-protein interactions with phosphatidylserine and phosphatidylethanolamine lipids, in particular, stabilize the residues 374 to 390 of NTS1 into forming a helix. phosphatidylethanolamine 55-79 neurotensin Homo sapiens 140-144 32626969-3 2020 Autophagy-related gene 4a (ATG4a) cleaves autophagy-related protein 8 (Atg8) near the C terminus, allowing Atg8 to conjugate with phosphatidylethanolamine via the exposed glycine; although this is pivotal in cancer development, no study has yet linked it to eye diseases. phosphatidylethanolamine 130-154 autophagy related 4A cysteine peptidase Homo sapiens 27-32 32576654-6 2020 EPT1 also contributed to the synthesis of PE species containing the fatty acids 36:1, 36:4, 38:5, 38:4, 38:3, 40:6, 40:5, and 40:4. phosphatidylethanolamine 42-44 selenoprotein I Homo sapiens 0-4 32626969-3 2020 Autophagy-related gene 4a (ATG4a) cleaves autophagy-related protein 8 (Atg8) near the C terminus, allowing Atg8 to conjugate with phosphatidylethanolamine via the exposed glycine; although this is pivotal in cancer development, no study has yet linked it to eye diseases. phosphatidylethanolamine 130-154 GABA type A receptor associated protein like 1 Homo sapiens 42-69 32626969-3 2020 Autophagy-related gene 4a (ATG4a) cleaves autophagy-related protein 8 (Atg8) near the C terminus, allowing Atg8 to conjugate with phosphatidylethanolamine via the exposed glycine; although this is pivotal in cancer development, no study has yet linked it to eye diseases. phosphatidylethanolamine 130-154 GABA type A receptor associated protein like 1 Homo sapiens 71-75 32626969-3 2020 Autophagy-related gene 4a (ATG4a) cleaves autophagy-related protein 8 (Atg8) near the C terminus, allowing Atg8 to conjugate with phosphatidylethanolamine via the exposed glycine; although this is pivotal in cancer development, no study has yet linked it to eye diseases. phosphatidylethanolamine 130-154 GABA type A receptor associated protein like 1 Homo sapiens 107-111 32295848-6 2020 Additionally, the amount of phosphatidylethanolamine (PE) on the cell surface was attenuated in LDLR/LOX-1 dKO and LDLR sKO pre-OCLs, while the PE distribution in wild-type OCLs was concentrated on the filopodia in contact with neighboring cells. phosphatidylethanolamine 28-52 low density lipoprotein receptor Mus musculus 96-100 32637097-9 2020 BTN1A1 gene knockout increased the percentage of phosphatidylethanolamine (PE) and decreased phosphatidylcholine (PC), which resulted in a lower PC/PE ratio. phosphatidylethanolamine 49-73 BTN1A1 Bos taurus 0-6 32637097-9 2020 BTN1A1 gene knockout increased the percentage of phosphatidylethanolamine (PE) and decreased phosphatidylcholine (PC), which resulted in a lower PC/PE ratio. phosphatidylethanolamine 75-77 BTN1A1 Bos taurus 0-6 32637097-9 2020 BTN1A1 gene knockout increased the percentage of phosphatidylethanolamine (PE) and decreased phosphatidylcholine (PC), which resulted in a lower PC/PE ratio. phosphatidylethanolamine 148-150 BTN1A1 Bos taurus 0-6 32543783-3 2020 LDLR knockdown also down-regulated ether-linked phosphatidylethanolamine (PE-O, lysosomes or peroxisomes) and up-regulated lysophosphatidylcholine [LPC, lipid droplet (LD)]. phosphatidylethanolamine 48-72 low density lipoprotein receptor Homo sapiens 0-4 32543783-3 2020 LDLR knockdown also down-regulated ether-linked phosphatidylethanolamine (PE-O, lysosomes or peroxisomes) and up-regulated lysophosphatidylcholine [LPC, lipid droplet (LD)]. phosphatidylethanolamine 74-78 low density lipoprotein receptor Homo sapiens 0-4 32596242-4 2020 The ATG8 protein is conjugated to the membrane lipid phosphatidylethanolamine in a ubiquitin-like conjugation reaction that is essential for autophagosome formation. phosphatidylethanolamine 53-77 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 4-8 32515645-1 2021 Coupling of Atg8 to phosphatidylethanolamine is crucial for the expansion of the crescent-shaped phagophore during cargo engulfment. phosphatidylethanolamine 20-44 GABA type A receptor associated protein like 1 Homo sapiens 12-16 32582149-7 2020 This was at least in part due to the lower expression of phosphatidylethanolamine N-methyltransferase (pemt), an enzyme that converts PE to phosphatidylcholine (PC). phosphatidylethanolamine 134-136 phosphatidylethanolamine N-methyltransferase Mus musculus 57-101 32582149-7 2020 This was at least in part due to the lower expression of phosphatidylethanolamine N-methyltransferase (pemt), an enzyme that converts PE to phosphatidylcholine (PC). phosphatidylethanolamine 134-136 phosphatidylethanolamine N-methyltransferase Mus musculus 103-107 32393038-10 2020 Upon addition of PSO4, at room temperature, the PC fraction gradually converted into the liquid ordered (Lo) phase while the (PE + PA) fraction remained unaffected. phosphatidylethanolamine 126-128 pre-mRNA processing factor 19 Homo sapiens 17-21 32058032-0 2020 Vps39 is required for ethanolamine-stimulated elevation in mitochondrial phosphatidylethanolamine. phosphatidylethanolamine 73-97 VPS39 subunit of HOPS complex Homo sapiens 0-5 32058032-3 2020 Utilizing a genetic approach focused on these membrane contact site proteins, we have discovered a "moonlighting" role of the membrane contact site and vesicular fusion protein, Vps39, in phosphatidylethanolamine (PE) transport to the mitochondria. phosphatidylethanolamine 188-212 VPS39 subunit of HOPS complex Homo sapiens 178-183 32058032-3 2020 Utilizing a genetic approach focused on these membrane contact site proteins, we have discovered a "moonlighting" role of the membrane contact site and vesicular fusion protein, Vps39, in phosphatidylethanolamine (PE) transport to the mitochondria. phosphatidylethanolamine 214-216 VPS39 subunit of HOPS complex Homo sapiens 178-183 32058032-4 2020 We show that the deletion of Vps39 prevents ethanolamine-stimulated elevation of mitochondrial PE levels without affecting PE biosynthesis in the ER or its transport to other sub-cellular organelles. phosphatidylethanolamine 95-97 VPS39 subunit of HOPS complex Homo sapiens 29-34 32058032-8 2020 Our work thus identifies Vps39 as a novel player in ethanolamine-stimulated PE transport to the mitochondria. phosphatidylethanolamine 76-78 VPS39 subunit of HOPS complex Homo sapiens 25-30 32269127-6 2020 Depletion of Sac1 inhibited the recruitment of Rab5 GTPase-positive endosomes and enrichment of phosphatidylethanolamine in the viral replication compartment. phosphatidylethanolamine 96-120 SAC1 like phosphatidylinositide phosphatase Homo sapiens 13-17 32269127-13 2020 We found that Sac1 affects the recruitment of other host factors and enrichment of phosphatidylethanolamine and sterol lipids within the subverted host membranes to promote optimal viral replication. phosphatidylethanolamine 83-107 SAC1 like phosphatidylinositide phosphatase Homo sapiens 14-18 31828718-6 2020 PE-binding capacity of Al[18F]F-NOTA-PEG3-duramycin was determined in a competitive radiometric PE-binding assay. phosphatidylethanolamine 0-2 paternally expressed 3 Mus musculus 32-41 31828718-11 2020 A competitive radiometric PE-binding assay strongly confirmed the binding of Al[18F]F-NOTA-PEG3-duramycin to PE. phosphatidylethanolamine 26-28 paternally expressed 3 Mus musculus 86-95 32295848-6 2020 Additionally, the amount of phosphatidylethanolamine (PE) on the cell surface was attenuated in LDLR/LOX-1 dKO and LDLR sKO pre-OCLs, while the PE distribution in wild-type OCLs was concentrated on the filopodia in contact with neighboring cells. phosphatidylethanolamine 28-52 oxidized low density lipoprotein (lectin-like) receptor 1 Mus musculus 101-106 32295848-6 2020 Additionally, the amount of phosphatidylethanolamine (PE) on the cell surface was attenuated in LDLR/LOX-1 dKO and LDLR sKO pre-OCLs, while the PE distribution in wild-type OCLs was concentrated on the filopodia in contact with neighboring cells. phosphatidylethanolamine 28-52 low density lipoprotein receptor Mus musculus 115-119 32295848-6 2020 Additionally, the amount of phosphatidylethanolamine (PE) on the cell surface was attenuated in LDLR/LOX-1 dKO and LDLR sKO pre-OCLs, while the PE distribution in wild-type OCLs was concentrated on the filopodia in contact with neighboring cells. phosphatidylethanolamine 54-56 low density lipoprotein receptor Mus musculus 96-100 32295848-6 2020 Additionally, the amount of phosphatidylethanolamine (PE) on the cell surface was attenuated in LDLR/LOX-1 dKO and LDLR sKO pre-OCLs, while the PE distribution in wild-type OCLs was concentrated on the filopodia in contact with neighboring cells. phosphatidylethanolamine 54-56 oxidized low density lipoprotein (lectin-like) receptor 1 Mus musculus 101-106 32295848-6 2020 Additionally, the amount of phosphatidylethanolamine (PE) on the cell surface was attenuated in LDLR/LOX-1 dKO and LDLR sKO pre-OCLs, while the PE distribution in wild-type OCLs was concentrated on the filopodia in contact with neighboring cells. phosphatidylethanolamine 54-56 low density lipoprotein receptor Mus musculus 115-119 32397394-2 2020 Dictyostelium discoideum atg5 single, atg5/12 double, and atg5/12/16 triple gene knock-out mutant strains displayed similar defects in the conjugation of ATG8 to phosphatidylethanolamine, development, and cell viability upon nitrogen starvation. phosphatidylethanolamine 162-186 Atg5p Saccharomyces cerevisiae S288C 25-29 32377373-1 2020 ATG8 family proteins are evolutionary conserved ubiquitin-like modifiers, which become attached to the headgroup of the membrane lipid phosphatidylethanolamine in a process referred to as lipidation. phosphatidylethanolamine 135-159 GABA type A receptor associated protein like 1 Homo sapiens 0-4 32303746-1 2020 The yeast phosphatidylserine (PtdSer) decarboxylase Psd2 is proposed to engage in a membrane contact site (MCS) for PtdSer decarboxylation to phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 142-166 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 52-56 31968125-0 2020 Phosphatidylethanolamine accelerates aggregation of the amyloidogenic N-terminal fragment of apoA-I. phosphatidylethanolamine 0-24 apolipoprotein A1 Homo sapiens 93-99 31968125-2 2020 Here, we found that phosphatidylethanolamine (PE) accelerates aggregation of the N-terminal 1-83 fragment of an amyloidogenic G26R variant of apoA-I on lipid membranes. phosphatidylethanolamine 20-44 apolipoprotein A1 Homo sapiens 142-148 31968125-2 2020 Here, we found that phosphatidylethanolamine (PE) accelerates aggregation of the N-terminal 1-83 fragment of an amyloidogenic G26R variant of apoA-I on lipid membranes. phosphatidylethanolamine 46-48 apolipoprotein A1 Homo sapiens 142-148 31968125-4 2020 Rather, fluorescence measurements indicated that PE induces more ordered lipid packing at the interfacial and acyl chain regions, providing more hydrophobic environments especially around the highly amyloidogenic regions in apoA-I on the membrane surface. phosphatidylethanolamine 49-51 apolipoprotein A1 Homo sapiens 224-230 31968125-5 2020 These results suggest that PE promotes aggregation of the amyloidogenic N-terminal fragment of apoA-I on lipid membranes by inducing hydrophobic membrane environments. phosphatidylethanolamine 27-29 apolipoprotein A1 Homo sapiens 95-101 32144202-10 2020 Furthermore, utilizing a genome-wide siRNA screen in HeLa cells to search for regulators of PGAM5 cleavage, we identified a set of candidate genes, including phosphatidylserine decarboxylase (PISD), which catalyzes the formation of phosphatidylethanolamine at the mitochondrial membrane. phosphatidylethanolamine 232-256 PGAM family member 5, mitochondrial serine/threonine protein phosphatase Homo sapiens 92-97 32144202-10 2020 Furthermore, utilizing a genome-wide siRNA screen in HeLa cells to search for regulators of PGAM5 cleavage, we identified a set of candidate genes, including phosphatidylserine decarboxylase (PISD), which catalyzes the formation of phosphatidylethanolamine at the mitochondrial membrane. phosphatidylethanolamine 232-256 phosphatidylserine decarboxylase Homo sapiens 158-190 32144202-10 2020 Furthermore, utilizing a genome-wide siRNA screen in HeLa cells to search for regulators of PGAM5 cleavage, we identified a set of candidate genes, including phosphatidylserine decarboxylase (PISD), which catalyzes the formation of phosphatidylethanolamine at the mitochondrial membrane. phosphatidylethanolamine 232-256 phosphatidylserine decarboxylase Homo sapiens 192-196 32277540-1 2020 Atg3-catalyzed transferring of Atg8 to phosphatidylethanolamine (PE) in phagophore membrane is essential for autophagy. phosphatidylethanolamine 39-63 autophagy related 3 Homo sapiens 0-4 32277540-1 2020 Atg3-catalyzed transferring of Atg8 to phosphatidylethanolamine (PE) in phagophore membrane is essential for autophagy. phosphatidylethanolamine 39-63 GABA type A receptor associated protein like 1 Homo sapiens 31-35 32277540-1 2020 Atg3-catalyzed transferring of Atg8 to phosphatidylethanolamine (PE) in phagophore membrane is essential for autophagy. phosphatidylethanolamine 65-67 autophagy related 3 Homo sapiens 0-4 32277540-1 2020 Atg3-catalyzed transferring of Atg8 to phosphatidylethanolamine (PE) in phagophore membrane is essential for autophagy. phosphatidylethanolamine 65-67 GABA type A receptor associated protein like 1 Homo sapiens 31-35 31876221-2 2020 One gene known to control flowering time is TERMINAL FLOWER 1 (TFL1), which belongs to a family of phosphatidylethanolamine binding proteins, which can either repress or promote flowering time. phosphatidylethanolamine 99-123 PEBP (phosphatidylethanolamine-binding protein) family protein Arabidopsis thaliana 63-67 32303746-1 2020 The yeast phosphatidylserine (PtdSer) decarboxylase Psd2 is proposed to engage in a membrane contact site (MCS) for PtdSer decarboxylation to phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 168-174 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 52-56 31783151-0 2020 Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamine. phosphatidylethanolamine 146-170 ethanolamine-phosphate phospho-lyase Homo sapiens 96-103 31901645-2 2020 ATG8 (LC3s and gamma-aminobutyric acid receptor-associated proteins in mammals) and ATG12 are covalently conjugated to phosphatidylethanolamine and ATG5, respectively. phosphatidylethanolamine 119-143 GABA type A receptor associated protein like 1 Homo sapiens 0-4 31901645-2 2020 ATG8 (LC3s and gamma-aminobutyric acid receptor-associated proteins in mammals) and ATG12 are covalently conjugated to phosphatidylethanolamine and ATG5, respectively. phosphatidylethanolamine 119-143 microtubule associated protein 1 light chain 3 alpha Homo sapiens 6-9 31901645-2 2020 ATG8 (LC3s and gamma-aminobutyric acid receptor-associated proteins in mammals) and ATG12 are covalently conjugated to phosphatidylethanolamine and ATG5, respectively. phosphatidylethanolamine 119-143 autophagy related 12 Homo sapiens 84-89 31757360-6 2020 First, a computational modeling approach by coarse-grained molecular dynamics simulation of the whole TRPV1 embedded in a phosphatidylcholine and phosphatidylethanolamine membrane provides insight into the dynamics of this channel domain. phosphatidylethanolamine 146-170 transient receptor potential cation channel subfamily V member 1 Homo sapiens 102-107 32043504-0 2020 EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine enhance BDNF/TrkB/CREB signaling and inhibit neuronal apoptosis in vitro and in vivo. phosphatidylethanolamine 55-79 brain-derived neurotrophic factor Rattus norvegicus 88-92 32043504-0 2020 EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine enhance BDNF/TrkB/CREB signaling and inhibit neuronal apoptosis in vitro and in vivo. phosphatidylethanolamine 55-79 neurotrophic receptor tyrosine kinase 2 Rattus norvegicus 93-97 32043504-0 2020 EPA-enriched ethanolamine plasmalogen and EPA-enriched phosphatidylethanolamine enhance BDNF/TrkB/CREB signaling and inhibit neuronal apoptosis in vitro and in vivo. phosphatidylethanolamine 55-79 cAMP responsive element binding protein 1 Rattus norvegicus 98-102 31927911-3 2020 NAg exposure disintegrates the glycan backbone in the major cell wall component peptidoglycan, causes complete breakdown of lipoteichoic acid as well as disrupting the phosphate-amine and fatty acid groups in phosphatidylethanolamine, a membrane phospholipid. phosphatidylethanolamine 209-233 NBAS subunit of NRZ tethering complex Homo sapiens 0-3 31786280-5 2020 Point mutations altering entry gate residues in the first (Q209A) and fourth (S457Q) transmembrane segments of Neo1, where phospholipid substrate would initially be selected, disrupt PS and PE membrane asymmetry, but do not perturb growth of cells. phosphatidylethanolamine 190-192 putative aminophospholipid-translocating P4-type ATPase NEO1 Saccharomyces cerevisiae S288C 111-115 31786280-7 2020 We also identified a gain-of-function mutation in the second transmembrane segment of Neo1 (Neo1[Y222S]), predicted to help form the entry gate, that substantially enhances Neo1"s ability to replace the function of a well characterized phospholipid flippase, Drs2, in establishing PS and PE asymmetry. phosphatidylethanolamine 288-290 putative aminophospholipid-translocating P4-type ATPase NEO1 Saccharomyces cerevisiae S288C 86-90 31786280-7 2020 We also identified a gain-of-function mutation in the second transmembrane segment of Neo1 (Neo1[Y222S]), predicted to help form the entry gate, that substantially enhances Neo1"s ability to replace the function of a well characterized phospholipid flippase, Drs2, in establishing PS and PE asymmetry. phosphatidylethanolamine 288-290 putative aminophospholipid-translocating P4-type ATPase NEO1 Saccharomyces cerevisiae S288C 92-96 31786280-7 2020 We also identified a gain-of-function mutation in the second transmembrane segment of Neo1 (Neo1[Y222S]), predicted to help form the entry gate, that substantially enhances Neo1"s ability to replace the function of a well characterized phospholipid flippase, Drs2, in establishing PS and PE asymmetry. phosphatidylethanolamine 288-290 putative aminophospholipid-translocating P4-type ATPase NEO1 Saccharomyces cerevisiae S288C 92-96 31786280-7 2020 We also identified a gain-of-function mutation in the second transmembrane segment of Neo1 (Neo1[Y222S]), predicted to help form the entry gate, that substantially enhances Neo1"s ability to replace the function of a well characterized phospholipid flippase, Drs2, in establishing PS and PE asymmetry. phosphatidylethanolamine 288-290 aminophospholipid-translocating P4-type ATPase DRS2 Saccharomyces cerevisiae S288C 259-263 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 351-375 autophagy related 7 Homo sapiens 83-87 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 351-375 GABA type A receptor associated protein like 1 Homo sapiens 97-101 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 351-375 autophagy related 3 Homo sapiens 120-124 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 351-375 autophagy related 3 Homo sapiens 158-162 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 351-375 GABA type A receptor associated protein like 1 Homo sapiens 164-168 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 351-375 autophagy related 12 Homo sapiens 206-211 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 351-375 autophagy related 5 Homo sapiens 212-216 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 351-375 autophagy related 3 Homo sapiens 158-162 31146038-7 2020 PE may undergo turnover by the phospholipid: diacylglycerol acyltransferase Lro1p as first step in acyl chain remodeling. phosphatidylethanolamine 0-2 phospholipid:diacylglycerol acyltransferase Saccharomyces cerevisiae S288C 76-81 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 351-375 GABA type A receptor associated protein like 1 Homo sapiens 164-168 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 351-375 GABA type A receptor associated protein like 1 Homo sapiens 164-168 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 351-375 autophagy related 3 Homo sapiens 158-162 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 377-379 autophagy related 7 Homo sapiens 83-87 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 377-379 GABA type A receptor associated protein like 1 Homo sapiens 97-101 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 377-379 autophagy related 3 Homo sapiens 120-124 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 377-379 autophagy related 3 Homo sapiens 158-162 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 377-379 GABA type A receptor associated protein like 1 Homo sapiens 164-168 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 377-379 autophagy related 12 Homo sapiens 206-211 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 377-379 autophagy related 5 Homo sapiens 212-216 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 377-379 autophagy related 3 Homo sapiens 158-162 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 377-379 GABA type A receptor associated protein like 1 Homo sapiens 164-168 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 377-379 GABA type A receptor associated protein like 1 Homo sapiens 164-168 31690182-2 2020 This process is catalyzed by an E1-E2-E3 trienzyme cascade, in which an E1 enzyme, Atg7, directs Atg8 to its E2 enzyme, Atg3, forming a thioester bond-linked Atg3~ Atg8 intermediate; then the composite E3, Atg12-Atg5-Atg16, interacts with the Atg3~ Atg8 intermediate and promotes Atg8 transfer from the catalytic cysteine of Atg3 to the head group of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 377-379 autophagy related 3 Homo sapiens 158-162 31637422-1 2019 CTP:phosphoethanolamine cytidylyltransferase (ET), encoded by PCYT2, is the rate-limiting enzyme for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway. phosphatidylethanolamine 101-125 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 0-44 31815960-13 2019 Our study suggests that DENV regulates aminophospholipids, especially phosphatidylcholine and phosphatidylethanolamine, by inhibiting AGPAT1 expression to increase aminophospholipid availability for virus multiplication. phosphatidylethanolamine 94-118 1-acylglycerol-3-phosphate O-acyltransferase 1 Homo sapiens 134-140 31397519-1 2019 ATP8A2 is a P4-ATPase (adenosine triphosphate) that actively flips phosphatidylserine and phosphatidylethanolamine from the exoplasmic to the cytoplasmic leaflet of cell membranes to generate and maintain phospholipid asymmetry. phosphatidylethanolamine 90-114 ATPase phospholipid transporting 8A2 Homo sapiens 0-6 31397519-1 2019 ATP8A2 is a P4-ATPase (adenosine triphosphate) that actively flips phosphatidylserine and phosphatidylethanolamine from the exoplasmic to the cytoplasmic leaflet of cell membranes to generate and maintain phospholipid asymmetry. phosphatidylethanolamine 90-114 dynein axonemal heavy chain 8 Homo sapiens 15-21 31666384-3 2020 Mechanistic studies on viral particles revealed that labyrinthopeptins induce a virolytic effect through binding to the viral membrane lipid phosphatidylethanolamine (PE). phosphatidylethanolamine 141-165 procollagen C-endopeptidase enhancer Homo sapiens 167-169 31580889-1 2019 CTP: phosphoethanolamine cytidylyltransferase (Pcyt2) is the rate-limiting enzyme in mammalian phosphatidylethanolamine (PE) biosynthesis. phosphatidylethanolamine 95-119 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 0-45 31580889-1 2019 CTP: phosphoethanolamine cytidylyltransferase (Pcyt2) is the rate-limiting enzyme in mammalian phosphatidylethanolamine (PE) biosynthesis. phosphatidylethanolamine 95-119 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 47-52 31580889-1 2019 CTP: phosphoethanolamine cytidylyltransferase (Pcyt2) is the rate-limiting enzyme in mammalian phosphatidylethanolamine (PE) biosynthesis. phosphatidylethanolamine 121-123 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 0-45 31580889-1 2019 CTP: phosphoethanolamine cytidylyltransferase (Pcyt2) is the rate-limiting enzyme in mammalian phosphatidylethanolamine (PE) biosynthesis. phosphatidylethanolamine 121-123 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 47-52 31637422-1 2019 CTP:phosphoethanolamine cytidylyltransferase (ET), encoded by PCYT2, is the rate-limiting enzyme for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway. phosphatidylethanolamine 101-125 major facilitator superfamily domain containing 11 Homo sapiens 46-48 31637422-1 2019 CTP:phosphoethanolamine cytidylyltransferase (ET), encoded by PCYT2, is the rate-limiting enzyme for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway. phosphatidylethanolamine 101-125 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 62-67 32405618-2 2019 The absence of skeletal muscle phosphatidylethanolamine (PE) methyltransferase (PEMT) promotes an increase in skeletal muscle and whole-body metabolic rate to protect mice from diet-induced obesity. phosphatidylethanolamine 31-55 phosphatidylethanolamine N-methyltransferase Mus musculus 80-84 31807705-5 2019 Furthermore, PE binding to Pebp1 enhances the interaction of Pebp1 with IKKalpha/beta and reduces the phosphorylation of IKKalpha/beta. phosphatidylethanolamine 13-15 phosphatidylethanolamine binding protein 1 Homo sapiens 27-32 31807705-5 2019 Furthermore, PE binding to Pebp1 enhances the interaction of Pebp1 with IKKalpha/beta and reduces the phosphorylation of IKKalpha/beta. phosphatidylethanolamine 13-15 phosphatidylethanolamine binding protein 1 Homo sapiens 61-66 31807705-5 2019 Furthermore, PE binding to Pebp1 enhances the interaction of Pebp1 with IKKalpha/beta and reduces the phosphorylation of IKKalpha/beta. phosphatidylethanolamine 13-15 component of inhibitor of nuclear factor kappa B kinase complex Homo sapiens 72-80 31807705-5 2019 Furthermore, PE binding to Pebp1 enhances the interaction of Pebp1 with IKKalpha/beta and reduces the phosphorylation of IKKalpha/beta. phosphatidylethanolamine 13-15 component of inhibitor of nuclear factor kappa B kinase complex Homo sapiens 72-85 31807705-6 2019 The CDP-Etn-Pebp1 axis is associated with EMT/MET in hepatocyte differentiation, indicating that Etn/PE is a broad-spectrum MET/EMT-regulating metabolite. phosphatidylethanolamine 101-103 phosphatidylethanolamine binding protein 1 Homo sapiens 12-17 31807705-6 2019 The CDP-Etn-Pebp1 axis is associated with EMT/MET in hepatocyte differentiation, indicating that Etn/PE is a broad-spectrum MET/EMT-regulating metabolite. phosphatidylethanolamine 101-103 IL2 inducible T cell kinase Homo sapiens 42-45 31807705-6 2019 The CDP-Etn-Pebp1 axis is associated with EMT/MET in hepatocyte differentiation, indicating that Etn/PE is a broad-spectrum MET/EMT-regulating metabolite. phosphatidylethanolamine 101-103 IL2 inducible T cell kinase Homo sapiens 128-131 31695197-3 2019 Inhibition of mTORC1 induces a lipid signalling cascade via the phosphatidic acid phosphatase LIPIN1, which decreases phosphatidylethanolamine levels in mitochondrial membranes and promotes proteolysis. phosphatidylethanolamine 118-142 CREB regulated transcription coactivator 1 Mus musculus 14-20 31695197-3 2019 Inhibition of mTORC1 induces a lipid signalling cascade via the phosphatidic acid phosphatase LIPIN1, which decreases phosphatidylethanolamine levels in mitochondrial membranes and promotes proteolysis. phosphatidylethanolamine 118-142 lipin 1 Homo sapiens 94-100 31681760-6 2019 In particular, NSM2 ablation resulted in increase of lyso-phosphatidylcholine (LPC) and lyso-phosphatidylethanolamine (LPE) which both govern PM biophysical properties. phosphatidylethanolamine 88-117 sphingomyelin phosphodiesterase 3 Homo sapiens 15-19 31681760-6 2019 In particular, NSM2 ablation resulted in increase of lyso-phosphatidylcholine (LPC) and lyso-phosphatidylethanolamine (LPE) which both govern PM biophysical properties. phosphatidylethanolamine 119-122 sphingomyelin phosphodiesterase 3 Homo sapiens 15-19 31132336-5 2019 ATP13A2 overexpression increases the fluorescence intensity of the fluorescent analog phosphatidylethanolamine (NBD-PE) and the formation of multilamellar bodies, resembling the so-called "drug-induced phospholipidosis". phosphatidylethanolamine 86-110 ATPase cation transporting 13A2 Homo sapiens 0-7 31302248-1 2019 Yeast phosphatidylinositol transfer protein (PITP) Pdr17 is an essential component of the complex required for decarboxylation of phosphatidylserine (PS) to phosphatidylethanolamine (PE) at a non-mitochondrial location. phosphatidylethanolamine 157-181 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 51-56 31302248-1 2019 Yeast phosphatidylinositol transfer protein (PITP) Pdr17 is an essential component of the complex required for decarboxylation of phosphatidylserine (PS) to phosphatidylethanolamine (PE) at a non-mitochondrial location. phosphatidylethanolamine 183-185 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 51-56 31302248-3 2019 We generated a Pdr17E237A, K269A mutant protein to better understand the mechanism by which Pdr17p participates in the processes connected to the decarboxylation of PS to PE. phosphatidylethanolamine 171-173 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 92-98 31577958-3 2019 Here, by comprehensive metabolome analyses, we show that glutamine deprivation leads to phosphoethanolamine (PEtn) accumulation in cancer cells via the downregulation of PEtn cytidylyltransferase (PCYT2), a rate-limiting enzyme of phosphatidylethanolamine biosynthesis. phosphatidylethanolamine 231-255 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 197-202 31483742-10 2019 Furthermore, we show a positive genetic interaction of double deletion of MCP2 and PSD1, the gene encoding the enzyme that synthesizes the major amount of cellular phosphatidylethanolamine. phosphatidylethanolamine 164-188 Cqd2p Saccharomyces cerevisiae S288C 74-78 31483742-10 2019 Furthermore, we show a positive genetic interaction of double deletion of MCP2 and PSD1, the gene encoding the enzyme that synthesizes the major amount of cellular phosphatidylethanolamine. phosphatidylethanolamine 164-188 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 83-87 31515254-5 2019 In vitro binding studies show a strong association with GABARAP, and in amino-acid starved cells it preferentially interacts with lipidated LC3B, likely by binding to its PE moiety through its lipid-binding domain. phosphatidylethanolamine 171-173 gamma-aminobutyric acid receptor associated protein Mus musculus 56-63 31515254-5 2019 In vitro binding studies show a strong association with GABARAP, and in amino-acid starved cells it preferentially interacts with lipidated LC3B, likely by binding to its PE moiety through its lipid-binding domain. phosphatidylethanolamine 171-173 microtubule-associated protein 1 light chain 3 beta Mus musculus 140-144 32405618-2 2019 The absence of skeletal muscle phosphatidylethanolamine (PE) methyltransferase (PEMT) promotes an increase in skeletal muscle and whole-body metabolic rate to protect mice from diet-induced obesity. phosphatidylethanolamine 57-59 phosphatidylethanolamine N-methyltransferase Mus musculus 80-84 30958856-3 2019 Here we report that Sfh1, a member of Sec14 family proteins of S. cerevisiae, possesses the ability to enhance PE production by Psd2. phosphatidylethanolamine 111-113 Sfh1p Saccharomyces cerevisiae S288C 20-24 31051106-6 2019 We demonstrate that Mfn2 binds phosphatidylserine (PS) and can specifically extract PS into membrane domains, favoring PS transfer to mitochondria and mitochondrial phosphatidylethanolamine (PE) synthesis. phosphatidylethanolamine 165-189 mitofusin 2 Mus musculus 20-24 31051106-6 2019 We demonstrate that Mfn2 binds phosphatidylserine (PS) and can specifically extract PS into membrane domains, favoring PS transfer to mitochondria and mitochondrial phosphatidylethanolamine (PE) synthesis. phosphatidylethanolamine 191-193 mitofusin 2 Mus musculus 20-24 31315929-2 2019 The only currently known cellular molecules covalently modified by LC3/GABARAP are membrane phospholipids such as phosphatidylethanolamine in the autophagosome membrane. phosphatidylethanolamine 114-138 microtubule associated protein 1 light chain 3 alpha Homo sapiens 67-70 31315929-2 2019 The only currently known cellular molecules covalently modified by LC3/GABARAP are membrane phospholipids such as phosphatidylethanolamine in the autophagosome membrane. phosphatidylethanolamine 114-138 GABA type A receptor-associated protein Homo sapiens 71-78 31371510-6 2019 Using an electrophysiological method based on solid supported membranes, we observed the generation of a transient electrical current by the mammalian P4-ATPase ATP8A2 in the presence of ATP and the negatively charged lipid substrate phosphatidylserine, whereas only a diminutive current was generated with the lipid substrate phosphatidylethanolamine, which carries no or little charge under the conditions of the measurement. phosphatidylethanolamine 327-351 ATPase phospholipid transporting 8A2 Homo sapiens 161-167 31366014-6 2019 Phosphatidylethanolamine (PE) (18:0/16:1) was upregulated by furosine both in mice testicle tissue and in primary sertoli cells, meanwhile, PE(18:0/16:1) was proved to activate Cep55/NF-kappaB/PI3K/Akt/FOX01/TNF-alpha pathway, and as a functional protein in dairy products, lactoferrin could inhibit expression of this pathway when combined with furosine. phosphatidylethanolamine 0-24 centrosomal protein 55 Mus musculus 177-182 31366014-6 2019 Phosphatidylethanolamine (PE) (18:0/16:1) was upregulated by furosine both in mice testicle tissue and in primary sertoli cells, meanwhile, PE(18:0/16:1) was proved to activate Cep55/NF-kappaB/PI3K/Akt/FOX01/TNF-alpha pathway, and as a functional protein in dairy products, lactoferrin could inhibit expression of this pathway when combined with furosine. phosphatidylethanolamine 0-24 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 183-192 31366014-6 2019 Phosphatidylethanolamine (PE) (18:0/16:1) was upregulated by furosine both in mice testicle tissue and in primary sertoli cells, meanwhile, PE(18:0/16:1) was proved to activate Cep55/NF-kappaB/PI3K/Akt/FOX01/TNF-alpha pathway, and as a functional protein in dairy products, lactoferrin could inhibit expression of this pathway when combined with furosine. phosphatidylethanolamine 0-24 thymoma viral proto-oncogene 1 Mus musculus 198-201 31366014-6 2019 Phosphatidylethanolamine (PE) (18:0/16:1) was upregulated by furosine both in mice testicle tissue and in primary sertoli cells, meanwhile, PE(18:0/16:1) was proved to activate Cep55/NF-kappaB/PI3K/Akt/FOX01/TNF-alpha pathway, and as a functional protein in dairy products, lactoferrin could inhibit expression of this pathway when combined with furosine. phosphatidylethanolamine 0-24 tumor necrosis factor Mus musculus 208-217 31366014-6 2019 Phosphatidylethanolamine (PE) (18:0/16:1) was upregulated by furosine both in mice testicle tissue and in primary sertoli cells, meanwhile, PE(18:0/16:1) was proved to activate Cep55/NF-kappaB/PI3K/Akt/FOX01/TNF-alpha pathway, and as a functional protein in dairy products, lactoferrin could inhibit expression of this pathway when combined with furosine. phosphatidylethanolamine 0-24 lactotransferrin Mus musculus 274-285 31366014-6 2019 Phosphatidylethanolamine (PE) (18:0/16:1) was upregulated by furosine both in mice testicle tissue and in primary sertoli cells, meanwhile, PE(18:0/16:1) was proved to activate Cep55/NF-kappaB/PI3K/Akt/FOX01/TNF-alpha pathway, and as a functional protein in dairy products, lactoferrin could inhibit expression of this pathway when combined with furosine. phosphatidylethanolamine 26-28 centrosomal protein 55 Mus musculus 177-182 31366014-6 2019 Phosphatidylethanolamine (PE) (18:0/16:1) was upregulated by furosine both in mice testicle tissue and in primary sertoli cells, meanwhile, PE(18:0/16:1) was proved to activate Cep55/NF-kappaB/PI3K/Akt/FOX01/TNF-alpha pathway, and as a functional protein in dairy products, lactoferrin could inhibit expression of this pathway when combined with furosine. phosphatidylethanolamine 26-28 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 183-192 31366014-6 2019 Phosphatidylethanolamine (PE) (18:0/16:1) was upregulated by furosine both in mice testicle tissue and in primary sertoli cells, meanwhile, PE(18:0/16:1) was proved to activate Cep55/NF-kappaB/PI3K/Akt/FOX01/TNF-alpha pathway, and as a functional protein in dairy products, lactoferrin could inhibit expression of this pathway when combined with furosine. phosphatidylethanolamine 26-28 thymoma viral proto-oncogene 1 Mus musculus 198-201 31366014-6 2019 Phosphatidylethanolamine (PE) (18:0/16:1) was upregulated by furosine both in mice testicle tissue and in primary sertoli cells, meanwhile, PE(18:0/16:1) was proved to activate Cep55/NF-kappaB/PI3K/Akt/FOX01/TNF-alpha pathway, and as a functional protein in dairy products, lactoferrin could inhibit expression of this pathway when combined with furosine. phosphatidylethanolamine 26-28 tumor necrosis factor Mus musculus 208-217 31366014-6 2019 Phosphatidylethanolamine (PE) (18:0/16:1) was upregulated by furosine both in mice testicle tissue and in primary sertoli cells, meanwhile, PE(18:0/16:1) was proved to activate Cep55/NF-kappaB/PI3K/Akt/FOX01/TNF-alpha pathway, and as a functional protein in dairy products, lactoferrin could inhibit expression of this pathway when combined with furosine. phosphatidylethanolamine 26-28 lactotransferrin Mus musculus 274-285 31300716-3 2019 LC3-II, a standard marker for autophagosomes, is generated by the conjugation of cytosolic LC3-I to phosphatidylethanolamine (PE) on the surface of nascent autophagosomes. phosphatidylethanolamine 100-124 microtubule associated protein 1 light chain 3 alpha Homo sapiens 0-3 31300716-3 2019 LC3-II, a standard marker for autophagosomes, is generated by the conjugation of cytosolic LC3-I to phosphatidylethanolamine (PE) on the surface of nascent autophagosomes. phosphatidylethanolamine 126-128 microtubule associated protein 1 light chain 3 alpha Homo sapiens 0-3 31300716-3 2019 LC3-II, a standard marker for autophagosomes, is generated by the conjugation of cytosolic LC3-I to phosphatidylethanolamine (PE) on the surface of nascent autophagosomes. phosphatidylethanolamine 126-128 microtubule associated protein 1 light chain 3 alpha Homo sapiens 91-94 31243363-3 2019 Here we describe the cryo-electron microscopy structure of the P4-ATPase Drs2p-Cdc50p, a Saccharomyces cerevisiae lipid flippase that is specific to phosphatidylserine and phosphatidylethanolamine. phosphatidylethanolamine 172-196 aminophospholipid translocase regulatory protein CDC50 Saccharomyces cerevisiae S288C 79-85 30958856-3 2019 Here we report that Sfh1, a member of Sec14 family proteins of S. cerevisiae, possesses the ability to enhance PE production by Psd2. phosphatidylethanolamine 111-113 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 38-43 30958856-3 2019 Here we report that Sfh1, a member of Sec14 family proteins of S. cerevisiae, possesses the ability to enhance PE production by Psd2. phosphatidylethanolamine 111-113 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 128-132 30958856-4 2019 Overexpression of SFH1 in the strain defective in Psd1 restored its growth on non-fermentable carbon sources and increased the intracellular and mitochondrial PE levels. phosphatidylethanolamine 159-161 Sfh1p Saccharomyces cerevisiae S288C 18-22 30958856-4 2019 Overexpression of SFH1 in the strain defective in Psd1 restored its growth on non-fermentable carbon sources and increased the intracellular and mitochondrial PE levels. phosphatidylethanolamine 159-161 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 50-54 30509129-8 2019 Here, we discuss the cellular functions of phosphatidylcholine flippases and suggest a model for the phenotype of progressive familial intrahepatic cholestasis 1 caused by a defect in ATP8B1.-Shin, H.-W., Takatsu, H. Substrates of P4-ATPases: beyond aminophospholipids (phosphatidylserine and phosphatidylethanolamine). phosphatidylethanolamine 293-317 ATPase, class I, type 8B, member 1 Mus musculus 184-190 30658058-4 2019 Interestingly, HBx-induced membrane permeabilization was enhanced by liposomes containing phosphatidylethanolamine, which plays a crucial role in forming a negative curvature on the membrane. phosphatidylethanolamine 90-114 X protein Hepatitis B virus 15-18 30858161-1 2019 Exome sequencing of two sisters with congenital cataracts, short stature, and white matter changes identified compound heterozygous variants in the PISD gene, encoding the phosphatidylserine decarboxylase enzyme that converts phosphatidylserine to phosphatidylethanolamine (PE) in the inner mitochondrial membrane (IMM). phosphatidylethanolamine 248-272 phosphatidylserine decarboxylase Homo sapiens 148-152 30858161-1 2019 Exome sequencing of two sisters with congenital cataracts, short stature, and white matter changes identified compound heterozygous variants in the PISD gene, encoding the phosphatidylserine decarboxylase enzyme that converts phosphatidylserine to phosphatidylethanolamine (PE) in the inner mitochondrial membrane (IMM). phosphatidylethanolamine 248-272 phosphatidylserine decarboxylase Homo sapiens 172-204 30858161-1 2019 Exome sequencing of two sisters with congenital cataracts, short stature, and white matter changes identified compound heterozygous variants in the PISD gene, encoding the phosphatidylserine decarboxylase enzyme that converts phosphatidylserine to phosphatidylethanolamine (PE) in the inner mitochondrial membrane (IMM). phosphatidylethanolamine 274-276 phosphatidylserine decarboxylase Homo sapiens 148-152 30858161-1 2019 Exome sequencing of two sisters with congenital cataracts, short stature, and white matter changes identified compound heterozygous variants in the PISD gene, encoding the phosphatidylserine decarboxylase enzyme that converts phosphatidylserine to phosphatidylethanolamine (PE) in the inner mitochondrial membrane (IMM). phosphatidylethanolamine 274-276 phosphatidylserine decarboxylase Homo sapiens 172-204 30858161-2 2019 Decreased conversion of phosphatidylserine to PE in patient fibroblasts is consistent with impaired phosphatidylserine decarboxylase (PISD) enzyme activity. phosphatidylethanolamine 46-48 phosphatidylserine decarboxylase Homo sapiens 100-132 30858161-2 2019 Decreased conversion of phosphatidylserine to PE in patient fibroblasts is consistent with impaired phosphatidylserine decarboxylase (PISD) enzyme activity. phosphatidylethanolamine 46-48 phosphatidylserine decarboxylase Homo sapiens 134-138 31788037-3 2019 To examine the substrate utilization of PE and PC by PLA2, we developed a method to accurately detect and measure specific forms of PE and PC as low as 50 femtomoles. phosphatidylethanolamine 40-42 phospholipase A2 group IB Homo sapiens 53-57 31788037-3 2019 To examine the substrate utilization of PE and PC by PLA2, we developed a method to accurately detect and measure specific forms of PE and PC as low as 50 femtomoles. phosphatidylethanolamine 132-134 phospholipase A2 group IB Homo sapiens 53-57 31788037-4 2019 Validation of this method consisted of an enzymatic assay to monitor docosahexaenoic acid and arachidonic acid release from the hydrolysis of PE and PC by group IV phospholipase A2 (cPLA2alpha) coupled to the generation of lyso-PE (LPE) and lyso-PC (LPC). phosphatidylethanolamine 142-144 phospholipase A2 group IB Homo sapiens 164-180 31788037-4 2019 Validation of this method consisted of an enzymatic assay to monitor docosahexaenoic acid and arachidonic acid release from the hydrolysis of PE and PC by group IV phospholipase A2 (cPLA2alpha) coupled to the generation of lyso-PE (LPE) and lyso-PC (LPC). phosphatidylethanolamine 142-144 phospholipase A2 group IVA Homo sapiens 182-192 31788037-4 2019 Validation of this method consisted of an enzymatic assay to monitor docosahexaenoic acid and arachidonic acid release from the hydrolysis of PE and PC by group IV phospholipase A2 (cPLA2alpha) coupled to the generation of lyso-PE (LPE) and lyso-PC (LPC). phosphatidylethanolamine 228-230 phospholipase A2 group IB Homo sapiens 164-180 31788037-4 2019 Validation of this method consisted of an enzymatic assay to monitor docosahexaenoic acid and arachidonic acid release from the hydrolysis of PE and PC by group IV phospholipase A2 (cPLA2alpha) coupled to the generation of lyso-PE (LPE) and lyso-PC (LPC). phosphatidylethanolamine 228-230 phospholipase A2 group IVA Homo sapiens 182-192 31788037-6 2019 Finally, genetic validation for the specificity of the method consisted of the downregulation of two biosynthetic enzymes responsible for the production of PE and PC, choline kinase A (CHKA) and ethanolamine kinase 1 (ETNK1). phosphatidylethanolamine 156-158 choline kinase alpha Homo sapiens 185-189 31788037-6 2019 Finally, genetic validation for the specificity of the method consisted of the downregulation of two biosynthetic enzymes responsible for the production of PE and PC, choline kinase A (CHKA) and ethanolamine kinase 1 (ETNK1). phosphatidylethanolamine 156-158 ethanolamine kinase 1 Homo sapiens 218-223 31788037-7 2019 This new UPLC ESI-MS/MS method provides accurate and highly sensitive detection of PE and PC species containing AA and DHA allowing for the specific examination of the substrate utilization of these phospholipids by PLA2 in vitro and in cells. phosphatidylethanolamine 83-85 phospholipase A2 group IB Homo sapiens 216-220 30488656-8 2019 PISD encodes phosphatidylserine (PS) decarboxylase that is localized in the inner mitochondrial membrane and catalyzes the decarboxylation of PS to phosphatidylethanolamine (PE) in mammalian cells. phosphatidylethanolamine 148-172 phosphatidylserine decarboxylase Homo sapiens 0-4 30488656-8 2019 PISD encodes phosphatidylserine (PS) decarboxylase that is localized in the inner mitochondrial membrane and catalyzes the decarboxylation of PS to phosphatidylethanolamine (PE) in mammalian cells. phosphatidylethanolamine 174-176 phosphatidylserine decarboxylase Homo sapiens 0-4 30778222-1 2019 Covalent modification of LC3 and GABARAP proteins to phosphatidylethanolamine in the double-membrane phagophore is a key event in the early phase of macroautophagy, but can also occur on single-membrane structures. phosphatidylethanolamine 53-77 microtubule associated protein 1 light chain 3 alpha Homo sapiens 25-28 30531185-11 2019 Controlled cortical impact resulted in accumulation of oxidized phosphatidylethanolamine, increased expression of 15-lipoxygenase and acyl-CoA synthetase long-chain family member 4 (enzyme that generates substrate for the esterification of arachidonic/adrenic acid into phosphatidylethanolamine), and depletion of glutathione in the ipsilateral cortex. phosphatidylethanolamine 270-294 acyl-CoA synthetase long-chain family member 4 Mus musculus 134-180 30837829-11 2019 The ratio of arachidonic acid (omega-6 FA) to docosahexaenoic acid (omega-3 FA)-containing PE species was increased at early time points in the hippocampus of injured versus sham mice, and in PS1/APP mice there was a coincidental increase compared to wild type littermates at all time points. phosphatidylethanolamine 91-93 presenilin 1 Mus musculus 192-195 30559287-5 2019 Using surface plasmon resonance (SPR) spectroscopy, we demonstrated that KRAS and Raf-1 proto-oncogene Ser/Thr kinase (RAF1) domains interact with these membranes primarily through electrostatic interactions with negatively charged lipids reinforced by additional interactions involving phosphatidyl ethanolamine and cholesterol. phosphatidylethanolamine 287-312 KRAS proto-oncogene, GTPase Homo sapiens 73-77 30559287-5 2019 Using surface plasmon resonance (SPR) spectroscopy, we demonstrated that KRAS and Raf-1 proto-oncogene Ser/Thr kinase (RAF1) domains interact with these membranes primarily through electrostatic interactions with negatively charged lipids reinforced by additional interactions involving phosphatidyl ethanolamine and cholesterol. phosphatidylethanolamine 287-312 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 119-123 30792701-9 2019 In contrast to Saccharomyces cerevisiae, C. albicans was found to use one enzyme, Ept1, for the final enzymatic step (ethanolamine/cholinephosphotransferase) that generates both PE and PC. phosphatidylethanolamine 178-180 selenoprotein I Mus musculus 82-86 30923033-7 2019 Meanwhile, the mRNA and protein expression of autophagy-related key genes from colon tissues comprising autophagy-related 5 (ATG5), LC3-phosphatidylethanolamine conjugate (LC-3II), beclin-1, and B cell lymphoma 2 (bcl-2) was examined by quantitative reverse transcription polymerase chain reaction and Western blot. phosphatidylethanolamine 136-160 microtubule-associated protein 1 light chain 3 alpha Mus musculus 132-135 30810528-2 2019 Previous studies in yeast revealed that the autophagy-related E3 complex Atg12-Atg5-Atg16 is recruited to the PAS via Atg16 interaction with Atg21, which binds phosphatidylinositol 3-phosphate (PI3P) produced at the PAS, to stimulate conjugation of the ubiquitin-like protein Atg8 to phosphatidylethanolamine. phosphatidylethanolamine 284-308 Atg12p Saccharomyces cerevisiae S288C 73-78 30810528-2 2019 Previous studies in yeast revealed that the autophagy-related E3 complex Atg12-Atg5-Atg16 is recruited to the PAS via Atg16 interaction with Atg21, which binds phosphatidylinositol 3-phosphate (PI3P) produced at the PAS, to stimulate conjugation of the ubiquitin-like protein Atg8 to phosphatidylethanolamine. phosphatidylethanolamine 284-308 Atg5p Saccharomyces cerevisiae S288C 79-83 30810528-2 2019 Previous studies in yeast revealed that the autophagy-related E3 complex Atg12-Atg5-Atg16 is recruited to the PAS via Atg16 interaction with Atg21, which binds phosphatidylinositol 3-phosphate (PI3P) produced at the PAS, to stimulate conjugation of the ubiquitin-like protein Atg8 to phosphatidylethanolamine. phosphatidylethanolamine 284-308 Atg16p Saccharomyces cerevisiae S288C 84-89 30810528-2 2019 Previous studies in yeast revealed that the autophagy-related E3 complex Atg12-Atg5-Atg16 is recruited to the PAS via Atg16 interaction with Atg21, which binds phosphatidylinositol 3-phosphate (PI3P) produced at the PAS, to stimulate conjugation of the ubiquitin-like protein Atg8 to phosphatidylethanolamine. phosphatidylethanolamine 284-308 Atg16p Saccharomyces cerevisiae S288C 118-123 30810528-2 2019 Previous studies in yeast revealed that the autophagy-related E3 complex Atg12-Atg5-Atg16 is recruited to the PAS via Atg16 interaction with Atg21, which binds phosphatidylinositol 3-phosphate (PI3P) produced at the PAS, to stimulate conjugation of the ubiquitin-like protein Atg8 to phosphatidylethanolamine. phosphatidylethanolamine 284-308 Atg21p Saccharomyces cerevisiae S288C 141-146 30810528-2 2019 Previous studies in yeast revealed that the autophagy-related E3 complex Atg12-Atg5-Atg16 is recruited to the PAS via Atg16 interaction with Atg21, which binds phosphatidylinositol 3-phosphate (PI3P) produced at the PAS, to stimulate conjugation of the ubiquitin-like protein Atg8 to phosphatidylethanolamine. phosphatidylethanolamine 284-308 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 276-280 30778222-1 2019 Covalent modification of LC3 and GABARAP proteins to phosphatidylethanolamine in the double-membrane phagophore is a key event in the early phase of macroautophagy, but can also occur on single-membrane structures. phosphatidylethanolamine 53-77 GABA type A receptor-associated protein Homo sapiens 33-40 30778222-2 2019 In both cases this involves transfer of LC3/GABARAP from ATG3 to phosphatidylethanolamine at the target membrane. phosphatidylethanolamine 65-89 microtubule associated protein 1 light chain 3 alpha Homo sapiens 40-43 30778222-2 2019 In both cases this involves transfer of LC3/GABARAP from ATG3 to phosphatidylethanolamine at the target membrane. phosphatidylethanolamine 65-89 GABA type A receptor-associated protein Homo sapiens 44-51 30778222-2 2019 In both cases this involves transfer of LC3/GABARAP from ATG3 to phosphatidylethanolamine at the target membrane. phosphatidylethanolamine 65-89 autophagy related 3 Homo sapiens 57-61 30255656-1 2019 Phosphatidylethanolamine (PE)-binding protein 4 (PEBP4) is an antiapoptotic protein that is aberrantly expressed in various malignancies. phosphatidylethanolamine 0-24 phosphatidylethanolamine binding protein 4 Homo sapiens 49-54 30503495-5 2019 During autophagy, ATG7 activates the conjugation of LC3 (ATG8) with phosphatidylethanolamine (PE) and ATG12 with ATG5. phosphatidylethanolamine 68-92 autophagy related 7 Homo sapiens 18-22 30503495-5 2019 During autophagy, ATG7 activates the conjugation of LC3 (ATG8) with phosphatidylethanolamine (PE) and ATG12 with ATG5. phosphatidylethanolamine 68-92 microtubule associated protein 1 light chain 3 alpha Homo sapiens 52-55 30503495-5 2019 During autophagy, ATG7 activates the conjugation of LC3 (ATG8) with phosphatidylethanolamine (PE) and ATG12 with ATG5. phosphatidylethanolamine 68-92 GABA type A receptor associated protein like 1 Homo sapiens 57-61 30503495-5 2019 During autophagy, ATG7 activates the conjugation of LC3 (ATG8) with phosphatidylethanolamine (PE) and ATG12 with ATG5. phosphatidylethanolamine 94-96 autophagy related 7 Homo sapiens 18-22 30503495-5 2019 During autophagy, ATG7 activates the conjugation of LC3 (ATG8) with phosphatidylethanolamine (PE) and ATG12 with ATG5. phosphatidylethanolamine 94-96 microtubule associated protein 1 light chain 3 alpha Homo sapiens 52-55 30503495-5 2019 During autophagy, ATG7 activates the conjugation of LC3 (ATG8) with phosphatidylethanolamine (PE) and ATG12 with ATG5. phosphatidylethanolamine 94-96 GABA type A receptor associated protein like 1 Homo sapiens 57-61 30611309-3 2019 StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events. phosphatidylethanolamine 104-128 StAR related lipid transfer domain containing 10 Homo sapiens 0-38 30611309-3 2019 StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events. phosphatidylethanolamine 104-128 StAR related lipid transfer domain containing 10 Homo sapiens 40-47 30611309-3 2019 StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events. phosphatidylethanolamine 130-132 StAR related lipid transfer domain containing 10 Homo sapiens 0-38 30611309-3 2019 StAR-related lipid transfer protein 10 (STARD10) is a lipid transporter of phosphatidylcholine (PC) and phosphatidylethanolamine (PE); changes on membrane composition of PC and PE occur before the morphological tumorigenic events. phosphatidylethanolamine 130-132 StAR related lipid transfer domain containing 10 Homo sapiens 40-47 30510114-4 2019 Atg8 is anchored to the phagophore and autophagosome membranes thanks to a phosphatidylethanolamine tail. phosphatidylethanolamine 75-99 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 0-4 30300671-1 2019 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver. phosphatidylethanolamine 61-85 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 30300671-1 2019 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver. phosphatidylethanolamine 61-85 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 30300671-1 2019 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC), mainly in the liver. phosphatidylethanolamine 46-48 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 30910027-2 2019 However, in contrast to the yeast and mammalian autophagosomal membrane proteins Atg8 and LC3, lipidation of the C. elegans ortholog LGG-1 with phosphatidylethanolamine has rarely been investigated by western blotting. phosphatidylethanolamine 144-168 Protein lgg-1 Caenorhabditis elegans 133-138 30255656-1 2019 Phosphatidylethanolamine (PE)-binding protein 4 (PEBP4) is an antiapoptotic protein that is aberrantly expressed in various malignancies. phosphatidylethanolamine 26-28 phosphatidylethanolamine binding protein 4 Homo sapiens 49-54 30308051-1 2018 BACKGROUND: Plasmalogens are either phosphatidylcholine (PC P) or phosphatidylethanolamine (PE P) glycerophospholipids containing a vinyl ether moiety in sn-1-position and an esterified fatty acid in sn-2 position. phosphatidylethanolamine 66-90 prolyl endopeptidase Homo sapiens 92-96 30477200-7 2018 Reducing the ratio of PC to PE increased the binding of perilipin 2 to liposomes in an in vitro experiment. phosphatidylethanolamine 28-30 perilipin 2 Rattus norvegicus 56-67 30397118-2 2018 ABCA4 is a flippase in photoreceptor outer segments (OS) that translocates retinaldehyde conjugated to phosphatidylethanolamine across OS disc membranes. phosphatidylethanolamine 103-127 ATP-binding cassette, sub-family A (ABC1), member 4 Mus musculus 0-5 30237174-5 2018 Depletion of the porins Por1 and Por2 destabilized Ups1 and Ups2, decreased CL levels by ~90%, and caused loss of Ups2-dependent phosphatidylethanolamine synthesis, but did not affect Ups2-independent phosphatidylethanolamine synthesis in mitochondria. phosphatidylethanolamine 129-153 porin POR1 Saccharomyces cerevisiae S288C 24-28 30237174-5 2018 Depletion of the porins Por1 and Por2 destabilized Ups1 and Ups2, decreased CL levels by ~90%, and caused loss of Ups2-dependent phosphatidylethanolamine synthesis, but did not affect Ups2-independent phosphatidylethanolamine synthesis in mitochondria. phosphatidylethanolamine 129-153 putative porin POR2 Saccharomyces cerevisiae S288C 33-37 30237174-5 2018 Depletion of the porins Por1 and Por2 destabilized Ups1 and Ups2, decreased CL levels by ~90%, and caused loss of Ups2-dependent phosphatidylethanolamine synthesis, but did not affect Ups2-independent phosphatidylethanolamine synthesis in mitochondria. phosphatidylethanolamine 129-153 Ups2p Saccharomyces cerevisiae S288C 114-118 30237174-5 2018 Depletion of the porins Por1 and Por2 destabilized Ups1 and Ups2, decreased CL levels by ~90%, and caused loss of Ups2-dependent phosphatidylethanolamine synthesis, but did not affect Ups2-independent phosphatidylethanolamine synthesis in mitochondria. phosphatidylethanolamine 129-153 Ups2p Saccharomyces cerevisiae S288C 114-118 30237174-5 2018 Depletion of the porins Por1 and Por2 destabilized Ups1 and Ups2, decreased CL levels by ~90%, and caused loss of Ups2-dependent phosphatidylethanolamine synthesis, but did not affect Ups2-independent phosphatidylethanolamine synthesis in mitochondria. phosphatidylethanolamine 201-225 porin POR1 Saccharomyces cerevisiae S288C 24-28 30237174-5 2018 Depletion of the porins Por1 and Por2 destabilized Ups1 and Ups2, decreased CL levels by ~90%, and caused loss of Ups2-dependent phosphatidylethanolamine synthesis, but did not affect Ups2-independent phosphatidylethanolamine synthesis in mitochondria. phosphatidylethanolamine 201-225 putative porin POR2 Saccharomyces cerevisiae S288C 33-37 30284996-7 2018 After treatment with recombinant LF in both doses, the phospholipid composition of Walker-256 carcinosarcoma cells was changed (3-fold increase of phosphatidylethanolamine, 3.4-fold increase of phosphatidylcholine, and 1.8-fold increase of sphingomyelin, while the cardiolipin content decreased by 67%. phosphatidylethanolamine 147-171 lactotransferrin Rattus norvegicus 33-35 29454770-2 2018 BACKGROUND: During apoptosis, the cell membrane phospholipids-phosphatidylserine (PS) and phosphatidylethanolamine (PE) are exposed and can be targeted by Annexin-V and Duramycin, respectively, for in vivo imaging. phosphatidylethanolamine 90-114 annexin A5 Rattus norvegicus 155-164 29454770-2 2018 BACKGROUND: During apoptosis, the cell membrane phospholipids-phosphatidylserine (PS) and phosphatidylethanolamine (PE) are exposed and can be targeted by Annexin-V and Duramycin, respectively, for in vivo imaging. phosphatidylethanolamine 116-118 annexin A5 Rattus norvegicus 155-164 30137201-2 2018 Here, we demonstrated that anti-leprosy drug Clofazimine can bind to hRKIP with a significantly stronger affinity than the endogenous substrate phosphatidylethanolamine (PE) by using Biolayer interference technology. phosphatidylethanolamine 144-168 phosphatidylethanolamine binding protein 1 Homo sapiens 69-74 30281112-1 2018 Background: Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 73-97 phosphatidylethanolamine N-methyltransferase Mus musculus 12-56 30281112-1 2018 Background: Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 73-97 phosphatidylethanolamine N-methyltransferase Mus musculus 58-62 30030859-2 2018 Members of the FLOWERING LOCUS T (FT)-like clade of phosphatidylethanolamine-binding proteins induce this developmental process in numerous species by forming regulatory protein complexes with FD-like bZIP transcription factors. phosphatidylethanolamine 52-76 protein FLOWERING LOCUS T-like Nicotiana tabacum 15-32 30030859-2 2018 Members of the FLOWERING LOCUS T (FT)-like clade of phosphatidylethanolamine-binding proteins induce this developmental process in numerous species by forming regulatory protein complexes with FD-like bZIP transcription factors. phosphatidylethanolamine 52-76 protein FLOWERING LOCUS T-like Nicotiana tabacum 34-36 30228369-4 2018 Acot7 overexpression modified specific phosphatidylcholine and phosphatidylethanolamine species in tibialis muscle of chow rats to levels similar to those observed in control HFD muscle. phosphatidylethanolamine 63-87 acyl-CoA thioesterase 7 Rattus norvegicus 0-5 30208966-6 2018 We found that a mixture of phosphatidylethanolamine (PE) and synthetic nucleic acid polyA was sufficient for stable replication of hamster brain-derived SSLOW PrPSc in serial Protein Misfolding Cyclic Amplification (sPMCA) that uses hamster rPrP as a substrate. phosphatidylethanolamine 27-51 prion protein Rattus norvegicus 241-245 30208966-6 2018 We found that a mixture of phosphatidylethanolamine (PE) and synthetic nucleic acid polyA was sufficient for stable replication of hamster brain-derived SSLOW PrPSc in serial Protein Misfolding Cyclic Amplification (sPMCA) that uses hamster rPrP as a substrate. phosphatidylethanolamine 53-55 prion protein Rattus norvegicus 241-245 29949447-4 2018 Cells lacking Snx4 display a deficiency in starvation induced, nonselective autophagy that is severely exacerbated by ablation of mitochondrial phosphatidylethanolamine synthesis. phosphatidylethanolamine 144-168 Snx4p Saccharomyces cerevisiae S288C 14-18 29949447-7 2018 Autophagy and vacuole fusion are restored by increasing phosphatidylethanolamine biosynthesis via alternative pathways, indicating that retrograde sorting by the Snx4 family sorting nexins maintains glycerophospholipid homeostasis required for autophagy and fusion competence of the vacuole membrane. phosphatidylethanolamine 56-80 Snx4p Saccharomyces cerevisiae S288C 162-166 30108598-1 2018 Arabidopsis thaliana serine decarboxylase 1 (SDC1) catalyzes conversion of serine to ethanolamine, the first reaction step of phosphatidylcholine and phosphatidylethanolamine biosynthesis. phosphatidylethanolamine 150-174 Pyridoxal phosphate (PLP)-dependent transferases superfamily protein Arabidopsis thaliana 21-43 30108598-1 2018 Arabidopsis thaliana serine decarboxylase 1 (SDC1) catalyzes conversion of serine to ethanolamine, the first reaction step of phosphatidylcholine and phosphatidylethanolamine biosynthesis. phosphatidylethanolamine 150-174 Pyridoxal phosphate (PLP)-dependent transferases superfamily protein Arabidopsis thaliana 45-49 29540528-2 2018 Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides. phosphatidylethanolamine 111-113 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 14-21 29844165-7 2018 This pathway is required to maintain levels of GPL, especially phosphatidylethanolamine (PE), as shown by stable shRNA-mediated silencing of PEPCK-M in H23 lung cancer cells. phosphatidylethanolamine 63-87 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 141-148 29844165-7 2018 This pathway is required to maintain levels of GPL, especially phosphatidylethanolamine (PE), as shown by stable shRNA-mediated silencing of PEPCK-M in H23 lung cancer cells. phosphatidylethanolamine 89-91 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 141-148 29874576-5 2018 PI4KA inactivation disproportionally reduced phosphatidylserine, phosphatidylethanolamine, and sphingomyelin content in mutant nerves, with similar changes observed in SCs treated with a PI4KA inhibitor. phosphatidylethanolamine 65-89 phosphatidylinositol 4-kinase alpha Mus musculus 0-5 29540528-2 2018 Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides. phosphatidylethanolamine 85-109 Lem3p Saccharomyces cerevisiae S288C 8-13 29866908-9 2018 Expression of AtSDC in either mutant restores PE synthesis, even in the absence of exogenous ethanolamine. phosphatidylethanolamine 46-48 ascorbic acid mannose pathway regulator, putative (DUF295) Arabidopsis thaliana 14-19 29866908-12 2018 In addition, expression of AtSDC restores PS synthesis in the cho1DeltaDelta mutant, which may be due to causing PS decarboxylase to run backwards and convert PE to PS. phosphatidylethanolamine 159-161 ascorbic acid mannose pathway regulator, putative (DUF295) Arabidopsis thaliana 27-32 30018401-9 2018 We also show that ATP11A, ATP11B and ATP11C, like ATP8A1 and ATP8A2, selectively flip phosphatidylserine and phosphatidylethanolamine across membranes. phosphatidylethanolamine 109-133 ATPase, class VI, type 11A Mus musculus 18-24 30018401-9 2018 We also show that ATP11A, ATP11B and ATP11C, like ATP8A1 and ATP8A2, selectively flip phosphatidylserine and phosphatidylethanolamine across membranes. phosphatidylethanolamine 109-133 ATPase, class VI, type 11B Mus musculus 26-32 30018401-9 2018 We also show that ATP11A, ATP11B and ATP11C, like ATP8A1 and ATP8A2, selectively flip phosphatidylserine and phosphatidylethanolamine across membranes. phosphatidylethanolamine 109-133 ATPase, class VI, type 11C Mus musculus 37-43 30018401-9 2018 We also show that ATP11A, ATP11B and ATP11C, like ATP8A1 and ATP8A2, selectively flip phosphatidylserine and phosphatidylethanolamine across membranes. phosphatidylethanolamine 109-133 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 Mus musculus 50-56 30018401-9 2018 We also show that ATP11A, ATP11B and ATP11C, like ATP8A1 and ATP8A2, selectively flip phosphatidylserine and phosphatidylethanolamine across membranes. phosphatidylethanolamine 109-133 ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 Mus musculus 61-67 29419481-0 2018 Noninvasive Whole-Body Imaging of Phosphatidylethanolamine as a Cell Death Marker Using 99mTc-Duramycin During TNF-Induced SIRS. phosphatidylethanolamine 34-58 tumor necrosis factor Mus musculus 111-114 29655284-8 2018 In vitro enzyme assays showed that NPC2 and NPC6 hydrolyze phosphatidylcholine and phosphatidylethanolamine, but not phosphatidate, being consistent with the reported substrate selectivity of NPCs. phosphatidylethanolamine 83-107 non-specific phospholipase C2 Arabidopsis thaliana 35-39 29655284-8 2018 In vitro enzyme assays showed that NPC2 and NPC6 hydrolyze phosphatidylcholine and phosphatidylethanolamine, but not phosphatidate, being consistent with the reported substrate selectivity of NPCs. phosphatidylethanolamine 83-107 non-specific phospholipase C6 Arabidopsis thaliana 44-48 29540528-2 2018 Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides. phosphatidylethanolamine 85-109 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 14-21 29540528-2 2018 Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides. phosphatidylethanolamine 111-113 Lem3p Saccharomyces cerevisiae S288C 8-13 29540528-2 2018 Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides. phosphatidylethanolamine 180-182 Lem3p Saccharomyces cerevisiae S288C 8-13 29540528-2 2018 Loss of Lem3p-Dnf1/2p flippases leads to the exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE) on the cell surface in yeast, resulting in sensitivity to PS- or PE-binding peptides. phosphatidylethanolamine 180-182 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 14-21 29342507-6 2018 RESULTS: HLA-B27-expressing macrophages showed phosphatidylethanolamine-conjugated microtubule-associated protein 1 light chain 3B levels similar to those in both control groups, before and after manipulation of autophagy. phosphatidylethanolamine 47-71 major histocompatibility complex, class I, B Homo sapiens 9-16 29695812-0 2018 Skeletal muscle phosphatidylcholine and phosphatidylethanolamine respond to exercise and influence insulin sensitivity in men. phosphatidylethanolamine 40-64 insulin Homo sapiens 99-106 29695812-1 2018 Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) composition in skeletal muscle have been linked to insulin sensitivity. phosphatidylethanolamine 29-53 insulin Homo sapiens 110-117 29695812-1 2018 Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) composition in skeletal muscle have been linked to insulin sensitivity. phosphatidylethanolamine 55-57 insulin Homo sapiens 110-117 29849891-3 2018 Methods: To measure autophagic activity in vivo, we quantified the abundance of the autophagy conjugates LC3-PE (phosphatidylethanolamine) and ATG12-ATG5 in tissue extracts of SGK1 wild-type (Sgk1+/+) and knockout (Sgk1-/-) mice that were either fed or starved for 24 h prior sacrifice. phosphatidylethanolamine 113-137 microtubule-associated protein 1 light chain 3 alpha Mus musculus 105-108 29849891-3 2018 Methods: To measure autophagic activity in vivo, we quantified the abundance of the autophagy conjugates LC3-PE (phosphatidylethanolamine) and ATG12-ATG5 in tissue extracts of SGK1 wild-type (Sgk1+/+) and knockout (Sgk1-/-) mice that were either fed or starved for 24 h prior sacrifice. phosphatidylethanolamine 113-137 serum/glucocorticoid regulated kinase 1 Mus musculus 176-180 28890071-7 2017 Chitotriosidase activity was similar across the genetic groups, while the levels of key lipids were altered in GBA mutation carriers: Monohexosylceramide, Ceramide and Sphingomyelin were elevated; while Phosphatidic acid (PA), Phosphatidylethanolamine (PE), Plasmalogen phosphatidylethanolamine (PEp) and Acyl Phosphatidylglycerol (AcylPG) were decreased. phosphatidylethanolamine 227-251 glucosylceramidase beta Homo sapiens 111-114 29367422-4 2018 We previously showed that TAT-5 phospholipid flippase activity maintains the asymmetric localization of the lipid phosphatidylethanolamine (PE) in the plasma membrane and inhibits EV budding by ectocytosis in Caenorhabditis elegans However, no proteins that inhibit ectocytosis upstream of TAT-5 were known. phosphatidylethanolamine 114-138 Phospholipid-transporting ATPase;putative phospholipid-transporting ATPase tat-5 Caenorhabditis elegans 26-31 29367422-4 2018 We previously showed that TAT-5 phospholipid flippase activity maintains the asymmetric localization of the lipid phosphatidylethanolamine (PE) in the plasma membrane and inhibits EV budding by ectocytosis in Caenorhabditis elegans However, no proteins that inhibit ectocytosis upstream of TAT-5 were known. phosphatidylethanolamine 140-142 Phospholipid-transporting ATPase;putative phospholipid-transporting ATPase tat-5 Caenorhabditis elegans 26-31 29367422-4 2018 We previously showed that TAT-5 phospholipid flippase activity maintains the asymmetric localization of the lipid phosphatidylethanolamine (PE) in the plasma membrane and inhibits EV budding by ectocytosis in Caenorhabditis elegans However, no proteins that inhibit ectocytosis upstream of TAT-5 were known. phosphatidylethanolamine 140-142 Phospholipid-transporting ATPase;putative phospholipid-transporting ATPase tat-5 Caenorhabditis elegans 290-295 29237558-1 2018 Atg8 is a unique ubiquitin-like protein that is covalently conjugated with a phosphatidylethanolamine through reactions similar to ubiquitination and plays essential roles in autophagy. phosphatidylethanolamine 77-101 GABA type A receptor associated protein like 1 Homo sapiens 0-4 29032301-6 2018 By treating PC vesicles with PLD in the presence of 1.7M serine and 0.3M ethanolamine, we obtained asymmetric vesicles that are topologically similar to intracellular vesicles containing phosphatidylserine and phosphatidylethanolamine in the cytosolic leaflet. phosphatidylethanolamine 210-234 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 29-32 29126902-1 2018 Phosphatidylserine decarboxylase 1 (Psd1p) catalyzes the formation of the majority of phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae. phosphatidylethanolamine 86-110 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 0-34 29126902-1 2018 Phosphatidylserine decarboxylase 1 (Psd1p) catalyzes the formation of the majority of phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae. phosphatidylethanolamine 86-110 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 36-41 29126902-1 2018 Phosphatidylserine decarboxylase 1 (Psd1p) catalyzes the formation of the majority of phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae. phosphatidylethanolamine 112-114 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 0-34 29126902-1 2018 Phosphatidylserine decarboxylase 1 (Psd1p) catalyzes the formation of the majority of phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae. phosphatidylethanolamine 112-114 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 36-41 29284664-4 2018 In the present study, we identified lysophosphatidic acid acyltransferase (LPAAT)3 as an enzyme that was upregulated in myoblasts during in vitro differentiation and selectively incorporated DHA into PC and PE. phosphatidylethanolamine 207-209 membrane bound O-acyltransferase domain containing 2 Homo sapiens 36-73 29284664-4 2018 In the present study, we identified lysophosphatidic acid acyltransferase (LPAAT)3 as an enzyme that was upregulated in myoblasts during in vitro differentiation and selectively incorporated DHA into PC and PE. phosphatidylethanolamine 207-209 1-acylglycerol-3-phosphate O-acyltransferase 3 Homo sapiens 75-82 29311554-5 2018 This interaction becomes transient upon activation of Atg3 and Atg7 due to transfer of LC3 to phosphatidylethanolamine (lipidation), a process crucial for functional autophagy. phosphatidylethanolamine 94-118 autophagy related 3 Mus musculus 54-58 29311554-5 2018 This interaction becomes transient upon activation of Atg3 and Atg7 due to transfer of LC3 to phosphatidylethanolamine (lipidation), a process crucial for functional autophagy. phosphatidylethanolamine 94-118 autophagy related 7 Mus musculus 63-67 29311554-5 2018 This interaction becomes transient upon activation of Atg3 and Atg7 due to transfer of LC3 to phosphatidylethanolamine (lipidation), a process crucial for functional autophagy. phosphatidylethanolamine 94-118 microtubule-associated protein 1 light chain 3 alpha Mus musculus 87-90 29746182-3 2018 During active autophagy, LC3 is transferred from the catalytic thiol of ATG7 to the active site thiol of ATG3, where it is conjugated to phosphatidylethanolamine. phosphatidylethanolamine 137-161 microtubule-associated protein 1 light chain 3 alpha Mus musculus 25-28 29746182-3 2018 During active autophagy, LC3 is transferred from the catalytic thiol of ATG7 to the active site thiol of ATG3, where it is conjugated to phosphatidylethanolamine. phosphatidylethanolamine 137-161 autophagy related 3 Mus musculus 105-109 29123098-1 2017 We and others showed that ATP11A and ATP11C, members of the P4-ATPase family, translocate phosphatidylserine (PS) and phosphatidylethanolamine from the exoplasmic to the cytoplasmic leaflets at the plasma membrane. phosphatidylethanolamine 118-142 ATPase phospholipid transporting 11A Homo sapiens 26-32 29123098-1 2017 We and others showed that ATP11A and ATP11C, members of the P4-ATPase family, translocate phosphatidylserine (PS) and phosphatidylethanolamine from the exoplasmic to the cytoplasmic leaflets at the plasma membrane. phosphatidylethanolamine 118-142 ATPase phospholipid transporting 11C Homo sapiens 37-43 29078410-8 2017 The Mdm12-Mmm1 complex binds all glycerophospholipids except for phosphatidylethanolamine (PE) in vitro. phosphatidylethanolamine 65-89 ERMES complex subunit MDM12 Saccharomyces cerevisiae S288C 4-9 29078410-8 2017 The Mdm12-Mmm1 complex binds all glycerophospholipids except for phosphatidylethanolamine (PE) in vitro. phosphatidylethanolamine 65-89 ERMES complex subunit MMM1 Saccharomyces cerevisiae S288C 10-14 29078410-8 2017 The Mdm12-Mmm1 complex binds all glycerophospholipids except for phosphatidylethanolamine (PE) in vitro. phosphatidylethanolamine 91-93 ERMES complex subunit MDM12 Saccharomyces cerevisiae S288C 4-9 29078410-8 2017 The Mdm12-Mmm1 complex binds all glycerophospholipids except for phosphatidylethanolamine (PE) in vitro. phosphatidylethanolamine 91-93 ERMES complex subunit MMM1 Saccharomyces cerevisiae S288C 10-14 28812137-5 2017 We found that increases in levels of fatty acid oxides such as stearic, oleic, linoleic, and arachidonic acid and decreases in levels of plasmalogens and phosphatidylethanolamine in the blood were associated with high Mb level. phosphatidylethanolamine 154-178 myoglobin Homo sapiens 218-220 28736247-8 2017 IL-1beta increased the biosynthesis of both phosphatidylethanolamine (PE) and PE-based plasmalogens. phosphatidylethanolamine 44-68 interleukin 1 beta Homo sapiens 0-8 28736247-8 2017 IL-1beta increased the biosynthesis of both phosphatidylethanolamine (PE) and PE-based plasmalogens. phosphatidylethanolamine 70-72 interleukin 1 beta Homo sapiens 0-8 28736247-8 2017 IL-1beta increased the biosynthesis of both phosphatidylethanolamine (PE) and PE-based plasmalogens. phosphatidylethanolamine 78-80 interleukin 1 beta Homo sapiens 0-8 29365132-2 2018 Autophagosome formation requires two ubiquitin-like systems conjugating Atg12 with Atg5, and Atg8 with lipid phosphatidylethanolamine (PE), respectively. phosphatidylethanolamine 135-137 SAC domain-containing protein 8 Arabidopsis thaliana 83-87 29290583-3 2018 The basis of the ER-mitochondrial PC synthesis pathway is the exclusive mitochondrial localization of a key pathway enzyme, phosphatidylserine decarboxylase Psd1, which generates phosphatidylethanolamine (PE). phosphatidylethanolamine 179-203 pleckstrin and Sec7 domain containing Homo sapiens 157-161 29290583-3 2018 The basis of the ER-mitochondrial PC synthesis pathway is the exclusive mitochondrial localization of a key pathway enzyme, phosphatidylserine decarboxylase Psd1, which generates phosphatidylethanolamine (PE). phosphatidylethanolamine 205-207 pleckstrin and Sec7 domain containing Homo sapiens 157-161 29435160-4 2018 The results indicated that triglycerides and phosphatidylcholines contributed significantly to altered hepatic lipids, whereas triglycerides and phosphatidylethanolamine-based plasmalogens (PEp) contributed most to altered serum lipids. phosphatidylethanolamine 145-169 prolyl endopeptidase Homo sapiens 190-193 29180659-4 2017 However, the CL accumulation in ups1 cells is enhanced by the depletion of Ups2, which forms a protein complex with Mdm35 and mediates phosphatidylserine (PS) transfer from the MOM to the MIM for phosphatidylethanolamine (PE) synthesis by a PS decarboxylase, Psd1. phosphatidylethanolamine 197-221 Ups1p Saccharomyces cerevisiae S288C 32-36 29180659-4 2017 However, the CL accumulation in ups1 cells is enhanced by the depletion of Ups2, which forms a protein complex with Mdm35 and mediates phosphatidylserine (PS) transfer from the MOM to the MIM for phosphatidylethanolamine (PE) synthesis by a PS decarboxylase, Psd1. phosphatidylethanolamine 197-221 Mdm35p Saccharomyces cerevisiae S288C 117-122 29180659-4 2017 However, the CL accumulation in ups1 cells is enhanced by the depletion of Ups2, which forms a protein complex with Mdm35 and mediates phosphatidylserine (PS) transfer from the MOM to the MIM for phosphatidylethanolamine (PE) synthesis by a PS decarboxylase, Psd1. phosphatidylethanolamine 223-225 Ups1p Saccharomyces cerevisiae S288C 32-36 29180659-4 2017 However, the CL accumulation in ups1 cells is enhanced by the depletion of Ups2, which forms a protein complex with Mdm35 and mediates phosphatidylserine (PS) transfer from the MOM to the MIM for phosphatidylethanolamine (PE) synthesis by a PS decarboxylase, Psd1. phosphatidylethanolamine 223-225 Mdm35p Saccharomyces cerevisiae S288C 117-122 29180659-5 2017 In this study, we found that the accumulation of CL in ups1 cells was enhanced by deletion of not only UPS2, but also PSD1 and CHO1 encoding a PS synthase, suggesting that low PE levels in mitochondria were relevant to the enhancement of CL accumulation in ups1 cells. phosphatidylethanolamine 177-179 Ups1p Saccharomyces cerevisiae S288C 55-59 29180659-8 2017 Thus, when the mitochondrial PE level is reduced, Fmp30, Mdm31, and Mdm32 seem to function cooperatively for the accumulation of CL in a UPS1-independent manner. phosphatidylethanolamine 29-31 N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D Saccharomyces cerevisiae S288C 50-55 29180659-8 2017 Thus, when the mitochondrial PE level is reduced, Fmp30, Mdm31, and Mdm32 seem to function cooperatively for the accumulation of CL in a UPS1-independent manner. phosphatidylethanolamine 29-31 Mdm31p Saccharomyces cerevisiae S288C 57-62 29180659-8 2017 Thus, when the mitochondrial PE level is reduced, Fmp30, Mdm31, and Mdm32 seem to function cooperatively for the accumulation of CL in a UPS1-independent manner. phosphatidylethanolamine 29-31 Mdm32p Saccharomyces cerevisiae S288C 68-73 29180659-8 2017 Thus, when the mitochondrial PE level is reduced, Fmp30, Mdm31, and Mdm32 seem to function cooperatively for the accumulation of CL in a UPS1-independent manner. phosphatidylethanolamine 29-31 Ups1p Saccharomyces cerevisiae S288C 137-141 29141586-13 2017 During gamma-ray-induced membrane injury, the degradation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) may be mediated by PLDzeta1 or phospholipase A1. phosphatidylethanolamine 90-114 phospholipase D P1 Arabidopsis thaliana 139-147 29141586-13 2017 During gamma-ray-induced membrane injury, the degradation of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) may be mediated by PLDzeta1 or phospholipase A1. phosphatidylethanolamine 116-118 phospholipase D P1 Arabidopsis thaliana 139-147 28890071-7 2017 Chitotriosidase activity was similar across the genetic groups, while the levels of key lipids were altered in GBA mutation carriers: Monohexosylceramide, Ceramide and Sphingomyelin were elevated; while Phosphatidic acid (PA), Phosphatidylethanolamine (PE), Plasmalogen phosphatidylethanolamine (PEp) and Acyl Phosphatidylglycerol (AcylPG) were decreased. phosphatidylethanolamine 253-255 glucosylceramidase beta Homo sapiens 111-114 28807933-1 2017 We previously characterized LPAATdelta/AGPAT4 as a mitochondrial lysophosphatidic acid acyltransferase that regulates brain levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). phosphatidylethanolamine 160-184 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Mus musculus 28-38 28807933-1 2017 We previously characterized LPAATdelta/AGPAT4 as a mitochondrial lysophosphatidic acid acyltransferase that regulates brain levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). phosphatidylethanolamine 160-184 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Mus musculus 39-45 28807933-1 2017 We previously characterized LPAATdelta/AGPAT4 as a mitochondrial lysophosphatidic acid acyltransferase that regulates brain levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). phosphatidylethanolamine 186-188 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Mus musculus 28-38 28807933-1 2017 We previously characterized LPAATdelta/AGPAT4 as a mitochondrial lysophosphatidic acid acyltransferase that regulates brain levels of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI). phosphatidylethanolamine 186-188 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Mus musculus 39-45 29054999-4 2017 The spectrum of self-antigens captured by CD1b skews toward abundant membrane phospholipids such as phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 124-148 CD1b molecule Homo sapiens 42-46 28855256-8 2017 The other mammalian pathway for PC biosynthesis is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT) that converts phosphatidylethanolamine to PC. phosphatidylethanolamine 64-88 phosphatidylethanolamine N-methyltransferase Homo sapiens 110-114 28583805-3 2017 Lipidated Atg8/LC3 proteins that are conjugated to phosphatidylethanolamine (PE) play a key role in autophagosome biogenesis. phosphatidylethanolamine 77-79 GABA type A receptor associated protein like 1 Homo sapiens 10-14 29142222-3 2017 In this work we have performed a biophysical study of human ATG3 interaction with membranes containing phosphatidylethanolamine, phosphatidylcholine and anionic phospholipids. phosphatidylethanolamine 103-127 autophagy related 3 Homo sapiens 60-64 28432553-3 2017 PE is physiologically linked with triacylglycerol (TAG) metabolism in Saccharomyces cerevisiae, involving an acyl-CoA-independent pathway through the phospholipid:diacylglycerol acyltransferase activity of the Lro1 protein. phosphatidylethanolamine 0-2 phospholipid:diacylglycerol acyltransferase Saccharomyces cerevisiae S288C 210-214 28583805-3 2017 Lipidated Atg8/LC3 proteins that are conjugated to phosphatidylethanolamine (PE) play a key role in autophagosome biogenesis. phosphatidylethanolamine 77-79 microtubule associated protein 1 light chain 3 alpha Homo sapiens 15-18 28583805-5 2017 Herein, we report the semisynthesis of LC3 proteins and mutants with modifications of different PE fragments or lipids using native chemical ligation and aminolysis approaches. phosphatidylethanolamine 96-98 microtubule associated protein 1 light chain 3 alpha Homo sapiens 39-42 28434889-3 2017 Knock-down of TM6SF2 resulted in intracellular accumulation of TAGs, cholesterol esters, phosphatidylcholine (PC) and phosphatidylethanolamine. phosphatidylethanolamine 118-142 transmembrane 6 superfamily member 2 Homo sapiens 14-20 28583805-3 2017 Lipidated Atg8/LC3 proteins that are conjugated to phosphatidylethanolamine (PE) play a key role in autophagosome biogenesis. phosphatidylethanolamine 51-75 GABA type A receptor associated protein like 1 Homo sapiens 10-14 28583805-3 2017 Lipidated Atg8/LC3 proteins that are conjugated to phosphatidylethanolamine (PE) play a key role in autophagosome biogenesis. phosphatidylethanolamine 51-75 microtubule associated protein 1 light chain 3 alpha Homo sapiens 15-18 28971069-4 2017 The Legionella effector protein RavZ interferes with autophagy by irreversibly deconjugating LC3, an autophagy-related ubiquitin-like protein, from a phosphoglycolipid phosphatidylethanolamine. phosphatidylethanolamine 168-192 microtubule associated protein 1 light chain 3 alpha Homo sapiens 93-96 28821708-1 2017 Upon induction of autophagy, the ubiquitin-like protein LC3 is conjugated to phosphatidylethanolamine (PE) on the inner and outer membrane of autophagosomes to allow cargo selection and autophagosome formation. phosphatidylethanolamine 77-101 microtubule associated protein 1 light chain 3 alpha Homo sapiens 56-59 28821708-1 2017 Upon induction of autophagy, the ubiquitin-like protein LC3 is conjugated to phosphatidylethanolamine (PE) on the inner and outer membrane of autophagosomes to allow cargo selection and autophagosome formation. phosphatidylethanolamine 103-105 microtubule associated protein 1 light chain 3 alpha Homo sapiens 56-59 28821724-1 2017 The biogenesis of autophagosomes depends on the conjugation of Atg8-like proteins with phosphatidylethanolamine. phosphatidylethanolamine 87-111 GABA type A receptor associated protein like 1 Homo sapiens 63-67 28821724-2 2017 Atg8 processing by the cysteine protease Atg4 is required for its covalent linkage to phosphatidylethanolamine, but it is also necessary for Atg8 deconjugation from this lipid to release it from membranes. phosphatidylethanolamine 86-110 GABA type A receptor associated protein like 1 Homo sapiens 0-4 28821724-5 2017 These results are consistent with a model where the Atg8-phosphatidylethanolamine pool essential for autophagosome formation is protected at least in part by Atg4 phosphorylation by Atg1 while newly synthesized cytoplasmic Atg8 remains susceptible to constitutive Atg4 processing.The protease Atg4 mediates Atg8 lipidation, required for autophagosome biogenesis, but also triggers Atg8 release from the membranes, however is unclear how these steps are coordinated. phosphatidylethanolamine 57-81 GABA type A receptor associated protein like 1 Homo sapiens 52-56 28821724-5 2017 These results are consistent with a model where the Atg8-phosphatidylethanolamine pool essential for autophagosome formation is protected at least in part by Atg4 phosphorylation by Atg1 while newly synthesized cytoplasmic Atg8 remains susceptible to constitutive Atg4 processing.The protease Atg4 mediates Atg8 lipidation, required for autophagosome biogenesis, but also triggers Atg8 release from the membranes, however is unclear how these steps are coordinated. phosphatidylethanolamine 57-81 unc-51 like autophagy activating kinase 1 Homo sapiens 182-186 28740220-4 2017 Here, we demonstrate that insulin temporally induces Tnfaip8, which mediates the anti-autophagic action of insulin through formation of a novel ternary complex including Tnfaip8, phosphatidylethanolamine (PE) and Galphai3. phosphatidylethanolamine 179-203 insulin Homo sapiens 26-33 28740220-4 2017 Here, we demonstrate that insulin temporally induces Tnfaip8, which mediates the anti-autophagic action of insulin through formation of a novel ternary complex including Tnfaip8, phosphatidylethanolamine (PE) and Galphai3. phosphatidylethanolamine 179-203 TNF alpha induced protein 8 Homo sapiens 53-60 28740220-4 2017 Here, we demonstrate that insulin temporally induces Tnfaip8, which mediates the anti-autophagic action of insulin through formation of a novel ternary complex including Tnfaip8, phosphatidylethanolamine (PE) and Galphai3. phosphatidylethanolamine 179-203 insulin Homo sapiens 107-114 28740220-4 2017 Here, we demonstrate that insulin temporally induces Tnfaip8, which mediates the anti-autophagic action of insulin through formation of a novel ternary complex including Tnfaip8, phosphatidylethanolamine (PE) and Galphai3. phosphatidylethanolamine 205-207 insulin Homo sapiens 26-33 28740220-4 2017 Here, we demonstrate that insulin temporally induces Tnfaip8, which mediates the anti-autophagic action of insulin through formation of a novel ternary complex including Tnfaip8, phosphatidylethanolamine (PE) and Galphai3. phosphatidylethanolamine 205-207 TNF alpha induced protein 8 Homo sapiens 53-60 28740220-4 2017 Here, we demonstrate that insulin temporally induces Tnfaip8, which mediates the anti-autophagic action of insulin through formation of a novel ternary complex including Tnfaip8, phosphatidylethanolamine (PE) and Galphai3. phosphatidylethanolamine 205-207 insulin Homo sapiens 107-114 28704456-4 2017 In S. cerevisiae, the ubiquitin-like protein Atg8 is C-terminally conjugated to the phospholipid phosphatidylethanolamine (PE) to generate Atg8-PE. phosphatidylethanolamine 97-121 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 45-49 28704456-4 2017 In S. cerevisiae, the ubiquitin-like protein Atg8 is C-terminally conjugated to the phospholipid phosphatidylethanolamine (PE) to generate Atg8-PE. phosphatidylethanolamine 97-121 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 139-143 28704456-4 2017 In S. cerevisiae, the ubiquitin-like protein Atg8 is C-terminally conjugated to the phospholipid phosphatidylethanolamine (PE) to generate Atg8-PE. phosphatidylethanolamine 123-125 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 45-49 28704456-4 2017 In S. cerevisiae, the ubiquitin-like protein Atg8 is C-terminally conjugated to the phospholipid phosphatidylethanolamine (PE) to generate Atg8-PE. phosphatidylethanolamine 123-125 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 139-143 28373057-7 2017 Liquid chromatography-tandem mass spectrometry analyses revealed that the two proteins had different preferences for phospholipid export: ABCA7 preferred phosphatidylcholine (PC)>=lysoPC>sphingomyelin (SM)=phosphatidylethanolamine (PE), whereas ABCA1 preferred PC>>SM>PE=lysoPC. phosphatidylethanolamine 206-230 LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7 Mesocricetus auratus 138-143 28373057-7 2017 Liquid chromatography-tandem mass spectrometry analyses revealed that the two proteins had different preferences for phospholipid export: ABCA7 preferred phosphatidylcholine (PC)>=lysoPC>sphingomyelin (SM)=phosphatidylethanolamine (PE), whereas ABCA1 preferred PC>>SM>PE=lysoPC. phosphatidylethanolamine 232-234 LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7 Mesocricetus auratus 138-143 28373057-7 2017 Liquid chromatography-tandem mass spectrometry analyses revealed that the two proteins had different preferences for phospholipid export: ABCA7 preferred phosphatidylcholine (PC)>=lysoPC>sphingomyelin (SM)=phosphatidylethanolamine (PE), whereas ABCA1 preferred PC>>SM>PE=lysoPC. phosphatidylethanolamine 268-270 LOW QUALITY PROTEIN: phospholipid-transporting ATPase ABCA7 Mesocricetus auratus 138-143 28473294-1 2017 In the yeast Saccharomyces cerevisiae, the mitochondrial phosphatidylserine decarboxylase 1 (Psd1p) produces the largest amount of cellular phosphatidylethanolamine (PE). phosphatidylethanolamine 140-164 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 57-91 28473294-1 2017 In the yeast Saccharomyces cerevisiae, the mitochondrial phosphatidylserine decarboxylase 1 (Psd1p) produces the largest amount of cellular phosphatidylethanolamine (PE). phosphatidylethanolamine 140-164 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 93-98 28473294-1 2017 In the yeast Saccharomyces cerevisiae, the mitochondrial phosphatidylserine decarboxylase 1 (Psd1p) produces the largest amount of cellular phosphatidylethanolamine (PE). phosphatidylethanolamine 166-168 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 57-91 28815570-0 2017 Tat transport in Escherichia coli requires zwitterionic phosphatidylethanolamine but no specific negatively charged phospholipid. phosphatidylethanolamine 56-80 twin-arginine translocation (TAT) pathway signal sequence domain protein Escherichia coli 0-3 28815570-1 2017 Translocation of folded proteins by the Tat system of Escherichia coli is believed to rely on the presence of phosphatidylethanolamine (PE) and the negatively charged phospholipids cardiolipin (CL) and phosphatidylglycerol (PG). phosphatidylethanolamine 110-134 twin-arginine translocation (TAT) pathway signal sequence domain protein Escherichia coli 40-43 28815570-1 2017 Translocation of folded proteins by the Tat system of Escherichia coli is believed to rely on the presence of phosphatidylethanolamine (PE) and the negatively charged phospholipids cardiolipin (CL) and phosphatidylglycerol (PG). phosphatidylethanolamine 136-138 twin-arginine translocation (TAT) pathway signal sequence domain protein Escherichia coli 40-43 28606933-1 2017 Phosphatidylserine decarboxylase 1 (Psd1p), an ancient enzyme that converts phosphatidylserine to phosphatidylethanolamine in the inner mitochondrial membrane, must undergo an autocatalytic self-processing event to gain activity. phosphatidylethanolamine 98-122 pleckstrin and Sec7 domain containing Homo sapiens 36-41 28606933-8 2017 We conclude that Psd1p, the key enzyme required for the mitochondrial pathway of phosphatidylethanolamine production, is closely monitored at several levels and by multiple mitochondrial quality control mechanisms present in the intermembrane space. phosphatidylethanolamine 81-105 pleckstrin and Sec7 domain containing Homo sapiens 17-22 28470758-2 2017 Their C-termini are physically attached to membranes through covalent linkage to primary amines on lipids such as phosphatidylethanolamine, while their ubiquitin-like fold domains bind "LIR" (LC3-Interacting Region) sequences found within an extraordinarily diverse array of proteins including regulators of autophagy, adaptors that recruit ubiquitinated cargoes to be degraded, and even proteins controlling processes at membranes that are not associated with autophagy. phosphatidylethanolamine 114-138 CD300c molecule Homo sapiens 186-189 28470758-2 2017 Their C-termini are physically attached to membranes through covalent linkage to primary amines on lipids such as phosphatidylethanolamine, while their ubiquitin-like fold domains bind "LIR" (LC3-Interacting Region) sequences found within an extraordinarily diverse array of proteins including regulators of autophagy, adaptors that recruit ubiquitinated cargoes to be degraded, and even proteins controlling processes at membranes that are not associated with autophagy. phosphatidylethanolamine 114-138 microtubule associated protein 1 light chain 3 alpha Homo sapiens 192-195 28784961-5 2017 In these studies, pH sensitive ortho-Sulforhodamine B conjugated phosphatidylethanolamine is used to detect protein-PIP interactions. phosphatidylethanolamine 65-89 prolactin induced protein Homo sapiens 116-119 28704563-6 2017 Consistent with the notion that cofactors influence rPrP-res conformation, the propagation of all rPrP-res formed with phosphatidylglycerol/RNA was cofactor-dependent, which is different from rPrP-res generated with a single cofactor, phosphatidylethanolamine. phosphatidylethanolamine 235-259 prion protein Rattus norvegicus 98-102 28704563-6 2017 Consistent with the notion that cofactors influence rPrP-res conformation, the propagation of all rPrP-res formed with phosphatidylglycerol/RNA was cofactor-dependent, which is different from rPrP-res generated with a single cofactor, phosphatidylethanolamine. phosphatidylethanolamine 235-259 prion protein Rattus norvegicus 98-102 28473294-1 2017 In the yeast Saccharomyces cerevisiae, the mitochondrial phosphatidylserine decarboxylase 1 (Psd1p) produces the largest amount of cellular phosphatidylethanolamine (PE). phosphatidylethanolamine 166-168 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 93-98 28259912-8 2017 Enhanced autophagy reduced cell death during the initial stages by restraining the functions of autophagy-associated genes (microtubule-associated protein 1A/1B-light chain 3 phosphatidylethanolamine conjugate and Beclin-1) and modulating the expression of inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1beta). phosphatidylethanolamine 175-199 microtubule associated protein 1A Homo sapiens 124-160 28408542-7 2017 It is shown that LPEAT activity (especially LPEAT2) is essential for maintaining adequate levels of phosphatidylethanolamine, LPE, and LPC in the cells. phosphatidylethanolamine 100-124 lysophosphatidylcholine acyltransferase 4 Homo sapiens 44-50 28521611-4 2017 SGPL1 cleaves S1P into ethanolamine phosphate, which is directed toward the synthesis of phosphatidylethanolamine (PE) that anchors LC3-I to phagophore membranes in the form of LC3-II. phosphatidylethanolamine 89-113 sphingosine phosphate lyase 1 Mus musculus 0-5 28521611-4 2017 SGPL1 cleaves S1P into ethanolamine phosphate, which is directed toward the synthesis of phosphatidylethanolamine (PE) that anchors LC3-I to phagophore membranes in the form of LC3-II. phosphatidylethanolamine 89-113 microtubule-associated protein 1 light chain 3 alpha Mus musculus 132-135 28521611-4 2017 SGPL1 cleaves S1P into ethanolamine phosphate, which is directed toward the synthesis of phosphatidylethanolamine (PE) that anchors LC3-I to phagophore membranes in the form of LC3-II. phosphatidylethanolamine 89-113 microtubule-associated protein 1 light chain 3 alpha Mus musculus 177-180 28521611-4 2017 SGPL1 cleaves S1P into ethanolamine phosphate, which is directed toward the synthesis of phosphatidylethanolamine (PE) that anchors LC3-I to phagophore membranes in the form of LC3-II. phosphatidylethanolamine 115-117 sphingosine phosphate lyase 1 Mus musculus 0-5 28521611-4 2017 SGPL1 cleaves S1P into ethanolamine phosphate, which is directed toward the synthesis of phosphatidylethanolamine (PE) that anchors LC3-I to phagophore membranes in the form of LC3-II. phosphatidylethanolamine 115-117 microtubule-associated protein 1 light chain 3 alpha Mus musculus 132-135 28521611-4 2017 SGPL1 cleaves S1P into ethanolamine phosphate, which is directed toward the synthesis of phosphatidylethanolamine (PE) that anchors LC3-I to phagophore membranes in the form of LC3-II. phosphatidylethanolamine 115-117 microtubule-associated protein 1 light chain 3 alpha Mus musculus 177-180 28521611-5 2017 In the brains of SGPL1fl/fl/Nes mice with developmental neural specific SGPL1 ablation, we observed significantly reduced PE levels. phosphatidylethanolamine 122-124 sphingosine phosphate lyase 1 Mus musculus 17-22 28521611-5 2017 In the brains of SGPL1fl/fl/Nes mice with developmental neural specific SGPL1 ablation, we observed significantly reduced PE levels. phosphatidylethanolamine 122-124 sphingosine phosphate lyase 1 Mus musculus 72-77 28366644-5 2017 Strikingly, cells that lack PE methylation accumulate SAM, which leads to hypermethylation of histones and the major phosphatase PP2A, dependency on cysteine, and sensitivity to oxidative stress. phosphatidylethanolamine 28-30 protein phosphatase 2 phosphatase activator Homo sapiens 129-133 28287329-1 2017 The cysteine protease ATG4B cleaves off one or more C-terminal residues of the inactive proform of proteins of the ortholog and paralog LC3 and GABARAP subfamilies of yeast Atg8 to expose a C-terminal glycine that is conjugated to phosphatidylethanolamine during autophagosome formation. phosphatidylethanolamine 231-255 autophagy related 4B, cysteine peptidase Mus musculus 22-27 28287329-1 2017 The cysteine protease ATG4B cleaves off one or more C-terminal residues of the inactive proform of proteins of the ortholog and paralog LC3 and GABARAP subfamilies of yeast Atg8 to expose a C-terminal glycine that is conjugated to phosphatidylethanolamine during autophagosome formation. phosphatidylethanolamine 231-255 gamma-aminobutyric acid receptor associated protein Mus musculus 144-151 28287329-1 2017 The cysteine protease ATG4B cleaves off one or more C-terminal residues of the inactive proform of proteins of the ortholog and paralog LC3 and GABARAP subfamilies of yeast Atg8 to expose a C-terminal glycine that is conjugated to phosphatidylethanolamine during autophagosome formation. phosphatidylethanolamine 231-255 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 173-177 28521611-0 2017 SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. phosphatidylethanolamine 71-95 sphingosine phosphate lyase 1 Mus musculus 0-5 28521611-0 2017 SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production. phosphatidylethanolamine 71-95 sphingosine phosphate lyase 1 Mus musculus 7-36 28420794-3 2017 Here the results of five independent techniques-surface plasmon resonance, electrochemical impedance spectroscopy, bilayer overtone analysis, neutron reflectometry, and molecular dynamics simulations-suggest that alpha-tubulin"s amphipathic helix H10 is responsible for peripheral binding of dimeric tubulin to biomimetic "mitochondrial" membranes in a manner that differentiates between the two primary lipid headgroups found in mitochondrial membranes, phosphatidylethanolamine and phosphatidylcholine. phosphatidylethanolamine 455-479 tubulin alpha 1b Homo sapiens 213-226 28254415-7 2017 Electrospray ionization mass spectrometry (ESI-MS) analysis showed that each hENT1 lipid disc contains 16 phosphatidylcholine (PC) and 2 phosphatidylethanolamine (PE) lipid molecules. phosphatidylethanolamine 137-161 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 77-82 28254415-7 2017 Electrospray ionization mass spectrometry (ESI-MS) analysis showed that each hENT1 lipid disc contains 16 phosphatidylcholine (PC) and 2 phosphatidylethanolamine (PE) lipid molecules. phosphatidylethanolamine 163-165 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 77-82 28330855-1 2017 Deconjugation of the Atg8/LC3 protein family members from phosphatidylethanolamine (PE) by Atg4 proteases is essential for autophagy progression, but how this event is regulated remains to be understood. phosphatidylethanolamine 58-82 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 21-25 28330855-1 2017 Deconjugation of the Atg8/LC3 protein family members from phosphatidylethanolamine (PE) by Atg4 proteases is essential for autophagy progression, but how this event is regulated remains to be understood. phosphatidylethanolamine 58-82 cysteine protease ATG4 Saccharomyces cerevisiae S288C 91-95 28330855-1 2017 Deconjugation of the Atg8/LC3 protein family members from phosphatidylethanolamine (PE) by Atg4 proteases is essential for autophagy progression, but how this event is regulated remains to be understood. phosphatidylethanolamine 84-86 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 21-25 28330855-1 2017 Deconjugation of the Atg8/LC3 protein family members from phosphatidylethanolamine (PE) by Atg4 proteases is essential for autophagy progression, but how this event is regulated remains to be understood. phosphatidylethanolamine 84-86 cysteine protease ATG4 Saccharomyces cerevisiae S288C 91-95 28330855-4 2017 We thus propose a model where Atg4 activity on autophagosomal membranes depends on the cooperative action of at least two sites within Atg4, in which one functions as a constitutive Atg8 binding module, while the other has a preference toward PE-bound Atg8. phosphatidylethanolamine 243-245 cysteine protease ATG4 Saccharomyces cerevisiae S288C 30-34 28330855-4 2017 We thus propose a model where Atg4 activity on autophagosomal membranes depends on the cooperative action of at least two sites within Atg4, in which one functions as a constitutive Atg8 binding module, while the other has a preference toward PE-bound Atg8. phosphatidylethanolamine 243-245 cysteine protease ATG4 Saccharomyces cerevisiae S288C 135-139 28322795-1 2017 We recently identified a peptide-peptoid hybrid, PPS1, which recognizes lipids that have an overall negative charge, such as phosphatidylserine (PS), phosphatidylglycerol (PG), phosphatidic acid (PA), and phosphatidylinositol (PI), but that does not bind to neutral lipids, such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM). phosphatidylethanolamine 308-332 interferon regulatory factor 6 Homo sapiens 49-53 28322795-1 2017 We recently identified a peptide-peptoid hybrid, PPS1, which recognizes lipids that have an overall negative charge, such as phosphatidylserine (PS), phosphatidylglycerol (PG), phosphatidic acid (PA), and phosphatidylinositol (PI), but that does not bind to neutral lipids, such as phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM). phosphatidylethanolamine 334-336 interferon regulatory factor 6 Homo sapiens 49-53 28264934-4 2017 The lipids cholesteryl hemisuccinate, linoleamide/oleamide, and phosphatidylethanolamine inhibit and phosphatidic acid and sphingomyelin enhance SPCA1a activity. phosphatidylethanolamine 64-88 ATPase secretory pathway Ca2+ transporting 1 Homo sapiens 145-150 28160743-5 2017 They are generated primarily via esterification of newly formed DXA3, but can also be formed in vitro via co-oxidation of PE during COX-1 co-oxidation of arachidonate. phosphatidylethanolamine 122-124 mitochondrially encoded cytochrome c oxidase I Homo sapiens 132-137 28069524-9 2017 We also identified a phosphatidylethanolamine (PE) binding region in ATG14, and the addition of Ulk1 to Hela-ATG14 cells decreased the ATG14-PE interaction. phosphatidylethanolamine 21-45 autophagy related 14 Homo sapiens 69-74 28436434-8 2017 Among them, a PE-biosynthetic enzyme, acyl-CoA:lysophosphatidylethanolamine acyltransferase 2 (LPEAT2), and two ATP-binding cassette (ABC) transporters, ABCB4 and ABCG1, were markedly increased during osteoclastogenesis, and their knockdown in pre-osteoclasts led to reduction in PE exposure on the cell surface and subsequent osteoclast fusion. phosphatidylethanolamine 14-16 lysophosphatidylcholine acyltransferase 4 Homo sapiens 38-93 28436434-8 2017 Among them, a PE-biosynthetic enzyme, acyl-CoA:lysophosphatidylethanolamine acyltransferase 2 (LPEAT2), and two ATP-binding cassette (ABC) transporters, ABCB4 and ABCG1, were markedly increased during osteoclastogenesis, and their knockdown in pre-osteoclasts led to reduction in PE exposure on the cell surface and subsequent osteoclast fusion. phosphatidylethanolamine 14-16 lysophosphatidylcholine acyltransferase 4 Homo sapiens 95-101 28436434-8 2017 Among them, a PE-biosynthetic enzyme, acyl-CoA:lysophosphatidylethanolamine acyltransferase 2 (LPEAT2), and two ATP-binding cassette (ABC) transporters, ABCB4 and ABCG1, were markedly increased during osteoclastogenesis, and their knockdown in pre-osteoclasts led to reduction in PE exposure on the cell surface and subsequent osteoclast fusion. phosphatidylethanolamine 14-16 ATP binding cassette subfamily B member 4 Homo sapiens 153-158 28436434-8 2017 Among them, a PE-biosynthetic enzyme, acyl-CoA:lysophosphatidylethanolamine acyltransferase 2 (LPEAT2), and two ATP-binding cassette (ABC) transporters, ABCB4 and ABCG1, were markedly increased during osteoclastogenesis, and their knockdown in pre-osteoclasts led to reduction in PE exposure on the cell surface and subsequent osteoclast fusion. phosphatidylethanolamine 14-16 ATP binding cassette subfamily G member 1 Homo sapiens 163-168 28436434-8 2017 Among them, a PE-biosynthetic enzyme, acyl-CoA:lysophosphatidylethanolamine acyltransferase 2 (LPEAT2), and two ATP-binding cassette (ABC) transporters, ABCB4 and ABCG1, were markedly increased during osteoclastogenesis, and their knockdown in pre-osteoclasts led to reduction in PE exposure on the cell surface and subsequent osteoclast fusion. phosphatidylethanolamine 96-98 lysophosphatidylcholine acyltransferase 4 Homo sapiens 38-93 28436434-9 2017 These findings demonstrate that the PE dynamics play an essential role in osteoclast fusion, in which LPEAT2, ABCB4 and ABCG1 are key players for PE biosynthesis and redistribution. phosphatidylethanolamine 36-38 lysophosphatidylcholine acyltransferase 4 Homo sapiens 102-108 28436434-9 2017 These findings demonstrate that the PE dynamics play an essential role in osteoclast fusion, in which LPEAT2, ABCB4 and ABCG1 are key players for PE biosynthesis and redistribution. phosphatidylethanolamine 36-38 ATP binding cassette subfamily B member 4 Homo sapiens 110-115 28436434-9 2017 These findings demonstrate that the PE dynamics play an essential role in osteoclast fusion, in which LPEAT2, ABCB4 and ABCG1 are key players for PE biosynthesis and redistribution. phosphatidylethanolamine 36-38 ATP binding cassette subfamily G member 1 Homo sapiens 120-125 28052917-2 2017 Here, we report an unusual autosomal recessive neurodegenerative condition, best classified as a complicated form of hereditary spastic paraplegia, associated with mutation in the ethanolaminephosphotransferase 1 (EPT1) gene (now known as SELENOI), responsible for the final step in Kennedy pathway forming phosphatidylethanolamine from CDP-ethanolamine. phosphatidylethanolamine 307-331 selenoprotein I Homo sapiens 180-212 28052917-2 2017 Here, we report an unusual autosomal recessive neurodegenerative condition, best classified as a complicated form of hereditary spastic paraplegia, associated with mutation in the ethanolaminephosphotransferase 1 (EPT1) gene (now known as SELENOI), responsible for the final step in Kennedy pathway forming phosphatidylethanolamine from CDP-ethanolamine. phosphatidylethanolamine 307-331 selenoprotein I Homo sapiens 214-218 28052917-2 2017 Here, we report an unusual autosomal recessive neurodegenerative condition, best classified as a complicated form of hereditary spastic paraplegia, associated with mutation in the ethanolaminephosphotransferase 1 (EPT1) gene (now known as SELENOI), responsible for the final step in Kennedy pathway forming phosphatidylethanolamine from CDP-ethanolamine. phosphatidylethanolamine 307-331 selenoprotein I Homo sapiens 239-246 28052917-4 2017 We determined that the mutation defined dramatically reduces the enzymatic activity of EPT1, thereby hindering the final step in phosphatidylethanolamine synthesis. phosphatidylethanolamine 129-153 selenoprotein I Homo sapiens 87-91 28327644-5 2017 We find that acetylation of Atg3 enhances its binding to phosphatidylethanolamine-containing liposomes and to endoplasmic reticulum, through which it promotes the lipidation process. phosphatidylethanolamine 57-81 autophagy related 3 Homo sapiens 28-32 28069524-9 2017 We also identified a phosphatidylethanolamine (PE) binding region in ATG14, and the addition of Ulk1 to Hela-ATG14 cells decreased the ATG14-PE interaction. phosphatidylethanolamine 21-45 unc-51 like autophagy activating kinase 1 Homo sapiens 96-100 28069524-9 2017 We also identified a phosphatidylethanolamine (PE) binding region in ATG14, and the addition of Ulk1 to Hela-ATG14 cells decreased the ATG14-PE interaction. phosphatidylethanolamine 21-45 autophagy related 14 Homo sapiens 109-114 28069524-9 2017 We also identified a phosphatidylethanolamine (PE) binding region in ATG14, and the addition of Ulk1 to Hela-ATG14 cells decreased the ATG14-PE interaction. phosphatidylethanolamine 21-45 autophagy related 14 Homo sapiens 109-114 28069524-9 2017 We also identified a phosphatidylethanolamine (PE) binding region in ATG14, and the addition of Ulk1 to Hela-ATG14 cells decreased the ATG14-PE interaction. phosphatidylethanolamine 47-49 autophagy related 14 Homo sapiens 69-74 28069524-9 2017 We also identified a phosphatidylethanolamine (PE) binding region in ATG14, and the addition of Ulk1 to Hela-ATG14 cells decreased the ATG14-PE interaction. phosphatidylethanolamine 47-49 unc-51 like autophagy activating kinase 1 Homo sapiens 96-100 28069524-9 2017 We also identified a phosphatidylethanolamine (PE) binding region in ATG14, and the addition of Ulk1 to Hela-ATG14 cells decreased the ATG14-PE interaction. phosphatidylethanolamine 141-143 autophagy related 14 Homo sapiens 69-74 28069524-9 2017 We also identified a phosphatidylethanolamine (PE) binding region in ATG14, and the addition of Ulk1 to Hela-ATG14 cells decreased the ATG14-PE interaction. phosphatidylethanolamine 141-143 unc-51 like autophagy activating kinase 1 Homo sapiens 96-100 28069524-9 2017 We also identified a phosphatidylethanolamine (PE) binding region in ATG14, and the addition of Ulk1 to Hela-ATG14 cells decreased the ATG14-PE interaction. phosphatidylethanolamine 141-143 autophagy related 14 Homo sapiens 109-114 28069524-9 2017 We also identified a phosphatidylethanolamine (PE) binding region in ATG14, and the addition of Ulk1 to Hela-ATG14 cells decreased the ATG14-PE interaction. phosphatidylethanolamine 141-143 autophagy related 14 Homo sapiens 109-114 28238968-5 2017 In skeletal muscle from aged mice, there also was a decline in LC3B-I conjugation to phosphatidylethanolamine (PE) possibly due to decreased protein levels of ATG3 and ATG12-ATG5. phosphatidylethanolamine 111-113 autophagy related 5 Mus musculus 174-178 28253958-1 2017 Autophagosome formation and specific substrate recruitment during autophagy require ligation of the ubiquitin-like protein (UBL) Atg8 to the head group of the lipid phosphatidylethanolamine. phosphatidylethanolamine 165-189 GABA type A receptor associated protein like 1 Homo sapiens 129-133 28127382-4 2017 RESULTS: Supplementation with MFGM mixtures enriched in polar lipids (BSC and CMLc, but not CML) increased the plasma phosphatidylcholine (PC) concentration, with no effect on plasma phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatidylserine (PS) or sphingomyelin (SM). phosphatidylethanolamine 210-234 milk fat globule EGF and factor V/VIII domain containing Rattus norvegicus 30-34 28127382-4 2017 RESULTS: Supplementation with MFGM mixtures enriched in polar lipids (BSC and CMLc, but not CML) increased the plasma phosphatidylcholine (PC) concentration, with no effect on plasma phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatidylserine (PS) or sphingomyelin (SM). phosphatidylethanolamine 236-238 milk fat globule EGF and factor V/VIII domain containing Rattus norvegicus 30-34 27913621-8 2017 Finally, we have provided in vivo evidence showing that activation of PPARdelta by agonist L165041 in mice increased hepatic LPCAT3 mRNA abundance and LPCAT enzymatic activity, which is associated with increased incorporations of arachidonate into liver phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 278-302 peroxisome proliferator activator receptor delta Mus musculus 70-79 27502688-6 2017 Phosphatidylethanolamine plays a pivotal role in supporting the autophagic process, including autophagosome elongation as part of lipidated Atg8/LC3. phosphatidylethanolamine 0-24 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 140-144 28158422-1 2017 Phosphatidylserine (PS) synthase (Cho1p) and the PS decarboxylase enzymes (Psd1p and Psd2p), which synthesize PS and phosphatidylethanolamine (PE), respectively, are crucial for Candida albicans virulence. phosphatidylethanolamine 117-141 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 34-39 28158422-1 2017 Phosphatidylserine (PS) synthase (Cho1p) and the PS decarboxylase enzymes (Psd1p and Psd2p), which synthesize PS and phosphatidylethanolamine (PE), respectively, are crucial for Candida albicans virulence. phosphatidylethanolamine 143-145 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 34-39 28854438-6 2017 RESULTS: We found that MALAT1, along with the levels of conversion from autophagy-related protein microtubule-associated protein light chain 3-I (LC3-I) to LC3-phosphatidylethanolamine conjugate (LC3-II), as well as Beclin1 were up-regulated and miR-30a was down-regulated in cerebral cortex neurons after oxygen-glucose deprivation (OGD) and mouse brain cortex after middle cerebral artery occlusion-reperfusion (MCAO). phosphatidylethanolamine 160-184 metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) Mus musculus 23-29 28854438-6 2017 RESULTS: We found that MALAT1, along with the levels of conversion from autophagy-related protein microtubule-associated protein light chain 3-I (LC3-I) to LC3-phosphatidylethanolamine conjugate (LC3-II), as well as Beclin1 were up-regulated and miR-30a was down-regulated in cerebral cortex neurons after oxygen-glucose deprivation (OGD) and mouse brain cortex after middle cerebral artery occlusion-reperfusion (MCAO). phosphatidylethanolamine 160-184 microtubule-associated protein 1 light chain 3 alpha Mus musculus 146-149 28854438-6 2017 RESULTS: We found that MALAT1, along with the levels of conversion from autophagy-related protein microtubule-associated protein light chain 3-I (LC3-I) to LC3-phosphatidylethanolamine conjugate (LC3-II), as well as Beclin1 were up-regulated and miR-30a was down-regulated in cerebral cortex neurons after oxygen-glucose deprivation (OGD) and mouse brain cortex after middle cerebral artery occlusion-reperfusion (MCAO). phosphatidylethanolamine 160-184 microtubule-associated protein 1 light chain 3 alpha Mus musculus 156-159 28854438-6 2017 RESULTS: We found that MALAT1, along with the levels of conversion from autophagy-related protein microtubule-associated protein light chain 3-I (LC3-I) to LC3-phosphatidylethanolamine conjugate (LC3-II), as well as Beclin1 were up-regulated and miR-30a was down-regulated in cerebral cortex neurons after oxygen-glucose deprivation (OGD) and mouse brain cortex after middle cerebral artery occlusion-reperfusion (MCAO). phosphatidylethanolamine 160-184 microtubule-associated protein 1 light chain 3 alpha Mus musculus 156-159 29430084-6 2017 Autoantibodies related to IL-23 were anti-phosphatidylethanolamine antibodies (OR = 11.06; 95% CI: 1.24-98.65) and anti-SS-B/La antibodies (OR = 15.43; 95% CI: 1.73-137.25). phosphatidylethanolamine 42-66 interleukin 23 subunit alpha Homo sapiens 26-31 27560294-1 2016 In Saccharomyces cerevisiae Atg8 coupled to phosphatidylethanolamine is a key component of autophagosome biogenesis. phosphatidylethanolamine 44-68 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 28-32 28253967-5 2017 In this system, the ubiquitin-like Atg8 protein is conjugated to the membrane lipid phosphatidylethanolamine present in autophagosomal membranes. phosphatidylethanolamine 84-108 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 35-39 28253979-1 2017 Humans express several orthologs of yeast Atg8, in the LC3 and GABARAP families, which play crucial roles in autophagy through their covalent ligation to lipids, typically phosphatidylethanolamine (PE), in a process known as lipidation. phosphatidylethanolamine 172-196 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 42-46 28253979-1 2017 Humans express several orthologs of yeast Atg8, in the LC3 and GABARAP families, which play crucial roles in autophagy through their covalent ligation to lipids, typically phosphatidylethanolamine (PE), in a process known as lipidation. phosphatidylethanolamine 172-196 microtubule associated protein 1 light chain 3 alpha Homo sapiens 55-58 28253979-1 2017 Humans express several orthologs of yeast Atg8, in the LC3 and GABARAP families, which play crucial roles in autophagy through their covalent ligation to lipids, typically phosphatidylethanolamine (PE), in a process known as lipidation. phosphatidylethanolamine 172-196 GABA type A receptor-associated protein Homo sapiens 63-70 28253979-1 2017 Humans express several orthologs of yeast Atg8, in the LC3 and GABARAP families, which play crucial roles in autophagy through their covalent ligation to lipids, typically phosphatidylethanolamine (PE), in a process known as lipidation. phosphatidylethanolamine 198-200 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 42-46 28253979-1 2017 Humans express several orthologs of yeast Atg8, in the LC3 and GABARAP families, which play crucial roles in autophagy through their covalent ligation to lipids, typically phosphatidylethanolamine (PE), in a process known as lipidation. phosphatidylethanolamine 198-200 microtubule associated protein 1 light chain 3 alpha Homo sapiens 55-58 28253979-1 2017 Humans express several orthologs of yeast Atg8, in the LC3 and GABARAP families, which play crucial roles in autophagy through their covalent ligation to lipids, typically phosphatidylethanolamine (PE), in a process known as lipidation. phosphatidylethanolamine 198-200 GABA type A receptor-associated protein Homo sapiens 63-70 28253979-5 2017 Ultimately, the ATG12~ATG5-ATG16L1 complex catalyzes LC3/GABARAP ligation to a primary amino group on PE or other acceptor lipids. phosphatidylethanolamine 102-104 autophagy related 5 Homo sapiens 22-26 28253979-5 2017 Ultimately, the ATG12~ATG5-ATG16L1 complex catalyzes LC3/GABARAP ligation to a primary amino group on PE or other acceptor lipids. phosphatidylethanolamine 102-104 autophagy related 16 like 1 Homo sapiens 27-34 28253979-5 2017 Ultimately, the ATG12~ATG5-ATG16L1 complex catalyzes LC3/GABARAP ligation to a primary amino group on PE or other acceptor lipids. phosphatidylethanolamine 102-104 microtubule associated protein 1 light chain 3 alpha Homo sapiens 53-56 28253979-5 2017 Ultimately, the ATG12~ATG5-ATG16L1 complex catalyzes LC3/GABARAP ligation to a primary amino group on PE or other acceptor lipids. phosphatidylethanolamine 102-104 GABA type A receptor-associated protein Homo sapiens 57-64 27746179-3 2016 By the mass spectrometry analysis, we demonstrate that Yor022c is actually a phospholipase displaying sn-1-specific activity toward phosphatidylcholine, phosphatidylethanolamine, and phosphatidic acid, generating 2-acyl lysophospholipids. phosphatidylethanolamine 153-177 putative carboxylic ester hydrolase Saccharomyces cerevisiae S288C 55-62 27540684-2 2016 MAP1LC3B/LC3B (microtubule- associated protein 1 light chain 3 beta) is conjugated with phosphatidylethanolamine (PE) in the membranes and regulates initiation of autophagy through interaction with many autophagy-related proteins possessing an LC3-interacting region (LIR) motif, which is composed of 2 hydrophobic amino acids (tryptophan and leucine) separated by 2 non-conserved amino acids (WXXL). phosphatidylethanolamine 88-112 microtubule associated protein 1 light chain 3 beta Homo sapiens 0-8 27540684-2 2016 MAP1LC3B/LC3B (microtubule- associated protein 1 light chain 3 beta) is conjugated with phosphatidylethanolamine (PE) in the membranes and regulates initiation of autophagy through interaction with many autophagy-related proteins possessing an LC3-interacting region (LIR) motif, which is composed of 2 hydrophobic amino acids (tryptophan and leucine) separated by 2 non-conserved amino acids (WXXL). phosphatidylethanolamine 88-112 microtubule associated protein 1 light chain 3 beta Homo sapiens 4-8 27436233-7 2016 Overexpression of SDC1 in planta increased levels of ethanolamine, phosphatidylethanolamine, and phosphatidylcholine both in leaves and siliques. phosphatidylethanolamine 67-91 Pyridoxal phosphate (PLP)-dependent transferases superfamily protein Arabidopsis thaliana 18-22 27891075-0 2016 BACE1 RNAi Restores the Composition of Phosphatidylethanolamine-Derivates Related to Memory Improvement in Aged 3xTg-AD Mice. phosphatidylethanolamine 39-63 beta-site APP cleaving enzyme 1 Mus musculus 0-5 27624766-8 2016 The lipids used for alpha-Syn capture consist of phosphatidyl inositol (PI), phosphatidyl serine (PS), and phosphatidyl ethanolamine (PE). phosphatidylethanolamine 134-136 synuclein alpha Homo sapiens 20-29 27540684-2 2016 MAP1LC3B/LC3B (microtubule- associated protein 1 light chain 3 beta) is conjugated with phosphatidylethanolamine (PE) in the membranes and regulates initiation of autophagy through interaction with many autophagy-related proteins possessing an LC3-interacting region (LIR) motif, which is composed of 2 hydrophobic amino acids (tryptophan and leucine) separated by 2 non-conserved amino acids (WXXL). phosphatidylethanolamine 88-112 microtubule associated protein 1 light chain 3 beta Homo sapiens 15-67 27540684-2 2016 MAP1LC3B/LC3B (microtubule- associated protein 1 light chain 3 beta) is conjugated with phosphatidylethanolamine (PE) in the membranes and regulates initiation of autophagy through interaction with many autophagy-related proteins possessing an LC3-interacting region (LIR) motif, which is composed of 2 hydrophobic amino acids (tryptophan and leucine) separated by 2 non-conserved amino acids (WXXL). phosphatidylethanolamine 88-112 microtubule associated protein 1 light chain 3 alpha Homo sapiens 4-7 27540684-2 2016 MAP1LC3B/LC3B (microtubule- associated protein 1 light chain 3 beta) is conjugated with phosphatidylethanolamine (PE) in the membranes and regulates initiation of autophagy through interaction with many autophagy-related proteins possessing an LC3-interacting region (LIR) motif, which is composed of 2 hydrophobic amino acids (tryptophan and leucine) separated by 2 non-conserved amino acids (WXXL). phosphatidylethanolamine 114-116 microtubule associated protein 1 light chain 3 beta Homo sapiens 0-8 27540684-2 2016 MAP1LC3B/LC3B (microtubule- associated protein 1 light chain 3 beta) is conjugated with phosphatidylethanolamine (PE) in the membranes and regulates initiation of autophagy through interaction with many autophagy-related proteins possessing an LC3-interacting region (LIR) motif, which is composed of 2 hydrophobic amino acids (tryptophan and leucine) separated by 2 non-conserved amino acids (WXXL). phosphatidylethanolamine 114-116 microtubule associated protein 1 light chain 3 beta Homo sapiens 4-8 27540684-2 2016 MAP1LC3B/LC3B (microtubule- associated protein 1 light chain 3 beta) is conjugated with phosphatidylethanolamine (PE) in the membranes and regulates initiation of autophagy through interaction with many autophagy-related proteins possessing an LC3-interacting region (LIR) motif, which is composed of 2 hydrophobic amino acids (tryptophan and leucine) separated by 2 non-conserved amino acids (WXXL). phosphatidylethanolamine 114-116 microtubule associated protein 1 light chain 3 beta Homo sapiens 15-67 27540684-2 2016 MAP1LC3B/LC3B (microtubule- associated protein 1 light chain 3 beta) is conjugated with phosphatidylethanolamine (PE) in the membranes and regulates initiation of autophagy through interaction with many autophagy-related proteins possessing an LC3-interacting region (LIR) motif, which is composed of 2 hydrophobic amino acids (tryptophan and leucine) separated by 2 non-conserved amino acids (WXXL). phosphatidylethanolamine 114-116 microtubule associated protein 1 light chain 3 alpha Homo sapiens 4-7 27540684-4 2016 PEBP1 was specifically bound to PE-unconjugated LC3 in cells, and mutation (WXXL mutated to AXXA) of this LIR motif disrupted its interaction with LC3 proteins. phosphatidylethanolamine 0-2 microtubule associated protein 1 light chain 3 alpha Homo sapiens 48-51 27540684-4 2016 PEBP1 was specifically bound to PE-unconjugated LC3 in cells, and mutation (WXXL mutated to AXXA) of this LIR motif disrupted its interaction with LC3 proteins. phosphatidylethanolamine 0-2 microtubule associated protein 1 light chain 3 alpha Homo sapiens 147-150 27760128-0 2016 Enrichment of Phosphatidylethanolamine in Viral Replication Compartments via Co-opting the Endosomal Rab5 Small GTPase by a Positive-Strand RNA Virus. phosphatidylethanolamine 14-38 RAB5A, member RAS oncogene family Homo sapiens 101-105 27738552-6 2016 Phosphatidylethanolamine (PE) has been implicated in Ypt7-dependent vacuolar membrane fusion in vitro and is a potential transport substrate of Neo1. phosphatidylethanolamine 0-24 Rab family GTPase YPT7 Saccharomyces cerevisiae S288C 53-57 27611931-1 2016 Monoacylglycerol acyltransferase 1 (Mogat1) catalyzes the conversion of monoacylglycerols (MAG) to diacylglycerols (DAG), the precursor of several physiologically important lipids such as phosphatidylcholine, phosphatidylethanolamine and triacylglycerol (TAG). phosphatidylethanolamine 209-233 monoacylglycerol O-acyltransferase 1 Homo sapiens 0-34 27611931-1 2016 Monoacylglycerol acyltransferase 1 (Mogat1) catalyzes the conversion of monoacylglycerols (MAG) to diacylglycerols (DAG), the precursor of several physiologically important lipids such as phosphatidylcholine, phosphatidylethanolamine and triacylglycerol (TAG). phosphatidylethanolamine 209-233 monoacylglycerol O-acyltransferase 1 Homo sapiens 36-42 27335143-7 2016 Sb06g012260 (SbFT12) contains a phosphatidylethanolamine-binding (PEBP) protein domain characteristic of members of the "FT" family of flowering genes acting as a floral suppressor. phosphatidylethanolamine 32-56 protein FLOWERING LOCUS T Sorghum bicolor 0-11 27584039-8 2016 Both PS and PE -containing membranes supported the formation of a fXa-PZ complex. phosphatidylethanolamine 12-14 coagulation factor X Homo sapiens 66-69 27235400-6 2016 However, the neo1-1(ts) and neo1-2(ts) mutants display a loss of PS and PE asymmetry at permissive growth temperatures as measured by hypersensitivity to pore-forming toxins that target PS (papuamide A) or PE (duramycin) exposed in the extracellular leaflet. phosphatidylethanolamine 72-74 putative aminophospholipid-translocating P4-type ATPase NEO1 Saccharomyces cerevisiae S288C 13-17 27235400-6 2016 However, the neo1-1(ts) and neo1-2(ts) mutants display a loss of PS and PE asymmetry at permissive growth temperatures as measured by hypersensitivity to pore-forming toxins that target PS (papuamide A) or PE (duramycin) exposed in the extracellular leaflet. phosphatidylethanolamine 72-74 putative aminophospholipid-translocating P4-type ATPase NEO1 Saccharomyces cerevisiae S288C 28-32 27235400-6 2016 However, the neo1-1(ts) and neo1-2(ts) mutants display a loss of PS and PE asymmetry at permissive growth temperatures as measured by hypersensitivity to pore-forming toxins that target PS (papuamide A) or PE (duramycin) exposed in the extracellular leaflet. phosphatidylethanolamine 206-208 putative aminophospholipid-translocating P4-type ATPase NEO1 Saccharomyces cerevisiae S288C 13-17 27235400-6 2016 However, the neo1-1(ts) and neo1-2(ts) mutants display a loss of PS and PE asymmetry at permissive growth temperatures as measured by hypersensitivity to pore-forming toxins that target PS (papuamide A) or PE (duramycin) exposed in the extracellular leaflet. phosphatidylethanolamine 206-208 putative aminophospholipid-translocating P4-type ATPase NEO1 Saccharomyces cerevisiae S288C 28-32 26721598-6 2016 We will show that oxidative modifications of PL by HOCl have a considerable impact on the PLA2 digestibility, i.e., oxidation of the unsaturated fatty acyl residues leads to a reduced digestibility of both PC and PE. phosphatidylethanolamine 213-215 phospholipase A2 group IB Homo sapiens 90-94 27738552-6 2016 Phosphatidylethanolamine (PE) has been implicated in Ypt7-dependent vacuolar membrane fusion in vitro and is a potential transport substrate of Neo1. phosphatidylethanolamine 0-24 putative aminophospholipid-translocating P4-type ATPase NEO1 Saccharomyces cerevisiae S288C 144-148 27738552-6 2016 Phosphatidylethanolamine (PE) has been implicated in Ypt7-dependent vacuolar membrane fusion in vitro and is a potential transport substrate of Neo1. phosphatidylethanolamine 26-28 Rab family GTPase YPT7 Saccharomyces cerevisiae S288C 53-57 27738552-6 2016 Phosphatidylethanolamine (PE) has been implicated in Ypt7-dependent vacuolar membrane fusion in vitro and is a potential transport substrate of Neo1. phosphatidylethanolamine 26-28 putative aminophospholipid-translocating P4-type ATPase NEO1 Saccharomyces cerevisiae S288C 144-148 27738552-7 2016 Strains deficient in PE synthesis (psd1Delta psd2Delta) displayed fragmented vacuoles and the neo1-2 fragmented vacuole phenotype was also suppressed by overexpression of PSD2, encoding a phosphatidylserine decarboxylase that produces PE at endosomes. phosphatidylethanolamine 21-23 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 35-39 27738552-7 2016 Strains deficient in PE synthesis (psd1Delta psd2Delta) displayed fragmented vacuoles and the neo1-2 fragmented vacuole phenotype was also suppressed by overexpression of PSD2, encoding a phosphatidylserine decarboxylase that produces PE at endosomes. phosphatidylethanolamine 21-23 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 171-175 27738552-9 2016 These results support the crucial role of PE in vacuole membrane fusion and implicate Neo1 in concentrating PE in the cytosolic leaflet of Golgi and endosomes, and ultimately the vacuole membrane. phosphatidylethanolamine 108-110 putative aminophospholipid-translocating P4-type ATPase NEO1 Saccharomyces cerevisiae S288C 86-90 27277390-1 2016 We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively. phosphatidylethanolamine 181-205 ATPase phospholipid transporting 11C Homo sapiens 64-70 27354379-3 2016 Here, we provide evidence that Ups2-Mdm35, a protein complex localized at the mitochondrial intermembrane space, mediates PS transport for PE synthesis in respiration-active mitochondria. phosphatidylethanolamine 139-141 Ups2p Saccharomyces cerevisiae S288C 31-35 27354379-3 2016 Here, we provide evidence that Ups2-Mdm35, a protein complex localized at the mitochondrial intermembrane space, mediates PS transport for PE synthesis in respiration-active mitochondria. phosphatidylethanolamine 139-141 Mdm35p Saccharomyces cerevisiae S288C 36-41 27354379-7 2016 These results demonstrate that Ups2-Mdm35 functions as a PS transfer protein and enhances mitochondrial PE synthesis in response to the cellular metabolic state. phosphatidylethanolamine 104-106 Ups2p Saccharomyces cerevisiae S288C 31-35 27354379-7 2016 These results demonstrate that Ups2-Mdm35 functions as a PS transfer protein and enhances mitochondrial PE synthesis in response to the cellular metabolic state. phosphatidylethanolamine 104-106 Mdm35p Saccharomyces cerevisiae S288C 36-41 27032901-0 2016 Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and respond to acute exercise in humans. phosphatidylethanolamine 40-64 insulin Homo sapiens 80-87 27241913-2 2016 Here, we demonstrate that the phosphatidylserine decarboxylase Psd1, located in the inner mitochondrial membrane, promotes mitochondrial PE synthesis via two pathways. phosphatidylethanolamine 137-139 pleckstrin and Sec7 domain containing Homo sapiens 63-67 27032901-10 2016 In summary, total muscle PC and PE are positively related to insulin sensitivity while PC:PE ratio is inversely related to insulin sensitivity in humans. phosphatidylethanolamine 32-34 insulin Homo sapiens 61-68 27216961-5 2016 TRIM31 directly interacts with phosphatidylethanolamine in a palmitoylation-dependent manner, leading to induction of autolysosome formation. phosphatidylethanolamine 31-55 tripartite motif containing 31 Homo sapiens 0-6 27277390-1 2016 We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively. phosphatidylethanolamine 181-205 ATPase phospholipid transporting 10A (putative) Homo sapiens 38-44 27277390-1 2016 We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively. phosphatidylethanolamine 181-205 ATPase phospholipid transporting 8B1 Homo sapiens 45-51 27277390-1 2016 We previously showed that P4-ATPases, ATP10A/ATP8B1, and ATP11A/ATP11C have flippase activities toward phosphatidylcholine (PC), and aminophospholipids [phosphatidylserine (PS) and phosphatidylethanolamine], respectively. phosphatidylethanolamine 181-205 ATPase phospholipid transporting 11A Homo sapiens 57-63 27015965-0 2016 Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE-/- mice and activate platelets via TLR2. phosphatidylethanolamine 6-30 apolipoprotein E Mus musculus 87-91 27015965-0 2016 Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE-/- mice and activate platelets via TLR2. phosphatidylethanolamine 6-30 toll-like receptor 2 Mus musculus 127-131 27184816-4 2016 The expression of phosphatidylethanolamine-modified microtubule-associated protein light-chain 3 (LC3-II) and formation of GFP-LC3 punta, two autophagic markers, were increased after treatment with LCA. phosphatidylethanolamine 18-42 clathrin light chain A Homo sapiens 198-201 26363509-11 2016 TNF-alpha and IFN-gamma also enhanced the levels of PE(40:6) and decreased the levels of PE(O-38:6). phosphatidylethanolamine 52-54 tumor necrosis factor Homo sapiens 0-9 26363509-11 2016 TNF-alpha and IFN-gamma also enhanced the levels of PE(40:6) and decreased the levels of PE(O-38:6). phosphatidylethanolamine 52-54 interferon gamma Homo sapiens 14-23 26363509-11 2016 TNF-alpha and IFN-gamma also enhanced the levels of PE(40:6) and decreased the levels of PE(O-38:6). phosphatidylethanolamine 89-91 tumor necrosis factor Homo sapiens 0-9 26363509-11 2016 TNF-alpha and IFN-gamma also enhanced the levels of PE(40:6) and decreased the levels of PE(O-38:6). phosphatidylethanolamine 89-91 interferon gamma Homo sapiens 14-23 26662804-3 2016 ATG4B, a cysteine protease required for autophagy, cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine which is necessary for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to autophagosome precursor membranes. phosphatidylethanolamine 192-216 autophagy related 4B cysteine peptidase Homo sapiens 0-5 26662804-3 2016 ATG4B, a cysteine protease required for autophagy, cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine which is necessary for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to autophagosome precursor membranes. phosphatidylethanolamine 192-216 GABA type A receptor associated protein like 1 Homo sapiens 88-92 26662804-3 2016 ATG4B, a cysteine protease required for autophagy, cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine which is necessary for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to autophagosome precursor membranes. phosphatidylethanolamine 192-216 GABA type A receptor associated protein like 1 Homo sapiens 163-167 26662804-3 2016 ATG4B, a cysteine protease required for autophagy, cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine which is necessary for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to autophagosome precursor membranes. phosphatidylethanolamine 218-220 autophagy related 4B cysteine peptidase Homo sapiens 0-5 26662804-3 2016 ATG4B, a cysteine protease required for autophagy, cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine which is necessary for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to autophagosome precursor membranes. phosphatidylethanolamine 218-220 GABA type A receptor associated protein like 1 Homo sapiens 88-92 26662804-3 2016 ATG4B, a cysteine protease required for autophagy, cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine which is necessary for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to autophagosome precursor membranes. phosphatidylethanolamine 218-220 GABA type A receptor associated protein like 1 Homo sapiens 163-167 26807725-1 2016 BACKGROUND: Ethanolamine kinase (EK) catalyzes the phosphorylation of ethanolamine, the first step in the CDP-ethanolamine pathway for the biosynthesis of phosphatidylethanolamine (PE). phosphatidylethanolamine 155-179 choline kinase alpha Homo sapiens 12-31 27040328-9 2016 We also show the differential binding of CD300a and CD300c to their ligands phosphatidylethanolamine (PE) and phosphatidylserine (PS) and their differential ability to affect CD56(bright) NK cell functions. phosphatidylethanolamine 76-100 CD300a molecule Homo sapiens 41-47 27040328-9 2016 We also show the differential binding of CD300a and CD300c to their ligands phosphatidylethanolamine (PE) and phosphatidylserine (PS) and their differential ability to affect CD56(bright) NK cell functions. phosphatidylethanolamine 76-100 CD300c molecule Homo sapiens 52-58 27040328-9 2016 We also show the differential binding of CD300a and CD300c to their ligands phosphatidylethanolamine (PE) and phosphatidylserine (PS) and their differential ability to affect CD56(bright) NK cell functions. phosphatidylethanolamine 102-104 CD300a molecule Homo sapiens 41-47 27040328-9 2016 We also show the differential binding of CD300a and CD300c to their ligands phosphatidylethanolamine (PE) and phosphatidylserine (PS) and their differential ability to affect CD56(bright) NK cell functions. phosphatidylethanolamine 102-104 CD300c molecule Homo sapiens 52-58 26499445-0 2016 GM3 ganglioside and phosphatidylethanolamine-containing lipids are adipose tissue markers of insulin resistance in obese women. phosphatidylethanolamine 20-44 insulin Homo sapiens 93-100 26813886-4 2016 Pin-b wild type was able to penetrate mixed layers of phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) head groups more deeply compared to the mutant Pin-bs. phosphatidylethanolamine 54-78 dynein light chain LC8-type 1 Homo sapiens 0-3 26813886-4 2016 Pin-b wild type was able to penetrate mixed layers of phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) head groups more deeply compared to the mutant Pin-bs. phosphatidylethanolamine 80-82 dynein light chain LC8-type 1 Homo sapiens 0-3 26838333-5 2016 Nevertheless, Sey1p-dependent lipid mixing was strongly reduced by omitting three major acidic lipids from the ER-mimicking set and, moreover, was entirely abolished by omitting either phosphatidylethanolamine or ergosterol. phosphatidylethanolamine 185-209 dynamin-like GTPase SEY1 Saccharomyces cerevisiae S288C 14-19 26603903-1 2016 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. phosphatidylethanolamine 61-85 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 26603903-1 2016 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. phosphatidylethanolamine 61-85 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 26603903-1 2016 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine (PE) to phosphatidylcholine (PC) in the liver. phosphatidylethanolamine 46-48 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 26832685-3 2016 Atg8/LC3 is initially synthesized as an unprocessed form, which is proteolytically processed to form Atg8/LC3-I, and then this is modified into the phosphatidylethanolamine (PE)-conjugated Atg8-PE/LC3-II form. phosphatidylethanolamine 148-172 GABA type A receptor associated protein like 1 Homo sapiens 0-4 26832685-3 2016 Atg8/LC3 is initially synthesized as an unprocessed form, which is proteolytically processed to form Atg8/LC3-I, and then this is modified into the phosphatidylethanolamine (PE)-conjugated Atg8-PE/LC3-II form. phosphatidylethanolamine 148-172 microtubule associated protein 1 light chain 3 alpha Homo sapiens 5-8 26832685-3 2016 Atg8/LC3 is initially synthesized as an unprocessed form, which is proteolytically processed to form Atg8/LC3-I, and then this is modified into the phosphatidylethanolamine (PE)-conjugated Atg8-PE/LC3-II form. phosphatidylethanolamine 174-176 GABA type A receptor associated protein like 1 Homo sapiens 0-4 26832685-3 2016 Atg8/LC3 is initially synthesized as an unprocessed form, which is proteolytically processed to form Atg8/LC3-I, and then this is modified into the phosphatidylethanolamine (PE)-conjugated Atg8-PE/LC3-II form. phosphatidylethanolamine 174-176 microtubule associated protein 1 light chain 3 alpha Homo sapiens 5-8 26832685-3 2016 Atg8/LC3 is initially synthesized as an unprocessed form, which is proteolytically processed to form Atg8/LC3-I, and then this is modified into the phosphatidylethanolamine (PE)-conjugated Atg8-PE/LC3-II form. phosphatidylethanolamine 194-196 GABA type A receptor associated protein like 1 Homo sapiens 0-4 26832685-3 2016 Atg8/LC3 is initially synthesized as an unprocessed form, which is proteolytically processed to form Atg8/LC3-I, and then this is modified into the phosphatidylethanolamine (PE)-conjugated Atg8-PE/LC3-II form. phosphatidylethanolamine 194-196 microtubule associated protein 1 light chain 3 alpha Homo sapiens 5-8 26499445-5 2016 RESULTS: In omental adipose tissue of obese, insulin-resistant women, adipocyte hypertrophy and macrophage infiltration were accompanied by an increase in GM3 ganglioside and its synthesis enzyme ST3GAL5; in addition, phosphatidylethanolamine (PE) lipids were increased and their degradation enzyme, phosphatidylethanolamine methyl transferase (PEMT), decreased. phosphatidylethanolamine 244-246 insulin Homo sapiens 45-52 26499445-5 2016 RESULTS: In omental adipose tissue of obese, insulin-resistant women, adipocyte hypertrophy and macrophage infiltration were accompanied by an increase in GM3 ganglioside and its synthesis enzyme ST3GAL5; in addition, phosphatidylethanolamine (PE) lipids were increased and their degradation enzyme, phosphatidylethanolamine methyl transferase (PEMT), decreased. phosphatidylethanolamine 244-246 granulocyte macrophage antigen 3 Mus musculus 155-158 26807725-1 2016 BACKGROUND: Ethanolamine kinase (EK) catalyzes the phosphorylation of ethanolamine, the first step in the CDP-ethanolamine pathway for the biosynthesis of phosphatidylethanolamine (PE). phosphatidylethanolamine 181-183 choline kinase alpha Homo sapiens 12-31 26438561-5 2015 We found that PGC-1alpha affected lipid profiles in skeletal muscle and increased several phospholipid species in glycolytic muscle, namely phosphatidylcholine (PC) (18:0/22:6) and phosphatidylethanolamine (PE) (18:0/22:6). phosphatidylethanolamine 181-205 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 14-24 26799398-5 2016 Loss of ATP11C resulted in a defective internalization of phosphatidylserine (PS) and phosphatidylethanolamine (PE) in comparison to control cells. phosphatidylethanolamine 86-110 ATPase, class VI, type 11C Mus musculus 8-14 26799398-5 2016 Loss of ATP11C resulted in a defective internalization of phosphatidylserine (PS) and phosphatidylethanolamine (PE) in comparison to control cells. phosphatidylethanolamine 112-114 ATPase, class VI, type 11C Mus musculus 8-14 26902585-2 2016 LC3 is conjugated to phosphatidylethanolamine on phagophores and ends up distributed both inside and outside the autophagosome membrane. phosphatidylethanolamine 21-45 microtubule associated protein 1 light chain 3 alpha Homo sapiens 0-3 27046250-6 2016 By monitoring the ATG14 phosphorylation, we determined that the ULK1 activity requires BECN1/Beclin 1 but not the phosphatidylethanolamine (PE)-conjugation machinery and the PIK3C3 kinase activity. phosphatidylethanolamine 114-138 unc-51 like autophagy activating kinase 1 Homo sapiens 64-68 27245897-1 2016 In animal tissues, N-acyltransferase (NAT) catalyzes the first reaction in the biosynthetic pathway of bioactive N-acylethanolamines, in which an acyl chain is transferred from the sn-1 position of the donor phospholipid, such as phosphatidylcholine, to the amino group of phosphatidylethanolamine, resulting in the formation of N-acylphosphatidylethanolamine. phosphatidylethanolamine 273-297 bromodomain containing 2 Homo sapiens 19-36 27245897-1 2016 In animal tissues, N-acyltransferase (NAT) catalyzes the first reaction in the biosynthetic pathway of bioactive N-acylethanolamines, in which an acyl chain is transferred from the sn-1 position of the donor phospholipid, such as phosphatidylcholine, to the amino group of phosphatidylethanolamine, resulting in the formation of N-acylphosphatidylethanolamine. phosphatidylethanolamine 273-297 bromodomain containing 2 Homo sapiens 38-41 26443863-1 2015 Phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae is synthesized through decarboxylation of phosphatidylserine (PS), catalysed by PS decarboxylase 1 (Psd1p) and 2 (Psd2p) and the cytidine 5"-diphosphate (CDP)-ethanolamine (CDP-Etn) pathway. phosphatidylethanolamine 0-24 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 168-173 26443863-1 2015 Phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae is synthesized through decarboxylation of phosphatidylserine (PS), catalysed by PS decarboxylase 1 (Psd1p) and 2 (Psd2p) and the cytidine 5"-diphosphate (CDP)-ethanolamine (CDP-Etn) pathway. phosphatidylethanolamine 0-24 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 182-187 26443863-1 2015 Phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae is synthesized through decarboxylation of phosphatidylserine (PS), catalysed by PS decarboxylase 1 (Psd1p) and 2 (Psd2p) and the cytidine 5"-diphosphate (CDP)-ethanolamine (CDP-Etn) pathway. phosphatidylethanolamine 26-28 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 168-173 26443863-1 2015 Phosphatidylethanolamine (PE) in the yeast Saccharomyces cerevisiae is synthesized through decarboxylation of phosphatidylserine (PS), catalysed by PS decarboxylase 1 (Psd1p) and 2 (Psd2p) and the cytidine 5"-diphosphate (CDP)-ethanolamine (CDP-Etn) pathway. phosphatidylethanolamine 26-28 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 182-187 26443863-8 2015 Deletion of VID22 in wild-type and PSD1-depressed cells caused partial defects in PE formation through decarboxylation of PS. phosphatidylethanolamine 82-84 Vid22p Saccharomyces cerevisiae S288C 12-17 26443863-8 2015 Deletion of VID22 in wild-type and PSD1-depressed cells caused partial defects in PE formation through decarboxylation of PS. phosphatidylethanolamine 82-84 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 35-39 26391255-2 2015 Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme located on the ER and mitochondria-associated membranes and catalyzes phosphatidylcholine (PC) synthesis via methylation of phosphatidylethanolamine (PE). phosphatidylethanolamine 196-220 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 26391255-2 2015 Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme located on the ER and mitochondria-associated membranes and catalyzes phosphatidylcholine (PC) synthesis via methylation of phosphatidylethanolamine (PE). phosphatidylethanolamine 196-220 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 26391255-2 2015 Phosphatidylethanolamine N-methyltransferase (PEMT) is a hepatic enzyme located on the ER and mitochondria-associated membranes and catalyzes phosphatidylcholine (PC) synthesis via methylation of phosphatidylethanolamine (PE). phosphatidylethanolamine 46-48 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 26697781-5 2016 Autophagy 8 (ATG8, in mammals LC3), a well-established marker of autophagy, is covalently linked to phosphatidylethanolamine on the autophagic membrane during autophagosome formation. phosphatidylethanolamine 100-124 GABA type A receptor associated protein like 1 Homo sapiens 0-11 26697781-5 2016 Autophagy 8 (ATG8, in mammals LC3), a well-established marker of autophagy, is covalently linked to phosphatidylethanolamine on the autophagic membrane during autophagosome formation. phosphatidylethanolamine 100-124 GABA type A receptor associated protein like 1 Homo sapiens 13-17 26697781-5 2016 Autophagy 8 (ATG8, in mammals LC3), a well-established marker of autophagy, is covalently linked to phosphatidylethanolamine on the autophagic membrane during autophagosome formation. phosphatidylethanolamine 100-124 microtubule associated protein 1 light chain 3 alpha Homo sapiens 30-33 26669658-5 2015 Lipid profiling by mass spectrometry of mitochondria isolated from Mdm33-overexpressing cells revealed that high levels of Mdm33 affect the levels of phosphatidylethanolamine and cardiolipin, the two key inner membrane phospholipids. phosphatidylethanolamine 150-174 She9p Saccharomyces cerevisiae S288C 67-72 26669658-5 2015 Lipid profiling by mass spectrometry of mitochondria isolated from Mdm33-overexpressing cells revealed that high levels of Mdm33 affect the levels of phosphatidylethanolamine and cardiolipin, the two key inner membrane phospholipids. phosphatidylethanolamine 150-174 She9p Saccharomyces cerevisiae S288C 123-128 26417903-0 2015 Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. phosphatidylethanolamine 147-171 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Mus musculus 0-38 26417903-0 2015 Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial lysophosphatidic acid acyltransferase that regulates brain phosphatidylcholine, phosphatidylethanolamine, and phosphatidylinositol levels. phosphatidylethanolamine 147-171 1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta) Mus musculus 40-46 26438561-5 2015 We found that PGC-1alpha affected lipid profiles in skeletal muscle and increased several phospholipid species in glycolytic muscle, namely phosphatidylcholine (PC) (18:0/22:6) and phosphatidylethanolamine (PE) (18:0/22:6). phosphatidylethanolamine 207-209 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha Mus musculus 14-24 26290611-7 2015 ACBD1 and ACBD6 negatively affected the formation of phosphatidylcholine (PC) and phosphatidylethanolamine in the red blood cell membrane. phosphatidylethanolamine 82-106 diazepam binding inhibitor, acyl-CoA binding protein Homo sapiens 0-5 26588566-3 2015 Here, we define the course of spontaneous membrane insertion of LC3 protein modified with phosphatidylethanolamine using multiple coarse-grain simulations. phosphatidylethanolamine 90-114 microtubule associated protein 1 light chain 3 alpha Homo sapiens 64-67 26588566-5 2015 Concurrently, a conformational rearrangement involving the alpha-helix III of LC3, especially in the three basic residues Lys65, Arg68, and Arg69, ensures stable insertion of the phosphatidylethanolamine anchor into membranes. phosphatidylethanolamine 179-203 microtubule associated protein 1 light chain 3 alpha Homo sapiens 78-81 26438722-3 2015 Here, we show that mitophagy in yeast is linked to the phospholipid biosynthesis pathway for conversion of phosphatidylethanolamine to phosphatidylcholine by the two methyltransferases Cho2 and Opi3. phosphatidylethanolamine 107-131 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 185-189 26438722-3 2015 Here, we show that mitophagy in yeast is linked to the phospholipid biosynthesis pathway for conversion of phosphatidylethanolamine to phosphatidylcholine by the two methyltransferases Cho2 and Opi3. phosphatidylethanolamine 107-131 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 194-198 26242921-3 2015 In Pcyt2(+/-) mice, the membrane phosphatidylethanolamine (PE) turnover is reduced and the formation of fatty acids (FA) and triglycerides (TAG) increased, resulting in hypertriglyceridemia, liver steatosis and obesity. phosphatidylethanolamine 33-57 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 3-8 26242921-3 2015 In Pcyt2(+/-) mice, the membrane phosphatidylethanolamine (PE) turnover is reduced and the formation of fatty acids (FA) and triglycerides (TAG) increased, resulting in hypertriglyceridemia, liver steatosis and obesity. phosphatidylethanolamine 59-61 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 3-8 26283787-7 2015 Our in vivo EM images of immunogold-labeled rat IAPP and human IAPP show both forms to localize to mitochondrial cristae, which contain not only locally curved membranes but also phosphatidylethanolamine and cardiolipin, lipids with high spontaneous negative curvature. phosphatidylethanolamine 179-203 islet amyloid polypeptide Rattus norvegicus 48-52 26283787-7 2015 Our in vivo EM images of immunogold-labeled rat IAPP and human IAPP show both forms to localize to mitochondrial cristae, which contain not only locally curved membranes but also phosphatidylethanolamine and cardiolipin, lipids with high spontaneous negative curvature. phosphatidylethanolamine 179-203 islet amyloid polypeptide Homo sapiens 63-67 26468529-6 2016 CD300a recognizes predominantly phosphatidylethanolamine (PtdEth) and to a lesser extent PtdSer associated with viral particles. phosphatidylethanolamine 32-56 CD300a molecule Homo sapiens 0-6 26468529-6 2016 CD300a recognizes predominantly phosphatidylethanolamine (PtdEth) and to a lesser extent PtdSer associated with viral particles. phosphatidylethanolamine 58-64 CD300a molecule Homo sapiens 0-6 26468529-14 2016 CD300a-dependent DENV infection relies on the direct recognition of phosphatidylethanolamine and to a lesser extent PtdSer associated with viral particles. phosphatidylethanolamine 68-92 CD300a molecule Homo sapiens 0-6 25790072-6 2015 The levels of plastid-synthesized lipids, mono- and di-galactosyldiacylglycerol and phosphatidylglycerol were reduced more in senescence-induced LEC2 than in endoplasmic reticulum-synthesized lipids, including phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol. phosphatidylethanolamine 231-255 AP2/B3-like transcriptional factor family protein Arabidopsis thaliana 145-149 26290611-7 2015 ACBD1 and ACBD6 negatively affected the formation of phosphatidylcholine (PC) and phosphatidylethanolamine in the red blood cell membrane. phosphatidylethanolamine 82-106 acyl-CoA binding domain containing 6 Homo sapiens 10-15 26402709-4 2015 Our results also suggest that Tat peptides may more frequently insert into the hydrophobic core of bilayers composed of PC:PE (1:1) lipids than into bilayers composed entirely of PC lipids. phosphatidylethanolamine 123-125 tyrosine aminotransferase Homo sapiens 30-33 26295742-7 2015 Phosphatidylcholine and phosphatidylethanolamine (PE) demonstrated the largest consumption of mass during thrombin stimulation. phosphatidylethanolamine 24-48 coagulation factor II, thrombin Homo sapiens 106-114 26295742-7 2015 Phosphatidylcholine and phosphatidylethanolamine (PE) demonstrated the largest consumption of mass during thrombin stimulation. phosphatidylethanolamine 50-52 coagulation factor II, thrombin Homo sapiens 106-114 26322888-12 2015 The phosphatidylcholine (PC)/ phosphatidylethanolamine (PE) ratio increased significantly (p< 0.01), indicative of increased phosphatidylethanolamine methyltransferase (PEMT) activity. phosphatidylethanolamine 56-58 phosphatidylethanolamine N-methyltransferase Mus musculus 128-170 26310456-1 2015 Pcyt2 (CTP:phosphoethanolamine cytidylyltransferase) is the rate-limiting enzyme in mammalian PE (phosphatidylethanolamine) biosynthesis. phosphatidylethanolamine 94-96 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 0-5 26310456-1 2015 Pcyt2 (CTP:phosphoethanolamine cytidylyltransferase) is the rate-limiting enzyme in mammalian PE (phosphatidylethanolamine) biosynthesis. phosphatidylethanolamine 94-96 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 7-51 26310456-1 2015 Pcyt2 (CTP:phosphoethanolamine cytidylyltransferase) is the rate-limiting enzyme in mammalian PE (phosphatidylethanolamine) biosynthesis. phosphatidylethanolamine 98-122 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 0-5 26310456-1 2015 Pcyt2 (CTP:phosphoethanolamine cytidylyltransferase) is the rate-limiting enzyme in mammalian PE (phosphatidylethanolamine) biosynthesis. phosphatidylethanolamine 98-122 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 7-51 26327557-1 2015 In a previous study we demonstrated up-regulation of the yeast GPH1 gene under conditions of phosphatidylethanolamine (PE) depletion caused by deletion of the mitochondrial (M) phosphatidylserine decarboxylase 1 (PSD1) (Gsell et al., 2013, PLoS One. phosphatidylethanolamine 93-117 glycogen phosphorylase Saccharomyces cerevisiae S288C 63-67 26327557-1 2015 In a previous study we demonstrated up-regulation of the yeast GPH1 gene under conditions of phosphatidylethanolamine (PE) depletion caused by deletion of the mitochondrial (M) phosphatidylserine decarboxylase 1 (PSD1) (Gsell et al., 2013, PLoS One. phosphatidylethanolamine 93-117 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 213-217 26331251-8 2015 Therefore, PS and PE lipids synergistically combine to enhance membrane poration by MP1, implying that the combined enrichment of both these lipids in the outer leaflet of cancer cells is highly significant for MP1"s anticancer action. phosphatidylethanolamine 18-20 pitrilysin metallopeptidase 1 Homo sapiens 211-214 26327557-1 2015 In a previous study we demonstrated up-regulation of the yeast GPH1 gene under conditions of phosphatidylethanolamine (PE) depletion caused by deletion of the mitochondrial (M) phosphatidylserine decarboxylase 1 (PSD1) (Gsell et al., 2013, PLoS One. phosphatidylethanolamine 119-121 glycogen phosphorylase Saccharomyces cerevisiae S288C 63-67 26327557-1 2015 In a previous study we demonstrated up-regulation of the yeast GPH1 gene under conditions of phosphatidylethanolamine (PE) depletion caused by deletion of the mitochondrial (M) phosphatidylserine decarboxylase 1 (PSD1) (Gsell et al., 2013, PLoS One. phosphatidylethanolamine 119-121 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 213-217 26241051-2 2015 Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation. phosphatidylethanolamine 15-39 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 82-87 26241051-2 2015 Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation. phosphatidylethanolamine 15-39 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 88-93 26241051-2 2015 Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation. phosphatidylethanolamine 15-39 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 98-103 26241051-2 2015 Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation. phosphatidylethanolamine 15-39 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 104-109 26241051-2 2015 Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation. phosphatidylethanolamine 41-43 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 82-87 26241051-2 2015 Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation. phosphatidylethanolamine 41-43 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 88-93 26241051-2 2015 Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation. phosphatidylethanolamine 41-43 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 98-103 26241051-2 2015 Methylation of phosphatidylethanolamine (PE) catalyzed by the methyl transferases Cho2p/Pem1p and Opi3p/Pem2p as well as incorporation of choline through the CDP (cytidine diphosphate)-choline branch of the Kennedy pathway lead to PC formation. phosphatidylethanolamine 41-43 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 104-109 26109138-6 2015 NPe6 (25 mug/ml)-PDT treatment also induced conversion of microtubule-associated protein 1 light-chain 3 (LC3)-I into phosphatidylethanolamine-conjugated LC3-II accompanying autophagosome formation, indicators of autophagy; however, of note, NPe6 (50 mug/ml)-PDT did not induce such autophagic changes. phosphatidylethanolamine 118-142 microtubule associated protein 1 light chain 3 alpha Homo sapiens 154-157 26265748-6 2015 Moreover, PLIN4 mRNA expression levels in muscle correlated with the expression of genes involved in de novo phospholipid biosynthesis, with muscular content of phosphatidylethanolamine and phosphatidylcholine, and with the content of subsarcolemmal lipid droplets. phosphatidylethanolamine 161-185 perilipin 4 Homo sapiens 10-15 25986609-2 2015 PE synthesis from ethanolamine and diacylglycerol is regulated primarily by CTP:phosphoethanolamine cytidylyltransferase (Pcyt2). phosphatidylethanolamine 0-2 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 76-120 25986609-2 2015 PE synthesis from ethanolamine and diacylglycerol is regulated primarily by CTP:phosphoethanolamine cytidylyltransferase (Pcyt2). phosphatidylethanolamine 0-2 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 122-127 25986609-3 2015 Pcyt2(+/-) mice have reduced PE synthesis and, as a consequence, perturbed glucose and fatty acid metabolism, which gradually leads to the development of hyperlipidemia, obesity, and insulin resistance. phosphatidylethanolamine 29-31 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 0-5 25980030-0 2015 The Biology and Disease Relevance of CD300a, an Inhibitory Receptor for Phosphatidylserine and Phosphatidylethanolamine. phosphatidylethanolamine 95-119 CD300a molecule Homo sapiens 37-43 25980030-4 2015 The finding that CD300a recognizes phosphatidylserine and phosphatidylethanolamine, two aminophospholipids exposed on the outer leaflet of dead and activated cells, has shed new light on its role in the modulation of immune functions and in its participation in the host response to several diseases states, such as infectious diseases, cancer, allergy, and chronic inflammatory diseases. phosphatidylethanolamine 58-82 CD300a molecule Homo sapiens 17-23 26020241-3 2015 Phospholipase D (PLD) is a phosphatidylcholine- and phosphatidylethanolamine-hydrolyzing enzyme that catalyzes the production of phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling in various organisms. phosphatidylethanolamine 52-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 26020241-3 2015 Phospholipase D (PLD) is a phosphatidylcholine- and phosphatidylethanolamine-hydrolyzing enzyme that catalyzes the production of phosphatidic acid (PA), a lipid second messenger that modulates diverse intracellular signaling in various organisms. phosphatidylethanolamine 52-76 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 25955207-4 2015 Muscle PtdEtn synthesis was disrupted by deleting CTP:phosphoethanolamine cytidylyltransferase (ECT), the rate-limiting enzyme in the CDP-ethanolamine pathway, a major route for PtdEtn production. phosphatidylethanolamine 7-13 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 50-94 25829489-2 2015 The mitochondrial enzyme that generates PE is phosphatidylserine decarboxylase 1 (Psd1p). phosphatidylethanolamine 40-42 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 46-80 25829489-2 2015 The mitochondrial enzyme that generates PE is phosphatidylserine decarboxylase 1 (Psd1p). phosphatidylethanolamine 40-42 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 82-87 25829489-3 2015 The pool of PE produced by Psd1p, which cannot be compensated for by the other cellular PE metabolic pathways, is important for numerous mitochondrial functions, including oxidative phosphorylation and mitochondrial dynamics and morphology, and is essential for murine development. phosphatidylethanolamine 12-14 psoriasis susceptibility 1 Mus musculus 27-32 25955207-4 2015 Muscle PtdEtn synthesis was disrupted by deleting CTP:phosphoethanolamine cytidylyltransferase (ECT), the rate-limiting enzyme in the CDP-ethanolamine pathway, a major route for PtdEtn production. phosphatidylethanolamine 7-13 cut-like homeobox 1 Mus musculus 134-137 25955207-4 2015 Muscle PtdEtn synthesis was disrupted by deleting CTP:phosphoethanolamine cytidylyltransferase (ECT), the rate-limiting enzyme in the CDP-ethanolamine pathway, a major route for PtdEtn production. phosphatidylethanolamine 178-184 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 50-94 25955207-4 2015 Muscle PtdEtn synthesis was disrupted by deleting CTP:phosphoethanolamine cytidylyltransferase (ECT), the rate-limiting enzyme in the CDP-ethanolamine pathway, a major route for PtdEtn production. phosphatidylethanolamine 178-184 cut-like homeobox 1 Mus musculus 134-137 25923686-1 2015 During autophagy, members of the ubiquitin-like Atg8 protein family get conjugated to phosphatidylethanolamine and act as protein-recruiting scaffolds on the autophagosomal membrane. phosphatidylethanolamine 86-110 GABA(A) receptor-associated protein like 2 L homeolog Xenopus laevis 48-52 25645919-4 2015 Atg8 is conjugated to phosphatidylethanolamine (PE) through a ubiquitin-like conjugation system to yield Atg8-PE; this reaction is called Atg8 lipidation. phosphatidylethanolamine 22-46 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 0-4 25645919-4 2015 Atg8 is conjugated to phosphatidylethanolamine (PE) through a ubiquitin-like conjugation system to yield Atg8-PE; this reaction is called Atg8 lipidation. phosphatidylethanolamine 22-46 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 105-109 25645919-4 2015 Atg8 is conjugated to phosphatidylethanolamine (PE) through a ubiquitin-like conjugation system to yield Atg8-PE; this reaction is called Atg8 lipidation. phosphatidylethanolamine 22-46 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 105-109 25645919-4 2015 Atg8 is conjugated to phosphatidylethanolamine (PE) through a ubiquitin-like conjugation system to yield Atg8-PE; this reaction is called Atg8 lipidation. phosphatidylethanolamine 48-50 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 0-4 25645919-4 2015 Atg8 is conjugated to phosphatidylethanolamine (PE) through a ubiquitin-like conjugation system to yield Atg8-PE; this reaction is called Atg8 lipidation. phosphatidylethanolamine 48-50 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 105-109 25645919-4 2015 Atg8 is conjugated to phosphatidylethanolamine (PE) through a ubiquitin-like conjugation system to yield Atg8-PE; this reaction is called Atg8 lipidation. phosphatidylethanolamine 48-50 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 105-109 25457203-8 2015 The disrupted VLDL assembly resulted in the secretion of enlarged, phosphatidylethanolamine-poor, TG- and apoE-enriched VLDL-particles; special features that lead to increased VLDL clearance and decreased serum TG levels. phosphatidylethanolamine 67-91 CD320 antigen Mus musculus 14-18 25680528-1 2015 The E2 enzyme Atg3 conjugates the ubiquitin-like protein Atg8 to phosphatidylethanolamine (PE) to drive autophagosome formation in Saccharomyces cerevisiae. phosphatidylethanolamine 65-89 Atg3p Saccharomyces cerevisiae S288C 14-18 25680528-1 2015 The E2 enzyme Atg3 conjugates the ubiquitin-like protein Atg8 to phosphatidylethanolamine (PE) to drive autophagosome formation in Saccharomyces cerevisiae. phosphatidylethanolamine 65-89 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 57-61 25680528-1 2015 The E2 enzyme Atg3 conjugates the ubiquitin-like protein Atg8 to phosphatidylethanolamine (PE) to drive autophagosome formation in Saccharomyces cerevisiae. phosphatidylethanolamine 91-93 Atg3p Saccharomyces cerevisiae S288C 14-18 25680528-1 2015 The E2 enzyme Atg3 conjugates the ubiquitin-like protein Atg8 to phosphatidylethanolamine (PE) to drive autophagosome formation in Saccharomyces cerevisiae. phosphatidylethanolamine 91-93 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 57-61 25680528-2 2015 In this study, we show that Atg3 localizes to the pre-autophagosomal structure (PAS) and the isolation membrane (IM), providing crucial evidence that Atg8-PE conjugates are produced on these structures. phosphatidylethanolamine 155-157 Atg3p Saccharomyces cerevisiae S288C 28-32 25680528-2 2015 In this study, we show that Atg3 localizes to the pre-autophagosomal structure (PAS) and the isolation membrane (IM), providing crucial evidence that Atg8-PE conjugates are produced on these structures. phosphatidylethanolamine 155-157 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 150-154 25461810-5 2015 Among these are the components of two ubiquitin-like conjugation reactions that collectively mediate the conjugation of the ubiquitin-like Atg12 to the Atg5 protein and of the ubiquitin-like protein Atg8 to the headgroup of the membrane lipid phosphatidylethanolamine. phosphatidylethanolamine 243-267 Atg12p Saccharomyces cerevisiae S288C 139-144 25461810-5 2015 Among these are the components of two ubiquitin-like conjugation reactions that collectively mediate the conjugation of the ubiquitin-like Atg12 to the Atg5 protein and of the ubiquitin-like protein Atg8 to the headgroup of the membrane lipid phosphatidylethanolamine. phosphatidylethanolamine 243-267 Atg5p Saccharomyces cerevisiae S288C 152-156 25461810-5 2015 Among these are the components of two ubiquitin-like conjugation reactions that collectively mediate the conjugation of the ubiquitin-like Atg12 to the Atg5 protein and of the ubiquitin-like protein Atg8 to the headgroup of the membrane lipid phosphatidylethanolamine. phosphatidylethanolamine 243-267 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 199-203 25571976-4 2015 Conversely, the artificial increase of intracellular PE levels, by provision of its precursor ethanolamine or by overexpression of the PE-generating enzyme Psd1, significantly increased autophagic flux, both in yeast and in mammalian cell culture. phosphatidylethanolamine 53-55 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 156-160 25601754-3 2015 Deacetylation of LC3 at K49 and K51 by Sirt1 allows LC3 to interact with the nuclear protein DOR and return to the cytoplasm with DOR, where it is able to bind Atg7 and other autophagy factors and undergo phosphatidylethanolamine conjugation to preautophagic membranes. phosphatidylethanolamine 205-229 microtubule associated protein 1 light chain 3 alpha Homo sapiens 17-20 25601754-3 2015 Deacetylation of LC3 at K49 and K51 by Sirt1 allows LC3 to interact with the nuclear protein DOR and return to the cytoplasm with DOR, where it is able to bind Atg7 and other autophagy factors and undergo phosphatidylethanolamine conjugation to preautophagic membranes. phosphatidylethanolamine 205-229 sirtuin 1 Homo sapiens 39-44 25601754-3 2015 Deacetylation of LC3 at K49 and K51 by Sirt1 allows LC3 to interact with the nuclear protein DOR and return to the cytoplasm with DOR, where it is able to bind Atg7 and other autophagy factors and undergo phosphatidylethanolamine conjugation to preautophagic membranes. phosphatidylethanolamine 205-229 microtubule associated protein 1 light chain 3 alpha Homo sapiens 52-55 25601754-3 2015 Deacetylation of LC3 at K49 and K51 by Sirt1 allows LC3 to interact with the nuclear protein DOR and return to the cytoplasm with DOR, where it is able to bind Atg7 and other autophagy factors and undergo phosphatidylethanolamine conjugation to preautophagic membranes. phosphatidylethanolamine 205-229 tumor protein p53 inducible nuclear protein 2 Homo sapiens 93-96 25601754-3 2015 Deacetylation of LC3 at K49 and K51 by Sirt1 allows LC3 to interact with the nuclear protein DOR and return to the cytoplasm with DOR, where it is able to bind Atg7 and other autophagy factors and undergo phosphatidylethanolamine conjugation to preautophagic membranes. phosphatidylethanolamine 205-229 tumor protein p53 inducible nuclear protein 2 Homo sapiens 130-133 25601754-3 2015 Deacetylation of LC3 at K49 and K51 by Sirt1 allows LC3 to interact with the nuclear protein DOR and return to the cytoplasm with DOR, where it is able to bind Atg7 and other autophagy factors and undergo phosphatidylethanolamine conjugation to preautophagic membranes. phosphatidylethanolamine 205-229 autophagy related 7 Homo sapiens 160-164 24837915-1 2014 Phosphatidylethanolamine and glucose were added to the degummed mustard seed oil (20.16mumol/g oil) to prepare blank oil (O), glucose added oil (OG), phosphatidylethanolamine added oil (OP), and both phosphatidylethanolamine and glucose added oil (OPG). phosphatidylethanolamine 0-24 basic transcription factor 3 pseudogene 11 Homo sapiens 248-251 25646086-5 2015 As judged by biochemical and phenotypic criteria, a mutant (Fpk1(11A)), in which 11 sites were mutated to Ala, was hyperactive, causing increased inward transport of phosphatidylethanolamine. phosphatidylethanolamine 166-190 serine/threonine protein kinase FPK1 Saccharomyces cerevisiae S288C 60-64 25519895-3 2015 The formation of these double-membrane vesicles requires the covalent conjugation of the ubiquitin-like protein Atg8 to phosphatidylethanolamine (PE). phosphatidylethanolamine 120-144 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 112-116 25519895-3 2015 The formation of these double-membrane vesicles requires the covalent conjugation of the ubiquitin-like protein Atg8 to phosphatidylethanolamine (PE). phosphatidylethanolamine 146-148 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 112-116 25519895-6 2015 MCD4 encodes an ethanolamine phosphate transferase that uses PE as a precursor for an essential step in the synthesis of the glycosylphosphatidylinositol (GPI) anchor used to link a subset of plasma membrane proteins to lipid bilayers. phosphatidylethanolamine 61-63 mannose-ethanolamine phosphotransferase MCD4 Saccharomyces cerevisiae S288C 0-4 30154994-3 2015 Here we report that the cationic protein Cyt-c is also able to interact electrostatically with the main lipid components of the mitochondrial membranes, the zwitterionic lipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE), through the mediation of phosphate anions that bind specifically to amino groups in the surfaces of protein and model membranes. phosphatidylethanolamine 206-230 cytochrome c, somatic Homo sapiens 41-46 30154994-3 2015 Here we report that the cationic protein Cyt-c is also able to interact electrostatically with the main lipid components of the mitochondrial membranes, the zwitterionic lipids phosphatidylcholine (PC) and phosphatidylethanolamine (PE), through the mediation of phosphate anions that bind specifically to amino groups in the surfaces of protein and model membranes. phosphatidylethanolamine 232-234 cytochrome c, somatic Homo sapiens 41-46 30154994-6 2015 Based on these results, we postulate that the rise of H2O2 concentrations to the submillimolar levels registered during initiation of the apoptotic program may represent one signaling event that triggers the gain in peroxidatic function of the Cyt-c molecules bound to the abundant PE and PC membrane components. phosphatidylethanolamine 282-284 cytochrome c, somatic Homo sapiens 244-249 25519895-9 2015 Quantitative lipid analysis revealed that PE levels are substantially reduced in the mcd4-174 mutant but can be restored by deletion of ATG7 or CHO2. phosphatidylethanolamine 42-44 mannose-ethanolamine phosphotransferase MCD4 Saccharomyces cerevisiae S288C 85-89 25519895-9 2015 Quantitative lipid analysis revealed that PE levels are substantially reduced in the mcd4-174 mutant but can be restored by deletion of ATG7 or CHO2. phosphatidylethanolamine 42-44 Atg7p Saccharomyces cerevisiae S288C 136-140 25519895-9 2015 Quantitative lipid analysis revealed that PE levels are substantially reduced in the mcd4-174 mutant but can be restored by deletion of ATG7 or CHO2. phosphatidylethanolamine 42-44 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 144-148 25490467-6 2015 RESULTS: We demonstrate that the C-terminal part of Vif interacts directly with LC3B, independently of the presence of APOBEC3G.Vif binds to pro-LC3 and autophagy-related protein 4-cleaved LC3 forms, and glycine 120, the amino acid conjugated to phosphatidylethanolamine on autophagosomes, is required. phosphatidylethanolamine 246-270 microtubule associated protein 1 light chain 3 beta Homo sapiens 80-84 26480301-1 2014 We recently reported that knocking down the enzyme phosphatidylserine decarboxylase, which synthesizes the phospholipid phosphatidylethanolamine (PE) in mitochondria, perturbs the homeostasis of the human Parkinson disease (PD) protein alpha-synuclein (expressed in yeast or worms). phosphatidylethanolamine 120-144 synuclein alpha Homo sapiens 236-251 26480301-1 2014 We recently reported that knocking down the enzyme phosphatidylserine decarboxylase, which synthesizes the phospholipid phosphatidylethanolamine (PE) in mitochondria, perturbs the homeostasis of the human Parkinson disease (PD) protein alpha-synuclein (expressed in yeast or worms). phosphatidylethanolamine 146-148 synuclein alpha Homo sapiens 236-251 25378585-2 2015 In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine. phosphatidylethanolamine 121-145 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 57-61 25378585-2 2015 In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine. phosphatidylethanolamine 121-145 aminophospholipid-translocating P4-type ATPase DNF2 Saccharomyces cerevisiae S288C 63-67 25378585-2 2015 In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine. phosphatidylethanolamine 121-145 aminophospholipid-translocating P4-type ATPase DNF3 Saccharomyces cerevisiae S288C 69-73 25378585-2 2015 In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine. phosphatidylethanolamine 121-145 aminophospholipid-translocating P4-type ATPase DRS2 Saccharomyces cerevisiae S288C 75-79 25378585-2 2015 In Saccharomyces cerevisiae, five related gene products (Dnf1, Dnf2, Dnf3, Drs2, and Neo1) are implicated in flipping of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine. phosphatidylethanolamine 121-145 putative aminophospholipid-translocating P4-type ATPase NEO1 Saccharomyces cerevisiae S288C 85-89 25671705-4 2015 CNEP-1(Nem1) is an activator of lipin(Pah1), which is the key phosphatidic acid phosphatase that regulates the metabolic branch-point between the production of phosphatidylinositol (PtdIns) and major membrane phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE). phosphatidylethanolamine 253-277 tropomyosin 3 Homo sapiens 7-11 25671705-4 2015 CNEP-1(Nem1) is an activator of lipin(Pah1), which is the key phosphatidic acid phosphatase that regulates the metabolic branch-point between the production of phosphatidylinositol (PtdIns) and major membrane phospholipids, phosphatidylcholine (PC) and phosphatidylethanolamine (PE). phosphatidylethanolamine 279-281 tropomyosin 3 Homo sapiens 7-11 25315773-5 2014 We found that ATP11A and ATP11C have flippase activities toward phosphatidylserine and phosphatidylethanolamine but not PC or sphingomyelin. phosphatidylethanolamine 87-111 ATPase phospholipid transporting 11A Homo sapiens 14-20 25315773-5 2014 We found that ATP11A and ATP11C have flippase activities toward phosphatidylserine and phosphatidylethanolamine but not PC or sphingomyelin. phosphatidylethanolamine 87-111 ATPase phospholipid transporting 11C Homo sapiens 25-31 25396754-8 2014 Remarkably, we found that the phenotype of quiescent liver tissue from E2F2-/- mice resembles the phenotype of proliferating E2F2+/+ liver tissue, characterized by a decreased phosphatidylcholine to phosphatidylethanolamine ratio and a reprogramming of genes involved in generation of choline and ethanolamine derivatives. phosphatidylethanolamine 199-223 E2F transcription factor 2 Mus musculus 71-75 25396754-8 2014 Remarkably, we found that the phenotype of quiescent liver tissue from E2F2-/- mice resembles the phenotype of proliferating E2F2+/+ liver tissue, characterized by a decreased phosphatidylcholine to phosphatidylethanolamine ratio and a reprogramming of genes involved in generation of choline and ethanolamine derivatives. phosphatidylethanolamine 199-223 E2F transcription factor 2 Mus musculus 125-129 25177326-9 2014 Furthermore, Atg8, which displayed high sequence identity with its yeast homolog, was able to conjugate to phosphatidylethanolamine (PE) in vitro and was recruited to the phagophore assembly site in yeast. phosphatidylethanolamine 107-131 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 13-17 24763848-3 2014 Raf kinase inhibitor protein is a member of an evolutionarily conserved group of proteins called phosphatidylethanolamine-binding proteins. phosphatidylethanolamine 97-121 phosphatidylethanolamine binding protein 1 Homo sapiens 0-28 24996626-4 2014 ATG4 processes ATG8 precursor to expose its C-terminal glycine for phosphatidyl ethanolamine (PE) lipidation. phosphatidylethanolamine 67-92 cysteine protease ATG4B Triticum aestivum 0-4 24996626-4 2014 ATG4 processes ATG8 precursor to expose its C-terminal glycine for phosphatidyl ethanolamine (PE) lipidation. phosphatidylethanolamine 67-92 autophagy-related protein 8A Triticum aestivum 15-19 24996626-4 2014 ATG4 processes ATG8 precursor to expose its C-terminal glycine for phosphatidyl ethanolamine (PE) lipidation. phosphatidylethanolamine 94-96 cysteine protease ATG4B Triticum aestivum 0-4 24996626-4 2014 ATG4 processes ATG8 precursor to expose its C-terminal glycine for phosphatidyl ethanolamine (PE) lipidation. phosphatidylethanolamine 94-96 autophagy-related protein 8A Triticum aestivum 15-19 24276246-9 2014 Moreover, we found that hPEBP4 functioned as a scaffolding molecule and enhanced the association of Akt with Src to promote Akt tyrosine phosphorylation, a prerequisite for the full activation of Akt, in a phosphatidylethanolamine-binding domain-dependent manner. phosphatidylethanolamine 206-230 phosphatidylethanolamine binding protein 4 Homo sapiens 24-30 24276246-9 2014 Moreover, we found that hPEBP4 functioned as a scaffolding molecule and enhanced the association of Akt with Src to promote Akt tyrosine phosphorylation, a prerequisite for the full activation of Akt, in a phosphatidylethanolamine-binding domain-dependent manner. phosphatidylethanolamine 206-230 AKT serine/threonine kinase 1 Homo sapiens 100-103 24276246-9 2014 Moreover, we found that hPEBP4 functioned as a scaffolding molecule and enhanced the association of Akt with Src to promote Akt tyrosine phosphorylation, a prerequisite for the full activation of Akt, in a phosphatidylethanolamine-binding domain-dependent manner. phosphatidylethanolamine 206-230 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 109-112 25181299-1 2014 Atg8 modifier in yeast is conjugated to phosphatidylethanolamine via ubiquitylation-like reactions essential for autophagy. phosphatidylethanolamine 40-64 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 0-4 25181299-6 2014 Finally, Atg8 homologs are conjugated to phospholipids, phosphatidylethanolamine, and phosphatidylserine. phosphatidylethanolamine 56-80 GABA type A receptor associated protein like 2 Homo sapiens 9-13 25183817-1 2014 Following autophagy induction, the autophagy-related protein Atg8 undergoes ubiquitin-like conjugation to phosphatidylethanolamine and inserts into the autophagosome membrane. phosphatidylethanolamine 106-130 Autophagy-related 8a Drosophila melanogaster 61-65 24906800-4 2014 Loss of the phospholipid methyltransferase Cho2p, which showed the strongest impact on mRNA localization, disturbs mRNA localization, as well as ER morphology and segregation, owing to an increase in the amount of cellular phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 223-247 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 43-48 24906800-4 2014 Loss of the phospholipid methyltransferase Cho2p, which showed the strongest impact on mRNA localization, disturbs mRNA localization, as well as ER morphology and segregation, owing to an increase in the amount of cellular phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 249-255 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 43-48 24785657-7 2014 The formation of GFP-LC3 (light chain 3) punctae and PE (phosphatidylethanolamine)-conjugated LC3 (LC3-II) in serum-starved cells was inhibited by NRBF2 knockdown in the absence and presence of lysosomal inhibitors, and p62 levels were increased. phosphatidylethanolamine 57-81 microtubule associated protein 1 light chain 3 alpha Homo sapiens 94-97 24785657-7 2014 The formation of GFP-LC3 (light chain 3) punctae and PE (phosphatidylethanolamine)-conjugated LC3 (LC3-II) in serum-starved cells was inhibited by NRBF2 knockdown in the absence and presence of lysosomal inhibitors, and p62 levels were increased. phosphatidylethanolamine 57-81 microtubule associated protein 1 light chain 3 alpha Homo sapiens 99-105 24785657-7 2014 The formation of GFP-LC3 (light chain 3) punctae and PE (phosphatidylethanolamine)-conjugated LC3 (LC3-II) in serum-starved cells was inhibited by NRBF2 knockdown in the absence and presence of lysosomal inhibitors, and p62 levels were increased. phosphatidylethanolamine 57-81 nuclear receptor binding factor 2 Homo sapiens 147-152 24963637-6 2014 By reconstituting the conjugation of Atg8 to membranes in vitro, we showed that after Atg8 has been attached to phosphatidylethanolamine (PE), it recruits Atg12-Atg5 to membranes by recognizing a noncanonical Atg8-interacting motif (AIM) within Atg12. phosphatidylethanolamine 112-136 GABA type A receptor associated protein like 1 Homo sapiens 37-41 24963637-6 2014 By reconstituting the conjugation of Atg8 to membranes in vitro, we showed that after Atg8 has been attached to phosphatidylethanolamine (PE), it recruits Atg12-Atg5 to membranes by recognizing a noncanonical Atg8-interacting motif (AIM) within Atg12. phosphatidylethanolamine 112-136 GABA type A receptor associated protein like 1 Homo sapiens 86-90 24963637-6 2014 By reconstituting the conjugation of Atg8 to membranes in vitro, we showed that after Atg8 has been attached to phosphatidylethanolamine (PE), it recruits Atg12-Atg5 to membranes by recognizing a noncanonical Atg8-interacting motif (AIM) within Atg12. phosphatidylethanolamine 112-136 autophagy related 12 Homo sapiens 155-160 24963637-6 2014 By reconstituting the conjugation of Atg8 to membranes in vitro, we showed that after Atg8 has been attached to phosphatidylethanolamine (PE), it recruits Atg12-Atg5 to membranes by recognizing a noncanonical Atg8-interacting motif (AIM) within Atg12. phosphatidylethanolamine 112-136 autophagy related 5 Homo sapiens 161-165 24963637-6 2014 By reconstituting the conjugation of Atg8 to membranes in vitro, we showed that after Atg8 has been attached to phosphatidylethanolamine (PE), it recruits Atg12-Atg5 to membranes by recognizing a noncanonical Atg8-interacting motif (AIM) within Atg12. phosphatidylethanolamine 112-136 GABA type A receptor associated protein like 1 Homo sapiens 86-90 24963637-6 2014 By reconstituting the conjugation of Atg8 to membranes in vitro, we showed that after Atg8 has been attached to phosphatidylethanolamine (PE), it recruits Atg12-Atg5 to membranes by recognizing a noncanonical Atg8-interacting motif (AIM) within Atg12. phosphatidylethanolamine 112-136 autophagy related 12 Homo sapiens 245-250 24963637-6 2014 By reconstituting the conjugation of Atg8 to membranes in vitro, we showed that after Atg8 has been attached to phosphatidylethanolamine (PE), it recruits Atg12-Atg5 to membranes by recognizing a noncanonical Atg8-interacting motif (AIM) within Atg12. phosphatidylethanolamine 138-140 GABA type A receptor associated protein like 1 Homo sapiens 37-41 24963637-6 2014 By reconstituting the conjugation of Atg8 to membranes in vitro, we showed that after Atg8 has been attached to phosphatidylethanolamine (PE), it recruits Atg12-Atg5 to membranes by recognizing a noncanonical Atg8-interacting motif (AIM) within Atg12. phosphatidylethanolamine 138-140 GABA type A receptor associated protein like 1 Homo sapiens 86-90 24963637-6 2014 By reconstituting the conjugation of Atg8 to membranes in vitro, we showed that after Atg8 has been attached to phosphatidylethanolamine (PE), it recruits Atg12-Atg5 to membranes by recognizing a noncanonical Atg8-interacting motif (AIM) within Atg12. phosphatidylethanolamine 138-140 autophagy related 12 Homo sapiens 155-160 24963637-6 2014 By reconstituting the conjugation of Atg8 to membranes in vitro, we showed that after Atg8 has been attached to phosphatidylethanolamine (PE), it recruits Atg12-Atg5 to membranes by recognizing a noncanonical Atg8-interacting motif (AIM) within Atg12. phosphatidylethanolamine 138-140 autophagy related 5 Homo sapiens 161-165 24963637-6 2014 By reconstituting the conjugation of Atg8 to membranes in vitro, we showed that after Atg8 has been attached to phosphatidylethanolamine (PE), it recruits Atg12-Atg5 to membranes by recognizing a noncanonical Atg8-interacting motif (AIM) within Atg12. phosphatidylethanolamine 138-140 GABA type A receptor associated protein like 1 Homo sapiens 86-90 24963637-6 2014 By reconstituting the conjugation of Atg8 to membranes in vitro, we showed that after Atg8 has been attached to phosphatidylethanolamine (PE), it recruits Atg12-Atg5 to membranes by recognizing a noncanonical Atg8-interacting motif (AIM) within Atg12. phosphatidylethanolamine 138-140 autophagy related 12 Homo sapiens 245-250 24802409-1 2014 CTP:phosphoethanolamine cytidylyltransferase (ECT) is a key enzyme in the CDP-ethanolamine branch of the Kennedy pathway, which is the primary pathway of phosphatidylethanolamine (PE) synthesis in mammalian cells. phosphatidylethanolamine 154-178 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 0-44 24802409-1 2014 CTP:phosphoethanolamine cytidylyltransferase (ECT) is a key enzyme in the CDP-ethanolamine branch of the Kennedy pathway, which is the primary pathway of phosphatidylethanolamine (PE) synthesis in mammalian cells. phosphatidylethanolamine 154-178 ECT Homo sapiens 46-49 24802409-1 2014 CTP:phosphoethanolamine cytidylyltransferase (ECT) is a key enzyme in the CDP-ethanolamine branch of the Kennedy pathway, which is the primary pathway of phosphatidylethanolamine (PE) synthesis in mammalian cells. phosphatidylethanolamine 180-182 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 0-44 24802409-1 2014 CTP:phosphoethanolamine cytidylyltransferase (ECT) is a key enzyme in the CDP-ethanolamine branch of the Kennedy pathway, which is the primary pathway of phosphatidylethanolamine (PE) synthesis in mammalian cells. phosphatidylethanolamine 180-182 ECT Homo sapiens 46-49 24802409-6 2014 Overexpression of the wild-type hECT and hECT mutants containing amino acid substitutions in the HxGH motif in the C-terminal CT domain suppressed the growth defect of the Saccharomyces cerevisiae mutant of ECT1 encoding ECT in the absence of a PE supply via the decarboxylation of phosphatidylserine, but overexpression of hECT mutants of the N-terminal CT domain did not. phosphatidylethanolamine 245-247 ECT Homo sapiens 32-36 24802409-6 2014 Overexpression of the wild-type hECT and hECT mutants containing amino acid substitutions in the HxGH motif in the C-terminal CT domain suppressed the growth defect of the Saccharomyces cerevisiae mutant of ECT1 encoding ECT in the absence of a PE supply via the decarboxylation of phosphatidylserine, but overexpression of hECT mutants of the N-terminal CT domain did not. phosphatidylethanolamine 245-247 ECT Homo sapiens 41-45 24802409-6 2014 Overexpression of the wild-type hECT and hECT mutants containing amino acid substitutions in the HxGH motif in the C-terminal CT domain suppressed the growth defect of the Saccharomyces cerevisiae mutant of ECT1 encoding ECT in the absence of a PE supply via the decarboxylation of phosphatidylserine, but overexpression of hECT mutants of the N-terminal CT domain did not. phosphatidylethanolamine 245-247 ethanolamine-phosphate cytidylyltransferase Saccharomyces cerevisiae S288C 207-211 24802409-6 2014 Overexpression of the wild-type hECT and hECT mutants containing amino acid substitutions in the HxGH motif in the C-terminal CT domain suppressed the growth defect of the Saccharomyces cerevisiae mutant of ECT1 encoding ECT in the absence of a PE supply via the decarboxylation of phosphatidylserine, but overexpression of hECT mutants of the N-terminal CT domain did not. phosphatidylethanolamine 245-247 ECT Homo sapiens 33-36 24802409-6 2014 Overexpression of the wild-type hECT and hECT mutants containing amino acid substitutions in the HxGH motif in the C-terminal CT domain suppressed the growth defect of the Saccharomyces cerevisiae mutant of ECT1 encoding ECT in the absence of a PE supply via the decarboxylation of phosphatidylserine, but overexpression of hECT mutants of the N-terminal CT domain did not. phosphatidylethanolamine 245-247 ECT Homo sapiens 41-45 25233411-4 2014 Autophagosome formation in animals is crucially dependent on the unique conjugation of a group of ubiquitin-like proteins in the microtubule-associated proteins 1A/1B light chain 3 (LC3) family to the headgroup of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 214-238 microtubule associated protein 1 light chain 3 alpha Homo sapiens 129-180 25233411-4 2014 Autophagosome formation in animals is crucially dependent on the unique conjugation of a group of ubiquitin-like proteins in the microtubule-associated proteins 1A/1B light chain 3 (LC3) family to the headgroup of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 214-238 microtubule associated protein 1 light chain 3 alpha Homo sapiens 182-185 25233411-4 2014 Autophagosome formation in animals is crucially dependent on the unique conjugation of a group of ubiquitin-like proteins in the microtubule-associated proteins 1A/1B light chain 3 (LC3) family to the headgroup of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 240-242 microtubule associated protein 1 light chain 3 alpha Homo sapiens 129-180 25233411-4 2014 Autophagosome formation in animals is crucially dependent on the unique conjugation of a group of ubiquitin-like proteins in the microtubule-associated proteins 1A/1B light chain 3 (LC3) family to the headgroup of phosphatidylethanolamine (PE) lipids. phosphatidylethanolamine 240-242 microtubule associated protein 1 light chain 3 alpha Homo sapiens 182-185 24992464-2 2014 PS is synthesized from phosphatidylcholine or phosphatidylethanolamine by exchanging the base head group with serine, and this reaction is catalyzed by phosphatidylserine synthase 1 and phosphatidylserine synthase 2 located in the endoplasmic reticulum. phosphatidylethanolamine 46-70 phosphatidylserine synthase 2 Homo sapiens 186-215 24677714-6 2014 Mitochondrial PC levels were lower and PE levels were higher in livers from Pemt(-/-) compared with Pemt(+/+) mice, resulting in a 33% reduction of the PC-to-PE ratio. phosphatidylethanolamine 158-160 phosphatidylethanolamine N-methyltransferase Mus musculus 76-80 24677714-10 2014 We observed a strong correlation between mitochondrial PC-to-PE ratio and cellular ATP levels in hepatoma cells that expressed various amounts of PEMT. phosphatidylethanolamine 61-63 phosphatidylethanolamine N-methyltransferase Mus musculus 146-150 24910243-6 2014 PLA2G2E altered minor lipoprotein phospholipids, phosphatidylserine and phosphatidylethanolamine, and moderately facilitated lipid accumulation in adipose tissue and liver. phosphatidylethanolamine 72-96 phospholipase A2, group IIE Mus musculus 0-7 24821075-0 2014 PE-induced apoptosis in SMMC-7721 cells: involvement of Erk and Stat signalling pathways. phosphatidylethanolamine 0-2 mitogen-activated protein kinase 1 Homo sapiens 56-59 24821075-0 2014 PE-induced apoptosis in SMMC-7721 cells: involvement of Erk and Stat signalling pathways. phosphatidylethanolamine 0-2 signal transducer and activator of transcription 1 Homo sapiens 64-68 24821075-9 2014 PE-induced apoptosis was accompanied by a decrease in Erk phospho-rylation and by the activation of Stat1/2 phosphorylation in SMMC-7721 cells. phosphatidylethanolamine 0-2 mitogen-activated protein kinase 1 Homo sapiens 54-57 24821075-9 2014 PE-induced apoptosis was accompanied by a decrease in Erk phospho-rylation and by the activation of Stat1/2 phosphorylation in SMMC-7721 cells. phosphatidylethanolamine 0-2 signal transducer and activator of transcription 1 Homo sapiens 100-107 24821075-10 2014 In conclusion, the results suggested that PE-induced apoptosis is involved in upregulating the Bax/Bcl-2 protein ratio and decreasing the DeltaPsim. phosphatidylethanolamine 42-44 BCL2 associated X, apoptosis regulator Homo sapiens 95-98 24821075-10 2014 In conclusion, the results suggested that PE-induced apoptosis is involved in upregulating the Bax/Bcl-2 protein ratio and decreasing the DeltaPsim. phosphatidylethanolamine 42-44 BCL2 apoptosis regulator Homo sapiens 99-104 24821075-11 2014 Moreover, the results showed that the Erk and Stat1/2 signalling pathways may be involved in the process of PE-induced apoptosis. phosphatidylethanolamine 108-110 mitogen-activated protein kinase 1 Homo sapiens 38-41 24821075-11 2014 Moreover, the results showed that the Erk and Stat1/2 signalling pathways may be involved in the process of PE-induced apoptosis. phosphatidylethanolamine 108-110 signal transducer and activator of transcription 1 Homo sapiens 46-53 25177326-9 2014 Furthermore, Atg8, which displayed high sequence identity with its yeast homolog, was able to conjugate to phosphatidylethanolamine (PE) in vitro and was recruited to the phagophore assembly site in yeast. phosphatidylethanolamine 133-135 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 13-17 24184426-1 2014 Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 95-119 methionine adenosyltransferase I, alpha Mus musculus 180-186 24703999-1 2014 CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) has an important regulatory function in biosynthesis of the membrane phospholipid phosphatidylethanolamine. phosphatidylethanolamine 135-159 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 0-44 24703999-1 2014 CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) has an important regulatory function in biosynthesis of the membrane phospholipid phosphatidylethanolamine. phosphatidylethanolamine 135-159 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 46-51 24184426-1 2014 Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 95-119 phosphatidylethanolamine N-methyltransferase Mus musculus 200-244 24184426-1 2014 Phosphatidylcholine is made in the liver via the CDP-choline pathway and via the conversion of phosphatidylethanolamine to phosphatidylcholine by 3 transmethylation reactions from AdoMet catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 95-119 phosphatidylethanolamine N-methyltransferase Mus musculus 246-250 24184426-4 2014 PEMT activity is regulated by the concentration of substrates (phosphatidylethanolamine and AdoMet) as well as the ratio of AdoMet to AdoHcy. phosphatidylethanolamine 63-87 phosphatidylethanolamine N-methyltransferase Mus musculus 0-4 24658121-3 2014 Conjugation of PE to Atg8 requires processing of the C-terminal conserved glycine residue in Atg8 by the Atg4 cysteine protease. phosphatidylethanolamine 15-17 UbiA prenyltransferase family protein Arabidopsis thaliana 105-109 25076779-2 2014 The precursor protein of HCNP (HCNP-pp), composed of 186 amino acids, is a multifunctional protein, such as c-Raf kinase inhibitory protein and phosphatidylethanolamine-binding protein. phosphatidylethanolamine 144-168 phosphatidylethanolamine binding protein 1 Mus musculus 31-38 24821794-6 2014 The dATP8B locus encodes a member of the P4-type ATPase family thought to flip aminophospholipids such as phosphatidylserine and phosphatidylethanolamine from one membrane leaflet to the other. phosphatidylethanolamine 129-153 ATPase 8B Drosophila melanogaster 4-10 24735444-3 2014 ATG4B also cleaves phosphatidylethanolamine (PE) from LC3-II to regenerate LC3-I, enabling its recycling for further membrane biogenesis. phosphatidylethanolamine 19-43 autophagy related 4B cysteine peptidase Homo sapiens 0-5 24803661-0 2014 Lipocalin 2 binds to membrane phosphatidylethanolamine to induce lipid raft movement in a PKA-dependent manner and modulates sperm maturation. phosphatidylethanolamine 30-54 lipocalin 2 Homo sapiens 0-11 24803661-4 2014 Furthermore, we found that LCN2 binds to membrane phosphatidylethanolamine to reinforce lipid raft reorganization via a PKA-dependent mechanism and promotes sperm to acquire fertility by facilitating cholesterol efflux. phosphatidylethanolamine 50-74 lipocalin 2 Homo sapiens 27-31 24648496-3 2014 Mutants defective in MET regulon repression reveal that loss of Cho2, which is required for the methylation of phosphatidylethanolamine to produce phosphatidylcholine, leads to induction of the MET regulon. phosphatidylethanolamine 111-135 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 64-68 24316057-5 2014 In mammalian cells, formation of these contact sites between MAM and mitochondria appears to be required for key cellular events including the transport of calcium from the ER to mitochondria, the import of phosphatidylserine into mitochondria from the ER for decarboxylation to phosphatidylethanolamine, the formation of autophagosomes, regulation of the morphology, dynamics and functions of mitochondria, and cell survival. phosphatidylethanolamine 279-303 sarcoglycan gamma Homo sapiens 61-64 24519946-1 2014 CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) is the main regulatory enzyme for de novo biosynthesis of phosphatidylethanolamine by the CDP-ethanolamine pathway. phosphatidylethanolamine 111-135 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 0-44 24519946-1 2014 CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) is the main regulatory enzyme for de novo biosynthesis of phosphatidylethanolamine by the CDP-ethanolamine pathway. phosphatidylethanolamine 111-135 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 46-51 24519946-7 2014 Single and double mutations of PKC consensus sites reduced Pcyt2alpha phosphorylation, activity, and phosphatidylethanolamine synthesis by 50-90%. phosphatidylethanolamine 101-125 protein kinase C alpha Homo sapiens 31-34 24735444-3 2014 ATG4B also cleaves phosphatidylethanolamine (PE) from LC3-II to regenerate LC3-I, enabling its recycling for further membrane biogenesis. phosphatidylethanolamine 45-47 autophagy related 4B cysteine peptidase Homo sapiens 0-5 24413923-2 2014 At the last step of the LC3 lipidation cascade, LC3 is transferred from the E2 enzyme ATG3 to phosphatidylethanolamine (PE). phosphatidylethanolamine 94-118 microtubule associated protein 1 light chain 3 alpha Homo sapiens 24-27 24667182-1 2014 Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. phosphatidylethanolamine 81-105 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 24667182-1 2014 Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. phosphatidylethanolamine 81-105 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 24667182-1 2014 Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. phosphatidylethanolamine 107-109 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 24667182-1 2014 Phosphatidylethanolamine N-methyltransferase (Pemt) catalyzes the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) mainly in the liver. phosphatidylethanolamine 107-109 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 24667182-2 2014 Under an obese state, the upregulation of Pemt induces endoplasmic reticulum (ER) stress by increasing the PC/PE ratio in the liver. phosphatidylethanolamine 110-112 phosphatidylethanolamine N-methyltransferase Mus musculus 42-46 24413923-2 2014 At the last step of the LC3 lipidation cascade, LC3 is transferred from the E2 enzyme ATG3 to phosphatidylethanolamine (PE). phosphatidylethanolamine 94-118 microtubule associated protein 1 light chain 3 alpha Homo sapiens 48-51 24413923-2 2014 At the last step of the LC3 lipidation cascade, LC3 is transferred from the E2 enzyme ATG3 to phosphatidylethanolamine (PE). phosphatidylethanolamine 94-118 autophagy related 3 Homo sapiens 86-90 24413923-2 2014 At the last step of the LC3 lipidation cascade, LC3 is transferred from the E2 enzyme ATG3 to phosphatidylethanolamine (PE). phosphatidylethanolamine 120-122 microtubule associated protein 1 light chain 3 alpha Homo sapiens 24-27 24413923-2 2014 At the last step of the LC3 lipidation cascade, LC3 is transferred from the E2 enzyme ATG3 to phosphatidylethanolamine (PE). phosphatidylethanolamine 120-122 microtubule associated protein 1 light chain 3 alpha Homo sapiens 48-51 24413923-2 2014 At the last step of the LC3 lipidation cascade, LC3 is transferred from the E2 enzyme ATG3 to phosphatidylethanolamine (PE). phosphatidylethanolamine 120-122 autophagy related 3 Homo sapiens 86-90 24325630-1 2014 In this study, transferrin (Tf)-modified poly(ethylene glycol)-phosphatidylethanolamine (mPEG-PE) micelles loaded with the poorly water-soluble drug, R547 (a potent and selective ATP-competitive cyclin-dependent kinase (CDK) inhibitor), were prepared and evaluated for their targeting efficiency and cytotoxicity in vitro and in vivo to A2780 ovarian carcinoma cells, which overexpress transferrin receptors (TfR). phosphatidylethanolamine 63-87 transferrin Mus musculus 15-26 24413176-2 2014 In the retina, ATP8A2 is localized in photoreceptors where it uses ATP to transport phosphatidylserine (PS) and phosphatidylethanolamine (PE) from the exoplasmic to the cytoplasmic leaflet of membranes. phosphatidylethanolamine 112-136 ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 Mus musculus 15-21 24413176-2 2014 In the retina, ATP8A2 is localized in photoreceptors where it uses ATP to transport phosphatidylserine (PS) and phosphatidylethanolamine (PE) from the exoplasmic to the cytoplasmic leaflet of membranes. phosphatidylethanolamine 138-140 ATPase, aminophospholipid transporter-like, class I, type 8A, member 2 Mus musculus 15-21 24368431-2 2014 In mammals, choline is synthesized via phosphatidylethanolamine N-methyltransferase (Pemt), which converts phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 39-63 phosphatidylethanolamine N-methyltransferase Mus musculus 85-89 24391008-2 2013 Among these genes, ATG8 encodes a ubiquitin-like protein that is conjugated to a phosphatidylethanolamine (PE) membrane by the ubiquitination system. phosphatidylethanolamine 81-105 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 19-23 24485455-2 2014 A key step in the pathway is the covalent conjugation of the ubiquitin-related protein Atg8 to phosphatidylethanolamine (Atg8-PE) in autophagic membranes by a complex consisting of Atg16 and the Atg12-Atg5 conjugate. phosphatidylethanolamine 95-119 GABA type A receptor associated protein like 1 Homo sapiens 87-91 24753818-1 2014 Previously, we reported that lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, can increase intracellular Ca(2+) ([Ca(2+)]i) via type 1 lysophosphatidic acid (LPA) receptor (LPA1) and CD97, an adhesion G-protein-coupled receptor (GPCR), in MDA-MB-231 breast cancer cells. phosphatidylethanolamine 33-57 lysophosphatidic acid receptor 1 Homo sapiens 212-216 24753818-1 2014 Previously, we reported that lysophosphatidylethanolamine (LPE), a lyso-type metabolite of phosphatidylethanolamine, can increase intracellular Ca(2+) ([Ca(2+)]i) via type 1 lysophosphatidic acid (LPA) receptor (LPA1) and CD97, an adhesion G-protein-coupled receptor (GPCR), in MDA-MB-231 breast cancer cells. phosphatidylethanolamine 33-57 adhesion G protein-coupled receptor E5 Homo sapiens 222-226 24485455-2 2014 A key step in the pathway is the covalent conjugation of the ubiquitin-related protein Atg8 to phosphatidylethanolamine (Atg8-PE) in autophagic membranes by a complex consisting of Atg16 and the Atg12-Atg5 conjugate. phosphatidylethanolamine 95-119 GABA type A receptor associated protein like 1 Homo sapiens 121-125 24485455-2 2014 A key step in the pathway is the covalent conjugation of the ubiquitin-related protein Atg8 to phosphatidylethanolamine (Atg8-PE) in autophagic membranes by a complex consisting of Atg16 and the Atg12-Atg5 conjugate. phosphatidylethanolamine 95-119 autophagy related 12 Homo sapiens 195-200 24485455-2 2014 A key step in the pathway is the covalent conjugation of the ubiquitin-related protein Atg8 to phosphatidylethanolamine (Atg8-PE) in autophagic membranes by a complex consisting of Atg16 and the Atg12-Atg5 conjugate. phosphatidylethanolamine 95-119 autophagy related 5 Homo sapiens 201-205 24466199-4 2014 Atg5 is part of a protein complex that facilitates the transfer of the ubiquitin-like protein Atg8 from the E2-like conjugation enzyme Atg3 to the lipid phosphatidylethanolamine. phosphatidylethanolamine 153-177 autophagy related 5 Mus musculus 0-4 24466199-4 2014 Atg5 is part of a protein complex that facilitates the transfer of the ubiquitin-like protein Atg8 from the E2-like conjugation enzyme Atg3 to the lipid phosphatidylethanolamine. phosphatidylethanolamine 153-177 autophagy related 3 Mus musculus 135-139 24333423-10 2014 Cholesterol had the opposite effect on the HAS2 activity in liposomes composed of phosphatidylethanolamine or phosphatidylserine. phosphatidylethanolamine 82-106 hyaluronan synthase 2 Homo sapiens 43-47 23988655-3 2014 In addition, LC/MS lipidomics analysis of the CMOI-/- embryos showed reduced levels of four phosphatidylcholine and three phosphatidylethanolamine acyl chain species, and of eight triacylglycerol species with four or more unsaturations and fifty-two or more carbons in the acyl chains. phosphatidylethanolamine 122-146 beta-carotene oxygenase 1 Mus musculus 46-50 25276814-2 2014 We formulated HA-phospholipid (phosphatidylethanolamine, HA-PE) polymers that form pericellular coats around cultured dermal fibroblasts independently of CD44 or RHAMM display. phosphatidylethanolamine 31-55 CD44 antigen Mus musculus 154-158 25763700-6 2014 It was shown that overexpression of PIS1 and PIS2 (involved in phosphatidylinositol biosynthesis) induces the synthesis of phosphatidylinositol (PI) but also of phosphatidic acid and that overexpression of PIS1 also induces the synthesis of phosphatidylethanolamine and diacylglycerol. phosphatidylethanolamine 241-265 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 36-40 24391008-2 2013 Among these genes, ATG8 encodes a ubiquitin-like protein that is conjugated to a phosphatidylethanolamine (PE) membrane by the ubiquitination system. phosphatidylethanolamine 107-109 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 19-23 24018423-0 2013 Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D. phosphatidylethanolamine 24-48 N-acyl phosphatidylethanolamine phospholipase D Homo sapiens 67-99 23883581-4 2013 Thrombin, collagen, or ionophore activation stimulated generation of families of PGs comprising PGE2 and D2 attached to four phosphatidylethanolamine (PE) phospholipids (16:0p/, 18:1p/, 18:0p/, and 18:0a/). phosphatidylethanolamine 125-149 coagulation factor II, thrombin Homo sapiens 0-8 23883581-4 2013 Thrombin, collagen, or ionophore activation stimulated generation of families of PGs comprising PGE2 and D2 attached to four phosphatidylethanolamine (PE) phospholipids (16:0p/, 18:1p/, 18:0p/, and 18:0a/). phosphatidylethanolamine 151-153 coagulation factor II, thrombin Homo sapiens 0-8 23883581-9 2013 This indicates that they form in platelets via rapid esterification of COX-1 derived PGE2/D2 into PE. phosphatidylethanolamine 98-100 mitochondrially encoded cytochrome c oxidase I Homo sapiens 71-76 24097981-7 2013 In contrast, ABCA4 transported phosphatidylethanolamine in the reverse direction. phosphatidylethanolamine 31-55 ATP binding cassette subfamily A member 4 Homo sapiens 13-18 23505042-7 2013 We also observed that the flux from PE to PC is stimulated in the liver of Gnmt(-/-) mice and that this results in a reduction in PE content and a marked increase in DG and TG. phosphatidylethanolamine 36-38 glycine N-methyltransferase Mus musculus 75-79 24146988-2 2013 The enzyme contributing most to PE formation is the mitochondrial phosphatidylserine decarboxylase 1 (Psd1p) which catalyzes conversion of phosphatidylserine (PS) to PE. phosphatidylethanolamine 32-34 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 102-107 24146988-2 2013 The enzyme contributing most to PE formation is the mitochondrial phosphatidylserine decarboxylase 1 (Psd1p) which catalyzes conversion of phosphatidylserine (PS) to PE. phosphatidylethanolamine 166-168 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 102-107 23505042-7 2013 We also observed that the flux from PE to PC is stimulated in the liver of Gnmt(-/-) mice and that this results in a reduction in PE content and a marked increase in DG and TG. phosphatidylethanolamine 130-132 glycine N-methyltransferase Mus musculus 75-79 23505042-9 2013 Gnmt(-/-) mice with an additional deletion of perilipin2, the predominant lipid droplet protein, maintain high SAMe levels, with a concurrent increased flux from PE to PC, but do not develop liver steatosis. phosphatidylethanolamine 162-164 glycine N-methyltransferase Mus musculus 0-4 23505042-9 2013 Gnmt(-/-) mice with an additional deletion of perilipin2, the predominant lipid droplet protein, maintain high SAMe levels, with a concurrent increased flux from PE to PC, but do not develop liver steatosis. phosphatidylethanolamine 162-164 predicted gene 12551 Mus musculus 46-56 23426360-5 2013 Herein we describe a new biochemical assay for lipin 1 using mixtures of phosphatidic acid (PA) and phosphatidylethanolamine that reflects its physiological activity and membrane interaction. phosphatidylethanolamine 100-124 lipin 1 Homo sapiens 47-54 23872271-2 2013 In Arabidopsis, pect1-4 mutants exhibit reduced cellular phosphatidylethanolamine levels owing to reduced CTP:phosphorylethanolamine cytidylyltransferase (PECT; EC 2.7.7.14) activity. phosphatidylethanolamine 57-81 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 16-21 23872271-3 2013 Consequently, pect1-4 mutants may have decreased mitochondrial phosphatidylethanolamine levels, thereby affecting respiration capacity. phosphatidylethanolamine 63-87 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 14-19 23872271-11 2013 COX activity was lower in pect1-4 mitochondria at 5 weeks, most probably due to reduced phosphatidylethanolamine levels and/or an altered phosphatidylethanolamine:phosphatidylcholine ratio. phosphatidylethanolamine 88-112 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 26-31 23872271-11 2013 COX activity was lower in pect1-4 mitochondria at 5 weeks, most probably due to reduced phosphatidylethanolamine levels and/or an altered phosphatidylethanolamine:phosphatidylcholine ratio. phosphatidylethanolamine 138-162 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 26-31 23872271-12 2013 Thus, PECT1 regulates mitochondrial phosphatidylethanolamine levels, which are important for maintaining respiration capacity in Arabidopsis leaves during prolonged growth under short-day conditions. phosphatidylethanolamine 36-60 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 6-11 23468132-5 2013 The expression of ABCB4, but not ABCB1, led to significant increases in the phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM) contents in nonraft membranes and further enrichment of SM and cholesterol in raft membranes. phosphatidylethanolamine 102-126 ATP binding cassette subfamily B member 4 Homo sapiens 18-23 23468132-5 2013 The expression of ABCB4, but not ABCB1, led to significant increases in the phosphatidylcholine (PC), phosphatidylethanolamine (PE), and sphingomyelin (SM) contents in nonraft membranes and further enrichment of SM and cholesterol in raft membranes. phosphatidylethanolamine 128-130 ATP binding cassette subfamily B member 4 Homo sapiens 18-23 23468132-6 2013 The ABCB4-mediated efflux of PC, PE, and SM was significantly stimulated by taurocholate, while the efflux of PE and SM was much less than that of PC. phosphatidylethanolamine 33-35 ATP binding cassette subfamily B member 4 Homo sapiens 4-9 23468132-6 2013 The ABCB4-mediated efflux of PC, PE, and SM was significantly stimulated by taurocholate, while the efflux of PE and SM was much less than that of PC. phosphatidylethanolamine 110-112 ATP binding cassette subfamily B member 4 Homo sapiens 4-9 23530199-4 2013 Four percent of the total cellular PE/PS pool (~300 ng/2 x 10(8) cells, thrombin), is externalized via calcium mobilization and protease-activated receptors-1 and -4, and 48% is contained in microparticles. phosphatidylethanolamine 35-37 coagulation factor II, thrombin Homo sapiens 72-80 23530199-4 2013 Four percent of the total cellular PE/PS pool (~300 ng/2 x 10(8) cells, thrombin), is externalized via calcium mobilization and protease-activated receptors-1 and -4, and 48% is contained in microparticles. phosphatidylethanolamine 35-37 coagulation factor II thrombin receptor Homo sapiens 128-165 23763831-7 2013 Mt-I rapidly hydrolyzed phosphatidylcholine and phosphatidylethanolamine but not phosphatidylserine, but no phospho-lipids were hydrolyzed in the presence of Mt-II. phosphatidylethanolamine 48-72 metallothionein 1 Mus musculus 0-4 23721406-2 2013 The phosphatidylethanolamine (PE)-conjugation of the Atg8 protein plays an important role in the yeast autophagy process. phosphatidylethanolamine 4-28 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 53-57 23721406-2 2013 The phosphatidylethanolamine (PE)-conjugation of the Atg8 protein plays an important role in the yeast autophagy process. phosphatidylethanolamine 30-32 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 53-57 22465357-8 2013 A selective increase of monounsaturated phosphatidylcholine and phosphatidylethanolamine which positively correlate with hepatic and systemic triglycerides with the latter being elevated in APN-/- mice, was identified. phosphatidylethanolamine 64-88 adiponectin, C1Q and collagen domain containing Mus musculus 190-193 23446897-1 2013 BACKGROUND: Phosphatidylcholine (PC) produced via the S-adenosylmethionine-dependent phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is enriched with docosahexaenoic acid (DHA). phosphatidylethanolamine 85-109 phosphatidylethanolamine N-methyltransferase Homo sapiens 136-140 23446897-1 2013 BACKGROUND: Phosphatidylcholine (PC) produced via the S-adenosylmethionine-dependent phosphatidylethanolamine (PE) N-methyltransferase (PEMT) pathway is enriched with docosahexaenoic acid (DHA). phosphatidylethanolamine 111-113 phosphatidylethanolamine N-methyltransferase Homo sapiens 136-140 23585650-5 2013 Lipid profiling revealed that 34C species of phosphatidylglycerol (PG) and monogalactosyl diacylglycerol (MGDG) content in ads2 mutants were lower and phosphatidic acid, phosphatidylinositol, phosphatidylethanolamine, phosphatidylcholine, lyso-phosphatidylcholine, and phosphatidylserine were higher than the wild type. phosphatidylethanolamine 192-216 16:0delta9 desaturase 2 Arabidopsis thaliana 123-127 23369752-0 2013 GLTP-fold interaction with planar phosphatidylcholine surfaces is synergistically stimulated by phosphatidic acid and phosphatidylethanolamine. phosphatidylethanolamine 118-142 glycolipid transfer protein Homo sapiens 0-4 23503366-1 2013 Two autophagy-related ubiquitin-like systems have unique features: the E2 enzyme Atg3 conjugates the ubiquitin-like protein Atg8 to the lipid phosphatidylethanolamine, and the other ubiquitin-like protein conjugate Atg12-Atg5 promotes that conjugase activity of Atg3. phosphatidylethanolamine 142-166 Atg3p Saccharomyces cerevisiae S288C 81-85 23503366-1 2013 Two autophagy-related ubiquitin-like systems have unique features: the E2 enzyme Atg3 conjugates the ubiquitin-like protein Atg8 to the lipid phosphatidylethanolamine, and the other ubiquitin-like protein conjugate Atg12-Atg5 promotes that conjugase activity of Atg3. phosphatidylethanolamine 142-166 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 124-128 23372157-7 2013 Our results indicated that phosphatidylethanolamine (PE) among the lipids tested and apoptotic cells were possible ligands for both CD300C and CD300A. phosphatidylethanolamine 27-51 CD300c molecule Homo sapiens 132-138 23372157-7 2013 Our results indicated that phosphatidylethanolamine (PE) among the lipids tested and apoptotic cells were possible ligands for both CD300C and CD300A. phosphatidylethanolamine 27-51 CD300a molecule Homo sapiens 143-149 23372157-7 2013 Our results indicated that phosphatidylethanolamine (PE) among the lipids tested and apoptotic cells were possible ligands for both CD300C and CD300A. phosphatidylethanolamine 53-55 CD300c molecule Homo sapiens 132-138 23372157-7 2013 Our results indicated that phosphatidylethanolamine (PE) among the lipids tested and apoptotic cells were possible ligands for both CD300C and CD300A. phosphatidylethanolamine 53-55 CD300a molecule Homo sapiens 143-149 22877991-1 2013 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to phosphatidylcholine (PC). phosphatidylethanolamine 81-105 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 23537027-2 2013 Animal studies suggest that the hepatic ratio of phosphatidylcholine (PC) to phosphatidylethanolamine (PE) contributes to steatogenesis and inflammation. phosphatidylethanolamine 77-101 procollagen C-endopeptidase enhancer Homo sapiens 70-72 23537027-2 2013 Animal studies suggest that the hepatic ratio of phosphatidylcholine (PC) to phosphatidylethanolamine (PE) contributes to steatogenesis and inflammation. phosphatidylethanolamine 77-101 procollagen C-endopeptidase enhancer Homo sapiens 103-105 22877991-1 2013 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to phosphatidylcholine (PC). phosphatidylethanolamine 81-105 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 22877991-3 2013 The supply of the substrates AdoMet and phosphatidylethanolamine, and the product AdoHcy, can regulate the activity of PEMT. phosphatidylethanolamine 40-64 phosphatidylethanolamine N-methyltransferase Mus musculus 119-123 23193974-7 2013 Furthermore, the phospholipid composition markedly influences P450 turnover and b(5) stimulation and specificity, particularly for CYP17A1, in the following order: phosphatidylserine > phosphatidylethanolamine > phosphatidylcholine. phosphatidylethanolamine 188-212 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 131-138 22960354-8 2013 PE is synthesized in mammalian cells by four different pathways, the quantitatively most important of which are the CDP-ethanolamine pathway that produces PE in the ER, and PS decarboxylation that occurs in mitochondria. phosphatidylethanolamine 0-2 cut like homeobox 1 Homo sapiens 116-119 22960354-8 2013 PE is synthesized in mammalian cells by four different pathways, the quantitatively most important of which are the CDP-ethanolamine pathway that produces PE in the ER, and PS decarboxylation that occurs in mitochondria. phosphatidylethanolamine 155-157 cut like homeobox 1 Homo sapiens 116-119 23044079-8 2013 In addition, the phosphatidylcholine/phosphatidylethanolamine liver ratio decrease was less important in TNF(-/-) mice. phosphatidylethanolamine 37-61 tumor necrosis factor Mus musculus 105-108 23354482-0 2013 Regulation of Phosphatidylethanolamine Homeostasis&#8212;The Critical Role of CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2). phosphatidylethanolamine 14-38 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 83-127 23354482-0 2013 Regulation of Phosphatidylethanolamine Homeostasis&#8212;The Critical Role of CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2). phosphatidylethanolamine 14-38 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 129-134 23354482-3 2013 CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) is the main regulatory enzyme in de novo biosynthesis of PE from ethanolamine and diacylglycerol by the CDP-ethanolamine Kennedy pathway. phosphatidylethanolamine 110-112 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 0-44 23354482-3 2013 CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) is the main regulatory enzyme in de novo biosynthesis of PE from ethanolamine and diacylglycerol by the CDP-ethanolamine Kennedy pathway. phosphatidylethanolamine 110-112 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 46-51 23354482-3 2013 CTP:phosphoethanolamine cytidylyltransferase (Pcyt2) is the main regulatory enzyme in de novo biosynthesis of PE from ethanolamine and diacylglycerol by the CDP-ethanolamine Kennedy pathway. phosphatidylethanolamine 110-112 cut-like homeobox 1 Mus musculus 157-160 23022334-2 2012 Using cells from normal kidney epithelial cell lines, we found that the antiproliferative effects of mTOR inhibitor everolimus accompanied the accumulation of a marker for cellular autophagic activity, the phosphatidylethanolamine-conjugated form of microtubule-associated protein 1 light chain 3 (LC3-II) in cells. phosphatidylethanolamine 206-230 mechanistic target of rapamycin kinase Rattus norvegicus 101-105 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. phosphatidylethanolamine 92-116 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. phosphatidylethanolamine 92-116 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. phosphatidylethanolamine 118-120 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-15 23681537-1 2013 Phospholipase D (PLD) hydrolyzes structural phospholipids like phosphatidylcholine (PC) and phosphatidylethanolamine (PE) into phosphatidic acid (PA) and free choline/ethanolamine. phosphatidylethanolamine 118-120 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 17-20 23175755-5 2013 Through forward and reverse genetics it was shown that AtADS2 is involved in the synthesis of the 24:1(n-9) and 26:1(n-9) components (X:Y, where X is chain length and Y is number of double bonds) of seed lipids, sphingolipids, and the membrane phospholipids phosphatidylserine, and phosphatidylethanolamine. phosphatidylethanolamine 282-306 16:0delta9 desaturase 2 Arabidopsis thaliana 55-61 23124206-5 2012 Two mitochondrial proteins located in the intermembrane space, Ups1p and Ups2p, have been shown to regulate PE metabolism by controlling the export of PE. phosphatidylethanolamine 108-110 Ups1p Saccharomyces cerevisiae S288C 63-68 23124206-5 2012 Two mitochondrial proteins located in the intermembrane space, Ups1p and Ups2p, have been shown to regulate PE metabolism by controlling the export of PE. phosphatidylethanolamine 108-110 Ups2p Saccharomyces cerevisiae S288C 73-78 23124206-5 2012 Two mitochondrial proteins located in the intermembrane space, Ups1p and Ups2p, have been shown to regulate PE metabolism by controlling the export of PE. phosphatidylethanolamine 151-153 Ups1p Saccharomyces cerevisiae S288C 63-68 23124206-5 2012 Two mitochondrial proteins located in the intermembrane space, Ups1p and Ups2p, have been shown to regulate PE metabolism by controlling the export of PE. phosphatidylethanolamine 151-153 Ups2p Saccharomyces cerevisiae S288C 73-78 23124206-7 2012 Here, using fluorescent PS as a substrate in an in vitro assay for Psd1p-dependent PE production in isolated mitochondria, we show that PS is transferred from the mitochondrial outer membrane to the inner membrane independently of Psd1p, Ups1p, and Ups2p and decarboxylated to PE by Psd1p in the inner membrane. phosphatidylethanolamine 83-85 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 67-72 23124206-7 2012 Here, using fluorescent PS as a substrate in an in vitro assay for Psd1p-dependent PE production in isolated mitochondria, we show that PS is transferred from the mitochondrial outer membrane to the inner membrane independently of Psd1p, Ups1p, and Ups2p and decarboxylated to PE by Psd1p in the inner membrane. phosphatidylethanolamine 277-279 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 67-72 23743710-0 2013 Phosphatidylethanolamine from phosphatidylserine decarboxylase2 is essential for autophagy under cadmium stress in Saccharomyces cerevisiae. phosphatidylethanolamine 0-24 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 30-63 23743710-3 2013 In yeast, there are four different pathways contributing to the biosynthesis of PE, and contribution to PE pool through phosphatidylserine decarboxylase2 (psd2) is not significant in normal conditions. phosphatidylethanolamine 104-106 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 120-153 23743710-3 2013 In yeast, there are four different pathways contributing to the biosynthesis of PE, and contribution to PE pool through phosphatidylserine decarboxylase2 (psd2) is not significant in normal conditions. phosphatidylethanolamine 104-106 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 155-159 23743710-6 2013 The supplementation of ethanolamine did not overcome the Cd stress and also the autophagy process, whereas overexpression of PSD2 in psd2Delta increased the cellular tolerance, PE levels, and the autophagy process against Cd stress. phosphatidylethanolamine 177-179 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 125-129 24070470-6 2013 Atg8 is then activated by Atg7 (shared with Atg12) and, via the E2 enzyme Atg3, finally conjugated to the amino group of the lipid PE (phosphatidylethanolamine). phosphatidylethanolamine 131-133 GABA type A receptor associated protein like 1 Homo sapiens 0-4 24070470-6 2013 Atg8 is then activated by Atg7 (shared with Atg12) and, via the E2 enzyme Atg3, finally conjugated to the amino group of the lipid PE (phosphatidylethanolamine). phosphatidylethanolamine 131-133 autophagy related 3 Homo sapiens 74-78 24070470-6 2013 Atg8 is then activated by Atg7 (shared with Atg12) and, via the E2 enzyme Atg3, finally conjugated to the amino group of the lipid PE (phosphatidylethanolamine). phosphatidylethanolamine 135-159 GABA type A receptor associated protein like 1 Homo sapiens 0-4 24070470-6 2013 Atg8 is then activated by Atg7 (shared with Atg12) and, via the E2 enzyme Atg3, finally conjugated to the amino group of the lipid PE (phosphatidylethanolamine). phosphatidylethanolamine 135-159 autophagy related 3 Homo sapiens 74-78 23124206-9 2012 Restoration of Psd1p levels rescued PE production defects in ups1Delta mitochondria. phosphatidylethanolamine 36-38 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 15-20 23045528-2 2012 RESULTS: Decreasing phosphatidylethanolamine reduces the rate of lipid mixing and the biogenesis of Mgm1, a mitochondrial fusion protein. phosphatidylethanolamine 20-44 dynamin-related GTPase MGM1 Saccharomyces cerevisiae S288C 100-104 23140329-1 2012 Prior studies have shown that the biological mixture of the two hydrophobic surfactant proteins, SP-B and SP-C, produces faster adsorption of the surfactant lipids to an air/water interface, and that they induce 1-palmitoyl-2-oleoyl phosphatidylethanolamine (POPE) to form inverse bicontinuous cubic phases. phosphatidylethanolamine 259-263 surfactant protein B Homo sapiens 97-101 23140329-1 2012 Prior studies have shown that the biological mixture of the two hydrophobic surfactant proteins, SP-B and SP-C, produces faster adsorption of the surfactant lipids to an air/water interface, and that they induce 1-palmitoyl-2-oleoyl phosphatidylethanolamine (POPE) to form inverse bicontinuous cubic phases. phosphatidylethanolamine 259-263 surfactant protein C Homo sapiens 106-110 22249245-3 2012 Although a form of LC3B modified by phosphatidylethanolamine (form-II) is localized in autophagosomes, it is not clear whether other LC3 proteins also function in autophagy. phosphatidylethanolamine 36-60 microtubule associated protein 1 light chain 3 beta Homo sapiens 19-23 23064152-6 2012 In a fully reconstituted system using giant unilamellar vesicles and recombinant proteins, we reveal that all components of the complex are required for efficient promotion of Atg8 conjugation to phosphatidylethanolamine and are able to assign precise functions to all of its components during this process. phosphatidylethanolamine 196-220 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 176-180 22970795-5 2012 By combining measurements of membrane binding, membrane permeabilization, and fiber formation, we show that lipids with the phosphatidylethanolamine (PE) headgroup strongly modulate the membrane disruption induced by IAPP (islet amyloid polypeptide protein), an amyloidogenic protein involved in type II diabetes. phosphatidylethanolamine 124-148 islet amyloid polypeptide Homo sapiens 217-221 22984266-2 2012 In the yeast Saccharomyces cerevisiae, the majority of cellular phosphatidylethanolamine is synthesized by the mitochondrial phosphatidylserine decarboxylase 1 (Psd1). phosphatidylethanolamine 64-88 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 125-159 22984266-2 2012 In the yeast Saccharomyces cerevisiae, the majority of cellular phosphatidylethanolamine is synthesized by the mitochondrial phosphatidylserine decarboxylase 1 (Psd1). phosphatidylethanolamine 64-88 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 161-165 23039070-7 2012 Insulin was the main hormone inducing compositional differences in membrane lipids, increasing phosphatidylethanolamine and phosphatidylinositol and decreasing sphingomyelin and cholesterol. phosphatidylethanolamine 95-119 insulin Homo sapiens 0-7 22970795-5 2012 By combining measurements of membrane binding, membrane permeabilization, and fiber formation, we show that lipids with the phosphatidylethanolamine (PE) headgroup strongly modulate the membrane disruption induced by IAPP (islet amyloid polypeptide protein), an amyloidogenic protein involved in type II diabetes. phosphatidylethanolamine 124-148 islet amyloid polypeptide Homo sapiens 223-256 22249245-3 2012 Although a form of LC3B modified by phosphatidylethanolamine (form-II) is localized in autophagosomes, it is not clear whether other LC3 proteins also function in autophagy. phosphatidylethanolamine 36-60 microtubule associated protein 1 light chain 3 alpha Homo sapiens 19-22 22970795-5 2012 By combining measurements of membrane binding, membrane permeabilization, and fiber formation, we show that lipids with the phosphatidylethanolamine (PE) headgroup strongly modulate the membrane disruption induced by IAPP (islet amyloid polypeptide protein), an amyloidogenic protein involved in type II diabetes. phosphatidylethanolamine 150-152 islet amyloid polypeptide Homo sapiens 217-221 22970795-5 2012 By combining measurements of membrane binding, membrane permeabilization, and fiber formation, we show that lipids with the phosphatidylethanolamine (PE) headgroup strongly modulate the membrane disruption induced by IAPP (islet amyloid polypeptide protein), an amyloidogenic protein involved in type II diabetes. phosphatidylethanolamine 150-152 islet amyloid polypeptide Homo sapiens 223-256 23075684-1 2012 BACKGROUND: Raf kinase inhibitory protein (RKIP) belongs to the phosphatidylethanolamine binding protein family. phosphatidylethanolamine 64-88 phosphatidylethanolamine binding protein 1 Homo sapiens 12-41 23075684-1 2012 BACKGROUND: Raf kinase inhibitory protein (RKIP) belongs to the phosphatidylethanolamine binding protein family. phosphatidylethanolamine 64-88 phosphatidylethanolamine binding protein 1 Homo sapiens 43-47 22344035-4 2012 A loss of flippase activity, or pharmacological blockage of the inward flipping of phosphatidylethanolamine, a phospholipid with a neutral head group, disrupts Cdc42 polarity maintained by guanine nucleotide dissociation inhibitor-mediated recycling. phosphatidylethanolamine 83-107 Rho family GTPase CDC42 Saccharomyces cerevisiae S288C 160-165 22711839-5 2012 Moreover, propagation with only one functional cofactor (phosphatidylethanolamine) induced the conversion of three distinct strains into a single strain with unique infectious properties and PrP(Sc) structure. phosphatidylethanolamine 57-81 prion protein Homo sapiens 191-194 22647268-2 2012 The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) by PE-N-methyltransferase (PEMT) in the liver. phosphatidylethanolamine 71-95 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 132-154 22647268-2 2012 The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) by PE-N-methyltransferase (PEMT) in the liver. phosphatidylethanolamine 71-95 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 156-160 22647268-2 2012 The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) by PE-N-methyltransferase (PEMT) in the liver. phosphatidylethanolamine 97-99 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 132-154 22647268-2 2012 The availability of these vitamins may therefore modify methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) by PE-N-methyltransferase (PEMT) in the liver. phosphatidylethanolamine 97-99 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 156-160 22403410-9 2012 Finally, pulse-chase experiments using [(14)C]serine revealed that Ups1p and Ups2p antagonistically regulate conversion of phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 123-147 Ups1p Saccharomyces cerevisiae S288C 67-72 22403410-9 2012 Finally, pulse-chase experiments using [(14)C]serine revealed that Ups1p and Ups2p antagonistically regulate conversion of phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 123-147 Ups2p Saccharomyces cerevisiae S288C 77-82 22622160-3 2012 Approximately one-fourth of all of the characterized Atg proteins that participate in autophagosome biogenesis affect Atg8, regulating its conjugation to phosphatidylethanolamine (PE), localization to the phagophore assembly site and/or subsequent deconjugation. phosphatidylethanolamine 154-178 GABA type A receptor associated protein like 1 Homo sapiens 118-122 22622160-3 2012 Approximately one-fourth of all of the characterized Atg proteins that participate in autophagosome biogenesis affect Atg8, regulating its conjugation to phosphatidylethanolamine (PE), localization to the phagophore assembly site and/or subsequent deconjugation. phosphatidylethanolamine 180-182 GABA type A receptor associated protein like 1 Homo sapiens 118-122 22764088-1 2012 Phosphatidylethanolamine is an important inner-leaflet phospholipid, and CTP:phosphoethanolamine cytidylyltransferase-Pcyt2 acts as the main regulator of the de novo phosphatidylethanolamine synthesis from ethanolamine and diacylglycerol. phosphatidylethanolamine 166-190 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 73-117 22764088-1 2012 Phosphatidylethanolamine is an important inner-leaflet phospholipid, and CTP:phosphoethanolamine cytidylyltransferase-Pcyt2 acts as the main regulator of the de novo phosphatidylethanolamine synthesis from ethanolamine and diacylglycerol. phosphatidylethanolamine 166-190 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 118-123 22735453-0 2012 ABCA4 is an N-retinylidene-phosphatidylethanolamine and phosphatidylethanolamine importer. phosphatidylethanolamine 27-51 ATP binding cassette subfamily A member 4 Homo sapiens 0-5 22735453-4 2012 Here we show that ABCA4, an ABC transporter found in retinal photoreceptor cells and associated with Stargardt macular degeneration, is a novel importer that actively flips N-retinylidene-phosphatidylethanolamine from the lumen to the cytoplasmic leaflet of disc membranes, thereby facilitating the removal of potentially toxic retinoid compounds from photoreceptors. phosphatidylethanolamine 188-212 ATP binding cassette subfamily A member 4 Homo sapiens 18-23 22735453-4 2012 Here we show that ABCA4, an ABC transporter found in retinal photoreceptor cells and associated with Stargardt macular degeneration, is a novel importer that actively flips N-retinylidene-phosphatidylethanolamine from the lumen to the cytoplasmic leaflet of disc membranes, thereby facilitating the removal of potentially toxic retinoid compounds from photoreceptors. phosphatidylethanolamine 188-212 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 28-43 22735453-5 2012 ABCA4 also actively transports phosphatidylethanolamine in the same direction. phosphatidylethanolamine 31-55 ATP binding cassette subfamily A member 4 Homo sapiens 0-5 22652539-3 2012 Atg8 is a unique Ubl protein whose conjugation target is the lipid phosphatidylethanolamine (PE). phosphatidylethanolamine 67-91 GABA type A receptor associated protein like 1 Homo sapiens 0-4 22652539-3 2012 Atg8 is a unique Ubl protein whose conjugation target is the lipid phosphatidylethanolamine (PE). phosphatidylethanolamine 93-95 GABA type A receptor associated protein like 1 Homo sapiens 0-4 22339418-3 2012 The biosynthesis of PE from DAG and ethanolamine was regulated at the level of formation of CDP-ethanolamine, the metabolic step catalyzed by Pcyt2. phosphatidylethanolamine 20-22 cut like homeobox 1 Homo sapiens 92-95 22339418-3 2012 The biosynthesis of PE from DAG and ethanolamine was regulated at the level of formation of CDP-ethanolamine, the metabolic step catalyzed by Pcyt2. phosphatidylethanolamine 20-22 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 142-147 22339418-10 2012 The results established that elevated DAG formation and the increased activity of the rate-regulatory enzyme Pcyt2 were critical modulators of the PE Kennedy pathway, and total PE content in serum deprived breast cancer cells. phosphatidylethanolamine 147-149 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 109-114 22121002-6 2012 Furthermore, a decrease in HCV RNA replication was observed by blocking the LDLR with a specific antibody, and this was associated with an increase in the ratio of phosphatidylethanolamine to phosphatidylcholine in host cells. phosphatidylethanolamine 164-188 low density lipoprotein receptor Homo sapiens 76-80 22302738-0 2012 Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells. phosphatidylethanolamine 22-46 CD300a molecule Homo sapiens 6-12 22302738-5 2012 Using surface plasmon resonance, ultracentrifugation, ELISA, and reporter cell assays, we identified phosphatidylethanolamine (PE) and phosphatidylserine (PS), 2 phospholipids that translocate to the outer leaflet of the plasma membrane of dead cells, as the ligands for CD300a. phosphatidylethanolamine 101-125 CD300a molecule Homo sapiens 271-277 22302738-6 2012 Mutational and structural modeling studies identified residues that are involved in the binding of CD300a to PE and PS and that form a cavity where the hydrophilic heads of PE and PS, can penetrate. phosphatidylethanolamine 109-111 CD300a molecule Homo sapiens 99-105 22302738-8 2012 Collectively, our results indicate that PE and PS are ligands for CD300a, and that this interaction plays an important role in regulating the removal of dead cells. phosphatidylethanolamine 40-42 CD300a molecule Homo sapiens 66-72 22302004-1 2012 Atg4 is required for cleaving Atg8, allowing it to be conjugated to phosphatidylethanolamine on phagophore membranes, a key step in autophagosome biogenesis. phosphatidylethanolamine 68-92 GABA type A receptor associated protein like 2 Homo sapiens 30-34 22107873-4 2012 Deletion of BTN1 (btn1-Delta) led to a decreased level of phosphatidylethanolamine (PtdEtn) in both mitochondrial and vacuolar membranes. phosphatidylethanolamine 84-90 CLN3 lysosomal/endosomal transmembrane protein, battenin Homo sapiens 12-16 22107873-4 2012 Deletion of BTN1 (btn1-Delta) led to a decreased level of phosphatidylethanolamine (PtdEtn) in both mitochondrial and vacuolar membranes. phosphatidylethanolamine 84-90 CLN3 lysosomal/endosomal transmembrane protein, battenin Homo sapiens 18-22 22107873-5 2012 In yeast there are two phosphatidylserine (PtdSer) decarboxylases, Psd1p and Psd2p, and these proteins are responsible for the synthesis of PtdEtn in mitochondria and Golgi-endosome, respectively. phosphatidylethanolamine 140-146 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 67-72 22107873-5 2012 In yeast there are two phosphatidylserine (PtdSer) decarboxylases, Psd1p and Psd2p, and these proteins are responsible for the synthesis of PtdEtn in mitochondria and Golgi-endosome, respectively. phosphatidylethanolamine 140-146 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 77-82 22107873-6 2012 Deletion of both BTN1 and PSD1 (btn1-Delta psd1-Delta) led to a further decrease in levels of PtdEtn in ER membranes associated to mitochondria (MAMs), with a parallel increase in PtdSer. phosphatidylethanolamine 94-100 amino acid transporter YHC3 Saccharomyces cerevisiae S288C 17-21 22107873-6 2012 Deletion of both BTN1 and PSD1 (btn1-Delta psd1-Delta) led to a further decrease in levels of PtdEtn in ER membranes associated to mitochondria (MAMs), with a parallel increase in PtdSer. phosphatidylethanolamine 94-100 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 26-30 22107873-6 2012 Deletion of both BTN1 and PSD1 (btn1-Delta psd1-Delta) led to a further decrease in levels of PtdEtn in ER membranes associated to mitochondria (MAMs), with a parallel increase in PtdSer. phosphatidylethanolamine 94-100 amino acid transporter YHC3 Saccharomyces cerevisiae S288C 32-36 22107873-6 2012 Deletion of both BTN1 and PSD1 (btn1-Delta psd1-Delta) led to a further decrease in levels of PtdEtn in ER membranes associated to mitochondria (MAMs), with a parallel increase in PtdSer. phosphatidylethanolamine 94-100 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 43-47 22107873-8 2012 Moreover, btn1-Delta affects the synthesis of PtdEtn by the Kennedy pathway and impairs the ability of psd1-Delta cells to restore PtdEtn to normal levels in mitochondria and vacuoles by ethanolamine addition. phosphatidylethanolamine 46-52 amino acid transporter YHC3 Saccharomyces cerevisiae S288C 10-14 22107873-8 2012 Moreover, btn1-Delta affects the synthesis of PtdEtn by the Kennedy pathway and impairs the ability of psd1-Delta cells to restore PtdEtn to normal levels in mitochondria and vacuoles by ethanolamine addition. phosphatidylethanolamine 131-137 amino acid transporter YHC3 Saccharomyces cerevisiae S288C 10-14 22107873-8 2012 Moreover, btn1-Delta affects the synthesis of PtdEtn by the Kennedy pathway and impairs the ability of psd1-Delta cells to restore PtdEtn to normal levels in mitochondria and vacuoles by ethanolamine addition. phosphatidylethanolamine 131-137 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 103-107 22344035-5 2012 Phosphatidylethanolamine flipping may reduce the charge interaction between a Cdc42 carboxy-terminal cationic region with the plasma membrane inner leaflet, enriched for the negatively charged lipid phosphatidylserine. phosphatidylethanolamine 0-24 Rho family GTPase CDC42 Saccharomyces cerevisiae S288C 78-83 22344035-6 2012 Using a reconstituted system with supported lipid bilayers, we show that the relative composition of phosphatidylethanolamine versus phosphatidylserine directly modulates Cdc42 extraction from the membrane by guanine nucleotide dissociation inhibitor. phosphatidylethanolamine 101-125 Rho family GTPase CDC42 Saccharomyces cerevisiae S288C 171-176 22177957-4 2012 The mutants deleted for VPS51, VPS52, VPS53, and VPS54 were impaired in the uptake of fluorescently labeled PE. phosphatidylethanolamine 108-110 Vps51p Saccharomyces cerevisiae S288C 24-29 22240591-2 2012 A ubiquitin-like system mediates the conjugation of the C terminus of Atg8 to the lipid phosphatidylethanolamine (PE), and this conjugate (Atg8-PE) plays a crucial role in autophagosome formation at the phagophore assembly site/pre-autophagosomal structure (PAS). phosphatidylethanolamine 88-112 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 70-74 22240591-2 2012 A ubiquitin-like system mediates the conjugation of the C terminus of Atg8 to the lipid phosphatidylethanolamine (PE), and this conjugate (Atg8-PE) plays a crucial role in autophagosome formation at the phagophore assembly site/pre-autophagosomal structure (PAS). phosphatidylethanolamine 88-112 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 139-143 22240591-2 2012 A ubiquitin-like system mediates the conjugation of the C terminus of Atg8 to the lipid phosphatidylethanolamine (PE), and this conjugate (Atg8-PE) plays a crucial role in autophagosome formation at the phagophore assembly site/pre-autophagosomal structure (PAS). phosphatidylethanolamine 114-116 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 70-74 22240591-2 2012 A ubiquitin-like system mediates the conjugation of the C terminus of Atg8 to the lipid phosphatidylethanolamine (PE), and this conjugate (Atg8-PE) plays a crucial role in autophagosome formation at the phagophore assembly site/pre-autophagosomal structure (PAS). phosphatidylethanolamine 114-116 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 139-143 22107873-4 2012 Deletion of BTN1 (btn1-Delta) led to a decreased level of phosphatidylethanolamine (PtdEtn) in both mitochondrial and vacuolar membranes. phosphatidylethanolamine 58-82 CLN3 lysosomal/endosomal transmembrane protein, battenin Homo sapiens 12-16 22107873-4 2012 Deletion of BTN1 (btn1-Delta) led to a decreased level of phosphatidylethanolamine (PtdEtn) in both mitochondrial and vacuolar membranes. phosphatidylethanolamine 58-82 CLN3 lysosomal/endosomal transmembrane protein, battenin Homo sapiens 18-22 22177957-4 2012 The mutants deleted for VPS51, VPS52, VPS53, and VPS54 were impaired in the uptake of fluorescently labeled PE. phosphatidylethanolamine 108-110 Vps52p Saccharomyces cerevisiae S288C 31-36 22177957-4 2012 The mutants deleted for VPS51, VPS52, VPS53, and VPS54 were impaired in the uptake of fluorescently labeled PE. phosphatidylethanolamine 108-110 Vps53p Saccharomyces cerevisiae S288C 38-43 22177957-4 2012 The mutants deleted for VPS51, VPS52, VPS53, and VPS54 were impaired in the uptake of fluorescently labeled PE. phosphatidylethanolamine 108-110 Vps54p Saccharomyces cerevisiae S288C 49-54 21640203-4 2012 This processing step is essential for conjugation of Atg8 with phosphatidylethanolamine and, subsequently, autophagosome formation. phosphatidylethanolamine 63-87 GABA type A receptor associated protein like 1 Homo sapiens 53-57 22023223-0 2012 Alterations in phosphatidylethanolamine levels affect the generation of Abeta. phosphatidylethanolamine 15-39 amyloid beta precursor protein Homo sapiens 72-77 21968070-3 2012 The accumulation of PUFAs in phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine correlated with an induced lysophosphatidic acid acyltransferase (LPAAT)3 mRNA expression, increased microsomal LPAAT3 activity, and shift of LPAAT specificity to PUFA-coenzyme A. phosphatidylethanolamine 50-74 1-acylglycerol-3-phosphate O-acyltransferase 3 Mus musculus 165-172 21859710-0 2011 Modulation of prothrombinase assembly and activity by phosphatidylethanolamine. phosphatidylethanolamine 54-78 coagulation factor X Homo sapiens 14-28 22426725-1 2012 We compared here the purification procedures, the pH, the calcium, the bile salts, and the temperature dependencies as well as the catalytic activities on phosphatidylcholine (PC) and phosphatidylethanolamine (PE) of two purified secreted PLA2 from chicken pancreatic (ChPLA2-IB) and chicken intestinal (ChPLA2-IIA) origins. phosphatidylethanolamine 184-208 phospholipase A2 group IIA Gallus gallus 239-243 22426725-1 2012 We compared here the purification procedures, the pH, the calcium, the bile salts, and the temperature dependencies as well as the catalytic activities on phosphatidylcholine (PC) and phosphatidylethanolamine (PE) of two purified secreted PLA2 from chicken pancreatic (ChPLA2-IB) and chicken intestinal (ChPLA2-IIA) origins. phosphatidylethanolamine 210-212 phospholipase A2 group IIA Gallus gallus 239-243 22745828-4 2012 De novo synthesis of phosphatidylcholine and cholesterolesters was increased whereas phosphatidylethanolamine and triacylglycerol formation was reduced in SCD5-expressing cells with respect to their controls, suggesting a differential use of SCD5 products for lipogenic reactions. phosphatidylethanolamine 85-109 stearoyl-CoA desaturase 5 Homo sapiens 155-159 22097922-9 2011 The lipids phosphatidylethanolamine and phosphatidylglycerol were identified to play a role in the interaction of the hydrogenase module with the cytochrome b subunit. phosphatidylethanolamine 11-35 H16_RS16945 Ralstonia eutropha H16 146-158 22100064-5 2011 TAT-5 localizes to the plasma membrane and its loss results in phosphatidylethanolamine exposure on cell surfaces. phosphatidylethanolamine 63-87 Phospholipid-transporting ATPase;putative phospholipid-transporting ATPase tat-5 Caenorhabditis elegans 0-5 22100064-8 2011 TAT-5 provides a potential molecular link between loss of phosphatidylethanolamine asymmetry and the dynamic budding of vesicles from the plasma membrane, supporting the hypothesis that lipid asymmetry regulates budding. phosphatidylethanolamine 58-82 Phospholipid-transporting ATPase;putative phospholipid-transporting ATPase tat-5 Caenorhabditis elegans 0-5 22024756-2 2011 For example, Atg8 is involved in cargo recognition, and the amount of Atg8 in part determines the size of the autophagosome,4 whereas Atg12 is part of a trimer that may function as an E3 ligase to facilitate Atg8 conjugation to phosphatidylethanolamine and determine, in part, the site of the conjugation reaction. phosphatidylethanolamine 228-252 autophagy related 12 Homo sapiens 134-139 21875690-1 2011 In the yeast Saccharomyces cerevisiae triacylglycerols (TAG) are synthesized by the acyl-CoA dependent acyltransferases Dga1p, Are1p, Are2p and the acyl-CoA independent phospholipid:diacylglycerol acyltransferase (PDAT) Lro1p which uses phosphatidylethanolamine (PE) as a preferred acyl donor. phosphatidylethanolamine 237-261 diacylglycerol O-acyltransferase Saccharomyces cerevisiae S288C 120-125 21875690-1 2011 In the yeast Saccharomyces cerevisiae triacylglycerols (TAG) are synthesized by the acyl-CoA dependent acyltransferases Dga1p, Are1p, Are2p and the acyl-CoA independent phospholipid:diacylglycerol acyltransferase (PDAT) Lro1p which uses phosphatidylethanolamine (PE) as a preferred acyl donor. phosphatidylethanolamine 237-261 sterol acyltransferase Saccharomyces cerevisiae S288C 127-132 21875690-1 2011 In the yeast Saccharomyces cerevisiae triacylglycerols (TAG) are synthesized by the acyl-CoA dependent acyltransferases Dga1p, Are1p, Are2p and the acyl-CoA independent phospholipid:diacylglycerol acyltransferase (PDAT) Lro1p which uses phosphatidylethanolamine (PE) as a preferred acyl donor. phosphatidylethanolamine 237-261 sterol acyltransferase Saccharomyces cerevisiae S288C 134-139 21875690-1 2011 In the yeast Saccharomyces cerevisiae triacylglycerols (TAG) are synthesized by the acyl-CoA dependent acyltransferases Dga1p, Are1p, Are2p and the acyl-CoA independent phospholipid:diacylglycerol acyltransferase (PDAT) Lro1p which uses phosphatidylethanolamine (PE) as a preferred acyl donor. phosphatidylethanolamine 263-265 diacylglycerol O-acyltransferase Saccharomyces cerevisiae S288C 120-125 21875690-1 2011 In the yeast Saccharomyces cerevisiae triacylglycerols (TAG) are synthesized by the acyl-CoA dependent acyltransferases Dga1p, Are1p, Are2p and the acyl-CoA independent phospholipid:diacylglycerol acyltransferase (PDAT) Lro1p which uses phosphatidylethanolamine (PE) as a preferred acyl donor. phosphatidylethanolamine 263-265 sterol acyltransferase Saccharomyces cerevisiae S288C 127-132 21875690-1 2011 In the yeast Saccharomyces cerevisiae triacylglycerols (TAG) are synthesized by the acyl-CoA dependent acyltransferases Dga1p, Are1p, Are2p and the acyl-CoA independent phospholipid:diacylglycerol acyltransferase (PDAT) Lro1p which uses phosphatidylethanolamine (PE) as a preferred acyl donor. phosphatidylethanolamine 263-265 sterol acyltransferase Saccharomyces cerevisiae S288C 134-139 21875690-8 2011 Our findings imply that (i) TAG and PE syntheses in the yeast are tightly linked; and (ii) TAG formation by the PDAT Lro1p strongly depends on PE synthesis through the CDP-Etn pathway. phosphatidylethanolamine 36-38 phospholipid:diacylglycerol acyltransferase Saccharomyces cerevisiae S288C 117-122 21875690-8 2011 Our findings imply that (i) TAG and PE syntheses in the yeast are tightly linked; and (ii) TAG formation by the PDAT Lro1p strongly depends on PE synthesis through the CDP-Etn pathway. phosphatidylethanolamine 143-145 phospholipid:diacylglycerol acyltransferase Saccharomyces cerevisiae S288C 117-122 21958070-3 2011 Phosphatidylethanolamine (PE) is converted to phosphatidylcholine (PC) in the liver by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 0-24 phosphatidylethanolamine N-methyltransferase Sus scrofa 87-131 21958070-3 2011 Phosphatidylethanolamine (PE) is converted to phosphatidylcholine (PC) in the liver by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 0-24 phosphatidylethanolamine N-methyltransferase Sus scrofa 133-137 21958070-3 2011 Phosphatidylethanolamine (PE) is converted to phosphatidylcholine (PC) in the liver by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 26-28 phosphatidylethanolamine N-methyltransferase Sus scrofa 87-131 21958070-3 2011 Phosphatidylethanolamine (PE) is converted to phosphatidylcholine (PC) in the liver by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 26-28 phosphatidylethanolamine N-methyltransferase Sus scrofa 133-137 21930701-5 2011 Our study reveals that the MSF1 domain of Ups2p maintains proper mitochondrial electron transport chain function, respiratory competency, and mitochondrial phosphatidylethanolamine metabolism. phosphatidylethanolamine 156-180 septin 9 Homo sapiens 27-31 21930701-5 2011 Our study reveals that the MSF1 domain of Ups2p maintains proper mitochondrial electron transport chain function, respiratory competency, and mitochondrial phosphatidylethanolamine metabolism. phosphatidylethanolamine 156-180 Ups2p Saccharomyces cerevisiae S288C 42-47 21930701-8 2011 The regulation of phosphatidylethanolamine levels by the MSF1 domain is antagonized by the Ups2p LEA-like domain. phosphatidylethanolamine 18-42 septin 9 Homo sapiens 57-61 21930701-8 2011 The regulation of phosphatidylethanolamine levels by the MSF1 domain is antagonized by the Ups2p LEA-like domain. phosphatidylethanolamine 18-42 Ups2p Saccharomyces cerevisiae S288C 91-96 22325599-5 2012 During autophagy, Atg8 becomes covalently bound to phosphatidylethanolamine (PE) on the pre-autophagosomal membrane and remains bound through the maturation process of the autophagosome. phosphatidylethanolamine 51-75 GABA type A receptor associated protein like 1 Homo sapiens 18-22 22325599-5 2012 During autophagy, Atg8 becomes covalently bound to phosphatidylethanolamine (PE) on the pre-autophagosomal membrane and remains bound through the maturation process of the autophagosome. phosphatidylethanolamine 77-79 GABA type A receptor associated protein like 1 Homo sapiens 18-22 21880860-7 2011 Phosphatidylethanolamine (PE) was also a substrate and the phospholipase A1 (PLA1) activity was dominant over the PLA2 activity. phosphatidylethanolamine 0-24 lipase H Homo sapiens 59-75 21880860-7 2011 Phosphatidylethanolamine (PE) was also a substrate and the phospholipase A1 (PLA1) activity was dominant over the PLA2 activity. phosphatidylethanolamine 0-24 lipase H Homo sapiens 77-81 21880860-7 2011 Phosphatidylethanolamine (PE) was also a substrate and the phospholipase A1 (PLA1) activity was dominant over the PLA2 activity. phosphatidylethanolamine 0-24 phospholipase A2 group IIA Homo sapiens 114-118 21880860-7 2011 Phosphatidylethanolamine (PE) was also a substrate and the phospholipase A1 (PLA1) activity was dominant over the PLA2 activity. phosphatidylethanolamine 26-28 lipase H Homo sapiens 59-75 21880860-7 2011 Phosphatidylethanolamine (PE) was also a substrate and the phospholipase A1 (PLA1) activity was dominant over the PLA2 activity. phosphatidylethanolamine 26-28 lipase H Homo sapiens 77-81 21803774-1 2011 AT1G78690, a gene found in Arabidopsis thaliana, has been reported to encode a N-acyltransferase that transfers an acyl chain from acyl-CoA to the headgroup of phosphatidylethanolamine (PE) to form N-acylphosphatidylethanolamine (N-acyl-PE). phosphatidylethanolamine 160-184 Phospholipid/glycerol acyltransferase family protein Arabidopsis thaliana 0-9 21803774-1 2011 AT1G78690, a gene found in Arabidopsis thaliana, has been reported to encode a N-acyltransferase that transfers an acyl chain from acyl-CoA to the headgroup of phosphatidylethanolamine (PE) to form N-acylphosphatidylethanolamine (N-acyl-PE). phosphatidylethanolamine 186-188 Phospholipid/glycerol acyltransferase family protein Arabidopsis thaliana 0-9 21554544-5 2011 One hypothesis suggests that ABCA4 mediates the trans-bilayer translocation of retinal-phosphatidylethanolamine conjugates to facilitate the retinal regeneration process in the visual cycle. phosphatidylethanolamine 87-111 ATP binding cassette subfamily A member 4 Homo sapiens 29-34 21438724-2 2011 TATp moieties were attached to the surface of these nanocarriers using TATp modified with a conjugate of phosphatidyl ethanolamine with a "short" PEG (PEG-PE). phosphatidylethanolamine 105-130 tyrosine aminotransferase Mus musculus 0-4 21803774-6 2011 In addition, in vitro enzyme assays using both (32)P- and (14)C-radiolabeled substrates showed that AT1G78690 acylates 1-acyllysophosphatidylethanolamine (1-acyllyso-PE) and 1-acyllysophosphatidylglycerol (1-acyllyso-PG), but not PE or phosphatidylglycerol (PG), to form a diacylated product that co-migrates with PE and PG, respectively. phosphatidylethanolamine 166-168 Phospholipid/glycerol acyltransferase family protein Arabidopsis thaliana 100-109 21803774-6 2011 In addition, in vitro enzyme assays using both (32)P- and (14)C-radiolabeled substrates showed that AT1G78690 acylates 1-acyllysophosphatidylethanolamine (1-acyllyso-PE) and 1-acyllysophosphatidylglycerol (1-acyllyso-PG), but not PE or phosphatidylglycerol (PG), to form a diacylated product that co-migrates with PE and PG, respectively. phosphatidylethanolamine 230-232 Phospholipid/glycerol acyltransferase family protein Arabidopsis thaliana 100-109 21803774-7 2011 We analyzed the diacylated product formed by AT1G78690 using a combination of base hydrolysis, phospholipase D treatment, ESI-MS, and MS/MS to show that AT1G78690 acylates the sn-2-position of 1-acyllyso-PE and 1-acyllyso-PG. phosphatidylethanolamine 203-206 Phospholipid/glycerol acyltransferase family protein Arabidopsis thaliana 153-162 21867568-6 2011 Atg8 proteins undergo a unique ubiquitin-like conjugation to phosphatidylethanolamine on the autophagic membrane, a process essential for autophagosome formation. phosphatidylethanolamine 61-85 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 0-4 21940513-10 2011 Treatment of cultured Hep-G2 cells with fructose for 24 h increased the levels of SREBP1 and ChREBP nuclear proteins, which were suppressed by culture with purified PL components, especially phosphatidylethanolamine and phosphatidylinositol. phosphatidylethanolamine 191-215 sterol regulatory element binding transcription factor 1 Homo sapiens 82-88 21940513-10 2011 Treatment of cultured Hep-G2 cells with fructose for 24 h increased the levels of SREBP1 and ChREBP nuclear proteins, which were suppressed by culture with purified PL components, especially phosphatidylethanolamine and phosphatidylinositol. phosphatidylethanolamine 191-215 MLX interacting protein like Homo sapiens 93-99 21784249-2 2011 Atg8, a phosphatidylethanolamine-conjugated protein, was previously proposed to function in autophagosome membrane expansion, based on the observation that it mediates liposome tethering and hemifusion in vitro. phosphatidylethanolamine 8-32 GABA type A receptor associated protein like 1 Homo sapiens 0-4 21784249-3 2011 We show here that with physiological concentrations of phosphatidylethanolamine, Atg8 does not act as a fusogen. phosphatidylethanolamine 55-79 GABA type A receptor associated protein like 1 Homo sapiens 81-85 21610074-7 2011 The ability of syt1 to demix PS is observed in a range of lipid mixtures that includes cholesterol, phosphatidylethanolamine, and varied PS content. phosphatidylethanolamine 100-124 synaptotagmin 1 Homo sapiens 15-19 21494094-5 2011 Fly mutants that bear perturbations in phosphatidylethanolamine (PE) biosynthesis, such as the easily-shocked (eas) mutants defective in ethanolamine kinase, incurred aberrant activation of the sterol regulatory element binding protein (SREBP) pathway, thereby causing chronic lipogenesis and cardiac steatosis that culminates in the development of lipotoxic cardiomyopathy. phosphatidylethanolamine 39-63 easily shocked Drosophila melanogaster 95-109 21494094-5 2011 Fly mutants that bear perturbations in phosphatidylethanolamine (PE) biosynthesis, such as the easily-shocked (eas) mutants defective in ethanolamine kinase, incurred aberrant activation of the sterol regulatory element binding protein (SREBP) pathway, thereby causing chronic lipogenesis and cardiac steatosis that culminates in the development of lipotoxic cardiomyopathy. phosphatidylethanolamine 39-63 easily shocked Drosophila melanogaster 137-156 21494094-5 2011 Fly mutants that bear perturbations in phosphatidylethanolamine (PE) biosynthesis, such as the easily-shocked (eas) mutants defective in ethanolamine kinase, incurred aberrant activation of the sterol regulatory element binding protein (SREBP) pathway, thereby causing chronic lipogenesis and cardiac steatosis that culminates in the development of lipotoxic cardiomyopathy. phosphatidylethanolamine 39-63 Sterol regulatory element binding protein Drosophila melanogaster 194-235 21494094-5 2011 Fly mutants that bear perturbations in phosphatidylethanolamine (PE) biosynthesis, such as the easily-shocked (eas) mutants defective in ethanolamine kinase, incurred aberrant activation of the sterol regulatory element binding protein (SREBP) pathway, thereby causing chronic lipogenesis and cardiac steatosis that culminates in the development of lipotoxic cardiomyopathy. phosphatidylethanolamine 39-63 Sterol regulatory element binding protein Drosophila melanogaster 237-242 21494094-5 2011 Fly mutants that bear perturbations in phosphatidylethanolamine (PE) biosynthesis, such as the easily-shocked (eas) mutants defective in ethanolamine kinase, incurred aberrant activation of the sterol regulatory element binding protein (SREBP) pathway, thereby causing chronic lipogenesis and cardiac steatosis that culminates in the development of lipotoxic cardiomyopathy. phosphatidylethanolamine 65-67 easily shocked Drosophila melanogaster 95-109 21494094-5 2011 Fly mutants that bear perturbations in phosphatidylethanolamine (PE) biosynthesis, such as the easily-shocked (eas) mutants defective in ethanolamine kinase, incurred aberrant activation of the sterol regulatory element binding protein (SREBP) pathway, thereby causing chronic lipogenesis and cardiac steatosis that culminates in the development of lipotoxic cardiomyopathy. phosphatidylethanolamine 65-67 easily shocked Drosophila melanogaster 137-156 21494094-5 2011 Fly mutants that bear perturbations in phosphatidylethanolamine (PE) biosynthesis, such as the easily-shocked (eas) mutants defective in ethanolamine kinase, incurred aberrant activation of the sterol regulatory element binding protein (SREBP) pathway, thereby causing chronic lipogenesis and cardiac steatosis that culminates in the development of lipotoxic cardiomyopathy. phosphatidylethanolamine 65-67 Sterol regulatory element binding protein Drosophila melanogaster 194-235 21494094-5 2011 Fly mutants that bear perturbations in phosphatidylethanolamine (PE) biosynthesis, such as the easily-shocked (eas) mutants defective in ethanolamine kinase, incurred aberrant activation of the sterol regulatory element binding protein (SREBP) pathway, thereby causing chronic lipogenesis and cardiac steatosis that culminates in the development of lipotoxic cardiomyopathy. phosphatidylethanolamine 65-67 Sterol regulatory element binding protein Drosophila melanogaster 237-242 21454556-6 2011 ATP8A2 expressed in HEK293T cells assembles with endogenous or expressed CDC50A, but not CDC50B, to generate a heteromeric complex that actively transports phosphatidylserine and to a lesser extent phosphatidylethanolamine across membranes. phosphatidylethanolamine 198-222 ATPase phospholipid transporting 8A2 Homo sapiens 0-6 21454556-6 2011 ATP8A2 expressed in HEK293T cells assembles with endogenous or expressed CDC50A, but not CDC50B, to generate a heteromeric complex that actively transports phosphatidylserine and to a lesser extent phosphatidylethanolamine across membranes. phosphatidylethanolamine 198-222 transmembrane protein 30A Homo sapiens 73-79 21454708-6 2011 Activity and protein of PE N-methyltransferase (PEMT), which produces PC by methylation of PE, are absent in 3T3-L1 fibroblasts but were induced at day 5. phosphatidylethanolamine 24-26 phosphatidylethanolamine N-methyltransferase Mus musculus 48-52 21454708-13 2011 We conclude that two consecutive processes not previously related to LD biogenesis, (i) PE production via PS and (ii) PE conversion via PEMT, are implicated in LD formation and stability. phosphatidylethanolamine 88-90 phosphatidylethanolamine N-methyltransferase Mus musculus 136-140 21454708-13 2011 We conclude that two consecutive processes not previously related to LD biogenesis, (i) PE production via PS and (ii) PE conversion via PEMT, are implicated in LD formation and stability. phosphatidylethanolamine 118-120 phosphatidylethanolamine N-methyltransferase Mus musculus 136-140 21266583-5 2011 Proteolytic activation of sPLA(2)-X in PLA2G10-Tg skin was accompanied by preferential hydrolysis of phosphatidylethanolamine species with polyunsaturated fatty acids as well as elevated production of some if not all eicosanoids. phosphatidylethanolamine 101-125 phospholipase A2, group X Mus musculus 26-35 21388957-3 2011 The MAP family proteins undergo cleavage of their C-terminal residue(s), and the exposed conserved glycine forms conjugates with phosphatidylethanolamine, which associate with membranes. phosphatidylethanolamine 129-153 regulator of microtubule dynamics 1 Homo sapiens 4-7 21490676-5 2011 Retinal ischemia, induced in adult rats by increasing the intraocular pressure, was characterized by a reduction in the phosphatidylethanolamine-modified form of LC3 (LC3II) and by a significant decrease in Beclin-1. phosphatidylethanolamine 120-144 annexin A3 Rattus norvegicus 162-165 21490676-5 2011 Retinal ischemia, induced in adult rats by increasing the intraocular pressure, was characterized by a reduction in the phosphatidylethanolamine-modified form of LC3 (LC3II) and by a significant decrease in Beclin-1. phosphatidylethanolamine 120-144 annexin A3 Rattus norvegicus 167-172 21266583-5 2011 Proteolytic activation of sPLA(2)-X in PLA2G10-Tg skin was accompanied by preferential hydrolysis of phosphatidylethanolamine species with polyunsaturated fatty acids as well as elevated production of some if not all eicosanoids. phosphatidylethanolamine 101-125 phospholipase A2, group X Mus musculus 39-46 21242590-6 2011 Overexpression of ACSL4 resulted in a markedly increased synthesis of arachidonoyl-CoA, increased 20:4 incorporation into phosphatidylethanolamine, phosphatidylinositol, and triacylglycerol, and reduced cellular levels of unesterified 20:4. phosphatidylethanolamine 122-146 acyl-CoA synthetase long chain family member 4 Homo sapiens 18-23 21306442-1 2011 Mitochondria of the yeast Saccharomyces cerevisiae contain enzymes Crd1p and Psd1p, which synthesize cardiolipin (CL) and phosphatidylethanolamine respectively. phosphatidylethanolamine 122-146 cardiolipin synthase Saccharomyces cerevisiae S288C 67-72 21306442-1 2011 Mitochondria of the yeast Saccharomyces cerevisiae contain enzymes Crd1p and Psd1p, which synthesize cardiolipin (CL) and phosphatidylethanolamine respectively. phosphatidylethanolamine 122-146 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 77-82 21441228-7 2011 After synthesis, LC3 is cleaved to form LC3-I, and upon induction of autophagy, LC3-I is conjugated to the lipid phosphatidylethanolamine to form LC3-II, which is tightly bound to the membrane of the autophagosome. phosphatidylethanolamine 113-137 microtubule associated protein 1 light chain 3 alpha Homo sapiens 17-20 21177865-1 2011 The Atg4 cysteine proteases are required for processing Atg8 for the latter to be conjugated to phosphatidylethanolamine on autophagosomal membranes, a key step in autophagosome biogenesis. phosphatidylethanolamine 96-120 cysteine protease ATG4 Saccharomyces cerevisiae S288C 4-8 21177865-1 2011 The Atg4 cysteine proteases are required for processing Atg8 for the latter to be conjugated to phosphatidylethanolamine on autophagosomal membranes, a key step in autophagosome biogenesis. phosphatidylethanolamine 96-120 GABA type A receptor associated protein like 2 Homo sapiens 56-60 21177434-2 2011 Herein, four 5-LOX-derived lipids comprising 5-hydroxyeicosatetraenoic acid (HETE) attached to phospholipids (PLs), either phosphatidylethanolamine (PE) or phosphatidylcholine (18:0p/5-HETE-PE, 18:1p/5-HETE-PE, 16:0p/5-HETE-PE, and 16:0a/5-HETE-PC), were identified in primary human neutrophils. phosphatidylethanolamine 123-147 arachidonate 5-lipoxygenase Homo sapiens 13-18 21177434-2 2011 Herein, four 5-LOX-derived lipids comprising 5-hydroxyeicosatetraenoic acid (HETE) attached to phospholipids (PLs), either phosphatidylethanolamine (PE) or phosphatidylcholine (18:0p/5-HETE-PE, 18:1p/5-HETE-PE, 16:0p/5-HETE-PE, and 16:0a/5-HETE-PC), were identified in primary human neutrophils. phosphatidylethanolamine 149-151 arachidonate 5-lipoxygenase Homo sapiens 13-18 21177434-2 2011 Herein, four 5-LOX-derived lipids comprising 5-hydroxyeicosatetraenoic acid (HETE) attached to phospholipids (PLs), either phosphatidylethanolamine (PE) or phosphatidylcholine (18:0p/5-HETE-PE, 18:1p/5-HETE-PE, 16:0p/5-HETE-PE, and 16:0a/5-HETE-PC), were identified in primary human neutrophils. phosphatidylethanolamine 190-192 arachidonate 5-lipoxygenase Homo sapiens 13-18 20963507-6 2011 In addition, higher levels of docosahexaenoic acid were found in PtdSer and phosphatidylethanolamine (PtdEtn) from the cerebral cortex of gamma-synuclein null mutant mice. phosphatidylethanolamine 76-100 synuclein, gamma Mus musculus 138-153 21354905-0 2011 [STAT1 and STAT2 participate in growth inhibition of human hepatoma HepG2 cells induced by phosphatidylethanolamine]. phosphatidylethanolamine 91-115 signal transducer and activator of transcription 1 Homo sapiens 1-6 21354905-0 2011 [STAT1 and STAT2 participate in growth inhibition of human hepatoma HepG2 cells induced by phosphatidylethanolamine]. phosphatidylethanolamine 91-115 signal transducer and activator of transcription 2 Homo sapiens 11-16 21354905-1 2011 OBJECTIVE: To investigate the roles of STAT1 and STAT2 in growth inhibition induced by phosphatidylethanolamine (PE) in human hepatoma HepG2 cells. phosphatidylethanolamine 87-111 signal transducer and activator of transcription 1 Homo sapiens 39-44 21354905-1 2011 OBJECTIVE: To investigate the roles of STAT1 and STAT2 in growth inhibition induced by phosphatidylethanolamine (PE) in human hepatoma HepG2 cells. phosphatidylethanolamine 87-111 signal transducer and activator of transcription 2 Homo sapiens 49-54 21354905-1 2011 OBJECTIVE: To investigate the roles of STAT1 and STAT2 in growth inhibition induced by phosphatidylethanolamine (PE) in human hepatoma HepG2 cells. phosphatidylethanolamine 113-115 signal transducer and activator of transcription 1 Homo sapiens 39-44 21354905-1 2011 OBJECTIVE: To investigate the roles of STAT1 and STAT2 in growth inhibition induced by phosphatidylethanolamine (PE) in human hepatoma HepG2 cells. phosphatidylethanolamine 113-115 signal transducer and activator of transcription 2 Homo sapiens 49-54 21354905-3 2011 RESULTS: PE inhibited the growth of HepG2 cells in a dose-dependent manner and increased the expression of STAT1 and STAT2 in comparison with those in the control group. phosphatidylethanolamine 9-11 signal transducer and activator of transcription 1 Homo sapiens 107-112 21354905-3 2011 RESULTS: PE inhibited the growth of HepG2 cells in a dose-dependent manner and increased the expression of STAT1 and STAT2 in comparison with those in the control group. phosphatidylethanolamine 9-11 signal transducer and activator of transcription 2 Homo sapiens 117-122 21354905-5 2011 CONCLUSION: STAT1 and STAT2 are involved in the growth inhibition of human hepatoma HepG2 cells induced by PE. phosphatidylethanolamine 107-109 signal transducer and activator of transcription 1 Homo sapiens 12-17 21354905-5 2011 CONCLUSION: STAT1 and STAT2 are involved in the growth inhibition of human hepatoma HepG2 cells induced by PE. phosphatidylethanolamine 107-109 signal transducer and activator of transcription 2 Homo sapiens 22-27 20963507-6 2011 In addition, higher levels of docosahexaenoic acid were found in PtdSer and phosphatidylethanolamine (PtdEtn) from the cerebral cortex of gamma-synuclein null mutant mice. phosphatidylethanolamine 102-108 synuclein, gamma Mus musculus 138-153 21245170-3 2011 In the present study, we report that the Drosophila easily shocked (eas) mutants that harbor a disturbance in phosphatidylethanolamine (PE) synthesis display tachycardia and defects in cardiac relaxation and are prone to developing cardiac arrest and fibrillation under stress. phosphatidylethanolamine 110-134 easily shocked Drosophila melanogaster 52-66 21245170-3 2011 In the present study, we report that the Drosophila easily shocked (eas) mutants that harbor a disturbance in phosphatidylethanolamine (PE) synthesis display tachycardia and defects in cardiac relaxation and are prone to developing cardiac arrest and fibrillation under stress. phosphatidylethanolamine 136-138 easily shocked Drosophila melanogaster 52-66 21245170-5 2011 Moreover, the low PE levels in eas flies mimic the effects of cholesterol deficiency in vertebrates by stimulating the Drosophila sterol regulatory element-binding protein (dSREBP) pathway. phosphatidylethanolamine 18-20 Sterol regulatory element binding protein Drosophila melanogaster 119-171 21245170-5 2011 Moreover, the low PE levels in eas flies mimic the effects of cholesterol deficiency in vertebrates by stimulating the Drosophila sterol regulatory element-binding protein (dSREBP) pathway. phosphatidylethanolamine 18-20 Sterol regulatory element binding protein Drosophila melanogaster 173-179 20974857-4 2010 Exogenous sPLA(2)-X released lysophospholipid species that arise from phospholipids enriched in AA in eosinophils, including phosphatidylcholine, phosphatidylinositol, and phosphatidylethanolamine as well as plasmenyl phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 172-196 phospholipase A2 group X Homo sapiens 10-19 21415529-3 2011 When MGST1 was mixed with liposomes of cardiolipin (CL), phosphatidylcholine (PC), phosphatidylserine (PC), or phosphatidylethanolamine (PE), its activity was increased in a magnitude which was dependent on the anionic property of lipids in the order of CL>PS>PE>PC, indicating that MGST1 activity is enhanced by surrounding anionic lipids. phosphatidylethanolamine 111-135 microsomal glutathione S-transferase 1 Homo sapiens 5-10 21415529-3 2011 When MGST1 was mixed with liposomes of cardiolipin (CL), phosphatidylcholine (PC), phosphatidylserine (PC), or phosphatidylethanolamine (PE), its activity was increased in a magnitude which was dependent on the anionic property of lipids in the order of CL>PS>PE>PC, indicating that MGST1 activity is enhanced by surrounding anionic lipids. phosphatidylethanolamine 137-139 microsomal glutathione S-transferase 1 Homo sapiens 5-10 21738695-0 2011 Key amino acid residues of ankyrin-sensitive phosphatidylethanolamine/phosphatidylcholine-lipid binding site of betaI-spectrin. phosphatidylethanolamine 45-69 spectrin beta, erythrocytic Homo sapiens 112-126 21074554-1 2011 A phospholipase A2 was identified from MDCK cell homogenates with broad specificity toward glycerophospholipids including phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and phosphatidylglycerol. phosphatidylethanolamine 143-167 phospholipase A2 group IB Canis lupus familiaris 2-18 21130733-11 2011 Liposome-binding experiments demonstrate that BoNT/CD-HCR binds phosphatidylethanolamine liposomes more tightly than BoNT/D-HCR. phosphatidylethanolamine 64-88 C-C motif chemokine receptor like 2 Homo sapiens 54-57 20974857-4 2010 Exogenous sPLA(2)-X released lysophospholipid species that arise from phospholipids enriched in AA in eosinophils, including phosphatidylcholine, phosphatidylinositol, and phosphatidylethanolamine as well as plasmenyl phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 242-266 phospholipase A2 group X Homo sapiens 10-19 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). phosphatidylethanolamine 40-42 phosphatidylethanolamine N-methyltransferase Homo sapiens 101-105 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). phosphatidylethanolamine 44-68 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). phosphatidylethanolamine 40-42 phosphatidylethanolamine N-methyltransferase Homo sapiens 107-129 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). phosphatidylethanolamine 44-68 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). phosphatidylethanolamine 40-42 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). phosphatidylethanolamine 40-42 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). phosphatidylethanolamine 40-42 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). phosphatidylethanolamine 40-42 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). phosphatidylethanolamine 44-68 phosphatidylethanolamine N-methyltransferase Homo sapiens 101-105 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). phosphatidylethanolamine 44-68 phosphatidylethanolamine N-methyltransferase Homo sapiens 107-129 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). phosphatidylethanolamine 44-68 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20860552-1 2010 The enzyme catalysing the conversion of PE (phosphatidylethanolamine) into PC (phosphatidylcholine), PEMT (PE N-methyltransferase), exists as two isoforms, PEMT-L (longer isoform of PEMT) and PEMT-S (shorter isoform of PEMT). phosphatidylethanolamine 44-68 phosphatidylethanolamine N-methyltransferase Homo sapiens 156-160 20858456-8 2010 Liposome-binding experiments with BoNT/D-HCR demonstrate that this membrane lipid may be phosphatidylethanolamine. phosphatidylethanolamine 89-113 coiled-coil alpha-helical rod protein 1 Homo sapiens 41-44 21365919-5 2010 Huh7 or HepG2 cells was transiently transfected with HBV expression vector pHBV1.3, then the phosphatidylethanol-amine conjugation of microtubule-associated protein 3 (LC3) and the degradation of p62, both of which are specific indictors of autophagy,were evaluated by western blot. phosphatidylethanolamine 93-118 MIR7-3 host gene Homo sapiens 0-4 21044591-3 2010 Here we present experiments, in which phosphatidylserine (PS) and phosphatidylethanolamine (PE) were added to mixtures of PC/cholesterol in different proportions in the Syb2 vesicle membranes only or in both the supported bilayers and the Syb2 vesicles. phosphatidylethanolamine 92-94 vesicle associated membrane protein 2 Homo sapiens 169-173 20724821-4 2010 The new Gly-terminal residue from Atg8 is activated by Atg7 (an E1-like enzyme) then transferred to Atg3 (an E2-like enzyme) and finally conjugated with membrane-bound phosphatidylethanolamine (PE) through an amide bond. phosphatidylethanolamine 168-192 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 34-38 20724821-4 2010 The new Gly-terminal residue from Atg8 is activated by Atg7 (an E1-like enzyme) then transferred to Atg3 (an E2-like enzyme) and finally conjugated with membrane-bound phosphatidylethanolamine (PE) through an amide bond. phosphatidylethanolamine 168-192 Atg7p Saccharomyces cerevisiae S288C 55-59 20724821-4 2010 The new Gly-terminal residue from Atg8 is activated by Atg7 (an E1-like enzyme) then transferred to Atg3 (an E2-like enzyme) and finally conjugated with membrane-bound phosphatidylethanolamine (PE) through an amide bond. phosphatidylethanolamine 168-192 Atg3p Saccharomyces cerevisiae S288C 100-104 20724821-4 2010 The new Gly-terminal residue from Atg8 is activated by Atg7 (an E1-like enzyme) then transferred to Atg3 (an E2-like enzyme) and finally conjugated with membrane-bound phosphatidylethanolamine (PE) through an amide bond. phosphatidylethanolamine 194-196 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 34-38 20724821-4 2010 The new Gly-terminal residue from Atg8 is activated by Atg7 (an E1-like enzyme) then transferred to Atg3 (an E2-like enzyme) and finally conjugated with membrane-bound phosphatidylethanolamine (PE) through an amide bond. phosphatidylethanolamine 194-196 Atg7p Saccharomyces cerevisiae S288C 55-59 20724821-4 2010 The new Gly-terminal residue from Atg8 is activated by Atg7 (an E1-like enzyme) then transferred to Atg3 (an E2-like enzyme) and finally conjugated with membrane-bound phosphatidylethanolamine (PE) through an amide bond. phosphatidylethanolamine 194-196 Atg3p Saccharomyces cerevisiae S288C 100-104 20519644-4 2010 We determined the crystal structure of one of the three expressed bovine CD1b proteins, CD1b3, in complex with endogenous ligands, identified by mass spectrometry as a mixture of phosphatidylcholine and phosphatidylethanolamine, and analyzed the ability of the protein to bind glycolipids in vitro. phosphatidylethanolamine 203-227 CD1b molecule Bos taurus 73-77 20589634-2 2010 Similarly to homologous CD1d, EPCR binds a phospholipid [phosphatidylethanolamine (PTY)] in a groove corresponding to the antigen-presenting site, although it is not clear if lipid exchange can occur in EPCR as in CD1d. phosphatidylethanolamine 57-81 protein C receptor Homo sapiens 30-34 20589634-2 2010 Similarly to homologous CD1d, EPCR binds a phospholipid [phosphatidylethanolamine (PTY)] in a groove corresponding to the antigen-presenting site, although it is not clear if lipid exchange can occur in EPCR as in CD1d. phosphatidylethanolamine 83-86 protein C receptor Homo sapiens 30-34 20427062-1 2010 The CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2) regulates the synthesis of CDP-ethanolamine, which is combined with diacylglycerol (DAG) to form the membrane phospholipid phosphatidylethanolamine (PE) via the de novo Kennedy pathway. phosphatidylethanolamine 185-209 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 4-48 20427062-1 2010 The CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2) regulates the synthesis of CDP-ethanolamine, which is combined with diacylglycerol (DAG) to form the membrane phospholipid phosphatidylethanolamine (PE) via the de novo Kennedy pathway. phosphatidylethanolamine 185-209 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 55-60 20427062-1 2010 The CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2) regulates the synthesis of CDP-ethanolamine, which is combined with diacylglycerol (DAG) to form the membrane phospholipid phosphatidylethanolamine (PE) via the de novo Kennedy pathway. phosphatidylethanolamine 211-213 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 4-48 20427062-1 2010 The CTP:phosphoethanolamine cytidylyltransferase gene (Pcyt2) regulates the synthesis of CDP-ethanolamine, which is combined with diacylglycerol (DAG) to form the membrane phospholipid phosphatidylethanolamine (PE) via the de novo Kennedy pathway. phosphatidylethanolamine 211-213 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 55-60 20427062-2 2010 [14C]Ethanolamine and [3H]glycerol radiolabeling experiments established that PE synthesis and turnover are reduced in primary hepatocytes isolated from Pcyt2-deficient (Pcyt2+/-) mice relative to littermate controls. phosphatidylethanolamine 78-80 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 153-158 20427062-2 2010 [14C]Ethanolamine and [3H]glycerol radiolabeling experiments established that PE synthesis and turnover are reduced in primary hepatocytes isolated from Pcyt2-deficient (Pcyt2+/-) mice relative to littermate controls. phosphatidylethanolamine 78-80 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 170-175 20855502-5 2010 Atg8 coupled to phosphatidylethanolamine (PE) is crucial for autophagosome elongation and, in vitro, mediates tethering and hemifusion. phosphatidylethanolamine 16-40 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 0-4 20855502-5 2010 Atg8 coupled to phosphatidylethanolamine (PE) is crucial for autophagosome elongation and, in vitro, mediates tethering and hemifusion. phosphatidylethanolamine 42-44 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 0-4 20615880-3 2010 Atg3 is an E2-like enzyme that conjugates Atg8 with phosphatidylethanolamine. phosphatidylethanolamine 52-76 Atg3p Saccharomyces cerevisiae S288C 0-4 20615880-3 2010 Atg3 is an E2-like enzyme that conjugates Atg8 with phosphatidylethanolamine. phosphatidylethanolamine 52-76 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 42-46 20615880-7 2010 In vitro analyses showed that Atg3 AIM is crucial for the transfer of Atg8 from the Atg8~Atg3 thioester intermediate to phosphatidylethanolamine but not for the formation of the intermediate. phosphatidylethanolamine 120-144 Atg3p Saccharomyces cerevisiae S288C 30-34 20615880-7 2010 In vitro analyses showed that Atg3 AIM is crucial for the transfer of Atg8 from the Atg8~Atg3 thioester intermediate to phosphatidylethanolamine but not for the formation of the intermediate. phosphatidylethanolamine 120-144 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 70-74 20615880-7 2010 In vitro analyses showed that Atg3 AIM is crucial for the transfer of Atg8 from the Atg8~Atg3 thioester intermediate to phosphatidylethanolamine but not for the formation of the intermediate. phosphatidylethanolamine 120-144 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 84-88 20615880-7 2010 In vitro analyses showed that Atg3 AIM is crucial for the transfer of Atg8 from the Atg8~Atg3 thioester intermediate to phosphatidylethanolamine but not for the formation of the intermediate. phosphatidylethanolamine 120-144 Atg3p Saccharomyces cerevisiae S288C 89-93 20574160-3 2010 In particular, two ubiquitin-like proteins, ATG8 and ATG12, which conjugate with phosphatidylethanolamine (PE) and ATG5, respectively, forming ATG8-PE and ATG12-ATG5 complexes, were shown to be essential in autophagosome formation. phosphatidylethanolamine 81-105 autophagy protein Apg5 family Arabidopsis thaliana 115-119 20574160-3 2010 In particular, two ubiquitin-like proteins, ATG8 and ATG12, which conjugate with phosphatidylethanolamine (PE) and ATG5, respectively, forming ATG8-PE and ATG12-ATG5 complexes, were shown to be essential in autophagosome formation. phosphatidylethanolamine 81-105 autophagy protein Apg5 family Arabidopsis thaliana 161-165 20574160-3 2010 In particular, two ubiquitin-like proteins, ATG8 and ATG12, which conjugate with phosphatidylethanolamine (PE) and ATG5, respectively, forming ATG8-PE and ATG12-ATG5 complexes, were shown to be essential in autophagosome formation. phosphatidylethanolamine 107-109 autophagy protein Apg5 family Arabidopsis thaliana 115-119 20574160-3 2010 In particular, two ubiquitin-like proteins, ATG8 and ATG12, which conjugate with phosphatidylethanolamine (PE) and ATG5, respectively, forming ATG8-PE and ATG12-ATG5 complexes, were shown to be essential in autophagosome formation. phosphatidylethanolamine 107-109 autophagy protein Apg5 family Arabidopsis thaliana 161-165 20574160-4 2010 Our recent findings reveal that the Arabidopsis thaliana acyl-CoA-binding protein ACBP3 binds the phospholipid PE in vitro and that ACBP3 overexpression and downregulation correlate with PE composition in rosettes. phosphatidylethanolamine 111-113 acyl-CoA-binding domain 3 Arabidopsis thaliana 82-87 20574160-4 2010 Our recent findings reveal that the Arabidopsis thaliana acyl-CoA-binding protein ACBP3 binds the phospholipid PE in vitro and that ACBP3 overexpression and downregulation correlate with PE composition in rosettes. phosphatidylethanolamine 111-113 acyl-CoA-binding domain 3 Arabidopsis thaliana 132-137 20574160-4 2010 Our recent findings reveal that the Arabidopsis thaliana acyl-CoA-binding protein ACBP3 binds the phospholipid PE in vitro and that ACBP3 overexpression and downregulation correlate with PE composition in rosettes. phosphatidylethanolamine 187-189 acyl-CoA-binding domain 3 Arabidopsis thaliana 82-87 20574160-4 2010 Our recent findings reveal that the Arabidopsis thaliana acyl-CoA-binding protein ACBP3 binds the phospholipid PE in vitro and that ACBP3 overexpression and downregulation correlate with PE composition in rosettes. phosphatidylethanolamine 187-189 acyl-CoA-binding domain 3 Arabidopsis thaliana 132-137 20452975-2 2010 Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 69-93 phosphatidylethanolamine N-methyltransferase Mus musculus 108-152 20452975-2 2010 Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 69-93 phosphatidylethanolamine N-methyltransferase Mus musculus 154-158 20519644-4 2010 We determined the crystal structure of one of the three expressed bovine CD1b proteins, CD1b3, in complex with endogenous ligands, identified by mass spectrometry as a mixture of phosphatidylcholine and phosphatidylethanolamine, and analyzed the ability of the protein to bind glycolipids in vitro. phosphatidylethanolamine 203-227 CD1b molecule Bos taurus 88-93 20503434-2 2010 In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively. phosphatidylethanolamine 33-35 cut like homeobox 1 Homo sapiens 144-147 20418806-1 2010 Autophagy, a critical process for bulk degradation of proteins and organelles, requires conjugation of Atg8 proteins to phosphatidylethanolamine on the autophagic membrane. phosphatidylethanolamine 120-144 GABA type A receptor associated protein like 2 Homo sapiens 103-107 20345632-6 2010 *On lipid and acyl-CoA analyses, the siliques, but not the leaves, of the acbp1 mutant accumulated galactolipid monogalactosyldiacylglycerol and 18:0-CoA, but the levels of most polyunsaturated species of phospholipid, such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol and phosphatidylserine, declined. phosphatidylethanolamine 248-272 acyl-CoA binding protein 1 Arabidopsis thaliana 74-79 20382112-4 2010 Therefore, a multistage conjugation process of newly synthesized Atg8 to phosphatidylethanolamine is of critical importance. phosphatidylethanolamine 73-97 GABA type A receptor associated protein like 1 Homo sapiens 65-69 20364109-2 2010 Autophagosomal membranes harbor the lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) and phosphatidylethanolamine-conjugated ATG8/LC3/GABARAP family proteins. phosphatidylethanolamine 92-116 GABA type A receptor associated protein like 1 Homo sapiens 128-132 20364109-2 2010 Autophagosomal membranes harbor the lipid phosphatidylinositol-3-phosphate (PtdIns(3)P) and phosphatidylethanolamine-conjugated ATG8/LC3/GABARAP family proteins. phosphatidylethanolamine 92-116 microtubule associated protein 1 light chain 3 alpha Homo sapiens 133-136 20442372-4 2010 Acyl-CoA and lipid profiling revealed that the overexpression of ACBP3 led to an increase in acyl-CoA and phosphatidylethanolamine (PE) levels, whereas ACBP3 downregulation reduced PE content. phosphatidylethanolamine 106-130 acyl-CoA-binding domain 3 Arabidopsis thaliana 65-70 20442372-4 2010 Acyl-CoA and lipid profiling revealed that the overexpression of ACBP3 led to an increase in acyl-CoA and phosphatidylethanolamine (PE) levels, whereas ACBP3 downregulation reduced PE content. phosphatidylethanolamine 132-134 acyl-CoA-binding domain 3 Arabidopsis thaliana 65-70 20442372-4 2010 Acyl-CoA and lipid profiling revealed that the overexpression of ACBP3 led to an increase in acyl-CoA and phosphatidylethanolamine (PE) levels, whereas ACBP3 downregulation reduced PE content. phosphatidylethanolamine 181-183 acyl-CoA-binding domain 3 Arabidopsis thaliana 65-70 20442372-8 2010 Observations that recombinant ACBP3 binds PC, PE, and unsaturated acyl-CoAs in vitro and that ACBP3 overexpression enhances degradation of the autophagy (ATG)-related protein ATG8 and disrupts autophagosome formation suggest a role for ACBP3 as a phospholipid binding protein involved in the regulation of leaf senescence by modulating membrane phospholipid metabolism and ATG8 stability in Arabidopsis. phosphatidylethanolamine 46-48 acyl-CoA-binding domain 3 Arabidopsis thaliana 30-35 20044027-3 2010 Deletion of PSD1 and/or PSD2 led to depletion of total cellular and plasma membrane PE level, whereas mutation in the other pathways had practically no effect. phosphatidylethanolamine 84-86 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 12-16 20044027-3 2010 Deletion of PSD1 and/or PSD2 led to depletion of total cellular and plasma membrane PE level, whereas mutation in the other pathways had practically no effect. phosphatidylethanolamine 84-86 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 24-28 20045741-1 2010 The rate-limiting step in phosphatidylethanolamine (PE) synthesis by the CDP-ethanolamine pathway is the second step, which is catalyzed by CTP:phosphoethanolamine cytidylyltransferase (ET). phosphatidylethanolamine 26-50 cut-like homeobox 1 Mus musculus 73-76 20045741-1 2010 The rate-limiting step in phosphatidylethanolamine (PE) synthesis by the CDP-ethanolamine pathway is the second step, which is catalyzed by CTP:phosphoethanolamine cytidylyltransferase (ET). phosphatidylethanolamine 26-50 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 140-184 20045741-1 2010 The rate-limiting step in phosphatidylethanolamine (PE) synthesis by the CDP-ethanolamine pathway is the second step, which is catalyzed by CTP:phosphoethanolamine cytidylyltransferase (ET). phosphatidylethanolamine 52-54 cut-like homeobox 1 Mus musculus 73-76 20045741-1 2010 The rate-limiting step in phosphatidylethanolamine (PE) synthesis by the CDP-ethanolamine pathway is the second step, which is catalyzed by CTP:phosphoethanolamine cytidylyltransferase (ET). phosphatidylethanolamine 52-54 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 140-184 20503434-2 2010 In most eukaryotic cells, PC and PE are synthesized by an aminoalcoholphosphotransferase reaction, which uses sn-1,2-diradylglycerol and either CDP-choline or CDP-ethanolamine, respectively. phosphatidylethanolamine 33-35 cut like homeobox 1 Homo sapiens 159-162 19889625-2 2010 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the biosynthesis of phosphatidylcholine from phosphatidylethanolamine enriched in DHA and many humans have functional genetic polymorphisms in the PEMT gene. phosphatidylethanolamine 107-131 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-44 20024669-0 2010 Specific induction of TaAAPT1, an ER- and Golgi-localized ECPT-type aminoalcoholphosphotransferase, results in preferential accumulation of the phosphatidylethanolamine membrane phospholipid during cold acclimation in wheat. phosphatidylethanolamine 144-168 choline/ethanolaminephosphotransferase 1 Triticum aestivum 22-29 20024669-7 2010 Transient expression of GFP-fused TaAAPT1 and TaAAPT2 proteins in wheat and onion cells indicated they are localized to both the endoplasmic reticulum and Golgi apparatus, suggesting that the final synthesis of PE and PC via the CDP-choline/ethanolamine pathway occurs in these organella. phosphatidylethanolamine 211-213 choline/ethanolaminephosphotransferase 1 Triticum aestivum 34-41 20024669-7 2010 Transient expression of GFP-fused TaAAPT1 and TaAAPT2 proteins in wheat and onion cells indicated they are localized to both the endoplasmic reticulum and Golgi apparatus, suggesting that the final synthesis of PE and PC via the CDP-choline/ethanolamine pathway occurs in these organella. phosphatidylethanolamine 211-213 choline/ethanolaminephosphotransferase 1 Triticum aestivum 46-53 20016005-8 2010 We demonstrate that Pdr17 and Psd2 form a complex in vivo that seems essential for maintenance of vacuolar PE levels. phosphatidylethanolamine 107-109 phosphatidylinositol transporter Saccharomyces cerevisiae S288C 20-25 20016005-8 2010 We demonstrate that Pdr17 and Psd2 form a complex in vivo that seems essential for maintenance of vacuolar PE levels. phosphatidylethanolamine 107-109 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 30-34 20016005-2 2010 Saccharomyces cerevisiae has two different phosphatidylserine decarboxylase enzymes (Psd1 and Psd2) that catalyze formation of phosphatidylethanolamine. phosphatidylethanolamine 127-151 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 85-89 20016005-2 2010 Saccharomyces cerevisiae has two different phosphatidylserine decarboxylase enzymes (Psd1 and Psd2) that catalyze formation of phosphatidylethanolamine. phosphatidylethanolamine 127-151 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 94-98 20016005-3 2010 The mitochondrial Psd1 provides roughly 70% of the phosphatidylethanolamine (PE) biosynthesis in the cell with Psd2 carrying out the remainder. phosphatidylethanolamine 51-75 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 18-22 20016005-3 2010 The mitochondrial Psd1 provides roughly 70% of the phosphatidylethanolamine (PE) biosynthesis in the cell with Psd2 carrying out the remainder. phosphatidylethanolamine 77-79 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 18-22 20016005-6 2010 Measurement of phospholipid levels indicates that loss of Psd2 causes a specific reduction in vacuolar membrane PE levels, whereas total PE levels are not significantly affected. phosphatidylethanolamine 112-114 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 58-62 19889625-2 2010 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the biosynthesis of phosphatidylcholine from phosphatidylethanolamine enriched in DHA and many humans have functional genetic polymorphisms in the PEMT gene. phosphatidylethanolamine 107-131 phosphatidylethanolamine N-methyltransferase Homo sapiens 46-50 19889625-2 2010 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the biosynthesis of phosphatidylcholine from phosphatidylethanolamine enriched in DHA and many humans have functional genetic polymorphisms in the PEMT gene. phosphatidylethanolamine 107-131 phosphatidylethanolamine N-methyltransferase Homo sapiens 209-213 20061800-2 2010 LC3, a ubiquitin-like protein, plays an essential role in autophagy through its ability to be conjugated to phosphatidylethanolamine. phosphatidylethanolamine 108-132 microtubule associated protein 1 light chain 3 alpha Homo sapiens 0-3 20072884-2 2010 PEG chains were incorporated into the liposome membrane via the PEG-attached phosphatidylethanolamine (PE) residue with PEG and PE being conjugated with the lowered pH-degradable hydrazone bond (PEG-HZ-PE), while cell-penetrating peptide (TATp) was added as TATp-PEG-PE conjugate. phosphatidylethanolamine 0-2 tyrosine aminotransferase Mus musculus 239-243 20700714-3 2010 During autophagy, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes, and LC3-II is degraded by lysosomal hydrolases after the fusion of autophagosomes with lysosomes. phosphatidylethanolamine 67-91 microtubule associated protein 1 light chain 3 alpha Homo sapiens 38-41 20700714-3 2010 During autophagy, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes, and LC3-II is degraded by lysosomal hydrolases after the fusion of autophagosomes with lysosomes. phosphatidylethanolamine 67-91 microtubule associated protein 1 light chain 3 alpha Homo sapiens 43-48 20700714-3 2010 During autophagy, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes, and LC3-II is degraded by lysosomal hydrolases after the fusion of autophagosomes with lysosomes. phosphatidylethanolamine 67-91 microtubule associated protein 1 light chain 3 alpha Homo sapiens 43-46 20072884-2 2010 PEG chains were incorporated into the liposome membrane via the PEG-attached phosphatidylethanolamine (PE) residue with PEG and PE being conjugated with the lowered pH-degradable hydrazone bond (PEG-HZ-PE), while cell-penetrating peptide (TATp) was added as TATp-PEG-PE conjugate. phosphatidylethanolamine 0-2 tyrosine aminotransferase Mus musculus 258-262 20700714-3 2010 During autophagy, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes, and LC3-II is degraded by lysosomal hydrolases after the fusion of autophagosomes with lysosomes. phosphatidylethanolamine 67-91 microtubule associated protein 1 light chain 3 alpha Homo sapiens 43-46 20700714-3 2010 During autophagy, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes, and LC3-II is degraded by lysosomal hydrolases after the fusion of autophagosomes with lysosomes. phosphatidylethanolamine 67-91 microtubule associated protein 1 light chain 3 alpha Homo sapiens 43-46 19497293-5 2009 Based on these results, an assay for determining the activity of phospholipase D (PLD) toward natural phospholipids such as PC, PE, and PG was developed. phosphatidylethanolamine 128-130 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 65-80 19625253-3 2009 In the current investigation, we show that the reduced CDP-ethanolamine formation in Pcyt2(+/-) mice limits the rate of PE synthesis and increases the availability of diacylglycerol. phosphatidylethanolamine 120-122 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 85-90 19625253-5 2009 Pcyt2(+/-) mice progressively accumulate more diacylglycerol and triglycerides with age and have modified fatty acid composition, predominantly in PE and triglycerides. phosphatidylethanolamine 147-149 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 0-5 19615464-5 2009 In addition, HRASLS2 catalyzed N-acylation of PE to form N-acyl-PE and O-acylation of lyso PC to form PC. phosphatidylethanolamine 46-48 phospholipase A and acyltransferase 2 Homo sapiens 13-20 19915887-7 2009 The phosphatidylethanolamine saturated to polyunsaturated fatty acid ratio showed highly significant positive correlations with the EDSS and CRP < 5 microg/ml. phosphatidylethanolamine 4-28 C-reactive protein Homo sapiens 141-144 19778899-5 2009 Atp8a2 purified from photoreceptor outer segments by immunoaffinity chromatography exhibited ATPase activity that was stimulated by phosphatidylserine and to a lesser degree phosphatidylethanolamine but not by phosphatidylcholine or other membrane lipids. phosphatidylethanolamine 174-198 ATPase phospholipid transporting 8A2 Homo sapiens 0-6 19454128-4 2009 The elongation product of 20 : 4n-6, 22 : 4n-6, was significantly decreased in membrane phosphatidylethanolamine and phosphatidylserine in multiple sclerosis patients (P = 0.01 and P = 0.03 respectively), and correlated inversely with severity of disease and C-reactive protein. phosphatidylethanolamine 88-112 C-reactive protein Homo sapiens 259-277 19715685-7 2009 Furthermore, it was found that NAPE-PLD was activated by phosphatidylethanolamine and inhibited by the beta-lactamase substrate nitrocefin. phosphatidylethanolamine 57-81 N-acyl phosphatidylethanolamine phospholipase D Homo sapiens 31-39 19713737-1 2009 The Atg4 family of endopeptidases regulates autophagosome biogenesis by priming newly synthesized Atg8 to enable covalent attachment of phosphatidylethanolamine, and by delipidating Atg8 at the lysosomal fusion step. phosphatidylethanolamine 136-160 GABA type A receptor associated protein like 1 Homo sapiens 98-102 19497293-5 2009 Based on these results, an assay for determining the activity of phospholipase D (PLD) toward natural phospholipids such as PC, PE, and PG was developed. phosphatidylethanolamine 128-130 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 82-85 18989753-1 2009 The products of mammalian LPIN2 and LPIN3 are phosphatidate phosphatase type 1 enzymes, which play an important role in the de novo biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 189-213 lipin 2 Homo sapiens 26-31 19520976-7 2009 The molar ratio of PC/phosphatidylethanolamine in nascent VLDLs produced by Pemt(-/-)/Ldlr(-/-) mice was lower than in VLDLs in Pemt(+/+)/Ldlr(-/-) mice. phosphatidylethanolamine 22-46 phosphatidylethanolamine N-methyltransferase Mus musculus 76-80 19566678-6 2009 Mutant huntingtin associated more with phosphatidylethanolamine and PI(3,4,5)P3 than did wild-type huntingtin, and associated with other phospholipids not recognized by wild-type huntingtin. phosphatidylethanolamine 39-63 huntingtin Mus musculus 7-17 18989753-1 2009 The products of mammalian LPIN2 and LPIN3 are phosphatidate phosphatase type 1 enzymes, which play an important role in the de novo biosynthesis of triacylglycerol, phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 189-213 lipin 3 Homo sapiens 36-41 19564817-1 2009 BACKGROUND: The phosphatidylethanolamine-binding protein (PEBP/RKIP), initially found to bind phosphatidylethanolamine (PE), has been shown to be associated with morphine derivatives. phosphatidylethanolamine 16-40 phosphatidylethanolamine binding protein 1 Bos taurus 58-62 19417210-5 2009 Atg7 is required for the conjugation of Atg12 to Atg5, and Atg8 to phosphatidylethanolamine (PE), and is essential for autophagosome formation. phosphatidylethanolamine 67-91 autophagy related 7 Homo sapiens 0-4 19417210-5 2009 Atg7 is required for the conjugation of Atg12 to Atg5, and Atg8 to phosphatidylethanolamine (PE), and is essential for autophagosome formation. phosphatidylethanolamine 67-91 GABA type A receptor associated protein like 1 Homo sapiens 59-63 19417210-5 2009 Atg7 is required for the conjugation of Atg12 to Atg5, and Atg8 to phosphatidylethanolamine (PE), and is essential for autophagosome formation. phosphatidylethanolamine 93-95 autophagy related 7 Homo sapiens 0-4 19417210-5 2009 Atg7 is required for the conjugation of Atg12 to Atg5, and Atg8 to phosphatidylethanolamine (PE), and is essential for autophagosome formation. phosphatidylethanolamine 93-95 autophagy related 12 Homo sapiens 40-45 19417210-5 2009 Atg7 is required for the conjugation of Atg12 to Atg5, and Atg8 to phosphatidylethanolamine (PE), and is essential for autophagosome formation. phosphatidylethanolamine 93-95 GABA type A receptor associated protein like 1 Homo sapiens 59-63 19551145-4 2009 NMR studies show that a locostatin precursor binds to the conserved phosphatidylethanolamine binding pocket of RKIP. phosphatidylethanolamine 68-92 phosphatidylethanolamine binding protein 1 Homo sapiens 111-115 19322194-1 2009 Atg8 is conjugated to phosphatidylethanolamine (PE) by ubiquitin-like conjugation reactions. phosphatidylethanolamine 22-46 GABA type A receptor associated protein like 1 Homo sapiens 0-4 19322194-1 2009 Atg8 is conjugated to phosphatidylethanolamine (PE) by ubiquitin-like conjugation reactions. phosphatidylethanolamine 48-50 GABA type A receptor associated protein like 1 Homo sapiens 0-4 19322194-7 2009 At the same time, the N-terminal tail masking the exit of the active site of HsAtg4B in the free form is detached from the enzyme core and a large flat surface is exposed, which might enable the enzyme to access the membrane-bound LC3-PE. phosphatidylethanolamine 235-237 microtubule associated protein 1 light chain 3 alpha Homo sapiens 231-234 19830909-1 2009 In the yeast Saccharomyces cerevisiae three pathways lead to the formation of phosphatidylethanolamine (PE), namely decarboxylation of phosphatidylserine (PS) (i) by Psd1p in mitochondria, and (ii) by Psd2p in a Golgi/vacuolar compartment; and (iii) synthesis via CDP-ethanolamine pathway in the endoplasmic reticulum. phosphatidylethanolamine 78-102 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 166-171 19830909-1 2009 In the yeast Saccharomyces cerevisiae three pathways lead to the formation of phosphatidylethanolamine (PE), namely decarboxylation of phosphatidylserine (PS) (i) by Psd1p in mitochondria, and (ii) by Psd2p in a Golgi/vacuolar compartment; and (iii) synthesis via CDP-ethanolamine pathway in the endoplasmic reticulum. phosphatidylethanolamine 78-102 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 201-206 19830909-1 2009 In the yeast Saccharomyces cerevisiae three pathways lead to the formation of phosphatidylethanolamine (PE), namely decarboxylation of phosphatidylserine (PS) (i) by Psd1p in mitochondria, and (ii) by Psd2p in a Golgi/vacuolar compartment; and (iii) synthesis via CDP-ethanolamine pathway in the endoplasmic reticulum. phosphatidylethanolamine 104-106 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 166-171 19830909-1 2009 In the yeast Saccharomyces cerevisiae three pathways lead to the formation of phosphatidylethanolamine (PE), namely decarboxylation of phosphatidylserine (PS) (i) by Psd1p in mitochondria, and (ii) by Psd2p in a Golgi/vacuolar compartment; and (iii) synthesis via CDP-ethanolamine pathway in the endoplasmic reticulum. phosphatidylethanolamine 104-106 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 201-206 19721378-5 2009 It was demonstrated that different phospholipids have individual effect on membrane-apolipoprotein A-I (apoA-I) interactions that bring about a discoidal lipid-protein complex formation: Phosphatidylethanolamine, possessing the negative spontaneous curvature, increases both the degree of hydration at the membrane interface and the acyl chain order, and enhances the binding of amphipathic helices. phosphatidylethanolamine 187-211 apolipoprotein A1 Homo sapiens 75-102 19721378-5 2009 It was demonstrated that different phospholipids have individual effect on membrane-apolipoprotein A-I (apoA-I) interactions that bring about a discoidal lipid-protein complex formation: Phosphatidylethanolamine, possessing the negative spontaneous curvature, increases both the degree of hydration at the membrane interface and the acyl chain order, and enhances the binding of amphipathic helices. phosphatidylethanolamine 187-211 apolipoprotein A1 Homo sapiens 104-110 19657017-4 2009 When expressed in Saccharomyces cerevisiae, FetA localizes partially to the plasma membrane resulting in increased internalization of NBD-labeled phosphatidylethanolamine and phosphatidylcholine, supporting a role for FetA in the inward lipid translocation across cellular membranes. phosphatidylethanolamine 146-170 ATPase, class I, type 8B, member 5 Mus musculus 44-48 19360919-0 2009 Exogenous phosphatidylethanolamine induces apoptosis of human hepatoma HepG2 cells via the bcl-2/Bax pathway. phosphatidylethanolamine 10-34 BCL2 apoptosis regulator Homo sapiens 91-96 19360919-0 2009 Exogenous phosphatidylethanolamine induces apoptosis of human hepatoma HepG2 cells via the bcl-2/Bax pathway. phosphatidylethanolamine 10-34 BCL2 associated X, apoptosis regulator Homo sapiens 97-100 19360919-4 2009 Immunocytochemical assay and Western blotting were used to examine Bcl-2, Bax and caspase-3 protein levels in HepG2 cells treated with PE. phosphatidylethanolamine 135-137 BCL2 apoptosis regulator Homo sapiens 67-72 19360919-4 2009 Immunocytochemical assay and Western blotting were used to examine Bcl-2, Bax and caspase-3 protein levels in HepG2 cells treated with PE. phosphatidylethanolamine 135-137 BCL2 associated X, apoptosis regulator Homo sapiens 74-77 19360919-4 2009 Immunocytochemical assay and Western blotting were used to examine Bcl-2, Bax and caspase-3 protein levels in HepG2 cells treated with PE. phosphatidylethanolamine 135-137 caspase 3 Homo sapiens 82-91 19360919-11 2009 CONCLUSION: Exogenous PE induces apoptosis of human hepatoma HepG2 cells via the bcl-2/bax pathway. phosphatidylethanolamine 22-24 BCL2 apoptosis regulator Homo sapiens 81-86 19360919-11 2009 CONCLUSION: Exogenous PE induces apoptosis of human hepatoma HepG2 cells via the bcl-2/bax pathway. phosphatidylethanolamine 22-24 BCL2 associated X, apoptosis regulator Homo sapiens 87-90 18979094-0 2009 Influence of surfactant protein C on the interfacial behavior of phosphatidylethanolamine monolayers. phosphatidylethanolamine 65-89 surfactant protein C Homo sapiens 13-33 19285500-0 2009 The amino-terminal region of Atg3 is essential for association with phosphatidylethanolamine in Atg8 lipidation. phosphatidylethanolamine 68-92 autophagy related 3 Homo sapiens 29-33 19285500-0 2009 The amino-terminal region of Atg3 is essential for association with phosphatidylethanolamine in Atg8 lipidation. phosphatidylethanolamine 68-92 GABA type A receptor associated protein like 1 Homo sapiens 96-100 19285500-3 2009 Autophagosome formation requires the conjugation of Atg8, a ubiquitin-like protein, to phosphatidylethanolamine (PE). phosphatidylethanolamine 87-111 GABA type A receptor associated protein like 1 Homo sapiens 52-56 19285500-3 2009 Autophagosome formation requires the conjugation of Atg8, a ubiquitin-like protein, to phosphatidylethanolamine (PE). phosphatidylethanolamine 113-115 GABA type A receptor associated protein like 1 Homo sapiens 52-56 19014349-1 2009 PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells. phosphatidylethanolamine 201-203 phosphatidylserine synthase 1 Homo sapiens 97-101 19200880-5 2009 Thus, the autophagic activity can be largely determined by GFP-LC3/LC3, predominantly associated with autophagosomes (when LC3 is conjugated to phosphatidylethanolamine), both biochemically and microscopically. phosphatidylethanolamine 144-168 microtubule associated protein 1 light chain 3 alpha Homo sapiens 59-70 19103740-1 2009 Raf kinase inhibitory protein (RKIP/PEBP1), a member of the phosphatidylethanolamine binding protein family that possesses a conserved ligand-binding pocket, negatively regulates the mammalian mitogen-activated protein kinase (MAPK) signaling cascade. phosphatidylethanolamine 60-84 phosphatidylethanolamine binding protein 1 Homo sapiens 0-29 19103740-1 2009 Raf kinase inhibitory protein (RKIP/PEBP1), a member of the phosphatidylethanolamine binding protein family that possesses a conserved ligand-binding pocket, negatively regulates the mammalian mitogen-activated protein kinase (MAPK) signaling cascade. phosphatidylethanolamine 60-84 phosphatidylethanolamine binding protein 1 Homo sapiens 31-35 19103740-1 2009 Raf kinase inhibitory protein (RKIP/PEBP1), a member of the phosphatidylethanolamine binding protein family that possesses a conserved ligand-binding pocket, negatively regulates the mammalian mitogen-activated protein kinase (MAPK) signaling cascade. phosphatidylethanolamine 60-84 phosphatidylethanolamine binding protein 1 Homo sapiens 36-41 19221197-5 2009 We show that Ups1 and Gep1 regulate the levels of cardiolipin and phosphatidylethanolamine in mitochondria in a lipid-specific but coordinated manner. phosphatidylethanolamine 66-90 Ups1p Saccharomyces cerevisiae S288C 13-17 19221197-5 2009 We show that Ups1 and Gep1 regulate the levels of cardiolipin and phosphatidylethanolamine in mitochondria in a lipid-specific but coordinated manner. phosphatidylethanolamine 66-90 Ups2p Saccharomyces cerevisiae S288C 22-26 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 steroidogenic acute regulatory protein Homo sapiens 112-118 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 StAR related lipid transfer domain containing 3 Homo sapiens 119-127 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 StAR related lipid transfer domain containing 5 Homo sapiens 129-135 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 phosphatidylcholine transfer protein Homo sapiens 137-143 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 StAR related lipid transfer domain containing 10 Homo sapiens 144-151 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 StAR related lipid transfer domain containing 10 Homo sapiens 153-160 19239851-6 2009 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3-6, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 ceramide transporter 1 Homo sapiens 165-172 18988890-9 2009 Moreover, EL expression was positively associated with lysophosphatidylcholine production and inversely with phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin levels. phosphatidylethanolamine 130-154 lipase G, endothelial type Homo sapiens 10-12 19200880-5 2009 Thus, the autophagic activity can be largely determined by GFP-LC3/LC3, predominantly associated with autophagosomes (when LC3 is conjugated to phosphatidylethanolamine), both biochemically and microscopically. phosphatidylethanolamine 144-168 microtubule associated protein 1 light chain 3 alpha Homo sapiens 63-66 18790996-3 2009 The formation and trafficking of autophagic vesicles are directed in part by associated conjugation cascades that couple the AUTOPHAGY-RELATED8 (ATG8) and ATG12 proteins to their respective targets, phosphatidylethanolamine and the ATG5 protein. phosphatidylethanolamine 199-223 Ubiquitin-like protein ATG12 Zea mays 155-160 19014349-1 2009 PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells. phosphatidylethanolamine 201-203 phosphatidylserine synthase 1 Homo sapiens 103-116 19014349-1 2009 PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells. phosphatidylethanolamine 201-203 phosphatidylserine synthase 2 Homo sapiens 122-126 19014349-1 2009 PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells. phosphatidylethanolamine 205-229 phosphatidylserine synthase 1 Homo sapiens 97-101 19014349-1 2009 PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells. phosphatidylethanolamine 205-229 phosphatidylserine synthase 1 Homo sapiens 103-116 19014349-1 2009 PS (phosphatidylserine) in mammalian cells is synthesized by two distinct base-exchange enzymes, PSS1 (PS synthase 1) and PSS2, which are responsible for the conversion of PC (phosphatidylcholine) and PE (phosphatidylethanolamine) respectively into PS in intact cells. phosphatidylethanolamine 205-229 phosphatidylserine synthase 2 Homo sapiens 122-126 19014349-4 2009 The purified PSS2 was shown to catalyse the conversion of PE, but not PC, into PS, this being consistent with the substrate specificity observed in intact cells. phosphatidylethanolamine 58-60 phosphatidylserine synthase 2 Homo sapiens 13-17 19014349-5 2009 On the other hand, the purified PSS1 was shown to catalyse the conversion of both PC and PE into PS, although PSS1 in intact cells had been shown not to contribute to the conversion of PE into PS to a significant extent. phosphatidylethanolamine 89-91 phosphatidylserine synthase 1 Homo sapiens 32-36 18842588-1 2008 Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine to phosphatidylcholine (PC). phosphatidylethanolamine 93-117 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 18842588-1 2008 Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine to phosphatidylcholine (PC). phosphatidylethanolamine 93-117 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 18931395-6 2008 In strains in which DNF1 and DNF2 are both deleted, the flip of NBD-PS is increased approximately 2-fold over that of the isogenic parent strain, whereas the flip of NBD-labeled phosphatidylcholine and NBD-labeled phosphatidylethanolamine are reduced to approximately 20 and approximately 50%, respectively. phosphatidylethanolamine 214-238 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 20-24 18931395-7 2008 The mechanism responsible for NBD-PS flip is similar to that for NBD-labeled phosphatidylcholine and NBD-labeled phosphatidylethanolamine in its dependence on cellular ATP and the plasma membrane proton electrochemical gradient, as well as its regulation by the transcription factors Pdr1p and Pdr3p. phosphatidylethanolamine 113-137 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 284-289 18931395-7 2008 The mechanism responsible for NBD-PS flip is similar to that for NBD-labeled phosphatidylcholine and NBD-labeled phosphatidylethanolamine in its dependence on cellular ATP and the plasma membrane proton electrochemical gradient, as well as its regulation by the transcription factors Pdr1p and Pdr3p. phosphatidylethanolamine 113-137 drug-responsive transcription factor PDR3 Saccharomyces cerevisiae S288C 294-299 18629440-5 2008 hPLSCR1 showed higher rates of scrambling activity for phosphatidylethanolamine than phosphatidylcholine. phosphatidylethanolamine 55-79 phospholipid scramblase 1 Homo sapiens 0-7 18755794-8 2008 Expression analysis indicates that the absence of an apparent phenotype in the Eki2-deficient mice may be due to compensation by Eki2-family members or the activation of an alternative pathway to generate phosphatidylethanolamine. phosphatidylethanolamine 205-229 ethanolamine kinase 2 Mus musculus 79-83 18791037-2 2008 Phosphatidate phosphatase-1 (PAP1) enzymes have a key role in glycerolipid synthesis through the conversion of phosphatidate to diacylglycerol, the immediate precursor of triacylglycerol, phosphatidylcholine, and phosphatidylethanolamine. phosphatidylethanolamine 213-237 lipin 1 Homo sapiens 0-27 19017977-11 2008 LPLA(2)(-/-) alveolar macrophages are characterized by marked accumulation of phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 102-126 phospholipase A2, group XV Mus musculus 0-7 18791037-2 2008 Phosphatidate phosphatase-1 (PAP1) enzymes have a key role in glycerolipid synthesis through the conversion of phosphatidate to diacylglycerol, the immediate precursor of triacylglycerol, phosphatidylcholine, and phosphatidylethanolamine. phosphatidylethanolamine 213-237 lipin 1 Homo sapiens 29-33 18773301-6 2008 Lipid profile analysis further revealed that an acbp4 knockout mutant showed decreases in membrane lipids (digalactosyldiacylglycerol, monogalactosyldiacylglycerol, phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol) while acbp4-complemented lines attained levels similar to wild type, suggesting that ACBP4 plays a role in the biosynthesis of membrane lipids including galactolipids and phospholipids. phosphatidylethanolamine 186-210 acyl-CoA binding protein 4 Arabidopsis thaliana 48-53 19002082-1 2008 Phosphatidylcholine-specific phospholipase C (PC-PLC) catalyzes the hydrolysis of the ester linkage between glycerol and phosphate in phosphocholine (PC) and other phosphatides, such as sphingomylin (SM) and phosphatidylethanolamine (PE). phosphatidylethanolamine 208-232 heparan sulfate proteoglycan 2 Homo sapiens 49-52 18564061-6 2008 Furthermore, phosphatidylethanolamine glycation decreases by approximately 30% the stability of PMCA against thermal denaturation, suggesting that glycated aminophospholipids induce a structural rearrangement in the protein that makes it more sensitive to thermal unfolding. phosphatidylethanolamine 13-37 ATPase plasma membrane Ca2+ transporting 2 Homo sapiens 96-100 18849965-5 2008 Atg16L1-deficiency disrupts the recruitment of the Atg12-Atg5 conjugate to the isolation membrane, resulting in a loss of microtubule-associated protein 1 light chain 3 (LC3) conjugation to phosphatidylethanolamine. phosphatidylethanolamine 190-214 autophagy related 12 Mus musculus 51-56 19002082-1 2008 Phosphatidylcholine-specific phospholipase C (PC-PLC) catalyzes the hydrolysis of the ester linkage between glycerol and phosphate in phosphocholine (PC) and other phosphatides, such as sphingomylin (SM) and phosphatidylethanolamine (PE). phosphatidylethanolamine 234-236 heparan sulfate proteoglycan 2 Homo sapiens 49-52 18922107-1 2008 BACKGROUND: New investigational agents and chemotherapy regimens including cyclophosphamide + topotecan, temozolomide + irinotecan, and anti-IGF-1R antibodies in Ewing"s sarcoma (ES) and liposomal muramyltripeptide phosphatidylethanolamine (L-MTP-PE), aerosol therapy, and bone-specific agents in osteosarcoma (OS) may improve survival and/or quality of life on "continuation" therapy. phosphatidylethanolamine 215-239 insulin like growth factor 1 receptor Homo sapiens 141-147 18784080-4 2008 We report that inclusion of phosphatidylethanolamine into reconstituted SNARE vesicles enabled isolated C2B, but not C2A, to regulate Ca2+-triggered fusion. phosphatidylethanolamine 28-52 secretoglobin family 2B member 3, pseudogene Homo sapiens 104-107 18784080-6 2008 Phosphatidylethanolamine increased both the rate and efficiency of C2AB- and C2B-regulated fusion without affecting their abilities to bind membrane-embedded syntaxin-SNAP-25 (t-SNARE) complexes. phosphatidylethanolamine 0-24 secretoglobin family 2B member 3, pseudogene Homo sapiens 77-80 18768752-1 2008 In the process of autophagy, a ubiquitin-like molecule, LC3/Atg8, is conjugated to phosphatidylethanolamine (PE) and associates with forming autophagosomes. phosphatidylethanolamine 83-107 microtubule associated protein 1 light chain 3 alpha Homo sapiens 56-59 18768752-1 2008 In the process of autophagy, a ubiquitin-like molecule, LC3/Atg8, is conjugated to phosphatidylethanolamine (PE) and associates with forming autophagosomes. phosphatidylethanolamine 83-107 GABA type A receptor associated protein like 1 Homo sapiens 60-64 18768752-1 2008 In the process of autophagy, a ubiquitin-like molecule, LC3/Atg8, is conjugated to phosphatidylethanolamine (PE) and associates with forming autophagosomes. phosphatidylethanolamine 109-111 microtubule associated protein 1 light chain 3 alpha Homo sapiens 56-59 18768752-1 2008 In the process of autophagy, a ubiquitin-like molecule, LC3/Atg8, is conjugated to phosphatidylethanolamine (PE) and associates with forming autophagosomes. phosphatidylethanolamine 109-111 GABA type A receptor associated protein like 1 Homo sapiens 60-64 18690009-1 2008 Atg8 and its mammalian homolog LC3, ubiquitin-like proteins (Ubls) required for autophagosome formation, are remarkably unique in that their conjugation target is the lipid phosphatidylethanolamine (PE). phosphatidylethanolamine 173-197 GABA type A receptor associated protein like 1 Homo sapiens 0-4 18690009-1 2008 Atg8 and its mammalian homolog LC3, ubiquitin-like proteins (Ubls) required for autophagosome formation, are remarkably unique in that their conjugation target is the lipid phosphatidylethanolamine (PE). phosphatidylethanolamine 173-197 microtubule associated protein 1 light chain 3 alpha Homo sapiens 31-34 18690009-1 2008 Atg8 and its mammalian homolog LC3, ubiquitin-like proteins (Ubls) required for autophagosome formation, are remarkably unique in that their conjugation target is the lipid phosphatidylethanolamine (PE). phosphatidylethanolamine 199-201 GABA type A receptor associated protein like 1 Homo sapiens 0-4 18690009-1 2008 Atg8 and its mammalian homolog LC3, ubiquitin-like proteins (Ubls) required for autophagosome formation, are remarkably unique in that their conjugation target is the lipid phosphatidylethanolamine (PE). phosphatidylethanolamine 199-201 microtubule associated protein 1 light chain 3 alpha Homo sapiens 31-34 18690009-2 2008 Although PE was identified as the sole lipid conjugated with Atg8/LC3 in vivo, phosphatidylserine (PS) can be also a good substrate for its conjugation reaction in vitro. phosphatidylethanolamine 9-11 GABA type A receptor associated protein like 1 Homo sapiens 61-65 18690009-2 2008 Although PE was identified as the sole lipid conjugated with Atg8/LC3 in vivo, phosphatidylserine (PS) can be also a good substrate for its conjugation reaction in vitro. phosphatidylethanolamine 9-11 microtubule associated protein 1 light chain 3 alpha Homo sapiens 66-69 18704115-6 2008 Similarly, Atg7 and Atg3 are the respective E1-like and E2-like proteins that mediate the conjugation of Atg8 to phosphatidylethanolamine. phosphatidylethanolamine 113-137 autophagy related 7 Homo sapiens 11-15 18583706-2 2008 Phosphoethanolamine is the substrate of the regulatory enzyme CTP:phosphoethanolamine cytidylyltransferase (ECT) in the de novo biosynthesis of phosphatidylethanolamine (PE). phosphatidylethanolamine 144-168 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 62-106 18583706-2 2008 Phosphoethanolamine is the substrate of the regulatory enzyme CTP:phosphoethanolamine cytidylyltransferase (ECT) in the de novo biosynthesis of phosphatidylethanolamine (PE). phosphatidylethanolamine 170-172 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 62-106 18644857-4 2008 Pdr5 has been demonstrated to act as a phospholipid floppase catalyzing the net outward movement of phosphatidylethanolamine (PE). phosphatidylethanolamine 100-124 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 0-4 18644857-4 2008 Pdr5 has been demonstrated to act as a phospholipid floppase catalyzing the net outward movement of phosphatidylethanolamine (PE). phosphatidylethanolamine 126-128 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 0-4 18644857-5 2008 Since the mitochondrially localized Psd1 enzyme provides a major route of PE biosynthesis, we evaluated the potential linkage between Psd1 function and PDR5 regulation. phosphatidylethanolamine 74-76 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 36-40 18644857-8 2008 Surprisingly, expression of a catalytically inactive form of Psd1 still supported PDR5 transcriptional activation, suggesting that PE levels were not the signal triggering PDR5 induction. phosphatidylethanolamine 131-133 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 61-65 18704115-6 2008 Similarly, Atg7 and Atg3 are the respective E1-like and E2-like proteins that mediate the conjugation of Atg8 to phosphatidylethanolamine. phosphatidylethanolamine 113-137 autophagy related 3 Homo sapiens 20-24 18704115-6 2008 Similarly, Atg7 and Atg3 are the respective E1-like and E2-like proteins that mediate the conjugation of Atg8 to phosphatidylethanolamine. phosphatidylethanolamine 113-137 GABA type A receptor associated protein like 1 Homo sapiens 105-109 18599377-1 2008 The pem1/cho2 pem2/opi3 double mutant of Saccharomyces cerevisiae, which is auxotrophic for choline because of the deficiency in methylation activities of phosphatidylethanolamine, grew in the presence of 0.1 mM dioctanoyl-phosphatidylcholine (diC(8)PC). phosphatidylethanolamine 155-179 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 4-8 18591246-5 2008 TG accumulation is also observed in cho2 and opi3 mutants defective in methylation of phosphatidylethanolamine to PC, confirming that PC de novo synthesis and TG synthesis are metabolically coupled through the efficiency of the phospholipid methylation reaction. phosphatidylethanolamine 86-110 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 36-40 18591246-5 2008 TG accumulation is also observed in cho2 and opi3 mutants defective in methylation of phosphatidylethanolamine to PC, confirming that PC de novo synthesis and TG synthesis are metabolically coupled through the efficiency of the phospholipid methylation reaction. phosphatidylethanolamine 86-110 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 45-49 18560273-5 2008 The punctation was not due to nonspecific aggregation of LC3 since it depended on the amino acid residue Glycine120, which is specifically required for LC3 to conjugate to phosphatidylethanolamine (PE). phosphatidylethanolamine 172-196 microtubule associated protein 1 light chain 3 alpha Homo sapiens 152-155 18599377-1 2008 The pem1/cho2 pem2/opi3 double mutant of Saccharomyces cerevisiae, which is auxotrophic for choline because of the deficiency in methylation activities of phosphatidylethanolamine, grew in the presence of 0.1 mM dioctanoyl-phosphatidylcholine (diC(8)PC). phosphatidylethanolamine 155-179 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 9-13 18564386-7 2008 Expression in Escherichia coli revealed that NPC5 shows phospholipase C activity on phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 108-132 non-specific phospholipase C5 Arabidopsis thaliana 45-49 18599377-1 2008 The pem1/cho2 pem2/opi3 double mutant of Saccharomyces cerevisiae, which is auxotrophic for choline because of the deficiency in methylation activities of phosphatidylethanolamine, grew in the presence of 0.1 mM dioctanoyl-phosphatidylcholine (diC(8)PC). phosphatidylethanolamine 155-179 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 14-18 18599377-1 2008 The pem1/cho2 pem2/opi3 double mutant of Saccharomyces cerevisiae, which is auxotrophic for choline because of the deficiency in methylation activities of phosphatidylethanolamine, grew in the presence of 0.1 mM dioctanoyl-phosphatidylcholine (diC(8)PC). phosphatidylethanolamine 155-179 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 19-23 18782225-4 2008 In this study, we found that knockdown of another member of the MBOAT family in C. elegans, named mboa-6, reduced incorporation of exogenous PUFAs into phosphatidylcholine (PC), phosphatidylserine (PS) and phosphatidylethanolamine (PE) in C. elegans. phosphatidylethanolamine 206-230 Lysophospholipid acyltransferase 5 Caenorhabditis elegans 98-104 18670194-2 2008 Atg16L facilitates LC3/Atg8-conjugation to phosphatidylethanolamine by forming an oligomeric complex with Atg12-conjugated Atg5 and recruiting an LC3-Atg3 intermediate to elongating isolation membranes. phosphatidylethanolamine 43-67 microtubule associated protein 1 light chain 3 alpha Homo sapiens 19-22 18782225-4 2008 In this study, we found that knockdown of another member of the MBOAT family in C. elegans, named mboa-6, reduced incorporation of exogenous PUFAs into phosphatidylcholine (PC), phosphatidylserine (PS) and phosphatidylethanolamine (PE) in C. elegans. phosphatidylethanolamine 232-234 Lysophospholipid acyltransferase 5 Caenorhabditis elegans 98-104 18285826-2 2008 The ABCA4 protein is expressed in photoreceptors and possibly functions as a transporter for N-retinylidene-phosphatidylethanolamine (N-retinylidene-PE), the Schiff base adduct of all-trans-retinal with PE. phosphatidylethanolamine 108-132 ATP binding cassette subfamily A member 4 Homo sapiens 4-9 18555885-6 2008 (iii) VLPs assembled from wild-type ASV Gag exhibited highly efficient release from endosome-like membrane domains enriched in the tetraspanin protein CD63 or a fluorescent analogue of the phospholipid phosphatidylethanolamine. phosphatidylethanolamine 202-226 uncharacterized LOC107052719 Gallus gallus 40-43 18458083-5 2008 LPEAT2 is predominantly expressed in brain, coinciding with an enrichment of phosphatidylethanolamine in this tissue. phosphatidylethanolamine 77-101 lysophosphatidylcholine acyltransferase 4 Homo sapiens 0-6 18402553-8 2008 In contrast, PIS1-overexpressors contained significantly elevated levels of DAG and PtdEtn (phosphatidylethanolamine), an effect not observed in plants overexpressing PIS2. phosphatidylethanolamine 84-90 phosphatidylinositol synthase 1 Arabidopsis thaliana 13-17 18402553-8 2008 In contrast, PIS1-overexpressors contained significantly elevated levels of DAG and PtdEtn (phosphatidylethanolamine), an effect not observed in plants overexpressing PIS2. phosphatidylethanolamine 92-116 phosphatidylinositol synthase 1 Arabidopsis thaliana 13-17 18485513-2 2008 Lecithin:cholesterol acyltransferase (LCAT) increases HDL size by transferring 2-acyl groups from lecithin or phosphatidylethanolamine to unesterified cholesterol. phosphatidylethanolamine 110-134 lecithin-cholesterol acyltransferase Homo sapiens 0-36 18485513-2 2008 Lecithin:cholesterol acyltransferase (LCAT) increases HDL size by transferring 2-acyl groups from lecithin or phosphatidylethanolamine to unesterified cholesterol. phosphatidylethanolamine 110-134 lecithin-cholesterol acyltransferase Homo sapiens 38-42 18204094-8 2008 In addition, PE is made via the CDP-ethanolamine pathway, in which the final reaction occurs on the endoplasmic reticulum and nuclear envelope. phosphatidylethanolamine 13-15 cut like homeobox 1 Homo sapiens 32-35 18296489-8 2008 These properties place Cer-1-P in a class more akin to certain glycerophospholipids (phosphatidylethanolamine, phosphatidic acid) than to any other sphingolipid. phosphatidylethanolamine 85-109 cerberus 1, DAN family BMP antagonist Homo sapiens 23-28 18522808-8 2008 Compared to wildtype littermate controls, hearts from Gpat1(-/-)(-/-) mice contained a lower amount of 16:0 in phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine/phosphatidylinositol and significantly more C20:4n6. phosphatidylethanolamine 132-156 glycerol-3-phosphate acyltransferase, mitochondrial Mus musculus 54-59 18522808-9 2008 Phosphatidylcholine and phosphatidylethanolamine from Gpat1(-/-)(-/-) hearts also contained higher amounts of 18:0 and 18:1. phosphatidylethanolamine 24-48 glycerol-3-phosphate acyltransferase, mitochondrial Mus musculus 54-59 18064630-3 2008 We found a strong and specific correlation between the lower lateral mobility of phosphatidylcholine (PC) and higher lateral mobility of phosphatidylethanolamine (PE) when cells were expressing high levels of alpha5beta1 integrin and thus were adherent and motile on FN. phosphatidylethanolamine 137-161 fibronectin 1 Homo sapiens 267-269 18343815-3 2008 PSS1 exchanges serine for choline of phosphatidylcholine, whereas PSS2 exchanges ethanolamine of phosphatidylethanolamine for serine. phosphatidylethanolamine 97-121 phosphatidylserine synthase 2 Mus musculus 66-70 18343815-13 2008 We conclude that (i) elimination of either PSS1 or PSS2, but not both, is compatible with mouse viability, (ii) mice can tolerate as little as 10% of normal total serine-exchange activity, and (iii) mice survive with significantly reduced PS and phosphatidylethanolamine content. phosphatidylethanolamine 246-270 phosphatidylserine synthase 1 Mus musculus 43-47 18343815-13 2008 We conclude that (i) elimination of either PSS1 or PSS2, but not both, is compatible with mouse viability, (ii) mice can tolerate as little as 10% of normal total serine-exchange activity, and (iii) mice survive with significantly reduced PS and phosphatidylethanolamine content. phosphatidylethanolamine 246-270 phosphatidylserine synthase 2 Mus musculus 51-55 18259190-4 2008 When isolated mitochondria were incubated with phospholipase A2, which led to phosphatidylethanolamine and cardiolipin hydrolysis, tBid and Bax insertion were hindered. phosphatidylethanolamine 78-102 phospholipase A2 group IB Homo sapiens 47-63 18259190-5 2008 We thus studied in liposomes how phosphatidylethanolamine, cardiolipin, and its hydrolysis products affect Bax activation. phosphatidylethanolamine 33-57 BCL2 associated X, apoptosis regulator Homo sapiens 107-110 18259190-6 2008 Whereas phosphatidylethanolamine, a lipid with negative curvature, did not affect Bax insertion, it inhibited Bax oligomerization. phosphatidylethanolamine 8-32 BCL2 associated X, apoptosis regulator Homo sapiens 110-113 18670194-2 2008 Atg16L facilitates LC3/Atg8-conjugation to phosphatidylethanolamine by forming an oligomeric complex with Atg12-conjugated Atg5 and recruiting an LC3-Atg3 intermediate to elongating isolation membranes. phosphatidylethanolamine 43-67 GABA type A receptor associated protein like 1 Homo sapiens 23-27 18670194-2 2008 Atg16L facilitates LC3/Atg8-conjugation to phosphatidylethanolamine by forming an oligomeric complex with Atg12-conjugated Atg5 and recruiting an LC3-Atg3 intermediate to elongating isolation membranes. phosphatidylethanolamine 43-67 autophagy related 12 Homo sapiens 106-111 18670194-2 2008 Atg16L facilitates LC3/Atg8-conjugation to phosphatidylethanolamine by forming an oligomeric complex with Atg12-conjugated Atg5 and recruiting an LC3-Atg3 intermediate to elongating isolation membranes. phosphatidylethanolamine 43-67 autophagy related 5 Homo sapiens 123-127 18670194-2 2008 Atg16L facilitates LC3/Atg8-conjugation to phosphatidylethanolamine by forming an oligomeric complex with Atg12-conjugated Atg5 and recruiting an LC3-Atg3 intermediate to elongating isolation membranes. phosphatidylethanolamine 43-67 microtubule associated protein 1 light chain 3 alpha Homo sapiens 146-149 18670194-2 2008 Atg16L facilitates LC3/Atg8-conjugation to phosphatidylethanolamine by forming an oligomeric complex with Atg12-conjugated Atg5 and recruiting an LC3-Atg3 intermediate to elongating isolation membranes. phosphatidylethanolamine 43-67 autophagy related 3 Homo sapiens 150-154 18064630-3 2008 We found a strong and specific correlation between the lower lateral mobility of phosphatidylcholine (PC) and higher lateral mobility of phosphatidylethanolamine (PE) when cells were expressing high levels of alpha5beta1 integrin and thus were adherent and motile on FN. phosphatidylethanolamine 163-165 fibronectin 1 Homo sapiens 267-269 18064630-7 2008 We propose that these differences in distribution of PC and PE in different regions of cell membrane and their respective lateral mobility are observed due to the specific interaction of PC molecules with FN molecules in the ECM. phosphatidylethanolamine 60-62 fibronectin 1 Homo sapiens 205-207 24031205-6 2008 Labeling experiments with fluorescamine dye revealed that the percentage of the exposed aminophospholipid, phosphatidylethanolamine was highest in the resistant strains as compared to the susceptible strains, indicating a possible overexpression of CDR1 and CDR2 genes in resistant strains. phosphatidylethanolamine 107-131 cerebellar degeneration related protein 1 Homo sapiens 249-253 18321988-3 2008 LC3/Atg8 is conjugated to phosphatidylethanolamine and is associated with autophagosome formation, perhaps by enabling membrane elongation. phosphatidylethanolamine 26-50 microtubule associated protein 1 light chain 3 alpha Homo sapiens 0-3 18321988-3 2008 LC3/Atg8 is conjugated to phosphatidylethanolamine and is associated with autophagosome formation, perhaps by enabling membrane elongation. phosphatidylethanolamine 26-50 GABA type A receptor associated protein like 1 Homo sapiens 4-8 18451614-2 2008 Here, we used apoA-I and its model peptide, Ac-18A-NH(2), to investigate their interaction with mixed membranes of phosphatidylcholine (PC) with phosphatidylethanolamine (PE) or sphingomyelin (SM). phosphatidylethanolamine 145-169 apolipoprotein A1 Homo sapiens 14-20 24031205-6 2008 Labeling experiments with fluorescamine dye revealed that the percentage of the exposed aminophospholipid, phosphatidylethanolamine was highest in the resistant strains as compared to the susceptible strains, indicating a possible overexpression of CDR1 and CDR2 genes in resistant strains. phosphatidylethanolamine 107-131 cerebellar degeneration related protein 2 Homo sapiens 258-262 18199685-5 2008 Simultaneous disruption of FPK1 and its homolog FPK2 phenocopied the lem3Delta/dnf1Delta dnf2Delta mutants, exhibiting the impaired NBD-labeled phospholipid uptake, defects in the early endosome-to-TGN pathway in the absence of CDC50, and hyperpolarized bud growth after exposure of phosphatidylethanolamine at the bud tip. phosphatidylethanolamine 283-307 serine/threonine protein kinase FPK1 Saccharomyces cerevisiae S288C 27-31 18199685-5 2008 Simultaneous disruption of FPK1 and its homolog FPK2 phenocopied the lem3Delta/dnf1Delta dnf2Delta mutants, exhibiting the impaired NBD-labeled phospholipid uptake, defects in the early endosome-to-TGN pathway in the absence of CDC50, and hyperpolarized bud growth after exposure of phosphatidylethanolamine at the bud tip. phosphatidylethanolamine 283-307 putative serine/threonine protein kinase KIN82 Saccharomyces cerevisiae S288C 48-52 18094052-5 2008 In an independent set of experiments, we show that Fur4p targeting to the plasma membrane depends on phosphatidylethanolamine amounts and more specifically on the propensity of this phospholipid to form a hexagonal phase. phosphatidylethanolamine 101-125 uracil permease Saccharomyces cerevisiae S288C 51-56 17916326-5 2008 Absorption measurements indicate preferential oxidative interaction of HbE and alpha-globin subunit with unilamellar vesicles containing PE and PS compared to normal HbA. phosphatidylethanolamine 137-139 hemoglobin subunit epsilon 1 Homo sapiens 71-74 18056998-7 2008 Atypical PE and PS species were rapidly remodeled at both sn1 and sn2 position, yielding a molecular species profile similar to that the endogenous PE and PS. phosphatidylethanolamine 9-11 solute carrier family 38 member 3 Homo sapiens 58-61 18056998-7 2008 Atypical PE and PS species were rapidly remodeled at both sn1 and sn2 position, yielding a molecular species profile similar to that the endogenous PE and PS. phosphatidylethanolamine 9-11 solute carrier family 38 member 5 Homo sapiens 66-69 18039664-4 2008 AtATG12b was conjugated to AtATG5 in a manner dependent on AtATG7, AtATG10, and ATP, whereas AtATG8a was conjugated to phosphatidylethanolamine (PE) in a manner dependent on AtATG7, AtATG3, and ATP. phosphatidylethanolamine 119-143 Ubiquitin-like superfamily protein Arabidopsis thaliana 93-100 18039664-4 2008 AtATG12b was conjugated to AtATG5 in a manner dependent on AtATG7, AtATG10, and ATP, whereas AtATG8a was conjugated to phosphatidylethanolamine (PE) in a manner dependent on AtATG7, AtATG3, and ATP. phosphatidylethanolamine 145-147 Ubiquitin-like superfamily protein Arabidopsis thaliana 93-100 18000393-1 2008 A cytosolic form of LC3 is conjugated to phosphatidylethanolamine by Atg7, an E1-like enzyme, and Atg3, an E2-like enzyme, during autophagy. phosphatidylethanolamine 41-65 microtubule associated protein 1 light chain 3 alpha Homo sapiens 20-23 17951297-3 2008 Substitution of 20-60% phosphatidylethanolamine (DOPE) for phosphatidylcholine in the v-SNARE vesicle with either 0 or 20% DOPE included in the t-SNARE bilayer gives rise to hemifusion events. phosphatidylethanolamine 23-47 vesicle transport through interaction with t-SNAREs 1B Homo sapiens 86-93 17916326-8 2008 HbE was found to induce fusion of membrane vesicles containing cholesterol and PE when observed under electron microscope. phosphatidylethanolamine 79-81 hemoglobin subunit epsilon 1 Homo sapiens 0-3 18000393-1 2008 A cytosolic form of LC3 is conjugated to phosphatidylethanolamine by Atg7, an E1-like enzyme, and Atg3, an E2-like enzyme, during autophagy. phosphatidylethanolamine 41-65 autophagy related 7 Homo sapiens 69-73 18425443-3 2008 Concomitantly, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes. phosphatidylethanolamine 64-88 microtubule associated protein 1 light chain 3 alpha Homo sapiens 35-38 17923513-6 2008 Immunoblot analysis showed that the increase in phosphatidylethanolamine-conjugated membrane-associated Atg8 was also accompanied by the emergence of Atg8-associated structures during the proliferation and differentiation mentioned above. phosphatidylethanolamine 48-72 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 104-108 17923513-6 2008 Immunoblot analysis showed that the increase in phosphatidylethanolamine-conjugated membrane-associated Atg8 was also accompanied by the emergence of Atg8-associated structures during the proliferation and differentiation mentioned above. phosphatidylethanolamine 48-72 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 150-154 18425443-3 2008 Concomitantly, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes. phosphatidylethanolamine 64-88 microtubule associated protein 1 light chain 3 alpha Homo sapiens 40-45 18425443-3 2008 Concomitantly, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes. phosphatidylethanolamine 64-88 microtubule associated protein 1 light chain 3 alpha Homo sapiens 40-43 18425443-3 2008 Concomitantly, a cytosolic form of LC3 (LC3-I) is conjugated to phosphatidylethanolamine to form LC3-phosphatidylethanolamine conjugate (LC3-II), which is recruited to autophagosomal membranes. phosphatidylethanolamine 64-88 microtubule associated protein 1 light chain 3 alpha Homo sapiens 40-43 18425453-2 2008 To enhance MHC class II presentation of potential vaccine antigens, we have developed a method to target antigens for autophagic degradation via fusion to the Atg8/LC3 protein: Atg8/LC3 is specifically incorporated into autophagosomes via coupling to phosphatidylethanolamine, and subsequently degraded in MHC class II loading compartments (MIICs). phosphatidylethanolamine 251-275 GABA type A receptor associated protein like 1 Homo sapiens 159-163 18425453-2 2008 To enhance MHC class II presentation of potential vaccine antigens, we have developed a method to target antigens for autophagic degradation via fusion to the Atg8/LC3 protein: Atg8/LC3 is specifically incorporated into autophagosomes via coupling to phosphatidylethanolamine, and subsequently degraded in MHC class II loading compartments (MIICs). phosphatidylethanolamine 251-275 microtubule associated protein 1 light chain 3 alpha Homo sapiens 164-167 18425453-2 2008 To enhance MHC class II presentation of potential vaccine antigens, we have developed a method to target antigens for autophagic degradation via fusion to the Atg8/LC3 protein: Atg8/LC3 is specifically incorporated into autophagosomes via coupling to phosphatidylethanolamine, and subsequently degraded in MHC class II loading compartments (MIICs). phosphatidylethanolamine 251-275 GABA type A receptor associated protein like 1 Homo sapiens 177-181 18425453-2 2008 To enhance MHC class II presentation of potential vaccine antigens, we have developed a method to target antigens for autophagic degradation via fusion to the Atg8/LC3 protein: Atg8/LC3 is specifically incorporated into autophagosomes via coupling to phosphatidylethanolamine, and subsequently degraded in MHC class II loading compartments (MIICs). phosphatidylethanolamine 251-275 microtubule associated protein 1 light chain 3 alpha Homo sapiens 182-185 17655883-0 2008 The stimulatory effect of phosphatidylethanolamine on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD). phosphatidylethanolamine 26-50 N-acyl phosphatidylethanolamine phospholipase D Rattus norvegicus 54-112 17655883-0 2008 The stimulatory effect of phosphatidylethanolamine on N-acylphosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD). phosphatidylethanolamine 26-50 N-acyl phosphatidylethanolamine phospholipase D Rattus norvegicus 114-122 17655883-6 2008 When it was examined if the membrane fractions can be replaced with various pure phospholipids, phosphatidylethanolamine activated NAPE-PLD up to 3.3 fold, which was followed by decrease in the stimulatory effects of Ca(2+) and several other divalent cations. phosphatidylethanolamine 96-120 N-acyl phosphatidylethanolamine phospholipase D Rattus norvegicus 131-139 17655883-7 2008 These results suggest that membrane components including phosphatidylethanolamine keep the membrane-associated form of NAPE-PLD constitutively active. phosphatidylethanolamine 57-81 N-acyl phosphatidylethanolamine phospholipase D Rattus norvegicus 119-127 22820672-1 2008 Metabolic pulse-chase experiments demonstrated that 25-hydroxycholesterol (25-OH), the endogenous activator of the liver X receptor (LXR), significantly reduced the biosynthesis of phosphatidylethanolamine via CDP-ethanolamine (Kennedy) pathway at the step catalyzed by CTP: phosphoethanolamine cytidylyltransferase (Pcyt2). phosphatidylethanolamine 181-205 nuclear receptor subfamily 1, group H, member 3 Mus musculus 115-131 22820672-1 2008 Metabolic pulse-chase experiments demonstrated that 25-hydroxycholesterol (25-OH), the endogenous activator of the liver X receptor (LXR), significantly reduced the biosynthesis of phosphatidylethanolamine via CDP-ethanolamine (Kennedy) pathway at the step catalyzed by CTP: phosphoethanolamine cytidylyltransferase (Pcyt2). phosphatidylethanolamine 181-205 nuclear receptor subfamily 1, group H, member 3 Mus musculus 133-136 22820672-1 2008 Metabolic pulse-chase experiments demonstrated that 25-hydroxycholesterol (25-OH), the endogenous activator of the liver X receptor (LXR), significantly reduced the biosynthesis of phosphatidylethanolamine via CDP-ethanolamine (Kennedy) pathway at the step catalyzed by CTP: phosphoethanolamine cytidylyltransferase (Pcyt2). phosphatidylethanolamine 181-205 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 270-315 22820672-1 2008 Metabolic pulse-chase experiments demonstrated that 25-hydroxycholesterol (25-OH), the endogenous activator of the liver X receptor (LXR), significantly reduced the biosynthesis of phosphatidylethanolamine via CDP-ethanolamine (Kennedy) pathway at the step catalyzed by CTP: phosphoethanolamine cytidylyltransferase (Pcyt2). phosphatidylethanolamine 181-205 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 317-322 17889282-2 2008 TF coagulant activity is critically dependent on the presence of aminophospholipids, such as phosphatidylserine (PS) and phosphatidylethanolamine (PE), but it is unknown whether or not TF-exposing EMP are enriched in such aminophospholipids. phosphatidylethanolamine 121-145 coagulation factor III, tissue factor Homo sapiens 0-2 18088010-6 2007 Labeling experiments with fluorescamine dye revealed that the percentage of phosphatidylethanolamine exposed to the membrane"s outer leaflet was higher in the resistant strains as compared to the sensitive strains, indicating increased floppase activity of the two major ABC drug efflux pumps, CDR1 and CDR2 possibly due to their overexpression in resistant strains. phosphatidylethanolamine 76-100 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 271-274 18088010-6 2007 Labeling experiments with fluorescamine dye revealed that the percentage of phosphatidylethanolamine exposed to the membrane"s outer leaflet was higher in the resistant strains as compared to the sensitive strains, indicating increased floppase activity of the two major ABC drug efflux pumps, CDR1 and CDR2 possibly due to their overexpression in resistant strains. phosphatidylethanolamine 76-100 cerebellar degeneration related protein 1 Homo sapiens 294-298 18088010-6 2007 Labeling experiments with fluorescamine dye revealed that the percentage of phosphatidylethanolamine exposed to the membrane"s outer leaflet was higher in the resistant strains as compared to the sensitive strains, indicating increased floppase activity of the two major ABC drug efflux pumps, CDR1 and CDR2 possibly due to their overexpression in resistant strains. phosphatidylethanolamine 76-100 cerebellar degeneration related protein 2 Homo sapiens 303-307 17986448-6 2007 The Atg12-Atg5 conjugate promotes the transfer of Atg8 from Atg3 to the substrate, phosphatidylethanolamine (PE), by stimulating the activity of Atg3. phosphatidylethanolamine 83-107 autophagy related 12 Homo sapiens 4-9 17986448-6 2007 The Atg12-Atg5 conjugate promotes the transfer of Atg8 from Atg3 to the substrate, phosphatidylethanolamine (PE), by stimulating the activity of Atg3. phosphatidylethanolamine 83-107 autophagy related 5 Homo sapiens 10-14 17986448-6 2007 The Atg12-Atg5 conjugate promotes the transfer of Atg8 from Atg3 to the substrate, phosphatidylethanolamine (PE), by stimulating the activity of Atg3. phosphatidylethanolamine 83-107 GABA type A receptor associated protein like 1 Homo sapiens 50-54 17986448-6 2007 The Atg12-Atg5 conjugate promotes the transfer of Atg8 from Atg3 to the substrate, phosphatidylethanolamine (PE), by stimulating the activity of Atg3. phosphatidylethanolamine 83-107 autophagy related 3 Homo sapiens 60-64 17986448-6 2007 The Atg12-Atg5 conjugate promotes the transfer of Atg8 from Atg3 to the substrate, phosphatidylethanolamine (PE), by stimulating the activity of Atg3. phosphatidylethanolamine 83-107 autophagy related 3 Homo sapiens 145-149 17986448-6 2007 The Atg12-Atg5 conjugate promotes the transfer of Atg8 from Atg3 to the substrate, phosphatidylethanolamine (PE), by stimulating the activity of Atg3. phosphatidylethanolamine 109-111 autophagy related 12 Homo sapiens 4-9 17986448-6 2007 The Atg12-Atg5 conjugate promotes the transfer of Atg8 from Atg3 to the substrate, phosphatidylethanolamine (PE), by stimulating the activity of Atg3. phosphatidylethanolamine 109-111 autophagy related 5 Homo sapiens 10-14 17986448-6 2007 The Atg12-Atg5 conjugate promotes the transfer of Atg8 from Atg3 to the substrate, phosphatidylethanolamine (PE), by stimulating the activity of Atg3. phosphatidylethanolamine 109-111 GABA type A receptor associated protein like 1 Homo sapiens 50-54 17986448-6 2007 The Atg12-Atg5 conjugate promotes the transfer of Atg8 from Atg3 to the substrate, phosphatidylethanolamine (PE), by stimulating the activity of Atg3. phosphatidylethanolamine 109-111 autophagy related 3 Homo sapiens 60-64 17986448-6 2007 The Atg12-Atg5 conjugate promotes the transfer of Atg8 from Atg3 to the substrate, phosphatidylethanolamine (PE), by stimulating the activity of Atg3. phosphatidylethanolamine 109-111 autophagy related 3 Homo sapiens 145-149 17986448-7 2007 We also show that the Atg12-Atg5 conjugate interacts with both Atg3 and PE-containing liposomes. phosphatidylethanolamine 72-74 autophagy related 12 Homo sapiens 22-27 17986448-7 2007 We also show that the Atg12-Atg5 conjugate interacts with both Atg3 and PE-containing liposomes. phosphatidylethanolamine 72-74 autophagy related 5 Homo sapiens 28-32 18048333-4 2007 In eyecups of Abcr(-/-) mice, a model of recessive Stargardt macular degeneration, all-trans-retinal dimer-phosphatidylethanolamine was increased relative to wild type and was more abundant than A2E. phosphatidylethanolamine 107-131 ATP-binding cassette, sub-family A (ABC1), member 4 Mus musculus 14-18 17889282-2 2008 TF coagulant activity is critically dependent on the presence of aminophospholipids, such as phosphatidylserine (PS) and phosphatidylethanolamine (PE), but it is unknown whether or not TF-exposing EMP are enriched in such aminophospholipids. phosphatidylethanolamine 147-149 coagulation factor III, tissue factor Homo sapiens 0-2 17994272-5 2007 Mice deficient in ABCA4 accumulate phosphatidylethanolamine, all-trans retinal, and N-retinylidene-phosphatidylethanolamine in photoreceptors and the diretinal pyridinium compound A2E in retinal pigment epithelial cells. phosphatidylethanolamine 35-59 ATP-binding cassette, sub-family A (ABC1), member 4 Mus musculus 18-23 17519227-5 2007 Using H (18)(2)O water, the compounds were shown to form by direct oxidation of endogenous phosphatidylethanolamine (PE) by 15-LOX, with PE being the preferred phospholipid pool containing 15-HETE. phosphatidylethanolamine 91-115 arachidonate 15-lipoxygenase Homo sapiens 127-130 17976194-0 2007 The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p. phosphatidylethanolamine 4-28 membrane insertase OXA1 Saccharomyces cerevisiae S288C 101-106 17976194-0 2007 The phosphatidylethanolamine level of yeast mitochondria is affected by the mitochondrial components Oxa1p and Yme1p. phosphatidylethanolamine 4-28 i-AAA protease YME1 Saccharomyces cerevisiae S288C 111-116 17976194-1 2007 The majority of phosphatidylethanolamine, an essential component of yeast mitochondria, is synthesized by phosphatidylserine decarboxylase 1 (Psd1p), a component of the inner mitochondrial membrane. phosphatidylethanolamine 16-40 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 142-147 17976194-2 2007 Here, we report that deletion of OXA1 encoding an inner mitochondrial membrane protein translocase markedly affects the mitochondrial phosphatidylethanolamine level. phosphatidylethanolamine 134-158 membrane insertase OXA1 Saccharomyces cerevisiae S288C 33-37 17976194-7 2007 In summary, our results demonstrate a link between the mitochondrial protein import machinery, assembly and stability of Psd1p, and phosphatidylethanolamine homeostasis in yeast mitochondria. phosphatidylethanolamine 132-156 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 121-126 17885683-3 2007 Sphk-deficient female mice (Sphk1(-/-)Sphk2(+/-)) exhibited both an enormous accumulation of dihydrosphingosine and sphingosine and a reduction in phosphatidylethanolamine levels in pregnant uteri. phosphatidylethanolamine 147-171 sphingosine kinase 1 Mus musculus 28-33 16996649-5 2007 The activity of PEMT in the liver plays an important role in the methylation of phosphatidylethanolamine (PE) to phosphatidylcholine (PC) and the delivery of essential polyunsaturated fatty acids (PUFAs) to peripheral tissues. phosphatidylethanolamine 80-104 phosphatidylethanolamine N-methyltransferase Homo sapiens 16-20 18025309-0 2007 Phosphatidylethanolamine critically supports internalization of cell-penetrating protein C inhibitor. phosphatidylethanolamine 0-24 serpin family A member 5 Homo sapiens 81-100 18025309-3 2007 Cell membrane translocation of PCI necessarily requires phosphatidylethanolamine (PE). phosphatidylethanolamine 56-80 serpin family A member 5 Homo sapiens 31-34 18025309-3 2007 Cell membrane translocation of PCI necessarily requires phosphatidylethanolamine (PE). phosphatidylethanolamine 82-84 serpin family A member 5 Homo sapiens 31-34 18025309-8 2007 Our findings show that its specific shape enables cell surface PE to drive plasma membrane translocation of cell-penetrating PCI. phosphatidylethanolamine 63-65 serpin family A member 5 Homo sapiens 125-128 17981141-5 2007 In lem3Delta cells, the small GTPase Cdc42p remains polarized at the bud tip where phosphatidylethanolamine remains exposed on the outer leaflet. phosphatidylethanolamine 83-107 Rho family GTPase CDC42 Saccharomyces cerevisiae S288C 37-43 17981141-6 2007 Intriguingly, phosphatidylethanolamine and phosphatidylserine stimulate GTPase-activating protein (GAP) activity of Rga1p and Rga2p toward Cdc42p, whereas PI(4,5)P(2) inhibits it. phosphatidylethanolamine 14-38 GTPase-activating protein RGA1 Saccharomyces cerevisiae S288C 116-121 17981141-6 2007 Intriguingly, phosphatidylethanolamine and phosphatidylserine stimulate GTPase-activating protein (GAP) activity of Rga1p and Rga2p toward Cdc42p, whereas PI(4,5)P(2) inhibits it. phosphatidylethanolamine 14-38 GTPase-activating protein RGA2 Saccharomyces cerevisiae S288C 126-131 17981141-6 2007 Intriguingly, phosphatidylethanolamine and phosphatidylserine stimulate GTPase-activating protein (GAP) activity of Rga1p and Rga2p toward Cdc42p, whereas PI(4,5)P(2) inhibits it. phosphatidylethanolamine 14-38 Rho family GTPase CDC42 Saccharomyces cerevisiae S288C 139-145 17554109-1 2007 Raf kinase inhibitor protein-1 (RKIP-1) belongs to the phosphatidyl ethanolamine-binding family of proteins (PEBP), which are highly conserved throughout evolution and widely expressed in tissues of mammalian organisms. phosphatidylethanolamine 55-80 phosphatidylethanolamine binding protein 1 Mus musculus 32-36 17554109-1 2007 Raf kinase inhibitor protein-1 (RKIP-1) belongs to the phosphatidyl ethanolamine-binding family of proteins (PEBP), which are highly conserved throughout evolution and widely expressed in tissues of mammalian organisms. phosphatidylethanolamine 55-80 phosphatidylethanolamine binding protein 1 Homo sapiens 109-113 17673461-0 2007 The CDP-ethanolamine pathway and phosphatidylserine decarboxylation generate different phosphatidylethanolamine molecular species. phosphatidylethanolamine 87-111 cut like homeobox 1 Homo sapiens 4-7 17673461-1 2007 In mammalian cells, phosphatidylethanolamine (PtdEtn) is mainly synthesized via the CDP-ethanolamine (Kennedy) pathway and by decarboxylation of phosphatidylserine (PtdSer). phosphatidylethanolamine 20-44 cut like homeobox 1 Homo sapiens 84-87 17673461-1 2007 In mammalian cells, phosphatidylethanolamine (PtdEtn) is mainly synthesized via the CDP-ethanolamine (Kennedy) pathway and by decarboxylation of phosphatidylserine (PtdSer). phosphatidylethanolamine 46-52 cut like homeobox 1 Homo sapiens 84-87 17561512-1 2007 StarD10 is a dual specificity lipid transfer protein capable of shuttling phosphatidylcholine and phosphatidylethanolamine between membranes in vitro. phosphatidylethanolamine 98-122 StAR related lipid transfer domain containing 10 Homo sapiens 0-7 17478478-2 2007 PISD converts phosphatidylserine to phosphatidylethanolamine during lipid synthesis. phosphatidylethanolamine 36-60 phosphatidylserine decarboxylase Homo sapiens 0-4 17519227-5 2007 Using H (18)(2)O water, the compounds were shown to form by direct oxidation of endogenous phosphatidylethanolamine (PE) by 15-LOX, with PE being the preferred phospholipid pool containing 15-HETE. phosphatidylethanolamine 117-119 arachidonate 15-lipoxygenase Homo sapiens 127-130 17614848-1 2007 Phosphatidylcholine plays an important role for the structure and function of the cell membrane, and its synthesis from phosphatidylethanolamine is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 120-144 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 161-205 17632052-1 2007 Atg8 is a ubiquitin-like protein involved in autophagy in yeast that is targeted to membranes through conjugation to the lipid phosphatidylethanolamine (PE). phosphatidylethanolamine 127-151 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 0-4 17632052-1 2007 Atg8 is a ubiquitin-like protein involved in autophagy in yeast that is targeted to membranes through conjugation to the lipid phosphatidylethanolamine (PE). phosphatidylethanolamine 153-155 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 0-4 17632052-3 2007 (2007) show that Atg8 conjugated to PE mediates tethering between adjacent membranes and stimulates membrane hemifusion, an event that may mimic expansion of the autophagosomal membrane during autophagy. phosphatidylethanolamine 36-38 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 17-21 17632063-2 2007 Atg8 is a ubiquitin-like protein required for this process in Saccharomyces cerevisiae that can be conjugated to the lipid phosphatidylethanolamine by a ubiquitin-like system. phosphatidylethanolamine 123-147 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 0-4 17614848-1 2007 Phosphatidylcholine plays an important role for the structure and function of the cell membrane, and its synthesis from phosphatidylethanolamine is catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 120-144 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 207-211 17377489-6 2007 A fourth highly enriched autophagosomal protein, phosphatidylethanolamine binding protein, is particularly interesting considering that the autophagic marker protein, LC3/ Atg8, is linked to autophagosomal membranes through its covalent conjugation with phosphatidylethanolamine (as the form LC3-II). phosphatidylethanolamine 49-73 annexin A3 Rattus norvegicus 167-170 17377489-6 2007 A fourth highly enriched autophagosomal protein, phosphatidylethanolamine binding protein, is particularly interesting considering that the autophagic marker protein, LC3/ Atg8, is linked to autophagosomal membranes through its covalent conjugation with phosphatidylethanolamine (as the form LC3-II). phosphatidylethanolamine 49-73 annexin A3 Rattus norvegicus 292-295 17387262-3 2007 Upon induction of autophagy, LC3 is conjugated to phosphatidylethanolamine and targeted to autophagic membranes. phosphatidylethanolamine 50-74 microtubule associated protein 1 light chain 3 alpha Homo sapiens 29-32 17258706-4 2007 Mitochondrial phosphatidylethanolamine and phosphatidylcholine from Gpat1-/- liver contained 21% and 67% more arachidonate, respectively, than wildtype controls, and higher amounts of 4-hydroxynonenal, a product of arachidonate peroxidation. phosphatidylethanolamine 14-38 glycerol-3-phosphate acyltransferase, mitochondrial Mus musculus 68-73 17513168-2 2007 Animals obtain choline from both the diet and via endogenous biosynthesis that involves the conversion of phosphatidylethanolamine into PC by phosphatidylethanolamine N-methyltransferase (PEMT), followed by PC catabolism. phosphatidylethanolamine 106-130 phosphatidylethanolamine N-methyltransferase Mus musculus 142-186 17513168-2 2007 Animals obtain choline from both the diet and via endogenous biosynthesis that involves the conversion of phosphatidylethanolamine into PC by phosphatidylethanolamine N-methyltransferase (PEMT), followed by PC catabolism. phosphatidylethanolamine 106-130 phosphatidylethanolamine N-methyltransferase Mus musculus 188-192 17449644-0 2007 Deficiency in phosphatidylserine decarboxylase activity in the psd1 psd2 psd3 triple mutant of Arabidopsis affects phosphatidylethanolamine accumulation in mitochondria. phosphatidylethanolamine 115-139 phosphatidylserine decarboxylase 1 Arabidopsis thaliana 63-72 17218614-10 2007 LPC induced up-regulation of the active conformation of CD11b, which was blocked by preincubation with phosphatidylethanolamine. phosphatidylethanolamine 103-127 integrin subunit alpha M Homo sapiens 56-61 17283071-2 2007 Choline can also be generated by the catabolism of phosphatidylcholine synthesized in the liver by the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 118-142 phosphatidylethanolamine N-methyltransferase Mus musculus 146-190 17283071-2 2007 Choline can also be generated by the catabolism of phosphatidylcholine synthesized in the liver by the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 118-142 phosphatidylethanolamine N-methyltransferase Mus musculus 192-196 16807089-4 2007 Alterations in phosphatidylinositol and phosphatidylethanolamine can be ascribed to an increase in PIS1-encoded phosphatidylinositol synthase activity and to decreases in the activities of CDP-diacylglycerol pathway enzymes including the CHO1-encoded phosphatidylserine synthase, respectively. phosphatidylethanolamine 40-64 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 99-103 16807089-4 2007 Alterations in phosphatidylinositol and phosphatidylethanolamine can be ascribed to an increase in PIS1-encoded phosphatidylinositol synthase activity and to decreases in the activities of CDP-diacylglycerol pathway enzymes including the CHO1-encoded phosphatidylserine synthase, respectively. phosphatidylethanolamine 40-64 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 238-242 17160562-1 2007 The FT/TFL1 gene family encodes proteins with similarity to phosphatidylethanolamine binding proteins which function as flowering promoters and repressors. phosphatidylethanolamine 60-84 PEBP (phosphatidylethanolamine-binding protein) family protein Arabidopsis thaliana 7-11 17626977-1 2007 A novel lysosomal phospholipase A(2) (LPLA2) with specificity toward phosphatidylethanolamine and phosphatidylcholine was previously purified and cloned. phosphatidylethanolamine 69-93 phospholipase A2 group XV Homo sapiens 8-36 17626977-1 2007 A novel lysosomal phospholipase A(2) (LPLA2) with specificity toward phosphatidylethanolamine and phosphatidylcholine was previously purified and cloned. phosphatidylethanolamine 69-93 phospholipase A2 group XV Homo sapiens 38-43 17332248-1 2007 Protein C inhibitor (PCI) is a serpin with affinity for heparin and phosphatidylethanolamine (PE). phosphatidylethanolamine 68-92 serpin family A member 5 Homo sapiens 0-19 17332248-1 2007 Protein C inhibitor (PCI) is a serpin with affinity for heparin and phosphatidylethanolamine (PE). phosphatidylethanolamine 94-96 serpin family A member 5 Homo sapiens 0-19 17332248-9 2007 PCI and annexin V were found to be endogenously colocalized in atherosclerotic plaques, supporting the hypothesis that exposure of oxidized PE and/or PS may be important for the local regulation of PCI activity in vivo. phosphatidylethanolamine 140-142 annexin A5 Homo sapiens 8-17 17449644-0 2007 Deficiency in phosphatidylserine decarboxylase activity in the psd1 psd2 psd3 triple mutant of Arabidopsis affects phosphatidylethanolamine accumulation in mitochondria. phosphatidylethanolamine 115-139 phosphatidylserine decarboxylase 3 Arabidopsis thaliana 73-77 17449644-7 2007 While the phospholipid composition in whole leaves was unchanged, the PE content in isolated mitochondria of psd1 psd2 psd3 was decreased. phosphatidylethanolamine 70-72 phosphatidylserine decarboxylase 2 Arabidopsis thaliana 109-118 17449644-7 2007 While the phospholipid composition in whole leaves was unchanged, the PE content in isolated mitochondria of psd1 psd2 psd3 was decreased. phosphatidylethanolamine 70-72 phosphatidylserine decarboxylase 3 Arabidopsis thaliana 119-123 17391797-2 2007 A functional polymorphism Val175Met was reported in phosphatidylethanolamine N-methyltransferase (PEMT) that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 52-76 phosphatidylethanolamine N-methyltransferase Homo sapiens 98-102 17227760-1 2007 Atg3 is an E2-like enzyme that catalyzes the conjugation of Atg8 and phosphatidylethanolamine (PE). phosphatidylethanolamine 69-93 Atg3p Saccharomyces cerevisiae S288C 0-4 17227760-1 2007 Atg3 is an E2-like enzyme that catalyzes the conjugation of Atg8 and phosphatidylethanolamine (PE). phosphatidylethanolamine 95-97 Atg3p Saccharomyces cerevisiae S288C 0-4 17312007-4 2007 MTP and MTPv1 efficiently transferred phosphatidylethanolamine to CD1d in vitro. phosphatidylethanolamine 38-62 microsomal triglyceride transfer protein Mus musculus 0-3 17312007-4 2007 MTP and MTPv1 efficiently transferred phosphatidylethanolamine to CD1d in vitro. phosphatidylethanolamine 38-62 CD1d1 antigen Mus musculus 66-70 17132865-1 2007 CDP-ethanolamine:diacylglycerol ethanolaminephosphotransferase (EPT) catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine (PE). phosphatidylethanolamine 166-190 cut like homeobox 1 Homo sapiens 0-3 17132865-1 2007 CDP-ethanolamine:diacylglycerol ethanolaminephosphotransferase (EPT) catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine (PE). phosphatidylethanolamine 166-190 cut like homeobox 1 Homo sapiens 120-123 17132865-1 2007 CDP-ethanolamine:diacylglycerol ethanolaminephosphotransferase (EPT) catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine (PE). phosphatidylethanolamine 192-194 cut like homeobox 1 Homo sapiens 0-3 17132865-1 2007 CDP-ethanolamine:diacylglycerol ethanolaminephosphotransferase (EPT) catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine (PE). phosphatidylethanolamine 192-194 cut like homeobox 1 Homo sapiens 120-123 17132865-2 2007 To date, the dual specificity of choline/ethanolaminephosphotransferase (CEPT) has been recognized as the total activity responsible for the synthesis of PE via the CDP-ethanolamine pathway in human. phosphatidylethanolamine 154-156 cut like homeobox 1 Homo sapiens 165-168 17132865-5 2007 Bacterial expression of the cDNA in Escherichia coli demonstrated that the product specifically used CDP-ethanolamine as the phosphobase donor to produce PE with the activation by both Mn(2+) and Mg(2+). phosphatidylethanolamine 154-156 cut like homeobox 1 Homo sapiens 101-104 17158102-5 2007 Upon overexpression in COS-7 cells, one protein, named rat LRAT-like protein (RLP)-1, catalyzed transfer of a radioactive acyl group from phosphatidylcholine (PC) to PE, resulting in the formation of radioactive NAPE. phosphatidylethanolamine 166-168 lecithin retinol acyltransferase Rattus norvegicus 59-63 17158102-7 2007 Moreover, RLP-1 did not show selectivity with respect to the sn-1 and sn-2 positions of PC as an acyl donor and therefore could generate N-arachidonoyl-PE (anandamide precursor) from 2-arachidonoyl-PC and PE. phosphatidylethanolamine 152-154 phospholipase A and acyltransferase 5 Homo sapiens 10-15 17277449-1 2007 The reversible modification of Atg8 with phosphatidylethanolamine (PE) is crucial for autophagy, the bulk degradation process of cytoplasmic components by the vacuolar/lysosomal system. phosphatidylethanolamine 41-65 GABA type A receptor associated protein like 1 Homo sapiens 31-35 17277449-1 2007 The reversible modification of Atg8 with phosphatidylethanolamine (PE) is crucial for autophagy, the bulk degradation process of cytoplasmic components by the vacuolar/lysosomal system. phosphatidylethanolamine 67-69 GABA type A receptor associated protein like 1 Homo sapiens 31-35 16963840-1 2007 The ubiquitin-like conjugation reactions, ATG8/microtubule-associated protein 1 light chain 3/MAP1LC3 (LC3) to phosphatidylethanolamine (PE) and ATG12 to ATG5, are biochemical hallmarks for autophagy, a cellular process that degrades bulk cellular proteins and organelles. phosphatidylethanolamine 111-135 GABA type A receptor associated protein like 1 Homo sapiens 42-46 16963840-1 2007 The ubiquitin-like conjugation reactions, ATG8/microtubule-associated protein 1 light chain 3/MAP1LC3 (LC3) to phosphatidylethanolamine (PE) and ATG12 to ATG5, are biochemical hallmarks for autophagy, a cellular process that degrades bulk cellular proteins and organelles. phosphatidylethanolamine 111-135 microtubule associated protein 1 light chain 3 alpha Homo sapiens 98-101 16963840-1 2007 The ubiquitin-like conjugation reactions, ATG8/microtubule-associated protein 1 light chain 3/MAP1LC3 (LC3) to phosphatidylethanolamine (PE) and ATG12 to ATG5, are biochemical hallmarks for autophagy, a cellular process that degrades bulk cellular proteins and organelles. phosphatidylethanolamine 111-135 autophagy related 5 Homo sapiens 154-158 16963840-1 2007 The ubiquitin-like conjugation reactions, ATG8/microtubule-associated protein 1 light chain 3/MAP1LC3 (LC3) to phosphatidylethanolamine (PE) and ATG12 to ATG5, are biochemical hallmarks for autophagy, a cellular process that degrades bulk cellular proteins and organelles. phosphatidylethanolamine 137-139 GABA type A receptor associated protein like 1 Homo sapiens 42-46 16963840-1 2007 The ubiquitin-like conjugation reactions, ATG8/microtubule-associated protein 1 light chain 3/MAP1LC3 (LC3) to phosphatidylethanolamine (PE) and ATG12 to ATG5, are biochemical hallmarks for autophagy, a cellular process that degrades bulk cellular proteins and organelles. phosphatidylethanolamine 137-139 microtubule associated protein 1 light chain 3 alpha Homo sapiens 98-101 18176897-2 2007 Our data indicated that ASN (10 microM) inhibited [3H]AA incorporation into phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylserine (PS) together with phosphatidic acid (PA) by 13%, 27% and 38%, respectively. phosphatidylethanolamine 76-100 synuclein alpha Rattus norvegicus 24-27 17436686-3 2007 LPS-induced expression of E-selectin on human endothelial cells was inhibited by oxidized phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and phosphatidic acids. phosphatidylethanolamine 131-155 selectin E Homo sapiens 26-36 18176897-2 2007 Our data indicated that ASN (10 microM) inhibited [3H]AA incorporation into phosphatidylethanolamine (PE), phosphatidylcholine (PC) and phosphatidylserine (PS) together with phosphatidic acid (PA) by 13%, 27% and 38%, respectively. phosphatidylethanolamine 102-104 synuclein alpha Rattus norvegicus 24-27 16696965-6 2006 The destabilizing effect of Bet is more pronounced in membranes containing the nonbilayer galactolipid monogalactosyldiacylglycerol from plant chloroplasts than in membranes containing the nonbilayer phospholipid phosphatidylethanolamine. phosphatidylethanolamine 213-237 delta/notch like EGF repeat containing Homo sapiens 28-31 17169974-5 2007 NEX-1, -2, and -3 showed the binding activities to phosphatidylserine, phosphatidylinositol and phosphatidylethanolamine, but not to phosphatidylcholine. phosphatidylethanolamine 96-120 Annexin Caenorhabditis elegans 0-17 17142963-0 2006 Ochnaflavone, naturally occurring biflavonoid, inhibits phospholipase A2 dependent phosphatidylethanolamine degradation in a CCl4-induced rat liver microsome. phosphatidylethanolamine 83-107 phospholipase A2 group IB Rattus norvegicus 56-72 17142963-0 2006 Ochnaflavone, naturally occurring biflavonoid, inhibits phospholipase A2 dependent phosphatidylethanolamine degradation in a CCl4-induced rat liver microsome. phosphatidylethanolamine 83-107 C-C motif chemokine ligand 4 Rattus norvegicus 125-129 17142963-2 2006 When rat liver was incubated at 37 degrees C in the presence of CCl4, the level of phosphatidylethanolamine (PE) degradation increased markedly compared with the control. phosphatidylethanolamine 83-107 C-C motif chemokine ligand 4 Rattus norvegicus 64-68 17142963-2 2006 When rat liver was incubated at 37 degrees C in the presence of CCl4, the level of phosphatidylethanolamine (PE) degradation increased markedly compared with the control. phosphatidylethanolamine 109-111 C-C motif chemokine ligand 4 Rattus norvegicus 64-68 17028193-6 2006 With 100 or 750 mum [1-(14)C]oleate, Ad-Acsl1 increased oleate incorporation into diacylglycerol and phospholipids, particularly phosphatidylethanolamine and phosphatidylinositol, and decreased incorporation into cholesterol esters and secreted triacylglycerol. phosphatidylethanolamine 129-153 acyl-CoA synthetase long-chain family member 1 Rattus norvegicus 40-45 17005997-7 2006 TG-lipase was able to hydrolyze the major phospholipid components of the lipid droplets, phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 113-137 uncharacterized protein Drosophila melanogaster 0-9 17116711-1 2006 Phosphatidylcholine is an essential phospholipid that is synthesized by 2 different pathways, the CDP-choline pathway and the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 141-165 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 169-213 17116711-1 2006 Phosphatidylcholine is an essential phospholipid that is synthesized by 2 different pathways, the CDP-choline pathway and the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 141-165 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 215-219 17189343-7 2006 PECT activity was decreased by 47% in heterozygotic pect1-6 plants and by 80% in pect1-4/pect1-6 F1 plants, which also displayed a small but significant decrease of phosphatidylethanolamine and a reciprocal increase in phosphatidylcholine. phosphatidylethanolamine 165-189 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 81-86 17189343-7 2006 PECT activity was decreased by 47% in heterozygotic pect1-6 plants and by 80% in pect1-4/pect1-6 F1 plants, which also displayed a small but significant decrease of phosphatidylethanolamine and a reciprocal increase in phosphatidylcholine. phosphatidylethanolamine 165-189 phosphorylethanolamine cytidylyltransferase 1 Arabidopsis thaliana 81-86 17077504-6 2006 A combination of electrospray ionization mass-spectrometry and collision-induced decomposition mass-spectrometry methods indicate that recombinant Sfh1p loads predominantly with phosphatidylethanolamine. phosphatidylethanolamine 178-202 Sfh1p Saccharomyces cerevisiae S288C 147-152 17012800-1 2006 Atg3 is an E2-like enzyme that catalyzes the conjugation reaction between Atg8 and phosphatidylethanolamine (PE). phosphatidylethanolamine 83-107 Atg3p Saccharomyces cerevisiae S288C 0-4 17012800-1 2006 Atg3 is an E2-like enzyme that catalyzes the conjugation reaction between Atg8 and phosphatidylethanolamine (PE). phosphatidylethanolamine 83-107 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 74-78 17012800-1 2006 Atg3 is an E2-like enzyme that catalyzes the conjugation reaction between Atg8 and phosphatidylethanolamine (PE). phosphatidylethanolamine 109-111 Atg3p Saccharomyces cerevisiae S288C 0-4 17012800-1 2006 Atg3 is an E2-like enzyme that catalyzes the conjugation reaction between Atg8 and phosphatidylethanolamine (PE). phosphatidylethanolamine 109-111 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 74-78 16837646-11 2006 Thus, Lpla2 has broad positional specificity for the sn-1 and sn-2 acyl groups in phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 106-130 phospholipase A2, group XV Mus musculus 6-11 16861741-1 2006 Ethanolamine kinase catalyzes the first step in the CDP-ethanolamine pathway for the formation of the major membrane phospholipid phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 130-154 choline kinase beta Mus musculus 0-19 16861741-1 2006 Ethanolamine kinase catalyzes the first step in the CDP-ethanolamine pathway for the formation of the major membrane phospholipid phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 156-162 choline kinase beta Mus musculus 0-19 16861741-3 2006 Mice with an inactivated Etnk2 gene were derived, and its absence reduced the rate of PtdEtn synthesis from exogenous ethanolamine in hepatocytes. phosphatidylethanolamine 86-92 ethanolamine kinase 2 Mus musculus 25-30 16769123-1 2006 The pyrimidines cytidine (as CTP) and uridine (which is converted to UTP and then CTP) contribute to brain phosphatidylcholine and phosphatidylethanolamine synthesis via the Kennedy pathway. phosphatidylethanolamine 131-155 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 29-32 16769123-1 2006 The pyrimidines cytidine (as CTP) and uridine (which is converted to UTP and then CTP) contribute to brain phosphatidylcholine and phosphatidylethanolamine synthesis via the Kennedy pathway. phosphatidylethanolamine 131-155 phosphate cytidylyltransferase 1A, choline Rattus norvegicus 82-85 16766520-4 2006 In contrast to PC, CDP-ethanolamine-mediated phosphatidylethanolamine (PE) synthesis was inhibited by FC incubation. phosphatidylethanolamine 45-69 cut like homeobox 1 Homo sapiens 19-22 16766520-4 2006 In contrast to PC, CDP-ethanolamine-mediated phosphatidylethanolamine (PE) synthesis was inhibited by FC incubation. phosphatidylethanolamine 71-73 cut like homeobox 1 Homo sapiens 19-22 16696965-10 2006 The data offer an explanation, why Bet at high concentrations achieved during exogenous feeding of leaf tissues can be detrimental to cellular stability and survival under stress, while bacterial membranes that contain phosphatidylethanolamine instead of monogalactosyldiacylglycerol, or cyanobacteria that contain highly saturated monogalactosyldiacylglycerol are less susceptible. phosphatidylethanolamine 219-243 delta/notch like EGF repeat containing Homo sapiens 35-38 16756957-1 2006 Phosphatidylethanolamine N-methyltransferase (PEMT) is the enzyme that converts phosphatidylethanolamine (PE) into phosphatidylcholine. phosphatidylethanolamine 80-104 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 0-44 16880524-1 2006 A lysosomal phospholipase A2, LPLA2, was recently characterized and shown to have substrate specificity for phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 132-156 phospholipase A2, group XV Mus musculus 2-28 16880524-1 2006 A lysosomal phospholipase A2, LPLA2, was recently characterized and shown to have substrate specificity for phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 132-156 phospholipase A2, group XV Mus musculus 30-35 16880524-8 2006 A marked accumulation of phospholipids, in particular phosphatidylethanolamine and phosphatidylcholine, was found in the alveolar macrophages, the peritoneal macrophages, and the spleens of Lpla2-/- mice. phosphatidylethanolamine 54-78 phospholipase A2, group XV Mus musculus 190-195 16756957-1 2006 Phosphatidylethanolamine N-methyltransferase (PEMT) is the enzyme that converts phosphatidylethanolamine (PE) into phosphatidylcholine. phosphatidylethanolamine 80-104 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 46-50 16756957-1 2006 Phosphatidylethanolamine N-methyltransferase (PEMT) is the enzyme that converts phosphatidylethanolamine (PE) into phosphatidylcholine. phosphatidylethanolamine 46-48 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 0-44 16679290-2 2006 In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 73-75 phosphatidylethanolamine N-methyltransferase Mus musculus 80-124 16680092-2 2006 This protein undergoes reversible conjugation to phosphatidylethanolamine through a multistep process in which cleavage of Atg8 by a specific protease is followed by ubiquitin-like conjugation processes. phosphatidylethanolamine 49-73 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 123-127 16679290-2 2006 In liver, PC is synthesized via the choline pathway or by methylation of PE via phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 73-75 phosphatidylethanolamine N-methyltransferase Mus musculus 126-130 16618126-12 2006 Weakly translocated lipids (PE, phosphatidylhydroxypropionate, and phosphatidylhomoserine) are also weak Atp8a1 activators. phosphatidylethanolamine 28-30 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 Mus musculus 105-111 16500904-7 2006 ABCA1 showed lower ATPase activity when reconstituted in liposomes containing phosphatidylserine, phosphatidylethanolamine, or phosphatidylglycerol and also showed weak specificity in acyl chain species. phosphatidylethanolamine 98-122 ATP binding cassette subfamily A member 1 Homo sapiens 0-5 16500904-7 2006 ABCA1 showed lower ATPase activity when reconstituted in liposomes containing phosphatidylserine, phosphatidylethanolamine, or phosphatidylglycerol and also showed weak specificity in acyl chain species. phosphatidylethanolamine 98-122 dynein axonemal heavy chain 8 Homo sapiens 19-25 16611377-8 2006 The phosphatidylcholine:phosphatidylethanolamine ratio in rat liver increased with rising dietary methionine concentration; the relative mRNA concentrations of phosphatidylethanolamine N-methyltransferase and cystathionine beta-synthase remained unaffected. phosphatidylethanolamine 24-48 cystathionine beta synthase Rattus norvegicus 209-236 16675349-0 2006 Recognition of pollen-derived phosphatidyl-ethanolamine by human CD1d-restricted gamma delta T cells. phosphatidylethanolamine 30-55 CD1d molecule Homo sapiens 65-69 16675349-6 2006 RESULTS: Cloned gammadelta T lymphocytes from subjects with allergy, but not normal controls, were found to recognize pollen-derived phosphatidyl-ethanolamine (PE) in a CD1d-restricted fashion. phosphatidylethanolamine 133-158 CD1d molecule Homo sapiens 169-173 16675349-6 2006 RESULTS: Cloned gammadelta T lymphocytes from subjects with allergy, but not normal controls, were found to recognize pollen-derived phosphatidyl-ethanolamine (PE) in a CD1d-restricted fashion. phosphatidylethanolamine 160-162 CD1d molecule Homo sapiens 169-173 16618126-6 2006 The purified Atp8a1 is inactive in detergent micelles or in micelles containing phosphatidylcholine, phosphatidic acid, or phosphatidylinositol, is minimally activated by phosphatidylglycerol or phosphatidylethanolamine (PE), and is maximally activated by PS. phosphatidylethanolamine 195-219 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 Mus musculus 13-19 16618126-6 2006 The purified Atp8a1 is inactive in detergent micelles or in micelles containing phosphatidylcholine, phosphatidic acid, or phosphatidylinositol, is minimally activated by phosphatidylglycerol or phosphatidylethanolamine (PE), and is maximally activated by PS. phosphatidylethanolamine 221-223 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 Mus musculus 13-19 16363994-9 2006 Overexpression of PIS1 did not correct the cellular fatty acid content; however, saturated fatty acids (C(16:0)) accumulated preferentially in phosphatidylinositol, and (wild-type)-like fatty acid composition in phosphatidylethanolamine was restored. phosphatidylethanolamine 212-236 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 18-22 16452632-4 2006 Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE. phosphatidylethanolamine 161-163 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 22-27 16452632-4 2006 Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE. phosphatidylethanolamine 161-163 aminophospholipid-translocating P4-type ATPase DNF2 Saccharomyces cerevisiae S288C 32-37 16452632-4 2006 Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE. phosphatidylethanolamine 268-270 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 22-27 16452632-4 2006 Removal of P4 ATPases Dnf1p and Dnf2p from budding yeast abolishes inward translocation of 6-[(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminocaproyl] (NBD)-labeled PS, PE, and phosphatidylcholine (PC) across the plasma membrane and causes cell surface exposure of endogenous PE. phosphatidylethanolamine 268-270 aminophospholipid-translocating P4-type ATPase DNF2 Saccharomyces cerevisiae S288C 32-37 15941609-0 2006 Decreased phosphatidylethanolamine binding protein expression correlates with Abeta accumulation in the Tg2576 mouse model of Alzheimer"s disease. phosphatidylethanolamine 10-34 amyloid beta (A4) precursor protein Mus musculus 78-83 16445995-0 2006 Interactions of chromogranin A-derived vasostatins and monolayers of phosphatidylserine, phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 113-137 chromogranin A Sus scrofa 16-30 16487257-6 2006 Moreover, CDS-1 sera reacted strongly with a lipid component co-migrating with phosphatidylethanolamine (PE) in high performance thin-layer chromatography (HPTLC)-immunostaining of HEp-2 cell total lipid extracts. phosphatidylethanolamine 79-103 CDP-diacylglycerol synthase 1 Homo sapiens 10-15 16487257-6 2006 Moreover, CDS-1 sera reacted strongly with a lipid component co-migrating with phosphatidylethanolamine (PE) in high performance thin-layer chromatography (HPTLC)-immunostaining of HEp-2 cell total lipid extracts. phosphatidylethanolamine 105-107 CDP-diacylglycerol synthase 1 Homo sapiens 10-15 16024567-3 2006 AA is released from phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by phospholipase A2 (PLA2), or from phosphatidylinositol (PI) by phospholipase C (PLC) pathway. phosphatidylethanolamine 75-77 phospholipase A2 Oryctolagus cuniculus 82-98 16303767-0 2006 Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. phosphatidylethanolamine 34-58 GABA type A receptor associated protein like 2 Homo sapiens 98-102 16303767-0 2006 Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. phosphatidylethanolamine 34-58 microtubule associated protein 1 light chain 3 alpha Homo sapiens 114-117 16303767-0 2006 Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. phosphatidylethanolamine 34-58 GABA type A receptor-associated protein Homo sapiens 119-126 16303767-0 2006 Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. phosphatidylethanolamine 34-58 GABA type A receptor associated protein like 2 Homo sapiens 132-139 16303767-1 2006 In yeast, phosphatidylethanolamine is a target of the Atg8 modifier in ubiquitylation-like reactions essential for autophagy. phosphatidylethanolamine 10-34 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 54-58 16303767-3 2006 The results of a recent study in which COS7 cells were incubated with [14C]ethanolamine for 48 h suggested that phosphatidylethanolamine is a target of LC3. phosphatidylethanolamine 112-136 microtubule associated protein 1 light chain 3 alpha Homo sapiens 152-155 16303767-9 2006 In contrast, thin layer chromatography of phospholipids released on hAtg4B-digestion from endogenous LC3-phospholipid conjugate revealed that phosphatidylethanolamine, but not phosphatidylserine, is the predominant target phospholipid of LC3 in vivo. phosphatidylethanolamine 142-166 autophagy related 4B cysteine peptidase Homo sapiens 68-74 16303767-9 2006 In contrast, thin layer chromatography of phospholipids released on hAtg4B-digestion from endogenous LC3-phospholipid conjugate revealed that phosphatidylethanolamine, but not phosphatidylserine, is the predominant target phospholipid of LC3 in vivo. phosphatidylethanolamine 142-166 microtubule associated protein 1 light chain 3 alpha Homo sapiens 101-104 16303767-9 2006 In contrast, thin layer chromatography of phospholipids released on hAtg4B-digestion from endogenous LC3-phospholipid conjugate revealed that phosphatidylethanolamine, but not phosphatidylserine, is the predominant target phospholipid of LC3 in vivo. phosphatidylethanolamine 142-166 microtubule associated protein 1 light chain 3 alpha Homo sapiens 238-241 16024567-3 2006 AA is released from phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by phospholipase A2 (PLA2), or from phosphatidylinositol (PI) by phospholipase C (PLC) pathway. phosphatidylethanolamine 75-77 phospholipase A2 Oryctolagus cuniculus 100-104 16024567-3 2006 AA is released from phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by phospholipase A2 (PLA2), or from phosphatidylinositol (PI) by phospholipase C (PLC) pathway. phosphatidylethanolamine 75-77 LOC100009319 Oryctolagus cuniculus 144-159 16024567-3 2006 AA is released from phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by phospholipase A2 (PLA2), or from phosphatidylinositol (PI) by phospholipase C (PLC) pathway. phosphatidylethanolamine 75-77 LOC100009319 Oryctolagus cuniculus 161-164 16205618-3 2005 The shortage of alkaline phosphatase (ALP) alters the process of mineralization of skeleton causing a reduced transformation of phosphoethanolamine into phosphatidylethanolamine (cerebral phospholipid) with consequent high serum and urinary levels of phosphoethanolamine, a sensitive and highly specific marker for the disease. phosphatidylethanolamine 153-177 alkaline phosphatase, placental Homo sapiens 16-36 16363814-6 2005 Second, deprotonation of phosphatidic acid and lysophosphatidic acid was found to be strongly stimulated by the inclusion of phosphatidylethanolamine in the bilayer, indicating that lipid headgroup charge depends on local lipid composition and will vary between the different subcellular locations of (L)PA. phosphatidylethanolamine 125-149 lipoprotein(a) Homo sapiens 302-306 16183633-1 2005 Reversible modification of Atg8 with phosphatidylethanolamine is crucial for autophagy, the bulk degradation system conserved in eukaryotic cells. phosphatidylethanolamine 37-61 GABA type A receptor associated protein like 1 Homo sapiens 27-31 16144842-1 2005 In mammals, the only endogenous pathway for choline biosynthesis is the methylation of phosphatidylethanolamine to phosphatidylcholine (PC) by phosphatidylethanolamine N-methyltransferase (PEMT) coupled to PC degradation. phosphatidylethanolamine 87-111 phosphatidylethanolamine N-methyltransferase Mus musculus 143-187 16144842-1 2005 In mammals, the only endogenous pathway for choline biosynthesis is the methylation of phosphatidylethanolamine to phosphatidylcholine (PC) by phosphatidylethanolamine N-methyltransferase (PEMT) coupled to PC degradation. phosphatidylethanolamine 87-111 phosphatidylethanolamine N-methyltransferase Mus musculus 189-193 16459925-0 2005 Parathyroid hormone stimulates phosphatidylethanolamine hydrolysis by phospholipase D in osteoblastic cells. phosphatidylethanolamine 31-55 parathyroid hormone Rattus norvegicus 0-19 16243830-8 2005 Silencing of hPEBP4 potentiated tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis and cell cycle arrest in MCF-7 cells, which was due to the increased mitogen-activated protein kinase activation and the enhanced phosphatidylethanolamine externalization. phosphatidylethanolamine 220-244 phosphatidylethanolamine binding protein 4 Homo sapiens 13-19 16243830-8 2005 Silencing of hPEBP4 potentiated tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis and cell cycle arrest in MCF-7 cells, which was due to the increased mitogen-activated protein kinase activation and the enhanced phosphatidylethanolamine externalization. phosphatidylethanolamine 220-244 tumor necrosis factor Homo sapiens 32-59 16243830-8 2005 Silencing of hPEBP4 potentiated tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis and cell cycle arrest in MCF-7 cells, which was due to the increased mitogen-activated protein kinase activation and the enhanced phosphatidylethanolamine externalization. phosphatidylethanolamine 220-244 tumor necrosis factor Homo sapiens 61-70 16192276-1 2005 Most of the phosphatidylethanolamine (PE) in mammalian cells is synthesized by two pathways, the CDP-ethanolamine pathway and the phosphatidylserine (PS) decarboxylation pathway, the final steps of which operate at spatially distinct sites, the endoplasmic reticulum and mitochondria, respectively. phosphatidylethanolamine 12-36 cut like homeobox 1 Homo sapiens 97-100 16192276-1 2005 Most of the phosphatidylethanolamine (PE) in mammalian cells is synthesized by two pathways, the CDP-ethanolamine pathway and the phosphatidylserine (PS) decarboxylation pathway, the final steps of which operate at spatially distinct sites, the endoplasmic reticulum and mitochondria, respectively. phosphatidylethanolamine 38-40 cut like homeobox 1 Homo sapiens 97-100 16192276-8 2005 The amount and activity of a key enzyme of the CDP-ethanolamine pathway for PE synthesis, CTP:phosphoethanolamine cytidylyltransferase, were increased by 35-40 and 100%, respectively, in tissues of Pisd+/- mice, as judged by immunoblotting; PE synthesis from [3H]ethanolamine was correspondingly increased in hepatocytes. phosphatidylethanolamine 76-78 cut-like homeobox 1 Mus musculus 47-50 16192276-8 2005 The amount and activity of a key enzyme of the CDP-ethanolamine pathway for PE synthesis, CTP:phosphoethanolamine cytidylyltransferase, were increased by 35-40 and 100%, respectively, in tissues of Pisd+/- mice, as judged by immunoblotting; PE synthesis from [3H]ethanolamine was correspondingly increased in hepatocytes. phosphatidylethanolamine 76-78 phosphate cytidylyltransferase 2, ethanolamine Mus musculus 90-134 16192276-8 2005 The amount and activity of a key enzyme of the CDP-ethanolamine pathway for PE synthesis, CTP:phosphoethanolamine cytidylyltransferase, were increased by 35-40 and 100%, respectively, in tissues of Pisd+/- mice, as judged by immunoblotting; PE synthesis from [3H]ethanolamine was correspondingly increased in hepatocytes. phosphatidylethanolamine 76-78 phosphatidylserine decarboxylase Mus musculus 198-202 16162509-3 2005 Here we show that immobilization of cell surface PE by a PE-binding peptide blocks the RhoA inactivation in the late stage of cytokinesis. phosphatidylethanolamine 49-51 ras homolog family member A Homo sapiens 87-91 16205618-3 2005 The shortage of alkaline phosphatase (ALP) alters the process of mineralization of skeleton causing a reduced transformation of phosphoethanolamine into phosphatidylethanolamine (cerebral phospholipid) with consequent high serum and urinary levels of phosphoethanolamine, a sensitive and highly specific marker for the disease. phosphatidylethanolamine 153-177 alkaline phosphatase, placental Homo sapiens 38-41 15890686-1 2005 Activated protein C (APC) anticoagulant activity and the ability to be inhibited by auto-antibodies associated with thrombosis are strongly augmented by the presence of phosphatidylethanolamine (PE) and phospholipid oxidation. phosphatidylethanolamine 169-193 APC regulator of WNT signaling pathway Homo sapiens 21-24 15890686-1 2005 Activated protein C (APC) anticoagulant activity and the ability to be inhibited by auto-antibodies associated with thrombosis are strongly augmented by the presence of phosphatidylethanolamine (PE) and phospholipid oxidation. phosphatidylethanolamine 195-197 APC regulator of WNT signaling pathway Homo sapiens 21-24 15890686-9 2005 We conclude that antibodies to beta(2)-GPI inhibit APC function specifically and contribute to a hypercoaguable state by disrupting specific protein-protein interactions induced by oxidation of PE-containing membranes. phosphatidylethanolamine 194-196 apolipoprotein H Homo sapiens 31-42 15890686-9 2005 We conclude that antibodies to beta(2)-GPI inhibit APC function specifically and contribute to a hypercoaguable state by disrupting specific protein-protein interactions induced by oxidation of PE-containing membranes. phosphatidylethanolamine 194-196 APC regulator of WNT signaling pathway Homo sapiens 51-54 15994250-6 2005 METHODS: Rats sensitised with OVA were treated with the sPLA(2) inhibitor hyaluronic acid-linked phosphatidyl ethanolamine (HyPE). phosphatidylethanolamine 97-122 phospholipase A2 group IIA Rattus norvegicus 56-63 15958390-6 2005 We have further investigated methylation demand and Hcy metabolism in liver-specific CTP:phosphocholine cytidylyltransferase-alpha (CTalpha) knockout mice, since flux through the phosphatidylethanolamine N-methyltransferase pathway is increased 2-fold to meet hepatic demand for phosphatidylcholine. phosphatidylethanolamine 179-203 phosphate cytidylyltransferase 1, choline, alpha isoform Mus musculus 132-139 16051517-5 2005 Expression of the N-terminal truncated form of plaA in yeast cells resulted in increased Ca(2+)-dependent PLA(2) activity with (14)C-labeled phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as substrates, compared with vector-transformed cells. phosphatidylethanolamine 170-194 phospholipase A2 activating protein Homo sapiens 47-51 16051517-5 2005 Expression of the N-terminal truncated form of plaA in yeast cells resulted in increased Ca(2+)-dependent PLA(2) activity with (14)C-labeled phosphatidylcholine (PC) and phosphatidylethanolamine (PE) as substrates, compared with vector-transformed cells. phosphatidylethanolamine 196-198 phospholipase A2 activating protein Homo sapiens 47-51 16040659-2 2005 In yeast, this encapsulation employs a set of autophagy (ATG) proteins that direct the conjugation of two ubiquitin-like protein tags, ATG8 and ATG12, to phosphatidylethanolamine and the ATG5 protein, respectively. phosphatidylethanolamine 154-178 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 135-139 16040659-2 2005 In yeast, this encapsulation employs a set of autophagy (ATG) proteins that direct the conjugation of two ubiquitin-like protein tags, ATG8 and ATG12, to phosphatidylethanolamine and the ATG5 protein, respectively. phosphatidylethanolamine 154-178 Atg12p Saccharomyces cerevisiae S288C 144-149 16874047-5 2005 Despite no obvious sequence homology with ubiquitin, the structure of AtATG12 shows a ubiquitin fold strikingly similar to those of mammalian homologs of Atg8, the other ubiquitin-like modifier essential for autophagy, which is conjugated to phosphatidylethanolamine. phosphatidylethanolamine 242-266 Ubiquitin-like superfamily protein Arabidopsis thaliana 70-77 15911624-3 2005 We now provide evidence that StarD10 interacts with phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by electron spin resonance measurement. phosphatidylethanolamine 81-105 StAR related lipid transfer domain containing 10 Homo sapiens 29-36 15911624-3 2005 We now provide evidence that StarD10 interacts with phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by electron spin resonance measurement. phosphatidylethanolamine 107-109 StAR related lipid transfer domain containing 10 Homo sapiens 29-36 16874047-5 2005 Despite no obvious sequence homology with ubiquitin, the structure of AtATG12 shows a ubiquitin fold strikingly similar to those of mammalian homologs of Atg8, the other ubiquitin-like modifier essential for autophagy, which is conjugated to phosphatidylethanolamine. phosphatidylethanolamine 242-266 GABA type A receptor associated protein like 1 Homo sapiens 154-158 15857831-4 2005 LC3-II is covalently attached to phosphatidylethanolamine on its C terminus, and it binds tightly to autophagosome membranes. phosphatidylethanolamine 33-57 microtubule associated protein 1 light chain 3 alpha Homo sapiens 0-3 15866882-10 2005 In contrast to cPLA(2)alpha, cPLA(2)zeta preferred phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 51-75 phospholipase A2, group IVF Mus musculus 29-40 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 StAR related lipid transfer domain containing 10 Homo sapiens 149-156 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 StAR related lipid transfer domain containing 10 Homo sapiens 158-165 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 ceramide transporter 1 Homo sapiens 170-177 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 steroidogenic acute regulatory protein Homo sapiens 112-118 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 StAR related lipid transfer domain containing 3 Homo sapiens 119-125 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 StAR related lipid transfer domain containing 5 Homo sapiens 126-132 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 StAR related lipid transfer domain containing 5 Homo sapiens 134-140 15976441-3 2005 Cholesterol, 25-hydroxycholesterol, phosphatidylcholine, phosphatidylethanolamine and ceramides are ligands for STARD1/STARD3/STARD5, STARD5, STARD2/STARD10, STARD10 and STARD11, respectively. phosphatidylethanolamine 57-81 phosphatidylcholine transfer protein Homo sapiens 142-148 16335792-0 2005 Docosahexaenoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression. phosphatidylethanolamine 32-56 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 110-115 16335792-0 2005 Docosahexaenoic acid-containing phosphatidylethanolamine enhances HL-60 cell differentiation by regulation of c-jun and c-myc expression. phosphatidylethanolamine 32-56 MYC proto-oncogene, bHLH transcription factor Homo sapiens 120-125 16335792-3 2005 In HL-60 cells treated with 50 microM 18:1/DHA-PE and 200 microM dbcAMP for 24 h, the expression level of c-jun mRNA and c-Jun protein were remarkably elevated compared to cells treated with dbcAMP alone. phosphatidylethanolamine 47-49 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 106-111 16335792-3 2005 In HL-60 cells treated with 50 microM 18:1/DHA-PE and 200 microM dbcAMP for 24 h, the expression level of c-jun mRNA and c-Jun protein were remarkably elevated compared to cells treated with dbcAMP alone. phosphatidylethanolamine 47-49 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 121-126 16335792-5 2005 On the other hand, the combine treatment of 18:1/DHA-PE and dbcAMP markedly reduced the expression level of c-myc oncogene during 48 h incubation. phosphatidylethanolamine 53-55 MYC proto-oncogene, bHLH transcription factor Homo sapiens 108-113 15840826-0 2005 Fusogenic Alzheimer"s peptide fragment Abeta (29-42) in interaction with lipid bilayers: secondary structure, dynamics, and specific interaction with phosphatidyl ethanolamine polar heads as revealed by solid-state NMR. phosphatidylethanolamine 150-175 amyloid beta precursor protein Homo sapiens 39-44 15829484-5 2005 In contrast, the protein level of phosphatidylethanolamine N-methyltransferase, an enzyme involved in PC synthesis via methylation of phosphatidylethanolamine, was decreased by 80% in the liver of Scd1-/- mice. phosphatidylethanolamine 34-58 stearoyl-Coenzyme A desaturase 1 Mus musculus 197-201 15904666-5 2005 The Can1p undelivered to the plasma membrane is fully active when reconstituted to a PE-containing vesicle system in vitro. phosphatidylethanolamine 85-87 arginine permease CAN1 Saccharomyces cerevisiae S288C 4-9 15806137-3 2005 The fatty acid composition of all major mitochondrial phospholipids, phosphatidylcholine (PC), phosphatidylethanolamine (PE), and cardiolipin (CL), changed in lymphoblasts from BTHS patients. phosphatidylethanolamine 95-119 tafazzin, phospholipid-lysophospholipid transacylase Homo sapiens 177-181 15893515-7 2005 Whereas NK-2 has no effect on phosphatidylcholine liposomes, it enhances the fluidity of phosphatidylethanolamine acyl chains and lowers the phase transition enthalpy of the gel to liquid cristalline transition. phosphatidylethanolamine 89-113 NK2 homeobox 1 Homo sapiens 8-12 15893515-8 2005 The most dramatic effect, however, was observed for the lamellar/inverted hexagonal transition of phosphatidylethanolamine which was reduced by more than 10 degrees C. Thus, NK-2 promotes a negative membrane curvature which can lead to the collapse of the phosphatidylethanolamine-rich bacterial cytoplasmic membrane. phosphatidylethanolamine 98-122 NK2 homeobox 1 Homo sapiens 174-178 15893515-8 2005 The most dramatic effect, however, was observed for the lamellar/inverted hexagonal transition of phosphatidylethanolamine which was reduced by more than 10 degrees C. Thus, NK-2 promotes a negative membrane curvature which can lead to the collapse of the phosphatidylethanolamine-rich bacterial cytoplasmic membrane. phosphatidylethanolamine 256-280 NK2 homeobox 1 Homo sapiens 174-178 16104390-1 2005 PEGylated (stealth) immunoliposomes covalently linked to antibodies against human gliofibrillary acidic protein (GFAP) were prepared by coupling the thiolated monoclonal anti-GFAP antibodies, D4, with a maleimide derivative of the phosphatidyl ethanolamine of the liposomal membrane. phosphatidylethanolamine 231-256 glial fibrillary acidic protein Homo sapiens 113-117 15966743-1 2005 The effect of nonlamellar-prone lipids, diacylglycerol (DG) and phosphatidylethanolamine (PE), on the stability of human cytochrome P450 1A2 (CYP1A2) was examined. phosphatidylethanolamine 64-88 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 121-140 15966743-1 2005 The effect of nonlamellar-prone lipids, diacylglycerol (DG) and phosphatidylethanolamine (PE), on the stability of human cytochrome P450 1A2 (CYP1A2) was examined. phosphatidylethanolamine 64-88 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 142-148 15966743-1 2005 The effect of nonlamellar-prone lipids, diacylglycerol (DG) and phosphatidylethanolamine (PE), on the stability of human cytochrome P450 1A2 (CYP1A2) was examined. phosphatidylethanolamine 90-92 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 121-140 15966743-1 2005 The effect of nonlamellar-prone lipids, diacylglycerol (DG) and phosphatidylethanolamine (PE), on the stability of human cytochrome P450 1A2 (CYP1A2) was examined. phosphatidylethanolamine 90-92 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 142-148 15966743-2 2005 When 100% phosphatidylcholine (PC) in standard vesicles was gradually replaced with either DG or PE, the stability of CYP1A2 increased; the incubation time-dependent destruction of spectrally detectable P450, decrease of catalytic activity, reduction of intrinsic fluorescence, and increased sensitivity to trypsin digestion were significantly alleviated. phosphatidylethanolamine 97-99 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 118-124 15576843-9 2005 Inhibition was essentially attributable to phosphatidylinositol mannosides (PIMs), namely PIM2 and PIM6, because the purified phosphatidylethanolamine, phosphatidylglycerol, and phosphatidylinositol were inactive. phosphatidylethanolamine 126-150 Pim-2 proto-oncogene, serine/threonine kinase Homo sapiens 90-94 15588231-6 2005 At the pH optimum of 2.5-3.5, the order of substrate preference of Plb1p and Plb2p is PtdSer (phosphatidylserine)>PtdIns>PtdCho (phosphatidylcholine>PtdEtn (phosphatidylethanolamine). phosphatidylethanolamine 166-190 lysophospholipase Saccharomyces cerevisiae S288C 67-72 15588231-6 2005 At the pH optimum of 2.5-3.5, the order of substrate preference of Plb1p and Plb2p is PtdSer (phosphatidylserine)>PtdIns>PtdCho (phosphatidylcholine>PtdEtn (phosphatidylethanolamine). phosphatidylethanolamine 166-190 lysophospholipase Saccharomyces cerevisiae S288C 77-82 15836921-1 2005 Choline is derived from the diet as well as from de novo methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 72-96 phosphatidylethanolamine N-methyltransferase Mus musculus 110-154 15836921-1 2005 Choline is derived from the diet as well as from de novo methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 72-96 phosphatidylethanolamine N-methyltransferase Mus musculus 156-160 15241571-2 2005 We studied the interaction of OmpT with the membrane-forming lipids phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) from the inner leaflet and lipopolysaccharide (LPS) from the outer leaflet of the outer membrane. phosphatidylethanolamine 68-92 outer membrane protease Escherichia coli 30-34 15241571-2 2005 We studied the interaction of OmpT with the membrane-forming lipids phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) from the inner leaflet and lipopolysaccharide (LPS) from the outer leaflet of the outer membrane. phosphatidylethanolamine 94-96 outer membrane protease Escherichia coli 30-34 15241571-4 2005 The molecular interaction of the lipids PE, PG, and LPS with OmpT was investigated by analysing molecular groups in the lipids originating from the apolar region (methylene groups), the interface region (ester), and the polar region (phosphates), and by analysing the acyl-chain melting-phase behaviour of the lipids. phosphatidylethanolamine 40-42 outer membrane protease Escherichia coli 61-65 15501933-0 2005 Phosphatidylethanolamine enhances rhodopsin photoactivation and transducin binding in a solid supported lipid bilayer as determined using plasmon-waveguide resonance spectroscopy. phosphatidylethanolamine 0-24 rhodopsin Homo sapiens 34-43 15258140-2 2004 In the yeast Saccharomyces cerevisiae, the primary route for the biosynthesis of PC consists of three consecutive methylation steps of phosphatidylethanolamine (PE) catalyzed by the phospholipid N-methyltransferases Cho2p and Opi3p. phosphatidylethanolamine 135-159 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 216-221 15544347-4 2004 Incorporation of phosphatidylethanolamine into the liposomes resulted in an increased partitioning of both isoforms of DGK to the membrane as well as an increased catalytic rate. phosphatidylethanolamine 17-41 diacylglycerol kinase beta Homo sapiens 119-122 15331603-2 2004 Hepatic cells express both an alpha and a beta2 isoform of CT and can also synthesize phosphatidylcholine via the sequential methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase. phosphatidylethanolamine 140-164 histocompatibility 2, O region beta locus Mus musculus 40-47 15342785-3 2004 In this study of phytosphingosine (PHS)-resistant yeast mutants, we isolated mutants for PDR5, an ABC transporter involved in drug efflux as well as in the flop of phosphatidylethanolamine. phosphatidylethanolamine 164-188 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 89-93 15302887-0 2004 A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization. phosphatidylethanolamine 14-38 tumor necrosis factor Homo sapiens 63-90 15294901-3 2004 Previously, we identified a lysosomal phospholipase A2, termed LPLA2, with specificity toward phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 118-142 phospholipase A2, group XV Mus musculus 28-54 15294901-3 2004 Previously, we identified a lysosomal phospholipase A2, termed LPLA2, with specificity toward phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 118-142 phospholipase A2, group XV Mus musculus 63-68 15652523-4 2005 Fluorescence analyses demonstrated that the BODIPY fatty acid--albumin complex was translocated into the lens, where the BODIPY fatty acid was incorporated in a time dependent manner into numerous lipids, including phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin. phosphatidylethanolamine 236-260 albumin Homo sapiens 63-70 15471866-4 2004 When all-trans-retinal was added to ABCA4 in the presence of phosphatidylethanolamine, approximately 0.9 mol of N-retinylidene-phosphatidylethanolamine and 0.3 mol of all-trans-retinal were bound per mol of ABCA4 with an apparent K(d) of 2-5 microm. phosphatidylethanolamine 61-85 ATP binding cassette subfamily A member 4 Homo sapiens 36-41 15471866-6 2004 One mole of N-retinyl-phosphatidylethanolamine, the reduced form of N-retinylidene-phosphatidylethanolamine, bound per mol of ABCA4, whereas 0.3 mol of all-trans-retinal were bound in the absence of phosphatidylethanolamine. phosphatidylethanolamine 22-46 ATP binding cassette subfamily A member 4 Homo sapiens 126-131 15258140-2 2004 In the yeast Saccharomyces cerevisiae, the primary route for the biosynthesis of PC consists of three consecutive methylation steps of phosphatidylethanolamine (PE) catalyzed by the phospholipid N-methyltransferases Cho2p and Opi3p. phosphatidylethanolamine 135-159 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 226-231 15258140-2 2004 In the yeast Saccharomyces cerevisiae, the primary route for the biosynthesis of PC consists of three consecutive methylation steps of phosphatidylethanolamine (PE) catalyzed by the phospholipid N-methyltransferases Cho2p and Opi3p. phosphatidylethanolamine 161-163 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 216-221 15277523-1 2004 In an analogous manner to protein ubiquitination, The C terminus of Atg8p, a yeast protein essential for autophagy, conjugates to a head group of phosphatidylethanolamine via an amide bond. phosphatidylethanolamine 146-170 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 68-73 15258140-2 2004 In the yeast Saccharomyces cerevisiae, the primary route for the biosynthesis of PC consists of three consecutive methylation steps of phosphatidylethanolamine (PE) catalyzed by the phospholipid N-methyltransferases Cho2p and Opi3p. phosphatidylethanolamine 161-163 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 226-231 15194695-11 2004 Consistently, the covalent linkage of Atg8 to the lipid phosphatidylethanolamine is significantly retarded. phosphatidylethanolamine 56-80 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 38-42 15355352-7 2004 Phosphatidylethanolamine and phosphatidic acid were shown to be also hydrolysed by AtLCAT3, although less efficiently than phosphatidylcholine. phosphatidylethanolamine 0-24 lecithin:cholesterol acyltransferase 3 Arabidopsis thaliana 83-90 15450206-8 2004 Phosphatidylcholine, phosphatidylethanolamine, and LPE plasmalogen (LPEP), but not choline, also activated TGF-beta1. phosphatidylethanolamine 21-45 transforming growth factor, beta 1 Rattus norvegicus 107-116 15333038-6 2004 In this study, we demonstrate that ISI values of thromboplastin reagents based on relipidated, recombinant human tissue factor can be controlled by a combination of changes in the phospholipid content (in particular, the levels of phosphatidylserine and phosphatidylethanolamine) and ionic strength. phosphatidylethanolamine 254-278 coagulation factor III, tissue factor Homo sapiens 113-126 15242551-6 2004 The oxidation products of 1- and/or 2-oleoyl phosphatidylcholine or phosphatidylethanolamine were the most potent inhibitors of TFPI activity, whereas those of arachidonyl phosphatidylcholine possessed only a weak inhibitory effect on the TFPI activity. phosphatidylethanolamine 68-92 tissue factor pathway inhibitor Homo sapiens 128-132 15130088-1 2004 PtdSer (phosphatidylserine) synthesis in mammalian cells occurs through the exchange of L-serine with the base moieties of phosphatidylcholine and phosphatidylethanolamine, which is catalysed by PSS (PtdSer synthase) 1 and 2 respectively. phosphatidylethanolamine 147-171 phosphatidylserine synthase 1 Homo sapiens 200-224 15155809-6 2004 The loss of Atg21 results in the absence of Atg8 from the pre-autophagosomal structure (PAS), which may be ascribed to a reduced rate of conjugation of Atg8 to phosphatidylethanolamine. phosphatidylethanolamine 160-184 WD repeat domain, phosphoinositide interacting 2 Homo sapiens 12-17 15155809-6 2004 The loss of Atg21 results in the absence of Atg8 from the pre-autophagosomal structure (PAS), which may be ascribed to a reduced rate of conjugation of Atg8 to phosphatidylethanolamine. phosphatidylethanolamine 160-184 GABA type A receptor associated protein like 1 Homo sapiens 152-156 15249668-3 2004 Drs2p from budding yeast localizes to the trans-Golgi network (TGN), and here we show that this membrane contains an ATP-dependent APLT that flips 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) PS and PE derivatives from the luminal to the cytosolic leaflet. phosphatidylethanolamine 193-195 aminophospholipid-translocating P4-type ATPase DRS2 Saccharomyces cerevisiae S288C 0-5 15225629-0 2004 The selective utilization of substrates in vivo by the phosphatidylethanolamine and phosphatidylcholine biosynthetic enzymes Ept1p and Cpt1p in yeast. phosphatidylethanolamine 55-79 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 125-130 15225629-0 2004 The selective utilization of substrates in vivo by the phosphatidylethanolamine and phosphatidylcholine biosynthetic enzymes Ept1p and Cpt1p in yeast. phosphatidylethanolamine 55-79 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 135-140 15225629-1 2004 In yeast, the aminoalcohol phosphotransferases Ept1p and Cpt1p catalyze the final steps in the CDP-ethanolamine and CDP-choline routes leading to phosphatidylethanolamine (PE) and phosphatidylcholine (PC), respectively. phosphatidylethanolamine 146-170 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 47-52 15225629-1 2004 In yeast, the aminoalcohol phosphotransferases Ept1p and Cpt1p catalyze the final steps in the CDP-ethanolamine and CDP-choline routes leading to phosphatidylethanolamine (PE) and phosphatidylcholine (PC), respectively. phosphatidylethanolamine 146-170 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 57-62 15225629-1 2004 In yeast, the aminoalcohol phosphotransferases Ept1p and Cpt1p catalyze the final steps in the CDP-ethanolamine and CDP-choline routes leading to phosphatidylethanolamine (PE) and phosphatidylcholine (PC), respectively. phosphatidylethanolamine 172-174 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 47-52 15225629-1 2004 In yeast, the aminoalcohol phosphotransferases Ept1p and Cpt1p catalyze the final steps in the CDP-ethanolamine and CDP-choline routes leading to phosphatidylethanolamine (PE) and phosphatidylcholine (PC), respectively. phosphatidylethanolamine 172-174 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 57-62 15225629-3 2004 Analysis of newly synthesized PE and PC using electrospray ionization tandem mass spectrometry revealed that PE and PC produced by Ept1p and Cpt1p have different species compositions, demonstrating that the enzymes consume distinct sets of diacylglycerol species in vivo. phosphatidylethanolamine 30-32 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 131-136 15225629-3 2004 Analysis of newly synthesized PE and PC using electrospray ionization tandem mass spectrometry revealed that PE and PC produced by Ept1p and Cpt1p have different species compositions, demonstrating that the enzymes consume distinct sets of diacylglycerol species in vivo. phosphatidylethanolamine 30-32 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 141-146 15225629-3 2004 Analysis of newly synthesized PE and PC using electrospray ionization tandem mass spectrometry revealed that PE and PC produced by Ept1p and Cpt1p have different species compositions, demonstrating that the enzymes consume distinct sets of diacylglycerol species in vivo. phosphatidylethanolamine 109-111 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 131-136 15225629-3 2004 Analysis of newly synthesized PE and PC using electrospray ionization tandem mass spectrometry revealed that PE and PC produced by Ept1p and Cpt1p have different species compositions, demonstrating that the enzymes consume distinct sets of diacylglycerol species in vivo. phosphatidylethanolamine 109-111 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 141-146 15320789-11 2004 The auto-activation of PHBP was accelerated in the presence of dextran sulfate or phosphatidylethanolamine as well as factor XII of the coagulation system. phosphatidylethanolamine 82-106 hyaluronan binding protein 2 Homo sapiens 23-27 14697519-1 2004 CTP: ethanolaminephosphate cytidylyltransferase (Pcyt2) is an important regulatory enzyme in phosphatidylethanolamine and plasmalogen biosynthesis. phosphatidylethanolamine 93-117 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 49-54 15551655-14 2004 Other substances, such as proteoglycans and phosphatidylethanolamine-bound hyaluronic acid, may interfere with the actions of interferon-gamma. phosphatidylethanolamine 44-68 interferon gamma Homo sapiens 126-142 15202762-1 2004 Lysophosphatidylcholine (lyso-PTC) is formed by phospholipase A2 (PLA2) from phosphatidylcholine (PTC), that is produced through phosphatidylethanolamine (PTE) methylation. phosphatidylethanolamine 129-153 phospholipase A2 group IB Homo sapiens 48-64 15202762-1 2004 Lysophosphatidylcholine (lyso-PTC) is formed by phospholipase A2 (PLA2) from phosphatidylcholine (PTC), that is produced through phosphatidylethanolamine (PTE) methylation. phosphatidylethanolamine 129-153 phospholipase A2 group IB Homo sapiens 66-70 15202762-1 2004 Lysophosphatidylcholine (lyso-PTC) is formed by phospholipase A2 (PLA2) from phosphatidylcholine (PTC), that is produced through phosphatidylethanolamine (PTE) methylation. phosphatidylethanolamine 155-158 phospholipase A2 group IB Homo sapiens 48-64 15202762-1 2004 Lysophosphatidylcholine (lyso-PTC) is formed by phospholipase A2 (PLA2) from phosphatidylcholine (PTC), that is produced through phosphatidylethanolamine (PTE) methylation. phosphatidylethanolamine 155-158 phospholipase A2 group IB Homo sapiens 66-70 14985347-5 2004 Genetic manipulations to increase phosphatidylethanolamine levels in gpi7Delta cells by overexpression of PSD1 restore cell growth at 37 degrees C without restoring the addition of a substituent to Man2. phosphatidylethanolamine 34-58 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 106-110 15121302-5 2004 Inclusion of mannosylated phosphatidylethanolamine (Man-PE) for targeting to the mannose receptor (MR) increased the interaction of negatively charged liposomes with both human and murine DCs. phosphatidylethanolamine 26-50 mannose receptor C-type 1 Homo sapiens 81-97 15121302-5 2004 Inclusion of mannosylated phosphatidylethanolamine (Man-PE) for targeting to the mannose receptor (MR) increased the interaction of negatively charged liposomes with both human and murine DCs. phosphatidylethanolamine 26-50 mannose receptor C-type 1 Homo sapiens 99-101 15169837-4 2004 Because yeast Atg8 is conjugated with phosphatidylethanolamine (PE) by a ubiquitin-like system, it has been hypothesized that LC3 is modified in a similar manner. phosphatidylethanolamine 38-62 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 14-18 15169837-4 2004 Because yeast Atg8 is conjugated with phosphatidylethanolamine (PE) by a ubiquitin-like system, it has been hypothesized that LC3 is modified in a similar manner. phosphatidylethanolamine 64-66 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 14-18 14736886-3 2004 A second conjugation reaction, Aut7/Atg8 lipidation with phosphatidylethanolamine, as well as a protein kinase complex and a phosphatidylinositol 3-kinase complex are also required for macroautophagy in yeast. phosphatidylethanolamine 57-81 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 31-35 14736886-3 2004 A second conjugation reaction, Aut7/Atg8 lipidation with phosphatidylethanolamine, as well as a protein kinase complex and a phosphatidylinositol 3-kinase complex are also required for macroautophagy in yeast. phosphatidylethanolamine 57-81 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 36-40 15224966-7 2004 Additionally, it has been found that in mitochondria of the TNF (tumor necrosis factor)-sensitive cells (WEHI-164 line), the content of PA is larger than in mitochondria of the TNF-insensitive cells (C6 line), with this difference being mainly provided by PA incorporated in phosphatidylethanolamine and especially, cardiolipin. phosphatidylethanolamine 275-299 tumor necrosis factor Homo sapiens 60-63 15224966-7 2004 Additionally, it has been found that in mitochondria of the TNF (tumor necrosis factor)-sensitive cells (WEHI-164 line), the content of PA is larger than in mitochondria of the TNF-insensitive cells (C6 line), with this difference being mainly provided by PA incorporated in phosphatidylethanolamine and especially, cardiolipin. phosphatidylethanolamine 275-299 tumor necrosis factor Homo sapiens 65-86 14695258-7 2004 Addition of annexin 12 (0.25-4.0 microM) to the trans side of bilayers containing an 80:20 ratio of phosphatidylethanolamine/phosphatidylserine decreased RyR2 diffusion in a concentration-dependent manner. phosphatidylethanolamine 100-124 ryanodine receptor 2 Homo sapiens 154-158 14675982-3 2004 In the same group, HDL3 phosphatidylcholine increased (P<0.001) and HDL3 phosphatidylethanolamine decreased (P<0.01). phosphatidylethanolamine 76-100 HDL3 Homo sapiens 71-75 14557275-4 2003 Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids. phosphatidylethanolamine 61-85 diacylglycerol O-acyltransferase 1 Homo sapiens 131-135 14557275-4 2003 Both acylation and de novo synthesis of phosphatidylcholine, phosphatidylethanolamine, and sphingomyelin were reduced by 30-40% in DGAT cells compared with controls, suggesting that DGAT used substrates for triacylglycerol synthesis that had originally been destined to produce phospholipids. phosphatidylethanolamine 61-85 diacylglycerol O-acyltransferase 1 Homo sapiens 182-186 14690448-0 2003 Membrane properties induced by anionic phospholipids and phosphatidylethanolamine are critical for the membrane binding and catalytic activity of human cytochrome P450 3A4. phosphatidylethanolamine 57-81 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 152-171 14690448-5 2003 These results suggest that PA and PE might help the binding of CYP3A4 to the membrane and the interaction with NPR. phosphatidylethanolamine 34-36 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 63-69 14690448-5 2003 These results suggest that PA and PE might help the binding of CYP3A4 to the membrane and the interaction with NPR. phosphatidylethanolamine 34-36 neuronal pentraxin receptor Homo sapiens 111-114 14514684-7 2003 Moreover, we demonstrate for the first time that phosphatidylcholine and phosphatidylethanolamine, which are the main components of the mitochondrial outer membrane, are potent activators of both enzymatic activities of CoA synthase in vitro. phosphatidylethanolamine 73-97 Coenzyme A synthase Homo sapiens 220-232 14596606-10 2003 Alpha-synuclein exhibits a selectivity of interaction with different phospholipid spin labels when bound to phosphatidylglycerol membranes in the following order: stearic acid > cardiolipin > phosphatidylcholine > phosphatidylglycerol approximately phosphatidylethanolamine > phosphatidic acid approximately phosphatidylserine > N-acyl phosphatidylethanolamine > diglyceride. phosphatidylethanolamine 258-282 synuclein alpha Homo sapiens 0-15 15165032-5 2004 Phospholipase A2 (PLA2) hydrolysis of the PC, PI, and PE fractions indicated that the arachidonic acid formed from anandamide was esterified predominately into sn-2 position of the endothelial phospholipids. phosphatidylethanolamine 54-56 phospholipase A2, group IB, pancreas Mus musculus 0-16 15165032-5 2004 Phospholipase A2 (PLA2) hydrolysis of the PC, PI, and PE fractions indicated that the arachidonic acid formed from anandamide was esterified predominately into sn-2 position of the endothelial phospholipids. phosphatidylethanolamine 54-56 phospholipase A2, group IB, pancreas Mus musculus 18-22 14729070-3 2003 When platelets were preesterified with either 25 microM 9t, 11t-CLA or 9c, 11c-CLA, CLA incorporation in total platelet lipids increased from 0.24% to 0.31% and 0.38%, and most of this increase was found to be in the phosphatidyl choline and phosphatidyl ethanolamine subclasses. phosphatidylethanolamine 242-267 olfactory receptor family 1 subfamily L member 1 Homo sapiens 68-73 14603468-3 2003 Since the main site of PLA2 action in inflammatory processes is the cell membrane, we synthesized extracellular PLA2 inhibitors (ExPLIs) composed of N-derivatized phosphatidyl-ethanolamine linked to polymeric carriers. phosphatidylethanolamine 163-188 phospholipase A2 group IB Rattus norvegicus 112-116 14652352-5 2003 Moreover, cells treated with 50 micro mol/L of cis-9, trans-11 or trans-10, cis-12 CLA had a lower amount of arachidonic acid in their phosphatidylethanolamine fraction and a lower mRNA concentration and activity of secretory phospholipase A(2) than control cells (P < 0.05). phosphatidylethanolamine 135-159 selectin P ligand Homo sapiens 83-86 12837848-1 2003 Phosphatidylcholine (PC) is made in the liver by the CDP-choline pathway and via phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the conversion of phosphatidylethanolamine to PC. phosphatidylethanolamine 81-105 phosphatidylethanolamine N-methyltransferase Mus musculus 127-131 14608048-1 2003 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. phosphatidylethanolamine 81-105 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 14608048-1 2003 Phosphatidylethanolamine-N-methyltransferase (PEMT) catalyzes the methylation of phosphatidylethanolamine to form phosphatidylcholine (PC) and represents one of the two major pathways for PC biosynthesis. phosphatidylethanolamine 81-105 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 12962493-1 2003 The rod outer segment (ROS) ABC transporter (ABCR) plays an important role in the outer segment of retinal rod cells, where it functions as a transporter of all-trans retinal, most probably as the complex lipid, retinylidene-phosphatidyl-ethanolamine. phosphatidylethanolamine 225-250 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 28-43 12962493-1 2003 The rod outer segment (ROS) ABC transporter (ABCR) plays an important role in the outer segment of retinal rod cells, where it functions as a transporter of all-trans retinal, most probably as the complex lipid, retinylidene-phosphatidyl-ethanolamine. phosphatidylethanolamine 225-250 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 45-49 12842883-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT) is a quatrotopic membrane protein that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine through three sequential methylation reactions. phosphatidylethanolamine 119-143 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-44 12842883-1 2003 Phosphatidylethanolamine N-methyltransferase (PEMT) is a quatrotopic membrane protein that catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine through three sequential methylation reactions. phosphatidylethanolamine 119-143 phosphatidylethanolamine N-methyltransferase Homo sapiens 46-50 12842885-4 2003 In Drosophila cells, the endogenous SCAP/SREBP complex is transported to Golgi, but transport is blocked by phosphatidylethanolamine instead of sterols. phosphatidylethanolamine 108-132 SREBP cleavage activating protein Drosophila melanogaster 36-40 12842885-4 2003 In Drosophila cells, the endogenous SCAP/SREBP complex is transported to Golgi, but transport is blocked by phosphatidylethanolamine instead of sterols. phosphatidylethanolamine 108-132 Sterol regulatory element binding protein Drosophila melanogaster 41-46 12799368-10 2003 Phospholipid composition analysis of the gis1 Delta mutant showed that Gis1p played a role in regulating the cellular level of diacylglycerol pyrophosphate, as well as the levels of the major phospholipids phosphatidylethanolamine and phosphatidylcholine. phosphatidylethanolamine 206-230 histone demethylase GIS1 Saccharomyces cerevisiae S288C 41-45 12912985-1 2003 Phosphatidylserine (PtdSer) in mammalian cells is synthesized through the action of PtdSer synthase (PSS) 1 and 2, which catalyze the conversion of phosphatidylcholine and phosphatidylethanolamine, respectively, to PtdSer. phosphatidylethanolamine 172-196 phosphatidylserine synthase 1 Homo sapiens 84-113 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). phosphatidylethanolamine 137-161 interleukin 6 Homo sapiens 62-66 12837922-9 2003 Blockade of phosphatidylcholine and phosphatidyl-ethanolamine transfer by a 60 min, 56 degrees C heating step or with anti-PLTP antibody revealed that PLTP accounts for almost 80% of the phospholipid transfer activity present in seminal plasma. phosphatidylethanolamine 36-61 phospholipid transfer protein Homo sapiens 151-155 12859204-5 2003 Compared to wild-type littermates, Abca1(-/-) HDL had a 4-fold increase in PC, whereas lysophosphatidylcholine (LPC) (125-fold), sphingomyelin (SPH) (49-fold), and phosphatidylethanolamine (PE) (18-fold) showed even higher increases. phosphatidylethanolamine 164-188 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 35-40 12859204-5 2003 Compared to wild-type littermates, Abca1(-/-) HDL had a 4-fold increase in PC, whereas lysophosphatidylcholine (LPC) (125-fold), sphingomyelin (SPH) (49-fold), and phosphatidylethanolamine (PE) (18-fold) showed even higher increases. phosphatidylethanolamine 190-192 ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus 35-40 12689336-9 2003 Annexin A11 binds to acidic phospholipids and to phosphatidylethanolamine in the presence of calcium; weaker calcium-independent binding to phosphatidylserine, phosphatidic acid and phosphatidylethanolamine was also observed. phosphatidylethanolamine 49-73 annexin A11 Mus musculus 0-11 12689336-9 2003 Annexin A11 binds to acidic phospholipids and to phosphatidylethanolamine in the presence of calcium; weaker calcium-independent binding to phosphatidylserine, phosphatidic acid and phosphatidylethanolamine was also observed. phosphatidylethanolamine 182-206 annexin A11 Mus musculus 0-11 12962277-4 2003 In addition, bilayers containing phosphatidylethanolamine bind NAP-22 in the absence of cholesterol. phosphatidylethanolamine 33-57 brain abundant membrane attached signal protein 1 Homo sapiens 63-69 14614262-1 2003 Hippocampal cholinergic neurostimulating peptide precursor protein (HCNP-pp) is a unique multifunctional protein, being not only the precursor of HCNP, which promotes the phenotype development of septo-hippocampal cholinergic neurons, but also the binding protein of phosphatidylethanolamine, ATP, Raf-1 kinase (known as "Raf-1 kinase inhibitory factor" in peripheral organs), and serine protease. phosphatidylethanolamine 267-291 phosphatidylethanolamine binding protein 1 Mus musculus 0-66 14614262-1 2003 Hippocampal cholinergic neurostimulating peptide precursor protein (HCNP-pp) is a unique multifunctional protein, being not only the precursor of HCNP, which promotes the phenotype development of septo-hippocampal cholinergic neurons, but also the binding protein of phosphatidylethanolamine, ATP, Raf-1 kinase (known as "Raf-1 kinase inhibitory factor" in peripheral organs), and serine protease. phosphatidylethanolamine 267-291 phosphatidylethanolamine binding protein 1 Mus musculus 68-75 14614262-1 2003 Hippocampal cholinergic neurostimulating peptide precursor protein (HCNP-pp) is a unique multifunctional protein, being not only the precursor of HCNP, which promotes the phenotype development of septo-hippocampal cholinergic neurons, but also the binding protein of phosphatidylethanolamine, ATP, Raf-1 kinase (known as "Raf-1 kinase inhibitory factor" in peripheral organs), and serine protease. phosphatidylethanolamine 267-291 phosphatidylethanolamine binding protein 1 Mus musculus 68-72 12787934-8 2003 Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively. phosphatidylethanolamine 267-291 NK2 homeobox 1 Homo sapiens 77-81 12787934-8 2003 Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively. phosphatidylethanolamine 267-291 NK2 homeobox 1 Homo sapiens 155-159 12787934-8 2003 Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively. phosphatidylethanolamine 293-295 NK2 homeobox 1 Homo sapiens 77-81 12787934-8 2003 Utilizing fluorescence and biosensor assays, we could show that on one hand, NK-2 strongly interacts with negatively charged membranes; on the other hand, NK-2 is able to discriminate, without the necessity of negative charges, between the zwitterionic phospholipids phosphatidylethanolamine (PE) and phosphatidylcholine (PC), the major constituents of the outer leaflet of the cytoplasmic membranes of bacteria and mammalian cells, respectively. phosphatidylethanolamine 293-295 NK2 homeobox 1 Homo sapiens 155-159 12843651-5 2003 There was a significant correlation between the Delta6-desaturase activity and liver microsomal PE concentration, but not PC concentration, or the proportion of PC and PE or the PC/PE ratio. phosphatidylethanolamine 96-98 fatty acid desaturase 2 Rattus norvegicus 54-65 12926382-5 2003 Examination of A2-Rh and A2-PE (the precursor of A2E) fluorescence in relation to all-trans-retinal concentration indicated that whereas A2-PE formation is favored over that of A2-Rh, for a single rhodopsin molecule only one phosphatidylethanolamine molecule is available to react with all-trans-retinal; this phosphatidylethanolamine is probably tightly associated with the protein. phosphatidylethanolamine 225-249 rhodopsin Homo sapiens 197-206 12926382-5 2003 Examination of A2-Rh and A2-PE (the precursor of A2E) fluorescence in relation to all-trans-retinal concentration indicated that whereas A2-PE formation is favored over that of A2-Rh, for a single rhodopsin molecule only one phosphatidylethanolamine molecule is available to react with all-trans-retinal; this phosphatidylethanolamine is probably tightly associated with the protein. phosphatidylethanolamine 310-334 rhodopsin Homo sapiens 197-206 12784613-7 2003 The results obtained here, together with those in our previous report, suggest that quantity and type of dietary protein might affect the delta 6-desaturase activity through an alteration of the liver microsomal profile of phospholipids, especially PE, and that the alteration of phospholipid profile might be mediated by a hepatic SAM concentration that reflects the dietary methionine level. phosphatidylethanolamine 249-251 fatty acid desaturase 2 Rattus norvegicus 138-156 12466019-1 2003 Choline is an essential nutrient for humans and is derived from the diet as well as from de novo synthesis involving methylation of phosphatidylethanolamine catalysed by the enzyme phosphatidylethanolamine N -methyltransferase (PEMT). phosphatidylethanolamine 132-156 phosphatidylethanolamine N-methyltransferase Homo sapiens 181-226 12466019-1 2003 Choline is an essential nutrient for humans and is derived from the diet as well as from de novo synthesis involving methylation of phosphatidylethanolamine catalysed by the enzyme phosphatidylethanolamine N -methyltransferase (PEMT). phosphatidylethanolamine 132-156 phosphatidylethanolamine N-methyltransferase Homo sapiens 228-232 12502717-6 2003 Electrospray ionization mass spectrometric analysis of membrane extracts revealed that overexpression of cPLA(2)gamma increased the proportion of polyunsaturated fatty acids in phosphatidylethanolamine, suggesting that the enzyme modulates the phospholipid composition. phosphatidylethanolamine 177-201 phospholipase A2 group IVC Homo sapiens 105-117 12732938-8 2003 Total intracellular PL contents were also unchanged; however, IL-6 led to significant changes in PL composition including an increase in phosphatidylethanolamine (PE) and sphingomyelin (SM) and a decrease in phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) ( p<0.05). phosphatidylethanolamine 163-165 interleukin 6 Homo sapiens 62-66 12603829-3 2003 Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS). phosphatidylethanolamine 109-133 palmitoyl-protein thioesterase 1 Homo sapiens 32-36 12603829-3 2003 Compared with the controls, the INCL brains contained proportionally more phosphatidylcholine (PC), and less phosphatidylethanolamine (PE) and phosphatidylserine (PS). phosphatidylethanolamine 135-137 palmitoyl-protein thioesterase 1 Homo sapiens 32-36 12612149-5 2003 The activities of the Delta5-, Delta6- and Delta9-desaturases in liver microsomes were significantly decreased by eritadenine and ethanolamine; there was a significant correlation between the activity of Delta5- or Delta6-desaturase and the proportion of PE in the total phospholipids or the PC/PE ratio. phosphatidylethanolamine 255-257 fatty acid desaturase 2 Rattus norvegicus 37-61 12612149-5 2003 The activities of the Delta5-, Delta6- and Delta9-desaturases in liver microsomes were significantly decreased by eritadenine and ethanolamine; there was a significant correlation between the activity of Delta5- or Delta6-desaturase and the proportion of PE in the total phospholipids or the PC/PE ratio. phosphatidylethanolamine 255-257 fatty acid desaturase 2 Rattus norvegicus 49-60 12612149-5 2003 The activities of the Delta5-, Delta6- and Delta9-desaturases in liver microsomes were significantly decreased by eritadenine and ethanolamine; there was a significant correlation between the activity of Delta5- or Delta6-desaturase and the proportion of PE in the total phospholipids or the PC/PE ratio. phosphatidylethanolamine 295-297 fatty acid desaturase 2 Rattus norvegicus 37-61 12612149-5 2003 The activities of the Delta5-, Delta6- and Delta9-desaturases in liver microsomes were significantly decreased by eritadenine and ethanolamine; there was a significant correlation between the activity of Delta5- or Delta6-desaturase and the proportion of PE in the total phospholipids or the PC/PE ratio. phosphatidylethanolamine 295-297 fatty acid desaturase 2 Rattus norvegicus 49-60 12631737-4 2003 Loss of Dnf1p and Dnf2p virtually abolished ATP-dependent transport of NBD-labeled phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner plasma membrane leaflet, leaving transport of sphingolipid analogs unaffected. phosphatidylethanolamine 83-107 aminophospholipid-translocating P4-type ATPase DNF1 Saccharomyces cerevisiae S288C 8-13 12631737-4 2003 Loss of Dnf1p and Dnf2p virtually abolished ATP-dependent transport of NBD-labeled phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner plasma membrane leaflet, leaving transport of sphingolipid analogs unaffected. phosphatidylethanolamine 83-107 aminophospholipid-translocating P4-type ATPase DNF2 Saccharomyces cerevisiae S288C 18-23 12631737-6 2003 Phosphatidylethanolamine exposure by Deltadnf1Deltadnf2 cells further increased upon removal of Drs2p, an ATPase II homolog in the yeast Golgi. phosphatidylethanolamine 0-24 aminophospholipid-translocating P4-type ATPase DRS2 Saccharomyces cerevisiae S288C 96-101 12482759-3 2003 A potential source for homocysteine is methylation of the lipid phosphatidylethanolamine to phosphatidylcholine by phosphatidylethanolamine N-methyltransferase in the liver. phosphatidylethanolamine 64-88 phosphatidylethanolamine N-methyltransferase Mus musculus 115-159 12578350-5 2003 [SCRL: Liver-PC/Liver-phosphatidylethanolamine/SM/Cerebrosides/Chol, 1/1/1/1/2; Schroeder, R., London, E., and Brown, D. (1994) Proc. phosphatidylethanolamine 22-46 IZUMO family member 2 Homo sapiens 1-5 12589040-1 2003 The majority of mitochondrial phosphatidylethanolamine (PtdEtn), a phospholipid essential for aerobic growth of yeast cells, is synthesized by phosphatidylserine decarboxylase 1 (Psd1p) in the inner mitochondrial membrane (IMM). phosphatidylethanolamine 30-54 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 179-184 12589040-1 2003 The majority of mitochondrial phosphatidylethanolamine (PtdEtn), a phospholipid essential for aerobic growth of yeast cells, is synthesized by phosphatidylserine decarboxylase 1 (Psd1p) in the inner mitochondrial membrane (IMM). phosphatidylethanolamine 56-62 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 179-184 12931022-1 2003 OBJECTIVE: Hepatic phosphatidylethanolamine is converted into phosphatidylcholine by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT) when the dietary choline supply is inadequate. phosphatidylethanolamine 19-43 phosphatidylethanolamine N-methyltransferase Homo sapiens 96-140 12931022-1 2003 OBJECTIVE: Hepatic phosphatidylethanolamine is converted into phosphatidylcholine by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT) when the dietary choline supply is inadequate. phosphatidylethanolamine 19-43 phosphatidylethanolamine N-methyltransferase Homo sapiens 142-146 12393893-2 2002 Phosphatidylserine (PtdSer) synthesized in the endoplasmic reticulum and related membranes (mitochondria-associated membrane (MAM)) is transported to the mitochondria by unknown gene products and decarboxylated to form phosphatidylethanolamine at the inner membrane by PtdSer decarboxylase 1 (Psd1p). phosphatidylethanolamine 219-243 sarcoglycan gamma Homo sapiens 126-129 12180909-1 2002 The apoptotic protein Bax, in oligomeric form, is effective in promoting both leakage and lipid mixing in liposomes composed of cardiolipin and phosphatidylethanolamine and/or phosphatidylcholine, upon the addition of calcium. phosphatidylethanolamine 144-168 BCL2 associated X, apoptosis regulator Homo sapiens 22-25 12414547-1 2002 AIMS: Phosphatidylethanolamine N-methyltransferase (PEMT) catalyses the synthesis of phosphatidylcholine from phosphatidylethanolamine. phosphatidylethanolamine 110-134 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 6-50 12414547-1 2002 AIMS: Phosphatidylethanolamine N-methyltransferase (PEMT) catalyses the synthesis of phosphatidylcholine from phosphatidylethanolamine. phosphatidylethanolamine 110-134 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 52-56 12361952-2 2002 Pss1 and Pss2 are structurally similar (approximately 32% amino acid identity) but differ in their substrate specificities, with Pss1 using phosphatidylcholine for the serine exchange reaction and Pss2 using phosphatidylethanolamine. phosphatidylethanolamine 208-232 phosphatidylserine synthase 1 Mus musculus 0-4 12361952-2 2002 Pss1 and Pss2 are structurally similar (approximately 32% amino acid identity) but differ in their substrate specificities, with Pss1 using phosphatidylcholine for the serine exchange reaction and Pss2 using phosphatidylethanolamine. phosphatidylethanolamine 208-232 phosphatidylserine synthase 2 Mus musculus 9-13 12361952-2 2002 Pss1 and Pss2 are structurally similar (approximately 32% amino acid identity) but differ in their substrate specificities, with Pss1 using phosphatidylcholine for the serine exchange reaction and Pss2 using phosphatidylethanolamine. phosphatidylethanolamine 208-232 phosphatidylserine synthase 2 Mus musculus 197-201 12133835-4 2002 These results suggest that the mutation of ros3 affects the PE organization on the plasma membrane, rather than PE synthesis or overall organization of the membrane structures. phosphatidylethanolamine 60-62 Lem3p Saccharomyces cerevisiae S288C 43-47 12193594-1 2002 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC). phosphatidylethanolamine 80-104 phosphatidylethanolamine N-methyltransferase Mus musculus 0-44 12193594-1 2002 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine (PC). phosphatidylethanolamine 80-104 phosphatidylethanolamine N-methyltransferase Mus musculus 46-50 12133835-6 2002 Disruption of the ROS3 gene resulted in a marked decrease in the internalization of fluorescence-labeled analogs of PE and phosphatidylcholine, whereas the uptake of fluorescence-labeled phosphatidylserine and endocytic markers was not affected. phosphatidylethanolamine 116-118 Lem3p Saccharomyces cerevisiae S288C 18-22 12441642-9 2002 These observations suggest that Mpc1 preferentially utilizes phosphatidylethanolamine produced by Psd2 that is localized in Golgi/vacuole. phosphatidylethanolamine 61-85 pyruvate transporter MPC1 Saccharomyces cerevisiae S288C 32-36 12323087-7 2002 However, the LPD was associated specifically with lower liver (42.6 %) and plasma (19.4 %) phosphatidylcholine (PC), and plasma triacylglycerol (28.6 %) docosahexaenoic acid (DHA) concentrations in pregnant rats and reduced fetal brain PC- (26.1 %) and phosphatidylethanolamine- (25.6 %) DHA concentrations. phosphatidylethanolamine 253-277 acyl-CoA synthetase bubblegum family member 1 Rattus norvegicus 13-16 12441642-9 2002 These observations suggest that Mpc1 preferentially utilizes phosphatidylethanolamine produced by Psd2 that is localized in Golgi/vacuole. phosphatidylethanolamine 61-85 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 98-102 12441642-10 2002 fsr2-1 dpl1 Delta psd1delta strains showed slower growth than fsr2-1 dpl1delta psd2 delta, suggesting that Fsr2 enzyme depends more on Dpl1 and Psd1 for production of phosphatidylethanolamine. phosphatidylethanolamine 167-191 mannose-ethanolamine phosphotransferase MCD4 Saccharomyces cerevisiae S288C 0-4 12441642-10 2002 fsr2-1 dpl1 Delta psd1delta strains showed slower growth than fsr2-1 dpl1delta psd2 delta, suggesting that Fsr2 enzyme depends more on Dpl1 and Psd1 for production of phosphatidylethanolamine. phosphatidylethanolamine 167-191 mannose-ethanolamine phosphotransferase MCD4 Saccharomyces cerevisiae S288C 107-111 12110545-5 2002 Second, by photoaffinity labeling of the purified GLUT4 with 3-(trifluoromethyl)-3-(m-[(125)I]iodopenyl)diazirine, both labeled phosphatidylethanolamine and fatty acids (constituents of a GPI link) were recovered. phosphatidylethanolamine 128-152 solute carrier family 2 member 4 Rattus norvegicus 50-55 12221122-4 2002 Two human genes, CEPT1 and CPT1, code for the total compliment of activities that directly synthesize phosphatidylcholine and phosphatidylethanolamine through the CDP-alcohol pathways. phosphatidylethanolamine 126-150 choline/ethanolamine phosphotransferase 1 Homo sapiens 17-22 12221122-4 2002 Two human genes, CEPT1 and CPT1, code for the total compliment of activities that directly synthesize phosphatidylcholine and phosphatidylethanolamine through the CDP-alcohol pathways. phosphatidylethanolamine 126-150 carnitine palmitoyltransferase 1A Homo sapiens 27-31 12221122-5 2002 CEPT1 transfers a phosphobase from either CDP-choline or CDP-ethanolamine to diacylglycerol to synthesize both phosphatidylcholine and phosphatidylethanolamine, whereas CPT1 synthesizes phosphatidylcholine exclusively. phosphatidylethanolamine 135-159 choline/ethanolamine phosphotransferase 1 Homo sapiens 0-5 12100990-0 2002 Phosphatidyl ethanolamine is essential for targeting the arginine transporter Can1p to the plasma membrane of yeast. phosphatidylethanolamine 0-25 arginine permease CAN1 Saccharomyces cerevisiae S288C 78-83 12100990-1 2002 In continuation of our previous study, we show that phosphatidyl ethanolamine (PE) depletion affects, in addition to amino acid transporters, activities of at least two other proton motive force (pmf)-driven transporters (Ura4p and Mal6p). phosphatidylethanolamine 52-77 dihydroorotase Saccharomyces cerevisiae S288C 222-227 12100990-1 2002 In continuation of our previous study, we show that phosphatidyl ethanolamine (PE) depletion affects, in addition to amino acid transporters, activities of at least two other proton motive force (pmf)-driven transporters (Ura4p and Mal6p). phosphatidylethanolamine 79-81 dihydroorotase Saccharomyces cerevisiae S288C 222-227 12153242-2 2002 The title compound, Pea-PIP(2), possesses a phosphatidylethanolamine (PE) headgroup at the 1-position and a phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) headgroup at the 4-position. phosphatidylethanolamine 44-68 prolactin induced protein Homo sapiens 24-27 12153242-2 2002 The title compound, Pea-PIP(2), possesses a phosphatidylethanolamine (PE) headgroup at the 1-position and a phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P(2)) headgroup at the 4-position. phosphatidylethanolamine 70-72 prolactin induced protein Homo sapiens 24-27 12153579-1 2002 An unconventional phospholipase D (PLD) activity was identified recently in Saccharomyces cerevisiae which is Ca2+-dependent, preferentially hydrolyses phosphatidylethanolamine (PtdEtn) and phosphatidylserine and does not catalyse a transphosphatidylation with primary short-chain alcohols. phosphatidylethanolamine 152-176 phospholipase D Saccharomyces cerevisiae S288C 18-33 12153579-1 2002 An unconventional phospholipase D (PLD) activity was identified recently in Saccharomyces cerevisiae which is Ca2+-dependent, preferentially hydrolyses phosphatidylethanolamine (PtdEtn) and phosphatidylserine and does not catalyse a transphosphatidylation with primary short-chain alcohols. phosphatidylethanolamine 152-176 phospholipase D Saccharomyces cerevisiae S288C 35-38 12153579-1 2002 An unconventional phospholipase D (PLD) activity was identified recently in Saccharomyces cerevisiae which is Ca2+-dependent, preferentially hydrolyses phosphatidylethanolamine (PtdEtn) and phosphatidylserine and does not catalyse a transphosphatidylation with primary short-chain alcohols. phosphatidylethanolamine 178-184 phospholipase D Saccharomyces cerevisiae S288C 18-33 12153579-1 2002 An unconventional phospholipase D (PLD) activity was identified recently in Saccharomyces cerevisiae which is Ca2+-dependent, preferentially hydrolyses phosphatidylethanolamine (PtdEtn) and phosphatidylserine and does not catalyse a transphosphatidylation with primary short-chain alcohols. phosphatidylethanolamine 178-184 phospholipase D Saccharomyces cerevisiae S288C 35-38 12016218-5 2002 Furthermore, the extracellular domain of rat SR-BI fused with human Fc (SRBIecd-Fc) bound to PS with a dissociation equilibrium constant of 2.4 x 10(-7) m in a cell-free solid-phase assay, whereas other phospholipids including phosphatidylethanolamine, phosphatidylinositol, and phosphatidylcholine were poor binding targets. phosphatidylethanolamine 227-251 scavenger receptor class B, member 1 Rattus norvegicus 45-50 12095629-2 2002 Subsequently, we examined the potential control of angiogenesis by sPLA(2) inhibition, using a cell-impermeable sPLA(2) inhibitor composed of N-derivatized phosphatidyl-ethanolamine linked to hyaluronic acid. phosphatidylethanolamine 156-181 phospholipase A2 group X Homo sapiens 112-119 11602607-1 2001 Two yeast enzymes, Psd1p and Psd2p, catalyze the decarboxylation of phosphatidylserine to produce phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 98-122 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 19-24 12146947-4 2002 Using model membranes, we demonstrate a PE-dependent recruitment of p97/p47 to membranes, causing dramatic conformational rearrangements and favoring protein-lipid interactions. phosphatidylethanolamine 40-42 melanotransferrin Homo sapiens 68-71 12146947-4 2002 Using model membranes, we demonstrate a PE-dependent recruitment of p97/p47 to membranes, causing dramatic conformational rearrangements and favoring protein-lipid interactions. phosphatidylethanolamine 40-42 pleckstrin Homo sapiens 72-75 12146947-8 2002 Importantly, PE-mediated changes in secondary and tertiary structures are exclusively observed when p97 is complexed with p47, which is a prerequisite for membrane fusion. phosphatidylethanolamine 13-15 melanotransferrin Homo sapiens 100-103 12146947-8 2002 Importantly, PE-mediated changes in secondary and tertiary structures are exclusively observed when p97 is complexed with p47, which is a prerequisite for membrane fusion. phosphatidylethanolamine 13-15 pleckstrin Homo sapiens 122-125 12146947-9 2002 We therefore propose that at physiological conditions PE-induced conformational changes in p97/p47 are relevant in triggering this activity. phosphatidylethanolamine 54-56 melanotransferrin Homo sapiens 91-94 12146947-9 2002 We therefore propose that at physiological conditions PE-induced conformational changes in p97/p47 are relevant in triggering this activity. phosphatidylethanolamine 54-56 pleckstrin Homo sapiens 95-98 11923705-0 2002 Modulation of IFN-gamma-induced immunogenicity by phosphatidylethanolamine-linked hyaluronic acid. phosphatidylethanolamine 50-74 interferon gamma Homo sapiens 14-23 11960751-1 2002 Phosphatidylethanolamine N-methyltransferase 2 (PEMT2) is an isoform of PEMT that converts phosphatidylethanolamine to phosphatidylcholine in mammalian liver. phosphatidylethanolamine 91-115 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-46 11960751-1 2002 Phosphatidylethanolamine N-methyltransferase 2 (PEMT2) is an isoform of PEMT that converts phosphatidylethanolamine to phosphatidylcholine in mammalian liver. phosphatidylethanolamine 91-115 phosphatidylethanolamine N-methyltransferase Homo sapiens 48-53 11960751-1 2002 Phosphatidylethanolamine N-methyltransferase 2 (PEMT2) is an isoform of PEMT that converts phosphatidylethanolamine to phosphatidylcholine in mammalian liver. phosphatidylethanolamine 91-115 phosphatidylethanolamine N-methyltransferase Homo sapiens 48-52 11880242-1 2002 Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways. phosphatidylethanolamine 96-120 cut-like homeobox 1 Rattus norvegicus 140-143 11880242-1 2002 Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways. phosphatidylethanolamine 96-120 cut-like homeobox 1 Rattus norvegicus 156-159 11880242-1 2002 Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways. phosphatidylethanolamine 122-126 cut-like homeobox 1 Rattus norvegicus 140-143 11880242-1 2002 Choline and ethanolamine are substrates for de novo synthesis of phosphatidylcholine (PtdC) and phosphatidylethanolamine (PtdE) through the CDP-choline and CDP-ethanolamine pathways. phosphatidylethanolamine 122-126 cut-like homeobox 1 Rattus norvegicus 156-159 11880242-2 2002 In liver, PtdE can also be converted to PtdC by PtdE N-methyltransferase (PEMT). phosphatidylethanolamine 10-14 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 48-72 11880242-2 2002 In liver, PtdE can also be converted to PtdC by PtdE N-methyltransferase (PEMT). phosphatidylethanolamine 10-14 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 74-78 12186778-4 2002 Phosphatidylcholine and phosphatidylethanolamine, the major constituents of the mitochondrial inner membrane, stimulated purified Endo G activity 5- to 10-fold. phosphatidylethanolamine 24-48 endonuclease G Homo sapiens 130-136 12240034-1 2001 Phosphatidylethanolamine and -choline derivatives equipped with fluorescent donor-acceptor pairs of dyes connected to the tips of the fatty acids were synthesised and shown to be suitable substrates for phospholipase A2. phosphatidylethanolamine 0-24 phospholipase A2 group IB Homo sapiens 203-219 11689437-6 2001 Analysis of apg mutants revealed that the formation of both a phosphatidylethanolamine-conjugated Aut7p and an Apg12p- Apg5p conjugate is essential for the localization of Aut7p to the pre-autophagosomal structure. phosphatidylethanolamine 62-86 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 98-103 11689437-6 2001 Analysis of apg mutants revealed that the formation of both a phosphatidylethanolamine-conjugated Aut7p and an Apg12p- Apg5p conjugate is essential for the localization of Aut7p to the pre-autophagosomal structure. phosphatidylethanolamine 62-86 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 172-177 11712858-0 2001 Certain autoantibodies to phosphatidylethanolamine (aPE) recognize factor XI and prekallikrein independently or in addition to the kininogens. phosphatidylethanolamine 26-50 coagulation factor XI Homo sapiens 67-76 11712858-2 2001 We also reported that certain antiphosphatidylethanolamine antibodies (aPE) are not specific for phosphatidylethanolamine (PE) per se, but are directed to PE-binding plasma proteins, high molecular weight kininogen (HK), and low molecular weight kininogen (LK). phosphatidylethanolamine 34-58 kininogen 1 Homo sapiens 183-214 11712858-2 2001 We also reported that certain antiphosphatidylethanolamine antibodies (aPE) are not specific for phosphatidylethanolamine (PE) per se, but are directed to PE-binding plasma proteins, high molecular weight kininogen (HK), and low molecular weight kininogen (LK). phosphatidylethanolamine 72-74 kininogen 1 Homo sapiens 183-214 11758729-1 2001 The easily shocked (eas) gene of Drosophila melanogaster encodes ethanolamine kinase (EK), the first step in phosphatidylethanolamine (PE) synthesis via the CDP-ethanolamine pathway Flies mutant for eas display a complex neurological phenotype. phosphatidylethanolamine 109-133 easily shocked Drosophila melanogaster 4-18 11758729-1 2001 The easily shocked (eas) gene of Drosophila melanogaster encodes ethanolamine kinase (EK), the first step in phosphatidylethanolamine (PE) synthesis via the CDP-ethanolamine pathway Flies mutant for eas display a complex neurological phenotype. phosphatidylethanolamine 109-133 easily shocked Drosophila melanogaster 65-84 11758729-1 2001 The easily shocked (eas) gene of Drosophila melanogaster encodes ethanolamine kinase (EK), the first step in phosphatidylethanolamine (PE) synthesis via the CDP-ethanolamine pathway Flies mutant for eas display a complex neurological phenotype. phosphatidylethanolamine 109-133 easily shocked Drosophila melanogaster 86-88 11758729-1 2001 The easily shocked (eas) gene of Drosophila melanogaster encodes ethanolamine kinase (EK), the first step in phosphatidylethanolamine (PE) synthesis via the CDP-ethanolamine pathway Flies mutant for eas display a complex neurological phenotype. phosphatidylethanolamine 135-137 easily shocked Drosophila melanogaster 4-18 11758729-1 2001 The easily shocked (eas) gene of Drosophila melanogaster encodes ethanolamine kinase (EK), the first step in phosphatidylethanolamine (PE) synthesis via the CDP-ethanolamine pathway Flies mutant for eas display a complex neurological phenotype. phosphatidylethanolamine 135-137 easily shocked Drosophila melanogaster 65-84 11758729-1 2001 The easily shocked (eas) gene of Drosophila melanogaster encodes ethanolamine kinase (EK), the first step in phosphatidylethanolamine (PE) synthesis via the CDP-ethanolamine pathway Flies mutant for eas display a complex neurological phenotype. phosphatidylethanolamine 135-137 easily shocked Drosophila melanogaster 86-88 12111845-5 2002 Treatment of (3)H-AA-labeled cortical neurons with mildly toxic concentrations of sPLA(2) (25 ng/ml, 1.78 nM) for 45 min resulted in a two- to threefold higher loss of (3)H-AA from phosphatidylcholine (PC) than from phosphatidylethanolamine (PE) and in minor changes in other phospholipids. phosphatidylethanolamine 216-240 phospholipase A2 group IIA Homo sapiens 82-89 12111845-5 2002 Treatment of (3)H-AA-labeled cortical neurons with mildly toxic concentrations of sPLA(2) (25 ng/ml, 1.78 nM) for 45 min resulted in a two- to threefold higher loss of (3)H-AA from phosphatidylcholine (PC) than from phosphatidylethanolamine (PE) and in minor changes in other phospholipids. phosphatidylethanolamine 242-244 phospholipase A2 group IIA Homo sapiens 82-89 11988566-2 2002 We show that phosphatidylethanolamine, the major phospholipid in Drosophila, controls the release of sterol regulatory element-binding protein (SREBP) from Drosophila cell membranes, exerting feedback control on the synthesis of fatty acids and phospholipids. phosphatidylethanolamine 13-37 Sterol regulatory element binding protein Drosophila melanogaster 101-142 11988566-2 2002 We show that phosphatidylethanolamine, the major phospholipid in Drosophila, controls the release of sterol regulatory element-binding protein (SREBP) from Drosophila cell membranes, exerting feedback control on the synthesis of fatty acids and phospholipids. phosphatidylethanolamine 13-37 Sterol regulatory element binding protein Drosophila melanogaster 144-149 11988566-3 2002 The finding that SREBP processing is controlled by different lipids in mammals and flies (sterols and phosphatidylethanolamine, respectively) suggests that an essential function of SREBP is to monitor cell membrane composition and to adjust lipid synthesis accordingly. phosphatidylethanolamine 102-126 Sterol regulatory element binding protein Drosophila melanogaster 17-22 11988566-3 2002 The finding that SREBP processing is controlled by different lipids in mammals and flies (sterols and phosphatidylethanolamine, respectively) suggests that an essential function of SREBP is to monitor cell membrane composition and to adjust lipid synthesis accordingly. phosphatidylethanolamine 102-126 Sterol regulatory element binding protein Drosophila melanogaster 181-186 11829744-5 2002 The diminution of PE biosynthesis, however, was paralleled by a depressed activity of CTP:phosphoethanolamine cytidylyltransferase (ET), the pace-setting enzyme of the CDP-ethanolamine pathway. phosphatidylethanolamine 18-20 phosphate cytidylyltransferase 2, ethanolamine Rattus norvegicus 86-130 11829744-5 2002 The diminution of PE biosynthesis, however, was paralleled by a depressed activity of CTP:phosphoethanolamine cytidylyltransferase (ET), the pace-setting enzyme of the CDP-ethanolamine pathway. phosphatidylethanolamine 18-20 cut-like homeobox 1 Rattus norvegicus 168-171 12604051-3 2002 Here we report that (1) Doxil, HPL, pegylated phosphatidylethanolamine (PEG-PE)-containing empty liposomes matched with Doxil and HPL in size and lipid composition, and phosphatidylglycerol (PG)-containing negatively charged vesicles were potent C activators in human serum in vitro, whereas small neutral liposomes caused no C activation. phosphatidylethanolamine 46-70 progestagen associated endometrial protein Homo sapiens 72-75 11853019-2 2002 HCNP precursor protein (HCNP-pp) is known to interact with other molecules including phosphatidylethanolamine and Raf-1 kinase, and is also known as phosphatidylethanolamine-binding protein and raf kinase-inhibitory protein. phosphatidylethanolamine 85-109 phosphatidylethanolamine binding protein 1 Homo sapiens 0-22 11853019-2 2002 HCNP precursor protein (HCNP-pp) is known to interact with other molecules including phosphatidylethanolamine and Raf-1 kinase, and is also known as phosphatidylethanolamine-binding protein and raf kinase-inhibitory protein. phosphatidylethanolamine 85-109 phosphatidylethanolamine binding protein 1 Homo sapiens 0-4 11853019-2 2002 HCNP precursor protein (HCNP-pp) is known to interact with other molecules including phosphatidylethanolamine and Raf-1 kinase, and is also known as phosphatidylethanolamine-binding protein and raf kinase-inhibitory protein. phosphatidylethanolamine 149-173 phosphatidylethanolamine binding protein 1 Homo sapiens 0-22 11853019-2 2002 HCNP precursor protein (HCNP-pp) is known to interact with other molecules including phosphatidylethanolamine and Raf-1 kinase, and is also known as phosphatidylethanolamine-binding protein and raf kinase-inhibitory protein. phosphatidylethanolamine 149-173 phosphatidylethanolamine binding protein 1 Homo sapiens 0-4 11853019-2 2002 HCNP precursor protein (HCNP-pp) is known to interact with other molecules including phosphatidylethanolamine and Raf-1 kinase, and is also known as phosphatidylethanolamine-binding protein and raf kinase-inhibitory protein. phosphatidylethanolamine 149-173 phosphatidylethanolamine binding protein 1 Homo sapiens 194-223 11722570-5 2001 PEBP affinity for negatively charged membranes is puzzling considering the previous identification of the protein as a phosphatidylethanolamine-binding protein, and suggests that the association of PEBP with phospholipid membranes is driven by a mechanism other than its binding to solubilized phosphatidylethanolamine. phosphatidylethanolamine 119-143 phosphatidylethanolamine binding protein 1 Bos taurus 0-4 11602607-1 2001 Two yeast enzymes, Psd1p and Psd2p, catalyze the decarboxylation of phosphatidylserine to produce phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 98-122 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 29-34 11602607-1 2001 Two yeast enzymes, Psd1p and Psd2p, catalyze the decarboxylation of phosphatidylserine to produce phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 124-130 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 19-24 11602607-1 2001 Two yeast enzymes, Psd1p and Psd2p, catalyze the decarboxylation of phosphatidylserine to produce phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 124-130 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 29-34 11602607-8 2001 In contrast, a psd1Delta psd2Delta strain, which makes low levels of PtdEtn from sphingolipid breakdown, can be rescued by ethanolamine, choline, or the ethanolamine analogue propanolamine. phosphatidylethanolamine 69-75 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 15-19 11768161-6 2001 The c9,t11-CLA isomer decreased (P < 0.05) uptake of 14C-AA into phosphatidylcholine while increasing (P < 0.05) uptake into phosphatidylethanolamine in both cell lines. phosphatidylethanolamine 131-155 complement C9 Homo sapiens 4-14 11513612-7 2001 The Ca(2+)-dependent PKCalpha, PKCbeta, and PKCgamma, along with Ca(2+)-independent PKCdelta, but not PKCepsilon or PKCzeta, displayed a biphasic activity as a function of membrane PE content. phosphatidylethanolamine 181-183 protein kinase C alpha Homo sapiens 21-29 11566147-3 2001 The SAM-dependent methylation of phosphatidylethanolamine (PTE) to produce phosphatidylcholine (PTC), via phosphatidylethanolamine-N-methyltransferase (PEMT), and the hydrolysis of PTC to form lyso-PTC, a cytotoxic agent, are potential loci for the action of MPP(+). phosphatidylethanolamine 33-57 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 106-150 11566147-3 2001 The SAM-dependent methylation of phosphatidylethanolamine (PTE) to produce phosphatidylcholine (PTC), via phosphatidylethanolamine-N-methyltransferase (PEMT), and the hydrolysis of PTC to form lyso-PTC, a cytotoxic agent, are potential loci for the action of MPP(+). phosphatidylethanolamine 33-57 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 152-156 11566147-3 2001 The SAM-dependent methylation of phosphatidylethanolamine (PTE) to produce phosphatidylcholine (PTC), via phosphatidylethanolamine-N-methyltransferase (PEMT), and the hydrolysis of PTC to form lyso-PTC, a cytotoxic agent, are potential loci for the action of MPP(+). phosphatidylethanolamine 59-62 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 106-150 11566147-3 2001 The SAM-dependent methylation of phosphatidylethanolamine (PTE) to produce phosphatidylcholine (PTC), via phosphatidylethanolamine-N-methyltransferase (PEMT), and the hydrolysis of PTC to form lyso-PTC, a cytotoxic agent, are potential loci for the action of MPP(+). phosphatidylethanolamine 59-62 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 152-156 11513612-7 2001 The Ca(2+)-dependent PKCalpha, PKCbeta, and PKCgamma, along with Ca(2+)-independent PKCdelta, but not PKCepsilon or PKCzeta, displayed a biphasic activity as a function of membrane PE content. phosphatidylethanolamine 181-183 protein kinase C beta Homo sapiens 31-38 11513612-7 2001 The Ca(2+)-dependent PKCalpha, PKCbeta, and PKCgamma, along with Ca(2+)-independent PKCdelta, but not PKCepsilon or PKCzeta, displayed a biphasic activity as a function of membrane PE content. phosphatidylethanolamine 181-183 protein kinase C gamma Homo sapiens 44-52 11513612-7 2001 The Ca(2+)-dependent PKCalpha, PKCbeta, and PKCgamma, along with Ca(2+)-independent PKCdelta, but not PKCepsilon or PKCzeta, displayed a biphasic activity as a function of membrane PE content. phosphatidylethanolamine 181-183 protein kinase C delta Homo sapiens 84-92 11513612-9 2001 In addition, the rotational correlation time of both PKCalpha and PKCdelta C1-domain-associated sapintoxin D, a fluorescent phorbol ester, was also a biphasic function of membrane lipid PE content. phosphatidylethanolamine 186-188 protein kinase C alpha Homo sapiens 53-61 11513612-9 2001 In addition, the rotational correlation time of both PKCalpha and PKCdelta C1-domain-associated sapintoxin D, a fluorescent phorbol ester, was also a biphasic function of membrane lipid PE content. phosphatidylethanolamine 186-188 protein kinase C delta Homo sapiens 66-74 11551535-4 2001 PC-TP from the cytosol contains phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) with a preference for the di-monounsaturated species over the saturated species as determined by fast atom bombardment mass spectrometry (FAB-MS). phosphatidylethanolamine 32-56 phosphatidylcholine transfer protein Bos taurus 0-5 11551535-4 2001 PC-TP from the cytosol contains phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) with a preference for the di-monounsaturated species over the saturated species as determined by fast atom bombardment mass spectrometry (FAB-MS). phosphatidylethanolamine 58-60 phosphatidylcholine transfer protein Bos taurus 0-5 11441067-3 2001 However, in vitro SAP also can bind to phosphatidylethanolamine, a phospholipid which in normal cells is located mainly in the inner leaflet of the cell membrane, to be translocated to the outer leaflet of the cell membrane during a membrane flip-flop. phosphatidylethanolamine 39-63 amyloid P component, serum Homo sapiens 18-21 11441067-4 2001 We hypothesized that SAP, because of its specificity for phosphatidylethanolamine, may bind to apoptotic cells independent of its nuclear binding. phosphatidylethanolamine 57-81 amyloid P component, serum Homo sapiens 21-24 11441067-6 2001 Experiments with flip-flopped erythrocytes confirmed that SAP bound to early apoptotic cells via exposed phosphatidylethanolamine. phosphatidylethanolamine 105-129 amyloid P component, serum Homo sapiens 58-61 11442313-8 2001 Digestion of control SR with phospholipase A2 decreased [3H]ryanodine binding and the decrease was reversible by the addition of phosphatidylcholine (PC), phosphatidylethanolamine (PE), or phosphatidylserine (PS). phosphatidylethanolamine 181-183 phospholipase A2 group IB Rattus norvegicus 29-45 11470243-8 2001 Unexpectedly, abnormal phospholipids, phosphatidylcholine and phosphatidylethanolamine, both of which contain a very-long-chain fatty acyl residue (1-melissoyl-2-oleolyl-sn-glycero-3-phosphocholine and 1-melissoyl-2-oleolyl-sn-glycero-3-phosphoethanolamine), accumulated in fas2 strains in a temperature-sensitive manner. phosphatidylethanolamine 62-86 trifunctional fatty acid synthase subunit FAS2 Saccharomyces cerevisiae S288C 274-278 11294854-2 2001 Analysis of erythrocyte phospholipid metabolism by thin-layer chromatography revealed significant hydrolysis of both phosphatidylcholine and phosphatidylethanolamine during incubation with ionomycin and sPLA(2). phosphatidylethanolamine 141-165 phospholipase A2 group X Homo sapiens 203-210 11389609-6 2001 P-Glycoprotein exhibited a broad specificity for phospholipids, and translocated phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin. phosphatidylethanolamine 102-126 ATP binding cassette subfamily B member 1 Homo sapiens 0-14 11180458-9 2001 It can be envisaged that phosphatidylethanolamine might play a role in this process or in the early steps of the secretion pathway common for all amino acid permeases or, eventually, it could affect the transport proteins directly at the plasma membrane Transformation of the triple mutant with a CEN plasmid harbouring BST1 wild-type gene totally reversed its phenotype to that observed in the double mutant. phosphatidylethanolamine 25-49 Bst1p Saccharomyces cerevisiae S288C 320-324 11118436-9 2001 The results of TLC overlay assay for the binding of (125)I-SVS VII to phospholipids and the interaction between SVS VII and phospholipid liposomes demonstrated a specific binding of this protein to both phosphatidylethanolamine and phosphatidylserine. phosphatidylethanolamine 203-227 prostate and testis expressed 4 Mus musculus 59-66 11118436-9 2001 The results of TLC overlay assay for the binding of (125)I-SVS VII to phospholipids and the interaction between SVS VII and phospholipid liposomes demonstrated a specific binding of this protein to both phosphatidylethanolamine and phosphatidylserine. phosphatidylethanolamine 203-227 prostate and testis expressed 4 Mus musculus 112-119 11256474-5 2001 On the other hand, dextran sulfate and phosphatidylethanolamine enhanced the auto-fragmentation and the serine protease activity of pro-PHBP, but kaolin did not. phosphatidylethanolamine 39-63 hyaluronan binding protein 2 Homo sapiens 136-140 11251067-3 2001 EPT1-derived activity can transfer either phosphocholine or phosphoethanolamine to diacylglcyerol in vitro, but is currently believed to primarily synthesize phosphatidylethanolamine in vivo. phosphatidylethanolamine 158-182 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 0-4 11282244-6 2001 The increase in degradation may be due to an improvement of the substrate - as it is well known, that PE is a better substrate for the mammalian sPLA(2) than PC. phosphatidylethanolamine 102-104 phospholipase A2 group IIA Homo sapiens 145-152 11282244-7 2001 Incorporation of PE into the bilayer may increase the binding properties of the bilayer resulting in improved conditions for the enzymatic attack by sPLA(2). phosphatidylethanolamine 17-19 phospholipase A2 group IIA Homo sapiens 149-156 11044440-5 2000 Using CD, we demonstrate that a peptide, corresponding to the N-terminal 18 residues of IIA(Glc), adopts a helical conformation in the presence of either the anionic lipid phosphatidylglycerol or a mixture of anionic E. coli lipids phosphatidylglycerol (25%) and phosphatidylethanolamine (75%). phosphatidylethanolamine 263-287 colicin Ia immunity protein Escherichia coli 88-96 10915790-3 2000 alpha-Syn was found to bind to acidic phospholipid vesicles and this binding was significantly augmented by the presence of phosphatidylethanolamine, a neutral phospholipid. phosphatidylethanolamine 124-148 synuclein alpha Homo sapiens 0-9 11139573-3 2001 Apg12p is then transferred to Apg10p, an E2-like enzyme, and conjugated with Apg5p, whereas Apg8p is transferred to Apg3p, another E2-like enzyme, followed by conjugation with phosphatidylethanolamine. phosphatidylethanolamine 176-200 Atg12p Saccharomyces cerevisiae S288C 0-6 11139573-3 2001 Apg12p is then transferred to Apg10p, an E2-like enzyme, and conjugated with Apg5p, whereas Apg8p is transferred to Apg3p, another E2-like enzyme, followed by conjugation with phosphatidylethanolamine. phosphatidylethanolamine 176-200 E2-like conjugating enzyme Saccharomyces cerevisiae S288C 30-36 11139573-3 2001 Apg12p is then transferred to Apg10p, an E2-like enzyme, and conjugated with Apg5p, whereas Apg8p is transferred to Apg3p, another E2-like enzyme, followed by conjugation with phosphatidylethanolamine. phosphatidylethanolamine 176-200 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 92-97 11084049-1 2001 In mammalian cells, phosphatidylserine is synthesized by two different enzymes, phosphatidylserine synthase (PSS)-1 and -2, via a base exchange reaction in which the head group of a phospholipid (phosphatidylcholine or phosphatidylethanolamine) is replaced by l-serine. phosphatidylethanolamine 219-243 phosphatidylserine synthase 1 Homo sapiens 80-122 11282244-9 2001 In conclusion, this study suggest that degradation of the lipid bilayer of PEG-liposomes by PLA(2) result in release of incapsulated drug, e.g. gentamicin and inclusion of PE in the liposomal bilayer, may enhance the activity of the mammalian sPLA(2) toward liposomes composed of DPPC. phosphatidylethanolamine 75-77 phospholipase A2 group IB Homo sapiens 92-98 11282244-9 2001 In conclusion, this study suggest that degradation of the lipid bilayer of PEG-liposomes by PLA(2) result in release of incapsulated drug, e.g. gentamicin and inclusion of PE in the liposomal bilayer, may enhance the activity of the mammalian sPLA(2) toward liposomes composed of DPPC. phosphatidylethanolamine 75-77 phospholipase A2 group IIA Homo sapiens 243-250 11044454-1 2001 Ethanolamine kinase (EKI) is the first committed step in phosphatidylethanolamine (PtdEtn) biosynthesis via the CDP-ethanolamine pathway. phosphatidylethanolamine 57-81 choline kinase alpha Homo sapiens 0-19 11044454-1 2001 Ethanolamine kinase (EKI) is the first committed step in phosphatidylethanolamine (PtdEtn) biosynthesis via the CDP-ethanolamine pathway. phosphatidylethanolamine 57-81 choline kinase alpha Homo sapiens 21-24 11044454-1 2001 Ethanolamine kinase (EKI) is the first committed step in phosphatidylethanolamine (PtdEtn) biosynthesis via the CDP-ethanolamine pathway. phosphatidylethanolamine 57-81 cut like homeobox 1 Homo sapiens 112-115 11044454-1 2001 Ethanolamine kinase (EKI) is the first committed step in phosphatidylethanolamine (PtdEtn) biosynthesis via the CDP-ethanolamine pathway. phosphatidylethanolamine 83-89 choline kinase alpha Homo sapiens 0-19 11044454-1 2001 Ethanolamine kinase (EKI) is the first committed step in phosphatidylethanolamine (PtdEtn) biosynthesis via the CDP-ethanolamine pathway. phosphatidylethanolamine 83-89 choline kinase alpha Homo sapiens 21-24 11044454-1 2001 Ethanolamine kinase (EKI) is the first committed step in phosphatidylethanolamine (PtdEtn) biosynthesis via the CDP-ethanolamine pathway. phosphatidylethanolamine 83-89 cut like homeobox 1 Homo sapiens 112-115 11044454-3 2001 EKI1 overexpression in COS-7 cells results in a 170-fold increase in ethanolamine kinase-specific activity and accelerates the rate of [3H]ethanolamine incorporation into PtdEtn as a function of the ethanolamine concentration in the culture medium. phosphatidylethanolamine 171-177 ethanolamine kinase 1 Homo sapiens 0-4 11044454-4 2001 Acceleration of the CDP-ethanolamine pathway does not result in elevated cellular PtdEtn levels, but rather the excess PtdEtn is degraded to glycerophosphoethanolamine. phosphatidylethanolamine 119-125 cut like homeobox 1 Homo sapiens 20-23 11044454-7 2001 The data demonstrate the existence of separate ethanolamine and choline kinases in mammals and show that ethanolamine kinase can be a rate-controlling step in PtdEtn biosynthesis. phosphatidylethanolamine 159-165 choline kinase alpha Homo sapiens 105-124 11191643-2 2000 To overcome the rapid degradation of peptides in the circulation, an RGD mimetic, L-arginyl-6-aminohexanoic acid (NOK), was synthesized and conjugated with phosphatidylethanolamine (PE) (NOK-PE) for liposomalization. phosphatidylethanolamine 156-180 serine/threonine/tyrosine kinase 1 Mus musculus 114-117 11191643-2 2000 To overcome the rapid degradation of peptides in the circulation, an RGD mimetic, L-arginyl-6-aminohexanoic acid (NOK), was synthesized and conjugated with phosphatidylethanolamine (PE) (NOK-PE) for liposomalization. phosphatidylethanolamine 156-180 serine/threonine/tyrosine kinase 1 Mus musculus 187-190 11191643-2 2000 To overcome the rapid degradation of peptides in the circulation, an RGD mimetic, L-arginyl-6-aminohexanoic acid (NOK), was synthesized and conjugated with phosphatidylethanolamine (PE) (NOK-PE) for liposomalization. phosphatidylethanolamine 182-184 serine/threonine/tyrosine kinase 1 Mus musculus 114-117 11100732-6 2000 Apg8 is covalently conjugated to phosphatidylethanolamine through an amide bond between the C-terminal glycine and the amino group of phosphatidylethanolamine. phosphatidylethanolamine 33-57 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 0-4 11100732-6 2000 Apg8 is covalently conjugated to phosphatidylethanolamine through an amide bond between the C-terminal glycine and the amino group of phosphatidylethanolamine. phosphatidylethanolamine 134-158 ubiquitin-like protein ATG8 Saccharomyces cerevisiae S288C 0-4 10903316-8 2000 Consistently, in vitro biomolecular interaction between PS/phosphatidylethanolamine /phosphatidylcholine liposomes, and Raf-1 increased in a PS concentration-dependent manner. phosphatidylethanolamine 59-83 v-raf-leukemia viral oncogene 1 Mus musculus 120-125 11009606-3 2000 Both recombinant human heart BDH (HH-Histag-BDH) and GST-CTBDH (but not GST) form well-defined protein-lipid complexes with either PC or phosphatidylethanolamine (PE)/diphosphatidylglycerol (DPG) vesicles (but not with digalactosyl diglyceride vesicles) as demonstrated by flotation in sucrose gradients. phosphatidylethanolamine 137-161 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 29-32 11052824-4 2000 PC, PE and Chol demonstrated marked downregulation of TNF-alpha production at lipid concentrations of 125 and 250 microg/ml. phosphatidylethanolamine 4-6 tumor necrosis factor Homo sapiens 54-63 11052674-3 2000 Phospholipid vesicles composed of PE, phosphatidylserine (PS), and phosphatidylcholine support factor Xa generation. phosphatidylethanolamine 34-36 coagulation factor X Homo sapiens 95-104 11009606-3 2000 Both recombinant human heart BDH (HH-Histag-BDH) and GST-CTBDH (but not GST) form well-defined protein-lipid complexes with either PC or phosphatidylethanolamine (PE)/diphosphatidylglycerol (DPG) vesicles (but not with digalactosyl diglyceride vesicles) as demonstrated by flotation in sucrose gradients. phosphatidylethanolamine 137-161 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 34-47 11009606-3 2000 Both recombinant human heart BDH (HH-Histag-BDH) and GST-CTBDH (but not GST) form well-defined protein-lipid complexes with either PC or phosphatidylethanolamine (PE)/diphosphatidylglycerol (DPG) vesicles (but not with digalactosyl diglyceride vesicles) as demonstrated by flotation in sucrose gradients. phosphatidylethanolamine 163-165 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 29-32 11009606-3 2000 Both recombinant human heart BDH (HH-Histag-BDH) and GST-CTBDH (but not GST) form well-defined protein-lipid complexes with either PC or phosphatidylethanolamine (PE)/diphosphatidylglycerol (DPG) vesicles (but not with digalactosyl diglyceride vesicles) as demonstrated by flotation in sucrose gradients. phosphatidylethanolamine 163-165 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 34-47 11009606-8 2000 The analogous pyrenyl-PE effects a similar maximal quenching of tryptophan fluorescence for both proteins but with approximately 15-fold lower (K(Q))(eff) (half-maximal quenching at approximately 1.5% pyrenyl-PE) referable to nonspecific interaction of pyrenyl-PE with HH-Histag-BDH or GST-CTBDH. phosphatidylethanolamine 21-24 3-hydroxybutyrate dehydrogenase 1 Homo sapiens 269-282 10974061-10 2000 For example, 98;-99% precipitation of phosphatidylethanolamine, phosphatidylglycerol, and phosphatidylserine was achieved.Consequently, this new assay allows for a convenient examination of PLD activities toward a variety of phospholipid substrates, and in particular allows for the analysis of NAE formation from NAPE in vitro, a feature that will facilitate a more complete biochemical characterization of this anandamide-generating enzyme. phosphatidylethanolamine 38-62 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 190-193 11003606-6 2000 SCP-2 also enhanced microsomal acyl-chain remodeling of phosphatidylethanolamine up to fivefold and phosphatidylserine twofold, depending on the specific fatty acyl-CoA, but had no effect on other phospholipid classes. phosphatidylethanolamine 56-80 sterol carrier protein 2 Homo sapiens 0-5 10827200-7 2000 Analysis of molecular species of microsomal phosphatidylcholine and phosphatidylethanolamine by electron spray tandem mass spectrometry revealed that the enrichment of oleoyl moieties was altered by the treatment of iPLA(2) antagonist. phosphatidylethanolamine 68-92 phospholipase A2 group VI Rattus norvegicus 216-223 11200440-15 2000 The main changes of the PUFA were found to occur in phosphatidylethanolamine isolated from microsomes. phosphatidylethanolamine 52-76 pumilio RNA binding family member 3 Homo sapiens 24-28 10922994-2 2000 We analyzed the ability of muramyl tripeptide phosphatidylethanolamine (MTP-PE), an immunomodulatory bacterial cell wall analog, to stimulate Kupffer cells (KCs) and protect against tumor growth, with or without an immunosuppressive partial hepatectomy (PH). phosphatidylethanolamine 46-70 metallothionein 1B Homo sapiens 72-75 11200440-16 2000 The particular role of phosphatidylethanolamine and arachidonic acid in the reparation of membranes under the action of phospholipids PUFA omega-3 and alpha-tocopherol was noted. phosphatidylethanolamine 23-47 pumilio RNA binding family member 3 Homo sapiens 134-138 10533050-6 1999 This effect was specific to PC and thus resulted in a twofold decrease of the PC to phosphatidylethanolamine (PE) ratio in apoE-deficient mice compared to the corresponding control ratio. phosphatidylethanolamine 84-108 apolipoprotein E Mus musculus 123-127 10856718-7 2000 Three other ABC transporters were recently shown to be involved in lipid transport: ABCR, also called Rim protein, was shown to be defective in Stargardt"s macular dystrophy; this protein probably transports a complex of retinaldehyde and phosphatidylethanolamine in the retina of the eye. phosphatidylethanolamine 239-263 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 12-15 10856718-7 2000 Three other ABC transporters were recently shown to be involved in lipid transport: ABCR, also called Rim protein, was shown to be defective in Stargardt"s macular dystrophy; this protein probably transports a complex of retinaldehyde and phosphatidylethanolamine in the retina of the eye. phosphatidylethanolamine 239-263 ATP binding cassette subfamily A member 4 Homo sapiens 84-88 10856718-7 2000 Three other ABC transporters were recently shown to be involved in lipid transport: ABCR, also called Rim protein, was shown to be defective in Stargardt"s macular dystrophy; this protein probably transports a complex of retinaldehyde and phosphatidylethanolamine in the retina of the eye. phosphatidylethanolamine 239-263 ATP binding cassette subfamily A member 4 Homo sapiens 102-113 10852960-11 2000 USA (1998) 95, 14609-14613], for the biosynthesis of A2E: (i) condensation of all-trans-retinaldehyde (all-trans-RAL) with phosphatidylethanolamine to form a Schiff base; (ii) condensation of the amine product with a second all-trans-RAL to form a bis-retinoid; (iii) oxidation to yield a pyridinium salt; and (iv) hydrolysis of the phosphate ester to yield A2E. phosphatidylethanolamine 123-147 v-ral simian leukemia viral oncogene A (ras related) Mus musculus 113-116 10852960-11 2000 USA (1998) 95, 14609-14613], for the biosynthesis of A2E: (i) condensation of all-trans-retinaldehyde (all-trans-RAL) with phosphatidylethanolamine to form a Schiff base; (ii) condensation of the amine product with a second all-trans-RAL to form a bis-retinoid; (iii) oxidation to yield a pyridinium salt; and (iv) hydrolysis of the phosphate ester to yield A2E. phosphatidylethanolamine 123-147 v-ral simian leukemia viral oncogene A (ras related) Mus musculus 234-237 10827979-6 2000 The data suggest that the lipid phosphate groups of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) in PC/PE/PS (4:4:1, mol/mol) are primary targets for Ca(2+). phosphatidylethanolamine 78-102 procollagen C-endopeptidase enhancer Homo sapiens 140-148 10827979-6 2000 The data suggest that the lipid phosphate groups of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylserine (PS) in PC/PE/PS (4:4:1, mol/mol) are primary targets for Ca(2+). phosphatidylethanolamine 104-106 procollagen C-endopeptidase enhancer Homo sapiens 140-148 10827979-10 2000 However, depending on temperature and hydrocarbon chain unsaturation, the lipid with the highest chain melting temperature converted to the gel state, as observed for the monounsaturated phosphatidylethanolamine (PE) in PC/PE/PS (4:4:1, mol/mol) at 25 degrees C. phosphatidylethanolamine 187-211 procollagen C-endopeptidase enhancer Homo sapiens 220-228 10827979-10 2000 However, depending on temperature and hydrocarbon chain unsaturation, the lipid with the highest chain melting temperature converted to the gel state, as observed for the monounsaturated phosphatidylethanolamine (PE) in PC/PE/PS (4:4:1, mol/mol) at 25 degrees C. phosphatidylethanolamine 213-215 procollagen C-endopeptidase enhancer Homo sapiens 220-228 10865135-1 2000 Stimulation of the aminophospholipid translocase, responsible for the transport of phosphatidylserine and phosphatidylethanolamine from the outer to the inner leaflet of the plasma membrane, provokes endocytic-like vesicles in erythrocytes and stimulates endocytosis in K562 cells. phosphatidylethanolamine 106-130 ATPase phospholipid transporting 8A1 Homo sapiens 19-48 10760824-1 2000 Phosphatidylethanolamine N-methyltransferase(PEMT) is an enzyme in liver that catalyzes the stepwise methylation of phosphatidylethanolamine to phosphatidylcholine, in addition to the main pathway that synthesizes phosphatidylcholine directly from choline. phosphatidylethanolamine 116-140 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 45-49 10744670-6 2000 Activated human neutrophils generated pHA-ethanolamine, the reduced adduct of pHA with the amino group of phosphatidylethanolamine, on LDL phospholipids by a reaction that required myeloperoxidase, H(2)O(2), and L-tyrosine. phosphatidylethanolamine 106-130 lamin B receptor Homo sapiens 38-41 10744670-6 2000 Activated human neutrophils generated pHA-ethanolamine, the reduced adduct of pHA with the amino group of phosphatidylethanolamine, on LDL phospholipids by a reaction that required myeloperoxidase, H(2)O(2), and L-tyrosine. phosphatidylethanolamine 106-130 myeloperoxidase Homo sapiens 181-196 10706593-1 2000 Choline/ethanolamine kinase (CK/EK) is the first enzyme in phosphatidylcholine/phosphatidylethanolamine biosynthesis in all animal cells. phosphatidylethanolamine 79-103 choline kinase beta Mus musculus 0-27 10706593-1 2000 Choline/ethanolamine kinase (CK/EK) is the first enzyme in phosphatidylcholine/phosphatidylethanolamine biosynthesis in all animal cells. phosphatidylethanolamine 79-103 choline kinase beta Mus musculus 29-34 10751643-4 2000 Supplementation of THP-1 with AA (25 microM, 1 week) or EPA (25 microM, 1 week) led to their efficient incorporation, in comparable quantities and with similar distributions, into phosphatidylcholine and phosphatidylethanolamine, and to a lesser extent into phosphatidylinositol. phosphatidylethanolamine 204-228 GLI family zinc finger 2 Homo sapiens 19-24 10653794-8 2000 GALA-induced ANTS/DPX leakage is also decreased when the vesicles contain phosphatidylethanolamine (PE). phosphatidylethanolamine 74-98 galactosidase alpha Homo sapiens 0-4 10926375-3 2000 For membranes formed in squalene, the values etar approximately 10(-7) g/s for phosphatidylethanolamine and etar approximately 2-10(-7) g/s for azolectin were obtained. phosphatidylethanolamine 79-103 endothelin receptor type A Homo sapiens 45-49 10622376-7 2000 The 21 kDa HCNP precursor protein shows homology with other proteins, and it functions not only as an HCNP precursor, but also as a binding protein for ATP, opioids and phosphatidylethanolamine. phosphatidylethanolamine 169-193 phosphatidylethanolamine binding protein 1 Homo sapiens 11-15 10567228-8 1999 Increasing the cholesterol concentration, the phosphatidylethanolamine concentration, the sn-2 unsaturation in phosphatidylcholine and the vesicle curvature each also elevated SAPD-induced PKC activity and again increased the PKC-associated SAPD rotational correlation time. phosphatidylethanolamine 46-70 protein kinase C alpha Homo sapiens 189-192 10938271-3 2000 Taking advantage of the substrate specificity of PSS1, we showed that (i) MAM contain choline exchange activity, whereas this activity is very low in the bulk of the ER, (ii) serine exchange activity is inhibited by choline to a much greater extent in MAM than in ER, and (iii) MAM use phosphatidylcholine and phosphatidylethanolamine as substrates for phosphatidylserine biosynthesis, whereas the ER utilizes only phosphatidylethanolamine. phosphatidylethanolamine 310-334 phosphatidylserine synthase 1 Cricetulus griseus 49-53 10938271-3 2000 Taking advantage of the substrate specificity of PSS1, we showed that (i) MAM contain choline exchange activity, whereas this activity is very low in the bulk of the ER, (ii) serine exchange activity is inhibited by choline to a much greater extent in MAM than in ER, and (iii) MAM use phosphatidylcholine and phosphatidylethanolamine as substrates for phosphatidylserine biosynthesis, whereas the ER utilizes only phosphatidylethanolamine. phosphatidylethanolamine 415-439 phosphatidylserine synthase 1 Cricetulus griseus 49-53 10775457-0 2000 Protein kinase C-stimulated formation of ethanolamine from phosphatidylethanolamine involves a protein phosphorylation mechanism: negative regulation by p21 Ras protein. phosphatidylethanolamine 59-83 HRas proto-oncogene, GTPase Homo sapiens 153-160 10775457-1 2000 Mammalian cells express a phospholipase D (PLD)-like enzyme which forms ethanolamine from phosphatidylethanolamine (PtdEtn) by a protein kinase C-alpha (PKC-alpha)-activated, presently unknown, mechanism. phosphatidylethanolamine 90-114 protein kinase C alpha Homo sapiens 153-162 10775457-1 2000 Mammalian cells express a phospholipase D (PLD)-like enzyme which forms ethanolamine from phosphatidylethanolamine (PtdEtn) by a protein kinase C-alpha (PKC-alpha)-activated, presently unknown, mechanism. phosphatidylethanolamine 116-122 protein kinase C alpha Homo sapiens 153-162 10775457-2 2000 Now we report that addition of a PKC-alpha-enriched purified PKC preparation or recombinant PKC-alpha to a plasma membrane-enriched membrane fraction, isolated from leukemic HL60 cells, greatly ( approximately 6.5-fold stimulation) enhanced PtdEtn hydrolysis if the PKC activator phorbol 12-myristate 13-acetate (PMA) and ATP were both present; this was accompanied by PKC-mediated phosphorylation of several membrane proteins. phosphatidylethanolamine 241-247 protein kinase C alpha Homo sapiens 33-42 10775457-2 2000 Now we report that addition of a PKC-alpha-enriched purified PKC preparation or recombinant PKC-alpha to a plasma membrane-enriched membrane fraction, isolated from leukemic HL60 cells, greatly ( approximately 6.5-fold stimulation) enhanced PtdEtn hydrolysis if the PKC activator phorbol 12-myristate 13-acetate (PMA) and ATP were both present; this was accompanied by PKC-mediated phosphorylation of several membrane proteins. phosphatidylethanolamine 241-247 protein kinase C alpha Homo sapiens 33-36 10775457-2 2000 Now we report that addition of a PKC-alpha-enriched purified PKC preparation or recombinant PKC-alpha to a plasma membrane-enriched membrane fraction, isolated from leukemic HL60 cells, greatly ( approximately 6.5-fold stimulation) enhanced PtdEtn hydrolysis if the PKC activator phorbol 12-myristate 13-acetate (PMA) and ATP were both present; this was accompanied by PKC-mediated phosphorylation of several membrane proteins. phosphatidylethanolamine 241-247 protein kinase C alpha Homo sapiens 92-101 10775457-2 2000 Now we report that addition of a PKC-alpha-enriched purified PKC preparation or recombinant PKC-alpha to a plasma membrane-enriched membrane fraction, isolated from leukemic HL60 cells, greatly ( approximately 6.5-fold stimulation) enhanced PtdEtn hydrolysis if the PKC activator phorbol 12-myristate 13-acetate (PMA) and ATP were both present; this was accompanied by PKC-mediated phosphorylation of several membrane proteins. phosphatidylethanolamine 241-247 protein kinase C alpha Homo sapiens 61-64 10772808-7 2000 Incubation of P19 cells with the phosphatidylethanolamine biosynthesis inhibitor 8-(4-chlorophenylthio)-cAMP inhibited the differentiation-induced elevation in phosphatidylethanolamine levels but did not affect the expression of striated myosin. phosphatidylethanolamine 33-57 myosin heavy chain 14 Homo sapiens 238-244 10752579-5 2000 In contrast, the activity of phosphoethanolamine cytidylyltransferase (PECT), the rate-limiting enzyme of phosphatidylethanolamine synthesis, was significantly and markedly decreased by 35%-78% in the cerebellar, frontal, and occipital cortices of patients with FA but was normal in SCA-1. phosphatidylethanolamine 106-130 ataxin 1 Homo sapiens 283-288 10653794-8 2000 GALA-induced ANTS/DPX leakage is also decreased when the vesicles contain phosphatidylethanolamine (PE). phosphatidylethanolamine 100-102 galactosidase alpha Homo sapiens 0-4 10533050-6 1999 This effect was specific to PC and thus resulted in a twofold decrease of the PC to phosphatidylethanolamine (PE) ratio in apoE-deficient mice compared to the corresponding control ratio. phosphatidylethanolamine 110-112 apolipoprotein E Mus musculus 123-127 11015572-1 1999 The aminophospholipid translocase transports phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. phosphatidylethanolamine 68-92 ATPase, class I, type 8B, member 1 Mus musculus 4-33 10548476-1 1999 Phosphatidylethanolamine N-Methyltransferase (PE N-MTase) is the enzyme responsible for the synthesis of phosphatidylcholine from phosphatidylethanolamine by successive transfer of methyl groups. phosphatidylethanolamine 130-154 phosphatidylethanolamine N-methyltransferase Bos taurus 0-44 10548476-1 1999 Phosphatidylethanolamine N-Methyltransferase (PE N-MTase) is the enzyme responsible for the synthesis of phosphatidylcholine from phosphatidylethanolamine by successive transfer of methyl groups. phosphatidylethanolamine 130-154 phosphatidylethanolamine N-methyltransferase Bos taurus 46-56 10783747-5 1999 Phosphatidylcholine, phosphatidylethanolamine and cardiolipin were decreased significantly by 40%, 49% and 60% respectively in CCl4 treated rats. phosphatidylethanolamine 21-45 C-C motif chemokine ligand 4 Rattus norvegicus 127-131 10320809-8 1999 In the sn-1 to -2 transfer, the sn-1 acyl residue of 1-acyl-sn-glycero-3-phosphocholine was transferred to not only the sn-2 positions of 1-acyl-sn-glycero-3-phosphocholine, but also 1-acyl-sn-glycero-3-phosphoethanolamine, producing phosphatidylcholine and phosphatidylethanolamine, respectively. phosphatidylethanolamine 258-282 heterogeneous nuclear ribonucleoprotein U Rattus norvegicus 7-17 10523605-4 1999 The CD1d molecules can also bind both to the nonantigenic beta-GalCer and to phosphatidylethanolamine, indicating that diverse lipids can bind to CD1d. phosphatidylethanolamine 77-101 CD1d molecule Homo sapiens 4-8 10523605-4 1999 The CD1d molecules can also bind both to the nonantigenic beta-GalCer and to phosphatidylethanolamine, indicating that diverse lipids can bind to CD1d. phosphatidylethanolamine 77-101 CD1d molecule Homo sapiens 146-150 10524684-5 1999 It bound to prothrombin with low affinity, reacted with 3 phospholipids (cardiolipin, phosphatidylethanolamine, and phosphatidylserine), and showed lupus anticoagulant activity. phosphatidylethanolamine 86-110 coagulation factor II, thrombin Homo sapiens 12-23 10432300-1 1999 Phosphatidylserine (PtdSer) is synthesized in mammalian cells by two base-exchange enzymes: PtdSer synthase (PSS)-1 primarily uses phosphatidylcholine as a substrate for exchange with serine, whereas PSS2 uses phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 210-234 phosphatidylserine synthase 1 Homo sapiens 92-115 10432300-1 1999 Phosphatidylserine (PtdSer) is synthesized in mammalian cells by two base-exchange enzymes: PtdSer synthase (PSS)-1 primarily uses phosphatidylcholine as a substrate for exchange with serine, whereas PSS2 uses phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 236-242 phosphatidylserine synthase 1 Homo sapiens 92-115 10432300-3 1999 The activity of PSS1 in vitro and the synthesis of PtdSer and PtdSer-derived PtdEtn were increased, whereas PtdEtn synthesis from the CDP-ethanolamine pathway was inhibited [Stone, Cui and Vance (1998) J. Biol. phosphatidylethanolamine 77-83 phosphatidylserine synthase 1 Mus musculus 16-20 10419523-2 1999 The rate of PLCdelta1 hydrolysis of phosphatidylinositol 4,5-bisphosphate was stimulated 20-fold by phosphatidylserine (PS), 4-fold by phosphatidic acid (PA), and not at all by phosphatidylethanolamine or phosphatidylcholine (PC). phosphatidylethanolamine 177-201 phospholipase C delta 1 Homo sapiens 12-21 10413522-1 1999 Rotational diffusion measurements using EPR and saturation transfer EPR were applied to analyze complex formation between the electron-transfer components of the mitochondrial steroid-hydroxylating cytochrome P450 systems (CYP11A1 and CYP11B1) in phosphatidylcholine/phosphatidylethanolamine/cardiolipin vesicles prepared by octyl glucoside dialysis/adsorption. phosphatidylethanolamine 267-291 cytochrome P450 family 11 subfamily A member 1 Homo sapiens 223-230 10413522-1 1999 Rotational diffusion measurements using EPR and saturation transfer EPR were applied to analyze complex formation between the electron-transfer components of the mitochondrial steroid-hydroxylating cytochrome P450 systems (CYP11A1 and CYP11B1) in phosphatidylcholine/phosphatidylethanolamine/cardiolipin vesicles prepared by octyl glucoside dialysis/adsorption. phosphatidylethanolamine 267-291 cytochrome P450 family 11 subfamily B member 1 Homo sapiens 235-242 10395737-5 1999 For example, the catalytic efficiency (kcat/Km) of hGSTA1-1 for phosphatidylcholine (PC) hydroperoxide and phosphatidylethanolamine (PE) hydroperoxide was found to be 181.3 and 199.6 s-1 mM-1, respectively, while the catalytic efficiency of hGSTA2-2 for PC-hydroperoxide and PE-hydroperoxide was 317.5 and 353 s-1 mM-1, respectively. phosphatidylethanolamine 107-131 glutathione S-transferase alpha 1 Homo sapiens 51-59 10395737-5 1999 For example, the catalytic efficiency (kcat/Km) of hGSTA1-1 for phosphatidylcholine (PC) hydroperoxide and phosphatidylethanolamine (PE) hydroperoxide was found to be 181.3 and 199.6 s-1 mM-1, respectively, while the catalytic efficiency of hGSTA2-2 for PC-hydroperoxide and PE-hydroperoxide was 317.5 and 353 s-1 mM-1, respectively. phosphatidylethanolamine 133-135 glutathione S-transferase alpha 1 Homo sapiens 51-59 10395737-5 1999 For example, the catalytic efficiency (kcat/Km) of hGSTA1-1 for phosphatidylcholine (PC) hydroperoxide and phosphatidylethanolamine (PE) hydroperoxide was found to be 181.3 and 199.6 s-1 mM-1, respectively, while the catalytic efficiency of hGSTA2-2 for PC-hydroperoxide and PE-hydroperoxide was 317.5 and 353 s-1 mM-1, respectively. phosphatidylethanolamine 133-135 glutathione S-transferase alpha 2 Homo sapiens 241-249 10540966-7 1999 Treatment of PHX-exposed erythrocyte with bee venom phospholipase A2 induces the translocation of phosphatidylserine (PS) and phosphatidylethanolamine (PE) to the outer surface of the cell membrane. phosphatidylethanolamine 126-150 phospholipase A2 group IB Homo sapiens 52-68 10540966-7 1999 Treatment of PHX-exposed erythrocyte with bee venom phospholipase A2 induces the translocation of phosphatidylserine (PS) and phosphatidylethanolamine (PE) to the outer surface of the cell membrane. phosphatidylethanolamine 152-154 phospholipase A2 group IB Homo sapiens 52-68 10347212-3 1999 This study reports that glucosylated phosphatidylethanolamine (Glc-PtdEtn), the major LDL lipid glycation product, promotes LDL uptake and cholesteryl ester (CE) and triacylglycerol (TG) accumulation by THP-1 macrophages. phosphatidylethanolamine 37-61 GLI family zinc finger 2 Homo sapiens 203-208 10336610-2 1999 PLC-delta3 bound weakly to vesicles composed of phosphatidylcholine (PtdCho) or PtdCho plus phosphatidylethanolamine (PtdEtn) or phosphatidylinositol (PtdIns). phosphatidylethanolamine 92-116 phospholipase C delta 3 Homo sapiens 0-10 10336610-2 1999 PLC-delta3 bound weakly to vesicles composed of phosphatidylcholine (PtdCho) or PtdCho plus phosphatidylethanolamine (PtdEtn) or phosphatidylinositol (PtdIns). phosphatidylethanolamine 118-124 phospholipase C delta 3 Homo sapiens 0-10 10493918-1 1999 CTP:phosphoethanolamine cytidylyltransferase (ET) is a key regulatory enzyme in the CDP-ethanolamine pathway for phosphatidylethanolamine synthesis. phosphatidylethanolamine 113-137 phosphate cytidylyltransferase 2, ethanolamine Rattus norvegicus 0-44 10500152-4 1999 Exposure of phosphatidylserine and phosphatidylethanolamine on platelets, as determined by an increase in annexin V binding, was strongly stimulated by SFLLRN, thrombin, and collagen, but only to a minor extent by GYPGQV. phosphatidylethanolamine 35-59 annexin A5 Homo sapiens 106-115 10500152-4 1999 Exposure of phosphatidylserine and phosphatidylethanolamine on platelets, as determined by an increase in annexin V binding, was strongly stimulated by SFLLRN, thrombin, and collagen, but only to a minor extent by GYPGQV. phosphatidylethanolamine 35-59 coagulation factor II, thrombin Homo sapiens 160-168 10462379-1 1999 The liver synthesizes phosphatidylcholine (PC) de novo from choline via the CDP-choline pathway, and from phosphatidylethanolamine (PE) via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway. phosphatidylethanolamine 132-134 phosphatidylethanolamine N-methyltransferase Mus musculus 144-188 10423256-3 1999 The folding kinetic mechanism of apocytochrome c induced by zwitterionic micelles of lysophosphatidylcholine (L-PC), predominantly driven by hydrophobic lipid-protein interactions, was investigated by fluorescence stopped-flow measurements of Trp 59 and fluorescein-phosphatidylethanolamine-(FPE) labeled micelles, in combination with stopped-flow far-UV circular dichroism. phosphatidylethanolamine 266-290 proprotein convertase subtilisin/kexin type 7 Homo sapiens 85-114 10412977-4 1999 Mice lacking RmP show delayed dark adaptation, increased all-trans-retinaldehyde (all-trans-RAL) following light exposure, elevated phosphatidylethanolamine (PE) in outer segments, accumulation of the protonated Schiff base complex of all-trans-RAL and PE (N-retinylidene-PE), and striking deposition of a major lipofuscin fluorophore (A2-E) in retinal pigment epithelium (RPE). phosphatidylethanolamine 132-156 ATP-binding cassette, sub-family A (ABC1), member 4 Mus musculus 13-16 10412977-4 1999 Mice lacking RmP show delayed dark adaptation, increased all-trans-retinaldehyde (all-trans-RAL) following light exposure, elevated phosphatidylethanolamine (PE) in outer segments, accumulation of the protonated Schiff base complex of all-trans-RAL and PE (N-retinylidene-PE), and striking deposition of a major lipofuscin fluorophore (A2-E) in retinal pigment epithelium (RPE). phosphatidylethanolamine 158-160 ATP-binding cassette, sub-family A (ABC1), member 4 Mus musculus 13-16 10412977-4 1999 Mice lacking RmP show delayed dark adaptation, increased all-trans-retinaldehyde (all-trans-RAL) following light exposure, elevated phosphatidylethanolamine (PE) in outer segments, accumulation of the protonated Schiff base complex of all-trans-RAL and PE (N-retinylidene-PE), and striking deposition of a major lipofuscin fluorophore (A2-E) in retinal pigment epithelium (RPE). phosphatidylethanolamine 253-255 ATP-binding cassette, sub-family A (ABC1), member 4 Mus musculus 13-16 10412977-4 1999 Mice lacking RmP show delayed dark adaptation, increased all-trans-retinaldehyde (all-trans-RAL) following light exposure, elevated phosphatidylethanolamine (PE) in outer segments, accumulation of the protonated Schiff base complex of all-trans-RAL and PE (N-retinylidene-PE), and striking deposition of a major lipofuscin fluorophore (A2-E) in retinal pigment epithelium (RPE). phosphatidylethanolamine 253-255 ATP-binding cassette, sub-family A (ABC1), member 4 Mus musculus 13-16 10329685-12 1999 Whereas the EKI1 gene product was primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway, the CKI1 gene product was primarily responsible for phosphatidylcholine synthesis via the CDP-choline pathway. phosphatidylethanolamine 60-84 bifunctional choline kinase/ethanolamine kinase EKI1 Saccharomyces cerevisiae S288C 12-16 10086319-4 1999 With regard to the enzymes involved in the synthesis of PtdEtn, the three peroxisome proliferators enhanced the activity of phosphatidylserine (PtdSer) decarboxylase and markedly decreased the activity of CTP:phosphoethanolamine cytidylyltransferase. phosphatidylethanolamine 56-62 phosphate cytidylyltransferase 2, ethanolamine Rattus norvegicus 205-249 10191259-2 1999 Ethanolaminephosphotransferase catalyses an analogous reaction with CDP-ethanolamine as the phosphobase donor for the synthesis of phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 131-155 cut like homeobox 1 Homo sapiens 68-71 10191259-2 1999 Ethanolaminephosphotransferase catalyses an analogous reaction with CDP-ethanolamine as the phosphobase donor for the synthesis of phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 157-163 cut like homeobox 1 Homo sapiens 68-71 10101272-3 1999 In addition, we have found a PPAR-independent mechanism in which fibrates, known peroxisome proliferators, decrease hepatic secretion of very low density lipoproteins (VLDL) through inhibition of phosphatidylcholine synthesis via methylation of phosphatidylethanolamine (PE) (T. Nishimaki-Mogami et al., Biochim. phosphatidylethanolamine 245-269 peroxisome proliferator activated receptor alpha Rattus norvegicus 29-33 10353318-4 1999 The sialidase-treated LPL also showed similar hydrolyzing activity for triolein emulsified with Triton X-100, phosphatidylcholine and phosphatidylethanolamine, whereas it showed significantly increased hydrolyzing activity for triolein emulsified with phosphatidylserine and cardiolipin (152% and 183%, compared with untreated LPL, respectively). phosphatidylethanolamine 134-158 lipoprotein lipase Homo sapiens 22-25 10101272-3 1999 In addition, we have found a PPAR-independent mechanism in which fibrates, known peroxisome proliferators, decrease hepatic secretion of very low density lipoproteins (VLDL) through inhibition of phosphatidylcholine synthesis via methylation of phosphatidylethanolamine (PE) (T. Nishimaki-Mogami et al., Biochim. phosphatidylethanolamine 271-273 peroxisome proliferator activated receptor alpha Rattus norvegicus 29-33 9774389-3 1998 In contrast, thrombin accelerated the import of diacyl phosphatidylethanolamine (PE) and alkenylacyl phosphatidylethanolamine into platelets by about 4-fold. phosphatidylethanolamine 81-83 coagulation factor II, thrombin Homo sapiens 13-21 10195641-1 1999 A recombinant form of the EBV envelope glycoprotein and vaccine candidate gp340, lacking its hydrophobic transmembrane region, was incorporated into Iscoms after coupling to phosphatidyl ethanolamine via carbohydrate residues. phosphatidylethanolamine 174-199 deleted in malignant brain tumors 1 Homo sapiens 74-79 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. phosphatidylethanolamine 185-209 protein kinase C alpha Homo sapiens 38-41 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. phosphatidylethanolamine 185-209 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. phosphatidylethanolamine 185-209 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. phosphatidylethanolamine 211-217 protein kinase C alpha Homo sapiens 38-41 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. phosphatidylethanolamine 211-217 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 102-117 10049506-1 1999 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) stimulates phospholipase D (PLD)-mediated hydrolysis of both phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PKC-alpha-mediated nonphosphorylating and phosphorylating mechanisms. phosphatidylethanolamine 211-217 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 119-122 10079112-3 1999 Analysis of plasma of F2 homozygous PLTP-/- mice showed complete loss of phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, sphingomyelin, and partial loss of free cholesterol transfer activities. phosphatidylethanolamine 94-118 phospholipid transfer protein Mus musculus 36-40 9989271-1 1999 Phosphatidylethanolamine is converted to phosphatidylcholine in mammalian liver by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 0-24 phosphatidylethanolamine N-methyltransferase Homo sapiens 94-138 9989271-1 1999 Phosphatidylethanolamine is converted to phosphatidylcholine in mammalian liver by the enzyme phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 0-24 phosphatidylethanolamine N-methyltransferase Homo sapiens 140-144 10453996-4 1999 On the basis of these results it can be proposed that a functional relationship between cytochrome P450 4A1 and phosphatidylethanolamine synthesis exists in rat liver. phosphatidylethanolamine 112-136 cytochrome P450, family 4, subfamily a, polypeptide 1 Rattus norvegicus 88-107 9854020-1 1999 Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine into phosphatidylcholine. phosphatidylethanolamine 93-117 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-44 9854020-1 1999 Phosphatidylethanolamine N-methyltransferase (PEMT) is a liver-specific enzyme that converts phosphatidylethanolamine into phosphatidylcholine. phosphatidylethanolamine 93-117 phosphatidylethanolamine N-methyltransferase Homo sapiens 46-50 9845435-11 1998 Phosphatidylethanolamine incorporated in the phospholipid bilayer resulted in a lower threshold for the binding assay, whereas sphingomyelin had no influence on the binding of annexin V and cholesterol reduces binding of annexin V to lipid bilayers. phosphatidylethanolamine 0-24 annexin A5 Homo sapiens 221-230 9914152-1 1999 When human platelets are stimulated with collagen or thrombin, the asymmetric distribution of membrane lipids is disrupted as phosphatidylserine and phosphatidylethanolamine translocate from the inner monolayer to the outer monolayer. phosphatidylethanolamine 149-173 coagulation factor II, thrombin Homo sapiens 53-61 10029989-0 1999 Asymmetric distribution of phosphatidylethanolamine in C. albicans: possible mediation by CDR1, a multidrug transporter belonging to ATP binding cassette (ABC) superfamily. phosphatidylethanolamine 27-51 multidrug transporter Saccharomyces cerevisiae S288C 98-119 9894014-8 1999 Collectively, these results demonstrate that an aldehyde generated by the myeloperoxidase system of phagocytes can covalently modify the amino groups of phosphatidylethanolamine and phosphatidylserine. phosphatidylethanolamine 153-177 myeloperoxidase Homo sapiens 74-89 9774389-4 1998 Similarly, thrombin receptor-activating peptide (15 microM), collagen (10 microgram/ml), and ADP (10 microM) enhanced PE uptake. phosphatidylethanolamine 118-120 coagulation factor II, thrombin Homo sapiens 11-19 9774389-7 1998 Inhibitors of protein kinase C partially prevented thrombin-induced [14C]PE uptake, while direct activators of protein kinase C increased incorporation of [14C]PE into platelets. phosphatidylethanolamine 73-75 coagulation factor II, thrombin Homo sapiens 51-59 9774404-2 1998 We found that binding of heterotrimeric fVIIIa (A1.A2.A3-C1-C2) to synthetic vesicles with a physiologic content of 4% phosphatidylserine (PS), 76% phosphatidylcholine, and 20% phosphatidylethanolamine occurs with a 10-fold higher affinity than that of factor VIII (fVIII). phosphatidylethanolamine 177-201 coagulation factor VIII Homo sapiens 40-45 9774404-8 1998 This conclusion is based on the finding that binding of the monoclonal antibody ESH8 to the C2 domain, which is known to prevent this conformational transition, resulted in fVIIIa binding to PS/phosphatidylcholine/phosphatidylethanolamine vesicles (4/76/20) with a lower affinity similar to that of fVIII. phosphatidylethanolamine 214-238 coagulation factor VIII Homo sapiens 173-178 9765216-2 1998 Hepatocytes have a second pathway for the synthesis of phosphatidylcholine, a stepwise methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase and encoded by the Pempt gene. phosphatidylethanolamine 102-126 phosphatidylethanolamine N-methyltransferase Mus musculus 205-210 9782057-3 1998 PEBP binds to phosphatidylethanolamine and nucleotides in vitro, but its biological function in vivo is not yet known. phosphatidylethanolamine 14-38 phosphatidylethanolamine binding protein 1 Bos taurus 0-4 9788614-2 1998 After phorbol ester treatment, AA is hydrolyzed from keratinocytes primarily by the cytosolic form of phospholipase A2 (cPLA2), which exhibited a strong substrate preference for phosphatidylcholine over phosphatidylethanolamine and AA over other fatty acids. phosphatidylethanolamine 203-227 phospholipase A2, group IB, pancreas Mus musculus 102-118 9788614-2 1998 After phorbol ester treatment, AA is hydrolyzed from keratinocytes primarily by the cytosolic form of phospholipase A2 (cPLA2), which exhibited a strong substrate preference for phosphatidylcholine over phosphatidylethanolamine and AA over other fatty acids. phosphatidylethanolamine 203-227 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 120-125 9767110-8 1998 GV-PLA2 preferentially hydrolyzes phosphatidylethanolamine (PE) vesicles compared to phosphatidylcholine (PC) vesicles. phosphatidylethanolamine 34-58 phospholipase A2 group V Homo sapiens 0-7 9767110-8 1998 GV-PLA2 preferentially hydrolyzes phosphatidylethanolamine (PE) vesicles compared to phosphatidylcholine (PC) vesicles. phosphatidylethanolamine 60-62 phospholipase A2 group V Homo sapiens 0-7 9799116-5 1998 Examination of the effects of phospholipids on PLC delta3 revealed that this enzyme is inhibited by phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho). phosphatidylethanolamine 100-124 phospholipase C delta 3 Homo sapiens 47-57 9799116-5 1998 Examination of the effects of phospholipids on PLC delta3 revealed that this enzyme is inhibited by phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho). phosphatidylethanolamine 126-132 phospholipase C delta 3 Homo sapiens 47-57 9750304-6 1998 We conclude that FAB-MS can provide data on individual analogues of PE and PG from Fusobacterium spp. phosphatidylethanolamine 68-70 FA complementation group B Homo sapiens 17-20 9869164-0 1998 Inhibition of lupus anticoagulant activity by hexagonal phase phosphatidylethanolamine in the presence of prothrombin. phosphatidylethanolamine 62-86 coagulation factor II, thrombin Homo sapiens 106-117 9741591-3 1998 Whatever the medium, bulk solution or negatively charged dicetylphosphate (DCP), phosphatidylcholine/phosphatidylethanolamine/cardiolipin (PC/PE/CL) liposomes, this chemiluminescent reaction is accompanied by reduction of cytochrome c to its ferrous form. phosphatidylethanolamine 101-125 cytochrome c, somatic Homo sapiens 222-234 9729268-1 1998 Induction of neurite outgrowth by treating pheochromocytoma cells (PC12 cells) with nerve growth factor (NGF) is associated with major increases in cellular levels of diacylglycerol (DAG), an essential and probably limiting precursor in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) syntheses. phosphatidylethanolamine 266-290 nerve growth factor Rattus norvegicus 84-103 9729268-1 1998 Induction of neurite outgrowth by treating pheochromocytoma cells (PC12 cells) with nerve growth factor (NGF) is associated with major increases in cellular levels of diacylglycerol (DAG), an essential and probably limiting precursor in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) syntheses. phosphatidylethanolamine 266-290 nerve growth factor Rattus norvegicus 105-108 9729268-1 1998 Induction of neurite outgrowth by treating pheochromocytoma cells (PC12 cells) with nerve growth factor (NGF) is associated with major increases in cellular levels of diacylglycerol (DAG), an essential and probably limiting precursor in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) syntheses. phosphatidylethanolamine 292-294 nerve growth factor Rattus norvegicus 84-103 9729268-1 1998 Induction of neurite outgrowth by treating pheochromocytoma cells (PC12 cells) with nerve growth factor (NGF) is associated with major increases in cellular levels of diacylglycerol (DAG), an essential and probably limiting precursor in phosphatidylcholine (PC) and phosphatidylethanolamine (PE) syntheses. phosphatidylethanolamine 292-294 nerve growth factor Rattus norvegicus 105-108 9572868-5 1998 The fluorescence of the NBD-Pgp and MIANS-Pgp donors was quenched in a concentration-dependent manner by the rhodamine-PE and NBD-PE acceptors. phosphatidylethanolamine 119-121 ATP binding cassette subfamily B member 1 Homo sapiens 28-31 9820649-2 1998 The activation of phospholipases A2, C and D (PLA2, PLC and PLD) acting on phosphatidylcholine and phosphatidylethanolamine was determined by high performance liquid chromatography (HPLC) separation and liquid scintillation counting of water- and lipid-soluble phospholipid metabolites. phosphatidylethanolamine 99-123 LOC104974671 Bos taurus 18-44 9642289-0 1998 Genetic evidence that phosphatidylserine synthase II catalyzes the conversion of phosphatidylethanolamine to phosphatidylserine in Chinese hamster ovary cells. phosphatidylethanolamine 81-105 phosphatidylserine synthase 2 Cricetulus griseus 22-52 9649331-8 1998 This peptide (PP-5) promoted calcium-induced vesicle aggregation of phosphatidylethanolamine:phosphatidylserine LUVs. phosphatidylethanolamine 68-92 protein phosphatase 5 catalytic subunit Homo sapiens 14-18 9616153-10 1998 Interestingly, on phospholipids containing 40% phosphatidylethanolamine, the activation rate of near physiological PC concentrations ( approximately 80 nmol/L) by fXa in the presence of dextran sulfate was nearly comparable to that observed by the thrombin-TM complex. phosphatidylethanolamine 47-71 protein C, inactivator of coagulation factors Va and VIIIa Homo sapiens 115-117 9572868-5 1998 The fluorescence of the NBD-Pgp and MIANS-Pgp donors was quenched in a concentration-dependent manner by the rhodamine-PE and NBD-PE acceptors. phosphatidylethanolamine 119-121 ATP binding cassette subfamily B member 1 Homo sapiens 42-45 9556620-0 1998 Protein C inhibitor secreted from activated platelets efficiently inhibits activated protein C on phosphatidylethanolamine of platelet membrane and microvesicles. phosphatidylethanolamine 98-122 serpin family A member 5 Homo sapiens 0-19 9556620-7 1998 PCI significantly inhibited APC in the presence of phospholipid vesicles prepared using rabbit brain cephalin (RBC) or a mixture of 40% phosphatidylethanolamine (PE), 20% phosphatidylserine (PS), and 40% phosphatidylcholine (PC) with a second order rate constant of 1.0 x 10(6) M-1.min-1. phosphatidylethanolamine 136-160 serpin family A member 5 Homo sapiens 0-3 9556620-7 1998 PCI significantly inhibited APC in the presence of phospholipid vesicles prepared using rabbit brain cephalin (RBC) or a mixture of 40% phosphatidylethanolamine (PE), 20% phosphatidylserine (PS), and 40% phosphatidylcholine (PC) with a second order rate constant of 1.0 x 10(6) M-1.min-1. phosphatidylethanolamine 162-164 serpin family A member 5 Homo sapiens 0-3 9558359-0 1998 Inhibition of type I and type II phospholipase A2 by phosphatidyl-ethanolamine linked to polymeric carriers. phosphatidylethanolamine 53-78 phospholipase A2 group IB Homo sapiens 33-49 9558359-3 1998 Cell-impermeable PLA2 inhibitors (ExPLIs) were prepared by linking phosphatidylethanolamine (PE) to polymeric carriers, specifically, carboxymethylcellulose, heparin, or hyaluronic acid. phosphatidylethanolamine 67-91 phospholipase A2 group IB Homo sapiens 17-21 9558359-3 1998 Cell-impermeable PLA2 inhibitors (ExPLIs) were prepared by linking phosphatidylethanolamine (PE) to polymeric carriers, specifically, carboxymethylcellulose, heparin, or hyaluronic acid. phosphatidylethanolamine 93-95 phospholipase A2 group IB Homo sapiens 17-21 9535891-1 1998 To determine the structural basis of phosphatidylethanolamine (PE)-dependent activated protein C (APC) activity, we prepared a chimeric molecule in which the Gla domain and hydrophobic stack of protein C were replaced with the corresponding region of prothrombin. phosphatidylethanolamine 37-61 APC regulator of WNT signaling pathway Homo sapiens 98-101 9535891-1 1998 To determine the structural basis of phosphatidylethanolamine (PE)-dependent activated protein C (APC) activity, we prepared a chimeric molecule in which the Gla domain and hydrophobic stack of protein C were replaced with the corresponding region of prothrombin. phosphatidylethanolamine 63-65 APC regulator of WNT signaling pathway Homo sapiens 98-101 9516423-5 1998 PtdSer synthase-1 cDNA was stably expressed in M.9.1.1 cells which are mutant Chinese hamster ovary cells defective in PtdSer synthase-1 activity, are ethanolamine auxotrophs, and have a reduced content of PtdSer and phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 217-241 phosphatidylserine synthase 1 Mus musculus 0-17 9616153-10 1998 Interestingly, on phospholipids containing 40% phosphatidylethanolamine, the activation rate of near physiological PC concentrations ( approximately 80 nmol/L) by fXa in the presence of dextran sulfate was nearly comparable to that observed by the thrombin-TM complex. phosphatidylethanolamine 47-71 coagulation factor X Homo sapiens 163-166 9487144-3 1998 We examined involvement of PLD and PKC in the hydrolysis and resynthesis of PtdCho and phosphatidylethanolamine stimulated by beta-TPA, bryostatin (a non-phorbol PKC activator) and oleic acid (18:1n-9) in the four cell lines. phosphatidylethanolamine 87-111 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 27-30 9574810-1 1998 Ethanolamine, a positively charged hydrophilic component of the phosphatidylethanolamine (PE) which is also a precursor of phosphatidylcholine (PC), enhances the repair processes 24 h after carbon tetrachloride (CCl4) intoxication of mouse liver. phosphatidylethanolamine 64-88 chemokine (C-C motif) ligand 4 Mus musculus 212-216 9574810-1 1998 Ethanolamine, a positively charged hydrophilic component of the phosphatidylethanolamine (PE) which is also a precursor of phosphatidylcholine (PC), enhances the repair processes 24 h after carbon tetrachloride (CCl4) intoxication of mouse liver. phosphatidylethanolamine 90-92 chemokine (C-C motif) ligand 4 Mus musculus 212-216 9448723-2 1998 Treatment of cells with Naja mocambique mocambique phospholipase A2 reduced the pool sizes of phosphatidylcholine and phosphatidylethanolamine compared with controls. phosphatidylethanolamine 118-142 phospholipase A2 group IB Rattus norvegicus 51-67 9701504-3 1998 Since PE represents a class of phospholipids (PL) prerequisite for proper functioning of CYP4A1, and the PEBE reaction is an inducible pathway of PL synthesis in hepatocytes under metabolic stress, one may speculate that this reaction is switched on when extensive remodelling of PL molecular species or/and massive synthesis of lipid bilayer components for membrane assembly is required. phosphatidylethanolamine 6-8 cytochrome P450, family 4, subfamily a, polypeptide 1 Rattus norvegicus 89-95 9538003-5 1998 Phospholipid subclass distribution of apoA-ISeattle nascent HDL demonstrated a significant increase in sphingomyelin and phosphatidylethanolamine compared to wild type. phosphatidylethanolamine 121-145 apolipoprotein A1 Homo sapiens 38-51 9516423-1 1998 Overexpression in rat hepatoma cells inhibits the CDP-ethanolamine pathway for phosphatidylethanolamine biosynthesis. phosphatidylethanolamine 79-103 cut-like homeobox 1 Rattus norvegicus 50-53 9578154-4 1998 Furthermore, pretreatment with PKA activators prevented much of the AIF4(-)-induced loss of [3H]AA from phosphatidylcholine and phosphatidylethanolamine in prelabeled osteoblasts. phosphatidylethanolamine 128-152 itchy E3 ubiquitin protein ligase Homo sapiens 68-72 9425108-8 1998 The ratio of [14C]palmitic acid incorporation into phosphatidylcholine and phosphatidylethanolamine of A-FABP-cDNA-transfected clones changed in the opposite direction in differentiation medium from that of mock- and H-FABP-cDNA-transfected clones. phosphatidylethanolamine 75-99 fatty acid binding protein 4 Rattus norvegicus 103-109 9516423-5 1998 PtdSer synthase-1 cDNA was stably expressed in M.9.1.1 cells which are mutant Chinese hamster ovary cells defective in PtdSer synthase-1 activity, are ethanolamine auxotrophs, and have a reduced content of PtdSer and phosphatidylethanolamine (PtdEtn). phosphatidylethanolamine 243-249 phosphatidylserine synthase 1 Mus musculus 0-17 9516423-11 1998 Moreover, the CDP-ethanolamine pathway for PtdEtn biosynthesis was inhibited. phosphatidylethanolamine 43-49 cut-like homeobox 1 Mus musculus 14-17 9469583-10 1998 Labeling with [14C]choline and [14C]ethanolamine confirmed the increase in the rate of phosphatidylcholine synthesis and the decreased rate of phosphatidylethanolamine synthesis through their respective CDP pathways. phosphatidylethanolamine 143-167 cut like homeobox 1 Homo sapiens 203-206 9405398-5 1997 p37 also metabolized phosphatidylethanolamine efficiently, but it had less activity toward phosphatidylinositol and little or no activity toward phosphatidylserine. phosphatidylethanolamine 21-45 nucleoporin 37 Homo sapiens 0-3 9481780-6 1998 Secreted PLA2 isozymes that display a substrate preference for the negatively charged aminophospholipids (e.g. phosphatidylserine or phosphatidylethanolamine) in the exoplasmic membrane may affect cell function and reactivity via a process of "membrane polishing", that is, the preferentially removal of aminophospholipids from the exoplasmic leaflet of the cell membranes. phosphatidylethanolamine 133-157 phospholipase A2 group IIA Homo sapiens 9-13 9371769-2 1997 Liver has an alternative pathway in which phosphatidylcholine is made by methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 88-112 phosphatidylethanolamine N-methyltransferase Mus musculus 126-170 9558730-16 1998 We have found that the total C18:2 and 20:4 diacyl species of phosphatidylethanolamine in peritoneal macrophages relates in a positive curvilinear fashion with dietary linoleic acid intake; that TNF induced IL1 and IL6 production relate in a positive curvilinear fashion to linoleic acid intake; that leukotriene B4 production relates positively with dietary linoleic acid intake over a range of moderate intakes and is suppressed at high intakes, while PGE2 production is enhanced. phosphatidylethanolamine 62-86 tumor necrosis factor Rattus norvegicus 195-198 9558730-16 1998 We have found that the total C18:2 and 20:4 diacyl species of phosphatidylethanolamine in peritoneal macrophages relates in a positive curvilinear fashion with dietary linoleic acid intake; that TNF induced IL1 and IL6 production relate in a positive curvilinear fashion to linoleic acid intake; that leukotriene B4 production relates positively with dietary linoleic acid intake over a range of moderate intakes and is suppressed at high intakes, while PGE2 production is enhanced. phosphatidylethanolamine 62-86 interleukin 6 Rattus norvegicus 215-218 9426232-6 1997 The present study shows that phospholipase A (A2/A1) activity which cleaves the acyl group from both sn-2 and sn-1 positions of phosphatidylethanolamine (PtdEtn) is increased in HL-60 cells during differentiation to granulocyte-like cells. phosphatidylethanolamine 128-152 phospholipase A and acyltransferase 1 Homo sapiens 29-44 9426232-6 1997 The present study shows that phospholipase A (A2/A1) activity which cleaves the acyl group from both sn-2 and sn-1 positions of phosphatidylethanolamine (PtdEtn) is increased in HL-60 cells during differentiation to granulocyte-like cells. phosphatidylethanolamine 154-160 phospholipase A and acyltransferase 1 Homo sapiens 29-44 9371692-1 1997 In this work, we determined the effects of sphingosine 1-phosphate (S1P) on phospholipase D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn), and evaluated the effects of the water-soluble product ethanolamine on S1P-induced DNA synthesis in NIH 3T3 cells. phosphatidylethanolamine 121-145 sphingosine-1-phosphate receptor 1 Mus musculus 68-71 9371692-1 1997 In this work, we determined the effects of sphingosine 1-phosphate (S1P) on phospholipase D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn), and evaluated the effects of the water-soluble product ethanolamine on S1P-induced DNA synthesis in NIH 3T3 cells. phosphatidylethanolamine 121-145 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 9371692-1 1997 In this work, we determined the effects of sphingosine 1-phosphate (S1P) on phospholipase D (PLD)-mediated hydrolysis of phosphatidylethanolamine (PtdEtn), and evaluated the effects of the water-soluble product ethanolamine on S1P-induced DNA synthesis in NIH 3T3 cells. phosphatidylethanolamine 147-153 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 9371769-2 1997 Liver has an alternative pathway in which phosphatidylcholine is made by methylation of phosphatidylethanolamine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 88-112 phosphatidylethanolamine N-methyltransferase Mus musculus 172-176 9344462-1 1997 Stimulation of phosphatidylethanolamine (PtdEtn) synthesis by the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) has reportedly been found only in hepatocytes expressing the alpha-, betaII-, epsilon-, and zeta-PKC isozymes. phosphatidylethanolamine 15-39 protein kinase C alpha Homo sapiens 84-87 9421192-2 1997 Ethanolamine kinase catalyzes the initial step in the CDP-ethanolamine pathway for phosphatidylethanolamine synthesis. phosphatidylethanolamine 83-107 cut like homeobox 1 Homo sapiens 54-57 9421195-4 1997 Arachidonic acid release by sPLA2 was dependent on the extracellular Ca2+ and was accompanied by preferential hydrolysis of phosphatidylethanolamine and phosphatidylserine in the membrane phospholipids. phosphatidylethanolamine 124-148 phospholipase A2 group IIA Homo sapiens 28-33 9344462-1 1997 Stimulation of phosphatidylethanolamine (PtdEtn) synthesis by the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) has reportedly been found only in hepatocytes expressing the alpha-, betaII-, epsilon-, and zeta-PKC isozymes. phosphatidylethanolamine 41-47 protein kinase C alpha Homo sapiens 84-87 9344462-7 1997 In contrast, in MCF-7 cells overexpressing PKC-alpha, and as a consequence also expressing the betaI- and betaII-PKC isoforms, PMA effectively stimulated the synthesis of PtdEtn. phosphatidylethanolamine 171-177 protein kinase C alpha Homo sapiens 43-52 9359412-2 1997 Neither enzyme binds appreciably to pure phosphatidylcholine vesicles at lipid concentrations up to 10(-3) M. PLC-beta1 and PLC-beta2 bind vesicles composed of phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine (molar ratio 1:1:1) with an approximate Kd of 10(-5) M. Inclusion of 2% PtdIns(4,5)P2 in these vesicles had no effect on the affinity of this interaction. phosphatidylethanolamine 204-228 phospholipase C beta 1 Homo sapiens 110-119 9366248-2 1997 When stimulated by polyamines, mitochondrial PLD utilized endogenous phosphatidylethanolamine (PE) as substrate whereas stimulated by monoamines, both PE and phosphatidylcholine (PC) were hydrolysed. phosphatidylethanolamine 69-93 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-48 9366248-2 1997 When stimulated by polyamines, mitochondrial PLD utilized endogenous phosphatidylethanolamine (PE) as substrate whereas stimulated by monoamines, both PE and phosphatidylcholine (PC) were hydrolysed. phosphatidylethanolamine 95-97 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 45-48 9353153-7 1997 The dominant antibody in the kidney eluate of mercury-injected mice was of IgG1 isotype and found to be directed against double-stranded DNA, collagen, cardiolipin, phosphatidylethanolamine, and the hapten trinitrophenol, but not against nucleolar antigens. phosphatidylethanolamine 165-189 LOC105243590 Mus musculus 75-79 9299527-1 1997 Synthetic melittin inhibited the enzymatic activity of secretory phospholipase A2 (PLA2) from various sources, including bee and snake venoms, bovine pancreas, and synovial fluid from rheumatoid arthritis patients, irrespective of substrate (e.g., [14C]-phosphatidylcholine or phosphatidylethanolamine vesicles and [3H]-oleic acid-labeled E.coli). phosphatidylethanolamine 277-301 phospholipase A2 group IIA Homo sapiens 83-87 9268710-3 1997 It was found that kinase FA/GSK-3alpha can associate with NaOH-extracted brain membranes and selectively interact with several kinds of reconstituted phospholipid vesicles including phosphatidic acid (PA), phosphatidyl ethanolamine (PE), phosphatidyl inositol (PI), and phosphatidyl serine (PS) vesicles. phosphatidylethanolamine 206-231 glycogen synthase kinase 3 alpha Homo sapiens 28-38 9268710-3 1997 It was found that kinase FA/GSK-3alpha can associate with NaOH-extracted brain membranes and selectively interact with several kinds of reconstituted phospholipid vesicles including phosphatidic acid (PA), phosphatidyl ethanolamine (PE), phosphatidyl inositol (PI), and phosphatidyl serine (PS) vesicles. phosphatidylethanolamine 233-235 glycogen synthase kinase 3 alpha Homo sapiens 28-38 9463889-8 1998 Incorporation of phosphatidylethanolamine or phosphatidylserine into phosphatidylcholine vesicles reduced the binding of PDC-109, suggesting that both the density of phosphorylcholine groups and the surface charge determine the interaction of the seminal plasma protein with the surface of the membrane. phosphatidylethanolamine 17-41 seminal plasma protein PDC-109 Bos taurus 121-128 9370326-1 1997 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 61-85 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 0-44 9370326-1 1997 Phosphatidylethanolamine N-methyltransferase (PEMT) converts phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 61-85 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 46-50 9370326-7 1997 Deletion of the PEMT gene eliminates all activity in liver that converts phosphatidylethanolamine to phosphatidylcholine. phosphatidylethanolamine 73-97 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 16-20 9370326-8 1997 The activity of PEMT is regulated by supply of the substrates, phosphatidylethanolamine and S-adenosylmethionine, and by the product S-adenosylhomocysteine. phosphatidylethanolamine 63-87 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 16-20 9294443-1 1997 In the yeast Saccharomyces cerevisiae, the products of two genes (PSD1 and PSD2) are able to catalyze the decarboxylation of phosphatidylserine (PS) to produce phosphatidylethanolamine (PE) (C. J. Clancey, S. Chang, and W. Dowhan, J. Biol. phosphatidylethanolamine 160-184 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 66-70 9294443-1 1997 In the yeast Saccharomyces cerevisiae, the products of two genes (PSD1 and PSD2) are able to catalyze the decarboxylation of phosphatidylserine (PS) to produce phosphatidylethanolamine (PE) (C. J. Clancey, S. Chang, and W. Dowhan, J. Biol. phosphatidylethanolamine 160-184 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 75-79 9294443-1 1997 In the yeast Saccharomyces cerevisiae, the products of two genes (PSD1 and PSD2) are able to catalyze the decarboxylation of phosphatidylserine (PS) to produce phosphatidylethanolamine (PE) (C. J. Clancey, S. Chang, and W. Dowhan, J. Biol. phosphatidylethanolamine 186-188 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 66-70 9294443-1 1997 In the yeast Saccharomyces cerevisiae, the products of two genes (PSD1 and PSD2) are able to catalyze the decarboxylation of phosphatidylserine (PS) to produce phosphatidylethanolamine (PE) (C. J. Clancey, S. Chang, and W. Dowhan, J. Biol. phosphatidylethanolamine 186-188 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 75-79 9323586-5 1997 In vitro assays of enzymes involved in SM metabolism found no change in PC:ceramide cholinephosphotransferase, but the NADe-fed animals had higher phosphatidylethanolamine:ceramide ethanolaminephosphotransferase activity, greater incorporation of methyl groups from [methyl-3H]-S-adenosyl methionine into SM, and a lower neutral sphingomyelinase activity. phosphatidylethanolamine 147-171 brain expressed X-linked 3 Rattus norvegicus 119-123 9280295-3 1997 In this study, we have shown that intestinal mitochondria contain an active phospholipase D (PLD) which is activated by oxidants, Ca2+ or polyamines and this results in degradation of phosphatidylethanolamine (PE) and formation of phosphatidic acid (PA). phosphatidylethanolamine 184-208 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-91 9280295-3 1997 In this study, we have shown that intestinal mitochondria contain an active phospholipase D (PLD) which is activated by oxidants, Ca2+ or polyamines and this results in degradation of phosphatidylethanolamine (PE) and formation of phosphatidic acid (PA). phosphatidylethanolamine 184-208 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 9280295-3 1997 In this study, we have shown that intestinal mitochondria contain an active phospholipase D (PLD) which is activated by oxidants, Ca2+ or polyamines and this results in degradation of phosphatidylethanolamine (PE) and formation of phosphatidic acid (PA). phosphatidylethanolamine 210-212 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 76-91 9280295-3 1997 In this study, we have shown that intestinal mitochondria contain an active phospholipase D (PLD) which is activated by oxidants, Ca2+ or polyamines and this results in degradation of phosphatidylethanolamine (PE) and formation of phosphatidic acid (PA). phosphatidylethanolamine 210-212 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 93-96 9359412-2 1997 Neither enzyme binds appreciably to pure phosphatidylcholine vesicles at lipid concentrations up to 10(-3) M. PLC-beta1 and PLC-beta2 bind vesicles composed of phosphatidylcholine, phosphatidylserine and phosphatidylethanolamine (molar ratio 1:1:1) with an approximate Kd of 10(-5) M. Inclusion of 2% PtdIns(4,5)P2 in these vesicles had no effect on the affinity of this interaction. phosphatidylethanolamine 204-228 phospholipase C beta 2 Homo sapiens 124-133 9168822-6 1997 The specific binding of FL-SA-Ro to the apoptotic cells was also confirmed using a flourescence-activated cell sorter and the time-dependent cell surface exposure of PE correlated well with the exposure of PS, as detected by the binding of annexin V. phosphatidylethanolamine 166-168 annexin A5 Mus musculus 240-249 9360016-4 1997 The activity of delta 5-desaturase was higher in the upper than in the lower portions of the villus, and was greater in P than in S. The activity of delta 9- and delta 6-desaturases did not vary along the villus or with changes in dietary S or P. The two predominant EMM phospholipids were phosphatidylcholine and phosphatidylethanolamine, and these did not vary along the villus or with changes in diet. phosphatidylethanolamine 314-338 fatty acid desaturase 1 Rattus norvegicus 16-34 9260748-7 1997 The phospholipid asymmetry of NF1T plasma membrane followed the general features of phospholipid asymmetry in eukaryotic cells: sphingomyelin and phosphatidylcholine were preferentially located in the outer leaflet (90% and 89%, respectively) while the aminophospholipids phosphatidylethanolamine, phosphatidylserine, and phosphatidylinositol were in the inner half of the membrane (85%, 96%, and 69%, respectively). phosphatidylethanolamine 272-296 neurofibromin 1 Homo sapiens 30-33 9185174-7 1997 Bat PKC, however, made use of other phospholipids and showed relative activities of 100:81:33:42 for euthermic PKC and 100:91:45:35 for hibernator PKC with phosphatidylserine, phosphatidylinositol, phosphatidylcholine, and phosphatidylethanolamine (each at 50 microM), respectively. phosphatidylethanolamine 223-247 protein kinase C, gamma Rattus norvegicus 4-7 9250704-2 1997 Asymmetry is maintained by a membrane associated ATP-dependent aminophospholipid translocase that preferentially relocates PS and PE from the outer to the inner monolayer. phosphatidylethanolamine 130-132 ATPase phospholipid transporting 8A1 Homo sapiens 63-92 9188469-9 1997 hGX sPLA2 prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine. phosphatidylethanolamine 18-42 phospholipase A2 group X Homo sapiens 4-9 9083101-1 1997 CTP-phosphoethanolamine cytidylyltransferase (ET) is the enzyme that catalyzes the formation of CDP-ethanolamine in the phosphatidylethanolamine biosynthetic pathway from ethanolamine. phosphatidylethanolamine 120-144 phosphate cytidylyltransferase 2, ethanolamine Homo sapiens 0-44 9032461-5 1997 Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE). phosphatidylethanolamine 227-251 phospholipase A2 group IB Homo sapiens 32-39 9032461-5 1997 Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE). phosphatidylethanolamine 227-251 phospholipase A2 group IB Homo sapiens 58-65 9032461-5 1997 Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE). phosphatidylethanolamine 253-255 phospholipase A2 group IB Homo sapiens 32-39 9032461-5 1997 Kinetic analysis of recombinant hs-PLA2 demonstrates that hs-PLA2 strongly prefers PA as substrate over other phospholipids found in the mammalian plasma membrane including phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE). phosphatidylethanolamine 253-255 phospholipase A2 group IB Homo sapiens 58-65 9032461-9 1997 Thus it appears that Lys-69 is at least partially involved in the PA specificity of hs-PLA2 and Glu-56 in the distinction between PE and PC. phosphatidylethanolamine 130-132 phospholipase A2 group IB Homo sapiens 84-91 9230069-0 1997 Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3. phosphatidylethanolamine 53-77 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 121-125 9230069-0 1997 Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3. phosphatidylethanolamine 53-77 drug-responsive transcription factor PDR3 Saccharomyces cerevisiae S288C 130-134 9230069-2 1997 We report here that PDR1 and PDR3 also regulate the transcription of one or more undetermined genes that translocate endogenous and fluorescent-labeled (M-C6-NBD-PE) phosphatidylethanolamine across the plasma membrane. phosphatidylethanolamine 166-190 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 20-24 9230069-2 1997 We report here that PDR1 and PDR3 also regulate the transcription of one or more undetermined genes that translocate endogenous and fluorescent-labeled (M-C6-NBD-PE) phosphatidylethanolamine across the plasma membrane. phosphatidylethanolamine 166-190 drug-responsive transcription factor PDR3 Saccharomyces cerevisiae S288C 29-33 9230069-12 1997 These data demonstrated that PDR1 and PDR3 regulate the net rate of M-C6-NBD-PE translocation (flip-flop) and the steady-state distribution of endogenous phosphatidylethanolamine across the plasma membrane. phosphatidylethanolamine 154-178 drug-responsive transcription factor PDR1 Saccharomyces cerevisiae S288C 29-33 9230069-12 1997 These data demonstrated that PDR1 and PDR3 regulate the net rate of M-C6-NBD-PE translocation (flip-flop) and the steady-state distribution of endogenous phosphatidylethanolamine across the plasma membrane. phosphatidylethanolamine 154-178 drug-responsive transcription factor PDR3 Saccharomyces cerevisiae S288C 38-42 9219902-6 1997 Whereas venom PLA2 was cytolytic in the presence of either phosphatidylcholine or phosphatidylethanolamine (PE), rh-sPLA2 caused cell death only in the presence of PE. phosphatidylethanolamine 82-106 phospholipase A2 group IIA Homo sapiens 14-18 9219902-6 1997 Whereas venom PLA2 was cytolytic in the presence of either phosphatidylcholine or phosphatidylethanolamine (PE), rh-sPLA2 caused cell death only in the presence of PE. phosphatidylethanolamine 108-110 phospholipase A2 group IIA Homo sapiens 14-18 9223654-10 1997 In conclusion; in EFAD Hep G2 cells delta-6- and delta-5-desaturase both were found to be upregulated and eicosanoid precursors were distributed more into phosphatidyl ethanolamine. phosphatidylethanolamine 155-180 EPH receptor B6 Homo sapiens 23-26 9153408-0 1997 Phosphatidylcholine and phosphatidylethanolamine behave as substrates of the human MDR1 P-glycoprotein. phosphatidylethanolamine 24-48 ATP binding cassette subfamily B member 1 Homo sapiens 83-87 9149106-1 1997 Lysophosphatidylcholine (LysoPtdCho) and lysophosphatidylethanolamine (LysoPtdEtn), which are formed by phospholipase A2-catalyzed hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), respectively, are proposed to be involved in protein kinase C (PKC) activation. phosphatidylethanolamine 45-69 protein kinase C iota Homo sapiens 276-279 9149106-1 1997 Lysophosphatidylcholine (LysoPtdCho) and lysophosphatidylethanolamine (LysoPtdEtn), which are formed by phospholipase A2-catalyzed hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), respectively, are proposed to be involved in protein kinase C (PKC) activation. phosphatidylethanolamine 75-81 protein kinase C iota Homo sapiens 276-279 9150250-7 1997 In preparations from diabetic animals phosphatidylethanolamine formed in this manner was increased in the presence of an inhibitor of cytosolic phospholipase A2, indicating that it may provide a substrate for phospholipase A2 activity; an effect not seen in cultured cells maintained at raised glucose concentrations. phosphatidylethanolamine 38-62 phospholipase A2 group IVA Rattus norvegicus 134-160 9150250-7 1997 In preparations from diabetic animals phosphatidylethanolamine formed in this manner was increased in the presence of an inhibitor of cytosolic phospholipase A2, indicating that it may provide a substrate for phospholipase A2 activity; an effect not seen in cultured cells maintained at raised glucose concentrations. phosphatidylethanolamine 38-62 phospholipase A2 group IB Rattus norvegicus 144-160 9163343-2 1997 As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line. phosphatidylethanolamine 204-228 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-141 9163343-2 1997 As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line. phosphatidylethanolamine 204-228 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 143-146 9163343-2 1997 As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line. phosphatidylethanolamine 230-236 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 126-141 9163343-2 1997 As part of an effort to identify the defect(s) in JB6 P- cells that might prevent the promoting effect of PMA, stimulation of phospholipase D (PLD)-mediated hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn) by PMA as well as the rate of phospholipid synthesis were compared in three P+ variants, two P- variants and a transformed variant of the JB6 cell line. phosphatidylethanolamine 230-236 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 143-146 9048565-10 1997 Apolipoprotein A-IV strongly stimulated the hydrolysis of phosphatidylcholine and phosphatidylethanolamine in both lipoproteins, while the hydrolysis of triglycerides was completely inhibited. phosphatidylethanolamine 82-106 apolipoprotein A4 Homo sapiens 0-19 8999915-13 1997 Competition binding assays indicate that the binding of SAP to laminin is inhibited by both SAP and its analog, C-reactive protein, as well as phosphatidylethanolamine. phosphatidylethanolamine 143-167 amyloid P component, serum Homo sapiens 56-59 8995222-0 1997 Identification of a novel Ca2+-dependent, phosphatidylethanolamine-hydrolyzing phospholipase D in yeast bearing a disruption in PLD1. phosphatidylethanolamine 42-66 phospholipase D Saccharomyces cerevisiae S288C 79-94 9006000-5 1997 Phosphatidylinositol (PI), phosphatidylcholine, and a fluorescently labeled derivative of phosphatidylethanolamine (R-PE) are each transferred by LBP from membranes to HDL particles. phosphatidylethanolamine 90-114 lipopolysaccharide binding protein Homo sapiens 146-149 8995222-0 1997 Identification of a novel Ca2+-dependent, phosphatidylethanolamine-hydrolyzing phospholipase D in yeast bearing a disruption in PLD1. phosphatidylethanolamine 42-66 phospholipase D Saccharomyces cerevisiae S288C 128-132 9138443-5 1997 RESULTS: Illustrations of how certain plasma proteins beta 2 glycoprotein I, prothrombin, high and low molecular weight kininogens interact with the anionic phospholipids cardiolipin and phosphatidylserine and the zwitterionic phospholipid, phosphatidylethanolamine are shown and discussed. phosphatidylethanolamine 241-265 coagulation factor II, thrombin Homo sapiens 77-88 9199889-3 1997 Free radical exposure did not alter neutral lipids, but among the phospholipids, phosphatidylethanolamine (PE) content was decreased on exposure to superoxide anion, generated by xanthine-xanthine oxidase or menadione with a concomitant increase in the level of phosphatidic acid (PA), suggesting activation of phospholipase D (PLD). phosphatidylethanolamine 81-105 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 311-326 8977419-5 1997 Treatment with IL-1 beta also promoted a significant decrease in the cellular content of [3H]phospholipids (apparently phosphatidylethanolamine but not phosphatidylcholine). phosphatidylethanolamine 119-143 interleukin 1 beta Rattus norvegicus 15-24 9199889-3 1997 Free radical exposure did not alter neutral lipids, but among the phospholipids, phosphatidylethanolamine (PE) content was decreased on exposure to superoxide anion, generated by xanthine-xanthine oxidase or menadione with a concomitant increase in the level of phosphatidic acid (PA), suggesting activation of phospholipase D (PLD). phosphatidylethanolamine 81-105 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 328-331 9199889-3 1997 Free radical exposure did not alter neutral lipids, but among the phospholipids, phosphatidylethanolamine (PE) content was decreased on exposure to superoxide anion, generated by xanthine-xanthine oxidase or menadione with a concomitant increase in the level of phosphatidic acid (PA), suggesting activation of phospholipase D (PLD). phosphatidylethanolamine 107-109 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 311-326 9199889-3 1997 Free radical exposure did not alter neutral lipids, but among the phospholipids, phosphatidylethanolamine (PE) content was decreased on exposure to superoxide anion, generated by xanthine-xanthine oxidase or menadione with a concomitant increase in the level of phosphatidic acid (PA), suggesting activation of phospholipase D (PLD). phosphatidylethanolamine 107-109 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 328-331 9007991-5 1997 As monitored by anti-factor IX:Ca (II)-specific antibodies and by the quenching of intrinsic fluorescence, all these factor IX species underwent the Ca(II)-induced conformational transition required for phospholipid membrane binding and bound equivalently to phospholipid vesicles composed of phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. phosphatidylethanolamine 338-362 carbonic anhydrase 2 Homo sapiens 149-155 9453451-4 1997 To elucidate the mechanisms involved, we examined the activity of phospholipase A2 (PLA2) reactive against phosphatidylcholine or phosphatidylethanolamine (PE), the activity of phospholipase C (PLC), and the levels of cyclooxygenase (COX) in cortical and medullary tubules from SOC and BUO rats. phosphatidylethanolamine 130-154 phospholipase A2 group IB Rattus norvegicus 66-82 9453451-4 1997 To elucidate the mechanisms involved, we examined the activity of phospholipase A2 (PLA2) reactive against phosphatidylcholine or phosphatidylethanolamine (PE), the activity of phospholipase C (PLC), and the levels of cyclooxygenase (COX) in cortical and medullary tubules from SOC and BUO rats. phosphatidylethanolamine 130-154 phospholipase A2 group IB Rattus norvegicus 84-88 9453451-4 1997 To elucidate the mechanisms involved, we examined the activity of phospholipase A2 (PLA2) reactive against phosphatidylcholine or phosphatidylethanolamine (PE), the activity of phospholipase C (PLC), and the levels of cyclooxygenase (COX) in cortical and medullary tubules from SOC and BUO rats. phosphatidylethanolamine 156-158 phospholipase A2 group IB Rattus norvegicus 66-82 9453451-4 1997 To elucidate the mechanisms involved, we examined the activity of phospholipase A2 (PLA2) reactive against phosphatidylcholine or phosphatidylethanolamine (PE), the activity of phospholipase C (PLC), and the levels of cyclooxygenase (COX) in cortical and medullary tubules from SOC and BUO rats. phosphatidylethanolamine 156-158 phospholipase A2 group IB Rattus norvegicus 84-88 8931495-1 1996 Nerve growth cones isolated from fetal rat brain exhibit in their cytosol a robust level of phospholipase A2 activity hydrolyzing phosphatidylinositol (PI) and phosphatidylethanolamine (PE) but not phosphatidylcholine (PC). phosphatidylethanolamine 160-184 phospholipase A2 group IB Rattus norvegicus 92-108 8938187-2 1996 After incorporation into the outer membrane leaflet spin-labeled aminophospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) moved rapidly to the inner monolayer, whereas the analog of phosphatidylcholine (PC) disappeared more slowly from the outer leaflet. phosphatidylethanolamine 112-136 spindlin 1 Homo sapiens 52-56 8938187-2 1996 After incorporation into the outer membrane leaflet spin-labeled aminophospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE) moved rapidly to the inner monolayer, whereas the analog of phosphatidylcholine (PC) disappeared more slowly from the outer leaflet. phosphatidylethanolamine 138-140 spindlin 1 Homo sapiens 52-56 8931495-1 1996 Nerve growth cones isolated from fetal rat brain exhibit in their cytosol a robust level of phospholipase A2 activity hydrolyzing phosphatidylinositol (PI) and phosphatidylethanolamine (PE) but not phosphatidylcholine (PC). phosphatidylethanolamine 186-188 phospholipase A2 group IB Rattus norvegicus 92-108 8931495-9 1996 Our data indicate growth cones contain two high-molecular-weight forms of phospholipase A2 that share many properties with known, Ca(2+)-independent cytosolic phospholipase A2 species but that appear to be monoselective for PI and PE, respectively. phosphatidylethanolamine 231-233 phospholipase A2 group IB Rattus norvegicus 74-90 8910539-0 1996 Protein kinase Calpha is a major mediator of the stimulatory effect of phorbol ester on phospholipase D-mediated hydrolysis of phosphatidylethanolamine. phosphatidylethanolamine 127-151 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 88-103 8910539-2 1996 To determine the role of various PKC isozymes in the regulation of PLD-mediated phosphatidylethanolamine (PtdEtn) hydrolysis, MCF-7 human breast carcinoma cells overexpressing the alpha- and theta-isoforms, and R6 rat fibroblasts overexpressing the alpha-, betaI-, and epsilon-isoforms were used. phosphatidylethanolamine 80-104 protein kinase C alpha Homo sapiens 33-36 8910539-2 1996 To determine the role of various PKC isozymes in the regulation of PLD-mediated phosphatidylethanolamine (PtdEtn) hydrolysis, MCF-7 human breast carcinoma cells overexpressing the alpha- and theta-isoforms, and R6 rat fibroblasts overexpressing the alpha-, betaI-, and epsilon-isoforms were used. phosphatidylethanolamine 80-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-70 8910539-2 1996 To determine the role of various PKC isozymes in the regulation of PLD-mediated phosphatidylethanolamine (PtdEtn) hydrolysis, MCF-7 human breast carcinoma cells overexpressing the alpha- and theta-isoforms, and R6 rat fibroblasts overexpressing the alpha-, betaI-, and epsilon-isoforms were used. phosphatidylethanolamine 106-112 protein kinase C alpha Homo sapiens 33-36 8910539-2 1996 To determine the role of various PKC isozymes in the regulation of PLD-mediated phosphatidylethanolamine (PtdEtn) hydrolysis, MCF-7 human breast carcinoma cells overexpressing the alpha- and theta-isoforms, and R6 rat fibroblasts overexpressing the alpha-, betaI-, and epsilon-isoforms were used. phosphatidylethanolamine 106-112 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-70 8910539-4 1996 Stable expression of PKC-alpha in MCF-7 cells, which was accompanied by increased levels of the betaI- and theta-isoforms as well, greatly enhanced both PMA-induced PLD-mediated formation of phosphatidylethanol (approximately 5-fold) and the hydrolysis of PtdEtn (2.5-2.9-fold) and PtdCho (5.5-7.2-fold). phosphatidylethanolamine 256-262 protein kinase C alpha Homo sapiens 21-30 8897699-0 1996 Autoantibodies to kininogen-phosphatidylethanolamine complexes augment thrombin-induced platelet aggregation. phosphatidylethanolamine 28-52 coagulation factor II, thrombin Homo sapiens 71-79 8982874-3 1996 In an Ect- mutant that also carried the cho1 mutation, phosphatidylethanolamine accounted for less than 2% of total phospholipids, suggesting the importance of ECT in phosphatidylethanolamine synthesis. phosphatidylethanolamine 55-79 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 40-44 8982874-3 1996 In an Ect- mutant that also carried the cho1 mutation, phosphatidylethanolamine accounted for less than 2% of total phospholipids, suggesting the importance of ECT in phosphatidylethanolamine synthesis. phosphatidylethanolamine 167-191 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 40-44 8978486-1 1996 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in the mammalian liver via three sequential methylations. phosphatidylethanolamine 80-104 phosphatidylethanolamine N-methyltransferase Homo sapiens 0-44 8978486-1 1996 Phosphatidylethanolamine N-methyltransferase (PEMT) catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in the mammalian liver via three sequential methylations. phosphatidylethanolamine 80-104 phosphatidylethanolamine N-methyltransferase Homo sapiens 46-50 8908155-7 1996 PLTP mediated equally the transfer of the various headgroup derivatives except phosphatidylethanolamine (PE), which was transferred 2-3-fold more slowly. phosphatidylethanolamine 105-107 phospholipid transfer protein Homo sapiens 0-4 8898920-2 1996 After PCD was induced in K562 cells, analysis of phospholipid composition, fatty acids and cholesterol content in their membranes showed a decrease in phosphatidylethanolamine and an increase in phosphatidylserine, cardiolipin and phosphatidic acid. phosphatidylethanolamine 151-175 dynein axonemal heavy chain 5 Homo sapiens 6-9 9084669-7 1996 Inclusion of phosphatidylethanolamine (PE) or sphingomyelin (SM) with PS, or Mg2+ or Zn2+ with Ca2+, strongly inhibited activity; incorporation of annexin V increased SNAC activity. phosphatidylethanolamine 39-41 annexin A5 Homo sapiens 147-156 8814297-0 1996 Identification of a novel, Ca(2+)-dependent phospholipase D with preference for phosphatidylserine and phosphatidylethanolamine in Saccharomyces cerevisiae. phosphatidylethanolamine 103-127 phospholipase D Saccharomyces cerevisiae S288C 44-59 8906581-5 1996 12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells. phosphatidylethanolamine 195-219 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-82 8906581-5 1996 12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells. phosphatidylethanolamine 195-219 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-87 8906581-5 1996 12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells. phosphatidylethanolamine 221-227 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 67-82 8906581-5 1996 12-0-Tetradecanoylphorbol 13-acetate (TPA) stimulation activated a phospholipase D (PLD) specific for phosphatidylcholine (PtdCho) in proliferating cells and a phospholipase C (PLC) specific for phosphatidylethanolamine (PtdEtn) in retinoic acid (RA) differentiated cells. phosphatidylethanolamine 221-227 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 84-87 8663012-9 1996 However, none of the above phospholipids affected the Ha-Ras-stimulated B-Raf activity, whereas PI, PS, phosphatidylethanolamine, and phosphatidic acid inhibited the Rap1B-stimulated B-Raf activity. phosphatidylethanolamine 104-128 ras-related protein Rap-1b Bos taurus 166-171 8663012-9 1996 However, none of the above phospholipids affected the Ha-Ras-stimulated B-Raf activity, whereas PI, PS, phosphatidylethanolamine, and phosphatidic acid inhibited the Rap1B-stimulated B-Raf activity. phosphatidylethanolamine 104-128 B-Raf proto-oncogene, serine/threonine kinase Bos taurus 183-188 8808758-3 1996 Pretreatment of neutrophils with TNF-alpha caused a rapid increase in the incorporation of [1-14C]20:4(n-6) substrate into cellular phosphatidylinositol and phosphatidic acid and a slower rise in the incorporation into phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 243-267 tumor necrosis factor Homo sapiens 33-42 8626542-7 1996 In addition, the C2A domain of synaptotagmin IV cannot bind liposomes consisting of PS (or PI) and phosphatidylcholine, PC (or phosphatidylethanolamine, PE) (1:1, w/w), indicating that the binding to negatively charged phospholipids is inhibited by the presence of PC or PE. phosphatidylethanolamine 127-151 synaptotagmin 4 Homo sapiens 31-47 8839453-1 1996 Decreasing the size of the outer leaflet pool of phosphatidylethanolamine (PE) in the erythrocyte membrane by treatment of intact cells with either phospholipase A2, or trinitrobenzenesulphonic acid (TNBS), causes a corresponding decrease in Mg(2+)-ATPase activity as determined in their respective ghosts. phosphatidylethanolamine 75-77 phospholipase A2 group IB Homo sapiens 148-164 8769889-2 1996 In the present study, partially purified rat brain PLD was found to be activated by another PLD activator, RhoA, when PIP2, but not other acidic phospholipids, was included in vesicles comprising phosphatidylethanolamine (PE) and the PLD substrate phosphatidyicholine (PC) (PE/PC vesicles), demonstrating the absolute requirement of PIP2 for the RhoA-stimulated PLD activation, too. phosphatidylethanolamine 196-220 ras homolog family member A Rattus norvegicus 107-111 8769889-2 1996 In the present study, partially purified rat brain PLD was found to be activated by another PLD activator, RhoA, when PIP2, but not other acidic phospholipids, was included in vesicles comprising phosphatidylethanolamine (PE) and the PLD substrate phosphatidyicholine (PC) (PE/PC vesicles), demonstrating the absolute requirement of PIP2 for the RhoA-stimulated PLD activation, too. phosphatidylethanolamine 222-224 ras homolog family member A Rattus norvegicus 107-111 8766555-7 1996 The mercury-induced IgG1 response in (NZB x NZW)F1 and SJL mice was found to be polyclonal and autoantibodies against double-stranded (ds)DNA, IgG, collagen, cardiolipin, phosphatidylethanolamine as well as antibodies against the hapten trinitrophenol were produced. phosphatidylethanolamine 171-195 LOC105243590 Mus musculus 20-24 8662978-9 1996 Binding of SAP to type IV collagen was inhibited by both collagen IV and C1q but not by phosphatidylethanolamine or bovine serum albumin. phosphatidylethanolamine 88-112 amyloid P component, serum Homo sapiens 11-14 8670155-3 1996 When PE containing [14C]arachidonic acid in the sn-2 position ([14C]PAPE) is incorporated into BBC membranes, HDL3 stimulation induces the formation of PMME, PDME, PC and lyso-PC and the release of [14C]arachidonic acid, which correlates with the previous production of lyso-PC, suggesting that HDL3 stimulates a PLA2 that can release polyunsaturated fatty acids (PUFA). phosphatidylethanolamine 5-7 LOC104974671 Bos taurus 313-317 8808758-12 1996 These data collectively provide evidence that TNF-alpha specifically induces the turnover of neutrophil phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine, which are enriched with 20:4(n-6) by the activation of phospholipase A2. phosphatidylethanolamine 150-174 tumor necrosis factor Homo sapiens 46-55 8808758-12 1996 These data collectively provide evidence that TNF-alpha specifically induces the turnover of neutrophil phosphatidylinositol, phosphatidylcholine and phosphatidylethanolamine, which are enriched with 20:4(n-6) by the activation of phospholipase A2. phosphatidylethanolamine 150-174 phospholipase A2 group IB Homo sapiens 231-247 8681431-4 1996 Several cell types and tissues appear to express additional forms of PLD which can hydrolyze either phosphatidylethanolamine or phosphatidylinositol. phosphatidylethanolamine 100-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 69-72 8694509-1 1996 Phosphatidylethanolamine is converted to phosphatidylcholine in hepatocytes via the enzyme phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 0-24 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 91-135 8694509-1 1996 Phosphatidylethanolamine is converted to phosphatidylcholine in hepatocytes via the enzyme phosphatidylethanolamine N-methyltransferase (PEMT). phosphatidylethanolamine 0-24 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 137-141 8633059-0 1996 Mammalian phospholipase D: phosphatidylethanolamine as an essential component. phosphatidylethanolamine 27-51 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 10-25 9386267-2 1996 PEMT catalyzes the conversion of phosphatidylethanolamine to phosphatidylcholine in hepatocytes. phosphatidylethanolamine 33-57 phosphatidylethanolamine N-methyltransferase Rattus norvegicus 0-4 7577962-12 1995 Cholesterol and phosphatidylethanolamine together were found to be responsible for the greater MBP-mediated aggregation of Cyt.-LUVs and the greater TID labeling of MBP bound to Cyt.-LUVs compared to PC/acidic lipid LUVs. phosphatidylethanolamine 16-40 myelin basic protein Homo sapiens 95-98 8554523-7 1995 BK was also able to increase the release of [14C]ethanolamine, a water-soluble product of hydrolysis of phosphatidylethanolamine (PtdEtn), through PLD activation in young and old cells. phosphatidylethanolamine 104-128 kininogen 1 Homo sapiens 0-2 8554523-7 1995 BK was also able to increase the release of [14C]ethanolamine, a water-soluble product of hydrolysis of phosphatidylethanolamine (PtdEtn), through PLD activation in young and old cells. phosphatidylethanolamine 104-128 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 147-150 8554523-7 1995 BK was also able to increase the release of [14C]ethanolamine, a water-soluble product of hydrolysis of phosphatidylethanolamine (PtdEtn), through PLD activation in young and old cells. phosphatidylethanolamine 130-136 kininogen 1 Homo sapiens 0-2 8554523-7 1995 BK was also able to increase the release of [14C]ethanolamine, a water-soluble product of hydrolysis of phosphatidylethanolamine (PtdEtn), through PLD activation in young and old cells. phosphatidylethanolamine 130-136 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 147-150 7577962-12 1995 Cholesterol and phosphatidylethanolamine together were found to be responsible for the greater MBP-mediated aggregation of Cyt.-LUVs and the greater TID labeling of MBP bound to Cyt.-LUVs compared to PC/acidic lipid LUVs. phosphatidylethanolamine 16-40 myelin basic protein Homo sapiens 165-168 8578536-9 1995 Addition of pancreatic phospholipase A2 (PLA2) in doses sufficient to hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%. phosphatidylethanolamine 101-125 phospholipase A2 group IB Homo sapiens 23-39 7588730-4 1995 The activation of phosphoethanolamine cytidylyltransferase and ethanolamine phosphotransferase activities by OctMeGroPCho in vitro and increased production of CDP-ethanolamine suggest that stimulation of the above enzymes by OctMeGroPCho in the cells is responsible for the increased phosphatidylethanolamine synthesis. phosphatidylethanolamine 284-308 cut like homeobox 1 Homo sapiens 159-162 8578536-9 1995 Addition of pancreatic phospholipase A2 (PLA2) in doses sufficient to hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%. phosphatidylethanolamine 101-125 phospholipase A2 group IB Homo sapiens 41-45 8578536-9 1995 Addition of pancreatic phospholipase A2 (PLA2) in doses sufficient to hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%. phosphatidylethanolamine 127-129 phospholipase A2 group IB Homo sapiens 23-39 8578536-9 1995 Addition of pancreatic phospholipase A2 (PLA2) in doses sufficient to hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%. phosphatidylethanolamine 127-129 phospholipase A2 group IB Homo sapiens 41-45 8578536-10 1995 Doses of PLA2 that hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%. phosphatidylethanolamine 50-74 phospholipase A2 group IB Homo sapiens 9-13 8578536-10 1995 Doses of PLA2 that hydrolyze more than 95% of the phosphatidylethanolamine (PE) and 37% of the phosphatidylcholine (PC) decreased the binding by 50%. phosphatidylethanolamine 76-78 phospholipase A2 group IB Homo sapiens 9-13 8524695-6 1995 Decreased phosphatidylethanolamine, phosphatidylinositol and phosphatidylcholine levels were shown in patients before EPO treatment, compares with the control group. phosphatidylethanolamine 10-34 erythropoietin Homo sapiens 118-121 7591966-0 1995 Inostamycin, an inhibitor of P-glycoprotein function, interacts specifically with phosphatidylethanolamine. phosphatidylethanolamine 82-106 ATP binding cassette subfamily B member 1 Homo sapiens 29-43 7591966-6 1995 These results suggest that inostamycin can inhibit P-glycoprotein irreversibly by binding to plasma membranes irreversibly through phosphatidylethanolamine. phosphatidylethanolamine 131-155 ATP binding cassette subfamily B member 1 Homo sapiens 51-65 7480083-4 1995 The major long-chain polyunsaturated fatty acids (LC-PUFA), arachidonic acid (AA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), are found primarily in PC, PE, and PI. phosphatidylethanolamine 171-173 pumilio RNA binding family member 3 Homo sapiens 53-57 7542869-3 1995 We found that purified acute-phase SAA, but not the constitutive form, markedly enhances the lipolytic activity of sPLA2 in a dose-related manner with phosphatidylcholine/lysophosphatidylcholine or phosphatidylethanolamine/lysophosphatidylethanolamine liposomal substrates. phosphatidylethanolamine 198-222 serum amyloid A1 Homo sapiens 35-38 7542869-3 1995 We found that purified acute-phase SAA, but not the constitutive form, markedly enhances the lipolytic activity of sPLA2 in a dose-related manner with phosphatidylcholine/lysophosphatidylcholine or phosphatidylethanolamine/lysophosphatidylethanolamine liposomal substrates. phosphatidylethanolamine 198-222 phospholipase A2 group X Homo sapiens 115-120 7551686-3 1995 Plasma phospholipids demonstrated three distinct PAF inhibitory fractions in TLC regions corresponding to those of sphingomyelin, phosphatidylcholine and phosphatidylethanolamine. phosphatidylethanolamine 154-178 PCNA clamp associated factor Homo sapiens 49-52 21232251-6 1995 Specifically, the APC anticoagulant activity requires phosphatidylethanolamine, whereas the prothrombin activation complex does not. phosphatidylethanolamine 54-78 APC regulator of WNT signaling pathway Homo sapiens 18-21 21232251-7 1995 These observations may partially explain thrombotic complications with antiphospholipid antibodies in which the some antibodies have been shown to react preferentially with phosphatidylethanolamine and could, therefore, selectively block APC function. phosphatidylethanolamine 173-197 APC regulator of WNT signaling pathway Homo sapiens 238-241 7481876-5 1995 Digestion of cardiac SR isolated from control rats with phospholipase A2 inhibited 3H-ryanodine binding, which could be dramatically recovered by the incorporation of phosphatidylcholine (PC), or phosphatidylserine (PS), or phosphatidylethanolamine (PE) into the isolated cardiac SR. Incorporation of above phospolipids into SR isolated from septic rats reversed shock-induced inhibition of 3H-ryanodine binding. phosphatidylethanolamine 224-248 phospholipase A2 group IB Rattus norvegicus 56-72 7481876-5 1995 Digestion of cardiac SR isolated from control rats with phospholipase A2 inhibited 3H-ryanodine binding, which could be dramatically recovered by the incorporation of phosphatidylcholine (PC), or phosphatidylserine (PS), or phosphatidylethanolamine (PE) into the isolated cardiac SR. Incorporation of above phospolipids into SR isolated from septic rats reversed shock-induced inhibition of 3H-ryanodine binding. phosphatidylethanolamine 250-252 phospholipase A2 group IB Rattus norvegicus 56-72 7586010-3 1995 Treatment with chondroitin sulfate (CS)-PE at 10 micrograms/ml made laminin, fibronectin, vitronectin, and collagens type I-V less adhesive as substrates for cell attachment and inhibited cell spreading on these substrates. phosphatidylethanolamine 40-42 fibronectin 1 Rattus norvegicus 77-88 7631805-9 1995 This form of PLA2 exhibited a neutral and broad pH optimum (pH 6.0-8.0) and hydrolyzed both phosphatidylethanolamine and phosphatidylcholine effectively. phosphatidylethanolamine 92-116 phospholipase A2 group IB Homo sapiens 13-17 7586010-3 1995 Treatment with chondroitin sulfate (CS)-PE at 10 micrograms/ml made laminin, fibronectin, vitronectin, and collagens type I-V less adhesive as substrates for cell attachment and inhibited cell spreading on these substrates. phosphatidylethanolamine 40-42 vitronectin Rattus norvegicus 90-101 7566365-4 1995 The analysis of lipid composition showed a significant loss of phospholipids: among phospholipid species, sphingomyelin and phosphatidylethanolamine plasmalogen were particularly reduced by ET-1 treatment. phosphatidylethanolamine 124-148 endothelin 1 Rattus norvegicus 190-194 7857990-1 1995 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate (PMA) either inhibits or stimulates phospholipase C-mediated hydrolysis of phosphatidylethanolamine in the absence or presence of ethanol, respectively. phosphatidylethanolamine 149-173 proline rich transmembrane protein 2 Homo sapiens 20-36 9816008-10 1995 These results show that multilamellar vesicle muramyl tripeptide phosphatidylethanolamine administration activates monocyte cytotoxicity and cytokine production (TNF-alpha, IL-6). phosphatidylethanolamine 65-89 tumor necrosis factor Homo sapiens 162-171 9816008-10 1995 These results show that multilamellar vesicle muramyl tripeptide phosphatidylethanolamine administration activates monocyte cytotoxicity and cytokine production (TNF-alpha, IL-6). phosphatidylethanolamine 65-89 interleukin 6 Homo sapiens 173-177 7721742-3 1995 GTP gamma S-stimulated PLD activity was detected in the membranes when exogenous labeled phosphatidylcholine was used in the presence of phosphatidylethanolamine and phosphatidylinositol 4,5-bisphosphate, but not when [3H]myristic acid-labeled endogenous substrate was used. phosphatidylethanolamine 137-161 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 23-26 7896803-7 1995 Phosphatidylethanolamine present in the lipid vesicles potentiated 4 beta-12-O-tetradecanoylphorbol-13-acetate- and diacylglycerol-induced PKC activities, whereas 1,25-D3-induced activity decreased, consistent with 1,25-D3-activated PKC possessing a distinct conformation. phosphatidylethanolamine 0-24 protein kinase C alpha Homo sapiens 139-142 7896803-7 1995 Phosphatidylethanolamine present in the lipid vesicles potentiated 4 beta-12-O-tetradecanoylphorbol-13-acetate- and diacylglycerol-induced PKC activities, whereas 1,25-D3-induced activity decreased, consistent with 1,25-D3-activated PKC possessing a distinct conformation. phosphatidylethanolamine 0-24 protein kinase C alpha Homo sapiens 233-236 7890739-1 1995 Phosphatidylserine decarboxylase (PSD1) plays a central role in the biosynthesis of aminophospholipids in both prokaryotes and eukaryotes by catalyzing the synthesis of phosphatidylethanolamine. phosphatidylethanolamine 169-193 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 34-38 7890740-13 1995 Strains containing both the psd1-delta 1::TRP1 and psd2-delta 1::HIS3 null alleles, however, express no detectable PSD activity, are ethanolamine auxotrophs and show a severe deficit in the conversion of [3H]serine-labeled phosphatidylserine to phosphatidylethanolamine. phosphatidylethanolamine 245-269 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 28-32 7890740-13 1995 Strains containing both the psd1-delta 1::TRP1 and psd2-delta 1::HIS3 null alleles, however, express no detectable PSD activity, are ethanolamine auxotrophs and show a severe deficit in the conversion of [3H]serine-labeled phosphatidylserine to phosphatidylethanolamine. phosphatidylethanolamine 245-269 phosphatidylserine decarboxylase 2 Saccharomyces cerevisiae S288C 51-63 7875322-4 1995 In view of the known dependence of P-gp function on phosphatidylethanolamine (PtdEtn), inhibition of PtdEtn synthesis may represent an additional mechanism by which TAM inhibits P-gp-mediated drug efflux. phosphatidylethanolamine 52-76 ATP binding cassette subfamily B member 1 Homo sapiens 35-39 7875322-4 1995 In view of the known dependence of P-gp function on phosphatidylethanolamine (PtdEtn), inhibition of PtdEtn synthesis may represent an additional mechanism by which TAM inhibits P-gp-mediated drug efflux. phosphatidylethanolamine 78-84 ATP binding cassette subfamily B member 1 Homo sapiens 35-39 7875322-4 1995 In view of the known dependence of P-gp function on phosphatidylethanolamine (PtdEtn), inhibition of PtdEtn synthesis may represent an additional mechanism by which TAM inhibits P-gp-mediated drug efflux. phosphatidylethanolamine 101-107 ATP binding cassette subfamily B member 1 Homo sapiens 178-182 7857990-1 1995 In fibroblasts, the protein kinase C (PKC) activator phorbol 12-myristate (PMA) either inhibits or stimulates phospholipase C-mediated hydrolysis of phosphatidylethanolamine in the absence or presence of ethanol, respectively. phosphatidylethanolamine 149-173 proline rich transmembrane protein 2 Homo sapiens 38-41 7857307-4 1995 As a potent inhibitor of S-adenosylhomocysteine hydrolase, aristeromycin inhibited methylation of phosphatidylethanolamine to form phosphatidylcholine in K562 cells. phosphatidylethanolamine 98-122 adenosylhomocysteinase Homo sapiens 25-57 7853148-6 1994 The substrates of serine-exchange enzyme I are phosphatidylcholine, and either choline, serine, or ethanolamine, while those of serine-exchange enzyme II are phosphatidylethanolamine, and serine or ethanolamine but not choline. phosphatidylethanolamine 158-182 phosphatidylserine synthase 1 Homo sapiens 18-42 8725048-3 1995 The activity of phospholipase A2 (PLA2) was determined by monitoring 14C] arachidonate release using 14C] phosphatidylcholine (PC) or 14C] phosphatidylethanolamine (PE) as a substrate. phosphatidylethanolamine 139-163 phospholipase A2 group IB Rattus norvegicus 16-32 8725048-3 1995 The activity of phospholipase A2 (PLA2) was determined by monitoring 14C] arachidonate release using 14C] phosphatidylcholine (PC) or 14C] phosphatidylethanolamine (PE) as a substrate. phosphatidylethanolamine 139-163 phospholipase A2 group IB Rattus norvegicus 34-38 8725048-3 1995 The activity of phospholipase A2 (PLA2) was determined by monitoring 14C] arachidonate release using 14C] phosphatidylcholine (PC) or 14C] phosphatidylethanolamine (PE) as a substrate. phosphatidylethanolamine 165-167 phospholipase A2 group IB Rattus norvegicus 16-32 8725048-3 1995 The activity of phospholipase A2 (PLA2) was determined by monitoring 14C] arachidonate release using 14C] phosphatidylcholine (PC) or 14C] phosphatidylethanolamine (PE) as a substrate. phosphatidylethanolamine 165-167 phospholipase A2 group IB Rattus norvegicus 34-38 8725048-8 1995 These results indicate that the increased synthesis of eicosanoids by glomeruli from obstructed kidney may be mediated by enhanced activities of PE-specific PLA2 and PLC. phosphatidylethanolamine 145-147 phospholipase A2 group IB Rattus norvegicus 157-161 7769977-1 1995 Phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) were isolated from a Vibrio species of bacterium, known to produce eicosapentaenoic acid (20:5n-3) and trans-hexadecenoic acid (16:1n-7), and subjected to phospholipase A2 degradation to determine the positional distribution of component fatty acids. phosphatidylethanolamine 0-24 phospholipase A2 group IB Homo sapiens 215-231 7769977-1 1995 Phosphatidylethanolamine (PE) and phosphatidylglycerol (PG) were isolated from a Vibrio species of bacterium, known to produce eicosapentaenoic acid (20:5n-3) and trans-hexadecenoic acid (16:1n-7), and subjected to phospholipase A2 degradation to determine the positional distribution of component fatty acids. phosphatidylethanolamine 26-28 phospholipase A2 group IB Homo sapiens 215-231 7559741-6 1995 The purified P-glycoprotein was reconstituted by detergent dialysis into liposomes composed of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine. phosphatidylethanolamine 116-140 ATP binding cassette subfamily B member 1 Homo sapiens 13-27 8643029-1 1995 The compound 3-amino-1-propanol which replaces ethanolamine in phosphatidyl-ethanolamine and inhibits transformation of it, hindered insulin imprinting of Tetrahymena. phosphatidylethanolamine 63-88 insulin Homo sapiens 133-140 7989342-6 1994 Instead, CSF-1 enhanced the rate of exogenous arachidonic acid incorporation into phosphatidylcholine and its subsequent transfer to phosphatidylethanolamine suggesting that higher rates of arachidonic acid acylation may contribute to the suppression of prostaglandin production. phosphatidylethanolamine 133-157 colony stimulating factor 1 (macrophage) Mus musculus 9-14 7961831-2 1994 Incorporation of 32Pi into phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine in wild type and ept1 strains was decreased in the presence of exogenous inositol. phosphatidylethanolamine 48-72 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 114-118 7971987-7 1994 We conclude that the Mg2+ ATPase is sufficient for the biochemical expression of the aminophospholipid translocase activity, which is responsible for the inward transport of phosphatidylserine and phosphatidylethanolamine within the erythrocyte membrane. phosphatidylethanolamine 197-221 mucin 7, secreted Homo sapiens 21-24 7971987-7 1994 We conclude that the Mg2+ ATPase is sufficient for the biochemical expression of the aminophospholipid translocase activity, which is responsible for the inward transport of phosphatidylserine and phosphatidylethanolamine within the erythrocyte membrane. phosphatidylethanolamine 197-221 dynein axonemal heavy chain 8 Homo sapiens 26-32 7853148-6 1994 The substrates of serine-exchange enzyme I are phosphatidylcholine, and either choline, serine, or ethanolamine, while those of serine-exchange enzyme II are phosphatidylethanolamine, and serine or ethanolamine but not choline. phosphatidylethanolamine 158-182 phosphatidylserine synthase 2 Homo sapiens 128-153 7853148-7 1994 The last phosphatidylserine produced in consequence of the chain reaction again becomes a substrate of phosphatidylserine decarboxylase, and so this metabolic flow of the biosynthesis of phosphatidylserine is finally connected to a cyclic reaction between phosphatidylethanolamine and phosphatidylserine catalyzed by serine-exchange enzyme II and phosphatidylserine decarboxylase. phosphatidylethanolamine 256-280 phosphatidylserine synthase 2 Homo sapiens 317-342 7923374-3 1994 Molecular cloning, germline transformation, and biochemical experiments show that eas mutants are defective in the gene for ethanolamine kinase, which is required for a pathway of phosphatidylethanolamine synthesis. phosphatidylethanolamine 180-204 easily shocked Drosophila melanogaster 82-85 7923374-3 1994 Molecular cloning, germline transformation, and biochemical experiments show that eas mutants are defective in the gene for ethanolamine kinase, which is required for a pathway of phosphatidylethanolamine synthesis. phosphatidylethanolamine 180-204 easily shocked Drosophila melanogaster 124-143 7923374-4 1994 Assays of phospholipid composition reveal that total phosphatidylethanolamine is decreased in eas mutants. phosphatidylethanolamine 53-77 easily shocked Drosophila melanogaster 85-88 7944397-0 1994 Vitamin K3 preferentially inhibits stimulation of phospholipase D-mediated hydrolysis of phosphatidylethanolamine by protein kinase C activators in NIH 3T3 fibroblasts. phosphatidylethanolamine 89-113 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 50-65 7944397-4 1994 Of the two major substrates of PLD, phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), vitamin K3 (10-100 microM) preferentially inhibited PtdEtn hydrolysis when stimulated by PMA or platelet-derived growth factor, the latter being a hormonal activator of PKC. phosphatidylethanolamine 95-101 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 7944397-4 1994 Of the two major substrates of PLD, phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), vitamin K3 (10-100 microM) preferentially inhibited PtdEtn hydrolysis when stimulated by PMA or platelet-derived growth factor, the latter being a hormonal activator of PKC. phosphatidylethanolamine 156-162 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 31-34 7945230-5 1994 When phosphatidylethanolamine was used as substrate, only pancreatic PLA2 was inhibited. phosphatidylethanolamine 5-29 LOC104974671 Bos taurus 69-73 7945188-0 1994 Phorbol ester selectively stimulates the phospholipase D-mediated hydrolysis of phosphatidylethanolamine in multidrug-resistant MCF-7 human breast carcinoma cells. phosphatidylethanolamine 80-104 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 41-56 7945188-1 1994 The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells. phosphatidylethanolamine 100-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-19 7945188-1 1994 The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells. phosphatidylethanolamine 100-124 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 21-24 7945188-1 1994 The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells. phosphatidylethanolamine 126-132 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 4-19 7945188-1 1994 The phospholipase D (PLD)-mediated synthesis of phosphatidylethanol (PtdEtOH) and the hydrolysis of phosphatidylethanolamine (PtdEtn) and phosphatidylcholine (PtdCho) were examined in drug-sensitive and multidrug-resistant lines of MCF-7 human breast carcinoma cells. phosphatidylethanolamine 126-132 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 21-24 8053894-0 1994 Enhancement of thrombin-thrombomodulin-catalysed protein C activation by phosphatidylethanolamine containing unsaturated fatty acids: possible physiological significance of phosphatidylethanolamine in anticoagulant activity of thrombomodulin. phosphatidylethanolamine 73-97 coagulation factor II, thrombin Homo sapiens 15-23 8051052-10 1994 A plb1 delta mutant released wild-type levels of the soluble phosphatidylinositol metabolite glycerophosphoinositol into the growth medium but released greatly reduced levels of the corresponding phosphatidylcholine and phosphatidylethanolamine metabolites. phosphatidylethanolamine 220-244 lysophospholipase Saccharomyces cerevisiae S288C 2-6 8051052-11 1994 These results indicate that PLB1 is principally responsible for the production of the deacylation products of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol. phosphatidylethanolamine 134-158 lysophospholipase Saccharomyces cerevisiae S288C 28-32 8053894-0 1994 Enhancement of thrombin-thrombomodulin-catalysed protein C activation by phosphatidylethanolamine containing unsaturated fatty acids: possible physiological significance of phosphatidylethanolamine in anticoagulant activity of thrombomodulin. phosphatidylethanolamine 73-97 thrombomodulin Homo sapiens 24-38 8053894-0 1994 Enhancement of thrombin-thrombomodulin-catalysed protein C activation by phosphatidylethanolamine containing unsaturated fatty acids: possible physiological significance of phosphatidylethanolamine in anticoagulant activity of thrombomodulin. phosphatidylethanolamine 73-97 thrombomodulin Homo sapiens 227-241 8053894-0 1994 Enhancement of thrombin-thrombomodulin-catalysed protein C activation by phosphatidylethanolamine containing unsaturated fatty acids: possible physiological significance of phosphatidylethanolamine in anticoagulant activity of thrombomodulin. phosphatidylethanolamine 173-197 coagulation factor II, thrombin Homo sapiens 15-23 8053894-0 1994 Enhancement of thrombin-thrombomodulin-catalysed protein C activation by phosphatidylethanolamine containing unsaturated fatty acids: possible physiological significance of phosphatidylethanolamine in anticoagulant activity of thrombomodulin. phosphatidylethanolamine 173-197 thrombomodulin Homo sapiens 24-38 7841299-6 1994 However, a strong correlation was noted between a subset of aPL that reacted to phosphatidylethanolamine by hexagonal array assay and low PSF levels. phosphatidylethanolamine 80-104 insulin like growth factor binding protein 7 Homo sapiens 138-141 8053897-11 1994 Furthermore, the 110 kDa PLA2 releases the same molar ratios of AA from all major phospholipid subclasses, whereas Type I and Type II PLA2s show some specificity for phosphatidylethanolamine when these enzymes are incubated with a complex mammalian membrane substrate. phosphatidylethanolamine 166-190 phospholipase A2 group IB Homo sapiens 25-29 8053897-11 1994 Furthermore, the 110 kDa PLA2 releases the same molar ratios of AA from all major phospholipid subclasses, whereas Type I and Type II PLA2s show some specificity for phosphatidylethanolamine when these enzymes are incubated with a complex mammalian membrane substrate. phosphatidylethanolamine 166-190 phospholipase A2 group IIA Homo sapiens 134-139