PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 19950900-0 2010 Discovery of 4-[(2S)-2-{[4-(4-chlorophenoxy)phenoxy]methyl}-1-pyrrolidinyl]butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis. DG-051 90-96 leukotriene A4 hydrolase Homo sapiens 109-133 19950900-4 2010 As applied within the context of LTA(4)H inhibitor design, the chemistry team was able to design a potent compound 20 (DG-051) (K(d) = 26 nM) with high aqueous solubility (>30 mg/mL) and high oral bioavailability (>80% across species) that is currently undergoing clinical evaluation for the treatment of myocardial infarction and stroke. DG-051 119-125 leukotriene A4 hydrolase Homo sapiens 33-40 19819140-0 2009 Synthesis and structural assignment of two major metabolites of the LTA4H inhibitor DG-051. DG-051 84-90 leukotriene A4 hydrolase Homo sapiens 68-73