PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12220516-3	2002	Here, we characterized the unique effects of Mi(wh)-MITF on the expression of mast cell-related genes.	2-methyl-4-isothiazolin-3-one	45-47	melanogenesis associated transcription factor	Mus musculus	52-56
12220516-6	2002	On the other hand, the expression level of tryptophan hydroxylase gene was lower in Mi(wh)/Mi(wh) CMCs than in tg/tg CMCs, suggesting the inhibitory effect of Mi(wh)-MITF on the transactivation.	2-methyl-4-isothiazolin-3-one	84-86	melanogenesis associated transcription factor	Mus musculus	166-170
12196562-0	2002	In vitro neurotoxicity of methylisothiazolinone, a commonly used industrial and household biocide, proceeds via a zinc and extracellular signal-regulated kinase mitogen-activated protein kinase-dependent pathway.	2-methyl-4-isothiazolin-3-one	26-47	mitogen-activated protein kinase 1	Homo sapiens	123-160
11858772-5	2002	Recurrent MI is reduced by antiplatelet agents (aspirin in most patients) and by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.	2-methyl-4-isothiazolin-3-one	10-12	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	81-128
11588059-2	2001	Cultured mast cells (CMCs) of mi/mi genotype express abnormal MITF (mi-MITF), but CMCs of tg/tg genotype do not express any MITFs.	2-methyl-4-isothiazolin-3-one	30-32	melanocyte inducing transcription factor	Homo sapiens	62-66
11588059-2	2001	Cultured mast cells (CMCs) of mi/mi genotype express abnormal MITF (mi-MITF), but CMCs of tg/tg genotype do not express any MITFs.	2-methyl-4-isothiazolin-3-one	30-32	melanocyte inducing transcription factor	Homo sapiens	71-75
11684011-0	2001	Linkage of M-CSF signaling to Mitf, TFE3, and the osteoclast defect in Mitf(mi/mi) mice.	2-methyl-4-isothiazolin-3-one	76-78	colony stimulating factor 1 (macrophage)	Mus musculus	11-16
11684011-0	2001	Linkage of M-CSF signaling to Mitf, TFE3, and the osteoclast defect in Mitf(mi/mi) mice.	2-methyl-4-isothiazolin-3-one	76-78	melanogenesis associated transcription factor	Mus musculus	71-75
11684011-0	2001	Linkage of M-CSF signaling to Mitf, TFE3, and the osteoclast defect in Mitf(mi/mi) mice.	2-methyl-4-isothiazolin-3-one	79-81	colony stimulating factor 1 (macrophage)	Mus musculus	11-16
11684011-0	2001	Linkage of M-CSF signaling to Mitf, TFE3, and the osteoclast defect in Mitf(mi/mi) mice.	2-methyl-4-isothiazolin-3-one	79-81	melanogenesis associated transcription factor	Mus musculus	71-75
11684011-6	2001	Furthermore, an unphosphorylatable mutant at the MAPK consensus serine is specifically deficient in formation of multinucleated osteoclasts, mimicking the defect in Mitf(mi/mi) mice.	2-methyl-4-isothiazolin-3-one	141-143	melanogenesis associated transcription factor	Mus musculus	165-169
11520113-0	2001	Defects in the MITF(mi/mi) apical surface are associated with a failure of outer segment elongation.	2-methyl-4-isothiazolin-3-one	20-22	melanogenesis associated transcription factor	Mus musculus	15-19
11520113-0	2001	Defects in the MITF(mi/mi) apical surface are associated with a failure of outer segment elongation.	2-methyl-4-isothiazolin-3-one	23-25	melanogenesis associated transcription factor	Mus musculus	15-19
11520113-5	2001	The MITF(mi/mi)RPE basal surface was loosely organized and retained ezrin labelling which indicated some degree of differentiation.	2-methyl-4-isothiazolin-3-one	9-11	melanogenesis associated transcription factor	Mus musculus	4-8
11520113-5	2001	The MITF(mi/mi)RPE basal surface was loosely organized and retained ezrin labelling which indicated some degree of differentiation.	2-methyl-4-isothiazolin-3-one	12-14	melanogenesis associated transcription factor	Mus musculus	4-8
11440275-6	2001	RESULTS: The mean plasma adrenomedullin concentrations ( SD) in patients with pheochromocytoma (37.9 +/- 6pg/ml) were significantly higher (p<0.0001) than those in normal subjects (13.7 +/- 6.1 pg/mI) and patients with essential hypertension (22.5 +/- 9.lpg/ml).	2-methyl-4-isothiazolin-3-one	200-202	adrenomedullin	Homo sapiens	25-39
11342428-2	2001	Mast cells of mi/mi genotype express normal amounts of abnormal MITF (mi-MITF), whereas mast cells of tg/tg genotype do not express any MITFs.	2-methyl-4-isothiazolin-3-one	14-16	melanogenesis associated transcription factor	Mus musculus	64-68
11342428-5	2001	The NDST-2 mRNA was detected by in situ hybridization in the skin mast cells of +/+ and tg/tg mice, but not in the skin mast cells of mi/mi mice.	2-methyl-4-isothiazolin-3-one	94-96	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	4-10
11336184-7	2001	Persistent Mi (Alb+) was defined as an average albumin-to-creatinine ratio between 2.38 and 19 (men) and 2.96 and 20 (women).	2-methyl-4-isothiazolin-3-one	11-13	albumin	Homo sapiens	15-18
11264169-2	2001	Mast cells of mi/mi genotype express normal amount of abnormal MITF (mi-MITF), whereas mast cells of tg/tg genotype do not express any MITFs.	2-methyl-4-isothiazolin-3-one	14-16	melanogenesis associated transcription factor	Mus musculus	63-67
11264169-6	2001	The amounts of c-kit, granzyme B (Gr B), and tryptophan hydroxylase (TPH) messenger RNAs decreased in mast cells of mi(ce)/mi(ce) mice to levels comparable to those of tg/tg mice, and the amounts were intermediate between those of +/+ mice and those of mi/mi mice.	2-methyl-4-isothiazolin-3-one	116-118	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	15-20
11264169-6	2001	The amounts of c-kit, granzyme B (Gr B), and tryptophan hydroxylase (TPH) messenger RNAs decreased in mast cells of mi(ce)/mi(ce) mice to levels comparable to those of tg/tg mice, and the amounts were intermediate between those of +/+ mice and those of mi/mi mice.	2-methyl-4-isothiazolin-3-one	116-118	granzyme B	Mus musculus	34-38
11264169-6	2001	The amounts of c-kit, granzyme B (Gr B), and tryptophan hydroxylase (TPH) messenger RNAs decreased in mast cells of mi(ce)/mi(ce) mice to levels comparable to those of tg/tg mice, and the amounts were intermediate between those of +/+ mice and those of mi/mi mice.	2-methyl-4-isothiazolin-3-one	116-118	tryptophan hydroxylase 1	Mus musculus	45-67
11264169-6	2001	The amounts of c-kit, granzyme B (Gr B), and tryptophan hydroxylase (TPH) messenger RNAs decreased in mast cells of mi(ce)/mi(ce) mice to levels comparable to those of tg/tg mice, and the amounts were intermediate between those of +/+ mice and those of mi/mi mice.	2-methyl-4-isothiazolin-3-one	116-118	tryptophan hydroxylase 1	Mus musculus	69-72
11264169-6	2001	The amounts of c-kit, granzyme B (Gr B), and tryptophan hydroxylase (TPH) messenger RNAs decreased in mast cells of mi(ce)/mi(ce) mice to levels comparable to those of tg/tg mice, and the amounts were intermediate between those of +/+ mice and those of mi/mi mice.	2-methyl-4-isothiazolin-3-one	123-125	tryptophan hydroxylase 1	Mus musculus	45-67
11329759-12	2001	ACE inhibitors remain the drugs of choice for patients with heart failure, left ventricular dysfunction after MI, and diabetic nephropathy; ARBs offer these patients an alternative when ACE inhibitor therapy is not tolerated.	2-methyl-4-isothiazolin-3-one	110-112	angiotensin I converting enzyme	Homo sapiens	0-3
11264169-6	2001	The amounts of c-kit, granzyme B (Gr B), and tryptophan hydroxylase (TPH) messenger RNAs decreased in mast cells of mi(ce)/mi(ce) mice to levels comparable to those of tg/tg mice, and the amounts were intermediate between those of +/+ mice and those of mi/mi mice.	2-methyl-4-isothiazolin-3-one	123-125	tryptophan hydroxylase 1	Mus musculus	69-72
11264169-6	2001	The amounts of c-kit, granzyme B (Gr B), and tryptophan hydroxylase (TPH) messenger RNAs decreased in mast cells of mi(ce)/mi(ce) mice to levels comparable to those of tg/tg mice, and the amounts were intermediate between those of +/+ mice and those of mi/mi mice.	2-methyl-4-isothiazolin-3-one	123-125	tryptophan hydroxylase 1	Mus musculus	45-67
11264169-6	2001	The amounts of c-kit, granzyme B (Gr B), and tryptophan hydroxylase (TPH) messenger RNAs decreased in mast cells of mi(ce)/mi(ce) mice to levels comparable to those of tg/tg mice, and the amounts were intermediate between those of +/+ mice and those of mi/mi mice.	2-methyl-4-isothiazolin-3-one	123-125	tryptophan hydroxylase 1	Mus musculus	69-72
11264169-6	2001	The amounts of c-kit, granzyme B (Gr B), and tryptophan hydroxylase (TPH) messenger RNAs decreased in mast cells of mi(ce)/mi(ce) mice to levels comparable to those of tg/tg mice, and the amounts were intermediate between those of +/+ mice and those of mi/mi mice.	2-methyl-4-isothiazolin-3-one	123-125	tryptophan hydroxylase 1	Mus musculus	45-67
11264169-6	2001	The amounts of c-kit, granzyme B (Gr B), and tryptophan hydroxylase (TPH) messenger RNAs decreased in mast cells of mi(ce)/mi(ce) mice to levels comparable to those of tg/tg mice, and the amounts were intermediate between those of +/+ mice and those of mi/mi mice.	2-methyl-4-isothiazolin-3-one	123-125	tryptophan hydroxylase 1	Mus musculus	69-72
11306915-4	2001	The mi locus encodes a member of the basic helix-loop-helix-leucine zipper protein family of transcription factors (MITF), and mast cells of mi/mi mice showed phenotypic abnormalities.	2-methyl-4-isothiazolin-3-one	4-6	melanogenesis associated transcription factor	Mus musculus	116-120
11713892-8	2001	Thus, prominent beneficial cardiovascular effects of the additive short-term, high-dose GH to chronic high-dose ACE inhibition were obtained in rats with moderate MI, whereas little additional benefit or even detrimental effects of GH were found in rats with large MI.	2-methyl-4-isothiazolin-3-one	163-165	angiotensin I converting enzyme	Rattus norvegicus	112-115
11306915-4	2001	The mi locus encodes a member of the basic helix-loop-helix-leucine zipper protein family of transcription factors (MITF), and mast cells of mi/mi mice showed phenotypic abnormalities.	2-methyl-4-isothiazolin-3-one	85-87	melanogenesis associated transcription factor	Mus musculus	116-120
11035923-4	2000	We cocultured spleen cells prepared from either wild-type or mi/mi mice with ST2 or TM8 stromal cells and found that formation of TRAP-positive cells was significantly reduced in the cocultures of mi/mi spleen cells compared to wild-type spleen cells in the presence of 1,25(OH)(2) vitamin D(3) (vitamin D).	2-methyl-4-isothiazolin-3-one	64-66	interleukin 1 receptor-like 1	Mus musculus	77-80
11368304-5	2001	Furthermore, inhibitory effects of mi-Mi were shown not only on the DNA binding activity of wild-type Mi, but also on the nuclear translocation ability of Mi, PU.1 and cFOS.	2-methyl-4-isothiazolin-3-one	35-37	FBJ osteosarcoma oncogene	Mus musculus	168-172
11368304-5	2001	Furthermore, inhibitory effects of mi-Mi were shown not only on the DNA binding activity of wild-type Mi, but also on the nuclear translocation ability of Mi, PU.1 and cFOS.	2-methyl-4-isothiazolin-3-one	38-40	FBJ osteosarcoma oncogene	Mus musculus	168-172
11264174-2	2001	Mice of mi/mi genotype express a mutant form of MITF (mi-MITF), whereas mice of tg/tg genotype have a transgene in the 5" flanking region of the mi gene and do not express MITF.	2-methyl-4-isothiazolin-3-one	8-10	melanogenesis associated transcription factor	Mus musculus	48-52
11264174-2	2001	Mice of mi/mi genotype express a mutant form of MITF (mi-MITF), whereas mice of tg/tg genotype have a transgene in the 5" flanking region of the mi gene and do not express MITF.	2-methyl-4-isothiazolin-3-one	11-13	melanogenesis associated transcription factor	Mus musculus	48-52
11264174-6	2001	The difference between mi/mi and tg/tg mice was reproducible in the culture supplemented with interleukin-2.	2-methyl-4-isothiazolin-3-one	23-25	interleukin 2	Mus musculus	94-107
11264174-6	2001	The difference between mi/mi and tg/tg mice was reproducible in the culture supplemented with interleukin-2.	2-methyl-4-isothiazolin-3-one	26-28	interleukin 2	Mus musculus	94-107
11264174-13	2001	This inhibitory effect of mi-MITF may cause the deficient cytotoxicity of NK cells in mi/mi mice.	2-methyl-4-isothiazolin-3-one	86-88	melanogenesis associated transcription factor	Mus musculus	26-33
11035923-4	2000	We cocultured spleen cells prepared from either wild-type or mi/mi mice with ST2 or TM8 stromal cells and found that formation of TRAP-positive cells was significantly reduced in the cocultures of mi/mi spleen cells compared to wild-type spleen cells in the presence of 1,25(OH)(2) vitamin D(3) (vitamin D).	2-methyl-4-isothiazolin-3-one	61-63	interleukin 1 receptor-like 1	Mus musculus	77-80
11035923-4	2000	We cocultured spleen cells prepared from either wild-type or mi/mi mice with ST2 or TM8 stromal cells and found that formation of TRAP-positive cells was significantly reduced in the cocultures of mi/mi spleen cells compared to wild-type spleen cells in the presence of 1,25(OH)(2) vitamin D(3) (vitamin D).	2-methyl-4-isothiazolin-3-one	64-66	interleukin 1 receptor-like 1	Mus musculus	77-80
11035923-4	2000	We cocultured spleen cells prepared from either wild-type or mi/mi mice with ST2 or TM8 stromal cells and found that formation of TRAP-positive cells was significantly reduced in the cocultures of mi/mi spleen cells compared to wild-type spleen cells in the presence of 1,25(OH)(2) vitamin D(3) (vitamin D).	2-methyl-4-isothiazolin-3-one	64-66	interleukin 1 receptor-like 1	Mus musculus	77-80
10551593-13	1999	In parallel to the attenuated pressure increase, thromboxane A2 release was significantly suppressed in the 260-microg/l (200 +/- 220 pmol x ml(-1) x min(-1); P < 0.01) and 500-microg/l (285 +/- 70 pmol x m(-1) x min(-1); P < 0.05) PAP groups compared with controls (1,138 +/- 800 pmol x ml(-1) x mi(-1)).	2-methyl-4-isothiazolin-3-one	112-114	regenerating family member 3 beta	Rattus norvegicus	238-241
10750559-8	2000	Expression of a TRAP promoter-green fluorescent protein (GFP) transgene mimicked the expression of the endogenous TRAP gene during differentiation of osteoclast-like cells, and the expression of the transgene was decreased 8-fold when placed into the mutant mi/mi background.	2-methyl-4-isothiazolin-3-one	72-74	acid phosphatase 5, tartrate resistant	Mus musculus	16-20
10750559-8	2000	Expression of a TRAP promoter-green fluorescent protein (GFP) transgene mimicked the expression of the endogenous TRAP gene during differentiation of osteoclast-like cells, and the expression of the transgene was decreased 8-fold when placed into the mutant mi/mi background.	2-methyl-4-isothiazolin-3-one	72-74	acid phosphatase 5, tartrate resistant	Mus musculus	114-118
10101174-6	1999	Significant reductions of mI and mII inclusion were also observed in heterozygotes for loss-of-function alleles of virilizer, fl(2)d, and crooked neck.	2-methyl-4-isothiazolin-3-one	26-28	female lethal d	Drosophila melanogaster	126-132
10416701-0	1999	An update of the risk assessment for methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) with focus on rinse-off products.	2-methyl-4-isothiazolin-3-one	65-86	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	88-91
10416701-1	1999	Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) has been widely used during the last 20 years for the preservation of aqueous systems in cosmetics, toiletries and in various industrial applications.	2-methyl-4-isothiazolin-3-one	28-49	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	51-54
10361115-0	1999	Different effect of various mutant MITF encoded by mi, Mior, or Miwh allele on phenotype of murine mast cells.	2-methyl-4-isothiazolin-3-one	51-53	melanogenesis associated transcription factor	Mus musculus	35-39
10068667-2	1999	We reported that expression of the mouse mast cell protease 5 (MMCP-5) and MMCP-6 genes were deficient in cultured mast cells (CMC) derived from mutant mice of mi/mi genotype.	2-methyl-4-isothiazolin-3-one	152-154	chymase 1, mast cell	Mus musculus	41-61
10068667-2	1999	We reported that expression of the mouse mast cell protease 5 (MMCP-5) and MMCP-6 genes were deficient in cultured mast cells (CMC) derived from mutant mice of mi/mi genotype.	2-methyl-4-isothiazolin-3-one	152-154	chymase 1, mast cell	Mus musculus	63-69
10068667-2	1999	We reported that expression of the mouse mast cell protease 5 (MMCP-5) and MMCP-6 genes were deficient in cultured mast cells (CMC) derived from mutant mice of mi/mi genotype.	2-methyl-4-isothiazolin-3-one	152-154	tryptase beta 2	Mus musculus	75-81
10068667-2	1999	We reported that expression of the mouse mast cell protease 5 (MMCP-5) and MMCP-6 genes were deficient in cultured mast cells (CMC) derived from mutant mice of mi/mi genotype.	2-methyl-4-isothiazolin-3-one	160-162	chymase 1, mast cell	Mus musculus	41-61
10068667-2	1999	We reported that expression of the mouse mast cell protease 5 (MMCP-5) and MMCP-6 genes were deficient in cultured mast cells (CMC) derived from mutant mice of mi/mi genotype.	2-methyl-4-isothiazolin-3-one	160-162	chymase 1, mast cell	Mus musculus	63-69
10068667-2	1999	We reported that expression of the mouse mast cell protease 5 (MMCP-5) and MMCP-6 genes were deficient in cultured mast cells (CMC) derived from mutant mice of mi/mi genotype.	2-methyl-4-isothiazolin-3-one	160-162	tryptase beta 2	Mus musculus	75-81
9949161-9	1999	On the other hand, the transcription of three genes encoding c-kit receptor, tryptophan hydroxylase, and granzyme B was markedly reduced in mi/mi CMCs, but the reduction was significantly smaller in tg/tg CMCs.	2-methyl-4-isothiazolin-3-one	140-142	granzyme B	Mus musculus	105-115
9949161-9	1999	On the other hand, the transcription of three genes encoding c-kit receptor, tryptophan hydroxylase, and granzyme B was markedly reduced in mi/mi CMCs, but the reduction was significantly smaller in tg/tg CMCs.	2-methyl-4-isothiazolin-3-one	143-145	granzyme B	Mus musculus	105-115
9819381-2	1998	Mi has been shown to activate transcription of the tyrosinase, TRP-1, TRP-2, and QNR-71 genes through specific E-box elements, most notably the highly conserved M box.	2-methyl-4-isothiazolin-3-one	0-2	tyrosinase	Homo sapiens	51-61
9884389-1	1999	BACKGROUND: Recombinant human growth hormone (GH) improves in vivo cardiac function in rats with postinfarction heart failure (MI).	2-methyl-4-isothiazolin-3-one	127-129	growth hormone 1	Homo sapiens	30-44
9884389-10	1999	Left ventricular myocyte expression of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA-2) and left ventricular SERCA-2 protein levels were increased in MI+GH compared with MI rats.	2-methyl-4-isothiazolin-3-one	148-150	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	77-84
9884389-10	1999	Left ventricular myocyte expression of sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA-2) and left ventricular SERCA-2 protein levels were increased in MI+GH compared with MI rats.	2-methyl-4-isothiazolin-3-one	148-150	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Rattus norvegicus	107-114
9819381-2	1998	Mi has been shown to activate transcription of the tyrosinase, TRP-1, TRP-2, and QNR-71 genes through specific E-box elements, most notably the highly conserved M box.	2-methyl-4-isothiazolin-3-one	0-2	tRNA-Pro (anticodon AGG) 2-5	Homo sapiens	63-68
9819381-2	1998	Mi has been shown to activate transcription of the tyrosinase, TRP-1, TRP-2, and QNR-71 genes through specific E-box elements, most notably the highly conserved M box.	2-methyl-4-isothiazolin-3-one	0-2	tRNA-Pro (anticodon AGG) 2-6	Homo sapiens	70-75
9731055-0	1998	Impaired expression of integrin alpha-4 subunit in cultured mast cells derived from mutant mice of mi/mi genotype.	2-methyl-4-isothiazolin-3-one	91-93	integrin alpha 4	Mus musculus	23-39
9731055-0	1998	Impaired expression of integrin alpha-4 subunit in cultured mast cells derived from mutant mice of mi/mi genotype.	2-methyl-4-isothiazolin-3-one	99-101	integrin alpha 4	Mus musculus	23-39
7828669-4	1995	We found that serum levels of M-CSF in mi/mi mice were not significantly different from normal control mice.	2-methyl-4-isothiazolin-3-one	39-41	colony stimulating factor 1 (macrophage)	Mus musculus	30-35
9620911-4	1998	In contrast, after IL-4 inhalation, methacholine PC20 fell from baseline (0.43 +/- 1.81 mg/mI) to 0.22 +/- 1.73 mg/mI (p < 0.01) at 24 h, and to 0.21 +/- 1.	2-methyl-4-isothiazolin-3-one	91-93	interleukin 4	Homo sapiens	19-23
9620911-4	1998	In contrast, after IL-4 inhalation, methacholine PC20 fell from baseline (0.43 +/- 1.81 mg/mI) to 0.22 +/- 1.73 mg/mI (p < 0.01) at 24 h, and to 0.21 +/- 1.	2-methyl-4-isothiazolin-3-one	115-117	interleukin 4	Homo sapiens	19-23
9558376-2	1998	We have reported that the expression of several genes was impaired in cultured mast cells (CMCs) of mi/mi genotype, and demonstrated the involvement of MITF in the transcription of these genes.	2-methyl-4-isothiazolin-3-one	100-102	melanocyte inducing transcription factor	Homo sapiens	152-156
9558376-2	1998	We have reported that the expression of several genes was impaired in cultured mast cells (CMCs) of mi/mi genotype, and demonstrated the involvement of MITF in the transcription of these genes.	2-methyl-4-isothiazolin-3-one	103-105	melanocyte inducing transcription factor	Homo sapiens	152-156
9558376-9	1998	The introduction of +-MITF but not of mi-MITF normalized the serotonin content in mi/mi CMCs.	2-methyl-4-isothiazolin-3-one	82-84	melanocyte inducing transcription factor	Homo sapiens	22-26
9327738-7	1997	The mutant mi allele represents a deletion of an arginine at the basic domain of MITF.	2-methyl-4-isothiazolin-3-one	11-13	melanogenesis associated transcription factor	Mus musculus	81-85
9113372-9	1997	At 1 week after MI, circulating plasma levels of adrenaline, angiotensin II, atrial natriuretic factor (ANF) and vasopressin were significantly elevated.	2-methyl-4-isothiazolin-3-one	16-18	angiotensinogen	Rattus norvegicus	61-75
9113372-9	1997	At 1 week after MI, circulating plasma levels of adrenaline, angiotensin II, atrial natriuretic factor (ANF) and vasopressin were significantly elevated.	2-methyl-4-isothiazolin-3-one	16-18	natriuretic peptide A	Rattus norvegicus	77-102
9113372-9	1997	At 1 week after MI, circulating plasma levels of adrenaline, angiotensin II, atrial natriuretic factor (ANF) and vasopressin were significantly elevated.	2-methyl-4-isothiazolin-3-one	16-18	natriuretic peptide A	Rattus norvegicus	104-107
9113372-9	1997	At 1 week after MI, circulating plasma levels of adrenaline, angiotensin II, atrial natriuretic factor (ANF) and vasopressin were significantly elevated.	2-methyl-4-isothiazolin-3-one	16-18	arginine vasopressin	Rattus norvegicus	113-124
8881764-0	1996	A defect in inducible beta-galactosidase of B lymphocytes in the osteopetrotic (mi/mi) mouse.	2-methyl-4-isothiazolin-3-one	80-82	galactosidase, beta 1	Mus musculus	22-40
8881764-0	1996	A defect in inducible beta-galactosidase of B lymphocytes in the osteopetrotic (mi/mi) mouse.	2-methyl-4-isothiazolin-3-one	83-85	galactosidase, beta 1	Mus musculus	22-40
8881764-4	1996	Lyso-Pc-inducible beta-galactosidase of B lymphocytes was found to be defective in mi mutant mice.	2-methyl-4-isothiazolin-3-one	83-85	galactosidase, beta 1	Mus musculus	18-36
9326226-2	1997	Cultured mast cells (CMCs) of mi/mi genotype showed a poor response to nerve growth factor (NGF).	2-methyl-4-isothiazolin-3-one	30-32	nerve growth factor	Mus musculus	92-95
9326226-2	1997	Cultured mast cells (CMCs) of mi/mi genotype showed a poor response to nerve growth factor (NGF).	2-methyl-4-isothiazolin-3-one	33-35	nerve growth factor	Mus musculus	92-95
9326226-6	1997	The poor response of mi/mi CMCs to NGF was attributed to the deficient expression of p75 NGF receptor.	2-methyl-4-isothiazolin-3-one	21-23	nerve growth factor	Mus musculus	35-38
9326226-6	1997	The poor response of mi/mi CMCs to NGF was attributed to the deficient expression of p75 NGF receptor.	2-methyl-4-isothiazolin-3-one	21-23	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	85-88
9326226-6	1997	The poor response of mi/mi CMCs to NGF was attributed to the deficient expression of p75 NGF receptor.	2-methyl-4-isothiazolin-3-one	21-23	nerve growth factor	Mus musculus	89-92
9326226-6	1997	The poor response of mi/mi CMCs to NGF was attributed to the deficient expression of p75 NGF receptor.	2-methyl-4-isothiazolin-3-one	24-26	nerve growth factor	Mus musculus	35-38
9326226-6	1997	The poor response of mi/mi CMCs to NGF was attributed to the deficient expression of p75 NGF receptor.	2-methyl-4-isothiazolin-3-one	24-26	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	85-88
9326226-6	1997	The poor response of mi/mi CMCs to NGF was attributed to the deficient expression of p75 NGF receptor.	2-methyl-4-isothiazolin-3-one	24-26	nerve growth factor	Mus musculus	89-92
9326226-9	1997	Overexpression of +-MITF but not of mi-MITF normalized the expression of p75 and the above-mentioned poor responses of mi/mi CMCs to NGF, indicating the involvement of +-MITF in p75 gene transactivation.	2-methyl-4-isothiazolin-3-one	119-121	melanogenesis associated transcription factor	Mus musculus	20-24
9352446-6	1997	Rhodopsin regeneration experiments indicated that rhodopsin levels following 0,1,2 and 4 h dark-recovery were significantly less in mi(vit)/mi(vit) mutants compared with controls.	2-methyl-4-isothiazolin-3-one	132-134	rhodopsin	Mus musculus	0-9
9352446-6	1997	Rhodopsin regeneration experiments indicated that rhodopsin levels following 0,1,2 and 4 h dark-recovery were significantly less in mi(vit)/mi(vit) mutants compared with controls.	2-methyl-4-isothiazolin-3-one	132-134	rhodopsin	Mus musculus	50-59
9352446-6	1997	Rhodopsin regeneration experiments indicated that rhodopsin levels following 0,1,2 and 4 h dark-recovery were significantly less in mi(vit)/mi(vit) mutants compared with controls.	2-methyl-4-isothiazolin-3-one	140-142	rhodopsin	Mus musculus	0-9
9352446-6	1997	Rhodopsin regeneration experiments indicated that rhodopsin levels following 0,1,2 and 4 h dark-recovery were significantly less in mi(vit)/mi(vit) mutants compared with controls.	2-methyl-4-isothiazolin-3-one	140-142	rhodopsin	Mus musculus	50-59
9352446-9	1997	The data suggest that regeneration of rhodopsin is reduced by 4 weeks postnatally in the mi(vit)/mi(vit) mouse.	2-methyl-4-isothiazolin-3-one	89-91	rhodopsin	Mus musculus	38-47
9352446-9	1997	The data suggest that regeneration of rhodopsin is reduced by 4 weeks postnatally in the mi(vit)/mi(vit) mouse.	2-methyl-4-isothiazolin-3-one	97-99	rhodopsin	Mus musculus	38-47
9223672-3	1997	The minimal activation region of Mi is highly conserved in the related transcription factor TFE3 and is predicted to adopt an amphipathic alpha-helical conformation.	2-methyl-4-isothiazolin-3-one	33-35	transcription factor E3	Mus musculus	92-96
9223672-4	1997	This region of Mi is also highly conserved with a region of E1A known to be essential for binding the CBP/p300 transcription cofactor.	2-methyl-4-isothiazolin-3-one	15-17	CREB binding protein	Mus musculus	102-105
9223672-4	1997	This region of Mi is also highly conserved with a region of E1A known to be essential for binding the CBP/p300 transcription cofactor.	2-methyl-4-isothiazolin-3-one	15-17	E1A binding protein p300	Mus musculus	106-110
9223672-5	1997	Consistent with these observations, the Mi activation domain can interact in vitro with CBP specifically through a region of CBP required for complex formation with E1A, P/CAF and c-Fos, and anti p300 antibodies can co-immunoprecipitate Mi from both melanocyte and melanoma cell lines.	2-methyl-4-isothiazolin-3-one	40-42	CREB binding protein	Mus musculus	88-91
9223672-5	1997	Consistent with these observations, the Mi activation domain can interact in vitro with CBP specifically through a region of CBP required for complex formation with E1A, P/CAF and c-Fos, and anti p300 antibodies can co-immunoprecipitate Mi from both melanocyte and melanoma cell lines.	2-methyl-4-isothiazolin-3-one	40-42	CREB binding protein	Mus musculus	125-128
9223672-5	1997	Consistent with these observations, the Mi activation domain can interact in vitro with CBP specifically through a region of CBP required for complex formation with E1A, P/CAF and c-Fos, and anti p300 antibodies can co-immunoprecipitate Mi from both melanocyte and melanoma cell lines.	2-methyl-4-isothiazolin-3-one	40-42	K(lysine) acetyltransferase 2B	Mus musculus	170-175
9223672-5	1997	Consistent with these observations, the Mi activation domain can interact in vitro with CBP specifically through a region of CBP required for complex formation with E1A, P/CAF and c-Fos, and anti p300 antibodies can co-immunoprecipitate Mi from both melanocyte and melanoma cell lines.	2-methyl-4-isothiazolin-3-one	40-42	FBJ osteosarcoma oncogene	Mus musculus	180-185
9223672-5	1997	Consistent with these observations, the Mi activation domain can interact in vitro with CBP specifically through a region of CBP required for complex formation with E1A, P/CAF and c-Fos, and anti p300 antibodies can co-immunoprecipitate Mi from both melanocyte and melanoma cell lines.	2-methyl-4-isothiazolin-3-one	40-42	E1A binding protein p300	Mus musculus	196-200
9223672-5	1997	Consistent with these observations, the Mi activation domain can interact in vitro with CBP specifically through a region of CBP required for complex formation with E1A, P/CAF and c-Fos, and anti p300 antibodies can co-immunoprecipitate Mi from both melanocyte and melanoma cell lines.	2-methyl-4-isothiazolin-3-one	237-239	CREB binding protein	Mus musculus	88-91
9223672-5	1997	Consistent with these observations, the Mi activation domain can interact in vitro with CBP specifically through a region of CBP required for complex formation with E1A, P/CAF and c-Fos, and anti p300 antibodies can co-immunoprecipitate Mi from both melanocyte and melanoma cell lines.	2-methyl-4-isothiazolin-3-one	237-239	CREB binding protein	Mus musculus	125-128
9223672-5	1997	Consistent with these observations, the Mi activation domain can interact in vitro with CBP specifically through a region of CBP required for complex formation with E1A, P/CAF and c-Fos, and anti p300 antibodies can co-immunoprecipitate Mi from both melanocyte and melanoma cell lines.	2-methyl-4-isothiazolin-3-one	237-239	K(lysine) acetyltransferase 2B	Mus musculus	170-175
9223672-5	1997	Consistent with these observations, the Mi activation domain can interact in vitro with CBP specifically through a region of CBP required for complex formation with E1A, P/CAF and c-Fos, and anti p300 antibodies can co-immunoprecipitate Mi from both melanocyte and melanoma cell lines.	2-methyl-4-isothiazolin-3-one	237-239	FBJ osteosarcoma oncogene	Mus musculus	180-185
9223672-5	1997	Consistent with these observations, the Mi activation domain can interact in vitro with CBP specifically through a region of CBP required for complex formation with E1A, P/CAF and c-Fos, and anti p300 antibodies can co-immunoprecipitate Mi from both melanocyte and melanoma cell lines.	2-methyl-4-isothiazolin-3-one	237-239	E1A binding protein p300	Mus musculus	196-200
9223672-6	1997	In addition, co-transfection of a vector expressing CBP2 (aas 1621-1891) fused to the VP16 activation domain potentiated the ability of Mi to activate transcription, confirming the significance of the CBP-Mi interaction observed in vitro.	2-methyl-4-isothiazolin-3-one	136-138	serine (or cysteine) peptidase inhibitor, clade H, member 1	Mus musculus	52-56
9223672-6	1997	In addition, co-transfection of a vector expressing CBP2 (aas 1621-1891) fused to the VP16 activation domain potentiated the ability of Mi to activate transcription, confirming the significance of the CBP-Mi interaction observed in vitro.	2-methyl-4-isothiazolin-3-one	136-138	CREB binding protein	Mus musculus	52-55
9223672-7	1997	These data suggest that transcription activation by Mi is achieved at least in part by recruitment of CBP.	2-methyl-4-isothiazolin-3-one	52-54	CREB binding protein	Mus musculus	102-105
8916143-6	1996	Osn and Osc mRNA, which localized in osteoblasts and odontoblasts, were also detected in the cells of odontoma-like masses in mi/mi mice.	2-methyl-4-isothiazolin-3-one	126-128	secreted acidic cysteine rich glycoprotein	Mus musculus	0-3
8916143-6	1996	Osn and Osc mRNA, which localized in osteoblasts and odontoblasts, were also detected in the cells of odontoma-like masses in mi/mi mice.	2-methyl-4-isothiazolin-3-one	126-128	bone gamma-carboxyglutamate protein 2	Mus musculus	8-11
8916143-6	1996	Osn and Osc mRNA, which localized in osteoblasts and odontoblasts, were also detected in the cells of odontoma-like masses in mi/mi mice.	2-methyl-4-isothiazolin-3-one	129-131	secreted acidic cysteine rich glycoprotein	Mus musculus	0-3
8916143-6	1996	Osn and Osc mRNA, which localized in osteoblasts and odontoblasts, were also detected in the cells of odontoma-like masses in mi/mi mice.	2-methyl-4-isothiazolin-3-one	129-131	bone gamma-carboxyglutamate protein 2	Mus musculus	8-11
8558432-1	1996	The toxicity of 3-methylindole (3 MI), a selective pneumotoxin, is dependent upon cytochrome P450-mediated bioactivation 3.	2-methyl-4-isothiazolin-3-one	34-36	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	93-97
8558432-9	1996	The toxicity of 3 MI is believed to be due to covalent binding of a P450-generated intermediate to critical pulmonary proteins.	2-methyl-4-isothiazolin-3-one	18-20	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	68-72
8558432-11	1996	This study showed that the methylene imine electrophile is produced by only a few P450 enzymes and is the metabolite responsible for the covalent binding and presumably, the toxicity of 3 MI.	2-methyl-4-isothiazolin-3-one	188-190	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	82-86
8572854-6	1995	This index was correlated significantly to A/E (r = 0.74; p < 0.001) and to LV mi (r = -0.32; p < 0.05 only in HTA.	2-methyl-4-isothiazolin-3-one	82-84	hepatocellular carcinoma associated transcript 5	Homo sapiens	117-120
7484288-4	1995	However, administration of PTHrP (3 micrograms/h x 24 h) further stimulated enzyme activity in mi mutants with active disease, to a level no different than that in treated normals.	2-methyl-4-isothiazolin-3-one	11-13	parathyroid hormone-like peptide	Mus musculus	27-32
7484288-5	1995	Serum phosphorus levels also declined in mi/mi mice following PTHrP, suggesting a normal renal response to this hormone.	2-methyl-4-isothiazolin-3-one	41-43	parathyroid hormone-like peptide	Mus musculus	62-67
7484288-5	1995	Serum phosphorus levels also declined in mi/mi mice following PTHrP, suggesting a normal renal response to this hormone.	2-methyl-4-isothiazolin-3-one	44-46	parathyroid hormone-like peptide	Mus musculus	62-67
7828669-4	1995	We found that serum levels of M-CSF in mi/mi mice were not significantly different from normal control mice.	2-methyl-4-isothiazolin-3-one	42-44	colony stimulating factor 1 (macrophage)	Mus musculus	30-35
7828669-6	1995	In spleen cells from mi/mi mice, the receptor binding sites per cell (normalized to total spleen cells, M-CSF receptor positive cells, or M-CSF receptor RNA positive cells) were present in a greater number than in spleen cells from phenotypically normal siblings.	2-methyl-4-isothiazolin-3-one	21-23	colony stimulating factor 1 (macrophage)	Mus musculus	104-109
7828669-6	1995	In spleen cells from mi/mi mice, the receptor binding sites per cell (normalized to total spleen cells, M-CSF receptor positive cells, or M-CSF receptor RNA positive cells) were present in a greater number than in spleen cells from phenotypically normal siblings.	2-methyl-4-isothiazolin-3-one	21-23	colony stimulating factor 1 (macrophage)	Mus musculus	138-143
7828669-6	1995	In spleen cells from mi/mi mice, the receptor binding sites per cell (normalized to total spleen cells, M-CSF receptor positive cells, or M-CSF receptor RNA positive cells) were present in a greater number than in spleen cells from phenotypically normal siblings.	2-methyl-4-isothiazolin-3-one	24-26	colony stimulating factor 1 (macrophage)	Mus musculus	104-109
7828669-6	1995	In spleen cells from mi/mi mice, the receptor binding sites per cell (normalized to total spleen cells, M-CSF receptor positive cells, or M-CSF receptor RNA positive cells) were present in a greater number than in spleen cells from phenotypically normal siblings.	2-methyl-4-isothiazolin-3-one	24-26	colony stimulating factor 1 (macrophage)	Mus musculus	138-143
7517699-3	1994	Since c-kit receptor tyrosine kinase is the gene product of the W locus and mi mutation has been suggested to affect the transduction of signals from the c-kit and c-fms receptors, we here examined the effect of mi mutation on fertility.	2-methyl-4-isothiazolin-3-one	76-78	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	154-159
7824265-7	1995	Moreover, expression of the mi gene was reduced around 50-fold in the non-pigmented E1a-transformed melan-a cells compared to the nontransformed melan-a cell line, with ectopic expression of Mi able to prevent repression of the tyrosinase and TRP-1 promoters in the presence of E1A.	2-methyl-4-isothiazolin-3-one	191-193	tyrosinase	Homo sapiens	228-238
7824265-7	1995	Moreover, expression of the mi gene was reduced around 50-fold in the non-pigmented E1a-transformed melan-a cells compared to the nontransformed melan-a cell line, with ectopic expression of Mi able to prevent repression of the tyrosinase and TRP-1 promoters in the presence of E1A.	2-methyl-4-isothiazolin-3-one	191-193	tyrosinase related protein 1	Homo sapiens	243-248
7524763-0	1994	Poor response of cultured mast cells derived from mi/mi mutant mice to nerve growth factor.	2-methyl-4-isothiazolin-3-one	50-52	nerve growth factor	Mus musculus	71-90
7524763-0	1994	Poor response of cultured mast cells derived from mi/mi mutant mice to nerve growth factor.	2-methyl-4-isothiazolin-3-one	53-55	nerve growth factor	Mus musculus	71-90
7524763-10	1994	Taken together, the poor response of mi/mi CMCs to NGF appeared to be attributable to the impaired transcription of the p75 gene.	2-methyl-4-isothiazolin-3-one	37-39	nerve growth factor	Mus musculus	51-54
7524763-10	1994	Taken together, the poor response of mi/mi CMCs to NGF appeared to be attributable to the impaired transcription of the p75 gene.	2-methyl-4-isothiazolin-3-one	37-39	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	120-123
7524330-0	1994	Cell type-specific deficiency of c-kit gene expression in mutant mice of mi/mi genotype.	2-methyl-4-isothiazolin-3-one	65-67	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	33-38
7524330-0	1994	Cell type-specific deficiency of c-kit gene expression in mutant mice of mi/mi genotype.	2-methyl-4-isothiazolin-3-one	73-75	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	33-38
7524330-3	1994	Since the c-kit receptor tyrosine kinase plays an important role in the development of mast cells, and since the c-kit expression by cultured mast cells from mi/mi mice is deficient in both mRNA and protein levels, the mast cell deficiency of mi/mi mice has been attributed at least in part to the deficient expression of c-kit.	2-methyl-4-isothiazolin-3-one	158-160	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	113-118
7524330-3	1994	Since the c-kit receptor tyrosine kinase plays an important role in the development of mast cells, and since the c-kit expression by cultured mast cells from mi/mi mice is deficient in both mRNA and protein levels, the mast cell deficiency of mi/mi mice has been attributed at least in part to the deficient expression of c-kit.	2-methyl-4-isothiazolin-3-one	158-160	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	113-118
7524330-3	1994	Since the c-kit receptor tyrosine kinase plays an important role in the development of mast cells, and since the c-kit expression by cultured mast cells from mi/mi mice is deficient in both mRNA and protein levels, the mast cell deficiency of mi/mi mice has been attributed at least in part to the deficient expression of c-kit.	2-methyl-4-isothiazolin-3-one	161-163	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	113-118
7524330-3	1994	Since the c-kit receptor tyrosine kinase plays an important role in the development of mast cells, and since the c-kit expression by cultured mast cells from mi/mi mice is deficient in both mRNA and protein levels, the mast cell deficiency of mi/mi mice has been attributed at least in part to the deficient expression of c-kit.	2-methyl-4-isothiazolin-3-one	161-163	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	113-118
7524330-3	1994	Since the c-kit receptor tyrosine kinase plays an important role in the development of mast cells, and since the c-kit expression by cultured mast cells from mi/mi mice is deficient in both mRNA and protein levels, the mast cell deficiency of mi/mi mice has been attributed at least in part to the deficient expression of c-kit.	2-methyl-4-isothiazolin-3-one	161-163	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	113-118
7524330-3	1994	Since the c-kit receptor tyrosine kinase plays an important role in the development of mast cells, and since the c-kit expression by cultured mast cells from mi/mi mice is deficient in both mRNA and protein levels, the mast cell deficiency of mi/mi mice has been attributed at least in part to the deficient expression of c-kit.	2-methyl-4-isothiazolin-3-one	161-163	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	113-118
7524330-3	1994	Since the c-kit receptor tyrosine kinase plays an important role in the development of mast cells, and since the c-kit expression by cultured mast cells from mi/mi mice is deficient in both mRNA and protein levels, the mast cell deficiency of mi/mi mice has been attributed at least in part to the deficient expression of c-kit.	2-methyl-4-isothiazolin-3-one	161-163	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	113-118
7524330-3	1994	Since the c-kit receptor tyrosine kinase plays an important role in the development of mast cells, and since the c-kit expression by cultured mast cells from mi/mi mice is deficient in both mRNA and protein levels, the mast cell deficiency of mi/mi mice has been attributed at least in part to the deficient expression of c-kit.	2-methyl-4-isothiazolin-3-one	161-163	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	113-118
7524330-4	1994	However, it remained to be examined whether the c-kit expression was also deficient in tissues of mi/mi mice.	2-methyl-4-isothiazolin-3-one	98-100	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	48-53
7524330-5	1994	In the present study, we examined the c-kit expression by mi/mi skin mast cells using in situ hybridization and immunohistochemistry.	2-methyl-4-isothiazolin-3-one	28-30	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	38-43
7524330-6	1994	Moreover, we examined the c-kit expression by various cells other than mast cells in tissues of mi/mi mice.	2-methyl-4-isothiazolin-3-one	16-18	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	26-31
7524330-6	1994	Moreover, we examined the c-kit expression by various cells other than mast cells in tissues of mi/mi mice.	2-methyl-4-isothiazolin-3-one	96-98	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	26-31
7524330-7	1994	We found that the c-kit expression was deficient in mast cells but not in erythroid precursors, testicular germ cells, and neurons of mi/mi mice.	2-methyl-4-isothiazolin-3-one	137-139	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	18-23
7958544-3	1994	After MI, plasma insulin increased earlier to a peak (60 vs 90 min) which was greater than after HI (294 +/- 24 vs 255 +/- 24 pmol/l), and plasma glucose decreased earlier to a 3 mmol/l plateau (60 vs 120 min) (p < 0.05).	2-methyl-4-isothiazolin-3-one	6-8	insulin	Homo sapiens	17-24
7920028-5	1994	The expression levels of PKC delta in CMC derived from c-kit-deficient mutants, W/W, Wv/Wv, and mi/mi, were lower than that of +/+ mice.	2-methyl-4-isothiazolin-3-one	96-98	protein kinase C, delta	Mus musculus	25-34
7920028-5	1994	The expression levels of PKC delta in CMC derived from c-kit-deficient mutants, W/W, Wv/Wv, and mi/mi, were lower than that of +/+ mice.	2-methyl-4-isothiazolin-3-one	99-101	protein kinase C, delta	Mus musculus	25-34
7517699-3	1994	Since c-kit receptor tyrosine kinase is the gene product of the W locus and mi mutation has been suggested to affect the transduction of signals from the c-kit and c-fms receptors, we here examined the effect of mi mutation on fertility.	2-methyl-4-isothiazolin-3-one	76-78	colony stimulating factor 1 receptor	Mus musculus	164-169
7517699-7	1994	Decidual cells were present and expressed c-kit protein normally in the placenta of mi/mi mice.	2-methyl-4-isothiazolin-3-one	84-86	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	42-47
7517699-7	1994	Decidual cells were present and expressed c-kit protein normally in the placenta of mi/mi mice.	2-methyl-4-isothiazolin-3-one	87-89	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	42-47
8479820-0	1993	Combination macrophage-colony stimulating factor and interferon-gamma administration ameliorates the osteopetrotic condition in microphthalmic (mi/mi) mice.	2-methyl-4-isothiazolin-3-one	128-130	colony stimulating factor 1	Homo sapiens	12-48
8400241-12	1993	In contrast, when cultured in the presence of galactose alone, or in the absence of both galactose and N-acetylgalactosamine, Mi.I mutant glycophorin A lacking both N-linked and O-linked oligosaccharides was not expressed at the cell surface.	2-methyl-4-isothiazolin-3-one	126-128	glycophorin A (MNS blood group)	Homo sapiens	138-151
8479820-0	1993	Combination macrophage-colony stimulating factor and interferon-gamma administration ameliorates the osteopetrotic condition in microphthalmic (mi/mi) mice.	2-methyl-4-isothiazolin-3-one	128-130	interferon gamma	Mus musculus	53-69
1381628-0	1992	Low c-kit expression of cultured mast cells of mi/mi genotype may be involved in their defective responses to fibroblasts that express the ligand for c-kit.	2-methyl-4-isothiazolin-3-one	47-49	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	4-9
7522503-0	1993	PKC gamma gene expression is delayed in postnatal central nervous system of mi/mi mice.	2-methyl-4-isothiazolin-3-one	76-78	protein kinase C, gamma	Mus musculus	0-9
7522503-0	1993	PKC gamma gene expression is delayed in postnatal central nervous system of mi/mi mice.	2-methyl-4-isothiazolin-3-one	79-81	protein kinase C, gamma	Mus musculus	0-9
1381628-0	1992	Low c-kit expression of cultured mast cells of mi/mi genotype may be involved in their defective responses to fibroblasts that express the ligand for c-kit.	2-methyl-4-isothiazolin-3-one	47-49	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	150-155
1381628-0	1992	Low c-kit expression of cultured mast cells of mi/mi genotype may be involved in their defective responses to fibroblasts that express the ligand for c-kit.	2-methyl-4-isothiazolin-3-one	50-52	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	4-9
1381628-0	1992	Low c-kit expression of cultured mast cells of mi/mi genotype may be involved in their defective responses to fibroblasts that express the ligand for c-kit.	2-methyl-4-isothiazolin-3-one	50-52	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	150-155
1381628-2	1992	In an effort to further understand the mechanisms behind why mi/mi mouse-derived cultured mast cells (mi/mi-CMC) responded to interleukin-3 (IL-3), but not to the proliferative stimuli presented by fibroblasts, mi/mi-CMC and congenic normal (+/+) mouse-derived CMC (+/+-CMC), both of which expressed the phenotypic characteristics of immature mast cells, were cocultured with Swiss albino/3T3 fibroblasts in a medium containing IL-3.	2-methyl-4-isothiazolin-3-one	61-63	interleukin 3	Mus musculus	126-139
1381628-2	1992	In an effort to further understand the mechanisms behind why mi/mi mouse-derived cultured mast cells (mi/mi-CMC) responded to interleukin-3 (IL-3), but not to the proliferative stimuli presented by fibroblasts, mi/mi-CMC and congenic normal (+/+) mouse-derived CMC (+/+-CMC), both of which expressed the phenotypic characteristics of immature mast cells, were cocultured with Swiss albino/3T3 fibroblasts in a medium containing IL-3.	2-methyl-4-isothiazolin-3-one	61-63	interleukin 3	Mus musculus	141-145
1381628-2	1992	In an effort to further understand the mechanisms behind why mi/mi mouse-derived cultured mast cells (mi/mi-CMC) responded to interleukin-3 (IL-3), but not to the proliferative stimuli presented by fibroblasts, mi/mi-CMC and congenic normal (+/+) mouse-derived CMC (+/+-CMC), both of which expressed the phenotypic characteristics of immature mast cells, were cocultured with Swiss albino/3T3 fibroblasts in a medium containing IL-3.	2-methyl-4-isothiazolin-3-one	64-66	interleukin 3	Mus musculus	126-139
1381628-2	1992	In an effort to further understand the mechanisms behind why mi/mi mouse-derived cultured mast cells (mi/mi-CMC) responded to interleukin-3 (IL-3), but not to the proliferative stimuli presented by fibroblasts, mi/mi-CMC and congenic normal (+/+) mouse-derived CMC (+/+-CMC), both of which expressed the phenotypic characteristics of immature mast cells, were cocultured with Swiss albino/3T3 fibroblasts in a medium containing IL-3.	2-methyl-4-isothiazolin-3-one	64-66	interleukin 3	Mus musculus	141-145
16668360-2	1991	Aps-1 is closely linked to Mi, a gene conferring resistance against nematodes.	2-methyl-4-isothiazolin-3-one	27-29	acid phosphatase 1	Solanum lycopersicum	0-5
24213330-4	1991	Based on the analysis of more than 1,000 F2 plants from four crosses, we were able to pinpoint the Mi gene to the interval between two of these markers - GP79 and Aps-1.	2-methyl-4-isothiazolin-3-one	99-101	acid phosphatase 1	Solanum lycopersicum	163-168
16668360-3	1991	Thus, a clone of Aps-1 would provide access to the region of the genome containing Mi.	2-methyl-4-isothiazolin-3-one	83-85	acid phosphatase 1	Solanum lycopersicum	17-22
1935038-1	1991	In an attempt to define the optimal test concentration for isothiazolinones, 200 and 100 ppm of 5-chloro-2-methyl-4-isothiazolin-3-one/2-methyl-4- isothiazolin-3-one (MCI/MI) in aq.	2-methyl-4-isothiazolin-3-one	135-165	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	167-170
2211836-8	1990	Thus, PTH-driven differentiation of osteoclasts is arrested in calvarial cell cultures from mi/mi mice, but mi/mi preosteoclasts retain the ability to express certain osteoclast markers in response to bone derived signals.	2-methyl-4-isothiazolin-3-one	92-94	parathyroid hormone	Mus musculus	6-9
1722368-7	1991	Serological and immunochemical studies with human and monoclonal antibodies to various determinants on glycophorin A (GPA) suggest that Mi.IX is associated with an aberrant GPA molecule that lacks the trypsin cleavage site at amino-acid residue 39, retains the chymotrypsin cleavage site at residue 34 and has an apparent Mr of about 1,000 less than normal GPA.	2-methyl-4-isothiazolin-3-one	136-138	glycophorin A (MNS blood group)	Homo sapiens	103-116
1722368-7	1991	Serological and immunochemical studies with human and monoclonal antibodies to various determinants on glycophorin A (GPA) suggest that Mi.IX is associated with an aberrant GPA molecule that lacks the trypsin cleavage site at amino-acid residue 39, retains the chymotrypsin cleavage site at residue 34 and has an apparent Mr of about 1,000 less than normal GPA.	2-methyl-4-isothiazolin-3-one	136-138	glycophorin A (MNS blood group)	Homo sapiens	118-121
1722368-7	1991	Serological and immunochemical studies with human and monoclonal antibodies to various determinants on glycophorin A (GPA) suggest that Mi.IX is associated with an aberrant GPA molecule that lacks the trypsin cleavage site at amino-acid residue 39, retains the chymotrypsin cleavage site at residue 34 and has an apparent Mr of about 1,000 less than normal GPA.	2-methyl-4-isothiazolin-3-one	136-138	glycophorin A (MNS blood group)	Homo sapiens	173-176
1722368-7	1991	Serological and immunochemical studies with human and monoclonal antibodies to various determinants on glycophorin A (GPA) suggest that Mi.IX is associated with an aberrant GPA molecule that lacks the trypsin cleavage site at amino-acid residue 39, retains the chymotrypsin cleavage site at residue 34 and has an apparent Mr of about 1,000 less than normal GPA.	2-methyl-4-isothiazolin-3-one	136-138	glycophorin A (MNS blood group)	Homo sapiens	173-176
2211836-8	1990	Thus, PTH-driven differentiation of osteoclasts is arrested in calvarial cell cultures from mi/mi mice, but mi/mi preosteoclasts retain the ability to express certain osteoclast markers in response to bone derived signals.	2-methyl-4-isothiazolin-3-one	95-97	parathyroid hormone	Mus musculus	6-9
2211836-8	1990	Thus, PTH-driven differentiation of osteoclasts is arrested in calvarial cell cultures from mi/mi mice, but mi/mi preosteoclasts retain the ability to express certain osteoclast markers in response to bone derived signals.	2-methyl-4-isothiazolin-3-one	95-97	parathyroid hormone	Mus musculus	6-9
2211836-8	1990	Thus, PTH-driven differentiation of osteoclasts is arrested in calvarial cell cultures from mi/mi mice, but mi/mi preosteoclasts retain the ability to express certain osteoclast markers in response to bone derived signals.	2-methyl-4-isothiazolin-3-one	95-97	parathyroid hormone	Mus musculus	6-9
2547466-5	1989	Collagenase activity of media of cells from normal or mi/mi mice treated with PTH or LPS yielded identical elution patterns upon chromatography on lysine-Sepharose.	2-methyl-4-isothiazolin-3-one	54-56	parathyroid hormone	Mus musculus	78-81
2792104-4	1989	By Western blot analysis with rabbit anti-GPA antibodies specific for discrete domains of GPA, it was found that the Mi.	2-methyl-4-isothiazolin-3-one	117-119	glycophorin A (MNS blood group)	Homo sapiens	42-45
2792104-4	1989	By Western blot analysis with rabbit anti-GPA antibodies specific for discrete domains of GPA, it was found that the Mi.	2-methyl-4-isothiazolin-3-one	117-119	glycophorin A (MNS blood group)	Homo sapiens	90-93
2792104-16	1989	In addition, the finding that part of the signal peptide and the 5"-untranslated region are derived from GPB suggests that the genetic background of the Mi.	2-methyl-4-isothiazolin-3-one	153-155	glycophorin B (MNS blood group)	Homo sapiens	105-108
2547466-0	1989	Stimulation of collagenolytic enzyme release from cultured bone cells of normal and osteopetrotic (mi/mi) mice by parathyroid hormone and lipopolysaccharide.	2-methyl-4-isothiazolin-3-one	99-101	parathyroid hormone	Mus musculus	114-133
2547466-0	1989	Stimulation of collagenolytic enzyme release from cultured bone cells of normal and osteopetrotic (mi/mi) mice by parathyroid hormone and lipopolysaccharide.	2-methyl-4-isothiazolin-3-one	102-104	parathyroid hormone	Mus musculus	114-133
2547466-2	1989	Treatment of cells from either normal or mi/mi mice with parathyroid hormone (PTH) or lipopolysaccharide (LPS) resulted in the appearance of latent collagenolytic enzyme activity in the medium.	2-methyl-4-isothiazolin-3-one	41-43	parathyroid hormone	Mus musculus	57-76
2547466-2	1989	Treatment of cells from either normal or mi/mi mice with parathyroid hormone (PTH) or lipopolysaccharide (LPS) resulted in the appearance of latent collagenolytic enzyme activity in the medium.	2-methyl-4-isothiazolin-3-one	41-43	parathyroid hormone	Mus musculus	78-81
2547466-2	1989	Treatment of cells from either normal or mi/mi mice with parathyroid hormone (PTH) or lipopolysaccharide (LPS) resulted in the appearance of latent collagenolytic enzyme activity in the medium.	2-methyl-4-isothiazolin-3-one	44-46	parathyroid hormone	Mus musculus	57-76
2547466-2	1989	Treatment of cells from either normal or mi/mi mice with parathyroid hormone (PTH) or lipopolysaccharide (LPS) resulted in the appearance of latent collagenolytic enzyme activity in the medium.	2-methyl-4-isothiazolin-3-one	44-46	parathyroid hormone	Mus musculus	78-81
2547466-5	1989	Collagenase activity of media of cells from normal or mi/mi mice treated with PTH or LPS yielded identical elution patterns upon chromatography on lysine-Sepharose.	2-methyl-4-isothiazolin-3-one	57-59	parathyroid hormone	Mus musculus	78-81
2439339-3	1987	The Mi-VII-specific glycophorin A was shown to exhibit an arginine----threonine and a tyrosine----serine exchange at the positions 49 and 52 respectively.	2-methyl-4-isothiazolin-3-one	4-6	glycophorin A (MNS blood group)	Homo sapiens	20-33
2439339-5	1987	Inhibition assays demonstrated that one of the Mi-VII-specific antigen determinants (Anek) is located within the residues 40-61 of glycophorin A and comprises sialic acid residue(s) attached to O-glycosidically linked oligosaccharide(s).	2-methyl-4-isothiazolin-3-one	47-49	glycophorin A (MNS blood group)	Homo sapiens	131-144
6571820-3	1983	PTH, 1,25-(OH)2D3, and PGE2 stimulated the release of 3H-labeled material into the culture medium from both normal and mi/mi calvaria.	2-methyl-4-isothiazolin-3-one	119-121	parathyroid hormone	Mus musculus	0-3
3926280-1	1985	The effect of parathormone (PTH), lipopolysaccharide (LPS), or interleukin-1 (IL-1) on calcium release and collagen degradation in bone was examined in vitro using labeled neonatal calvaria of normal mice and also of osteopetrotic microphthalmic (mi/mi) mice that have defective osteoclasts.	2-methyl-4-isothiazolin-3-one	143-145	interleukin 1 complex	Mus musculus	63-82
3926280-3	1985	PTH stimulated the degradation of both noncalcified and calcified collagen in normal bone as well as the degradation of noncalcified collagen in mi/mi bone.	2-methyl-4-isothiazolin-3-one	145-147	parathyroid hormone	Mus musculus	0-3
3926280-3	1985	PTH stimulated the degradation of both noncalcified and calcified collagen in normal bone as well as the degradation of noncalcified collagen in mi/mi bone.	2-methyl-4-isothiazolin-3-one	148-150	parathyroid hormone	Mus musculus	0-3
3926280-5	1985	One-half maximal stimulation of noncalcified collagen degradation in normal or mi/mi bone was achieved by about 3 nM PTH compared with about 1 nM PTH for that of calcium release from normal bone.	2-methyl-4-isothiazolin-3-one	79-81	parathyroid hormone	Mus musculus	117-120
3926280-5	1985	One-half maximal stimulation of noncalcified collagen degradation in normal or mi/mi bone was achieved by about 3 nM PTH compared with about 1 nM PTH for that of calcium release from normal bone.	2-methyl-4-isothiazolin-3-one	79-81	parathyroid hormone	Mus musculus	146-149
3938292-2	1985	Monospecific rabbit polyclonal antibodies against purified rat carbonic anhydrase I or II detected both isozymes in hemolysates of both normal and mi/mi mice.	2-methyl-4-isothiazolin-3-one	147-149	carbonic anhydrase 1	Rattus norvegicus	63-83
3938292-2	1985	Monospecific rabbit polyclonal antibodies against purified rat carbonic anhydrase I or II detected both isozymes in hemolysates of both normal and mi/mi mice.	2-methyl-4-isothiazolin-3-one	150-152	carbonic anhydrase 1	Rattus norvegicus	63-83
3938292-5	1985	CA II dominates the observed activity of hemolysates of normal and mi/mi mice.	2-methyl-4-isothiazolin-3-one	8-10	carbonic anhydrase 2	Mus musculus	0-5
3938292-5	1985	CA II dominates the observed activity of hemolysates of normal and mi/mi mice.	2-methyl-4-isothiazolin-3-one	67-69	carbonic anhydrase 2	Mus musculus	0-5
3938292-6	1985	Immunohistochemical studies showed that CA II was present in osteoclasts of tibial and calvarial bones of both normal and mi/mi mice.	2-methyl-4-isothiazolin-3-one	14-16	carbonic anhydrase 2	Mus musculus	40-45
3938292-6	1985	Immunohistochemical studies showed that CA II was present in osteoclasts of tibial and calvarial bones of both normal and mi/mi mice.	2-methyl-4-isothiazolin-3-one	122-124	carbonic anhydrase 2	Mus musculus	40-45
6571820-3	1983	PTH, 1,25-(OH)2D3, and PGE2 stimulated the release of 3H-labeled material into the culture medium from both normal and mi/mi calvaria.	2-methyl-4-isothiazolin-3-one	122-124	parathyroid hormone	Mus musculus	0-3
6571820-5	1983	PTH also stimulated the release of 3H-labeled materials from normal calvaria labeled in vivo 112 h before the mice were killed, but had little or no effect on 3H release from the mi/mi bone, indicating that only noncalcified collagen is susceptible to hormone-stimulated degradation in osteopetrotic bone.	2-methyl-4-isothiazolin-3-one	110-112	parathyroid hormone	Mus musculus	0-3
6172902-2	1981	The cells of the donor represent a new Mi class, VIII, by sharing determinants found on cells of MiIV, VI and VII.	2-methyl-4-isothiazolin-3-one	39-41	cytochrome c oxidase subunit 8A	Homo sapiens	49-53
32162171-6	2021	In the MI group, the expression levels of circMACF1 and EMP1 were decreased with the increasing expression level of miR-500b-5p.	2-methyl-4-isothiazolin-3-one	7-9	epithelial membrane protein 1	Homo sapiens	56-60
230820-10	1979	Our results suggest that the new sialoglycorportein present in Mi.V erythrocytes is a hybrid of the normal MN sialoglycoprotein and an s-active sialoglycoprotein that has properties similar to the s-active sialoglycoprotein found in Mi.III erythrocytes.	2-methyl-4-isothiazolin-3-one	63-65	glycophorin A (MNS blood group)	Homo sapiens	107-127
32162171-6	2021	In the MI group, the expression levels of circMACF1 and EMP1 were decreased with the increasing expression level of miR-500b-5p.	2-methyl-4-isothiazolin-3-one	7-9	microRNA 500b	Homo sapiens	116-124
32139713-0	2020	Effects of chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) on Th2/Th17-related immune modulation in an atopic dermatitis mouse model.	2-methyl-4-isothiazolin-3-one	17-38	heart and neural crest derivatives expressed 2	Mus musculus	75-78
32179044-7	2020	While, upregulation of autophagy by cardiac-specific beclin1 overexpression partially ameliorated cardiac dysfunction after MI.	2-methyl-4-isothiazolin-3-one	124-126	beclin 1	Homo sapiens	53-60
32190895-12	2020	Finally, we further elucidated the important regulatory role of the mi R-27a-APAF1 axis in OC through in vivo experiments.	2-methyl-4-isothiazolin-3-one	68-70	apoptotic peptidase activating factor 1	Homo sapiens	77-82
32139713-0	2020	Effects of chloromethylisothiazolinone/methylisothiazolinone (CMIT/MIT) on Th2/Th17-related immune modulation in an atopic dermatitis mouse model.	2-methyl-4-isothiazolin-3-one	63-66	heart and neural crest derivatives expressed 2	Mus musculus	75-78
31164636-10	2019	Small molecule MI-743 with 5-cyano-6-phenylpyrimidine structure may serve as a novel lead compound targeting the overexpressed MTH1 for gastric cancer treatment.	2-methyl-4-isothiazolin-3-one	15-17	nudix hydrolase 1	Homo sapiens	127-131
31638238-8	2019	Furthermore, mi-233 should have been written as miR-223 at the following places in the text: p. 4051, right-hand column (RHC), line 10 ("Furthermore, the miR-223-regulated...); p. 4054, Results section, left-hand column (LHC), third subheading ("miR-223 negatively regulates the expression of NLRP3.	2-methyl-4-isothiazolin-3-one	13-15	microRNA 223	Rattus norvegicus	48-55
31638238-8	2019	Furthermore, mi-233 should have been written as miR-223 at the following places in the text: p. 4051, right-hand column (RHC), line 10 ("Furthermore, the miR-223-regulated...); p. 4054, Results section, left-hand column (LHC), third subheading ("miR-223 negatively regulates the expression of NLRP3.	2-methyl-4-isothiazolin-3-one	13-15	microRNA 223	Rattus norvegicus	154-161
31638238-8	2019	Furthermore, mi-233 should have been written as miR-223 at the following places in the text: p. 4051, right-hand column (RHC), line 10 ("Furthermore, the miR-223-regulated...); p. 4054, Results section, left-hand column (LHC), third subheading ("miR-223 negatively regulates the expression of NLRP3.	2-methyl-4-isothiazolin-3-one	13-15	microRNA 223	Rattus norvegicus	154-161
31638238-8	2019	Furthermore, mi-233 should have been written as miR-223 at the following places in the text: p. 4051, right-hand column (RHC), line 10 ("Furthermore, the miR-223-regulated...); p. 4054, Results section, left-hand column (LHC), third subheading ("miR-223 negatively regulates the expression of NLRP3.	2-methyl-4-isothiazolin-3-one	13-15	NLR family, pyrin domain containing 3	Rattus norvegicus	293-298
31468674-4	2019	As massive cardiomyocytes die after MI, we hypothesize that AnxA5 can be used as an anchor to carry SDF-1 to the ischaemic myocardium.	2-methyl-4-isothiazolin-3-one	36-38	annexin A5	Mus musculus	60-65
31343368-7	2019	Over- expression of Mi-34a or knockdown of HNF4alpha in SH-SY5Y cells could lead to a decreased of cell proliferation, migration, invasion and the expression of MMP-2 and MMP-14 (p < .05).	2-methyl-4-isothiazolin-3-one	20-22	matrix metallopeptidase 2	Homo sapiens	161-166
31343368-7	2019	Over- expression of Mi-34a or knockdown of HNF4alpha in SH-SY5Y cells could lead to a decreased of cell proliferation, migration, invasion and the expression of MMP-2 and MMP-14 (p < .05).	2-methyl-4-isothiazolin-3-one	20-22	matrix metallopeptidase 14	Homo sapiens	171-177
31462157-10	2019	CONCLUSIONS: Transplantation of hUCB-derived CD45- Lin- nonhematopoietic cellular subfraction after a reperfused MI in nonimmunosuppressed rats ameliorates LV dysfunction and improves remodeling via favorable paracrine modulation of molecular pathways.	2-methyl-4-isothiazolin-3-one	113-115	protein tyrosine phosphatase, receptor type, C	Rattus norvegicus	45-49
31276463-5	2019	The novel technique consists of the MI-OCT-guided puncture and drainage of intrastromal fluid pockets combined with anterior chamber sulfur hexafluoride-fill and pre-descemetic sutures using a commercially available MI-OCT (iOCT; Haag Streit Surgical, Wedel, Germany).	2-methyl-4-isothiazolin-3-one	36-38	plexin A2	Homo sapiens	39-42
30922724-8	2019	The MI-material based analytical platform was sensitive for the determination of TCs in milk samples with LOD values in the range of 2.23-26.84 ng mL-1 and recoveries ranged from 86.2% to 105.7%.	2-methyl-4-isothiazolin-3-one	4-6	L1 cell adhesion molecule	Mus musculus	147-151
31191799-14	2019	Taken together, miR-155 is upregulated in the MI heart and NRVMs in response to H2O2 stress, and downregulating of miR-155 protects cardiomyocytes against apoptosis.	2-methyl-4-isothiazolin-3-one	46-48	microRNA 155	Mus musculus	16-23
29982930-2	2018	Here we aimed to testify the therapeutic effects of sustained release of basic fibroblast growth factor (bFGF) using gelatin hydrogel (GH) in a rat chronic MI model and to elucidate the therapeutic mechanism including the alteration of extracellular matrix component.	2-methyl-4-isothiazolin-3-one	156-158	fibroblast growth factor 2	Rattus norvegicus	73-103
30516302-7	2019	Compared with the SO group, Cx43, SOD, and Bcl-2 were decreased, MDA, Bax, caspase-3, TNF-alpha, IL-6, and HMGB1 were increased in the MI group, and all the alterations were significantly restrained in the LOMD+AMI group.	2-methyl-4-isothiazolin-3-one	135-137	gap junction protein alpha 1	Canis lupus familiaris	28-32
30516302-7	2019	Compared with the SO group, Cx43, SOD, and Bcl-2 were decreased, MDA, Bax, caspase-3, TNF-alpha, IL-6, and HMGB1 were increased in the MI group, and all the alterations were significantly restrained in the LOMD+AMI group.	2-methyl-4-isothiazolin-3-one	135-137	BCL2 apoptosis regulator	Canis lupus familiaris	43-48
30516302-7	2019	Compared with the SO group, Cx43, SOD, and Bcl-2 were decreased, MDA, Bax, caspase-3, TNF-alpha, IL-6, and HMGB1 were increased in the MI group, and all the alterations were significantly restrained in the LOMD+AMI group.	2-methyl-4-isothiazolin-3-one	135-137	BCL2 associated X, apoptosis regulator	Canis lupus familiaris	70-73
30516302-7	2019	Compared with the SO group, Cx43, SOD, and Bcl-2 were decreased, MDA, Bax, caspase-3, TNF-alpha, IL-6, and HMGB1 were increased in the MI group, and all the alterations were significantly restrained in the LOMD+AMI group.	2-methyl-4-isothiazolin-3-one	135-137	caspase 3	Canis lupus familiaris	75-84
30516302-7	2019	Compared with the SO group, Cx43, SOD, and Bcl-2 were decreased, MDA, Bax, caspase-3, TNF-alpha, IL-6, and HMGB1 were increased in the MI group, and all the alterations were significantly restrained in the LOMD+AMI group.	2-methyl-4-isothiazolin-3-one	135-137	tumor necrosis factor	Canis lupus familiaris	86-95
30516302-7	2019	Compared with the SO group, Cx43, SOD, and Bcl-2 were decreased, MDA, Bax, caspase-3, TNF-alpha, IL-6, and HMGB1 were increased in the MI group, and all the alterations were significantly restrained in the LOMD+AMI group.	2-methyl-4-isothiazolin-3-one	135-137	interleukin 6	Canis lupus familiaris	97-101
30516302-7	2019	Compared with the SO group, Cx43, SOD, and Bcl-2 were decreased, MDA, Bax, caspase-3, TNF-alpha, IL-6, and HMGB1 were increased in the MI group, and all the alterations were significantly restrained in the LOMD+AMI group.	2-methyl-4-isothiazolin-3-one	135-137	high mobility group box 1	Canis lupus familiaris	107-112
30378501-4	2019	Granulocyte Colony-Stimulating Factor (G-CSF), is a hematopoietic cytokine that promotes proliferation and differentiation of neutrophils and is involved in cardiac repair after MI.	2-methyl-4-isothiazolin-3-one	178-180	colony stimulating factor 3	Homo sapiens	0-37
30378501-4	2019	Granulocyte Colony-Stimulating Factor (G-CSF), is a hematopoietic cytokine that promotes proliferation and differentiation of neutrophils and is involved in cardiac repair after MI.	2-methyl-4-isothiazolin-3-one	178-180	colony stimulating factor 3	Homo sapiens	39-44
30318714-3	2019	We present a case of allergic contact dermatitis secondary to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in school glue used to make slime; mass spectroscopy confirmed MCI/MI in the patient"s glue.	2-methyl-4-isothiazolin-3-one	90-111	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	113-116
30318714-3	2019	We present a case of allergic contact dermatitis secondary to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in school glue used to make slime; mass spectroscopy confirmed MCI/MI in the patient"s glue.	2-methyl-4-isothiazolin-3-one	90-111	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	184-187
29982930-2	2018	Here we aimed to testify the therapeutic effects of sustained release of basic fibroblast growth factor (bFGF) using gelatin hydrogel (GH) in a rat chronic MI model and to elucidate the therapeutic mechanism including the alteration of extracellular matrix component.	2-methyl-4-isothiazolin-3-one	156-158	fibroblast growth factor 2	Rattus norvegicus	105-109
29990866-7	2018	RESULTS: MALAT1 and Pten were highly expressed, while miR-320 was suppressed in MI group.	2-methyl-4-isothiazolin-3-one	80-82	microRNA 320	Mus musculus	54-61
29692277-5	2018	To evaluate the silencing efficacy of Mi-glp-1, transgenic Arabidopsis plants carrying double-stranded RNA constructs of glp-1 were generated, and infection of these plants with M. incognita resulted in a 47-50% reduction in the numbers of galls, females and egg masses.	2-methyl-4-isothiazolin-3-one	38-40	germin-like protein 1	Arabidopsis thaliana	41-46
29393340-7	2018	In comparison to TP53 wt human neuroblastoma cells, Trp53 wt murine control and TH-MYCN cell lines were significantly less sensitive to growth inhibition mediated by MI-63 and RG7388.	2-methyl-4-isothiazolin-3-one	166-168	tumor protein p53	Homo sapiens	52-57
30603005-7	2018	Results: Data obtained showed that serum CKMB, LDH1, AST, Troponin T and ADMA levels were significant elevated in MI with or without Thalassemia compared with control groups.	2-methyl-4-isothiazolin-3-one	114-116	solute carrier family 17 member 5	Homo sapiens	53-56
30300044-10	2018	Concomitantly, it lowered the increased protein levels of angiotensin-converting enzyme (ACE), p22phox and cleaved caspase-3 and prevented the aorta histological and ultrustructural abnormalities induced by MI.	2-methyl-4-isothiazolin-3-one	207-209	angiotensin I converting enzyme	Rattus norvegicus	58-87
29393340-7	2018	In comparison to TP53 wt human neuroblastoma cells, Trp53 wt murine control and TH-MYCN cell lines were significantly less sensitive to growth inhibition mediated by MI-63 and RG7388.	2-methyl-4-isothiazolin-3-one	166-168	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	83-87
29393340-10	2018	The identified species-dependent selectivity of MI-63 and RG7388 should be considered when interpreting in vivo toxicity studies of MDM2 inhibitors.	2-methyl-4-isothiazolin-3-one	48-50	transformed mouse 3T3 cell double minute 2	Mus musculus	132-136
28771550-6	2017	Patients with MI and patients with adverse outcome had higher GDF-15 levels compared with non-MI patients (967.1pg/mL vs. 692.2 pg/L, p<0.001) and with event-free patients (1660 pg/mL vs. 756.6 pg/L, p<0.001).	2-methyl-4-isothiazolin-3-one	14-16	growth differentiation factor 15	Homo sapiens	62-68
28765889-10	2017	The downregulation of mi-143 promoted cell proliferation by regulating PKCepsilon in the HCC cells.	2-methyl-4-isothiazolin-3-one	22-24	protein kinase C epsilon	Homo sapiens	71-81
28839212-8	2017	Through the overexpression and inhibition of mi-34c, we demonstrated that miR-34c inhibits PSCs proliferation and promotes PSCs differentiation.	2-methyl-4-isothiazolin-3-one	45-47	microRNA 34c	Homo sapiens	74-81
28771550-8	2017	Increased GDF-15 levels on admission were associated with a hazard ratio of 2.1 for death or MI (95%CI: 1.67-2.65, p<0.001) in a model adjusted for age and sex and of 1.57 (1.13-2.19, p = 0.008) adjusted for the GRACE score variables.	2-methyl-4-isothiazolin-3-one	93-95	growth differentiation factor 15	Homo sapiens	10-16
28771550-10	2017	CONCLUSION: GDF-15 is an independent predictor of future cardiovascular events in patients presenting with suspected MI.	2-methyl-4-isothiazolin-3-one	117-119	growth differentiation factor 15	Homo sapiens	12-18
28732009-10	2017	The densities of GAP43 and TH-positive nerve fibers in the infarcted border zone in the MI-ablation group were lower than those in the MI group (p<0.05).	2-methyl-4-isothiazolin-3-one	88-90	growth associated protein 43	Canis lupus familiaris	17-22
27552568-9	2016	There is an insignificant difference between the means of serum anxA5 levels of acute MI (35.6+-7.2ng/ml) and chronic MI (32.4+-8.9ng/ml), but significantly higher than the cutoff level of the healthy subjects (5ng/ml).	2-methyl-4-isothiazolin-3-one	86-88	annexin A5	Homo sapiens	64-69
28338542-1	2017	BACKGROUND: The preservatives methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and MI are well-known contact sensitizers.	2-methyl-4-isothiazolin-3-one	58-79	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	81-87
28300444-1	2017	BACKGROUND: Contact allergy to methylisothiazolinone (MI) or to the combination of methylchloroisothiazolinone and MI (MCI/MI) is an important and increasing cause of allergic contact dermatitis, with prevalence rates higher than 10% in some centers.	2-methyl-4-isothiazolin-3-one	31-52	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	119-125
27550999-3	2017	Here, we evaluated the antitumor effect of a novel small-molecule inhibitor of the MDM2-p53 interaction (MI-773) combined with cisplatin in patient-derived xenograft (PDX) ACC tumors.Experimental Design: Therapeutic strategies with MI-773 and/or cisplatin were evaluated in SCID mice harboring PDX ACC tumors (UM-PDX-HACC-5) and in low passage primary human ACC cells (UM-HACC-2A, -2B, -5, -6) in vitro The effect of therapy on the fraction of cancer stem cells (CSC) was determined by flow cytometry for ALDH activity and CD44 expression.Results: Combined therapy with MI-773 with cisplatin caused p53 activation, induction of apoptosis, and regression of ACC PDX tumors.	2-methyl-4-isothiazolin-3-one	105-107	MDM2 proto-oncogene	Homo sapiens	83-87
27550999-3	2017	Here, we evaluated the antitumor effect of a novel small-molecule inhibitor of the MDM2-p53 interaction (MI-773) combined with cisplatin in patient-derived xenograft (PDX) ACC tumors.Experimental Design: Therapeutic strategies with MI-773 and/or cisplatin were evaluated in SCID mice harboring PDX ACC tumors (UM-PDX-HACC-5) and in low passage primary human ACC cells (UM-HACC-2A, -2B, -5, -6) in vitro The effect of therapy on the fraction of cancer stem cells (CSC) was determined by flow cytometry for ALDH activity and CD44 expression.Results: Combined therapy with MI-773 with cisplatin caused p53 activation, induction of apoptosis, and regression of ACC PDX tumors.	2-methyl-4-isothiazolin-3-one	105-107	tumor protein p53	Homo sapiens	88-91
27550999-7	2017	In contrast, 62.5% of mice that received vehicle control presented with palpable tumor recurrences within this time period (P = 0.0097).Conclusions: Collectively, these data demonstrate that therapeutic inhibition of MDM2-p53 interaction by MI-773 decreased the CSC fraction, sensitized ACC xenograft tumors to cisplatin, and eliminated tumor recurrence.	2-methyl-4-isothiazolin-3-one	241-243	transformed mouse 3T3 cell double minute 2	Mus musculus	217-221
27550999-7	2017	In contrast, 62.5% of mice that received vehicle control presented with palpable tumor recurrences within this time period (P = 0.0097).Conclusions: Collectively, these data demonstrate that therapeutic inhibition of MDM2-p53 interaction by MI-773 decreased the CSC fraction, sensitized ACC xenograft tumors to cisplatin, and eliminated tumor recurrence.	2-methyl-4-isothiazolin-3-one	241-243	transformation related protein 53, pseudogene	Mus musculus	222-225
27312540-12	2017	CONCLUSION: In DCIS and DCIS-Mi cases, significant correlations were found between increased FDG uptake and several histological and biological factors for poor prognosis (tumor size, Van Nuys Prognostic Index, and HER2).	2-methyl-4-isothiazolin-3-one	29-31	erb-b2 receptor tyrosine kinase 2	Homo sapiens	215-219
28509716-1	2017	BACKGROUND: The preservative methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is a well-known contact sensitizer.	2-methyl-4-isothiazolin-3-one	57-78	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	80-83
27943171-5	2017	In this review, we present a comprehensive account of the systematic development of and recent progress in diverse spiro-oxindole derivatives active as potent selective inhibitors of p53-MDM2 interaction with special emphasis on spiro-pyrrolidinyl oxindoles (the MI series), their mechanism of action, and structure-activity relationship.	2-methyl-4-isothiazolin-3-one	263-265	tumor protein p53	Homo sapiens	183-186
27943171-5	2017	In this review, we present a comprehensive account of the systematic development of and recent progress in diverse spiro-oxindole derivatives active as potent selective inhibitors of p53-MDM2 interaction with special emphasis on spiro-pyrrolidinyl oxindoles (the MI series), their mechanism of action, and structure-activity relationship.	2-methyl-4-isothiazolin-3-one	263-265	MDM2 proto-oncogene	Homo sapiens	187-191
27145058-7	2016	The associations between contact allergy to MCI/MI and/or MI and FM I and/or FM II, and between formaldehyde and FM I and/or FM II as well as, were statistically significant (p < 0.001).	2-methyl-4-isothiazolin-3-one	48-50	protein tyrosine phosphatase receptor type U	Homo sapiens	65-69
27145058-7	2016	The associations between contact allergy to MCI/MI and/or MI and FM I and/or FM II, and between formaldehyde and FM I and/or FM II as well as, were statistically significant (p < 0.001).	2-methyl-4-isothiazolin-3-one	48-50	protein tyrosine phosphatase receptor type U	Homo sapiens	77-81
27145058-7	2016	The associations between contact allergy to MCI/MI and/or MI and FM I and/or FM II, and between formaldehyde and FM I and/or FM II as well as, were statistically significant (p < 0.001).	2-methyl-4-isothiazolin-3-one	58-60	protein tyrosine phosphatase receptor type U	Homo sapiens	65-69
27085674-5	2016	In contrast, probe 7, derived from the known covalent inhibitor MI-2, labels both wild type and catalytically inactive Cys to Ala mutant Malt1, suggesting that MI-2 inhibits Malt1 by reacting with a nucleophilic residue other than the active site cysteine.	2-methyl-4-isothiazolin-3-one	64-66	MALT1 paracaspase	Homo sapiens	137-142
26654716-16	2016	CONCLUSIONS: miR-16 controls KCNJ2 expression, and valsartan ameliorates Kir2.1 after MI partly depending on the NF-kappaB-miR-16 pathway.	2-methyl-4-isothiazolin-3-one	86-88	potassium inwardly-rectifying channel, subfamily J, member 2	Rattus norvegicus	73-79
27605379-34	2016	The BTG4-CAF1 complex drives the shortening of the poly(A) tails of a large number of transcripts at the MI-MII transition, and this wave of deadenylation is essential for the arrest in metaphase II.	2-methyl-4-isothiazolin-3-one	105-107	BTG anti-proliferation factor 4	Homo sapiens	4-8
27605379-34	2016	The BTG4-CAF1 complex drives the shortening of the poly(A) tails of a large number of transcripts at the MI-MII transition, and this wave of deadenylation is essential for the arrest in metaphase II.	2-methyl-4-isothiazolin-3-one	105-107	chromatin assembly factor 1 subunit A	Homo sapiens	9-13
27085674-5	2016	In contrast, probe 7, derived from the known covalent inhibitor MI-2, labels both wild type and catalytically inactive Cys to Ala mutant Malt1, suggesting that MI-2 inhibits Malt1 by reacting with a nucleophilic residue other than the active site cysteine.	2-methyl-4-isothiazolin-3-one	64-66	MALT1 paracaspase	Homo sapiens	174-179
27126528-0	2016	Corin Levels in Patients With Acute MI: Do We Need More Tools for Risk Stratification?	2-methyl-4-isothiazolin-3-one	36-38	corin, serine peptidase	Homo sapiens	0-5
27145179-11	2016	Intravenous infusion of genetically modified miR-211 overexpressing MSCs conveys enhanced protection from adverse post-MI remodeling compared with unmodified MSCs.	2-methyl-4-isothiazolin-3-one	119-121	microRNA 211	Rattus norvegicus	45-52
27011383-6	2016	Uptake studies using human transporter-expressing cells revealed the saturable uptake of M-I for OATP1B3 with a Km of 2.13 mumol/L.	2-methyl-4-isothiazolin-3-one	89-92	solute carrier organic anion transporter family member 1B3	Homo sapiens	97-104
27108384-8	2016	CONCLUSION: MDM2 inhibition with MI-219 results in p53-dependent sensitization of prostate cancer cells to radiation, antiandrogen therapy, and the combination.	2-methyl-4-isothiazolin-3-one	33-35	MDM2 proto-oncogene	Homo sapiens	12-16
27108384-8	2016	CONCLUSION: MDM2 inhibition with MI-219 results in p53-dependent sensitization of prostate cancer cells to radiation, antiandrogen therapy, and the combination.	2-methyl-4-isothiazolin-3-one	33-35	tumor protein p53	Homo sapiens	51-54
27301136-5	2016	At slow speed the formation of liver fibrosis TNFalpha amounted to 1.5 (0.9-2.8) pg/mI, with a fast speed--2.3(1.4-8.2) pg/mI (p = 0.006).	2-methyl-4-isothiazolin-3-one	84-86	tumor necrosis factor	Homo sapiens	46-54
26790577-0	2016	Opinion of the Scientific Committee on Consumer safety (SCCS) - Opinion on the safety of the use of Methylisothiazolinone (MI) (P94), in cosmetic products (sensitisation only).	2-methyl-4-isothiazolin-3-one	100-121	calpain 3	Homo sapiens	128-131
26937175-5	2016	RESULTS AND CONCLUSION: We found that the MDM2 inhibitor MI-319 induced RCC cell apoptosis mainly dependent on p53 overexpression, while the mTOR antagonist rapamycin promoted RCC cell apoptosis primarily through upregulation of HIF1alpha expression.	2-methyl-4-isothiazolin-3-one	57-59	MDM2 proto-oncogene	Homo sapiens	42-46
26937175-5	2016	RESULTS AND CONCLUSION: We found that the MDM2 inhibitor MI-319 induced RCC cell apoptosis mainly dependent on p53 overexpression, while the mTOR antagonist rapamycin promoted RCC cell apoptosis primarily through upregulation of HIF1alpha expression.	2-methyl-4-isothiazolin-3-one	57-59	tumor protein p53	Homo sapiens	111-114
26937175-5	2016	RESULTS AND CONCLUSION: We found that the MDM2 inhibitor MI-319 induced RCC cell apoptosis mainly dependent on p53 overexpression, while the mTOR antagonist rapamycin promoted RCC cell apoptosis primarily through upregulation of HIF1alpha expression.	2-methyl-4-isothiazolin-3-one	57-59	hypoxia inducible factor 1 subunit alpha	Homo sapiens	229-238
27642598-10	2016	The elevated ROS production observed after short-term application of inhibitor MI-441 could be correlated with lowered hepcidin expression.	2-methyl-4-isothiazolin-3-one	79-81	hepcidin antimicrobial peptide	Homo sapiens	119-127
27301136-6	2016	Patients with UC at 3-4 degrees endo- scopic activity production of TNFalpha reached 6.5 (7-9) pg/mI, which was significantly higher than the value obtained at 1-2 degrees endoscopic activity--0.25(0-0.8) pg/ml (p = 0.001).	2-methyl-4-isothiazolin-3-one	98-100	tumor necrosis factor	Homo sapiens	68-76
27579037-3	2016	Myo (MI) and D-chiro-inositol (DCI), the most studied inositol isoforms, are classified as insulin sensitizers.	2-methyl-4-isothiazolin-3-one	5-7	insulin	Homo sapiens	91-98
27579037-6	2016	Considering the key role played by insulin-resistance and androgen excess in PCOS patients, the insulin-sensitizing effects of both MI and DCI were tested in order to ameliorate symptoms and signs of this syndrome, including the possibility to restore patients" fertility.	2-methyl-4-isothiazolin-3-one	132-134	insulin	Homo sapiens	96-103
27429622-3	2016	In this study, we observed that MI led to (i) a significant increase of the c-kit(+)AT2R(+) BMMNC subpopulation in mice and (ii) a modest increase of AT2R(+) BMMNCs in humans.	2-methyl-4-isothiazolin-3-one	32-34	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	76-81
27429622-8	2016	In conclusion, our results indicate that the c-kit(+)AT2R(+) BMMNC subpopulation exerts a protective effect against MI and shows promising therapeutic possibilities with regard to the treatment of ischemic heart disease.	2-methyl-4-isothiazolin-3-one	116-118	angiotensin II receptor, type 2	Rattus norvegicus	53-57
27429622-3	2016	In this study, we observed that MI led to (i) a significant increase of the c-kit(+)AT2R(+) BMMNC subpopulation in mice and (ii) a modest increase of AT2R(+) BMMNCs in humans.	2-methyl-4-isothiazolin-3-one	32-34	angiotensin II receptor, type 2	Rattus norvegicus	84-88
27429622-3	2016	In this study, we observed that MI led to (i) a significant increase of the c-kit(+)AT2R(+) BMMNC subpopulation in mice and (ii) a modest increase of AT2R(+) BMMNCs in humans.	2-methyl-4-isothiazolin-3-one	32-34	angiotensin II receptor, type 2	Rattus norvegicus	150-154
27429622-8	2016	In conclusion, our results indicate that the c-kit(+)AT2R(+) BMMNC subpopulation exerts a protective effect against MI and shows promising therapeutic possibilities with regard to the treatment of ischemic heart disease.	2-methyl-4-isothiazolin-3-one	116-118	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	45-50
26885264-5	2015	RESULTS: Compared with normal mice, mI/R elevated the levels of myocardial infarct size, apoptosis and TXNIP expression (in mRNA and protein) in diabetic mice.	2-methyl-4-isothiazolin-3-one	36-38	thioredoxin interacting protein	Mus musculus	103-108
26434201-7	2015	The median levels of the circulating hBD2 in the patients were 150.6 +/- 12.71 pg/ml vs. 262.1 +/- 23.82 pg/mI in the control group (p<0.0001).	2-methyl-4-isothiazolin-3-one	108-110	defensin beta 4A	Homo sapiens	37-41
26371341-16	2015	These findings demonstrate that early transient SPL inhibition after MI correlates with increased stem cell mobilization and their homing to the infarct border zones.	2-methyl-4-isothiazolin-3-one	69-71	plasma serotonin level	Mus musculus	48-51
26537714-8	2015	RESULTS: The values for %MI were as follows: P90 (100%) = TP3 (98.3%) = B (96.9%) > P25 (93.2%), (p<0.05).	2-methyl-4-isothiazolin-3-one	25-27	cellular inhibitor of PP2A	Homo sapiens	45-48
24330918-9	2015	Moreover, higher baseline HBP-accuracy was associated with significantly larger reductions in the scores of the ACQ and the MI-alone scales.	2-methyl-4-isothiazolin-3-one	124-126	heme binding protein 1	Homo sapiens	26-29
25757082-4	2015	OBJECTIVE: The aim of this study was to study the prevalence of methylchloroisothiazolinone/MI (MCI/MI) and MI allergy in a Bangkok dermatology clinic.	2-methyl-4-isothiazolin-3-one	92-94	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	96-102
25757082-9	2015	Among those who had a positive reaction to MI, 6 of 22 (27.3%) showed negative reaction to MCI/MI.	2-methyl-4-isothiazolin-3-one	43-45	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	91-97
24819287-1	2014	BACKGROUND: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and methylisothiazolinone (MI) contact allergies are rising dramatically.	2-methyl-4-isothiazolin-3-one	40-61	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	63-69
25618595-1	2015	We report herein the design and synthesis of bioisosteres of spirooxindole (MI-63/219), a small-molecule inhibitors of the MDM2-p53 interaction as anti-breast cancer agents.	2-methyl-4-isothiazolin-3-one	76-78	transformed mouse 3T3 cell double minute 2	Mus musculus	123-127
25618595-1	2015	We report herein the design and synthesis of bioisosteres of spirooxindole (MI-63/219), a small-molecule inhibitors of the MDM2-p53 interaction as anti-breast cancer agents.	2-methyl-4-isothiazolin-3-one	76-78	transformation related protein 53, pseudogene	Mus musculus	128-131
25116971-7	2014	CONCLUSIONS: In the TNF inhibitor cohort, those with psoriasis only have the strongest association with MI risk reduction, followed by those with psoriatic arthritis only, and then followed by those with both psoriasis and psoriatic arthritis.	2-methyl-4-isothiazolin-3-one	104-106	tumor necrosis factor	Homo sapiens	20-23
23713837-1	2013	BACKGROUND/OBJECTIVES: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is a preservative used in both cosmetic and industrial settings.	2-methyl-4-isothiazolin-3-one	51-72	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	74-80
24669277-14	2014	CONCLUSION: Intra-myocardial transplantation of adenovirus-ecSOD transfected BMSCs could exert potential cardiac protection against MI, which may be partly through reduction of oxidative stress and improvement of BMSCs survival.	2-methyl-4-isothiazolin-3-one	132-134	superoxide dismutase 3, extracellular	Mus musculus	59-64
24420805-1	2014	Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is a combination preservative used in personal care and household products and is a common cause of allergic contact dermatitis (ACD).	2-methyl-4-isothiazolin-3-one	28-49	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	51-54
23925934-8	2013	Oral treatment of NOD mice with CTB-2.5 mi failed to prevent diabetes.	2-methyl-4-isothiazolin-3-one	22-24	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	32-35
23358676-6	2013	These results indicate abnormal formation of the nAChR cluster in the NMJ of the masseter of mi/mi, suggesting that occlusion is essential for the normal progress of nAChR clustering in the NMJ of the masseter.	2-methyl-4-isothiazolin-3-one	96-98	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	49-54
24010369-13	2013	In the process of investigating these BC instruments, we learned that BC emissions at sub-1 mg/mi levels can be measured and are achievable by current-generation gasoline engines.	2-methyl-4-isothiazolin-3-one	74-76	SUB1 regulator of transcription	Homo sapiens	86-91
23358676-5	2013	In mice at 4 and 12 weeks of age, after the occlusion emerged in the +/+, excessive fragmentation and volume decline in the nAChR cluster were observed in the masseter of mi/mi fed a powdered diet compared with +/+ fed a pellet or powdered diet, whereas, in the gastrocnemius, no such differences were observed between the 2 strains.	2-methyl-4-isothiazolin-3-one	3-5	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	124-129
23358676-5	2013	In mice at 4 and 12 weeks of age, after the occlusion emerged in the +/+, excessive fragmentation and volume decline in the nAChR cluster were observed in the masseter of mi/mi fed a powdered diet compared with +/+ fed a pellet or powdered diet, whereas, in the gastrocnemius, no such differences were observed between the 2 strains.	2-methyl-4-isothiazolin-3-one	171-173	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	124-129
22818799-5	2012	When tested against purified recombinant HDACs, MI-192 had marked selectivity for the class I enzymes, HDAC2 and HDAC3.	2-methyl-4-isothiazolin-3-one	48-50	histone deacetylase 3	Homo sapiens	113-118
23358676-6	2013	These results indicate abnormal formation of the nAChR cluster in the NMJ of the masseter of mi/mi, suggesting that occlusion is essential for the normal progress of nAChR clustering in the NMJ of the masseter.	2-methyl-4-isothiazolin-3-one	93-95	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	49-54
23373862-8	2013	TPX1, a cell wall peroxidase specifically involved in lignification, was strongly repressed in GCs/galls, but induced in a nearly isogenic Mi-1 resistant line on nematode infection.	2-methyl-4-isothiazolin-3-one	139-141	thioredoxin peroxidase 1	Solanum lycopersicum	0-4
23957164-1	2013	The features of the impact of the maleimide derivative 1-(4-Cl-benzyl)-3-chloro-4-(CF3-fenilamino)-1H-pyrrole-2,5-dione (MI-1) on the viability and apoptosis-induced cell death of renal proximal and distal tubular epithelial cells and the amount of total and phosphorylated ERK1/2 were studied in order to establish possible mechanisms of nephrotoxicity induced by of MI-1.	2-methyl-4-isothiazolin-3-one	121-123	mitogen-activated protein kinase 3	Homo sapiens	274-280
22818799-5	2012	When tested against purified recombinant HDACs, MI-192 had marked selectivity for the class I enzymes, HDAC2 and HDAC3.	2-methyl-4-isothiazolin-3-one	48-50	histone deacetylase 2	Homo sapiens	103-108
22766116-8	2012	Global AS at baseline had a significantly close correlation with cTnI level 36 h after MI (r = 0.71, p < 0.001).	2-methyl-4-isothiazolin-3-one	87-89	troponin I3, cardiac type	Homo sapiens	65-69
23073812-9	2012	Compared with the MI group, the left ventricular end-systolic dimension, end-diastolic dimension, end-systolic volume and end-diastolic volume of the MI-B group were significantly decreased (P<0.01), while the left ventricular anterior wall end-diastolic thickness, ejection fraction and fractional shortening were obviously increased (P<0.01).	2-methyl-4-isothiazolin-3-one	18-20	piezo-type mechanosensitive ion channel component 1	Rattus norvegicus	150-154
22849963-7	2012	IP-10, MCP-4, and MIP-1beta were significantly associated with CMRs in the right basal ganglia with (1) lower concentrations of IP-10 correlating with higher N-acetyl aspartate to creatine ratios (NAA/Cr) and (2) higher concentrations of MCP-4 and MIP-1beta correlating with higher myoinositol to creatine (mI/Cr) ratios.	2-methyl-4-isothiazolin-3-one	307-309	C-X-C motif chemokine ligand 10	Homo sapiens	128-133
22532143-8	2012	CCN1 was upregulated in the MI group, while CCN2 remained at basal level.	2-methyl-4-isothiazolin-3-one	28-30	cyclin A2	Mus musculus	0-4
22050127-0	2012	Contact allergy to methylchoroisothiazolinone/methylisothiazolinone (MCI/MI): findings from a contact dermatitis unit.	2-methyl-4-isothiazolin-3-one	46-67	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	69-75
22050127-2	2012	However, only a few of them are strongly represented on the market: formaldehyde, parabens, formaldehyde releasers and methylchoroisothiazolinone/methylisothiazolinone (MCI/MI).	2-methyl-4-isothiazolin-3-one	146-167	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	169-175
22368415-6	2012	The incidence of ventricular fibrillation was significantly reduced by G-CSF (MI-Cont: 11.2 +- 2.4 vs. MI-GCSF: 5.4 +- 1 events; P < 0.05).	2-methyl-4-isothiazolin-3-one	78-80	colony stimulating factor 3	Rattus norvegicus	71-76
21883272-8	2012	RhAG expression was also significantly reduced in Mi.III(+/+), but not in Mi.III(+/-).	2-methyl-4-isothiazolin-3-one	50-52	Rh associated glycoprotein	Homo sapiens	0-4
21883272-0	2012	Expression of the Rh/RhAG complex is reduced in Mi.III erythrocytes.	2-methyl-4-isothiazolin-3-one	48-50	Rh associated glycoprotein	Homo sapiens	21-25
21883272-2	2012	The two alleles of glycophorin B are substituted with the B-A-B hybrid alleles in homozygous Mi.III (Mi.III(+/+)), and thus, Mi.III(+/+) erythrocytes lack glycophorin B (GPB) and express Gp.Mur only.	2-methyl-4-isothiazolin-3-one	93-95	glycophorin B (MNS blood group)	Homo sapiens	19-32
21883272-2	2012	The two alleles of glycophorin B are substituted with the B-A-B hybrid alleles in homozygous Mi.III (Mi.III(+/+)), and thus, Mi.III(+/+) erythrocytes lack glycophorin B (GPB) and express Gp.Mur only.	2-methyl-4-isothiazolin-3-one	101-103	glycophorin B (MNS blood group)	Homo sapiens	19-32
21558290-7	2012	The presence of anti-La/SSB antibody was significantly higher in the MS-KCS than the Mi-KCS group for total and primary SS.	2-methyl-4-isothiazolin-3-one	85-87	small RNA binding exonuclease protection factor La	Homo sapiens	21-27
22034127-3	2012	The expression levels of MyHC mRNA and protein in the masseter, temporalis, digastric, tibialis anterior and gastrocnemius muscles of +/+ and mi/mi mice were analysed with real-time polymerase chain reaction and sodium dodecyl sulfate-polyacrylamide gel electrophoresis, respectively.	2-methyl-4-isothiazolin-3-one	118-120	myosin heavy chain, cardiac muscle complex	Mus musculus	25-29
22034127-3	2012	The expression levels of MyHC mRNA and protein in the masseter, temporalis, digastric, tibialis anterior and gastrocnemius muscles of +/+ and mi/mi mice were analysed with real-time polymerase chain reaction and sodium dodecyl sulfate-polyacrylamide gel electrophoresis, respectively.	2-methyl-4-isothiazolin-3-one	142-144	myosin heavy chain, cardiac muscle complex	Mus musculus	25-29
21785345-18	2011	Moderate-intensity and high-intensity running upregulated the expression of VEGF protein and increased microvessels, which may have partly improved cardiac function after MI in this study.	2-methyl-4-isothiazolin-3-one	171-173	vascular endothelial growth factor A	Rattus norvegicus	76-80
21903177-5	2011	The results showed induction of both F(mi) and F(mu) by 2-NP and NDMA individually, and this effect was completely suppressed by relatively specific inhibitor of SULT1A1 and CYP2E1, i.e., pentachlorophenol and 1-aminobenzotriazole, respectively.	2-methyl-4-isothiazolin-3-one	39-41	sulfotransferase family 1A member 1	Homo sapiens	162-169
21903177-5	2011	The results showed induction of both F(mi) and F(mu) by 2-NP and NDMA individually, and this effect was completely suppressed by relatively specific inhibitor of SULT1A1 and CYP2E1, i.e., pentachlorophenol and 1-aminobenzotriazole, respectively.	2-methyl-4-isothiazolin-3-one	39-41	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	174-180
21929745-8	2011	In responsive cell lines, the MI-319/sorafenib combination induced the disappearance of p53 from the nucleus, the down modulation of Bcl-2 and Bcl-xL, the translocation of p53 to the mitochondria and that of AIF to the nuclei.	2-methyl-4-isothiazolin-3-one	30-32	tumor protein p53	Homo sapiens	88-91
21929745-8	2011	In responsive cell lines, the MI-319/sorafenib combination induced the disappearance of p53 from the nucleus, the down modulation of Bcl-2 and Bcl-xL, the translocation of p53 to the mitochondria and that of AIF to the nuclei.	2-methyl-4-isothiazolin-3-one	30-32	BCL2 apoptosis regulator	Homo sapiens	133-138
21929745-8	2011	In responsive cell lines, the MI-319/sorafenib combination induced the disappearance of p53 from the nucleus, the down modulation of Bcl-2 and Bcl-xL, the translocation of p53 to the mitochondria and that of AIF to the nuclei.	2-methyl-4-isothiazolin-3-one	30-32	BCL2 like 1	Homo sapiens	143-149
21929745-8	2011	In responsive cell lines, the MI-319/sorafenib combination induced the disappearance of p53 from the nucleus, the down modulation of Bcl-2 and Bcl-xL, the translocation of p53 to the mitochondria and that of AIF to the nuclei.	2-methyl-4-isothiazolin-3-one	30-32	tumor protein p53	Homo sapiens	172-175
21929745-10	2011	These modulatory effects of GSK-3beta on the activities of the sorafenib/MI-319 combination were the exact reverse of its effects on the activities of sorafenib alone, which induced the down modulation of Bcl-2 and Bcl-xL and the nuclear translocation of AIF only in cells in which GSK-3beta activity was either down modulated or constitutively low.	2-methyl-4-isothiazolin-3-one	73-75	glycogen synthase kinase 3 beta	Homo sapiens	28-37
21929745-10	2011	These modulatory effects of GSK-3beta on the activities of the sorafenib/MI-319 combination were the exact reverse of its effects on the activities of sorafenib alone, which induced the down modulation of Bcl-2 and Bcl-xL and the nuclear translocation of AIF only in cells in which GSK-3beta activity was either down modulated or constitutively low.	2-methyl-4-isothiazolin-3-one	73-75	BCL2 apoptosis regulator	Homo sapiens	205-210
21929745-10	2011	These modulatory effects of GSK-3beta on the activities of the sorafenib/MI-319 combination were the exact reverse of its effects on the activities of sorafenib alone, which induced the down modulation of Bcl-2 and Bcl-xL and the nuclear translocation of AIF only in cells in which GSK-3beta activity was either down modulated or constitutively low.	2-methyl-4-isothiazolin-3-one	73-75	BCL2 like 1	Homo sapiens	215-221
21929745-10	2011	These modulatory effects of GSK-3beta on the activities of the sorafenib/MI-319 combination were the exact reverse of its effects on the activities of sorafenib alone, which induced the down modulation of Bcl-2 and Bcl-xL and the nuclear translocation of AIF only in cells in which GSK-3beta activity was either down modulated or constitutively low.	2-methyl-4-isothiazolin-3-one	73-75	glycogen synthase kinase 3 beta	Homo sapiens	282-291
21977870-9	2011	RESULTS: Compared with the model group, the expression of VEGF and TGF-beta1, and the density of small arteries and the number of VEGF-positive blood vessels in the AI group and the MI group significantly increased (both P < 0.01).	2-methyl-4-isothiazolin-3-one	182-184	vascular endothelial growth factor A	Rattus norvegicus	58-62
21977870-9	2011	RESULTS: Compared with the model group, the expression of VEGF and TGF-beta1, and the density of small arteries and the number of VEGF-positive blood vessels in the AI group and the MI group significantly increased (both P < 0.01).	2-methyl-4-isothiazolin-3-one	182-184	vascular endothelial growth factor A	Rattus norvegicus	130-134
21977870-10	2011	Compared with the MI group, the density of small arteries and the number of VEGF-positive blood vessels in the AI group significantly increased (both P < 0.01); Compared with the model group and the normal control group, the serum expression quantity of NO and VEGF in the AI group and the MI group were significantly increased (P < 0.01).	2-methyl-4-isothiazolin-3-one	18-20	vascular endothelial growth factor A	Rattus norvegicus	76-80
21042943-7	2011	The proportion of luminal-like tumors decreased, whereas ERBB2+ and basal-like tumors increased in DCIS-I/DCIS-Mi compared with pure-DCIS (P = 0.039).	2-methyl-4-isothiazolin-3-one	111-113	erb-b2 receptor tyrosine kinase 2	Homo sapiens	57-62
21481032-2	2011	Here we show that a distinct member of the SERK family, SERK1, is required for the full functioning of Mi-1, a nucleotide binding leucine-rich repeat (NB-LRR) resistance protein.	2-methyl-4-isothiazolin-3-one	103-105	somatic embryogenesis receptor kinase 1	Solanum lycopersicum	56-61
21029112-3	2011	Here, we investigated whether the direct interaction between band 3 and Mi.III-specific Gp.Mur (a glycophorin B-A-B hybrid) might affect the expression of related blood group antigens such as the Wright b (Wr(b) ) antigen.	2-methyl-4-isothiazolin-3-one	72-74	guided entry of tail-anchored proteins factor 1	Homo sapiens	196-211
21350558-3	2011	The response to MI-219 is associated with the downregulation of c-Myc and the induction of p21(WAF1).	2-methyl-4-isothiazolin-3-one	16-18	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	64-69
21350558-3	2011	The response to MI-219 is associated with the downregulation of c-Myc and the induction of p21(WAF1).	2-methyl-4-isothiazolin-3-one	16-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	91-94
21350558-3	2011	The response to MI-219 is associated with the downregulation of c-Myc and the induction of p21(WAF1).	2-methyl-4-isothiazolin-3-one	16-18	cyclin dependent kinase inhibitor 1A	Homo sapiens	95-99
20224737-2	2010	By 8 weeks of age, MyHC I had nearly disappeared in the +/+ mice, while it was still present in the mi/mi, and the level of MyHC I mRNA in the mi/mi was 5.1-fold higher than that in the +/+ (p<0.01).	2-methyl-4-isothiazolin-3-one	60-62	myosin, heavy polypeptide 7, cardiac muscle, beta	Mus musculus	19-25
20713123-10	2010	These biochemical results are discussed in the light of the characteristics of the enzymatic phenotype of PH1 patients bearing G170R mutation in AGT-Mi and the positive response of these patients to pyridoxine treatment.	2-methyl-4-isothiazolin-3-one	149-151	angiotensinogen	Homo sapiens	145-148
20409007-10	2010	We propose that WRKY72-type transcription factors play a partially conserved role in basal defense in tomato and Arabidopsis, a function that has been recruited to serve Mi-1-dependent immunity.	2-methyl-4-isothiazolin-3-one	170-172	WRKY DNA-binding protein 72	Arabidopsis thaliana	16-22
20423286-3	2010	Cell lines naturally devoid of p53 or expressing shRNA targeting p53 are refractory to apoptosis induction by MI-63, indicating that the effects of MI-63 require p53 expression.	2-methyl-4-isothiazolin-3-one	148-150	tumor protein p53	Homo sapiens	65-68
20423286-3	2010	Cell lines naturally devoid of p53 or expressing shRNA targeting p53 are refractory to apoptosis induction by MI-63, indicating that the effects of MI-63 require p53 expression.	2-methyl-4-isothiazolin-3-one	148-150	tumor protein p53	Homo sapiens	65-68
20423286-4	2010	MI-63 induced G1 phase arrest and increased p21 expression.	2-methyl-4-isothiazolin-3-one	0-2	H3 histone pseudogene 16	Homo sapiens	44-47
20423286-7	2010	Interestingly, treatment with MI-63 also led to a reduction in levels of MDM4 protein, a repressor of p53 mediated transcription, in AML cells.	2-methyl-4-isothiazolin-3-one	30-32	MDM4 regulator of p53	Homo sapiens	73-77
20423286-7	2010	Interestingly, treatment with MI-63 also led to a reduction in levels of MDM4 protein, a repressor of p53 mediated transcription, in AML cells.	2-methyl-4-isothiazolin-3-one	30-32	tumor protein p53	Homo sapiens	102-105
21949693-7	2011	Followed ILK alternation, vascular endothelial growth factor (VEGF) expression and phosphorylation of endothelial nitric oxide synthase (eNOS) was significantly decreased 8 weeks after MI.	2-methyl-4-isothiazolin-3-one	185-187	integrin-linked kinase	Rattus norvegicus	9-12
21949693-7	2011	Followed ILK alternation, vascular endothelial growth factor (VEGF) expression and phosphorylation of endothelial nitric oxide synthase (eNOS) was significantly decreased 8 weeks after MI.	2-methyl-4-isothiazolin-3-one	185-187	vascular endothelial growth factor A	Rattus norvegicus	26-60
21949693-7	2011	Followed ILK alternation, vascular endothelial growth factor (VEGF) expression and phosphorylation of endothelial nitric oxide synthase (eNOS) was significantly decreased 8 weeks after MI.	2-methyl-4-isothiazolin-3-one	185-187	vascular endothelial growth factor A	Rattus norvegicus	62-66
19958544-5	2009	RESULTS: MI-319 was shown to bind to MDM2 protein with an affinity slightly higher than that of MI-219 and Nutlin-3.	2-methyl-4-isothiazolin-3-one	9-11	MDM2 proto-oncogene	Homo sapiens	37-41
19734467-4	2009	In the masseter of the mi/mi, the nAChR elimination initiated, but did not progress normally, after 3 weeks of age, when the occlusal activity emerged in the +/+ mouse, whereas the nAChR switch progressed normally during the entire period of synaptogenesis.	2-methyl-4-isothiazolin-3-one	23-25	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	34-39
19549525-9	2009	CONCLUSIONS: In intestinal smooth muscle cells TRPC4 and TRPC6 channels are gated by muscarinic receptors and are responsible for mI(CAT).	2-methyl-4-isothiazolin-3-one	130-132	transient receptor potential cation channel, subfamily C, member 4	Mus musculus	47-52
19549525-9	2009	CONCLUSIONS: In intestinal smooth muscle cells TRPC4 and TRPC6 channels are gated by muscarinic receptors and are responsible for mI(CAT).	2-methyl-4-isothiazolin-3-one	130-132	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	57-62
19564639-5	2009	In accordance with the higher AE1 level, the Mi.III(+) erythrocytes exhibited superior HCO(3)(-) capacities, pH homeostasis, and osmotic resistance.	2-methyl-4-isothiazolin-3-one	45-47	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	30-33
19564639-7	2009	In summary, the increased surface expression of AE1 in Mi.III(+) erythrocytes could be attributed to the additive effect of GPA and Gp.Mur coexpression.	2-methyl-4-isothiazolin-3-one	55-57	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	48-51
19734467-4	2009	In the masseter of the mi/mi, the nAChR elimination initiated, but did not progress normally, after 3 weeks of age, when the occlusal activity emerged in the +/+ mouse, whereas the nAChR switch progressed normally during the entire period of synaptogenesis.	2-methyl-4-isothiazolin-3-one	23-25	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	181-186
19734467-4	2009	In the masseter of the mi/mi, the nAChR elimination initiated, but did not progress normally, after 3 weeks of age, when the occlusal activity emerged in the +/+ mouse, whereas the nAChR switch progressed normally during the entire period of synaptogenesis.	2-methyl-4-isothiazolin-3-one	26-28	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	34-39
19734467-4	2009	In the masseter of the mi/mi, the nAChR elimination initiated, but did not progress normally, after 3 weeks of age, when the occlusal activity emerged in the +/+ mouse, whereas the nAChR switch progressed normally during the entire period of synaptogenesis.	2-methyl-4-isothiazolin-3-one	26-28	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	181-186
24256959-4	2008	While single voxel proton spectroscopy (MRS) of the basal ganglia at the beginning was normal, the follow-up MRS showed moderate to severe NAA and mI decrease.	2-methyl-4-isothiazolin-3-one	147-149	MROS	Homo sapiens	109-112
19155213-4	2009	AGT-Mi causes the PH1 disease only when combined with some mutations.	2-methyl-4-isothiazolin-3-one	4-6	alanine--glyoxylate and serine--pyruvate aminotransferase	Homo sapiens	0-3
18837981-6	2008	The frequency of necrosis and positive expression ratio of survivin and Bax were significantly higher in DCIS-Mi than in DCIS.	2-methyl-4-isothiazolin-3-one	110-112	BCL2 associated X, apoptosis regulator	Homo sapiens	72-75
18180401-1	2008	We have shown previously that cyclooxygenase-2 inhibition reduces cardiac hypertrophy and fibrosis postmyocardial infarction (MI) in a mouse model and that prostaglandin E(2) stimulates cardiomyocyte hypertrophy in vitro through its EP(4) receptor.	2-methyl-4-isothiazolin-3-one	126-128	prostaglandin-endoperoxide synthase 2	Mus musculus	30-46
18625233-7	2008	DRB2, DRB3 and DRB5 appear unnecessary for mi-, tasi-, viral si-, or heterochromatinising siRNA production but act redundantly in a developmental pathway.	2-methyl-4-isothiazolin-3-one	43-45	dsRNA-binding protein 2	Arabidopsis thaliana	0-4
18676549-5	2008	RESULTS: Insulin sensitivity expressed as Mi value (glucose disposal mg/kg/min (insulin levels pmol/l) x 100) was lower in infants in the POPS-AGA (18.2) and POPS-SGA (15.2) groups than in the CON group (24.7).	2-methyl-4-isothiazolin-3-one	42-44	insulin	Homo sapiens	9-16
18676549-5	2008	RESULTS: Insulin sensitivity expressed as Mi value (glucose disposal mg/kg/min (insulin levels pmol/l) x 100) was lower in infants in the POPS-AGA (18.2) and POPS-SGA (15.2) groups than in the CON group (24.7).	2-methyl-4-isothiazolin-3-one	42-44	insulin	Homo sapiens	80-87
18525383-8	2008	RESULTS: Seven weeks after left anterior descending artery ligation (myocardial infarction) the messenger RNA expression of Murf-1 (sham: 1.8+/-0.3 vs. Mi: 5.9+/-1.2 arb.	2-methyl-4-isothiazolin-3-one	152-154	tripartite motif containing 63	Rattus norvegicus	124-130
17438000-0	2007	CHD4/Mi-2beta activity is required for the positioning of the mesoderm/neuroectoderm boundary in Xenopus.	2-methyl-4-isothiazolin-3-one	5-7	chromodomain helicase DNA binding protein 4 L homeolog	Xenopus laevis	0-4
17434994-0	2007	Comprehensive transcriptome profiling in tomato reveals a role for glycosyltransferase in Mi-mediated nematode resistance.	2-methyl-4-isothiazolin-3-one	90-92	glycosyltransferase	Solanum lycopersicum	67-86
16547166-0	2006	Methylisothiazolinone, a neurotoxic biocide, disrupts the association of SRC family tyrosine kinases with focal adhesion kinase in developing cortical neurons.	2-methyl-4-isothiazolin-3-one	0-21	FYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	73-76
17105730-9	2007	The expression of Clcn7 is repressed in the dominant negative mutant Mitf mouse, mi/mi, indicating that the dysregulated bone resorption seen in these mice can be attributed in part to transcriptional repression of Clcn7.	2-methyl-4-isothiazolin-3-one	46-48	chloride channel, voltage-sensitive 7	Mus musculus	18-23
17012328-5	2006	The fluorescence data correlate with the pK(a) for the MI-to-MII transition of rhodopsin, where deprotonation of the retinylidene Schiff base occurs in conjunction with helical movements leading to activation of the photoreceptor.	2-methyl-4-isothiazolin-3-one	55-57	rhodopsin	Homo sapiens	79-88
16789975-9	2006	In the elderly, ECG abnormalities did not contribute to the prediction of myocardial infarction but smoking and fasting insulin may be important in the pathophysiology leading to MI especially in this age group.	2-methyl-4-isothiazolin-3-one	179-181	insulin	Homo sapiens	120-127
16918615-0	2006	An evaluation of dose/unit area and time as key factors influencing the elicitation capacity of methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in MCI/MI-allergic patients.	2-methyl-4-isothiazolin-3-one	124-145	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	147-150
16918615-0	2006	An evaluation of dose/unit area and time as key factors influencing the elicitation capacity of methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in MCI/MI-allergic patients.	2-methyl-4-isothiazolin-3-one	124-145	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	158-161
16918615-1	2006	Methylchloroisothiazolinone and methylisothiazolinone (MCI/MI) contact allergy affects 1-3% of patch-tested patients in European centres.	2-methyl-4-isothiazolin-3-one	32-53	multiciliate differentiation and DNA synthesis associated cell cycle protein	Homo sapiens	55-58
16856597-3	2006	Expression of the myosin heavy chain (MyHC)-2a protein, whose contraction speed is relatively slow, disappeared after weaning in normal mice, while it remained in high concentrations even after weaning in mi/mi mice.	2-methyl-4-isothiazolin-3-one	136-138	myosin, heavy polypeptide 2, skeletal muscle, adult	Mus musculus	18-46
16856597-3	2006	Expression of the myosin heavy chain (MyHC)-2a protein, whose contraction speed is relatively slow, disappeared after weaning in normal mice, while it remained in high concentrations even after weaning in mi/mi mice.	2-methyl-4-isothiazolin-3-one	205-207	myosin, heavy polypeptide 2, skeletal muscle, adult	Mus musculus	18-46
16547166-0	2006	Methylisothiazolinone, a neurotoxic biocide, disrupts the association of SRC family tyrosine kinases with focal adhesion kinase in developing cortical neurons.	2-methyl-4-isothiazolin-3-one	0-21	protein tyrosine kinase 2	Rattus norvegicus	106-127
15993438-2	2005	We tested if the enhancement of the mI(AHP) by 1-ethyl-2-benzimidazolinone (EBIO) could suppress epileptiform activity in two in vitro models of epileptogenesis induced in CA3 hippocampal pyramidal neurons by superfusion with 4-AP- and kainate-Mg2+-free solutions.	2-methyl-4-isothiazolin-3-one	36-38	carbonic anhydrase 3	Homo sapiens	172-175
16756774-11	2006	CONCLUSION: Using this model, it was found that nimesulide, a COX-2 inhibitor, exerted a cardioprotective effects in MI.	2-methyl-4-isothiazolin-3-one	117-119	prostaglandin G/H synthase 2	Oryctolagus cuniculus	62-67
15550785-16	2004	TNF-alpha staining in the noninfarcted region was evident only in the MI groups, not the sham group.	2-methyl-4-isothiazolin-3-one	70-72	tumor necrosis factor	Rattus norvegicus	0-9
15492754-2	2005	The mi mutant allele encodes an abnormal MITF, in which one out of four consecutive arginines is deleted in the basic domain.	2-methyl-4-isothiazolin-3-one	4-6	melanogenesis associated transcription factor	Mus musculus	41-45
15492754-7	2005	The abnormal NK cell and macrophage of B6-mi/mi mice appear to be due to decreased expression of the IL-12Rbeta2 and IL-18Ralpha genes.	2-methyl-4-isothiazolin-3-one	42-44	interleukin 18 receptor 1	Mus musculus	117-128
15492754-7	2005	The abnormal NK cell and macrophage of B6-mi/mi mice appear to be due to decreased expression of the IL-12Rbeta2 and IL-18Ralpha genes.	2-methyl-4-isothiazolin-3-one	45-47	interleukin 18 receptor 1	Mus musculus	117-128
15108597-7	2004	From these results we deduce that MI can be instrumental in monitoring adaptation to the sea duties as it permits determine the physiological adaptability of seamen and dynamics of the body adjustment.	2-methyl-4-isothiazolin-3-one	34-36	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	89-92
15071488-6	2004	Delapril monotherapy significantly decreased plasma PAI-l activity (-10.4 IU/mI; P<0.05).	2-methyl-4-isothiazolin-3-one	77-79	serpin family E member 1	Homo sapiens	52-55
15071488-7	2004	The addition of manidipine produced a significant increase in t-PA activity (+0.27 IU/mI); P<0.05).	2-methyl-4-isothiazolin-3-one	86-88	plasminogen activator, tissue type	Homo sapiens	62-66
15248695-3	2004	At a fixed total salt concentration, the sol-gel transition temperature nicely followed a rule of mixing: Tp = m1Tp1 + m2Tp2 where Tp, Tp1, and Tp2 are the gelation peak temperatures for the MC solutions with a salt mixture, NaCl, and NaI, respectively, and mi is the molar fraction of the salt component i in the salt mixture.	2-methyl-4-isothiazolin-3-one	98-100	transition protein 1	Homo sapiens	113-116
15248695-3	2004	At a fixed total salt concentration, the sol-gel transition temperature nicely followed a rule of mixing: Tp = m1Tp1 + m2Tp2 where Tp, Tp1, and Tp2 are the gelation peak temperatures for the MC solutions with a salt mixture, NaCl, and NaI, respectively, and mi is the molar fraction of the salt component i in the salt mixture.	2-methyl-4-isothiazolin-3-one	98-100	transition protein 2	Homo sapiens	121-124
14608014-1	2004	We examined the effects of changes in pH(o) and pH(i) on currents contributing to the medium and slow afterhyperpolarizations (mI(AHP) and sI(AHP), respectively) in rat CA1 neurones.	2-methyl-4-isothiazolin-3-one	127-129	carbonic anhydrase 1	Rattus norvegicus	169-172
14608014-8	2004	Together, the results indicate that changes in pH(o) and pH(i) modulate mI(AHP) and sI(AHP) in rat CA1 neurones and suggest that, depending on the direction of the pH(o) change, the sensitivities of the underlying currents to changes in Ca(2+) influx and/or pH(i) may contribute to the effects of changes in pH(o) to modulate mI(AHP) and sI(AHP).	2-methyl-4-isothiazolin-3-one	72-74	carbonic anhydrase 1	Rattus norvegicus	99-102
14674894-0	2003	Methylisothiazolinones elicit increased production of both T helper (Th)1- and Th2-like cytokines by peripheral blood mononuclear cells from contact allergic individuals.	2-methyl-4-isothiazolin-3-one	0-22	negative elongation factor complex member C/D	Homo sapiens	59-74
14584903-3	2003	These are of relevance to osteoclast biology because the PU.1 knockout mouse has an osteopetrotic phenotype, and MiTF, when mutated in the mi/mi mouse, also results in osteopetrosis.	2-methyl-4-isothiazolin-3-one	139-141	melanogenesis associated transcription factor	Mus musculus	113-117
14584903-3	2003	These are of relevance to osteoclast biology because the PU.1 knockout mouse has an osteopetrotic phenotype, and MiTF, when mutated in the mi/mi mouse, also results in osteopetrosis.	2-methyl-4-isothiazolin-3-one	142-144	melanogenesis associated transcription factor	Mus musculus	113-117
12393515-9	2003	The KL-1/KL-2 ratio was higher in WB-mi/mi than in B6-mi/mi mice, suggesting that the larger amount of soluble KitL may compensate for the reduced expression of KIT in WB-mi/mi mice.	2-methyl-4-isothiazolin-3-one	37-39	kit ligand	Mus musculus	111-115
12393515-9	2003	The KL-1/KL-2 ratio was higher in WB-mi/mi than in B6-mi/mi mice, suggesting that the larger amount of soluble KitL may compensate for the reduced expression of KIT in WB-mi/mi mice.	2-methyl-4-isothiazolin-3-one	40-42	kit ligand	Mus musculus	111-115
12393515-9	2003	The KL-1/KL-2 ratio was higher in WB-mi/mi than in B6-mi/mi mice, suggesting that the larger amount of soluble KitL may compensate for the reduced expression of KIT in WB-mi/mi mice.	2-methyl-4-isothiazolin-3-one	40-42	kit ligand	Mus musculus	111-115
12393515-9	2003	The KL-1/KL-2 ratio was higher in WB-mi/mi than in B6-mi/mi mice, suggesting that the larger amount of soluble KitL may compensate for the reduced expression of KIT in WB-mi/mi mice.	2-methyl-4-isothiazolin-3-one	40-42	kit ligand	Mus musculus	111-115
12393515-9	2003	The KL-1/KL-2 ratio was higher in WB-mi/mi than in B6-mi/mi mice, suggesting that the larger amount of soluble KitL may compensate for the reduced expression of KIT in WB-mi/mi mice.	2-methyl-4-isothiazolin-3-one	40-42	kit ligand	Mus musculus	111-115
12651810-14	2003	However, the Co(II)-albumin binding was a poor discriminator between ischemic individuals with and without MI.	2-methyl-4-isothiazolin-3-one	107-109	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-19