PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 7410412-2 1980 The (-)-enantiomer of benzo[a]pyrene 7,8-oxide is metabolized by microsomal epoxide hydrolase at a rate 3- to 4-fold greater than the (+)-enantiomer. benzo(a)pyrene 7,8-oxide 22-46 epoxide hydrolase 1, microsomal Mus musculus 65-93 12051674-4 2002 To clarify the influences of P450 enzymes on the catalytic activity of mEH, the hydrolyzing activity for styrene oxide and benzo(a)pyrene-7,8-oxide [B(a)P-oxide] was analyzed in the presence or absence of P450s. benzo(a)pyrene 7,8-oxide 123-147 epoxide hydrolase 1, microsomal Mus musculus 71-74 8585611-1 1995 The microfluorometric assay, suitable for measuring microsomal epoxide hydrolase activity in cultured cells, is based on the conversion of benzo[a]pyrene-7,8-epoxide to the corresponding trans-benzo[a]pyrene-7,8-dihydrodiol, a compound that fluoresces at 403 nm when excited at 365 nm. benzo(a)pyrene 7,8-oxide 139-165 epoxide hydrolase 1 Homo sapiens 52-80 821945-12 1976 Benzo (a)pyrene 7,8-oxide, a carcinogen on mouse skin, is weakly mutagenic but can be further metabolized to a highly active bacterial mutagen(s), presumably diol epoxide(s), by a combination of epoxide hydrase and the cytochrome P-448 monooxygenase system. benzo(a)pyrene 7,8-oxide 0-25 cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus 219-235