PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23363694-4	2012	Novel 2-(quinolin-3-yl)acetic acid derivatives (LEDGINs), agents that were originally thought to inhibit the interaction of integrase with its cofactor lens epithelium-derived growth factor p75 (LEDGF/p75), be active against InSTI-resistant mutants and to have additive activity when combined with InSTIs.	2-(QUINOLIN-3-YL)ACETIC ACID	6-34	PC4 and SFRS1 interacting protein 1	Homo sapiens	195-204
22664975-2	2012	We have previously described the discovery of a novel class of integration inhibitors, 2-(quinolin-3-yl)acetic acid derivatives, blocking HIV replication at a low micromolar concentration through binding in the LEDGF/p75 binding pocket of HIV integrase, hence referred to as LEDGINs.	2-(QUINOLIN-3-YL)ACETIC ACID	87-115	PC4 and SFRS1 interacting protein 1	Homo sapiens	211-220
20473303-3	2010	We have rationally designed a series of 2-(quinolin-3-yl)acetic acid derivatives (LEDGINs) that act as potent inhibitors of the LEDGF/p75-integrase interaction and HIV-1 replication at submicromolar concentration by blocking the integration step.	2-(QUINOLIN-3-YL)ACETIC ACID	40-68	PC4 and SFRS1 interacting protein 1	Homo sapiens	128-137