PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
23352139-4	2013	We present ML216, a potent inhibitor of the DNA unwinding activity of BLM.	ML216	11-16	BLM RecQ like helicase	Homo sapiens	70-73
23352139-5	2013	ML216 shows cell-based activity and can induce sister chromatid exchanges, enhance the toxicity of aphidicolin, and exert antiproliferative activity in cells expressing BLM, but not those lacking BLM.	ML216	0-5	BLM RecQ like helicase	Homo sapiens	169-172
23352139-5	2013	ML216 shows cell-based activity and can induce sister chromatid exchanges, enhance the toxicity of aphidicolin, and exert antiproliferative activity in cells expressing BLM, but not those lacking BLM.	ML216	0-5	BLM RecQ like helicase	Homo sapiens	196-199
34846107-1	2021	OBJECTIVE: We aimed to investigate the radiosensitizing efficacy of the poly-ADP-ribose polymerase (PARP) inhibitor, olaparib, and the Bloom syndrome protein (BLM) helicase inhibitor, ML216, in non-small cell lung cancer (NSCLC) cells.	ML216	184-189	BLM RecQ like helicase	Homo sapiens	135-157
34846107-1	2021	OBJECTIVE: We aimed to investigate the radiosensitizing efficacy of the poly-ADP-ribose polymerase (PARP) inhibitor, olaparib, and the Bloom syndrome protein (BLM) helicase inhibitor, ML216, in non-small cell lung cancer (NSCLC) cells.	ML216	184-189	BLM RecQ like helicase	Homo sapiens	159-162
34846107-4	2021	RESULTS: Both olaparib and ML216 enhanced the radiosensitivities of olaparib-sensitive H460 and H1299 cells, which was seen as decreased surviving fractions and Rad51 foci, increased total DNA damage, and gammaH2AX and 53BP1 foci (P < 0.05).	ML216	27-32	RAD51 recombinase	Homo sapiens	161-166
34846107-6	2021	In addition to increases of double strand break (DSB) damage and decreases of Rad51 foci, olaparib combined with ML216 also increased pDNA-PKcs (S2056) foci, abrogated G2 cell cycle arrest, and induced apoptosis in A549 lung cancer after irradiation in vitro and in vivo (P < 0.05).	ML216	113-118	RAD51 recombinase	Homo sapiens	78-83