PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2783163-8 1989 Two other trichothecene toxins, one more and one less toxic than T-2, blocked labeled T-2 binding to cells in a manner reflective of their protein synthesis inhibitory potencies. Trichothecenes 10-23 solute carrier family 25 member 5 Homo sapiens 65-68 2783163-8 1989 Two other trichothecene toxins, one more and one less toxic than T-2, blocked labeled T-2 binding to cells in a manner reflective of their protein synthesis inhibitory potencies. Trichothecenes 10-23 solute carrier family 25 member 5 Homo sapiens 86-89 3055430-9 1988 The results suggest that bacterial LPS and trichothecenes such as T-2 toxin interact synergistically. Trichothecenes 43-57 brachyury 2 Mus musculus 66-69 2752183-1 1989 VIII--Thermospray ionization and collisionally activated dissociation of macrocyclic trichothecenes. Trichothecenes 85-99 cytochrome c oxidase subunit 8A Homo sapiens 0-4 2786491-6 1989 Hepatic microsomal cytochrome P-450 decreased in rats receiving trichothecenes for 8 days. Trichothecenes 64-78 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 19-35 3623344-1 1987 Gas-liquid chromatography was used to investigate the hepatic and intestinal metabolism of T-2 toxin, a cytotoxic and immunodepressive trichothecene produced by species of Fusarium. Trichothecenes 135-148 brachyury 2 Mus musculus 91-94 3248496-0 1988 [Mutagenicity and carcinogenicity of T-2 toxin, a trichothecene produced by Fusarium fungi]. Trichothecenes 50-63 brachyury 2 Rattus norvegicus 37-40 3435145-1 1987 The production of deepoxy metabolites of the trichothecene mycotoxins T-2 toxin and diacetoxyscirpenol, including deepoxy HT-2 (DE HT-2), deepoxy T-2 triol, deepoxy T-2 tetraol, deepoxy 15-monoacetoxyscirpenol, and deepoxy scirpentriol is described. Trichothecenes 45-58 hypothermia due to alcohol sensitivity 2 Mus musculus 122-126 3435145-1 1987 The production of deepoxy metabolites of the trichothecene mycotoxins T-2 toxin and diacetoxyscirpenol, including deepoxy HT-2 (DE HT-2), deepoxy T-2 triol, deepoxy T-2 tetraol, deepoxy 15-monoacetoxyscirpenol, and deepoxy scirpentriol is described. Trichothecenes 45-58 hypothermia due to alcohol sensitivity 2 Mus musculus 131-135 3660430-0 1987 Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis. Trichothecenes 60-73 PCNA clamp associated factor Homo sapiens 23-26 6234781-0 1983 Metabolization of trichothecene toxins (T-2 toxin and diacetoxyscirpenol) in embryonated hen"s egg. Trichothecenes 18-31 solute carrier family 25 member 5 Homo sapiens 40-43 3660984-0 1987 [The genotoxic effects of T-2 toxin, a trichothecene produced by fusarium fungi]. Trichothecenes 39-52 solute carrier family 25 member 5 Homo sapiens 26-29 3571109-3 1987 The positive ion chemical ionization mass spectra indicated that these compounds were trichothecene homologs lacking a methyl group on the isovaleroxy substituent at the C-8 position. Trichothecenes 86-99 homeobox C8 Homo sapiens 170-173 3462193-1 1986 T-2 toxin is an important representative of trichothecenes produced by various species of imperfect fungi, mainly Fusarium genus. Trichothecenes 44-58 solute carrier family 25 member 5 Homo sapiens 0-3 3866515-1 1985 Modification at the C-3 position of the trichothecenes T-2 and T-2 tetraol affected their ability to inhibit protein synthesis in African green monkey kidney (Vero) and mouse erythroleukemia cells. Trichothecenes 40-54 solute carrier family 25 member 5 Homo sapiens 55-58 6609858-0 1984 Toxicological features of T-2 toxin and related trichothecenes. Trichothecenes 48-62 brachyury 2 Mus musculus 26-29 6384590-0 1984 Decreased resistance to mycobacterial infection in mice fed a trichothecene compound (T-2 toxin). Trichothecenes 62-75 brachyury 2 Mus musculus 86-89 6384590-1 1984 The effect of T-2 toxin, a trichothecene compound, on bacterial infection was examined in mice infected intravenously with mycobacteria. Trichothecenes 27-40 brachyury 2 Mus musculus 14-17 6363056-1 1984 T-2 toxin, a metabolite of several Fusarium species, is a mycotoxin of the trichothecene family which occurs in a variety of grains. Trichothecenes 75-88 brachyury 2 Rattus norvegicus 0-3 6242274-0 1984 Production of T-2 toxin and related trichothecenes on different media. Trichothecenes 36-50 solute carrier family 25 member 5 Homo sapiens 14-17 6535466-0 1984 Toxicological properties of T-2 toxin and related trichothecenes. Trichothecenes 50-64 solute carrier family 25 member 5 Homo sapiens 28-31 7080066-0 1982 Blood pressure changes and cardiovascular lesions found in rats given T-2 toxin, a trichothecene secondary metabolite of certain Fusarium microfungi. Trichothecenes 83-96 brachyury 2 Rattus norvegicus 70-73 7160825-8 1982 The cross reactivity of T-2 toxin antiserum with other trichothecenes, as determined by ELISA, is weaker than that reported by other authors using a radio-immunoassay technique. Trichothecenes 55-69 solute carrier family 25 member 5 Homo sapiens 24-27 597234-6 1977 The inhibitory action observed in every case was controlled by the chemical structure of the individual trichothecene and in particular was closely related to the nature of the substituent groups present on C-3, C-4, C-8 and C-15 of the molecule. Trichothecenes 104-117 complement C3 Homo sapiens 207-210 445416-0 1979 Cardiovascular lesions and various tumors found in rats given T-2 toxin, a trichothecene metabolite of Fusarium. Trichothecenes 75-88 brachyury 2 Rattus norvegicus 62-65 721800-8 1978 It follow from these results that the C-4 acetyl residue is hydrolyzed by the microsomal carboxyesterase and substituents at C-3 and C-8 contribute to the selective enzymatic hydrolysis of the C-4 acetyl residue of trichothecenes. Trichothecenes 215-229 complement C3 alpha chain Oryctolagus cuniculus 125-128 658295-1 1978 T-2 toxin, a trichothecene metabolite of several Fusarium spp. Trichothecenes 13-26 brachyury 2 Mus musculus 0-3 597234-6 1977 The inhibitory action observed in every case was controlled by the chemical structure of the individual trichothecene and in particular was closely related to the nature of the substituent groups present on C-3, C-4, C-8 and C-15 of the molecule. Trichothecenes 104-117 complement C4A (Rodgers blood group) Homo sapiens 212-215 597234-6 1977 The inhibitory action observed in every case was controlled by the chemical structure of the individual trichothecene and in particular was closely related to the nature of the substituent groups present on C-3, C-4, C-8 and C-15 of the molecule. Trichothecenes 104-117 homeobox C8 Homo sapiens 217-220 32326355-7 2020 Both trichothecenes also enhanced transcript levels of the known NF-kappaB-dependent pro-inflammatory cytokines IL-8, IL-6, TNF-alpha and IL-1beta. Trichothecenes 5-19 nuclear factor kappa B subunit 1 Homo sapiens 65-74 5064093-1 1972 A modified rat skin test based on dermatitic properties of trichothecenes is described which is quick, convenient, and sensitive to 0.05 mug of T-2 toxin. Trichothecenes 59-73 brachyury 2 Rattus norvegicus 144-147 32187393-1 2020 T-2 toxin is one of the most toxic trichothecenes and harmful to human health and animal husbandry. Trichothecenes 35-49 acetyl-CoA acetyltransferase 1 Homo sapiens 0-3 613939-4 1977 Orally administered trichothecenes are rapidly absorbed and eliminated into the feces and urine upon deacetylation at C-4 by the microsomal esterase of liver. Trichothecenes 20-34 complement C4A (Rodgers blood group) Homo sapiens 118-121 1185900-9 1975 Mycotoxicological significance of T-2 toxin and related trichothecenes is discussed in relation to the food-borne diseases in humans and farm animals. Trichothecenes 56-70 solute carrier family 25 member 5 Homo sapiens 34-37 32171072-9 2020 In conclusion, our findings demonstrate that TNF-alpha and IL-1beta act critical roles in type B trichothecenes-induced anorexic response. Trichothecenes 97-111 tumor necrosis factor Homo sapiens 45-54 32171072-9 2020 In conclusion, our findings demonstrate that TNF-alpha and IL-1beta act critical roles in type B trichothecenes-induced anorexic response. Trichothecenes 97-111 interleukin 1 alpha Homo sapiens 59-67 32326355-7 2020 Both trichothecenes also enhanced transcript levels of the known NF-kappaB-dependent pro-inflammatory cytokines IL-8, IL-6, TNF-alpha and IL-1beta. Trichothecenes 5-19 C-X-C motif chemokine ligand 8 Homo sapiens 112-116 32326355-7 2020 Both trichothecenes also enhanced transcript levels of the known NF-kappaB-dependent pro-inflammatory cytokines IL-8, IL-6, TNF-alpha and IL-1beta. Trichothecenes 5-19 interleukin 6 Homo sapiens 118-122 32326355-7 2020 Both trichothecenes also enhanced transcript levels of the known NF-kappaB-dependent pro-inflammatory cytokines IL-8, IL-6, TNF-alpha and IL-1beta. Trichothecenes 5-19 tumor necrosis factor Homo sapiens 124-133 32326355-7 2020 Both trichothecenes also enhanced transcript levels of the known NF-kappaB-dependent pro-inflammatory cytokines IL-8, IL-6, TNF-alpha and IL-1beta. Trichothecenes 5-19 interleukin 1 alpha Homo sapiens 138-146 31886226-1 2019 T-2 toxin is a trichothecene mycotoxin produced by fungi which are known to contaminate cereals, especially in wheat and corn. Trichothecenes 15-28 solute carrier family 25 member 5 Homo sapiens 0-3 31844896-2 2020 Here, MAPKKK gamma-1 (MKD1), a novel Raf-like MAPKKK, was isolated as a subunit of a complex including the Arabidopsis transcription factor AtNFXL1, which is involved in the trichothecene phytotoxin response and in disease resistance against the bacterial pathogen Pseudomonas syringae pv. Trichothecenes 174-187 NF-X-like 1 Arabidopsis thaliana 140-147 31981685-1 2020 T-2 toxin, A trichothecenes mycotoxin, is immunotoxic to animals and humans. Trichothecenes 13-27 solute carrier family 25 member 5 Homo sapiens 0-3 31906162-1 2019 T-2 toxin, the most toxic member of trichothecene mycotoxin, is widely distributed in cereals, and has been extensively studied, but few studies focus on the toxicity of maternal exposure to offspring. Trichothecenes 36-49 brachyury 2 Mus musculus 0-3 32178237-1 2020 Among foodborne toxicities, the T-2 toxin is the most toxic member of trichothecenes mycotoxins, which has been shown to impair the development and reproductive efficiency of animals. Trichothecenes 70-84 brachyury 2 Mus musculus 32-35 31790345-6 2020 Previous work indicates that the NFXL1 ortholog represses trichothecene-induced defense responses and bacterial resistance in Arabidopsis but the role of the NFXL family has not been studied in wheat. Trichothecenes 58-71 NF-X-like 1 Arabidopsis thaliana 33-38 32013230-1 2020 T-2 toxin is type A trichothecenes mycotoxin, which produced by fusarium species in cereal grains. Trichothecenes 20-34 solute carrier family 25 member 5 Homo sapiens 0-3 31895560-1 2020 T-2 toxin, an inevitable environmental pollutant, is the most toxic type A trichothecene mycotoxin. Trichothecenes 75-88 solute carrier family 25 member 5 Homo sapiens 0-3 30243968-6 2018 The indirect action of trichothecenes in the gastrointestinal tract involved, by enteroendocrine cells, the secretion of several gut hormones such as cholecystokinin (CCK) and peptide YY (PYY) but also glucagon-like peptide 1 (GLP-1), gastric inhibitory peptide (GIP) and 5-hydroxytryptamine (5-HT), which transmitted signals to the brain via the gut-brain axis. Trichothecenes 23-37 cholecystokinin Homo sapiens 167-170 31570981-3 2019 T-2 toxin is one of the most common and toxic trichothecene mycotoxins. Trichothecenes 46-59 solute carrier family 25 member 5 Homo sapiens 0-3 30243968-6 2018 The indirect action of trichothecenes in the gastrointestinal tract involved, by enteroendocrine cells, the secretion of several gut hormones such as cholecystokinin (CCK) and peptide YY (PYY) but also glucagon-like peptide 1 (GLP-1), gastric inhibitory peptide (GIP) and 5-hydroxytryptamine (5-HT), which transmitted signals to the brain via the gut-brain axis. Trichothecenes 23-37 peptide YY Homo sapiens 176-186 30243968-6 2018 The indirect action of trichothecenes in the gastrointestinal tract involved, by enteroendocrine cells, the secretion of several gut hormones such as cholecystokinin (CCK) and peptide YY (PYY) but also glucagon-like peptide 1 (GLP-1), gastric inhibitory peptide (GIP) and 5-hydroxytryptamine (5-HT), which transmitted signals to the brain via the gut-brain axis. Trichothecenes 23-37 peptide YY Homo sapiens 188-191 30243968-6 2018 The indirect action of trichothecenes in the gastrointestinal tract involved, by enteroendocrine cells, the secretion of several gut hormones such as cholecystokinin (CCK) and peptide YY (PYY) but also glucagon-like peptide 1 (GLP-1), gastric inhibitory peptide (GIP) and 5-hydroxytryptamine (5-HT), which transmitted signals to the brain via the gut-brain axis. Trichothecenes 23-37 glucagon Homo sapiens 202-225 30243968-6 2018 The indirect action of trichothecenes in the gastrointestinal tract involved, by enteroendocrine cells, the secretion of several gut hormones such as cholecystokinin (CCK) and peptide YY (PYY) but also glucagon-like peptide 1 (GLP-1), gastric inhibitory peptide (GIP) and 5-hydroxytryptamine (5-HT), which transmitted signals to the brain via the gut-brain axis. Trichothecenes 23-37 glucagon Homo sapiens 227-232 30243968-6 2018 The indirect action of trichothecenes in the gastrointestinal tract involved, by enteroendocrine cells, the secretion of several gut hormones such as cholecystokinin (CCK) and peptide YY (PYY) but also glucagon-like peptide 1 (GLP-1), gastric inhibitory peptide (GIP) and 5-hydroxytryptamine (5-HT), which transmitted signals to the brain via the gut-brain axis. Trichothecenes 23-37 gastric inhibitory polypeptide Homo sapiens 235-261 30243968-6 2018 The indirect action of trichothecenes in the gastrointestinal tract involved, by enteroendocrine cells, the secretion of several gut hormones such as cholecystokinin (CCK) and peptide YY (PYY) but also glucagon-like peptide 1 (GLP-1), gastric inhibitory peptide (GIP) and 5-hydroxytryptamine (5-HT), which transmitted signals to the brain via the gut-brain axis. Trichothecenes 23-37 gastric inhibitory polypeptide Homo sapiens 263-266 29909314-4 2018 The goal of this study is to relate plasma 5-HT and SP to anorectic responses induced by type A trichothecenes T-2 toxin (T-2), HT-2 toxin (HT-2), diacetoxyscirpenol (DAS) and neosolaniol (NEO). Trichothecenes 96-110 tachykinin precursor 1 Homo sapiens 52-54 29578706-1 2018 An artificial metabolic route to an unnatural trichothecene was designed by taking advantage of the broad substrate specificities of the T-2 toxin biosynthetic enzymes of Fusarium sporotrichioides. Trichothecenes 46-59 solute carrier family 25 member 5 Homo sapiens 137-140 28130091-1 2017 T-2 toxin, a major compound of trichothecenes, induces cell apoptosis and growth hormone (GH) deficiency and causes considerable growth retardation in animals and human cells. Trichothecenes 31-45 solute carrier family 25 member 5 Homo sapiens 0-3 29580086-8 2018 Due to the effect of both trichothecenes, expression of the glutathione synthetase gene (GSS) was significantly lower than in the control at hours 24 and 48. Trichothecenes 26-40 glutathione synthetase Gallus gallus 60-82 29354057-1 2017 T-2 toxin is one of the type A trichothecenes produced mainly by the Fusarium genus. Trichothecenes 31-45 solute carrier family 25 member 5 Homo sapiens 0-3 28666375-3 2017 In this study, we hypothesized that anorexia induced by type A trichothecenes, including T-2 toxin (T-2), HT-2 toxin (HT-2), diacetoxyscirpenol (DAS), and neosolaniol (NEO), in mice corresponds to the changes in the gut satiety hormones peptide YY3-36 (PYY3-36) and glucose-dependent insulinotropic polypeptide (GIP) in plasma. Trichothecenes 63-77 gastric inhibitory polypeptide Mus musculus 266-310 28666375-3 2017 In this study, we hypothesized that anorexia induced by type A trichothecenes, including T-2 toxin (T-2), HT-2 toxin (HT-2), diacetoxyscirpenol (DAS), and neosolaniol (NEO), in mice corresponds to the changes in the gut satiety hormones peptide YY3-36 (PYY3-36) and glucose-dependent insulinotropic polypeptide (GIP) in plasma. Trichothecenes 63-77 gastric inhibitory polypeptide Mus musculus 312-315 28964791-0 2017 Gut satiety hormones cholecystokinin and glucagon-like Peptide-17-36 amide mediate anorexia induction by trichothecenes T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol. Trichothecenes 105-119 cholecystokinin Homo sapiens 21-36 28964791-3 2017 Type B trichothecenes have been previously demonstrated to elicit robust anorectic responses, and this response has been directly linked to secretion of the gut satiety hormones cholecystokinin (CCK) and glucagon-like peptide-17-36 amide (GLP-1). Trichothecenes 7-21 cholecystokinin Homo sapiens 178-193 28964791-3 2017 Type B trichothecenes have been previously demonstrated to elicit robust anorectic responses, and this response has been directly linked to secretion of the gut satiety hormones cholecystokinin (CCK) and glucagon-like peptide-17-36 amide (GLP-1). Trichothecenes 7-21 cholecystokinin Homo sapiens 195-198 28964791-3 2017 Type B trichothecenes have been previously demonstrated to elicit robust anorectic responses, and this response has been directly linked to secretion of the gut satiety hormones cholecystokinin (CCK) and glucagon-like peptide-17-36 amide (GLP-1). Trichothecenes 7-21 glucagon like peptide 1 receptor Homo sapiens 239-244 28964791-5 2017 The purpose of this study was to relate type A trichothecenes T-2, HT-2, DAS and NEO-induced anorectic response to changes plasma concentrations of CCK and GLP-1. Trichothecenes 47-61 cholecystokinin Homo sapiens 148-151 28964791-5 2017 The purpose of this study was to relate type A trichothecenes T-2, HT-2, DAS and NEO-induced anorectic response to changes plasma concentrations of CCK and GLP-1. Trichothecenes 47-61 glucagon like peptide 1 receptor Homo sapiens 156-161 28862744-5 2017 The effect of deletion of the yeast HDA1 orthologue was also observed in Fusarium asiaticum from the Fusarium graminearum species complex; the HDF2 deletion mutant produced increased levels of nivalenol-type trichothecenes. Trichothecenes 208-222 histone deacetylase HDA1 Saccharomyces cerevisiae S288C 36-40 28862744-10 2017 In addition, production of Fusarium trichothecenes, previously reported to be unaffected by HDA1 deletion, was significantly upregulated in another Fusarium species. Trichothecenes 36-50 histone deacetylase HDA1 Saccharomyces cerevisiae S288C 92-96 28229023-9 2017 Tri12 sequences from a range of geographically diverse fungal strains comprising 22 Fusarium species were stored in the ToxGen database, which covers descriptive and up-to-date annotations such as indication on Tri genotype and chemotype of the strains, chemical diversity, information on trichothecene-inducing host, substrate or media, geographical locality, and most recent taxonomic affiliations. Trichothecenes 289-302 tRNA-Ile (anticodon AAT) 9-1 Homo sapiens 0-3 26085520-1 2016 T-2 toxin is one of the mycotoxins, a group of type A trichothecenes produced by several fungal genera including Fusarium species, which may lead to the decrease of testosterone secretion in primary Leydig cells derived from mouse testis. Trichothecenes 54-68 brachyury 2 Mus musculus 0-3 27573873-0 2016 The inhibition of cell proliferation and induction of apoptosis in pancreatic ductal adenocarcinoma cells by verrucarin A, a macrocyclic trichothecene, is associated with the inhibition of Akt/NF-kB/mTOR prosurvival signaling. Trichothecenes 137-150 AKT serine/threonine kinase 1 Homo sapiens 189-192 27495375-3 2016 Further we have illustrated how trichodermin resistance protein (60S ribosomal protein L3) helps to overcome the deleterious effects of trichothecene compounds like trichodermin. Trichothecenes 136-149 ribosomal protein L3 Homo sapiens 69-89 25895426-1 2015 T-2 toxin is one form of trichothecenes, which contaminate crops and feedstuff commonly, and has a wide variety of toxic effects in human and animals, but little is known regarding its role on reproductive function and puberty development. Trichothecenes 25-39 solute carrier family 25 member 5 Homo sapiens 0-3 26141394-1 2015 Chronic exposure to trichothecenes is known to disturb insulin-like growth factor 1 and signaling of insulin and leptin hormones and causes considerable growth retardation in animals. Trichothecenes 20-34 insulin-like growth factor 1 Rattus norvegicus 55-83 26141394-4 2015 Our results showed that trichothecenes suppressed the synthesis of growth hormone 1 (Gh1) and inhibited the eukaryotic transcription and translation initiation by suppressing aminoacyl-tRNA synthetases transcription, inducing eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and reducing eukaryotic translation initiation factor 5 a. Trichothecenes 24-38 growth hormone 1 Rattus norvegicus 67-83 26141394-4 2015 Our results showed that trichothecenes suppressed the synthesis of growth hormone 1 (Gh1) and inhibited the eukaryotic transcription and translation initiation by suppressing aminoacyl-tRNA synthetases transcription, inducing eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and reducing eukaryotic translation initiation factor 5 a. Trichothecenes 24-38 growth hormone 1 Rattus norvegicus 85-88 26141394-4 2015 Our results showed that trichothecenes suppressed the synthesis of growth hormone 1 (Gh1) and inhibited the eukaryotic transcription and translation initiation by suppressing aminoacyl-tRNA synthetases transcription, inducing eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and reducing eukaryotic translation initiation factor 5 a. Trichothecenes 24-38 eukaryotic translation initiation factor 2-alpha kinase 2 Rattus norvegicus 226-283 26141394-4 2015 Our results showed that trichothecenes suppressed the synthesis of growth hormone 1 (Gh1) and inhibited the eukaryotic transcription and translation initiation by suppressing aminoacyl-tRNA synthetases transcription, inducing eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and reducing eukaryotic translation initiation factor 5 a. Trichothecenes 24-38 eukaryotic translation initiation factor 2-alpha kinase 2 Rattus norvegicus 285-292 26141394-4 2015 Our results showed that trichothecenes suppressed the synthesis of growth hormone 1 (Gh1) and inhibited the eukaryotic transcription and translation initiation by suppressing aminoacyl-tRNA synthetases transcription, inducing eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and reducing eukaryotic translation initiation factor 5 a. Trichothecenes 24-38 eukaryotic translation initiation factor 5A Rattus norvegicus 307-351 26141394-7 2015 However, use of RNAi to interfere with hemopoietic cell kinase (Hck) and EIF2AK2 transcriptions or use of chemical inhibitors of MAPK, p38, Ras, and JNK partially reversed the reduction of Gh1 levels induced by trichothecenes. Trichothecenes 211-225 HCK proto-oncogene, Src family tyrosine kinase Rattus norvegicus 39-62 26141394-7 2015 However, use of RNAi to interfere with hemopoietic cell kinase (Hck) and EIF2AK2 transcriptions or use of chemical inhibitors of MAPK, p38, Ras, and JNK partially reversed the reduction of Gh1 levels induced by trichothecenes. Trichothecenes 211-225 growth hormone 1 Rattus norvegicus 189-192 26141394-8 2015 It indicated that the activation of MAPKs, Hck, and EIF2AK2 were important for trichothecene-induced growth hormone suppression. Trichothecenes 79-92 HCK proto-oncogene, Src family tyrosine kinase Rattus norvegicus 43-46 26141394-8 2015 It indicated that the activation of MAPKs, Hck, and EIF2AK2 were important for trichothecene-induced growth hormone suppression. Trichothecenes 79-92 eukaryotic translation initiation factor 2-alpha kinase 2 Rattus norvegicus 52-59 26141394-8 2015 It indicated that the activation of MAPKs, Hck, and EIF2AK2 were important for trichothecene-induced growth hormone suppression. Trichothecenes 79-92 gonadotropin releasing hormone receptor Rattus norvegicus 101-115 26321427-1 2015 A rapid method for the liquid chromatography-tandem mass spectrometric determination of type A and B trichothecenes and their major metabolites in chicken meat, pork, chicken liver, and swine liver was developed. Trichothecenes 101-115 myosin, heavy chain 9, non-muscle Gallus gallus 88-100 26057253-5 2015 Here we show that one of the resistant lines identified, trichothecene resistant 1 (trr1) contains a T-DNA insertion upstream of two nonspecific lipid transfer protein (nsLTP) genes, AtLTP4.4 and AtLTP4.5. Trichothecenes 57-70 lipid transfer protein 4 Arabidopsis thaliana 183-189 26057253-5 2015 Here we show that one of the resistant lines identified, trichothecene resistant 1 (trr1) contains a T-DNA insertion upstream of two nonspecific lipid transfer protein (nsLTP) genes, AtLTP4.4 and AtLTP4.5. Trichothecenes 57-70 lipid transfer protein 4 Arabidopsis thaliana 196-202 25269780-1 2014 T-2 toxin, a major compound of trichothecenes, inhibits protein synthesis and induces inflammation and cell apoptosis through the activation of MAPK pathway. Trichothecenes 31-45 brachyury 2 Mus musculus 0-3 25784098-1 2015 BACKGROUND: T-2 mycotoxin belongs to the Trichothecene family and has damaging effects on the immune system. Trichothecenes 41-54 brachyury 2 Mus musculus 12-15 25521494-1 2014 Double-stranded RNA (dsRNA)-activated protein kinase (PKR) is a critical upstream mediator of the ribotoxic stress response (RSR) to the trichothecene deoxynivalenol (DON) and other translational inhibitors. Trichothecenes 137-150 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 54-57 25269780-3 2014 However, whether there is any crosstalk between JNK and JAK/STAT pathways in trichothecene toxicity has not been studied. Trichothecenes 77-90 mitogen-activated protein kinase 8 Mus musculus 48-51 24269698-3 2014 Previously, we have shown that water-damaged building associated trichothecene mycotoxins, including roridin A, trigger IL-1beta and IL-18 secretion in human macrophages. Trichothecenes 65-78 interleukin 1 beta Homo sapiens 120-128 25083910-8 2014 Trichothecenes were not produced at detectable levels, and expression of trichothecene biosynthesis genes were significantly reduced in the elp3 deletion mutant. Trichothecenes 0-14 Elongator subunit ELP3 Saccharomyces cerevisiae S288C 140-144 25083910-8 2014 Trichothecenes were not produced at detectable levels, and expression of trichothecene biosynthesis genes were significantly reduced in the elp3 deletion mutant. Trichothecenes 73-86 Elongator subunit ELP3 Saccharomyces cerevisiae S288C 140-144 25184434-1 2014 T-2 toxin, one of the type A trichothecenes, presents a potential hazard to human and animal health. Trichothecenes 29-43 solute carrier family 25 member 5 Homo sapiens 0-3 24894432-2 2014 Among the trichothecenes, T-2 toxin and deoxynivalenol (DON) cause the most concern due to their wide distribution and highly toxic nature. Trichothecenes 10-24 solute carrier family 25 member 5 Homo sapiens 26-29 24355099-1 2014 T-2 toxin is one of the most toxic Fusarium-derived trichothecenes found on cereals and constitutes a widespread contaminant of agricultural commodities as well as commercial foods. Trichothecenes 52-66 solute carrier family 25 member 5 Homo sapiens 0-3 24269698-3 2014 Previously, we have shown that water-damaged building associated trichothecene mycotoxins, including roridin A, trigger IL-1beta and IL-18 secretion in human macrophages. Trichothecenes 65-78 interleukin 18 Homo sapiens 133-138 24269698-5 2014 Here, we show that the trichothecene-induced IL-1beta secretion is dependent on NLRP3 inflammasome in human primary macrophages. Trichothecenes 23-36 interleukin 1 beta Homo sapiens 45-53 24269698-5 2014 Here, we show that the trichothecene-induced IL-1beta secretion is dependent on NLRP3 inflammasome in human primary macrophages. Trichothecenes 23-36 NLR family pyrin domain containing 3 Homo sapiens 80-85 24269698-6 2014 Pharmacological inhibition and small interfering RNA approach showed that the trichothecene-induced NLRP3 inflammasome activation is mediated through ATP-gated P2X7 receptor. Trichothecenes 78-91 NLR family pyrin domain containing 3 Homo sapiens 100-105 24269698-6 2014 Pharmacological inhibition and small interfering RNA approach showed that the trichothecene-induced NLRP3 inflammasome activation is mediated through ATP-gated P2X7 receptor. Trichothecenes 78-91 purinergic receptor P2X 7 Homo sapiens 160-173 24269698-7 2014 Moreover, we show that trichothecene-triggered NLRP3 inflammasome activation is dependent on Src tyrosine kinase activity. Trichothecenes 23-36 NLR family pyrin domain containing 3 Homo sapiens 47-52 22982764-8 2012 Whereas HMGR and CYP19 were down-regulated, CYP1A1 and CYP21 were up-regulated by all three trichothecenes. Trichothecenes 92-106 cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus 44-50 23869809-4 2013 The double bond between C-9-C-10 and the 12,13-epoxide ring are essential structural features for trichothecene toxicity. Trichothecenes 98-111 complement C9 Homo sapiens 24-27 23869809-6 2013 A hydroxyl group at C-3 enhances trichothecene toxicity, while this activity decreases gradually when C-3 is substituted with either hydrogen or an acetoxy group. Trichothecenes 33-46 complement C3 Homo sapiens 20-23 23869809-8 2013 The toxicity for type B trichothecenes decreases if the substituent at C-4 is changed from acetoxy to hydroxyl or hydrogen at C-4 position. Trichothecenes 24-38 complement C4A (Rodgers blood group) Homo sapiens 71-74 23869809-8 2013 The toxicity for type B trichothecenes decreases if the substituent at C-4 is changed from acetoxy to hydroxyl or hydrogen at C-4 position. Trichothecenes 24-38 complement C4A (Rodgers blood group) Homo sapiens 126-129 23869809-10 2013 Trichothecenes toxicity increases when a macrocyclic ring exists between the C-4 and C-15. Trichothecenes 0-14 complement C4A (Rodgers blood group) Homo sapiens 77-80 23869809-11 2013 At C-8 position, an oxygenated substitution at C-8 is essential for trichothecene toxicity, indicating a decrease in the toxicity if substituent change from isovaleryloxy through hydrogen to the hydroxyl group. Trichothecenes 68-81 homeobox C8 Homo sapiens 3-6 23869809-11 2013 At C-8 position, an oxygenated substitution at C-8 is essential for trichothecene toxicity, indicating a decrease in the toxicity if substituent change from isovaleryloxy through hydrogen to the hydroxyl group. Trichothecenes 68-81 homeobox C8 Homo sapiens 47-50 23869809-12 2013 The presence of a second epoxy ring at C-7-C-8 reduces the toxicity, whereas epoxidation at C-9-C-10 of some macrocyclic trichothecenes increases the activity. Trichothecenes 121-135 complement C9 Homo sapiens 92-95 22960706-1 2012 T-2 toxin is one of the most toxic among several trichothecenes involved in both human and animal poisoning cases. Trichothecenes 49-63 solute carrier family 25 member 5 Homo sapiens 0-3 22903826-0 2012 Anorexia induction by the trichothecene deoxynivalenol (vomitoxin) is mediated by the release of the gut satiety hormone peptide YY. Trichothecenes 26-39 peptide YY Homo sapiens 121-131 23022514-1 2012 The Type B trichothecene deoxynivalenol (DON), a ribotoxic mycotoxin known to contaminate cereal-based foods, induces ribosomal RNA (rRNA) cleavage in the macrophage via p38-directed activation of caspases. Trichothecenes 11-24 mitogen-activated protein kinase 14 Mus musculus 170-173 23022514-1 2012 The Type B trichothecene deoxynivalenol (DON), a ribotoxic mycotoxin known to contaminate cereal-based foods, induces ribosomal RNA (rRNA) cleavage in the macrophage via p38-directed activation of caspases. Trichothecenes 11-24 caspase 8 Mus musculus 197-205 22982764-8 2012 Whereas HMGR and CYP19 were down-regulated, CYP1A1 and CYP21 were up-regulated by all three trichothecenes. Trichothecenes 92-106 cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus 55-60 22454431-5 2012 Interestingly, the time when the mRNA levels of STAT1 and STAT3 were significantly upregulated was at 12 h, which was much later than the time when mitogen-activated protein kinase was activated, indicating that STATs might be the downstream targets of the trichothecenes. Trichothecenes 257-271 signal transducer and activator of transcription 1 Mus musculus 212-217 22454431-4 2012 AG490 and Stattic, the specific inhibitors of JAK/STAT pathway, blocked the STAT1 and STAT3 tyrosine phosphorylation and decreased the gene expressions of proinflammatory cytokines induced by trichothecenes. Trichothecenes 192-206 signal transducer and activator of transcription 1 Mus musculus 76-81 22454431-4 2012 AG490 and Stattic, the specific inhibitors of JAK/STAT pathway, blocked the STAT1 and STAT3 tyrosine phosphorylation and decreased the gene expressions of proinflammatory cytokines induced by trichothecenes. Trichothecenes 192-206 signal transducer and activator of transcription 3 Mus musculus 86-91 22454431-5 2012 Interestingly, the time when the mRNA levels of STAT1 and STAT3 were significantly upregulated was at 12 h, which was much later than the time when mitogen-activated protein kinase was activated, indicating that STATs might be the downstream targets of the trichothecenes. Trichothecenes 257-271 signal transducer and activator of transcription 1 Mus musculus 48-53 22454431-5 2012 Interestingly, the time when the mRNA levels of STAT1 and STAT3 were significantly upregulated was at 12 h, which was much later than the time when mitogen-activated protein kinase was activated, indicating that STATs might be the downstream targets of the trichothecenes. Trichothecenes 257-271 signal transducer and activator of transcription 3 Mus musculus 58-63 23606127-1 2012 T-2 toxin, a toxic member of the group A trichothecenes, is produced by various Fusarium species that can potentially affect human health. Trichothecenes 41-55 solute carrier family 25 member 5 Homo sapiens 0-3 22069698-7 2011 This result implies that these hydrogen-bonding interactions could play an important role in the biological function of T-2 toxin and posits towards a possible interaction for the trichothecene class of toxins and the ribosome. Trichothecenes 180-193 solute carrier family 25 member 5 Homo sapiens 120-123 22245378-1 2012 T-2 toxin is the type-A trichothecene and a common contaminant of food and cereals, produced by Fusarium species. Trichothecenes 24-37 brachyury 2 Mus musculus 0-3 21745144-1 2011 T-2 toxin, a highly toxic member of the type-A trichothecenes, is produced by various Fusarium moulds that can potentially affect human health. Trichothecenes 47-61 solute carrier family 25 member 5 Homo sapiens 0-3 20181660-1 2010 The trichothecene deoxynivalenol (DON) binds to eukaryotic ribosomes and triggers p38-driven proinflammatory gene expression in the macrophage-a response that is dependent on both double-stranded RNA-activated protein kinase (PKR) and hematopoietic cell kinase (Hck). Trichothecenes 4-17 mitogen-activated protein kinase 14 Homo sapiens 82-85 21398559-3 2011 In vitro, T-2 toxin, a trichothecenes mycotoxin, has been demonstrated to inhibit aggrecan synthesis and promote aggrecanase and pro-inflammatory cytokine production in cultured chondrocytes. Trichothecenes 23-37 brachyury 2 Rattus norvegicus 10-13 20181660-1 2010 The trichothecene deoxynivalenol (DON) binds to eukaryotic ribosomes and triggers p38-driven proinflammatory gene expression in the macrophage-a response that is dependent on both double-stranded RNA-activated protein kinase (PKR) and hematopoietic cell kinase (Hck). Trichothecenes 4-17 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 226-229 20181660-1 2010 The trichothecene deoxynivalenol (DON) binds to eukaryotic ribosomes and triggers p38-driven proinflammatory gene expression in the macrophage-a response that is dependent on both double-stranded RNA-activated protein kinase (PKR) and hematopoietic cell kinase (Hck). Trichothecenes 4-17 HCK proto-oncogene, Src family tyrosine kinase Homo sapiens 262-265 19625342-0 2009 Induction of suppressors of cytokine signaling by the trichothecene deoxynivalenol in the mouse. Trichothecenes 54-67 cytokine inducible SH2-containing protein Mus musculus 13-46 20150440-1 2010 We have characterized cell death in THP-1 cells after exposure to heat-treated spores from satratoxin G-producing Stachybotrys chartarum isolate IBT 9631, atranone-producing S. chartarum isolate IBT 9634, and sterigmatocystin-producing Aspergillus versicolor isolate IBT 3781, as well as the trichothecenes T-2 and satratoxin G. Spores induced cell death within 3-6 h, with Stachybotrys appearing most potent. Trichothecenes 292-306 GLI family zinc finger 2 Homo sapiens 36-41 19635492-6 2010 Moreover, the analysis of the cytokine pattern showed that IL-12 and IL-10 expressions induced by LPS exposure were suppressed by both trichothecenes in a dose-dependent fashion. Trichothecenes 135-149 interleukin 10 Mus musculus 69-74 18502741-1 2008 Trichothecene mycotoxins rapidly induce p38-mediated gene expression and apoptosis in mononuclear phagocytes via a process known as the ribotoxic stress response. Trichothecenes 0-13 mitogen-activated protein kinase 14 Mus musculus 40-43 19526462-1 2009 T-2 toxin is one of the most potent trichothecenes, and on exposure causes severe human and animal diseases. Trichothecenes 36-50 solute carrier family 25 member 5 Homo sapiens 0-3 18602807-1 2009 Consumption of the trichothecene mycotoxin deoxynivalenol (DON) induces interleukin-6 (IL-6)-dependent IgA nephropathy (IgAN) in mice. Trichothecenes 19-32 interleukin 6 Mus musculus 72-85 18602807-1 2009 Consumption of the trichothecene mycotoxin deoxynivalenol (DON) induces interleukin-6 (IL-6)-dependent IgA nephropathy (IgAN) in mice. Trichothecenes 19-32 interleukin 6 Mus musculus 87-91 19428930-2 2009 Among the trichothecenes, T-2 toxin is one of the most potent mycotoxins and poses a potential health risk in human nutrition. Trichothecenes 10-24 solute carrier family 25 member 5 Homo sapiens 26-29 18776660-0 2008 4-O-acetylation and 3-O-acetylation of trichothecenes by trichothecene 15-O-acetyltransferase encoded by Fusarium Tri3. Trichothecenes 39-53 CAS1 domain containing 1 Homo sapiens 74-93 18776660-6 2008 The significance of the trace trichothecene 3-O-acetyltransferase activity detected in rTRI3 is discussed in relation to the evolution of the trichothecene gene cluster. Trichothecenes 30-43 CAS1 domain containing 1 Homo sapiens 46-65 18791285-1 2008 BACKGROUND: T-2 toxin is a mycotoxin of type A trichothecenes produced by several fungal genera such as Fusarium species. Trichothecenes 47-61 brachyury 2 Mus musculus 12-15 23604982-1 2009 Trichothecene cytotoxicity of type A (T-2 toxin and HT-2 toxin), type B (deoxynivalenol, DON, and nivalenol, NIV), and type D (satratoxins G and H) compounds was determined comparatively by using eight permanent human cell lines (Hep-G2, A549, CaCo-2, HEp-2, A204, U937, RPMI 8226, and Jurkat). Trichothecenes 0-13 solute carrier family 25 member 5 Homo sapiens 38-41 19336499-1 2009 The trichothecene mycotoxin deoxynivalenol (DON) induces systemic expression of the interleukin-6 (IL-6) and other proinflammatory cytokines in the mouse. Trichothecenes 4-17 interleukin 6 Mus musculus 84-97 19336499-1 2009 The trichothecene mycotoxin deoxynivalenol (DON) induces systemic expression of the interleukin-6 (IL-6) and other proinflammatory cytokines in the mouse. Trichothecenes 4-17 interleukin 6 Mus musculus 99-103 19336499-11 2009 Three other trichothecenes (satratoxin G, roridin, T-2 toxin) and the ribosome inhibitory protein ricin were also found to induce GRP78 degradation suggesting that other translation inhibitors might evoke ER stress. Trichothecenes 12-26 heat shock protein 5 Mus musculus 130-135 18502741-2 2008 We hypothesized that the trichothecene deoxynivalenol (DON) induces interaction of p38 with the ribosome. Trichothecenes 25-38 mitogen-activated protein kinase 14 Mus musculus 83-86 18220574-1 2008 Among the naturally-occurring trichothecenes found in food and feed, T-2 toxin is the most potent and toxic mycotoxin. Trichothecenes 30-44 solute carrier family 25 member 5 Homo sapiens 69-72 18069941-0 2008 AtNFXL1, an Arabidopsis homologue of the human transcription factor NF-X1, functions as a negative regulator of the trichothecene phytotoxin-induced defense response. Trichothecenes 116-129 NF-X-like 1 Arabidopsis thaliana 0-7 18069941-0 2008 AtNFXL1, an Arabidopsis homologue of the human transcription factor NF-X1, functions as a negative regulator of the trichothecene phytotoxin-induced defense response. Trichothecenes 116-129 nuclear transcription factor, X-box binding 1 Homo sapiens 68-73 18069941-2 2008 In Arabidopsis, expression of AtNFXL1, a homologue of the putative human transcription repressor NF-X1, was significantly induced by application of type A trichothecenes, such as T-2 toxin. Trichothecenes 155-169 NF-X-like 1 Arabidopsis thaliana 30-37 18069941-2 2008 In Arabidopsis, expression of AtNFXL1, a homologue of the putative human transcription repressor NF-X1, was significantly induced by application of type A trichothecenes, such as T-2 toxin. Trichothecenes 155-169 nuclear transcription factor, X-box binding 1 Homo sapiens 97-102 18069941-3 2008 An atnfxl1 mutant growing on medium lacking trichothecenes showed no phenotype, whereas a hypersensitivity phenotype was observed in T-2 toxin-treated atnfxl1 mutant plants. Trichothecenes 44-58 NF-X-like 1 Arabidopsis thaliana 3-10 18069941-10 2008 Taken together, these results indicate that AtNFXL1 plays an important role in the trichothecene response, as well as the general defense response in Arabidopsis. Trichothecenes 83-96 NF-X-like 1 Arabidopsis thaliana 44-51 18220574-3 2008 Some metabolites of this trichothecene are equally toxic or slightly more toxic than T-2 itself, and therefore, the metabolic fate of T-2 toxin has been of great concern. Trichothecenes 25-38 solute carrier family 25 member 5 Homo sapiens 134-137 19704430-0 2008 The AtNFXL1 gene functions as a signaling component of the type A trichothecene-dependent response. Trichothecenes 66-79 NF-X-like 1 Arabidopsis thaliana 4-11 19704430-5 2008 The atnfxl1 mutant exhibited hypersensitivity phenotype to T-2 toxin but not to type B deoxynivalenol (DON) in comparison with wild type when Arabidopsis thaliana grew on agar medium containing trichothecenes. Trichothecenes 194-208 NF-X-like 1 Arabidopsis thaliana 4-11 19704430-7 2008 Growth defect by another type A trichothecene diacetoxyscirpenol (DAS), was weakly enhanced in the atnfxl1 mutant. Trichothecenes 32-45 NF-X-like 1 Arabidopsis thaliana 99-106 19704430-11 2008 Consequently, the AtNFXL1 gene functions as a signaling component of the type A trichothecene-dependent response in Arabidopsis. Trichothecenes 80-93 NF-X-like 1 Arabidopsis thaliana 18-25 19704430-12 2008 In addition, the C8 position of trichothecenes might be closely related to the function of AtNFXL1 gene. Trichothecenes 32-46 NF-X-like 1 Arabidopsis thaliana 91-98 16020192-7 2005 Heightened mRNA expression of these immunomodulators combined with comparatively depressed MIP-2 and tumor necrosis factor (TNF)-a protein expression suggests that the action of macrocyclic trichothecenes sequestered in 58-17 spores is involved. Trichothecenes 190-204 tumor necrosis factor Mus musculus 101-130 16517116-6 2006 The exposure to trichothecenes during dendritic cell maturation upon addition of LPS or TNF-alpha markedly inhibited the up-regulation of maturation markers such as CD-86, HLA-DR and CCR7. Trichothecenes 16-30 interferon regulatory factor 6 Homo sapiens 81-84 16517116-6 2006 The exposure to trichothecenes during dendritic cell maturation upon addition of LPS or TNF-alpha markedly inhibited the up-regulation of maturation markers such as CD-86, HLA-DR and CCR7. Trichothecenes 16-30 tumor necrosis factor Homo sapiens 88-97 16517116-6 2006 The exposure to trichothecenes during dendritic cell maturation upon addition of LPS or TNF-alpha markedly inhibited the up-regulation of maturation markers such as CD-86, HLA-DR and CCR7. Trichothecenes 16-30 C-C motif chemokine receptor 7 Homo sapiens 183-187 16517116-7 2006 Features of LPS or TNF-alpha -mediated maturation of dendritic cells, such as IL-10 and IL-12 secretions and endocytosis, were also impaired in response to trichothecenes treatment. Trichothecenes 156-170 interferon regulatory factor 6 Homo sapiens 12-15 16517116-7 2006 Features of LPS or TNF-alpha -mediated maturation of dendritic cells, such as IL-10 and IL-12 secretions and endocytosis, were also impaired in response to trichothecenes treatment. Trichothecenes 156-170 tumor necrosis factor Homo sapiens 19-28 16517116-7 2006 Features of LPS or TNF-alpha -mediated maturation of dendritic cells, such as IL-10 and IL-12 secretions and endocytosis, were also impaired in response to trichothecenes treatment. Trichothecenes 156-170 interleukin 10 Homo sapiens 78-83 16307838-1 2006 T-2 toxin is one of the mycotoxins, a group of type A trichothecenes produced by several fungal genera including Fusarium species. Trichothecenes 54-68 solute carrier family 25 member 5 Homo sapiens 0-3 15908172-0 2005 Myelotoxicity of trichothecenes and apoptosis: an in vitro study on human cord blood CD34+ hematopoietic progenitor. Trichothecenes 17-31 CD34 molecule Homo sapiens 85-89 17618029-2 2007 T-2 toxin, as the most toxic trichothecene, has been implicated as the causative agent in a variety of animal diseases and is associated with some human diseases. Trichothecenes 29-42 solute carrier family 25 member 5 Homo sapiens 0-3 16673938-7 2006 Moreover, infiltration by trichothecenes caused rapid and prolonged activation of two mitogen-activated protein kinases and induced expression of both PR-1 and PDF1.2 genes. Trichothecenes 26-40 pathogenesis-related protein 1 Arabidopsis thaliana 151-155 16673938-7 2006 Moreover, infiltration by trichothecenes caused rapid and prolonged activation of two mitogen-activated protein kinases and induced expression of both PR-1 and PDF1.2 genes. Trichothecenes 26-40 protodermal factor 1 Arabidopsis thaliana 160-164 14597125-0 2003 Potentiation of trichothecene-induced leukocyte cytotoxicity and apoptosis by TNF-alpha and Fas activation. Trichothecenes 16-29 tumor necrosis factor Mus musculus 78-87 15772366-0 2005 Ribotoxic stress response to the trichothecene deoxynivalenol in the macrophage involves the SRC family kinase Hck. Trichothecenes 33-46 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 93-96 15772366-0 2005 Ribotoxic stress response to the trichothecene deoxynivalenol in the macrophage involves the SRC family kinase Hck. Trichothecenes 33-46 HCK proto-oncogene, Src family tyrosine kinase Homo sapiens 111-114 15778012-1 2005 Ingestion of the trichothecene mycotoxin deoxynivalenol (DON) induces serum IgA elevation and kidney mesangial IgA deposition in a manner that mimics the early stages of IgA nephropathy (IgAN), the most common human glomerulonephritis. Trichothecenes 17-30 CD79a molecule Homo sapiens 76-79 15778012-1 2005 Ingestion of the trichothecene mycotoxin deoxynivalenol (DON) induces serum IgA elevation and kidney mesangial IgA deposition in a manner that mimics the early stages of IgA nephropathy (IgAN), the most common human glomerulonephritis. Trichothecenes 17-30 CD79a molecule Homo sapiens 111-114 15778012-1 2005 Ingestion of the trichothecene mycotoxin deoxynivalenol (DON) induces serum IgA elevation and kidney mesangial IgA deposition in a manner that mimics the early stages of IgA nephropathy (IgAN), the most common human glomerulonephritis. Trichothecenes 17-30 IGAN1 Homo sapiens 170-185 15778012-1 2005 Ingestion of the trichothecene mycotoxin deoxynivalenol (DON) induces serum IgA elevation and kidney mesangial IgA deposition in a manner that mimics the early stages of IgA nephropathy (IgAN), the most common human glomerulonephritis. Trichothecenes 17-30 IGAN1 Homo sapiens 187-191 17134394-0 2004 Toxin-dependent utilization of engineered ribosomal protein L3 limits trichothecene resistance in transgenic plants. Trichothecenes 70-83 ribosomal 60S subunit protein L3 Saccharomyces cerevisiae S288C 42-62 17134394-5 2004 Using yeast as a model system, we have identified several mutations in the gene encoding ribosomal protein L3 (Rpl3), which confer semi-dominant resistance to trichothecenes. Trichothecenes 159-173 ribosomal 60S subunit protein L3 Saccharomyces cerevisiae S288C 89-109 17134394-5 2004 Using yeast as a model system, we have identified several mutations in the gene encoding ribosomal protein L3 (Rpl3), which confer semi-dominant resistance to trichothecenes. Trichothecenes 159-173 ribosomal 60S subunit protein L3 Saccharomyces cerevisiae S288C 111-115 17134394-9 2004 This toxin-dependent utilization of the resistance-conferring Rpl3 protein could seriously limit efforts to utilize the identified target alterations in transgenic crops to increase trichothecene tolerance and Fusarium resistance. Trichothecenes 182-195 ribosomal 60S subunit protein L3 Saccharomyces cerevisiae S288C 62-66 14690764-1 2003 The trichothecene mycotoxin deoxynivalenol (DON) induces IgA hyperelevation and mesangial IgA deposition in mice that mimics the early stages of human IgA nephropathy (IgAN). Trichothecenes 4-17 IGAN1 Homo sapiens 151-166 14690764-1 2003 The trichothecene mycotoxin deoxynivalenol (DON) induces IgA hyperelevation and mesangial IgA deposition in mice that mimics the early stages of human IgA nephropathy (IgAN). Trichothecenes 4-17 IGAN1 Homo sapiens 168-172 14597125-2 2003 Trichothecene-induced leukocyte apoptosis can be augmented by bacterial lipopolysaccharide (LPS) but the mechanisms involved in this potentiating effect are not completely understood. Trichothecenes 0-13 toll-like receptor 4 Mus musculus 92-95 14597125-3 2003 The objective of this study was to test the hypothesis that the trichothecene deoxynivalenol (DON, vomitoxin) can interact with LPS directly and other mediators or agonists associated with immune/inflammatory responses to induce apoptosis in primary murine leukocyte cultures. Trichothecenes 64-77 toll-like receptor 4 Mus musculus 128-131 14597125-9 2003 Taken together, these data demonstrate that LPS and its downstream mediators can interact with trichothecenes to modulate proliferative, cytotoxic and apoptotic outcomes in leukocytes in a tissue-specific manner. Trichothecenes 95-109 toll-like receptor 4 Mus musculus 44-47 14514436-0 2003 Relationship of trichothecene structure to COX-2 induction in the macrophage: selective action of type B (8-keto) trichothecenes. Trichothecenes 16-29 prostaglandin-endoperoxide synthase 2 Mus musculus 43-48 14514436-1 2003 The trichothecene mycotoxin deoxynivalenol (DON, vomitoxin), when at partially cytotoxic concentrations, induces cyclooxygenase-2 (COX-2) expression by promoting transcriptional activity and mRNA stability via mitogen-activated protein kinase (MAPK) signaling pathways. Trichothecenes 4-17 prostaglandin-endoperoxide synthase 2 Mus musculus 113-129 14514436-1 2003 The trichothecene mycotoxin deoxynivalenol (DON, vomitoxin), when at partially cytotoxic concentrations, induces cyclooxygenase-2 (COX-2) expression by promoting transcriptional activity and mRNA stability via mitogen-activated protein kinase (MAPK) signaling pathways. Trichothecenes 4-17 prostaglandin-endoperoxide synthase 2 Mus musculus 131-136 14514436-1 2003 The trichothecene mycotoxin deoxynivalenol (DON, vomitoxin), when at partially cytotoxic concentrations, induces cyclooxygenase-2 (COX-2) expression by promoting transcriptional activity and mRNA stability via mitogen-activated protein kinase (MAPK) signaling pathways. Trichothecenes 4-17 mitogen-activated protein kinase 1 Mus musculus 244-248 14514436-2 2003 The purpose of this study was to test the hypothesis that trichothecenes differentially affect COX-2 gene expression and that these effects were related to MAPK activation. Trichothecenes 58-72 prostaglandin-endoperoxide synthase 2 Mus musculus 95-100 14514436-2 2003 The purpose of this study was to test the hypothesis that trichothecenes differentially affect COX-2 gene expression and that these effects were related to MAPK activation. Trichothecenes 58-72 mitogen-activated protein kinase 1 Mus musculus 156-160 14514436-3 2003 Representative members of the three major trichothecene families (A, B, and D) were compared for their capacity to induce COX-2 in the RAW 264.7 murine macrophage cell line. Trichothecenes 42-55 prostaglandin-endoperoxide synthase 2 Mus musculus 122-127 14514436-6 2003 Type B but not Type A or D toxins at concentrations up to the MTT IC50 enhanced luciferase activities, indicating preferential COX-2 transcriptional activation and mRNA stabilization by this trichothecene subset. Trichothecenes 191-204 prostaglandin-endoperoxide synthase 2 Mus musculus 127-132 14514436-7 2003 At their respective IC20s, Type B trichothecenes also significantly activated the three major MAPK families, whereas Type A and D did not. Trichothecenes 34-48 mitogen-activated protein kinase 1 Mus musculus 94-98 14514436-10 2003 Taken together, Type B trichothecenes selectively enhanced transcription and stabilization of the COX-2 gene, and this was mediated by the ERK 1/2 and p38 signaling pathways. Trichothecenes 23-37 prostaglandin-endoperoxide synthase 2 Mus musculus 98-103 14514436-10 2003 Taken together, Type B trichothecenes selectively enhanced transcription and stabilization of the COX-2 gene, and this was mediated by the ERK 1/2 and p38 signaling pathways. Trichothecenes 23-37 mitogen-activated protein kinase 3 Mus musculus 139-146 14514436-10 2003 Taken together, Type B trichothecenes selectively enhanced transcription and stabilization of the COX-2 gene, and this was mediated by the ERK 1/2 and p38 signaling pathways. Trichothecenes 23-37 mitogen-activated protein kinase 14 Mus musculus 151-154 14514436-11 2003 Selective action on COX-2 might contribute to unique pathologic manifestations associated with Type B trichothecene-mediated immunotoxicity. Trichothecenes 102-115 prostaglandin-endoperoxide synthase 2 Mus musculus 20-25 12604170-0 2003 Up-regulation of macrophage inflammatory protein-2 and complement 3A receptor by the trichothecenes deoxynivalenol and satratoxin G. Trichothecenes 85-99 chemokine (C-X-C motif) ligand 2 Mus musculus 17-50 12773753-3 2003 The purpose of this research was to test the hypothesis that double-stranded, RNA-activated protein kinase R (PKR) is a critical upstream mediator of the ribotoxic stress response induced by the trichothecene deoxynivalenol (DON) and other translational inhibitors. Trichothecenes 195-208 eukaryotic translation initiation factor 2-alpha kinase 2 Mus musculus 110-113 12749813-5 2003 Deoxynivalenol and T-2 toxin are examples of trichothecenes that are detectable as natural and unavoidable contaminants of certain agricultural commodities as well as commercial foods. Trichothecenes 45-59 solute carrier family 25 member 5 Homo sapiens 19-22 12604170-0 2003 Up-regulation of macrophage inflammatory protein-2 and complement 3A receptor by the trichothecenes deoxynivalenol and satratoxin G. Trichothecenes 85-99 complement component 3a receptor 1 Mus musculus 55-77 12604170-11 2003 Up-regulation of MIP-2 and C3aR are consistent with previous reports of trichothecene-induced inflammatory gene up-regulation and suggest that the specific genes affected may depend on trichothecene structures. Trichothecenes 72-85 chemokine (C-X-C motif) ligand 2 Mus musculus 17-22 12604170-11 2003 Up-regulation of MIP-2 and C3aR are consistent with previous reports of trichothecene-induced inflammatory gene up-regulation and suggest that the specific genes affected may depend on trichothecene structures. Trichothecenes 72-85 complement component 3a receptor 1 Mus musculus 27-31 12604170-11 2003 Up-regulation of MIP-2 and C3aR are consistent with previous reports of trichothecene-induced inflammatory gene up-regulation and suggest that the specific genes affected may depend on trichothecene structures. Trichothecenes 185-198 chemokine (C-X-C motif) ligand 2 Mus musculus 17-22 12604170-11 2003 Up-regulation of MIP-2 and C3aR are consistent with previous reports of trichothecene-induced inflammatory gene up-regulation and suggest that the specific genes affected may depend on trichothecene structures. Trichothecenes 185-198 complement component 3a receptor 1 Mus musculus 27-31 12554543-3 2003 In LPS-stimulated cultures, TNF-alpha supernatant concentrations were significantly increased in the presence of 2.5, 2.5, and 1 ng/ml of SG, SH, and RA, respectively, whereas IL-6 concentrations were not affected by the same concentrations these macrocyclic trichothecenes. Trichothecenes 259-273 tumor necrosis factor Mus musculus 28-37 12554543-7 2003 These results indicate that low concentrations of macrocyclic trichothecenes superinduce expression of TNF-alpha, whereas higher concentrations of these toxins are cytotoxic and concurrently reduce cytokine production. Trichothecenes 62-76 tumor necrosis factor Mus musculus 103-112 12674145-2 2003 8-alpha-Acetoxyverrol (4), the first open chain example of the trichothecenes with oxygenation at C-8, was isolated from cultures of Aphanocladium spectabile. Trichothecenes 63-77 homeobox C8 Homo sapiens 98-101 11962696-10 2002 GC-MS after derivatization with TRI-SIL TBT was suitable for the structural characterization of trichothecenes and their degradation products. Trichothecenes 96-110 STIL centriolar assembly protein Homo sapiens 36-39 12478589-3 2002 FsTri101 encodes a trichothecene 3-O-acetyltransferase that functions in trichothecene biosynthesis. Trichothecenes 19-32 acetyltransferase Saccharomyces cerevisiae S288C 37-54 11577712-2 2001 The rank order of the potency of trichothecene mycotoxins to induce internucleosomal DNA fragmentation was found to be T-2, satratoxin G, roridin A >> diacetoxyscirpenol > baccharin B-5 >> nivalenol, deoxynivalenol, 3-acetyldeoxynivalenol, fusarenon-X, baccharin B-4=vehicle control. Trichothecenes 33-46 solute carrier family 25 member 5 Homo sapiens 119-122 10485289-8 1999 PDR5, a transporter of the ABC superfamily, which is known to mediate trichothecene resistance in yeast, increased calonectrin accumulation in TRI12/TRI3 yeast strains but not in TRI3 strains. Trichothecenes 70-83 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 0-4 10960733-0 2000 Transgenic expression of the TRI101 or PDR5 gene increases resistance of tobacco to the phytotoxic effects of the trichothecene 4,15-diacetoxyscirpenol. Trichothecenes 114-127 ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C 39-43 10662601-9 2000 Elevation of AP-1 activity may contribute to cytokine dysregulation and immunotoxic effects associated with exposure to trichothecene mycotoxins such as VT. Trichothecenes 120-133 jun proto-oncogene Mus musculus 13-17 10764628-2 2000 The purpose of this study was to relate cytotoxic and apoptotic capacities of satratoxins and other trichothecenes to the activation of three groups of mitogen-activated protein kinases (MAPKs) (extracellular signal-regulated protein kinase (ERK), p38 MAPK, and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK)). Trichothecenes 100-114 mitogen-activated protein kinase 1 Homo sapiens 195-240 10764628-6 2000 Assessment of MAPK activation using Western blot analysis revealed that trichothecenes activated not only SAPK/JNK and p38 MAPK but also ERK. Trichothecenes 72-86 mitogen-activated protein kinase 14 Homo sapiens 119-122 10764628-6 2000 Assessment of MAPK activation using Western blot analysis revealed that trichothecenes activated not only SAPK/JNK and p38 MAPK but also ERK. Trichothecenes 72-86 mitogen-activated protein kinase 1 Homo sapiens 137-140 10494915-0 1999 Effects of satratoxins and other macrocyclic trichothecenes on IL-2 production and viability of EL-4 thymoma cells. Trichothecenes 45-59 interleukin 2 Mus musculus 63-67 10494915-9 1999 The results indicate that, at low concentrations, macrocyclic trichothecenes as a group could superinduce IL-2 production even while partially decreasing cell viability, whereas higher concentrations suppressed cytokine production and were markedly cytotoxic. Trichothecenes 62-76 interleukin 2 Mus musculus 106-110 8560498-0 1995 Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T-cells. Trichothecenes 11-24 CD4 antigen Mus musculus 87-90 10318810-3 1999 We have found that selected trichothecenes strongly activate JNK/p38 kinases and induce rapid apoptosis in Jurkat T cells. Trichothecenes 28-42 mitogen-activated protein kinase 8 Homo sapiens 61-64 10318810-3 1999 We have found that selected trichothecenes strongly activate JNK/p38 kinases and induce rapid apoptosis in Jurkat T cells. Trichothecenes 28-42 mitogen-activated protein kinase 14 Homo sapiens 65-68 10318810-4 1999 Although the ability of individual trichothecenes to inhibit protein synthesis and activate JNK/p38 kinases are dissociable, both effects contribute to the induction of apoptosis. Trichothecenes 35-49 mitogen-activated protein kinase 8 Homo sapiens 92-95 10318810-4 1999 Although the ability of individual trichothecenes to inhibit protein synthesis and activate JNK/p38 kinases are dissociable, both effects contribute to the induction of apoptosis. Trichothecenes 35-49 mitogen-activated protein kinase 14 Homo sapiens 96-99 10318810-5 1999 Among trichothecenes that strongly activate JNK/p38 kinases, induction of apoptosis increases linearly with inhibition of protein synthesis. Trichothecenes 6-20 mitogen-activated protein kinase 8 Homo sapiens 44-47 10318810-5 1999 Among trichothecenes that strongly activate JNK/p38 kinases, induction of apoptosis increases linearly with inhibition of protein synthesis. Trichothecenes 6-20 mitogen-activated protein kinase 14 Homo sapiens 48-51 10318810-6 1999 Among trichothecenes that strongly inhibit protein synthesis, induction of apoptosis increases linearly with activation of JNK/p38 kinases. Trichothecenes 6-20 mitogen-activated protein kinase 8 Homo sapiens 123-126 10318810-6 1999 Among trichothecenes that strongly inhibit protein synthesis, induction of apoptosis increases linearly with activation of JNK/p38 kinases. Trichothecenes 6-20 mitogen-activated protein kinase 14 Homo sapiens 127-130 10318810-7 1999 Trichothecenes that inhibit protein synthesis without activating JNK/p38 kinases inhibit the function (i.e. activation of JNK/p38 kinases and induction of apoptosis) of apoptotic trichothecenes and anisomycin. Trichothecenes 0-14 mitogen-activated protein kinase 8 Homo sapiens 122-125 10318810-7 1999 Trichothecenes that inhibit protein synthesis without activating JNK/p38 kinases inhibit the function (i.e. activation of JNK/p38 kinases and induction of apoptosis) of apoptotic trichothecenes and anisomycin. Trichothecenes 0-14 mitogen-activated protein kinase 14 Homo sapiens 126-129 10318810-7 1999 Trichothecenes that inhibit protein synthesis without activating JNK/p38 kinases inhibit the function (i.e. activation of JNK/p38 kinases and induction of apoptosis) of apoptotic trichothecenes and anisomycin. Trichothecenes 179-193 mitogen-activated protein kinase 14 Homo sapiens 69-72 10318810-7 1999 Trichothecenes that inhibit protein synthesis without activating JNK/p38 kinases inhibit the function (i.e. activation of JNK/p38 kinases and induction of apoptosis) of apoptotic trichothecenes and anisomycin. Trichothecenes 179-193 mitogen-activated protein kinase 8 Homo sapiens 122-125 10318810-7 1999 Trichothecenes that inhibit protein synthesis without activating JNK/p38 kinases inhibit the function (i.e. activation of JNK/p38 kinases and induction of apoptosis) of apoptotic trichothecenes and anisomycin. Trichothecenes 179-193 mitogen-activated protein kinase 14 Homo sapiens 126-129 8887449-1 1996 The trichothecene mycotoxin vomitoxin (VT, deoxynivalenol) superinduces the gene expression of IL-2 and several other cytokines in both cellular and murine models. Trichothecenes 4-17 interleukin 2 Mus musculus 95-99 9662416-0 1998 Modulation of IL-1beta, IL-6 and TNF-alpha secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line. Trichothecenes 80-93 interleukin 1 beta Mus musculus 14-22 9662416-0 1998 Modulation of IL-1beta, IL-6 and TNF-alpha secretion and mRNA expression by the trichothecene vomitoxin in the RAW 264.7 murine macrophage cell line. Trichothecenes 80-93 tumor necrosis factor Mus musculus 33-42 8560498-4 1995 At day 2, all trichothecenes were found to have inhibited production of IL-2, IL-4, and IL-5. Trichothecenes 14-28 interleukin 2 Mus musculus 72-76 8560498-4 1995 At day 2, all trichothecenes were found to have inhibited production of IL-2, IL-4, and IL-5. Trichothecenes 14-28 interleukin 4 Mus musculus 78-82 8560498-4 1995 At day 2, all trichothecenes were found to have inhibited production of IL-2, IL-4, and IL-5. Trichothecenes 14-28 interleukin 5 Mus musculus 88-92 8560498-10 1995 Taken together, the results suggest that trichothecenes as a group can either inhibit or superinduce both IL secretion and mRNA levels in CD4+ T-cells. Trichothecenes 41-55 CD4 antigen Mus musculus 138-141 7657054-1 1995 Ingestion of the trichothecene vomitoxin (VT) by mice induces effects that mimic the common human glomerulonephritis, IgA nephropathy (IgAN). Trichothecenes 17-30 IGAN1 Homo sapiens 118-133 7657054-1 1995 Ingestion of the trichothecene vomitoxin (VT) by mice induces effects that mimic the common human glomerulonephritis, IgA nephropathy (IgAN). Trichothecenes 17-30 IGAN1 Homo sapiens 135-139 32795851-1 2021 Deoxynivalenol (DON) and T-2 toxin are major trichothecenes contaminated in cereals, which might bring harmful effects to humans. Trichothecenes 45-59 solute carrier family 25 member 5 Homo sapiens 25-28 2200582-0 1990 Metabolic effects of trichothecene T-2 toxin. Trichothecenes 21-34 solute carrier family 25 member 5 Homo sapiens 35-38 2312012-5 1990 Uptake of alpha-[3H]T-2 toxin was also inhibited by verrucarin A, roridin A and deoxynivalenol, and the inhibition followed a trichothecene structure-activity rank similar to that established for protein synthesis inhibition and in vivo toxicity. Trichothecenes 126-139 brachyury 2 Mus musculus 20-23 8473003-9 1993 The observed effects of T-2 toxin on brain monoamines and the resulting neurochemical imbalance may account for the physiological manifestation of trichothecene intoxication. Trichothecenes 147-160 brachyury 2 Rattus norvegicus 24-27 8404460-0 1993 Metabolism and pharmacokinetics of T-2 toxin and related trichothecenes. Trichothecenes 57-71 solute carrier family 25 member 5 Homo sapiens 35-38 2145206-1 1990 Recent investigations indicate that dietary exposure to the trichothecene vomitoxin increases total and antigen-specific serum immunoglobulin A (IgA) and glomerular IgA accumulation in mice. Trichothecenes 60-73 immunoglobulin heavy constant alpha Mus musculus 127-149 21417259-2 2011 Among the naturally occurring trichothecenes in food and feed, T-2 toxin is a cytotoxic fungal secondary metabolite produced by various species of Fusarium. Trichothecenes 30-44 solute carrier family 25 member 5 Homo sapiens 63-66