PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15521060-5	2004	The results showed that chronic nicotine and smoking treatment differentially changed the levels of TH protein in VTA and SNC and DA D1 receptor levels in Nac and CPu.	nac	155-158	tyrosine hydroxylase	Rattus norvegicus	100-102
15533326-5	2004	The DAMGO-induced increase of food intake following injection into the CeA was decreased by bilateral injection of NTX (13.2 and 26.5 nmol) into the NAc at 2- and 4-h postinjections (P<0.05).	nac	149-152	carcinoembryonic antigen gene family 4	Rattus norvegicus	71-74
15533326-7	2004	These results suggest that a bi-directional mu-opioid-opioid signalling pathway exists between the CeA and the NAc, which influences feeding.	nac	111-114	carcinoembryonic antigen gene family 4	Rattus norvegicus	99-102
15598141-0	2004	Intra-BLA or intra-NAc infusions of the dopamine D3 receptor partial agonist, BP 897, block intra-NAc amphetamine conditioned activity.	nac	19-22	dopamine receptor D3	Rattus norvegicus	40-60
15322689-6	2004	(2) When antioxidant NAC (500 mmol/L) was added into the medium, the level of IkappaBalpha phosphorylation showed no significant changes during hypoxia.	nac	21-24	NFKB inhibitor alpha	Rattus norvegicus	78-90
15616876-3	2004	But NAC followed by surgery may improve survival in patients with stage Ib2 compared with surgery alone; and in patients with stage Ib2 to IIB compared with RT alone.	nac	4-7	mitogen-activated protein kinase 8 interacting protein 2	Homo sapiens	72-75
14756560-9	2004	hDAT-alpha-synuclein protein-protein interactions occurred through residues 58-107 (NAC domain) of the alpha-synuclein variants and residues 598-620 of the carboxy-terminal tail of hDAT, in both trypsinized and nontrypsinized cells.	nac	84-87	solute carrier family 6 member 3	Homo sapiens	0-4
15202996-7	2004	These likely reflect the misregulation of other NAC-domain mRNAs, including NAC1, At5g07680, and At5g61430, for which miR164-directed cleavage products were detected.	nac	48-51	NAC domain containing protein 1	Arabidopsis thaliana	76-80
15202996-7	2004	These likely reflect the misregulation of other NAC-domain mRNAs, including NAC1, At5g07680, and At5g61430, for which miR164-directed cleavage products were detected.	nac	48-51	MIR164a	Arabidopsis thaliana	118-124
15202996-9	2004	They also show that proper miR164 dosage or localization is required for separation of adjacent embryonic, vegetative, and floral organs, thus implicating miR164 as a common regulatory component of the molecular circuitry that controls the separation of different developing organs and thereby exposes a posttranscriptional layer of NAC-domain gene regulation during plant development.	nac	333-336	MIR164a	Arabidopsis thaliana	27-33
15202996-9	2004	They also show that proper miR164 dosage or localization is required for separation of adjacent embryonic, vegetative, and floral organs, thus implicating miR164 as a common regulatory component of the molecular circuitry that controls the separation of different developing organs and thereby exposes a posttranscriptional layer of NAC-domain gene regulation during plant development.	nac	333-336	MIR164a	Arabidopsis thaliana	155-161
14978478-9	2004	Serum starved human lens epithelial cells stimulated with different growth factors including EGF, b-FGF, PDGF, TGF-beta, and LPA demonstrated increased production of ROS, a response which was blocked by inhibitors of NADPH oxidase, such as DPI and the antioxidant-N-acetyl cysteine (NAC).	nac	283-286	fibroblast growth factor 2	Homo sapiens	98-103
15341629-0	2004	A dehydration-induced NAC protein, RD26, is involved in a novel ABA-dependent stress-signaling pathway.	nac	22-25	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	35-39
15341629-1	2004	Arabidopsis thaliana RD26 cDNA, isolated from dehydrated plants, encodes a NAC protein.	nac	75-78	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	21-25
14756560-9	2004	hDAT-alpha-synuclein protein-protein interactions occurred through residues 58-107 (NAC domain) of the alpha-synuclein variants and residues 598-620 of the carboxy-terminal tail of hDAT, in both trypsinized and nontrypsinized cells.	nac	84-87	synuclein alpha	Homo sapiens	5-20
14756560-9	2004	hDAT-alpha-synuclein protein-protein interactions occurred through residues 58-107 (NAC domain) of the alpha-synuclein variants and residues 598-620 of the carboxy-terminal tail of hDAT, in both trypsinized and nontrypsinized cells.	nac	84-87	synuclein alpha	Homo sapiens	103-118
14663845-1	2004	In this paper, we introduced a novel storage architecture "Unified Storage Network", which merges NAC(Network Attached Channel) and SAN(Storage Area Network), and provides the file I/O services as NAS devices and provides the block I/O services as SAN.	nac	98-101	N-alpha-acetyltransferase 50, NatE catalytic subunit	Homo sapiens	248-251
14684901-0	2004	Preliminary crystallographic analysis of the NAC domain of ANAC, a member of the plant-specific NAC transcription factor family.	nac	45-48	nascent polypeptide associated complex subunit alpha 2	Homo sapiens	59-63
14684901-1	2004	The NAC domain (residues 1-168) of ANAC, encoded by the abscisic acid-responsive NAC gene from Arabidopsis thaliana, was recombinantly produced in Escherichia coli and crystallized in hanging drops.	nac	4-7	nascent polypeptide associated complex subunit alpha 2	Homo sapiens	35-39
12847091-6	2003	Enzymatic analysis of the transferase reaction products showed that D4ST-1 far more efficiently transferred sulfate to GalNAc residues in -IdoUA-Gal-NAc-IdoUA-than in -GlcUA-GalNAc-GlcUA-sequences.	nac	122-125	carbohydrate sulfotransferase 14	Homo sapiens	68-74
14625141-2	2003	Here we show that BDNF in the ventral tegmental area-nucleus accumbens (VTA-NAc) pathway is also involved in the development of a depression-like phenotype.	nac	76-79	brain-derived neurotrophic factor	Rattus norvegicus	18-22
14625141-3	2003	METHODS: Brain-derived neurotrophic factor signaling in the VTA-NAc pathway was altered in two complementary ways.	nac	64-67	brain-derived neurotrophic factor	Rattus norvegicus	9-42
14625141-8	2003	Intra-NAc injections of TrkB.T1 resulted in and almost fivefold longer latency to immobility relative to TrkB.FL and control animals, an antidepressant-like effect.	nac	6-9	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	24-28
14625141-10	2003	CONCLUSIONS: These data suggest that BDNF action in the VTA-NAc pathway might be related to development of a depression-like phenotype.	nac	60-63	brain-derived neurotrophic factor	Rattus norvegicus	37-41
14625141-11	2003	This interpretation is intriguing in that it suggests a role for BDNF in the VTA-NAc that is opposite of the proposed role for BDNF in the hippocampus.	nac	81-84	brain-derived neurotrophic factor	Rattus norvegicus	65-69
14981992-5	2003	Four (31%) out of 13 patients with CCND1 amplification responded to NAC whereas the response rate in the non-amplified group was 79% (p = 0.011).	nac	68-71	cyclin D1	Homo sapiens	35-40
14981992-8	2003	CONCLUSION: Detection of CCND1 amplification using FISH may be a useful marker of sensitivity to NAC and chemoradiotherapy for HNSCC.	nac	97-100	cyclin D1	Homo sapiens	25-30
15029955-1	2003	The NAC domain was originally characterized from consensus sequences from petunia NAM and from Arabidopsis ATAF1, ATAF2, and CUC2.	nac	4-7	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	107-112
15029955-1	2003	The NAC domain was originally characterized from consensus sequences from petunia NAM and from Arabidopsis ATAF1, ATAF2, and CUC2.	nac	4-7	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	114-119
15029955-1	2003	The NAC domain was originally characterized from consensus sequences from petunia NAM and from Arabidopsis ATAF1, ATAF2, and CUC2.	nac	4-7	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	125-129
12847091-8	2003	Structural analysis of the oligosaccharides, which were isolated after chondroitinase AC-I digestion of the 35S-labeled transferase reaction products, revealed for the first time that D4ST-1, as compared with C4ST-1 and C4ST-2, most efficiently utilized GalNAc residues located not only in the sequence -IdoUA-GalNAc-IdoUA- but also in -GlcUA-Gal-NAc-IdoUA- and -IdoUA-GalNAc-GlcUA-.	nac	257-260	carbohydrate sulfotransferase 14	Homo sapiens	184-190
12626393-0	2003	Purification and cDNA cloning of UDP-GlcNAc:GlcNAcbeta1-3Galbeta1-4Glc(NAc)-R [GlcNAc to Gal]beta1,6N-acetylglucosaminyltransferase from rat small intestine: a major carrier of dIGnT activity in rat small intestine.	nac	40-43	glucosaminyl (N-acetyl) transferase 1	Rattus norvegicus	93-131
12756215-8	2003	Our results support the direct involvement of Mrp2 in the hepatobiliary excretion of several conjugated metabolites of APAP, including APAP-GSH and APAP-NAC, and provide relevant information on processes that may be involved with both their hepatic basolateral transport and renal elimination.	nac	153-156	ATP binding cassette subfamily C member 2	Rattus norvegicus	46-50
14532998-1	2003	The aims of this study were to examine the overexpression of COX-2 protein and its relationship to apoptosis in cervical carcinoma patients treated with neoadjuvant chemo-therapy (NAC), and to assess the potential role of COX-2 as a predictor of the response to NAC in a series of patients with cervical carcinoma.	nac	180-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
14532998-1	2003	The aims of this study were to examine the overexpression of COX-2 protein and its relationship to apoptosis in cervical carcinoma patients treated with neoadjuvant chemo-therapy (NAC), and to assess the potential role of COX-2 as a predictor of the response to NAC in a series of patients with cervical carcinoma.	nac	262-265	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66
14532998-14	2003	Our findings suggest that COX-2 protein expression could be used as a predictor of chemoresistance and that assessment of the COX-2 status could be useful to identify cervical cancer patients who may benefit from NAC.	nac	213-216	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131
12775719-2	2003	By immunoprecipitation we detected specific binding of this CARD6-encoding protein to Nod1 (CARD4), Cardiak (Rip2/Rick), NAC (NALP1/DEFCAP/CARD7), and TUCAN (CARD8/Cardinal/NDPP/Dakar), caspase recruitment domain (CARD)-containing proteins implicated in NF-kappa B and caspase-1 activation but not to other CARD family proteins.	nac	121-124	caspase recruitment domain family member 6	Homo sapiens	60-65
12646039-3	2003	RHA2a interacted with one of the plant-specific NAC [NAM ("no apical meristem"), ATAF1/2, CUC2 ("cup-shaped cotyledons 2")] transcription factors, here named ANAC (abscisic acid-responsive NAC).	nac	159-162	RING-H2 finger A2A	Arabidopsis thaliana	0-5
12646039-3	2003	RHA2a interacted with one of the plant-specific NAC [NAM ("no apical meristem"), ATAF1/2, CUC2 ("cup-shaped cotyledons 2")] transcription factors, here named ANAC (abscisic acid-responsive NAC).	nac	159-162	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	53-56
12646039-0	2003	Interactions between plant RING-H2 and plant-specific NAC (NAM/ATAF1/2/CUC2) proteins: RING-H2 molecular specificity and cellular localization.	nac	54-57	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	59-62
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	adrenoceptor alpha 1D	Homo sapiens	45-53
12646039-0	2003	Interactions between plant RING-H2 and plant-specific NAC (NAM/ATAF1/2/CUC2) proteins: RING-H2 molecular specificity and cellular localization.	nac	54-57	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	63-70
12646039-0	2003	Interactions between plant RING-H2 and plant-specific NAC (NAM/ATAF1/2/CUC2) proteins: RING-H2 molecular specificity and cellular localization.	nac	54-57	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	71-75
12646039-3	2003	RHA2a interacted with one of the plant-specific NAC [NAM ("no apical meristem"), ATAF1/2, CUC2 ("cup-shaped cotyledons 2")] transcription factors, here named ANAC (abscisic acid-responsive NAC).	nac	48-51	RING-H2 finger A2A	Arabidopsis thaliana	0-5
12646039-3	2003	RHA2a interacted with one of the plant-specific NAC [NAM ("no apical meristem"), ATAF1/2, CUC2 ("cup-shaped cotyledons 2")] transcription factors, here named ANAC (abscisic acid-responsive NAC).	nac	48-51	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	53-56
12669402-1	2003	We report a 65-year-old man with advanced gastric cancer that showed a remarkable response to treatment with a new combination of paclitaxel (TXL) and low-dose 5-fluorouracil and cisplatin (FP) as neoadjuvant chemotherapy (NAC).	nac	223-226	thioredoxin like 1	Homo sapiens	142-145
12669402-6	2003	After three courses of NAC, the CEA and AFP levels decreased to 245.0 ng/ml and 754.0 U/ml, respectively.	nac	23-26	CEA cell adhesion molecule 3	Homo sapiens	32-35
12669402-6	2003	After three courses of NAC, the CEA and AFP levels decreased to 245.0 ng/ml and 754.0 U/ml, respectively.	nac	23-26	alpha fetoprotein	Homo sapiens	40-43
12669402-13	2003	TXL + low-dose FP as NAC may be one of the new tactics against advanced gastric cancer.	nac	21-24	thioredoxin like 1	Homo sapiens	0-3
12830711-10	2003	Simultaneously, it showed decrease of ROS, less activity of JNK and lower expression of cleaved Caspase-3 in 10 mumol.L-1 Rg1 and 2.5 mmol.L-1 NAC pretreated groups compared with groups treated with MPP+ only.	nac	143-146	immunoglobulin kappa variable 3-15	Homo sapiens	118-131
12162463-5	2002	The scavenging of UV-generated H2O2 by N-acety-L-cyteine (NAC, a general antioxidant) or catalase (a specific H2O2 inhibitor) inhibited UV-induced activation of JNKs, p38 kinase, Akt and p70(S6k), while it did not show any inhibitory effects on Erks activation.	nac	58-61	thymoma viral proto-oncogene 1	Mus musculus	179-182
12162463-5	2002	The scavenging of UV-generated H2O2 by N-acety-L-cyteine (NAC, a general antioxidant) or catalase (a specific H2O2 inhibitor) inhibited UV-induced activation of JNKs, p38 kinase, Akt and p70(S6k), while it did not show any inhibitory effects on Erks activation.	nac	58-61	interleukin 2 receptor, beta chain	Mus musculus	187-190
12162463-5	2002	The scavenging of UV-generated H2O2 by N-acety-L-cyteine (NAC, a general antioxidant) or catalase (a specific H2O2 inhibitor) inhibited UV-induced activation of JNKs, p38 kinase, Akt and p70(S6k), while it did not show any inhibitory effects on Erks activation.	nac	58-61	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	191-194
12675500-7	2003	A beta-structure was detected by CD spectroscopy in the 1 mM NAC(1-13) at pH 2.2 immediately after preparation.	nac	61-64	amyloid beta precursor protein	Homo sapiens	0-6
12175016-1	2002	The petunia NAM and ArabidopsisATAF1 and CUC2 genes define the conserved NAC domain.	nac	73-76	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	41-45
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	61-68
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	adrenoceptor alpha 1D	Homo sapiens	80-88
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	97-104
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	112-119
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	112-119
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	adrenoceptor alpha 1D	Homo sapiens	80-88
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	165-172
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	165-172
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	112-119
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	adrenoceptor alpha 1D	Homo sapiens	80-88
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	112-119
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	adrenoceptor alpha 1D	Homo sapiens	80-88
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	112-119
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	165-172
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	112-119
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	adrenoceptor alpha 1D	Homo sapiens	80-88
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	112-119
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	adrenoceptor alpha 1D	Homo sapiens	80-88
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	165-172
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	165-172
11856306-3	2002	Their structures have been determined as Fuc(alpha1-3)GalNAc(beta1-4)[ +/- Fuc (alpha1-3)]GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4) Glc-PA, Fuc(alpha1-3)GalNAc(beta1-4)[Fuc(alpha1-3)]GlcNAc(beta1-4) GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA, and Fuc(alpha1-3) GalNAc(beta1-4)[ +/- Fuc(alpha1-2) +/- Fuc(alpha1-2)Fuc(alpha1-3)]Glc NAc(beta1-3)GlcNAc(beta1-3)GalNAc(beta1-4)Glc-PA.	nac	57-60	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	112-119
11699836-3	2001	Of the bile salts/acids studied, incorporation of 100 mg of deoxycholic acid (DCA), sodium cholate (NaC), or sodium deoxycholate (NaDC) with insulin (10 U/Kg) showed that suppositories containing NaDC produced the highest area under the curve (AUC) and relative hypoglycemia (RH) of 290 +/- 83 mg%h and 28% +/- 8.1%, respectively.	nac	100-103	insulin	Canis lupus familiaris	141-148
12220944-4	2002	NAC 100 and 200 microM, but not 20 microM, was found to attenuate the kinetic parameters of initial phase of fMLP-stimulated PMNs oxidative burst.	nac	0-3	formyl peptide receptor 1	Homo sapiens	109-113
12220944-5	2002	NAC at the concentration of 100 and 200 microM decreased the rate, maximum and integrated value of PMNs response to fMLP.	nac	0-3	formyl peptide receptor 1	Homo sapiens	116-120
12220944-6	2002	The integrated value of PMA-induced PMNs and fMLP-induced whole blood LDCL response was also decreased by 100 and 200 microM NAC.	nac	125-128	formyl peptide receptor 1	Homo sapiens	45-49
12220944-11	2002	Both PMA- and fMLP-activated PMNs oxidized extracellular NAC.	nac	57-60	formyl peptide receptor 1	Homo sapiens	14-18
11710691-7	2001	Multivariate analysis confirmed the strong post-NAC effects of histologic type, AI/V, and MDR1 expression for RFS, and recurrence, age, and Ki-67 expression for OS.	nac	48-51	ATP binding cassette subfamily B member 1	Homo sapiens	90-94
11699836-8	2001	When the effect of sodium taurocholate (NaTC) and sodium taurodeoxycholate (NaTDC) was studied, it was found that an insulin suppository containing 100 mg of either NaTC or NaTDC produced an RH equivalent to that produced previouslY with a mixture of NaDC (100 mg) and NaC (50 mg).	nac	269-272	insulin	Canis lupus familiaris	117-124
11507090-9	2001	The scavenging of UV-generated H(2)O(2) by N-acety-l-cyteine (NAC, a general antioxidant) or catalase (a specific H(2)O(2) inhibitor) inhibited Akt phosphorylation at Ser-473 and Thr-308, whereas the pretreatment of cells with sodium formate (an .OH radical scavenger) or superoxide dismutase (an O(-.2) radical scavenger) did not show any inhibitory effects.	nac	62-65	thymoma viral proto-oncogene 1	Mus musculus	144-147
11519039-8	2001	Antioxidants such as NAC and PDTC inhibited doxorubicin-induced uPA mRNA accumulation.	nac	21-24	plasminogen activator, urokinase	Homo sapiens	64-67
10651775-6	2000	Only CGRP (50 micromol/L) induced significantly more histamine release from both NAC and CVA patients compared with control subjects (P = 0.038 and 0.045, respectively).	nac	81-84	calcitonin related polypeptide alpha	Homo sapiens	5-9
11498280-5	2001	NAC and PDTC blocked the activation of ASK1 and MG-induced apoptosis completely.	nac	0-3	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	39-43
11409648-7	2001	In contrast, p38 MAPK activation was inhibited by DPI and ascorbic acid concentration-dependently, but by NAC only at high concentration.	nac	106-109	mitogen activated protein kinase 14	Rattus norvegicus	13-16
11746666-2	2001	alpha-Synuclein protein and a fragment of it, called NAC, have been found in association with pathological lesions of neurodegenerative diseases.	nac	53-56	synuclein alpha	Bos taurus	0-15
11494520-17	2001	The mean amounts and percentages of cost for NAC were 39,473 points and 16.1% for the rad.	nac	45-48	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	86-89
11494520-21	2001	The mean amounts of cost for NAC including examination costs and nursing costs for chemotherapy were 130,196 points and 54.5% for the rad.	nac	29-32	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	134-137
11091212-1	2000	The anti-CD33 monoclonal antibody linked to NAc-gamma calicheamicin gemtuzumab ozogamicin (CMA-676) was used to treat a patient with Philadelphia/bcr-abl-positive acute myeloid leukaemia.	nac	44-47	CD33 molecule	Homo sapiens	9-13
10828862-4	2000	Although T cell proliferative and cytokine (IFN-gamma and IL-4) responses to alloantigen stimulation and Con A were significantly reduced in post-G-CSF NAC, they were restored by the removal of non-T cells from post-G-CSF NAC.	nac	152-155	interferon gamma	Homo sapiens	44-53
10828862-4	2000	Although T cell proliferative and cytokine (IFN-gamma and IL-4) responses to alloantigen stimulation and Con A were significantly reduced in post-G-CSF NAC, they were restored by the removal of non-T cells from post-G-CSF NAC.	nac	152-155	interleukin 4	Homo sapiens	58-62
10828862-4	2000	Although T cell proliferative and cytokine (IFN-gamma and IL-4) responses to alloantigen stimulation and Con A were significantly reduced in post-G-CSF NAC, they were restored by the removal of non-T cells from post-G-CSF NAC.	nac	152-155	colony stimulating factor 3	Homo sapiens	146-151
10593934-2	1999	In Dictyostelium, Skp1 is modified by a linear pentasaccharide, Galalpha1-6Galalpha1-Fucalpha1-2Galbeta1-3Glc NAc, attached to a hydroxyproline (HyPro) residue at position 143.	nac	110-113	S-phase kinase associated protein 1	Homo sapiens	18-22
10660065-1	2000	Genes that encode products containing a NAC domain, such as NO APICAL MERISTEM (NAM) in petunia, CUP-SHAPED COTYLEDON2 (CUC2) and NAP in Arabidopsis thaliana, have crucial functions in plant development.	nac	40-43	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	60-78
10660065-1	2000	Genes that encode products containing a NAC domain, such as NO APICAL MERISTEM (NAM) in petunia, CUP-SHAPED COTYLEDON2 (CUC2) and NAP in Arabidopsis thaliana, have crucial functions in plant development.	nac	40-43	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	80-83
10660065-1	2000	Genes that encode products containing a NAC domain, such as NO APICAL MERISTEM (NAM) in petunia, CUP-SHAPED COTYLEDON2 (CUC2) and NAP in Arabidopsis thaliana, have crucial functions in plant development.	nac	40-43	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	97-118
10660065-1	2000	Genes that encode products containing a NAC domain, such as NO APICAL MERISTEM (NAM) in petunia, CUP-SHAPED COTYLEDON2 (CUC2) and NAP in Arabidopsis thaliana, have crucial functions in plant development.	nac	40-43	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	120-124
10660065-3	2000	Sequence analysis revealed that the NAC genes in plants can be divided into several subfamilies, such as the NAM, ATAF, and OsNAC3 subfamilies.	nac	36-39	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	109-112
10511443-2	1999	In order to elucidate the human developmental expression profile, we used a polyclonal antiserum against the NAC domain of alpha-synuclein.	nac	109-112	synuclein alpha	Homo sapiens	123-138
10836324-9	1999	Tryptase and ECP levels were elevated in 7 of 23 and 6 of 23 NAC patients, respectively.	nac	61-64	ribonuclease A family member 3	Homo sapiens	13-16
9892646-5	1999	The beta3GnT enzyme showed a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors, whereas no activity was detected on type 1 Gal(beta1-3)GlcNAc and O-glycan core 1 Gal(beta1-3)GalNAc acceptors.	nac	67-70	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	4-12
9765297-0	1998	Purification and characterization of UDP-GlcNAc:Galbeta1-4GlcNAcbeta1-3*Galbeta1-4Glc(NAc)-R(GlcNAc to *Gal) beta1,6N-acetylglucosaminyltransferase from hog small intestine.	nac	44-47	glucosaminyl (N-acetyl) transferase 1	Homo sapiens	109-147
9600820-15	1998	Patients negative for serum squamous cell carcinoma-associated antigen (SCC) responded better to NAC than to SCC-positive cases, and SCC-negative survival was significantly better than SCC-positive survival (P < 0.05).	nac	97-100	serpin family B member 3	Homo sapiens	28-70
9785451-3	1998	Our data also show that in nitrogen-limiting conditions Nac is involved in the transcriptional repression of the gdhA gene (encoding glutamate dehydrogenase) except when L-glutamine is used as the only nitrogen source.	nac	56-59	glutamate dehydrogenase	Escherichia coli	113-117
9708867-3	1998	Somatostatin immunoreactive terminals have been previously demonstrated encircling motoneurons in the (NAc) (Cunningham, E.T., Jr. and Sawchenko, P.E., J.	nac	103-106	somatostatin	Rattus norvegicus	0-12
9600820-15	1998	Patients negative for serum squamous cell carcinoma-associated antigen (SCC) responded better to NAC than to SCC-positive cases, and SCC-negative survival was significantly better than SCC-positive survival (P < 0.05).	nac	97-100	serpin family B member 3	Homo sapiens	72-75
9159350-1	1997	To determine the effects of neoadjuvant chemotherapy (NAC) in the management of cervical carcinoma Stage IB2 (tumor diameter > 4 cm), we reviewed 52 surgically treated patients diagnosed between January 1987 and December 1993.	nac	54-57	mitogen-activated protein kinase 8 interacting protein 2	Homo sapiens	105-108
9498784-5	1998	CD4+ T cells were essential to growth inhibition mediated by NAC of PPD-positive subjects, whereas containment of M. tb by NAC of PPD-negative subjects did not require CD4+ cells.	nac	61-64	CD4 molecule	Homo sapiens	0-3
9489703-4	1998	Using differential display, a target gene of AP3/PI was identified (NAP:NAC-LIKE, ACTIVATED BY AP3/PI), which is homologous to genes required for meristem establishment and separation of floral organs.	nac	72-75	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	45-48
9489703-4	1998	Using differential display, a target gene of AP3/PI was identified (NAP:NAC-LIKE, ACTIVATED BY AP3/PI), which is homologous to genes required for meristem establishment and separation of floral organs.	nac	72-75	K-box region and MADS-box transcription factor family protein	Arabidopsis thaliana	95-98
9247192-2	1997	Presented evidences suggest that cytokeratins are bound in vitro by mammalian galectin-3 and the galectins from the sponge Geodia cydonium via their type II carbohydrate recognition domains, whose highest binding affinity is directed towards terminal alpha-N-acetylgalactosamine-bearing glycans with the general sequence GalNAcalpha1-3Gal(NAc)beta.	nac	324-327	galectin 3	Homo sapiens	78-88
8967339-5	1996	Immunofluorescence study and Northern blot analysis showed that alpha-smooth muscle actin, a marker of mesangial cell activation/dedifferentiation, was strongly expressed in NUC but faint in NAC.	nac	191-194	actin gamma 2, smooth muscle	Rattus norvegicus	64-89
8967339-6	1996	When nodules were dissolved by trypsinization, the dispersed NAC regained both active mitogenesis and alpha-smooth muscle actin expression, suggesting that the altered phenotype was reversible.	nac	61-64	actin gamma 2, smooth muscle	Rattus norvegicus	102-127
8821304-3	1995	OBJECTIVE: Quantitative determination of PGD2 in nasal secretions of atopic patients (n = 17) after nasal allergen challenge (NAC) and in non-allergic healthy volunteers (n = 10).	nac	126-129	prostaglandin D2 synthase	Homo sapiens	41-45
8558740-4	1996	One or more NAC deficiencies were found in 15 (30%) patients and included antithrombin III (n = 5), protein C (n = 8), protein S (n = 4), and heparin cofactor II (n = 2).	nac	12-15	serpin family C member 1	Homo sapiens	74-90
8670088-5	1996	A beta nac containing the sequence 1-40, 1-42 or bearing amino acid substitutions (Dutch variant of A beta) was protease-sensitive and unable to form a significant amount of amyloid even at high concentrations or after long incubations.	nac	7-10	amyloid beta precursor protein	Homo sapiens	0-6
8670088-5	1996	A beta nac containing the sequence 1-40, 1-42 or bearing amino acid substitutions (Dutch variant of A beta) was protease-sensitive and unable to form a significant amount of amyloid even at high concentrations or after long incubations.	nac	7-10	amyloid beta precursor protein	Homo sapiens	100-106
8733730-3	1996	These are highly amyloidogenic conformer (A beta ac) with a high content of beta-sheet and a slowly amyloidogenic conformer (A beta nac) with a random coil conformation.	nac	132-135	amyloid beta precursor protein	Homo sapiens	125-131
8733730-6	1996	The results suggest that, under the conditions used, apoE enhances amyloid formation by inducing the conformational transition from A beta nac into A beta ac.	nac	139-142	apolipoprotein E	Homo sapiens	53-57
8733730-6	1996	The results suggest that, under the conditions used, apoE enhances amyloid formation by inducing the conformational transition from A beta nac into A beta ac.	nac	139-142	amyloid beta precursor protein	Homo sapiens	132-138
8680652-6	1995	The frequency of four HLA-B alleles was significantly different in the melanoma compared with the NAC population: of these, HLA-B5, -B8, and -B15 had a frequency falling between the NAC and the Northern European population.	nac	98-101	major histocompatibility complex, class I, B	Homo sapiens	22-27
8830310-3	1995	We report here that AChE binds A beta nac and accelerates amyloid formation by the same peptide.	nac	38-41	acetylcholinesterase (Cartwright blood group)	Homo sapiens	20-24
8830310-2	1995	Recent studies showed that A beta 1-40 can adopt two different conformational states in solution (an amyloidogenic conformer, A beta ac, and a non-amyloidogenic conformer, A beta nac) which have distinct abilities to form amyloid fibrils.	nac	179-182	amyloid beta precursor protein	Homo sapiens	27-33
8830310-3	1995	We report here that AChE binds A beta nac and accelerates amyloid formation by the same peptide.	nac	38-41	amyloid beta precursor protein	Homo sapiens	31-37
8830310-4	1995	No such effect was observed with A beta ac, the amyloidogenic conformer, suggesting that AChE acts as a "pathological chaperone" inducing a conformational transition from A beta nac into A beta ac in vitro.	nac	178-181	acetylcholinesterase (Cartwright blood group)	Homo sapiens	89-93
8830310-4	1995	No such effect was observed with A beta ac, the amyloidogenic conformer, suggesting that AChE acts as a "pathological chaperone" inducing a conformational transition from A beta nac into A beta ac in vitro.	nac	178-181	amyloid beta precursor protein	Homo sapiens	171-177
8830310-4	1995	No such effect was observed with A beta ac, the amyloidogenic conformer, suggesting that AChE acts as a "pathological chaperone" inducing a conformational transition from A beta nac into A beta ac in vitro.	nac	178-181	amyloid beta precursor protein	Homo sapiens	171-177
8680652-6	1995	The frequency of four HLA-B alleles was significantly different in the melanoma compared with the NAC population: of these, HLA-B5, -B8, and -B15 had a frequency falling between the NAC and the Northern European population.	nac	182-185	major histocompatibility complex, class I, B	Homo sapiens	22-27
7895867-19	1995	However, NAC increased ED50 for hPTC and hAG, and BSO reduced ED50 for hPTC and hAG.	nac	9-12	coiled-coil domain containing 6	Homo sapiens	32-44
7895867-20	1995	The effects of NAC and BSO on ED50 for hPTC were greater than those for hAG.	nac	15-18	coiled-coil domain containing 6	Homo sapiens	39-43
1935514-3	1991	Immunostaining for factor VIII and vimentin was strongly positive in the malignant spindly polygonal endothelial cells and further supported the NAC diagnosis.	nac	145-148	vimentin	Homo sapiens	35-43
1412412-3	1992	In this relatively small population, certain alleles such as DRB1*0406 and 0411 were encountered only in Hispanics, while others such as DRB1*0403, 0408 and 0409 were found only in NAC (North American Caucasians).	nac	181-184	major histocompatibility complex, class II, DR beta 1	Homo sapiens	137-141
1990978-5	1991	Treatment of IREC with the glutathione reductase inhibitor, 1,3-bis(2-chloroethyl)-1-nitrosourea, potentiated the thiol depletion and toxicity observed with menadione and M(NAC)NQ indicating the involvement of oxidative stress in this model of renal cell toxicity.	nac	173-176	glutathione-disulfide reductase	Rattus norvegicus	27-48
7734974-7	1995	Most ECP concentrations (94%) increased slowly 1 h after NAC and reached a significantly higher level 24 h later.	nac	57-60	ribonuclease A family member 3	Homo sapiens	5-8
7982215-0	1994	Synthesis of the 5-aminopentyl glycoside of beta-D-Gal p-(1-->4)-beta-D-Glc p NAc-(1-->3)-L-Fuc p and fragments thereof related to glycopeptides of human Christmas factor and the marine sponge Microciona prolifera.	nac	81-84	coagulation factor IX	Homo sapiens	160-176
7976971-7	1994	However, the difference that occurred was that ECP reached its highest concentration (median: 401 ng/g, range: 32-2298 ng/g) only 24 hours after NAC, while the percentage of the eosinophils decreased.	nac	145-148	ribonuclease A family member 3	Homo sapiens	47-50
1552225-9	1992	Granulocyte-macrophage colony-forming units (CFU-GM) yields for nac from IL-3 LTBMCs were consistently higher than those for nac from GM-CSF LTBMCs.	nac	64-67	interleukin 3	Homo sapiens	73-77
1552225-10	1992	Ara-C exposure reduced CFU-GM numbers generated with nac from GM-CSF LTBMCs to 10% of GM-CSF controls (week 1).	nac	53-56	colony stimulating factor 2	Homo sapiens	62-68
1552225-11	1992	However, CFU-GM numbers grown with nac from Ara-C exposed GM-CSF-dependent LTBMCs recovered above control levels after week 3.	nac	35-38	colony stimulating factor 2	Homo sapiens	58-64
33813230-3	2021	METHODS: Magseed , a non-radioactive magnetic marker was used to mark the biopsied positive TLN after NAC.	nac	102-105	intercellular adhesion molecule 5	Homo sapiens	92-95
1703862-1	1990	Human red cells (RBC) were treated with endo-beta-galactosidase from Bacteroides fragilis removing type 2 polylactosamine chains [Galssl-4GlcNAc]n from the RBC surface by cleaving internal Galssl-4Glc(NAc) bonds of linear lactosamine sequences.	nac	141-144	galactosidase beta 1	Homo sapiens	45-63
33237063-6	2020	Furthermore, to better understand the sensing mechanism, we attempt to use solid-state NMR and X-ray photoelectron spectroscopy to vividly characterize the charge transfer caused by the interaction between NAC molecules and the MOF at the molecular level.	nac	206-209	lysine acetyltransferase 8	Homo sapiens	228-231
33766713-6	2021	CCTalpha provided predictive information about the efficacy of NAC (interaction P=0.009).	nac	63-66	phosphate cytidylyltransferase 1A, choline	Homo sapiens	0-8
33766713-8	2021	The adjusted hazard ratio for NAC treated versus no-NAC was 0.42 (95% CI: 0.27-0.64) for patients with negative CCTalpha expression, when adding information about emmprin it decreased to 0.33 (95% CI: 0.19-0.56) for patients with both negative CCTalpha and emmprin.	nac	30-33	phosphate cytidylyltransferase 1A, choline	Homo sapiens	112-120
33766713-8	2021	The adjusted hazard ratio for NAC treated versus no-NAC was 0.42 (95% CI: 0.27-0.64) for patients with negative CCTalpha expression, when adding information about emmprin it decreased to 0.33 (95% CI: 0.19-0.56) for patients with both negative CCTalpha and emmprin.	nac	30-33	basigin (Ok blood group)	Homo sapiens	163-170
33766713-8	2021	The adjusted hazard ratio for NAC treated versus no-NAC was 0.42 (95% CI: 0.27-0.64) for patients with negative CCTalpha expression, when adding information about emmprin it decreased to 0.33 (95% CI: 0.19-0.56) for patients with both negative CCTalpha and emmprin.	nac	30-33	phosphate cytidylyltransferase 1A, choline	Homo sapiens	244-252
33766713-8	2021	The adjusted hazard ratio for NAC treated versus no-NAC was 0.42 (95% CI: 0.27-0.64) for patients with negative CCTalpha expression, when adding information about emmprin it decreased to 0.33 (95% CI: 0.19-0.56) for patients with both negative CCTalpha and emmprin.	nac	30-33	basigin (Ok blood group)	Homo sapiens	257-264
33766713-8	2021	The adjusted hazard ratio for NAC treated versus no-NAC was 0.42 (95% CI: 0.27-0.64) for patients with negative CCTalpha expression, when adding information about emmprin it decreased to 0.33 (95% CI: 0.19-0.56) for patients with both negative CCTalpha and emmprin.	nac	52-55	phosphate cytidylyltransferase 1A, choline	Homo sapiens	112-120
33766713-8	2021	The adjusted hazard ratio for NAC treated versus no-NAC was 0.42 (95% CI: 0.27-0.64) for patients with negative CCTalpha expression, when adding information about emmprin it decreased to 0.33 (95% CI: 0.19-0.56) for patients with both negative CCTalpha and emmprin.	nac	52-55	basigin (Ok blood group)	Homo sapiens	163-170
33784411-9	2021	Following INCS treatment, IL-2, IL-4, IL-5 and IL-13 were significantly attenuated 24h post-NAC accompanied by significant improvement in upper airway function.	nac	92-95	interleukin 2	Homo sapiens	26-30
33784411-9	2021	Following INCS treatment, IL-2, IL-4, IL-5 and IL-13 were significantly attenuated 24h post-NAC accompanied by significant improvement in upper airway function.	nac	92-95	interleukin 4	Homo sapiens	32-36
33784411-9	2021	Following INCS treatment, IL-2, IL-4, IL-5 and IL-13 were significantly attenuated 24h post-NAC accompanied by significant improvement in upper airway function.	nac	92-95	interleukin 5	Homo sapiens	38-42
33784411-9	2021	Following INCS treatment, IL-2, IL-4, IL-5 and IL-13 were significantly attenuated 24h post-NAC accompanied by significant improvement in upper airway function.	nac	92-95	interleukin 13	Homo sapiens	47-52
33817122-1	2018	NAC (for NAM, ATAF1-2, and CUC2) proteins are one of the largest transcription factor families in plants.	nac	0-3	NO APICAL MERISTEM	Solanum lycopersicum	9-12
34522005-6	2022	The behavioural effect of cocaine was attenuated by intra-NAc administration of LY294002, an AKT-specific inhibitor, suggesting that PIPs may contribute to mTOR activation in response to cocaine.	nac	58-61	thymoma viral proto-oncogene 1	Mus musculus	93-96
34522005-6	2022	The behavioural effect of cocaine was attenuated by intra-NAc administration of LY294002, an AKT-specific inhibitor, suggesting that PIPs may contribute to mTOR activation in response to cocaine.	nac	58-61	mechanistic target of rapamycin kinase	Mus musculus	156-160
34522005-8	2022	In contrast, AAV-mediated SynDIG1 overexpression in NAc attenuated intracellular GluA2 internalization by promoting the SynDIG1-GluA2 interaction, thus maintaining GluA2 surface expression and repressing cocaine-induced behaviours.	nac	52-55	synapse differentiation inducing 1	Mus musculus	26-33
34522005-8	2022	In contrast, AAV-mediated SynDIG1 overexpression in NAc attenuated intracellular GluA2 internalization by promoting the SynDIG1-GluA2 interaction, thus maintaining GluA2 surface expression and repressing cocaine-induced behaviours.	nac	52-55	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	81-86
34522005-8	2022	In contrast, AAV-mediated SynDIG1 overexpression in NAc attenuated intracellular GluA2 internalization by promoting the SynDIG1-GluA2 interaction, thus maintaining GluA2 surface expression and repressing cocaine-induced behaviours.	nac	52-55	synapse differentiation inducing 1	Mus musculus	120-127
34522005-8	2022	In contrast, AAV-mediated SynDIG1 overexpression in NAc attenuated intracellular GluA2 internalization by promoting the SynDIG1-GluA2 interaction, thus maintaining GluA2 surface expression and repressing cocaine-induced behaviours.	nac	52-55	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	128-133
34522005-8	2022	In contrast, AAV-mediated SynDIG1 overexpression in NAc attenuated intracellular GluA2 internalization by promoting the SynDIG1-GluA2 interaction, thus maintaining GluA2 surface expression and repressing cocaine-induced behaviours.	nac	52-55	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	164-169
34893233-6	2022	In the animal experiments, CS-NAC/ALG/TCP improved the oxidative stress status of the gastric mucosa by increasing the levels of SOD, GSH, and CAT in tissues.	nac	30-33	catalase	Mus musculus	143-146
34618923-7	2021	ZmMPK5 directly phosphorylates Thr-26 in NAC subdomain A of ZmNAC49.	nac	41-44	MAP kinase 2	Zea mays	0-6
34379229-2	2022	This phase II study investigated the efficacy and safety of S-1 and oxaliplatin (SOX) as neoadjuvant chemotherapy (NAC) for LAGC and esophagogastric junction cancer (EGJC).	nac	115-118	proteasome 26S subunit, non-ATPase 1	Homo sapiens	60-79
34987618-3	2021	The aim of our study is to evaluate the safety, feasibility, and efficacy of the addition of dendritic cell vaccines (DCV) to NAC in HER2-negative BC patients.	nac	126-129	erb-b2 receptor tyrosine kinase 2	Homo sapiens	133-137
34956864-6	2021	Results: In pre-treatment biopsies, TREM1 and known TREM-1 inducible cytokines (IL1B, IL8) were discovered by a statistical ranking procedure as top genes for which high expression was associated with reduced response to NAC, but only in the context of immunologically "hot" tumors otherwise associated with a high NAC response rate.	nac	221-224	triggering receptor expressed on myeloid cells 1	Homo sapiens	36-41
34956864-6	2021	Results: In pre-treatment biopsies, TREM1 and known TREM-1 inducible cytokines (IL1B, IL8) were discovered by a statistical ranking procedure as top genes for which high expression was associated with reduced response to NAC, but only in the context of immunologically "hot" tumors otherwise associated with a high NAC response rate.	nac	221-224	triggering receptor expressed on myeloid cells 1	Homo sapiens	52-58
34956864-6	2021	Results: In pre-treatment biopsies, TREM1 and known TREM-1 inducible cytokines (IL1B, IL8) were discovered by a statistical ranking procedure as top genes for which high expression was associated with reduced response to NAC, but only in the context of immunologically "hot" tumors otherwise associated with a high NAC response rate.	nac	221-224	interleukin 1 beta	Homo sapiens	80-84
34956864-6	2021	Results: In pre-treatment biopsies, TREM1 and known TREM-1 inducible cytokines (IL1B, IL8) were discovered by a statistical ranking procedure as top genes for which high expression was associated with reduced response to NAC, but only in the context of immunologically "hot" tumors otherwise associated with a high NAC response rate.	nac	221-224	C-X-C motif chemokine ligand 8	Homo sapiens	86-89
34950580-12	2021	Response to NAC in tumors with high TCR clonality may be attributable to high infiltration and expansion of tumor-specific CD8 positive effector cells.	nac	12-15	CD8a molecule	Homo sapiens	123-126
34844154-11	2021	Moreover, MDA expression was significantly lower in the OV, quercetin, quercetin + OV, and NAC groups than in the model group (P < 0.05), while SOD, eNOS, and ATP levels were higher.	nac	91-94	nitric oxide synthase 3	Rattus norvegicus	149-153
34520828-10	2022	Antioxidant NAC significantly reduced LDH, ROS and 8-OHdG, inhibited the phosphorylation of AMPKThr172 and ULK1Ser317, and down-regulated autophagosomes and proteins expression levels of LC3 and Beclin-1.	nac	12-15	annexin A3	Rattus norvegicus	187-190
34520828-10	2022	Antioxidant NAC significantly reduced LDH, ROS and 8-OHdG, inhibited the phosphorylation of AMPKThr172 and ULK1Ser317, and down-regulated autophagosomes and proteins expression levels of LC3 and Beclin-1.	nac	12-15	beclin 1	Rattus norvegicus	195-203
34618923-7	2021	ZmMPK5 directly phosphorylates Thr-26 in NAC subdomain A of ZmNAC49.	nac	41-44	NAC domain-containing protein 2	Zea mays	60-67
34708307-8	2022	Multivariate analysis revealed that cN2-3, increased serum SCC-Ag levels, and clinical response to NAC were independent predictors of ER.	nac	99-102	epiregulin	Homo sapiens	134-136
34798483-2	2021	It has been previously reported that multiple genes in the CENPA-nucleosome associated complex (NAC) complex in lung cancer can be used as prognostic markers; however, there is lack of comprehensive research on the CENPA-NAC complex.	nac	221-224	centromere protein A	Homo sapiens	215-220
34539859-5	2021	The present study aimed to determine the association between TBX2 protein expression in tumor tissues and the efficacy of NAC in locally advanced uterine cervical squamous cell carcinoma using immunohistochemistry.	nac	122-125	T-box transcription factor 2	Homo sapiens	61-65
34539859-10	2021	Tumors from the NAC effective group also had significantly downregulated TBX2 expression levels compared with those from the NAC ineffective group (P=0.0138).	nac	16-19	T-box transcription factor 2	Homo sapiens	73-77
34539859-10	2021	Tumors from the NAC effective group also had significantly downregulated TBX2 expression levels compared with those from the NAC ineffective group (P=0.0138).	nac	125-128	T-box transcription factor 2	Homo sapiens	73-77
34539859-11	2021	Of note, decreased TBX2 expression was indicated to be significantly associated with higher sensitivity to NAC (P=0.009).	nac	107-110	T-box transcription factor 2	Homo sapiens	19-23
34539859-14	2021	In conclusion, the results of the present study suggested that TBX2 expression may be a useful predictor of the response to NAC in patients with locally advanced uterine cervical squamous cell carcinoma.	nac	124-127	T-box transcription factor 2	Homo sapiens	63-67
34617979-3	2021	Objective: To evaluate nodal recurrence rates in a consecutive cohort of patients with clinically node-positive (cN1) breast cancer receiving NAC, followed by a negative SLNB using a standardized technique, and no further axillary surgery.	nac	142-145	5'-nucleotidase, cytosolic IA	Homo sapiens	113-116
34617979-9	2021	Results: Of 610 patients with cN1 breast cancer treated with NAC (median (IQR) age, 49 (40-58) years), 555 (91%) converted to cN0 and underwent SLNB; 234 (42%) had 3 or more negative SLNs and had SLNB alone.	nac	61-64	5'-nucleotidase, cytosolic IA	Homo sapiens	30-33
34868273-12	2021	Conclusion: The Rad-score derived from preoperative MRI features is an independent biomarker for DFS prediction in patients with TNBC to NAC, and the combined radiomics nomogram improved individualized DFS estimation.	nac	137-140	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	16-19
34387763-2	2021	METHOD: We retrospectively analyzed data on 313 patients with clinical stage of cT1-4N0-3M0 who underwent laparoscopic radical gastrectomy after NAC between February 2010 and October 2020 from two hospitals in China.	nac	145-148	cardiotrophin 1	Homo sapiens	80-83
34390773-6	2021	In the NAc, morphine increased D1R, D2R, D3R, DAT, GluA1 and MOR immunoreactivity.	nac	7-10	solute carrier family 6 member 3	Rattus norvegicus	46-49
34390773-6	2021	In the NAc, morphine increased D1R, D2R, D3R, DAT, GluA1 and MOR immunoreactivity.	nac	7-10	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	51-56
34708307-10	2022	Extensive lymph node metastasis, an elevated SCC-Ag, and inadequate response to NAC were identified as predictors of ER.	nac	80-83	epiregulin	Homo sapiens	117-119
34829324-2	2021	In 105 patients with osteosarcoma, 18F-FDG positron emission tomography/computed tomography (PET/CT) images were acquired before (baseline PET0) and after NAC (PET1).	nac	155-158	FEV transcription factor, ETS family member	Homo sapiens	160-164
34281882-5	2021	RESULTS: The biopsy specimens of the non-responders had the CD44high/CD24low expression at high levels, which was found as an independent predictor of not only FP-NAC resistance but also poor overall survival by multivariate analyses.	nac	163-166	CD44 molecule (Indian blood group)	Homo sapiens	60-64
34326131-12	2021	CONCLUSIONS: Adding GEN-1 to standard NAC is safe, appears active and impacts the tumor microenvironment.	nac	38-41	GEN1 Holliday junction 5' flap endonuclease	Homo sapiens	20-25
34633775-12	2021	CONCLUSIONS: Standard NAC cycles were associated with a significant survival benefit, especially in patients with HER2 positive or triple negative breast cancer.	nac	22-25	erb-b2 receptor tyrosine kinase 2	Homo sapiens	114-118
34537675-7	2021	RESULTS: Clinical American Joint Committee on Cancer stage, grade, estrogen receptor expression, human epidermal growth factor receptor 2 (HER2) status and treatment, Ki-67 expression, lymphovascular invasion, and residual cancer burden were identified as independent prognostic variables for BC treated with NAC.	nac	309-312	estrogen receptor 1	Homo sapiens	67-84
34537675-7	2021	RESULTS: Clinical American Joint Committee on Cancer stage, grade, estrogen receptor expression, human epidermal growth factor receptor 2 (HER2) status and treatment, Ki-67 expression, lymphovascular invasion, and residual cancer burden were identified as independent prognostic variables for BC treated with NAC.	nac	309-312	erb-b2 receptor tyrosine kinase 2	Homo sapiens	103-137
34537675-7	2021	RESULTS: Clinical American Joint Committee on Cancer stage, grade, estrogen receptor expression, human epidermal growth factor receptor 2 (HER2) status and treatment, Ki-67 expression, lymphovascular invasion, and residual cancer burden were identified as independent prognostic variables for BC treated with NAC.	nac	309-312	erb-b2 receptor tyrosine kinase 2	Homo sapiens	139-143
34650437-8	2021	Blocking the activation of PERK/eIF-2alpha/ATF4 signaling pathway either by Nox4 shRNA, ROS scavenger (NAC) or PERK inhibitor (GSK2606414) significantly inhibited autophagy during RANKL-induced osteoclastogenesis.	nac	103-106	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	27-31
34650437-8	2021	Blocking the activation of PERK/eIF-2alpha/ATF4 signaling pathway either by Nox4 shRNA, ROS scavenger (NAC) or PERK inhibitor (GSK2606414) significantly inhibited autophagy during RANKL-induced osteoclastogenesis.	nac	103-106	eukaryotic translation initiation factor 2A	Homo sapiens	32-42
34650437-8	2021	Blocking the activation of PERK/eIF-2alpha/ATF4 signaling pathway either by Nox4 shRNA, ROS scavenger (NAC) or PERK inhibitor (GSK2606414) significantly inhibited autophagy during RANKL-induced osteoclastogenesis.	nac	103-106	activating transcription factor 4	Homo sapiens	43-47
34650437-8	2021	Blocking the activation of PERK/eIF-2alpha/ATF4 signaling pathway either by Nox4 shRNA, ROS scavenger (NAC) or PERK inhibitor (GSK2606414) significantly inhibited autophagy during RANKL-induced osteoclastogenesis.	nac	103-106	TNF superfamily member 11	Homo sapiens	180-185
34733729-9	2021	Results: Up-regulation of YAP1/MMP7 and down-regulation of CXCL16 were both significant in TNBC cases with poor NAC response.	nac	112-115	Yes1 associated transcriptional regulator	Homo sapiens	26-30
34733729-9	2021	Results: Up-regulation of YAP1/MMP7 and down-regulation of CXCL16 were both significant in TNBC cases with poor NAC response.	nac	112-115	matrix metallopeptidase 7	Homo sapiens	31-35
34733729-9	2021	Results: Up-regulation of YAP1/MMP7 and down-regulation of CXCL16 were both significant in TNBC cases with poor NAC response.	nac	112-115	C-X-C motif chemokine ligand 16	Homo sapiens	59-65
34733729-13	2021	The ROC curve also supported the predictive value of YAP1/MMP7/CXCL16 axis and TILs density in NAC response prospect.	nac	95-98	Yes1 associated transcriptional regulator	Homo sapiens	53-57
34733729-13	2021	The ROC curve also supported the predictive value of YAP1/MMP7/CXCL16 axis and TILs density in NAC response prospect.	nac	95-98	matrix metallopeptidase 7	Homo sapiens	58-62
34733729-13	2021	The ROC curve also supported the predictive value of YAP1/MMP7/CXCL16 axis and TILs density in NAC response prospect.	nac	95-98	C-X-C motif chemokine ligand 16	Homo sapiens	63-69
34733729-16	2021	Conclusions: Over expression of causes up-regulation of MMP7 and down-regulation of CXCL16, which suppressed CD4+/CD8+ TILs recruitment and indirectly affected NAC response of TNBC patients.	nac	160-163	matrix metallopeptidase 7	Homo sapiens	56-60
34733729-16	2021	Conclusions: Over expression of causes up-regulation of MMP7 and down-regulation of CXCL16, which suppressed CD4+/CD8+ TILs recruitment and indirectly affected NAC response of TNBC patients.	nac	160-163	C-X-C motif chemokine ligand 16	Homo sapiens	84-90
34432650-12	2021	Inhibition of ROS by NAC attenuated cardiocytes aging and inhibited the NLRP3 inflammasome activation at the same time.	nac	21-24	NLR family, pyrin domain containing 3	Rattus norvegicus	72-77
34359804-7	2021	Corroboration with differential gene expression analysis revealed cyclic nucleotide-gated channel, CNGB1, as the top ranked upregulated gene in non-responders to NAC.	nac	162-165	cyclic nucleotide gated channel subunit beta 1	Homo sapiens	99-104
34363828-2	2021	We administered morphine (10 mg/kg; MOR) to induce locomotor sensitization and ERK activation in the VTA and NAc.	nac	109-112	Eph receptor B1	Rattus norvegicus	79-82
34616393-10	2021	Secondly, our data reveal a correlation between the alterations observed in IL1beta, IBA1 levels, and MOR levels in the PFC and NAc of CFA-treated female rats.	nac	128-131	interleukin 1 alpha	Rattus norvegicus	76-83
34616393-10	2021	Secondly, our data reveal a correlation between the alterations observed in IL1beta, IBA1 levels, and MOR levels in the PFC and NAc of CFA-treated female rats.	nac	128-131	allograft inflammatory factor 1	Rattus norvegicus	85-89
34097428-7	2021	Furthermore, patients with HER2+ tumors were more likely to have increased TIM-3 expression on CD8+ T cells (p = 0.043), whereas patients with a better response to NAC were more likely to express TIGIT on CD8+ T (p = 0.014) and CD16- CD56bright NK cells (p = 0.003), respectively.	nac	164-167	T cell immunoreceptor with Ig and ITIM domains	Homo sapiens	196-201
34097428-7	2021	Furthermore, patients with HER2+ tumors were more likely to have increased TIM-3 expression on CD8+ T cells (p = 0.043), whereas patients with a better response to NAC were more likely to express TIGIT on CD8+ T (p = 0.014) and CD16- CD56bright NK cells (p = 0.003), respectively.	nac	164-167	Fc gamma receptor IIIa	Homo sapiens	228-232
34097428-7	2021	Furthermore, patients with HER2+ tumors were more likely to have increased TIM-3 expression on CD8+ T cells (p = 0.043), whereas patients with a better response to NAC were more likely to express TIGIT on CD8+ T (p = 0.014) and CD16- CD56bright NK cells (p = 0.003), respectively.	nac	164-167	neural cell adhesion molecule 1	Homo sapiens	234-238
34197905-8	2021	Together, our study provides initial evidence relevant to the transcriptional change of grk2 gene in the NAc shell after excessive alcohol drinking.	nac	105-108	G protein-coupled receptor kinase 2	Mus musculus	88-92
34281882-6	2021	CONCLUSION: CD44high/CD24low expression in the biopsy specimens prior to FP-NAC may be a predictor of FP-NAC resistance and poor prognosis of ESCC patients.	nac	105-108	CD44 molecule (Indian blood group)	Homo sapiens	12-16
34281882-6	2021	CONCLUSION: CD44high/CD24low expression in the biopsy specimens prior to FP-NAC may be a predictor of FP-NAC resistance and poor prognosis of ESCC patients.	nac	105-108	CD24 molecule	Homo sapiens	21-25
34281882-5	2021	RESULTS: The biopsy specimens of the non-responders had the CD44high/CD24low expression at high levels, which was found as an independent predictor of not only FP-NAC resistance but also poor overall survival by multivariate analyses.	nac	163-166	CD24 molecule	Homo sapiens	69-73
34393098-12	2022	CONCLUSION: Histological variants and CAIX immune-expression are biomarkers of nonresponse to NAC of MIBC, and might be easily used in the clinical practice to select patients to be submitted to surgery upfront.	nac	94-97	carbonic anhydrase 9	Homo sapiens	38-42
34315723-8	2021	CONCLUSIONS: Tumor-specific MHC-II has strong candidacy as a specific biomarker of anti-PD-1/L1 immunotherapy benefit when added to standard NAC in HER2-negative breast cancer.	nac	141-144	spermatogenesis associated 2	Homo sapiens	88-92
34247514-8	2021	RESULTS: The changes were statistically significant on slope, maximum signal intensity (SImax), time to peak (TTP), signal enhanced extent (SEE), peak percent enhancement (PPE), washout rate (WOR), and enhancement rate (ER) in the good response group (P < 0.05), while only SImax and SEE were different in the non-response group after NAC.	nac	335-338	epiregulin	Homo sapiens	220-222
34282214-10	2021	The clinical tumor (T) stage, NLR, MLR, PLR, PIV, estrogen receptor (ER) status, human epidermal growth factor receptor-2 (HER-2) status, and Ki-67 index were significantly associated with NAC response in univariate analyses.	nac	189-192	estrogen receptor 1	Homo sapiens	50-67
34282214-10	2021	The clinical tumor (T) stage, NLR, MLR, PLR, PIV, estrogen receptor (ER) status, human epidermal growth factor receptor-2 (HER-2) status, and Ki-67 index were significantly associated with NAC response in univariate analyses.	nac	189-192	estrogen receptor 1	Homo sapiens	69-71
34282214-10	2021	The clinical tumor (T) stage, NLR, MLR, PLR, PIV, estrogen receptor (ER) status, human epidermal growth factor receptor-2 (HER-2) status, and Ki-67 index were significantly associated with NAC response in univariate analyses.	nac	189-192	erb-b2 receptor tyrosine kinase 2	Homo sapiens	87-121
34282214-10	2021	The clinical tumor (T) stage, NLR, MLR, PLR, PIV, estrogen receptor (ER) status, human epidermal growth factor receptor-2 (HER-2) status, and Ki-67 index were significantly associated with NAC response in univariate analyses.	nac	189-192	erb-b2 receptor tyrosine kinase 2	Homo sapiens	123-128
34247514-9	2021	The changes in Slope, SImax, TTP, SEE, WOR, and ER were markedly different (P < 0.05) between the two groups after NAC.	nac	115-118	epiregulin	Homo sapiens	48-50
34247514-11	2021	CONCLUSION: Slope, TTP, and ER values could be used to evaluate and predict the response to NAC in osteosarcoma.	nac	92-95	epiregulin	Homo sapiens	28-30
34235079-8	2021	Conclusion: Ki67 index changes and RD TIL levels were associated with the prognosis of patients with primary TNBC with RD after NAC.	nac	128-131	toll like receptor 1	Homo sapiens	38-41
34367759-7	2021	Insurance status was a predictor for any clinical response to NAC in both univariable and multivariable analyses (p<0.01), where odds of pCR or pPR were lower for patients with Medicare compared to private insurance (OR 0.32, 95% CI: 0.15-0.70, p<0.01).	nac	62-65	PPR1	Homo sapiens	144-147
34205689-0	2021	Administration of AAV-Alpha Synuclein NAC Antibody Improves Locomotor Behavior in Rats Overexpressing Alpha Synuclein.	nac	38-41	synuclein alpha	Rattus norvegicus	102-117
34239995-9	2021	Specifically, the presence of somatic mutations of APC, ATM, CDH9, CTNNB1, METTL3, NBEAL1, PTPRH, RNASEL, and FBXW7 in NAC responder signifies that these mutations were potential predictors of pathological response to NAC.	nac	218-221	ATM serine/threonine kinase	Homo sapiens	56-59
34117262-10	2021	HER2-positive patients can achieve a higher LN pCR rate with dose-dense NAC than with standard-interval NAC with trastuzumab.	nac	72-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
34239995-9	2021	Specifically, the presence of somatic mutations of APC, ATM, CDH9, CTNNB1, METTL3, NBEAL1, PTPRH, RNASEL, and FBXW7 in NAC responder signifies that these mutations were potential predictors of pathological response to NAC.	nac	218-221	cadherin 9	Homo sapiens	61-65
34239995-9	2021	Specifically, the presence of somatic mutations of APC, ATM, CDH9, CTNNB1, METTL3, NBEAL1, PTPRH, RNASEL, and FBXW7 in NAC responder signifies that these mutations were potential predictors of pathological response to NAC.	nac	218-221	catenin beta 1	Homo sapiens	67-73
34239995-9	2021	Specifically, the presence of somatic mutations of APC, ATM, CDH9, CTNNB1, METTL3, NBEAL1, PTPRH, RNASEL, and FBXW7 in NAC responder signifies that these mutations were potential predictors of pathological response to NAC.	nac	218-221	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	75-81
34149935-2	2021	However, HER2 discrepancies occur before and after surgery, creating difficulties in the administration of appropriate NAC.	nac	119-122	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-13
34149935-10	2021	The HER2 discordance rate was 12.5% in the no NAC group and 23.7% in the NAC group.	nac	46-49	erb-b2 receptor tyrosine kinase 2	Homo sapiens	4-8
34149935-10	2021	The HER2 discordance rate was 12.5% in the no NAC group and 23.7% in the NAC group.	nac	73-76	erb-b2 receptor tyrosine kinase 2	Homo sapiens	4-8
34149935-12	2021	Clinicopathological factors affecting HER2 change in the no NAC group were larger tumor size and higher histologic grade.	nac	60-63	erb-b2 receptor tyrosine kinase 2	Homo sapiens	38-42
34239995-9	2021	Specifically, the presence of somatic mutations of APC, ATM, CDH9, CTNNB1, METTL3, NBEAL1, PTPRH, RNASEL, and FBXW7 in NAC responder signifies that these mutations were potential predictors of pathological response to NAC.	nac	218-221	neurobeachin like 1	Homo sapiens	83-89
34239995-9	2021	Specifically, the presence of somatic mutations of APC, ATM, CDH9, CTNNB1, METTL3, NBEAL1, PTPRH, RNASEL, and FBXW7 in NAC responder signifies that these mutations were potential predictors of pathological response to NAC.	nac	218-221	protein tyrosine phosphatase receptor type H	Homo sapiens	91-96
34239995-9	2021	Specifically, the presence of somatic mutations of APC, ATM, CDH9, CTNNB1, METTL3, NBEAL1, PTPRH, RNASEL, and FBXW7 in NAC responder signifies that these mutations were potential predictors of pathological response to NAC.	nac	218-221	ribonuclease L	Homo sapiens	98-104
34149935-13	2021	Meanwhile, poor response to prior chemotherapy affected HER2 change in NAC.	nac	71-74	erb-b2 receptor tyrosine kinase 2	Homo sapiens	56-60
34239995-9	2021	Specifically, the presence of somatic mutations of APC, ATM, CDH9, CTNNB1, METTL3, NBEAL1, PTPRH, RNASEL, and FBXW7 in NAC responder signifies that these mutations were potential predictors of pathological response to NAC.	nac	218-221	F-box and WD repeat domain containing 7	Homo sapiens	110-115
34149935-14	2021	Conclusion: The overall accuracy of CNB in determining HER2 status was lower in the NAC group than in the no NAC group.	nac	84-87	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-59
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	119-122	coiled-coil domain containing 141	Homo sapiens	34-41
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	119-122	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	43-49
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	119-122	chromodomain helicase DNA binding protein 5	Homo sapiens	51-55
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	119-122	G protein-coupled receptor 149	Homo sapiens	57-63
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	119-122	mucin 20, cell surface associated	Homo sapiens	65-70
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	119-122	TSC complex subunit 1	Homo sapiens	72-76
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	119-122	ubiquitin specific peptidase 54	Homo sapiens	82-87
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	204-207	coiled-coil domain containing 141	Homo sapiens	34-41
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	204-207	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	43-49
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	204-207	chromodomain helicase DNA binding protein 5	Homo sapiens	51-55
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	204-207	G protein-coupled receptor 149	Homo sapiens	57-63
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	204-207	mucin 20, cell surface associated	Homo sapiens	65-70
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	204-207	TSC complex subunit 1	Homo sapiens	72-76
34239995-10	2021	Furthermore, somatic mutations of CCDC141, PIK3CA, CHD5, GPR149, MUC20, TSC1, and USP54 were exclusively identified in NAC nonresponders, suggesting that these mutations may participate in the process of NAC resistance.	nac	204-207	ubiquitin specific peptidase 54	Homo sapiens	82-87
34239995-11	2021	In the validation cohort, the somatic mutations of CDH9, METTL3, and PTPRH were significantly enriched in NAC responders while the somatic mutation of CCDC141 was significantly enriched in NAC nonresponders.	nac	106-109	cadherin 9	Homo sapiens	51-55
34239995-11	2021	In the validation cohort, the somatic mutations of CDH9, METTL3, and PTPRH were significantly enriched in NAC responders while the somatic mutation of CCDC141 was significantly enriched in NAC nonresponders.	nac	106-109	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	57-63
34239995-11	2021	In the validation cohort, the somatic mutations of CDH9, METTL3, and PTPRH were significantly enriched in NAC responders while the somatic mutation of CCDC141 was significantly enriched in NAC nonresponders.	nac	106-109	protein tyrosine phosphatase receptor type H	Homo sapiens	69-74
34239995-11	2021	In the validation cohort, the somatic mutations of CDH9, METTL3, and PTPRH were significantly enriched in NAC responders while the somatic mutation of CCDC141 was significantly enriched in NAC nonresponders.	nac	189-192	coiled-coil domain containing 141	Homo sapiens	151-158
34136426-9	2021	The pCR rates after NAC were 64.3% for human epidermal growth factor receptor 2 positive and triple-negative tumors and 13.6% in luminal tumors (P = 0.0002).	nac	20-23	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-79
34239995-13	2021	Conclusion: The somatic mutation of METTL3 can be a potential predictive biomarker of NAC response in MIBC patients.	nac	86-89	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	36-42
34239995-14	2021	Relevance for Patients: MIBC patients bearing mutated METTL3 display a pathological response to NAC and have a significantly longer overall survival or disease/progression-free survival as compared to the patients bearing wild-type METTL3.	nac	96-99	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	54-60
34239995-15	2021	Thus, the somatic mutation of METTL3 is a potential biomarker for predicting response to NAC in MIBC patients, assisting doctors in making the clinical decision.	nac	89-92	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	30-36
34123431-2	2021	However, more information is needed to characterize the relationship between patterns of HER2 testing results and response to NAC.	nac	126-129	erb-b2 receptor tyrosine kinase 2	Homo sapiens	89-93
34073233-11	2021	Patients with MIBC showing a high expression of ERBB2, ESR1, or KRT20 have a significantly higher chance of pCR following NAC.	nac	122-125	erb-b2 receptor tyrosine kinase 2	Homo sapiens	48-53
34073233-11	2021	Patients with MIBC showing a high expression of ERBB2, ESR1, or KRT20 have a significantly higher chance of pCR following NAC.	nac	122-125	estrogen receptor 1	Homo sapiens	55-59
34123431-3	2021	We evaluated clinicopathologic characteristics associated with RCB categories in HER2+ patients who underwent HER2-directed NAC.	nac	124-127	erb-b2 receptor tyrosine kinase 2	Homo sapiens	110-114
34104541-6	2021	The density of CD8+ cells was decreased and the density of FoxP3+ cells and CD20+ cells was increased in PT post-NAC.	nac	113-116	CD8a molecule	Homo sapiens	15-18
34104541-6	2021	The density of CD8+ cells was decreased and the density of FoxP3+ cells and CD20+ cells was increased in PT post-NAC.	nac	113-116	forkhead box P3	Homo sapiens	59-64
34104541-6	2021	The density of CD8+ cells was decreased and the density of FoxP3+ cells and CD20+ cells was increased in PT post-NAC.	nac	113-116	keratin 20	Homo sapiens	76-80
35489467-6	2022	Among those oximes, trimedoxime seems to be the most promising, since it showed lower values of energy in the MM-PBSA calculations, a higher stability inside the catalytic anionic center (CAS) of HssAChE, and was able to adopt a position closer to the NAC that could enable the reactivation mechanism.	nac	252-255	acetylcholinesterase (Cartwright blood group)	Homo sapiens	196-203
34258022-1	2021	Aim: To investigate the prognostic role of neutrophil percentage-to-albumin ratio (NPAR) in muscle-invasive bladder cancer (MIBC) patients treated with neoadjuvant chemotherapy (NAC) and radical cystectomy (RC).	nac	178-181	albumin	Homo sapiens	68-75
34094037-12	2021	Conclusion: Our findings hypothesize that NAC with doxorubicin may potentiate antitumor immunity not merely by recruitment of TILs, but via down-regulation of PD-1 and TIM-3 checkpoints.	nac	42-45	programmed cell death 1	Mus musculus	159-163
34094037-12	2021	Conclusion: Our findings hypothesize that NAC with doxorubicin may potentiate antitumor immunity not merely by recruitment of TILs, but via down-regulation of PD-1 and TIM-3 checkpoints.	nac	42-45	hepatitis A virus cellular receptor 2	Mus musculus	168-173
34094037-13	2021	Carboplatin-containing NAC may suppress PD-1 as well.	nac	23-26	programmed cell death 1	Mus musculus	40-44
34092620-6	2021	The relation of PKM2 expression and multi-drug resistance to NAC was compared.	nac	61-64	pyruvate kinase M1/2	Homo sapiens	16-20
34092620-11	2021	PKM2 was an independent prognostic predictor for surgical resected breast cancer and NAC patients.	nac	85-88	pyruvate kinase M1/2	Homo sapiens	0-4
34151842-6	2021	OBJECTIVE: Explore the predictive effect of LncRNA BCAR4 on the efficacy of NAC for LABC in three different evaluation systems.	nac	76-79	breast cancer anti-estrogen resistance 4	Homo sapiens	51-56
34151842-12	2021	Among the three evaluation systems, only in the RECIST 1.1 evaluation system LncRNA BCAR4 has a predictive effect on NAC for LABC.	nac	117-120	breast cancer anti-estrogen resistance 4	Homo sapiens	84-89
34151842-14	2021	CONCLUSION: LncRNA BCAR4 is highly expressed in LABC tissues and may be an effective marker for predicting the efficacy of NAC for LABC.	nac	123-126	breast cancer anti-estrogen resistance 4	Homo sapiens	19-24
35579777-1	2022	Patients with hormone receptor (HR)-positive tumors breast cancer usually experience a relatively low pathological complete response (pCR) to neoadjuvant chemotherapy (NAC).	nac	168-171	nuclear receptor subfamily 4 group A member 1	Homo sapiens	14-30
35543228-3	2022	The study firstly identified XBP1 who received neoadjuvant chemotherapy (NAC) from GSE25055 and GSE24460.	nac	73-76	X-box binding protein 1	Homo sapiens	29-33
35543228-12	2022	Finally, XBP1 expression was higher in chemo-resistive than chemo-sensitive cases, it had a predictive value and could independently predict chemotherapy response in BC patients receiving NAC.	nac	188-191	X-box binding protein 1	Homo sapiens	9-13
35449473-7	2022	Significant increases in NAC were found in all strata (p < .0001) with more substantial increases in HER2 + disease and TNBC compared to HR + /HER2- disease.	nac	25-28	erb-b2 receptor tyrosine kinase 2	Homo sapiens	143-147
35449473-10	2022	NAC was received by most patients with stage III HER2 + disease or TNBC in more recent years and was more common among younger elderly women and those in stage III.	nac	0-3	erb-b2 receptor tyrosine kinase 2	Homo sapiens	49-53
35578919-8	2022	CONCLUSIONS: Black race was associated with significantly inferior DRFS in ER+ localized breast cancer treated with AC or NAC, but not in ER- disease.	nac	122-125	epiregulin	Homo sapiens	75-77
35578919-9	2022	In the NAC group, racial disparity was also observed in patients with residual ER+ breast cancer at surgery, but not in those who had pCR.	nac	7-10	epiregulin	Homo sapiens	79-81
35569077-4	2022	METHODS: With institutional review board approval, we queried our institutional database to identify all patients with primary ER+/HER2- biopsy-proven cN+ breast cancer treated with NAC followed by surgery from January 2012 to December 2021.	nac	182-185	estrogen receptor 1	Homo sapiens	127-129
35569077-4	2022	METHODS: With institutional review board approval, we queried our institutional database to identify all patients with primary ER+/HER2- biopsy-proven cN+ breast cancer treated with NAC followed by surgery from January 2012 to December 2021.	nac	182-185	erb-b2 receptor tyrosine kinase 2	Homo sapiens	131-135
35569077-15	2022	CONCLUSIONS: In ER+/HER2- breast cancer, nodal downstaging with NAC is associated with age (< 50 years) and Ki67 (>= 20%).	nac	64-67	estrogen receptor 1	Homo sapiens	16-18
35569077-15	2022	CONCLUSIONS: In ER+/HER2- breast cancer, nodal downstaging with NAC is associated with age (< 50 years) and Ki67 (>= 20%).	nac	64-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	20-24
35634245-8	2022	The NAC correctly classified the functional consequences of two novel CYLD missense mutations.	nac	4-7	CYLD lysine 63 deubiquitinase	Homo sapiens	70-74
35579777-1	2022	Patients with hormone receptor (HR)-positive tumors breast cancer usually experience a relatively low pathological complete response (pCR) to neoadjuvant chemotherapy (NAC).	nac	168-171	nuclear receptor subfamily 4 group A member 1	Homo sapiens	32-34
35565437-4	2022	Immunohistochemistry showed significantly increased PD-L1 levels and TIL levels after NAC.	nac	86-89	CD274 molecule	Homo sapiens	52-57
35614971-9	2022	There was a higher proportion of alpha1 + cells in the NAc-projectors compared to CeA-projectors in the BLA.	nac	55-58	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	33-39
35552411-12	2022	Single-agent NAC with HER2-directed therapy in selected patients may provide excellent outcome with reduced toxicity, while allowing escalated therapy in the adjuvant setting for patients with residual disease.	nac	13-16	erb-b2 receptor tyrosine kinase 2	Homo sapiens	22-26
35547600-2	2022	The present study aimed to evaluate the predictive ability of the fibrinogen-albumin ratio index (FARI) to the efficacy of neoadjuvant chemotherapy (NAC) for osteosarcoma.	nac	149-152	fibrinogen beta chain	Homo sapiens	66-76
35547600-2	2022	The present study aimed to evaluate the predictive ability of the fibrinogen-albumin ratio index (FARI) to the efficacy of neoadjuvant chemotherapy (NAC) for osteosarcoma.	nac	149-152	albumin	Homo sapiens	77-84
35547600-10	2022	ROC analysis showed that both FARI before NAC (preFARI; AUC = 0.594, p = 0.032) and the change in FARI before and after NAC (dfFARI = preFARI-postFARI; AUC = 0.652, p = 0.001) exhibited more favorable predictive ability than ALP and other inflammation markers.	nac	120-123	alkaline phosphatase, placental	Homo sapiens	225-228
35487246-8	2022	Our results reveal the presence of a positively charged amino acid cluster in the MTS of select mitochondrial precursors, such as Oxa1 and Fum1, which are crucial for their recognition by alphabeta"-NAC.	nac	199-202	membrane insertase OXA1	Saccharomyces cerevisiae S288C	130-134
35365420-8	2022	CONCLUSIONS: A negative prognostic value of high ADAM12 expression was observed in patients with PDAC treated with surgical resection, which was enhanced in patients treated with NAC, including nab-PTX.	nac	179-182	ADAM metallopeptidase domain 12	Homo sapiens	49-55
35504250-7	2022	In pre-NAC specimens, high CD68+/CD163+ infiltration into TN was an unfavorable prognostic factor.	nac	7-10	CD68 molecule	Homo sapiens	27-31
35504250-9	2022	The density of CD68+/CD163+ TAMs was increased in PT post-NAC, while the density of MARCO+ TAMs was decreased.	nac	58-61	CD68 molecule	Homo sapiens	15-19
35504250-9	2022	The density of CD68+/CD163+ TAMs was increased in PT post-NAC, while the density of MARCO+ TAMs was decreased.	nac	58-61	CD163 molecule	Homo sapiens	21-26
35487246-8	2022	Our results reveal the presence of a positively charged amino acid cluster in the MTS of select mitochondrial precursors, such as Oxa1 and Fum1, which are crucial for their recognition by alphabeta"-NAC.	nac	199-202	fumarase FUM1	Saccharomyces cerevisiae S288C	139-143
35438346-11	2022	A detailed assessment of the CD8/eTreg ratio for each patient who underwent NAC revealed that high CD8/eTreg ratio showed a significantly higher pCR rate compared to patients with a low CD8/FOXP3 ratio (39.6% vs 13.3, P < 0.05) in triple negative subtype patients with stromal TILs < 50%.	nac	76-79	CD8a molecule	Homo sapiens	29-32
35515127-18	2022	Conclusions: Clinical T stage, clinical N stage and tumor expression of ALDH3A2 were potential markers for predicting tumor recurrence in the pCR patients after NAC.	nac	161-164	aldehyde dehydrogenase 3 family member A2	Homo sapiens	72-79
35438346-11	2022	A detailed assessment of the CD8/eTreg ratio for each patient who underwent NAC revealed that high CD8/eTreg ratio showed a significantly higher pCR rate compared to patients with a low CD8/FOXP3 ratio (39.6% vs 13.3, P < 0.05) in triple negative subtype patients with stromal TILs < 50%.	nac	76-79	CD8a molecule	Homo sapiens	99-102
35503437-10	2022	This study suggested that patients with ER-negative, pre-NAC cT3 or T4 breast cancer who had achieved a pCR after NAC tended to have a worse prognosis.	nac	57-60	cancer antigen 1	Homo sapiens	61-64
35480699-15	2021	Together, these findings indicate that upregulated PI3K-AKT pathway serves as a potential indicator of lack of response to NAC in stage II/III BC patients, and other effective therapeutic options are urgently needed for those resistant patients.	nac	123-126	AKT serine/threonine kinase 1	Homo sapiens	56-59
35503437-10	2022	This study suggested that patients with ER-negative, pre-NAC cT3 or T4 breast cancer who had achieved a pCR after NAC tended to have a worse prognosis.	nac	114-117	estrogen receptor 1	Homo sapiens	40-42
35503437-10	2022	This study suggested that patients with ER-negative, pre-NAC cT3 or T4 breast cancer who had achieved a pCR after NAC tended to have a worse prognosis.	nac	114-117	cancer antigen 1	Homo sapiens	61-64
35119530-7	2022	RESULTS: Three of 16 patients with early TN ILC and 7/33 with early HER2+ ILC received NAC with pCR rates of 0/3 and 3/5 patients who underwent surgery, respectively.	nac	87-90	erb-b2 receptor tyrosine kinase 2	Homo sapiens	68-72
35445177-10	2022	Conclusion: These results suggest there is a need for reassessment of HR and HER-2 status in surgical samples from patients following NAC, and that NAC-induced changes in the HR state may be used as a prognostic factor.	nac	148-151	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-82
35451408-10	2022	DISCUSSION: This study will be the first RCT to evaluate the efficacy of Yanghe decoction combined with NAC in treating breast cancer patients, and elucidate the antitumor mechanism via the PI3K/Akt/NF-kappaB pathway-mediated immune-inflammation microenvironment.	nac	104-107	nuclear factor kappa B subunit 1	Homo sapiens	199-208
35319017-1	2022	The addition of pertuzumab (P) to trastuzumab (H) and neoadjuvant chemotherapy (NAC) has decreased the risk of distant recurrence in early stage HER2-positive breast cancer.	nac	80-83	erb-b2 receptor tyrosine kinase 2	Homo sapiens	145-149
35433455-7	2022	CellMinor analysis was employed to explore the relationship between CD4 mRNA expression and the reaction of tumor cells to NAC drugs.	nac	123-126	CD4 molecule	Homo sapiens	68-71
35433455-11	2022	The absolute numbers of CD4+ and CD8+ TIL infiltration in tumors in the NAC non-effectual group were significantly lower than those in the effectual group.	nac	72-75	CD4 molecule	Homo sapiens	24-27
35433455-11	2022	The absolute numbers of CD4+ and CD8+ TIL infiltration in tumors in the NAC non-effectual group were significantly lower than those in the effectual group.	nac	72-75	CD8a molecule	Homo sapiens	33-36
35433455-13	2022	NAC effectual-related signature bacteria were proportional to these patients" CD4+ T lymphocyte counts in peripheral blood and tumors (p"s < 0.05).	nac	0-3	CD4 molecule	Homo sapiens	78-81
35433455-14	2022	CellMinor analysis showed that the CD4 mRNA expression level dramatically climbed with increased sensitivity of tumor cells to NAC drugs such as cyclophosphamide, cisplatin, and carboplatin (p"s < 0.05).	nac	127-130	CD4 molecule	Homo sapiens	35-38
35433455-16	2022	The modulation of the gut microbiota on host CD4+ T lymphocytes may be one critical mechanism underlying chemosensitivity and NAC pathologic response.	nac	126-129	CD4 molecule	Homo sapiens	45-48
35328162-6	2022	Our results indicate that lamin B1 mean positive expression was 93% in normal breast epithelium and 88% in malignant breast cells, but significantly decreased (mean: 55%, p < 0.001) in malignant breast tissue after exposure to NAC, suggestive of senescence induction.	nac	227-230	lamin B1	Homo sapiens	26-34
35361730-5	2022	RESULTS: Infiltration of CD68+ macrophages in residual tumors after NAC was significantly decreased compared with treatment-naive GC patients, while no significant difference observed with respect to other immune markers.	nac	68-71	CD68 molecule	Homo sapiens	25-29
35361730-6	2022	In residual tumors, post-NAC CD8 +T cells and CD68+ macrophages levels were significantly associated with chemotherapy response.	nac	25-28	CD8a molecule	Homo sapiens	29-32
35361730-7	2022	Post-NAC CD8+ T cell levels remained as an independent predictor for favorable prognosis.	nac	5-8	CD8a molecule	Homo sapiens	9-12
35361730-8	2022	Furthermore, when comparing the paired samples before and after NAC from 30 cases of stage II/III GC patients, we found FOXP3+ regulatory T cells proportion significantly decreased after chemotherapy.	nac	64-67	forkhead box P3	Homo sapiens	120-125
35220235-6	2022	RESULTS: The disease-free survival (DFS) period after NAC for the high-FF-TIL group was found to be significantly longer than that for the low-FF-TIL group for all cases (p<0.001) and for all subtypes of triple-negative breast cancer (TNBC) (p=0.001), human epidermal growth factor receptor 2-enriched breast cancer (HER2BC) (p=0.010), and hormone receptor-positive breast cancer (HRBC) (p=0.003).	nac	54-57	erb-b2 receptor tyrosine kinase 2	Homo sapiens	258-292
35220235-6	2022	RESULTS: The disease-free survival (DFS) period after NAC for the high-FF-TIL group was found to be significantly longer than that for the low-FF-TIL group for all cases (p<0.001) and for all subtypes of triple-negative breast cancer (TNBC) (p=0.001), human epidermal growth factor receptor 2-enriched breast cancer (HER2BC) (p=0.010), and hormone receptor-positive breast cancer (HRBC) (p=0.003).	nac	54-57	erb-b2 receptor tyrosine kinase 2	Homo sapiens	317-323
35220235-6	2022	RESULTS: The disease-free survival (DFS) period after NAC for the high-FF-TIL group was found to be significantly longer than that for the low-FF-TIL group for all cases (p<0.001) and for all subtypes of triple-negative breast cancer (TNBC) (p=0.001), human epidermal growth factor receptor 2-enriched breast cancer (HER2BC) (p=0.010), and hormone receptor-positive breast cancer (HRBC) (p=0.003).	nac	54-57	nuclear receptor subfamily 4 group A member 1	Homo sapiens	340-356
34985726-2	2022	The predictive or prognostic value of BRCAness in HER2-negative breast cancer patients who have received neoadjuvant chemotherapy (NAC) is not fully elucidated.	nac	131-134	erb-b2 receptor tyrosine kinase 2	Homo sapiens	50-54
34985726-10	2022	Furthermore, we found phenotype change between BRCA1-like and sporadic type through NAC in 19% of non-pCR patients.	nac	84-87	BRCA1 DNA repair associated	Homo sapiens	47-52
35207810-2	2022	The purpose of this meta-analysis was to assess the values of BRCA1/2 and homologous recombination deficiency (HRD) in the prediction of the pathological complete response (pCR) rates of patients with TNBC treated with platinum-based neoadjuvant chemotherapy (NAC).	nac	260-263	BRCA1 DNA repair associated	Homo sapiens	62-69
35205837-4	2022	This study aims to identify effective protein networks and biomarkers to predict response to NAC in HER2-positive BC patients through an exhaustive large-scale LC-MS/MS-based qualitative and quantitative proteomic profiling of serum samples from responders and non-responders.	nac	93-96	erb-b2 receptor tyrosine kinase 2	Homo sapiens	100-104
35205837-7	2022	Qualitative analysis confirmed that three proteins (AFM, SERPINA1, APOD) were correlated with NAC resistance.	nac	94-97	afamin	Homo sapiens	52-55
35205837-7	2022	Qualitative analysis confirmed that three proteins (AFM, SERPINA1, APOD) were correlated with NAC resistance.	nac	94-97	serpin family A member 1	Homo sapiens	57-65
35207810-6	2022	In 12 trials with BRCA status, 629 of 1266 (49.7%) patients with TNBC achieved pCR with platinum-based NAC, including 134 out of 222 (60.4%) BRCA1/2-mutated patients and 495 out of 1044 (47.4%) BRCA wildtype patients (OR, 1.62; 95% CI, 1.20-2.20).	nac	103-106	BRCA1 DNA repair associated	Homo sapiens	141-148
35205837-7	2022	Qualitative analysis confirmed that three proteins (AFM, SERPINA1, APOD) were correlated with NAC resistance.	nac	94-97	apolipoprotein D	Homo sapiens	67-71
35207810-9	2022	CONCLUSIONS: BRCA1/2-mutated and HRD-positive patients with TNBC could benefit from platinum-based NAC.	nac	99-102	BRCA1 DNA repair associated	Homo sapiens	13-20
35237501-11	2021	Quantitative immunohistology and confocal microscopy demonstrated that increased levels of CD163+ monocytes are recruited in the tumor after NAC.	nac	141-144	CD163 molecule	Homo sapiens	91-96
35237501-12	2021	The percentage of CD14lowCD16+ in the total monocyte population positively correlated with the response to NAC assessed by pCR: 8.3% patients with pCR versus 2.5% without pCR (p = 0.018).	nac	107-110	CD14 molecule	Homo sapiens	18-29
35237501-13	2021	Search for the specific monocyte surface markers correlating with NAC response evaluated by RECIST 1.1 revealed that patients with no response to NAC had a significantly lower amount of CD14lowCD16+HLA-DR+ cells compared to the patients with clinical response to NAC (55.12% vs. 84.62%, p = 0.005).	nac	66-69	CD14 molecule	Homo sapiens	186-190
35237501-17	2021	The most striking surface markers were CD163 for the presence of BC, and HLA-DR (CD14lowCD16+HLA-DR+) for the response to NAC.	nac	122-125	CD14 molecule	Homo sapiens	81-85
35198437-10	2022	With multivariate analysis, the RS1, RS2, Delta RS, and Ki-67 expression were independently associated with breast NAC response.	nac	115-118	retinoschisin 1	Homo sapiens	32-35
35204227-9	2022	In addition, treatment of TGEV-infected IPEC-J2 cells with the ROS inhibitors (NAC) significantly reduced the protein levels of p-P38MAPK, Fas, Bax, and Cleaved-caspase-3 and the percentage of apoptotic cells.	nac	79-82	Fas cell surface death receptor	Sus scrofa	139-142
35204227-9	2022	In addition, treatment of TGEV-infected IPEC-J2 cells with the ROS inhibitors (NAC) significantly reduced the protein levels of p-P38MAPK, Fas, Bax, and Cleaved-caspase-3 and the percentage of apoptotic cells.	nac	79-82	apoptosis regulator BAX	Sus scrofa	144-147
35198437-12	2022	The nomogram incorporating RS1, RS2, and Ki-67 expression showed better predictive ability for NAC response with an area under the curve (AUC) of 0.866 in validation cohorts than either the single RS1 (AUC 0.725) or RS2 (AUC 0.793) or Ki-67 (AUC 0.643).	nac	95-98	retinoschisin 1	Homo sapiens	27-30
35198437-12	2022	The nomogram incorporating RS1, RS2, and Ki-67 expression showed better predictive ability for NAC response with an area under the curve (AUC) of 0.866 in validation cohorts than either the single RS1 (AUC 0.725) or RS2 (AUC 0.793) or Ki-67 (AUC 0.643).	nac	95-98	retinoschisin 1	Homo sapiens	197-200
35109796-3	2022	METHODS: RBM3 protein expression level in tumour cells was assessed via immunohistochemistry in paired transurethral resection of the bladder (TURB) specimens, cystectomy specimens and lymph node metastases from a consecutive cohort of 145 patients, 65 of whom were treated with NAC.	nac	279-282	RNA binding motif protein 3	Homo sapiens	9-13
35113808-10	2022	NAC and BAY 11-7082 inhibited the VF-induced Kir6.1 upregulation.	nac	0-3	potassium inwardly-rectifying channel, subfamily J, member 8	Rattus norvegicus	45-51
35109796-4	2022	Kaplan-Meier and Cox regression analyses were applied to estimate the impact of RBM3 expression on time to recurrence (TTR), cancer-specific survival (CSS), and overall survival (OS) in strata according to NAC treatment.	nac	206-209	RNA binding motif protein 3	Homo sapiens	80-84
35109796-8	2022	Patients with high-tumour specific RBM3 expression treated with NAC had a significantly reduced risk of recurrence and a prolonged CSS and OS compared to NAC-untreated patients.	nac	64-67	RNA binding motif protein 3	Homo sapiens	35-39
35191764-8	2022	In addition, the NAC treatment significantly increased the expression levels of TGF-beta1, TGF-beta2, KL-6, and MMP-1.	nac	17-20	transforming growth factor, beta 1	Rattus norvegicus	80-89
35191764-8	2022	In addition, the NAC treatment significantly increased the expression levels of TGF-beta1, TGF-beta2, KL-6, and MMP-1.	nac	17-20	transforming growth factor, beta 2	Rattus norvegicus	91-100
35191764-8	2022	In addition, the NAC treatment significantly increased the expression levels of TGF-beta1, TGF-beta2, KL-6, and MMP-1.	nac	17-20	matrix metallopeptidase 1	Rattus norvegicus	112-117
35191764-12	2022	This study demonstrated that administered with NAC and MIX could improve TGF-beta1, TGF-beta2, and KL-6 in serum of hard metal lung disease in a rat model.	nac	47-50	transforming growth factor, beta 1	Rattus norvegicus	73-82
35191764-12	2022	This study demonstrated that administered with NAC and MIX could improve TGF-beta1, TGF-beta2, and KL-6 in serum of hard metal lung disease in a rat model.	nac	47-50	transforming growth factor, beta 2	Rattus norvegicus	84-93
35087749-1	2021	Background: Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) as neoadjuvant chemotherapy (NAC) for breast cancer remains controversial.	nac	96-99	albumin	Homo sapiens	25-32
34665867-5	2022	RNAseq and plant hormone analyses reveal that PPC2pro:SlTGA2.2-SRDX fruits are maintained in an immature stage as long as PPC2pro is active, through early modifications of plant hormonal signalling and down-regulation of MADS-RIN and NAC-NOR ripening regulators.	nac	234-237	phosphoenolpyruvate carboxylase	Solanum lycopersicum	122-126
35163064-5	2022	In the last few years, translational-based research approaches have identified several candidate biomarkers of NAC esponsiveness, such as ERCC2, ERBB2, or DNA damage response (DDR) gene alterations.	nac	111-114	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	138-143
35163064-5	2022	In the last few years, translational-based research approaches have identified several candidate biomarkers of NAC esponsiveness, such as ERCC2, ERBB2, or DNA damage response (DDR) gene alterations.	nac	111-114	erb-b2 receptor tyrosine kinase 2	Homo sapiens	145-150
35049705-8	2022	Multivariate analysis revealed a low skeletal muscle index/total adipose tissue index (SMI/TATI) ratio as an independent NAC ischemia risk factor.	nac	121-124	serine peptidase inhibitor Kazal type 1	Homo sapiens	91-95
35049705-9	2022	An increase in the SMI/TATI ratio by one decreased the incidence of NAC ischemia by 0.940-fold (p = 0.030).	nac	68-71	serine peptidase inhibitor Kazal type 1	Homo sapiens	23-27
35049705-10	2022	A low SMI/TATI ratio is a risk factor for postoperative NAC ischemia in patients undergoing RNSM with IBR for breast cancer.	nac	56-59	serine peptidase inhibitor Kazal type 1	Homo sapiens	10-14
35087749-3	2021	Methods: In this retrospective analysis, a total of 159 HER2-negative breast cancer patients who had undergone operation after NAC were consecutively analyzed from May 2016 to April 2018.	nac	127-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	56-60
35075949-7	2022	NAC application (an ROS scavenger) effectively decreased U-increased ROS content and NLRP3 expression and restored U-induced pyroptosis.	nac	0-3	NLR family, pyrin domain containing 3	Rattus norvegicus	85-90
35114682-3	2022	METHODS: HER2-positive primary breast cancer patients treated using NAC containing trastuzumab were enrolled between September 2006 and July 2018 at Osaka Breast Clinic.	nac	68-71	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-13
35225058-2	2022	METHODS: PD-L1 expression was evaluated using immunohistochemistry in post-operative, post-NAC samples of 60 patients (n = 60) diagnosed with breast invasive ductal carcinoma with incomplete PR to NAC, including 31 matched pre-NAC and post-NAC samples (n = 31).	nac	91-94	CD274 molecule	Homo sapiens	9-14
35225058-2	2022	METHODS: PD-L1 expression was evaluated using immunohistochemistry in post-operative, post-NAC samples of 60 patients (n = 60) diagnosed with breast invasive ductal carcinoma with incomplete PR to NAC, including 31 matched pre-NAC and post-NAC samples (n = 31).	nac	227-230	CD274 molecule	Homo sapiens	9-14
35225058-2	2022	METHODS: PD-L1 expression was evaluated using immunohistochemistry in post-operative, post-NAC samples of 60 patients (n = 60) diagnosed with breast invasive ductal carcinoma with incomplete PR to NAC, including 31 matched pre-NAC and post-NAC samples (n = 31).	nac	240-243	CD274 molecule	Homo sapiens	9-14
35225058-4	2022	RESULTS: In the post-operative, post-NAC samples (n = 60), positive expression rate of PD-L1 was observed in 18.3% (11/60) of cases by TPS, 31.7% (19/60) by ICS, and 25% (15/60) by CPS.	nac	37-40	CD274 molecule	Homo sapiens	87-92
35225058-5	2022	In matched samples, positive expression rate of PD-L1 was observed in 19.3% (6/31) of patients by TPS, 51.6% (16/31) by ICS, and 19.3% (6/31) by CPS in pre-NAC specimens, while it was observed in 22.6% (7/31) of matched post-NAC samples by TPS, 22.6% (7/31) by ICS, and 19.3% (6/31) by CPS.	nac	156-159	CD274 molecule	Homo sapiens	48-53
35225058-5	2022	In matched samples, positive expression rate of PD-L1 was observed in 19.3% (6/31) of patients by TPS, 51.6% (16/31) by ICS, and 19.3% (6/31) by CPS in pre-NAC specimens, while it was observed in 22.6% (7/31) of matched post-NAC samples by TPS, 22.6% (7/31) by ICS, and 19.3% (6/31) by CPS.	nac	225-228	CD274 molecule	Homo sapiens	48-53
35225058-6	2022	In the matched samples, there was a significant decrease in PD-L1 immunoexpression using ICS in post-NAC specimens (McNemar"s, p = 0.020), while no significant differences were found using TPS and CPS between pre- and post-NAC samples (p = 1.000, p = 0.617; respectively).	nac	101-104	CD274 molecule	Homo sapiens	60-65
35225058-6	2022	In the matched samples, there was a significant decrease in PD-L1 immunoexpression using ICS in post-NAC specimens (McNemar"s, p = 0.020), while no significant differences were found using TPS and CPS between pre- and post-NAC samples (p = 1.000, p = 0.617; respectively).	nac	223-226	CD274 molecule	Homo sapiens	60-65
35225058-10	2022	CONCLUSION: Our findings indicate that PD-L1 protein expression in infiltrating immune cells was significantly reduced in breast tumors that developed incomplete PR following the exposure to NAC.	nac	191-194	CD274 molecule	Homo sapiens	39-44
2670200-6	1989	The effect of GM-CSF appeared to be specific for monocytes within the circulating peripheral blood cells because nonadherent cells (NAC) and granulocytes, which are normally resistant to LAK-mediated lysis, did not become susceptible after treatment with GM-CSF.	nac	132-135	colony stimulating factor 2	Homo sapiens	14-20
34887371-1	2022	OBJECTIVES: An earlier study demonstrated comparable lesion detection between attenuation-corrected (AC) and nonattenuation-corrected (NAC) 18F-sodium fluoride (NaF) PET images, which is relevant for computed tomography (CT) radiation dose-saving.	nac	135-138	C-X-C motif chemokine ligand 8	Homo sapiens	161-164
34887371-3	2022	The aim was to compare lesion detection between AC and NAC NaF PET images on modern PET-CT systems.	nac	55-58	C-X-C motif chemokine ligand 8	Homo sapiens	59-62
3741137-2	1986	Because PCBD-NAC causes selective necrosis to the pars recta of the proximal tubule, and is an organic anion it might be expected to be transported by the renal organic anion transport system.	nac	13-16	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	8-12
3067255-7	1988	Only the rad6 mutant exhibited an irradiation-dose dependent NAC-uptake after UV-C irradiation.	nac	61-64	E2 ubiquitin-conjugating protein RAD6	Saccharomyces cerevisiae S288C	9-13
3741137-4	1986	14C-PCBD-NAC uptake was temperature dependent and reduced by the metabolic inhibitors cyanide and iodoacetate.	nac	9-12	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	4-8
3741137-5	1986	Probenecid and sulphinpyrazone, specific competitive inhibitors of the anion transport system, and dinitrophenol, a metabolic inhibitor as well as a competitive inhibitor of anion transport, reduced PCBD-NAC transport.	nac	204-207	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	199-203
3741137-7	1986	These data are consistent with the transport of PCBD-NAC by the renal organic anion secretory system.	nac	53-56	pterin-4 alpha-carbinolamine dehydratase 1	Rattus norvegicus	48-52
3865202-4	1985	After cleavage from the protein, oligosaccharides containing the sequence GalNAc(beta 1-4)Glc-NAc(beta 1-2)Man alpha were sulfated by enzymes in pituitary membranes.	nac	77-80	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	81-89
3865202-4	1985	After cleavage from the protein, oligosaccharides containing the sequence GalNAc(beta 1-4)Glc-NAc(beta 1-2)Man alpha were sulfated by enzymes in pituitary membranes.	nac	77-80	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	98-106
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	nac	47-50	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	35-41
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	nac	47-50	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-59
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	nac	47-50	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-57
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	nac	47-50	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	96-104
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	nac	47-50	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-57
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	nac	47-50	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-57
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	nac	92-95	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	35-41
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	nac	92-95	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-59
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	nac	92-95	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-57
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	nac	92-95	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-57
6437450-9	1984	170, 343-349): NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)Glc-NAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)]Glc-NAc(beta 1-4) [Fuc(alpha 1-6)]GlcNAc.	nac	92-95	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	51-57
6429243-6	1984	Enhancement of NK activity of SF NAC by both poly I:C and IL 2 was not dependent on AC.	nac	33-36	interleukin 2	Homo sapiens	58-62
7060557-4	1982	Glycopeptide D: NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)Glc-NAc(beta 1-4)[Fuc(alpha 1-6)]GlcNAc(beta 1-)Asn.	nac	48-51	tubulin beta 3 class III	Homo sapiens	80-88
7060557-4	1982	Glycopeptide D: NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)Glc-NAc(beta 1-4)[Fuc(alpha 1-6)]GlcNAc(beta 1-)Asn.	nac	48-51	adrenoceptor alpha 1D	Homo sapiens	109-118
6619126-10	1983	)[Gal(beta 1,3/4)Glc-NAc(beta 1,?)]	nac	21-24	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	6-12
6619126-10	1983	)[Gal(beta 1,3/4)Glc-NAc(beta 1,?)]	nac	21-24	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	25-31
7060557-4	1982	Glycopeptide D: NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)Glc-NAc(beta 1-4)[Fuc(alpha 1-6)]GlcNAc(beta 1-)Asn.	nac	48-51	immunoglobulin binding protein 1	Homo sapiens	22-31
7060557-4	1982	Glycopeptide D: NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)Glc-NAc(beta 1-4)[Fuc(alpha 1-6)]GlcNAc(beta 1-)Asn.	nac	48-51	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	36-44
7060557-4	1982	Glycopeptide D: NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)Glc-NAc(beta 1-4)[Fuc(alpha 1-6)]GlcNAc(beta 1-)Asn.	nac	48-51	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	52-60
7060557-4	1982	Glycopeptide D: NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)Glc-NAc(beta 1-4)[Fuc(alpha 1-6)]GlcNAc(beta 1-)Asn.	nac	48-51	tubulin beta 3 class III	Homo sapiens	80-88
7060557-4	1982	Glycopeptide D: NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)Glc-NAc(beta 1-4)[Fuc(alpha 1-6)]GlcNAc(beta 1-)Asn.	nac	48-51	adrenoceptor alpha 1D	Homo sapiens	65-74
7060557-4	1982	Glycopeptide D: NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)Glc-NAc(beta 1-4)[Fuc(alpha 1-6)]GlcNAc(beta 1-)Asn.	nac	48-51	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	80-88
7060557-4	1982	Glycopeptide D: NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)Glc-NAc(beta 1-4)[Fuc(alpha 1-6)]GlcNAc(beta 1-)Asn.	nac	48-51	adrenoceptor alpha 1D	Homo sapiens	155-164
7060557-4	1982	Glycopeptide D: NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)Glc-NAc(beta 1-4)[Fuc(alpha 1-6)]GlcNAc(beta 1-)Asn.	nac	48-51	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	96-104
7060557-4	1982	Glycopeptide D: NeuAc(alpha 2-6)Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-3)[Gal(beta 1-4)GlcNAc(beta 1-2)Man(alpha 1-6)]Man(beta 1-4)Glc-NAc(beta 1-4)[Fuc(alpha 1-6)]GlcNAc(beta 1-)Asn.	nac	48-51	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	36-42
33403414-0	2021	Letter to the Editor: Sub-muscular Reconstruction After NAC Sparing Mastectomy-Direct to Implant Breast Reconstruction with Human ADM Versus Tissue Expander.	nac	56-59	adrenomedullin	Homo sapiens	130-133
33325610-9	2021	Co-administration of the ROS inhibitor NAC largely abolished the up-regulated p53 protein level, and rescued the suppressed viability and colony formation ability in butein-exposed U-2 OS cells.	nac	39-42	tumor protein p53	Homo sapiens	78-81
34032986-5	2021	METHODS: M2 macrophages were investigated on biopsy whole sections from 66 TNBCs treated with NAC by CD163 together with other immune checkpoint markers (PD1, PD-L1 and CD8) using a multi-color immunohistochemical multiplex assay.	nac	94-97	CD163 molecule	Homo sapiens	101-106
34032986-7	2021	CONCLUSIONS: Our data have demonstrated that the level of CD163-positive M2 macrophages was significantly higher in TNBC patients with incomplete response than patients with complete response, suggesting M2 macrophages" important role in predicting TNBC patients" response to NAC.	nac	276-279	CD163 molecule	Homo sapiens	58-63
34016892-7	2021	CONCLUSIONS: Serum carcinoembryonic antigen and C-reactive protein to albumin ratio are associated with Evans I disease in patients with PDAC who receive NAC-GS.	nac	154-157	C-reactive protein	Homo sapiens	48-66
34016892-7	2021	CONCLUSIONS: Serum carcinoembryonic antigen and C-reactive protein to albumin ratio are associated with Evans I disease in patients with PDAC who receive NAC-GS.	nac	154-157	albumin	Homo sapiens	70-77
33980202-9	2021	After adjusted for other clinicopathological factors in the multivariate logistic regression model, low Fib status was strongly associated with pCR to NAC (OR = 3.038, 95% CI 1.667-5.537, P <  0.001).	nac	151-154	fibrinogen beta chain	Homo sapiens	104-107
33980202-11	2021	CONCLUSIONS: This study demonstrates that low pre-treatment plasma Fib (Fib < 3.435 g/L) is an independent predictive factor for pCR to NAC in breast cancer patients.	nac	136-139	fibrinogen beta chain	Homo sapiens	67-70
33980202-11	2021	CONCLUSIONS: This study demonstrates that low pre-treatment plasma Fib (Fib < 3.435 g/L) is an independent predictive factor for pCR to NAC in breast cancer patients.	nac	136-139	fibrinogen beta chain	Homo sapiens	72-75
33980202-12	2021	Moreover, T3-featured breast cancer patients with lower Fib level exhibit better RFS outcomes after NAC compared with high Fib status.	nac	100-103	fibrinogen beta chain	Homo sapiens	56-59
33915655-8	2021	Negative PR and ER and positive HER2 status are related to the efficacy of pCR for breast cancer, and have guiding significance for the prognosis evaluation of NAC.	nac	160-163	progesterone receptor	Homo sapiens	9-11
33915655-8	2021	Negative PR and ER and positive HER2 status are related to the efficacy of pCR for breast cancer, and have guiding significance for the prognosis evaluation of NAC.	nac	160-163	estrogen receptor 1	Homo sapiens	16-18
33915655-8	2021	Negative PR and ER and positive HER2 status are related to the efficacy of pCR for breast cancer, and have guiding significance for the prognosis evaluation of NAC.	nac	160-163	erb-b2 receptor tyrosine kinase 2	Homo sapiens	32-36
33392839-2	2021	Optimal sequencing of treatment (NAC vs. surgery first) is less clear cut in stage I (T1N0) HER2 + BC, where information from surgical pathology could impact adjuvant treatment decisions.	nac	33-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	92-96
33392839-3	2021	Utilizing the NCDB, we evaluated the trend of NAC use compared to upfront surgery in patients with small HER2 + BC.	nac	46-49	erb-b2 receptor tyrosine kinase 2	Homo sapiens	105-109
33538993-10	2021	In 34 patients who received NAC, there was a small decrease in HER2-CN ratios between before and after NAC (P = 0.10), while there was an obvious decrease in HER2-ECD levels between before and after NAC (P < 0.001).	nac	28-31	erb-b2 receptor tyrosine kinase 2	Homo sapiens	63-67
33389510-6	2021	The rate of NAC peaked at 84.2% in the most recent year of analysis in all patients and was 100% in cT2 + patients eligible for NAC.	nac	12-15	cancer/testis antigen 2	Homo sapiens	100-103
33952501-8	2021	Similarly, pCR after NAC showed significantly better DFS (p=0.01), particularly for HER2-positive (p=0.003), triple-negative (p=0.019) and HER2-positive Luminal B profiles (p=0.019).	nac	21-24	erb-b2 receptor tyrosine kinase 2	Homo sapiens	84-88
33952501-8	2021	Similarly, pCR after NAC showed significantly better DFS (p=0.01), particularly for HER2-positive (p=0.003), triple-negative (p=0.019) and HER2-positive Luminal B profiles (p=0.019).	nac	21-24	erb-b2 receptor tyrosine kinase 2	Homo sapiens	139-143
33910135-3	2021	In this study, it is demonstrated that miR164 can regulate root growth and adventitious root generation of wheat under phenanthrene exposure by targeting NAC (NAM/ATAF/CUC) transcription factor.	nac	154-157	SH3 and cysteine rich domain 3	Homo sapiens	159-171
32656671-11	2021	CONCLUSION: Positive Ki-67 and PD-L1 expression in post-NAC radical cystectomy samples was associated with inferior OS and absence of tumor downstaging.	nac	56-59	CD274 molecule	Homo sapiens	31-36
32656671-12	2021	IHC on Ki-67 and PD-L1 would help to select patients for adjuvant therapy in post-NAC muscle-invasive bladder cancer.	nac	82-85	CD274 molecule	Homo sapiens	17-22
33943049-9	2021	Our results showed that the IHC signature of KRT5/6(+)/KRT20(-), as a combined marker of basal subtype, was the only covariate significantly associated with complete response to NAC (p=0.037).	nac	178-181	keratin 5	Homo sapiens	45-51
33943049-9	2021	Our results showed that the IHC signature of KRT5/6(+)/KRT20(-), as a combined marker of basal subtype, was the only covariate significantly associated with complete response to NAC (p=0.037).	nac	178-181	keratin 20	Homo sapiens	55-60
33908063-5	2021	SND2/3/4/5 regulated the expression of the same downstream target genes as do the secondary wall NAC master switches (SWNs) by binding to and activating the secondary wall NAC binding elements (SNBEs).	nac	97-100	NAC domain containing protein 73	Arabidopsis thaliana	0-10
33888424-10	2021	High levels of epithelial tumor markers (CA-125, CA 19-9) were also associated with worse OS and recurrence-free survival in the NAC setting.	nac	129-132	mucin 16, cell surface associated	Homo sapiens	41-47
33205221-0	2021	Invited Discussion on: "Sub-Muscular Reconstruction After NAC Sparing Mastectomy: Direct to Implant Based Reconstruction with Human ADM Versus Tissue Expander".	nac	58-61	adrenomedullin	Homo sapiens	132-135
33917939-7	2021	In the smaller, NAC cohort, EPLIN expression was found to be significantly lower in tumour tissues than in paratumour tissues.	nac	16-19	LIM domain and actin binding 1	Homo sapiens	28-33
33917939-9	2021	Together, EPLIN appears to be a prognostic factor and may be associated with patient sensitivity to NAC.	nac	100-103	LIM domain and actin binding 1	Homo sapiens	10-15
33165710-3	2021	METHODS: We retrospectively assessed T1-4, cN1/2 patients who were submitted to NAC between 2010 and 2016.	nac	80-83	5'-nucleotidase, cytosolic IA	Homo sapiens	43-48
33667252-12	2021	Post-NAC expressions change of ER and PR (ER and/or PR) are correlated to DFS.	nac	5-8	epiregulin	Homo sapiens	31-33
33486639-2	2021	The tumor response to NAC can be classified as either a pathological partial response (pPR) or pathological complete response (pCR), defined as complete eradication of invasive tumor cells, with a pCR conferring a significantly lower risk of recurrence.	nac	22-25	PPR1	Homo sapiens	87-90
33598878-3	2021	We aimed to determine the role of HER2 protein expression in predicting NAC response and long-term outcome in two HER2-positive groups: IHC 3 + versus IHC 2 + ISH amplified groups.	nac	72-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	34-38
33841459-0	2021	NAC Candidate Gene Marker for bgm-1 and Interaction With QTL for Resistance to Bean Golden Yellow Mosaic Virus in Common Bean.	nac	0-3	brain expressed associated with NEDD4 1	Homo sapiens	79-83
33545634-10	2021	Inhibition of the generation of peroxisomal ROS by treatment with NAC significantly suppressed pexophagy in HNRNPA1-deficient cells.	nac	66-69	heterogeneous nuclear ribonucleoprotein A1	Homo sapiens	108-115
33486641-4	2021	Thus, response information to NAC has become pivotal to guide adjuvant treatment recommendations, and has resulted in NAC being the preferred approach for most HER2-positive and triple-negative breast cancers.	nac	30-33	erb-b2 receptor tyrosine kinase 2	Homo sapiens	160-164
33486641-4	2021	Thus, response information to NAC has become pivotal to guide adjuvant treatment recommendations, and has resulted in NAC being the preferred approach for most HER2-positive and triple-negative breast cancers.	nac	118-121	erb-b2 receptor tyrosine kinase 2	Homo sapiens	160-164
33968680-12	2021	Compared to the other molecular subtypes, triple negative and HER2+/ER- subtypes are more likely to exhibit a good response to NAC.	nac	127-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	62-66
33869255-7	2021	It was found that the most common mutated genes were TP53 and PIK3CA in both samples before and after NAC, and no recurrent mutations were significantly associated with the shrinkage mode.	nac	102-105	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	62-68
33687613-6	2021	RESULTS: Among 69,312 cases of HR+/HER2- ILC, NAC use decreased slightly (from 4.7 to 4.2%, p = 0.007), while there was a small but significant increase in long-course NET (from 1.6 to 2.7%, p < 0.001).	nac	46-49	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-39
33667252-2	2021	We aimed to evaluate the changes in hormone (estrogen and progesterone) receptor (HR) and human epidermal growth factor receptor 2 (HER2) status post-NAC and their correlation with survival.	nac	150-153	erb-b2 receptor tyrosine kinase 2	Homo sapiens	96-130
33667252-11	2021	CONCLUSIONS: Patients with LABC have significant changes in the ER and PR receptor status following NAC.	nac	100-103	epiregulin	Homo sapiens	64-66
33667252-12	2021	Post-NAC expressions change of ER and PR (ER and/or PR) are correlated to DFS.	nac	5-8	epiregulin	Homo sapiens	42-44
33674443-4	2021	We quantified the expression of CD163, a crucial marker of TAM, in pre-therapeutic biopsy and surgically resected ESCC specimens from patients who received NAC (n=33) or did not receive NAC (n=12).	nac	156-159	CD163 molecule	Homo sapiens	32-37
33674443-5	2021	We found that NAC dramatically increased the expression of CD163 on TAMs in ESCC.	nac	14-17	CD163 molecule	Homo sapiens	59-64
33674443-7	2021	Interestingly, NAC significantly up-regulated the expression of IL-34 but not CSF-1 on tumor cells, and the frequencies of CD163+ TAMs were significantly correlated with IL-34 expression in ESCC after NAC.	nac	15-18	interleukin 34	Homo sapiens	64-69
33674443-8	2021	The expression of IL-34 in NAC-nonresponsive patients was significantly higher than that in NAC-responsive patients, and patients with IL-34-high ESCC exhibited worse prognosis as compared with patients with IL-34-low ESCC.	nac	27-30	interleukin 34	Homo sapiens	18-23
33674443-11	2021	These data suggest that IL-34 expression by NAC shifts the TME toward CD163+ TAMs-rich immunosuppressive and chemo-insensitive microenvironment in ESCC.	nac	44-47	interleukin 34	Homo sapiens	24-29
33674443-11	2021	These data suggest that IL-34 expression by NAC shifts the TME toward CD163+ TAMs-rich immunosuppressive and chemo-insensitive microenvironment in ESCC.	nac	44-47	CD163 molecule	Homo sapiens	70-75
33602886-8	2021	ET-1-increased Src expression was also inhibited by NAC under normoxia.	nac	52-55	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	15-18
32959140-3	2021	METHODS: Patients with cT1-T3N0 and pN0 disease treated with NAC who had residual disease in the breast were identified from a prospective database.	nac	61-64	cardiotrophin 1	Homo sapiens	23-26
32896105-8	2021	The OS benefit of NAC was observed even in patients with localized (cT2 or lower) disease (p = 0.019).	nac	18-21	cancer/testis antigen 2	Homo sapiens	68-71
33738251-3	2021	Materials and Methods: The present study examined the predictive role of Linc00665 expression in pCR after NAC using both univariate and multivariate logistic regression analyses.	nac	107-110	long intergenic non-protein coding RNA 665	Homo sapiens	73-82
33738251-11	2021	Conclusion: Linc00665 may be a potential novel predictive biomarker for breast cancer in NAC, especially for HR-positive/HER2-negative patients.	nac	89-92	long intergenic non-protein coding RNA 665	Homo sapiens	12-21
33854889-5	2021	SBH-PACT images breast cancer patients at three time points: before, during, and after NAC.	nac	87-90	RB binding protein 6, ubiquitin ligase	Homo sapiens	4-8
33602886-6	2021	Moreover, hypoxia-increased ANP secretion was evidently attenuated by the NOX4 antagonist GLX351322 (35.0 microM) and inhibitor of ROS N-Acetyl-D-cysteine (NAC, 15.0 mM), and hypoxia-increased production of ROS was blocked by GLX351322.	nac	156-159	natriuretic peptide A	Rattus norvegicus	28-31
33602886-8	2021	ET-1-increased Src expression was also inhibited by NAC under normoxia.	nac	52-55	endothelin 1	Rattus norvegicus	0-4
33854889-6	2021	The analysis of tumor size, blood vascular density, and irregularity in the distribution and morphology of the blood vessels on SBH-PACT accurately identifies response to NAC as confirmed by the histopathological diagnosis.	nac	171-174	RB binding protein 6, ubiquitin ligase	Homo sapiens	132-136
33599867-7	2021	CONCLUSION: High expression of immunohistochemically detected p53 was strongly and significantly associated with decreased OS and BCSS than low p53 expression, suggesting that p53 may be a powerful prognostic factor in HR-positive, HER2-negative breast cancer patients receiving NAC.	nac	279-282	tumor protein p53	Homo sapiens	62-65
32813202-11	2021	Among the 15 patients who presented as cN1, 14 (93%) converted to cN0 following NAC.	nac	80-83	5'-nucleotidase, cytosolic IA	Homo sapiens	39-42
33670162-6	2021	PD-L1-TC were significantly associated with a higher residual cancer burden (p = 0.035) and aggressive post-NAC tumor characteristics, whereas PD-L1-IC were not.	nac	108-111	CD274 molecule	Homo sapiens	0-5
33670162-8	2021	A small subset of TNBC patients displaying PD-L1 expression in the context of an extensive post-NAC tumor burden could benefit from ICI treatment after standard NAC.	nac	96-99	CD274 molecule	Homo sapiens	43-48
33670162-8	2021	A small subset of TNBC patients displaying PD-L1 expression in the context of an extensive post-NAC tumor burden could benefit from ICI treatment after standard NAC.	nac	161-164	CD274 molecule	Homo sapiens	43-48
33613258-10	2021	Enhanced DA signaling to the NAc in ob/ob mice, or in OX-A-injected wt mice, was accompanied by beta-arrestin2-mediated desensitization of dopamine D2 receptor (D2R) in a manner prevented by SB-334867 or the D2R antagonist L741 (1.5 mg/Kg, i.p.).	nac	29-32	leptin	Mus musculus	36-38
33613258-10	2021	Enhanced DA signaling to the NAc in ob/ob mice, or in OX-A-injected wt mice, was accompanied by beta-arrestin2-mediated desensitization of dopamine D2 receptor (D2R) in a manner prevented by SB-334867 or the D2R antagonist L741 (1.5 mg/Kg, i.p.).	nac	29-32	leptin	Mus musculus	39-41
33613258-10	2021	Enhanced DA signaling to the NAc in ob/ob mice, or in OX-A-injected wt mice, was accompanied by beta-arrestin2-mediated desensitization of dopamine D2 receptor (D2R) in a manner prevented by SB-334867 or the D2R antagonist L741 (1.5 mg/Kg, i.p.).	nac	29-32	arrestin, beta 2	Mus musculus	96-110
33517316-7	2021	CONCLUSION: Maintaining the RDI of NAC is crucial for achieving the survival benefit in selected patients with HER2-negative BC.	nac	35-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	111-115
33614999-3	2021	A previous study has shown that miR-301a was associated with invasion and metastasis in breast cancer, and was found to be involved in endocrine therapy resistance; however, evidence regarding the correlation between miR-301a expression and NAC efficacy remains scarce.	nac	241-244	microRNA 301a	Homo sapiens	32-40
33614999-3	2021	A previous study has shown that miR-301a was associated with invasion and metastasis in breast cancer, and was found to be involved in endocrine therapy resistance; however, evidence regarding the correlation between miR-301a expression and NAC efficacy remains scarce.	nac	241-244	microRNA 301a	Homo sapiens	217-225
33614999-7	2021	Relevant clinicopathological data were collected, and the correlation between miR-301a expression and NAC efficacy was assessed.	nac	102-105	microRNA 301a	Homo sapiens	78-86
33613258-0	2021	Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice.	nac	39-42	hypocretin	Mus musculus	0-8
33552956-7	2020	Multivariate Cox regression analysis showed pCR, chemotherapy effect, ypT, ypN, histological grades, and post- NAC expression of CK5/6 significantly affected prognosis.	nac	111-114	keratin 5	Homo sapiens	129-134
33552268-7	2021	The present study investigated the association between PRMT1 expression and the efficacy of NAC in locally advanced cervical cancer.	nac	92-95	protein arginine methyltransferase 1	Homo sapiens	55-60
33552268-11	2021	The results demonstrated that the NAC effective group had significantly lower weighted PRMT1 scores than the NAC ineffective group (P=0.030).	nac	34-37	protein arginine methyltransferase 1	Homo sapiens	87-92
33552268-12	2021	In addition, lower tumor expression levels of PRMT1 were significantly associated with increased sensitivity to NAC (P=0.033).	nac	112-115	protein arginine methyltransferase 1	Homo sapiens	46-51
33552268-14	2021	The present study suggested that PRMT1 expression has potential as a predictive marker of the efficacy of NAC in patients with locally advanced cervical cancer.	nac	106-109	protein arginine methyltransferase 1	Homo sapiens	33-38
33503182-2	2021	METHODS: Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to evaluate the miRNA-195 expression in tumor tissues from a cohort of female breast cancer patients undergoing NAC.	nac	201-204	microRNA 195	Homo sapiens	105-114
33503182-6	2021	This was more pronounced in luminal and triple-negative patients, and patient"s response to NAC was correlated with an increase in miRNA-195 expression.	nac	92-95	microRNA 195	Homo sapiens	131-140
33503182-7	2021	CONCLUSION: miRNA-195 is downregulated in the tumor tissues of Brazilian breast cancer patients regardless of NAC exposure; this reinforces its role as a tumor suppressor and a potential biomarker for chemotherapy response.	nac	110-113	microRNA 195	Homo sapiens	12-21
33345970-6	2021	Our results suggest that these events alter the transient alpha-synuclein intramolecular contacts, inducing a greater solvent exposure of its hydrophobic, aggregation-prone NAC domain, in full agreement with a recent experimental study on Ca2+ binding.	nac	173-176	synuclein alpha	Homo sapiens	58-73
33511630-6	2021	vGlut2 expression was higher in adolescents relative to adults within the PrL, but lower in the NAc.	nac	96-99	solute carrier family 17 member 6	Rattus norvegicus	0-6
33495450-10	2021	Our data revealed the lncRNA transactional portrait and highlighted a complex regulatory network orchestrated by MALAT1 in the context of TNBC resistance to NAC therapy.	nac	157-160	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	113-119
33498405-2	2021	The objective of this study was to compare the prognosis of HER2-positive BC patients treated with NAC to that of patients treated with adjuvant chemotherapy (AC).	nac	99-102	erb-b2 receptor tyrosine kinase 2	Homo sapiens	60-64
33498405-10	2021	CONCLUSION: In patients with HER2-positive BC, the NAC strategy is more beneficial than the AC strategy, particularly in cN-positive and postmenopausal patients.	nac	51-54	erb-b2 receptor tyrosine kinase 2	Homo sapiens	29-33
33498405-11	2021	NAC should be used as a first-line treatment for HER2-positive tumors.	nac	0-3	erb-b2 receptor tyrosine kinase 2	Homo sapiens	49-53
33552956-8	2020	The prognosis of CK5/6-positive patients after NAC was worse than that of CK5/6-negative patients (p=0.036).	nac	47-50	keratin 5	Homo sapiens	17-22
33462182-13	2021	The ROS scavenger N-acetyl-1-cysteine (NAC) abolished ATO-induced nuclear translocation of TFEB, as well as changes in key molecules of the AKT/mTOR signaling pathway and downstream autophagy.	nac	39-42	transcription factor EB	Mus musculus	91-95
33462182-13	2021	The ROS scavenger N-acetyl-1-cysteine (NAC) abolished ATO-induced nuclear translocation of TFEB, as well as changes in key molecules of the AKT/mTOR signaling pathway and downstream autophagy.	nac	39-42	mechanistic target of rapamycin kinase	Mus musculus	144-148
32725507-11	2020	MALAT1 showed more expression in ACCs than in NAC and ACA (p < 0.05).	nac	46-49	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-6
33441425-3	2021	We identified the intratumoral CXCR3 chemokine system (ligands and receptor splice variants) as a critical component for tumor eradication upon NAC in MIBC.	nac	144-147	C-X-C motif chemokine receptor 3	Homo sapiens	31-36
33441425-5	2021	In tumor biopsies of patients with MIBC accessed before treatment, CXCL11 abundance correlated with high numbers of tumor-infiltrating T cells and response to NAC.	nac	159-162	C-X-C motif chemokine ligand 11	Homo sapiens	67-73
33402494-1	2021	AIM: The aim of the present study was to explore the association between CD133 expression and postoperative relapses in patients with locally advanced rectal cancer (LARC) who received neoadjuvant chemotherapy (NAC).	nac	211-214	prominin 1	Homo sapiens	73-78
33402494-8	2021	CONCLUSION: CD133 expression may be a predictive biomarker for postoperative relapse in patients with LARC who received NAC before surgery.	nac	120-123	prominin 1	Homo sapiens	12-17
33439725-9	2021	RESULTS: MLR predictors of NAC response included: estrogen receptor (ER) status, human epidermal growth factor-2 (HER2) status, tumor size, and Nottingham grade.	nac	27-30	estrogen receptor 1	Homo sapiens	50-67
33439725-9	2021	RESULTS: MLR predictors of NAC response included: estrogen receptor (ER) status, human epidermal growth factor-2 (HER2) status, tumor size, and Nottingham grade.	nac	27-30	estrogen receptor 1	Homo sapiens	69-71
33439725-9	2021	RESULTS: MLR predictors of NAC response included: estrogen receptor (ER) status, human epidermal growth factor-2 (HER2) status, tumor size, and Nottingham grade.	nac	27-30	erb-b2 receptor tyrosine kinase 2	Homo sapiens	114-118
33328766-3	2020	The univariate comparisons of the differences in clinicopathological parameters between different HER2 protein expression groups, and the association between HER2 protein expression level and efficacy of NAC, were made using a X2 test or Mann-Whitney U-test.	nac	204-207	erb-b2 receptor tyrosine kinase 2	Homo sapiens	158-162
33328766-4	2020	Multivariate analyses of the differences in clinicopathological parameters between different HER2 protein expression groups, and the association between HER2 protein expression level and efficacy of NAC, were performed using logistic regression analysis.	nac	199-202	erb-b2 receptor tyrosine kinase 2	Homo sapiens	153-157
33328766-9	2020	The HER2 protein expression level might effectively predict the efficacy of NAC in patients with HER2-positive breast cancer (OR = 3.520, P = 0.003).	nac	76-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	4-8
33328766-11	2020	For example, hormone receptor, androgen receptor, cytokeratin5/6, and HER2 protein expression level may be used to predict the response to NAC in patients with HER2-positive breast cancer and may serve as a predictive factor for NAC efficacy.	nac	139-142	keratin 5	Homo sapiens	50-64
33328766-11	2020	For example, hormone receptor, androgen receptor, cytokeratin5/6, and HER2 protein expression level may be used to predict the response to NAC in patients with HER2-positive breast cancer and may serve as a predictive factor for NAC efficacy.	nac	139-142	erb-b2 receptor tyrosine kinase 2	Homo sapiens	70-74
33328766-11	2020	For example, hormone receptor, androgen receptor, cytokeratin5/6, and HER2 protein expression level may be used to predict the response to NAC in patients with HER2-positive breast cancer and may serve as a predictive factor for NAC efficacy.	nac	139-142	erb-b2 receptor tyrosine kinase 2	Homo sapiens	160-164
33328766-11	2020	For example, hormone receptor, androgen receptor, cytokeratin5/6, and HER2 protein expression level may be used to predict the response to NAC in patients with HER2-positive breast cancer and may serve as a predictive factor for NAC efficacy.	nac	229-232	erb-b2 receptor tyrosine kinase 2	Homo sapiens	70-74
33302444-3	2020	MATERIAL AND METHODS: Out of 1199 invasive BC patients treated with NAC between 2002 and 2012, we identified 267 patients tested for a germline BRCA pathogenic variant.	nac	68-71	BRCA1 DNA repair associated	Homo sapiens	144-148
33302444-12	2020	CONCLUSIONS: BRCA mutation status is associated with higher pCR rates and post-NAC TILs in patients with luminal BC.	nac	79-82	BRCA1 DNA repair associated	Homo sapiens	13-17
33302444-13	2020	BRCA-carriers with luminal BCs may represent a subset of patients deriving higher benefit from NAC.	nac	95-98	BRCA1 DNA repair associated	Homo sapiens	0-4
33268821-4	2020	Increases in TILs and CD8+ T cell proportions in response to NAC are independently associated with pathologic complete response.	nac	61-64	CD8a molecule	Homo sapiens	22-25
33633972-3	2021	We hypothesized that Th2 high tumors are highly proliferative, and thus more likely to respond to NAC in ER-positive breast cancer.	nac	98-101	estrogen receptor 1	Homo sapiens	105-107
33633972-11	2021	Th2 levels may be a biomarker in patient selection for NAC in ER-positive breast cancer.	nac	55-58	estrogen receptor 1	Homo sapiens	62-64
33455698-12	2021	CONCLUSIONS: Complete pathological response to NAC in breast cancer depends largely on the molecular phenotype of the tumor, regardless of the definition of pCR, with the highest response rates in the breast and axilla in the HER2 positive and triple negative phenotypes.	nac	47-50	erb-b2 receptor tyrosine kinase 2	Homo sapiens	226-230
33046356-11	2020	CONCLUSIONS: Our prospective study showed that a TC regimen as NAC achieved a high clinical response rate in stage II to III ER+/HER2- breast cancer.	nac	63-66	epiregulin	Homo sapiens	125-127
33046356-11	2020	CONCLUSIONS: Our prospective study showed that a TC regimen as NAC achieved a high clinical response rate in stage II to III ER+/HER2- breast cancer.	nac	63-66	erb-b2 receptor tyrosine kinase 2	Homo sapiens	129-133
33046356-12	2020	A TC regimen without anthracycline as NAC might be one of the options for patients with ER+/HER2- breast cancer without high-risk factors including progesterone receptor negativity.	nac	38-41	epiregulin	Homo sapiens	88-90
33198673-2	2020	In patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2) -negative breast cancer, the response to NAC is variable and mostly limited.	nac	138-141	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-89
33292226-13	2020	CONCLUSION: FABP7 is a potential favorable biomarker and predicts better response to NAC in breast cancer patients.	nac	85-88	fatty acid binding protein 7	Homo sapiens	12-17
33198673-2	2020	In patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2) -negative breast cancer, the response to NAC is variable and mostly limited.	nac	138-141	erb-b2 receptor tyrosine kinase 2	Homo sapiens	91-95
33198673-3	2020	This study was an investigation of the predictive relevance of parameters of 18F-FDG PET/CT for the pCR to NAC in patients with HR-positive, HER2-negative breast cancer.	nac	107-110	erb-b2 receptor tyrosine kinase 2	Homo sapiens	141-145
33198673-9	2020	CONCLUSION: The results of this study suggest that 18F-FDG PET/CT pSUVmax is a predictive factor for pCR of HR-positive, HER2-negative breast cancer to NAC.	nac	152-155	erb-b2 receptor tyrosine kinase 2	Homo sapiens	121-125
33152824-1	2020	Objective: To explore the relationship between the expression of human epidermal growth factor receptor 2 (HER2) in core needle biopsy (CNB) specimens before neoadjuvant chemotherapy (NAC) and post NAC Residual Cancer Burden (RCB) classification in breast cancer.	nac	184-187	erb-b2 receptor tyrosine kinase 2	Homo sapiens	71-105
33250924-9	2020	Our results suggest that circRNAs may be involved in regulating metabolism (i.e., carbohydrate, amino acid, lipid, and energy), signal transduction, and environmental adaptation-related pathways and that these circRNAs were predicted to regulate the expression of transcription factors, genes in signal transduction pathways, and genes related to the Ca2+ channel through targeting the corresponding proteins, such as WRKY, NAC, cytochrome P450, and calmodulin binding protein.	nac	424-427	cytochrome P450 85A3	Solanum lycopersicum	429-476
33152824-1	2020	Objective: To explore the relationship between the expression of human epidermal growth factor receptor 2 (HER2) in core needle biopsy (CNB) specimens before neoadjuvant chemotherapy (NAC) and post NAC Residual Cancer Burden (RCB) classification in breast cancer.	nac	184-187	erb-b2 receptor tyrosine kinase 2	Homo sapiens	107-111
33152824-9	2020	Statistical analysis found that the pre NAC HER2 expression was related to PCR and RCB classification after surgery (r1=-0.217,r2=-0.282;P<0.05).	nac	40-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	44-48
32740807-2	2020	With evolution of better targeted treatment regimens and awareness of improved outcomes for significant responders, use of NAC has expanded particularly for triple negative and HER2-positive (HER2+) breast cancer.	nac	123-126	erb-b2 receptor tyrosine kinase 2	Homo sapiens	177-181
32740807-2	2020	With evolution of better targeted treatment regimens and awareness of improved outcomes for significant responders, use of NAC has expanded particularly for triple negative and HER2-positive (HER2+) breast cancer.	nac	123-126	erb-b2 receptor tyrosine kinase 2	Homo sapiens	192-196
32740807-8	2020	Patients were more likely to receive NAC with cT3, cT4, and cN+ disease.	nac	37-40	cancer antigen 1	Homo sapiens	46-49
32740807-12	2020	CONCLUSIONS: NAC use among HR+ HER2- breast cancer patients has expanded over time and offers downstaging of disease for some patients, with pCR seen in only a small subset, but downstaging of the axilla in 21%.	nac	13-16	erb-b2 receptor tyrosine kinase 2	Homo sapiens	31-35
32529292-14	2020	Adoptive TIL therapy combined with PD-1 inhibitors might be promising for TNBC patients with residual tumors after NAC.	nac	115-118	programmed cell death 1	Homo sapiens	35-39
32934708-12	2020	CD3+ and CD4+ counts were associated with the pathological response to NAC (P=0.04).	nac	71-74	CD4 molecule	Homo sapiens	9-12
32680620-3	2020	METHODS: Retrospective chart review was performed of patients with Stage I-III HER2+ BC receiving NAC from 2007 to 2016.	nac	98-101	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-83
33039708-10	2020	INTERPRETATION: The machine learning models, including both clinical and radiomics MRI features, can be used to assess HER2 expression level and can predict pCR after NAC in HER2 overexpressing breast cancer patients.	nac	167-170	erb-b2 receptor tyrosine kinase 2	Homo sapiens	174-178
33116816-3	2020	Purpose: The aim of this study was to assess miRNA-21 expression in the tumor tissues of Brazilian patients with breast cancer who underwent NAC and its correlation with clinicopathological variables.	nac	141-144	microRNA 21	Homo sapiens	45-53
33149669-1	2020	Purpose: To identify MRI-based radiomics signature (Rad-score) as a biomarker of risk stratification for disease-free survival (DFS) in patients with HER2-positive invasive breast cancer treated with trastuzumab-based neoadjuvant chemotherapy (NAC) and establish a radiomics-clinicoradiologic-based nomogram that combines Rad-score, MRI findings, and clinicopathological variables for DFS estimation.	nac	244-247	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	52-55
33149669-11	2020	Conclusion: The Rad-score is an independent biomarker for the estimation of DFS in invasive HER2-positive breast cancer with NAC and the radiomics-clinicoradiologic-based nomogram improved individualized DFS estimation.	nac	125-128	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Homo sapiens	16-19
33149669-11	2020	Conclusion: The Rad-score is an independent biomarker for the estimation of DFS in invasive HER2-positive breast cancer with NAC and the radiomics-clinicoradiologic-based nomogram improved individualized DFS estimation.	nac	125-128	erb-b2 receptor tyrosine kinase 2	Homo sapiens	92-96
33154826-4	2020	The present study aimed to evaluate the association between pre-therapeutic serum GGT level and the efficacy, long-term survival, and adverse reactions of NAC and to investigate its role in predicting NAC sensitivity in patients with breast cancer.	nac	155-158	gamma-glutamyltransferase 1	Homo sapiens	82-85
33154826-10	2020	Results: Pre-therapeutic serum GGT levels were associated with pCR among breast cancer patients treated with NAC.	nac	109-112	gamma-glutamyltransferase 1	Homo sapiens	31-34
33154826-15	2020	Conclusion: Pre-therapeutic serum GGT level is an independent and novel biomarker for predicting the efficiency, prognosis, and adverse reactions to NAC in breast cancer patients.	nac	149-152	gamma-glutamyltransferase 1	Homo sapiens	34-37
32788068-9	2020	Additionally, overproduction of reactive oxidative stress (ROS) and subsequent activation of ROS/p38MAPK under CKD milieus contribute to these series of outcomes, as scavenging ROS with N-acety-l-cysteine (NAC) or inhibiting p38MAPK signal pathway with SB203580 could inhibit CKD-induced activation of ROS/p38MAPK, increased expression of lamin B1, abnormality of nuclear membrane structure and VSMCs senescence.	nac	206-209	lamin B1	Homo sapiens	339-347
33116816-4	2020	Patients and Methods: Utilizing qRT-PCR, miRNA-21 expression in tumor tissue was measured in a cohort of female patients with breast cancer who underwent NAC.	nac	154-157	microRNA 21	Homo sapiens	41-49
33116816-9	2020	Conclusion: miRNA-21 was upregulated in the tumor tissue of Brazilian patients with breast cancer regardless of NAC treatment, which reinforces its role as an "oncomiR" and a potential biomarker.	nac	112-115	microRNA 21	Homo sapiens	12-20
32457408-7	2020	However, using quantitative image analysis of CK19 immunohistochemistry, we found that the proportion of cancer cells that were intraductal was significantly different between the NAC and immediate surgery groups (median; 12.7% vs. 1.99%, p < 0.0001, Mann-Whitney U test).	nac	180-183	keratin 19	Homo sapiens	46-50
33224813-10	2020	In a subgroup of 129 patients with serum parathyroid hormone (PTH) levels available, we found that NAC patients exhibited significantly lower postoperative PTH concentrations than AC patients [median (interquartile range) 3 (1.9-7.8) vs. 6.9 (3.0-11) pg/mL; P=0.009].	nac	99-102	parathyroid hormone	Homo sapiens	41-60
33224813-10	2020	In a subgroup of 129 patients with serum parathyroid hormone (PTH) levels available, we found that NAC patients exhibited significantly lower postoperative PTH concentrations than AC patients [median (interquartile range) 3 (1.9-7.8) vs. 6.9 (3.0-11) pg/mL; P=0.009].	nac	99-102	parathyroid hormone	Homo sapiens	62-65
33224813-10	2020	In a subgroup of 129 patients with serum parathyroid hormone (PTH) levels available, we found that NAC patients exhibited significantly lower postoperative PTH concentrations than AC patients [median (interquartile range) 3 (1.9-7.8) vs. 6.9 (3.0-11) pg/mL; P=0.009].	nac	99-102	parathyroid hormone	Homo sapiens	156-159
32388585-8	2020	In post-NAC metastatic lesions, the frequency of immunoexpression of PD-L1 and IDO1 was increased compared with that in pre-NAC specimens.	nac	8-11	CD274 molecule	Homo sapiens	69-74
32388585-8	2020	In post-NAC metastatic lesions, the frequency of immunoexpression of PD-L1 and IDO1 was increased compared with that in pre-NAC specimens.	nac	8-11	indoleamine 2,3-dioxygenase 1	Homo sapiens	79-83
32388585-8	2020	In post-NAC metastatic lesions, the frequency of immunoexpression of PD-L1 and IDO1 was increased compared with that in pre-NAC specimens.	nac	124-127	CD274 molecule	Homo sapiens	69-74
32388585-8	2020	In post-NAC metastatic lesions, the frequency of immunoexpression of PD-L1 and IDO1 was increased compared with that in pre-NAC specimens.	nac	124-127	indoleamine 2,3-dioxygenase 1	Homo sapiens	79-83
32613608-2	2020	The aim of this study was to assess the impact of progesterone receptor (PgR) status on response to neoadjuvant chemotherapy (NAC) in estrogen receptor (ER)+, human epidermal growth factor receptor (HER)- breast cancer patients.	nac	126-129	progesterone receptor	Homo sapiens	50-71
32613608-2	2020	The aim of this study was to assess the impact of progesterone receptor (PgR) status on response to neoadjuvant chemotherapy (NAC) in estrogen receptor (ER)+, human epidermal growth factor receptor (HER)- breast cancer patients.	nac	126-129	progesterone receptor	Homo sapiens	73-76
32613608-2	2020	The aim of this study was to assess the impact of progesterone receptor (PgR) status on response to neoadjuvant chemotherapy (NAC) in estrogen receptor (ER)+, human epidermal growth factor receptor (HER)- breast cancer patients.	nac	126-129	estrogen receptor 1	Homo sapiens	134-151
32613608-2	2020	The aim of this study was to assess the impact of progesterone receptor (PgR) status on response to neoadjuvant chemotherapy (NAC) in estrogen receptor (ER)+, human epidermal growth factor receptor (HER)- breast cancer patients.	nac	126-129	estrogen receptor 1	Homo sapiens	153-155
32613608-2	2020	The aim of this study was to assess the impact of progesterone receptor (PgR) status on response to neoadjuvant chemotherapy (NAC) in estrogen receptor (ER)+, human epidermal growth factor receptor (HER)- breast cancer patients.	nac	126-129	epidermal growth factor receptor	Homo sapiens	165-197
32613608-11	2020	CONCLUSION: Over 30% of ER+, PgR-, and HER- patients will have a breast pCR after NAC.	nac	82-85	estrogen receptor 1	Homo sapiens	24-26
32613608-11	2020	CONCLUSION: Over 30% of ER+, PgR-, and HER- patients will have a breast pCR after NAC.	nac	82-85	progesterone receptor	Homo sapiens	29-32
32613608-13	2020	ER+, PgR-, and HER- patients should be considered for NAC.	nac	54-57	estrogen receptor 1	Homo sapiens	0-2
32607760-9	2020	Decreasing ROS level by NAC can inhibit the NLRP3 inflammasome activation, secretion of IL-1beta and apoptosis in Dox-treating H9c2 cells and primary cardiomyocytes.	nac	24-27	NLR family, pyrin domain containing 3	Rattus norvegicus	44-49
32607760-9	2020	Decreasing ROS level by NAC can inhibit the NLRP3 inflammasome activation, secretion of IL-1beta and apoptosis in Dox-treating H9c2 cells and primary cardiomyocytes.	nac	24-27	interleukin 1 alpha	Rattus norvegicus	88-96
32891517-8	2020	The findings suggest that alterations in MAGL activity and BDNF expression in the hippocampal-NAc network contribute to the depressive-like behavioral phenotype in ELS males and females.	nac	94-97	monoglyceride lipase	Rattus norvegicus	41-45
32891517-8	2020	The findings suggest that alterations in MAGL activity and BDNF expression in the hippocampal-NAc network contribute to the depressive-like behavioral phenotype in ELS males and females.	nac	94-97	brain-derived neurotrophic factor	Rattus norvegicus	59-63
32898010-8	2020	Gene expression analysis showed that the functions of regulatory T cells, B cells, and natural killer CD56 dim cells were significantly decreased in the NAC group.	nac	153-156	neural cell adhesion molecule 1	Homo sapiens	102-106
33102228-13	2020	Conclusions: Our study demonstrated rs6484711 polymorphism regulating ABTB2 expression might predict efficacy to epirubicin based NAC in luminal A breast cancer patients.	nac	130-133	ankyrin repeat and BTB domain containing 2	Homo sapiens	70-75
32694134-4	2020	NAC (NAM, ATAF and CUC) proteins MaNAC1 and MaNAC2 repress the expression of MaERF11, a protein previously known to negatively regulate ethylene biosynthesis genes MaACS1 and MaACO1.	nac	0-3	1-aminocyclopropane-1-carboxylate synthase	Musa acuminata	164-170
33209672-8	2020	pCR rate and pPR rate of NAC are 0.10 (0.07-0.13) and 0.40 (95% CI: 0.32-0.49, P <0.001) respectively.	nac	25-28	PPR1	Homo sapiens	13-16
32992708-4	2020	Given the role of tumor infiltrating lymphocytes in NAC and since TNBC has the most abundant immune cell infiltration in breast cancer, we hypothesized that the ITPKC expression level is associated with NAC response and prognosis in TNBC.	nac	52-55	inositol-trisphosphate 3-kinase C	Homo sapiens	161-166
32992708-4	2020	Given the role of tumor infiltrating lymphocytes in NAC and since TNBC has the most abundant immune cell infiltration in breast cancer, we hypothesized that the ITPKC expression level is associated with NAC response and prognosis in TNBC.	nac	203-206	inositol-trisphosphate 3-kinase C	Homo sapiens	161-166
32992708-8	2020	TNBC with low ITPKC achieved a significantly higher pCR rate after NAC.	nac	67-70	inositol-trisphosphate 3-kinase C	Homo sapiens	14-19
32982426-1	2020	Purpose: Pathological complete response (pCR) is the goal of neoadjuvant chemotherapy (NAC) for the HER2-positive and triple-negative subtypes of breast cancer and is related to survival benefit; however, luminal breast cancer is not sensitive to NAC, and the size of tumor shrinkage is a more meaningful clinical indicator for the luminal breast cancer subtype.	nac	87-90	erb-b2 receptor tyrosine kinase 2	Homo sapiens	100-104
32957507-9	2020	MTVcsc successfully predicted pathologic tumor response to NAC in HER2-positive/triple-negative subtypes (accuracy, 74%) but not in the luminal subtype (accuracy, 29%).	nac	59-62	erb-b2 receptor tyrosine kinase 2	Homo sapiens	66-70
32957507-11	2020	A novel data-driven PET parameter for CSC metabolism provides early prediction of pCR after NAC and DFS in HER2-positive and triple-negative subtypes.	nac	92-95	erb-b2 receptor tyrosine kinase 2	Homo sapiens	107-111
32924285-3	2020	We sought to examine how NAC ATTR stage changes during follow-up and whether it maintains its prognostic value throughout the disease course.	nac	25-28	transthyretin	Homo sapiens	29-33
32924285-7	2020	Cox regression analyses were performed to assess the prognostic significance during follow-up of an increase in NAC ATTR stage from Stage I at diagnosis.	nac	112-115	transthyretin	Homo sapiens	116-120
32924285-10	2020	An increase from NAC ATTR Stage I, which occurred in 21%, 32%, and 44% of evaluable patients at 6, 12, and 24 months of follow-up respectively, was highly predictive of ongoing mortality at each time point (HRs 2.58-3.22; P < 0.001) and in each genotypic subgroup (HRs 1.86-4.38; P < 0.05).	nac	17-20	transthyretin	Homo sapiens	21-25
32924285-11	2020	Increase in NAC ATTR stage occurred earlier in V122I-hATTR-CM than in wtATTR-CM (43% vs. 27% at 12 months of follow-up; P = 0.003).	nac	12-15	transthyretin	Homo sapiens	16-20
32924285-13	2020	Serial calculation of NAC ATTR stage suggests a more aggressive phenotype in V122I-hATTR-CM than in wtATTR-CM.	nac	22-25	transthyretin	Homo sapiens	26-30
32602000-17	2020	The combination of CEUS and BD is more effective than BD alone for SLNB in patients converting from cN1 to cN0 following NAC.	nac	121-124	5'-nucleotidase, cytosolic IA	Homo sapiens	100-103
32165095-3	2020	Using a cohort of 58 patients from two phase 2 trials, our group previously reported that mutations in the ATM, RB1, and FANCC genes correlate with complete response to cisplatin-based NAC, and consequently improve OS and disease-specific survival (DSS).	nac	185-188	ATM serine/threonine kinase	Homo sapiens	107-110
32905537-6	2020	In mRNA-hub gene analysis, HSP90AA1, EEF1A1, APP, and HSPA4 were related to recurrence in BC patients with pCR due to NAC.	nac	118-121	heat shock protein 90 alpha family class A member 1	Homo sapiens	27-35
32905537-6	2020	In mRNA-hub gene analysis, HSP90AA1, EEF1A1, APP, and HSPA4 were related to recurrence in BC patients with pCR due to NAC.	nac	118-121	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	37-43
32905537-6	2020	In mRNA-hub gene analysis, HSP90AA1, EEF1A1, APP, and HSPA4 were related to recurrence in BC patients with pCR due to NAC.	nac	118-121	heat shock protein family A (Hsp70) member 4	Homo sapiens	54-59
32430911-5	2020	Here, we identified a NAC TF, ZmNAC126 that is responsive to leaf senescence in maize.	nac	22-25	NAC domain-containing protein 45	Zea mays	30-38
33110814-3	2020	Aims: To find out the difference in the expression of PD-L1 by tumor cells after the administration of NAC.	nac	103-106	CD274 molecule	Homo sapiens	54-59
33110814-15	2020	Conclusion: PD-L1 expression in a same person changes upon administration of NAC which may indirectly be used as a predictor of response to NAC.	nac	77-80	CD274 molecule	Homo sapiens	12-17
33110814-15	2020	Conclusion: PD-L1 expression in a same person changes upon administration of NAC which may indirectly be used as a predictor of response to NAC.	nac	140-143	CD274 molecule	Homo sapiens	12-17
32953748-11	2020	Univariate analysis revealed that patients with carcinoembryonic antigen (CEA) <5.0 ng/ml after NAC (77.7% vs. 20.1%, P<0.001), distal gastrectomy (91.7% vs. 67.5%, P=0.046) had higher 5-year RFS.	nac	96-99	CEA cell adhesion molecule 3	Homo sapiens	74-77
32953748-13	2020	The multivariate analysis showed that CEA level after NAC (HR =2.876, 95% CI: 1.051-7.872, P=0.040), major complications (HR =2.432, 95% CI: 1.062-5.567, P=0.035), and lymph node metastasis (ypN+) (HR =3.183, 95% CI: 1.242-8.161, P=0.016) were independent prognostic factors.	nac	54-57	CEA cell adhesion molecule 3	Homo sapiens	38-41
32953748-14	2020	Conclusions: TRG 0 and 1 patients with local GC after R0 resection following NAC had a good prognosis, especially patients with CEA <5.0 ng/mL after NAC, and those without major complications or lymph node metastasis.	nac	77-80	tRNA-Gly (anticodon CCC) 1-1	Homo sapiens	13-24
32953748-14	2020	Conclusions: TRG 0 and 1 patients with local GC after R0 resection following NAC had a good prognosis, especially patients with CEA <5.0 ng/mL after NAC, and those without major complications or lymph node metastasis.	nac	149-152	tRNA-Gly (anticodon CCC) 1-1	Homo sapiens	13-24
32165095-3	2020	Using a cohort of 58 patients from two phase 2 trials, our group previously reported that mutations in the ATM, RB1, and FANCC genes correlate with complete response to cisplatin-based NAC, and consequently improve OS and disease-specific survival (DSS).	nac	185-188	FA complementation group C	Homo sapiens	121-126
32165095-3	2020	Using a cohort of 58 patients from two phase 2 trials, our group previously reported that mutations in the ATM, RB1, and FANCC genes correlate with complete response to cisplatin-based NAC, and consequently improve OS and disease-specific survival (DSS).	nac	185-188	RB transcriptional corepressor 1	Homo sapiens	112-115
32422166-3	2020	The NAc shell has a high density of synaptically co-localized cannabinoid receptor type-1 (CB1R) and TRPV1, suggesting a potential involvement in the modulation of anxiety.	nac	4-7	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	101-106
32724406-7	2020	Univariate and multivariate logistic regressions were used to analyze whether PCDH17 methylation status predicted a curative effect of NAC.	nac	135-138	protocadherin 17	Homo sapiens	78-84
32724406-13	2020	The present results demonstrate that PCDH17 methylation status may predict the response to NAC in patients with TNBC.	nac	91-94	protocadherin 17	Homo sapiens	37-43
32774771-6	2020	Furthermore, TIMP1 and DSG2 were identified as predictive biomarkers of the pathological response to each NAC regimen.	nac	106-109	TIMP metallopeptidase inhibitor 1	Homo sapiens	13-18
32774771-6	2020	Furthermore, TIMP1 and DSG2 were identified as predictive biomarkers of the pathological response to each NAC regimen.	nac	106-109	desmoglein 2	Homo sapiens	23-27
32422166-4	2020	OBJECTIVES: The present study aims to establish the role of ECS-TRPV1 interactions within the NAc shell and its effects on anxiety.	nac	94-97	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	64-69
32422166-12	2020	CONCLUSIONS: The present findings suggest that the ECS within the NAc shell modulates anxiety-like behaviors via FAAH and CB1R activity.	nac	66-69	fatty-acid amide hydrolase-like	Rattus norvegicus	113-117
32656523-11	2020	Conclusion: The pCR rate after NAC in ER+/HER2- subtypes of breast cancer is low.	nac	31-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-46
32708049-4	2020	Major evolution events during BC NAC that feature the Residual Disease (RD) are the loss of HR and HER2, which are prognostic of bad outcome, and stemness and immune depletion-related gene expression aberrations.	nac	33-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	99-103
32733470-12	2020	We found a positive correlation between plasma Interleukin 10 (IL-10) and classical monocytes in HER2+ BC patients under NAC.	nac	121-124	interleukin 10	Homo sapiens	47-61
32733470-12	2020	We found a positive correlation between plasma Interleukin 10 (IL-10) and classical monocytes in HER2+ BC patients under NAC.	nac	121-124	interleukin 10	Homo sapiens	63-68
32733470-12	2020	We found a positive correlation between plasma Interleukin 10 (IL-10) and classical monocytes in HER2+ BC patients under NAC.	nac	121-124	erb-b2 receptor tyrosine kinase 2	Homo sapiens	97-101
32733470-13	2020	We also observed a trend between increased IL-10 and classical monocytes levels and lower rates of pathologic complete response at the end of NAC.	nac	142-145	interleukin 10	Homo sapiens	43-48
32733470-14	2020	These data support the notion that monocyte subsets and IL-10 could be applied as a novel indicator of NAC efficacy in HER2+ BC patients.	nac	103-106	interleukin 10	Homo sapiens	56-61
32733470-14	2020	These data support the notion that monocyte subsets and IL-10 could be applied as a novel indicator of NAC efficacy in HER2+ BC patients.	nac	103-106	erb-b2 receptor tyrosine kinase 2	Homo sapiens	119-123
32428531-10	2020	These findings revealed that BDNF and p-CREB/CREB ratio in the NAc are essential factors for effort-based but not delay-based decision making.	nac	63-66	brain-derived neurotrophic factor	Rattus norvegicus	29-33
31325134-3	2020	The purpose of this study was to clarify the impact of NAC on surgical outcomes and prognosis in DP-CAR patients.	nac	55-58	CXADR pseudogene 1	Homo sapiens	100-103
31325134-11	2020	CONCLUSION: DP-CAR following NAC was associated with a preferable prognosis and had no negative effect on surgical outcomes.	nac	29-32	CXADR pseudogene 1	Homo sapiens	15-18
31325134-12	2020	Therefore, NAC in DP-CAR patients might be a beneficial and safe therapeutic strategy.	nac	11-14	CXADR pseudogene 1	Homo sapiens	21-24
32335205-7	2020	When rats were conditioned with intra-NAc shell infusions of CART, CPP and CPA induced with 2.5 and 5 mug/side respectively and IHC showed NR1elevation with 2.5 and reduction with 5 mug/side in all areas.	nac	38-41	CART prepropeptide	Rattus norvegicus	61-65
32428531-10	2020	These findings revealed that BDNF and p-CREB/CREB ratio in the NAc are essential factors for effort-based but not delay-based decision making.	nac	63-66	cAMP responsive element binding protein 1	Rattus norvegicus	40-44
32428531-10	2020	These findings revealed that BDNF and p-CREB/CREB ratio in the NAc are essential factors for effort-based but not delay-based decision making.	nac	63-66	cAMP responsive element binding protein 1	Rattus norvegicus	45-49
32361849-5	2020	Immunohistochemistry was used to detect CXCR1 and CXCR2 expression in patients with residual tumors after NAC.	nac	106-109	C-X-C motif chemokine receptor 1	Homo sapiens	40-45
32493336-5	2020	RESULTS: The fraction of patients with high PD-L1 expression was significantly increased from 32.4 to 46.5% after NAC (chi2 = 5.897, p = 0.015), while the increase of CD3+, CD4+, CD8+ TILs was not significant.	nac	114-117	CD274 molecule	Homo sapiens	44-49
32493336-6	2020	High PD-L1 expression was not associated with CD3+, CD4+, CD8+ TILs before NAC, however CD8+ TILs infiltration was positively associated with high PD-L1 expression after NAC (r = 0.205, p = 0.014).	nac	170-173	CD8a molecule	Homo sapiens	88-91
32493336-6	2020	High PD-L1 expression was not associated with CD3+, CD4+, CD8+ TILs before NAC, however CD8+ TILs infiltration was positively associated with high PD-L1 expression after NAC (r = 0.205, p = 0.014).	nac	170-173	CD274 molecule	Homo sapiens	147-152
32493336-7	2020	The decreased PD-L1 expression was more observed in patients with clinical response to NAC (chi2 = 6.890, p = 0.009).	nac	87-90	CD274 molecule	Homo sapiens	14-19
32277375-4	2020	We evaluated the correlation between HER2/CEP17 ratio and partial versus complete response following NAC.	nac	101-104	erb-b2 receptor tyrosine kinase 2	Homo sapiens	37-41
32277375-5	2020	We evaluated whether patients with higher HER2/CEP17 ratios would have higher rates of pCR after NAC.	nac	97-100	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-46
32277375-10	2020	29,291 of these patients underwent NAC, and HER2/CEP17 ratios were recorded in 14,597 of the NAC cases.	nac	93-96	erb-b2 receptor tyrosine kinase 2	Homo sapiens	44-48
32544191-6	2020	In contrast, the antioxidant NAC and loss of sod-1, both of which decrease cytoplasmic H202, enhance the activity of LET-60rasgf.	nac	29-32	Ras protein let-60	Caenorhabditis elegans	117-123
32361849-5	2020	Immunohistochemistry was used to detect CXCR1 and CXCR2 expression in patients with residual tumors after NAC.	nac	106-109	C-X-C motif chemokine receptor 2	Homo sapiens	50-55
32277375-14	2020	CONCLUSION: Our study demonstrates a linear relationship between HER2/CEP17 ratio and pCR to NAC in patients included in the NCDB.	nac	93-96	erb-b2 receptor tyrosine kinase 2	Homo sapiens	65-69
32277375-15	2020	The NCDB reflects current clinical practices across the country, and in this patient population, higher HER2 ratio is predictive of pCR to NAC and thus may be used in guiding decisions regarding the therapies that a patient receives in order to enhance pCR.	nac	139-142	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-108
32361849-8	2020	CXCL8 level was significantly upgraded after NAC in CXCR1/2+ patients and downgraded after NAC in CXCR1/2- patients.	nac	45-48	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
32361849-8	2020	CXCL8 level was significantly upgraded after NAC in CXCR1/2+ patients and downgraded after NAC in CXCR1/2- patients.	nac	45-48	C-X-C motif chemokine receptor 1	Homo sapiens	52-59
32361849-8	2020	CXCL8 level was significantly upgraded after NAC in CXCR1/2+ patients and downgraded after NAC in CXCR1/2- patients.	nac	91-94	C-X-C motif chemokine ligand 8	Homo sapiens	0-5
32361849-13	2020	The CXCL8-CXCR1/2 might play an important role in tailoring and modifying the NAC strategy for advanced TNBCs; however, further confirmatory studies are needed.	nac	78-81	C-X-C motif chemokine ligand 8	Homo sapiens	4-9
32361849-13	2020	The CXCL8-CXCR1/2 might play an important role in tailoring and modifying the NAC strategy for advanced TNBCs; however, further confirmatory studies are needed.	nac	78-81	C-X-C motif chemokine receptor 1	Homo sapiens	10-17
32576021-11	2020	The author describes the history, current situation, and future direction of NAC for HER2-negative breast cancer in the review article.	nac	77-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	85-89
31140064-13	2020	The Cox regression model demonstrated that POCs were independently associated with worse DFS (HR [hazard ratio] 2.128, 95% CI 1.240-3.653, p = 0.006) but not OS for patients treated with NAC.	nac	187-190	cytochrome c oxidase subunit 8A	Homo sapiens	4-7
32595988-9	2020	Conclusion: We found that the addition of trastuzumab to NAC improved relative survival benefit in HER2+/HR+ patients than in HER2+/HR- patients, even though the pCR rate increases were lower.	nac	57-60	erb-b2 receptor tyrosine kinase 2	Homo sapiens	99-103
32486150-6	2020	Also, the prepared NAC was characterized by SEM, EDX, TEM, Raman Spectroscopy, and BET analyses.	nac	19-22	delta/notch like EGF repeat containing	Homo sapiens	83-86
32429929-7	2020	RESULTS: This analysis showed decreased ICP expression by circulating CD4+ T cells after NAC, including significant decreases in CTLA4, Lag3, OX40, and PD-1 (all p values < 0.01).	nac	89-92	CD4 molecule	Homo sapiens	70-73
32429929-9	2020	Within tumor samples, TILs, CD8+ T cells, and PD-L1/PD-1 expression decreased after NAC.	nac	84-87	CD274 molecule	Homo sapiens	46-51
32429929-9	2020	Within tumor samples, TILs, CD8+ T cells, and PD-L1/PD-1 expression decreased after NAC.	nac	84-87	programmed cell death 1	Homo sapiens	52-56
32429929-10	2020	Additionally, fewer tumor specimens were considered to be PD-L1/PD-1 positive post-NAC as compared to pre-NAC biopsy samples using a cutoff of 1% expression.	nac	83-86	CD274 molecule	Homo sapiens	58-63
32429929-10	2020	Additionally, fewer tumor specimens were considered to be PD-L1/PD-1 positive post-NAC as compared to pre-NAC biopsy samples using a cutoff of 1% expression.	nac	83-86	programmed cell death 1	Homo sapiens	64-68
32429929-11	2020	CONCLUSIONS: This work revealed that NAC treatment can substantially downregulate CD4+ and upregulate CD8+ T cell ICP expression as well as deplete the amount of TILs and CD8+ T cells found in breast tumor samples.	nac	37-40	CD4 molecule	Homo sapiens	82-85
32429929-11	2020	CONCLUSIONS: This work revealed that NAC treatment can substantially downregulate CD4+ and upregulate CD8+ T cell ICP expression as well as deplete the amount of TILs and CD8+ T cells found in breast tumor samples.	nac	37-40	CD8a molecule	Homo sapiens	102-105
32429929-11	2020	CONCLUSIONS: This work revealed that NAC treatment can substantially downregulate CD4+ and upregulate CD8+ T cell ICP expression as well as deplete the amount of TILs and CD8+ T cells found in breast tumor samples.	nac	37-40	CD8a molecule	Homo sapiens	171-174
32595988-11	2020	Further longer-term evaluation of the objective survival benefit after NAC driven by a dual HER2 block according to HR status is warranted.	nac	71-74	erb-b2 receptor tyrosine kinase 2	Homo sapiens	92-96
31463561-11	2020	Our results indicate that patients with a cT3-T4 disease are those who might benefit more from NAC whereas those with T2 single disease should be those to whom NAC probably shouldn"t be proposed.	nac	95-98	cancer antigen 1	Homo sapiens	42-45
32107612-3	2020	Members of the NAC (NAM, ATAF1/2, and CUC2) transcription factor (TF) family participate in drought-stress-induced signal transduction in plants, but little is known about the roles of NAC genes in drought tolerance in grapevine.	nac	15-18	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	20-23
32107612-3	2020	Members of the NAC (NAM, ATAF1/2, and CUC2) transcription factor (TF) family participate in drought-stress-induced signal transduction in plants, but little is known about the roles of NAC genes in drought tolerance in grapevine.	nac	15-18	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	38-42
32107612-3	2020	Members of the NAC (NAM, ATAF1/2, and CUC2) transcription factor (TF) family participate in drought-stress-induced signal transduction in plants, but little is known about the roles of NAC genes in drought tolerance in grapevine.	nac	185-188	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	20-23
31463561-12	2020	Given the high rate of understaging in BCa patients, NAC can be proposed in selected cases of cT2/multifocal disease.	nac	53-56	solute carrier family 6 member 10, pseudogene	Homo sapiens	94-97
32234876-3	2020	MATERIALS AND METHODS: TIL level was histologically analyzed in pre-NAC biopsy and post-NAC operation specimens from 104 TNBC cases with residual invasive carcinoma after NAC.	nac	88-91	toll like receptor 1	Homo sapiens	23-26
32332867-12	2020	These effects were prevented by the inhibition of NLRP3 inflammasome by CASP1 or oxidative stress by NAC.	nac	101-104	NLR family, pyrin domain containing 3	Rattus norvegicus	50-55
32308485-2	2020	This study aims to evaluate the alternative application of Magee Equation 2 score in predicting pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in hormone receptor (HR)-positive, HER2-negative breast cancer.	nac	165-168	nuclear receptor subfamily 4 group A member 1	Homo sapiens	173-189
32308485-2	2020	This study aims to evaluate the alternative application of Magee Equation 2 score in predicting pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in hormone receptor (HR)-positive, HER2-negative breast cancer.	nac	165-168	nuclear receptor subfamily 4 group A member 1	Homo sapiens	191-193
32308485-2	2020	This study aims to evaluate the alternative application of Magee Equation 2 score in predicting pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in hormone receptor (HR)-positive, HER2-negative breast cancer.	nac	165-168	erb-b2 receptor tyrosine kinase 2	Homo sapiens	205-209
32308485-13	2020	Conclusion: Among patients with HR-positive and HER2-negative breast cancer treated with NAC, Magee Equation 2 might be used as a tool for predicting the pCR and clinical outcome.	nac	89-92	nuclear receptor subfamily 4 group A member 1	Homo sapiens	32-34
32308485-13	2020	Conclusion: Among patients with HR-positive and HER2-negative breast cancer treated with NAC, Magee Equation 2 might be used as a tool for predicting the pCR and clinical outcome.	nac	89-92	erb-b2 receptor tyrosine kinase 2	Homo sapiens	48-52
32234876-3	2020	MATERIALS AND METHODS: TIL level was histologically analyzed in pre-NAC biopsy and post-NAC operation specimens from 104 TNBC cases with residual invasive carcinoma after NAC.	nac	68-71	toll like receptor 1	Homo sapiens	23-26
32234876-3	2020	MATERIALS AND METHODS: TIL level was histologically analyzed in pre-NAC biopsy and post-NAC operation specimens from 104 TNBC cases with residual invasive carcinoma after NAC.	nac	88-91	toll like receptor 1	Homo sapiens	23-26
32234876-7	2020	CONCLUSION: We identified a prognostic significance of TIL changes after NAC.	nac	73-76	toll like receptor 1	Homo sapiens	55-58
32140811-2	2020	We present long-term survival outcomes (disease-free survival [DFS], pre-planned secondary endpoint; overall survival [OS], post hoc exploratory endpoint) of our randomized study of the addition of CBDCA to NAC for HER2-negative breast cancer.	nac	207-210	erb-b2 receptor tyrosine kinase 2	Homo sapiens	215-219
32002765-5	2020	HER2 connectivity and other factors including age, histologic grade, ER, PR, and HER2 fluorescence in situ hybridization (FISH) were analyzed for association with the response to anti-HER2 NAC.	nac	189-192	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
32218822-7	2020	In regard to TP53 mutation, the rate of TP53 mutation in the NAC-resistant cases was significantly higher compared with NAC-sensitive cases.	nac	61-64	tumor protein p53	Homo sapiens	13-17
32513358-11	2020	Patients with HER2-positive tumors were more sensitive to NAC regimen including trastuzumab.	nac	58-61	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-18
32513358-12	2020	CONCLUSION: In this study, breast cancer patients with high histological grade, negative HR status and lymph nodes, positive HER2 status, as well as taxane-based regimens were significantly associated with achieving pCR with NAC.	nac	225-228	erb-b2 receptor tyrosine kinase 2	Homo sapiens	125-129
31256745-1	2020	BACKGROUND: Pertuzumab-based neoadjuvant chemotherapy (NAC) has demonstrated successful pathologic complete response (pCR) rates when administered to patients with human epidermal growth factor receptor 2 (HER2)-positive, locally advanced breast cancer and has become standard of care.	nac	55-58	erb-b2 receptor tyrosine kinase 2	Homo sapiens	170-204
31256745-1	2020	BACKGROUND: Pertuzumab-based neoadjuvant chemotherapy (NAC) has demonstrated successful pathologic complete response (pCR) rates when administered to patients with human epidermal growth factor receptor 2 (HER2)-positive, locally advanced breast cancer and has become standard of care.	nac	55-58	erb-b2 receptor tyrosine kinase 2	Homo sapiens	206-210
30767115-9	2020	In the subgroup analysis of local recurrence between the NAC treated group and those who received surgery alone, high levels of PD-1 and PD-L1 expressions were significantly found in the former, but not in the latter group.	nac	57-60	programmed cell death 1	Homo sapiens	128-132
30767115-9	2020	In the subgroup analysis of local recurrence between the NAC treated group and those who received surgery alone, high levels of PD-1 and PD-L1 expressions were significantly found in the former, but not in the latter group.	nac	57-60	CD274 molecule	Homo sapiens	137-142
32218822-7	2020	In regard to TP53 mutation, the rate of TP53 mutation in the NAC-resistant cases was significantly higher compared with NAC-sensitive cases.	nac	61-64	tumor protein p53	Homo sapiens	40-44
32218822-7	2020	In regard to TP53 mutation, the rate of TP53 mutation in the NAC-resistant cases was significantly higher compared with NAC-sensitive cases.	nac	120-123	tumor protein p53	Homo sapiens	13-17
32218822-7	2020	In regard to TP53 mutation, the rate of TP53 mutation in the NAC-resistant cases was significantly higher compared with NAC-sensitive cases.	nac	120-123	tumor protein p53	Homo sapiens	40-44
32218822-9	2020	These results indicated that gene mutation can be profiled and monitored using liquid biopsy-based CAPP-Seq in patients with advanced ovarian cancer with NAC treatment, and TP53 mutation in the ctDNA and bTMB may be novel biomarkers that can be used for patient monitoring during NAC treatment.	nac	280-283	tumor protein p53	Homo sapiens	173-177
32193458-2	2020	Herein, we find that overexpression of Rac1 is associated with multi-drug resistance to the neoadjuvant chemotherapy (NAC).	nac	118-121	Rac family small GTPase 1	Homo sapiens	39-43
32197645-14	2020	Moreover, cholesterol triggered reactive oxygen species (ROS) generation and activated the AKT/FOXO1 pathway, while the ROS scavenger NAC blocked cholesterol-induced activation of the AKT/FOXO1 pathway.	nac	134-137	AKT serine/threonine kinase 1	Rattus norvegicus	184-187
32197645-14	2020	Moreover, cholesterol triggered reactive oxygen species (ROS) generation and activated the AKT/FOXO1 pathway, while the ROS scavenger NAC blocked cholesterol-induced activation of the AKT/FOXO1 pathway.	nac	134-137	forkhead box O1	Rattus norvegicus	188-193
32193458-5	2020	To translate this finding, we develop endosomal pH-responsive nanoparticles (NPs) which deliver Rac1-targeting siRNA together with cisplatin and effectively reverses NAC-chemoresistance in PDXs from NAC-resistant breast cancer patients.	nac	166-169	Rac family small GTPase 1	Homo sapiens	96-100
32193458-5	2020	To translate this finding, we develop endosomal pH-responsive nanoparticles (NPs) which deliver Rac1-targeting siRNA together with cisplatin and effectively reverses NAC-chemoresistance in PDXs from NAC-resistant breast cancer patients.	nac	199-202	Rac family small GTPase 1	Homo sapiens	96-100
31204155-6	2020	RESULTS: Negative status of estrogen receptor (ER) was associated with locoregional recurrence and distant metastasis both before and after NAC (p = 0.021, 0.019; p = 0.018, 0.036).	nac	140-143	estrogen receptor 1	Homo sapiens	28-45
32309426-10	2020	The changes in NK, CD3+, CD4+, and CD8+ cell percentages were attenuated in the NAC-CHO group (P < 0.05 vs. both other groups).	nac	80-83	CD4 molecule	Homo sapiens	25-28
32309426-10	2020	The changes in NK, CD3+, CD4+, and CD8+ cell percentages were attenuated in the NAC-CHO group (P < 0.05 vs. both other groups).	nac	80-83	CD8a molecule	Homo sapiens	35-38
32195182-10	2020	Those with the greatest ability to predict poor-NAC response were GRP78, CADM1, PGES2, and RUXF.	nac	48-51	heat shock protein family A (Hsp70) member 5	Homo sapiens	66-71
32195182-10	2020	Those with the greatest ability to predict poor-NAC response were GRP78, CADM1, PGES2, and RUXF.	nac	48-51	cell adhesion molecule 1	Homo sapiens	73-78
31204155-6	2020	RESULTS: Negative status of estrogen receptor (ER) was associated with locoregional recurrence and distant metastasis both before and after NAC (p = 0.021, 0.019; p = 0.018, 0.036).	nac	140-143	estrogen receptor 1	Homo sapiens	47-49
31919848-9	2020	CONCLUSIONS: After adjusting for imbalances in our subgroups, we found that, regardless of the sequence of chemotherapy (AC vs. NAC), patients with early-stage HER2+ breast cancer had excellent outcomes.	nac	128-131	erb-b2 receptor tyrosine kinase 2	Homo sapiens	160-164
32521866-10	2020	After treatment, the levels of serum human epididymis protein 4 (HE4) and carbohydrate antigen 125 (CA125) were evidently higher in NAC + IPHC group than in IPHC group, while they were also evidently higher in IPHC group than in control group.	nac	132-135	WAP four-disulfide core domain 2	Homo sapiens	65-68
31879365-7	2020	MUC17 variants were identified in 3 tumors and were selected against by NAC in each case, while PCNX1 variants were identified in 2 tumors and were selected for in both cases, implicating the function of these genes in defining chemoresponse.	nac	72-75	mucin 17, cell surface associated	Homo sapiens	0-5
31519449-1	2020	BACKGROUND: In human epidermal growth factor receptor 2-positive (HER2+) breast cancer, the incorporation of a dual HER2 blockade into neoadjuvant chemotherapy (NAC) has been shown to induce a higher rate of pathologic complete response (pCR).	nac	161-164	erb-b2 receptor tyrosine kinase 2	Homo sapiens	21-55
32106831-9	2020	In the high NDRG1 group of biopsy specimens before NAC, the tumor reduction rate by NAC was significantly attenuated (P = 0.021).	nac	51-54	N-myc downstream regulated 1	Homo sapiens	12-17
32106831-9	2020	In the high NDRG1 group of biopsy specimens before NAC, the tumor reduction rate by NAC was significantly attenuated (P = 0.021).	nac	84-87	N-myc downstream regulated 1	Homo sapiens	12-17
32106831-10	2020	CONCLUSIONS: High GR, Sgk1, and NDRG1 statuses in ESCC after NAC was significantly associated with an overall worse prognosis, with no significant changes in their expression levels before and after NAC.	nac	61-64	N-myc downstream regulated 1	Homo sapiens	32-37
32106831-11	2020	Therefore, increased activity of the GC-GR pathway with enhanced induction of Sgk1 and NDRG1 in carcinoma cells play pivotal roles in tumor progression and development of chemo-resistance in patients with ESCC undergoing NAC.	nac	221-224	serum/glucocorticoid regulated kinase 1	Homo sapiens	78-82
32106831-11	2020	Therefore, increased activity of the GC-GR pathway with enhanced induction of Sgk1 and NDRG1 in carcinoma cells play pivotal roles in tumor progression and development of chemo-resistance in patients with ESCC undergoing NAC.	nac	221-224	N-myc downstream regulated 1	Homo sapiens	87-92
32104078-1	2020	Purpose: Few models with good discriminative power have been introduced to predict the risk of non-sentinel lymph node (non-SLN) metastasis in breast cancer after neoadjuvant chemotherapy (NAC).	nac	189-192	sarcolipin	Homo sapiens	124-127
32104078-9	2020	Conclusion: A new and simple model, which incorporated factors that could be determined prior to breast surgery, was developed to predict non-SLN metastasis in invasive breast cancer following NAC.	nac	193-196	sarcolipin	Homo sapiens	142-145
32102539-2	2020	METHODOLOGY: We retrospectively estimated the predictive value of the AR expression in stage II and stage III TNBC patients treated with neoadjuvant chemotherapy (NAC) and correlated with the rate of pathological response (pCR).	nac	163-166	androgen receptor	Homo sapiens	70-72
32102539-10	2020	CONCLUSION: Our results suggested that the AR expression in TNBC may be applied as a predictive marker for NAC.	nac	107-110	androgen receptor	Homo sapiens	43-45
31519449-1	2020	BACKGROUND: In human epidermal growth factor receptor 2-positive (HER2+) breast cancer, the incorporation of a dual HER2 blockade into neoadjuvant chemotherapy (NAC) has been shown to induce a higher rate of pathologic complete response (pCR).	nac	161-164	erb-b2 receptor tyrosine kinase 2	Homo sapiens	66-70
31519449-1	2020	BACKGROUND: In human epidermal growth factor receptor 2-positive (HER2+) breast cancer, the incorporation of a dual HER2 blockade into neoadjuvant chemotherapy (NAC) has been shown to induce a higher rate of pathologic complete response (pCR).	nac	161-164	erb-b2 receptor tyrosine kinase 2	Homo sapiens	116-120
31519449-2	2020	The purpose of this study was to investigate whether pretreatment imaging and clinicopathologic features show any association with pCR in HER2+ breast cancer receiving NAC plus dual blockade.	nac	168-171	erb-b2 receptor tyrosine kinase 2	Homo sapiens	138-142
31519449-10	2020	CONCLUSION: Several pretreatment imaging and clinicopathologic features were shown to be independent variables predicting pCR in patients with HER2+ breast cancer receiving NAC with dual blockade.	nac	173-176	erb-b2 receptor tyrosine kinase 2	Homo sapiens	143-147
31464976-8	2020	Inhibition of ROS generation by NAC or p38 MAPK signaling by SB203580 attenuated the p53-mediated cell cycle arrest and apoptosis induced by LY.	nac	32-35	tumor protein p53	Homo sapiens	85-88
32329644-11	2020	It has also been elucidated that pre-treatment with NAC inhibited mitochondria-LC3B colocalization, where ROS acted as upstream of ERK1/2-p38 MAPKs activation.	nac	52-55	microtubule associated protein 1 light chain 3 beta	Homo sapiens	79-83
31367884-8	2020	Among these patients, those with initially cN1/N2 might be good candidates for a deescalated treatment strategy after NAC.	nac	118-121	5'-nucleotidase, cytosolic IA	Homo sapiens	43-46
32329644-11	2020	It has also been elucidated that pre-treatment with NAC inhibited mitochondria-LC3B colocalization, where ROS acted as upstream of ERK1/2-p38 MAPKs activation.	nac	52-55	mitogen-activated protein kinase 3	Homo sapiens	131-137
32473549-11	2020	This suggests that [68Ga]Ga-RM2 PET/CT merits further investigation for response assessment to NAC in patients with ER-positive BC.	nac	95-98	estrogen receptor 1	Homo sapiens	116-118
31529299-9	2020	CONCLUSIONS: These results suggest that the combination of pathological (RCB index) and tumor micro-environmental features (CD4 + TILs) help refining the prognosis of TNBC patients with RD following NAC.	nac	199-202	CD4 molecule	Homo sapiens	124-127
31526863-6	2019	We mapped key TF regulatory interactions and functionally validated the role of NAP, a NAC-domain containing TF, as a new regulatory factor in NO3- transport.	nac	87-90	NAC-like, activated by AP3/PI	Arabidopsis thaliana	80-83
31574500-3	2020	METHODS: HER2-positive primary breast cancer patients treated using NAC containing trastuzumab were enrolled between September 2006 and June 2017 at the Osaka Breast Clinic.	nac	68-71	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-13
31574500-13	2020	CONCLUSIONS: Positive clinical nodal status and young age were found to be prognostic factors before NAC in HER2-postive invasive breast cancer patients.	nac	101-104	erb-b2 receptor tyrosine kinase 2	Homo sapiens	108-112
31693870-9	2019	Also, the BDNF mRNA was down-regulated in the NAC.	nac	46-49	brain-derived neurotrophic factor	Rattus norvegicus	10-14
31795962-11	2019	CONCLUSIONS: CAIX expression was a predictor of pCR and was associated with higher DFS and DSS in locally advanced breast cancer patients subjected to NAC.	nac	151-154	carbonic anhydrase 9	Homo sapiens	13-17
31471838-1	2019	Biomarkers of breast cancer such as hormone receptors (HR) and human epidermal growth factor 2 (HER2) can be altered after neoadjuvant chemotherapy (NAC).	nac	149-152	erb-b2 receptor tyrosine kinase 2	Homo sapiens	96-100
31278574-1	2019	OBJECTIVES: We recently described metabolic nodal stage (mN) and response (mNR) of cancer of the esophagus and gastro-esophageal junction (GEJ) to neoadjuvant chemotherapy (NAC) using 18F-FDG PET-CT as new markers of disease progression, recurrence, and death.	nac	173-176	RIKEN cDNA 4933427D14 gene	Mus musculus	75-78
31278574-10	2019	CONCLUSIONS: This study provides temporal validation for mNR as a new and independent predictive and prognostic marker of esophageal and GEJ cancer treated with NAC and surgery, although external validation is required to assess generalizability.	nac	161-164	RIKEN cDNA 4933427D14 gene	Mus musculus	57-60
31897310-4	2019	However, the predictive and prognostic value for PD-L1 expression in cancer patients treated with neoadjuvant chemotherapy (NAC) is not yet established.	nac	124-127	CD274 molecule	Homo sapiens	49-54
31723167-12	2019	PD-L1 expression was associated with response to NAC with trastuzumab in patients with HER2-positive breast cancer.	nac	49-52	CD274 molecule	Homo sapiens	0-5
31723167-12	2019	PD-L1 expression was associated with response to NAC with trastuzumab in patients with HER2-positive breast cancer.	nac	49-52	erb-b2 receptor tyrosine kinase 2	Homo sapiens	87-91
31177629-9	2019	Endothelial-NOS mRNA levels were decreased in FGR adult compared with control and FGR-NAC (P &lt; .05), associated with increased DNA methylation levels (P &lt; .01).	nac	86-89	nitric oxide synthase, endothelial	Cavia porcellus	0-15
31222687-1	2019	BACKGROUND: Recent trials have demonstrated the feasibility of sentinel lymph node biopsy (SLNB) for cN1 breast cancer patients after neoadjuvant chemotherapy (NAC).	nac	160-163	5'-nucleotidase, cytosolic IA	Homo sapiens	101-104
31222687-3	2019	METHODS: From a prospective database, cT1-3 cN1 patients receiving NAC and surgery from 2016 to 2017 were identified.	nac	67-70	cardiotrophin 1	Homo sapiens	38-41
31222687-3	2019	METHODS: From a prospective database, cT1-3 cN1 patients receiving NAC and surgery from 2016 to 2017 were identified.	nac	67-70	5'-nucleotidase, cytosolic IA	Homo sapiens	44-47
31222687-11	2019	CONCLUSIONS: This study showed SLNB to be an effective tool for minimizing axillary surgery in cN1 patients treated with NAC.	nac	121-124	5'-nucleotidase, cytosolic IA	Homo sapiens	95-98
31328592-8	2019	Furthermore, application of the antioxidant NAC alleviates inhibition of gene expression levels by SWCNTs, as well as MAVS signalosome formation, and increased viral titers.	nac	44-47	mitochondrial antiviral signaling protein	Homo sapiens	118-122
31382050-7	2019	Here, the NAC part (i.e., alpha-syn(61-95)) responsible for the aggregation was found to change its unstructured conformation in aqueous solution to alpha-helix at the air-water interface by circular dichroism and MAIRS.	nac	10-13	synuclein alpha	Homo sapiens	26-35
31392779-5	2019	Caspase activation is dependent on ROS as shown by the ability of CGs to generate ROS and the ROS-N-acetylcysteine (NAC) relationship, which inhibits apoptosis during cotreatment by preventing the formation of caspase-8 and -3.	nac	116-119	caspase 8	Homo sapiens	210-226
31897310-5	2019	This review focused on the potential effects of chemotherapy on PD-L1 expression and the role of PD-L1 as a prognostic and predictive marker in NAC-treated cancer patients.	nac	144-147	CD274 molecule	Homo sapiens	97-102
31268148-5	2019	We further show that transcript abundance of the NAC domain genes NAC SECONDARY WALL THICKENING PROMOTING FACTOR1 (NST1) and NST2, which have been shown to regulate the secondary cell wall thickenings in the anther endothecium, were dramatically reduced in the amiR-RUS4 floral buds.	nac	49-52	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	115-119
31342395-11	2019	Finally, the expression of CCND1, a cyclin that forms complexes with CDK4/6 to promote the cell cycle, was the most informative feature in pre-NAC biopsies to predict response to NAC.	nac	143-146	cyclin D1	Homo sapiens	27-32
31342395-11	2019	Finally, the expression of CCND1, a cyclin that forms complexes with CDK4/6 to promote the cell cycle, was the most informative feature in pre-NAC biopsies to predict response to NAC.	nac	179-182	cyclin D1	Homo sapiens	27-32
31342395-11	2019	Finally, the expression of CCND1, a cyclin that forms complexes with CDK4/6 to promote the cell cycle, was the most informative feature in pre-NAC biopsies to predict response to NAC.	nac	179-182	cyclin dependent kinase 4	Homo sapiens	69-75
31176611-8	2019	Patients who experienced complete or partial remission after NAC had significantly decreased serum levels of sPD-1 and sPD-L1 compared to patients with a poor response to NAC (P = .019 and .021, respectively).	nac	61-64	spindle apparatus coiled-coil protein 1	Homo sapiens	119-125
31176611-9	2019	CONCLUSION: Serum levels of sPD-1 and sPD-L1 could be used as noninvasive biomarkers for evaluating the malignancy of TNBC before NAC and for predicting the NAC response in TNBC patients.	nac	157-160	spindle apparatus coiled-coil protein 1	Homo sapiens	38-44
31268148-5	2019	We further show that transcript abundance of the NAC domain genes NAC SECONDARY WALL THICKENING PROMOTING FACTOR1 (NST1) and NST2, which have been shown to regulate the secondary cell wall thickenings in the anther endothecium, were dramatically reduced in the amiR-RUS4 floral buds.	nac	49-52	NAC domain protein 66	Arabidopsis thaliana	125-129
31268148-5	2019	We further show that transcript abundance of the NAC domain genes NAC SECONDARY WALL THICKENING PROMOTING FACTOR1 (NST1) and NST2, which have been shown to regulate the secondary cell wall thickenings in the anther endothecium, were dramatically reduced in the amiR-RUS4 floral buds.	nac	49-52	root UVB sensitive protein (Protein of unknown function, DUF647)	Arabidopsis thaliana	266-270
31268148-5	2019	We further show that transcript abundance of the NAC domain genes NAC SECONDARY WALL THICKENING PROMOTING FACTOR1 (NST1) and NST2, which have been shown to regulate the secondary cell wall thickenings in the anther endothecium, were dramatically reduced in the amiR-RUS4 floral buds.	nac	66-69	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	115-119
31268148-5	2019	We further show that transcript abundance of the NAC domain genes NAC SECONDARY WALL THICKENING PROMOTING FACTOR1 (NST1) and NST2, which have been shown to regulate the secondary cell wall thickenings in the anther endothecium, were dramatically reduced in the amiR-RUS4 floral buds.	nac	66-69	NAC domain protein 66	Arabidopsis thaliana	125-129
31268148-5	2019	We further show that transcript abundance of the NAC domain genes NAC SECONDARY WALL THICKENING PROMOTING FACTOR1 (NST1) and NST2, which have been shown to regulate the secondary cell wall thickenings in the anther endothecium, were dramatically reduced in the amiR-RUS4 floral buds.	nac	66-69	root UVB sensitive protein (Protein of unknown function, DUF647)	Arabidopsis thaliana	266-270
31176488-7	2019	Overall, our results provide evidence for the importance of both N-terminal NAC domain and the C-terminal region in regulating the stability of SOG1 protein under salinity stress in vitro.	nac	76-79	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	144-148
31100299-10	2019	Moreover, repeated administrations of ceftriaxone during cocaine-free perios attenuated CPP persistence and normalized GLT-1 level in the NAc.	nac	138-141	solute carrier family 1 member 2	Rattus norvegicus	119-124
30414913-9	2019	CpG-specific methylation in the Maoa promoter was a potential moderator of the interaction of ELS with alcohol consumption on Maoa expression in the NAc.	nac	149-152	monoamine oxidase A	Rattus norvegicus	32-36
30414913-9	2019	CpG-specific methylation in the Maoa promoter was a potential moderator of the interaction of ELS with alcohol consumption on Maoa expression in the NAc.	nac	149-152	monoamine oxidase A	Rattus norvegicus	126-130
31598341-1	2019	Purpose: Neoadjuvant chemotherapy (NAC) is less effective for luminal breast cancer because luminal breast cancer has a lower rate of pathological complete response (pCR) after NAC than human epidermal growth factor receptor 2 (HER2)-type and triple-negative breast cancer (TNBC).	nac	35-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	228-232
31598341-9	2019	In the subgroup analysis of luminal HER2- breast cancer, the multivariate analysis showed that higher Ki67 expression and axilla pCR and BCS conversion rates were significantly associated with tumor response to NAC.	nac	211-214	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-40
31598341-10	2019	Conclusion: Despite the low pCR rate, the tumor response and BCS conversion rates after NAC of luminal HER2- breast cancer were similar to those of other subtypes.	nac	88-91	erb-b2 receptor tyrosine kinase 2	Homo sapiens	103-107
31598341-11	2019	NAC has the potential benefit of reducing the size of breast cancer, thereby increasing the BCS conversion rate in luminal HER2- breast cancer.	nac	0-3	erb-b2 receptor tyrosine kinase 2	Homo sapiens	123-127
31071305-8	2019	A significant increase in Fra-2 immunoreactivity (Fra-2-IR) in the ATN, mPFC (prelimbic area, PrL) and NAc,sh was observed after MK-801, while a different pattern of Fra-2-IR was detected following ATN disinhibition (e.g., increase in DG and NAc,sh, and decrease in PrL cortex).	nac	103-106	FOS like 2, AP-1 transcription factor subunit	Rattus norvegicus	26-31
31071305-8	2019	A significant increase in Fra-2 immunoreactivity (Fra-2-IR) in the ATN, mPFC (prelimbic area, PrL) and NAc,sh was observed after MK-801, while a different pattern of Fra-2-IR was detected following ATN disinhibition (e.g., increase in DG and NAc,sh, and decrease in PrL cortex).	nac	242-245	FOS like 2, AP-1 transcription factor subunit	Rattus norvegicus	26-31
31071305-8	2019	A significant increase in Fra-2 immunoreactivity (Fra-2-IR) in the ATN, mPFC (prelimbic area, PrL) and NAc,sh was observed after MK-801, while a different pattern of Fra-2-IR was detected following ATN disinhibition (e.g., increase in DG and NAc,sh, and decrease in PrL cortex).	nac	242-245	FOS like 2, AP-1 transcription factor subunit	Rattus norvegicus	50-55
31071305-8	2019	A significant increase in Fra-2 immunoreactivity (Fra-2-IR) in the ATN, mPFC (prelimbic area, PrL) and NAc,sh was observed after MK-801, while a different pattern of Fra-2-IR was detected following ATN disinhibition (e.g., increase in DG and NAc,sh, and decrease in PrL cortex).	nac	242-245	FOS like 2, AP-1 transcription factor subunit	Rattus norvegicus	50-55
31351142-10	2019	The observations that fgf mRNA levels were more altered in the dorsal striatum than in the NAc of LgA rats suggest that changes in striatal FGF expression may be more salient to incubation of oxycodone craving than alterations in the NAc.	nac	234-237	fibroblast growth factor 2	Rattus norvegicus	22-25
31326313-10	2019	NAC decreased cofilin phosphorylation and induced a mesenchymal-epithelial transition phenotype.	nac	0-3	cofilin 1	Homo sapiens	14-21
31282647-12	2019	Taken together, this series of studies demonstrate that METH-induced neuroinflammation is, at least in part, mediated by TLR4-IL6 signaling within the VTA, which has the downstream effect of elevating dopamine in the NAc shell.	nac	217-220	toll like receptor 4	Homo sapiens	121-125
31282647-12	2019	Taken together, this series of studies demonstrate that METH-induced neuroinflammation is, at least in part, mediated by TLR4-IL6 signaling within the VTA, which has the downstream effect of elevating dopamine in the NAc shell.	nac	217-220	interleukin 6	Homo sapiens	126-129
31210664-5	2019	Cox-regression showed superior OS in NAC compared with AC and surgery alone (26 vs 23 vs 14 months, P &lt; 0.001).	nac	37-40	cytochrome c oxidase subunit 8A	Homo sapiens	0-3
31109961-6	2019	Using electrophysiology, we showed that both inhibitory and excitatory inputs to VTA dopaminergic neurons projecting to the NAc medial shell were suppressed by the MOR agonists DAMGO and morphine, which caused a shift in the excitatory/inhibitory balance and an increased action potential firing rate.	nac	124-127	opioid receptor, mu 1	Mus musculus	164-167
31372050-10	2019	Good response to NAC was associated with p53 expression.	nac	17-20	tumor protein p53	Homo sapiens	41-44
30915523-9	2019	CONCLUSIONS: Our models predicted that patients with subtype 2 and subtype 3 (HER2+ and triple negative, respectively) are more likely to have a pCR to NAC than those with subtype 1 (luminal).	nac	152-155	erb-b2 receptor tyrosine kinase 2	Homo sapiens	78-82
31389386-11	2019	CONCLUSION: Residual nodal disease after NAC analysed by LNRC or LNR = 0.25 cut-off value, is prognostic and can discriminate between favourable and unfavourable outcomes for TNBC and Her2+ breast cancers.	nac	41-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	184-188
31368573-5	2019	However, with both treatments, levels of ANG II, IL-6, and s-IL-6Ralpha, and activity of JAK1/STAT3 remained high, all of which were normalized by co-administration of NAC or IL-6 neutralizing antibody.	nac	168-171	interleukin 6 receptor	Rattus norvegicus	61-71
31368573-5	2019	However, with both treatments, levels of ANG II, IL-6, and s-IL-6Ralpha, and activity of JAK1/STAT3 remained high, all of which were normalized by co-administration of NAC or IL-6 neutralizing antibody.	nac	168-171	Janus kinase 1	Rattus norvegicus	89-93
31368573-5	2019	However, with both treatments, levels of ANG II, IL-6, and s-IL-6Ralpha, and activity of JAK1/STAT3 remained high, all of which were normalized by co-administration of NAC or IL-6 neutralizing antibody.	nac	168-171	signal transducer and activator of transcription 3	Rattus norvegicus	94-99
31368573-5	2019	However, with both treatments, levels of ANG II, IL-6, and s-IL-6Ralpha, and activity of JAK1/STAT3 remained high, all of which were normalized by co-administration of NAC or IL-6 neutralizing antibody.	nac	168-171	interleukin 6	Rattus norvegicus	61-65
31428569-10	2019	Apoptosis of A549 cells was decreased after transfected with p53 shRNA or treated with reactive oxygen species inhibitor NAC and p38MAPK inhibitor SB203580, suggesting that the p53/ROS/p38MAPK pathway appeared to mediate the LBP-induced apoptosis of A549 cells.	nac	121-124	tumor protein p53	Homo sapiens	61-64
31428569-10	2019	Apoptosis of A549 cells was decreased after transfected with p53 shRNA or treated with reactive oxygen species inhibitor NAC and p38MAPK inhibitor SB203580, suggesting that the p53/ROS/p38MAPK pathway appeared to mediate the LBP-induced apoptosis of A549 cells.	nac	121-124	tumor protein p53	Homo sapiens	177-180
30480814-11	2019	CONCLUSION: HMGB1 and RAGE were involved in the pathogenesis of hyperoxia-induced lung injury, inhalation of NAC might alleviate hyperoxia-induced lung injury by regulating the expression of HMGB1 and RAGE.	nac	109-112	high mobility group box 1	Rattus norvegicus	12-17
30480814-11	2019	CONCLUSION: HMGB1 and RAGE were involved in the pathogenesis of hyperoxia-induced lung injury, inhalation of NAC might alleviate hyperoxia-induced lung injury by regulating the expression of HMGB1 and RAGE.	nac	109-112	advanced glycosylation end product-specific receptor	Rattus norvegicus	22-26
30480814-11	2019	CONCLUSION: HMGB1 and RAGE were involved in the pathogenesis of hyperoxia-induced lung injury, inhalation of NAC might alleviate hyperoxia-induced lung injury by regulating the expression of HMGB1 and RAGE.	nac	109-112	high mobility group box 1	Rattus norvegicus	191-196
30480814-11	2019	CONCLUSION: HMGB1 and RAGE were involved in the pathogenesis of hyperoxia-induced lung injury, inhalation of NAC might alleviate hyperoxia-induced lung injury by regulating the expression of HMGB1 and RAGE.	nac	109-112	advanced glycosylation end product-specific receptor	Rattus norvegicus	201-205
30997706-6	2019	In the IHC analysis, the proportions of CD8+ T lymphocytes, PNAd+ high endothelial venules, CD163+ macrophages and Ki-67+ cells within the TLO were higher in the NAC group than in the SF group.	nac	162-165	N-terminal asparagine amidase	Homo sapiens	60-64
30623554-2	2019	PATIENTS AND METHODS: We reviewed 201 patients treated with NAC and RC for cT2-cT4N0M0 BC between 01/1999 and 01/2015.	nac	60-63	solute carrier family 6 member 10, pseudogene	Homo sapiens	75-78
31267907-1	2019	The purpose of this meta-analysis was to determine the value of quantitative dynamic contrast-enhanced (DCE) MRI (DCE-MRI) in evaluating the response of breast cancer to neoadjuvant chemotherapy (NAC).	nac	196-199	cell cycle regulator of NHEJ	Homo sapiens	114-121
31267907-3	2019	The sensitivities and specificities of quantitative DCE-MRI in the evaluation of NAC for breast cancer were extracted from the articles.	nac	81-84	cell cycle regulator of NHEJ	Homo sapiens	52-59
31267907-6	2019	The sensitivity and specificity in the included 14 articles of quantitative DCE-MRI (Ktrans, Kep, and ve) in comprehensively evaluating NAC for breast cancer were 84 per cent (95% confidence interval (CI): 78-88%) and 83 per cent (95% CI: 79-86%), respectively.	nac	136-139	cell cycle regulator of NHEJ	Homo sapiens	76-83
31267907-10	2019	Our study confirmed that the quantitative DCE-MRI is able to monitor NAC treatment for breast cancer because of its high sensitivity and specificity.	nac	69-72	cell cycle regulator of NHEJ	Homo sapiens	42-49
30965051-7	2019	Additionally, PI3K/Akt and ROS were also involved in Sulforaphane-induced Nrf2 activation and HO-1 expression, as revealed by the pharmacological inhibitors LY294002 and NAC.	nac	170-173	heme oxygenase 1	Mus musculus	94-98
30868392-8	2019	CONCLUSIONS: Strong baseline tumor infiltration with CD8+ T-cells in the presence of tumoral HLA class 1 expression in patients with HER2-negative breast cancer is related to a higher pCR rate and a better DFS after NAC.	nac	216-219	CD8a molecule	Homo sapiens	53-56
30868392-8	2019	CONCLUSIONS: Strong baseline tumor infiltration with CD8+ T-cells in the presence of tumoral HLA class 1 expression in patients with HER2-negative breast cancer is related to a higher pCR rate and a better DFS after NAC.	nac	216-219	erb-b2 receptor tyrosine kinase 2	Homo sapiens	133-137
30997706-6	2019	In the IHC analysis, the proportions of CD8+ T lymphocytes, PNAd+ high endothelial venules, CD163+ macrophages and Ki-67+ cells within the TLO were higher in the NAC group than in the SF group.	nac	162-165	CD163 molecule	Homo sapiens	92-97
30959186-6	2019	The purpose of this article was a reviewing of medical literature regarding possible indications for SLN detection and axillary dissection in patients with NAC according to sentinel lymph node status.	nac	156-159	sarcolipin	Homo sapiens	101-104
30959186-9	2019	It is important to include patients in the trials to make recommendations progress on SLN after NAC and avoid a rate of uninjured AD.	nac	96-99	sarcolipin	Homo sapiens	86-89
30924571-9	2019	In the summed spectrum after the first cycle of NAC, PME/Pi and PME/PDE decreased by 18 and 13%, respectively.	nac	48-51	cystatin B	Homo sapiens	53-56
30707342-14	2019	CONCLUSIONS: Analysis of a national tumor registry suggests a lack of overall survival benefit for NAC with localized, muscle invasive SCC of the bladder.	nac	99-102	serpin family B member 3	Homo sapiens	135-138
30126858-7	2019	Univariable and multivariable analyses revealed that the relative change in VEGF prior to the third cycle of NAC had a remarkable predictive value for both pCR and pathological nonresponse with high sensitivity and specificity.	nac	109-112	vascular endothelial growth factor A	Homo sapiens	76-80
30126858-9	2019	CONCLUSION: Our findings indicate that monitoring serum VEGF could help identify patients with different responses at an early time point of NAC and at varying risk of disease relapse.	nac	141-144	vascular endothelial growth factor A	Homo sapiens	56-60
30126858-10	2019	Serum VEGF may also serve as an alternative to traditional response-evaluating methodologies in tailoring and modifying the NAC strategy for both operable and advanced TNBCs.	nac	124-127	vascular endothelial growth factor A	Homo sapiens	6-10
30126858-13	2019	Results of this study indicate that the monitoring of serum vascular endothelial growth factor (VEGF) could identify patients with favorable or poor responses at an early time point of NAC.	nac	185-188	vascular endothelial growth factor A	Homo sapiens	60-94
30126858-13	2019	Results of this study indicate that the monitoring of serum vascular endothelial growth factor (VEGF) could identify patients with favorable or poor responses at an early time point of NAC.	nac	185-188	vascular endothelial growth factor A	Homo sapiens	96-100
30924571-9	2019	In the summed spectrum after the first cycle of NAC, PME/Pi and PME/PDE decreased by 18 and 13%, respectively.	nac	48-51	aldehyde dehydrogenase 7 family member A1	Homo sapiens	68-71
30952428-7	2019	NAC treatment not only reduced the levels of cytoplasmic and nuclear Foxo1, but also inhibited GRK2 expression and autophagy, remarkably reducing high glucose-induced apoptosis.	nac	0-3	forkhead box O1	Rattus norvegicus	69-74
31151151-4	2019	We hypothesized that ER-positive BC with high expression of AR will have fewer TILs and an inferior response to NAC, but with a better prognosis.	nac	112-115	estrogen receptor 1	Homo sapiens	21-23
31151151-4	2019	We hypothesized that ER-positive BC with high expression of AR will have fewer TILs and an inferior response to NAC, but with a better prognosis.	nac	112-115	androgen receptor	Homo sapiens	60-62
31151151-9	2019	Finally, AR high tumors had a significantly lower rate of attaining pathological complete response to NAC (GSE22358), but better survival.	nac	102-105	androgen receptor	Homo sapiens	9-11
31151151-10	2019	In conclusion, our results demonstrated that high AR has fewer tumor infiltrating lymphocytes as well as cytolytic activity and an inferior response to NAC, but better survival in ER-positive BC.	nac	152-155	androgen receptor	Homo sapiens	50-52
30952428-7	2019	NAC treatment not only reduced the levels of cytoplasmic and nuclear Foxo1, but also inhibited GRK2 expression and autophagy, remarkably reducing high glucose-induced apoptosis.	nac	0-3	G protein-coupled receptor kinase 2	Rattus norvegicus	95-99
31106153-6	2019	Kaplan-Meier analysis indicated that patients who received NAC cycles and their excised tumors remained with high levels of NRP-1 had a lower overall survival compared with patients whose tissue NRP-1 decreased post-NAC (log-rank p = 0.049).	nac	59-62	neuropilin 1	Homo sapiens	124-129
31064392-9	2019	In the wild-type BRCA group, patients who received NAC as the primary treatment had shorter PFS compared to those who received primary debulking surgery (PDS) (median, 14.2 vs. 16.9 months, P = 0.003).	nac	51-54	BRCA1 DNA repair associated	Homo sapiens	17-21
31064392-12	2019	Prognosis after NAC was different according to the BRCA mutational status.	nac	16-19	BRCA1 DNA repair associated	Homo sapiens	51-55
30666563-10	2019	Among cN0 patients, TN and HER2 + subtypes would benefit more from axillary de-escalating surgery after NAC than HR+/HER2- subtype.	nac	104-107	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-31
31067777-5	2019	The proportion of FBXW7-positive cells in surgically resected CRC specimens from patients who underwent NAC or NACRT was significantly higher than that in the pre-treatment biopsy specimens (p &lt; 0.001).	nac	104-107	F-box and WD repeat domain containing 7	Homo sapiens	18-23
31106153-3	2019	To further identify the role of NRP-1 and its interacting molecules in correspondence with patients" response to neoadjuvant chemotherapy (NAC), we conducted a comparative study on blood and tissue samples collected from a cohort of locally advanced breast cancer patients, before and after neoadjuvant chemotherapy (NAC).	nac	139-142	neuropilin 1	Homo sapiens	32-37
31106153-6	2019	Kaplan-Meier analysis indicated that patients who received NAC cycles and their excised tumors remained with high levels of NRP-1 had a lower overall survival compared with patients whose tissue NRP-1 decreased post-NAC (log-rank p = 0.049).	nac	216-219	neuropilin 1	Homo sapiens	195-200
31106153-7	2019	In vitro validation of the former result showed an increase in the secreted and cellular NRP-1 levels in resistant MDA-MB-231 cells to the most common NAC regimen Adriyamicin/cyclophosphamide+Paclitaxel (AC+PAC).	nac	151-154	neuropilin 1	Homo sapiens	89-94
31106153-4	2019	From a panel of tested proteins and genes, we found that the levels of plasma NRP-1, placenta growth factor (PlGF) and immune cell expression of the transcription factor SNAI1 before and after NAC were significantly different.	nac	193-196	snail family transcriptional repressor 1	Homo sapiens	170-175
31106153-5	2019	Paired t-test analysis of 22 locally advanced breast cancer patients showed that plasma NRP-1 levels were increased significantly (p = 0.018) post-NAC in patients with pathological partial response (pPR).	nac	147-150	neuropilin 1	Homo sapiens	88-93
31106153-5	2019	Paired t-test analysis of 22 locally advanced breast cancer patients showed that plasma NRP-1 levels were increased significantly (p = 0.018) post-NAC in patients with pathological partial response (pPR).	nac	147-150	PPR1	Homo sapiens	199-202
31106153-11	2019	We conclude that increased plasma and tissue NRP-1 post-NAC correlate with pPR and shorter overall survival, respectively.	nac	56-59	neuropilin 1	Homo sapiens	45-50
31106153-11	2019	We conclude that increased plasma and tissue NRP-1 post-NAC correlate with pPR and shorter overall survival, respectively.	nac	56-59	PPR1	Homo sapiens	75-78
31002322-7	2019	The association of this signature with pathologic complete response was explored in 2 patient cohorts from different institutions, where all patients received HER2-targeted NAC (n = 28, n = 50).	nac	173-176	erb-b2 receptor tyrosine kinase 2	Homo sapiens	159-163
31040895-21	2019	CONCLUSION: A non-radiological response and a number of NAC sessions &gt; 7 are the two most pertinent predictive factors of non-histological response (TRG 4 or 5).	nac	56-59	tRNA-Gly (anticodon CCC) 2-2	Homo sapiens	152-157
31002322-10	2019	Main Outcomes and Measures: Evaluation of imaging signatures by the area under the receiver operating characteristic curve (AUC) in identifying HER2+ molecular subtypes and distinguishing pathologic complete response (ypT0/is) to NAC with HER2-targeting.	nac	230-233	erb-b2 receptor tyrosine kinase 2	Homo sapiens	239-243
30714803-2	2019	We tested three compounds with beta-lactam rings for their ability to attenuate cue-primed reinstatement and increase GLT-1 and xCT expression in the NAc and prefrontal cortex (PFC).	nac	150-153	solute carrier family 1 member 2	Rattus norvegicus	118-123
30714803-12	2019	Furthermore, the upregulation of both GLT-1 and xCT in the NAc may be needed to attenuate cocaine seeking.	nac	59-62	solute carrier family 1 member 2	Rattus norvegicus	38-43
30064200-9	2019	Positive tumor PD-L1 expression (H-score &gt;= 5) in baseline or post- NAC tissue was associated to superior DFS (57.6 months vs. 12.5 months, p=0.001 and 53.3 months vs. 18.9 months, p=0.040).	nac	71-74	CD274 molecule	Homo sapiens	15-20
30659433-9	2019	Generally lower concordance rates for ER, PR and HER2 were observed in the NAC cohort.	nac	75-78	estrogen receptor 1	Homo sapiens	38-40
30659433-9	2019	Generally lower concordance rates for ER, PR and HER2 were observed in the NAC cohort.	nac	75-78	progesterone receptor	Homo sapiens	42-44
30659433-9	2019	Generally lower concordance rates for ER, PR and HER2 were observed in the NAC cohort.	nac	75-78	erb-b2 receptor tyrosine kinase 2	Homo sapiens	49-53
30064200-12	2019	Baseline PD-L1 expression and changes of PD-L1 expression in tumor tissue during NAC also showed association to prognosis.	nac	81-84	CD274 molecule	Homo sapiens	41-46
30337203-1	2019	AIMS: We evaluated the prognostic significance of postoperative re-elevation of cancer antigen-125 (CA-125) levels in patients with ovarian cancer and preoperative normalization of CA-125 levels after neoadjuvant chemotherapy (NAC).	nac	227-230	mucin 16, cell surface associated	Homo sapiens	181-187
30776175-7	2019	PIK3CA mutation (P = 0.040 for ypT0/isypN0) and CCND2 amplification (P = 0.042 for ypT0/is) showed reduced sensitivity to NAC.	nac	122-125	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	0-6
30776175-7	2019	PIK3CA mutation (P = 0.040 for ypT0/isypN0) and CCND2 amplification (P = 0.042 for ypT0/is) showed reduced sensitivity to NAC.	nac	122-125	cyclin D2	Homo sapiens	48-53
30673828-8	2019	A Grade 2 or higher effect of NAC was associated with high pre-NAC cytotoxic T lymphocyte-associated protein 4 (CTLA-4) levels (p = 0.0281) and elevated post-NAC NK (p = 0.0005) cells and transforming growth factor-beta (TGF-beta; p = 0.0350) levels.	nac	30-33	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	112-118
29907842-3	2019	Consummatory behavior is regulated by the medial shell (mSh) of the accumbens nucleus (Nac) through direct connections with the rostral part of the lateral hypothalamic area (LHA).	nac	87-90	msh homeobox 1	Mus musculus	56-59
29907842-7	2019	Sweet condensed milk (SCM) served as a reward to test consumption and subsequent activation (Fos+) of Nac and LHA neurons.	nac	102-105	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	93-96
29907842-10	2019	RESULTS: A group of food reward-representing D1R+ neurons was identified in the mSh-Nac.	nac	84-87	msh homeobox 1	Mus musculus	80-83
29907842-13	2019	Hyperphagic PR rats showed increased intake of SCM, reduced D1R expression, and an impaired response to SCM-evoked neuronal activation in the mSh-Nac, accompanied by an elevated number of Fos+ neurons in the LHA compared to controls.	nac	146-149	msh homeobox 1	Mus musculus	142-145
29907842-14	2019	CONCLUSIONS: Sensitivity of food reward-representing neurons in the mSh-Nac determines the level of satisfaction that governs cessation of consumption, probably through connections with the LHA.	nac	72-75	msh homeobox 1	Mus musculus	68-71
30209686-2	2019	NAC infiltration in OBC suggests that RAC1, RHOA and CXCR4 proteins are risk factors for migration and infiltration of OBC to NAC.	nac	0-3	Rac family small GTPase 1	Homo sapiens	38-42
30520096-1	2019	Neoadjuvant chemotherapy (NAC) is the major preoperative treatment of breast cancer (BC) with negative human epidermal growth factor receptor 2 (HER2), and the efficacy of NAC and the optimization of regimen are under intensive research.	nac	26-29	erb-b2 receptor tyrosine kinase 2	Homo sapiens	109-143
30520096-1	2019	Neoadjuvant chemotherapy (NAC) is the major preoperative treatment of breast cancer (BC) with negative human epidermal growth factor receptor 2 (HER2), and the efficacy of NAC and the optimization of regimen are under intensive research.	nac	26-29	erb-b2 receptor tyrosine kinase 2	Homo sapiens	145-149
30520096-2	2019	The current study aimed to define the predictive biomarkers for paclitaxel (PTX) response in NAC of HER2-negative BC.	nac	93-96	erb-b2 receptor tyrosine kinase 2	Homo sapiens	100-104
29808599-3	2019	Members of the NAC (NAM, ATAF1/2 and CUC) family of transcription factors are described as top level regulators of xylem cell fate and secondary cell wall (SCW) deposition, but the signals initiating their transcription have yet to be elucidated.	nac	15-18	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	20-23
29808599-3	2019	Members of the NAC (NAM, ATAF1/2 and CUC) family of transcription factors are described as top level regulators of xylem cell fate and secondary cell wall (SCW) deposition, but the signals initiating their transcription have yet to be elucidated.	nac	15-18	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	25-40
30702971-15	2019	COX-2 inhibitors should preferably be avoided during docetaxel use in patients with breast cancer who are undergoing NAC.	nac	117-120	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
30806711-2	2019	NAC SECONDARY WALL THICKENING PROMOTING FACTOR3/SECONDARY WALL-ASSOCIATED NAC DOMAIN PROTEIN 1 (NST3/SND1) and NST1 were identified as master regulators of SCW formation in xylem fiber cells in the model plant Arabidopsis thaliana.	nac	0-3	NAC domain containing protein 12	Arabidopsis thaliana	96-100
30806711-2	2019	NAC SECONDARY WALL THICKENING PROMOTING FACTOR3/SECONDARY WALL-ASSOCIATED NAC DOMAIN PROTEIN 1 (NST3/SND1) and NST1 were identified as master regulators of SCW formation in xylem fiber cells in the model plant Arabidopsis thaliana.	nac	0-3	NAC domain containing protein 12	Arabidopsis thaliana	101-105
30806711-2	2019	NAC SECONDARY WALL THICKENING PROMOTING FACTOR3/SECONDARY WALL-ASSOCIATED NAC DOMAIN PROTEIN 1 (NST3/SND1) and NST1 were identified as master regulators of SCW formation in xylem fiber cells in the model plant Arabidopsis thaliana.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	111-115
30923569-13	2019	NAC involvement was more likely in Estrogen receptor (ER) and Progesterone receptor (PR) patients than in ER+ and PR+ patients (p = 0.000), while Human epidermal receptor (HER+) patients were more likely to have NAC involvement than HER patients (p = 0.000).	nac	0-3	estrogen receptor 1	Homo sapiens	35-52
30923569-13	2019	NAC involvement was more likely in Estrogen receptor (ER) and Progesterone receptor (PR) patients than in ER+ and PR+ patients (p = 0.000), while Human epidermal receptor (HER+) patients were more likely to have NAC involvement than HER patients (p = 0.000).	nac	0-3	estrogen receptor 1	Homo sapiens	54-56
30923569-13	2019	NAC involvement was more likely in Estrogen receptor (ER) and Progesterone receptor (PR) patients than in ER+ and PR+ patients (p = 0.000), while Human epidermal receptor (HER+) patients were more likely to have NAC involvement than HER patients (p = 0.000).	nac	0-3	progesterone receptor	Homo sapiens	62-83
30923569-13	2019	NAC involvement was more likely in Estrogen receptor (ER) and Progesterone receptor (PR) patients than in ER+ and PR+ patients (p = 0.000), while Human epidermal receptor (HER+) patients were more likely to have NAC involvement than HER patients (p = 0.000).	nac	0-3	progesterone receptor	Homo sapiens	85-87
30923569-13	2019	NAC involvement was more likely in Estrogen receptor (ER) and Progesterone receptor (PR) patients than in ER+ and PR+ patients (p = 0.000), while Human epidermal receptor (HER+) patients were more likely to have NAC involvement than HER patients (p = 0.000).	nac	0-3	estrogen receptor 1	Homo sapiens	106-108
30923569-13	2019	NAC involvement was more likely in Estrogen receptor (ER) and Progesterone receptor (PR) patients than in ER+ and PR+ patients (p = 0.000), while Human epidermal receptor (HER+) patients were more likely to have NAC involvement than HER patients (p = 0.000).	nac	0-3	progesterone receptor	Homo sapiens	114-116
30871211-8	2019	Crucially, tolerant line YE8112 drought-responsive genes were predominantly implicated in stress signal transduction; cellular redox homeostasis maintenance; MYB, NAC, WRKY, and PLATZ transcriptional factor modulated; carbohydrate synthesis and cell-wall remodeling; amino acid biosynthesis; and protein ubiquitination processes.	nac	163-166	WRKY transcription factor WRKY76	Zea mays	168-172
30209686-2	2019	NAC infiltration in OBC suggests that RAC1, RHOA and CXCR4 proteins are risk factors for migration and infiltration of OBC to NAC.	nac	126-129	ras homolog family member A	Homo sapiens	44-48
30209686-2	2019	NAC infiltration in OBC suggests that RAC1, RHOA and CXCR4 proteins are risk factors for migration and infiltration of OBC to NAC.	nac	126-129	C-X-C motif chemokine receptor 4	Homo sapiens	53-58
30209686-8	2019	CONCLUSION: We conclude that the expression of the RAC1, RHOA, and CXCR4 proteins and their interactions play a role as risk factors of NAC infiltration.	nac	136-139	Rac family small GTPase 1	Homo sapiens	51-55
30209686-8	2019	CONCLUSION: We conclude that the expression of the RAC1, RHOA, and CXCR4 proteins and their interactions play a role as risk factors of NAC infiltration.	nac	136-139	ras homolog family member A	Homo sapiens	57-61
30209686-8	2019	CONCLUSION: We conclude that the expression of the RAC1, RHOA, and CXCR4 proteins and their interactions play a role as risk factors of NAC infiltration.	nac	136-139	C-X-C motif chemokine receptor 4	Homo sapiens	67-72
30209686-2	2019	NAC infiltration in OBC suggests that RAC1, RHOA and CXCR4 proteins are risk factors for migration and infiltration of OBC to NAC.	nac	0-3	ras homolog family member A	Homo sapiens	44-48
30209686-2	2019	NAC infiltration in OBC suggests that RAC1, RHOA and CXCR4 proteins are risk factors for migration and infiltration of OBC to NAC.	nac	0-3	C-X-C motif chemokine receptor 4	Homo sapiens	53-58
30639279-0	2019	Downregulated spinal IRF8 and BDNF in NAC are involved in neuropathic pain-induced depression relief via pulsed radiofrequency on dorsal root ganglion in rat SNI model.	nac	38-41	interferon regulatory factor 8	Rattus norvegicus	21-25
30209686-2	2019	NAC infiltration in OBC suggests that RAC1, RHOA and CXCR4 proteins are risk factors for migration and infiltration of OBC to NAC.	nac	126-129	Rac family small GTPase 1	Homo sapiens	38-42
30639279-0	2019	Downregulated spinal IRF8 and BDNF in NAC are involved in neuropathic pain-induced depression relief via pulsed radiofrequency on dorsal root ganglion in rat SNI model.	nac	38-41	brain-derived neurotrophic factor	Rattus norvegicus	30-34
31128000-10	2019	While there was no difference in the relative expression of ANXA3 between the two groups before chemotherapy, the relative expression of ANXA3 in the TEC group was lower than that in the CEF group after NAC (p&lt;0.05).	nac	203-206	annexin A3	Homo sapiens	137-142
30639279-6	2019	Meanwhile, Western blot, immunohistochemistry, and RT-PCR revealed that PRF on DRG or intrathecal injection of IRF8 siRNA inhibited IRF8 overexpression in the spinal cord and brain-derived neurotrophic factor (BDNF) in NAc.	nac	219-222	interferon regulatory factor 8	Rattus norvegicus	111-115
30639279-8	2019	The suppressed overexpression of the spinal IRF8 and BDNF in NAc may play an important role and contribute considerably to effectiveness of the therapy by PRF on DRG.	nac	61-64	interferon regulatory factor 8	Rattus norvegicus	44-48
30639279-8	2019	The suppressed overexpression of the spinal IRF8 and BDNF in NAc may play an important role and contribute considerably to effectiveness of the therapy by PRF on DRG.	nac	61-64	brain-derived neurotrophic factor	Rattus norvegicus	53-57
30085020-8	2019	These results all indicated that the PD-L1 status of carcinoma cells in metastatic lymph nodes and the FOXP3/CD8 ratio in primary tumors could predict eventual clinical outcomes in ESCC patients with NAC.	nac	200-203	CD274 molecule	Homo sapiens	37-42
30085020-8	2019	These results all indicated that the PD-L1 status of carcinoma cells in metastatic lymph nodes and the FOXP3/CD8 ratio in primary tumors could predict eventual clinical outcomes in ESCC patients with NAC.	nac	200-203	forkhead box P3	Homo sapiens	103-108
30085020-8	2019	These results all indicated that the PD-L1 status of carcinoma cells in metastatic lymph nodes and the FOXP3/CD8 ratio in primary tumors could predict eventual clinical outcomes in ESCC patients with NAC.	nac	200-203	CD8a molecule	Homo sapiens	109-112
31128000-12	2019	CONCLUSION: Compared with CEF regimen, NAC with TEC regimen can improve the clinical and pathological effectiveness rate, inhibit the expression of ANXA3, and improve the prognosis of patients, thus having a certain application prospect in NAC.	nac	39-42	tec protein tyrosine kinase	Homo sapiens	48-51
31128000-12	2019	CONCLUSION: Compared with CEF regimen, NAC with TEC regimen can improve the clinical and pathological effectiveness rate, inhibit the expression of ANXA3, and improve the prognosis of patients, thus having a certain application prospect in NAC.	nac	39-42	annexin A3	Homo sapiens	148-153
31128000-12	2019	CONCLUSION: Compared with CEF regimen, NAC with TEC regimen can improve the clinical and pathological effectiveness rate, inhibit the expression of ANXA3, and improve the prognosis of patients, thus having a certain application prospect in NAC.	nac	240-243	tec protein tyrosine kinase	Homo sapiens	48-51
30786857-9	2019	We chose to functionally characterize the NAC (NAM/ATAF1/2/CUC2)-family TF GmNAC42-1 that was annotated as an SAR gene and a homolog of the Arabidopsis thaliana (Arabidopsis) indole alkaloid phytoalexin regulator ANAC042.	nac	42-45	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	47-50
30503889-7	2019	RESULTS: Patients with SCC had a better response to NAC (median percentage of viable tumor: SCC versus ADC, 40% versus 60%; p = 0.027).	nac	52-55	serpin family B member 3	Homo sapiens	23-26
30503889-7	2019	RESULTS: Patients with SCC had a better response to NAC (median percentage of viable tumor: SCC versus ADC, 40% versus 60%; p = 0.027).	nac	52-55	serpin family B member 3	Homo sapiens	92-95
30503889-11	2019	CONCLUSIONS: In response to NAC, the optimal cutoff percentage of viable tumor for predicting survival differs between ADC and SCC.	nac	28-31	serpin family B member 3	Homo sapiens	127-130
30786857-9	2019	We chose to functionally characterize the NAC (NAM/ATAF1/2/CUC2)-family TF GmNAC42-1 that was annotated as an SAR gene and a homolog of the Arabidopsis thaliana (Arabidopsis) indole alkaloid phytoalexin regulator ANAC042.	nac	42-45	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	51-58
30786857-9	2019	We chose to functionally characterize the NAC (NAM/ATAF1/2/CUC2)-family TF GmNAC42-1 that was annotated as an SAR gene and a homolog of the Arabidopsis thaliana (Arabidopsis) indole alkaloid phytoalexin regulator ANAC042.	nac	42-45	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	59-63
30786857-9	2019	We chose to functionally characterize the NAC (NAM/ATAF1/2/CUC2)-family TF GmNAC42-1 that was annotated as an SAR gene and a homolog of the Arabidopsis thaliana (Arabidopsis) indole alkaloid phytoalexin regulator ANAC042.	nac	42-45	NAC domain containing protein 42	Arabidopsis thaliana	213-220
30774927-8	2019	Despite the high inter-patient heterogeneity, we identified that stem cell quiescence-associated genes ALDH1L1, HOPX, WNT5A and SOX9 were convergently hypomethylated across all the samples after NAC treatment.	nac	195-198	aldehyde dehydrogenase 1 family member L1	Homo sapiens	103-110
30774927-8	2019	Despite the high inter-patient heterogeneity, we identified that stem cell quiescence-associated genes ALDH1L1, HOPX, WNT5A and SOX9 were convergently hypomethylated across all the samples after NAC treatment.	nac	195-198	HOP homeobox	Homo sapiens	112-116
30774927-8	2019	Despite the high inter-patient heterogeneity, we identified that stem cell quiescence-associated genes ALDH1L1, HOPX, WNT5A and SOX9 were convergently hypomethylated across all the samples after NAC treatment.	nac	195-198	SRY-box transcription factor 9	Homo sapiens	128-132
30774927-10	2019	Conclusions: Our study has revealed that NAC dramatically alters epigenetic heterogeneity in breast cancer and induces convergent hypomethylation of stem cell quiescence-associated genes, ALDH1L1, HOPX, WNT5A and SOX9, which can potentially be developed as therapeutic targets or biomarkers for chemoresistance.	nac	41-44	aldehyde dehydrogenase 1 family member L1	Homo sapiens	188-195
30774927-10	2019	Conclusions: Our study has revealed that NAC dramatically alters epigenetic heterogeneity in breast cancer and induces convergent hypomethylation of stem cell quiescence-associated genes, ALDH1L1, HOPX, WNT5A and SOX9, which can potentially be developed as therapeutic targets or biomarkers for chemoresistance.	nac	41-44	HOP homeobox	Homo sapiens	197-201
30774927-10	2019	Conclusions: Our study has revealed that NAC dramatically alters epigenetic heterogeneity in breast cancer and induces convergent hypomethylation of stem cell quiescence-associated genes, ALDH1L1, HOPX, WNT5A and SOX9, which can potentially be developed as therapeutic targets or biomarkers for chemoresistance.	nac	41-44	Wnt family member 5A	Homo sapiens	203-208
30774927-10	2019	Conclusions: Our study has revealed that NAC dramatically alters epigenetic heterogeneity in breast cancer and induces convergent hypomethylation of stem cell quiescence-associated genes, ALDH1L1, HOPX, WNT5A and SOX9, which can potentially be developed as therapeutic targets or biomarkers for chemoresistance.	nac	41-44	SRY-box transcription factor 9	Homo sapiens	213-217
30348601-7	2019	As compared to "primary BCS", the IMR of "BCS after NAC" is higher for cT1 (12,3% versus 8,3%; p &lt; 0.005), equal for cT2 (14% versus 14%; p = 0.046) and lower for cT3 breast cancer (28,3% versus 31%; p &lt; 0.005).	nac	52-55	cardiotrophin 1	Homo sapiens	71-74
30733496-1	2019	Predictive utility of tumor-infiltrating lymphocytes (TILs) in HER2-positive breast cancer patients receiving neoadjuvant chemotherapy (NAC) with concurrent trastuzumab remains unclear.	nac	136-139	erb-b2 receptor tyrosine kinase 2	Homo sapiens	63-67
30733496-3	2019	This cohort study included 128 HER2-positive breast cancer who received NAC with trastuzumab.	nac	72-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	31-35
30348601-10	2019	This nationwide data confirms that "BCS after NAC" compared to "primary BCS" leads to equal surgical outcomes for cT2 and improved surgical outcomes for cT3 breast cancer.	nac	46-49	cancer/testis antigen 2	Homo sapiens	114-117
30348601-10	2019	This nationwide data confirms that "BCS after NAC" compared to "primary BCS" leads to equal surgical outcomes for cT2 and improved surgical outcomes for cT3 breast cancer.	nac	46-49	cancer antigen 1	Homo sapiens	153-156
30633152-4	2019	The positive rate of HER2 decreased from 42.0% before NAC to 32.1% after NAC (P = .04).	nac	54-57	erb-b2 receptor tyrosine kinase 2	Homo sapiens	21-25
30623878-1	2019	NAC (NAM, ATAF1/2 and CUC2) proteins are key regulators of various plant stress tolerances.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	5-8
30623878-1	2019	NAC (NAM, ATAF1/2 and CUC2) proteins are key regulators of various plant stress tolerances.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	10-17
30623878-1	2019	NAC (NAM, ATAF1/2 and CUC2) proteins are key regulators of various plant stress tolerances.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	22-26
30339245-3	2019	We investigated the frequency of HER2 IHC-/ISH+ BCs and their response to anti-HER2 neoadjuvant chemotherapy (NAC).	nac	110-113	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-83
30632799-11	2019	RESULTS: In the NAC, acute tramadol exposure increases the levels of MOR and p-CREB.	nac	16-19	cAMP responsive element binding protein 1	Rattus norvegicus	79-83
30306430-5	2019	RESULTS: The status of vimentin and increasing labeling index (LI) of TopoIIalpha and KI67 in biopsy specimens were significantly associated with those who responded to NAC treatment.	nac	169-172	vimentin	Homo sapiens	23-31
30324273-8	2019	The association between high pre-NAC TIL levels and significantly increased pCR rate was also confirmed in HER2-positive BC patients treated with a TCHP regimen.	nac	33-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	107-111
30324273-10	2019	CONCLUSIONS: High pre-NAC TIL levels were significantly predictive of pCR in BC, and can act as a surrogate marker for predicting therapeutic effects of a TCHP regimen for HER2-positive BC.	nac	22-25	erb-b2 receptor tyrosine kinase 2	Homo sapiens	172-176
30633152-4	2019	The positive rate of HER2 decreased from 42.0% before NAC to 32.1% after NAC (P = .04).	nac	73-76	erb-b2 receptor tyrosine kinase 2	Homo sapiens	21-25
30633152-5	2019	The positive rate of ER decreased from 66.1% before NAC to 56.2% after NAC (P = .04).	nac	52-55	estrogen receptor 1	Homo sapiens	21-23
30633152-5	2019	The positive rate of ER decreased from 66.1% before NAC to 56.2% after NAC (P = .04).	nac	71-74	estrogen receptor 1	Homo sapiens	21-23
30633152-9	2019	The BMI greater or equal to 24 (P = .004), number of metastatic lymph nodes greater or equal to 1 (P = .029) and TNM stages I-II (P = .008) were statistically associated with change of HER2 (positive to negative).In patients without pCR, NAC leads to changes in Ki-67, HER2, and hormone receptor (HR) expression.	nac	238-241	erb-b2 receptor tyrosine kinase 2	Homo sapiens	185-189
30588320-1	2018	Ripening of the model fruit tomato (Solanum lycopersicum) is controlled by a transcription factor network including NAC (NAM, ATAF1/2, and CUC2) domain proteins such as No-ripening (NOR), SlNAC1, and SlNAC4, but very little is known about the NAC targets or how they regulate ripening.	nac	116-119	NO APICAL MERISTEM	Solanum lycopersicum	121-124
30627134-6	2018	The wall thickening activator proteins NAC SECONDARY WALL THICKENING PROMOTING FACTOR2 (NST2) and NST3 exhibited a decrease in binding with the CESA4Sha promoter with a tracheary element-regulating cis-element (TERE) polymorphism.	nac	39-42	NAC domain protein 66	Arabidopsis thaliana	88-92
30627134-6	2018	The wall thickening activator proteins NAC SECONDARY WALL THICKENING PROMOTING FACTOR2 (NST2) and NST3 exhibited a decrease in binding with the CESA4Sha promoter with a tracheary element-regulating cis-element (TERE) polymorphism.	nac	39-42	NAC domain containing protein 12	Arabidopsis thaliana	98-102
30588320-1	2018	Ripening of the model fruit tomato (Solanum lycopersicum) is controlled by a transcription factor network including NAC (NAM, ATAF1/2, and CUC2) domain proteins such as No-ripening (NOR), SlNAC1, and SlNAC4, but very little is known about the NAC targets or how they regulate ripening.	nac	116-119	NAC domain protein	Solanum lycopersicum	188-194
30588320-1	2018	Ripening of the model fruit tomato (Solanum lycopersicum) is controlled by a transcription factor network including NAC (NAM, ATAF1/2, and CUC2) domain proteins such as No-ripening (NOR), SlNAC1, and SlNAC4, but very little is known about the NAC targets or how they regulate ripening.	nac	190-193	NO APICAL MERISTEM	Solanum lycopersicum	121-124
30631351-7	2018	In addition, water extract of Phaleria macrocarpa and NAC significantly reduced the levels of MDA, TNF-alpha, and TGF-beta 1 as well as increasing the ratio of GSH/GSSG.	nac	54-57	tumor necrosis factor	Rattus norvegicus	99-108
30194511-1	2018	PURPOSE: This study aimed to develop mathematical tools to predict the likelihood of recurrence after neoadjuvant chemotherapy (NAC) plus trastuzumab in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer.	nac	128-131	erb-b2 receptor tyrosine kinase 2	Homo sapiens	173-207
30194511-1	2018	PURPOSE: This study aimed to develop mathematical tools to predict the likelihood of recurrence after neoadjuvant chemotherapy (NAC) plus trastuzumab in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer.	nac	128-131	erb-b2 receptor tyrosine kinase 2	Homo sapiens	209-213
30194511-11	2018	CONCLUSIONS: The DFS and BM models have a high accuracy to predict prognosis among HER2-positive patients treated with NAC plus trastuzumab.	nac	119-122	erb-b2 receptor tyrosine kinase 2	Homo sapiens	83-87
30466589-1	2018	NAC (NAM, ATAF1/2 and CUC2) transcription factors play critical roles in plant abiotic stress responses.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	5-8
28753881-12	2018	The MIB1 index (immunostaining for Ki67) was significantly higher in the NAC group.	nac	73-76	MIB E3 ubiquitin protein ligase 1	Homo sapiens	4-8
30314669-1	2018	OBJECTIVE: To investigate the prognostic value of the expressions of programmed cell death ligand 1 (PD-L1) and immune checkpoint markers in residual tumors after neoadjuvant chemotherapy (NAC) for advanced high-grade serous ovarian cancer (HGSOC).	nac	189-192	CD274 molecule	Homo sapiens	69-99
30314669-10	2018	The impact of NAC on PD-L1 expression and stromal TILs varied considerably among individual patients.	nac	14-17	CD274 molecule	Homo sapiens	21-26
30607159-1	2018	Purpose: PIK3CA mutation is considered to be a possible cause for resistance to neoadjuvant chemotherapy (NAC) in human epidermal growth factor receptor 2 (HER2)-positive breast cancer.	nac	106-109	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	9-15
30607159-1	2018	Purpose: PIK3CA mutation is considered to be a possible cause for resistance to neoadjuvant chemotherapy (NAC) in human epidermal growth factor receptor 2 (HER2)-positive breast cancer.	nac	106-109	erb-b2 receptor tyrosine kinase 2	Homo sapiens	120-154
30607159-1	2018	Purpose: PIK3CA mutation is considered to be a possible cause for resistance to neoadjuvant chemotherapy (NAC) in human epidermal growth factor receptor 2 (HER2)-positive breast cancer.	nac	106-109	erb-b2 receptor tyrosine kinase 2	Homo sapiens	156-160
30607159-2	2018	We investigated the association between PIK3CA mutations and the outcome of NAC in HER2-positive breast cancers.	nac	76-79	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	40-46
30607159-2	2018	We investigated the association between PIK3CA mutations and the outcome of NAC in HER2-positive breast cancers.	nac	76-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	83-87
30607159-7	2018	While there was no difference in pCR between the wild-type and mutant PIK3CA groups in pre-NAC specimens (25.0% vs. 31.8%, p=0.199), PIK3CA mutations correlated with lower pCR in post-NAC specimens (0.0% vs. 24.3%, p&lt;0.001).	nac	184-187	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	133-139
30607159-11	2018	These results suggest that PIK3CA mutation is a prognostic marker for NAC in HER2-positive breast cancer, especially in post-NAC specimens.	nac	70-73	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	27-33
30607159-11	2018	These results suggest that PIK3CA mutation is a prognostic marker for NAC in HER2-positive breast cancer, especially in post-NAC specimens.	nac	70-73	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-81
30607159-11	2018	These results suggest that PIK3CA mutation is a prognostic marker for NAC in HER2-positive breast cancer, especially in post-NAC specimens.	nac	125-128	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	27-33
30607159-11	2018	These results suggest that PIK3CA mutation is a prognostic marker for NAC in HER2-positive breast cancer, especially in post-NAC specimens.	nac	125-128	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-81
30193375-1	2018	Importance: A recent publication reported that of 527 patients with clinically node-negative (cN0) cT1/cT2 triple-negative breast cancer (TNBC) or ERBB2-positive disease treated with neoadjuvant chemotherapy (NAC), 100% of those who achieved a breast pathologic complete response (pCR) had pathologic node negativity (pN0).	nac	209-212	cardiotrophin 1	Homo sapiens	99-102
30193375-1	2018	Importance: A recent publication reported that of 527 patients with clinically node-negative (cN0) cT1/cT2 triple-negative breast cancer (TNBC) or ERBB2-positive disease treated with neoadjuvant chemotherapy (NAC), 100% of those who achieved a breast pathologic complete response (pCR) had pathologic node negativity (pN0).	nac	209-212	cancer/testis antigen 2	Homo sapiens	103-106
30193375-1	2018	Importance: A recent publication reported that of 527 patients with clinically node-negative (cN0) cT1/cT2 triple-negative breast cancer (TNBC) or ERBB2-positive disease treated with neoadjuvant chemotherapy (NAC), 100% of those who achieved a breast pathologic complete response (pCR) had pathologic node negativity (pN0).	nac	209-212	erb-b2 receptor tyrosine kinase 2	Homo sapiens	147-152
30193375-9	2018	Main Outcomes and Measures: The pathologic nodal positivity rate after NAC (ypN) specifically in patients with cT1/cT2 cN0 ERBB2-positive disease or TNBC who achieve a breast pCR after NAC.	nac	71-74	cardiotrophin 1	Homo sapiens	111-114
30193375-9	2018	Main Outcomes and Measures: The pathologic nodal positivity rate after NAC (ypN) specifically in patients with cT1/cT2 cN0 ERBB2-positive disease or TNBC who achieve a breast pCR after NAC.	nac	71-74	cancer/testis antigen 2	Homo sapiens	115-118
30193375-9	2018	Main Outcomes and Measures: The pathologic nodal positivity rate after NAC (ypN) specifically in patients with cT1/cT2 cN0 ERBB2-positive disease or TNBC who achieve a breast pCR after NAC.	nac	71-74	erb-b2 receptor tyrosine kinase 2	Homo sapiens	123-128
30466589-1	2018	NAC (NAM, ATAF1/2 and CUC2) transcription factors play critical roles in plant abiotic stress responses.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	10-17
30466589-1	2018	NAC (NAM, ATAF1/2 and CUC2) transcription factors play critical roles in plant abiotic stress responses.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	22-26
30144148-7	2018	After a single FSW, CLZ decreased the number of c-Fos immunoreactive cells in the vLS, DMStr, NAc shell, and NAc core.	nac	94-97	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-53
30406444-1	2018	BACKGROUND: Stromal tumor-infiltrating lymphocytes (sTILs) have been identified as a predictive biomarker for response to neoadjuvant chemotherapy (NAC) and prognosis in human epidermal growth factor receptor 2 (HER2)-positive breast cancers.	nac	148-151	erb-b2 receptor tyrosine kinase 2	Homo sapiens	176-210
30406444-1	2018	BACKGROUND: Stromal tumor-infiltrating lymphocytes (sTILs) have been identified as a predictive biomarker for response to neoadjuvant chemotherapy (NAC) and prognosis in human epidermal growth factor receptor 2 (HER2)-positive breast cancers.	nac	148-151	erb-b2 receptor tyrosine kinase 2	Homo sapiens	212-216
30406444-5	2018	sTIL levels in the pre-NAC core needle biopsy specimens were scored using methods recommended by the International TILs Working Group 2014.	nac	23-26	STIL centriolar assembly protein	Homo sapiens	0-4
30406444-14	2018	CONCLUSIONS: Our study indicates that baseline sTILs scored by methods recommended by the International TILs Working Group in pre-NAC core needle biopsy specimens are significantly correlated with pCR and prognosis in HER2-positive breast cancers.	nac	130-133	erb-b2 receptor tyrosine kinase 2	Homo sapiens	218-222
30444219-2	2018	The aims of this study were to investigate the expression of c-Met in breast cancer tissues and its association with expression of type II topoisomerase (TOPO II), including in patients who received neoadjuvant chemotherapy (NAC), and to investigate chemotherapy resistance in vitro in breast cancer cell lines.	nac	225-228	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	61-66
30444219-5	2018	Forty-five cases of breast cancer treated with NAC were studied to investigate the association between c-Met and TOPO II expression and clinical outcome.	nac	47-50	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	103-108
30156356-6	2018	The patients with tumors highly expressing MFG-E8 had a significantly higher percentage of neoadjuvant chemotherapy (NAC) history (P &lt; .0001) and shorter relapse-free survival (P = 0.012) and overall survival (OS; P = .0047).	nac	117-120	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	43-49
30156356-7	2018	On subgroup analysis, according to NAC history, patients with high MFG-E8 expression had significantly shorter relapse-free survival (P = .027) and OS (P = .0039) only when they had been treated with NAC.	nac	35-38	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	67-73
30156356-7	2018	On subgroup analysis, according to NAC history, patients with high MFG-E8 expression had significantly shorter relapse-free survival (P = .027) and OS (P = .0039) only when they had been treated with NAC.	nac	200-203	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	67-73
30156356-8	2018	Furthermore, tumors with high MFG-E8 expression had a significantly lower ratio of CD8+ T cells/regulatory T cells in tumor-infiltrating lymphocytes (P = .042) only in the patients treated with NAC, and those with a lower ratio had a shorter OS (P = .026).	nac	194-197	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	30-36
30349372-9	2018	Conclusion: Our results revealed that elevated serum miR-4530 levels may sensitize breast cancer to taxane- and anthracycline-based NAC by suppressing RUNX2; therefore, this miRNA has the potential to be a new biomarker for predicting breast cancer chemosensitivity.	nac	132-135	microRNA 4530	Homo sapiens	53-61
29752514-9	2018	NAC was associated with improved overall survival amongst patients with cT3-4aN0 (HR 0.84 95% CI 0.73-0.97; p = 0.02) and cN+ (HR 0.70, 95% CI 0.58-0.86; p = 0.001).	nac	0-3	cancer antigen 1	Homo sapiens	72-75
30347890-1	2018	NAC (NAM, ATAF1/2, and CUC2) transcription factors play important roles in many biological processes, and mainly bind to the NACRS with core sequences "CACG" or "CATGTG" to regulate gene expression.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	5-8
30347890-1	2018	NAC (NAM, ATAF1/2, and CUC2) transcription factors play important roles in many biological processes, and mainly bind to the NACRS with core sequences "CACG" or "CATGTG" to regulate gene expression.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	10-17
30347890-1	2018	NAC (NAM, ATAF1/2, and CUC2) transcription factors play important roles in many biological processes, and mainly bind to the NACRS with core sequences "CACG" or "CATGTG" to regulate gene expression.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	23-27
30370514-12	2018	Pathological response assessment for NAC group showed TRG0 in 6 cases, TRG1 in 8 cases, TRG2 in 17 cases, TRG3 in 34 cases; sensitive (TRG 0 to 2) in 31 cases (47.7%), non-sensitive in 34 cases (52.3%).	nac	37-40	tRNA-Gly (anticodon CCC) 1-1	Homo sapiens	71-75
30370514-12	2018	Pathological response assessment for NAC group showed TRG0 in 6 cases, TRG1 in 8 cases, TRG2 in 17 cases, TRG3 in 34 cases; sensitive (TRG 0 to 2) in 31 cases (47.7%), non-sensitive in 34 cases (52.3%).	nac	37-40	tRNA-Gly (anticodon GCC) 2-6	Homo sapiens	88-92
30370514-12	2018	Pathological response assessment for NAC group showed TRG0 in 6 cases, TRG1 in 8 cases, TRG2 in 17 cases, TRG3 in 34 cases; sensitive (TRG 0 to 2) in 31 cases (47.7%), non-sensitive in 34 cases (52.3%).	nac	37-40	tRNA-Gly (anticodon TCC) 1-1	Homo sapiens	106-110
30185459-8	2018	Selective inhibition of the PrL-NAc pathway at the end of cocaine self-administration blocked the BDNF-induced decrease in cocaine-seeking but had no effect in PBS-infused rats.	nac	32-35	brain-derived neurotrophic factor	Rattus norvegicus	98-102
30349372-9	2018	Conclusion: Our results revealed that elevated serum miR-4530 levels may sensitize breast cancer to taxane- and anthracycline-based NAC by suppressing RUNX2; therefore, this miRNA has the potential to be a new biomarker for predicting breast cancer chemosensitivity.	nac	132-135	RUNX family transcription factor 2	Homo sapiens	151-156
29956095-1	2018	BACKGROUND: The standard of care for breast cancer patients treated with neoadjuvant chemotherapy (NAC) who have a positive sentinel lymph node (+SLN) after NAC is completion axillary lymph node dissection (ALND).	nac	99-102	sarcolipin	Homo sapiens	146-149
29956095-2	2018	This study aimed to develop a nomogram to predict additional nodal disease in patients with +SLN after NAC.	nac	103-106	sarcolipin	Homo sapiens	93-96
29956095-5	2018	RESULTS: The study identified 120 patients with +SLN after NAC and ALND.	nac	59-62	sarcolipin	Homo sapiens	49-52
29978371-12	2018	CONCLUSIONS: The study results also suggest that axillary dissection could be omitted for patients presenting initially with N1 disease and with a negative clipped node as the SLN after NAC due to the low FNR.	nac	186-189	sarcolipin	Homo sapiens	176-179
30275234-0	2018	A Phase I/II Study of NAC with Docetaxel, Cisplatin, and S-1 for Stage III Gastric Cancer.	nac	22-25	proteasome 26S subunit, non-ATPase 1	Homo sapiens	57-89
28422766-14	2018	In conclusion we demonstrate that high numbers of CD68+ monocytic/macrophage cells and PD-L1 expression in IBC shows significant association with NAC response.	nac	146-149	CD68 molecule	Homo sapiens	50-54
28422766-14	2018	In conclusion we demonstrate that high numbers of CD68+ monocytic/macrophage cells and PD-L1 expression in IBC shows significant association with NAC response.	nac	146-149	CD274 molecule	Homo sapiens	87-92
28422766-15	2018	An immune biomarker profile including TILs, PD-LI and CD68 is more sensitive for NAC response prediction than TILs alone.	nac	81-84	CD68 molecule	Homo sapiens	54-58
29971625-10	2018	A different treatment approach to basal-HER2 type is needed even for cases that achieved adequate clinical response after NAC.	nac	122-125	erb-b2 receptor tyrosine kinase 2	Homo sapiens	40-44
29842891-4	2018	There was a significant decrease in the TH-immunoreactivity across NAc in aged animals as compared to the young and middle-aged ones, as revealed by optical densitometry.	nac	67-70	tyrosine hydroxylase	Rattus norvegicus	40-42
30233667-7	2018	The p-IGF-1R levels in the tumor after NAC differed significantly from those prior to NAC (P=0.005); however, this alteration in p-IGF-1R levels was not associated with a shorter OS.	nac	39-42	insulin like growth factor 1 receptor	Homo sapiens	6-12
29842891-7	2018	Our results show that aging impacts the mesolimbic pathway across its rostrocaudal axis, with a decrease of TH-reactivity in NAc and loss of neurons in VTA.	nac	125-128	tyrosine hydroxylase	Rattus norvegicus	108-110
30043438-3	2018	Here, we report a 33-year-old primipara who underwent four courses of NAC therapy, paclitaxel and cisplatin, from 17 to 27 weeks of gestation due to uterine cervical cancer stage IB2.	nac	70-73	mitogen-activated protein kinase 8 interacting protein 2	Homo sapiens	179-182
30412117-11	2018	Women with hormone receptor (HR)-negative tumors were more likely to exhibit pCR than those with HR-positive tumors (P = .007).Decreased BPE of patients with HER2-positive breast cancer may serve as an indicator of NAC effectiveness.	nac	215-218	nuclear receptor subfamily 4 group A member 1	Homo sapiens	11-27
30412117-11	2018	Women with hormone receptor (HR)-negative tumors were more likely to exhibit pCR than those with HR-positive tumors (P = .007).Decreased BPE of patients with HER2-positive breast cancer may serve as an indicator of NAC effectiveness.	nac	215-218	nuclear receptor subfamily 4 group A member 1	Homo sapiens	29-31
30192796-10	2018	Primarily, WRKY, NAC, MYB, AP2/ERF and bZIP transcription factor family genes were highly enriched in all genes sets and were found to regulate 56% of common genes expressed in drought and cold stress.	nac	17-20	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	27-30
30310287-2	2018	The purpose of this study was to evaluate the efficacy and cardiac safety of the concurrent use of trastuzumab and anthracycline-based NAC for human epidermal growth factor receptor 2 (HER2)-positive locally advanced breast cancer.	nac	135-138	erb-b2 receptor tyrosine kinase 2	Homo sapiens	143-183
30310287-2	2018	The purpose of this study was to evaluate the efficacy and cardiac safety of the concurrent use of trastuzumab and anthracycline-based NAC for human epidermal growth factor receptor 2 (HER2)-positive locally advanced breast cancer.	nac	135-138	erb-b2 receptor tyrosine kinase 2	Homo sapiens	185-189
30310287-8	2018	In conclusion, the concurrent use of trastuzumab and anthracycline-based NAC for certain HER2-positive locally advanced breast cancers significantly improves the pCR rates without obvious increases in the cardiotoxicity.	nac	73-76	erb-b2 receptor tyrosine kinase 2	Homo sapiens	89-93
30275685-10	2018	Conclusion: In four NAC regimens for the treatment of Her-2-positive breast cancer, the TCH group exhibited better DFS and 5-year OS.	nac	20-23	erb-b2 receptor tyrosine kinase 2	Homo sapiens	54-59
30241470-1	2018	BACKGROUND: This study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC).	nac	140-143	matrix metallopeptidase 9	Homo sapiens	91-96
30241470-4	2018	Immunohistochemistry was used to detect histological MMP-9 (hMMP-9) expression in patients with residual tumors after NAC.	nac	118-121	matrix metallopeptidase 9	Homo sapiens	53-58
30241470-4	2018	Immunohistochemistry was used to detect histological MMP-9 (hMMP-9) expression in patients with residual tumors after NAC.	nac	118-121	matrix metallopeptidase 9	Homo sapiens	60-66
30241470-5	2018	The value of MMP-9 to predict the response to NAC and patient survival was studied.	nac	46-49	matrix metallopeptidase 9	Homo sapiens	13-18
30241470-10	2018	CONCLUSIONS: Our findings indicate that monitoring serum MMP-9 and detection of histological MMP-9 could help identify TNBC patients who will respond to NAC and will display varying risks of disease relapse.	nac	153-156	matrix metallopeptidase 9	Homo sapiens	57-62
30241470-10	2018	CONCLUSIONS: Our findings indicate that monitoring serum MMP-9 and detection of histological MMP-9 could help identify TNBC patients who will respond to NAC and will display varying risks of disease relapse.	nac	153-156	matrix metallopeptidase 9	Homo sapiens	93-98
30241470-11	2018	MMP-9 may serve as a predictive and prognostic biomarker for tailoring and modifying the NAC strategy for TNBC.	nac	89-92	matrix metallopeptidase 9	Homo sapiens	0-5
29478127-2	2018	The aim of this study was to assess the response to NAC and survival in patients with locally advanced rectal cancer (LARC) according to their RAS/BRAF mutation status.	nac	52-55	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	147-151
29941343-8	2018	Overall, the data show that FGFR3 mutations and elevated expression of ERCC1 in MIBCs are potential predictive biomarkers of the response to NAC.	nac	141-144	fibroblast growth factor receptor 3	Homo sapiens	28-33
29941343-8	2018	Overall, the data show that FGFR3 mutations and elevated expression of ERCC1 in MIBCs are potential predictive biomarkers of the response to NAC.	nac	141-144	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	71-76
29786125-7	2018	The highest proportions and greatest increases in proportions of NAC were seen among triple-negative breast cancers (TNBC; 19.5-33.7%) and HER2+ (HR-/HER2+, 21.5-39.8%; HR+/HER2+, 17.0-33.7%) tumors.	nac	65-68	erb-b2 receptor tyrosine kinase 2	Homo sapiens	139-143
29786125-7	2018	The highest proportions and greatest increases in proportions of NAC were seen among triple-negative breast cancers (TNBC; 19.5-33.7%) and HER2+ (HR-/HER2+, 21.5-39.8%; HR+/HER2+, 17.0-33.7%) tumors.	nac	65-68	erb-b2 receptor tyrosine kinase 2	Homo sapiens	150-154
29786125-7	2018	The highest proportions and greatest increases in proportions of NAC were seen among triple-negative breast cancers (TNBC; 19.5-33.7%) and HER2+ (HR-/HER2+, 21.5-39.8%; HR+/HER2+, 17.0-33.7%) tumors.	nac	65-68	nuclear receptor subfamily 4 group A member 1	Homo sapiens	146-148
29786125-7	2018	The highest proportions and greatest increases in proportions of NAC were seen among triple-negative breast cancers (TNBC; 19.5-33.7%) and HER2+ (HR-/HER2+, 21.5-39.8%; HR+/HER2+, 17.0-33.7%) tumors.	nac	65-68	erb-b2 receptor tyrosine kinase 2	Homo sapiens	150-154
29786125-10	2018	The highest use of NAC is in TNBC and HER2+ disease, with use in these subgroups being twice as frequent as in HR+/HER2- disease.	nac	19-22	erb-b2 receptor tyrosine kinase 2	Homo sapiens	38-42
29786125-10	2018	The highest use of NAC is in TNBC and HER2+ disease, with use in these subgroups being twice as frequent as in HR+/HER2- disease.	nac	19-22	nuclear receptor subfamily 4 group A member 1	Homo sapiens	111-113
29786125-10	2018	The highest use of NAC is in TNBC and HER2+ disease, with use in these subgroups being twice as frequent as in HR+/HER2- disease.	nac	19-22	erb-b2 receptor tyrosine kinase 2	Homo sapiens	115-119
29978369-3	2018	We sought to evaluate the use of SLN surgery and ALND in cN1 patients undergoing NAC.	nac	81-84	5'-nucleotidase, cytosolic IA	Homo sapiens	57-60
29978369-4	2018	METHODS: We identified all patients with biopsy-proven cN1 breast cancer treated with NAC at our institution between January 2009 and December 2017.	nac	86-89	5'-nucleotidase, cytosolic IA	Homo sapiens	55-58
29978369-7	2018	RESULTS: Of 430 cN1 patients treated with NAC, 93 (22%) underwent SLN surgery only, 100 (23%) underwent SLN and ALND, and 237 (55%) underwent ALND only.	nac	42-45	5'-nucleotidase, cytosolic IA	Homo sapiens	16-19
29978369-13	2018	CONCLUSIONS: We observed a significant shift in axillary surgery for cN1 breast cancer patients treated with NAC, with increasing use of SLN surgery to assess nodal treatment response, and decreasing use of ALND.	nac	109-112	5'-nucleotidase, cytosolic IA	Homo sapiens	69-72
30210640-3	2018	After identified all relevant studies that reported the concurrent use of trastuzumab and anthracycline-based NAC for HER2-positive locally advanced breast cancer, five eligible randomized studies were extracted relevant data and assessed for design and quality, and the meta-analysis was conducted to evaluate the risk ratio (RR) of pCR and other interesting outcomes, such as left ventricular ejection fraction (LVEF) decrease more than 10%, responses, recurrence free survival (RFS) and overall survival (OS).	nac	110-113	erb-b2 receptor tyrosine kinase 2	Homo sapiens	118-122
30210640-8	2018	Conclusions: Our meta-analysis of randomized controlled studies showed that pCR rates are significantly higher in the concurrent use of trastuzumab and anthracycline-based NAC compared with the non-concurrent use of trastuzumab and anthracycline-based NAC for certain HER2-positive breast cancer, meanwhile without significant increase of the cardiotoxicity.	nac	172-175	erb-b2 receptor tyrosine kinase 2	Homo sapiens	268-272
29691802-9	2018	The dissociation constants for binding to PS/phosphatidylcholine (PC) liposomes of N-terminally acetylated (NAc) alpha-syn was lower than that of non NAc alpha-syn.	nac	108-111	synuclein alpha	Homo sapiens	113-122
30058183-6	2018	Neural activation (via Fos protein) was quantified in the nucleus accumbens core (NAC) and shell (NAS).	nac	82-85	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-26
30142860-1	2018	BACKGROUND: Many reports suggest that aldehyde dehydrogenase 1 (ALDH1) expression is associated with poorer neoadjuvant chemotherapy (NAC) response in patients with breast cancer; however, the prognostic value of this enzyme in cancer has yet to be confirmed.	nac	134-137	aldehyde dehydrogenase 1 family member A1	Homo sapiens	38-62
30142860-1	2018	BACKGROUND: Many reports suggest that aldehyde dehydrogenase 1 (ALDH1) expression is associated with poorer neoadjuvant chemotherapy (NAC) response in patients with breast cancer; however, the prognostic value of this enzyme in cancer has yet to be confirmed.	nac	134-137	aldehyde dehydrogenase 1 family member A1	Homo sapiens	64-69
30142860-2	2018	Therefore, we conducted a meta-analysis of related studies to investigate the relationship between ALDH1 expression and the NAC response in breast cancer patients.	nac	124-127	aldehyde dehydrogenase 1 family member A1	Homo sapiens	99-104
30142860-5	2018	Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled to estimate the prognostic role of ALDH1 in the NAC response in patients with breast cancer.	nac	114-117	aldehyde dehydrogenase 1 family member A1	Homo sapiens	101-106
30142860-7	2018	RESULTS: Pooled meta-analysis of 10 eligible studies including 1081 patients indicated an association between high ALDH1 expression and poor NAC responses (pooled OR = 0.44, 95% CI: 0.25-0.77, P = .004) with low significant heterogeneity (I = 55.1%, P = .018).	nac	141-144	aldehyde dehydrogenase 1 family member A1	Homo sapiens	115-120
30142860-11	2018	CONCLUSION: Our results suggested that higher ALDH1 expression is associated with poorer NAC responses in patients with breast cancer.	nac	89-92	aldehyde dehydrogenase 1 family member A1	Homo sapiens	46-51
30093965-4	2018	We assessed the expression of APOBEC3B mRNA using pretreatment biopsy specimens of NAC by quantitative real-time PCR (qRT-PCR) and examined the relationship between APOBEC3B mRNA expression and sensitivity to chemotherapy using pathological complete response (pCR) as an indicator.	nac	83-86	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	Homo sapiens	30-38
30093965-5	2018	Further, we assessed the prognostic value of APOBEC3B in the patients receiving NAC.	nac	80-83	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	Homo sapiens	45-53
30093965-14	2018	Conclusions: Our study showed that APOBEC3B mRNA expression correlated with sensitivity to NAC in breast cancer patients.	nac	91-94	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	Homo sapiens	35-43
29728799-12	2018	In DOX-Res group, all 5 patients who pathologically responded to NAC had M2 phenotype (YKL-39-CCL18-).	nac	65-68	chitinase 3 like 2	Homo sapiens	87-93
29654852-10	2018	Additionally, within both groups, the gene expression of the D2R and Oprm1 in the NAc and the VTA were altered suggesting that the reward system was stimulated by both the bingeing behavior and the running wheel activity.	nac	82-85	opioid receptor, mu 1	Rattus norvegicus	69-74
29480449-9	2018	Aggressive adjuvant systemic treatments should be considered for patients with HER2-rich and triple-negative subtype who exhibit tumor shrinkage in NAC but still have high levels of Ki67.	nac	148-151	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-83
29728799-14	2018	CONCLUSIONS: Thus, we showed that in patients with breast cancer who received anthracycline-containing NAC the absence of clinical response is associated with the presence of M2+ macrophage phenotype (YKL-39-CCL18 + or YKL-39 + CCL18-) based on TOP2a overexpression data.	nac	103-106	chitinase 3 like 2	Homo sapiens	201-207
29728799-14	2018	CONCLUSIONS: Thus, we showed that in patients with breast cancer who received anthracycline-containing NAC the absence of clinical response is associated with the presence of M2+ macrophage phenotype (YKL-39-CCL18 + or YKL-39 + CCL18-) based on TOP2a overexpression data.	nac	103-106	C-C motif chemokine ligand 18	Homo sapiens	208-213
29728799-14	2018	CONCLUSIONS: Thus, we showed that in patients with breast cancer who received anthracycline-containing NAC the absence of clinical response is associated with the presence of M2+ macrophage phenotype (YKL-39-CCL18 + or YKL-39 + CCL18-) based on TOP2a overexpression data.	nac	103-106	chitinase 3 like 2	Homo sapiens	219-225
29728799-14	2018	CONCLUSIONS: Thus, we showed that in patients with breast cancer who received anthracycline-containing NAC the absence of clinical response is associated with the presence of M2+ macrophage phenotype (YKL-39-CCL18 + or YKL-39 + CCL18-) based on TOP2a overexpression data.	nac	103-106	C-C motif chemokine ligand 18	Homo sapiens	228-233
29728799-14	2018	CONCLUSIONS: Thus, we showed that in patients with breast cancer who received anthracycline-containing NAC the absence of clinical response is associated with the presence of M2+ macrophage phenotype (YKL-39-CCL18 + or YKL-39 + CCL18-) based on TOP2a overexpression data.	nac	103-106	DNA topoisomerase II alpha	Homo sapiens	245-250
29631006-1	2018	NAC (NAM, ATAF1/2 and CUC) transcription factors play an important role in resisting abiotic stress in plants.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	5-8
29555593-4	2018	These pathways are regulated by kinases (sucrose non-fermenting response like kinase; cyclin dependent protein kinase E 1) and transcription factors from the abscisic acid-related, WRKY and NAC families.	nac	190-193	cyclin	Arabidopsis thaliana	86-92
29631006-1	2018	NAC (NAM, ATAF1/2 and CUC) transcription factors play an important role in resisting abiotic stress in plants.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	10-25
29937503-0	2018	The Direct Involvement of Dark-Induced Tic55 Protein in Chlorophyll Catabolism and Its Indirect Role in the MYB108-NAC Signaling Pathway during Leaf Senescence in Arabidopsis thaliana.	nac	115-118	translocon at the inner envelope membrane of chloroplasts 55-II	Arabidopsis thaliana	39-44
30378301-12	2018	NAC improved the cell viability and inhibited NLRP3 inflammasome activation.	nac	0-3	NLR family, pyrin domain containing 3	Rattus norvegicus	46-51
29657089-2	2018	We investigate how mTOR and phosphorylated mTOR (pmTOR) protein expression correlate with chemoresponsiveness in the tumor and its microenvironment at final pathologic staging after neoadjuvant chemotherapy (NAC).	nac	208-211	mechanistic target of rapamycin kinase	Homo sapiens	43-47
29937503-0	2018	The Direct Involvement of Dark-Induced Tic55 Protein in Chlorophyll Catabolism and Its Indirect Role in the MYB108-NAC Signaling Pathway during Leaf Senescence in Arabidopsis thaliana.	nac	115-118	myb domain protein 108	Arabidopsis thaliana	108-114
29937503-10	2018	In addition, the expression of four NAC genes, including ANAC003, ANAC010, ANAC042, and ANAC075 of IDL treated tic55-II-knockout mutant appeared to be downregulated.	nac	36-39	NAC domain containing protein 3	Arabidopsis thaliana	57-64
29937503-10	2018	In addition, the expression of four NAC genes, including ANAC003, ANAC010, ANAC042, and ANAC075 of IDL treated tic55-II-knockout mutant appeared to be downregulated.	nac	36-39	translocon at the inner envelope membrane of chloroplasts 55-II	Arabidopsis thaliana	111-116
29937503-11	2018	Yeast one hybrid assay revealed that only ANAC003 promoter region can be bound by MYB108, suggesting that a MYB-NAC regulatory network is involved in dark-stressed senescence.	nac	43-46	myb domain protein 108	Arabidopsis thaliana	82-88
29970690-5	2018	Subgroup analysis of the BC patients revealed that both serum PON and ARE levels were lower in patients who needed neoadjuvant chemotherapy (NAC), compared to those who did not (P = 0.024 and 0.02, respectively).	nac	141-144	paraoxonase 1	Homo sapiens	62-65
29970690-9	2018	Both serum PON and ARE levels were lower in patients who needed NAC than in patients who did not need such therapy.	nac	64-67	paraoxonase 1	Homo sapiens	11-14
29536220-5	2018	Deletion analysis of VOZ1 demonstrated that the amino acid residues in its transcriptional regulatory, zinc finger and NAC domains are essential for the DREB2C-AP2 interaction.	nac	119-122	vascular plant one zinc finger protein	Arabidopsis thaliana	21-25
29567092-12	2018	These results indicate that upregulation of NAc GLT-1 transporters alone is not sufficient to prevent the reinstatement of cocaine-seeking and implicate additional mechanisms in regulating glutamate efflux.	nac	44-47	solute carrier family 1 member 2	Rattus norvegicus	48-53
29563612-7	2018	Blockage of ROS with inhibitors, NAC and DPI, markedly decreased the expression of AQP3 and HIF-1alpha in both AGS and GES-1 cells simultaneously.	nac	33-36	aquaporin 3 (Gill blood group)	Homo sapiens	83-87
29844817-5	2018	Low levels of CRT and an overexpression of Ki67 were significantly associated with the stage, histology, and differentiation of the primary surgery without doxorubicin (DOX) neoadjuvant chemotherapy (NAC) patient group and were significantly correlated with a short progression-free survival and the overall survival.	nac	200-203	calreticulin	Homo sapiens	14-17
29844817-7	2018	Low CRT expression and an overexpression of Ki67 were significantly associated with DOX-NAC and the histology (P&lt;0.05) pre-NAC and post-NAC in the DOX-NAC patient group.	nac	88-91	calreticulin	Homo sapiens	4-7
29844817-7	2018	Low CRT expression and an overexpression of Ki67 were significantly associated with DOX-NAC and the histology (P&lt;0.05) pre-NAC and post-NAC in the DOX-NAC patient group.	nac	126-129	calreticulin	Homo sapiens	4-7
29844817-7	2018	Low CRT expression and an overexpression of Ki67 were significantly associated with DOX-NAC and the histology (P&lt;0.05) pre-NAC and post-NAC in the DOX-NAC patient group.	nac	126-129	calreticulin	Homo sapiens	4-7
29844817-7	2018	Low CRT expression and an overexpression of Ki67 were significantly associated with DOX-NAC and the histology (P&lt;0.05) pre-NAC and post-NAC in the DOX-NAC patient group.	nac	126-129	calreticulin	Homo sapiens	4-7
29844817-8	2018	Upon treatment of DOX-NAC, CRT, PERK and p-eIF2alpha protein content were overexpressed in DOX-sensitive endometrial cancer (P&lt;0.05), whereas there was no significant difference in the DOX-resistant group.	nac	22-25	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	32-36
29567092-4	2018	We recently demonstrated that restoration of GLT-1 expression in the NAc is necessary for ceftriaxone to attenuate reinstatement of cocaine-seeking.	nac	69-72	solute carrier family 1 member 2	Rattus norvegicus	45-50
29567092-6	2018	Rats self-administered cocaine for two weeks and received injections of either AAV-GFAP-GLT-1a or AAV-GFAP-eGFP in the NAc following the last day of self-administration.	nac	119-122	glial fibrillary acidic protein	Rattus norvegicus	102-106
29475387-4	2018	RESULTS: In the discovery cohort, comprising 61 patients, the survival ratio after NAC treatment for CCT-alpha-negative patients was significantly increased (p = 0.001) while there was no survival advantage in the CCT-alpha-positive patient group.	nac	83-86	phosphate cytidylyltransferase 1A, choline	Homo sapiens	101-110
29475387-5	2018	Similarly, in the validation cohort with 177 patients, NAC treatment improved survival only in the CCT-alpha-negative group (p = 0.006).	nac	55-58	phosphate cytidylyltransferase 1A, choline	Homo sapiens	99-108
29475387-6	2018	Although there was a tendency for a good NAC response with negative CCT-alpha status, the interaction variable between biomarker and treatment was not significant (p = 0.24).	nac	41-44	phosphate cytidylyltransferase 1A, choline	Homo sapiens	68-77
29937166-2	2018	This study set out to develop a risk scoring system (RSS) for predicting probability of nodal pathological complete response (pCR) in women presenting with cN1 breast cancer who received NAC.	nac	187-190	5'-nucleotidase, cytosolic IA	Homo sapiens	156-159
29937166-3	2018	METHODS: Data of 116 women with cN1 breast cancer who received NAC between January 2009 and December 2013 were abstracted from our prospectively maintained database.	nac	63-66	5'-nucleotidase, cytosolic IA	Homo sapiens	32-35
29536220-5	2018	Deletion analysis of VOZ1 demonstrated that the amino acid residues in its transcriptional regulatory, zinc finger and NAC domains are essential for the DREB2C-AP2 interaction.	nac	119-122	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	153-159
29615063-11	2018	CONCLUSIONS: PD-1 and PD-L1 expressions may be useful as biomarkers to predict treatment responses to NAC in breast cancer.	nac	102-105	programmed cell death 1	Homo sapiens	13-17
29780165-8	2018	Optogenetic inhibition of mPCF neuronal terminals or local infusion of the CRF receptor 1 (CRFR1) antagonist in the NAc restored the effects of neuropathic pain on morphine-induced CPP behavior, but not in normal mice.	nac	116-119	corticotropin releasing hormone receptor 1	Mus musculus	75-89
29780165-8	2018	Optogenetic inhibition of mPCF neuronal terminals or local infusion of the CRF receptor 1 (CRFR1) antagonist in the NAc restored the effects of neuropathic pain on morphine-induced CPP behavior, but not in normal mice.	nac	116-119	corticotropin releasing hormone receptor 1	Mus musculus	91-96
29771430-8	2018	Furthermore, increased expression of SENP3 was found to be dependent on the generation of ROS, as the SENP3 accumulation was inhibited by antioxidant (NAC).	nac	151-154	SUMO specific peptidase 3	Rattus norvegicus	37-42
29771430-8	2018	Furthermore, increased expression of SENP3 was found to be dependent on the generation of ROS, as the SENP3 accumulation was inhibited by antioxidant (NAC).	nac	151-154	SUMO specific peptidase 3	Rattus norvegicus	102-107
29220097-8	2018	CONCLUSIONS: Persistent mass-forming low-cellular or acellular mucin pools can result in discordant clinical, imaging and pathological findings in IMC treated with NAC.	nac	164-167	LOC100508689	Homo sapiens	63-68
29670115-5	2018	During NAC, the proportion of lymphocyte and the percentages of CD3+, CD3+ CD4+, and CD3+ CD8+ lymphocytes were dramatically increased in pCR group.	nac	7-10	CD4 molecule	Homo sapiens	75-78
29670115-5	2018	During NAC, the proportion of lymphocyte and the percentages of CD3+, CD3+ CD4+, and CD3+ CD8+ lymphocytes were dramatically increased in pCR group.	nac	7-10	CD8a molecule	Homo sapiens	90-93
29735678-5	2018	In addition, based on a brain-slice preparation obtained from Drd2-EGFP BAC transgenic mice, we demonstrated direct innervation of D2 receptor-expressing medium spiny neurons (D2-MSNs) in the NAc by prelimbic cortical neurons, which is under the regulation by presynaptic dopamine receptors.	nac	192-195	dopamine receptor D2	Mus musculus	131-142
29780165-9	2018	On a molecular level, in CCI mice, CRFR1 protein expression was increased in the NAc by a histone dimethyltransferase G9a-mediated epigenetic mechanism.	nac	81-84	corticotropin releasing hormone receptor 1	Mus musculus	35-40
29780165-11	2018	Taken together, these findings demonstrate a previously unknown and specific mPFC CRF engagement of NAc neuronal circuits, the sensitization of which facilitates behavioral responses to morphine reward in neuropathic pain states via CRFR1s.	nac	100-103	corticotropin releasing hormone receptor 1	Mus musculus	233-238
29565454-11	2018	In conclusion, the present study revealed SIRT5 as a biomarker for response to anthracycline-taxane-based NAC in patients with TNBC and identified a series of novel biological functions of SIRT5 in breast cancer.	nac	106-109	sirtuin 5	Homo sapiens	42-47
29685462-8	2018	Positive change of ALDH1 after NAC tended to be associated with a poor NAC response (p = 0.078).	nac	31-34	aldehyde dehydrogenase 1 family member A1	Homo sapiens	19-24
29685462-8	2018	Positive change of ALDH1 after NAC tended to be associated with a poor NAC response (p = 0.078).	nac	71-74	aldehyde dehydrogenase 1 family member A1	Homo sapiens	19-24
29685462-9	2018	Patients with more CD8+ T cells before NAC and fewer CD68 (+) macrophages after NAC tended to have better OS, respectively (p = 0.086, p = 0.096).	nac	80-83	CD68 molecule	Homo sapiens	53-57
29615063-11	2018	CONCLUSIONS: PD-1 and PD-L1 expressions may be useful as biomarkers to predict treatment responses to NAC in breast cancer.	nac	102-105	CD274 molecule	Homo sapiens	22-27
29138067-5	2018	RESULTS: In patients with HR-positive (HR+)/HER2-/NG-low tumors, regardless of change in tumor size, the loss of node positivity after NAC significantly improved disease-free survival (DFS).	nac	135-138	nuclear receptor subfamily 4 group A member 1	Homo sapiens	26-28
29138067-5	2018	RESULTS: In patients with HR-positive (HR+)/HER2-/NG-low tumors, regardless of change in tumor size, the loss of node positivity after NAC significantly improved disease-free survival (DFS).	nac	135-138	nuclear receptor subfamily 4 group A member 1	Homo sapiens	39-41
28843513-9	2018	CONCLUSION: We should interpret carefully MRI-CR of NAC to evaluate residual disease for ER++/HER2- BC.	nac	52-55	erb-b2 receptor tyrosine kinase 2	Homo sapiens	94-98
29138067-5	2018	RESULTS: In patients with HR-positive (HR+)/HER2-/NG-low tumors, regardless of change in tumor size, the loss of node positivity after NAC significantly improved disease-free survival (DFS).	nac	135-138	erb-b2 receptor tyrosine kinase 2	Homo sapiens	44-48
29138067-9	2018	CONCLUSION: Our results revealed that changes in tumor stage and nodal status after NAC might be prognostic markers in patients with HR+/HER2-/NG-high tumors or HR-/HER2- tumors, even if there are residual tumors in the breast.	nac	84-87	nuclear receptor subfamily 4 group A member 1	Homo sapiens	133-135
29138067-9	2018	CONCLUSION: Our results revealed that changes in tumor stage and nodal status after NAC might be prognostic markers in patients with HR+/HER2-/NG-high tumors or HR-/HER2- tumors, even if there are residual tumors in the breast.	nac	84-87	erb-b2 receptor tyrosine kinase 2	Homo sapiens	137-141
29872578-8	2018	Elevated levels of YKL-39 expression in tumors after neoadjuvant chemotherapy (NAC) were predictive for increased risk of distant metastasis and for poor response to NAC in patients with nonspecific invasive breast carcinoma.	nac	79-82	chitinase 3 like 2	Homo sapiens	19-25
29872578-8	2018	Elevated levels of YKL-39 expression in tumors after neoadjuvant chemotherapy (NAC) were predictive for increased risk of distant metastasis and for poor response to NAC in patients with nonspecific invasive breast carcinoma.	nac	166-169	chitinase 3 like 2	Homo sapiens	19-25
29514654-2	2018	However, there is little known about conversion frequency of estrogen receptor (ER) and/or progesterone receptor (PR) status for hormone receptor positive-breast cancer patients after NAC and their correlation with prognosis.	nac	184-187	estrogen receptor 1	Homo sapiens	61-78
29514654-2	2018	However, there is little known about conversion frequency of estrogen receptor (ER) and/or progesterone receptor (PR) status for hormone receptor positive-breast cancer patients after NAC and their correlation with prognosis.	nac	184-187	estrogen receptor 1	Homo sapiens	80-82
29514654-2	2018	However, there is little known about conversion frequency of estrogen receptor (ER) and/or progesterone receptor (PR) status for hormone receptor positive-breast cancer patients after NAC and their correlation with prognosis.	nac	184-187	progesterone receptor	Homo sapiens	91-112
29514654-2	2018	However, there is little known about conversion frequency of estrogen receptor (ER) and/or progesterone receptor (PR) status for hormone receptor positive-breast cancer patients after NAC and their correlation with prognosis.	nac	184-187	progesterone receptor	Homo sapiens	114-116
29514654-5	2018	RESULTS: Fifty-five patients (23.8%) had ER and/or PR conversion after NAC.	nac	71-74	progesterone receptor	Homo sapiens	51-53
29556276-11	2018	Similarly, low tumor expression of XPA was significantly associated with higher sensitivity to NAC (P=0.001).	nac	95-98	XPA, DNA damage recognition and repair factor	Homo sapiens	35-38
29556276-6	2018	In the present study, the association between XPA expression in tumor tissue and the efficacy of NAC for locally advanced uterine cervical cancer was investigated.	nac	97-100	XPA, DNA damage recognition and repair factor	Homo sapiens	46-49
29556276-10	2018	It was revealed that the NAC effective group had significantly lower weighted XPA scores than the NAC ineffective group (P=0.001).	nac	25-28	XPA, DNA damage recognition and repair factor	Homo sapiens	78-81
29146239-3	2018	However, the function of the TLR4 signal in the nucleus accumbens shell (NAc-shell), a site implicated in the control of reward, drug-seeking behavior and impulsivity and the contribution of other signal-associated genes, are still poorly understood.	nac	73-76	toll-like receptor 4	Rattus norvegicus	29-33
29146239-4	2018	Here we report that P rats have an innately activated TLR4 signal in NAc-shell neurons that co-express the alpha2 GABAA receptor subunit and CRF prior to alcohol exposure.	nac	69-72	toll-like receptor 4	Rattus norvegicus	54-58
29146239-7	2018	NAc-shell Infusion of a neurotropic, non-replicating herpes simplex virus vector for TLR4-specific small interfering RNA (pHSVsiTLR4) inhibits TLR4 expression and cognitive impulsivity, implicating the CRF-amplified TLR4 signal in impulsivity regulation.	nac	0-3	toll-like receptor 4	Rattus norvegicus	85-89
29146239-7	2018	NAc-shell Infusion of a neurotropic, non-replicating herpes simplex virus vector for TLR4-specific small interfering RNA (pHSVsiTLR4) inhibits TLR4 expression and cognitive impulsivity, implicating the CRF-amplified TLR4 signal in impulsivity regulation.	nac	0-3	toll-like receptor 4	Rattus norvegicus	128-132
29146239-7	2018	NAc-shell Infusion of a neurotropic, non-replicating herpes simplex virus vector for TLR4-specific small interfering RNA (pHSVsiTLR4) inhibits TLR4 expression and cognitive impulsivity, implicating the CRF-amplified TLR4 signal in impulsivity regulation.	nac	0-3	toll-like receptor 4	Rattus norvegicus	128-132
29556276-13	2018	The results of the present study suggest that low XPA expression may be a predictive biomarker of NAC efficacy for patients with locally advanced uterine cervical cancer, which may be helpful for improving their prognosis.	nac	98-101	XPA, DNA damage recognition and repair factor	Homo sapiens	50-53
29204804-4	2018	OBJECTIVES: This study examined whether manipulation of E2 in the mPOA modulates differing behavioral responses to cocaine and whether this is reflected in differing levels of c-Fos in the NAc following cocaine administration.	nac	189-192	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	176-181
29487381-4	2018	Systemic or intra-nucleus accumbens (NAc) administration of the mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) dose-dependently reduced cocaine (and sucrose) self-administration and cocaine-induced reinstatement of drug-seeking behavior.	nac	37-40	glutamate receptor, ionotropic, kainate 1	Mus musculus	64-70
28640975-4	2018	Here, we identify the NAC factor JUNGBRUNNEN1 (JUB1) as a regulator of drought tolerance in tomato (Solanum lycopersicum).	nac	22-25	NAC domain containing protein 42	Arabidopsis thaliana	47-51
29534389-1	2018	Objective: To explore the expression of androgen receptor (AR) in the tissues as well as its association with the clinicopathological factors of primary breast cancer patients treated with neoadjuvant chemotherapy (NAC), and analyze the effect of AR in the prediction of pathologic complete response (PCR) rate.	nac	215-218	androgen receptor	Homo sapiens	40-57
29534389-1	2018	Objective: To explore the expression of androgen receptor (AR) in the tissues as well as its association with the clinicopathological factors of primary breast cancer patients treated with neoadjuvant chemotherapy (NAC), and analyze the effect of AR in the prediction of pathologic complete response (PCR) rate.	nac	215-218	androgen receptor	Homo sapiens	59-61
29033147-2	2018	The aim was to determine if the tumor ADC is useful to differentiate complete pathological response (cPR) from partial pathological response (pPR) during NAC.	nac	154-157	PPR1	Homo sapiens	142-145
29033147-10	2018	CONCLUSIONS: The ADC ratios were useful to differentiate cPR from pPR in breast cancer tumors after NAC.	nac	100-103	PPR1	Homo sapiens	66-69
29181679-7	2018	In cN0 patients, pN0 rates were higher in NAC compared with PS patients in ER-/HER2+ [93.2 vs. 79.0%, odds ratio (OR) 3.64, p &lt; 0.001], ER-/HER2- (89.9 vs. 85.2%, OR 1.55, p &lt; 0.001), and ER+/HER2+ (84.7 vs. 78.3%, OR 1.54, p &lt; 0.001).	nac	42-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-83
29181679-7	2018	In cN0 patients, pN0 rates were higher in NAC compared with PS patients in ER-/HER2+ [93.2 vs. 79.0%, odds ratio (OR) 3.64, p &lt; 0.001], ER-/HER2- (89.9 vs. 85.2%, OR 1.55, p &lt; 0.001), and ER+/HER2+ (84.7 vs. 78.3%, OR 1.54, p &lt; 0.001).	nac	42-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	143-147
29181679-7	2018	In cN0 patients, pN0 rates were higher in NAC compared with PS patients in ER-/HER2+ [93.2 vs. 79.0%, odds ratio (OR) 3.64, p &lt; 0.001], ER-/HER2- (89.9 vs. 85.2%, OR 1.55, p &lt; 0.001), and ER+/HER2+ (84.7 vs. 78.3%, OR 1.54, p &lt; 0.001).	nac	42-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	143-147
29181679-9	2018	In cN1-3 patients, pN0 rates after NAC were 61.3% in ER-/HER2+, 47.7% in ER+/HER2+, 47.3% in ER-/HER2-, and 20.2% in ER+/HER2- and SLN surgery was highest in ER-/HER2+ (28.9%, p &lt; 0.05 versus other subtypes).	nac	35-38	5'-nucleotidase, cytosolic IA	Homo sapiens	3-6
29181679-9	2018	In cN1-3 patients, pN0 rates after NAC were 61.3% in ER-/HER2+, 47.7% in ER+/HER2+, 47.3% in ER-/HER2-, and 20.2% in ER+/HER2- and SLN surgery was highest in ER-/HER2+ (28.9%, p &lt; 0.05 versus other subtypes).	nac	35-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	57-61
29181679-9	2018	In cN1-3 patients, pN0 rates after NAC were 61.3% in ER-/HER2+, 47.7% in ER+/HER2+, 47.3% in ER-/HER2-, and 20.2% in ER+/HER2- and SLN surgery was highest in ER-/HER2+ (28.9%, p &lt; 0.05 versus other subtypes).	nac	35-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-81
29181679-9	2018	In cN1-3 patients, pN0 rates after NAC were 61.3% in ER-/HER2+, 47.7% in ER+/HER2+, 47.3% in ER-/HER2-, and 20.2% in ER+/HER2- and SLN surgery was highest in ER-/HER2+ (28.9%, p &lt; 0.05 versus other subtypes).	nac	35-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-81
29181679-9	2018	In cN1-3 patients, pN0 rates after NAC were 61.3% in ER-/HER2+, 47.7% in ER+/HER2+, 47.3% in ER-/HER2-, and 20.2% in ER+/HER2- and SLN surgery was highest in ER-/HER2+ (28.9%, p &lt; 0.05 versus other subtypes).	nac	35-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-81
29181679-9	2018	In cN1-3 patients, pN0 rates after NAC were 61.3% in ER-/HER2+, 47.7% in ER+/HER2+, 47.3% in ER-/HER2-, and 20.2% in ER+/HER2- and SLN surgery was highest in ER-/HER2+ (28.9%, p &lt; 0.05 versus other subtypes).	nac	35-38	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-81
29181679-11	2018	Among cN+ patients, 20-61% undergoing NAC convert to pN0 depending on tumor type, with lowest nodal response in ER+/HER2- disease.	nac	38-41	erb-b2 receptor tyrosine kinase 2	Homo sapiens	116-120
28993056-11	2018	CONCLUSION: The SUVmax determined after NAC using FDG PET/CT can predict for the pCR and the prognosis of patients with operable HER2+ and TN breast cancer.	nac	40-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	129-133
29487381-10	2018	Together, these results indicate that the therapeutic anti-cocaine effects of mGluR5 antagonists are mediated by elevation of extracellular glutamate in the NAc via an endocannabinoid-CB1 receptor disinhibition mechanism.	nac	157-160	glutamate receptor, ionotropic, kainate 1	Mus musculus	78-84
29487381-10	2018	Together, these results indicate that the therapeutic anti-cocaine effects of mGluR5 antagonists are mediated by elevation of extracellular glutamate in the NAc via an endocannabinoid-CB1 receptor disinhibition mechanism.	nac	157-160	cannabinoid receptor 1 (brain)	Mus musculus	184-187
29314327-5	2018	Using this unit, peptide thioesters of the tandem repeat unit of MUC1 mucin were synthesized by the N-alkylcysteine (NAC) method and used for the one-pot ligation by the thioester method.	nac	117-120	mucin 1, cell surface associated	Homo sapiens	65-69
29440915-1	2018	Objectives: The aim of our study is to evaluate the effect of core needle biopsy (CNB) and subsequent neoadjuvant chemotherapy (NAC) on the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth hormone receptor 2 (HER2) and Ki67 in breast cancer, and the associated influencing factors.	nac	128-131	estrogen receptor 1	Homo sapiens	154-171
29440915-1	2018	Objectives: The aim of our study is to evaluate the effect of core needle biopsy (CNB) and subsequent neoadjuvant chemotherapy (NAC) on the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth hormone receptor 2 (HER2) and Ki67 in breast cancer, and the associated influencing factors.	nac	128-131	estrogen receptor 1	Homo sapiens	173-175
29440915-1	2018	Objectives: The aim of our study is to evaluate the effect of core needle biopsy (CNB) and subsequent neoadjuvant chemotherapy (NAC) on the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth hormone receptor 2 (HER2) and Ki67 in breast cancer, and the associated influencing factors.	nac	128-131	progesterone receptor	Homo sapiens	178-199
29440915-1	2018	Objectives: The aim of our study is to evaluate the effect of core needle biopsy (CNB) and subsequent neoadjuvant chemotherapy (NAC) on the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth hormone receptor 2 (HER2) and Ki67 in breast cancer, and the associated influencing factors.	nac	128-131	progesterone receptor	Homo sapiens	201-203
29440915-1	2018	Objectives: The aim of our study is to evaluate the effect of core needle biopsy (CNB) and subsequent neoadjuvant chemotherapy (NAC) on the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth hormone receptor 2 (HER2) and Ki67 in breast cancer, and the associated influencing factors.	nac	128-131	erb-b2 receptor tyrosine kinase 2	Homo sapiens	249-253
29440915-7	2018	In 143 patients who underwent NAC, a significant decrease was observed in the expression of PR and Ki67 after NAC (P=0.003 and P&lt;0.01, respectively).	nac	30-33	progesterone receptor	Homo sapiens	92-94
29440915-7	2018	In 143 patients who underwent NAC, a significant decrease was observed in the expression of PR and Ki67 after NAC (P=0.003 and P&lt;0.01, respectively).	nac	110-113	progesterone receptor	Homo sapiens	92-94
29440915-10	2018	Decreases in PR and Ki67 expression following NAC could be used as positive prognostic factors.	nac	46-49	progesterone receptor	Homo sapiens	13-15
28808843-10	2018	CONCLUSION: Image-guided marker-clip placement on positive ALNs before NAC and removal with SLNB is technically feasible.	nac	71-74	CAP-Gly domain containing linker protein 1	Homo sapiens	32-36
29102254-11	2018	NAC significantly increased the rate of pT0 from 20.2% to 34.3% (P = 0.007) in cT2 and from 3.8% to 23.9% (P&lt;0.001) in cT3-4.	nac	0-3	cancer/testis antigen 2	Homo sapiens	79-82
29102254-11	2018	NAC significantly increased the rate of pT0 from 20.2% to 34.3% (P = 0.007) in cT2 and from 3.8% to 23.9% (P&lt;0.001) in cT3-4.	nac	0-3	cancer antigen 1	Homo sapiens	122-125
29277802-9	2018	CA125 normalization after the 3rd cycle of NAC was significantly associated with negative DP.	nac	43-46	mucin 16, cell surface associated	Homo sapiens	0-5
29630518-3	2018	OBJECTIVE: In the present study, we analyzed whether pretreatment circulating HOTAIR levels predict the response to NAC and investigated prognostic impact of circulating HOTAIR on disease-free survival (DFS) in breast cancer patients treated with NAC.	nac	116-119	HOX transcript antisense RNA	Homo sapiens	78-84
29630518-7	2018	RESULTS: In 112 serum samples obtained before NAC, high circulating HOTAIR was associated with larger tumor size, more positive lymph nodes as well as more distant metastasis.	nac	46-49	HOX transcript antisense RNA	Homo sapiens	68-74
29290778-8	2018	Conversely, miR-155 was substantially down-regulated in tumour tissues of patients who received preoperative neoadjuvant chemotherapy (NAC) compared with tumour tissues of patients without NAC in cohorts sub-classified to lymph node positive status.	nac	135-138	microRNA 155	Homo sapiens	12-19
29459011-5	2018	In the present study we analyzed the effect of NAC on the distribution of CD68+ and stabilin-1+ TAM in five functionally distinct areas of human breast cancer and their correlations with microvessel density (MVD) and lymphatic microvessel density (LMVD), identified by CD31 and LYVE1, respectively.	nac	47-50	CD68 molecule	Homo sapiens	74-78
29459011-5	2018	In the present study we analyzed the effect of NAC on the distribution of CD68+ and stabilin-1+ TAM in five functionally distinct areas of human breast cancer and their correlations with microvessel density (MVD) and lymphatic microvessel density (LMVD), identified by CD31 and LYVE1, respectively.	nac	47-50	stabilin 1	Homo sapiens	84-94
29459011-8	2018	NAC had enhancing effect on the amount of CD68+ TAM but not stabilin-1+ TAM in soft fibrous stroma.	nac	0-3	CD68 molecule	Homo sapiens	42-46
29459011-11	2018	But after NAC stabilin-1 expressing subpopulation of TAM positively correlated with expression of LYVE-1.	nac	10-13	stabilin 1	Homo sapiens	14-24
29459011-11	2018	But after NAC stabilin-1 expressing subpopulation of TAM positively correlated with expression of LYVE-1.	nac	10-13	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	98-104
31299000-8	2018	TFT was 34.8 days for NAC and 35.6 days for surgery.	nac	22-25	T-box transcription factor T	Homo sapiens	0-3
28194522-10	2018	After exploring several diagnostic criteria, we propose, for future NAC trials in Japan, a diagnosis of "cT3/T4 with cN1/N2/N3," by which inclusion of pathological stage I tumors was reduced to 6.5%, although its sensitivity for pathological stage III tumors decreased to 64.5%.	nac	68-71	5'-nucleotidase, cytosolic IA	Homo sapiens	117-120
29290778-8	2018	Conversely, miR-155 was substantially down-regulated in tumour tissues of patients who received preoperative neoadjuvant chemotherapy (NAC) compared with tumour tissues of patients without NAC in cohorts sub-classified to lymph node positive status.	nac	189-192	microRNA 155	Homo sapiens	12-19
29259849-1	2017	NAC (NAM, no apical meristem; ATAF, Arabidopsis transcription activation factor and CUC, cup-shaped cotyledon) proteins are among the largest transcription factor (TF) families playing fundamental biological processes, including cell expansion and differentiation, and hormone signaling in response to biotic and abiotic stresses.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	5-8
29574326-6	2018	All three SBP genes are upregulated in response to externally applied selenium compounds and the antioxidant NAC selectively downregulates SBP2.	nac	109-112	selenium binding protein	Arabidopsis thaliana	10-13
29574326-6	2018	All three SBP genes are upregulated in response to externally applied selenium compounds and the antioxidant NAC selectively downregulates SBP2.	nac	109-112	selenium-binding protein 2	Arabidopsis thaliana	139-143
29574326-8	2018	We provide evidence that (at least) SBP1 expression is tightly linked to detoxification processes related to oxidative stress, since it is downregulated in the presence of NAC in selenium-treated plants.	nac	172-175	S-ribonuclease binding protein 1	Arabidopsis thaliana	36-40
29138861-3	2018	In the present study, the expression of HMGB1 and calreticulin was evaluated by immunohistochemistry in pre-treatment biopsy specimens and surgically resected specimens, which were obtained from patients with breast cancer (n=52) and esophageal squamous cell carcinoma (ESCC) (n=8) who had been treated with neoadjuvant chemotherapy (NAC).	nac	334-337	high mobility group box 1	Homo sapiens	40-45
29138861-5	2018	As a result, both HMGB1 and calreticulin expression levels were significantly upregulated after NAC in both breast cancer and ESCC tissues.	nac	96-99	high mobility group box 1	Homo sapiens	18-23
29138861-5	2018	As a result, both HMGB1 and calreticulin expression levels were significantly upregulated after NAC in both breast cancer and ESCC tissues.	nac	96-99	calreticulin	Homo sapiens	28-40
30025385-7	2018	CONCLUSION: TN subtype and HER2-positive were the main independent predictors of pCR in women who also had cCR to NAC in breast and breast and axilla, but none was predictor in axilla.	nac	114-117	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-31
29267323-2	2017	Our aim was to evaluate the association of the epidermal growth factor receptor gene (EGFR) polymorphism R497K (rs2227983) with prognostic features and clinical outcomes of breast cancer, including the pathological response to NAC and the recurrence-free survival (RFS).	nac	227-230	epidermal growth factor receptor	Homo sapiens	47-79
29267323-2	2017	Our aim was to evaluate the association of the epidermal growth factor receptor gene (EGFR) polymorphism R497K (rs2227983) with prognostic features and clinical outcomes of breast cancer, including the pathological response to NAC and the recurrence-free survival (RFS).	nac	227-230	epidermal growth factor receptor	Homo sapiens	86-90
28942098-8	2017	Age &lt;50 years, breast MRI, large tumour size, advanced nodal disease, negative hormone receptor status and hospital participation in neoadjuvant clinical studies were significant independent predictors of NAC use (all P &lt; 0.001).	nac	208-211	nuclear receptor subfamily 4 group A member 1	Homo sapiens	82-98
28762114-8	2017	The ALND rates in the upfront mastectomy group were higher than in the NAC group for HER2+ or TN tumors.	nac	71-74	erb-b2 receptor tyrosine kinase 2	Homo sapiens	85-89
28881893-3	2017	However, the role of CRP/Alb ratio for those with neoadjuvant chemotherapy (NAC) and the changes of CRP/Alb ratio around NAC have never been discussed.	nac	121-124	C-reactive protein	Homo sapiens	100-103
28881893-3	2017	However, the role of CRP/Alb ratio for those with neoadjuvant chemotherapy (NAC) and the changes of CRP/Alb ratio around NAC have never been discussed.	nac	121-124	albumin	Homo sapiens	104-107
28881893-4	2017	The aim of this study is to evaluate the significance of CRP/Alb ratio around NAC for patients with cStage II/III esophageal squamous cell cancer (ESCC).	nac	78-81	C-reactive protein	Homo sapiens	57-60
28881893-4	2017	The aim of this study is to evaluate the significance of CRP/Alb ratio around NAC for patients with cStage II/III esophageal squamous cell cancer (ESCC).	nac	78-81	albumin	Homo sapiens	61-64
28881893-6	2017	We retrospectively investigated the relation between pre-NAC and post-NAC CRP/Alb ratio and short and long outcomes.	nac	57-60	albumin	Homo sapiens	78-81
28881893-6	2017	We retrospectively investigated the relation between pre-NAC and post-NAC CRP/Alb ratio and short and long outcomes.	nac	70-73	C-reactive protein	Homo sapiens	74-77
28881893-7	2017	The optimal cutoff level for pre-NAC and post-NAC CRP/Alb ratio was 0.030 and 0.048, respectively.	nac	46-49	C-reactive protein	Homo sapiens	50-53
28881893-7	2017	The optimal cutoff level for pre-NAC and post-NAC CRP/Alb ratio was 0.030 and 0.048, respectively.	nac	46-49	albumin	Homo sapiens	54-57
28881893-9	2017	Post-NAC CRP/Alb ratio &lt; 0.048 had a significantly higher overall survival rate than CRP/Alb ratio &gt;=0.048 (P&lt; 0.001).	nac	5-8	C-reactive protein	Homo sapiens	9-12
28881893-9	2017	Post-NAC CRP/Alb ratio &lt; 0.048 had a significantly higher overall survival rate than CRP/Alb ratio &gt;=0.048 (P&lt; 0.001).	nac	5-8	albumin	Homo sapiens	13-16
28881893-10	2017	Univariate analysis showed that cT, cN, pre-NAC CRP/Alb ratio &lt; 0.030 and post-NAC CRP/Alb ratio &lt; 0.048 was prognostic factors (P= 0.003, P= 0.022, P= 0.033, and P&lt; 0.001, respectively).	nac	44-47	C-reactive protein	Homo sapiens	48-51
28881893-10	2017	Univariate analysis showed that cT, cN, pre-NAC CRP/Alb ratio &lt; 0.030 and post-NAC CRP/Alb ratio &lt; 0.048 was prognostic factors (P= 0.003, P= 0.022, P= 0.033, and P&lt; 0.001, respectively).	nac	82-85	C-reactive protein	Homo sapiens	86-89
28881893-10	2017	Univariate analysis showed that cT, cN, pre-NAC CRP/Alb ratio &lt; 0.030 and post-NAC CRP/Alb ratio &lt; 0.048 was prognostic factors (P= 0.003, P= 0.022, P= 0.033, and P&lt; 0.001, respectively).	nac	82-85	albumin	Homo sapiens	90-93
28881893-11	2017	Multivariate analysis showed that cT and post-NAC CRP/Alb ratio &lt; 0.048 was independent prognostic factors (P= 0.030 and P&lt; 0.001, respectively).	nac	46-49	C-reactive protein	Homo sapiens	50-53
28881893-11	2017	Multivariate analysis showed that cT and post-NAC CRP/Alb ratio &lt; 0.048 was independent prognostic factors (P= 0.030 and P&lt; 0.001, respectively).	nac	46-49	albumin	Homo sapiens	54-57
28881893-12	2017	Post-NAC CRP/Alb ratio is an independent prognostic factor in patients with cStage II/III ESCC.	nac	5-8	C-reactive protein	Homo sapiens	9-12
28881893-12	2017	Post-NAC CRP/Alb ratio is an independent prognostic factor in patients with cStage II/III ESCC.	nac	5-8	albumin	Homo sapiens	13-16
28767137-1	2017	BACKGROUND: We aimed to assess change in HER2 status after neoadjuvant chemotherapy (NAC) in patients with primary breast cancer and the prognostic impact of such changes.	nac	85-88	erb-b2 receptor tyrosine kinase 2	Homo sapiens	41-45
28767137-7	2017	ER and PR-positivity before NAC were associated with loss of HER2-positivity, whereas receiving trastuzumab was not.	nac	28-31	erb-b2 receptor tyrosine kinase 2	Homo sapiens	61-65
28828583-1	2017	BACKGROUND: Improved staging systems that better predict survival for breast cancer patients who receive neoadjuvant chemotherapy (NAC) by accounting for clinical pathological stage plus estrogen receptor (ER) and grade (CPS+EG) and ERBB2 status (Neo-Bioscore) have been proposed.	nac	131-134	estrogen receptor 1	Homo sapiens	187-204
28828583-1	2017	BACKGROUND: Improved staging systems that better predict survival for breast cancer patients who receive neoadjuvant chemotherapy (NAC) by accounting for clinical pathological stage plus estrogen receptor (ER) and grade (CPS+EG) and ERBB2 status (Neo-Bioscore) have been proposed.	nac	131-134	estrogen receptor 1	Homo sapiens	206-208
28828583-1	2017	BACKGROUND: Improved staging systems that better predict survival for breast cancer patients who receive neoadjuvant chemotherapy (NAC) by accounting for clinical pathological stage plus estrogen receptor (ER) and grade (CPS+EG) and ERBB2 status (Neo-Bioscore) have been proposed.	nac	131-134	erb-b2 receptor tyrosine kinase 2	Homo sapiens	233-238
28828583-11	2017	CONCLUSIONS: In a heterogenous national cohort of breast cancer patients treated with NAC and surgery, the incorporation of chemotherapy response, tumor grade, ER status, and ERBB2 status into the staging system substantially improved on the AJCC TNM staging system in discrimination of OS.	nac	86-89	erb-b2 receptor tyrosine kinase 2	Homo sapiens	175-180
28881893-3	2017	However, the role of CRP/Alb ratio for those with neoadjuvant chemotherapy (NAC) and the changes of CRP/Alb ratio around NAC have never been discussed.	nac	76-79	C-reactive protein	Homo sapiens	21-24
28762114-9	2017	In the multivariable analysis, receipt of NAC compared with upfront BCS remained significantly associated with higher odds of ALND in the ER/PR+ HER2- subtype (hazard ratio [HR], 3.35; p &lt; 0.001), whereas NAC versus upfront mastectomy remained significantly associated with lower odds of ALND in the HER2+ and TN subtypes (HR for HER2+, 0.19, p &lt; 0.001; HR for TN, 0.25, p = 0.007).	nac	42-45	estrogen receptor 1	Homo sapiens	138-140
28762114-9	2017	In the multivariable analysis, receipt of NAC compared with upfront BCS remained significantly associated with higher odds of ALND in the ER/PR+ HER2- subtype (hazard ratio [HR], 3.35; p &lt; 0.001), whereas NAC versus upfront mastectomy remained significantly associated with lower odds of ALND in the HER2+ and TN subtypes (HR for HER2+, 0.19, p &lt; 0.001; HR for TN, 0.25, p = 0.007).	nac	42-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	145-149
28762114-9	2017	In the multivariable analysis, receipt of NAC compared with upfront BCS remained significantly associated with higher odds of ALND in the ER/PR+ HER2- subtype (hazard ratio [HR], 3.35; p &lt; 0.001), whereas NAC versus upfront mastectomy remained significantly associated with lower odds of ALND in the HER2+ and TN subtypes (HR for HER2+, 0.19, p &lt; 0.001; HR for TN, 0.25, p = 0.007).	nac	42-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	303-307
28762114-9	2017	In the multivariable analysis, receipt of NAC compared with upfront BCS remained significantly associated with higher odds of ALND in the ER/PR+ HER2- subtype (hazard ratio [HR], 3.35; p &lt; 0.001), whereas NAC versus upfront mastectomy remained significantly associated with lower odds of ALND in the HER2+ and TN subtypes (HR for HER2+, 0.19, p &lt; 0.001; HR for TN, 0.25, p = 0.007).	nac	42-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	303-307
28390647-5	2017	RESULTS: c-Fos expression in and firing of contralateral VTA-NAc dopaminergic neurons were elevated in CCI mice, and optogenetic inhibition of these neurons reversed CCI-induced thermal hyperalgesia.	nac	61-64	FBJ osteosarcoma oncogene	Mus musculus	9-14
28944897-4	2017	Therefore, the present study aimed to investigate the expression of endoglin, a marker of angiogenesis, and its association with pathologic responses to NAC.	nac	153-156	endoglin	Homo sapiens	68-76
28944897-10	2017	Increased expression of mTOR following NAC was additionally correlated with improved response to NAC.	nac	39-42	mechanistic target of rapamycin kinase	Homo sapiens	24-28
28944897-10	2017	Increased expression of mTOR following NAC was additionally correlated with improved response to NAC.	nac	97-100	mechanistic target of rapamycin kinase	Homo sapiens	24-28
28944897-11	2017	The results of the present study demonstrated that the expression of endoglin in breast tumor samples prior to NAC may be a predictor of treatment response.	nac	111-114	endoglin	Homo sapiens	69-77
28944897-12	2017	Long-term follow-up of clinical outcome is required to explain the elevation of mTOR expression levels following NAC treatment in responsive tumors.	nac	113-116	mechanistic target of rapamycin kinase	Homo sapiens	80-84
29052527-3	2017	CASE PRESENTATION: We describe a female patient with left breast cancer (T2N2M0) who underwent negative conversion of HER-2 in the primary tumor instead of the synchronous nodal lesions after NAC.	nac	192-195	erb-b2 receptor tyrosine kinase 2	Homo sapiens	118-123
29052527-10	2017	CONCLUSIONS: We propose further assessment of HER2 gene in the synchronous nodal metastases, especially when negative genic switch of HER-2 occurs in the primary tumor after NAC in order to tailor the systemic regimens for breast cancer patients.	nac	174-177	erb-b2 receptor tyrosine kinase 2	Homo sapiens	46-50
28390647-7	2017	This increase was reversed by pharmacological inhibition of VTA dopaminergic neuron activity, which induced an antinociceptive effect that was neutralized by injecting exogenous BDNF into the NAc.	nac	192-195	brain derived neurotrophic factor	Mus musculus	178-182
28390647-8	2017	Moreover, inhibition of BDNF synthesis in the VTA with anisomycin or selective knockdown of BDNF in the VTA-NAc pathway was antinociceptive in CCI mice.	nac	108-111	brain derived neurotrophic factor	Mus musculus	92-96
28811669-7	2017	PVT neurons receive GLP-1 innervation from nucleus tractus solitarius preproglucagon neurons that were activated by food intake; these GLP-1 fibers formed close appositions to putative GLP-1R-expressing PVT cells that project to the NAc.	nac	233-236	glucagon like peptide 1 receptor	Homo sapiens	135-140
28811669-8	2017	Electrophysiological recordings of PVT-to-NAc neurons revealed that GLP-1R activation reduced their excitability, mediated in part via suppression of excitatory synaptic drive.	nac	42-45	glucagon like peptide 1 receptor	Homo sapiens	68-74
29070044-1	2017	BACKGROUND: The response to neoadjuvant chemotherapy (NAC) varies by estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) statuses, with responses being lower in ER-positive, HER2-negative tumors as compared with ER-negative, HER2-positive or triple-negative tumors.	nac	54-57	estrogen receptor 1	Homo sapiens	69-86
29070044-1	2017	BACKGROUND: The response to neoadjuvant chemotherapy (NAC) varies by estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) statuses, with responses being lower in ER-positive, HER2-negative tumors as compared with ER-negative, HER2-positive or triple-negative tumors.	nac	54-57	estrogen receptor 1	Homo sapiens	88-90
29070044-1	2017	BACKGROUND: The response to neoadjuvant chemotherapy (NAC) varies by estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) statuses, with responses being lower in ER-positive, HER2-negative tumors as compared with ER-negative, HER2-positive or triple-negative tumors.	nac	54-57	erb-b2 receptor tyrosine kinase 2	Homo sapiens	102-136
29070044-1	2017	BACKGROUND: The response to neoadjuvant chemotherapy (NAC) varies by estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) statuses, with responses being lower in ER-positive, HER2-negative tumors as compared with ER-negative, HER2-positive or triple-negative tumors.	nac	54-57	erb-b2 receptor tyrosine kinase 2	Homo sapiens	138-142
29070044-1	2017	BACKGROUND: The response to neoadjuvant chemotherapy (NAC) varies by estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) statuses, with responses being lower in ER-positive, HER2-negative tumors as compared with ER-negative, HER2-positive or triple-negative tumors.	nac	54-57	estrogen receptor 1	Homo sapiens	139-141
29070044-1	2017	BACKGROUND: The response to neoadjuvant chemotherapy (NAC) varies by estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) statuses, with responses being lower in ER-positive, HER2-negative tumors as compared with ER-negative, HER2-positive or triple-negative tumors.	nac	54-57	erb-b2 receptor tyrosine kinase 2	Homo sapiens	197-201
29070044-1	2017	BACKGROUND: The response to neoadjuvant chemotherapy (NAC) varies by estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) statuses, with responses being lower in ER-positive, HER2-negative tumors as compared with ER-negative, HER2-positive or triple-negative tumors.	nac	54-57	estrogen receptor 1	Homo sapiens	139-141
29070044-1	2017	BACKGROUND: The response to neoadjuvant chemotherapy (NAC) varies by estrogen receptor (ER) and human epidermal growth factor receptor 2 (HER2) statuses, with responses being lower in ER-positive, HER2-negative tumors as compared with ER-negative, HER2-positive or triple-negative tumors.	nac	54-57	erb-b2 receptor tyrosine kinase 2	Homo sapiens	197-201
28978923-6	2017	In this immunohistochemical study we evaluated the predictive roles of three immunological markers, CD68, MAC387, and CLEVER-1, in response to NAC and outcome of BC.	nac	143-146	CD68 molecule	Homo sapiens	100-104
29026117-4	2017	We overexpressed TMEM168 in the nucleus accumbens of mice by using an adeno-associated virus vector (NAc-TMEM mice).	nac	101-104	transmembrane protein 168	Mus musculus	17-24
29026117-9	2017	Similarly, osteopontin enhancement was also observed in the nucleus accumbens of NAc-TMEM mice, in in vivo studies.	nac	81-84	secreted phosphoprotein 1	Mus musculus	11-22
29190949-6	2017	Univariate and multivariate analyses demonstrated that CD8+ TIL density was an independent and significant predictive factor for the response to NAC, progression-free survival (PFS) and overall survival (OS), whereas PD-L1 or HLA class I expression did not significantly correlate.	nac	145-148	CD8a molecule	Homo sapiens	55-58
29190949-8	2017	These results suggest that PD-L1 expression levels combined with CD8+ TIL density may serve as a predictive biomarker for patients with stage III or IV HPSCC receiving NAC.	nac	168-171	CD274 molecule	Homo sapiens	27-32
29190949-8	2017	These results suggest that PD-L1 expression levels combined with CD8+ TIL density may serve as a predictive biomarker for patients with stage III or IV HPSCC receiving NAC.	nac	168-171	CD8a molecule	Homo sapiens	65-68
28978923-6	2017	In this immunohistochemical study we evaluated the predictive roles of three immunological markers, CD68, MAC387, and CLEVER-1, in response to NAC and outcome of BC.	nac	143-146	S100 calcium binding protein A9	Homo sapiens	106-112
28978923-6	2017	In this immunohistochemical study we evaluated the predictive roles of three immunological markers, CD68, MAC387, and CLEVER-1, in response to NAC and outcome of BC.	nac	143-146	stabilin 1	Homo sapiens	118-126
28978923-9	2017	In contrast, MAC387+ cells and CLEVER-1+ macrophages associated with poor NAC response, while CLEVER-1+ vessels associated with more favourable response to NAC.	nac	74-77	S100 calcium binding protein A9	Homo sapiens	13-19
28978923-9	2017	In contrast, MAC387+ cells and CLEVER-1+ macrophages associated with poor NAC response, while CLEVER-1+ vessels associated with more favourable response to NAC.	nac	74-77	stabilin 1	Homo sapiens	31-39
28978923-9	2017	In contrast, MAC387+ cells and CLEVER-1+ macrophages associated with poor NAC response, while CLEVER-1+ vessels associated with more favourable response to NAC.	nac	156-159	stabilin 1	Homo sapiens	94-102
28978923-10	2017	Higher counts of CLEVER-1+ macrophages associated with poorer overall survival and CD68+ macrophages seem to have an independent prognostic value in BC patients treated with NAC.	nac	174-177	stabilin 1	Homo sapiens	17-25
28978923-10	2017	Higher counts of CLEVER-1+ macrophages associated with poorer overall survival and CD68+ macrophages seem to have an independent prognostic value in BC patients treated with NAC.	nac	174-177	CD68 molecule	Homo sapiens	83-87
28982751-7	2017	As an example of response, NAC dramatically reduces mortality in patients with small cell BCA, and is thus the standard of care, even in stage cT1 disease.	nac	27-30	cardiotrophin 1	Homo sapiens	143-146
28531348-6	2017	Notably, the strength of several NAC-EDLL fusions exceeded that of the strong yeast TDH3 promoter by 6- to 10-fold.	nac	33-36	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3	Saccharomyces cerevisiae S288C	84-88
28884328-6	2017	In our study, we identified a G. soja NAC gene, GsNAC019, which is a homolog of the Arabidopsis AtNAC019 gene.	nac	38-41	NAC domain containing protein 19	Arabidopsis thaliana	96-104
29151924-2	2017	The study aims at investigating the most reliable CA125-related factors in terms of predicting survival outcomes in advanced-stage epithelial ovarian carcinoma (EOC) patients received neoadjuvant chemotherapy (NAC).	nac	210-213	mucin 16, cell surface associated	Homo sapiens	50-55
29151924-13	2017	Our study suggests that the CA125 nadir value is the most reliable prognostic factor to predict PFS and OS in advanced EOC patients treated with NAC.	nac	145-148	mucin 16, cell surface associated	Homo sapiens	28-33
28937963-12	2017	Increased TILs in TN and HR-, HER2+ subtypes predict benefit from addition of carboplatin to NAC.	nac	93-96	erb-b2 receptor tyrosine kinase 2	Homo sapiens	30-34
28911063-12	2017	In the population with residual disease, TIL levels &gt;25% at the end of NAC were significantly associated with an adverse outcome (TILs &gt;25%, HR = 7.98, P = 0.009) after multivariate analyses including BMI, post-NAC mitotic index and tumor grade.	nac	74-77	toll like receptor 1	Homo sapiens	41-44
28910957-10	2017	Among them, the effect of NAC in patients with two or more genes copy number variations of c-Myc, CCND1, p53, p16 were poorer than that in patients with one or not gene copy number variations (P=0.000).	nac	26-29	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	91-96
28910957-10	2017	Among them, the effect of NAC in patients with two or more genes copy number variations of c-Myc, CCND1, p53, p16 were poorer than that in patients with one or not gene copy number variations (P=0.000).	nac	26-29	cyclin D1	Homo sapiens	98-103
28910957-10	2017	Among them, the effect of NAC in patients with two or more genes copy number variations of c-Myc, CCND1, p53, p16 were poorer than that in patients with one or not gene copy number variations (P=0.000).	nac	26-29	tumor protein p53	Homo sapiens	105-108
28910957-10	2017	Among them, the effect of NAC in patients with two or more genes copy number variations of c-Myc, CCND1, p53, p16 were poorer than that in patients with one or not gene copy number variations (P=0.000).	nac	26-29	cyclin dependent kinase inhibitor 2A	Homo sapiens	110-113
28910957-12	2017	Conclusion: These results indicated that the copy number variations of c-Myc, CCND1, p53, and p16 in patients were significant correlation with poor effect of NAC.	nac	159-162	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	71-76
28910957-12	2017	Conclusion: These results indicated that the copy number variations of c-Myc, CCND1, p53, and p16 in patients were significant correlation with poor effect of NAC.	nac	159-162	cyclin D1	Homo sapiens	78-83
28877262-7	2017	RER1 effects were specific to alphaSyn and had little to no effect on either betaSyn or the Delta71-82 alphaSyn mutant, which both lack the NAC domain sequence critical for synuclein fibrillization.	nac	140-143	retention in endoplasmic reticulum sorting receptor 1	Homo sapiens	0-4
28910957-12	2017	Conclusion: These results indicated that the copy number variations of c-Myc, CCND1, p53, and p16 in patients were significant correlation with poor effect of NAC.	nac	159-162	tumor protein p53	Homo sapiens	85-88
28910957-12	2017	Conclusion: These results indicated that the copy number variations of c-Myc, CCND1, p53, and p16 in patients were significant correlation with poor effect of NAC.	nac	159-162	cyclin dependent kinase inhibitor 2A	Homo sapiens	94-97
28484921-3	2017	METHODS: Using the National Cancer Database (NCDB) from January 2010 to December 2012, we identified cT1-T4c, N0-N3 breast cancer patients treated with NAC.	nac	152-155	cardiotrophin 1	Homo sapiens	101-104
28560596-1	2017	BACKGROUND: The benefit of neoadjuvant chemotherapy (NAC) in patients with estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancers and in invasive lobular carcinoma (ILC) is uncertain due to the low rates of pathologic complete response (pCR).	nac	53-56	erb-b2 receptor tyrosine kinase 2	Homo sapiens	114-148
28560596-1	2017	BACKGROUND: The benefit of neoadjuvant chemotherapy (NAC) in patients with estrogen receptor-positive (ER+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancers and in invasive lobular carcinoma (ILC) is uncertain due to the low rates of pathologic complete response (pCR).	nac	53-56	erb-b2 receptor tyrosine kinase 2	Homo sapiens	159-163
28560596-12	2017	CONCLUSIONS: ER+/HER2- patients most likely to benefit from NAC are those with PR- and HP tumors.	nac	60-63	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-21
28560596-12	2017	CONCLUSIONS: ER+/HER2- patients most likely to benefit from NAC are those with PR- and HP tumors.	nac	60-63	progesterone receptor	Homo sapiens	79-81
28911063-12	2017	In the population with residual disease, TIL levels &gt;25% at the end of NAC were significantly associated with an adverse outcome (TILs &gt;25%, HR = 7.98, P = 0.009) after multivariate analyses including BMI, post-NAC mitotic index and tumor grade.	nac	217-220	toll like receptor 1	Homo sapiens	41-44
28756977-3	2017	We postulated that a subpopulation of TNBC cells expressing IMP3, an oncofetal protein, could be resistant to NAC, contributing to the poor prognosis.	nac	110-113	IMP U3 small nucleolar ribonucleoprotein 3	Homo sapiens	60-64
28756977-4	2017	We investigated immunohistochemical expression of IMP3 in 42 TNBC patients who underwent NAC in association with clinical outcomes.	nac	89-92	IMP U3 small nucleolar ribonucleoprotein 3	Homo sapiens	50-54
28646331-12	2017	CONCLUSIONS: The early changes in the textural features of 18F-FDG PET images after two cycles of NAC are predictive of pCR in both HER2-negative and HER2-positive patients; this evidence warrants confirmation by further research.	nac	98-101	erb-b2 receptor tyrosine kinase 2	Homo sapiens	150-154
28756977-8	2017	In a Cox proportional hazard model, IMP3 expression was independently associated with poor NAC response and clinical outcomes (p=0.03 and 0.046, respectively).	nac	91-94	IMP U3 small nucleolar ribonucleoprotein 3	Homo sapiens	36-40
28756977-10	2017	These findings suggest that IMP3+tumor cells contributed to the poor clinical outcomes by exerting a chemoresistance to NAC, and that IMP3 expression has prognostic value as a biomarker for chemosensitivity and overall survival in TNBC.	nac	120-123	IMP U3 small nucleolar ribonucleoprotein 3	Homo sapiens	28-32
28646331-12	2017	CONCLUSIONS: The early changes in the textural features of 18F-FDG PET images after two cycles of NAC are predictive of pCR in both HER2-negative and HER2-positive patients; this evidence warrants confirmation by further research.	nac	98-101	erb-b2 receptor tyrosine kinase 2	Homo sapiens	132-136
28724622-4	2017	Here, we show that although the MYB26 transcript shows expression in multiple floral organs, the MYB26 protein is localized specifically to the anther endothecium nuclei and that it directly regulates two NAC domain genes, NST1 and NST2, which are critical for the induction of secondary thickening biosynthesis genes.	nac	205-208	N-deacetylase and N-sulfotransferase 2	Homo sapiens	232-236
28247194-2	2017	The aim of this study was to assess the associations of NLR and PLR with estrogen receptor (ER) and progesterone receptor (PR) expression in locally advanced breast cancer patients and their changes after neoadjuvant chemotherapy (NAC).	nac	231-234	estrogen receptor 1	Homo sapiens	73-90
28247194-2	2017	The aim of this study was to assess the associations of NLR and PLR with estrogen receptor (ER) and progesterone receptor (PR) expression in locally advanced breast cancer patients and their changes after neoadjuvant chemotherapy (NAC).	nac	231-234	progesterone receptor	Homo sapiens	100-121
28247194-11	2017	Changes in ER and PR expression status or level occured following NAC.	nac	66-69	estrogen receptor 1	Homo sapiens	11-13
28247194-11	2017	Changes in ER and PR expression status or level occured following NAC.	nac	66-69	progesterone receptor	Homo sapiens	18-20
28816938-6	2017	Treating liver cancer cells with antioxidant N-acetyl cystein (NAC) partly blocked AGEs-induced ChREBP expression and cell proliferation.Our results suggest that the AGEs-ROS-ChREBP pathway plays a critical role in promoting ChREBP expression and liver cancer cell proliferation.	nac	63-66	MLX interacting protein like	Homo sapiens	96-102
28816938-6	2017	Treating liver cancer cells with antioxidant N-acetyl cystein (NAC) partly blocked AGEs-induced ChREBP expression and cell proliferation.Our results suggest that the AGEs-ROS-ChREBP pathway plays a critical role in promoting ChREBP expression and liver cancer cell proliferation.	nac	63-66	MLX interacting protein like	Homo sapiens	175-181
28816938-6	2017	Treating liver cancer cells with antioxidant N-acetyl cystein (NAC) partly blocked AGEs-induced ChREBP expression and cell proliferation.Our results suggest that the AGEs-ROS-ChREBP pathway plays a critical role in promoting ChREBP expression and liver cancer cell proliferation.	nac	63-66	MLX interacting protein like	Homo sapiens	175-181
28493311-4	2017	We report that the gene underlying ETHQV6.3 is MELO3C016540 (CmNAC-NOR), encoding a NAC (NAM, ATAF1,2, CUC2) transcription factor that is closely related to the tomato NOR (non-ripening) gene.	nac	63-66	NO APICAL MERISTEM	Solanum lycopersicum	89-92
29951604-10	2017	Conclusion: Her2 positivity was associated with increased rates of axillary pCR and reduced nodal burden following NAC.	nac	115-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	12-16
28487223-9	2017	Also, we found selective Nr1 upregulation in NAc shell and the PFC of female offspring.	nac	45-48	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	25-28
28693257-10	2017	The present study investigated the association between UCP2 expression and NAC effectiveness.	nac	75-78	uncoupling protein 2	Homo sapiens	55-59
28693257-16	2017	UCP2 weighted score was higher in the NAC ineffective group than in the NAC effective group (P=0.038).	nac	38-41	uncoupling protein 2	Homo sapiens	0-4
28693257-16	2017	UCP2 weighted score was higher in the NAC ineffective group than in the NAC effective group (P=0.038).	nac	72-75	uncoupling protein 2	Homo sapiens	0-4
28693257-17	2017	Additionally, the low UCP2 expression group was more sensitive to NAC than the high UCP2 expression group (P=0.041).	nac	66-69	uncoupling protein 2	Homo sapiens	22-26
28693257-19	2017	UCP2 expression may become a predictive marker of whether NAC is effective for patients with locally advanced uterine cervical cancer, which could improve patient prognosis.	nac	58-61	uncoupling protein 2	Homo sapiens	0-4
28495973-4	2017	Intra-NAc xCT knockdown prevented ceftriaxone from attenuating reinstatement and from upregulating GLT-1 and resulted in increased surface expression of AMPA receptor subunits GluA1 and GluA2.	nac	6-9	solute carrier family 1 member 2	Rattus norvegicus	99-104
28495973-4	2017	Intra-NAc xCT knockdown prevented ceftriaxone from attenuating reinstatement and from upregulating GLT-1 and resulted in increased surface expression of AMPA receptor subunits GluA1 and GluA2.	nac	6-9	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	176-181
28495973-1	2017	Long-term treatment with ceftriaxone attenuates the reinstatement of cocaine seeking while increasing the function of the glutamate transporter 1 (GLT-1) and system xC- (Sxc) in the nucleus accumbens core (NAc).	nac	206-209	solute carrier family 1 member 2	Rattus norvegicus	122-145
28495973-4	2017	Intra-NAc xCT knockdown prevented ceftriaxone from attenuating reinstatement and from upregulating GLT-1 and resulted in increased surface expression of AMPA receptor subunits GluA1 and GluA2.	nac	6-9	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	186-191
28495973-5	2017	Intra-NAc GLT-1 knockdown also prevented ceftriaxone from attenuating reinstatement and from upregulating xCT expression, without affecting GluA1 and GluA2 expression.	nac	6-9	solute carrier family 1 member 2	Rattus norvegicus	10-15
28495973-6	2017	In the absence of cocaine or ceftriaxone treatment, xCT knockdown in the NAc increased the expression of both GluA1 and GluA2 without affecting GLT-1 expression while GLT-1 knockdown had no effect.	nac	73-76	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	110-115
28495973-6	2017	In the absence of cocaine or ceftriaxone treatment, xCT knockdown in the NAc increased the expression of both GluA1 and GluA2 without affecting GLT-1 expression while GLT-1 knockdown had no effect.	nac	73-76	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	120-125
28598964-2	2017	MATERIAL AND METHODS We established a rat model of heroin addiction and observed changes in the expression of BDNF, DA, dopamine receptor (DRD), dopamine transporter (DAT), and other relevant pathways in NAc.	nac	204-207	brain-derived neurotrophic factor	Rattus norvegicus	110-114
28598964-2	2017	MATERIAL AND METHODS We established a rat model of heroin addiction and observed changes in the expression of BDNF, DA, dopamine receptor (DRD), dopamine transporter (DAT), and other relevant pathways in NAc.	nac	204-207	dopamine receptor D3	Rattus norvegicus	139-142
28598964-2	2017	MATERIAL AND METHODS We established a rat model of heroin addiction and observed changes in the expression of BDNF, DA, dopamine receptor (DRD), dopamine transporter (DAT), and other relevant pathways in NAc.	nac	204-207	solute carrier family 6 member 3	Rattus norvegicus	145-165
28598964-2	2017	MATERIAL AND METHODS We established a rat model of heroin addiction and observed changes in the expression of BDNF, DA, dopamine receptor (DRD), dopamine transporter (DAT), and other relevant pathways in NAc.	nac	204-207	solute carrier family 6 member 3	Rattus norvegicus	167-170
28598964-11	2017	DRD3 and DAT increased in the NAc of the lentivirus group.	nac	30-33	dopamine receptor D3	Rattus norvegicus	0-4
28598964-11	2017	DRD3 and DAT increased in the NAc of the lentivirus group.	nac	30-33	solute carrier family 6 member 3	Rattus norvegicus	9-12
28598964-12	2017	CONCLUSIONS BDNF and DA in the NAc are involved in heroin addiction.	nac	31-34	brain-derived neurotrophic factor	Rattus norvegicus	12-16
28598964-13	2017	BDNF overexpression in NAc reduces withdrawal symptoms and craving behavior for medicine induced by environmental cues for heroin-addicted rats.	nac	23-26	brain-derived neurotrophic factor	Rattus norvegicus	0-4
28648939-2	2017	We aimed in this study to assess the immunohistochemical expression of EGFR and cytokeratin 5/6 and their ability to predict survival and response to neoadjuvant chemotherapy (NAC) among triple-negative breast cancer patients.	nac	176-179	epidermal growth factor receptor	Homo sapiens	71-75
28655941-5	2017	We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment.	nac	17-20	CD4 molecule	Homo sapiens	46-49
28655941-5	2017	We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment.	nac	17-20	CD8a molecule	Homo sapiens	51-54
28655941-5	2017	We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment.	nac	17-20	neural cell adhesion molecule 1	Homo sapiens	67-71
28648939-2	2017	We aimed in this study to assess the immunohistochemical expression of EGFR and cytokeratin 5/6 and their ability to predict survival and response to neoadjuvant chemotherapy (NAC) among triple-negative breast cancer patients.	nac	176-179	keratin 5	Homo sapiens	80-95
28648939-10	2017	EGFR expression was related to unfavorable response to NAC (p=0.036), poor OS (p=0.002) and poor DFS (p=0.003).	nac	55-58	epidermal growth factor receptor	Homo sapiens	0-4
28648939-11	2017	CK5/6 expression showed a significant association with tumor grade, unfavorable response to NAC, poor OS &amp; DFS (p=0.007, 0.048, &lt;0.001, 0.043 respectively).	nac	92-95	keratin 5	Homo sapiens	0-5
28648939-12	2017	Immunohistochemical expression of EGFR and/or CK5/6 showed a high significant association with an unfavorable response to NAC, poor DFS &amp;OS (p=0.010, 0.012, 0.030 respectively).	nac	122-125	epidermal growth factor receptor	Homo sapiens	34-38
28648939-12	2017	Immunohistochemical expression of EGFR and/or CK5/6 showed a high significant association with an unfavorable response to NAC, poor DFS &amp;OS (p=0.010, 0.012, 0.030 respectively).	nac	122-125	keratin 5	Homo sapiens	46-51
28648939-15	2017	So, targeted therapy against EGFR may be a hopeful therapy for TNBC with NAC resistance.	nac	73-76	epidermal growth factor receptor	Homo sapiens	29-33
28542130-11	2017	In addition, ROS scavenger NAC obviously reversed activation of TRPV4-induced changes of Deltapsim and mPTP opening.	nac	27-30	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	64-69
28279941-1	2017	BACKGROUND: The REMAGUS-02 multicenter randomised phase II trial showed that the addition to neoadjuvant chemotherapy (NAC) of trastuzumab in patients with localised HER2-positive breast cancer (BC) increased the pathological complete response (pCR) rate and that the addition of celecoxib in HER2-negative cases did not increase the pCR rate.	nac	119-122	erb-b2 receptor tyrosine kinase 2	Homo sapiens	166-170
28000076-10	2017	Furthermore, BCS rate was higher in the NAC group in cT2 and cT3 tumors (aOR 1.17 and 1.45, respectively; both p &lt; 0.001).	nac	40-43	cancer/testis antigen 2	Homo sapiens	53-56
28000076-10	2017	Furthermore, BCS rate was higher in the NAC group in cT2 and cT3 tumors (aOR 1.17 and 1.45, respectively; both p &lt; 0.001).	nac	40-43	cancer antigen 1	Homo sapiens	61-64
28215744-3	2017	The PS-induced LMA was defined as the distance traveled after PS administration (intraperitoneal), and the CART peptide effect was defined as the change in the PS-induced activity after bilateral intra-NAc administration of CART peptide.	nac	202-205	CART prepropeptide	Rattus norvegicus	224-228
28730768-13	2017	CONCLUSION: Changes in hormone receptor status, HER2 status and Ki-67 occurred after NAC in patients with LABC.	nac	85-88	erb-b2 receptor tyrosine kinase 2	Homo sapiens	48-52
28083910-7	2017	CONCLUSIONS: PMRT is associated with improved OS in patients with cN1 and cN2 disease after NAC and mastectomy.	nac	92-95	carnosine dipeptidase 2	Homo sapiens	74-77
28279941-1	2017	BACKGROUND: The REMAGUS-02 multicenter randomised phase II trial showed that the addition to neoadjuvant chemotherapy (NAC) of trastuzumab in patients with localised HER2-positive breast cancer (BC) increased the pathological complete response (pCR) rate and that the addition of celecoxib in HER2-negative cases did not increase the pCR rate.	nac	119-122	erb-b2 receptor tyrosine kinase 2	Homo sapiens	293-297
27629777-8	2017	(iv) CDO1 hypermethylation stratified ESCC patients" prognosis in cStage II/III for both neoadjuvant chemo(radio)therapy (NAC)-positive and NAC-negative cases.	nac	122-125	cysteine dioxygenase type 1	Homo sapiens	5-9
29108294-1	2017	Background: We aimed to develop a new nomogram to predict the probability of level 2 axillary lymph node metastasis (L-2-ALNM) in breast cancer (BC) patients treated with neoadjuvant chemotherapy (NAC).	nac	197-200	immunoglobulin kappa variable 3-15	Homo sapiens	117-125
27891614-6	2017	ER and ERL1 also prevented premature initiation of the fiber differentiation process mediated by the NAC SECONDARY WALL THICKENING PROMOTING FACTORs in the hypocotyl xylem.	nac	101-104	ERECTA-like 1	Arabidopsis thaliana	7-11
24662266-1	2017	OBJECTIVES: We conducted a phase II trial to investigate the efficacy and safety of neoadjuvant chemotherapy (NAC) comprising S-1 and cisplatin (CDDP) followed by extensive resection in the management of resectable locally advanced gastric cancer with lymph node (LN) metastases.	nac	110-113	proteasome 26S subunit, non-ATPase 1	Homo sapiens	126-129
24662266-8	2017	CONCLUSIONS: NAC with S-1 and CDDP is safe and may improve the complete resection rate in patients with metastatic LN gastric cancer.	nac	13-16	proteasome 26S subunit, non-ATPase 1	Homo sapiens	22-25
28257759-6	2017	ANA-12 also showed state-dependent effects at the NAc core, attenuating TrkB-ir in non-stress rats while reversing reduced expression in stressed rats.	nac	50-53	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	72-76
28257759-8	2017	Notably, ANA-12 showed region-specific effects on GR-ir at the NAc core and shell, with increased GR-ir in non-stress rats, although the drug attenuated stress-induced GR-ir expression only in the core portion of the NAc, while having no impact at the cingulate cortex.	nac	63-66	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	50-52
26449615-9	2017	Immunohistochemical staining demonstrated that MICA expression in tumor cells and CD16 positive cells surrounding tumors were significantly higher in the NAC group compared to that of the control group.	nac	154-157	MHC class I polypeptide-related sequence A	Homo sapiens	47-51
26449615-9	2017	Immunohistochemical staining demonstrated that MICA expression in tumor cells and CD16 positive cells surrounding tumors were significantly higher in the NAC group compared to that of the control group.	nac	154-157	Fc gamma receptor IIIa	Homo sapiens	82-86
26449615-10	2017	There was a significant correlation between NAC and MICA expression, as well as NAC and CD16 positive cell expression.	nac	44-47	MHC class I polypeptide-related sequence A	Homo sapiens	52-56
27629777-8	2017	(iv) CDO1 hypermethylation stratified ESCC patients" prognosis in cStage II/III for both neoadjuvant chemo(radio)therapy (NAC)-positive and NAC-negative cases.	nac	140-143	cysteine dioxygenase type 1	Homo sapiens	5-9
27629777-9	2017	Moreover, the CDO1 methylation level was significantly lower in cases with Grade 2/3 than in those with Grade 0/1 (P = 0.02) among cStage II/III ESCC patients with NAC.	nac	164-167	cysteine dioxygenase type 1	Homo sapiens	14-18
27629777-10	2017	Promoter DNA hypermethylation of CDO1 could be an independent prognostic factor in ESCC; it may also reflect NAC eradication of tumor cells in the primary tumors.	nac	109-112	cysteine dioxygenase type 1	Homo sapiens	33-37
27586262-9	2017	Focusing on the major obstacle regarding MIBC patient"s NAC response, we summarized the miRNAs that are deregulated and have the potential to identify the patients resistant to NAC, such as miR-34, miR-100, miR-146b and miR-9 and miR-193a-3p.	nac	177-180	microRNA 146b	Homo sapiens	207-215
27637603-10	2017	CONCLUSIONS: The presence of serum p53 antibody can be used as a novel, noninvasive predictor of the pathological tumor response to NAC with DCF in ESCC patients.	nac	132-135	tumor protein p53	Homo sapiens	35-38
29057208-8	2017	Patients with HER-2+ locally advanced breast cancer with pCR responses to NAC have improved prognoses.	nac	74-77	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-19
28959868-1	2017	Studies have shown that some plant-specific NAC (NAM, ATAF1/2, CUC2) transcription factors may increase plants resistance to stress.	nac	44-47	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	49-52
28959868-1	2017	Studies have shown that some plant-specific NAC (NAM, ATAF1/2, CUC2) transcription factors may increase plants resistance to stress.	nac	44-47	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	54-61
28959868-1	2017	Studies have shown that some plant-specific NAC (NAM, ATAF1/2, CUC2) transcription factors may increase plants resistance to stress.	nac	44-47	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	63-67
27628030-8	2017	Moreover, pretreatment of cells with 3 mM NAC reversed DET-mediated cell death and NF-kappaB inhibition, indicating that DET exerts its anticancer effects mainly through oxidative stress.	nac	42-45	nuclear factor kappa B subunit 1	Homo sapiens	83-92
27750168-11	2017	Additionally, the PI3K/AKT/mTOR pathway was activated in PM2.5-treated cells and NAC had an important inhibitory effect.	nac	81-84	AKT serine/threonine kinase 1	Rattus norvegicus	23-26
29237157-11	2017	In addition, we found that hypoxia increased ROS production and that ROS inhibitors (NAC) blocked GLI1-dependent EMT process and invasion under hypoxic conditions.	nac	85-88	GLI family zinc finger 1	Homo sapiens	98-102
26754092-3	2017	We, therefore, conducted a prospective study to evaluate the efficacy of TC NAC in HER2- primary breast cancer.	nac	76-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	83-87
26874836-5	2017	We performed a prospective multicenter study of HER-TC NAC for HER2+ primary breast cancer.	nac	55-58	erb-b2 receptor tyrosine kinase 2	Homo sapiens	63-67
27750168-11	2017	Additionally, the PI3K/AKT/mTOR pathway was activated in PM2.5-treated cells and NAC had an important inhibitory effect.	nac	81-84	mechanistic target of rapamycin kinase	Rattus norvegicus	27-31
28011867-7	2017	Their predominant expression in secondary wall-forming cells was consistent with the finding that the expression of UXS3, UXS5 and UXS6 was directly activated by the secondary wall NAC master switches.	nac	181-184	UDP-glucuronic acid decarboxylase 3	Arabidopsis thaliana	116-120
28472798-11	2017	CD4+ TILs, CD8+ TILs, and TOPOIIalpha expression were predictors of pCR and 5-year DFS of TNBC patients who were treated with NAC, and TOPOIIalpha was an independent predictor of pCR.	nac	126-129	CD4 molecule	Homo sapiens	0-3
28472798-11	2017	CD4+ TILs, CD8+ TILs, and TOPOIIalpha expression were predictors of pCR and 5-year DFS of TNBC patients who were treated with NAC, and TOPOIIalpha was an independent predictor of pCR.	nac	126-129	CD8a molecule	Homo sapiens	11-14
28472798-12	2017	CD8+ TILs were a key factor in the prediction of good 5-year OS rates of TNBC patients after taxane-anthracycline-based NAC.	nac	120-123	CD8a molecule	Homo sapiens	0-3
27903793-6	2017	5-HT2C agonists work, in part, by modulating dopamine neuron activity in the ventral tegmental area-nucleus accumbens (NAc) reward pathway.	nac	119-122	5-hydroxytryptamine receptor 2C	Homo sapiens	0-6
27903793-7	2017	We argue that activation of 5-HT2C receptors on NAc shell, GABAergic, medium spiny neurons inhibits potassium Kv1.x channels, thereby enhancing inhibitory activity via intrinsic mechanisms.	nac	48-51	5-hydroxytryptamine receptor 2C	Homo sapiens	28-34
27903793-8	2017	Together with experiments that show that addictive drugs, such as cocaine, potentiate Kv1.x channels, thereby suppressing NAc shell GABAergic activity, this hypothesis provides a mechanism by which classic hallucinogen-mediated stimulation of 5-HT2C receptors could thwart addiction.	nac	122-125	5-hydroxytryptamine receptor 2C	Homo sapiens	243-249
28913366-10	2017	PPRs to NAC had significantly reduced HLA-DR, CD40, and CD86 expression.	nac	8-11	CD40 molecule	Homo sapiens	46-50
28913366-10	2017	PPRs to NAC had significantly reduced HLA-DR, CD40, and CD86 expression.	nac	8-11	CD86 molecule	Homo sapiens	56-60
28011867-7	2017	Their predominant expression in secondary wall-forming cells was consistent with the finding that the expression of UXS3, UXS5 and UXS6 was directly activated by the secondary wall NAC master switches.	nac	181-184	UDP-XYL synthase 5	Arabidopsis thaliana	122-126
28011867-7	2017	Their predominant expression in secondary wall-forming cells was consistent with the finding that the expression of UXS3, UXS5 and UXS6 was directly activated by the secondary wall NAC master switches.	nac	181-184	UDP-XYL synthase 6	Arabidopsis thaliana	131-135
27330058-7	2016	Most signatures associated with response to NAC were proliferation associated: 90.5% (38/42) in ER+/HER2- and 63.3% (38/60) in triple-negative breast cancer (TNBC).	nac	44-47	erb-b2 receptor tyrosine kinase 2	Homo sapiens	100-104
27330058-8	2016	Proliferation-independent signatures predictive of response to NAC in ER+/HER2- breast cancer were related to immune activity, while those in TNBC comprised a diverse set of signatures, including immune, DNA damage, signaling pathways (PI3K, AKT, Ras, and EGFR), and "stemness" phenotypes.	nac	63-66	erb-b2 receptor tyrosine kinase 2	Homo sapiens	74-78
27330058-8	2016	Proliferation-independent signatures predictive of response to NAC in ER+/HER2- breast cancer were related to immune activity, while those in TNBC comprised a diverse set of signatures, including immune, DNA damage, signaling pathways (PI3K, AKT, Ras, and EGFR), and "stemness" phenotypes.	nac	63-66	epidermal growth factor receptor	Homo sapiens	256-260
27748881-3	2016	The objective of this study was to identify the influence of the expression status of the CSC markers CD44 and CD133 on chemotherapeutic efficacy and prognosis in ESCC patients who underwent radical esophagectomy after neoadjuvant chemotherapy (NAC).	nac	245-248	CD44 molecule (Indian blood group)	Homo sapiens	102-106
27716627-5	2016	ERBB2 copy number values obtained by MIP or NGS/NAC were tightly correlated with ERBB2 copy number values obtained by conventional FISH (rs = 0.940 and rs = 0.894, P &lt; 0.001).	nac	48-51	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
27748881-6	2016	The percentages of CD44-positive cells and CD133-positive cells in specimens were increased after NAC.	nac	98-101	CD44 molecule (Indian blood group)	Homo sapiens	19-23
27748881-6	2016	The percentages of CD44-positive cells and CD133-positive cells in specimens were increased after NAC.	nac	98-101	prominin 1	Homo sapiens	43-48
27581532-1	2016	To assess the association of the programmed cell death ligand 1 (PD-L1) with cisplatin-based neo-adjuvant chemotherapy (NAC) response, we investigated the level of PD-L1 and found increased PD-L1 expression in chemo-resistant tumors compared with chemo-sensitive tumors according to RNA-Seq analysis.	nac	120-123	CD274 molecule	Homo sapiens	33-63
28105226-17	2016	NAC was observed to be significantly more effective in the low EGFL7 expression level group (P&lt;0.001), as compared with the high expression level group.	nac	0-3	EGF like domain multiple 7	Homo sapiens	63-68
28105226-18	2016	The results suggest that the expression levels of EGFL7 may be a potential predictive marker of the efficacy of NAC for the treatment of locally advanced uterine cervical cancer.	nac	112-115	EGF like domain multiple 7	Homo sapiens	50-55
27933076-2	2016	Here, we reported the biological functions of TaNAC2D, a stress-related NAC (NAM, ATAF, and CUC) gene from wheat.	nac	48-51	NAC domain-containing protein 20	Triticum aestivum	77-80
26464007-10	2016	HER2-enriched tumors and young age (&lt;40 years) were significant risk factors for recurrence at the NAC.	nac	102-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
27581532-1	2016	To assess the association of the programmed cell death ligand 1 (PD-L1) with cisplatin-based neo-adjuvant chemotherapy (NAC) response, we investigated the level of PD-L1 and found increased PD-L1 expression in chemo-resistant tumors compared with chemo-sensitive tumors according to RNA-Seq analysis.	nac	120-123	CD274 molecule	Homo sapiens	65-70
27581532-1	2016	To assess the association of the programmed cell death ligand 1 (PD-L1) with cisplatin-based neo-adjuvant chemotherapy (NAC) response, we investigated the level of PD-L1 and found increased PD-L1 expression in chemo-resistant tumors compared with chemo-sensitive tumors according to RNA-Seq analysis.	nac	120-123	CD274 molecule	Homo sapiens	164-169
27581532-1	2016	To assess the association of the programmed cell death ligand 1 (PD-L1) with cisplatin-based neo-adjuvant chemotherapy (NAC) response, we investigated the level of PD-L1 and found increased PD-L1 expression in chemo-resistant tumors compared with chemo-sensitive tumors according to RNA-Seq analysis.	nac	120-123	CD274 molecule	Homo sapiens	164-169
27581532-2	2016	In a cohort of 92 patients with NAC, the positive staining of PD-L1 was correlated with TNM stage, lower sensitive-response rates and shorter overall survival rates.	nac	32-35	CD274 molecule	Homo sapiens	62-67
27581532-9	2016	The high expression of PD-L1 after NAC could be an indication of therapeutic resistance and poor prognosis in patients with non-small-cell lung cancer.	nac	35-38	CD274 molecule	Homo sapiens	23-28
27080586-1	2016	PURPOSE: To predict pathological response of breast cancer to neoadjuvant chemotherapy (NAC) based on quantitative, multiregion analysis of dynamic contrast enhancement magnetic resonance imaging (DCE-MRI).	nac	88-91	24-dehydrocholesterol reductase	Homo sapiens	197-200
27080586-11	2016	CONCLUSION: The heterogeneity of the tumor subregion associated with fast washout on DCE-MRI predicted pathological response to NAC in breast cancer.	nac	128-131	24-dehydrocholesterol reductase	Homo sapiens	85-88
27882235-3	2016	The present study aimed to use molecular approaches to evaluate the feasibility and accuracy of SLNB in patients treated with NAC prior to SLN mapping and surgery.	nac	126-129	sarcolipin	Homo sapiens	96-99
26910473-9	2016	CONCLUSION: The TN and HER2(T-) subtypes predict higher rates of IBTR and LRR after NAC and BCT.	nac	84-87	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
26873872-0	2016	Coupling of the non-amyloid-component (NAC) domain and the KTK(E/Q)GV repeats stabilize the alpha-synuclein fibrils.	nac	39-42	synuclein alpha	Homo sapiens	92-107
26873872-9	2016	The organization of the repeat K(58)T(59)K(60)E(61)Q(62)V(63) between the beta2 and beta3 layers significantly affects the stability of the non-amyloid-component (NAC) domain.	nac	163-166	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	74-89
27296152-10	2016	Our findings demonstrate a novel NAc VTA circuit responsible for the behavioral and neuronal effects of CBD within the mesolimbic system via functional interactions with serotonergic 5-HT1A receptor signaling.	nac	33-36	5-hydroxytryptamine receptor 1A	Rattus norvegicus	183-189
27777881-12	2016	Higher counts of CD3, CD4, CD8 and FOXP3 in pre-NAC samples had longer disease-free-survival (DFS).	nac	48-51	forkhead box P3	Homo sapiens	35-40
27777881-14	2016	Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR.	nac	38-41	CD8a molecule	Homo sapiens	16-19
27777881-14	2016	Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR.	nac	38-41	CD4 molecule	Homo sapiens	20-23
27777881-15	2016	Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS.	nac	40-43	CD4 molecule	Homo sapiens	16-19
27777881-15	2016	Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS.	nac	40-43	forkhead box P3	Homo sapiens	20-25
27777881-16	2016	Higher counts of CD4 in post-NAC samples were associated with pCR.	nac	29-32	CD4 molecule	Homo sapiens	17-20
27677313-3	2016	RESULTS: Based on ROC curves analysis, CA125 &lt;= 75 UI/ml and HE4 &lt;= 252 pmol/L after the 3rd cycles of NAC, with a sensitivity of 93.7 % and a specificity of 92.3 % (PPV = 93.7 % and NPV = 92.3 %), offered the best combination for predicting optimal cytoreduction.	nac	109-112	mucin 16, cell surface associated	Homo sapiens	39-44
27677313-3	2016	RESULTS: Based on ROC curves analysis, CA125 &lt;= 75 UI/ml and HE4 &lt;= 252 pmol/L after the 3rd cycles of NAC, with a sensitivity of 93.7 % and a specificity of 92.3 % (PPV = 93.7 % and NPV = 92.3 %), offered the best combination for predicting optimal cytoreduction.	nac	109-112	WAP four-disulfide core domain 2	Homo sapiens	64-67
27216423-1	2016	NAC (NAM, ATAF1/2, CUC2) transcription factors are plant-specific and have diverse functions in many plant developmental processes and responses to stress.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	10-15
27652518-5	2016	The 3D-CEUS score, DCE-MRI score, MVD and VEGF significantly decreased (P &lt; 0.0001) after NAC.	nac	93-96	vascular endothelial growth factor A	Homo sapiens	42-46
27216423-2	2016	In our previous study, we found that the expression of ATAF1, an Arabidopsis NAC gene, was obviously induced by high-salinity and abscisic acid (ABA).	nac	77-80	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	55-60
27067040-10	2016	Only lymph vascular invasion, grading 3, luminal-like, and HER2/like BC subtype showed predictive and prognostic impact in patients with BC receiving NAC.	nac	150-153	erb-b2 receptor tyrosine kinase 2	Homo sapiens	59-63
27495815-11	2016	CONCLUSIONS: MRI after NAC in ER-positive/HER2-negative tumors may be predictive of recurrence-free survival.	nac	23-26	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-46
27168116-1	2016	Much evidence suggests that intra-nucleus accumbens (NAc) CART peptide (CART 55-102) injection inhibits locomotor activity (LMA) when there is an increase in the release and activity of dopamine (DA) in the NAc.	nac	53-56	CART prepropeptide	Rattus norvegicus	58-62
27168116-1	2016	Much evidence suggests that intra-nucleus accumbens (NAc) CART peptide (CART 55-102) injection inhibits locomotor activity (LMA) when there is an increase in the release and activity of dopamine (DA) in the NAc.	nac	53-56	CART prepropeptide	Rattus norvegicus	72-76
27168116-1	2016	Much evidence suggests that intra-nucleus accumbens (NAc) CART peptide (CART 55-102) injection inhibits locomotor activity (LMA) when there is an increase in the release and activity of dopamine (DA) in the NAc.	nac	207-210	CART prepropeptide	Rattus norvegicus	58-62
27168116-1	2016	Much evidence suggests that intra-nucleus accumbens (NAc) CART peptide (CART 55-102) injection inhibits locomotor activity (LMA) when there is an increase in the release and activity of dopamine (DA) in the NAc.	nac	207-210	CART prepropeptide	Rattus norvegicus	72-76
27168116-5	2016	Therefore, in this study, we have examined the effect of injections of CART peptide (2.5mug) into the NAc core on the locomotor effects of caffeine in male Sprague-Dawley rats.	nac	102-105	CART prepropeptide	Rattus norvegicus	71-75
27168116-10	2016	Our study supports the hypothesis that the inhibitory effects of CART peptide in the NAc may be exerted only under conditions of increased extracellular DA release and activity in this region.	nac	85-88	CART prepropeptide	Rattus norvegicus	65-69
27168116-11	2016	Our results also suggest that intra-NAc CART 55-102 does not generally inhibit increases in LMA due to all drugs, but has a more specific inhibitory effect on dopaminergic neurotransmission.	nac	36-39	CART prepropeptide	Rattus norvegicus	40-44
27085481-1	2016	NAC (NAM, ATAF1/2, and CUC2) transcription factors are known to play important roles in responses to abiotic stresses in plants.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	5-8
27278091-4	2016	From the TCR sequencing results, we calculated the diversity index of the TCRbeta chain and found that clonal expansion of TILs could be detected in patients who showed CR or PR to NAC.	nac	181-184	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	74-81
27278091-5	2016	Noteworthy, the diversity of TCR was further reduced in the post-NAC tumors of CR patients.	nac	65-68	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	29-32
27278091-6	2016	Our quantitative RT-PCR also showed that expression ratio of CD8/Foxp3 was significantly elevated in the post-NAC tumors of CR cases (p=0.0032), indicating that antitumor T cells were activated and enriched in these tumors.	nac	110-113	CD8a molecule	Homo sapiens	61-64
27278091-6	2016	Our quantitative RT-PCR also showed that expression ratio of CD8/Foxp3 was significantly elevated in the post-NAC tumors of CR cases (p=0.0032), indicating that antitumor T cells were activated and enriched in these tumors.	nac	110-113	forkhead box P3	Homo sapiens	65-70
27085481-1	2016	NAC (NAM, ATAF1/2, and CUC2) transcription factors are known to play important roles in responses to abiotic stresses in plants.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	10-17
27085481-1	2016	NAC (NAM, ATAF1/2, and CUC2) transcription factors are known to play important roles in responses to abiotic stresses in plants.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	23-27
27382351-8	2016	TNF-alpha induced ROS formation, phosphorylation of NF-kappaB p65 and ERK, and LOX-1 expression, which were suppressed by rotenone, DPI, NAC, and CPT.	nac	137-140	tumor necrosis factor	Rattus norvegicus	0-9
27382351-8	2016	TNF-alpha induced ROS formation, phosphorylation of NF-kappaB p65 and ERK, and LOX-1 expression, which were suppressed by rotenone, DPI, NAC, and CPT.	nac	137-140	synaptotagmin 1	Rattus norvegicus	62-65
27382351-8	2016	TNF-alpha induced ROS formation, phosphorylation of NF-kappaB p65 and ERK, and LOX-1 expression, which were suppressed by rotenone, DPI, NAC, and CPT.	nac	137-140	Eph receptor B1	Rattus norvegicus	70-73
27382351-8	2016	TNF-alpha induced ROS formation, phosphorylation of NF-kappaB p65 and ERK, and LOX-1 expression, which were suppressed by rotenone, DPI, NAC, and CPT.	nac	137-140	oxidized low density lipoprotein receptor 1	Rattus norvegicus	79-84
27382351-10	2016	CPT and NAC suppressed TNF-alpha-induced LOX-1 expression and phosphorylation of NF-kappaB p65 and ERK in rat aorta.	nac	8-11	tumor necrosis factor	Rattus norvegicus	23-32
27382351-10	2016	CPT and NAC suppressed TNF-alpha-induced LOX-1 expression and phosphorylation of NF-kappaB p65 and ERK in rat aorta.	nac	8-11	oxidized low density lipoprotein receptor 1	Rattus norvegicus	41-46
27382351-10	2016	CPT and NAC suppressed TNF-alpha-induced LOX-1 expression and phosphorylation of NF-kappaB p65 and ERK in rat aorta.	nac	8-11	synaptotagmin 1	Rattus norvegicus	91-94
27382351-10	2016	CPT and NAC suppressed TNF-alpha-induced LOX-1 expression and phosphorylation of NF-kappaB p65 and ERK in rat aorta.	nac	8-11	Eph receptor B1	Rattus norvegicus	99-102
27015293-8	2016	The patients with positive PD-L1 expression had a significantly higher rate of NAC history (P = 0.0139), but those with positive PD-L2 expression did not have a significantly high rate of NAC history (P = 0.6127).	nac	79-82	CD274 molecule	Homo sapiens	27-32
27362808-4	2016	Here we show a strong correlation between miR-205 expression and chemosensitivtiy to TAC (docetaxol, doxorubicin plus cyclophosphamide), a widely-used neoadjuvant chemotherapy (NAC) regimen, for breast cancer patients.	nac	177-180	microRNA 205	Homo sapiens	42-49
27362808-5	2016	High level of miR-205 predicted better response to TAC regimen NAC in breast cancer patients.	nac	63-66	microRNA 205	Homo sapiens	14-21
27362808-9	2016	Consistently, low VEGFA and FGF2 expression correlated with better response to NAC in breast cancer patients.	nac	79-82	vascular endothelial growth factor A	Homo sapiens	18-23
27362808-9	2016	Consistently, low VEGFA and FGF2 expression correlated with better response to NAC in breast cancer patients.	nac	79-82	fibroblast growth factor 2	Homo sapiens	28-32
27132084-6	2016	The mRNA levels of BDNF and CREB were significantly decreased, then gradually recovered over 24h to maximum levels in the hippocampus (CA1 region), prefrontal cortex (PFC), central amygdaloid nuclei (AG), shell of accumbens nucleus (NAC), periaqueductal gray (PAG) and ventral tegmental area, except for the ventral tegmental area (VTA).	nac	233-236	brain-derived neurotrophic factor	Rattus norvegicus	19-23
27132084-6	2016	The mRNA levels of BDNF and CREB were significantly decreased, then gradually recovered over 24h to maximum levels in the hippocampus (CA1 region), prefrontal cortex (PFC), central amygdaloid nuclei (AG), shell of accumbens nucleus (NAC), periaqueductal gray (PAG) and ventral tegmental area, except for the ventral tegmental area (VTA).	nac	233-236	cAMP responsive element binding protein 1	Rattus norvegicus	28-32
27282818-7	2016	TFF3 significantly augmented the increment of the dopamine concentration in the NAc and the activity of the mTOR signalling pathway induced by acute cocaine exposure (10 mg/kg, i.p.)	nac	80-83	trefoil factor 3	Rattus norvegicus	0-4
27282818-9	2016	The Intra-NAc shell infusion of rapamycin blocked TFF3-induced hyperactivity in cocaine-treatment rats.	nac	10-13	trefoil factor 3	Rattus norvegicus	50-54
27282818-11	2016	Furthermore, the findings indicated that mTOR signalling pathway in the NAc shell is important for TFF3-induced enhancement on the cocaine-induced behavioral changes.	nac	72-75	mechanistic target of rapamycin kinase	Rattus norvegicus	41-45
27282818-11	2016	Furthermore, the findings indicated that mTOR signalling pathway in the NAc shell is important for TFF3-induced enhancement on the cocaine-induced behavioral changes.	nac	72-75	trefoil factor 3	Rattus norvegicus	99-103
27441095-5	2016	Functional capacity of iT-reg was assessed using 3H-Thymidine incorporation and IFNgamma production of non-adherent T cells (NAC) in the presence or absence of iT-reg in corresponding culture supernatants in response to TCR stimulation.	nac	125-128	regenerating family member 1 alpha	Homo sapiens	26-29
26382845-5	2016	RESULTS: The distribution of BEC 1/2/3/4 was 25/46/18/11 % before and 78/20/2/0 % after NAC.	nac	88-91	potassium voltage-gated channel subfamily H member 3	Homo sapiens	29-40
27441095-9	2016	Further, MTB H37RvL induced CD4+CD25hi+ Foxp3+ iT-reg suppressed 3H-Thymidine incorporation and IFNgamma production of non-adherent T cells (NAC) in response to TCR stimulation.	nac	141-144	metallothionein 1J, pseudogene	Homo sapiens	9-12
27441095-9	2016	Further, MTB H37RvL induced CD4+CD25hi+ Foxp3+ iT-reg suppressed 3H-Thymidine incorporation and IFNgamma production of non-adherent T cells (NAC) in response to TCR stimulation.	nac	141-144	CD4 molecule	Homo sapiens	28-31
27441095-9	2016	Further, MTB H37RvL induced CD4+CD25hi+ Foxp3+ iT-reg suppressed 3H-Thymidine incorporation and IFNgamma production of non-adherent T cells (NAC) in response to TCR stimulation.	nac	141-144	forkhead box P3	Homo sapiens	40-45
27441095-9	2016	Further, MTB H37RvL induced CD4+CD25hi+ Foxp3+ iT-reg suppressed 3H-Thymidine incorporation and IFNgamma production of non-adherent T cells (NAC) in response to TCR stimulation.	nac	141-144	regenerating family member 1 alpha	Homo sapiens	50-53
27399922-4	2016	Purpose The present study evaluated the association between EZH2 expression and response to NAC, and its correlation with HER2 overexpression, estrogen and progesterone receptors (ER, PR) and Ki-67 proliferation index.	nac	92-95	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	60-64
27154986-0	2016	Residual mucin and response after neoadjuvant chemotherapy (NAC) in breast cancer.	nac	60-63	LOC100508689	Homo sapiens	9-14
27313469-1	2016	BACKGROUND: The addition of human epidermal growth factor receptor 2 (Her2) therapies to neoadjuvant chemotherapy (NAC) during treatment of Her2-positive breast cancer has been proposed as an effective way to improve the prognosis.	nac	115-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-68
27313469-1	2016	BACKGROUND: The addition of human epidermal growth factor receptor 2 (Her2) therapies to neoadjuvant chemotherapy (NAC) during treatment of Her2-positive breast cancer has been proposed as an effective way to improve the prognosis.	nac	115-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	70-74
27313469-1	2016	BACKGROUND: The addition of human epidermal growth factor receptor 2 (Her2) therapies to neoadjuvant chemotherapy (NAC) during treatment of Her2-positive breast cancer has been proposed as an effective way to improve the prognosis.	nac	115-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	140-144
28247605-10	2016	Conclusion: Patients with HR altered from positive to negative after NAC may still gain benefit from AET.	nac	69-72	nuclear receptor subfamily 4 group A member 1	Homo sapiens	26-28
26861597-11	2016	CONCLUSIONS: In the largest reported analysis of RT for cN1 patients treated with NAC, PMRT was associated with improved OS for all pathologic nodal subgroups.	nac	82-85	5'-nucleotidase, cytosolic IA	Homo sapiens	56-59
26945566-8	2016	Use of NAC increased from 0.5% to 2.3% for cT1 tumors, from 2.8% to 27.0% for cT2, from 30.6% to 70.9% for cT3, and from 40.5% to 58.1% for cT4 tumors (p &lt; 0.001).	nac	7-10	cardiotrophin 1	Homo sapiens	43-46
26945566-8	2016	Use of NAC increased from 0.5% to 2.3% for cT1 tumors, from 2.8% to 27.0% for cT2, from 30.6% to 70.9% for cT3, and from 40.5% to 58.1% for cT4 tumors (p &lt; 0.001).	nac	7-10	cancer/testis antigen 2	Homo sapiens	78-81
26945566-8	2016	Use of NAC increased from 0.5% to 2.3% for cT1 tumors, from 2.8% to 27.0% for cT2, from 30.6% to 70.9% for cT3, and from 40.5% to 58.1% for cT4 tumors (p &lt; 0.001).	nac	7-10	cancer antigen 1	Homo sapiens	107-110
26945566-14	2016	The administration of NAC and the percentage of BCS increased over the past decade, especially in cT2 tumors.	nac	22-25	cancer/testis antigen 2	Homo sapiens	98-101
27222180-7	2016	NAC obviously reduced cellular ROS level stimulated by PA (7782.15+-2.87 vs 5445.6+-1.17, P=0.00) and suppressed the expressions of NLRP3, ASC and caspase-1.	nac	0-3	NLR family, pyrin domain containing 3	Mus musculus	132-137
27210086-2	2016	Thirteen HER2-positive patients received NAC containing nabPTX or paclitaxel between June 2008 and December 2014.	nac	41-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-13
27210086-3	2016	Of 13 HER2-positive patients, those who received nabPTX-containing NAC showed an 85.7% (6/7) pathological complete response (pCR) rate, whereas those who received paclitaxel-containing NAC showed a pCR rate of 50.0% (3/6).	nac	67-70	erb-b2 receptor tyrosine kinase 2	Homo sapiens	6-10
27222180-7	2016	NAC obviously reduced cellular ROS level stimulated by PA (7782.15+-2.87 vs 5445.6+-1.17, P=0.00) and suppressed the expressions of NLRP3, ASC and caspase-1.	nac	0-3	steroid sulfatase	Mus musculus	139-142
27222180-7	2016	NAC obviously reduced cellular ROS level stimulated by PA (7782.15+-2.87 vs 5445.6+-1.17, P=0.00) and suppressed the expressions of NLRP3, ASC and caspase-1.	nac	0-3	caspase 1	Mus musculus	147-156
26338270-9	2016	Among premenopausal, but not postmenopausal patients, a significant decrease in PgR expression levels was detected in breast cancers of patients who attained clinical response (pre-NAC 50, 0-100 %, post-NAC 5, 0-20 %; P = 0.0003).	nac	181-184	progesterone receptor	Homo sapiens	80-83
27064979-12	2016	This is one of the early reports on miR-3200 in response to treatment in breast cancer, as serum levels of miR-3200 found to decline during NAC, and higher serum levels were associated with lower residual breast cancer burden and relapse rates at time of diagnosis.	nac	140-143	microRNA 3200	Homo sapiens	36-44
27064979-12	2016	This is one of the early reports on miR-3200 in response to treatment in breast cancer, as serum levels of miR-3200 found to decline during NAC, and higher serum levels were associated with lower residual breast cancer burden and relapse rates at time of diagnosis.	nac	140-143	microRNA 3200	Homo sapiens	107-115
27069172-1	2016	AIM: Our objective was to evaluate the kinetic parameters of serum CA125 during neoadjuvant platinum-based chemotherapy (NAC), in patients with epithelial ovarian cancer, in order to identify a surrogate marker of sensitivity to platinum.	nac	121-124	mucin 16, cell surface associated	Homo sapiens	67-72
27069172-5	2016	A CA125 level after the 3rd NAC cycle &lt;35 UI/ml was significantly associated with improved overall survival (OS) and relapse-free survival (RFS).	nac	28-31	mucin 16, cell surface associated	Homo sapiens	2-7
27069172-6	2016	In the multivariate model, patients with a CA125 level after the 3rd NAC cycle &gt;35 UI/ml were 3.8-times more at risk for PFI &lt;12 months (95% CI=1.7-8.5, p&lt;0.001).	nac	69-72	mucin 16, cell surface associated	Homo sapiens	43-48
27069172-7	2016	CONCLUSION: A CA125 level after the 3rd NAC &lt;35 UI/ml is an independent predictor for tumor platinum-sensitivity.	nac	40-43	mucin 16, cell surface associated	Homo sapiens	14-19
27143933-2	2016	The aim of the present study was to investigate the protein expression of AEG-1 in patients with epithelial ovarian cancer (EOC) who underwent debulking surgery after neoadjuvant chemotherapy (NAC).	nac	193-196	metadherin	Homo sapiens	74-79
27143933-6	2016	Furthermore, AEG-1 expression was significantly higher in NAC-resistant disease than in NAC-sensitive disease (P&lt;0.05).	nac	58-61	metadherin	Homo sapiens	13-18
27143933-6	2016	Furthermore, AEG-1 expression was significantly higher in NAC-resistant disease than in NAC-sensitive disease (P&lt;0.05).	nac	88-91	metadherin	Homo sapiens	13-18
27077652-6	2016	A set of 10 genes (ACS2, COP1, CYC-B, RIN, MSH2, NAC-NOR, PHOT1, PHYA, PHYB and PSY1) involved in various plant developmental processes were screened for SNP polymorphism by EcoTILLING.	nac	49-52	phytoene synthase 1, chloroplastic	Solanum lycopersicum	80-84
26338270-9	2016	Among premenopausal, but not postmenopausal patients, a significant decrease in PgR expression levels was detected in breast cancers of patients who attained clinical response (pre-NAC 50, 0-100 %, post-NAC 5, 0-20 %; P = 0.0003).	nac	203-206	progesterone receptor	Homo sapiens	80-83
26148813-11	2016	These results provide novel evidence that blood MAOA expression predicts alcohol consumption and that heavy alcohol use is linked to low MAOA expression in both the blood and NAc core.	nac	175-178	monoamine oxidase A	Macaca mulatta	137-141
25636205-7	2016	ERCC2 missense mutations, recently found associated with response to NAC, were more common in complete responders; however, this association did not reach statistical significance in our cohort.	nac	69-72	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	0-5
27041736-2	2016	We hypothesized that breast cancer cells overexpressing epithelial cell adhesion molecule (EpCAM) could be resistant to NAC, contributing to a poor prognosis.	nac	120-123	epithelial cell adhesion molecule	Homo sapiens	56-89
27041736-2	2016	We hypothesized that breast cancer cells overexpressing epithelial cell adhesion molecule (EpCAM) could be resistant to NAC, contributing to a poor prognosis.	nac	120-123	epithelial cell adhesion molecule	Homo sapiens	91-96
27041736-7	2016	Patients with high EpCAM expression before and after NAC (high-to-high group) showed worse pathological and clinical responses (P = 0.008 and &lt;0.001, respectively) than the patients with high and low EpCAM expression before and after NAC, respectively (high-to-low group).	nac	53-56	epithelial cell adhesion molecule	Homo sapiens	19-24
27041736-7	2016	Patients with high EpCAM expression before and after NAC (high-to-high group) showed worse pathological and clinical responses (P = 0.008 and &lt;0.001, respectively) than the patients with high and low EpCAM expression before and after NAC, respectively (high-to-low group).	nac	237-240	epithelial cell adhesion molecule	Homo sapiens	19-24
27041736-9	2016	Our findings imply that higher levels of EpCAM in breast cancer may be associated with poor response to NAC via a potential chemoresistant effect.	nac	104-107	epithelial cell adhesion molecule	Homo sapiens	41-46
26987314-2	2016	The nucleic acid chaperone (NAC) activity is considered necessary to retroviral Gag functions, but so far, NAC activity has only been confirmed for HIV-1 and RSV Gag polyproteins.	nac	28-31	Pr55(Gag)	Human immunodeficiency virus 1	80-83
26987314-2	2016	The nucleic acid chaperone (NAC) activity is considered necessary to retroviral Gag functions, but so far, NAC activity has only been confirmed for HIV-1 and RSV Gag polyproteins.	nac	107-110	Pr55(Gag)	Human immunodeficiency virus 1	162-165
26987314-3	2016	The nucleocapsid (NC) domain of Gag is proposed to be crucial for interactions with nucleic acids and NAC activity.	nac	102-105	Pr55(Gag)	Human immunodeficiency virus 1	32-35
26987314-4	2016	The major function of matrix (MA) domain is targeting and binding of Gag to the plasma membrane but MA can also interact with RNA and influence NAC activity of Gag.	nac	144-147	Pr55(Gag)	Human immunodeficiency virus 1	160-163
26987314-5	2016	Here, we characterize RNA binding properties and NAC activity of HIV-2 MA and Gag, lacking p6 domain (GagDeltap6) and discuss potential contribution of NC and MA domains to HIV-2 GagDeltap6 functions and interactions with RNA.	nac	49-52	Pr55(Gag)	Human immunodeficiency virus 1	78-81
26987314-13	2016	The role of the MA domain in the NAC activity of Gag may differ significantly between HIV-1 and HIV-2.	nac	33-36	Pr55(Gag)	Human immunodeficiency virus 1	49-52
26987314-16	2016	Our data on HIV-2 indicate that the role of the MA domain in the NAC activity of Gag differs not only between, but also within, retroviral genera.	nac	65-68	Pr55(Gag)	Human immunodeficiency virus 1	81-84
25636205-8	2016	We conclude that ERBB2 missense mutations characterize a subgroup of MIBC patients with an excellent response to NAC.	nac	113-116	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-22
25636205-10	2016	We found that mutations in the gene ERBB2 are exclusively present in patients responding to NAC.	nac	92-95	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-41
26577828-4	2016	In this study, we assessed the potential of serum HGF as a prognostic biomarker for NAC efficacy.	nac	84-87	hepatocyte growth factor	Homo sapiens	50-53
26869263-0	2016	Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation.	nac	85-88	ubiquitin protein ligase E3A	Homo sapiens	8-13
24193048-5	2016	T-2 toxin induced acute cardiotoxicity in rats and characterized by significant (p &lt; 0.05) elevation of serum troponin I, creatine kinase (CK) isoenzyme MB, CK isoenzyme NAC, and lactate dehydrogenase as compared to control rats.	nac	173-176	brachyury 2	Rattus norvegicus	0-3
27467953-10	2016	DISCUSSION: To our knowledge, this is the first report in bladder cancer showing that the CD8 to Treg TIL density in the pre-treatment tissues is predictive for conventional NAC response.	nac	174-177	CD8a molecule	Homo sapiens	90-93
26637198-10	2016	A response grading system based on pathological parameters may be useful to predict both progression-free and overall survival in bulky stage Ib2 and IIa cervical squamous cell cancer patients treated with NAC.	nac	206-209	mitogen-activated protein kinase 8 interacting protein 2	Homo sapiens	142-145
26707593-12	2016	Multivariable logistic regression analysis revealed that younger age, &gt;= cT3, &gt;= cN1 and treatment in academic/teaching hospitals were associated with NAC or IC (all p &lt; 0.05).	nac	157-160	5'-nucleotidase, cytosolic IA	Homo sapiens	87-90
26851002-13	2016	In both pre-NAC TURBT and post-NAC RC specimens, a CTR1 expression score of 3+ correlated with pathological response (p=0.0076 and p=0.023, respectively).	nac	12-15	solute carrier family 31 member 1	Homo sapiens	51-55
26851002-13	2016	In both pre-NAC TURBT and post-NAC RC specimens, a CTR1 expression score of 3+ correlated with pathological response (p=0.0076 and p=0.023, respectively).	nac	31-34	solute carrier family 31 member 1	Homo sapiens	51-55
26152740-1	2016	PURPOSE: Most hormone receptor (HR)(+)/HER2(-) breast cancer patients respond unfavorably to neoadjuvant chemotherapy (NAC); however, genomic tests may identify those patients who are likely to benefit.	nac	119-122	nuclear receptor subfamily 4 group A member 1	Homo sapiens	14-30
26152740-3	2016	We then determined whether Prosigna risk of relapse (ROR) score and intrinsic subtype predicted response to NAC in HR(+)/HER2(-) patients using CNB samples.	nac	108-111	erb-b2 receptor tyrosine kinase 2	Homo sapiens	121-125
26152740-10	2016	Prosigna results obtained from the HR(+)/HER2(-) patient samples showed that both ROR (P = 0.047) and intrinsic subtype (OR LumA vs. non-LumA = 0.341, P = 0.037) were significant predictors of response to NAC.	nac	205-208	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	82-85
26152740-11	2016	CONCLUSIONS: Prosigna ROR and intrinsic subtype are readily obtained from CNB samples in normal practice and reliably predict response to NAC in HR(+)/HER2(-) patients.	nac	138-141	long intergenic non-protein coding RNA, regulator of reprogramming	Homo sapiens	22-25
26152740-11	2016	CONCLUSIONS: Prosigna ROR and intrinsic subtype are readily obtained from CNB samples in normal practice and reliably predict response to NAC in HR(+)/HER2(-) patients.	nac	138-141	erb-b2 receptor tyrosine kinase 2	Homo sapiens	151-155
28723397-3	2016	We investigated the impact of cytotoxic neoadjuvant chemotherapy (NAC) on PDL1 expression in UC.	nac	66-69	CD274 molecule	Homo sapiens	74-78
26706696-3	2016	We have demonstrated that the mechanism of action by which ceftriaxone attenuates reinstatement involves increased NAc GLT-1 expression and a reduction in NAc glutamate efflux during reinstatement.	nac	115-118	solute carrier family 1 member 2	Homo sapiens	119-124
26706696-8	2016	GluA1 was reduced in the NAc by both doses of ceftriaxone while GluA2 expression was unchanged, indicating that ceftriaxone altered AMPA subunit composition following cocaine.	nac	25-28	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	0-5
26706696-11	2016	Furthermore, increasing NAc GLT-1 protein expression is not sufficient to attenuate glutamate efflux.	nac	24-27	solute carrier family 1 member 2	Homo sapiens	28-33
28723397-5	2016	PDL1 expression was significantly higher in post-NAC specimens than in matched pre-NAC specimens (p=0.0235, Wilcoxen"s signed rank test).	nac	49-52	CD274 molecule	Homo sapiens	0-4
28723397-5	2016	PDL1 expression was significantly higher in post-NAC specimens than in matched pre-NAC specimens (p=0.0235, Wilcoxen"s signed rank test).	nac	83-86	CD274 molecule	Homo sapiens	0-4
28723397-6	2016	PDL1 expression in pre-NAC tissue did not correlate with clinical or pathologic stage but was associated with recurrence free survival.	nac	23-26	CD274 molecule	Homo sapiens	0-4
28723397-7	2016	The increase in PDL1 expression following NAC in our limited cohort has potential to guide optimal combination and sequencing of immune and cytotoxic therapies in UC patients.	nac	42-45	CD274 molecule	Homo sapiens	16-20
26764325-8	2016	The amounts of SAC, NAc-SAC, and NAc-SACS excreted in urine over 24 h were 2.9%, 80%, and 11% of the orally administered SAC, respectively.	nac	33-36	sacsin molecular chaperone	Rattus norvegicus	37-41
26764325-10	2016	These results collectively suggested that SAC was ultimately metabolized to NAc-SAC and NAc-SACS through the cycles of urinary excretion, renal reabsorption, and systemic recirculation.	nac	88-91	sacsin molecular chaperone	Rattus norvegicus	92-96
26812961-3	2016	Here, we demonstrated that OsSWN1, the orthologue of the rice NAC Secondary-wall Thickening factor (NST) transcription factor, effectively enhanced secondary cell wall formation in the Arabidopsis inflorescence stem and poplar (Populus tremulaxPopulus tremuloides) stem when expressed by the Arabidopsis NST3 promoter.	nac	62-65	NAC domain containing protein 12	Arabidopsis thaliana	304-308
26876074-1	2016	OBJECTIVE: To investigate the predictive factors of pathological complete response (pCR) in primary human epidermal growth factor receptor 2 (HER2)-positive breast cancer treated with trastuzumab-based neoadjuvant chemotherapy (NAC).	nac	228-231	erb-b2 receptor tyrosine kinase 2	Homo sapiens	106-140
26876074-1	2016	OBJECTIVE: To investigate the predictive factors of pathological complete response (pCR) in primary human epidermal growth factor receptor 2 (HER2)-positive breast cancer treated with trastuzumab-based neoadjuvant chemotherapy (NAC).	nac	228-231	erb-b2 receptor tyrosine kinase 2	Homo sapiens	142-146
26876074-2	2016	METHODS: Totally 101 patients of primary HER2-positive breast cancer treated with trastuzumab-based NAC and subsequent curative surgical therapy in the Breast Disease Center of Peking University First Hospital from September 2007 to December 2014 were retrospectively reviewed.	nac	100-103	erb-b2 receptor tyrosine kinase 2	Homo sapiens	41-45
26876074-7	2016	CONCLUSION: Tumor-infiltrating lymphocytes-positive and HR-negative were independent predictive factors of pCR in primary HER2-positive breast cancer treated with trastuzumab-based NAC.	nac	181-184	nuclear receptor subfamily 4 group A member 1	Homo sapiens	56-58
26876074-7	2016	CONCLUSION: Tumor-infiltrating lymphocytes-positive and HR-negative were independent predictive factors of pCR in primary HER2-positive breast cancer treated with trastuzumab-based NAC.	nac	181-184	erb-b2 receptor tyrosine kinase 2	Homo sapiens	122-126
26639425-6	2016	Moreover, the expression of GluR1 in the IL and NAc remarkably increased after treatment with PEPA during the reinstatement.	nac	48-51	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	28-33
26549752-7	2016	Pretreatment with NAC significantly reduced ROS level and p53 expression in BRL cells.	nac	18-21	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	58-61
26657653-3	2016	METHODS: We identified 287 patients with primary HER2-positive breast cancers given neoadjuvant chemotherapy (NAC) between 2002 and 2011.	nac	110-113	erb-b2 receptor tyrosine kinase 2	Homo sapiens	49-53
25916979-3	2016	This study attempted to investigate the value of ALDH1 as a predictive marker of chemosensitivity and its prognostic value in cervical cancer patients treated with NAC.	nac	164-167	aldehyde dehydrogenase 1 family member A1	Homo sapiens	49-54
25916979-4	2016	METHODS: Immunohistochemistry was used to evaluate ALDH1 expression in matched pre- and post-NAC tumor samples from 52 patients with cervical cancer.	nac	93-96	aldehyde dehydrogenase 1 family member A1	Homo sapiens	51-56
25916979-6	2016	RESULTS: Fourteen patients (26.9 %) had ALDH1-positive tumors pre-NAC, and ALDH1 expression pre-NAC was significantly associated with a low clinical chemotherapy response rate and clinical non-response.	nac	96-99	aldehyde dehydrogenase 1 family member A1	Homo sapiens	75-80
25916979-8	2016	Multivariate analysis revealed that ALDH1 expression post-NAC was an independent prognostic factor for OS (hazard ratio 3.513; p = 0.033).	nac	58-61	aldehyde dehydrogenase 1 family member A1	Homo sapiens	36-41
25916979-9	2016	Moreover, we observed that ALDH1 expression was increased after NAC in 18 patients (36.7 %).	nac	64-67	aldehyde dehydrogenase 1 family member A1	Homo sapiens	27-32
25916979-10	2016	Increased levels of ALDH1 expression after NAC predicted poor DFS and OS (p = 0.013 and p = 0.08, respectively).	nac	43-46	aldehyde dehydrogenase 1 family member A1	Homo sapiens	20-25
25916979-11	2016	CONCLUSIONS: Our findings suggest that ALDH1 expression pre-NAC may be a predictive marker for response to NAC, and ALDH1 expression post-NAC could be a prognostic marker for cervical cancer.	nac	60-63	aldehyde dehydrogenase 1 family member A1	Homo sapiens	39-44
25916979-11	2016	CONCLUSIONS: Our findings suggest that ALDH1 expression pre-NAC may be a predictive marker for response to NAC, and ALDH1 expression post-NAC could be a prognostic marker for cervical cancer.	nac	107-110	aldehyde dehydrogenase 1 family member A1	Homo sapiens	39-44
25916979-11	2016	CONCLUSIONS: Our findings suggest that ALDH1 expression pre-NAC may be a predictive marker for response to NAC, and ALDH1 expression post-NAC could be a prognostic marker for cervical cancer.	nac	107-110	aldehyde dehydrogenase 1 family member A1	Homo sapiens	39-44
25980321-11	2016	However, despite the high number to treating in order to achieve BCS, a small subset of ILC patients, especially cT2 and cT3 patients, still may benefit from NAC.	nac	158-161	solute carrier family 6 member 10, pseudogene	Homo sapiens	113-116
25980321-11	2016	However, despite the high number to treating in order to achieve BCS, a small subset of ILC patients, especially cT2 and cT3 patients, still may benefit from NAC.	nac	158-161	cancer antigen 1	Homo sapiens	121-124
26152274-6	2016	For primary breast tumors, CK19 mRNA expression showed a significant reduction after NAC (P = 0.040).	nac	85-88	keratin 19	Homo sapiens	27-31
26152274-8	2016	The findings obtained with CK19 mRNA ISH suggest that most SLN micromets cannot be detected by OSNA due to the reduced expression of CK19 mRNA induced by NAC.	nac	154-157	keratin 19	Homo sapiens	27-31
26152274-8	2016	The findings obtained with CK19 mRNA ISH suggest that most SLN micromets cannot be detected by OSNA due to the reduced expression of CK19 mRNA induced by NAC.	nac	154-157	sarcolipin	Homo sapiens	59-62
26152274-8	2016	The findings obtained with CK19 mRNA ISH suggest that most SLN micromets cannot be detected by OSNA due to the reduced expression of CK19 mRNA induced by NAC.	nac	154-157	keratin 19	Homo sapiens	133-137
26757422-2	2016	In this study, we investigated the association between chemotherapy sensitivity and AR expression in patients treated with neoadjuvant chemotherapy (NAC) using standardised chemotherapy criteria and regimens.	nac	149-152	androgen receptor	Homo sapiens	84-86
26757422-8	2016	CONCLUSIONS: Androgen receptor expressions may be useful as biomarkers to predict treatment responses to NAC in TNBC.	nac	105-108	androgen receptor	Homo sapiens	13-30
26757422-9	2016	Moreover, induction of a change in subtype to the AR-negative phenotype was observed after NAC.	nac	91-94	androgen receptor	Homo sapiens	50-52
27777963-6	2016	NAC significantly reduced CD4+, FOXP3+, CTLA-4+ (stromal) (concurrently blood FOXP3+, CTLA-4+ Tregs), and PD-1+ T cells; no reduction was seen with CD8+ and CTLA-4+ (intratumoural) T cells.	nac	0-3	cytotoxic T-lymphocyte protein 4	Sus scrofa	40-46
27777963-6	2016	NAC significantly reduced CD4+, FOXP3+, CTLA-4+ (stromal) (concurrently blood FOXP3+, CTLA-4+ Tregs), and PD-1+ T cells; no reduction was seen with CD8+ and CTLA-4+ (intratumoural) T cells.	nac	0-3	CD4 molecule	Sus scrofa	26-29
27777963-6	2016	NAC significantly reduced CD4+, FOXP3+, CTLA-4+ (stromal) (concurrently blood FOXP3+, CTLA-4+ Tregs), and PD-1+ T cells; no reduction was seen with CD8+ and CTLA-4+ (intratumoural) T cells.	nac	0-3	forkhead box P3	Sus scrofa	78-83
27777963-6	2016	NAC significantly reduced CD4+, FOXP3+, CTLA-4+ (stromal) (concurrently blood FOXP3+, CTLA-4+ Tregs), and PD-1+ T cells; no reduction was seen with CD8+ and CTLA-4+ (intratumoural) T cells.	nac	0-3	forkhead box P3	Sus scrofa	32-37
27777963-6	2016	NAC significantly reduced CD4+, FOXP3+, CTLA-4+ (stromal) (concurrently blood FOXP3+, CTLA-4+ Tregs), and PD-1+ T cells; no reduction was seen with CD8+ and CTLA-4+ (intratumoural) T cells.	nac	0-3	cytotoxic T-lymphocyte protein 4	Sus scrofa	86-92
27777963-6	2016	NAC significantly reduced CD4+, FOXP3+, CTLA-4+ (stromal) (concurrently blood FOXP3+, CTLA-4+ Tregs), and PD-1+ T cells; no reduction was seen with CD8+ and CTLA-4+ (intratumoural) T cells.	nac	0-3	cytotoxic T-lymphocyte protein 4	Sus scrofa	86-92
27777963-7	2016	High post-NAC tumour levels of FOXP3+ T cells, IL-10, and IL-17 were associated with a failed pCR.	nac	10-13	forkhead box P3	Homo sapiens	31-36
27777963-7	2016	High post-NAC tumour levels of FOXP3+ T cells, IL-10, and IL-17 were associated with a failed pCR.	nac	10-13	interleukin 17A	Homo sapiens	58-63
25927246-8	2016	Interestingly, TLCK massively augmented CD95-induced MMP which could be abrogated by NAC.	nac	85-88	Fas cell surface death receptor	Homo sapiens	40-44
26384297-7	2015	We demonstrated that there was a significant decrease in expression of PR (P = 0.013) and Ki-67 (P = 0.000) in post-NAC specimens compared to pre-NAC core biopsies.	nac	116-119	progesterone receptor	Homo sapiens	71-73
30444331-1	2016	This review summarizes the clinical trials of the relationship of gene expression and protein ABC-transporters in breast cancer with the response to neoadjuvant chemotherapy (NAC) and survival of patients.	nac	175-178	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	94-97
30444331-5	2016	The own results showed that 5-year distant metastasis-free survival was 73-78% and good response to NAC in patients with a decrease in ABC- expression.	nac	100-103	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	135-138
26585822-2	2015	The PI3K/Akt pathway plays a role in chemoresistance to platinum-based neoadjuvant chemotherapy (NAC).	nac	97-100	AKT serine/threonine kinase 1	Homo sapiens	9-12
26585822-3	2015	The objective of this study was to evaluate the association between genetic polymorphisms in the PI3K/Akt pathway and chemotherapeutic outcomes following platinum-based NAC in Northwestern Chinese Han patients with squamous cervical cancer (SCC).	nac	169-172	AKT serine/threonine kinase 1	Homo sapiens	102-105
26585822-9	2015	Furthermore, NAC non-responders had a higher frequency of the rs10416620 and rs62107593 G alleles in the Akt2 gene (rs10416620 and rs62107593: uncorrected P=0.037).	nac	13-16	AKT serine/threonine kinase 2	Homo sapiens	105-109
26585822-11	2015	Moreover, rs2498786 (uncorrected P=0.036) and the GGCC haplotype of polymorphisms in Akt1 showed a high risk for non-response to NAC (uncorrected P=0.018).	nac	129-132	AKT serine/threonine kinase 1	Homo sapiens	85-89
26210778-1	2015	OBJECTIVES: To investigate whether patients with germline BRCA1/2 mutations who received neoadjuvant chemotherapy (NAC) for advanced-stage Mullerian cancer (MC) have an improved outcome compared to patients who did not undergo genetic testing.	nac	115-118	BRCA1 DNA repair associated	Homo sapiens	58-65
26210778-10	2015	CONCLUSIONS: Patients with germline BRCA mutations had improved outcomes with NAC compared to patients with unknown BRCA status.	nac	78-81	BRCA1 DNA repair associated	Homo sapiens	36-40
26213096-7	2015	Results showed that NAC cultivation caused an increase of CD25 and PD-1 expressing cells in the CD4 positive fraction, enhancement of NK cell cytotoxicity, production of interferon-y (IFNgamma), and slight enhancement of regulatory T cell function.	nac	20-23	interleukin 2 receptor subunit alpha	Sus scrofa	58-62
26213096-7	2015	Results showed that NAC cultivation caused an increase of CD25 and PD-1 expressing cells in the CD4 positive fraction, enhancement of NK cell cytotoxicity, production of interferon-y (IFNgamma), and slight enhancement of regulatory T cell function.	nac	20-23	CD4 molecule	Sus scrofa	96-99
26213096-7	2015	Results showed that NAC cultivation caused an increase of CD25 and PD-1 expressing cells in the CD4 positive fraction, enhancement of NK cell cytotoxicity, production of interferon-y (IFNgamma), and slight enhancement of regulatory T cell function.	nac	20-23	interferon gamma	Sus scrofa	184-192
26384297-7	2015	We demonstrated that there was a significant decrease in expression of PR (P = 0.013) and Ki-67 (P = 0.000) in post-NAC specimens compared to pre-NAC core biopsies.	nac	146-149	progesterone receptor	Homo sapiens	71-73
26384297-9	2015	Finally we studied cases with HER2 status changes after NAC treatments in detail and emphasized the nature of tumor heterogeneity.	nac	56-59	erb-b2 receptor tyrosine kinase 2	Homo sapiens	30-34
26805275-6	2015	Chemotherapy with trastuzumab appears to be an effective NAC treatment for HER2-positive, advanced gastric cancer.	nac	57-60	erb-b2 receptor tyrosine kinase 2	Homo sapiens	75-79
26498019-12	2015	A 30 % threshold for stromal TILs optimally identified response to trastuzumab-based NAC in HER2-positive breast cancer; its predictive and prognostic value was also validated in our study.	nac	85-88	erb-b2 receptor tyrosine kinase 2	Homo sapiens	92-96
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	interleukin 1 beta	Homo sapiens	83-100
26407000-8	2015	Three NAC family proteins, ANAC019/055/072, downstream from MYC2/3/4 proteins, could also directly promote the expression of a similar set of CCGs (NYE1/SGR1, NYE2/SGR2 and NYC1) during Chl degradation.	nac	6-9	NAC domain containing protein 19	Arabidopsis thaliana	27-34
26407000-8	2015	Three NAC family proteins, ANAC019/055/072, downstream from MYC2/3/4 proteins, could also directly promote the expression of a similar set of CCGs (NYE1/SGR1, NYE2/SGR2 and NYC1) during Chl degradation.	nac	6-9	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	60-68
26407000-8	2015	Three NAC family proteins, ANAC019/055/072, downstream from MYC2/3/4 proteins, could also directly promote the expression of a similar set of CCGs (NYE1/SGR1, NYE2/SGR2 and NYC1) during Chl degradation.	nac	6-9	non-yellowing 1	Arabidopsis thaliana	148-157
26407000-8	2015	Three NAC family proteins, ANAC019/055/072, downstream from MYC2/3/4 proteins, could also directly promote the expression of a similar set of CCGs (NYE1/SGR1, NYE2/SGR2 and NYC1) during Chl degradation.	nac	6-9	STAY-GREEN-like protein	Arabidopsis thaliana	159-163
26407000-8	2015	Three NAC family proteins, ANAC019/055/072, downstream from MYC2/3/4 proteins, could also directly promote the expression of a similar set of CCGs (NYE1/SGR1, NYE2/SGR2 and NYC1) during Chl degradation.	nac	6-9	shoot gravitropism 2 (SGR2)	Arabidopsis thaliana	164-168
26407000-8	2015	Three NAC family proteins, ANAC019/055/072, downstream from MYC2/3/4 proteins, could also directly promote the expression of a similar set of CCGs (NYE1/SGR1, NYE2/SGR2 and NYC1) during Chl degradation.	nac	6-9	NAD(P)-binding Rossmann-fold superfamily protein	Arabidopsis thaliana	173-177
26482555-8	2015	UGT1A1 genotyping revealed that patients with UGT1A1 polymorphisms exhibited significantly higher response rates to NAC than those with the wild-type (79.5 vs. 49.5 %, respectively, p &lt; 0.05).	nac	116-119	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
26482555-8	2015	UGT1A1 genotyping revealed that patients with UGT1A1 polymorphisms exhibited significantly higher response rates to NAC than those with the wild-type (79.5 vs. 49.5 %, respectively, p &lt; 0.05).	nac	116-119	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	46-52
26482555-9	2015	CONCLUSIONS: These results indicate that GMP scores of cancerous tissue combined with UGT1A1 genotyping of blood samples may serve as highly potent markers for predicting the efficacy of NAC for individual SCC patients.	nac	187-190	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	86-92
26336821-10	2015	Hence, the DeltaSUV after two cycles of neoadjuvant therapy could predict pCR in HER2-negative patients treated with NAC alone, but not in HER2-positive patients treated with NAC plus trastuzumab.	nac	117-120	erb-b2 receptor tyrosine kinase 2	Homo sapiens	81-85
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	interleukin 1 beta	Homo sapiens	102-110
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	interleukin 4	Homo sapiens	113-117
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	interleukin 6	Homo sapiens	119-123
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	interleukin 17F	Homo sapiens	125-131
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	interleukin 21	Homo sapiens	133-138
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	interleukin 23 subunit alpha	Homo sapiens	140-145
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	interleukin 25	Homo sapiens	147-152
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	interleukin 31	Homo sapiens	154-159
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	interferon gamma	Homo sapiens	161-177
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	interferon gamma	Homo sapiens	179-187
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	CD40 ligand	Homo sapiens	190-201
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	CD40 ligand	Homo sapiens	203-208
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	tumor necrosis factor	Homo sapiens	211-238
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	tumor necrosis factor	Homo sapiens	240-248
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	C-X-C motif chemokine ligand 1	Homo sapiens	251-256
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	C-X-C motif chemokine ligand 2	Homo sapiens	258-263
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	C-X-C motif chemokine ligand 5	Homo sapiens	265-270
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	C-C motif chemokine ligand 3	Homo sapiens	272-276
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	C-C motif chemokine ligand 7	Homo sapiens	278-282
26313265-7	2015	The WF harvested from patients underwent NAC showed significant higher profiles of interleukin-1beta (IL-1beta), IL-4, IL-6, IL-17F, IL-21, IL-23, IL-25, IL-31, Interferon gamma (IFNgamma), CD40 ligand (CD40L), tumor necrosis factor alpha (TNFalpha), CXCL1, CXCL2, CXCL5, CCL3, CCL7 and CCL20.	nac	41-44	C-C motif chemokine ligand 20	Homo sapiens	287-292
26440076-4	2015	A complete set of 148 nonredundant NAC genes (ZmNAC1-ZmNAC148) were identifiedin the maize genome using Blast search tools, and divided into 12 groups (a-l) based on phylogeny.	nac	35-38	NAC domain-containing protein 2	Zea mays	46-52
26345461-12	2015	CONCLUSIONS: High-HG, low-ER, low-PgR, high-Ki67, and low-p27(Kip1) were identified as predictive factors of pCR in NAC with trastuzumab, while pCR and negative nodes were predictive of better survivals.	nac	116-119	progesterone receptor	Homo sapiens	34-37
26345461-12	2015	CONCLUSIONS: High-HG, low-ER, low-PgR, high-Ki67, and low-p27(Kip1) were identified as predictive factors of pCR in NAC with trastuzumab, while pCR and negative nodes were predictive of better survivals.	nac	116-119	zinc ribbon domain containing 2	Homo sapiens	58-61
26345461-12	2015	CONCLUSIONS: High-HG, low-ER, low-PgR, high-Ki67, and low-p27(Kip1) were identified as predictive factors of pCR in NAC with trastuzumab, while pCR and negative nodes were predictive of better survivals.	nac	116-119	cyclin dependent kinase inhibitor 1B	Homo sapiens	62-66
26341640-14	2015	CONCLUSIONS: This is the first study to demonstrate that high CD8(+) TIL and a high CD8/FOXP3 ratio in residual tumors and increment of these parameters following NAC and accurately predict improved prognosis in TNBC patients with non-pathological complete response following NAC.	nac	163-166	CD8a molecule	Homo sapiens	84-87
26341640-14	2015	CONCLUSIONS: This is the first study to demonstrate that high CD8(+) TIL and a high CD8/FOXP3 ratio in residual tumors and increment of these parameters following NAC and accurately predict improved prognosis in TNBC patients with non-pathological complete response following NAC.	nac	276-279	CD8a molecule	Homo sapiens	62-65
26341640-14	2015	CONCLUSIONS: This is the first study to demonstrate that high CD8(+) TIL and a high CD8/FOXP3 ratio in residual tumors and increment of these parameters following NAC and accurately predict improved prognosis in TNBC patients with non-pathological complete response following NAC.	nac	276-279	CD8a molecule	Homo sapiens	84-87
26202564-2	2015	Furthermore, neoadjuvant chemotherapy (NAC) with dual HER2 agents demonstrated improved pathological complete response (pCR) rates.	nac	39-42	erb-b2 receptor tyrosine kinase 2	Homo sapiens	54-58
26202564-3	2015	With these data, and with US FDA approval in September 2013 of pertuzumab in the neoadjuvant setting, we hypothesized that the use of NAC for early-stage HER2-positive patients is increasing.	nac	134-137	erb-b2 receptor tyrosine kinase 2	Homo sapiens	154-158
26202564-15	2015	CONCLUSIONS: NAC for HER2-positive breast cancer patients is increasing.	nac	13-16	erb-b2 receptor tyrosine kinase 2	Homo sapiens	21-25
26345596-1	2015	OBJECTIVES: We investigated the impact of neoadjuvant chemotherapy (NAC) on axillary disease burden in clinically node-negative (cN0) HER-2 positive breast cancer patients.	nac	68-71	erb-b2 receptor tyrosine kinase 2	Homo sapiens	134-139
26345596-10	2015	CONCLUSION: NAC in cN0 HER-2 positive breast cancers reduces the rate of pathologic node-positive disease at operation and nodal disease burden and may decrease the need for axillary node dissection.	nac	12-15	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-28
26394326-11	2015	However, new assessment methods are required to effectively evaluate the pathologic response of HR+/HER2+ and HR-/HER2+ tumors to anthracycline with/without taxane-based NAC.	nac	170-173	erb-b2 receptor tyrosine kinase 2	Homo sapiens	100-104
26394326-11	2015	However, new assessment methods are required to effectively evaluate the pathologic response of HR+/HER2+ and HR-/HER2+ tumors to anthracycline with/without taxane-based NAC.	nac	170-173	erb-b2 receptor tyrosine kinase 2	Homo sapiens	114-118
26362310-3	2015	METHODS: MRP1 and Notch1 were investigated in 29 patients treated with neoadjuvant chemotherapy (NAC) for breast cancer, using immunohistochemistry on matched biopsy (pre-NAC) and surgical samples (post-NAC).	nac	97-100	ATP binding cassette subfamily C member 1	Homo sapiens	9-13
26052094-8	2015	In addition, MPCP155 was found to be useful for prognosis prediction for NAC-treated patients with ER+/HER2- tumors.	nac	73-76	estrogen receptor 1	Homo sapiens	99-101
26277523-1	2015	OBJECTIVE: To investigate whether apollon immunoexpression in breast cancer tissues helps to predict pathological complete response (pCR) after neoadjuvant chemotherapy (NAC).	nac	170-173	baculoviral IAP repeat containing 6	Homo sapiens	34-41
25580585-7	2015	After the comparison between two different subtypes, the pre-NAC ADC value of the triple-negative and HER2-enriched subtypes were significantly higher than Luminal A (P &lt; 0.001 and P &lt; 0.001) and Luminal B subtype (P &lt; 0.001 and P = 0.009), and the post-NAC ADC of triple-negative subtype was significantly higher than the others (P &lt; 0.001).	nac	61-64	erb-b2 receptor tyrosine kinase 2	Homo sapiens	102-106
25580585-7	2015	After the comparison between two different subtypes, the pre-NAC ADC value of the triple-negative and HER2-enriched subtypes were significantly higher than Luminal A (P &lt; 0.001 and P &lt; 0.001) and Luminal B subtype (P &lt; 0.001 and P = 0.009), and the post-NAC ADC of triple-negative subtype was significantly higher than the others (P &lt; 0.001).	nac	263-266	erb-b2 receptor tyrosine kinase 2	Homo sapiens	102-106
26317631-1	2015	NAC [no apical meristem (NAM), Arabidopsis transcription activation factor [ATAF1/2] and cup-shaped cotyledon (CUC2)] proteins is one of the largest groups of plant specific transcription factors and plays a crucial role in plant growth, development, and adaption to the environment.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	25-28
26317631-1	2015	NAC [no apical meristem (NAM), Arabidopsis transcription activation factor [ATAF1/2] and cup-shaped cotyledon (CUC2)] proteins is one of the largest groups of plant specific transcription factors and plays a crucial role in plant growth, development, and adaption to the environment.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	76-83
26317631-1	2015	NAC [no apical meristem (NAM), Arabidopsis transcription activation factor [ATAF1/2] and cup-shaped cotyledon (CUC2)] proteins is one of the largest groups of plant specific transcription factors and plays a crucial role in plant growth, development, and adaption to the environment.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	111-115
26317631-6	2015	Conserved motif analysis revealed that all of the identified MeNACs had the conserved NAC domain and/or NAM domain.	nac	63-66	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	104-107
26297025-2	2015	NAC (NAM, ATAF and CUC) transcription factors are known to be crucial in plants tolerance response to abiotic stresses, such as drought and salinity.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	5-8
25969370-13	2015	CONCLUSION: In this series, patients who received NAC/N-CRT for cT3 and/or cN+ PUC appeared to demonstrate improved survival compared with those who underwent upfront surgery with or without ACH.	nac	50-53	cancer antigen 1	Homo sapiens	64-67
26041506-13	2015	Moreover, atorvastatin other than DPI, NAC, SB203580 and Nox1 siRNA transfection blocked Hcy-induced p38 MAPK phosphorylation, which was also reversed by the mevalonate.	nac	39-42	mitogen activated protein kinase 14	Rattus norvegicus	101-104
25991739-4	2015	GhNAP has the typical NAC structure and a conserved novel subdomain in its divergent transcription activation region (TAR).	nac	22-25	NAC transcription factor 29-like	Gossypium hirsutum	0-5
26277523-8	2015	Negative expressions of apollon, ER and PR were all associated with a higher pCR rate after NAC.	nac	92-95	baculoviral IAP repeat containing 6	Homo sapiens	24-31
26277523-8	2015	Negative expressions of apollon, ER and PR were all associated with a higher pCR rate after NAC.	nac	92-95	estrogen receptor 1	Homo sapiens	33-35
26112249-7	2015	Finally, the pretreatment of antioxidant NAC ameliorated Fas, FADD and caspase 8/3 expressions, which illustrated that TCBQ-induced apoptotic signaling is ROS dependent.	nac	41-44	caspase 8	Rattus norvegicus	71-80
26230923-10	2015	The combination of GDPD3 and SPRED1 resulted in a multivariate classification tree that was significantly associated with NAC response status (Goodman-Kruskal gamma = 0.85 p&lt;0.0001) in our independent NAC treated MIBC cohort.	nac	122-125	glycerophosphodiester phosphodiesterase domain containing 3	Homo sapiens	19-24
26230923-10	2015	The combination of GDPD3 and SPRED1 resulted in a multivariate classification tree that was significantly associated with NAC response status (Goodman-Kruskal gamma = 0.85 p&lt;0.0001) in our independent NAC treated MIBC cohort.	nac	122-125	sprouty related EVH1 domain containing 1	Homo sapiens	29-35
26230923-10	2015	The combination of GDPD3 and SPRED1 resulted in a multivariate classification tree that was significantly associated with NAC response status (Goodman-Kruskal gamma = 0.85 p&lt;0.0001) in our independent NAC treated MIBC cohort.	nac	204-207	glycerophosphodiester phosphodiesterase domain containing 3	Homo sapiens	19-24
26230923-10	2015	The combination of GDPD3 and SPRED1 resulted in a multivariate classification tree that was significantly associated with NAC response status (Goodman-Kruskal gamma = 0.85 p&lt;0.0001) in our independent NAC treated MIBC cohort.	nac	204-207	sprouty related EVH1 domain containing 1	Homo sapiens	29-35
26218222-4	2015	It was previously reported that EIN3, miR164, and a NAC (NAM, ATAF, and CUC) transcription factor ORE1/NAC2 constitute a regulatory network mediating leaf senescence.	nac	52-55	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	57-60
26218222-4	2015	It was previously reported that EIN3, miR164, and a NAC (NAM, ATAF, and CUC) transcription factor ORE1/NAC2 constitute a regulatory network mediating leaf senescence.	nac	52-55	NAC domain containing protein 6	Arabidopsis thaliana	98-102
26218222-4	2015	It was previously reported that EIN3, miR164, and a NAC (NAM, ATAF, and CUC) transcription factor ORE1/NAC2 constitute a regulatory network mediating leaf senescence.	nac	52-55	NAC domain containing protein 2	Arabidopsis thaliana	103-107
26328259-3	2015	The aim of this study is to assess the predictive impact of organic cation transporter 2 (OCT2) expression on response to neoadjuvant chemotherapy (NAC) in gastric cancer.	nac	148-151	solute carrier family 22 member 2	Homo sapiens	60-88
26328259-3	2015	The aim of this study is to assess the predictive impact of organic cation transporter 2 (OCT2) expression on response to neoadjuvant chemotherapy (NAC) in gastric cancer.	nac	148-151	solute carrier family 22 member 2	Homo sapiens	90-94
26328259-11	2015	Taken together, our results suggest that OCT2(high) may represent a potential predictor of response to NAC with S-1/cisplatin in gastric cancer.	nac	103-106	solute carrier family 22 member 2	Homo sapiens	41-51
26063926-4	2015	Furthermore, upregulation of DNA methyltransferase 3a and 3b and global DNA hypomethylation were observed in the nucleus accumbens core (NAc), but not in the medial prefrontal cortex (mPFC), of cocaine-pretreated rats.	nac	137-140	DNA methyltransferase 3 alpha	Rattus norvegicus	29-60
26063926-6	2015	When compared with vehicle-pretreated rats, the immediate early gene c-Fos (a marker of neuronal activation) was upregulated in the NAc and mPFC of cocaine-pretreated rats after cocaine-primed reinstatement, and chronic MET treatment blocked its induction in both regions.	nac	132-135	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	69-74
26063926-7	2015	Cocaine-induced c-Fos expression in the NAc was associated with reduced methylation at CpG dinucleotides in the c-Fos gene promoter, effects reversed by MET treatment.	nac	40-43	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	16-21
26063926-7	2015	Cocaine-induced c-Fos expression in the NAc was associated with reduced methylation at CpG dinucleotides in the c-Fos gene promoter, effects reversed by MET treatment.	nac	40-43	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	112-117
26006068-10	2015	Higher expression of cytotoxic molecules, T cell receptor signaling pathway components, Th1-related cytokines, and B cell markers is correlated with pCR and survival in TNBC patients treated with NAC.	nac	196-199	negative elongation factor complex member C/D	Homo sapiens	88-91
25523085-2	2015	MusaVND1 is an ortholog of Arabidopsis VND1 and contains the highly conserved NAC domain.	nac	78-81	vascular related NAC-domain protein 1	Arabidopsis thaliana	4-8
25510376-4	2015	Three cycles of gemcitabine and cisplatin was the most common NAC regimen, with 93% and 67% respondents giving it for downstaging of cN1- and cN2- and 3-positive patients, respectively.	nac	62-65	5'-nucleotidase, cytosolic IA	Homo sapiens	133-136
25510376-4	2015	Three cycles of gemcitabine and cisplatin was the most common NAC regimen, with 93% and 67% respondents giving it for downstaging of cN1- and cN2- and 3-positive patients, respectively.	nac	62-65	carnosine dipeptidase 2	Homo sapiens	142-145
25883123-1	2015	UNLABELLED: This study investigated whether (18)F-FDG PET/CT performed at baseline and during neoadjuvant chemotherapy (NAC) was able to early depict estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-) breast cancer patients with poor clinical outcome.	nac	120-123	erb-b2 receptor tyrosine kinase 2	Homo sapiens	183-217
25883123-1	2015	UNLABELLED: This study investigated whether (18)F-FDG PET/CT performed at baseline and during neoadjuvant chemotherapy (NAC) was able to early depict estrogen receptor-positive/human epidermal growth factor receptor 2-negative (ER+/HER2-) breast cancer patients with poor clinical outcome.	nac	120-123	erb-b2 receptor tyrosine kinase 2	Homo sapiens	232-236
25883123-13	2015	CONCLUSION: Baseline tumor (18)F-FDG uptake and modifications after 2 cycles of NAC are prognostic of outcome in patients with ER+/HER2- breast cancer.	nac	80-83	erb-b2 receptor tyrosine kinase 2	Homo sapiens	131-135
25119188-6	2015	SAHA induced generation of reactive oxygen species (ROS), and the cleavage of HSP90 was blocked by a ROS scavenger N-acetylcystein (NAC).	nac	132-135	heat shock protein 90 alpha family class A member 1	Homo sapiens	78-83
25572919-9	2015	Taken together, the results suggested a regulatory network model mediated by ANAC069, under abiotic stress conditions, ATDOF5.8 regulates the expression of ANAC069, and the activated ANAC069 binds to NAC recognition sequences or other motifs to regulate the expression of genes containing these motifs in their promoters.	nac	78-81	NAC domain containing protein 69	Arabidopsis thaliana	156-163
25572919-9	2015	Taken together, the results suggested a regulatory network model mediated by ANAC069, under abiotic stress conditions, ATDOF5.8 regulates the expression of ANAC069, and the activated ANAC069 binds to NAC recognition sequences or other motifs to regulate the expression of genes containing these motifs in their promoters.	nac	78-81	NAC domain containing protein 69	Arabidopsis thaliana	156-163
25078559-4	2015	Two miRNAs, miR-34a and miR-122, that were significantly increased after NAC, were measured in tumor tissue before and after chemotherapy in 7 patients with pathological partial response (pPR) to NAC.	nac	73-76	microRNA 34a	Homo sapiens	12-19
25078559-4	2015	Two miRNAs, miR-34a and miR-122, that were significantly increased after NAC, were measured in tumor tissue before and after chemotherapy in 7 patients with pathological partial response (pPR) to NAC.	nac	73-76	microRNA 122	Homo sapiens	24-31
25078559-8	2015	Furthermore, miR-34a level was elevated in the remaining tumor tissue after NAC treatment.	nac	76-79	microRNA 34a	Homo sapiens	13-20
25078559-9	2015	Studying the kinetics of circulating miR-34a and miR-122 expression during NAC revealed that their levels were especially increased after anthracycline-based chemotherapy.	nac	75-78	microRNA 34a	Homo sapiens	37-44
25078559-9	2015	Studying the kinetics of circulating miR-34a and miR-122 expression during NAC revealed that their levels were especially increased after anthracycline-based chemotherapy.	nac	75-78	microRNA 122	Homo sapiens	49-56
25550184-9	2015	Interestingly, low DCN expression was observed in five (83%) of six cases with complete responses to S-1 NAC, and in one (10%) case of 10 cases with stable/progressive disease, indicating that S-1 chemosensitivity is dramatically effective in oral cancer patients with low DCN expression compared with high DCN expression.	nac	105-108	decorin	Homo sapiens	19-22
25550184-10	2015	Our findings suggest that DCN is a key regulator for chemoresistant mechanisms, and is a predictive immunomarker of the response to S-1 NAC and patient prognosis.	nac	136-139	decorin	Homo sapiens	26-29
25422910-8	2015	CONCLUSIONS: Our present study showed low FOXA1 expression to be associated with a good response to NAC in luminal HER2-negative breast cancer.	nac	100-103	forkhead box A1	Homo sapiens	42-47
25422910-8	2015	CONCLUSIONS: Our present study showed low FOXA1 expression to be associated with a good response to NAC in luminal HER2-negative breast cancer.	nac	100-103	erb-b2 receptor tyrosine kinase 2	Homo sapiens	115-119
26137266-8	2015	Immunostaining for the platelet surface marker CD42b (glycoprotein Ib), revealed more platelets in the liver in the NAC compared to the control group, particularly in the centrilobular zone III, adjacent to the hepatic central vein and in contact with hepatocytes (P&lt;0.01).	nac	116-119	glycoprotein Ib platelet subunit alpha	Homo sapiens	47-52
25814145-12	2015	A multivariate classification tree model demonstrated 60 years of age or younger and clinical stage cT2 as significant of NAC response (P&lt; 0.05).	nac	122-125	solute carrier family 6 member 10, pseudogene	Homo sapiens	100-103
25832431-13	2015	Moreover, physalin B treatment dose-dependently increased mito-ROS production in the cells, whereas the ROS scavenger NAC could reverse physalin B-induced effects, including incomplete autophagic response, accumulation of ubiquitinated proteins, changes of microtubules and F-actin, activation of p38, ERK and JNK, as well as cell death and apoptosis.	nac	118-121	mitogen-activated protein kinase 14	Homo sapiens	297-300
25832431-13	2015	Moreover, physalin B treatment dose-dependently increased mito-ROS production in the cells, whereas the ROS scavenger NAC could reverse physalin B-induced effects, including incomplete autophagic response, accumulation of ubiquitinated proteins, changes of microtubules and F-actin, activation of p38, ERK and JNK, as well as cell death and apoptosis.	nac	118-121	mitogen-activated protein kinase 1	Homo sapiens	302-305
25832431-13	2015	Moreover, physalin B treatment dose-dependently increased mito-ROS production in the cells, whereas the ROS scavenger NAC could reverse physalin B-induced effects, including incomplete autophagic response, accumulation of ubiquitinated proteins, changes of microtubules and F-actin, activation of p38, ERK and JNK, as well as cell death and apoptosis.	nac	118-121	mitogen-activated protein kinase 8	Homo sapiens	310-313
25732265-1	2015	BACKGROUND: Randomized clinical trials (RCT) that evaluated the addition of lapatinib to trastuzumab plus neoadjuvant chemotherapy (NAC) in patients with HER2-positive, operable breast cancer revealed a questionable improvement in pathologic complete response (pCR) rate.	nac	132-135	erb-b2 receptor tyrosine kinase 2	Homo sapiens	154-158
25702611-8	2015	We also detected strong interactions between TCP8 and SAR deficient 1 (SARD1), WRKY family transcription factor 28 (WRKY28), NAC (NAM/ATAF1,ATAF2/CUC2) family transcription factor 019 (NAC019), as well as among TCP8, TCP9 and TCP20, suggesting a complex coordinated regulatory mechanism underlying ICS1 expression.	nac	125-128	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	130-133
25702611-8	2015	We also detected strong interactions between TCP8 and SAR deficient 1 (SARD1), WRKY family transcription factor 28 (WRKY28), NAC (NAM/ATAF1,ATAF2/CUC2) family transcription factor 019 (NAC019), as well as among TCP8, TCP9 and TCP20, suggesting a complex coordinated regulatory mechanism underlying ICS1 expression.	nac	125-128	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	134-145
25834606-8	2015	Multivariate analysis showed that only p53 expression was independently associated with pCR to NAC (odds ratio, 3.961; p=0.003).	nac	95-98	tumor protein p53	Homo sapiens	39-42
25834606-11	2015	CONCLUSION: Expression of p53 was significantly associated with pCR after NAC in patients with TNBC, suggesting that this biomarker might be particularly valuable in identifying TNBC patients prone to have residual disease after NAC.	nac	74-77	tumor protein p53	Homo sapiens	26-29
25834606-11	2015	CONCLUSION: Expression of p53 was significantly associated with pCR after NAC in patients with TNBC, suggesting that this biomarker might be particularly valuable in identifying TNBC patients prone to have residual disease after NAC.	nac	229-232	tumor protein p53	Homo sapiens	26-29
24969049-6	2015	The NAC group had a significantly higher RFS in cT1/T2 cases, but showed similar survival in cT3 cases.	nac	4-7	cardiotrophin 1	Homo sapiens	48-51
25377909-8	2015	Ex vivo grass antigen-driven T-cell proliferative responses and the frequency of IL-4(+) CD4(+) T cells were significantly increased at 6 h after NAC when compared to the control day.	nac	146-149	interleukin 4	Homo sapiens	81-85
25377909-9	2015	CONCLUSION: Basophil, T-cell, and dendritic cell activation increased the frequency of allergen-driven IL-4(+) CD4(+) T cells, and T-cell proliferative responses are detectable in the periphery after NAC.	nac	200-203	interleukin 4	Homo sapiens	103-107
25449334-4	2015	In this study we examined whether some of the key molecules associated with the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR signaling pathways could have predictive and prognostic value for the NAC application.	nac	184-187	zinc fingers and homeoboxes 2	Homo sapiens	84-87
25449334-4	2015	In this study we examined whether some of the key molecules associated with the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR signaling pathways could have predictive and prognostic value for the NAC application.	nac	184-187	mitogen-activated protein kinase kinase 7	Homo sapiens	88-91
25449334-4	2015	In this study we examined whether some of the key molecules associated with the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR signaling pathways could have predictive and prognostic value for the NAC application.	nac	184-187	mitogen-activated protein kinase 1	Homo sapiens	92-95
25449334-4	2015	In this study we examined whether some of the key molecules associated with the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR signaling pathways could have predictive and prognostic value for the NAC application.	nac	184-187	AKT serine/threonine kinase 1	Homo sapiens	105-108
25449334-4	2015	In this study we examined whether some of the key molecules associated with the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR signaling pathways could have predictive and prognostic value for the NAC application.	nac	184-187	mechanistic target of rapamycin kinase	Homo sapiens	109-113
25449334-6	2015	LOH PTEN and low pERK expression is shown to be correlated with the longest survival of patients with SCC and ADC, respectively, who received NAC.	nac	142-145	phosphatase and tensin homolog	Homo sapiens	4-8
25449334-6	2015	LOH PTEN and low pERK expression is shown to be correlated with the longest survival of patients with SCC and ADC, respectively, who received NAC.	nac	142-145	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	17-21
25486578-6	2015	The experimental manipulation-induced increase in ERbeta levels was less widespread, being localized in PFC, the hippocampal CA2 area, MPOA and nAc-Sh.	nac	144-147	estrogen receptor 2	Rattus norvegicus	50-56
25119188-8	2015	Caspase 2, 3, 4, 6, 8, and 10 were activated by treatment with SAHA, and the activities were reduced by the pretreatment of NAC.	nac	124-127	caspase 2	Homo sapiens	0-9
26273337-5	2015	In the NAC group, the proportions of samples with changes in ER, PR, HER-2, and Ki-67 expression were 12.7%, 24.1%, 5.1%, and 38.0%, respectively; the figures in the control group were 2.4%, 4.9%, 2.4%, and 7.3%, respectively, which significantly differed in ER, PR, and Ki-67 (P &lt; 0.05), but not HER-2 (P &gt; 0.05).	nac	7-10	progesterone receptor	Homo sapiens	65-67
25751728-1	2015	Transcriptional regulation of secondary wall biosynthesis in Arabidopsis thaliana has been shown to be mediated by a group of secondary wall NAC master switches, including NST1, NST2, SND1 and VND1 to VND7.	nac	141-144	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	172-176
25751728-1	2015	Transcriptional regulation of secondary wall biosynthesis in Arabidopsis thaliana has been shown to be mediated by a group of secondary wall NAC master switches, including NST1, NST2, SND1 and VND1 to VND7.	nac	141-144	NAC domain protein 66	Arabidopsis thaliana	178-182
25751728-1	2015	Transcriptional regulation of secondary wall biosynthesis in Arabidopsis thaliana has been shown to be mediated by a group of secondary wall NAC master switches, including NST1, NST2, SND1 and VND1 to VND7.	nac	141-144	NAC domain containing protein 12	Arabidopsis thaliana	184-188
25751728-1	2015	Transcriptional regulation of secondary wall biosynthesis in Arabidopsis thaliana has been shown to be mediated by a group of secondary wall NAC master switches, including NST1, NST2, SND1 and VND1 to VND7.	nac	141-144	vascular related NAC-domain protein 1	Arabidopsis thaliana	193-197
25751728-1	2015	Transcriptional regulation of secondary wall biosynthesis in Arabidopsis thaliana has been shown to be mediated by a group of secondary wall NAC master switches, including NST1, NST2, SND1 and VND1 to VND7.	nac	141-144	vascular related NAC-domain protein 7	Arabidopsis thaliana	201-205
25469273-9	2015	SIRT1 expression was significantly higher in the NAC+R compared to the NAC+OP+R group (P&lt;0.001), as was p53 expression (P=0.001).	nac	49-52	sirtuin 1	Homo sapiens	0-5
25469273-9	2015	SIRT1 expression was significantly higher in the NAC+R compared to the NAC+OP+R group (P&lt;0.001), as was p53 expression (P=0.001).	nac	71-74	sirtuin 1	Homo sapiens	0-5
25469273-12	2015	Collectively, these results indicate that SIRT1 expression may predict the efficacy of NAC as a treatment for locally advanced uterine cervical cancer.	nac	87-90	sirtuin 1	Homo sapiens	42-47
26340415-5	2015	Transcription factors, such as NAC (NAM, ATAF1/2 and CUC2) and MYB domain proteins, serve as master regulators in SCW development.	nac	31-34	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	36-39
26340415-5	2015	Transcription factors, such as NAC (NAM, ATAF1/2 and CUC2) and MYB domain proteins, serve as master regulators in SCW development.	nac	31-34	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	41-48
26340415-5	2015	Transcription factors, such as NAC (NAM, ATAF1/2 and CUC2) and MYB domain proteins, serve as master regulators in SCW development.	nac	31-34	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	53-57
26273337-5	2015	In the NAC group, the proportions of samples with changes in ER, PR, HER-2, and Ki-67 expression were 12.7%, 24.1%, 5.1%, and 38.0%, respectively; the figures in the control group were 2.4%, 4.9%, 2.4%, and 7.3%, respectively, which significantly differed in ER, PR, and Ki-67 (P &lt; 0.05), but not HER-2 (P &gt; 0.05).	nac	7-10	erb-b2 receptor tyrosine kinase 2	Homo sapiens	69-74
26273337-5	2015	In the NAC group, the proportions of samples with changes in ER, PR, HER-2, and Ki-67 expression were 12.7%, 24.1%, 5.1%, and 38.0%, respectively; the figures in the control group were 2.4%, 4.9%, 2.4%, and 7.3%, respectively, which significantly differed in ER, PR, and Ki-67 (P &lt; 0.05), but not HER-2 (P &gt; 0.05).	nac	7-10	progesterone receptor	Homo sapiens	263-265
26273337-5	2015	In the NAC group, the proportions of samples with changes in ER, PR, HER-2, and Ki-67 expression were 12.7%, 24.1%, 5.1%, and 38.0%, respectively; the figures in the control group were 2.4%, 4.9%, 2.4%, and 7.3%, respectively, which significantly differed in ER, PR, and Ki-67 (P &lt; 0.05), but not HER-2 (P &gt; 0.05).	nac	7-10	erb-b2 receptor tyrosine kinase 2	Homo sapiens	300-305
26273337-8	2015	NAC can alter HR and Ki-67 status in breast adenocarcinoma patients.	nac	0-3	nuclear receptor subfamily 4 group A member 1	Homo sapiens	14-16
26273337-9	2015	NAC decreased PR(+) rate and Ki-67 expression.	nac	0-3	progesterone receptor	Homo sapiens	14-16
25395316-9	2014	Classical morphological parameters, such as lobular histotype and inflammation, confirmed their predictive value in response to NAC, particularly in the Luminal B/HER2- subgroup, which is a challenging breast cancer subtype from a therapeutic point of view.	nac	128-131	erb-b2 receptor tyrosine kinase 2	Homo sapiens	163-167
25487825-5	2014	Here, we identify the Saccharomyces cerevisiae outer membrane protein OM14 as a receptor for NAC.	nac	93-96	Om14p	Saccharomyces cerevisiae S288C	70-74
25487825-6	2014	OM14Delta mitochondria have significantly lower amounts of associated NAC and ribosomes, and ribosomes from NAC[Delta] cells have reduced levels of associated OM14.	nac	70-73	Om14p	Saccharomyces cerevisiae S288C	0-4
25487825-8	2014	Our results identify OM14 as the first mitochondrial receptor for ribosome-associated NAC and reveal its importance for import.	nac	86-89	Om14p	Saccharomyces cerevisiae S288C	21-25
25501357-11	2014	For TILs subset, higher levels of CD8+ and FOXP3+ T-lymphocytes in pre-treatment biopsy respectively predicted better pathological response to NAC (OR = 6.44, 95% CI: 2.52-16.46; OR = 2.94, 95% CI: 1.05-8.26).	nac	143-146	CD8a molecule	Homo sapiens	34-37
25501357-11	2014	For TILs subset, higher levels of CD8+ and FOXP3+ T-lymphocytes in pre-treatment biopsy respectively predicted better pathological response to NAC (OR = 6.44, 95% CI: 2.52-16.46; OR = 2.94, 95% CI: 1.05-8.26).	nac	143-146	forkhead box P3	Homo sapiens	43-48
25501357-12	2014	Only FOXP3+ lymphocytes in post-NAC breast tissue were a predictive marker for low pCR rate in univariate (OR = 0.41, 95% CI: 0.21-0.80) and multivariate (OR = 0.36, 95% CI: 0.13-0.95) analysis.	nac	32-35	forkhead box P3	Homo sapiens	5-10
25385240-8	2014	CONCLUSIONS: This study revealed that patients with HR altered from positive to negative after NAC still benefit from ET.	nac	95-98	nuclear receptor subfamily 4 group A member 1	Homo sapiens	52-54
25385240-9	2014	The HR status should be evaluated not only in specimens obtained during post-NAC surgery but also in specimens biopsied before NAC.	nac	77-80	nuclear receptor subfamily 4 group A member 1	Homo sapiens	4-6
25385240-9	2014	The HR status should be evaluated not only in specimens obtained during post-NAC surgery but also in specimens biopsied before NAC.	nac	127-130	nuclear receptor subfamily 4 group A member 1	Homo sapiens	4-6
25395319-7	2014	TNBCs with a high CD8+/FOXP3+ ratio and high Ki-67 had the highest pCR rate (70%) following NAC.	nac	92-95	CD8a molecule	Homo sapiens	18-21
25395319-10	2014	TNBCs with a high CD8+/FOXP3+ ratio were more sensitive to anthracycline and taxane-based chemotherapeutic regimens, and the CD8+/FOXP3+ ratio in conjunction with Ki-67 could predict pCR following NAC in TNBC.	nac	197-200	CD8a molecule	Homo sapiens	125-128
25364401-7	2014	The 2-DE analysis of the serum samples revealed that sorcin was upregulated in six out of 29 neoadjuvant chemotherapy (NAC)-sensitive patients and, in those who developed multidrug resistance, sorcin was upregulated in 15 out of 21 patients (P&lt;0.01).	nac	119-122	sorcin	Homo sapiens	53-59
25223808-1	2014	OBJECTIVE: To evaluate the different kinetic parameters of serum CA125 during neoadjuvant chemotherapy (NAC) to predict optimal interval debulking surgery (IDS).	nac	104-107	mucin 16, cell surface associated	Homo sapiens	65-70
25223808-8	2014	In multivariate analyses, the CA125 level after the 3rd NAC was an independent predictor for optimal cytoreduction (odds ratio: 0.98 [0.97-0.99], p=0.04).	nac	56-59	mucin 16, cell surface associated	Homo sapiens	30-35
25223808-12	2014	CONCLUSION: Our data indicate that for advanced ovarian cancer, a CA125 level less than 75 UI/ml after the 3rd NAC was an independent predictor factor for complete IDS.	nac	111-114	mucin 16, cell surface associated	Homo sapiens	66-71
25364442-8	2014	It was found that the expression of p-mTOR and p-4E-BP1 was downregulated following NAC.	nac	84-87	mechanistic target of rapamycin kinase	Homo sapiens	38-42
25364401-7	2014	The 2-DE analysis of the serum samples revealed that sorcin was upregulated in six out of 29 neoadjuvant chemotherapy (NAC)-sensitive patients and, in those who developed multidrug resistance, sorcin was upregulated in 15 out of 21 patients (P&lt;0.01).	nac	119-122	sorcin	Homo sapiens	193-199
25364442-8	2014	It was found that the expression of p-mTOR and p-4E-BP1 was downregulated following NAC.	nac	84-87	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	49-55
25364401-9	2014	In conclusion, sorcin expression in the human serum of breast cancer patients who are resistant to NAC was elevated when compared with that of NAC-sensitive patients.	nac	99-102	sorcin	Homo sapiens	15-21
25364442-9	2014	The decrease in mTOR expression following NAC was found to positively correlate with HER2 expression and the reduction of tumor sizes.	nac	42-45	mechanistic target of rapamycin kinase	Homo sapiens	16-20
25364401-9	2014	In conclusion, sorcin expression in the human serum of breast cancer patients who are resistant to NAC was elevated when compared with that of NAC-sensitive patients.	nac	143-146	sorcin	Homo sapiens	15-21
25364442-9	2014	The decrease in mTOR expression following NAC was found to positively correlate with HER2 expression and the reduction of tumor sizes.	nac	42-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	85-89
25400769-13	2014	CONCLUSIONS: Our results suggest that Ki67 expression in HR-negative breast cancer may improve the assessment of pathological response after NAC, and Ki67 score in residual tumor was an independent prognosticator for DFS in the HR-negative breast cancer patients.	nac	141-144	nuclear receptor subfamily 4 group A member 1	Homo sapiens	57-59
25364442-10	2014	The high expression of p-mTOR and p-4E-BP1 in pre-NAC specimens was associated with poor disease-free survival (DFS).	nac	50-53	mechanistic target of rapamycin kinase	Homo sapiens	25-29
25364442-10	2014	The high expression of p-mTOR and p-4E-BP1 in pre-NAC specimens was associated with poor disease-free survival (DFS).	nac	50-53	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	36-42
25364442-11	2014	Furthermore, the high expression of p-mTOR in post-NAC specimens was associated with poor DFS, regardless of whether the expression was high or low in the pre-NAC specimens.	nac	51-54	mechanistic target of rapamycin kinase	Homo sapiens	38-42
25364442-11	2014	Furthermore, the high expression of p-mTOR in post-NAC specimens was associated with poor DFS, regardless of whether the expression was high or low in the pre-NAC specimens.	nac	159-162	mechanistic target of rapamycin kinase	Homo sapiens	38-42
25364442-12	2014	In conclusion, NAC was found to decrease the expression levels of p-mTOR and p-4E-BP1.	nac	15-18	mechanistic target of rapamycin kinase	Homo sapiens	68-72
25364442-12	2014	In conclusion, NAC was found to decrease the expression levels of p-mTOR and p-4E-BP1.	nac	15-18	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	79-85
25364442-13	2014	The p-mTOR expression post-NAC may potentially serve as a predictor for DFS.	nac	27-30	mechanistic target of rapamycin kinase	Homo sapiens	6-10
25364442-14	2014	However, further study is required to clarify the mechanism and to evaluate the predictive value of the phosphatidylinositol 3-kinase/Akt/mTOR/4E-BP1 pathway in NAC.	nac	161-164	AKT serine/threonine kinase 1	Homo sapiens	134-137
25364442-14	2014	However, further study is required to clarify the mechanism and to evaluate the predictive value of the phosphatidylinositol 3-kinase/Akt/mTOR/4E-BP1 pathway in NAC.	nac	161-164	mechanistic target of rapamycin kinase	Homo sapiens	138-142
25364442-14	2014	However, further study is required to clarify the mechanism and to evaluate the predictive value of the phosphatidylinositol 3-kinase/Akt/mTOR/4E-BP1 pathway in NAC.	nac	161-164	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	143-149
25279188-1	2014	The aim of the present study was to investigate whether breast cancer patients with changes from positive to negative in the hormone receptor following neoadjuvant chemotherapy (NAC) could benefit from adjuvant endocrine therapy (ET).	nac	178-181	nuclear receptor subfamily 4 group A member 1	Homo sapiens	125-141
25279188-2	2014	Between December 2000 and November 2010, 97 eligible patients with a positive-to-negative switch of the hormone receptor status following NAC were identified.	nac	138-141	nuclear receptor subfamily 4 group A member 1	Homo sapiens	104-120
25279188-8	2014	The present study revealed that patients with the hormone receptor that was altered from positive to negative following NAC benefit from ET, and the hormone receptor status should be evaluated not only in specimens obtained during post-NAC surgery, but also in specimens biopsied prior to NAC.	nac	120-123	nuclear receptor subfamily 4 group A member 1	Homo sapiens	50-66
25279188-8	2014	The present study revealed that patients with the hormone receptor that was altered from positive to negative following NAC benefit from ET, and the hormone receptor status should be evaluated not only in specimens obtained during post-NAC surgery, but also in specimens biopsied prior to NAC.	nac	236-239	nuclear receptor subfamily 4 group A member 1	Homo sapiens	50-66
25279188-8	2014	The present study revealed that patients with the hormone receptor that was altered from positive to negative following NAC benefit from ET, and the hormone receptor status should be evaluated not only in specimens obtained during post-NAC surgery, but also in specimens biopsied prior to NAC.	nac	236-239	nuclear receptor subfamily 4 group A member 1	Homo sapiens	149-165
25279188-8	2014	The present study revealed that patients with the hormone receptor that was altered from positive to negative following NAC benefit from ET, and the hormone receptor status should be evaluated not only in specimens obtained during post-NAC surgery, but also in specimens biopsied prior to NAC.	nac	236-239	nuclear receptor subfamily 4 group A member 1	Homo sapiens	50-66
25279188-8	2014	The present study revealed that patients with the hormone receptor that was altered from positive to negative following NAC benefit from ET, and the hormone receptor status should be evaluated not only in specimens obtained during post-NAC surgery, but also in specimens biopsied prior to NAC.	nac	236-239	nuclear receptor subfamily 4 group A member 1	Homo sapiens	149-165
24986572-2	2014	We performed retrospective analysis of 157 patients with primary breast cancer with ER/PR-positive and HER2-negative subtype who were treated with NAC, followed by definitive surgical resection.	nac	147-150	erb-b2 receptor tyrosine kinase 2	Homo sapiens	103-107
24986572-8	2014	The NLR is an independent prognostic factor for RFS and OS in breast cancer patients with ER/PR-positive and HER2-negative subtype receiving NAC.	nac	141-144	erb-b2 receptor tyrosine kinase 2	Homo sapiens	109-113
25369196-1	2014	NAC (NAM, ATAF1, 2 and CUC2) family is a plant-specific transcription factor and it controls various plant developmental processes.	nac	0-3	Protein CUP-SHAPED COTYLEDON 2	Zea mays	23-27
25159484-13	2014	CONCLUSIONS: Downstaging by NAC in IB1 and IB2 cervical cancer before fertility-sparing surgery is still an experimental procedure, but shows some promise.	nac	28-31	mitogen-activated protein kinase 8 interacting protein 1	Homo sapiens	35-38
24856234-9	2014	Breast tumor response to NAC varied among the different MS, this being lowest in luminal A (21.5%) and highest in non-luminal HER2+ group (80%).	nac	25-28	erb-b2 receptor tyrosine kinase 2	Homo sapiens	126-130
25200445-1	2014	Several trials have confirmed that the pathological complete response (pCR) rates after neoadjuvant chemotherapy (NAC) are significantly lower in HER2-positive/ER-positive patients than in HER2-positive/ER-negative patients.	nac	114-117	erb-b2 receptor tyrosine kinase 2	Homo sapiens	146-150
25200445-1	2014	Several trials have confirmed that the pathological complete response (pCR) rates after neoadjuvant chemotherapy (NAC) are significantly lower in HER2-positive/ER-positive patients than in HER2-positive/ER-negative patients.	nac	114-117	erb-b2 receptor tyrosine kinase 2	Homo sapiens	189-193
25200445-2	2014	To understand this phenomenon, we investigated the association between NAC resistance and CCND1, which is frequently overexpressed in ER-positive tumors.	nac	71-74	cyclin D1	Homo sapiens	90-95
25536590-6	2014	ER and PR discordance was detected in 10 (12.5%) and 17 (21.2%) patients in the NAC group and in 1 (1.8%) and 2 (3.7%) patients in the control group (p=0.04 and p=0.005, respectively).	nac	80-83	progesterone receptor	Homo sapiens	7-9
25536590-10	2014	CONCLUSION: NAC might cause alterations in ER, PR or HER2//neu status in breast cancer, and they should be re-tested in the residual tumor after NAC to optimize adjuvant therapy.	nac	12-15	progesterone receptor	Homo sapiens	47-49
25536590-10	2014	CONCLUSION: NAC might cause alterations in ER, PR or HER2//neu status in breast cancer, and they should be re-tested in the residual tumor after NAC to optimize adjuvant therapy.	nac	12-15	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-57
25536590-10	2014	CONCLUSION: NAC might cause alterations in ER, PR or HER2//neu status in breast cancer, and they should be re-tested in the residual tumor after NAC to optimize adjuvant therapy.	nac	12-15	erb-b2 receptor tyrosine kinase 2	Homo sapiens	59-62
25248902-5	2014	S-1/CDDP plus trastuzumab therapy as NAC for HER2-positive, advanced gastric cancer appears to be an effective treatment.	nac	37-40	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-49
25016361-11	2014	Nevertheless, pretreatment of the cells with MK-801, TTFA and DPI significantly reduced Hcy-stimulated superoxide anion generation, and antioxidant NAC decreased Hcy-induced CRP expression in VSMCs.	nac	148-151	C-reactive protein	Rattus norvegicus	174-177
25016361-12	2014	Additionally, PD98059, SB205380 or PDTC antagonized Hcy-induced CRP expression, and MK-801, NAC, PD98059 or SB205380 inhibited Hcy-activated phosphorylations of ERK1/2 and p38.	nac	92-95	mitogen activated protein kinase 3	Rattus norvegicus	161-167
25016361-12	2014	Additionally, PD98059, SB205380 or PDTC antagonized Hcy-induced CRP expression, and MK-801, NAC, PD98059 or SB205380 inhibited Hcy-activated phosphorylations of ERK1/2 and p38.	nac	92-95	mitogen activated protein kinase 14	Rattus norvegicus	172-175
25109280-8	2014	Antioxidant NAC decreased aldosterone-induced CRP expression and ERK1/2 phosphorylation.	nac	12-15	C-reactive protein	Rattus norvegicus	46-49
25109280-8	2014	Antioxidant NAC decreased aldosterone-induced CRP expression and ERK1/2 phosphorylation.	nac	12-15	mitogen activated protein kinase 3	Rattus norvegicus	65-71
24739359-2	2014	This study investigates the effects of bilateral post-training intra-nucleus accumbens (NAc) shell administrations of glutamate NMDA receptor agents on memory impairment induced by cannabinoid CB1 receptor activation during a step-through inhibitory avoidance (IA) task.	nac	88-91	cannabinoid receptor 1	Homo sapiens	193-196
25148240-2	2014	In Arabidopsis, secondary wall biosynthesis in the xylem conducting cells, vessels, has been shown to be regulated by two VASCULAR-RELATED NAC-DOMAIN (VND) genes, VND6 and VND7.	nac	139-142	NAC-domain protein 101	Arabidopsis thaliana	163-167
25148240-2	2014	In Arabidopsis, secondary wall biosynthesis in the xylem conducting cells, vessels, has been shown to be regulated by two VASCULAR-RELATED NAC-DOMAIN (VND) genes, VND6 and VND7.	nac	139-142	vascular related NAC-domain protein 7	Arabidopsis thaliana	172-176
25148240-10	2014	Furthermore, transactivation analysis revealed that VND1 to VND5 could activate expression of the GUS reporter gene driven by the secondary wall NAC binding element (SNBE).	nac	145-148	vascular related NAC-domain protein 1	Arabidopsis thaliana	52-56
25148240-10	2014	Furthermore, transactivation analysis revealed that VND1 to VND5 could activate expression of the GUS reporter gene driven by the secondary wall NAC binding element (SNBE).	nac	145-148	NAC (No apical meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	60-64
25148240-11	2014	Together, these results demonstrate that VND1 to VND5 possess functions similar to that of the SND1 secondary wall NAC and are transcriptional regulators of secondary wall biosynthesis in vessels.	nac	115-118	vascular related NAC-domain protein 1	Arabidopsis thaliana	41-45
25148240-11	2014	Together, these results demonstrate that VND1 to VND5 possess functions similar to that of the SND1 secondary wall NAC and are transcriptional regulators of secondary wall biosynthesis in vessels.	nac	115-118	NAC (No apical meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	49-53
25148240-11	2014	Together, these results demonstrate that VND1 to VND5 possess functions similar to that of the SND1 secondary wall NAC and are transcriptional regulators of secondary wall biosynthesis in vessels.	nac	115-118	NAC domain containing protein 12	Arabidopsis thaliana	95-99
24739359-7	2014	The data indicated that NMDA receptor mechanism(s), at least partly, play(s) a role in modulating the effect of ACPA on memory consolidation in the NAc shell.	nac	148-151	proteinase 3	Homo sapiens	112-116
24814255-2	2014	The aim of this study was to determine the predictive or prognostic impact of MET and RON in breast cancer patients treated with neoadjuvant chemotherapy (NAC).	nac	155-158	macrophage stimulating 1 receptor	Homo sapiens	86-89
24647576-11	2014	CONCLUSION: In HER2-positive breast cancer, very low tumor residual metabolism after the first cycle of NAC (SUVmax &lt; 2.1) was the main predictor of pCR.	nac	104-107	erb-b2 receptor tyrosine kinase 2	Homo sapiens	15-19
24659488-10	2014	Transient transactivation assays further demonstrated that ORE1 and AtNAP could activate common as well as differential NAC TF targets.	nac	120-123	NAC domain containing protein 6	Arabidopsis thaliana	59-63
24951508-3	2014	PS1 encodes a plant-specific NAC (no apical meristem, Arabidopsis ATAF1/2, and cup-shaped cotyledon2) transcriptional activator, Oryza sativa NAC-like, activated by apetala3/pistillata (OsNAP).	nac	29-32	Presenilin-1	Arabidopsis thaliana	0-3
24951508-3	2014	PS1 encodes a plant-specific NAC (no apical meristem, Arabidopsis ATAF1/2, and cup-shaped cotyledon2) transcriptional activator, Oryza sativa NAC-like, activated by apetala3/pistillata (OsNAP).	nac	29-32	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	66-73
24669777-6	2014	RESULTS: SR X-ray irradiation produced dose-dependent increases in poly(ADP-ribose) (PAR) formation - an index of PARP activation, which can be prevented by NAC administration.	nac	157-160	poly(ADP-ribose) polymerase 1	Homo sapiens	114-118
24659488-10	2014	Transient transactivation assays further demonstrated that ORE1 and AtNAP could activate common as well as differential NAC TF targets.	nac	120-123	NAC-like, activated by AP3/PI	Arabidopsis thaliana	68-73
25120787-1	2014	BACKGROUND: To investigate the prognostic value of hormone receptor (HR) status conversion after neoadjuvant chemotherapy (NAC) in patients with primary breast cancer.	nac	123-126	nuclear receptor subfamily 4 group A member 1	Homo sapiens	51-67
25005917-4	2014	We studied the stomatal immunity of tomato (Solanum lycopersicum) and report here the distinct roles of two homologous NAC (for NAM, ATAF1,2, and CUC2) transcription factors, JA2 (for jasmonic acid2) and JA2L (for JA2-like), in regulating pathogen-triggered stomatal movement.	nac	119-122	NO APICAL MERISTEM	Solanum lycopersicum	128-131
25005917-4	2014	We studied the stomatal immunity of tomato (Solanum lycopersicum) and report here the distinct roles of two homologous NAC (for NAM, ATAF1,2, and CUC2) transcription factors, JA2 (for jasmonic acid2) and JA2L (for JA2-like), in regulating pathogen-triggered stomatal movement.	nac	119-122	NAC domain-containing protein JA2L	Solanum lycopersicum	204-208
25005917-4	2014	We studied the stomatal immunity of tomato (Solanum lycopersicum) and report here the distinct roles of two homologous NAC (for NAM, ATAF1,2, and CUC2) transcription factors, JA2 (for jasmonic acid2) and JA2L (for JA2-like), in regulating pathogen-triggered stomatal movement.	nac	119-122	NAC domain-containing protein JA2L	Solanum lycopersicum	214-222
25120787-5	2014	RESULTS: In total, 15.7% of patients had HR status change after NAC.	nac	64-67	nuclear receptor subfamily 4 group A member 1	Homo sapiens	41-43
25120787-8	2014	CONCLUSIONS: The switch of HR status after NAC is remarkable for breast cancer.	nac	43-46	nuclear receptor subfamily 4 group A member 1	Homo sapiens	27-29
24441101-6	2014	As IL-17 was significantly upregulated by alpha-NAC, we assessed signal transduction in PBMCs and found signal transducer and activator of transcription 3 phosphorylation in alpha-NAC-stimulated cells.	nac	48-51	interleukin 17A	Homo sapiens	3-8
24893880-4	2014	The aim of this study was thus to clarify the correlation between expression of the hypoxic marker carbonic anhydrase-9 (CA9) and chemosensitivity to NAC as well as prognosis of breast cancer patients.	nac	150-153	carbonic anhydrase 9	Homo sapiens	121-124
24893880-11	2014	The Kaplan-Meier survival curve revealed a significant negative correlation (p=0.013) between the disease-free survival (DFS) and the CA 9 expression in resected tissues after NAC.	nac	176-179	carbonic anhydrase 9	Homo sapiens	134-138
24441101-6	2014	As IL-17 was significantly upregulated by alpha-NAC, we assessed signal transduction in PBMCs and found signal transducer and activator of transcription 3 phosphorylation in alpha-NAC-stimulated cells.	nac	48-51	signal transducer and activator of transcription 3	Homo sapiens	104-154
24977004-9	2014	RESULTS: The P-gp expression before NAC was used to evaluate the therapeutic effect of NAC.	nac	87-90	ATP binding cassette subfamily B member 1	Homo sapiens	13-17
24985174-5	2014	RESULTS: (1)The average ROS fluorescence value of NAC+dibucaine group was lower than that of dibucaine group(0.66 +- 0.11 vs 1.06 +- 0.08, P&lt;0.01), while that of NAC+thrombin group was also lower than that of thrombin group(0.45 +- 0.05 vs 0.71 +- 0.11, P=0.001).	nac	50-53	coagulation factor II, thrombin	Homo sapiens	169-177
24977004-10	2014	The up-regulation of P-gp expression after NAC was associated with poor therapeutic effect (P=0.0011).	nac	43-46	ATP binding cassette subfamily B member 1	Homo sapiens	21-25
24977004-15	2014	The change in P-gp expression, from negative to positive following NAC treatment, indicated the emergence of drug resistance resulting from chemotherapy.	nac	67-70	ATP binding cassette subfamily B member 1	Homo sapiens	14-18
24690671-3	2014	HuYou15) and found that it showed high homology (84% at the amino acid level) with a NAC protein called AtRD26/ANAC072.	nac	85-88	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	104-110
24985174-5	2014	RESULTS: (1)The average ROS fluorescence value of NAC+dibucaine group was lower than that of dibucaine group(0.66 +- 0.11 vs 1.06 +- 0.08, P&lt;0.01), while that of NAC+thrombin group was also lower than that of thrombin group(0.45 +- 0.05 vs 0.71 +- 0.11, P=0.001).	nac	50-53	coagulation factor II, thrombin	Homo sapiens	212-220
24985174-6	2014	(2)The percentage of platelets with normal  psim in NAC+Dibucaine group was higher than that of dibucaine group[(86.30 +- 9.37)% vs (13.52 +- 3.01)%, P=0.000], while that of NAC+thrombin group was also higher than that of thrombin group[(93.00 +- 3.03)% vs (76.58 +- 5.28)%, P=0.000].	nac	52-55	coagulation factor II, thrombin	Homo sapiens	178-186
24985174-6	2014	(2)The percentage of platelets with normal  psim in NAC+Dibucaine group was higher than that of dibucaine group[(86.30 +- 9.37)% vs (13.52 +- 3.01)%, P=0.000], while that of NAC+thrombin group was also higher than that of thrombin group[(93.00 +- 3.03)% vs (76.58 +- 5.28)%, P=0.000].	nac	52-55	coagulation factor II, thrombin	Homo sapiens	222-230
24985174-8	2014	(4)The expression of anti-apoptosis protein Bcl-xL of NAC+dibucaine group was significantly higher than that of the dibucaine group, while that of NAC+thrombin group was also higher than that of thrombin group.	nac	54-57	BCL2 like 1	Homo sapiens	44-50
24985174-8	2014	(4)The expression of anti-apoptosis protein Bcl-xL of NAC+dibucaine group was significantly higher than that of the dibucaine group, while that of NAC+thrombin group was also higher than that of thrombin group.	nac	54-57	coagulation factor II, thrombin	Homo sapiens	195-203
24985174-8	2014	(4)The expression of anti-apoptosis protein Bcl-xL of NAC+dibucaine group was significantly higher than that of the dibucaine group, while that of NAC+thrombin group was also higher than that of thrombin group.	nac	147-150	BCL2 like 1	Homo sapiens	44-50
24985174-9	2014	CONCLUSION: Through the regulation of ROS, NAC could inhibit the platelet apoptosis induced by dibucaine or thrombin.	nac	43-46	coagulation factor II, thrombin	Homo sapiens	108-116
24892001-9	2014	Estrogen receptor (ER)-positive cancers, HER2-negative cancers, and presence of intratumoral necrosis were significantly associated with the NAC non-response.	nac	141-144	estrogen receptor 1	Homo sapiens	0-17
24892001-9	2014	Estrogen receptor (ER)-positive cancers, HER2-negative cancers, and presence of intratumoral necrosis were significantly associated with the NAC non-response.	nac	141-144	estrogen receptor 1	Homo sapiens	19-21
24892001-11	2014	ER-positivity, HER2-negativity, and presence of intratumoral necrosis were significantly associated with NAC non-response.	nac	105-108	estrogen receptor 1	Homo sapiens	0-2
24892001-9	2014	Estrogen receptor (ER)-positive cancers, HER2-negative cancers, and presence of intratumoral necrosis were significantly associated with the NAC non-response.	nac	141-144	erb-b2 receptor tyrosine kinase 2	Homo sapiens	41-45
24671357-2	2014	The aim of this study was to evaluate expression levels of OATP1A2 and OCT6 as a predictor of response to neoadjuvant chemotherapy (NAC) in breast cancer.	nac	132-135	solute carrier organic anion transporter family member 1A2	Homo sapiens	59-66
24671357-2	2014	The aim of this study was to evaluate expression levels of OATP1A2 and OCT6 as a predictor of response to neoadjuvant chemotherapy (NAC) in breast cancer.	nac	132-135	solute carrier family 22 member 16	Homo sapiens	71-75
24762066-2	2014	Since expression of aldehyde dehydrogenase-1 (ALDH1) is associated with the stem-like properties of self-renewal and innate chemoresistance in breast cancer, we asked whether expression in serial tumor samples treated with NAC could identify women more likely to benefit from this therapy.	nac	223-226	aldehyde dehydrogenase 1 family member A1	Homo sapiens	46-51
24662134-1	2014	BACKGROUND: The aim of this study was to evaluate association of expression of survivin and p53 with the effects of neoadjuvant chemotherapy (NAC) in patients with advanced ovarian cancer (AOC).	nac	142-145	tumor protein p53	Homo sapiens	92-95
24500791-6	2014	RESULTS: Infusion of NPY into either VTA or NAc increased the motivation to respond for sucrose, whereas infusion of NPY in either NAc or LH increased sucrose consumption.	nac	44-47	neuropeptide Y	Homo sapiens	21-24
24500791-6	2014	RESULTS: Infusion of NPY into either VTA or NAc increased the motivation to respond for sucrose, whereas infusion of NPY in either NAc or LH increased sucrose consumption.	nac	131-134	neuropeptide Y	Homo sapiens	117-120
24682461-2	2014	NAC (NAM, ATAF1, 2, CUC2) transcription factors constitute the largest families of plant-specific transcription factors, known to be involved in various growth or developmental processes and in regulation of response to environmental stresses.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	5-8
24682461-2	2014	NAC (NAM, ATAF1, 2, CUC2) transcription factors constitute the largest families of plant-specific transcription factors, known to be involved in various growth or developmental processes and in regulation of response to environmental stresses.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	10-18
24682461-2	2014	NAC (NAM, ATAF1, 2, CUC2) transcription factors constitute the largest families of plant-specific transcription factors, known to be involved in various growth or developmental processes and in regulation of response to environmental stresses.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	20-24
24604734-3	2014	However, the functions of the miR164-targeted NAC genes in crops are poorly deciphered.	nac	46-49	MIR164a	Arabidopsis thaliana	30-36
24604734-4	2014	In this study, the conserved features of six miR164-targeted NAC genes (OMTN1-OMTN6) in rice are described, and evidence is provided that four of them confer a negative regulatory role in drought resistance.	nac	61-64	MIR164a	Arabidopsis thaliana	45-51
24604734-12	2014	The results suggest that the conserved miR164-targeted NAC genes may be negative regulators of drought tolerance in rice, in addition to their reported roles in development.	nac	55-58	MIR164a	Arabidopsis thaliana	39-45
24762066-17	2014	The up-regulation of ALDH1 after NAC predicts poor survival in locally advanced breast cancer.	nac	33-36	aldehyde dehydrogenase 1 family member A1	Homo sapiens	21-26
24736530-2	2014	In particular, we analysed the association of NAC response and pre- and post-NAC expression of the main multidrug resistance (MDR) genes--ABCB1, ABCC1, ABCC5, ABCG1, and ABCG2, with the presence of different morphological structures in breast tumors.	nac	46-49	ATP binding cassette subfamily B member 1	Homo sapiens	138-143
24736530-2	2014	In particular, we analysed the association of NAC response and pre- and post-NAC expression of the main multidrug resistance (MDR) genes--ABCB1, ABCC1, ABCC5, ABCG1, and ABCG2, with the presence of different morphological structures in breast tumors.	nac	46-49	ATP binding cassette subfamily C member 1	Homo sapiens	145-150
24736530-2	2014	In particular, we analysed the association of NAC response and pre- and post-NAC expression of the main multidrug resistance (MDR) genes--ABCB1, ABCC1, ABCC5, ABCG1, and ABCG2, with the presence of different morphological structures in breast tumors.	nac	46-49	ATP binding cassette subfamily C member 5	Homo sapiens	152-157
24736530-2	2014	In particular, we analysed the association of NAC response and pre- and post-NAC expression of the main multidrug resistance (MDR) genes--ABCB1, ABCC1, ABCC5, ABCG1, and ABCG2, with the presence of different morphological structures in breast tumors.	nac	46-49	ATP binding cassette subfamily G member 1	Homo sapiens	159-164
24736530-2	2014	In particular, we analysed the association of NAC response and pre- and post-NAC expression of the main multidrug resistance (MDR) genes--ABCB1, ABCC1, ABCC5, ABCG1, and ABCG2, with the presence of different morphological structures in breast tumors.	nac	46-49	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	170-175
24736530-2	2014	In particular, we analysed the association of NAC response and pre- and post-NAC expression of the main multidrug resistance (MDR) genes--ABCB1, ABCC1, ABCC5, ABCG1, and ABCG2, with the presence of different morphological structures in breast tumors.	nac	77-80	ATP binding cassette subfamily B member 1	Homo sapiens	138-143
24736530-2	2014	In particular, we analysed the association of NAC response and pre- and post-NAC expression of the main multidrug resistance (MDR) genes--ABCB1, ABCC1, ABCC5, ABCG1, and ABCG2, with the presence of different morphological structures in breast tumors.	nac	77-80	ATP binding cassette subfamily C member 1	Homo sapiens	145-150
24736530-2	2014	In particular, we analysed the association of NAC response and pre- and post-NAC expression of the main multidrug resistance (MDR) genes--ABCB1, ABCC1, ABCC5, ABCG1, and ABCG2, with the presence of different morphological structures in breast tumors.	nac	77-80	ATP binding cassette subfamily C member 5	Homo sapiens	152-157
23592280-10	2014	CONCLUSIONS: Even if the indication for adjuvant treatment is limited to only high-risk patients, about 70 % of stage IB2-IIB patients with bulky cervical cancer could be cured by NAC followed by radical hysterectomy.	nac	180-183	mitogen-activated protein kinase 8 interacting protein 2	Homo sapiens	118-121
24560901-1	2014	Previous studies in rats have shown that microinjections of cocaine- and amphetamine-regulated transcript (CART) peptide into the nucleus accumbens (NAc; the area of the brain that mediates drug reward and reinforcement) attenuate the locomotor effects of psychostimulants.	nac	149-152	CART prepropeptide	Rattus norvegicus	60-105
24560901-1	2014	Previous studies in rats have shown that microinjections of cocaine- and amphetamine-regulated transcript (CART) peptide into the nucleus accumbens (NAc; the area of the brain that mediates drug reward and reinforcement) attenuate the locomotor effects of psychostimulants.	nac	149-152	CART prepropeptide	Rattus norvegicus	107-111
24560901-7	2014	In vivo, repeated microinjections of CART (55-102) peptide (2mug/1mul/side) into the NAc over a 5-day period had no effect on behavioral activity but blocked cocaine-induced locomotor activity.	nac	85-88	CART prepropeptide	Rattus norvegicus	37-41
24504189-9	2014	CD44v6 or ABCG2 positivity in NAC-treated patients was significantly associated with tumor local recurrence.	nac	30-33	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	10-15
24157259-12	2014	HER2 subtypes are less likely to have axillary involvement after NAC and may demand different management.	nac	65-68	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
24280010-3	2014	Focusing on the NAc core and shell, the present study aims to provide further findings for our understanding of the relation between behavioural sensitization to morphine and Hsp70 at transcriptional and functional levels in rats.	nac	16-19	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	175-180
24280010-5	2014	Secondly, Hsp70 protein expression in the NAc core was time- and dose-relatedly induced during the development of behavioural sensitization to a single morphine exposure in rats, and Pearson analysis indicated a positive correlation between behavioural sensitization and Hsp70 expression in NAc core.	nac	42-45	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	10-15
24280010-5	2014	Secondly, Hsp70 protein expression in the NAc core was time- and dose-relatedly induced during the development of behavioural sensitization to a single morphine exposure in rats, and Pearson analysis indicated a positive correlation between behavioural sensitization and Hsp70 expression in NAc core.	nac	42-45	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	271-276
24280010-5	2014	Secondly, Hsp70 protein expression in the NAc core was time- and dose-relatedly induced during the development of behavioural sensitization to a single morphine exposure in rats, and Pearson analysis indicated a positive correlation between behavioural sensitization and Hsp70 expression in NAc core.	nac	291-294	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	10-15
24280010-6	2014	Thirdly, at the transcriptional level, intra-NAc core injection of the specific heat shock factor-I (HSF-I) inhibitor N-Formyl-3,4-methylenedioxy-benzylidine-gamma-butyrolactam (KNK437) suppressed Hsp70 expression and the development of behavioural sensitization, while the HSF-I specific inducer geranylgeranylacetone (GGA) promoted both of them.	nac	45-48	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	197-202
24280010-8	2014	Finally, both the functional inhibition of Hsp70 ATPase activity by methylene blue (MB), and the antagonism of Hsp70 substrate binding site (SBD) activity by pifithrin-mu (PES) impaired the development of behavioural sensitization when they were microinjected into the NAc core.	nac	269-272	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	111-116
24570356-1	2014	NAC (NAM/ATAF/CUC) transcription factors regulate the expression of the target genes by formation of NAC-DNA complex, which are involved in development, stress responses and nutrient distribution in many metaphyta plants.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	5-17
24570356-1	2014	NAC (NAM/ATAF/CUC) transcription factors regulate the expression of the target genes by formation of NAC-DNA complex, which are involved in development, stress responses and nutrient distribution in many metaphyta plants.	nac	101-104	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	5-17
24128392-2	2014	NAC [NAM (no apical meristem), ATAF (Arabidopsis transcription activation factor) and CUC (cup-shaped cotyledon)] transcription factors, usually as the targets of miR164, play important roles in the regulation of plant development and responses to abiotic and biotic stresses.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	5-8
24128392-2	2014	NAC [NAM (no apical meristem), ATAF (Arabidopsis transcription activation factor) and CUC (cup-shaped cotyledon)] transcription factors, usually as the targets of miR164, play important roles in the regulation of plant development and responses to abiotic and biotic stresses.	nac	0-3	MIR164a	Arabidopsis thaliana	163-169
24258007-14	2014	CONCLUSION: In luminal HER2-negative breast tumours, tumour metabolism at baseline and changes after the first course of NAC are early surrogate markers of patients" survival.	nac	121-124	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
24108388-9	2014	The antioxidant and MG scavenger NAC prevented the MG-induced GLUT4 translocation.	nac	33-36	solute carrier family 2 member 4	Rattus norvegicus	62-67
24549030-4	2014	We demonstrate that a NAC (NAM, ATAF1/2 and CUC2) gene shattering1-5 (SHAT1-5) functionally activates secondary wall biosynthesis and promotes the significant thickening of FCC secondary walls by expression at 15-fold the level of the wild allele, which is attributed to functional disruption of the upstream repressor.	nac	22-25	NAC domain-containing protein 43-like	Glycine max	70-77
23786573-1	2014	The incidence of invasive candidiasis caused by non-albicans Candida (NAC) spp.	nac	70-73	histocompatibility minor 13	Homo sapiens	75-78
24080311-7	2014	RESULTS: The level of GRM3 mRNA was higher in APA than in CPA (P=0.0086) or NAC (P=0.0022).	nac	76-79	glutamate metabotropic receptor 3	Homo sapiens	22-26
24266856-5	2014	RESULTS: Discordant RRM1 expression (low versus high) was observed in 32% and 43% of paired diagnostic and subsequent resection specimens in the OP group and NAC group, respectively (P = 0.913).	nac	158-161	ribonucleotide reductase catalytic subunit M1	Homo sapiens	20-24
24266856-6	2014	Ten (33%) and 12 (23%) tumours in the NAC group and the OP group, respectively, had increased RRM1 expression in the resection specimens (P = 0.289), and 12 (40%) and 19 (36%) tumours had decreased expression (P = 0.707).	nac	38-41	ribonucleotide reductase catalytic subunit M1	Homo sapiens	94-98
24323506-0	2014	The NAC-like gene ANTHER INDEHISCENCE FACTOR acts as a repressor that controls anther dehiscence by regulating genes in the jasmonate biosynthesis pathway in Arabidopsis.	nac	4-7	NAC domain containing protein 53	Arabidopsis thaliana	18-44
24323506-1	2014	ANTHER INDEHISCENCE FACTOR (AIF), a NAC-like gene, was identified in Arabidopsis.	nac	36-39	NAC domain containing protein 53	Arabidopsis thaliana	0-26
24323506-1	2014	ANTHER INDEHISCENCE FACTOR (AIF), a NAC-like gene, was identified in Arabidopsis.	nac	36-39	NAC domain containing protein 53	Arabidopsis thaliana	28-31
24465446-1	2014	In Arabidopsis, NAC (NAM, ATAF and CUC) transcription factors have been found to promote lateral root number through the auxin signaling pathway.	nac	16-19	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	21-24
24265273-0	2014	A new tomato NAC (NAM/ATAF1/2/CUC2) transcription factor, SlNAC4, functions as a positive regulator of fruit ripening and carotenoid accumulation.	nac	13-16	NO APICAL MERISTEM	Solanum lycopersicum	18-21
23990108-6	2014	The severe salt stress resulted in decrease in P5CR in NAC-200 cultures.	nac	55-58	pyrroline-5-carboxylate reductase	Cucumis sativus	47-51
24343073-12	2013	CONCLUSION: The results indicate that NAC followed by surgery plus postoperative chemotherapy but no radiotherapy offers a viable option in the treatment of stage IB2-IIB cervical cancer.	nac	38-41	mitogen-activated protein kinase 8 interacting protein 2	Homo sapiens	163-166
24409055-14	2013	Response to NAC was associated with significantly increased DFS (mean DFS; TRG 1-2: 5.1 years, 95%CI: 4.6-5.6 vs TRG 3-5: 2.8 years, 95%CI: 2.2-3.3, P &lt; 0.0001).	nac	12-15	tRNA-Gly (anticodon CCC) 1-1	Homo sapiens	75-82
24409055-14	2013	Response to NAC was associated with significantly increased DFS (mean DFS; TRG 1-2: 5.1 years, 95%CI: 4.6-5.6 vs TRG 3-5: 2.8 years, 95%CI: 2.2-3.3, P &lt; 0.0001).	nac	12-15	tRNA-Gly (anticodon TCC) 1-1	Homo sapiens	113-120
24409055-15	2013	Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC (median DFS; TRG 3-5 and nodal down-staging: 5.533 years, 95%CI: 3.558-7.531 vs TRG 3-5 and no nodal down-staging: 1.114 years, 95%CI: 0.961-1.267, P &lt; 0.0001).	nac	115-118	tRNA-Gly (anticodon TCC) 1-1	Homo sapiens	132-139
24409055-15	2013	Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC (median DFS; TRG 3-5 and nodal down-staging: 5.533 years, 95%CI: 3.558-7.531 vs TRG 3-5 and no nodal down-staging: 1.114 years, 95%CI: 0.961-1.267, P &lt; 0.0001).	nac	115-118	tRNA-Gly (anticodon TCC) 1-1	Homo sapiens	199-206
24183366-1	2013	Previous studies have reported conflicting results regarding the impact of neoadjuvant chemotherapy (NAC) on estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status in breast cancer.	nac	101-104	estrogen receptor 1	Homo sapiens	109-126
24114855-11	2013	When DB analyses were added to SS analyses, the relative increase in HER2+ cases was 13.5% (17.1% for patients with NAC and 23.5% for patients with histological response to NAC, versus 7.1% for patients without NAC, P = 0.4, NS).	nac	116-119	erb-b2 receptor tyrosine kinase 2	Homo sapiens	69-73
24114855-11	2013	When DB analyses were added to SS analyses, the relative increase in HER2+ cases was 13.5% (17.1% for patients with NAC and 23.5% for patients with histological response to NAC, versus 7.1% for patients without NAC, P = 0.4, NS).	nac	173-176	erb-b2 receptor tyrosine kinase 2	Homo sapiens	69-73
24114855-11	2013	When DB analyses were added to SS analyses, the relative increase in HER2+ cases was 13.5% (17.1% for patients with NAC and 23.5% for patients with histological response to NAC, versus 7.1% for patients without NAC, P = 0.4, NS).	nac	173-176	erb-b2 receptor tyrosine kinase 2	Homo sapiens	69-73
24114855-12	2013	Differences between DB and SS HER2 expression could be explained by intratumoral heterogeneity and by a HER2 expression decrease in SS after NAC in responding patients possibly due to a higher chemosensitivity of HER2-positive clones.	nac	141-144	erb-b2 receptor tyrosine kinase 2	Homo sapiens	30-34
24114855-12	2013	Differences between DB and SS HER2 expression could be explained by intratumoral heterogeneity and by a HER2 expression decrease in SS after NAC in responding patients possibly due to a higher chemosensitivity of HER2-positive clones.	nac	141-144	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-108
24114855-12	2013	Differences between DB and SS HER2 expression could be explained by intratumoral heterogeneity and by a HER2 expression decrease in SS after NAC in responding patients possibly due to a higher chemosensitivity of HER2-positive clones.	nac	141-144	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-108
24349491-5	2013	Moreover, we observed that the addition of ROS scavenger, N-acetylcystein (NAC), to palmitate diminished both ER stress and autophagy markers mimicking the effect of mitochondrial overexpression of hOGG1.	nac	75-78	8-oxoguanine DNA glycosylase	Homo sapiens	198-203
23836289-7	2013	Lower intratumoral infiltration of FOXP3+ Tregs after NAC (&lt;3.4/HPF) was significantly associated with higher PCR rates for breast, and close to the significance limit for total (or both for breast and axillary) PCR rates (PCR for breast: 25 vs. 2.9 % for low vs. high Treg, p = 0.001; PCR for breast + axillary tissue: 13.9 vs. 0 %, p = 0.05).	nac	54-57	forkhead box P3	Homo sapiens	35-40
24183366-1	2013	Previous studies have reported conflicting results regarding the impact of neoadjuvant chemotherapy (NAC) on estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status in breast cancer.	nac	101-104	estrogen receptor 1	Homo sapiens	128-130
24183366-1	2013	Previous studies have reported conflicting results regarding the impact of neoadjuvant chemotherapy (NAC) on estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status in breast cancer.	nac	101-104	progesterone receptor	Homo sapiens	133-154
24183366-1	2013	Previous studies have reported conflicting results regarding the impact of neoadjuvant chemotherapy (NAC) on estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status in breast cancer.	nac	101-104	progesterone receptor	Homo sapiens	156-158
24183366-1	2013	Previous studies have reported conflicting results regarding the impact of neoadjuvant chemotherapy (NAC) on estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) status in breast cancer.	nac	101-104	erb-b2 receptor tyrosine kinase 2	Homo sapiens	170-204
24183366-5	2013	Fourteen (12.4%) of 113 patients undergoing NAC showed the ER status modulation in the surgically removed specimen as compared with only 4 (3.9%) of 102 women without NAC (p=0.025).	nac	44-47	estrogen receptor 1	Homo sapiens	59-61
24183366-6	2013	Eighteen (15.9%) of 113 patients given NAC appeared in the PR status alteration in the final surgical specimen, whereas only 7 (6.9%) of 102 patients without NAC did (p=0.038).	nac	39-42	progesterone receptor	Homo sapiens	59-61
24183366-7	2013	The HER2 status shift was found in 17 (15.0%) of 113 patients with NAC and in 6 (5.9%) of 102 patients without NAC, respectively (p=0.030).	nac	67-70	erb-b2 receptor tyrosine kinase 2	Homo sapiens	4-8
24183366-7	2013	The HER2 status shift was found in 17 (15.0%) of 113 patients with NAC and in 6 (5.9%) of 102 patients without NAC, respectively (p=0.030).	nac	111-114	erb-b2 receptor tyrosine kinase 2	Homo sapiens	4-8
24224045-8	2013	Furthermore, several well characterized TF families, for example, WRKY, MYB, NAC, AP2/ERF and zinc finger were shown to be involved in different stresses.	nac	77-80	probable WRKY transcription factor 40	Gossypium hirsutum	66-70
24289519-8	2013	CONCLUSIONS: Reductions in Ki-67, Phospho-p44/42, and pAKT expression are related to the clinical response to anthracycline-based NAC in HER2-positive breast cancer patients.	nac	130-133	erb-b2 receptor tyrosine kinase 2	Homo sapiens	137-141
23489195-1	2013	NAC (NAM-ATAF1, 2-CUC2) family members play important roles in various environmental responses.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	9-14
23489195-2	2013	Here, we cloned a full-length NAC gene (954 bp) from Solanum lycopersicum (SlNAC1).	nac	30-33	NAC domain protein	Solanum lycopersicum	75-81
24224045-8	2013	Furthermore, several well characterized TF families, for example, WRKY, MYB, NAC, AP2/ERF and zinc finger were shown to be involved in different stresses.	nac	77-80	uncharacterized protein LOC107909337	Gossypium hirsutum	72-75
24224045-8	2013	Furthermore, several well characterized TF families, for example, WRKY, MYB, NAC, AP2/ERF and zinc finger were shown to be involved in different stresses.	nac	77-80	ethylene-responsive transcription factor 4	Gossypium hirsutum	86-89
24013633-8	2013	The feaR gene is upregulated by carbon or nitrogen limitation, which we propose reflects regulation of feaR by the cyclic AMP receptor protein (CRP) and the nitrogen assimilation control protein (NAC), respectively.	nac	196-199	catabolite gene activator protein	Escherichia coli	115-142
24393861-6	2013	On immunohistochemistry, MICA expression was positive in 11 of 13 (85%) pancreatic ductal adenocarcinomas in the NAC group, and in 4 of 11 (36%) in the placebo control group.	nac	113-116	MHC class I polypeptide-related sequence A	Homo sapiens	25-29
24393861-7	2013	There was a greater proportion of NKG2D-positive cells in 5 random samples taken from both the NAC groups( 10 of 13, 77%) than in equivalent samples taken from the placebo control group( 3 of 11, 27%).	nac	95-98	killer cell lectin like receptor K1	Homo sapiens	34-39
24393861-8	2013	In addition, CD16-positive cells were more prevalent among NK, CD8, and gammadeltaT cells in the NAC group( 9 of 13, 69%) than in the placebo control group( 3 of 11, 27%).	nac	97-100	Fc gamma receptor IIIa	Homo sapiens	13-17
24393861-8	2013	In addition, CD16-positive cells were more prevalent among NK, CD8, and gammadeltaT cells in the NAC group( 9 of 13, 69%) than in the placebo control group( 3 of 11, 27%).	nac	97-100	CD8a molecule	Homo sapiens	63-66
24013633-8	2013	The feaR gene is upregulated by carbon or nitrogen limitation, which we propose reflects regulation of feaR by the cyclic AMP receptor protein (CRP) and the nitrogen assimilation control protein (NAC), respectively.	nac	196-199	catabolite gene activator protein	Escherichia coli	144-147
23599374-6	2013	The significantly higher expression of peroxiredoxin 1 and significantly lower expression of galectin 1 after NAC treatment were confirmed by Western blot.	nac	110-113	galectin 1	Homo sapiens	93-103
24285786-2	2013	In this study, we provide evidence that the NAC (for NAM, ATAF1/2, and CUC2) TF ANAC096 cooperates with the bZIP-type TFs ABRE binding factor and ABRE binding protein (ABF/AREB) to help plants survive under dehydration and osmotic stress conditions.	nac	44-47	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	53-56
24285786-2	2013	In this study, we provide evidence that the NAC (for NAM, ATAF1/2, and CUC2) TF ANAC096 cooperates with the bZIP-type TFs ABRE binding factor and ABRE binding protein (ABF/AREB) to help plants survive under dehydration and osmotic stress conditions.	nac	44-47	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	58-65
24285786-2	2013	In this study, we provide evidence that the NAC (for NAM, ATAF1/2, and CUC2) TF ANAC096 cooperates with the bZIP-type TFs ABRE binding factor and ABRE binding protein (ABF/AREB) to help plants survive under dehydration and osmotic stress conditions.	nac	44-47	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	71-75
24285786-2	2013	In this study, we provide evidence that the NAC (for NAM, ATAF1/2, and CUC2) TF ANAC096 cooperates with the bZIP-type TFs ABRE binding factor and ABRE binding protein (ABF/AREB) to help plants survive under dehydration and osmotic stress conditions.	nac	44-47	NAC domain containing protein 96	Arabidopsis thaliana	80-87
24107940-4	2013	In DOR-eGFP knock-in mice, we show a persistent, learning-related plasticity in the translocation of DORs to the somatic plasma membrane of cholinergic interneurons (CINs) in the NAc-S during the encoding of the specific stimulus-outcome associations essential for pavlovian-instrumental transfer.	nac	179-182	opioid receptor, delta 1	Mus musculus	3-6
23774252-7	2013	TNF-alpha-enhanced p42/p44 MAPK, p38 MAPK, JNK1/2, and NF-kappaB (p65) phosphorylation and in vivo binding of p65 to the MMP-9 promoter were inhibited by U0126, SB202190, SP600125, NAC, DPI, or APO.	nac	181-184	tumor necrosis factor	Rattus norvegicus	0-9
23774252-7	2013	TNF-alpha-enhanced p42/p44 MAPK, p38 MAPK, JNK1/2, and NF-kappaB (p65) phosphorylation and in vivo binding of p65 to the MMP-9 promoter were inhibited by U0126, SB202190, SP600125, NAC, DPI, or APO.	nac	181-184	synaptotagmin 1	Rattus norvegicus	110-113
23774252-7	2013	TNF-alpha-enhanced p42/p44 MAPK, p38 MAPK, JNK1/2, and NF-kappaB (p65) phosphorylation and in vivo binding of p65 to the MMP-9 promoter were inhibited by U0126, SB202190, SP600125, NAC, DPI, or APO.	nac	181-184	matrix metallopeptidase 9	Rattus norvegicus	121-126
23774252-8	2013	In addition, TNF-alpha-mediated PYK2 phosphorylation was inhibited by NAC, DPI, or APO.	nac	70-73	tumor necrosis factor	Rattus norvegicus	13-22
23774252-8	2013	In addition, TNF-alpha-mediated PYK2 phosphorylation was inhibited by NAC, DPI, or APO.	nac	70-73	protein tyrosine kinase 2 beta	Rattus norvegicus	32-36
24107940-7	2013	The relationship between the induction of membrane DOR expression in CINs and both pavlovian conditioning and pavlovian-instrumental transfer provides a highly specific function for DOR-related modulation in the NAc-S, and it is consistent with an emerging role for striatal CIN activity in the processing of predictive information.	nac	212-215	opioid receptor, delta 1	Mus musculus	51-54
24107940-7	2013	The relationship between the induction of membrane DOR expression in CINs and both pavlovian conditioning and pavlovian-instrumental transfer provides a highly specific function for DOR-related modulation in the NAc-S, and it is consistent with an emerging role for striatal CIN activity in the processing of predictive information.	nac	212-215	opioid receptor, delta 1	Mus musculus	182-185
23846781-10	2013	The sensitivity of post-NAC axillary imaging in detecting persistent LN metastases for cN1-AUS/FNA-positive patients was 69.8 % for US, 61.0 % for MRI, and 63.2 % for PET-CT.	nac	24-27	5'-nucleotidase, cytosolic IA	Homo sapiens	87-90
23690406-7	2013	Stx2a and Stx2c bound to the Pk analog with a terminal GalNAc (NAc-Pk), while Stx1, Stx2b, and Stx2d did not bind to this analog.	nac	58-61	syntaxin 2	Homo sapiens	0-5
23890870-10	2013	CONCLUSIONS: Ki-67 value after NAC and ER status could predict a worse prognosis among LABC patients treated with NAC.	nac	114-117	estrogen receptor 1	Homo sapiens	39-41
23843463-1	2013	The antithrombin (AT) binding properties of heparin and low molecular weight heparins are strongly associated to the presence of the pentasaccharide sequence AGA*IA (A(NAc,6S)-GlcUA-A(NS,3,6S)-I(2S)-A(NS,6S)).	nac	168-171	serpin family C member 1	Homo sapiens	4-16
23940760-7	2013	The effect of TNF-alpha was abolished in the presence of ROS inhibitors as NAC, or DPI.	nac	75-78	tumor necrosis factor	Homo sapiens	14-23
23649897-1	2013	NAC [no apical meristem (NAM), Arabidopsis thaliana transcription activation factor [ATAF1/2] and cup-shaped cotyledon (CUC2)] proteins belong to one of the largest plant-specific transcription factor (TF) families and play important roles in plant development processes, response to biotic and abiotic cues and hormone signalling.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	25-28
23649897-1	2013	NAC [no apical meristem (NAM), Arabidopsis thaliana transcription activation factor [ATAF1/2] and cup-shaped cotyledon (CUC2)] proteins belong to one of the largest plant-specific transcription factor (TF) families and play important roles in plant development processes, response to biotic and abiotic cues and hormone signalling.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	85-92
23649897-1	2013	NAC [no apical meristem (NAM), Arabidopsis thaliana transcription activation factor [ATAF1/2] and cup-shaped cotyledon (CUC2)] proteins belong to one of the largest plant-specific transcription factor (TF) families and play important roles in plant development processes, response to biotic and abiotic cues and hormone signalling.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	120-124
23657466-0	2013	The human skin-associated autoantigen alpha-NAC activates monocytes and dendritic cells via TLR-2 and primes an IL-12-dependent Th1 response.	nac	44-47	toll like receptor 2	Homo sapiens	92-97
23712732-5	2013	NAc-JPH203 accumulates in the bile, and NAc-JPH203 canalicular efflux was significantly decreased in Mrp2-deficient mutant rats (Eisai hyperbilirubinemic rats).	nac	40-43	ATP binding cassette subfamily C member 2	Rattus norvegicus	101-105
23712732-6	2013	JPH203 and NAc-JPH203 are organic anion transporters [organic anion transporting polypeptide (OATP)1B1, OATP1B3, OATP2B1, and OAT3] substrates.	nac	11-14	solute carrier organic anion transporter family member 1A2	Homo sapiens	94-98
23712732-6	2013	JPH203 and NAc-JPH203 are organic anion transporters [organic anion transporting polypeptide (OATP)1B1, OATP1B3, OATP2B1, and OAT3] substrates.	nac	11-14	solute carrier family 22 member 8	Rattus norvegicus	126-130
23690406-7	2013	Stx2a and Stx2c bound to the Pk analog with a terminal GalNAc (NAc-Pk), while Stx1, Stx2b, and Stx2d did not bind to this analog.	nac	58-61	syntaxin 2	Homo sapiens	10-15
23690406-8	2013	Interestingly, the purified Stx2d B subunit bound to NAc-Pk, suggesting that the A subunit of Stx2d interferes with binding.	nac	53-56	syntaxin 2	Homo sapiens	28-32
23690406-8	2013	Interestingly, the purified Stx2d B subunit bound to NAc-Pk, suggesting that the A subunit of Stx2d interferes with binding.	nac	53-56	syntaxin 2	Homo sapiens	94-98
23536356-3	2013	Recent findings have supported the view that beta-synuclein can act as an ameliorating regulator of alpha-synuclein-induced neurotoxicity, having neuroprotective rather than neurodegenerative capabilities, and being nonaggregating due to the absence of most of the aggregation-promoting NAC domain.	nac	287-290	synuclein alpha	Rattus norvegicus	100-115
23883806-8	2013	RESULTS: After NAC, allergic subjects had a significant immediate response of nasal symptoms as well as a significant increase at 5 hours of IL-4, IL-10, and IL-17 and at 2, 5, and 24 hours significantly raising levels of eotaxin-3.	nac	15-18	interleukin 4	Homo sapiens	141-145
23883806-8	2013	RESULTS: After NAC, allergic subjects had a significant immediate response of nasal symptoms as well as a significant increase at 5 hours of IL-4, IL-10, and IL-17 and at 2, 5, and 24 hours significantly raising levels of eotaxin-3.	nac	15-18	interleukin 10	Homo sapiens	147-152
23883806-8	2013	RESULTS: After NAC, allergic subjects had a significant immediate response of nasal symptoms as well as a significant increase at 5 hours of IL-4, IL-10, and IL-17 and at 2, 5, and 24 hours significantly raising levels of eotaxin-3.	nac	15-18	interleukin 17A	Homo sapiens	158-163
23883806-8	2013	RESULTS: After NAC, allergic subjects had a significant immediate response of nasal symptoms as well as a significant increase at 5 hours of IL-4, IL-10, and IL-17 and at 2, 5, and 24 hours significantly raising levels of eotaxin-3.	nac	15-18	C-C motif chemokine ligand 26	Homo sapiens	222-231
23935846-9	2013	Expression of NY-ESO-1 in the NAC cohort was associated with significantly increased response rates (P = 0.03), but not overall survival.	nac	30-33	cancer/testis antigen 1A	Homo sapiens	14-22
23536356-3	2013	Recent findings have supported the view that beta-synuclein can act as an ameliorating regulator of alpha-synuclein-induced neurotoxicity, having neuroprotective rather than neurodegenerative capabilities, and being nonaggregating due to the absence of most of the aggregation-promoting NAC domain.	nac	287-290	synuclein, beta	Rattus norvegicus	45-59
23658771-7	2013	Pgp and MRP1 were significantly up-regulated after exposure to NAC (Wilcoxon signed-rank p = 0.0024 and p&lt;0.0001), while BCRP showed more variation in response to NAC, with frequent up- (59% of cases) and down-regulation (41%) contributing to a lack of significant difference overall.	nac	63-66	ATP binding cassette subfamily B member 1	Homo sapiens	0-3
23523958-11	2013	These observations provide evidence that cannabinoid CB1 receptors in the NAc are involved in development of reward-related behaviors and they can potentiate the rewarding effects of morphine.	nac	74-77	cannabinoid receptor 1	Rattus norvegicus	53-56
23504954-10	2013	CONCLUSIONS: When patients responded to NAC, the majority of ER-positive/HER2 negative tumors exhibited partial tumor shrinkage; and the PET parameters that combined volume and activity measurements, such as TLG, offered better accuracy for early prediction than the SUV(max).	nac	40-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	73-77
23563083-8	2013	BIOLOGICAL SIGNIFICANCE: Basic transcription factor 3 (BTF3), the beta-subunit of NAC, has originally been identified as a basic transcription factor that is both involved in the transcriptional initiation of RNA polymerase II and associated with diverse biological functions.	nac	82-85	basic transcription factor 3	Triticum aestivum	25-53
23563083-8	2013	BIOLOGICAL SIGNIFICANCE: Basic transcription factor 3 (BTF3), the beta-subunit of NAC, has originally been identified as a basic transcription factor that is both involved in the transcriptional initiation of RNA polymerase II and associated with diverse biological functions.	nac	82-85	basic transcription factor 3	Triticum aestivum	55-59
23288619-8	2013	However, this effect was blocked by NAC (5 mM; ROS inhibitor), indicating that AGEs regulate MEK/ERK phosphorylation via ROS.	nac	36-39	Eph receptor B1	Rattus norvegicus	97-100
23843088-6	2013	The maximum tumor dynamic changes in deoxy-hemoglobin increased from less than 7% at cycle 1, day 5 (C1, D5) to 17% at (C1, D28), which indicated a complete response to NAC early during treatment and was subsequently confirmed pathologically at the time of surgery.	nac	169-172	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	101-107
23843088-6	2013	The maximum tumor dynamic changes in deoxy-hemoglobin increased from less than 7% at cycle 1, day 5 (C1, D5) to 17% at (C1, D28), which indicated a complete response to NAC early during treatment and was subsequently confirmed pathologically at the time of surgery.	nac	169-172	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	120-127
23578292-2	2013	ANAC019, ANAC055 and ANAC072 belong to the same clade of NAC domain genes and have overlapping expression patterns.	nac	1-4	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	21-28
23684711-18	2013	CONCLUSION: SLN biopsy after NAC is a feasible and accurate tool in patients with operable breast cancer T1-3, N1 and clinically node-negative after therapy.	nac	29-32	sarcolipin	Homo sapiens	12-15
23458740-6	2013	While CREB is necessary for swim stress-elicited zif268 expression within the nucleus accubmens (NAc) shell and prelimbic cortex (PrL), restraint-stress-elicited comparable increases in zif268 expression within these regions in both wild-type and CREBalphaDelta mutant mice.	nac	97-100	cAMP responsive element binding protein 1	Mus musculus	6-10
23458740-6	2013	While CREB is necessary for swim stress-elicited zif268 expression within the nucleus accubmens (NAc) shell and prelimbic cortex (PrL), restraint-stress-elicited comparable increases in zif268 expression within these regions in both wild-type and CREBalphaDelta mutant mice.	nac	97-100	early growth response 1	Mus musculus	49-55
23483217-10	2013	The mRNA expression and the levels of MCP-1 and IL-6 in the culture supernatant of the HSCs in this study were elevated by LPS stimulation and inhibited by CGA treatment, as well as NAC and PDTC (a NF-kappaB inhibitor).	nac	182-185	C-C motif chemokine ligand 2	Rattus norvegicus	38-43
23696593-6	2013	Multivariate logistic regression analysis showed that gamma-synuclein was an independent predictor of NAC objective response rate, and a statistically significant relationship was observed between NAC regimen, gamma-synuclein levels and pathological complete response rate.	nac	102-105	synuclein gamma	Homo sapiens	54-69
23696593-7	2013	CONCLUSIONS: These study findings suggest that gamma-synuclein - in combination with other markers such as ER, PR and HER-2 - may serve as a biomarker for response to NAC in breast cancer and warrants further study.	nac	167-170	synuclein gamma	Homo sapiens	47-62
23696593-7	2013	CONCLUSIONS: These study findings suggest that gamma-synuclein - in combination with other markers such as ER, PR and HER-2 - may serve as a biomarker for response to NAC in breast cancer and warrants further study.	nac	167-170	progesterone receptor	Homo sapiens	111-113
23696593-7	2013	CONCLUSIONS: These study findings suggest that gamma-synuclein - in combination with other markers such as ER, PR and HER-2 - may serve as a biomarker for response to NAC in breast cancer and warrants further study.	nac	167-170	erb-b2 receptor tyrosine kinase 2	Homo sapiens	118-123
23658771-7	2013	Pgp and MRP1 were significantly up-regulated after exposure to NAC (Wilcoxon signed-rank p = 0.0024 and p&lt;0.0001), while BCRP showed more variation in response to NAC, with frequent up- (59% of cases) and down-regulation (41%) contributing to a lack of significant difference overall.	nac	63-66	ATP binding cassette subfamily C member 1	Homo sapiens	8-12
23658771-7	2013	Pgp and MRP1 were significantly up-regulated after exposure to NAC (Wilcoxon signed-rank p = 0.0024 and p&lt;0.0001), while BCRP showed more variation in response to NAC, with frequent up- (59% of cases) and down-regulation (41%) contributing to a lack of significant difference overall.	nac	166-169	ATP binding cassette subfamily B member 1	Homo sapiens	0-3
23658771-7	2013	Pgp and MRP1 were significantly up-regulated after exposure to NAC (Wilcoxon signed-rank p = 0.0024 and p&lt;0.0001), while BCRP showed more variation in response to NAC, with frequent up- (59% of cases) and down-regulation (41%) contributing to a lack of significant difference overall.	nac	166-169	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	124-128
23658771-9	2013	Post-NAC expression of BCRP did not correlate with NAC response, but correlated significantly with DFS (Log rank p = 0.007), with longer DFS in patients with low post-NAC BCRP expression.	nac	5-8	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	23-27
23658771-10	2013	In multivariate Cox regression analyses, post-NAC BCRP expression levels proved to predict DFS independently of standard prognostic factors, with high expression associated with a hazard ratio of 4.04 (95% confidence interval 1.3-12.2; p = 0.013).	nac	46-49	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	50-54
23658771-11	2013	We conclude that NAC-induced expression levels of BCRP predict survival after NAC for breast cancer, while Pgp and MRP1 expression have little predictive value.	nac	17-20	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	50-54
23658771-11	2013	We conclude that NAC-induced expression levels of BCRP predict survival after NAC for breast cancer, while Pgp and MRP1 expression have little predictive value.	nac	78-81	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	50-54
23266327-3	2013	Considering that activation of the extracellular signal-regulated protein kinase (ERK) is suggested to be involved in cocaine-induced behavioral sensitization, we study the effects of perinatal protein deprivation on phosphorylated ERK2 (pERK2) protein levels in the NAc (core and shell) during different drug-free withdrawal periods.	nac	267-270	Eph receptor B1	Rattus norvegicus	82-85
23587288-9	2013	We suppose that NAC acts via an at least partial inactivation of vWF resulting in an insufficient sealing of initial endothelial injury leading to more small microbleeds.	nac	16-19	von Willebrand factor	Rattus norvegicus	65-68
23354537-8	2013	Rats that expressed a persistent CPP had elevated levels of p-ERK1, GluA1, and p-Ser845-GluA1 in NAc core, and the latter correlated with CPP expression.	nac	97-100	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	88-93
23630536-8	2013	Further utilization of this approach has identified two NAC (NAM, ATAF1/2 and CUC2)-domain and two MYB-related genes as putative transcriptional switches regulating wall ingrowth deposition in these cells.	nac	56-59	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	61-64
23630536-8	2013	Further utilization of this approach has identified two NAC (NAM, ATAF1/2 and CUC2)-domain and two MYB-related genes as putative transcriptional switches regulating wall ingrowth deposition in these cells.	nac	56-59	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	66-73
23266327-9	2013	In contrast, in the NAc shell, only sensitized D-rats with cocaine 10 mg/kg showed ERK2 activation on WD21.	nac	20-23	mitogen activated protein kinase 1	Rattus norvegicus	83-87
23123734-5	2013	KEY FINDINGS: In fetal NAC tissues, ERRalpha labeling index (LI) in fetal zone (FZ) was significantly higher that that in neocortex (NC), and the differences among age groups for overall mean LI was statistically significant when analyzed according to individual cortical layers.	nac	23-26	estrogen related receptor alpha	Homo sapiens	36-44
23278405-1	2013	The plant-specific NAC (NAM, ATAF1,2, CUC2) transcription factors play significant roles in diverse physiological processes.	nac	19-22	NO APICAL MERISTEM	Solanum lycopersicum	24-27
23252373-5	2013	Coincident with these morphological changes, cpk28 mutants showed altered expression of NAC transcriptional regulators NST1 and NST3 as well as of GA3ox1, a key regulator of gibberellic acid homeostasis.	nac	88-91	calcium-dependent protein kinase 28	Arabidopsis thaliana	45-50
23146027-1	2013	CONCLUSION: ERCC 1 seems to be promising as a predictive marker for response to neoadjuvant chemotherapy (NAC) and early decision for surgery in advanced squamous cell carcinoma (SCC) of the maxillary sinus.	nac	106-109	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	12-18
23146027-2	2013	OBJECTIVES: This study aimed to find a possible relation of ERCC1 or XRCC1 expression with response to NAC and prognosis in advanced SCC of the maxillary sinus.	nac	103-106	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	60-65
23146027-2	2013	OBJECTIVES: This study aimed to find a possible relation of ERCC1 or XRCC1 expression with response to NAC and prognosis in advanced SCC of the maxillary sinus.	nac	103-106	X-ray repair cross complementing 1	Homo sapiens	69-74
23386682-2	2013	This work used an oestradiol-inducible system to overexpress the NAC transcription factor BdSWN5 in the monocot model Brachypodium distachyon.	nac	65-68	protein SOMBRERO	Brachypodium distachyon	90-96
23123734-7	2013	ERRalpha mRNA was detected in NAC and all types of ACT.	nac	30-33	estrogen related receptor alpha	Homo sapiens	0-8
23804139-5	2013	In a comparison between the 9 (5%) sensitive patients and 30 (16%) insensitive patients, overexpression of p53 but not overexpression of either HER2 or EGFR was associated with a good response to NAC.	nac	196-199	tumor protein p53	Homo sapiens	107-110
23320561-12	2013	Percentage of FOXP3+ Tregs in blood predicted the response of the LLABCs to subsequent NAC (p=0.04).	nac	87-90	forkhead box P3	Homo sapiens	14-19
23804139-6	2013	p53 (p=0.045) and histological grade 3 (p=0.011) were important and significant predictors of the response to NAC.	nac	110-113	tumor protein p53	Homo sapiens	0-3
23804139-10	2013	We conclude that the level of p53 expression in the CNB was an effective and reliable predictor of treatment response to NAC.	nac	121-124	tumor protein p53	Homo sapiens	30-33
23406601-7	2013	RESULTS: NAC after PL/PL resulted in increase in symptoms, histamine, and tryptase after the challenge on the 2nd day.	nac	9-12	coiled-coil domain containing 177	Homo sapiens	19-24
23988581-6	2013	Treatment of Caco-2 cell monolayers with N-actylcysteine (NAC), a scavenger of reactive oxygen species (ROS), attenuated toxin-dependent increases in iNOS and HIF-1alpha protein levels but had no effect on FIH-1 responses.	nac	58-61	nitric oxide synthase 2	Homo sapiens	150-154
24335178-2	2013	In this study, we sought to examine the hypothesis that neoadjuvant chemotherapy (NAC) is a better approach with improved prognosis and outcomes after laparoscopical radical hysterectomy (LRH) on patients with cervical cancer and to elucidate the potential roles of the p53:miR-34a:E2F1 and the p53:miR-605:Mdm2 signaling pathways in this therapy.	nac	82-85	tumor protein p53	Homo sapiens	270-273
24335178-2	2013	In this study, we sought to examine the hypothesis that neoadjuvant chemotherapy (NAC) is a better approach with improved prognosis and outcomes after laparoscopical radical hysterectomy (LRH) on patients with cervical cancer and to elucidate the potential roles of the p53:miR-34a:E2F1 and the p53:miR-605:Mdm2 signaling pathways in this therapy.	nac	82-85	microRNA 34a	Homo sapiens	274-281
24335178-2	2013	In this study, we sought to examine the hypothesis that neoadjuvant chemotherapy (NAC) is a better approach with improved prognosis and outcomes after laparoscopical radical hysterectomy (LRH) on patients with cervical cancer and to elucidate the potential roles of the p53:miR-34a:E2F1 and the p53:miR-605:Mdm2 signaling pathways in this therapy.	nac	82-85	E2F transcription factor 1	Homo sapiens	282-286
24335178-2	2013	In this study, we sought to examine the hypothesis that neoadjuvant chemotherapy (NAC) is a better approach with improved prognosis and outcomes after laparoscopical radical hysterectomy (LRH) on patients with cervical cancer and to elucidate the potential roles of the p53:miR-34a:E2F1 and the p53:miR-605:Mdm2 signaling pathways in this therapy.	nac	82-85	tumor protein p53	Homo sapiens	295-298
24335178-2	2013	In this study, we sought to examine the hypothesis that neoadjuvant chemotherapy (NAC) is a better approach with improved prognosis and outcomes after laparoscopical radical hysterectomy (LRH) on patients with cervical cancer and to elucidate the potential roles of the p53:miR-34a:E2F1 and the p53:miR-605:Mdm2 signaling pathways in this therapy.	nac	82-85	microRNA 605	Homo sapiens	299-306
24335178-2	2013	In this study, we sought to examine the hypothesis that neoadjuvant chemotherapy (NAC) is a better approach with improved prognosis and outcomes after laparoscopical radical hysterectomy (LRH) on patients with cervical cancer and to elucidate the potential roles of the p53:miR-34a:E2F1 and the p53:miR-605:Mdm2 signaling pathways in this therapy.	nac	82-85	MDM2 proto-oncogene	Homo sapiens	307-311
24335178-10	2013	Furthermore, molecular biology analyses revealed that the protein and mRNA levels of p53 were both markedly increased in patients who received NAC than those who did not, and oppositely, the levels of E2F1 and Mdm2 were significantly lower in the NAC+LRH patients than in the LRH patients.	nac	143-146	tumor protein p53	Homo sapiens	85-88
24335178-10	2013	Furthermore, molecular biology analyses revealed that the protein and mRNA levels of p53 were both markedly increased in patients who received NAC than those who did not, and oppositely, the levels of E2F1 and Mdm2 were significantly lower in the NAC+LRH patients than in the LRH patients.	nac	143-146	MDM2 proto-oncogene	Homo sapiens	210-214
24335178-10	2013	Furthermore, molecular biology analyses revealed that the protein and mRNA levels of p53 were both markedly increased in patients who received NAC than those who did not, and oppositely, the levels of E2F1 and Mdm2 were significantly lower in the NAC+LRH patients than in the LRH patients.	nac	247-250	tumor protein p53	Homo sapiens	85-88
24335178-10	2013	Furthermore, molecular biology analyses revealed that the protein and mRNA levels of p53 were both markedly increased in patients who received NAC than those who did not, and oppositely, the levels of E2F1 and Mdm2 were significantly lower in the NAC+LRH patients than in the LRH patients.	nac	247-250	E2F transcription factor 1	Homo sapiens	201-205
24335178-10	2013	Furthermore, molecular biology analyses revealed that the protein and mRNA levels of p53 were both markedly increased in patients who received NAC than those who did not, and oppositely, the levels of E2F1 and Mdm2 were significantly lower in the NAC+LRH patients than in the LRH patients.	nac	247-250	MDM2 proto-oncogene	Homo sapiens	210-214
24335178-11	2013	The levels of miR-34a and miR-605 were considerably higher with NAC relative to without NAC.	nac	64-67	microRNA 34a	Homo sapiens	14-21
24335178-11	2013	The levels of miR-34a and miR-605 were considerably higher with NAC relative to without NAC.	nac	64-67	microRNA 605	Homo sapiens	26-33
24335178-11	2013	The levels of miR-34a and miR-605 were considerably higher with NAC relative to without NAC.	nac	88-91	microRNA 34a	Homo sapiens	14-21
24335178-11	2013	The levels of miR-34a and miR-605 were considerably higher with NAC relative to without NAC.	nac	88-91	microRNA 605	Homo sapiens	26-33
24335178-12	2013	Among the three anti-cancer drugs included in NAC, cisplatin was found to be the main component that caused increases in p53 protein levels, miR-34a and miR-605 miRNA levels, and decreases in Mdm2 and E2F1 protein levels.	nac	46-49	MDM2 proto-oncogene	Homo sapiens	192-196
24335178-14	2013	CONCLUSION: These findings not only indicate NAC as a rational approach for better treatment of cervical cancer with improved therapeutic outcomes, due partly to the ability of cisplatin to promote the p53:miR-34a:E2F1 positive feed-forward loop and the p53:miR-605:Mdm2 positive feedback loop.	nac	45-48	tumor protein p53	Homo sapiens	202-205
24335178-14	2013	CONCLUSION: These findings not only indicate NAC as a rational approach for better treatment of cervical cancer with improved therapeutic outcomes, due partly to the ability of cisplatin to promote the p53:miR-34a:E2F1 positive feed-forward loop and the p53:miR-605:Mdm2 positive feedback loop.	nac	45-48	microRNA 34a	Homo sapiens	206-213
24335178-14	2013	CONCLUSION: These findings not only indicate NAC as a rational approach for better treatment of cervical cancer with improved therapeutic outcomes, due partly to the ability of cisplatin to promote the p53:miR-34a:E2F1 positive feed-forward loop and the p53:miR-605:Mdm2 positive feedback loop.	nac	45-48	E2F transcription factor 1	Homo sapiens	214-218
24335178-14	2013	CONCLUSION: These findings not only indicate NAC as a rational approach for better treatment of cervical cancer with improved therapeutic outcomes, due partly to the ability of cisplatin to promote the p53:miR-34a:E2F1 positive feed-forward loop and the p53:miR-605:Mdm2 positive feedback loop.	nac	45-48	tumor protein p53	Homo sapiens	254-257
24335178-14	2013	CONCLUSION: These findings not only indicate NAC as a rational approach for better treatment of cervical cancer with improved therapeutic outcomes, due partly to the ability of cisplatin to promote the p53:miR-34a:E2F1 positive feed-forward loop and the p53:miR-605:Mdm2 positive feedback loop.	nac	45-48	microRNA 605	Homo sapiens	258-265
23053273-6	2013	In the group with tumor responses, we found a statistically significant downregulation of expression of ABCB1, ABCC1, ABCC2, ABCC5, ABCG1, ABCG2, GSTP1, and MVP genes following NAC in FAC and CAX-treated patients (67-93% of cases).	nac	177-180	ATP binding cassette subfamily B member 1	Homo sapiens	104-109
23053273-6	2013	In the group with tumor responses, we found a statistically significant downregulation of expression of ABCB1, ABCC1, ABCC2, ABCC5, ABCG1, ABCG2, GSTP1, and MVP genes following NAC in FAC and CAX-treated patients (67-93% of cases).	nac	177-180	ATP binding cassette subfamily C member 1	Homo sapiens	111-116
23053273-6	2013	In the group with tumor responses, we found a statistically significant downregulation of expression of ABCB1, ABCC1, ABCC2, ABCC5, ABCG1, ABCG2, GSTP1, and MVP genes following NAC in FAC and CAX-treated patients (67-93% of cases).	nac	177-180	ATP binding cassette subfamily C member 2	Homo sapiens	118-123
23053273-6	2013	In the group with tumor responses, we found a statistically significant downregulation of expression of ABCB1, ABCC1, ABCC2, ABCC5, ABCG1, ABCG2, GSTP1, and MVP genes following NAC in FAC and CAX-treated patients (67-93% of cases).	nac	177-180	ATP binding cassette subfamily C member 5	Homo sapiens	125-130
23053273-6	2013	In the group with tumor responses, we found a statistically significant downregulation of expression of ABCB1, ABCC1, ABCC2, ABCC5, ABCG1, ABCG2, GSTP1, and MVP genes following NAC in FAC and CAX-treated patients (67-93% of cases).	nac	177-180	ATP binding cassette subfamily G member 1	Homo sapiens	132-137
23053273-6	2013	In the group with tumor responses, we found a statistically significant downregulation of expression of ABCB1, ABCC1, ABCC2, ABCC5, ABCG1, ABCG2, GSTP1, and MVP genes following NAC in FAC and CAX-treated patients (67-93% of cases).	nac	177-180	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	139-144
23053273-6	2013	In the group with tumor responses, we found a statistically significant downregulation of expression of ABCB1, ABCC1, ABCC2, ABCC5, ABCG1, ABCG2, GSTP1, and MVP genes following NAC in FAC and CAX-treated patients (67-93% of cases).	nac	177-180	glutathione S-transferase pi 1	Homo sapiens	146-151
23053273-6	2013	In the group with tumor responses, we found a statistically significant downregulation of expression of ABCB1, ABCC1, ABCC2, ABCC5, ABCG1, ABCG2, GSTP1, and MVP genes following NAC in FAC and CAX-treated patients (67-93% of cases).	nac	177-180	major vault protein	Homo sapiens	157-160
24335178-14	2013	CONCLUSION: These findings not only indicate NAC as a rational approach for better treatment of cervical cancer with improved therapeutic outcomes, due partly to the ability of cisplatin to promote the p53:miR-34a:E2F1 positive feed-forward loop and the p53:miR-605:Mdm2 positive feedback loop.	nac	45-48	MDM2 proto-oncogene	Homo sapiens	266-270
23988581-6	2013	Treatment of Caco-2 cell monolayers with N-actylcysteine (NAC), a scavenger of reactive oxygen species (ROS), attenuated toxin-dependent increases in iNOS and HIF-1alpha protein levels but had no effect on FIH-1 responses.	nac	58-61	hypoxia inducible factor 1 subunit alpha	Homo sapiens	159-169
23988581-6	2013	Treatment of Caco-2 cell monolayers with N-actylcysteine (NAC), a scavenger of reactive oxygen species (ROS), attenuated toxin-dependent increases in iNOS and HIF-1alpha protein levels but had no effect on FIH-1 responses.	nac	58-61	hypoxia inducible factor 1 subunit alpha inhibitor	Homo sapiens	206-211
23349663-8	2013	AngII-reduced AdipoR1 expression was reversed by pretreatment with NAC, apocynin, gp91 ds-tat, rotenone, and an ERK1/2 inhibitor PD98059.	nac	67-70	angiotensinogen	Rattus norvegicus	0-5
24383004-1	2013	In prognostic studies for breast cancer patients treated with neoadjuvant chemotherapy (NAC), the ordinary Cox proportional-hazards (PH) model has been often used to identify prognostic factors for disease-free survival (DFS).	nac	88-91	cytochrome c oxidase subunit 8A	Homo sapiens	107-110
24383004-7	2013	The purpose of this study was to identify the clinical factors associated with cure and the variables associated with the time to recurrence or death in NAC-treated breast cancer patients without a pathologic complete response, by using the Cox PH cure model.	nac	153-156	cytochrome c oxidase subunit 8A	Homo sapiens	241-244
23349663-8	2013	AngII-reduced AdipoR1 expression was reversed by pretreatment with NAC, apocynin, gp91 ds-tat, rotenone, and an ERK1/2 inhibitor PD98059.	nac	67-70	adiponectin receptor 1	Rattus norvegicus	14-21
23349663-10	2013	Moreover, AngII-induced DNA binding activity of c-Myc was inhibited by losartan, NAC, apocynin, gp91 ds-tat, rotenone, and PD98059.	nac	81-84	angiotensinogen	Rattus norvegicus	10-15
23349663-10	2013	Moreover, AngII-induced DNA binding activity of c-Myc was inhibited by losartan, NAC, apocynin, gp91 ds-tat, rotenone, and PD98059.	nac	81-84	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	48-53
23059796-14	2012	Alternatively, GPI-1046 (10mg/kg) upregulated GLT1 level in NAc-core compared to vehicle (ethanol naive) group.	nac	60-63	solute carrier family 1 member 2	Rattus norvegicus	46-50
22967043-2	2012	NTL6 is a plant-specific NAC [NAM/ATAF1/2/CUC2] transcription factor that is expressed as a dormant plasma membrane-associated form in Arabidopsis.	nac	25-28	NAC domain containing protein 62	Arabidopsis thaliana	0-4
22967043-2	2012	NTL6 is a plant-specific NAC [NAM/ATAF1/2/CUC2] transcription factor that is expressed as a dormant plasma membrane-associated form in Arabidopsis.	nac	25-28	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	34-41
22967043-2	2012	NTL6 is a plant-specific NAC [NAM/ATAF1/2/CUC2] transcription factor that is expressed as a dormant plasma membrane-associated form in Arabidopsis.	nac	25-28	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	42-46
22801866-2	2012	In this study, two genes (BnNAC2 and BnNAC5) encoding the putative NAC transcription factors were identified in Brassica napus.	nac	28-31	NAC domain-containing protein 83	Brassica napus	37-43
22766518-10	2012	INTERPRETATION: This meta-analysis provides evidence of an independent association between breast cancer subtype and pCR; odds of pCR were highest for the triple negative and HER2+/HR- subtypes, with evidence of an influential effect on achieving pCR in the latter subtype through inclusion of HER2-directed therapy with NAC.	nac	321-324	erb-b2 receptor tyrosine kinase 2	Homo sapiens	175-179
23205119-1	2012	The aim of this study was to investigate the correlation between breast cancer-specific gene 1 (BCSG1) and the effect of neoadjuvant chemotherapy (NAC) in patients with triple-negative breast cancer (TNBC).	nac	147-150	synuclein gamma	Homo sapiens	65-94
23205119-1	2012	The aim of this study was to investigate the correlation between breast cancer-specific gene 1 (BCSG1) and the effect of neoadjuvant chemotherapy (NAC) in patients with triple-negative breast cancer (TNBC).	nac	147-150	synuclein gamma	Homo sapiens	96-101
23205119-4	2012	The expression of BCSG1 was also decreased after NAC at both mRNA and protein levels.	nac	49-52	synuclein gamma	Homo sapiens	18-23
23205119-5	2012	There was a negative correlation between BCSG1 levels after NAC and the effect of NAC.	nac	60-63	synuclein gamma	Homo sapiens	41-46
23205119-5	2012	There was a negative correlation between BCSG1 levels after NAC and the effect of NAC.	nac	82-85	synuclein gamma	Homo sapiens	41-46
23205119-6	2012	BCSG1 may be a potential target for NAC in the treatment of TNBC.	nac	36-39	synuclein gamma	Homo sapiens	0-5
22986814-9	2012	FOXP3 infiltrate, in combination with Ki67, could thus be used as a clinically useful predictor of response to NAC.	nac	111-114	forkhead box P3	Homo sapiens	0-5
22471939-8	2012	Likewise, T (CD3), B (CD19), and NK (CD56/CD16) cells were detected in the NAC fraction.	nac	75-78	CD19 molecule	Homo sapiens	22-26
22471939-8	2012	Likewise, T (CD3), B (CD19), and NK (CD56/CD16) cells were detected in the NAC fraction.	nac	75-78	neural cell adhesion molecule 1	Homo sapiens	37-41
22471939-8	2012	Likewise, T (CD3), B (CD19), and NK (CD56/CD16) cells were detected in the NAC fraction.	nac	75-78	Fc gamma receptor IIIa	Homo sapiens	42-46
22895544-8	2012	In addition, we found that similar to the effect of NaHS, pretreatment with NAC (a ROS scavenger) or U0126 (a MEK1/2 inhibitor) blocked the downregulation of GLT-1 expression induced by CoCl2.	nac	76-79	mitogen activated protein kinase kinase 1	Rattus norvegicus	110-116
22895544-8	2012	In addition, we found that similar to the effect of NaHS, pretreatment with NAC (a ROS scavenger) or U0126 (a MEK1/2 inhibitor) blocked the downregulation of GLT-1 expression induced by CoCl2.	nac	76-79	solute carrier family 1 member 2	Rattus norvegicus	158-163
22207705-8	2012	Various  mediators are known to affect the function of the NAC smooth muscles; however,  this study demonstrates that enzymes (eNOS and nNOS) that synthesize nitric  oxide are expressed in the NAC.	nac	59-62	nitric oxide synthase 1	Homo sapiens	136-140
23023382-6	2012	RESULTS: BSO and NAC significantly decreased IL-6 and TNF-alpha levels at 14 days of differentiation, whereas, NAC decreased the levels of IL-8 at days 2 and 14 of differentiation.	nac	17-20	interleukin 6	Homo sapiens	45-49
23023382-6	2012	RESULTS: BSO and NAC significantly decreased IL-6 and TNF-alpha levels at 14 days of differentiation, whereas, NAC decreased the levels of IL-8 at days 2 and 14 of differentiation.	nac	17-20	tumor necrosis factor	Homo sapiens	54-63
23023382-6	2012	RESULTS: BSO and NAC significantly decreased IL-6 and TNF-alpha levels at 14 days of differentiation, whereas, NAC decreased the levels of IL-8 at days 2 and 14 of differentiation.	nac	111-114	C-X-C motif chemokine ligand 8	Homo sapiens	139-143
23373221-4	2012	Both colorimetry and immunohistochemistry methods were adopted to detect the content of glutamate neurotransmitter in each brain region and the expression of NR2B in VTA-NAc-PFC neuroanatomical circuit.	nac	170-173	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	158-162
22499859-6	2012	The decrease of SUV after the first course of NAC (DeltaSUV) was significantly higher in TN and HER2-positive subtypes (-45% +- 25% and -57% +- 30%, respectively) than in luminal one (-19% +- 35%; P &lt; 0.0001).	nac	46-49	erb-b2 receptor tyrosine kinase 2	Homo sapiens	96-100
22809665-5	2012	Our findings were that Nac protected against LPS-induced Abeta transport dysfunction at the BBB through an LRP-1-dependent and Pgp-independent mechanism.	nac	23-26	LDL receptor related protein 1	Homo sapiens	107-112
22809665-5	2012	Our findings were that Nac protected against LPS-induced Abeta transport dysfunction at the BBB through an LRP-1-dependent and Pgp-independent mechanism.	nac	23-26	ATP binding cassette subfamily B member 1	Homo sapiens	127-130
22809665-7	2012	We also found that Nac pre-administration resulted in lower blood levels of the cytokines and chemokines interferon-gamma, interleukin-10, CCL2, CCL4, and CCL5, but only lowered CCL4 in the cerebral cortex and hippocampus.	nac	19-22	interferon gamma	Homo sapiens	105-121
22809665-7	2012	We also found that Nac pre-administration resulted in lower blood levels of the cytokines and chemokines interferon-gamma, interleukin-10, CCL2, CCL4, and CCL5, but only lowered CCL4 in the cerebral cortex and hippocampus.	nac	19-22	interleukin 10	Homo sapiens	123-137
22809665-7	2012	We also found that Nac pre-administration resulted in lower blood levels of the cytokines and chemokines interferon-gamma, interleukin-10, CCL2, CCL4, and CCL5, but only lowered CCL4 in the cerebral cortex and hippocampus.	nac	19-22	C-C motif chemokine ligand 2	Homo sapiens	139-143
22809665-7	2012	We also found that Nac pre-administration resulted in lower blood levels of the cytokines and chemokines interferon-gamma, interleukin-10, CCL2, CCL4, and CCL5, but only lowered CCL4 in the cerebral cortex and hippocampus.	nac	19-22	C-C motif chemokine ligand 4	Homo sapiens	145-149
22809665-7	2012	We also found that Nac pre-administration resulted in lower blood levels of the cytokines and chemokines interferon-gamma, interleukin-10, CCL2, CCL4, and CCL5, but only lowered CCL4 in the cerebral cortex and hippocampus.	nac	19-22	C-C motif chemokine ligand 5	Homo sapiens	155-159
22809665-7	2012	We also found that Nac pre-administration resulted in lower blood levels of the cytokines and chemokines interferon-gamma, interleukin-10, CCL2, CCL4, and CCL5, but only lowered CCL4 in the cerebral cortex and hippocampus.	nac	19-22	C-C motif chemokine ligand 4	Homo sapiens	178-182
22771975-3	2012	Entrapping pep2-SVKI, a peptide known to compete for the binding of GluA2 subunit to scaffolding proteins involved in AMPA receptor endocytosis, in NAC synaptosomes prevented the nicotine-induced reduction of AMPA-mediated [3H]DA exocytosis, while pep2-SVKE, used as negative control, was inefficacious.	nac	148-151	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	68-73
22207705-8	2012	Various  mediators are known to affect the function of the NAC smooth muscles; however,  this study demonstrates that enzymes (eNOS and nNOS) that synthesize nitric  oxide are expressed in the NAC.	nac	193-196	nitric oxide synthase 1	Homo sapiens	136-140
22180194-5	2012	RESULTS: The presence of ALDH1-positive cancer cells, but not ALDH1-negative cancer cells, in primary and metastatic lesions after NAC was associated with a worse prognosis.	nac	131-134	aldehyde dehydrogenase 1 family member A1	Homo sapiens	25-30
23023171-5	2012	The observed de novo xylem formation correlates with Verticillium-induced expression of the VASCULAR-RELATED NAC DOMAIN (VND) transcription factor gene VND7.	nac	109-112	vascular related NAC-domain protein 7	Arabidopsis thaliana	152-156
22180194-6	2012	In multivariate analysis, only ALDH1-positive cells in metastatic lesions after NAC correlated with overall survival.	nac	80-83	aldehyde dehydrogenase 1 family member A1	Homo sapiens	31-36
22180194-7	2012	The responsiveness of ALDH1-positive cells to chemotherapy differed between primary and metastatic lesions, and the findings indicated that ALDH1-positive cells in metastatic lesions after NAC may clinically precede those in the primary lesion.	nac	189-192	aldehyde dehydrogenase 1 family member A1	Homo sapiens	140-145
22706448-4	2012	Exposure of saul1 mutants to low light for only 24 h did not result in visible symptoms of senescence; however, the senescence-promoting transcription factor genes WRKY53, WRKY6, and NAC-LIKE ACTIVATED BY AP3/PI were up-regulated, indicating that senescence in saul1 seedlings was already initiated.	nac	183-186	senescence-associated E3 ubiquitin ligase 1	Arabidopsis thaliana	12-17
22634539-1	2012	Changes in magnetic resonance imaging (MRI) during neoadjuvant chemotherapy (NAC) have been reported as predictive of pathology outcome in triple-negative and HER2-positive breast cancer.	nac	77-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	159-163
22754717-3	2012	We analyzed the expression of MMPs and their inhibitors, tissue inhibitors of metalloproteinases (TIMPs), in allergic nasal mucosa after nasal allergen challenge (NAC) and determined their relationship to inflammatory cells.	nac	163-166	matrix metallopeptidase 2	Homo sapiens	30-34
22754717-10	2012	At 12 hours post-NAC, the number of MMP-13+ cells tended to be higher in HDM-exposed mucosa and was strongly correlated with the number of eosinophils.	nac	17-20	matrix metallopeptidase 13	Homo sapiens	36-42
22683778-5	2012	Low concentrations of dual specificity protein phosphatase 4 (DUSP4), an ERK phosphatase, correlated with high post-NAC tumor cell proliferation and with basal-like breast cancer (BLBC) status.	nac	116-119	dual specificity phosphatase 4	Homo sapiens	22-60
22683778-5	2012	Low concentrations of dual specificity protein phosphatase 4 (DUSP4), an ERK phosphatase, correlated with high post-NAC tumor cell proliferation and with basal-like breast cancer (BLBC) status.	nac	116-119	dual specificity phosphatase 4	Homo sapiens	62-67
22683778-5	2012	Low concentrations of dual specificity protein phosphatase 4 (DUSP4), an ERK phosphatase, correlated with high post-NAC tumor cell proliferation and with basal-like breast cancer (BLBC) status.	nac	116-119	mitogen-activated protein kinase 1	Homo sapiens	73-76
22683778-8	2012	Reduced DUSP4 expression in primary tumors after NAC was associated with treatment-refractory high Ki-67 scores and shorter recurrence-free survival.	nac	49-52	dual specificity phosphatase 4	Homo sapiens	8-13
21909982-2	2012	Several prognostic markers, including estrogen receptor-alpha (ERalpha), are used to predict the response to NAC.	nac	109-112	estrogen receptor 1	Homo sapiens	38-61
21909982-2	2012	Several prognostic markers, including estrogen receptor-alpha (ERalpha), are used to predict the response to NAC.	nac	109-112	estrogen receptor 1	Homo sapiens	63-70
21909982-4	2012	To examine this issue, we first evaluated ERalpha transcriptional activity in breast cancer cells derived from pre-NAC specimens using estrogen response element-green fluorescent protein (ERE-GFP) as a reporter gene, and found that, in the cases for which ERalpha activities determined by GFP expression were not detected or low, pCR (pathological complete response) could be achieved even though ERalpha protein was expressed.	nac	115-118	estrogen receptor 1	Homo sapiens	42-49
21909982-9	2012	Taken together, these results suggest that ERalpha expression directly regulates sensitivity to paclitaxel in NAC for breast cancer via the effect on microtubule stability.	nac	110-113	estrogen receptor 1	Homo sapiens	43-50
22006374-8	2012	NAC involvement was most significantly associated with tumors located in all four quadrants (P&lt;0.0001), tumors&gt;5 cm in size (P=0.0014 for invasive carcinoma and P=0.0032 for in-situ carcinoma), grade 3 tumors (P=0.0192), tumors with higher nuclear grades (P=0.0184), and tumors with HER2 overexpression (P=0.0137).	nac	0-3	erb-b2 receptor tyrosine kinase 2	Homo sapiens	289-293
22783415-4	2012	The expression frequencies of M30 and CD44 were significantly higher in the NAC group (61.5 and 53.8%) compared to the control group (9.5 and 14.3%); however, no significant difference in Snail expression was noted between the two groups (53.8 versus 42.9%).	nac	76-79	CD44 molecule (Indian blood group)	Homo sapiens	38-42
22274962-7	2012	It is concluded that the amyloidogenic NAC region (residues 61-95) contains the chaperone-binding site which is optimized for target protein binding as a result of its beta-sheet formation and/or ordered aggregation by alpha-synuclein.	nac	39-42	synuclein alpha	Homo sapiens	219-234
22006374-9	2012	CONCLUSIONS: On the basis of our findings, we have developed a mathematical model that is based on the extent and location of the tumor, HER2 expression, and nuclear grade that predicts the probability of NAC involvement by breast cancer.	nac	205-208	erb-b2 receptor tyrosine kinase 2	Homo sapiens	137-141
21981750-5	2012	In contrast, ABO alloantibodies required a minimum trisaccharide Gal(NAc)alpha1-3(Fucalpha1-2)Gal epitope and recognize the elongated type-specific tetrasaccharides.	nac	69-72	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	13-16
22082019-2	2012	We show here that six new genes encoding NAC TFs in wheat (Triticum aestivum) were identified (named as TaNAC2a, TaNAC4a, TaNAC6, TaNAC7, TaNAC13 and TaNTL5, respectively), and we classified them into three groups: stress-related NACs, development-related NACs and NTLs (membrane-associated TFs belonging to NAC) by phylogenetic analysis.	nac	41-44	NAC domain-containing protein 2	Triticum aestivum	104-111
22082019-2	2012	We show here that six new genes encoding NAC TFs in wheat (Triticum aestivum) were identified (named as TaNAC2a, TaNAC4a, TaNAC6, TaNAC7, TaNAC13 and TaNTL5, respectively), and we classified them into three groups: stress-related NACs, development-related NACs and NTLs (membrane-associated TFs belonging to NAC) by phylogenetic analysis.	nac	41-44	NAC domain-containing protein 48	Triticum aestivum	122-128
22082019-2	2012	We show here that six new genes encoding NAC TFs in wheat (Triticum aestivum) were identified (named as TaNAC2a, TaNAC4a, TaNAC6, TaNAC7, TaNAC13 and TaNTL5, respectively), and we classified them into three groups: stress-related NACs, development-related NACs and NTLs (membrane-associated TFs belonging to NAC) by phylogenetic analysis.	nac	41-44	NAC domain-containing protein 21/22	Triticum aestivum	130-136
22082019-2	2012	We show here that six new genes encoding NAC TFs in wheat (Triticum aestivum) were identified (named as TaNAC2a, TaNAC4a, TaNAC6, TaNAC7, TaNAC13 and TaNTL5, respectively), and we classified them into three groups: stress-related NACs, development-related NACs and NTLs (membrane-associated TFs belonging to NAC) by phylogenetic analysis.	nac	41-44	NAC domain-containing protein 78	Triticum aestivum	150-156
22082019-2	2012	We show here that six new genes encoding NAC TFs in wheat (Triticum aestivum) were identified (named as TaNAC2a, TaNAC4a, TaNAC6, TaNAC7, TaNAC13 and TaNTL5, respectively), and we classified them into three groups: stress-related NACs, development-related NACs and NTLs (membrane-associated TFs belonging to NAC) by phylogenetic analysis.	nac	106-109	NAC domain-containing protein 78	Triticum aestivum	150-156
21637957-1	2012	NAC (for NAM, ATAF1, 2, and CUC2) family genes have been found to play an important role in diversified developmental processes and environmental responses.	nac	0-3	NO APICAL MERISTEM	Solanum lycopersicum	9-12
22969893-4	2012	Therefore, the aim of the present study was to examine whether the expression of MAD2 is related to the efficacy of NAC for locally advanced uterine cervical cancer.	nac	116-119	mitotic arrest deficient 2 like 1	Homo sapiens	81-85
22969893-10	2012	The results showed that MAD2 expression was significantly higher in the NAC+R group compared to the NAC+OP+R group (P&lt;0.001).	nac	72-75	mitotic arrest deficient 2 like 1	Homo sapiens	24-28
22969893-10	2012	The results showed that MAD2 expression was significantly higher in the NAC+R group compared to the NAC+OP+R group (P&lt;0.001).	nac	100-103	mitotic arrest deficient 2 like 1	Homo sapiens	24-28
22969893-12	2012	Taken together, these results suggest that the expression of MAD2 may predict the efficacy of NAC as a treatment for locally advanced uterine cervical cancer.	nac	94-97	mitotic arrest deficient 2 like 1	Homo sapiens	61-65
21637957-4	2012	A plant-specific and conserved NAC domain is located in the N-terminus of SlNAC3.	nac	31-34	NAC domain transcription factor	Solanum lycopersicum	74-80
23220853-5	2012	TGF-betaRII protein expression was evaluated using immunohistochemistry on a tissue microarray containing 110 TNM stage III BC samples obtained prior to doxorubicin-based neoadjuvant chemotherapy (NAC).	nac	197-200	transforming growth factor beta receptor 2	Homo sapiens	0-11
22197883-6	2012	Genome-wide analysis of direct targets of MYB46 demonstrated that it directly regulates the expression of not only a number of downstream transcription factors, but also a suite of secondary wall biosynthetic genes, some of which are also directly activated by secondary wall NAC (SWN) master switches or by MYB46 direct targets.	nac	276-279	myb domain protein 46	Arabidopsis thaliana	42-47
22197883-6	2012	Genome-wide analysis of direct targets of MYB46 demonstrated that it directly regulates the expression of not only a number of downstream transcription factors, but also a suite of secondary wall biosynthetic genes, some of which are also directly activated by secondary wall NAC (SWN) master switches or by MYB46 direct targets.	nac	276-279	myb domain protein 46	Arabidopsis thaliana	308-313
23507670-1	2012	BACKGROUND: For locally advanced breast cancer, neoadjuvant chemotherapy (NAC) is the standard of care for downstaging the tumor prior to surgery, and improved prognoses that are associated with pathological complete responses (pCR) have been noted, particularly in patients with human epidermal growth factor receptor 2 (HER2)-positive and triple negative (TN) tumors.	nac	74-77	erb-b2 receptor tyrosine kinase 2	Homo sapiens	286-320
23507670-1	2012	BACKGROUND: For locally advanced breast cancer, neoadjuvant chemotherapy (NAC) is the standard of care for downstaging the tumor prior to surgery, and improved prognoses that are associated with pathological complete responses (pCR) have been noted, particularly in patients with human epidermal growth factor receptor 2 (HER2)-positive and triple negative (TN) tumors.	nac	74-77	erb-b2 receptor tyrosine kinase 2	Homo sapiens	322-326
22561335-5	2012	Although HER-2 status, assessed by either HER-2/CEP-17 ratio-based FISH or copy number-based FISH, was a predictor of NAC sensitivity, ratio-assessed HER-2 status had a poorer performance in determining patients" responsiveness to NAC (p = .029).	nac	118-121	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-14
22561335-9	2012	CONCLUSION: It is likely that HER-2 copy number but not the HER-2/CEP-17 ratio determines NAC sensitivity.	nac	90-93	erb-b2 receptor tyrosine kinase 2	Homo sapiens	30-35
23185589-7	2012	In sham-operated rats, FosB/DeltaFosB was induced after chronic morphine administration in all the brain stress areas investigated: nucleus accumbens(shell) (NAc), bed nucleus of the stria terminalis (BNST), central amygdala (CeA), hypothalamic paraventricular nucleus (PVN) and nucleus of the solitary tract noradrenergic cell group (NTS-A(2)).	nac	158-161	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-27
23185589-8	2012	Adrenalectomy attenuated the increased production of FosB/DeltaFosB observed after chronic morphine exposure in NAc, CeA, and NTS.	nac	112-115	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	53-57
23049880-12	2012	The number of patients with CD133-positive tumors (62%) after NAC was higher than that (46%) before NAC.	nac	62-65	prominin 1	Homo sapiens	28-33
23049880-12	2012	The number of patients with CD133-positive tumors (62%) after NAC was higher than that (46%) before NAC.	nac	100-103	prominin 1	Homo sapiens	28-33
23049880-13	2012	Furthermore, most patients with CD133-positive tumors before NAC maintained the same status after NAC.	nac	61-64	prominin 1	Homo sapiens	32-37
23049880-13	2012	Furthermore, most patients with CD133-positive tumors before NAC maintained the same status after NAC.	nac	98-101	prominin 1	Homo sapiens	32-37
23049880-14	2012	CONCLUSION/SIGNIFICANCE: CD133 before NAC might be a useful marker for predicting the effectiveness of NAC and recurrence of breast cancer after NAC.	nac	103-106	prominin 1	Homo sapiens	25-30
23049880-14	2012	CONCLUSION/SIGNIFICANCE: CD133 before NAC might be a useful marker for predicting the effectiveness of NAC and recurrence of breast cancer after NAC.	nac	103-106	prominin 1	Homo sapiens	25-30
23028505-7	2012	We show that ICP0 provokes the disappearance from centromeres, and the proteasomal degradation of several CENPs from the NAC (CENP-A nucleosome associated) and CAD (CENP-A Distal) complexes.	nac	121-124	aconitate decarboxylase 1	Homo sapiens	126-163
22242182-7	2012	After inhibition of aromatic acid decarboxylase, L-DOPA tissue content per recovered TH protein was greatest in NAc, matched by differences in ser31, but not ser40, phosphorylation.	nac	112-115	tyrosine hydroxylase	Rattus norvegicus	85-87
22479379-8	2012	In parallel, aTUB and UBC were used singly or in combination as reference genes to examine the expression levels of NAC (a homolog of AtNAC2) in plants subjected to various treatments with qRT-PCR.	nac	116-119	NAC domain containing protein 2	Arabidopsis thaliana	134-140
22063193-6	2011	NAC, alpha-lipoic acid and tempol attenuated high pacing frequency-induced ANP secretion but apocynin did not.	nac	0-3	natriuretic peptide A	Rattus norvegicus	75-78
22133261-2	2011	NAC family member SND2 is an indirect target of a principal regulator of fibre secondary cell wall formation, SND1.	nac	0-3	NAC domain containing protein 73	Arabidopsis thaliana	18-22
22133261-2	2011	NAC family member SND2 is an indirect target of a principal regulator of fibre secondary cell wall formation, SND1.	nac	0-3	NAC domain containing protein 12	Arabidopsis thaliana	110-114
21985244-4	2011	In this in vitro study, we found that: (a) alpha-SN directly stimulates the phosphorylation of tau by glycogen synthase kinase-3beta (GSK-3beta), (b) alpha-SN forms a heterotrimeric complex with tau and GSK-3beta, and (c) the nonamyloid beta component (NAC) domain and an acidic region of alpha-SN are responsible for the stimulation of GSK-3beta-mediated tau phosphorylation.	nac	253-256	synuclein, alpha	Mus musculus	43-51
21985244-4	2011	In this in vitro study, we found that: (a) alpha-SN directly stimulates the phosphorylation of tau by glycogen synthase kinase-3beta (GSK-3beta), (b) alpha-SN forms a heterotrimeric complex with tau and GSK-3beta, and (c) the nonamyloid beta component (NAC) domain and an acidic region of alpha-SN are responsible for the stimulation of GSK-3beta-mediated tau phosphorylation.	nac	253-256	glycogen synthase kinase 3 beta	Mus musculus	134-143
22063193-10	2011	NAC and apocynin reduced high pacing frequency-induced ANP secretion in diabetic rat atria.	nac	0-3	natriuretic peptide A	Rattus norvegicus	55-58
21975078-7	2011	We then applied the approach to the analysis of glycosylation patterns of two glycoproteins, which are highly expressed in prostate cancer in our prior studies, prostate specific antigen (PSA) and membrane metallo-endopeptidase (MME), from aggressive (AC) and nonaggressive prostate cancer (NAC) tissues.	nac	291-294	membrane metalloendopeptidase	Homo sapiens	229-232
21883551-6	2011	Furthermore, trans-activation assays show that the expression of SND1 operates under positive feedback control from itself, and SND1 was shown to bind directly to a conserved motif in its own promoter, located within a recently described 19-bp secondary wall NAC binding element.	nac	259-262	NAC domain containing protein 12	Arabidopsis thaliana	65-69
21883551-6	2011	Furthermore, trans-activation assays show that the expression of SND1 operates under positive feedback control from itself, and SND1 was shown to bind directly to a conserved motif in its own promoter, located within a recently described 19-bp secondary wall NAC binding element.	nac	259-262	NAC domain containing protein 12	Arabidopsis thaliana	128-132
21883551-8	2011	Our results identify a conserved amino acid critical for NST1/SND1 function, and show that the expression of the NAC master switch itself is under both positive (autoregulatory) and negative control.	nac	113-116	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	57-61
21883551-8	2011	Our results identify a conserved amino acid critical for NST1/SND1 function, and show that the expression of the NAC master switch itself is under both positive (autoregulatory) and negative control.	nac	113-116	NAC domain containing protein 12	Arabidopsis thaliana	62-66
21996968-2	2011	Neoadjuvant chemotherapy (NAC) with docetaxel, cisplatin and S-1 was attempted.	nac	26-29	proteasome 26S subunit, non-ATPase 1	Homo sapiens	61-64
22033904-1	2011	To gain  insight into stress-responsive gene regulation in soybean plants, we identified  consensus sequences that could categorize the transcription factors MYBJ7,  BZIP50, C2H2, and NAC2 as members of the gene families myb, bzip, c2h2, and nac, respectively.	nac	242-245	bZIP transcription factor bZIP50	Glycine max	166-172
22033904-1	2011	To gain  insight into stress-responsive gene regulation in soybean plants, we identified  consensus sequences that could categorize the transcription factors MYBJ7,  BZIP50, C2H2, and NAC2 as members of the gene families myb, bzip, c2h2, and nac, respectively.	nac	242-245	NAC domain protein NAC2	Glycine max	184-188
22033904-1	2011	To gain  insight into stress-responsive gene regulation in soybean plants, we identified  consensus sequences that could categorize the transcription factors MYBJ7,  BZIP50, C2H2, and NAC2 as members of the gene families myb, bzip, c2h2, and nac, respectively.	nac	242-245	transcription factor MYB1	Glycine max	221-224
22033904-8	2011	Based on  the phylogenetic trees, it was found that the myb, bzip and nac genes are closely related to myb78, bzip48 and nac2 of  soybean and that c2h2 is closely related to c2h2 of Brassica  napus.	nac	70-73	transcription factor MYB1	Glycine max	56-59
22033904-8	2011	Based on  the phylogenetic trees, it was found that the myb, bzip and nac genes are closely related to myb78, bzip48 and nac2 of  soybean and that c2h2 is closely related to c2h2 of Brassica  napus.	nac	70-73	transcription factor RAX2	Glycine max	103-108
22033904-8	2011	Based on  the phylogenetic trees, it was found that the myb, bzip and nac genes are closely related to myb78, bzip48 and nac2 of  soybean and that c2h2 is closely related to c2h2 of Brassica  napus.	nac	70-73	bZIP transcription factor 48	Glycine max	110-116
22033904-8	2011	Based on  the phylogenetic trees, it was found that the myb, bzip and nac genes are closely related to myb78, bzip48 and nac2 of  soybean and that c2h2 is closely related to c2h2 of Brassica  napus.	nac	70-73	NAC domain protein NAC2	Glycine max	121-125
21947588-12	2011	CONCLUSIONS: The probability of nipple involvement by premalignant or malignant lesions in the NAC of BRCA mutation carriers is low at time of prophylactic mastectomy, but higher (10%) in women undergoing therapeutic mastectomy.	nac	95-98	BRCA1 DNA repair associated	Homo sapiens	102-106
21779911-6	2011	ROS scavenger NAC, caffeine and an ATM-specific inhibitor significantly reduced ARV S1133- and sigmaC-induced DNA breaks, DDIT-3 and GADD45alpha expression, H2AX phosphorylation, and apoptosis.	nac	14-17	DNA damage inducible transcript 3	Gallus gallus	122-128
21779911-6	2011	ROS scavenger NAC, caffeine and an ATM-specific inhibitor significantly reduced ARV S1133- and sigmaC-induced DNA breaks, DDIT-3 and GADD45alpha expression, H2AX phosphorylation, and apoptosis.	nac	14-17	growth arrest and DNA damage inducible alpha	Gallus gallus	133-144
21177040-3	2011	A review of the literature (PubMed search) revealed 32 relevant studies that investigated the concordance of the hormone receptors (ER and/or PR) and HER2 after NAC with or without trastuzumab.	nac	161-164	erb-b2 receptor tyrosine kinase 2	Homo sapiens	150-154
21177040-8	2011	A switch to a negative HER2 receptor in up to 43% of the patients was reported when NAC was combined with trastuzumab.	nac	84-87	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
21966548-2	2011	Here we use immunohistochemistry to evaluate the expression of Slit2 in normal donor prostate (NDP), benign prostatic hyperplasia (BPH), high-grade prostatic intraepithelial neoplasia (HGPIN), normal tissue adjacent to prostatic adenocarcinoma (NAC), primary prostatic adenocarcinoma (PCa), and metastatic prostatic adenocarcinoma (Mets).	nac	245-248	slit guidance ligand 2	Homo sapiens	63-68
21769435-10	2011	Of note, both the expression and up-regulation of a single gene, i.e. HER4, predicted the response to NAC in 26/32 (81%; P=0.002) and in 23/25 (92%; P&lt;0.001) patients, respectively.	nac	102-105	erb-b2 receptor tyrosine kinase 4	Homo sapiens	70-74
21769435-11	2011	These preliminary data indicate that therapy-induced HER4 gene up-regulation may be associated with response to NAC with epirubicine, cyclophosphamide and docetaxel.	nac	112-115	erb-b2 receptor tyrosine kinase 4	Homo sapiens	53-57
21703102-1	2011	The aim of this study was to assess the impact of a single nasal allergen challenge (NAC) on levels of eotaxin and IL-8 and the inflammatory cells in upper and lower airways of allergic rhinitis (AR) patients.	nac	85-88	C-C motif chemokine ligand 11	Homo sapiens	103-110
21549764-6	2011	injection of morphine (10mg/kg) increased Arc/Arg3.1 protein levels after 2h in the NAc core but not in the NAc shell.	nac	84-87	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	42-52
21549764-7	2011	(2) In CPP experiments, Arc/Arg3.1 protein was increased in the NAc shell of rats following both morphine conditioning and the CPP expression test compared to rats that received the conditioning without the test or those that did not receive morphine conditioning.	nac	64-67	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	24-34
21549764-8	2011	(3) Microinjection of Arc/Arg3.1 antisense oligodeoxynucleotide (AS) into the NAc core inhibited the acquisition, expression and reinstatement of morphine CPP; however, intra-NAc shell infusions of the AS only blocked the expression of CPP.	nac	78-81	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	22-32
21549764-8	2011	(3) Microinjection of Arc/Arg3.1 antisense oligodeoxynucleotide (AS) into the NAc core inhibited the acquisition, expression and reinstatement of morphine CPP; however, intra-NAc shell infusions of the AS only blocked the expression of CPP.	nac	175-178	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	22-32
21549764-9	2011	These findings suggest that expression of the Arc/Arg3.1 protein in the NAc core is required for the acquisition, context-induced retrieval and reinstatement of morphine-associated reward memory, whereas Arc/Arg3.1 protein expression in the NAc shell is only critical for the context-induced retrieval of memory.	nac	72-75	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	46-56
21549764-9	2011	These findings suggest that expression of the Arc/Arg3.1 protein in the NAc core is required for the acquisition, context-induced retrieval and reinstatement of morphine-associated reward memory, whereas Arc/Arg3.1 protein expression in the NAc shell is only critical for the context-induced retrieval of memory.	nac	241-244	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	204-214
21868556-3	2011	The purpose of this study was to determine the clinical and pathological efficacy of neoadjuvant chemotherapy (NAC), using trastuzumab and chemotherapy, with or without anthracyclines, for patients with primary breast cancer and human epidermal growth factor receptor 2 (HER2-)-positive tumors.	nac	111-114	erb-b2 receptor tyrosine kinase 2	Homo sapiens	235-269
21868556-3	2011	The purpose of this study was to determine the clinical and pathological efficacy of neoadjuvant chemotherapy (NAC), using trastuzumab and chemotherapy, with or without anthracyclines, for patients with primary breast cancer and human epidermal growth factor receptor 2 (HER2-)-positive tumors.	nac	111-114	erb-b2 receptor tyrosine kinase 2	Homo sapiens	271-275
21401619-3	2011	Sequence analysis revealed that BeNAC1 belongs to the NAP (NAC-like, activated by APETALA 3/PISTILLATA) subgroup and has a conserved NAC domain in the N-terminus.	nac	34-37	NAC-like, activated by AP3/PI	Arabidopsis thaliana	54-57
21401619-3	2011	Sequence analysis revealed that BeNAC1 belongs to the NAP (NAC-like, activated by APETALA 3/PISTILLATA) subgroup and has a conserved NAC domain in the N-terminus.	nac	59-62	NAC-like, activated by AP3/PI	Arabidopsis thaliana	54-57
20803207-9	2011	CONCLUSIONS: CA-125 regression rate during pre-operative NAC is of independent prognostic value.	nac	57-60	mucin 16, cell surface associated	Homo sapiens	13-19
22088373-1	2011	OBJECTIVE: To investigate the relationship between the pathologic responses and histologic type, grade, the expression of ER, PR and HER2 and their changes in breast carcinoma before and after neoadjuvant chemotherapy (NAC).	nac	219-222	erb-b2 receptor tyrosine kinase 2	Homo sapiens	133-137
22088373-5	2011	RESULTS: (1) Pathologic responses to the NAC were graded as MP1 (14 cases), MP2 (35 cases), MP3 (106 cases), MP4 (36 cases) and MP5 (18 cases); (2) The expression of ER in core needle biopsy had related negatively to the pathologic response (chi2 = 33.083, P = 0.001).	nac	41-44	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	Homo sapiens	60-63
22088373-11	2011	The pathologic appearance, grade, ER, PR and HER2 in breast carcinoma may change after NAC.	nac	87-90	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-49
22088373-12	2011	It is necessary to examine the histologic type, grade and the expression of ER, PR and HER2 after NAC once more.	nac	98-101	erb-b2 receptor tyrosine kinase 2	Homo sapiens	87-91
21561400-6	2011	In P-gp inhibition studies, 0.5% (m/v) chitosan-NAC showed the highest inhibitory effect on P-gp, where the Papp was determined to be 3.78-fold increased compared with the buffer control.	nac	48-51	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	3-7
21561400-6	2011	In P-gp inhibition studies, 0.5% (m/v) chitosan-NAC showed the highest inhibitory effect on P-gp, where the Papp was determined to be 3.78-fold increased compared with the buffer control.	nac	48-51	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	92-96
21561400-7	2011	Among these thiolated chitosans, chitosan-NAC and chitosan-6MNA are the most effective polymers being responsible for P-gp inhibition and permeation enhancement, respectively.	nac	42-45	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	118-122
21602321-1	2011	The nucleus accumbens shell (NAC) receives axons containing dopamine-beta-hydroxylase that originate from brainstem neurons in the nucleus of the solitary tract (NTS).	nac	29-32	dopamine beta-hydroxylase	Rattus norvegicus	60-85
21567078-3	2011	HBX also increased ROS, but reduction of the abundance of ROS using N-acetylcystein (NAC) diminished the levels of Foxo4.	nac	85-88	forkhead box O4	Homo sapiens	115-120
21703102-1	2011	The aim of this study was to assess the impact of a single nasal allergen challenge (NAC) on levels of eotaxin and IL-8 and the inflammatory cells in upper and lower airways of allergic rhinitis (AR) patients.	nac	85-88	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
21703102-6	2011	NAC in AR subjects was associated with significantly increased sputum (p = 0.008) and NLF (p &lt; 0.001) eotaxin levels.	nac	0-3	C-C motif chemokine ligand 11	Homo sapiens	105-112
21703102-7	2011	Post-NAC IL-8 levels were significantly increased in NLF (p &lt; 00001) but not in sputum (p = 0.080) of AR subjects.	nac	5-8	C-X-C motif chemokine ligand 8	Homo sapiens	9-13
21703102-10	2011	NAC is associated with the increased levels of eotaxin in lower airways of AR subjects.	nac	0-3	C-C motif chemokine ligand 11	Homo sapiens	47-54
21508407-2	2011	In our previous study, biological markers such as estrogen receptor (ER), progesterone receptor (PgR), and HER2 were essential predictors of the effectiveness of NAC to help individualize treatment.	nac	162-165	progesterone receptor	Homo sapiens	74-95
21284754-5	2011	We also found that expression of VND7 restores secondary cell wall formation in the fiber cells of inflorescence stems of nst1 nst3 double mutants, as well as expression of NAC SECONDARY WALL THICKENING PROMOTING FACTOR3 (NST3, however, the vessel-type secondary wall deposition was observed only as a result of VND7 expression.	nac	173-176	vascular related NAC-domain protein 7	Arabidopsis thaliana	33-37
21508407-2	2011	In our previous study, biological markers such as estrogen receptor (ER), progesterone receptor (PgR), and HER2 were essential predictors of the effectiveness of NAC to help individualize treatment.	nac	162-165	progesterone receptor	Homo sapiens	97-100
21508407-2	2011	In our previous study, biological markers such as estrogen receptor (ER), progesterone receptor (PgR), and HER2 were essential predictors of the effectiveness of NAC to help individualize treatment.	nac	162-165	erb-b2 receptor tyrosine kinase 2	Homo sapiens	107-111
21220595-12	2011	Residual tumor after NAC in the triple-negative and HER2-positive group is significantly associated with the change in largest diameter of late enhancement during NAC (AUC, 0.76; P &lt; .001).	nac	21-24	erb-b2 receptor tyrosine kinase 2	Homo sapiens	52-56
20593180-9	2011	High pre-operative expressions of Ki-67 (&gt;=50%) and HER-2 (2+) were considered as predictive factors for a better response from NAC.	nac	131-134	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-60
20593180-11	2011	CONCLUSIONS: A non-basal-like phenotype and higher expressions of Ki-67 and HER-2 (2+) were favorable factors for NAC.	nac	114-117	erb-b2 receptor tyrosine kinase 2	Homo sapiens	76-81
22977494-9	2011	p53 overexpression may be a key predictor of a favorable response to NAC.	nac	69-72	tumor protein p53	Homo sapiens	0-3
21300879-10	2011	The FSQ6 gene was identified using map-based cloning approach, and FSQ6 was shown to encode the transcription factor gene Arabidopsis NAC (petunia No apical meristem and Arabidopsis transcription activation factor 1, 2 and Cup-shaped cotyledon 2) domain containing protein 89 (ANAC089).	nac	134-137	NAC domain containing protein 89	Arabidopsis thaliana	4-8
21300879-10	2011	The FSQ6 gene was identified using map-based cloning approach, and FSQ6 was shown to encode the transcription factor gene Arabidopsis NAC (petunia No apical meristem and Arabidopsis transcription activation factor 1, 2 and Cup-shaped cotyledon 2) domain containing protein 89 (ANAC089).	nac	134-137	NAC domain containing protein 89	Arabidopsis thaliana	67-71
21300879-10	2011	The FSQ6 gene was identified using map-based cloning approach, and FSQ6 was shown to encode the transcription factor gene Arabidopsis NAC (petunia No apical meristem and Arabidopsis transcription activation factor 1, 2 and Cup-shaped cotyledon 2) domain containing protein 89 (ANAC089).	nac	134-137	NAC domain containing protein 89	Arabidopsis thaliana	277-284
19760616-9	2011	Furthermore, NAC administration, a scavenger of ROS, reversed beta-BHC-induced apoptosis effects via inhibition of JNKs activation, FasL expression, and NF-kappaB translocation.	nac	13-16	Fas ligand	Rattus norvegicus	132-136
21220595-12	2011	Residual tumor after NAC in the triple-negative and HER2-positive group is significantly associated with the change in largest diameter of late enhancement during NAC (AUC, 0.76; P &lt; .001).	nac	163-166	erb-b2 receptor tyrosine kinase 2	Homo sapiens	52-56
21220595-14	2011	CONCLUSION: MRI during NAC to monitor response is effective in triple-negative or HER2-positive disease but is inaccurate in ER-positive/HER2-negative breast cancer.	nac	23-26	erb-b2 receptor tyrosine kinase 2	Homo sapiens	82-86
21220595-14	2011	CONCLUSION: MRI during NAC to monitor response is effective in triple-negative or HER2-positive disease but is inaccurate in ER-positive/HER2-negative breast cancer.	nac	23-26	estrogen receptor 1	Homo sapiens	83-85
21293471-7	2011	Furthermore, treatment with the ROS scavenger NAC significantly reduced the high glucose-induced TNFalpha and MCP-1 secretion.	nac	46-49	tumor necrosis factor	Rattus norvegicus	97-105
21293471-7	2011	Furthermore, treatment with the ROS scavenger NAC significantly reduced the high glucose-induced TNFalpha and MCP-1 secretion.	nac	46-49	C-C motif chemokine ligand 2	Rattus norvegicus	110-115
21226631-5	2011	Stage IB2 disease had a more favorable response to NAC (95.7%, p = 0.019).	nac	51-54	mitogen-activated protein kinase 8 interacting protein 2	Homo sapiens	6-9
21130128-7	2011	We also observed time-dependent enhancement of Tp53 gene expression after NAC treatment.	nac	74-77	tumor protein p53	Rattus norvegicus	47-51
20443064-2	2011	Based on the microarray results under salt stress and EST information, the full-length cDNAs of two salt-inducible NAC-family genes (SlNAC1, SlNAM1) were isolated from a salt tolerant tomato cultivar, Edkawi, using Rapid Amplification of cDNA Ends (RACE).	nac	115-118	NAC domain protein	Solanum lycopersicum	133-139
20443064-2	2011	Based on the microarray results under salt stress and EST information, the full-length cDNAs of two salt-inducible NAC-family genes (SlNAC1, SlNAM1) were isolated from a salt tolerant tomato cultivar, Edkawi, using Rapid Amplification of cDNA Ends (RACE).	nac	115-118	Nam-like protein 1	Solanum lycopersicum	141-147
21461234-6	2011	We also observed that NAC abolished curcumin-induced activation of extracelluar signal-regulated kinases (ERK) 1/2 and p38 mitogen-activated protein kinases (MAPK), but not Jun N-terminal kinase (JNK).	nac	22-25	mitogen-activated protein kinase 3	Homo sapiens	67-114
21461234-6	2011	We also observed that NAC abolished curcumin-induced activation of extracelluar signal-regulated kinases (ERK) 1/2 and p38 mitogen-activated protein kinases (MAPK), but not Jun N-terminal kinase (JNK).	nac	22-25	mitogen-activated protein kinase 1	Homo sapiens	119-122
21461234-6	2011	We also observed that NAC abolished curcumin-induced activation of extracelluar signal-regulated kinases (ERK) 1/2 and p38 mitogen-activated protein kinases (MAPK), but not Jun N-terminal kinase (JNK).	nac	22-25	mitogen-activated protein kinase 3	Homo sapiens	158-162
21130128-8	2011	Free radicals scavenger N-tert-butyl-alpha-phenylnitrone (PBN, 1 mM) and p53 inhibitor (alpha-Pifithrin, 20 muM) significantly protected PC12 cells against NAC peptide-evoked cell death.	nac	156-159	tumor protein p53	Rattus norvegicus	73-76
21130128-9	2011	In addition, exposure to NAC peptide resulted in higher expression of cyclin-dependent kinase 5 (Cdk5), one of the enzymes responsible for p53 phosphorylation and activation.	nac	25-28	cyclin-dependent kinase 5	Rattus norvegicus	70-95
21130128-9	2011	In addition, exposure to NAC peptide resulted in higher expression of cyclin-dependent kinase 5 (Cdk5), one of the enzymes responsible for p53 phosphorylation and activation.	nac	25-28	cyclin-dependent kinase 5	Rattus norvegicus	97-101
21130128-9	2011	In addition, exposure to NAC peptide resulted in higher expression of cyclin-dependent kinase 5 (Cdk5), one of the enzymes responsible for p53 phosphorylation and activation.	nac	25-28	tumor protein p53	Rattus norvegicus	139-142
21130128-11	2011	Moreover, the specific Cdk5 inhibitor (BML-259, 10 muM) protected large population of cells against NAC-evoked cell death.	nac	100-103	cyclin-dependent kinase 5	Rattus norvegicus	23-27
21130128-12	2011	Our findings indicate that NAC peptide exerts its toxic effect by activation of p53/Cdk5 and Bax-dependent apoptotic signaling pathway.	nac	27-30	tumor protein p53	Rattus norvegicus	80-83
21130128-12	2011	Our findings indicate that NAC peptide exerts its toxic effect by activation of p53/Cdk5 and Bax-dependent apoptotic signaling pathway.	nac	27-30	cyclin-dependent kinase 5	Rattus norvegicus	84-88
21130128-12	2011	Our findings indicate that NAC peptide exerts its toxic effect by activation of p53/Cdk5 and Bax-dependent apoptotic signaling pathway.	nac	27-30	BCL2 associated X, apoptosis regulator	Rattus norvegicus	93-96
21235778-5	2011	RESULTS: NDP, BPH, and HGPIN had higher absolute staining scores for radixin than PCa and NAC, but with a significant difference observed between only HGPIN and PCa (p = &lt; 0.001) and HGPIN and NAC (p = 0.001).	nac	196-199	radixin	Homo sapiens	69-76
21235778-9	2011	The current study has shown that there were statistically significant differences observed between HGPIN and PCa and HGPIN and NAC in terms of radixin expression.	nac	127-130	radixin	Homo sapiens	143-150
22329198-5	2011	Moreover, the ROS scavenger NAC completely inhibited EGCG-induced apoptosis and PrdxV reduction, while overexpression of PrdxV, but not a Prdx(VC48S) mutant, protected IM9 cells from EGCG-induced apoptosis.	nac	28-31	peroxiredoxin 5	Homo sapiens	80-85
22335026-6	2011	The median difference in concentration of TRAIL (dTRAIL) between the initial marking and after two courses of NAC in each patient was 192 pg/ml and it was used for dichotomization of the test group.	nac	110-113	TNF superfamily member 10	Homo sapiens	42-47
22335026-9	2011	After two courses of NAC serum TRAIL concentration level was 1247.49 +/- 378.46 pg/ml (mean +/- SD).	nac	21-24	TNF superfamily member 10	Homo sapiens	31-36
22335026-12	2011	CONCLUSIONS: Serum TRAIL concentration levels changed significantly during NAC.	nac	75-78	TNF superfamily member 10	Homo sapiens	19-24
21389632-1	2011	The NAC (NAM, ATAF, and CUC) proteins share a highly conserved NAC domain and constitute a large family of plant-specific transcriptional factors.	nac	4-7	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	9-12
22156446-3	2011	This study aimed to explore the potential role of miR-221 as a biomarker for chemosensitivity in breast cancer patients who previously received NAC.	nac	144-147	microRNA 221	Homo sapiens	50-57
22156446-4	2011	PATIENTS AND METHODS: The expression levels of circulating miR-221 in the plasma of 93 breast cancer patients who previously received NAC and in 32 healthy individuals were assessed.	nac	134-137	microRNA 221	Homo sapiens	59-66
22156446-9	2011	CONCLUSION: Our results indicate that plasma miR-221 may be a predictive biomarker for sensitivity to NAC in breast cancer patients.	nac	102-105	microRNA 221	Homo sapiens	45-52
20876761-8	2010	Addition of the ROS scavenger, N-acetylcystein (NAC), to palmitate restored both the expression and promoter activity of PGC-1alpha as well as TFAM expression.	nac	48-51	PPARG coactivator 1 alpha	Homo sapiens	121-131
20876761-8	2010	Addition of the ROS scavenger, N-acetylcystein (NAC), to palmitate restored both the expression and promoter activity of PGC-1alpha as well as TFAM expression.	nac	48-51	transcription factor A, mitochondrial	Homo sapiens	143-147
21311680-4	2010	Involvement of ROS in E2F4 downregulation in response to curcumin was confirmed by the result that pretreatment of cells with N-acetylcystein (NAC) before exposure of curcumin almost completely blocked the reduction of E2F4 expression at the protein as well as mRNA level.	nac	143-146	E2F transcription factor 4	Homo sapiens	22-26
20973059-7	2010	CoREST silencing was performed in primarily cultured NAC chondrocytes with specific siRNA to reveal the possible involvement of CoREST repression in chondrocyte phenotypic genes modulation.	nac	53-56	REST corepressor 1	Homo sapiens	0-6
20973059-12	2010	The results indicate that the silencing of CoREST by siRNA transfection in NAC may reflect CoREST repression in AOC, which results in phenotypic genes modulation and suggests a homeostatic role of this transcription factor in articular chondrocyte.	nac	75-78	REST corepressor 1	Homo sapiens	43-49
20973059-12	2010	The results indicate that the silencing of CoREST by siRNA transfection in NAC may reflect CoREST repression in AOC, which results in phenotypic genes modulation and suggests a homeostatic role of this transcription factor in articular chondrocyte.	nac	75-78	REST corepressor 1	Homo sapiens	91-97
21311680-7	2010	Moreover, decreased (cyclin A) and increased (p21 and p27) expression of these E2F4 downstream genes by curcumin was restored by pretreatment of cells with NAC and E2F4 overexpression which is induced by doxycycline.	nac	156-159	cyclin A2	Homo sapiens	21-29
21311680-7	2010	Moreover, decreased (cyclin A) and increased (p21 and p27) expression of these E2F4 downstream genes by curcumin was restored by pretreatment of cells with NAC and E2F4 overexpression which is induced by doxycycline.	nac	156-159	H3 histone pseudogene 16	Homo sapiens	46-49
21311680-4	2010	Involvement of ROS in E2F4 downregulation in response to curcumin was confirmed by the result that pretreatment of cells with N-acetylcystein (NAC) before exposure of curcumin almost completely blocked the reduction of E2F4 expression at the protein as well as mRNA level.	nac	143-146	E2F transcription factor 4	Homo sapiens	219-223
20727930-9	2010	Although NAC (the standard antidote of acetaminophen toxicity) also reduced ALT, AST and TNF-alpha levels, our results show that ghrelin is more potent than NAC in protecting the liver from acetaminophen-induced liver injury.	nac	9-12	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	81-84
21311680-7	2010	Moreover, decreased (cyclin A) and increased (p21 and p27) expression of these E2F4 downstream genes by curcumin was restored by pretreatment of cells with NAC and E2F4 overexpression which is induced by doxycycline.	nac	156-159	interferon alpha inducible protein 27	Homo sapiens	54-57
21311680-7	2010	Moreover, decreased (cyclin A) and increased (p21 and p27) expression of these E2F4 downstream genes by curcumin was restored by pretreatment of cells with NAC and E2F4 overexpression which is induced by doxycycline.	nac	156-159	E2F transcription factor 4	Homo sapiens	79-83
20709382-13	2010	CONCLUSION: The results indicate that NAC followed by surgery plus postoperative chemotherapy but no radiotherapy offers a viable option in the treatment of stage IB2-IIB cervical cancer.	nac	38-41	mitogen-activated protein kinase 8 interacting protein 2	Homo sapiens	163-166
20727930-9	2010	Although NAC (the standard antidote of acetaminophen toxicity) also reduced ALT, AST and TNF-alpha levels, our results show that ghrelin is more potent than NAC in protecting the liver from acetaminophen-induced liver injury.	nac	9-12	tumor necrosis factor	Rattus norvegicus	89-98
20156199-3	2010	The plasma-membrane-anchored NAC (NAM/ATAF/CUC) transcription factor NTL6 is of particular interest.	nac	29-32	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	34-46
21045546-3	2010	It seems very likely that the NAC that has catalyzed dimerization and tRNA annealing is the NC domain of the Gag protein itself.	nac	30-33	Pr55(Gag)	Human immunodeficiency virus 1	109-112
19730975-2	2010	In recent years several biological markers such as estrogen receptor (ER), progesterone receptor (PgR), and HER2 were discovered to be predictive factors for the effectiveness of NAC to help individualize treatment.	nac	179-182	progesterone receptor	Homo sapiens	75-96
19730975-2	2010	In recent years several biological markers such as estrogen receptor (ER), progesterone receptor (PgR), and HER2 were discovered to be predictive factors for the effectiveness of NAC to help individualize treatment.	nac	179-182	progesterone receptor	Homo sapiens	98-101
19730975-2	2010	In recent years several biological markers such as estrogen receptor (ER), progesterone receptor (PgR), and HER2 were discovered to be predictive factors for the effectiveness of NAC to help individualize treatment.	nac	179-182	erb-b2 receptor tyrosine kinase 2	Homo sapiens	108-112
20087581-4	2010	NAC intervention significantly increased CD4(+), CD8(+) and granzyme B(+) infiltration while Foxp3(+) accumulation remained unaffected.	nac	0-3	CD4 molecule	Homo sapiens	41-44
20087581-4	2010	NAC intervention significantly increased CD4(+), CD8(+) and granzyme B(+) infiltration while Foxp3(+) accumulation remained unaffected.	nac	0-3	CD8a molecule	Homo sapiens	49-52
20087581-4	2010	NAC intervention significantly increased CD4(+), CD8(+) and granzyme B(+) infiltration while Foxp3(+) accumulation remained unaffected.	nac	0-3	granzyme B	Homo sapiens	60-70
21045546-9	2010	Recombinant HIV-1 Gag protein clearly exhibits NAC activity.	nac	47-50	Pr55(Gag)	Human immunodeficiency virus 1	18-21
21045546-10	2010	In two well-studied experimental systems, Gag was more efficient than NC, as its NAC effects could be detected at a significantly lower molar ratio of protein to nucleotide than with NC.	nac	81-84	Pr55(Gag)	Human immunodeficiency virus 1	42-45
21046321-1	2010	The plant-specific NAC (NAM, ATAF1/2, and CUC2) transcription factors have a regulatory function in developmental processes and stress responses.	nac	19-22	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	24-27
21046321-1	2010	The plant-specific NAC (NAM, ATAF1/2, and CUC2) transcription factors have a regulatory function in developmental processes and stress responses.	nac	19-22	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	29-36
21046321-1	2010	The plant-specific NAC (NAM, ATAF1/2, and CUC2) transcription factors have a regulatory function in developmental processes and stress responses.	nac	19-22	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	42-46
21053526-12	2010	In the present paper, we also review our experience with high-dose-density NAC in fertility-sparing surgery in 15 women (LAP3-NAC protocol).	nac	75-78	leucine aminopeptidase 3	Homo sapiens	121-125
20632335-2	2010	Subjection of the syn diastereomers to NAC-gold catalysts (NAC=nitrogen acyclic carbene) in the presence of external nucleophiles such as water or anilines provided substituted and highly rigid heterocyclic cages.	nac	39-42	synemin	Homo sapiens	18-21
20632335-2	2010	Subjection of the syn diastereomers to NAC-gold catalysts (NAC=nitrogen acyclic carbene) in the presence of external nucleophiles such as water or anilines provided substituted and highly rigid heterocyclic cages.	nac	59-62	synemin	Homo sapiens	18-21
20596652-1	2010	Neoadjuvant chemotherapy (NAC) by 5-fluorouracil including S-1 is administered to advanced gastric cancer patients.	nac	26-29	proteasome 26S subunit, non-ATPase 1	Homo sapiens	59-62
20596652-11	2010	Effective therapy using tailored S-1 NAC according to the OPRT/TS ratio is therefore expected in advanced gastric cancer patients.	nac	37-40	proteasome 26S subunit, non-ATPase 1	Homo sapiens	33-36
20596652-11	2010	Effective therapy using tailored S-1 NAC according to the OPRT/TS ratio is therefore expected in advanced gastric cancer patients.	nac	37-40	uridine monophosphate synthetase	Homo sapiens	58-62
20591217-10	2010	Pre-incubation with an antioxidant N-acetyl cystein (NAC) decreased the level of ROS, and reduced MAP-LC3 I-II conversion, and suppressed cell death.	nac	53-56	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	102-105
20381562-6	2010	Bilateral intra-VTA (ventral tegmental area) and intra-NAc (nucleus accumbens) injections of NPFF both blocked the CPP caused by morphine in rats.	nac	55-58	neuropeptide FF-amide peptide precursor	Rattus norvegicus	93-97
20381562-7	2010	This suggests that NPFF may act at both VTA and NAc to inhibit the sensitization of the mesocorticolimbic dopaminergic pathway.	nac	48-51	neuropeptide FF-amide peptide precursor	Rattus norvegicus	19-23
20381562-10	2010	Our results showed that both NPFF receptors were abundantly expressed in VTA but with less content in NAc.	nac	102-105	neuropeptide FF-amide peptide precursor	Rattus norvegicus	29-33
20087581-6	2010	In contrast, after NAC, elevated granzyme B(+) infiltration displayed a tendency for improved PFS (log-rank 0.064).	nac	19-22	granzyme B	Homo sapiens	33-43
20087581-8	2010	In addition, high granzyme B(+)/Foxp3(+) ratio post-NAC strongly correlated with improved PFS compared to low granzyme B(+)/Foxp3(+) cell ratio (median 17.88 vs. 11.24 months, respectively), and showed to be a favourable prognostic factor for PFS (log-rank 0.014).	nac	52-55	granzyme B	Homo sapiens	18-28
20087581-8	2010	In addition, high granzyme B(+)/Foxp3(+) ratio post-NAC strongly correlated with improved PFS compared to low granzyme B(+)/Foxp3(+) cell ratio (median 17.88 vs. 11.24 months, respectively), and showed to be a favourable prognostic factor for PFS (log-rank 0.014).	nac	52-55	forkhead box P3	Homo sapiens	32-37
20087581-9	2010	Our findings indicate that NAC elicited an immunologic profile in which low immunosuppressive Foxp3(+) infiltration and elevated numbers of activated granzyme B(+) cells were significantly associated with EOC-specific PFS, suggesting a contribution of immunologic effects to improved clinical outcome.	nac	27-30	forkhead box P3	Homo sapiens	94-99
20087581-9	2010	Our findings indicate that NAC elicited an immunologic profile in which low immunosuppressive Foxp3(+) infiltration and elevated numbers of activated granzyme B(+) cells were significantly associated with EOC-specific PFS, suggesting a contribution of immunologic effects to improved clinical outcome.	nac	27-30	granzyme B	Homo sapiens	150-160
20404534-6	2010	Additionally, 15 senescence-associated NAC genes (senNACs), including ANAC092, respond to H2O2 exposure.	nac	39-42	NAC domain containing protein 6	Arabidopsis thaliana	70-77
20184566-12	2010	CONCLUSIONS: While distinguishing the NAc as a site where ENK and DYN respond differentially, these findings lead us to propose that these opioids, in response to voluntary ethanol consumption, are generally elevated in extra-hypothalamic as well as hypothalamic areas, possibly to carry out specific area-related functions that, in turn, drive animals to further consume ethanol.	nac	38-41	proenkephalin	Rattus norvegicus	58-61
20399802-4	2010	RESULTS: Compared to control EC, hTERT-NAC cells had increased telomerase activity, longer telomeres and underwent more cell divisions.	nac	39-42	telomerase reverse transcriptase	Homo sapiens	33-38
20399802-6	2010	Lack of cell immortalization by hTERT-NAC was accompanied by an absence of beneficial effect of NAC alone in paired EC.	nac	38-41	telomerase reverse transcriptase	Homo sapiens	32-37
20399802-7	2010	Accordingly, lack of EC immortalization by hTERT-NAC was associated with high endogenous susceptibility to oxidation.	nac	49-52	telomerase reverse transcriptase	Homo sapiens	43-48
20399802-8	2010	In EC where hTERT-NAC did not immortalize EC, p53, p21 and p16 expression increased with senescence, while oxidative-dependent DNA damage associated with senescence was not prevented.	nac	18-21	telomerase reverse transcriptase	Homo sapiens	12-17
20156199-3	2010	The plasma-membrane-anchored NAC (NAM/ATAF/CUC) transcription factor NTL6 is of particular interest.	nac	29-32	NAC domain containing protein 62	Arabidopsis thaliana	69-73
20388856-3	2010	Binding assays demonstrated that VNI2 effectively interacts with VND7 and the VND family proteins, VND1-5, as well as with other NAC domain proteins at lower affinity.	nac	129-132	NAC domain containing protein 83	Arabidopsis thaliana	33-37
19913060-1	2010	Residues 61-95 of the non-amyloid component (NAC(61-95)) domain of alpha-synuclein are responsible for the aggregation and neurotoxicity of this protein.	nac	45-48	synuclein alpha	Rattus norvegicus	67-82
19931572-1	2010	Pre-aggregated non-amyloid component of alpha-synuclein, NAC(61-95), was injected bilaterally into the CA3 area of rat hippocampus and behaviour was assessed using an alternating-lever cyclic-ratio (ALCR) schedule of operant responding.	nac	57-60	synuclein alpha	Rattus norvegicus	40-55
20197506-3	2010	Here, we demonstrate that the cellular maturation of root cap is redundantly regulated by three genes, SOMBRERO (SMB), BEARSKIN1 (BRN1), and BRN2, which are members of the Class IIB NAC transcription factor family, together with the VASCULAR NAC DOMAIN (VND) and NAC SECONDARY WALL THICKENING PROMOTING FACTOR (NST) genes that regulate secondary cell wall synthesis in specialized cell types.	nac	182-185	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	103-111
20197506-3	2010	Here, we demonstrate that the cellular maturation of root cap is redundantly regulated by three genes, SOMBRERO (SMB), BEARSKIN1 (BRN1), and BRN2, which are members of the Class IIB NAC transcription factor family, together with the VASCULAR NAC DOMAIN (VND) and NAC SECONDARY WALL THICKENING PROMOTING FACTOR (NST) genes that regulate secondary cell wall synthesis in specialized cell types.	nac	182-185	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	113-116
20197506-3	2010	Here, we demonstrate that the cellular maturation of root cap is redundantly regulated by three genes, SOMBRERO (SMB), BEARSKIN1 (BRN1), and BRN2, which are members of the Class IIB NAC transcription factor family, together with the VASCULAR NAC DOMAIN (VND) and NAC SECONDARY WALL THICKENING PROMOTING FACTOR (NST) genes that regulate secondary cell wall synthesis in specialized cell types.	nac	182-185	NAC domain containing protein 15	Arabidopsis thaliana	119-128
20197506-3	2010	Here, we demonstrate that the cellular maturation of root cap is redundantly regulated by three genes, SOMBRERO (SMB), BEARSKIN1 (BRN1), and BRN2, which are members of the Class IIB NAC transcription factor family, together with the VASCULAR NAC DOMAIN (VND) and NAC SECONDARY WALL THICKENING PROMOTING FACTOR (NST) genes that regulate secondary cell wall synthesis in specialized cell types.	nac	182-185	NAC domain containing protein 15	Arabidopsis thaliana	130-134
20197506-3	2010	Here, we demonstrate that the cellular maturation of root cap is redundantly regulated by three genes, SOMBRERO (SMB), BEARSKIN1 (BRN1), and BRN2, which are members of the Class IIB NAC transcription factor family, together with the VASCULAR NAC DOMAIN (VND) and NAC SECONDARY WALL THICKENING PROMOTING FACTOR (NST) genes that regulate secondary cell wall synthesis in specialized cell types.	nac	182-185	NAC domain containing protein 70	Arabidopsis thaliana	141-145
20197506-3	2010	Here, we demonstrate that the cellular maturation of root cap is redundantly regulated by three genes, SOMBRERO (SMB), BEARSKIN1 (BRN1), and BRN2, which are members of the Class IIB NAC transcription factor family, together with the VASCULAR NAC DOMAIN (VND) and NAC SECONDARY WALL THICKENING PROMOTING FACTOR (NST) genes that regulate secondary cell wall synthesis in specialized cell types.	nac	242-245	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	103-111
20197506-3	2010	Here, we demonstrate that the cellular maturation of root cap is redundantly regulated by three genes, SOMBRERO (SMB), BEARSKIN1 (BRN1), and BRN2, which are members of the Class IIB NAC transcription factor family, together with the VASCULAR NAC DOMAIN (VND) and NAC SECONDARY WALL THICKENING PROMOTING FACTOR (NST) genes that regulate secondary cell wall synthesis in specialized cell types.	nac	242-245	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	113-116
20197506-3	2010	Here, we demonstrate that the cellular maturation of root cap is redundantly regulated by three genes, SOMBRERO (SMB), BEARSKIN1 (BRN1), and BRN2, which are members of the Class IIB NAC transcription factor family, together with the VASCULAR NAC DOMAIN (VND) and NAC SECONDARY WALL THICKENING PROMOTING FACTOR (NST) genes that regulate secondary cell wall synthesis in specialized cell types.	nac	242-245	NAC domain containing protein 15	Arabidopsis thaliana	119-128
20197506-3	2010	Here, we demonstrate that the cellular maturation of root cap is redundantly regulated by three genes, SOMBRERO (SMB), BEARSKIN1 (BRN1), and BRN2, which are members of the Class IIB NAC transcription factor family, together with the VASCULAR NAC DOMAIN (VND) and NAC SECONDARY WALL THICKENING PROMOTING FACTOR (NST) genes that regulate secondary cell wall synthesis in specialized cell types.	nac	242-245	NAC domain containing protein 15	Arabidopsis thaliana	130-134
20197506-3	2010	Here, we demonstrate that the cellular maturation of root cap is redundantly regulated by three genes, SOMBRERO (SMB), BEARSKIN1 (BRN1), and BRN2, which are members of the Class IIB NAC transcription factor family, together with the VASCULAR NAC DOMAIN (VND) and NAC SECONDARY WALL THICKENING PROMOTING FACTOR (NST) genes that regulate secondary cell wall synthesis in specialized cell types.	nac	242-245	NAC domain containing protein 70	Arabidopsis thaliana	141-145
19995345-2	2010	NAC [for NAM (no apical meristem), ATAF, CUC (cup-shaped cotyledon)] proteins comprise one of the largest plant TF families.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	9-12
19995345-12	2010	Chimaeric proteins, where the NAC domain of ANAC019 was replaced with the analogous regions from other NAC TFs, also have the ability to positively regulate ABA signalling.	nac	30-33	NAC domain containing protein 19	Arabidopsis thaliana	44-51
20074151-10	2010	The antioxidant N-acetyl cystein (NAC) efficiently reversed the NEIL1 repression by inhibiting ROS induction by HCV.	nac	34-37	nei like DNA glycosylase 1	Homo sapiens	64-69
19788396-8	2010	Colony formation from NAC was observed in the presence of IL-7 (CFU-IL-7).	nac	22-25	interleukin 7	Mus musculus	58-62
19788396-8	2010	Colony formation from NAC was observed in the presence of IL-7 (CFU-IL-7).	nac	22-25	interleukin 7	Mus musculus	64-72
19809429-1	2009	BACKGROUND: To evaluate the impact of change in the hormone receptor (HR) status (HR status conversion) on the long-term outcomes of breast cancer patients treated with neoadjuvant chemotherapy (NAC).	nac	195-198	nuclear receptor subfamily 4 group A member 1	Homo sapiens	52-68
19947982-4	2010	Here, we demonstrate that cold stimulates proteolytic activation of a plasma membrane-tethered NAC (NAM/ATAF1/2/CUC2) transcription factor NTL6.	nac	95-98	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	100-103
19947982-4	2010	Here, we demonstrate that cold stimulates proteolytic activation of a plasma membrane-tethered NAC (NAM/ATAF1/2/CUC2) transcription factor NTL6.	nac	95-98	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	104-111
19947982-4	2010	Here, we demonstrate that cold stimulates proteolytic activation of a plasma membrane-tethered NAC (NAM/ATAF1/2/CUC2) transcription factor NTL6.	nac	95-98	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	112-116
19947982-4	2010	Here, we demonstrate that cold stimulates proteolytic activation of a plasma membrane-tethered NAC (NAM/ATAF1/2/CUC2) transcription factor NTL6.	nac	95-98	NAC domain containing protein 62	Arabidopsis thaliana	139-143
19730128-8	2010	The levels of transforming growth factor alpha and NO secreted by AMs in the ANP and the ANP plus NAC group rose significantly over that in the control group, and there was a significant difference between them.	nac	98-101	transforming growth factor alpha	Rattus norvegicus	14-46
19809429-1	2009	BACKGROUND: To evaluate the impact of change in the hormone receptor (HR) status (HR status conversion) on the long-term outcomes of breast cancer patients treated with neoadjuvant chemotherapy (NAC).	nac	195-198	nuclear receptor subfamily 4 group A member 1	Homo sapiens	70-72
19809429-1	2009	BACKGROUND: To evaluate the impact of change in the hormone receptor (HR) status (HR status conversion) on the long-term outcomes of breast cancer patients treated with neoadjuvant chemotherapy (NAC).	nac	195-198	nuclear receptor subfamily 4 group A member 1	Homo sapiens	82-84
19759343-6	2009	To understand the function of NPX1, we searched for interacting proteins and found that an ABA-inducible NAC transcription factor, TIP, interacted with NPX1.	nac	105-108	nuclear protein X1	Arabidopsis thaliana	30-34
19759343-6	2009	To understand the function of NPX1, we searched for interacting proteins and found that an ABA-inducible NAC transcription factor, TIP, interacted with NPX1.	nac	105-108	nuclear protein X1	Arabidopsis thaliana	152-156
19722699-3	2009	The middle hydrophobic region of the alpha-synuclein protein, also termed the "non-Abeta component of Alzheimer"s disease amyloid plaque (NAC)" domain, is required for alpha-synuclein to polymerize into amyloid filaments, which are the major components of alpha-synuclein pathological inclusions.	nac	138-141	synuclein alpha	Homo sapiens	37-52
20081243-2	2009	The central domain of alpha-synuclein, the non-amyloid beta component of the Alzheimer"s disease amyloid (NAC) is probably responsible for its toxicity.	nac	106-109	synuclein alpha	Rattus norvegicus	22-37
19722699-3	2009	The middle hydrophobic region of the alpha-synuclein protein, also termed the "non-Abeta component of Alzheimer"s disease amyloid plaque (NAC)" domain, is required for alpha-synuclein to polymerize into amyloid filaments, which are the major components of alpha-synuclein pathological inclusions.	nac	138-141	synuclein alpha	Homo sapiens	168-183
19722699-3	2009	The middle hydrophobic region of the alpha-synuclein protein, also termed the "non-Abeta component of Alzheimer"s disease amyloid plaque (NAC)" domain, is required for alpha-synuclein to polymerize into amyloid filaments, which are the major components of alpha-synuclein pathological inclusions.	nac	138-141	synuclein alpha	Homo sapiens	168-183
19548978-7	2009	A large pair-wise interaction test against the REGIA transcription factor collection revealed that RCD1 interacts with a large number of transcription factors belonging to several protein families, such as AP2/ERF, NAC and basic helix-loop-helix (bHLH), and that SRO1 interacts with a smaller subset of these.	nac	215-218	WWE protein-protein interaction domain protein family	Arabidopsis thaliana	99-103
19694953-7	2009	Combining microarray analysis with reverse genetics using T-DNA insertion lines, four additional ARR genes were identified as contributing to ARR: two plant-specific transcription factors of the NAC family [ANAC055 (At3g15500) and ANAC092 (At5g39610)], a UDP-glucose glucosyltransferase [UGT85A1 (At1g22400)] and a cytidine deaminase [CDA1 (At2g19570)].	nac	195-198	NAC domain containing protein 3	Arabidopsis thaliana	207-214
19694953-7	2009	Combining microarray analysis with reverse genetics using T-DNA insertion lines, four additional ARR genes were identified as contributing to ARR: two plant-specific transcription factors of the NAC family [ANAC055 (At3g15500) and ANAC092 (At5g39610)], a UDP-glucose glucosyltransferase [UGT85A1 (At1g22400)] and a cytidine deaminase [CDA1 (At2g19570)].	nac	195-198	NAC domain containing protein 6	Arabidopsis thaliana	231-238
19694953-7	2009	Combining microarray analysis with reverse genetics using T-DNA insertion lines, four additional ARR genes were identified as contributing to ARR: two plant-specific transcription factors of the NAC family [ANAC055 (At3g15500) and ANAC092 (At5g39610)], a UDP-glucose glucosyltransferase [UGT85A1 (At1g22400)] and a cytidine deaminase [CDA1 (At2g19570)].	nac	195-198	UDP-Glycosyltransferase superfamily protein	Arabidopsis thaliana	288-295
19694953-7	2009	Combining microarray analysis with reverse genetics using T-DNA insertion lines, four additional ARR genes were identified as contributing to ARR: two plant-specific transcription factors of the NAC family [ANAC055 (At3g15500) and ANAC092 (At5g39610)], a UDP-glucose glucosyltransferase [UGT85A1 (At1g22400)] and a cytidine deaminase [CDA1 (At2g19570)].	nac	195-198	cytidine deaminase 1	Arabidopsis thaliana	335-339
19723101-5	2009	By treating cells with high concentrations of the reactive oxygen species (ROS) scavenger NAC (N-acetyl-1-cysteine), the apoptotic effect of EGCG was abolished and led to suppression of AMPK and COX-2, indicating that the liberation of excessive ROS might be the upstream signal of the AMPK-COX-2 signaling pathway even in the presence of low-dose H(2)O(2).	nac	90-93	prostaglandin-endoperoxide synthase 2	Homo sapiens	195-200
19410626-2	2009	Aggregated alpha-synuclein protein is the major component of LB"s and the non-amyloid component (NAC) region of alpha-synuclein, residues 61-95, is essential for the aggregation and toxicity of this protein.	nac	97-100	synuclein alpha	Rattus norvegicus	112-127
19410626-3	2009	The current study evaluated the effect of pre-aggregated NAC(61-95) injected into the CA3 area of the dorsal hippocampus of the brain on memory in the rat.	nac	57-60	carbonic anhydrase 3	Rattus norvegicus	86-89
19549833-3	2009	This gene is a member of the NAC domain [petunia NAM (no apical meristem) and Arabidopsis ATAF1, 2 and CUC2] family (a family of proteins unique to land plants).	nac	29-32	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	49-52
19549833-3	2009	This gene is a member of the NAC domain [petunia NAM (no apical meristem) and Arabidopsis ATAF1, 2 and CUC2] family (a family of proteins unique to land plants).	nac	29-32	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	90-95
19549833-3	2009	This gene is a member of the NAC domain [petunia NAM (no apical meristem) and Arabidopsis ATAF1, 2 and CUC2] family (a family of proteins unique to land plants).	nac	29-32	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	103-107
19723101-5	2009	By treating cells with high concentrations of the reactive oxygen species (ROS) scavenger NAC (N-acetyl-1-cysteine), the apoptotic effect of EGCG was abolished and led to suppression of AMPK and COX-2, indicating that the liberation of excessive ROS might be the upstream signal of the AMPK-COX-2 signaling pathway even in the presence of low-dose H(2)O(2).	nac	90-93	prostaglandin-endoperoxide synthase 2	Homo sapiens	291-296
19273429-3	2009	A cDNA encoding the NAC-like gene homologue was isolated from maize (Zea mays L.) by RT-PCR and designated ZmNAC1 (GenBank Accession No.	nac	20-23	NAC domain-containing protein 2	Zea mays	107-113
19477897-1	2009	OBJECTIVE: Determinants of long-term outcome of patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer who received neoadjuvant chemotherapy (NAC) are not clear.	nac	172-175	erb-b2 receptor tyrosine kinase 2	Homo sapiens	68-102
19477897-1	2009	OBJECTIVE: Determinants of long-term outcome of patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer who received neoadjuvant chemotherapy (NAC) are not clear.	nac	172-175	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-108
19477897-2	2009	The purpose of this study was to explore the prognostic factors of HER2-positive breast cancer patients administered NAC.	nac	117-120	erb-b2 receptor tyrosine kinase 2	Homo sapiens	67-71
19477897-10	2009	CONCLUSIONS: The pathological axillary node status and age were found to be the significant prognostic factors in HER2-positive breast cancer patients who received NAC.	nac	164-167	erb-b2 receptor tyrosine kinase 2	Homo sapiens	114-118
19563645-2	2009	The aim of our study was to investigate the association between XRCC1 gene single nucleotide polymorphisms (SNPs) and NAC response.	nac	118-121	X-ray repair cross complementing 1	Homo sapiens	64-69
19563645-5	2009	The association of XRCC1 gene SNPs and protein expression with NAC response were analyzed.	nac	63-66	X-ray repair cross complementing 1	Homo sapiens	19-24
19176720-3	2009	The Arabidopsis (Arabidopsis thaliana) NAC domain-containing gene ANAC102 was shown to be induced under 0.1% oxygen within 30 min in both roots and shoots as well as in 0.1% oxygen-treated germinating seeds.	nac	39-42	NAC domain containing protein 102	Arabidopsis thaliana	66-73
19362120-6	2009	Peripheral administration of ghrelin decreased dopamine levels in the NAc when food was removed following ghrelin administration.	nac	70-73	ghrelin and obestatin prepropeptide	Rattus norvegicus	29-36
19362120-6	2009	Peripheral administration of ghrelin decreased dopamine levels in the NAc when food was removed following ghrelin administration.	nac	70-73	ghrelin and obestatin prepropeptide	Rattus norvegicus	106-113
19362120-11	2009	Furthermore, local injection of ghrelin into the VTA induced dopamine release in the NAc and food consumption, supporting the local action of ghrelin in the VTA.	nac	85-88	ghrelin and obestatin prepropeptide	Rattus norvegicus	32-39
19362120-11	2009	Furthermore, local injection of ghrelin into the VTA induced dopamine release in the NAc and food consumption, supporting the local action of ghrelin in the VTA.	nac	85-88	ghrelin and obestatin prepropeptide	Rattus norvegicus	142-149
19563645-8	2009	The expression level of XRCC1 protein was significantly associated with response to NAC.	nac	84-87	X-ray repair cross complementing 1	Homo sapiens	24-29
19563645-10	2009	CONCLUSION: SNP of XRCC1 gene at codon 399 influences the response of cervical carcinoma to platinum-based NAC.	nac	107-110	X-ray repair cross complementing 1	Homo sapiens	19-24
18851872-9	2008	In subgroup analysis with 39 patients who were treated with regimens containing 5-fluorouracil (5-FU), the genotypes of GGH-401Cytosine/Thymine were significantly associated with the response to NAC (P=0.039).	nac	195-198	gamma-glutamyl hydrolase	Homo sapiens	120-123
19019722-5	2008	In this review, we highlight the most recent findings on Arabidopsis MTTFs that ascribe different yet important roles to these proteins: the MTTFs in the bZIP family appear to regulate stress signaling pathways, whereas members of the NAC family are involved in both development and stress response.	nac	235-238	basic leucine-zipper 8	Arabidopsis thaliana	154-158
18851872-7	2008	RESULTS: The genotypes of XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine were significantly associated with the response to NAC (P=0.023 for XRCC1 Arginine194Tryptophan; P=0.046 for GGH-401Cytosine/Thymine).	nac	133-136	X-ray repair cross complementing 1	Homo sapiens	26-31
19022250-10	2009	In order to increase aggregation of alpha-synuclein, specific cleavage between the highly charged C-terminal domain and the aggregation-prone NAC domain of alpha-synuclein seems to be crucial.	nac	142-145	synuclein alpha	Homo sapiens	36-51
19022250-10	2009	In order to increase aggregation of alpha-synuclein, specific cleavage between the highly charged C-terminal domain and the aggregation-prone NAC domain of alpha-synuclein seems to be crucial.	nac	142-145	synuclein alpha	Homo sapiens	156-171
18851872-7	2008	RESULTS: The genotypes of XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine were significantly associated with the response to NAC (P=0.023 for XRCC1 Arginine194Tryptophan; P=0.046 for GGH-401Cytosine/Thymine).	nac	133-136	gamma-glutamyl hydrolase	Homo sapiens	58-61
18851872-10	2008	In multifactor dimensionality reduction (MDR) analysis, the combination of XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine genotypes was associated with the response to NAC (P&lt;0.001).	nac	177-180	X-ray repair cross complementing 1	Homo sapiens	75-80
18851872-7	2008	RESULTS: The genotypes of XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine were significantly associated with the response to NAC (P=0.023 for XRCC1 Arginine194Tryptophan; P=0.046 for GGH-401Cytosine/Thymine).	nac	133-136	X-ray repair cross complementing 1	Homo sapiens	150-155
18851872-7	2008	RESULTS: The genotypes of XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine were significantly associated with the response to NAC (P=0.023 for XRCC1 Arginine194Tryptophan; P=0.046 for GGH-401Cytosine/Thymine).	nac	133-136	gamma-glutamyl hydrolase	Homo sapiens	191-194
18851872-10	2008	In multifactor dimensionality reduction (MDR) analysis, the combination of XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine genotypes was associated with the response to NAC (P&lt;0.001).	nac	177-180	gamma-glutamyl hydrolase	Homo sapiens	107-110
18851872-12	2008	CONCLUSIONS: The genotypes of XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine were associated with the response to NAC in patients with cervical cancer.	nac	123-126	X-ray repair cross complementing 1	Homo sapiens	30-35
18851872-12	2008	CONCLUSIONS: The genotypes of XRCC1 Arginine194Tryptophan and GGH-401Cytosine/Thymine were associated with the response to NAC in patients with cervical cancer.	nac	123-126	gamma-glutamyl hydrolase	Homo sapiens	62-65
18694460-0	2008	Transcriptional regulation by an NAC (NAM-ATAF1,2-CUC2) transcription factor attenuates ABA signalling for efficient basal defence towards Blumeria graminis f. sp.	nac	33-36	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	42-47
18588920-7	2008	The effect was blocked by the antagonist (Nphe(1))nociceptin(1-13)NH(2) and attenuated by U0126, suggesting that the activation of ERK pathways is involved in the OFQ-induced nociceptive effect in the NAc of rats.	nac	201-204	Eph receptor B1	Rattus norvegicus	131-134
18588920-4	2008	Moreover, the intra-NAc injection of OFQ-induced decreases in HWLs were antagonized by intra-NAc injection of (Nphe(1))nociceptin(1-13)NH(2), an antagonist of ORL1 receptor, in a dose-dependent way.	nac	20-23	prepronociceptin	Rattus norvegicus	119-129
18657234-3	2008	We show here that secondary wall formation in siliques is necessary for dehiscence, and that two plant-specific transcription factors, NAC SECONDARY WALL THICKENING PROMOTING FACTOR 1 and 3 (NST1 and NST3), regulate its formation in siliques of Arabidopsis.	nac	135-138	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	191-195
18657234-3	2008	We show here that secondary wall formation in siliques is necessary for dehiscence, and that two plant-specific transcription factors, NAC SECONDARY WALL THICKENING PROMOTING FACTOR 1 and 3 (NST1 and NST3), regulate its formation in siliques of Arabidopsis.	nac	135-138	NAC domain containing protein 12	Arabidopsis thaliana	200-204
18729150-10	2008	Taken together, these findings suggest that alpha-taxilin plays multiple roles in the generation and maintenance of neurons through modulation of the NAC-mediated translational machinary and/or the syntaxin-mediated vesicle traffic in the soma.	nac	150-153	taxilin alpha	Rattus norvegicus	44-57
18588920-4	2008	Moreover, the intra-NAc injection of OFQ-induced decreases in HWLs were antagonized by intra-NAc injection of (Nphe(1))nociceptin(1-13)NH(2), an antagonist of ORL1 receptor, in a dose-dependent way.	nac	20-23	opioid related nociceptin receptor 1	Rattus norvegicus	159-163
18588920-4	2008	Moreover, the intra-NAc injection of OFQ-induced decreases in HWLs were antagonized by intra-NAc injection of (Nphe(1))nociceptin(1-13)NH(2), an antagonist of ORL1 receptor, in a dose-dependent way.	nac	93-96	prepronociceptin	Rattus norvegicus	119-129
18785827-2	2008	The CP also interacts with a nuclear-targeted NAC family of host transcription factors, designated TIP (TCV-interacting protein).	nac	46-49	TOR signaling pathway regulator	Homo sapiens	99-102
18534850-3	2008	We investigated whether the status of estrogen receptor (ER), progesterone receptor (PR) and Her-2 expressions in breast cancer cases prior to NAC could be changed after NAC.	nac	143-146	erb-b2 receptor tyrosine kinase 2	Homo sapiens	93-98
18534850-3	2008	We investigated whether the status of estrogen receptor (ER), progesterone receptor (PR) and Her-2 expressions in breast cancer cases prior to NAC could be changed after NAC.	nac	170-173	erb-b2 receptor tyrosine kinase 2	Homo sapiens	93-98
18534850-6	2008	Changes in Her-2 status were suspected in four specimens after NAC (3+ to 1+ for 3 patients, and 1+ to 3+ for one patient) according to the IHC results.	nac	63-66	erb-b2 receptor tyrosine kinase 2	Homo sapiens	11-16
18722803-4	2008	Recent studies have shown that several members of the bZIP and NAC families in Arabidopsis are membrane-associated and are activated by membrane-associated proteases during stress responses in the endoplasmic reticulum and when the plants experience environmental stresses.	nac	63-66	basic leucine-zipper 8	Arabidopsis thaliana	54-58
18849494-0	2008	NAC family proteins NARS1/NAC2 and NARS2/NAM in the outer integument regulate embryogenesis in Arabidopsis.	nac	0-3	NAC domain containing protein 2	Arabidopsis thaliana	20-25
18849494-0	2008	NAC family proteins NARS1/NAC2 and NARS2/NAM in the outer integument regulate embryogenesis in Arabidopsis.	nac	0-3	NAC domain containing protein 2	Arabidopsis thaliana	26-30
18849494-0	2008	NAC family proteins NARS1/NAC2 and NARS2/NAM in the outer integument regulate embryogenesis in Arabidopsis.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	35-40
18849494-0	2008	NAC family proteins NARS1/NAC2 and NARS2/NAM in the outer integument regulate embryogenesis in Arabidopsis.	nac	0-3	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	41-44
18642828-1	2008	A highly pure MUC1-derived glycopeptide dendrimer of 22 kDa was prepared by a sequential segment coupling, achieved by an N-alkylcysteine (NAC)-assisted thioesterification.	nac	139-142	mucin 1, cell surface associated	Homo sapiens	14-18
18436315-9	2008	We show that overexpression of uPA in the Nac significantly augments cocaine-induced place preference.	nac	42-45	plasminogen activator, urokinase	Rattus norvegicus	31-34
18573614-6	2008	Profoundly, pretreatment with thiol-containing compounds NAC or GSH, but not vitamin E, blocked GSH depletion, 38 MAPK activation and MKP-1 expression by cadmium.	nac	57-60	dual specificity phosphatase 1	Rattus norvegicus	134-139
18426993-8	2008	Cotreatment with ACE inhibitor, angiotensin type 1 receptor blocker, or antioxidants (NAC 3 mmol/L, Apocynin 200 micromol/L) reduced ROS levels, improved the number of DilLDL/BS-1 lectin-positive cells by around 1.5-fold, and restored BM-MNCs proangiogenic effects in ischemic hindlimb.	nac	86-89	angiotensin I converting enzyme	Rattus norvegicus	17-20
18445131-7	2008	Furthermore, a yeast two-hybrid assay revealed the ability of VND7 to form homodimers and heterodimers with other VND proteins via their N-termini, which include the NAC domain.	nac	166-169	vascular related NAC-domain protein 7	Arabidopsis thaliana	62-66
18625073-8	2008	During the 8 hour period following NAC, loratadine and the CBP both reduced NSS compared with placebo (P = 0.034 and P = 0.029, respectively).	nac	35-38	eukaryotic translation initiation factor 4E	Homo sapiens	59-62
18625073-9	2008	Analysis of nasal lavage fluid demonstrated that the CBP prevented the increase in prostaglandin D2 release following NAC, while neither loratadine nor placebo had this effect.	nac	118-121	eukaryotic translation initiation factor 4E	Homo sapiens	53-56
18625073-11	2008	CONCLUSION: The CBP significantly reduced NSS during the 8 hours following NAC and marginally inhibited the release of prostaglandin D2 into nasal lavage fluid, suggesting potential clinical utility in patients with allergic rhinitis.	nac	75-78	eukaryotic translation initiation factor 4E	Homo sapiens	16-19
18326880-5	2008	RESULTS: (i) CYP2E1 was expressed in PFC, Nac, and VTA, with the order of magnitude of the levels being VTA approximately PFC &gt; Nac, and approximately 3-13% of it was encountered in liver; (ii) acetone treatment significantly increased CYP2E1 expression in Nac, up to 212% of the control levels, whereas not significant changes were observed in VTA and PFC; (iii) chronic ethanol treatment only resulted in a significant induction of enzyme levels in VTA (124%).	nac	42-45	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	13-19
18326880-5	2008	RESULTS: (i) CYP2E1 was expressed in PFC, Nac, and VTA, with the order of magnitude of the levels being VTA approximately PFC &gt; Nac, and approximately 3-13% of it was encountered in liver; (ii) acetone treatment significantly increased CYP2E1 expression in Nac, up to 212% of the control levels, whereas not significant changes were observed in VTA and PFC; (iii) chronic ethanol treatment only resulted in a significant induction of enzyme levels in VTA (124%).	nac	131-134	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	13-19
18326880-5	2008	RESULTS: (i) CYP2E1 was expressed in PFC, Nac, and VTA, with the order of magnitude of the levels being VTA approximately PFC &gt; Nac, and approximately 3-13% of it was encountered in liver; (ii) acetone treatment significantly increased CYP2E1 expression in Nac, up to 212% of the control levels, whereas not significant changes were observed in VTA and PFC; (iii) chronic ethanol treatment only resulted in a significant induction of enzyme levels in VTA (124%).	nac	131-134	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	13-19
18427573-4	2008	The anac019 anac055 double mutant plants showed attenuated JA-induced VEGETATIVE STORAGE PROTEIN1 (VSP1) and LIPOXYGENASE2 (LOX2) expression, whereas transgenic plants overexpressing the two NAC genes showed enhanced JA-induced VSP1 and LOX2 expression.	nac	191-194	NAC domain containing protein 19	Arabidopsis thaliana	4-11
18427573-4	2008	The anac019 anac055 double mutant plants showed attenuated JA-induced VEGETATIVE STORAGE PROTEIN1 (VSP1) and LIPOXYGENASE2 (LOX2) expression, whereas transgenic plants overexpressing the two NAC genes showed enhanced JA-induced VSP1 and LOX2 expression.	nac	191-194	NAC domain containing protein 3	Arabidopsis thaliana	12-19
18427573-5	2008	That the JA-induced expression of the two NAC genes depends on the function of COI1 and AtMYC2, together with the finding that overexpression of ANAC019 partially rescued the JA-related phenotype of the atmyc2-2 mutant, has led us to a hypothesis that the two NAC proteins act downstream of AtMYC2 to regulate JA-signaled defense responses.	nac	42-45	RNI-like superfamily protein	Arabidopsis thaliana	79-83
18427573-5	2008	That the JA-induced expression of the two NAC genes depends on the function of COI1 and AtMYC2, together with the finding that overexpression of ANAC019 partially rescued the JA-related phenotype of the atmyc2-2 mutant, has led us to a hypothesis that the two NAC proteins act downstream of AtMYC2 to regulate JA-signaled defense responses.	nac	42-45	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	88-94
18427573-5	2008	That the JA-induced expression of the two NAC genes depends on the function of COI1 and AtMYC2, together with the finding that overexpression of ANAC019 partially rescued the JA-related phenotype of the atmyc2-2 mutant, has led us to a hypothesis that the two NAC proteins act downstream of AtMYC2 to regulate JA-signaled defense responses.	nac	42-45	NAC domain containing protein 19	Arabidopsis thaliana	145-152
18427573-5	2008	That the JA-induced expression of the two NAC genes depends on the function of COI1 and AtMYC2, together with the finding that overexpression of ANAC019 partially rescued the JA-related phenotype of the atmyc2-2 mutant, has led us to a hypothesis that the two NAC proteins act downstream of AtMYC2 to regulate JA-signaled defense responses.	nac	42-45	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	203-209
18427573-5	2008	That the JA-induced expression of the two NAC genes depends on the function of COI1 and AtMYC2, together with the finding that overexpression of ANAC019 partially rescued the JA-related phenotype of the atmyc2-2 mutant, has led us to a hypothesis that the two NAC proteins act downstream of AtMYC2 to regulate JA-signaled defense responses.	nac	42-45	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	291-297
18427573-5	2008	That the JA-induced expression of the two NAC genes depends on the function of COI1 and AtMYC2, together with the finding that overexpression of ANAC019 partially rescued the JA-related phenotype of the atmyc2-2 mutant, has led us to a hypothesis that the two NAC proteins act downstream of AtMYC2 to regulate JA-signaled defense responses.	nac	146-149	RNI-like superfamily protein	Arabidopsis thaliana	79-83
18427573-5	2008	That the JA-induced expression of the two NAC genes depends on the function of COI1 and AtMYC2, together with the finding that overexpression of ANAC019 partially rescued the JA-related phenotype of the atmyc2-2 mutant, has led us to a hypothesis that the two NAC proteins act downstream of AtMYC2 to regulate JA-signaled defense responses.	nac	146-149	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	203-209
18427573-5	2008	That the JA-induced expression of the two NAC genes depends on the function of COI1 and AtMYC2, together with the finding that overexpression of ANAC019 partially rescued the JA-related phenotype of the atmyc2-2 mutant, has led us to a hypothesis that the two NAC proteins act downstream of AtMYC2 to regulate JA-signaled defense responses.	nac	146-149	Basic helix-loop-helix (bHLH) DNA-binding family protein	Arabidopsis thaliana	291-297
18445109-11	2008	On the other hand, mRNA and protein levels of BDNF were similar in the NAc shell and core structures of P and NP rats.	nac	71-74	brain-derived neurotrophic factor	Rattus norvegicus	46-50
19062520-2	2008	We compared the effect of N-acetylcystein (NAC) and alpha-lipoic acid (ALA) on two gelatinases, MMP-2 and MMP-9.	nac	43-46	matrix metallopeptidase 2	Mus musculus	96-101
18374634-2	2008	This vector, Nac-6-IOPs/Ad/LacZ, binds to K562 cells in the presence of external magnetic fields and results in enhanced expression of the transgene in those cells that do not exhibit the coxsackie-adenovirus receptor (CAR).	nac	13-16	CXADR Ig-like cell adhesion molecule	Homo sapiens	188-217
18374634-2	2008	This vector, Nac-6-IOPs/Ad/LacZ, binds to K562 cells in the presence of external magnetic fields and results in enhanced expression of the transgene in those cells that do not exhibit the coxsackie-adenovirus receptor (CAR).	nac	13-16	CXADR Ig-like cell adhesion molecule	Homo sapiens	219-222
18374634-3	2008	Our results demonstrate that Nac-6-IOPs/Ad/LacZ is able to transduce K562 cells specifically with reduced infection of CAR- cells.	nac	29-32	CXADR Ig-like cell adhesion molecule	Homo sapiens	119-122
18510179-13	2008	The p53 Ab-negative patients may predict a high clinical OR rate in anthracycline-based NAC.	nac	88-91	tumor protein p53	Homo sapiens	4-7
18510179-14	2008	HER-2-negative may predict a high OR in both taxane-based and anthracycline-based NAC.	nac	82-85	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
19704445-3	2008	In the mesolimbic dopaminergic reward circuit, including the ventral tegmental area (VTA) and the ventral striatum/nucleus accumbens (NAc) we found a positive influence of PERIOD 2 (PER2) on transcriptional activation of Maoa using mice mutant in the Per2 gene.	nac	134-137	period circadian clock 2	Mus musculus	172-180
19704445-3	2008	In the mesolimbic dopaminergic reward circuit, including the ventral tegmental area (VTA) and the ventral striatum/nucleus accumbens (NAc) we found a positive influence of PERIOD 2 (PER2) on transcriptional activation of Maoa using mice mutant in the Per2 gene.	nac	134-137	period circadian clock 2	Mus musculus	182-186
19704445-3	2008	In the mesolimbic dopaminergic reward circuit, including the ventral tegmental area (VTA) and the ventral striatum/nucleus accumbens (NAc) we found a positive influence of PERIOD 2 (PER2) on transcriptional activation of Maoa using mice mutant in the Per2 gene.	nac	134-137	monoamine oxidase A	Mus musculus	221-225
19704445-3	2008	In the mesolimbic dopaminergic reward circuit, including the ventral tegmental area (VTA) and the ventral striatum/nucleus accumbens (NAc) we found a positive influence of PERIOD 2 (PER2) on transcriptional activation of Maoa using mice mutant in the Per2 gene.	nac	134-137	period circadian clock 2	Mus musculus	251-255
18237741-5	2008	Accordingly, we used a yeast surface display library of an entire naive repertoire of human scFv antibodies to select for binding to a NAC peptide.	nac	135-138	immunglobulin heavy chain variable region	Homo sapiens	92-96
19062520-2	2008	We compared the effect of N-acetylcystein (NAC) and alpha-lipoic acid (ALA) on two gelatinases, MMP-2 and MMP-9.	nac	43-46	matrix metallopeptidase 9	Mus musculus	106-111
19062520-4	2008	NAC action for 2-6 hours completely inhibited MMP-2 and MMP-9 activity in both cell lines.	nac	0-3	matrix metallopeptidase 2	Mus musculus	46-51
19062520-4	2008	NAC action for 2-6 hours completely inhibited MMP-2 and MMP-9 activity in both cell lines.	nac	0-3	matrix metallopeptidase 9	Mus musculus	56-61
17560044-4	2007	At the earliest withdrawal period, these behavioral changes were accompanied by elevations in FosB-like immunoreactive staining in the basolateral amygdala (BLA) and nucleus accumbens shell (NAc-Sh) and core (NAc-C).	nac	191-194	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	94-98
18079621-1	2007	The purpose of this study was to evaluate the effectiveness and adverse events of combination chemotherapy with S-1 and docetaxel (DOC) as neo-adjuvant chemotherapy (NAC) for patients with oral squamous cell carcinomas.	nac	166-169	proteasome 26S subunit, non-ATPase 1	Homo sapiens	112-115
18079621-8	2007	The present study suggests that combination chemotherapy with S-1 and DOC is an effective and safe regimen in NAC for oral squamous cell carcinomas.	nac	110-113	proteasome 26S subunit, non-ATPase 1	Homo sapiens	62-65
19704545-1	2007	More than 10% of the plant-specific NAC (NAM, ATAF1/2, CUC2) transcription factors have been predicted to have alpha-helical transmembrane (TM) domain in their C-terminal regions, among which at least three members have been proven to be membrane-associated and play a role in cell cycle control and stress responses.	nac	36-39	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	41-44
19704545-1	2007	More than 10% of the plant-specific NAC (NAM, ATAF1/2, CUC2) transcription factors have been predicted to have alpha-helical transmembrane (TM) domain in their C-terminal regions, among which at least three members have been proven to be membrane-associated and play a role in cell cycle control and stress responses.	nac	36-39	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	46-53
19704545-1	2007	More than 10% of the plant-specific NAC (NAM, ATAF1/2, CUC2) transcription factors have been predicted to have alpha-helical transmembrane (TM) domain in their C-terminal regions, among which at least three members have been proven to be membrane-associated and play a role in cell cycle control and stress responses.	nac	36-39	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	55-59
17983061-11	2007	Her2/neu-positive patients who had undergone NAC with trastuzumab had comparable accuracy for sentinel node biopsy in predicting axillary node status.	nac	45-48	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
17410378-1	2007	The plant-specific NAC (NAM, ATAF1/2, CUC2) transcription factors play regulatory roles in diverse developmental processes and stress responses.	nac	19-22	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	24-27
17410378-1	2007	The plant-specific NAC (NAM, ATAF1/2, CUC2) transcription factors play regulatory roles in diverse developmental processes and stress responses.	nac	19-22	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	29-36
17410378-1	2007	The plant-specific NAC (NAM, ATAF1/2, CUC2) transcription factors play regulatory roles in diverse developmental processes and stress responses.	nac	19-22	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	38-42
17978468-1	2007	The basic disaccharide structure recognized by galectin family members is the lactosamine-like structure Galbeta1-4(3)Glc(NAc).	nac	122-125	Galectin	Caenorhabditis elegans	47-55
17978468-3	2007	Each galectin seems to mediate diverse biological functions due to recognition of different modifications of the basic disaccharide Galbeta1-4(3)Glc(NAc), but there is very little information about which amino acid residue in galectin is responsible for recognizing these modifications.	nac	149-152	Galectin	Caenorhabditis elegans	5-13
17639599-9	2007	In addition, treatment with the ROS scavenger NAC (2 mM) significantly reduced the high glucose-induced phosphorylation of PKC and GRO secretion.	nac	46-49	C-X-C motif chemokine ligand 1	Rattus norvegicus	131-134
17560044-4	2007	At the earliest withdrawal period, these behavioral changes were accompanied by elevations in FosB-like immunoreactive staining in the basolateral amygdala (BLA) and nucleus accumbens shell (NAc-Sh) and core (NAc-C).	nac	209-212	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	94-98
17560044-6	2007	After 5 weeks of withdrawal, FosB staining was only elevated in the NAc-Sh and again correlated positively with elevated cocaine preference but negatively with decreased novelty preference.	nac	68-71	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	29-33
17560044-7	2007	These data indicate that alterations in the expression of FosB-like transcription factors in the NAc can predict the dysregulation of hedonic processing that occurs during protracted withdrawal from cocaine.	nac	97-100	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-62
17157477-4	2007	Tumour grade, Bax expression, apoptotic index and cellular DNA content were significantly correlated with the anti-tumour effects of NAC in univariate analysis.	nac	133-136	BCL2 associated X, apoptosis regulator	Homo sapiens	14-17
17301168-4	2007	We found that NAc and VP hotspots reciprocally modulated Fos expression in each other and that the two hotspots were needed together to enhance sucrose "liking" reactions, essentially cooperating within a single hedonic NAc-VP circuit.	nac	14-17	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-60
16794574-9	2007	Sensitization was associated with increased NR2B expression in the accumbens (NAc) shell and decreased Tyr1472 phosphorylation in the NAc core, as well as increased Ser845 phosphorylation of the GluR1 subunit in prefrontal cortex, NAc core, and shell.	nac	78-81	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	44-48
17333250-4	2007	Here, we studied the effects of simultaneous inhibition of SND1 and its homolog, NAC SECONDARY WALL THICKENING PROMOTING FACTOR1 (NST1), on secondary wall synthesis in fibers.	nac	81-84	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	130-134
17329564-7	2007	Changes in expression were also detected in two NAC domain genes, NAC SECONDARY WALL-PROMOTING FACTOR1 (NST1) and NST2, which have been linked to secondary thickening in the anther endothecium.	nac	48-51	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	104-108
17329564-7	2007	Changes in expression were also detected in two NAC domain genes, NAC SECONDARY WALL-PROMOTING FACTOR1 (NST1) and NST2, which have been linked to secondary thickening in the anther endothecium.	nac	48-51	NAC domain protein 66	Arabidopsis thaliana	114-118
17329564-7	2007	Changes in expression were also detected in two NAC domain genes, NAC SECONDARY WALL-PROMOTING FACTOR1 (NST1) and NST2, which have been linked to secondary thickening in the anther endothecium.	nac	66-69	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	104-108
17329564-7	2007	Changes in expression were also detected in two NAC domain genes, NAC SECONDARY WALL-PROMOTING FACTOR1 (NST1) and NST2, which have been linked to secondary thickening in the anther endothecium.	nac	66-69	NAC domain protein 66	Arabidopsis thaliana	114-118
16904170-10	2007	CONCLUSION: Intravenous administration of MVC as a NAC seems to be well tolerated and beneficial in patients with stage IB2 to IIB cervical cancer.	nac	51-54	mitogen-activated protein kinase 8 interacting protein 2	Homo sapiens	120-123
17143493-6	2007	The TS activity was decreased by NAC with UFT, and the addition of CPA resulted in an increased inhibition of TS activity.	nac	33-36	thymidylate synthetase	Homo sapiens	4-6
17143493-1	2007	The present study assesses the effects of neo-adjuvant chemotherapy (NAC) with uracil and tegafur (UFT) alone vs UFT plus cyclophosphamide (CPA), on the activity of thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) in breast cancer tissues.	nac	69-72	thymidylate synthetase	Homo sapiens	165-185
17143493-7	2007	In contrast, DPD activity was increased by NAC with UFT administration, but its increased activity was significantly inhibited by the addition of CPA.	nac	43-46	dihydropyrimidine dehydrogenase	Homo sapiens	13-16
16875718-5	2006	RESULTS: The response to platinum-based NAC was higher in patients with SNP of XRCC1 R399Q (P=0.015), and there was a significant increased chance of treatment response in women with the G/G genotype (OR 38.0; 95% CI 1.66-870.45; P=0.023).	nac	40-43	X-ray repair cross complementing 1	Homo sapiens	79-84
17233795-1	2007	The ZFHD recognition sequence (ZFHDRS) and NAC recognition sequence (NACRS) play an important role in the dehydration-inducible expression of the Arabidopsisthaliana EARLY RESPONSIVETO DEHYDRATION STRESS 1 (ERD1) gene.	nac	43-46	Clp ATPase	Arabidopsis thaliana	166-205
17233795-1	2007	The ZFHD recognition sequence (ZFHDRS) and NAC recognition sequence (NACRS) play an important role in the dehydration-inducible expression of the Arabidopsisthaliana EARLY RESPONSIVETO DEHYDRATION STRESS 1 (ERD1) gene.	nac	43-46	Clp ATPase	Arabidopsis thaliana	207-211
17233795-7	2007	Using the yeast two-hybrid system, we detected an interaction between ZFHD1 and NACRS-binding NAC proteins.	nac	80-83	zinc finger homeodomain 1	Arabidopsis thaliana	70-75
17233795-8	2007	Moreover, co-over-expression of the ZFHD1 and NAC genes restored the morphological phenotype of the transgenic plants to a near wild-type state and enhanced expression of ERD1 in both Arabidopsis T87 protoplasts and transgenic Arabidopsis plants.	nac	46-49	Clp ATPase	Arabidopsis thaliana	171-175
17237351-3	2007	In this study, we show that plant-specific transcription factors, designated NAC SECONDARY WALL THICKENING PROMOTING FACTOR1 (NST1) and NST3, are key regulators of the formation of secondary walls in woody tissues of Arabidopsis thaliana.	nac	77-80	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	126-130
17237351-3	2007	In this study, we show that plant-specific transcription factors, designated NAC SECONDARY WALL THICKENING PROMOTING FACTOR1 (NST1) and NST3, are key regulators of the formation of secondary walls in woody tissues of Arabidopsis thaliana.	nac	77-80	NAC domain containing protein 12	Arabidopsis thaliana	136-140
16376982-12	2006	The preventive effects of NAC on apoptosis were confirmed by Annexin V staining.	nac	26-29	annexin A5	Rattus norvegicus	61-70
17156375-7	2006	The interaction between NET and alpha-Syn occurred via the NAC domain of alpha-Syn, the region directly responsible for self-aggregation.	nac	59-62	synuclein alpha	Homo sapiens	32-41
17156375-7	2006	The interaction between NET and alpha-Syn occurred via the NAC domain of alpha-Syn, the region directly responsible for self-aggregation.	nac	59-62	synuclein alpha	Homo sapiens	73-82
16875718-9	2006	CONCLUSIONS: Genetic polymorphism of XRCC1 R399Q is associated with response to platinum-based NAC in bulky cervical cancer, and MDR analysis documented association between gene-gene interaction of XRCC1 R399Q and treatment response.	nac	95-98	X-ray repair cross complementing 1	Homo sapiens	37-42
16875718-9	2006	CONCLUSIONS: Genetic polymorphism of XRCC1 R399Q is associated with response to platinum-based NAC in bulky cervical cancer, and MDR analysis documented association between gene-gene interaction of XRCC1 R399Q and treatment response.	nac	95-98	X-ray repair cross complementing 1	Homo sapiens	198-203
17026998-5	2006	The use of antioxidants (NAC) prevented FAC disassembly by blocking paxillin redistribution and FAK dephosphorylation, without abrogating AJ or TJ disruption.	nac	25-28	protein tyrosine kinase 2	Rattus norvegicus	96-99
17139376-5	2006	To address this, we chemically modified fondaparinux to abolish its affinity for antithrombin and analyzed the effect of this non-anticoagulant (NAC)-pentasaccharide on binding of U937 cells to P-selectin in vitro and on inflammation in a murine model of kidney I/R injury.	nac	145-148	selectin P	Homo sapiens	194-204
17014260-1	2006	The involvement of neurotensin (NT) within the nucleus accumbens core (NAC) in behavior has been sparsely investigated.	nac	71-74	neurotensin	Rattus norvegicus	19-30
17103249-3	2006	In our model of TAA-treated rats the use of the anti-inflammatory drug-indomethacin, and the redox-regulating drug-N-acetylcysteine (NAC), significantly attenuated TAA-induced HSP25 expression and evoked morphological changes of recruited ED1+ macrophages.	nac	133-136	heat shock protein family B (small) member 1	Rattus norvegicus	176-181
17098812-4	2006	Here, we show that a membrane-bound NAC (for NAM, ATAF1/2, CUC2) transcription factor, designated NTM1 (for NAC with transmembrane motif1), is activated by proteolytic cleavage through regulated intramembrane proteolysis and mediates cytokinin signaling during cell division in Arabidopsis thaliana.	nac	36-39	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	45-48
17098812-4	2006	Here, we show that a membrane-bound NAC (for NAM, ATAF1/2, CUC2) transcription factor, designated NTM1 (for NAC with transmembrane motif1), is activated by proteolytic cleavage through regulated intramembrane proteolysis and mediates cytokinin signaling during cell division in Arabidopsis thaliana.	nac	36-39	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	50-57
17098812-4	2006	Here, we show that a membrane-bound NAC (for NAM, ATAF1/2, CUC2) transcription factor, designated NTM1 (for NAC with transmembrane motif1), is activated by proteolytic cleavage through regulated intramembrane proteolysis and mediates cytokinin signaling during cell division in Arabidopsis thaliana.	nac	36-39	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	59-63
17098812-4	2006	Here, we show that a membrane-bound NAC (for NAM, ATAF1/2, CUC2) transcription factor, designated NTM1 (for NAC with transmembrane motif1), is activated by proteolytic cleavage through regulated intramembrane proteolysis and mediates cytokinin signaling during cell division in Arabidopsis thaliana.	nac	36-39	NAC with transmembrane motif1	Arabidopsis thaliana	98-102
17098812-4	2006	Here, we show that a membrane-bound NAC (for NAM, ATAF1/2, CUC2) transcription factor, designated NTM1 (for NAC with transmembrane motif1), is activated by proteolytic cleavage through regulated intramembrane proteolysis and mediates cytokinin signaling during cell division in Arabidopsis thaliana.	nac	36-39	NAC with transmembrane motif1	Arabidopsis thaliana	108-137
17114348-3	2006	Here, we demonstrate that the Arabidopsis thaliana NAC (for NAM, ATAF1/2, and CUC2) domain transcription factor, SND1 (for secondary wall-associated NAC domain protein), is a key transcriptional switch regulating secondary wall synthesis in fibers.	nac	51-54	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	60-63
17114348-3	2006	Here, we demonstrate that the Arabidopsis thaliana NAC (for NAM, ATAF1/2, and CUC2) domain transcription factor, SND1 (for secondary wall-associated NAC domain protein), is a key transcriptional switch regulating secondary wall synthesis in fibers.	nac	51-54	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	65-72
17114348-3	2006	Here, we demonstrate that the Arabidopsis thaliana NAC (for NAM, ATAF1/2, and CUC2) domain transcription factor, SND1 (for secondary wall-associated NAC domain protein), is a key transcriptional switch regulating secondary wall synthesis in fibers.	nac	51-54	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	78-82
17114348-3	2006	Here, we demonstrate that the Arabidopsis thaliana NAC (for NAM, ATAF1/2, and CUC2) domain transcription factor, SND1 (for secondary wall-associated NAC domain protein), is a key transcriptional switch regulating secondary wall synthesis in fibers.	nac	51-54	NAC domain containing protein 12	Arabidopsis thaliana	113-117
17014914-6	2006	It was found that the ROI levels were increased by IL-18, and an antioxidant, N-acetyl-l-cystein (NAC), blocked the effect of IL-18 on migration, suggesting the involvement of ROI in the signal transduction of IL-18-enhanced cell migration.	nac	98-101	interleukin 18	Mus musculus	126-131
17014914-6	2006	It was found that the ROI levels were increased by IL-18, and an antioxidant, N-acetyl-l-cystein (NAC), blocked the effect of IL-18 on migration, suggesting the involvement of ROI in the signal transduction of IL-18-enhanced cell migration.	nac	98-101	interleukin 18	Mus musculus	126-131
17108739-0	2006	[A case of advanced rectal carcinoma with multiple lung metastases responding to irinotecan combined with 5-fluorouracil and l-leucovorin (IFL) as neoadjuvant chemotherapy (NAC)].	nac	173-176	interferon alpha 1	Homo sapiens	139-142
17108739-10	2006	Thus, NAC by IFL therapy can be one of the useful treatment approaches for patients with advanced rectal cancer.	nac	6-9	interferon alpha 1	Homo sapiens	13-16
17014260-3	2006	The present study investigated whether NT receptors in the NAC are implicated in learning of spatial information.	nac	59-62	neurotensin	Rattus norvegicus	39-41
16803883-4	2006	We also demonstrated in vitro and in vivo, by Forster resonance energy transfer, that this C-terminal region is required for interaction with FAN (FKBP-associated NAC), a new member of the plant-specific family of NAC transcription factors.	nac	163-166	neutral sphingomyelinase activation associated factor	Homo sapiens	142-145
16546300-4	2006	ASN contained 35-amino acid domain known as non-amyloid beta component of Alzheimer"s disease amyloid (NAC) that is probably responsible for its aggregation and toxicity.	nac	103-106	synuclein alpha	Rattus norvegicus	0-3
16964552-3	2006	Using differential display, we previously determined that alpha nascent polypeptide associated complex (alpha NAC) was identified as a potential target as its protein expression was found to be down-regulated as differentiation progressed in cultured human CD8(+) T cells.	nac	110-113	CD8a molecule	Homo sapiens	257-260
16546300-6	2006	The aim of this study was to determine the effect of brain aging and the role of ASN and NAC peptide on striatal dopamine transporter (DAT) function.	nac	89-92	solute carrier family 6 member 3	Rattus norvegicus	113-133
16546300-6	2006	The aim of this study was to determine the effect of brain aging and the role of ASN and NAC peptide on striatal dopamine transporter (DAT) function.	nac	89-92	solute carrier family 6 member 3	Rattus norvegicus	135-138
16546300-9	2006	ASN and NAC peptide at 10 microM concentration inhibited DAT activity by 30%.	nac	8-11	solute carrier family 6 member 3	Rattus norvegicus	57-60
16713429-7	2006	Treatment with the known anti-oxidant NAC also dose-dependently (0.1-10 mmol/L) restored insulin-induced glucose uptake in the presence of hydrogen peroxide.	nac	38-41	insulin	Homo sapiens	89-96
16806307-10	2006	It is proposed that these allosterically interacting mu and CB1 receptors in the NAc core may represent G-protein coupled heterodimeric receptor complexes.	nac	81-84	cannabinoid receptor 1	Rattus norvegicus	60-63
16806307-1	2006	We examined the occurrence of functional interactions between CB1 cannabinoid and mu opioid receptors in the core of rat nucleus accumbens (NAc core).	nac	140-143	cannabinoid receptor 1	Rattus norvegicus	62-65
16845477-8	2006	In accordance with these results, brm mutants present reduced levels of APETALA2, APETALA3, PISTILLATA and NAC-LIKE, ACTIVATED BY AP3/PI.	nac	107-110	transcription regulatory protein SNF2	Arabidopsis thaliana	34-37
16882008-7	2006	Furthermore, only the constructs encoding the NAC domain of alpha-Syn prevented the co-IPs between full-length alpha-Syn and SERT, in both transfected cells and in rat solubilized lysates isolated from the prefrontal cortex.	nac	46-49	synuclein alpha	Homo sapiens	60-69
16882008-7	2006	Furthermore, only the constructs encoding the NAC domain of alpha-Syn prevented the co-IPs between full-length alpha-Syn and SERT, in both transfected cells and in rat solubilized lysates isolated from the prefrontal cortex.	nac	46-49	synuclein alpha	Homo sapiens	111-120
16882008-7	2006	Furthermore, only the constructs encoding the NAC domain of alpha-Syn prevented the co-IPs between full-length alpha-Syn and SERT, in both transfected cells and in rat solubilized lysates isolated from the prefrontal cortex.	nac	46-49	solute carrier family 6 member 4	Rattus norvegicus	125-129
16786123-1	2006	The present study was designed to clarify the expression and prognostic significance of activated Akt and mTOR in cervical cancer and their correlation with response to neoadjuvant chemotherapy (NAC).	nac	195-198	AKT serine/threonine kinase 1	Homo sapiens	98-101
16786123-1	2006	The present study was designed to clarify the expression and prognostic significance of activated Akt and mTOR in cervical cancer and their correlation with response to neoadjuvant chemotherapy (NAC).	nac	195-198	mechanistic target of rapamycin kinase	Homo sapiens	106-110
16786123-7	2006	The expression of p-mTOR and distant metastasis significantly correlated with the response to NAC (p = 0.0101 and p = 0.0107); however, there was no significant correlation between p-Akt and p-mTOR expression and any of the clinicopathological characteristics of the patients.	nac	94-97	mechanistic target of rapamycin kinase	Homo sapiens	20-24
16516256-5	2006	However, TNT-mediated phosphorylation of either eNOS or Akt was drastically blocked by NAC and PEG-CAT.	nac	87-90	AKT serine/threonine kinase 1	Bos taurus	56-59
16713429-9	2006	Similarly, treatment with 5 micromol/L gliclazide or 10 mmol/L NAC significantly overcome the reduction in insulin-stimulated GLUT4 translocation by hydrogen peroxide (P&lt;.01), whereas 5 micromol/L glibenclamide did not.	nac	63-66	insulin	Homo sapiens	107-114
16713429-9	2006	Similarly, treatment with 5 micromol/L gliclazide or 10 mmol/L NAC significantly overcome the reduction in insulin-stimulated GLUT4 translocation by hydrogen peroxide (P&lt;.01), whereas 5 micromol/L glibenclamide did not.	nac	63-66	solute carrier family 2 member 4	Homo sapiens	126-131
16622419-6	2006	Seven new CENP-A-nucleosome distal (CAD) centromere components (CENP-K, CENP-L, CENP-O, CENP-P, CENP-Q, CENP-R and CENP-S) are identified as assembling on the CENP-A NAC.	nac	166-169	centromere protein A	Homo sapiens	10-16
16703399-14	2006	In addition, the NAc core is one site of action where the mGluR2/3 agonists elicit effects on reward-seeking behavior.	nac	17-20	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	58-64
16622419-7	2006	The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling.	nac	11-14	centromere protein A	Homo sapiens	4-10
16266385-5	2005	RESULTS: Following NAC there was a rapid onset of nasal symptoms together with nasal eosinophilia, and the appearance of IL-5 and IL-13 in lavages between 4 and 8 h. Elevated levels of eotaxin, RANTES, IL-8 and MCP-1 were also detected following allergen challenge.	nac	19-22	C-C motif chemokine ligand 11	Homo sapiens	185-192
16677110-5	2006	These findings were confirmed by the antioxidant NAC and ERK-specific inhibitor PD098059 that blunted decreased SMP30 gene expression and binding activity of sites 3 and 5 by t-BHP in Ac2F cell system.	nac	49-52	regucalcin	Rattus norvegicus	112-117
16298339-4	2006	Angiotensin II increased intracellular ROS in adventitial fibroblasts that was completely inhibited by the free radical scavenger NAC, the NAD(P)H oxidase inhibitor DPI, and transfection of antisense gp91phox oligonucleotides.	nac	130-133	angiotensinogen	Rattus norvegicus	0-14
16298339-4	2006	Angiotensin II increased intracellular ROS in adventitial fibroblasts that was completely inhibited by the free radical scavenger NAC, the NAD(P)H oxidase inhibitor DPI, and transfection of antisense gp91phox oligonucleotides.	nac	130-133	cytochrome b-245 beta chain	Rattus norvegicus	200-208
16298339-6	2006	Angiotensin II rapidly induced phosphorylation of p38 MAPK and JNK, both of which were inhibited by DPI, NAC, antisense gp91phox, and the selective AT1 receptor antagonist, losartan.	nac	105-108	angiotensinogen	Rattus norvegicus	0-14
16298339-6	2006	Angiotensin II rapidly induced phosphorylation of p38 MAPK and JNK, both of which were inhibited by DPI, NAC, antisense gp91phox, and the selective AT1 receptor antagonist, losartan.	nac	105-108	mitogen activated protein kinase 14	Rattus norvegicus	50-53
16298339-6	2006	Angiotensin II rapidly induced phosphorylation of p38 MAPK and JNK, both of which were inhibited by DPI, NAC, antisense gp91phox, and the selective AT1 receptor antagonist, losartan.	nac	105-108	mitogen-activated protein kinase 8	Rattus norvegicus	63-66
16166589-5	2006	Adaphostin/MG-132 lethality as well as mitochondrial damage, down-regulation of Raf/MEK/ERK, and activation of JNK were attenuated by the free-radical scavenger NAC, suggesting that oxidative damage plays a functional role in antileukemic effects.	nac	161-164	zinc fingers and homeoboxes 2	Homo sapiens	80-83
16166589-5	2006	Adaphostin/MG-132 lethality as well as mitochondrial damage, down-regulation of Raf/MEK/ERK, and activation of JNK were attenuated by the free-radical scavenger NAC, suggesting that oxidative damage plays a functional role in antileukemic effects.	nac	161-164	mitogen-activated protein kinase kinase 7	Homo sapiens	84-87
16166589-5	2006	Adaphostin/MG-132 lethality as well as mitochondrial damage, down-regulation of Raf/MEK/ERK, and activation of JNK were attenuated by the free-radical scavenger NAC, suggesting that oxidative damage plays a functional role in antileukemic effects.	nac	161-164	mitogen-activated protein kinase 1	Homo sapiens	88-91
16166589-5	2006	Adaphostin/MG-132 lethality as well as mitochondrial damage, down-regulation of Raf/MEK/ERK, and activation of JNK were attenuated by the free-radical scavenger NAC, suggesting that oxidative damage plays a functional role in antileukemic effects.	nac	161-164	mitogen-activated protein kinase 8	Homo sapiens	111-114
16266385-7	2005	CONCLUSION: This study suggests that a single dose of nasal steroid has the capacity to selectively abolish IL-5 and IL-13 responses following NAC.	nac	143-146	interleukin 5	Homo sapiens	108-112
16266385-7	2005	CONCLUSION: This study suggests that a single dose of nasal steroid has the capacity to selectively abolish IL-5 and IL-13 responses following NAC.	nac	143-146	interleukin 13	Homo sapiens	117-122
16214898-2	2005	We show that expression of chimeric repressors derived from NAC SECONDARY WALL THICKENING PROMOTING FACTOR1 (NST1) and NST2 in Arabidopsis thaliana resulted in an anther dehiscence defect due to loss of secondary wall thickening in anther endothecium.	nac	60-63	NAC (No Apical Meristem) domain transcriptional regulator superfamily protein	Arabidopsis thaliana	109-113
16214898-2	2005	We show that expression of chimeric repressors derived from NAC SECONDARY WALL THICKENING PROMOTING FACTOR1 (NST1) and NST2 in Arabidopsis thaliana resulted in an anther dehiscence defect due to loss of secondary wall thickening in anther endothecium.	nac	60-63	NAC domain protein 66	Arabidopsis thaliana	119-123
15860230-4	2005	Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18.	nac	82-85	corticotropin releasing hormone	Mus musculus	13-16
16313723-14	2005	U0126 markedly reduced AP-1 DNA binding activity induced by Aldo; NAC partly decreased AP-1 activity induced by Aldo.	nac	66-69	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	87-91
15860230-4	2005	Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18.	nac	82-85	interleukin 18	Mus musculus	25-30
15749385-5	2005	NAC and Trolox, cytoplasmic ROS scavengers, abolished the UVB-induced TGF-beta and intracellular ROS, suggesting that UVB-induced ROS are involved in TGF-beta regulation.	nac	0-3	transforming growth factor beta 1	Homo sapiens	70-78
15860230-4	2005	Furthermore, CRH induced IL-18 production could be blocked by N-acetyl-L-cystein (NAC), which suggests that reactive oxygen intermediates (ROI) may be involved in regulating IL-18.	nac	82-85	interleukin 18	Mus musculus	174-179
15680482-9	2005	Ang II markedly augmented intracellular H2O2 production which was decreased by pretreatment with N-acetylcystein (NAC), an anti-oxidant.	nac	114-117	angiotensinogen	Homo sapiens	0-6
15680482-10	2005	Ang II and H2O2 decreased Gax expression dose-dependently and these effects were blocked by administration of both NAC and pyrrolidine dithiocarbamate (PDTC), another anti-oxidant.	nac	115-118	angiotensinogen	Homo sapiens	0-6
15680482-10	2005	Ang II and H2O2 decreased Gax expression dose-dependently and these effects were blocked by administration of both NAC and pyrrolidine dithiocarbamate (PDTC), another anti-oxidant.	nac	115-118	mesenchyme homeobox 2	Homo sapiens	26-29
15680482-11	2005	Ang II and H2O2 induced marked activation of extracellular signal-responsive kinase1/2 (ERK1/2), which was blocked by NAC.	nac	118-121	angiotensinogen	Homo sapiens	0-6
15680482-11	2005	Ang II and H2O2 induced marked activation of extracellular signal-responsive kinase1/2 (ERK1/2), which was blocked by NAC.	nac	118-121	mitogen-activated protein kinase 3	Homo sapiens	88-94
15680482-12	2005	Ang II and H2O2 also activated p38MAPK, and they were blocked by pre-treatment with NAC.	nac	84-87	angiotensinogen	Homo sapiens	0-6
15749385-5	2005	NAC and Trolox, cytoplasmic ROS scavengers, abolished the UVB-induced TGF-beta and intracellular ROS, suggesting that UVB-induced ROS are involved in TGF-beta regulation.	nac	0-3	transforming growth factor beta 1	Homo sapiens	150-158
15769089-5	2005	The hCTM01-NAc-gamma calicheamicin DM amide conjugate, referred to as CMB-401, shows targeted killing of MUC1-expressing cells in vitro and produces pronounced dose-related antitumor effects over an 8-fold dose range against a MUC1-expressing, ovarian xenograft tumor, OvCar-3.	nac	11-14	mucin 1, cell surface associated	Homo sapiens	227-231
15659115-8	2005	Rg1 or NAC prevented GSH reduction and T-SOD activation in substantia nigra, and attenuated the phosphorylations of JNK and c-Jun following MPTP treatment.	nac	7-10	mitogen-activated protein kinase 8	Mus musculus	116-119
15769089-5	2005	The hCTM01-NAc-gamma calicheamicin DM amide conjugate, referred to as CMB-401, shows targeted killing of MUC1-expressing cells in vitro and produces pronounced dose-related antitumor effects over an 8-fold dose range against a MUC1-expressing, ovarian xenograft tumor, OvCar-3.	nac	11-14	mucin 1, cell surface associated	Homo sapiens	105-109
15733082-3	2005	We now report that AD4, the novel low molecular weight thiol antioxidant and the N-acytel cysteine (NAC) related compound, is capable of penetrating the brain and protects neurons in general and especially dopaminergic cells against various OS-generating neurotoxins in tissue cultures.	nac	100-103	presenilin 2	Homo sapiens	19-22
15659115-8	2005	Rg1 or NAC prevented GSH reduction and T-SOD activation in substantia nigra, and attenuated the phosphorylations of JNK and c-Jun following MPTP treatment.	nac	7-10	jun proto-oncogene	Mus musculus	124-129
15589593-2	2005	We examined the association between CA125 regression in neoadjuvant chemotherapy (NAC) and prognosis.	nac	82-85	mucin 16, cell surface associated	Homo sapiens	36-41