PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27816515-0	2017	Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.	pyrrolopyrimidinone	49-68	microtubule affinity regulating kinase 1	Homo sapiens	69-73
25815142-5	2015	Starting from a 2-phenyl quinazolinone hit (compound 1), we discovered the pyrrolopyrimidinone compound 25 (AZ6102), which is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows 5 nM Wnt pathway inhibition in DLD-1 cells.	pyrrolopyrimidinone	75-94	tankyrase	Homo sapiens	135-142
25815142-5	2015	Starting from a 2-phenyl quinazolinone hit (compound 1), we discovered the pyrrolopyrimidinone compound 25 (AZ6102), which is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows 5 nM Wnt pathway inhibition in DLD-1 cells.	pyrrolopyrimidinone	75-94	poly(ADP-ribose) polymerase 1	Homo sapiens	197-201
24872948-3	2014	Mirodenafil is a newly developed pyrrolopyrimidinone compound, which is a potent, reversible, and selective oral PDE5 inhibitor.	pyrrolopyrimidinone	33-52	phosphodiesterase 5A	Homo sapiens	113-117