PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31838771-3 2020 In the last step of glycolysis, the enzyme lactate dehydrogenase A (LDHA) catalyzes the conversion of pyruvate to lactic acid, the accumulation of which contributes to the creation of an acidic tumor microenvironment. Pyruvates 102-110 lactate dehydrogenase A Homo sapiens 43-66 31927141-2 2020 In eukaryotic cells, the pyruvate dehydrogenase complex (PDHC) is negatively regulated by four pyruvate dehydrogenase kinases (PDKs) and two antagonistically acting pyruvate dehydrogenase phosphatases (PDPs). Pyruvates 25-33 pyruvate dehydrogenase kinase 2 Homo sapiens 127-131 31927141-2 2020 In eukaryotic cells, the pyruvate dehydrogenase complex (PDHC) is negatively regulated by four pyruvate dehydrogenase kinases (PDKs) and two antagonistically acting pyruvate dehydrogenase phosphatases (PDPs). Pyruvates 95-103 pyruvate dehydrogenase kinase 2 Homo sapiens 127-131 31927141-2 2020 In eukaryotic cells, the pyruvate dehydrogenase complex (PDHC) is negatively regulated by four pyruvate dehydrogenase kinases (PDKs) and two antagonistically acting pyruvate dehydrogenase phosphatases (PDPs). Pyruvates 95-103 pyruvate dehydrogenase kinase 2 Homo sapiens 127-131 31652354-1 2020 The M2 splice isoform of pyruvate kinase (PKM2) is a key enzyme for generating pyruvate and ATP in the glycolytic pathway, whereas the role of PKM2 in tumorigenesis remains a subject of debate. Pyruvates 25-33 pyruvate kinase M1/2 Homo sapiens 42-46 31652354-1 2020 The M2 splice isoform of pyruvate kinase (PKM2) is a key enzyme for generating pyruvate and ATP in the glycolytic pathway, whereas the role of PKM2 in tumorigenesis remains a subject of debate. Pyruvates 25-33 pyruvate kinase M1/2 Homo sapiens 143-147 31652354-1 2020 The M2 splice isoform of pyruvate kinase (PKM2) is a key enzyme for generating pyruvate and ATP in the glycolytic pathway, whereas the role of PKM2 in tumorigenesis remains a subject of debate. Pyruvates 79-87 pyruvate kinase M1/2 Homo sapiens 42-46 13017836-0 1952 [Effect of insulin in vitro and in vivo on metabolism of pyruvates]. Pyruvates 57-66 insulin Homo sapiens 11-18 31838771-3 2020 In the last step of glycolysis, the enzyme lactate dehydrogenase A (LDHA) catalyzes the conversion of pyruvate to lactic acid, the accumulation of which contributes to the creation of an acidic tumor microenvironment. Pyruvates 102-110 lactate dehydrogenase A Homo sapiens 68-72 32017977-8 2020 Based on the results of the MS data analysis by the MASCOT database search engine, 10 proteins with altered intensity were identified as pyruvate kinase, alpha-enolase, aconitate hydratase, creatine kinase B-type, phosphatidylethanolamine-binding protein 1, 14-3-3 protein eta, guanine nucleotide-binding protein subunit beta-1, dihydropyrimidinase-related protein 2, glutamine synthetase and the neurofilament light polypeptide. Pyruvates 137-145 glutamate-ammonia ligase Rattus norvegicus 368-388 32040844-1 2020 BACKGROUND: The M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2) is one of the key components in the Warburg effect, and an important regulator of cancer cell metabolism. Pyruvates 52-60 pyruvate kinase M1/2 Homo sapiens 69-73 31900478-0 2020 Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages. Pyruvates 0-8 interleukin 10 Mus musculus 57-71 31900478-5 2020 Among them, pyruvate dehydrogenase kinase (PDK)-dependent acute glycolysis was negatively involved in IL-10 production. Pyruvates 12-20 interleukin 10 Mus musculus 102-107 32043619-1 2020 Pyruvate kinase (PK) deficiency is a rare recessive congenital hemolytic anemia caused by mutations in the PKLR gene. Pyruvates 0-8 pyruvate kinase L/R Homo sapiens 107-111 32050040-3 2020 Here we have identified nuclear localization signals (NLSs) of SRSF4 by using a pyruvate kinase fusion system. Pyruvates 80-88 serine and arginine rich splicing factor 4 Homo sapiens 63-68 31863675-3 2020 Here, we describe the chemical proteomic discovery of alpha-chloroacetamide (aCA) compounds that covalently modify cysteine-54 (C54) of the MPC2 subunit of the mitochondrial pyruvate carrier (MPC) complex. Pyruvates 174-182 mitochondrial pyruvate carrier 2 Homo sapiens 140-144 31958319-2 2020 Placenta has abundant expression of (P)RR, and the binding of (P)RR with pyruvate dehydrogenase E1 beta subunit (PDHB) is reported to maintain oxidative metabolism. Pyruvates 73-81 pyruvate dehydrogenase E1 subunit beta Homo sapiens 113-117 32072180-7 2020 We also analyzed the L-type pyruvate kinase (PKLR) promoter sequence to identify the regulatory effect of HNF-1a on PKLR transcription and confirmed the HNF-1a binding site in the PKLR promoter via a chromatin immunoprecipitation assay. Pyruvates 28-36 pyruvate kinase L/R Homo sapiens 45-49 31974143-0 2020 Liver ChREBP Protects Against Fructose-induced Glycogenic Hepatotoxicity by Regulating L-type Pyruvate Kinase. Pyruvates 94-102 MLX interacting protein-like Mus musculus 6-12 31935112-8 2020 Knockdown of TXNIP in bovine oocytes significantly increased glycolysis by increasing the activities of phosphofructokinase (PFK), pyruvate kinase, and lactate dehydrogenase; pyruvate and lactate production; and intracellular ATP level, as well as mitochondrial activity. Pyruvates 131-139 thioredoxin interacting protein Bos taurus 13-18 31823361-2 2020 Pyruvate kinase (PK) catalyzes the last step of glycolysis and exists as four isoenzymes: PKL, PKR, PKM1 and PKM2. Pyruvates 0-8 pyruvate kinase L/R Homo sapiens 90-93 31823361-2 2020 Pyruvate kinase (PK) catalyzes the last step of glycolysis and exists as four isoenzymes: PKL, PKR, PKM1 and PKM2. Pyruvates 0-8 pyruvate kinase L/R Homo sapiens 95-98 31823361-2 2020 Pyruvate kinase (PK) catalyzes the last step of glycolysis and exists as four isoenzymes: PKL, PKR, PKM1 and PKM2. Pyruvates 0-8 pyruvate kinase M1/2 Homo sapiens 109-113 31877353-4 2020 We exemplify this using the test system beta-galactosidase (Bgal) and the oncology target pyruvate kinase 2 (PKM2). Pyruvates 90-98 pyruvate kinase M1/2 Homo sapiens 109-113 31724279-0 2020 p,p"-Dichlorodiphenyltrichloroethane promotes aerobic glycolysis via reactive oxygen species-mediated extracellular signal-regulated kinase/M2 isoform of pyruvate kinase (PKM2) signaling in colorectal cancer cells. Pyruvates 154-162 pyruvate kinase M1/2 Homo sapiens 171-175 31724279-4 2020 We found p,p"-DDT elevated the expression and nucleus translocation of M2 isoform of pyruvate kinase (PKM2), which was responsible for p,p"-DDT-induced enhancement of aerobic glycolysis. Pyruvates 85-93 pyruvate kinase M1/2 Homo sapiens 102-106 32064930-5 2020 LDHA converts pyruvate to lactate in the final step of glycolysis and is often upregulated in cancer. Pyruvates 14-22 lactate dehydrogenase A Homo sapiens 0-4 31988148-1 2020 Pyruvate kinase M2 (PKM2) links metabolic and inflammatory dysfunction in atherosclerotic coronary artery disease; however, its role in Ox-LDL induced macrophage foam cell formation, and inflammation is unknown and therefore presently studied. Pyruvates 0-8 pyruvate kinase, muscle Mus musculus 20-24 31901148-2 2020 The M2 isoform of pyruvate kinase (PKM2) has a key role in catalyzing glycolysis, and PKM2 expression varies even within a single tumor. Pyruvates 18-26 pyruvate kinase M1/2 Homo sapiens 35-39 31901148-2 2020 The M2 isoform of pyruvate kinase (PKM2) has a key role in catalyzing glycolysis, and PKM2 expression varies even within a single tumor. Pyruvates 18-26 pyruvate kinase M1/2 Homo sapiens 86-90 31901577-5 2020 Fry exposed to 1000 ppm CO2 had a higher activity of pyruvate kinase (PK), higher concentrations of pyruvate, acetate, 2-oxoglutarate, phenylalanine, tyrosine, inosine, uracil and uridine, and lower concentrations of anserine and IMP in muscle tissue based on metabolomic analysis. Pyruvates 53-61 pyruvate kinase PKM Oncorhynchus mykiss 70-72 31935112-8 2020 Knockdown of TXNIP in bovine oocytes significantly increased glycolysis by increasing the activities of phosphofructokinase (PFK), pyruvate kinase, and lactate dehydrogenase; pyruvate and lactate production; and intracellular ATP level, as well as mitochondrial activity. Pyruvates 175-183 thioredoxin interacting protein Bos taurus 13-18 31838085-5 2020 AR signaling upregulates DRP1 to form the VDAC-MPC2 complex, increases pyruvate transport into mitochondria, and supports mitochondrial metabolism, including oxidative phosphorylation and lipogenesis. Pyruvates 71-79 androgen receptor Homo sapiens 0-2 31931141-15 2020 Pyruvate carboxylase (PC) and pyruvate dehydrogenase (PDH) are the two main enzymes controlling pyruvate entry to the TCA cycle. Pyruvates 30-38 pyruvate carboxylase Homo sapiens 22-24 31931141-15 2020 Pyruvate carboxylase (PC) and pyruvate dehydrogenase (PDH) are the two main enzymes controlling pyruvate entry to the TCA cycle. Pyruvates 30-38 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 54-57 32058954-3 2020 At the cellular level, BMAL1 suppresses the flexibility of mitochondrial substrate usage and the pyruvate-dependent mitochondrial respiration induced by CIT. Pyruvates 97-105 aryl hydrocarbon receptor nuclear translocator like Homo sapiens 23-28 32058969-4 2020 Prolonged exposure to excess glucose led to hyperactivation of mTORC1 and metabolic acceleration, characterized by higher basal respiration and maximal respiratory capacity, increased energy demand, and enhanced flux through mitochondrial pyruvate metabolism. Pyruvates 239-247 CREB regulated transcription coactivator 1 Mus musculus 63-69 32058969-5 2020 Inhibition of pyruvate transport to the mitochondria decelerated the metabolism of beta-cells chronically exposed to excess glucose and re-established glucose-dependent mTORC1 signaling, disrupting a positive feedback loop for mTORC1 hyperactivation. Pyruvates 14-22 CREB regulated transcription coactivator 1 Mus musculus 169-175 32058969-5 2020 Inhibition of pyruvate transport to the mitochondria decelerated the metabolism of beta-cells chronically exposed to excess glucose and re-established glucose-dependent mTORC1 signaling, disrupting a positive feedback loop for mTORC1 hyperactivation. Pyruvates 14-22 CREB regulated transcription coactivator 1 Mus musculus 227-233 32075767-5 2020 Importantly, this latter event is linked to glycogen-synthase-kinase-3beta (GSK-3beta) hyper-activation, leading, in turn, to impaired recruitment of hexokinase 1 (HK1) to mitochondria, destabilization of mitochondrial-pyruvate-carrier (MPC) complexes, and decreased MPC2 protein levels. Pyruvates 219-227 glycogen synthase kinase 3 beta Homo sapiens 44-74 32075767-5 2020 Importantly, this latter event is linked to glycogen-synthase-kinase-3beta (GSK-3beta) hyper-activation, leading, in turn, to impaired recruitment of hexokinase 1 (HK1) to mitochondria, destabilization of mitochondrial-pyruvate-carrier (MPC) complexes, and decreased MPC2 protein levels. Pyruvates 219-227 glycogen synthase kinase 3 alpha Homo sapiens 76-85 32075767-5 2020 Importantly, this latter event is linked to glycogen-synthase-kinase-3beta (GSK-3beta) hyper-activation, leading, in turn, to impaired recruitment of hexokinase 1 (HK1) to mitochondria, destabilization of mitochondrial-pyruvate-carrier (MPC) complexes, and decreased MPC2 protein levels. Pyruvates 219-227 hexokinase 1 Homo sapiens 150-162 32075767-5 2020 Importantly, this latter event is linked to glycogen-synthase-kinase-3beta (GSK-3beta) hyper-activation, leading, in turn, to impaired recruitment of hexokinase 1 (HK1) to mitochondria, destabilization of mitochondrial-pyruvate-carrier (MPC) complexes, and decreased MPC2 protein levels. Pyruvates 219-227 hexokinase 1 Homo sapiens 164-167 31845497-4 2020 By coupling FDH* and NCD-dependent malic enzyme (ME*), we demonstrated the successful utilization of formate as both CO 2 source and electron donor for reductive carboxylation of pyruvate with a perfect stoichiometry between formate and malate. Pyruvates 179-187 aldehyde dehydrogenase 1 family member L1 Homo sapiens 12-15 32071289-3 2020 Here, we demonstrated high expression of the mitochondrial gatekeeping enzyme, pyruvate dehydrogenase kinase 1 (PDK1), in both clinical samples and cell lines of ovarian cancer. Pyruvates 79-87 pyruvate dehydrogenase kinase 1 Homo sapiens 112-116 31924651-4 2020 Although the tetramer form of PKM2 converts phosphoenolpyruvate to pyruvate, the dimeric form of PKM2 has alternative, nonglycolysis functions as a transcriptional coactivator to enhance the transcription of several proinflammatory cytokines. Pyruvates 55-63 pyruvate kinase, muscle Mus musculus 30-34 31885322-7 2020 This review focuses on these aspects of cyclin D1 pathophysiology, which may be crucial for targeted therapy.Abbreviations: aa, amino acid; AR, androgen receptor; ATM, ataxia telangectasia mutant; ATR, ATM and Rad3-related; CDK, cyclin-dependent kinase; ChREBP, carbohydrate response element binding protein; CIP, CDK-interacting protein; CHK1/2, checkpoint kinase 1/2; CKI, CDK inhibitor; DDR, DNA damage response; DMP1, cyclin D-binding myb-like protein; DSB, double-strand DNA break; DNA-PK, DNA-dependent protein kinase; ER, estrogen receptor; FASN, fatty acid synthase; GSK3beta, glycogen synthase-3beta; HAT, histone acetyltransferase; HDAC, histone deacetylase; HK2, hexokinase 2; HNF4alpha, and hepatocyte nuclear factor 4alpha; HR, homologous recombination; IR, ionizing radiation; KIP, kinase inhibitory protein; MCL, mantle cell lymphoma; NHEJ, non-homologous end-joining; PCAF, p300/CREB binding-associated protein; PGC1alpha, PPARgamma co-activator 1alpha; PEST, proline-glutamic acid-serine-threonine, PK, pyruvate kinase; PPAR, peroxisome proliferator-activated receptor; RB1, retinoblastoma protein; ROS, reactive oxygen species; SRC, steroid receptor coactivator; STAT, signal transducer and activator of transcription; TGFbeta, transforming growth factor beta; UPS, ubiquitin-proteasome system; USP22, ubiquitin-specific peptidase 22; XPO1 (or CRM1) exportin 1. Pyruvates 1020-1028 cyclin D1 Mus musculus 40-49 31874860-5 2020 Conversion from pyruvate to acetate is activated under hypoxic conditions, and ACS recovers carbon that would otherwise be lost from the plant as ethanol. Pyruvates 16-24 acetyl-CoA synthetase Arabidopsis thaliana 79-82 32029721-6 2020 The metabolic switch triggering this global histone hypoacetylation was the induction of pyruvate dehydrogenase kinases (PDK1 and PDK3). Pyruvates 89-97 pyruvate dehydrogenase kinase 1 Homo sapiens 121-125 32029721-6 2020 The metabolic switch triggering this global histone hypoacetylation was the induction of pyruvate dehydrogenase kinases (PDK1 and PDK3). Pyruvates 89-97 pyruvate dehydrogenase kinase 3 Homo sapiens 130-134 32041182-5 2020 Decreased PDH activity and upregulation of PC shuttled more pyruvate to oxaloacetate. Pyruvates 60-68 pyruvate carboxylase Rattus norvegicus 43-45 32041182-8 2020 PC inhibition reduced the glycolytic shift by attenuating Akt-signaling, glycolysis, and restored mitochondrial pyruvate oxidation. Pyruvates 112-120 pyruvate carboxylase Rattus norvegicus 0-2 32033380-8 2020 Our results show the feasibility of monitoring the beta-elimination of KYAT1 by our assay and the results were compared to the previously described beta-elimination assays measuring pyruvate. Pyruvates 182-190 kynurenine aminotransferase 1 Homo sapiens 71-76 32019928-4 2020 Moreover, we find that inflammatory macrophages reroute pyruvate away from pyruvate dehydrogenase (PDH) in an NO-dependent and hypoxia-inducible factor 1alpha (Hif1alpha)-independent manner, thereby promoting glutamine-based anaplerosis. Pyruvates 56-64 hypoxia inducible factor 1, alpha subunit Mus musculus 127-158 32019928-4 2020 Moreover, we find that inflammatory macrophages reroute pyruvate away from pyruvate dehydrogenase (PDH) in an NO-dependent and hypoxia-inducible factor 1alpha (Hif1alpha)-independent manner, thereby promoting glutamine-based anaplerosis. Pyruvates 56-64 hypoxia inducible factor 1, alpha subunit Mus musculus 160-169 32019928-4 2020 Moreover, we find that inflammatory macrophages reroute pyruvate away from pyruvate dehydrogenase (PDH) in an NO-dependent and hypoxia-inducible factor 1alpha (Hif1alpha)-independent manner, thereby promoting glutamine-based anaplerosis. Pyruvates 75-83 hypoxia inducible factor 1, alpha subunit Mus musculus 160-169 31918262-6 2020 Furthermore, exosomal Kras inhibition downregulated transcription factor BACH2/GATA-3 expression in lung tumor tissues by shifting pyruvate/PKM2 dependent metabolism, contributing to a tumor-restraining status. Pyruvates 131-139 KRAS proto-oncogene, GTPase Homo sapiens 22-26 31918262-6 2020 Furthermore, exosomal Kras inhibition downregulated transcription factor BACH2/GATA-3 expression in lung tumor tissues by shifting pyruvate/PKM2 dependent metabolism, contributing to a tumor-restraining status. Pyruvates 131-139 BTB domain and CNC homolog 2 Homo sapiens 73-78 31918262-6 2020 Furthermore, exosomal Kras inhibition downregulated transcription factor BACH2/GATA-3 expression in lung tumor tissues by shifting pyruvate/PKM2 dependent metabolism, contributing to a tumor-restraining status. Pyruvates 131-139 GATA binding protein 3 Homo sapiens 79-85 31991719-11 2020 Prevention of Akt-nitration significantly controlled pyruvate in oxidative phosphorylation by decreasing lactate and increasing pyruvate dehydrogenases activities. Pyruvates 53-61 AKT serine/threonine kinase 1 Homo sapiens 14-17 31991719-11 2020 Prevention of Akt-nitration significantly controlled pyruvate in oxidative phosphorylation by decreasing lactate and increasing pyruvate dehydrogenases activities. Pyruvates 128-136 AKT serine/threonine kinase 1 Homo sapiens 14-17 31564440-5 2020 RNA sequencing data demonstrate a significant increase in the predominant pyruvate uptake transporter, monocarboxylate transporter 1. Pyruvates 74-82 solute carrier family 16 member 1 Homo sapiens 103-132 31907035-1 2020 BACKGROUND: The mitochondrial pyruvate carrier (MPC) plays a central role in energy metabolism by transporting pyruvate across the inner mitochondrial membrane. Pyruvates 30-38 mitochondrial pyruvate carrier Saccharomyces cerevisiae S288C 48-51 31682172-8 2020 Increased AGT expression induced by treatment with pyruvate, a glucose metabolite that does not require SGLT2 for uptake, was not attenuated by CANA. Pyruvates 51-59 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 10-13 32035298-0 2020 Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands. Pyruvates 99-107 pyruvate dehydrogenase kinase 1 Homo sapiens 132-137 31593685-2 2020 Among hMCTs, hMCT1-4 cotransport H+ with monocarboxylates such as pyruvate and l-lactate, implying that these proteins recognize both substrate and H+. Pyruvates 66-74 solute carrier family 16 member 14 Homo sapiens 13-20 31678165-6 2020 Recent studies have shown that Pin1 also binds to a variety of metabolic regulators, such as AMP-activated protein kinase, acetyl CoA carboxylase and pyruvate kinase2, indicating Pin1 to have major impacts on lipid and glucose metabolism in cancer cells. Pyruvates 150-158 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens 31-35 31678165-6 2020 Recent studies have shown that Pin1 also binds to a variety of metabolic regulators, such as AMP-activated protein kinase, acetyl CoA carboxylase and pyruvate kinase2, indicating Pin1 to have major impacts on lipid and glucose metabolism in cancer cells. Pyruvates 150-158 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens 179-183 31928475-6 2020 A new insulin sensitizer that targets the newly identified mitochondrial pyruvate carrier could provide an approach.Expert Opinion: A metabolic approach is needed for the treatment of NASH. Pyruvates 73-81 insulin Homo sapiens 6-13 31928475-7 2020 Clinical studies are underway to determine whether a new insulin sensitizer that targets pyruvate metabolism can impact NASH, T2D, and cardiovascular disease. Pyruvates 89-97 insulin Homo sapiens 57-64 31821485-3 2020 The current study investigates the importance of the two isoenzymes of pyruvate carboxylase (PYC1 and PYC2) and one of the key enzymes of the glyoxylate cycle (ICL1) for growth on glycerol (C3) as a sole carbon source. Pyruvates 71-79 pyruvate carboxylase 1 Saccharomyces cerevisiae S288C 93-97 31821485-3 2020 The current study investigates the importance of the two isoenzymes of pyruvate carboxylase (PYC1 and PYC2) and one of the key enzymes of the glyoxylate cycle (ICL1) for growth on glycerol (C3) as a sole carbon source. Pyruvates 71-79 pyruvate carboxylase 2 Saccharomyces cerevisiae S288C 102-106 31760602-0 2020 Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein Complex. Pyruvates 58-66 egl-9 family hypoxia inducible factor 3 Homo sapiens 37-57 31781893-10 2020 In conclusion, the present findings suggest that skeletal muscle IL-6 regulates markers of lipolysis in VAT in the basal state and pyruvate availability for glyceroneogenesis in VAT with exercise. Pyruvates 131-139 interleukin 6 Mus musculus 65-69 31735334-8 2020 Conversely, compared to HCA, the HCC lesion display increased expression of many oncogenes and the M2 isoform of pyruvate kinase (PKM2), a glycolytic enzyme critical for aerobic glycolysis and tumorigenesis. Pyruvates 113-121 pyruvate kinase M1/2 Homo sapiens 130-134 32003689-11 2020 Butyrate, orexin and melatonin can positively regulate mitochondria via the disinhibition of the pyruvate dehydrogenase complex, leading to increased conversion of pyruvate to acetyl-CoA. Pyruvates 97-105 hypocretin neuropeptide precursor Homo sapiens 10-16 32003689-11 2020 Butyrate, orexin and melatonin can positively regulate mitochondria via the disinhibition of the pyruvate dehydrogenase complex, leading to increased conversion of pyruvate to acetyl-CoA. Pyruvates 164-172 hypocretin neuropeptide precursor Homo sapiens 10-16 31639438-6 2020 Indeed, 6NJ and 6J mitochondria energized with pyruvate or succinate displayed similar rates for H2O2 elimination, quenching ~84% and ~86% of the H2O2, respectively, in the surrounding medium within 30 s. However, inclusion of palmitoyl-CoA, an NNT inhibitor, significantly limited H2O2 degradation by 6NJ mitochondria only (~55% of H2O2 eliminated in 30 s). Pyruvates 47-55 nicotinamide nucleotide transhydrogenase Mus musculus 245-248 31833658-8 2020 BRAF inhibition induced a significant increase in the HP pyruvate-to-lactate conversion in vivo, followed by a reduction of hypoxia. Pyruvates 57-65 B-Raf proto-oncogene, serine/threonine kinase Homo sapiens 0-4 31964840-4 2020 Expression of lactate dehydrogenase A (LDHA), which catalyzes 13C label exchange between pyruvate and lactate, hypoxia-inducible factor-1 (HIF1alpha), and the monocarboxylate transporters MCT1 and MCT4 were quantified using immunohistochemistry and RNA sequencing. Pyruvates 89-97 lactate dehydrogenase A Homo sapiens 14-37 31964840-4 2020 Expression of lactate dehydrogenase A (LDHA), which catalyzes 13C label exchange between pyruvate and lactate, hypoxia-inducible factor-1 (HIF1alpha), and the monocarboxylate transporters MCT1 and MCT4 were quantified using immunohistochemistry and RNA sequencing. Pyruvates 89-97 lactate dehydrogenase A Homo sapiens 39-43 31697642-9 2020 Forced miR-375 expression in rat or human islets increased mRNA levels of pyruvate dehydrogenase kinase-4, but decreased those of pyruvate carboxylase and malate dehydrogenase1. Pyruvates 74-82 microRNA 375 Rattus norvegicus 7-14 31641207-0 2020 A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism. Pyruvates 107-115 lysine demethylase 5A Homo sapiens 8-13 31641207-0 2020 A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism. Pyruvates 107-115 mitochondrial pyruvate carrier 1 Homo sapiens 14-19 31641207-4 2020 Both in vitro and in vivo models were used to determine biologic impacts of MPC-1 and KDM5A on PDA and mitochondrial pyruvate metabolism, and the mechanism underling reduced MPC-1 expression in PDA. Pyruvates 117-125 mitochondrial pyruvate carrier 1 Homo sapiens 76-81 31641207-4 2020 Both in vitro and in vivo models were used to determine biologic impacts of MPC-1 and KDM5A on PDA and mitochondrial pyruvate metabolism, and the mechanism underling reduced MPC-1 expression in PDA. Pyruvates 117-125 lysine demethylase 5A Homo sapiens 86-91 31641207-7 2020 Re-expression of MPC-1 stimulated the mitochondrial pyruvate metabolism and inhibited glycolysis, while MPC-1-specific inhibitor UK5099 attenuated these effects. Pyruvates 52-60 mitochondrial pyruvate carrier 1 Homo sapiens 17-22 31641207-11 2020 KDM5A/MPC-1 signaling promoted PDA growth, invasion, migration, and stemness via inhibiting mitochondrial pyruvate metabolism. Pyruvates 106-114 lysine demethylase 5A Homo sapiens 0-5 31641207-11 2020 KDM5A/MPC-1 signaling promoted PDA growth, invasion, migration, and stemness via inhibiting mitochondrial pyruvate metabolism. Pyruvates 106-114 mitochondrial pyruvate carrier 1 Homo sapiens 6-11 31654802-10 2020 Our data connects a constitutive expression of HIF-1alpha in response to FA, to the inhibition of pyruvate decarboxylation through up-regulation of PDK-1 and phosphorylation of Pyruvate Dehydrogenase E1alpha subunit. Pyruvates 98-106 hypoxia inducible factor 1 subunit alpha Homo sapiens 47-57 31654802-10 2020 Our data connects a constitutive expression of HIF-1alpha in response to FA, to the inhibition of pyruvate decarboxylation through up-regulation of PDK-1 and phosphorylation of Pyruvate Dehydrogenase E1alpha subunit. Pyruvates 98-106 pyruvate dehydrogenase kinase 1 Homo sapiens 148-153 31654802-10 2020 Our data connects a constitutive expression of HIF-1alpha in response to FA, to the inhibition of pyruvate decarboxylation through up-regulation of PDK-1 and phosphorylation of Pyruvate Dehydrogenase E1alpha subunit. Pyruvates 177-185 hypoxia inducible factor 1 subunit alpha Homo sapiens 47-57 31891638-11 2019 Protein levels of pyruvate:NADP+ oxidoreductase, a key enzyme for anaerobic synthesis of acetyl-CoA, which serves as a C2 donor for fatty acids, showed a 1.68-fold increase under hypoxic conditions, whereas those of pyruvate dehydrogenase subunits showed a 0.77-0.81-fold decrease. Pyruvates 18-26 hydroxysteroid 17-beta dehydrogenase 6 Homo sapiens 33-47 31891638-11 2019 Protein levels of pyruvate:NADP+ oxidoreductase, a key enzyme for anaerobic synthesis of acetyl-CoA, which serves as a C2 donor for fatty acids, showed a 1.68-fold increase under hypoxic conditions, whereas those of pyruvate dehydrogenase subunits showed a 0.77-0.81-fold decrease. Pyruvates 216-224 hydroxysteroid 17-beta dehydrogenase 6 Homo sapiens 33-47 31893043-2 2019 Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic cancer remains controversial. Pyruvates 0-8 pyruvate kinase, muscle Mus musculus 44-48 31893043-8 2019 The serine biosynthesis pathway partially contributed to pyruvate production during PKM1/2 knockdown: knockout of phosphoglycerate dehydrogenase in this pathway decreased pyruvate production from glucose. Pyruvates 57-65 pyruvate kinase, muscle Mus musculus 84-90 31893043-8 2019 The serine biosynthesis pathway partially contributed to pyruvate production during PKM1/2 knockdown: knockout of phosphoglycerate dehydrogenase in this pathway decreased pyruvate production from glucose. Pyruvates 171-179 pyruvate kinase, muscle Mus musculus 84-90 31893043-15 2019 Investigating several alternative sources of pyruvate identified cysteine catabolism for pyruvate production during PKM1/2 knockdown. Pyruvates 45-53 pyruvate kinase, muscle Mus musculus 116-122 31893043-15 2019 Investigating several alternative sources of pyruvate identified cysteine catabolism for pyruvate production during PKM1/2 knockdown. Pyruvates 89-97 pyruvate kinase, muscle Mus musculus 116-122 31712311-2 2019 Here we show that in the highly lethal brain tumor glioblastoma (GBM), mechanistic target of rapamycin complex 2 (mTORC2), a critical core component of the growth factor signaling system, couples acetyl-CoA production with nuclear translocation of histone-modifying enzymes including pyruvate dehydrogenase (PDH) and class IIa histone deacetylases (HDACs) to globally alter histone acetylation. Pyruvates 284-292 CREB regulated transcription coactivator 2 Mus musculus 114-120 31921691-3 2019 Lactate dehydrogenase A (LDHA) promotes glycolysis process by catalyzing the conversion of pyruvate to lactate. Pyruvates 91-99 lactate dehydrogenase A Homo sapiens 0-23 31851938-4 2019 Sirt6+/- results in significantly reduced PPARalpha-induced beta-oxidation and its metabolites and reduced alanine and lactate levels, while inducing pyruvate oxidation. Pyruvates 150-158 sirtuin 6 Mus musculus 0-5 31851938-4 2019 Sirt6+/- results in significantly reduced PPARalpha-induced beta-oxidation and its metabolites and reduced alanine and lactate levels, while inducing pyruvate oxidation. Pyruvates 150-158 peroxisome proliferator activated receptor alpha Mus musculus 42-51 31851938-5 2019 Reciprocally, starved SIRT6 transgenic mice show increased pyruvate, acetylcarnitine, and glycerol levels and significantly induce beta-oxidation genes in a PPARalpha-dependent manner. Pyruvates 59-67 sirtuin 6 Mus musculus 22-27 31921691-3 2019 Lactate dehydrogenase A (LDHA) promotes glycolysis process by catalyzing the conversion of pyruvate to lactate. Pyruvates 91-99 lactate dehydrogenase A Homo sapiens 25-29 31825824-2 2019 We recently observed a pyruvate kinase liver isoform (PKL) phosphorylation site at S113 that correlates with insulin resistance in rats on a 3 day high-fat diet (HFD) and suggests additional control points for PKL activity. Pyruvates 23-31 pyruvate kinase L/R Rattus norvegicus 54-57 31825824-2 2019 We recently observed a pyruvate kinase liver isoform (PKL) phosphorylation site at S113 that correlates with insulin resistance in rats on a 3 day high-fat diet (HFD) and suggests additional control points for PKL activity. Pyruvates 23-31 pyruvate kinase L/R Rattus norvegicus 210-213 31804482-2 2019 Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH that catalyzes the interconversion between pyruvate and lactate. Pyruvates 187-195 aurora kinase A Homo sapiens 21-29 31804482-2 2019 Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH that catalyzes the interconversion between pyruvate and lactate. Pyruvates 187-195 lactate dehydrogenase B Homo sapiens 73-96 31804482-2 2019 Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH that catalyzes the interconversion between pyruvate and lactate. Pyruvates 187-195 lactate dehydrogenase B Homo sapiens 98-102 31804482-2 2019 Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH that catalyzes the interconversion between pyruvate and lactate. Pyruvates 187-195 lactate dehydrogenase B Homo sapiens 98-101 31804482-3 2019 Aurora-A-mediated phosphorylation of LDHB serine 162 significantly increases its activity in reducing pyruvate to lactate, which efficiently promotes NAD+ regeneration, glycolytic flux, lactate production and bio-synthesis with glycolytic intermediates. Pyruvates 102-110 aurora kinase A Homo sapiens 0-8 31804603-5 2019 C-Myc downregulation decreased the expression of lactate dehydrogenase A, the enzyme catalyzing the conversion of pyruvate to lactate. Pyruvates 114-122 MYC proto-oncogene, bHLH transcription factor Homo sapiens 0-5 31804603-5 2019 C-Myc downregulation decreased the expression of lactate dehydrogenase A, the enzyme catalyzing the conversion of pyruvate to lactate. Pyruvates 114-122 lactate dehydrogenase A Homo sapiens 49-72 31598701-0 2019 Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT-NAD+-SIRT1 pathway. Pyruvates 10-18 nicotinamide phosphoribosyltransferase Homo sapiens 100-105 31598701-0 2019 Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT-NAD+-SIRT1 pathway. Pyruvates 10-18 sirtuin 1 Homo sapiens 111-116 31598701-5 2019 Pyruvate represses histone gene expression by inducing the expression of NAD+ biosynthesis enzyme, nicotinamide phosphoribosyltransferase (NAMPT) via myocyte enhancer factor 2C (MEF2C), which then increases NAD+ levels and activates the histone deacetylase activity of SIRT1. Pyruvates 0-8 nicotinamide phosphoribosyltransferase Homo sapiens 99-137 31598701-5 2019 Pyruvate represses histone gene expression by inducing the expression of NAD+ biosynthesis enzyme, nicotinamide phosphoribosyltransferase (NAMPT) via myocyte enhancer factor 2C (MEF2C), which then increases NAD+ levels and activates the histone deacetylase activity of SIRT1. Pyruvates 0-8 nicotinamide phosphoribosyltransferase Homo sapiens 139-144 31598701-5 2019 Pyruvate represses histone gene expression by inducing the expression of NAD+ biosynthesis enzyme, nicotinamide phosphoribosyltransferase (NAMPT) via myocyte enhancer factor 2C (MEF2C), which then increases NAD+ levels and activates the histone deacetylase activity of SIRT1. Pyruvates 0-8 myocyte enhancer factor 2C Homo sapiens 150-176 31598701-5 2019 Pyruvate represses histone gene expression by inducing the expression of NAD+ biosynthesis enzyme, nicotinamide phosphoribosyltransferase (NAMPT) via myocyte enhancer factor 2C (MEF2C), which then increases NAD+ levels and activates the histone deacetylase activity of SIRT1. Pyruvates 0-8 myocyte enhancer factor 2C Homo sapiens 178-183 31598701-5 2019 Pyruvate represses histone gene expression by inducing the expression of NAD+ biosynthesis enzyme, nicotinamide phosphoribosyltransferase (NAMPT) via myocyte enhancer factor 2C (MEF2C), which then increases NAD+ levels and activates the histone deacetylase activity of SIRT1. Pyruvates 0-8 sirtuin 1 Homo sapiens 269-274 31598701-6 2019 Chromatin immunoprecipitation analysis indicates that pyruvate enhances SIRT1 binding at histone gene promoters where it reduces histone acetylation. Pyruvates 54-62 sirtuin 1 Homo sapiens 72-77 32010559-7 2019 For different TNM stages, the pyruvate content (P<0.001) and lactate content (P<0.001) in the II/III/IV stage cancer tissues were significantly higher than those in the stage I cancer tissues. Pyruvates 30-38 teneurin transmembrane protein 1 Homo sapiens 14-17 31582221-2 2019 Pyruvate dehydrogenase (PDH) is a metabolic enzyme that converts pyruvate into acetyl-CoA, connecting glycolysis to the TCA cycle, thus regulating cellular energy metabolism. Pyruvates 65-73 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 0-22 31582221-2 2019 Pyruvate dehydrogenase (PDH) is a metabolic enzyme that converts pyruvate into acetyl-CoA, connecting glycolysis to the TCA cycle, thus regulating cellular energy metabolism. Pyruvates 65-73 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 24-27 31804482-3 2019 Aurora-A-mediated phosphorylation of LDHB serine 162 significantly increases its activity in reducing pyruvate to lactate, which efficiently promotes NAD+ regeneration, glycolytic flux, lactate production and bio-synthesis with glycolytic intermediates. Pyruvates 102-110 lactate dehydrogenase B Homo sapiens 37-41 31804482-4 2019 Mechanistically, LDHB serine 162 phosphorylation relieves its substrate inhibition effect by pyruvate, resulting in remarkable elevation in the conversions of pyruvate and NADH to lactate and NAD+. Pyruvates 93-101 lactate dehydrogenase B Homo sapiens 17-21 31804482-4 2019 Mechanistically, LDHB serine 162 phosphorylation relieves its substrate inhibition effect by pyruvate, resulting in remarkable elevation in the conversions of pyruvate and NADH to lactate and NAD+. Pyruvates 159-167 lactate dehydrogenase B Homo sapiens 17-21 31747582-4 2019 In contrast to in vitro-activated T cells, which display hallmarks of Warburg metabolism, physiologically activated CD8+ T cells displayed greater rates of oxidative metabolism, higher bioenergetic capacity, differential use of pyruvate, and prominent flow of 13C-glucose carbon to anabolic pathways, including nucleotide and serine biosynthesis. Pyruvates 228-236 CD8a molecule Homo sapiens 116-119 31819487-2 2019 Pyruvate dehydrogenase E1 alpha subunit (PDHA1) is an important prerequisite for OXPHOS. Pyruvates 0-8 pyruvate dehydrogenase E1 subunit alpha 1 Homo sapiens 41-46 31606382-5 2019 Mitochondrial pyruvate carrier 2 (MPC2) mediates pyruvate transport from the cytoplasm to the mitochondrial matrix, which determines the cellular energy supply and cell survival. Pyruvates 14-22 mitochondrial pyruvate carrier 2 Homo sapiens 34-38 31602208-11 2019 Puerarin upregulated peroxisome proliferator-activated receptor alpha (PPARalpha) and its downstream target genes nuclear respiratory factor 1, FOS proto-oncogene, YY1 transcription factor, acetyl-coenzyme A carboxylase a, Fas cell surface death receptor, L-type pyruvate kinase and acetyl-coenzyme A dehydrogenase medium chain in myocardial cells from rats with chronic heart failure. Pyruvates 263-271 peroxisome proliferator activated receptor alpha Rattus norvegicus 71-80 31880514-2 2019 The conversion of phosphoenolpyruvate (PEP) to pyruvate can be down regulated by the re-expression of the embryonic isoform 2 of pyruvate kinase (PKM2). Pyruvates 29-37 pyruvate kinase M1/2 Homo sapiens 146-150 31824549-8 2019 The deficiency of thiamine in Gmpgl1 mutant led to reduced activities of the pyruvate dehydrogenase (PDH) and pyruvate decarboxylase (PDC), and decreased contents of six amino acids as compared to that in the wild type plants. Pyruvates 77-85 proline dehydrogenase Glycine max 101-104 31636306-5 2019 In this study, we demonstrate that the glycolytic enzyme pyruvate kinase 2 (PKM2) is required for sprouting angiogenesis in vitro and in vivo through the regulation of endothelial cell-junction dynamics and collective migration. Pyruvates 57-65 pyruvate kinase M1/2 Homo sapiens 76-80 31576870-3 2019 We probe the reactivity of this species by NMR and DFT and upon reaction with sodium pyruvate establish the formation of two isomers of [Ir(H)2(eta2-pyruvate)(DMSO)(IMes)]. Pyruvates 78-93 DNA polymerase iota Homo sapiens 144-148 31648290-6 2019 In this paper, we demonstrate the efficient recruitment of pyruvate decarboxylase (Pdc1) and alcohol dehydrogenase (Adh1) fermentation enzymes into the viral replication compartment. Pyruvates 59-67 indolepyruvate decarboxylase 1 Saccharomyces cerevisiae S288C 83-87 31648290-6 2019 In this paper, we demonstrate the efficient recruitment of pyruvate decarboxylase (Pdc1) and alcohol dehydrogenase (Adh1) fermentation enzymes into the viral replication compartment. Pyruvates 59-67 alcohol dehydrogenase 1A (class I), alpha polypeptide Homo sapiens 116-120 31618280-1 2019 Pyruvate Kinase Deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene, which encodes the erythroid specific Pyruvate Kinase enzyme. Pyruvates 0-8 protein kinase D1 Homo sapiens 28-31 31618280-1 2019 Pyruvate Kinase Deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene, which encodes the erythroid specific Pyruvate Kinase enzyme. Pyruvates 0-8 pyruvate kinase L/R Homo sapiens 98-102 31615527-3 2019 In this study, mitochondrial pyruvate transporter gene (MPC1) or the essential gene for mitophagy (ATG32) was knocked-out to repress the mitochondrial metabolism and improve the production of pyruvate-derived chemical in S. cerevisiae. Pyruvates 29-37 pyruvate transporter MPC1 Saccharomyces cerevisiae S288C 56-60 31615527-3 2019 In this study, mitochondrial pyruvate transporter gene (MPC1) or the essential gene for mitophagy (ATG32) was knocked-out to repress the mitochondrial metabolism and improve the production of pyruvate-derived chemical in S. cerevisiae. Pyruvates 192-200 pyruvate transporter MPC1 Saccharomyces cerevisiae S288C 56-60 31615527-3 2019 In this study, mitochondrial pyruvate transporter gene (MPC1) or the essential gene for mitophagy (ATG32) was knocked-out to repress the mitochondrial metabolism and improve the production of pyruvate-derived chemical in S. cerevisiae. Pyruvates 192-200 mitophagy protein ATG32 Saccharomyces cerevisiae S288C 99-104 31594538-4 2019 RESULTS: Here, we present data suggesting that LSH regulates p53 in cis through two pathways: prevention proteasomal degradation through its deubiquitination, which is achieved by reducing the lysine 11-linked, lysine 48-linked polyubiquitin chains (K11 and K48) on p53; and revival of the transcriptional activity of p53 by forming a complex with PKM2 (pyruvate kinase 2). Pyruvates 354-362 helicase, lymphoid specific Homo sapiens 47-50 31594538-4 2019 RESULTS: Here, we present data suggesting that LSH regulates p53 in cis through two pathways: prevention proteasomal degradation through its deubiquitination, which is achieved by reducing the lysine 11-linked, lysine 48-linked polyubiquitin chains (K11 and K48) on p53; and revival of the transcriptional activity of p53 by forming a complex with PKM2 (pyruvate kinase 2). Pyruvates 354-362 tumor protein p53 Homo sapiens 61-64 31565219-7 2019 Increased phosphofructokinase expression was observed in ERalpha-/- and ERalphabeta-/- mice, whereas increased pyruvate kinase isozyme M2 and pyruvate dehydrogenase expression was observed in ERbeta-/- and ERalphabeta-/- mice. Pyruvates 111-119 estrogen receptor 2 (beta) Mus musculus 192-198 31565219-7 2019 Increased phosphofructokinase expression was observed in ERalpha-/- and ERalphabeta-/- mice, whereas increased pyruvate kinase isozyme M2 and pyruvate dehydrogenase expression was observed in ERbeta-/- and ERalphabeta-/- mice. Pyruvates 142-150 estrogen receptor 2 (beta) Mus musculus 192-198 31880514-2 2019 The conversion of phosphoenolpyruvate (PEP) to pyruvate can be down regulated by the re-expression of the embryonic isoform 2 of pyruvate kinase (PKM2). Pyruvates 47-55 pyruvate kinase M1/2 Homo sapiens 146-150 31549019-2 2019 One of the putative alanine aminotransferases genes, At3g08860, was attributed the function of alanine:glyoxylate aminotransferase/beta-alanine:pyruvate aminotransferase based on the analysis of gene expression networks and homology to other beta-alanine aminotransferases in plants. Pyruvates 144-152 alanine:glyoxylate aminotransferase Arabidopsis thaliana 95-130 31550253-10 2019 In addition, pyruvate dehydrogenase activity was reduced, accompanied by 10-15-fold increased gene expression of its regulator pyruvate dehydrogenase kinase 4 compared to control, suggesting reduced entry of pyruvate into the TCA cycle. Pyruvates 13-21 pyruvate dehydrogenase kinase 4 Rattus norvegicus 127-158 31550253-11 2019 Indeed, the NADPH-generating enzyme malic enzyme 1 (ME1) catalysing production of pyruvate from malate, was increased 13-fold at the gene expression level. Pyruvates 82-90 malic enzyme 1 Rattus norvegicus 36-50 31550253-11 2019 Indeed, the NADPH-generating enzyme malic enzyme 1 (ME1) catalysing production of pyruvate from malate, was increased 13-fold at the gene expression level. Pyruvates 82-90 malic enzyme 1 Rattus norvegicus 52-55 31632919-0 2019 Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis. Pyruvates 100-108 pyruvate kinase M1/2 Homo sapiens 119-123 31632919-3 2019 Pyruvate kinase 2 (PKM2), the last rate-limiting enzyme of glycolysis, is known to regulate aerobic glycolysis, and considered as a novel cancer therapeutic target. Pyruvates 0-8 pyruvate kinase M1/2 Homo sapiens 19-23 31632919-6 2019 MCL, the active metabolic form of DMAMCL, selectively binding to monomeric PKM2 and promoting its tetramerization, was also found to improve the pyruvate kinase activity of PKM2 in GBM cells. Pyruvates 145-153 pyruvate kinase M1/2 Homo sapiens 173-177