PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
13017836-0	1952	[Effect of insulin in vitro and in vivo on metabolism of pyruvates].	Pyruvates	57-66	insulin	Homo sapiens	11-18
31927141-2	2020	In eukaryotic cells, the pyruvate dehydrogenase complex (PDHC) is negatively regulated by four pyruvate dehydrogenase kinases (PDKs) and two antagonistically acting pyruvate dehydrogenase phosphatases (PDPs).	Pyruvates	25-33	pyruvate dehydrogenase kinase 2	Homo sapiens	127-131
31927141-2	2020	In eukaryotic cells, the pyruvate dehydrogenase complex (PDHC) is negatively regulated by four pyruvate dehydrogenase kinases (PDKs) and two antagonistically acting pyruvate dehydrogenase phosphatases (PDPs).	Pyruvates	95-103	pyruvate dehydrogenase kinase 2	Homo sapiens	127-131
31927141-2	2020	In eukaryotic cells, the pyruvate dehydrogenase complex (PDHC) is negatively regulated by four pyruvate dehydrogenase kinases (PDKs) and two antagonistically acting pyruvate dehydrogenase phosphatases (PDPs).	Pyruvates	95-103	pyruvate dehydrogenase kinase 2	Homo sapiens	127-131
31838771-3	2020	In the last step of glycolysis, the enzyme lactate dehydrogenase A (LDHA) catalyzes the conversion of pyruvate to lactic acid, the accumulation of which contributes to the creation of an acidic tumor microenvironment.	Pyruvates	102-110	lactate dehydrogenase A	Homo sapiens	43-66
31838771-3	2020	In the last step of glycolysis, the enzyme lactate dehydrogenase A (LDHA) catalyzes the conversion of pyruvate to lactic acid, the accumulation of which contributes to the creation of an acidic tumor microenvironment.	Pyruvates	102-110	lactate dehydrogenase A	Homo sapiens	68-72
31652354-1	2020	The M2 splice isoform of pyruvate kinase (PKM2) is a key enzyme for generating pyruvate and ATP in the glycolytic pathway, whereas the role of PKM2 in tumorigenesis remains a subject of debate.	Pyruvates	25-33	pyruvate kinase M1/2	Homo sapiens	42-46
31652354-1	2020	The M2 splice isoform of pyruvate kinase (PKM2) is a key enzyme for generating pyruvate and ATP in the glycolytic pathway, whereas the role of PKM2 in tumorigenesis remains a subject of debate.	Pyruvates	25-33	pyruvate kinase M1/2	Homo sapiens	143-147
31652354-1	2020	The M2 splice isoform of pyruvate kinase (PKM2) is a key enzyme for generating pyruvate and ATP in the glycolytic pathway, whereas the role of PKM2 in tumorigenesis remains a subject of debate.	Pyruvates	79-87	pyruvate kinase M1/2	Homo sapiens	42-46
32050040-3	2020	Here we have identified nuclear localization signals (NLSs) of SRSF4 by using a pyruvate kinase fusion system.	Pyruvates	80-88	serine and arginine rich splicing factor 4	Homo sapiens	63-68
31900478-0	2020	Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages.	Pyruvates	0-8	interleukin 10	Mus musculus	57-71
31900478-5	2020	Among them, pyruvate dehydrogenase kinase (PDK)-dependent acute glycolysis was negatively involved in IL-10 production.	Pyruvates	12-20	interleukin 10	Mus musculus	102-107
32040844-1	2020	BACKGROUND: The M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2) is one of the key components in the Warburg effect, and an important regulator of cancer cell metabolism.	Pyruvates	52-60	pyruvate kinase M1/2	Homo sapiens	69-73
32043619-1	2020	Pyruvate kinase (PK) deficiency is a rare recessive congenital hemolytic anemia caused by mutations in the PKLR gene.	Pyruvates	0-8	pyruvate kinase L/R	Homo sapiens	107-111
32017977-8	2020	Based on the results of the MS data analysis by the MASCOT database search engine, 10 proteins with altered intensity were identified as pyruvate kinase, alpha-enolase, aconitate hydratase, creatine kinase B-type, phosphatidylethanolamine-binding protein 1, 14-3-3 protein eta, guanine nucleotide-binding protein subunit beta-1, dihydropyrimidinase-related protein 2, glutamine synthetase and the neurofilament light polypeptide.	Pyruvates	137-145	glutamate-ammonia ligase	Rattus norvegicus	368-388
31935112-8	2020	Knockdown of TXNIP in bovine oocytes significantly increased glycolysis by increasing the activities of phosphofructokinase (PFK), pyruvate kinase, and lactate dehydrogenase; pyruvate and lactate production; and intracellular ATP level, as well as mitochondrial activity.	Pyruvates	131-139	thioredoxin interacting protein	Bos taurus	13-18
31823361-2	2020	Pyruvate kinase (PK) catalyzes the last step of glycolysis and exists as four isoenzymes: PKL, PKR, PKM1 and PKM2.	Pyruvates	0-8	pyruvate kinase L/R	Homo sapiens	90-93
31823361-2	2020	Pyruvate kinase (PK) catalyzes the last step of glycolysis and exists as four isoenzymes: PKL, PKR, PKM1 and PKM2.	Pyruvates	0-8	pyruvate kinase L/R	Homo sapiens	95-98
31823361-2	2020	Pyruvate kinase (PK) catalyzes the last step of glycolysis and exists as four isoenzymes: PKL, PKR, PKM1 and PKM2.	Pyruvates	0-8	pyruvate kinase M1/2	Homo sapiens	109-113
31958319-2	2020	Placenta has abundant expression of (P)RR, and the binding of (P)RR with pyruvate dehydrogenase E1 beta subunit (PDHB) is reported to maintain oxidative metabolism.	Pyruvates	73-81	pyruvate dehydrogenase E1 subunit beta	Homo sapiens	113-117
32072180-7	2020	We also analyzed the L-type pyruvate kinase (PKLR) promoter sequence to identify the regulatory effect of HNF-1a on PKLR transcription and confirmed the HNF-1a binding site in the PKLR promoter via a chromatin immunoprecipitation assay.	Pyruvates	28-36	pyruvate kinase L/R	Homo sapiens	45-49
31974143-0	2020	Liver ChREBP Protects Against Fructose-induced Glycogenic Hepatotoxicity by Regulating L-type Pyruvate Kinase.	Pyruvates	94-102	MLX interacting protein-like	Mus musculus	6-12
31863675-3	2020	Here, we describe the chemical proteomic discovery of alpha-chloroacetamide (aCA) compounds that covalently modify cysteine-54 (C54) of the MPC2 subunit of the mitochondrial pyruvate carrier (MPC) complex.	Pyruvates	174-182	mitochondrial pyruvate carrier 2	Homo sapiens	140-144
31935112-8	2020	Knockdown of TXNIP in bovine oocytes significantly increased glycolysis by increasing the activities of phosphofructokinase (PFK), pyruvate kinase, and lactate dehydrogenase; pyruvate and lactate production; and intracellular ATP level, as well as mitochondrial activity.	Pyruvates	175-183	thioredoxin interacting protein	Bos taurus	13-18
31901577-5	2020	Fry exposed to 1000 ppm CO2 had a higher activity of pyruvate kinase (PK), higher concentrations of pyruvate, acetate, 2-oxoglutarate, phenylalanine, tyrosine, inosine, uracil and uridine, and lower concentrations of anserine and IMP in muscle tissue based on metabolomic analysis.	Pyruvates	53-61	pyruvate kinase PKM	Oncorhynchus mykiss	70-72
32035298-0	2020	Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands.	Pyruvates	99-107	pyruvate dehydrogenase kinase 1	Homo sapiens	132-137
31877353-4	2020	We exemplify this using the test system beta-galactosidase (Bgal) and the oncology target pyruvate kinase 2 (PKM2).	Pyruvates	90-98	pyruvate kinase M1/2	Homo sapiens	109-113
31988148-1	2020	Pyruvate kinase M2 (PKM2) links metabolic and inflammatory dysfunction in atherosclerotic coronary artery disease; however, its role in Ox-LDL induced macrophage foam cell formation, and inflammation is unknown and therefore presently studied.	Pyruvates	0-8	pyruvate kinase, muscle	Mus musculus	20-24
31724279-0	2020	p,p"-Dichlorodiphenyltrichloroethane promotes aerobic glycolysis via reactive oxygen species-mediated extracellular signal-regulated kinase/M2 isoform of pyruvate kinase (PKM2) signaling in colorectal cancer cells.	Pyruvates	154-162	pyruvate kinase M1/2	Homo sapiens	171-175
31724279-4	2020	We found p,p"-DDT elevated the expression and nucleus translocation of M2 isoform of pyruvate kinase (PKM2), which was responsible for p,p"-DDT-induced enhancement of aerobic glycolysis.	Pyruvates	85-93	pyruvate kinase M1/2	Homo sapiens	102-106
32064930-5	2020	LDHA converts pyruvate to lactate in the final step of glycolysis and is often upregulated in cancer.	Pyruvates	14-22	lactate dehydrogenase A	Homo sapiens	0-4
31901148-2	2020	The M2 isoform of pyruvate kinase (PKM2) has a key role in catalyzing glycolysis, and PKM2 expression varies even within a single tumor.	Pyruvates	18-26	pyruvate kinase M1/2	Homo sapiens	35-39
31901148-2	2020	The M2 isoform of pyruvate kinase (PKM2) has a key role in catalyzing glycolysis, and PKM2 expression varies even within a single tumor.	Pyruvates	18-26	pyruvate kinase M1/2	Homo sapiens	86-90
31931141-15	2020	Pyruvate carboxylase (PC) and pyruvate dehydrogenase (PDH) are the two main enzymes controlling pyruvate entry to the TCA cycle.	Pyruvates	30-38	pyruvate carboxylase	Homo sapiens	22-24
31931141-15	2020	Pyruvate carboxylase (PC) and pyruvate dehydrogenase (PDH) are the two main enzymes controlling pyruvate entry to the TCA cycle.	Pyruvates	30-38	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	54-57
31874860-5	2020	Conversion from pyruvate to acetate is activated under hypoxic conditions, and ACS recovers carbon that would otherwise be lost from the plant as ethanol.	Pyruvates	16-24	acetyl-CoA synthetase	Arabidopsis thaliana	79-82
32058954-3	2020	At the cellular level, BMAL1 suppresses the flexibility of mitochondrial substrate usage and the pyruvate-dependent mitochondrial respiration induced by CIT.	Pyruvates	97-105	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	23-28
31838085-5	2020	AR signaling upregulates DRP1 to form the VDAC-MPC2 complex, increases pyruvate transport into mitochondria, and supports mitochondrial metabolism, including oxidative phosphorylation and lipogenesis.	Pyruvates	71-79	androgen receptor	Homo sapiens	0-2
31845497-4	2020	By coupling FDH* and NCD-dependent malic enzyme (ME*), we demonstrated the successful utilization of formate as both CO 2 source and electron donor for reductive carboxylation of pyruvate with a perfect stoichiometry between formate and malate.	Pyruvates	179-187	aldehyde dehydrogenase 1 family member L1	Homo sapiens	12-15
32075767-5	2020	Importantly, this latter event is linked to glycogen-synthase-kinase-3beta (GSK-3beta) hyper-activation, leading, in turn, to impaired recruitment of hexokinase 1 (HK1) to mitochondria, destabilization of mitochondrial-pyruvate-carrier (MPC) complexes, and decreased MPC2 protein levels.	Pyruvates	219-227	glycogen synthase kinase 3 beta	Homo sapiens	44-74
32075767-5	2020	Importantly, this latter event is linked to glycogen-synthase-kinase-3beta (GSK-3beta) hyper-activation, leading, in turn, to impaired recruitment of hexokinase 1 (HK1) to mitochondria, destabilization of mitochondrial-pyruvate-carrier (MPC) complexes, and decreased MPC2 protein levels.	Pyruvates	219-227	glycogen synthase kinase 3 alpha	Homo sapiens	76-85
32058969-4	2020	Prolonged exposure to excess glucose led to hyperactivation of mTORC1 and metabolic acceleration, characterized by higher basal respiration and maximal respiratory capacity, increased energy demand, and enhanced flux through mitochondrial pyruvate metabolism.	Pyruvates	239-247	CREB regulated transcription coactivator 1	Mus musculus	63-69
32058969-5	2020	Inhibition of pyruvate transport to the mitochondria decelerated the metabolism of beta-cells chronically exposed to excess glucose and re-established glucose-dependent mTORC1 signaling, disrupting a positive feedback loop for mTORC1 hyperactivation.	Pyruvates	14-22	CREB regulated transcription coactivator 1	Mus musculus	169-175
32058969-5	2020	Inhibition of pyruvate transport to the mitochondria decelerated the metabolism of beta-cells chronically exposed to excess glucose and re-established glucose-dependent mTORC1 signaling, disrupting a positive feedback loop for mTORC1 hyperactivation.	Pyruvates	14-22	CREB regulated transcription coactivator 1	Mus musculus	227-233
31924651-4	2020	Although the tetramer form of PKM2 converts phosphoenolpyruvate to pyruvate, the dimeric form of PKM2 has alternative, nonglycolysis functions as a transcriptional coactivator to enhance the transcription of several proinflammatory cytokines.	Pyruvates	55-63	pyruvate kinase, muscle	Mus musculus	30-34
32075767-5	2020	Importantly, this latter event is linked to glycogen-synthase-kinase-3beta (GSK-3beta) hyper-activation, leading, in turn, to impaired recruitment of hexokinase 1 (HK1) to mitochondria, destabilization of mitochondrial-pyruvate-carrier (MPC) complexes, and decreased MPC2 protein levels.	Pyruvates	219-227	hexokinase 1	Homo sapiens	150-162
32075767-5	2020	Importantly, this latter event is linked to glycogen-synthase-kinase-3beta (GSK-3beta) hyper-activation, leading, in turn, to impaired recruitment of hexokinase 1 (HK1) to mitochondria, destabilization of mitochondrial-pyruvate-carrier (MPC) complexes, and decreased MPC2 protein levels.	Pyruvates	219-227	hexokinase 1	Homo sapiens	164-167
31821485-3	2020	The current study investigates the importance of the two isoenzymes of pyruvate carboxylase (PYC1 and PYC2) and one of the key enzymes of the glyoxylate cycle (ICL1) for growth on glycerol (C3) as a sole carbon source.	Pyruvates	71-79	pyruvate carboxylase 1	Saccharomyces cerevisiae S288C	93-97
32029721-6	2020	The metabolic switch triggering this global histone hypoacetylation was the induction of pyruvate dehydrogenase kinases (PDK1 and PDK3).	Pyruvates	89-97	pyruvate dehydrogenase kinase 1	Homo sapiens	121-125
32029721-6	2020	The metabolic switch triggering this global histone hypoacetylation was the induction of pyruvate dehydrogenase kinases (PDK1 and PDK3).	Pyruvates	89-97	pyruvate dehydrogenase kinase 3	Homo sapiens	130-134
32033380-8	2020	Our results show the feasibility of monitoring the beta-elimination of KYAT1 by our assay and the results were compared to the previously described beta-elimination assays measuring pyruvate.	Pyruvates	182-190	kynurenine aminotransferase 1	Homo sapiens	71-76
32019928-4	2020	Moreover, we find that inflammatory macrophages reroute pyruvate away from pyruvate dehydrogenase (PDH) in an NO-dependent and hypoxia-inducible factor 1alpha (Hif1alpha)-independent manner, thereby promoting glutamine-based anaplerosis.	Pyruvates	56-64	hypoxia inducible factor 1, alpha subunit	Mus musculus	127-158
32019928-4	2020	Moreover, we find that inflammatory macrophages reroute pyruvate away from pyruvate dehydrogenase (PDH) in an NO-dependent and hypoxia-inducible factor 1alpha (Hif1alpha)-independent manner, thereby promoting glutamine-based anaplerosis.	Pyruvates	56-64	hypoxia inducible factor 1, alpha subunit	Mus musculus	160-169
32019928-4	2020	Moreover, we find that inflammatory macrophages reroute pyruvate away from pyruvate dehydrogenase (PDH) in an NO-dependent and hypoxia-inducible factor 1alpha (Hif1alpha)-independent manner, thereby promoting glutamine-based anaplerosis.	Pyruvates	75-83	hypoxia inducible factor 1, alpha subunit	Mus musculus	160-169
31918262-6	2020	Furthermore, exosomal Kras inhibition downregulated transcription factor BACH2/GATA-3 expression in lung tumor tissues by shifting pyruvate/PKM2 dependent metabolism, contributing to a tumor-restraining status.	Pyruvates	131-139	KRAS proto-oncogene, GTPase	Homo sapiens	22-26
31918262-6	2020	Furthermore, exosomal Kras inhibition downregulated transcription factor BACH2/GATA-3 expression in lung tumor tissues by shifting pyruvate/PKM2 dependent metabolism, contributing to a tumor-restraining status.	Pyruvates	131-139	BTB domain and CNC homolog 2	Homo sapiens	73-78
31918262-6	2020	Furthermore, exosomal Kras inhibition downregulated transcription factor BACH2/GATA-3 expression in lung tumor tissues by shifting pyruvate/PKM2 dependent metabolism, contributing to a tumor-restraining status.	Pyruvates	131-139	GATA binding protein 3	Homo sapiens	79-85
31678165-6	2020	Recent studies have shown that Pin1 also binds to a variety of metabolic regulators, such as AMP-activated protein kinase, acetyl CoA carboxylase and pyruvate kinase2, indicating Pin1 to have major impacts on lipid and glucose metabolism in cancer cells.	Pyruvates	150-158	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	31-35
31678165-6	2020	Recent studies have shown that Pin1 also binds to a variety of metabolic regulators, such as AMP-activated protein kinase, acetyl CoA carboxylase and pyruvate kinase2, indicating Pin1 to have major impacts on lipid and glucose metabolism in cancer cells.	Pyruvates	150-158	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	179-183
32071289-3	2020	Here, we demonstrated high expression of the mitochondrial gatekeeping enzyme, pyruvate dehydrogenase kinase 1 (PDK1), in both clinical samples and cell lines of ovarian cancer.	Pyruvates	79-87	pyruvate dehydrogenase kinase 1	Homo sapiens	112-116
32041182-5	2020	Decreased PDH activity and upregulation of PC shuttled more pyruvate to oxaloacetate.	Pyruvates	60-68	pyruvate carboxylase	Rattus norvegicus	43-45
32041182-8	2020	PC inhibition reduced the glycolytic shift by attenuating Akt-signaling, glycolysis, and restored mitochondrial pyruvate oxidation.	Pyruvates	112-120	pyruvate carboxylase	Rattus norvegicus	0-2
31593685-2	2020	Among hMCTs, hMCT1-4 cotransport H+ with monocarboxylates such as pyruvate and l-lactate, implying that these proteins recognize both substrate and H+.	Pyruvates	66-74	solute carrier family 16 member 14	Homo sapiens	13-20
31928475-6	2020	A new insulin sensitizer that targets the newly identified mitochondrial pyruvate carrier could provide an approach.Expert Opinion: A metabolic approach is needed for the treatment of NASH.	Pyruvates	73-81	insulin	Homo sapiens	6-13
31928475-7	2020	Clinical studies are underway to determine whether a new insulin sensitizer that targets pyruvate metabolism can impact NASH, T2D, and cardiovascular disease.	Pyruvates	89-97	insulin	Homo sapiens	57-64
31821485-3	2020	The current study investigates the importance of the two isoenzymes of pyruvate carboxylase (PYC1 and PYC2) and one of the key enzymes of the glyoxylate cycle (ICL1) for growth on glycerol (C3) as a sole carbon source.	Pyruvates	71-79	pyruvate carboxylase 2	Saccharomyces cerevisiae S288C	102-106
31781893-10	2020	In conclusion, the present findings suggest that skeletal muscle IL-6 regulates markers of lipolysis in VAT in the basal state and pyruvate availability for glyceroneogenesis in VAT with exercise.	Pyruvates	131-139	interleukin 6	Mus musculus	65-69
31760602-0	2020	Purification and Characterization of Prolyl Hydroxylase 3/Pyruvate Kinase Isoform 2 Protein Complex.	Pyruvates	58-66	egl-9 family hypoxia inducible factor 3	Homo sapiens	37-57
31991719-11	2020	Prevention of Akt-nitration significantly controlled pyruvate in oxidative phosphorylation by decreasing lactate and increasing pyruvate dehydrogenases activities.	Pyruvates	53-61	AKT serine/threonine kinase 1	Homo sapiens	14-17
31964840-4	2020	Expression of lactate dehydrogenase A (LDHA), which catalyzes 13C label exchange between pyruvate and lactate, hypoxia-inducible factor-1 (HIF1alpha), and the monocarboxylate transporters MCT1 and MCT4 were quantified using immunohistochemistry and RNA sequencing.	Pyruvates	89-97	lactate dehydrogenase A	Homo sapiens	14-37
31964840-4	2020	Expression of lactate dehydrogenase A (LDHA), which catalyzes 13C label exchange between pyruvate and lactate, hypoxia-inducible factor-1 (HIF1alpha), and the monocarboxylate transporters MCT1 and MCT4 were quantified using immunohistochemistry and RNA sequencing.	Pyruvates	89-97	lactate dehydrogenase A	Homo sapiens	39-43
31735334-8	2020	Conversely, compared to HCA, the HCC lesion display increased expression of many oncogenes and the M2 isoform of pyruvate kinase (PKM2), a glycolytic enzyme critical for aerobic glycolysis and tumorigenesis.	Pyruvates	113-121	pyruvate kinase M1/2	Homo sapiens	130-134
31991719-11	2020	Prevention of Akt-nitration significantly controlled pyruvate in oxidative phosphorylation by decreasing lactate and increasing pyruvate dehydrogenases activities.	Pyruvates	128-136	AKT serine/threonine kinase 1	Homo sapiens	14-17
31885322-7	2020	This review focuses on these aspects of cyclin D1 pathophysiology, which may be crucial for targeted therapy.Abbreviations: aa, amino acid; AR, androgen receptor; ATM, ataxia telangectasia mutant; ATR, ATM and Rad3-related; CDK, cyclin-dependent kinase; ChREBP, carbohydrate response element binding protein; CIP, CDK-interacting protein; CHK1/2, checkpoint kinase 1/2; CKI, CDK inhibitor; DDR, DNA damage response; DMP1, cyclin D-binding myb-like protein; DSB, double-strand DNA break; DNA-PK, DNA-dependent protein kinase; ER, estrogen receptor; FASN, fatty acid synthase; GSK3beta, glycogen synthase-3beta; HAT, histone acetyltransferase; HDAC, histone deacetylase; HK2, hexokinase 2; HNF4alpha, and hepatocyte nuclear factor 4alpha; HR, homologous recombination; IR, ionizing radiation; KIP, kinase inhibitory protein; MCL, mantle cell lymphoma; NHEJ, non-homologous end-joining; PCAF, p300/CREB binding-associated protein; PGC1alpha, PPARgamma co-activator 1alpha; PEST, proline-glutamic acid-serine-threonine, PK, pyruvate kinase; PPAR, peroxisome proliferator-activated receptor; RB1, retinoblastoma protein; ROS, reactive oxygen species; SRC, steroid receptor coactivator; STAT, signal transducer and activator of transcription; TGFbeta, transforming growth factor beta; UPS, ubiquitin-proteasome system; USP22, ubiquitin-specific peptidase 22; XPO1 (or CRM1) exportin 1.	Pyruvates	1020-1028	cyclin D1	Mus musculus	40-49
31907035-1	2020	BACKGROUND: The mitochondrial pyruvate carrier (MPC) plays a central role in energy metabolism by transporting pyruvate across the inner mitochondrial membrane.	Pyruvates	30-38	mitochondrial pyruvate carrier	Saccharomyces cerevisiae S288C	48-51
31564440-5	2020	RNA sequencing data demonstrate a significant increase in the predominant pyruvate uptake transporter, monocarboxylate transporter 1.	Pyruvates	74-82	solute carrier family 16 member 1	Homo sapiens	103-132
31682172-8	2020	Increased AGT expression induced by treatment with pyruvate, a glucose metabolite that does not require SGLT2 for uptake, was not attenuated by CANA.	Pyruvates	51-59	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	10-13
31891638-11	2019	Protein levels of pyruvate:NADP+ oxidoreductase, a key enzyme for anaerobic synthesis of acetyl-CoA, which serves as a C2 donor for fatty acids, showed a 1.68-fold increase under hypoxic conditions, whereas those of pyruvate dehydrogenase subunits showed a 0.77-0.81-fold decrease.	Pyruvates	18-26	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	33-47
31639438-6	2020	Indeed, 6NJ and 6J mitochondria energized with pyruvate or succinate displayed similar rates for H2O2 elimination, quenching ~84% and ~86% of the H2O2, respectively, in the surrounding medium within 30 s. However, inclusion of palmitoyl-CoA, an NNT inhibitor, significantly limited H2O2 degradation by 6NJ mitochondria only (~55% of H2O2 eliminated in 30 s).	Pyruvates	47-55	nicotinamide nucleotide transhydrogenase	Mus musculus	245-248
31697642-9	2020	Forced miR-375 expression in rat or human islets increased mRNA levels of pyruvate dehydrogenase kinase-4, but decreased those of pyruvate carboxylase and malate dehydrogenase1.	Pyruvates	74-82	microRNA 375	Rattus norvegicus	7-14
31641207-0	2020	A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism.	Pyruvates	107-115	lysine demethylase 5A	Homo sapiens	8-13
31641207-0	2020	A novel KDM5A/MPC-1 signaling pathway promotes pancreatic cancer progression via redirecting mitochondrial pyruvate metabolism.	Pyruvates	107-115	mitochondrial pyruvate carrier 1	Homo sapiens	14-19
31641207-4	2020	Both in vitro and in vivo models were used to determine biologic impacts of MPC-1 and KDM5A on PDA and mitochondrial pyruvate metabolism, and the mechanism underling reduced MPC-1 expression in PDA.	Pyruvates	117-125	mitochondrial pyruvate carrier 1	Homo sapiens	76-81
31641207-4	2020	Both in vitro and in vivo models were used to determine biologic impacts of MPC-1 and KDM5A on PDA and mitochondrial pyruvate metabolism, and the mechanism underling reduced MPC-1 expression in PDA.	Pyruvates	117-125	lysine demethylase 5A	Homo sapiens	86-91
31641207-7	2020	Re-expression of MPC-1 stimulated the mitochondrial pyruvate metabolism and inhibited glycolysis, while MPC-1-specific inhibitor UK5099 attenuated these effects.	Pyruvates	52-60	mitochondrial pyruvate carrier 1	Homo sapiens	17-22
31641207-11	2020	KDM5A/MPC-1 signaling promoted PDA growth, invasion, migration, and stemness via inhibiting mitochondrial pyruvate metabolism.	Pyruvates	106-114	lysine demethylase 5A	Homo sapiens	0-5
31641207-11	2020	KDM5A/MPC-1 signaling promoted PDA growth, invasion, migration, and stemness via inhibiting mitochondrial pyruvate metabolism.	Pyruvates	106-114	mitochondrial pyruvate carrier 1	Homo sapiens	6-11
32003689-11	2020	Butyrate, orexin and melatonin can positively regulate mitochondria via the disinhibition of the pyruvate dehydrogenase complex, leading to increased conversion of pyruvate to acetyl-CoA.	Pyruvates	97-105	hypocretin neuropeptide precursor	Homo sapiens	10-16
32003689-11	2020	Butyrate, orexin and melatonin can positively regulate mitochondria via the disinhibition of the pyruvate dehydrogenase complex, leading to increased conversion of pyruvate to acetyl-CoA.	Pyruvates	164-172	hypocretin neuropeptide precursor	Homo sapiens	10-16
31833658-8	2020	BRAF inhibition induced a significant increase in the HP pyruvate-to-lactate conversion in vivo, followed by a reduction of hypoxia.	Pyruvates	57-65	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
31654802-10	2020	Our data connects a constitutive expression of HIF-1alpha in response to FA, to the inhibition of pyruvate decarboxylation through up-regulation of PDK-1 and phosphorylation of Pyruvate Dehydrogenase E1alpha subunit.	Pyruvates	98-106	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57
31654802-10	2020	Our data connects a constitutive expression of HIF-1alpha in response to FA, to the inhibition of pyruvate decarboxylation through up-regulation of PDK-1 and phosphorylation of Pyruvate Dehydrogenase E1alpha subunit.	Pyruvates	98-106	pyruvate dehydrogenase kinase 1	Homo sapiens	148-153
31654802-10	2020	Our data connects a constitutive expression of HIF-1alpha in response to FA, to the inhibition of pyruvate decarboxylation through up-regulation of PDK-1 and phosphorylation of Pyruvate Dehydrogenase E1alpha subunit.	Pyruvates	177-185	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57
31891638-11	2019	Protein levels of pyruvate:NADP+ oxidoreductase, a key enzyme for anaerobic synthesis of acetyl-CoA, which serves as a C2 donor for fatty acids, showed a 1.68-fold increase under hypoxic conditions, whereas those of pyruvate dehydrogenase subunits showed a 0.77-0.81-fold decrease.	Pyruvates	216-224	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	33-47
31921691-3	2019	Lactate dehydrogenase A (LDHA) promotes glycolysis process by catalyzing the conversion of pyruvate to lactate.	Pyruvates	91-99	lactate dehydrogenase A	Homo sapiens	0-23
31921691-3	2019	Lactate dehydrogenase A (LDHA) promotes glycolysis process by catalyzing the conversion of pyruvate to lactate.	Pyruvates	91-99	lactate dehydrogenase A	Homo sapiens	25-29
31804482-2	2019	Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH that catalyzes the interconversion between pyruvate and lactate.	Pyruvates	187-195	aurora kinase A	Homo sapiens	21-29
31712311-2	2019	Here we show that in the highly lethal brain tumor glioblastoma (GBM), mechanistic target of rapamycin complex 2 (mTORC2), a critical core component of the growth factor signaling system, couples acetyl-CoA production with nuclear translocation of histone-modifying enzymes including pyruvate dehydrogenase (PDH) and class IIa histone deacetylases (HDACs) to globally alter histone acetylation.	Pyruvates	284-292	CREB regulated transcription coactivator 2	Mus musculus	114-120
31851938-4	2019	Sirt6+/- results in significantly reduced PPARalpha-induced beta-oxidation and its metabolites and reduced alanine and lactate levels, while inducing pyruvate oxidation.	Pyruvates	150-158	sirtuin 6	Mus musculus	0-5
31851938-4	2019	Sirt6+/- results in significantly reduced PPARalpha-induced beta-oxidation and its metabolites and reduced alanine and lactate levels, while inducing pyruvate oxidation.	Pyruvates	150-158	peroxisome proliferator activated receptor alpha	Mus musculus	42-51
31851938-5	2019	Reciprocally, starved SIRT6 transgenic mice show increased pyruvate, acetylcarnitine, and glycerol levels and significantly induce beta-oxidation genes in a PPARalpha-dependent manner.	Pyruvates	59-67	sirtuin 6	Mus musculus	22-27
31825824-2	2019	We recently observed a pyruvate kinase liver isoform (PKL) phosphorylation site at S113 that correlates with insulin resistance in rats on a 3 day high-fat diet (HFD) and suggests additional control points for PKL activity.	Pyruvates	23-31	pyruvate kinase L/R	Rattus norvegicus	54-57
31825824-2	2019	We recently observed a pyruvate kinase liver isoform (PKL) phosphorylation site at S113 that correlates with insulin resistance in rats on a 3 day high-fat diet (HFD) and suggests additional control points for PKL activity.	Pyruvates	23-31	pyruvate kinase L/R	Rattus norvegicus	210-213
31804482-2	2019	Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH that catalyzes the interconversion between pyruvate and lactate.	Pyruvates	187-195	lactate dehydrogenase B	Homo sapiens	73-96
31804482-2	2019	Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH that catalyzes the interconversion between pyruvate and lactate.	Pyruvates	187-195	lactate dehydrogenase B	Homo sapiens	98-102
31804482-2	2019	Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subunit of the tetrameric enzyme LDH that catalyzes the interconversion between pyruvate and lactate.	Pyruvates	187-195	lactate dehydrogenase B	Homo sapiens	98-101
31804482-3	2019	Aurora-A-mediated phosphorylation of LDHB serine 162 significantly increases its activity in reducing pyruvate to lactate, which efficiently promotes NAD+ regeneration, glycolytic flux, lactate production and bio-synthesis with glycolytic intermediates.	Pyruvates	102-110	aurora kinase A	Homo sapiens	0-8
31804482-3	2019	Aurora-A-mediated phosphorylation of LDHB serine 162 significantly increases its activity in reducing pyruvate to lactate, which efficiently promotes NAD+ regeneration, glycolytic flux, lactate production and bio-synthesis with glycolytic intermediates.	Pyruvates	102-110	lactate dehydrogenase B	Homo sapiens	37-41
31804482-4	2019	Mechanistically, LDHB serine 162 phosphorylation relieves its substrate inhibition effect by pyruvate, resulting in remarkable elevation in the conversions of pyruvate and NADH to lactate and NAD+.	Pyruvates	93-101	lactate dehydrogenase B	Homo sapiens	17-21
31804482-4	2019	Mechanistically, LDHB serine 162 phosphorylation relieves its substrate inhibition effect by pyruvate, resulting in remarkable elevation in the conversions of pyruvate and NADH to lactate and NAD+.	Pyruvates	159-167	lactate dehydrogenase B	Homo sapiens	17-21
31598701-0	2019	Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT-NAD+-SIRT1 pathway.	Pyruvates	10-18	nicotinamide phosphoribosyltransferase	Homo sapiens	100-105
31804603-5	2019	C-Myc downregulation decreased the expression of lactate dehydrogenase A, the enzyme catalyzing the conversion of pyruvate to lactate.	Pyruvates	114-122	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
31804603-5	2019	C-Myc downregulation decreased the expression of lactate dehydrogenase A, the enzyme catalyzing the conversion of pyruvate to lactate.	Pyruvates	114-122	lactate dehydrogenase A	Homo sapiens	49-72
31598701-6	2019	Chromatin immunoprecipitation analysis indicates that pyruvate enhances SIRT1 binding at histone gene promoters where it reduces histone acetylation.	Pyruvates	54-62	sirtuin 1	Homo sapiens	72-77
31598701-0	2019	Exogenous pyruvate represses histone gene expression and inhibits cancer cell proliferation via the NAMPT-NAD+-SIRT1 pathway.	Pyruvates	10-18	sirtuin 1	Homo sapiens	111-116
31598701-5	2019	Pyruvate represses histone gene expression by inducing the expression of NAD+ biosynthesis enzyme, nicotinamide phosphoribosyltransferase (NAMPT) via myocyte enhancer factor 2C (MEF2C), which then increases NAD+ levels and activates the histone deacetylase activity of SIRT1.	Pyruvates	0-8	nicotinamide phosphoribosyltransferase	Homo sapiens	99-137
31598701-5	2019	Pyruvate represses histone gene expression by inducing the expression of NAD+ biosynthesis enzyme, nicotinamide phosphoribosyltransferase (NAMPT) via myocyte enhancer factor 2C (MEF2C), which then increases NAD+ levels and activates the histone deacetylase activity of SIRT1.	Pyruvates	0-8	nicotinamide phosphoribosyltransferase	Homo sapiens	139-144
31598701-5	2019	Pyruvate represses histone gene expression by inducing the expression of NAD+ biosynthesis enzyme, nicotinamide phosphoribosyltransferase (NAMPT) via myocyte enhancer factor 2C (MEF2C), which then increases NAD+ levels and activates the histone deacetylase activity of SIRT1.	Pyruvates	0-8	myocyte enhancer factor 2C	Homo sapiens	150-176
31598701-5	2019	Pyruvate represses histone gene expression by inducing the expression of NAD+ biosynthesis enzyme, nicotinamide phosphoribosyltransferase (NAMPT) via myocyte enhancer factor 2C (MEF2C), which then increases NAD+ levels and activates the histone deacetylase activity of SIRT1.	Pyruvates	0-8	myocyte enhancer factor 2C	Homo sapiens	178-183
31598701-5	2019	Pyruvate represses histone gene expression by inducing the expression of NAD+ biosynthesis enzyme, nicotinamide phosphoribosyltransferase (NAMPT) via myocyte enhancer factor 2C (MEF2C), which then increases NAD+ levels and activates the histone deacetylase activity of SIRT1.	Pyruvates	0-8	sirtuin 1	Homo sapiens	269-274
31582221-2	2019	Pyruvate dehydrogenase (PDH) is a metabolic enzyme that converts pyruvate into acetyl-CoA, connecting glycolysis to the TCA cycle, thus regulating cellular energy metabolism.	Pyruvates	65-73	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	0-22
32010559-7	2019	For different TNM stages, the pyruvate content (P<0.001) and lactate content (P<0.001) in the II/III/IV stage cancer tissues were significantly higher than those in the stage I cancer tissues.	Pyruvates	30-38	teneurin transmembrane protein 1	Homo sapiens	14-17
31582221-2	2019	Pyruvate dehydrogenase (PDH) is a metabolic enzyme that converts pyruvate into acetyl-CoA, connecting glycolysis to the TCA cycle, thus regulating cellular energy metabolism.	Pyruvates	65-73	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	24-27
31819487-2	2019	Pyruvate dehydrogenase E1 alpha subunit (PDHA1) is an important prerequisite for OXPHOS.	Pyruvates	0-8	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	41-46
31824549-8	2019	The deficiency of thiamine in Gmpgl1 mutant led to reduced activities of the pyruvate dehydrogenase (PDH) and pyruvate decarboxylase (PDC), and decreased contents of six amino acids as compared to that in the wild type plants.	Pyruvates	77-85	proline dehydrogenase	Glycine max	101-104
31606382-5	2019	Mitochondrial pyruvate carrier 2 (MPC2) mediates pyruvate transport from the cytoplasm to the mitochondrial matrix, which determines the cellular energy supply and cell survival.	Pyruvates	14-22	mitochondrial pyruvate carrier 2	Homo sapiens	34-38
31747582-4	2019	In contrast to in vitro-activated T cells, which display hallmarks of Warburg metabolism, physiologically activated CD8+ T cells displayed greater rates of oxidative metabolism, higher bioenergetic capacity, differential use of pyruvate, and prominent flow of 13C-glucose carbon to anabolic pathways, including nucleotide and serine biosynthesis.	Pyruvates	228-236	CD8a molecule	Homo sapiens	116-119
31602208-11	2019	Puerarin upregulated peroxisome proliferator-activated receptor alpha (PPARalpha) and its downstream target genes nuclear respiratory factor 1, FOS proto-oncogene, YY1 transcription factor, acetyl-coenzyme A carboxylase a, Fas cell surface death receptor, L-type pyruvate kinase and acetyl-coenzyme A dehydrogenase medium chain in myocardial cells from rats with chronic heart failure.	Pyruvates	263-271	peroxisome proliferator activated receptor alpha	Rattus norvegicus	71-80
31576870-3	2019	We probe the reactivity of this species by NMR and DFT and upon reaction with sodium pyruvate establish the formation of two isomers of [Ir(H)2(eta2-pyruvate)(DMSO)(IMes)].	Pyruvates	78-93	DNA polymerase iota	Homo sapiens	144-148
31648290-6	2019	In this paper, we demonstrate the efficient recruitment of pyruvate decarboxylase (Pdc1) and alcohol dehydrogenase (Adh1) fermentation enzymes into the viral replication compartment.	Pyruvates	59-67	indolepyruvate decarboxylase 1	Saccharomyces cerevisiae S288C	83-87
31648290-6	2019	In this paper, we demonstrate the efficient recruitment of pyruvate decarboxylase (Pdc1) and alcohol dehydrogenase (Adh1) fermentation enzymes into the viral replication compartment.	Pyruvates	59-67	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	116-120
31636306-5	2019	In this study, we demonstrate that the glycolytic enzyme pyruvate kinase 2 (PKM2) is required for sprouting angiogenesis in vitro and in vivo through the regulation of endothelial cell-junction dynamics and collective migration.	Pyruvates	57-65	pyruvate kinase M1/2	Homo sapiens	76-80
31618280-1	2019	Pyruvate Kinase Deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene, which encodes the erythroid specific Pyruvate Kinase enzyme.	Pyruvates	0-8	protein kinase D1	Homo sapiens	28-31
31618280-1	2019	Pyruvate Kinase Deficiency (PKD) is a rare erythroid metabolic disease caused by mutations in the PKLR gene, which encodes the erythroid specific Pyruvate Kinase enzyme.	Pyruvates	0-8	pyruvate kinase L/R	Homo sapiens	98-102
31893043-2	2019	Pyruvate kinase, especially the M2 isoform (PKM2), is highly expressed in PDAC cells, but its role in pancreatic cancer remains controversial.	Pyruvates	0-8	pyruvate kinase, muscle	Mus musculus	44-48
31893043-8	2019	The serine biosynthesis pathway partially contributed to pyruvate production during PKM1/2 knockdown: knockout of phosphoglycerate dehydrogenase in this pathway decreased pyruvate production from glucose.	Pyruvates	57-65	pyruvate kinase, muscle	Mus musculus	84-90
31893043-8	2019	The serine biosynthesis pathway partially contributed to pyruvate production during PKM1/2 knockdown: knockout of phosphoglycerate dehydrogenase in this pathway decreased pyruvate production from glucose.	Pyruvates	171-179	pyruvate kinase, muscle	Mus musculus	84-90
31893043-15	2019	Investigating several alternative sources of pyruvate identified cysteine catabolism for pyruvate production during PKM1/2 knockdown.	Pyruvates	45-53	pyruvate kinase, muscle	Mus musculus	116-122
31893043-15	2019	Investigating several alternative sources of pyruvate identified cysteine catabolism for pyruvate production during PKM1/2 knockdown.	Pyruvates	89-97	pyruvate kinase, muscle	Mus musculus	116-122
31615527-3	2019	In this study, mitochondrial pyruvate transporter gene (MPC1) or the essential gene for mitophagy (ATG32) was knocked-out to repress the mitochondrial metabolism and improve the production of pyruvate-derived chemical in S. cerevisiae.	Pyruvates	29-37	pyruvate transporter MPC1	Saccharomyces cerevisiae S288C	56-60
31615527-3	2019	In this study, mitochondrial pyruvate transporter gene (MPC1) or the essential gene for mitophagy (ATG32) was knocked-out to repress the mitochondrial metabolism and improve the production of pyruvate-derived chemical in S. cerevisiae.	Pyruvates	192-200	pyruvate transporter MPC1	Saccharomyces cerevisiae S288C	56-60
31615527-3	2019	In this study, mitochondrial pyruvate transporter gene (MPC1) or the essential gene for mitophagy (ATG32) was knocked-out to repress the mitochondrial metabolism and improve the production of pyruvate-derived chemical in S. cerevisiae.	Pyruvates	192-200	mitophagy protein ATG32	Saccharomyces cerevisiae S288C	99-104
31549019-2	2019	One of the putative alanine aminotransferases genes, At3g08860, was attributed the function of alanine:glyoxylate aminotransferase/beta-alanine:pyruvate aminotransferase based on the analysis of gene expression networks and homology to other beta-alanine aminotransferases in plants.	Pyruvates	144-152	alanine:glyoxylate aminotransferase	Arabidopsis thaliana	95-130
31594538-4	2019	RESULTS: Here, we present data suggesting that LSH regulates p53 in cis through two pathways: prevention proteasomal degradation through its deubiquitination, which is achieved by reducing the lysine 11-linked, lysine 48-linked polyubiquitin chains (K11 and K48) on p53; and revival of the transcriptional activity of p53 by forming a complex with PKM2 (pyruvate kinase 2).	Pyruvates	354-362	helicase, lymphoid specific	Homo sapiens	47-50
31594538-4	2019	RESULTS: Here, we present data suggesting that LSH regulates p53 in cis through two pathways: prevention proteasomal degradation through its deubiquitination, which is achieved by reducing the lysine 11-linked, lysine 48-linked polyubiquitin chains (K11 and K48) on p53; and revival of the transcriptional activity of p53 by forming a complex with PKM2 (pyruvate kinase 2).	Pyruvates	354-362	tumor protein p53	Homo sapiens	61-64
31632919-0	2019	Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis.	Pyruvates	100-108	pyruvate kinase M1/2	Homo sapiens	119-123
31632919-3	2019	Pyruvate kinase 2 (PKM2), the last rate-limiting enzyme of glycolysis, is known to regulate aerobic glycolysis, and considered as a novel cancer therapeutic target.	Pyruvates	0-8	pyruvate kinase M1/2	Homo sapiens	19-23
31632919-6	2019	MCL, the active metabolic form of DMAMCL, selectively binding to monomeric PKM2 and promoting its tetramerization, was also found to improve the pyruvate kinase activity of PKM2 in GBM cells.	Pyruvates	145-153	pyruvate kinase M1/2	Homo sapiens	173-177
31565219-7	2019	Increased phosphofructokinase expression was observed in ERalpha-/- and ERalphabeta-/- mice, whereas increased pyruvate kinase isozyme M2 and pyruvate dehydrogenase expression was observed in ERbeta-/- and ERalphabeta-/- mice.	Pyruvates	111-119	estrogen receptor 2 (beta)	Mus musculus	192-198
31565219-7	2019	Increased phosphofructokinase expression was observed in ERalpha-/- and ERalphabeta-/- mice, whereas increased pyruvate kinase isozyme M2 and pyruvate dehydrogenase expression was observed in ERbeta-/- and ERalphabeta-/- mice.	Pyruvates	142-150	estrogen receptor 2 (beta)	Mus musculus	192-198
31550253-10	2019	In addition, pyruvate dehydrogenase activity was reduced, accompanied by 10-15-fold increased gene expression of its regulator pyruvate dehydrogenase kinase 4 compared to control, suggesting reduced entry of pyruvate into the TCA cycle.	Pyruvates	13-21	pyruvate dehydrogenase kinase 4	Rattus norvegicus	127-158
31550253-11	2019	Indeed, the NADPH-generating enzyme malic enzyme 1 (ME1) catalysing production of pyruvate from malate, was increased 13-fold at the gene expression level.	Pyruvates	82-90	malic enzyme 1	Rattus norvegicus	36-50
31550253-11	2019	Indeed, the NADPH-generating enzyme malic enzyme 1 (ME1) catalysing production of pyruvate from malate, was increased 13-fold at the gene expression level.	Pyruvates	82-90	malic enzyme 1	Rattus norvegicus	52-55
31880514-2	2019	The conversion of phosphoenolpyruvate (PEP) to pyruvate can be down regulated by the re-expression of the embryonic isoform 2 of pyruvate kinase (PKM2).	Pyruvates	29-37	pyruvate kinase M1/2	Homo sapiens	146-150
31880514-2	2019	The conversion of phosphoenolpyruvate (PEP) to pyruvate can be down regulated by the re-expression of the embryonic isoform 2 of pyruvate kinase (PKM2).	Pyruvates	47-55	pyruvate kinase M1/2	Homo sapiens	146-150