PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 3680222-1 1987 Orotate phosphoribosyltransferase (EC 2.4.2.10) and orotidine 5"-monophosphate decarboxylase (EC 4.1.1.23) are the final two of six enzymatic steps required in the de novo biosynthesis of uridine 5"-monophosphate (UMP). Uridine Monophosphate 188-212 uridine monophosphate synthetase Homo sapiens 0-33 3680222-1 1987 Orotate phosphoribosyltransferase (EC 2.4.2.10) and orotidine 5"-monophosphate decarboxylase (EC 4.1.1.23) are the final two of six enzymatic steps required in the de novo biosynthesis of uridine 5"-monophosphate (UMP). Uridine Monophosphate 214-217 uridine monophosphate synthetase Homo sapiens 0-33 2822457-5 1987 dNase activity occurred with both purine and pyrimidine substrates and was maximal with deoxy analogs (dIMP much greater than dUMP greater than dGMP greater than dTMP = dAMP much greater than dCMP) at a pH optimum of 6.2, but slight cross-reactivity occurred with some nondeoxy substrates (IMP greater than GMP greater than UMP = XMP greater than CMP). Uridine Monophosphate 127-130 Deoxyribonuclease II Drosophila melanogaster 0-5 3651388-2 1987 Uridylate synthase is a bifunctional protein that first forms orotidine 5"-phosphate (OMP) from orotate via its orotate phosphoribosyltransferase activity (EC 2.4.2.10) and then converts OMP to uridine 5"-phosphate (UMP) via the OMP decarboxylase activity (EC 4.1.1.23). Uridine Monophosphate 194-214 olfactory marker protein Homo sapiens 86-89 3651388-2 1987 Uridylate synthase is a bifunctional protein that first forms orotidine 5"-phosphate (OMP) from orotate via its orotate phosphoribosyltransferase activity (EC 2.4.2.10) and then converts OMP to uridine 5"-phosphate (UMP) via the OMP decarboxylase activity (EC 4.1.1.23). Uridine Monophosphate 194-214 uridine monophosphate synthetase Homo sapiens 112-145 3651388-2 1987 Uridylate synthase is a bifunctional protein that first forms orotidine 5"-phosphate (OMP) from orotate via its orotate phosphoribosyltransferase activity (EC 2.4.2.10) and then converts OMP to uridine 5"-phosphate (UMP) via the OMP decarboxylase activity (EC 4.1.1.23). Uridine Monophosphate 216-219 olfactory marker protein Homo sapiens 86-89 3651388-2 1987 Uridylate synthase is a bifunctional protein that first forms orotidine 5"-phosphate (OMP) from orotate via its orotate phosphoribosyltransferase activity (EC 2.4.2.10) and then converts OMP to uridine 5"-phosphate (UMP) via the OMP decarboxylase activity (EC 4.1.1.23). Uridine Monophosphate 216-219 uridine monophosphate synthetase Homo sapiens 112-145 3839509-1 1985 The multifunctional protein uridine 5"-monophosphate (UMP) synthase catalyzes the final two reactions of the de novo biosynthesis of UMP in mammalian cells by the sequential action of orotate phosphoribosyltransferase (EC 2.4.2.10) and orotidine 5"-monophosphate (OMP) decarboxylase (EC 4.1.1.23). Uridine Monophosphate 28-52 uridine monophosphate synthetase Homo sapiens 184-217 3835824-11 1985 Pretreatment of hepatoma cells or of TA3-mammary tumor cells with an uridylate-trapping sugar analog in combination with an inhibitor of de novo pyrimidine synthesis enhances the uptake of 5-fluorouridine, its incorporation into RNA, and its growth inhibitory effect. Uridine Monophosphate 69-78 trace amine-associated receptor 9 Rattus norvegicus 37-40 6468388-15 1984 This simulation shows that on addition of BMP, there is a sequential depletion of all pyrimidine intermediates between UMP and dCDP and a concomitant accumulation of OMP. Uridine Monophosphate 119-122 bone morphogenetic protein 1 Homo sapiens 42-45 6373042-2 1984 Although 3-MeC was promutagenic with the RNA polymerase incorporating both AMP and UMP in the ratio of approximately 5:1 (agreeing with results reported by earlier workers) no non-complementary nucleotide incorporation was observed with DNA polymerase I. Uridine Monophosphate 83-86 C-C motif chemokine ligand 28 Homo sapiens 11-14 6534379-8 1984 Pretreatment of rats with uridine-5"-phosphate improving long-term memory formation resulted in an augmentation of L-leucine incorporation into proteins of CA 1 and CA 3 of trained animals when compared to controls, whilst in other hippocampal subregions no differences in incorporation rates were found between trained and nontrained rats. Uridine Monophosphate 26-46 carbonic anhydrase 1 Rattus norvegicus 156-160 6534379-8 1984 Pretreatment of rats with uridine-5"-phosphate improving long-term memory formation resulted in an augmentation of L-leucine incorporation into proteins of CA 1 and CA 3 of trained animals when compared to controls, whilst in other hippocampal subregions no differences in incorporation rates were found between trained and nontrained rats. Uridine Monophosphate 26-46 carbonic anhydrase 3 Rattus norvegicus 165-169 6345657-12 1983 Uridine monophosphate, which is much less inhibitory to the galactosyltransferase than UDP, is then transported out of the lumen by a second carrier and is broken down further to uridine by 5"-nucleotidase on the cytoplasmic side of the Golgi vesicles. Uridine Monophosphate 0-21 glycoprotein alpha-galactosyltransferase 1 Rattus norvegicus 60-81 6345657-12 1983 Uridine monophosphate, which is much less inhibitory to the galactosyltransferase than UDP, is then transported out of the lumen by a second carrier and is broken down further to uridine by 5"-nucleotidase on the cytoplasmic side of the Golgi vesicles. Uridine Monophosphate 0-21 5' nucleotidase, ecto Rattus norvegicus 190-205 7006681-0 1980 Inhibition of orotidine-5"-phosphate decarboxylase by 1-(5"-phospho-beta-d-ribofuranosyl)barbituric acid, 6-azauridine 5"-phosphate, and uridine 5"-phosphate. Uridine Monophosphate 111-131 uridine monophosphate synthetase Homo sapiens 14-50 6256803-2 1980 AC4"-centered radical in the ribose moiety of uridine-5"-phosphate single crystals. Uridine Monophosphate 46-66 adenylate cyclase 4 Homo sapiens 0-3 819433-9 1976 The ecto-5"-nucleotidase readily hydrolyzed 5"-AMP and 5"-UMP. Uridine Monophosphate 55-61 5' nucleotidase, ecto Rattus norvegicus 4-24 5032526-1 1972 Allopurinol therapy in man interferes with pyrimidine biosynthesis de novo by inhibition of one or both of the two enzymes, orotate phosphoribosyltransferase (OPRT) and orotidylic decarboxylase (ODC), responsible for the conversion of orotic acid to uridine-5"-monophosphate. Uridine Monophosphate 250-274 uridine monophosphate synthetase Homo sapiens 124-157 5032526-1 1972 Allopurinol therapy in man interferes with pyrimidine biosynthesis de novo by inhibition of one or both of the two enzymes, orotate phosphoribosyltransferase (OPRT) and orotidylic decarboxylase (ODC), responsible for the conversion of orotic acid to uridine-5"-monophosphate. Uridine Monophosphate 250-274 ornithine decarboxylase 1 Homo sapiens 169-193 5674051-5 1968 The initial stage in peptidoglycan synthesis is catalyzed by phospho-N-acetyl(NAc)muramyl-pentapeptide translocase (uridine 5"-phosphate) according to the reaction: UDP-NAc-muramyl-pentapeptide + acceptor right arrow over left arrow acceptor-phospho-NAc-muramyl-pentapeptide + UMP where acceptor is C(55)-isoprenoid alcohol phosphate. Uridine Monophosphate 116-136 synuclein alpha Homo sapiens 78-81 5674051-5 1968 The initial stage in peptidoglycan synthesis is catalyzed by phospho-N-acetyl(NAc)muramyl-pentapeptide translocase (uridine 5"-phosphate) according to the reaction: UDP-NAc-muramyl-pentapeptide + acceptor right arrow over left arrow acceptor-phospho-NAc-muramyl-pentapeptide + UMP where acceptor is C(55)-isoprenoid alcohol phosphate. Uridine Monophosphate 116-136 synuclein alpha Homo sapiens 169-172 5674051-5 1968 The initial stage in peptidoglycan synthesis is catalyzed by phospho-N-acetyl(NAc)muramyl-pentapeptide translocase (uridine 5"-phosphate) according to the reaction: UDP-NAc-muramyl-pentapeptide + acceptor right arrow over left arrow acceptor-phospho-NAc-muramyl-pentapeptide + UMP where acceptor is C(55)-isoprenoid alcohol phosphate. Uridine Monophosphate 116-136 synuclein alpha Homo sapiens 169-172 5674051-7 1968 In addition to the transfer reaction, the enzyme catalyzes the exchange of [(3)H]uridine monophosphate (UMP) with UDP-NAc-muramyl-pentapeptide. Uridine Monophosphate 104-107 synuclein alpha Homo sapiens 118-121 33450490-2 2021 Human antigen R (HuR), an RNA-binding protein, is overexpressed in many cancers and regulates the mRNAs of multiple angiogenic factors by binding to the adenylate-uridylate-rich element in their 3" untranslated region. Uridine Monophosphate 163-172 ELAV like RNA binding protein 1 Homo sapiens 17-20 32879160-2 2020 CD26 expression in follicular tumor-uncertain malignant potential (FT-UMP) is reported to be clearly higher than in that without capsular invasion. Uridine Monophosphate 69-73 dipeptidyl peptidase 4 Homo sapiens 0-4 32611766-5 2020 We found that AHR knockdown reduced lactate, S-lactoylglutathione, N-acetyl-l-alanine, 2-hydroxyglutarate, and UMP levels. Uridine Monophosphate 111-114 aryl hydrocarbon receptor Homo sapiens 14-17 32611766-7 2020 AHR knockdown in glioblastoma cells also reduced the expression of LDHA (and lactate), DHODH, and UMPS but did not affect UMP levels, likely because of compensatory mechanisms in these cells. Uridine Monophosphate 98-101 aryl hydrocarbon receptor Homo sapiens 0-3 32462970-10 2021 Comparative structural analysis showed the stronger binding of EndoU to Glisoxepide and Idarubicin than to uridine monophosphate (UMP). Uridine Monophosphate 107-128 endonuclease, poly(U) specific Homo sapiens 63-68 32462970-10 2021 Comparative structural analysis showed the stronger binding of EndoU to Glisoxepide and Idarubicin than to uridine monophosphate (UMP). Uridine Monophosphate 130-133 endonuclease, poly(U) specific Homo sapiens 63-68 32277574-2 2020 The causative gene has been identified as calcium-activated nucleotidase 1 (CANT1), which encodes a nucleotidase that preferentially hydrolyzes UDP to UMP and phosphate. Uridine Monophosphate 151-154 calcium activated nucleotidase 1 Mus musculus 42-74 32277574-2 2020 The causative gene has been identified as calcium-activated nucleotidase 1 (CANT1), which encodes a nucleotidase that preferentially hydrolyzes UDP to UMP and phosphate. Uridine Monophosphate 151-154 calcium activated nucleotidase 1 Mus musculus 76-81 31832688-6 2020 We show that K. marxianus Usb1 enzyme has CPDase activity and determined its structure, free and bound to the substrate analog uridine 5"-monophosphate. Uridine Monophosphate 127-151 phosphoric diester hydrolase Saccharomyces cerevisiae S288C 26-30 31431503-5 2019 LC/MS/MS metabolomics analysis revealed that AICAr increases orotate levels and decreases uridine monophosphate (UMP) levels, consistent with inhibition of UMP synthesis at a step downstream of dihydroorotate dehydrogenase (DHODH). Uridine Monophosphate 90-111 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Homo sapiens 45-50 31431503-5 2019 LC/MS/MS metabolomics analysis revealed that AICAr increases orotate levels and decreases uridine monophosphate (UMP) levels, consistent with inhibition of UMP synthesis at a step downstream of dihydroorotate dehydrogenase (DHODH). Uridine Monophosphate 113-116 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Homo sapiens 45-50 31177538-7 2019 Conversely, claudin-1 expression in the duodenum mucosa was inhibited (P < 0.05) by dietary supplementation with UMP or UR. Uridine Monophosphate 113-116 claudin 1 Homo sapiens 12-21 31118275-0 2019 Conserved Glu-47 and Lys-50 residues are critical for UDP-N-acetylglucosamine/UMP antiport activity of the mouse Golgi-associated transporter Slc35a3. Uridine Monophosphate 78-81 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3 Mus musculus 142-149 30304569-1 2019 Uridine-cytidine kinases (encoded by UCK1, UCKL1, and UCK2) catalyze the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP). Uridine Monophosphate 116-137 uridine-cytidine kinase 1 Homo sapiens 37-41 30304569-1 2019 Uridine-cytidine kinases (encoded by UCK1, UCKL1, and UCK2) catalyze the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP). Uridine Monophosphate 116-137 uridine-cytidine kinase 1 like 1 Homo sapiens 43-48 30304569-1 2019 Uridine-cytidine kinases (encoded by UCK1, UCKL1, and UCK2) catalyze the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP). Uridine Monophosphate 116-137 uridine-cytidine kinase 2 Homo sapiens 54-58 30304569-1 2019 Uridine-cytidine kinases (encoded by UCK1, UCKL1, and UCK2) catalyze the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP). Uridine Monophosphate 139-142 uridine-cytidine kinase 1 Homo sapiens 37-41 30304569-1 2019 Uridine-cytidine kinases (encoded by UCK1, UCKL1, and UCK2) catalyze the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP). Uridine Monophosphate 139-142 uridine-cytidine kinase 1 like 1 Homo sapiens 43-48 30304569-1 2019 Uridine-cytidine kinases (encoded by UCK1, UCKL1, and UCK2) catalyze the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP). Uridine Monophosphate 139-142 uridine-cytidine kinase 2 Homo sapiens 54-58 29551634-4 2018 RESULTS: Xbp1s is a key molecule involved in adipocyte uridine biosynthesis and release by activation of carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, dihydroorotase (CAD), the rate-limiting enzyme for UMP biosynthesis. Uridine Monophosphate 218-221 X-box binding protein 1 Mus musculus 9-13 29413322-2 2018 Here we show that human NUDT22 is a Mg2+-dependent UDP-glucose and UDP-galactose hydrolase, producing UMP and glucose 1-phosphate or galactose 1-phosphate. Uridine Monophosphate 102-105 nudix hydrolase 22 Homo sapiens 24-30 28688178-11 2017 Among the PI3K-Akt targets, 75% could be explained by a deactivation of adenylate-uridylate-rich element (ARE)-binding protein BRF1, a target of PI3K-Akt. Uridine Monophosphate 82-91 thymoma viral proto-oncogene 1 Mus musculus 15-18 28688178-11 2017 Among the PI3K-Akt targets, 75% could be explained by a deactivation of adenylate-uridylate-rich element (ARE)-binding protein BRF1, a target of PI3K-Akt. Uridine Monophosphate 82-91 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit Mus musculus 127-131 28688178-11 2017 Among the PI3K-Akt targets, 75% could be explained by a deactivation of adenylate-uridylate-rich element (ARE)-binding protein BRF1, a target of PI3K-Akt. Uridine Monophosphate 82-91 thymoma viral proto-oncogene 1 Mus musculus 150-153 30035254-2 2017 HuR can stabilize target mRNAs and/or promote translation by interacting with their 3" untranslated region adenylate and uridylate-rich elements. Uridine Monophosphate 121-130 ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) Mus musculus 0-3 28993718-4 2017 The procedure for estimating the pKa of uridine 5"-phosphate for C-6 deprotonation at the active site of orotidine 5"-phosphate decarboxylase is described, and the effect of a 5-F substituent on carbon acidity of the enzyme-bound substrate is discussed. Uridine Monophosphate 40-60 uridine monophosphate synthetase Homo sapiens 105-141 27906623-1 2016 Orotate (OA) is well-known as a precursor in biosynthesis of pyrimidines; in mammals it is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Uridine Monophosphate 178-181 dihydroorotate dehydrogenase (quinone) Homo sapiens 123-151 27906623-1 2016 Orotate (OA) is well-known as a precursor in biosynthesis of pyrimidines; in mammals it is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Uridine Monophosphate 178-181 dihydroorotate dehydrogenase (quinone) Homo sapiens 153-158 27826622-3 2016 AUF1 influences the process of development, apoptosis and tumorigenesis via interacting with adenylate-uridylate rich elements (AREs) bearing mRNAs. Uridine Monophosphate 103-112 heterogeneous nuclear ribonucleoprotein D Homo sapiens 0-4 27178326-3 2016 We took advantage of a "designer" mouse with dysregulation of interferon gamma (IFNgamma) characterized by prolonged and chronic expression of IFNgamma through deletion of the IFNgamma 3"-untranslated region adenylate uridylate-rich element (ARE). Uridine Monophosphate 218-227 interferon gamma Mus musculus 62-89 27178326-3 2016 We took advantage of a "designer" mouse with dysregulation of interferon gamma (IFNgamma) characterized by prolonged and chronic expression of IFNgamma through deletion of the IFNgamma 3"-untranslated region adenylate uridylate-rich element (ARE). Uridine Monophosphate 218-227 interferon gamma Mus musculus 80-88 27178326-3 2016 We took advantage of a "designer" mouse with dysregulation of interferon gamma (IFNgamma) characterized by prolonged and chronic expression of IFNgamma through deletion of the IFNgamma 3"-untranslated region adenylate uridylate-rich element (ARE). Uridine Monophosphate 218-227 interferon gamma Mus musculus 143-151 26679082-6 2016 CONCLUSION: Uridine monophosphate + folic acid + vitamin B12 reduced total pain score, intensity and characterization of pain and associated symptoms. Uridine Monophosphate 12-33 NADH:ubiquinone oxidoreductase subunit B3 Homo sapiens 57-60 26271729-1 2015 Uracil phosphoribosyltransferase (UPRT) is a pyrimidine salvage pathway enzyme that catalyzes the conversion of uracil to uridine monophosphate (UMP). Uridine Monophosphate 122-143 krishah Drosophila melanogaster 34-38 26271729-1 2015 Uracil phosphoribosyltransferase (UPRT) is a pyrimidine salvage pathway enzyme that catalyzes the conversion of uracil to uridine monophosphate (UMP). Uridine Monophosphate 145-148 krishah Drosophila melanogaster 34-38 25841336-1 2015 Human antigen R (HuR) is a ubiquitous 32 kDa protein comprising three RNA Recognition Motifs (RRMs), whose main function is to bind Adenylate and uridylate Rich Elements (AREs) in 3" UnTranslated Regions (UTRs) of mRNAs. Uridine Monophosphate 146-155 ELAV like RNA binding protein 1 Homo sapiens 0-15 25841336-1 2015 Human antigen R (HuR) is a ubiquitous 32 kDa protein comprising three RNA Recognition Motifs (RRMs), whose main function is to bind Adenylate and uridylate Rich Elements (AREs) in 3" UnTranslated Regions (UTRs) of mRNAs. Uridine Monophosphate 146-155 ELAV like RNA binding protein 1 Homo sapiens 17-20 25293769-6 2014 Ribonucleoprotein complex immunoprecipitation and biotinylated RNA pull-down assays demonstrated that PARP-14 forms a complex with the mRNA-destabilizing protein tristetraprolin (TTP) and a conserved adenylate-uridylate-rich element in the TF mRNA 3" untranslated region. Uridine Monophosphate 210-219 poly (ADP-ribose) polymerase family, member 14 Mus musculus 102-109 25293769-6 2014 Ribonucleoprotein complex immunoprecipitation and biotinylated RNA pull-down assays demonstrated that PARP-14 forms a complex with the mRNA-destabilizing protein tristetraprolin (TTP) and a conserved adenylate-uridylate-rich element in the TF mRNA 3" untranslated region. Uridine Monophosphate 210-219 zinc finger protein 36 Mus musculus 162-177 25366766-2 2014 Two single-nucleotide polymorphisms (SNPs) in the thymidylate synthase (TS) gene, the 28-base pair (bp) tandem repeat in the TS 5"-untranslated enhanced region (TSER) and the 6-bp insertion/deletion in the TS 3"-untranslated region (TS 3"-UTR), increase the rate of misincorporation of uridylate into DNA and may lead to chromosomal damage. Uridine Monophosphate 286-295 thymidylate synthetase Homo sapiens 50-70 25366766-2 2014 Two single-nucleotide polymorphisms (SNPs) in the thymidylate synthase (TS) gene, the 28-base pair (bp) tandem repeat in the TS 5"-untranslated enhanced region (TSER) and the 6-bp insertion/deletion in the TS 3"-untranslated region (TS 3"-UTR), increase the rate of misincorporation of uridylate into DNA and may lead to chromosomal damage. Uridine Monophosphate 286-295 thymidylate synthetase Homo sapiens 72-74 25366766-2 2014 Two single-nucleotide polymorphisms (SNPs) in the thymidylate synthase (TS) gene, the 28-base pair (bp) tandem repeat in the TS 5"-untranslated enhanced region (TSER) and the 6-bp insertion/deletion in the TS 3"-untranslated region (TS 3"-UTR), increase the rate of misincorporation of uridylate into DNA and may lead to chromosomal damage. Uridine Monophosphate 286-295 thymidylate synthetase Homo sapiens 125-127 25366766-2 2014 Two single-nucleotide polymorphisms (SNPs) in the thymidylate synthase (TS) gene, the 28-base pair (bp) tandem repeat in the TS 5"-untranslated enhanced region (TSER) and the 6-bp insertion/deletion in the TS 3"-untranslated region (TS 3"-UTR), increase the rate of misincorporation of uridylate into DNA and may lead to chromosomal damage. Uridine Monophosphate 286-295 thymidylate synthetase Homo sapiens 125-127 25366766-2 2014 Two single-nucleotide polymorphisms (SNPs) in the thymidylate synthase (TS) gene, the 28-base pair (bp) tandem repeat in the TS 5"-untranslated enhanced region (TSER) and the 6-bp insertion/deletion in the TS 3"-untranslated region (TS 3"-UTR), increase the rate of misincorporation of uridylate into DNA and may lead to chromosomal damage. Uridine Monophosphate 286-295 thymidylate synthetase Homo sapiens 125-127 25340302-4 2014 Compounds 1 and 2 formed markedly stable mixed-ligand Pd2+ complexes with UMP and GMP, UMP binding favored by 1 and GMP by 2. Uridine Monophosphate 74-77 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 54-57 25340302-4 2014 Compounds 1 and 2 formed markedly stable mixed-ligand Pd2+ complexes with UMP and GMP, UMP binding favored by 1 and GMP by 2. Uridine Monophosphate 87-90 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 54-57 25010987-3 2014 Unexpectedly, crosslinking-RNP and RNA probe pull-down experiments revealed that HuR binds exclusively to the caspase-2-5" untranslated region (UTR) despite that the 3" UTR of the mRNA bears several adenylate- and uridylate-rich elements representing the prototypical HuR binding sites. Uridine Monophosphate 214-223 ELAV like RNA binding protein 1 Homo sapiens 81-84 24637557-7 2014 Human antigen R bound with the adenylate-uridylate-rich elements of caveolin-1 mRNA 3" untranslated region, resulting in the increased stability of caveolin-1, and genetic knockdown of human antigen R decreased the expression of caveolin-1 in LKB1-deficient endothelial cells. Uridine Monophosphate 41-50 caveolin 1, caveolae protein Mus musculus 68-78 24637557-7 2014 Human antigen R bound with the adenylate-uridylate-rich elements of caveolin-1 mRNA 3" untranslated region, resulting in the increased stability of caveolin-1, and genetic knockdown of human antigen R decreased the expression of caveolin-1 in LKB1-deficient endothelial cells. Uridine Monophosphate 41-50 caveolin 1, caveolae protein Mus musculus 148-158 24637557-7 2014 Human antigen R bound with the adenylate-uridylate-rich elements of caveolin-1 mRNA 3" untranslated region, resulting in the increased stability of caveolin-1, and genetic knockdown of human antigen R decreased the expression of caveolin-1 in LKB1-deficient endothelial cells. Uridine Monophosphate 41-50 caveolin 1, caveolae protein Mus musculus 148-158 25584704-1 2014 Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Uridine Monophosphate 108-117 ELAV like RNA binding protein 1 Homo sapiens 0-15 25584704-1 2014 Human antigen R (HuR) is a 32 kDa protein with 3 RNA Recognition Motifs (RRMs), which bind to Adenylate and uridylate Rich Elements (AREs) of mRNAs. Uridine Monophosphate 108-117 ELAV like RNA binding protein 1 Homo sapiens 17-20 23832958-4 2013 TTP competes with the constitutively expressed protein human antigen R in binding to the mRNA destabilizing adenylate-uridylate -rich element. Uridine Monophosphate 118-127 ZFP36 ring finger protein Homo sapiens 0-3 23585020-3 2013 The most striking abnormality was a 26-fold increase in orotate associated with a decrease in uridine monophosphate (UMP) levels, indicating an inhibition of UMP synthetase (UMPS), the last enzyme in the de novo pyrimidine biosynthetic pathway, which produces UMP from orotate and 5-phosphoribosyl-alpha-pyrophosphate (PRPP). Uridine Monophosphate 94-115 uridine monophosphate synthetase Homo sapiens 158-172 23585020-3 2013 The most striking abnormality was a 26-fold increase in orotate associated with a decrease in uridine monophosphate (UMP) levels, indicating an inhibition of UMP synthetase (UMPS), the last enzyme in the de novo pyrimidine biosynthetic pathway, which produces UMP from orotate and 5-phosphoribosyl-alpha-pyrophosphate (PRPP). Uridine Monophosphate 94-115 uridine monophosphate synthetase Homo sapiens 174-178 23585020-3 2013 The most striking abnormality was a 26-fold increase in orotate associated with a decrease in uridine monophosphate (UMP) levels, indicating an inhibition of UMP synthetase (UMPS), the last enzyme in the de novo pyrimidine biosynthetic pathway, which produces UMP from orotate and 5-phosphoribosyl-alpha-pyrophosphate (PRPP). Uridine Monophosphate 117-120 uridine monophosphate synthetase Homo sapiens 158-172 23585020-3 2013 The most striking abnormality was a 26-fold increase in orotate associated with a decrease in uridine monophosphate (UMP) levels, indicating an inhibition of UMP synthetase (UMPS), the last enzyme in the de novo pyrimidine biosynthetic pathway, which produces UMP from orotate and 5-phosphoribosyl-alpha-pyrophosphate (PRPP). Uridine Monophosphate 117-120 uridine monophosphate synthetase Homo sapiens 174-178 22925580-4 2012 This report describes the first X-ray structure of a catalytically inactivated variant of murine cN-III with a natural substrate, uridine 5"-monophosphate, in the active site at 1.74A resolution. Uridine Monophosphate 130-154 5'-nucleotidase, cytosolic III Mus musculus 97-103 22372570-7 2012 While the 3"-untranslated region of MKP-1 contains adenylate + uridylate elements responsible for regulation at the post-transcriptional level, actinomycin D chase experiments revealed that there was no increase in MKP-1 mRNA stability in the presence of dexamethasone, formoterol, alone or in combination. Uridine Monophosphate 63-72 dual specificity phosphatase 1 Homo sapiens 36-41 22504181-6 2012 AvrAC is a uridylyl transferase that adds uridine 5"-monophosphate to and conceals conserved phosphorylation sites in the activation loop of BIK1 and RIPK, reducing their kinase activity and consequently inhibiting downstream signalling. Uridine Monophosphate 42-66 botrytis-induced kinase1 Arabidopsis thaliana 141-145 24116273-7 2012 TNF-alpha mRNA stability analysis using reporter construct containing TNF-alpha adenylate/uridylate-rich elements (AREs) shows that rapamycin destabilizes TNF-alpha mRNA via regulating the AU-rich element of TNF-alpha mRNA. Uridine Monophosphate 90-99 tumor necrosis factor Rattus norvegicus 0-9 22972349-2 2012 GMP was effective only among GMP, CMP, dTMP, and UMP. Uridine Monophosphate 49-52 5'-nucleotidase, cytosolic II Homo sapiens 0-3 21821827-4 2011 Conventional calcium mobilization and nonconventional cellular impedance functional assays revealed that UMP and UDP selectively activated HEK cells coexpressing P2Y14 and Galpha(qi5). Uridine Monophosphate 105-108 purinergic receptor P2Y14 Homo sapiens 162-167 21821827-4 2011 Conventional calcium mobilization and nonconventional cellular impedance functional assays revealed that UMP and UDP selectively activated HEK cells coexpressing P2Y14 and Galpha(qi5). Uridine Monophosphate 105-108 succinate-CoA ligase GDP/ADP-forming subunit alpha Homo sapiens 172-178 21821827-7 2011 UDP-Glc, UMP, and UDP dose dependently inhibited [(3)H]UDP binding in the binding assay, and saturation analysis revealed that UDP bound P2Y14 with a K(D) = 10 nM and a B(max) = 110 pmol/mg. Uridine Monophosphate 9-12 purinergic receptor P2Y14 Homo sapiens 137-142 21819104-3 2011 The cumulative results reveal a unique ribosylation pathway that is highlighted by, among other features, uridine-5"-monophosphate as the source of the sugar, a phosphorylase strategy to generate a sugar-1-phosphate, and a primary amine-requiring nucleotidylyltransferase that generates the NDP-sugar donor. Uridine Monophosphate 106-130 norrin cystine knot growth factor NDP Homo sapiens 291-294 21417463-0 2011 Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. Uridine Monophosphate 28-31 purinergic receptor P2Y2 Homo sapiens 88-92 21417463-0 2011 Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors. Uridine Monophosphate 28-31 pyrimidinergic receptor P2Y4 Homo sapiens 94-98 21417463-2 2011 2-(Ar)alkylthio substitution of UMP and UDP was best tolerated by the P2Y(2) receptor. Uridine Monophosphate 32-35 purinergic receptor P2Y2 Homo sapiens 70-76 21268116-0 2011 Crystal structure of the pyrimidine 5"-nucleotidase SDT1 from Saccharomyces cerevisiae complexed with uridine 5"-monophosphate provides further insight into ligand binding. Uridine Monophosphate 102-126 nucleotidase Saccharomyces cerevisiae S288C 52-56 21074248-4 2010 ENTPD5 hydrolyzes UDP to UMP to promote protein N-glycosylation and folding in ER. Uridine Monophosphate 25-28 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) Homo sapiens 0-6 20722631-6 2010 Purified human recombinant HDHD1 dephosphorylated pseudouridine 5"-phosphate with a kcat of 1.6 s-1, a Km of 0.3 muM and a catalytic efficiency at least 1000-fold higher than that on which it acted on other phosphate esters, including 5"-UMP. Uridine Monophosphate 235-241 pseudouridine 5'-phosphatase Homo sapiens 27-32 20427483-7 2010 In addition, we cloned the entire NUCB2 gene and identified four adenylate/uridylate-rich elements (AREs) in the 3" untranslated region (UTR), to which several proteins of HTB185 extracts treated with TZ bound. Uridine Monophosphate 75-84 nucleobindin 2 Homo sapiens 34-39 20392207-2 2010 For the latter case, inherent PAI-2 mRNA instability was previously shown to require a nonameric adenylate-uridylate element in the 3" UTR. Uridine Monophosphate 107-116 serpin family B member 2 Homo sapiens 30-35 20124705-1 2010 Bovine pancreatic ribonuclease A (RNase A) was crystallized from a mixture of small molecules containing basic fuchsin, tobramycin and uridine 5"-monophosphate (U5P). Uridine Monophosphate 135-159 ribonuclease pancreatic Bos taurus 18-32 20124705-1 2010 Bovine pancreatic ribonuclease A (RNase A) was crystallized from a mixture of small molecules containing basic fuchsin, tobramycin and uridine 5"-monophosphate (U5P). Uridine Monophosphate 135-159 ribonuclease pancreatic Bos taurus 34-41 20124705-1 2010 Bovine pancreatic ribonuclease A (RNase A) was crystallized from a mixture of small molecules containing basic fuchsin, tobramycin and uridine 5"-monophosphate (U5P). Uridine Monophosphate 161-164 ribonuclease pancreatic Bos taurus 18-32 20124705-1 2010 Bovine pancreatic ribonuclease A (RNase A) was crystallized from a mixture of small molecules containing basic fuchsin, tobramycin and uridine 5"-monophosphate (U5P). Uridine Monophosphate 161-164 ribonuclease pancreatic Bos taurus 34-41 19643076-2 2010 This reaction catalyzed by thyA or TYMS encoded thymidylate synthases is the last committed step in the biosynthesis of thymidylate and proceeds via the reductive methylation of uridylate. Uridine Monophosphate 178-187 thymidylate synthetase Homo sapiens 35-39 20163622-1 2009 5"-Uridylic acid (UMP), which is present at high concentrations in cow"s colostrum, has been shown to cause a reduction in increased plasma levels of insulin and glucose after ingestion of milk replacer in pre-weaning calves. Uridine Monophosphate 0-16 insulin Bos taurus 150-157 20163622-1 2009 5"-Uridylic acid (UMP), which is present at high concentrations in cow"s colostrum, has been shown to cause a reduction in increased plasma levels of insulin and glucose after ingestion of milk replacer in pre-weaning calves. Uridine Monophosphate 18-21 insulin Bos taurus 150-157 19574636-1 2009 In the quest for the rational design of selective and potent inhibitors for members of the pancreatic ribonuclease A (RNase A) family of biomedical interest, the binding of uridine 5"-phosphate (U5P) and uridine 5"-diphosphate (UDP) to RNase A have been investigated using kinetic studies and X-ray crystallography. Uridine Monophosphate 173-193 ribonuclease A family member 1, pancreatic Homo sapiens 102-116 19574636-1 2009 In the quest for the rational design of selective and potent inhibitors for members of the pancreatic ribonuclease A (RNase A) family of biomedical interest, the binding of uridine 5"-phosphate (U5P) and uridine 5"-diphosphate (UDP) to RNase A have been investigated using kinetic studies and X-ray crystallography. Uridine Monophosphate 173-193 ribonuclease A family member 1, pancreatic Homo sapiens 118-125 19574636-1 2009 In the quest for the rational design of selective and potent inhibitors for members of the pancreatic ribonuclease A (RNase A) family of biomedical interest, the binding of uridine 5"-phosphate (U5P) and uridine 5"-diphosphate (UDP) to RNase A have been investigated using kinetic studies and X-ray crystallography. Uridine Monophosphate 173-193 ribonuclease A family member 1, pancreatic Homo sapiens 236-243 19574636-1 2009 In the quest for the rational design of selective and potent inhibitors for members of the pancreatic ribonuclease A (RNase A) family of biomedical interest, the binding of uridine 5"-phosphate (U5P) and uridine 5"-diphosphate (UDP) to RNase A have been investigated using kinetic studies and X-ray crystallography. Uridine Monophosphate 195-198 ribonuclease A family member 1, pancreatic Homo sapiens 102-116 19574636-1 2009 In the quest for the rational design of selective and potent inhibitors for members of the pancreatic ribonuclease A (RNase A) family of biomedical interest, the binding of uridine 5"-phosphate (U5P) and uridine 5"-diphosphate (UDP) to RNase A have been investigated using kinetic studies and X-ray crystallography. Uridine Monophosphate 195-198 ribonuclease A family member 1, pancreatic Homo sapiens 118-125 19345675-1 2009 In the nucleus HuR binds to mRNAs containing adenylate-uridylate rich elements in the 3"-untranslated region. Uridine Monophosphate 55-64 ELAV like RNA binding protein 1 Homo sapiens 15-18 18761383-4 2008 UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Uridine Monophosphate 0-3 tyrosine hydroxylase Rattus norvegicus 101-121 18761383-4 2008 UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Uridine Monophosphate 0-3 tyrosine hydroxylase Rattus norvegicus 123-125 18761383-4 2008 UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Uridine Monophosphate 0-3 tyrosine hydroxylase Rattus norvegicus 137-139 18761383-4 2008 UMP/DHA treatment reduced ipsilateral rotations by 57% and significantly elevated striatal dopamine, tyrosine hydroxylase (TH) activity, TH protein and synapsin-1 on the lesioned side. Uridine Monophosphate 0-3 synapsin I Rattus norvegicus 152-162 18279945-2 2008 OBJECTIVE: We investigated IL-13 posttranscriptional regulation by HuR, a protein associating with adenylate-uridylate-rich elements in the 3" untranslated regions (UTRs) of mRNA, promoting mRNA stability and translation. Uridine Monophosphate 109-118 interleukin 13 Homo sapiens 27-32 18279945-2 2008 OBJECTIVE: We investigated IL-13 posttranscriptional regulation by HuR, a protein associating with adenylate-uridylate-rich elements in the 3" untranslated regions (UTRs) of mRNA, promoting mRNA stability and translation. Uridine Monophosphate 109-118 ELAV like RNA binding protein 1 Homo sapiens 67-70 18067323-6 2008 ST3Gal-II also catalyzed the conversion of 5"-uridine monophosphate (UMP) to UMP-NeuAc, which was found to be an inactive sialyl donor. Uridine Monophosphate 69-72 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 Homo sapiens 0-9 17967036-6 2007 These sulfite addition reactions, which are slowly reversible and are not catalyzed by the enzyme, result in the appearance of one (or, in the case of OMP, two) bulky anionic substituents at the 6-carbon atom of UMP. Uridine Monophosphate 212-215 olfactory marker protein Homo sapiens 151-154 17288991-1 2007 HuR is a ligand for nuclear mRNAs containing adenylate-uridylate rich elements in the 3"-untranslated region. Uridine Monophosphate 55-64 ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) Mus musculus 0-3 17234598-8 2007 A combination of approaches performed using the region that directly encompasses an adenylate and uridylate (AU)-rich element within the AChE 3"-untranslated region demonstrated a decrease in RNA-protein complexes in response to axotomy of the SCG and, specifically, a decrease in HuD binding. Uridine Monophosphate 98-107 acetylcholinesterase Mus musculus 137-141 17384901-1 2007 Uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate, is important in the pyrimidine salvage pathway and is an attractive target for rational drug design by incorporation of prodrugs that are lethal to many parasitic organisms specifically. Uridine Monophosphate 115-136 uracil phosphoribosyltransferase Arabidopsis thaliana 0-32 16490218-0 2006 Oral administration of uridylic acid increases plasma leptin, but suppresses glucose and non-esterified fatty acid concentrations in rats. Uridine Monophosphate 23-36 leptin Rattus norvegicus 54-60 16490218-2 2006 In the present study, in order to investigate the effects of oral ingestion of uridylic acid (5"-uridine monophosphate, 5"-UMP) on hormonal and metabolic levels, we measured changes in the plasma concentrations of leptin, insulin, glucose, non-esterified fatty acids (NEFA), weights of the liver and abdominal fat and fat accumulation in the liver and M. gastrocnemius in male rats. Uridine Monophosphate 79-92 leptin Rattus norvegicus 214-220 16490218-2 2006 In the present study, in order to investigate the effects of oral ingestion of uridylic acid (5"-uridine monophosphate, 5"-UMP) on hormonal and metabolic levels, we measured changes in the plasma concentrations of leptin, insulin, glucose, non-esterified fatty acids (NEFA), weights of the liver and abdominal fat and fat accumulation in the liver and M. gastrocnemius in male rats. Uridine Monophosphate 120-126 leptin Rattus norvegicus 214-220 16490218-7 2006 In summary, acute oral administration of 5"-UMP was effective in the rat in reducing plasma concentrations of glucose and NEFA, an effect that was accompanied by an elevated plasma leptin concentration. Uridine Monophosphate 41-47 leptin Rattus norvegicus 181-187 16126180-0 2005 Oral uridine-5"-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Uridine Monophosphate 5-29 cut like homeobox 1 Homo sapiens 52-55 16126180-0 2005 Oral uridine-5"-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Uridine Monophosphate 31-34 cut like homeobox 1 Homo sapiens 52-55 16126180-8 2005 These results show that oral UMP, a uridine source, enhances the synthesis of CDP-choline, the immediate precursor of PC, in gerbil brain. Uridine Monophosphate 29-32 cut like homeobox 1 Homo sapiens 78-81 15863502-1 2005 HuR is a ligand for nuclear mRNAs containing adenylate-uridylate-rich elements in the 3"-untranslated region. Uridine Monophosphate 55-64 ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) Mus musculus 0-3 16002545-8 2005 From these results, we have concluded that feeding 5"-UMP at 2 g/day for 11 days significantly alters TAG accumulation in the body and plasma concentrations of GH and insulin in young bull calves. Uridine Monophosphate 51-57 insulin Bos taurus 167-174 15735337-2 2005 UCK2 catalyzes the phosphorylation of the natural ribonucleosides cytidine and uridine to cytidine 5"-monophosphate (CMP) and uridine 5"-monophosphate (UMP), respectively, and activates several important frontline antimetabolite drugs. Uridine Monophosphate 126-150 uridine-cytidine kinase 2 Homo sapiens 0-4 15735337-2 2005 UCK2 catalyzes the phosphorylation of the natural ribonucleosides cytidine and uridine to cytidine 5"-monophosphate (CMP) and uridine 5"-monophosphate (UMP), respectively, and activates several important frontline antimetabolite drugs. Uridine Monophosphate 152-155 uridine-cytidine kinase 2 Homo sapiens 0-4 15752360-9 2005 The data indicate that UPRTase undergoes a transition from a weakly active or inactive T-state, favored by binding of UMP and CTP, to an active R-state, favored by binding of GTP and PRPP. Uridine Monophosphate 118-121 DNA-directed RNA polymerase subunit A'' Saccharolobus solfataricus 23-30 15550676-1 2005 Human UMP/CMP kinase (cytidylate kinase; EC 2.7.4.14) is responsible for phosphorylation of CMP, UMP, and deoxycytidine monophosphate (dCMP) and also plays an important role in the activation of pyrimidine analogs, some of which are clinically useful anticancer or antiviral drugs. Uridine Monophosphate 6-9 cmp Drosophila melanogaster 10-13 15550676-8 2005 The differential regulation of dCMPK versus CMPK activities by ATP or magnesium was also seen in other 2"-deoxypyrimidine analog monophosphates (deoxyuridine monophosphate, 5-fluorodeoxyuridine monophosphate, 1-beta-D-arabinofuranosylcytosine monophosphate, and gemcitabine monophosphate) versus their ribose-counterparts (UMP and 5-fluorouridine monophosphate), in a similar manner. Uridine Monophosphate 323-326 cytidine/uridine monophosphate kinase 1 Homo sapiens 32-36 15527770-3 2004 We have solved the crystal structure of human ISG20 complexed with two Mn2+ ions and uridine 5"-monophosphate (UMP) at 1.9 A resolution. Uridine Monophosphate 85-109 interferon stimulated exonuclease gene 20 Homo sapiens 46-51 15527770-3 2004 We have solved the crystal structure of human ISG20 complexed with two Mn2+ ions and uridine 5"-monophosphate (UMP) at 1.9 A resolution. Uridine Monophosphate 111-114 interferon stimulated exonuclease gene 20 Homo sapiens 46-51 15192077-1 2004 The nucleocytoplasmic shuttling protein, A+U-rich element binding factor 1 (AUF1), is one of the RNA-binding proteins that specifically bind adenylate-uridylate rich elements (AREs) in mRNA 3"-untranslated regions (UTRs), and acts as a regulator of ARE-mediated mRNA degradation in the cytoplasm. Uridine Monophosphate 151-160 heterogeneous nuclear ribonucleoprotein D Rattus norvegicus 76-80 15102851-9 2004 We hypothesize that up-regulation of uda-1 favors hydrolysis of the glucosyltransferase inhibitory product UDP to UMP, and that the latter product then exits the lumen of the ER or pre-GA compartment in a coupled exchange with the entry of UDP-glucose, thereby further relieving ER stress by favoring protein re-glycosylation. Uridine Monophosphate 114-117 Nucleoside-diphosphatase uda-1 Caenorhabditis elegans 37-42 15147974-2 2004 Orotate phosphoribosyltransferase (OPRT) and orotidine 5"-monophosphate decarboxylase (OMPDC), the fifth and sixth enzymes in the pathway catalyzing formation of uridine 5"-monophosphate (UMP), remain largely uncharacterized in the protozoan parasite. Uridine Monophosphate 162-186 uridine monophosphate synthetase Homo sapiens 35-39 15147974-2 2004 Orotate phosphoribosyltransferase (OPRT) and orotidine 5"-monophosphate decarboxylase (OMPDC), the fifth and sixth enzymes in the pathway catalyzing formation of uridine 5"-monophosphate (UMP), remain largely uncharacterized in the protozoan parasite. Uridine Monophosphate 188-191 uridine monophosphate synthetase Homo sapiens 35-39 12706367-5 2003 Both resistant cell lines showed decreased orotate phosphoribosyltransferase (OPRT) activity, which is associated with the activity of the uridine monophosphate (UMP) synthase gene (3q13). Uridine Monophosphate 139-160 uridine monophosphate synthetase Homo sapiens 43-76 12706367-5 2003 Both resistant cell lines showed decreased orotate phosphoribosyltransferase (OPRT) activity, which is associated with the activity of the uridine monophosphate (UMP) synthase gene (3q13). Uridine Monophosphate 139-160 uridine monophosphate synthetase Homo sapiens 78-82 12671683-1 2003 A series of experiments, using cell culture models or in vitro assays, has shown that the RNA-binding protein HuR increases the half-life of some messenger RNAs that contain adenylate/uridylate-rich decay elements. Uridine Monophosphate 184-193 ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) Mus musculus 110-113 12655113-4 2003 The activities of canine erythrocyte 5"-nucleotidase measured using cytidine and uridine 5"-monophosphates, which are preferentially catalyzed by one of the human pyrimidine 5"-nucleotidase isozymes (P5N-I), were similar to those of the human enzyme. Uridine Monophosphate 81-106 5'-nucleotidase ecto Canis lupus familiaris 37-52 12655113-4 2003 The activities of canine erythrocyte 5"-nucleotidase measured using cytidine and uridine 5"-monophosphates, which are preferentially catalyzed by one of the human pyrimidine 5"-nucleotidase isozymes (P5N-I), were similar to those of the human enzyme. Uridine Monophosphate 81-106 5'-nucleotidase ecto Canis lupus familiaris 174-189 12452710-7 2002 Under moderately acidic conditions (pH 2-6), the predominant reaction is acid-catalyzed cleavage of the P-N3" bond (first-order in [H(+)]) that yields an equimolar mixture of 5 and uridine 5"-phosphate (6). Uridine Monophosphate 181-201 sodium voltage-gated channel alpha subunit 10 Homo sapiens 104-108 12440884-0 2002 Equilibrium of formation of the 6-carbanion of UMP, a potential intermediate in the action of OMP decarboxylase. Uridine Monophosphate 47-50 olfactory marker protein Homo sapiens 94-97 12126467-1 2002 VPg unlinkase is an unusual eukaryotic enzyme that catalyzes hydrolysis of the phosphodiester bond between residues of the unique tyrosine of VPg (viral protein genome-linked) and the 5;-terminal uridylic acid of picornavirus RNA. Uridine Monophosphate 196-209 tyrosyl-DNA phosphodiesterase 2 Homo sapiens 0-13 11921093-1 2002 Computational analysis predicted three potential hydrophobic transmembrane alpha-helices within the Ura2 multidomain protein of Saccharomyces cerevisiae, the C-terminal subdomain of which catalyses the second step of uridine-monophosphate biosynthesis by its L-aspartate carbamoyltransferase activity (EC 2.1.3.2). Uridine Monophosphate 217-238 bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase Saccharomyces cerevisiae S288C 100-104 11888925-1 2002 AUF1/heterogeneous nuclear ribonucleoprotein D (hnRNPD) binds to adenylate uridylate-rich elements contained in the 3" untranslated region of many short-lived mRNAs. Uridine Monophosphate 75-84 heterogeneous nuclear ribonucleoprotein D Mus musculus 0-46 11888925-1 2002 AUF1/heterogeneous nuclear ribonucleoprotein D (hnRNPD) binds to adenylate uridylate-rich elements contained in the 3" untranslated region of many short-lived mRNAs. Uridine Monophosphate 75-84 heterogeneous nuclear ribonucleoprotein D Mus musculus 48-54 10859327-6 2000 The embryonic lethal abnormal vision (ELAV)-like protein HuR was found to bind with high affinity to the adenylate/uridylate-rich elements of the NOS II 3"-UTR. Uridine Monophosphate 115-124 ELAV like RNA binding protein 1 Homo sapiens 57-60 10878294-6 2000 This metabolite is a potent non-cytotoxic inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo synthesis of uridine monophosphate (UMP). Uridine Monophosphate 145-166 dihydroorotate dehydrogenase (quinone) Homo sapiens 66-94 10878294-6 2000 This metabolite is a potent non-cytotoxic inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo synthesis of uridine monophosphate (UMP). Uridine Monophosphate 145-166 dihydroorotate dehydrogenase (quinone) Homo sapiens 96-101 10878294-6 2000 This metabolite is a potent non-cytotoxic inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo synthesis of uridine monophosphate (UMP). Uridine Monophosphate 168-171 dihydroorotate dehydrogenase (quinone) Homo sapiens 66-94 10878294-6 2000 This metabolite is a potent non-cytotoxic inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo synthesis of uridine monophosphate (UMP). Uridine Monophosphate 168-171 dihydroorotate dehydrogenase (quinone) Homo sapiens 96-101 9582279-8 1998 Substitution of 3"-terminal uridylates by guanine residues abolishes PTRF binding and impairs release activity. Uridine Monophosphate 28-38 caveolae associated 1 Mus musculus 69-73 9602145-7 1998 The URA6 homologue protein produced in Escherichia coli using the glutathione S-transferase gene fusion system was found to catalyze the phosphoryl transfer from ATP to UMP and CMP efficiently and also to AMP and dCMP with lower efficiencies. Uridine Monophosphate 169-172 bifunctional uridylate/adenylate kinase Saccharomyces cerevisiae S288C 4-8 9581837-2 1998 Escherichia coli uracil phosphoribosyltransferase (UPRT) is a pyrimidine salvage enzyme that catalyzes the synthesis of UMP from uracil and 5-phosphoribosyl-alpha-1-diphosphate. Uridine Monophosphate 120-123 uracil phosphoribosyltransferase Mus musculus 51-55 8988631-9 1996 Reassessment of the base specificity of RNase CL1 found that it is guanylic acid, then uridylic acid-preferential, and not poly U preferential. Uridine Monophosphate 87-100 collectin subfamily member 10 Gallus gallus 46-49 8642663-5 1996 Sequence analysis of the ends of these transcripts demonstrated that the 5" termini of both transcripts and the 3" terminus of the full-length product were complementary to the 3" and 5" termini of the vRNA template, respectively, whereas the 3" terminus of the incomplete product corresponded to a sequence located 40 bases downstream from the 5" terminus of the template and was about 20 nucleotides downstream from the uridylate tract, which is the putative signal for polyadenylation. Uridine Monophosphate 422-431 vault RNA 1-1 Homo sapiens 202-206 8852433-1 1996 Dihydroorotate dehydrogenase (EC 1.3.3.1 or EC 1.3.99.11) catalyzes the fourth sequential step in the de novo synthesis of uridine monophosphate. Uridine Monophosphate 123-144 dihydroorotate dehydrogenase Mus musculus 0-28 1618872-9 1992 These data show that the same U3 snoRNA contains different cap structures in different species and suggest that the kind of cap structure that an uridylic acid-rich small nuclear RNA contains is dependent on the RNA polymerase responsible for its synthesis. Uridine Monophosphate 146-159 small nucleolar RNA, C/D box 15A Homo sapiens 33-39 1620106-8 1992 The binding sites for the four proteins were all mapped to a 20-nucleotide U-rich sequence located at the 3" half of the c-fos ARE, which contains no AUUUA pentanucleotides but stretches of uridylate residues. Uridine Monophosphate 190-199 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 121-126 1347664-1 1992 We have previously reported the isolation and characterization of mutant Chinese hamster ovary (CHO-K1) cells of the Urd-A complementation group, which require uridine for growth, are deficient in the activities of the first three enzymes of de novo UMP biosynthesis, and produce markedly reduced amounts of a truncated form of the multifunctional protein CAD, which contains these three enzyme activities. Uridine Monophosphate 250-253 CAD protein Cricetulus griseus 356-359 1776692-6 1991 It is shown with this Western blot assay that although RNase L has been described as a protein of 185-200 kDa under nondenaturating conditions, its 80-kDa (and 40-kDa) component is able to bind 2-5A and to cleave poly(uridylic acid) in a 2-5A-dependent way, independently of other subunit(s) or cofactor(s). Uridine Monophosphate 218-231 ribonuclease L Homo sapiens 55-62 2038055-4 1991 The data are consistent with a model for RF1 selection in which RF1 makes a specific contact(s) to the 3" neighbor and that this interaction is most favorable to uridylic acid. Uridine Monophosphate 162-175 mitochondrial translation release factor 1 Homo sapiens 41-44 2038055-4 1991 The data are consistent with a model for RF1 selection in which RF1 makes a specific contact(s) to the 3" neighbor and that this interaction is most favorable to uridylic acid. Uridine Monophosphate 162-175 mitochondrial translation release factor 1 Homo sapiens 64-67 2189783-1 1990 The FUR1 gene of Saccharomyces cerevisiae encodes uracil phosphoribosyltransferase (UPRTase) which catalyses the conversion of uracil into uridine 5"-monophosphate (UMP) in the pyrimidine salvage pathway. Uridine Monophosphate 139-163 uracil phosphoribosyltransferase Saccharomyces cerevisiae S288C 4-8 2189783-1 1990 The FUR1 gene of Saccharomyces cerevisiae encodes uracil phosphoribosyltransferase (UPRTase) which catalyses the conversion of uracil into uridine 5"-monophosphate (UMP) in the pyrimidine salvage pathway. Uridine Monophosphate 139-163 uracil phosphoribosyltransferase Saccharomyces cerevisiae S288C 50-82 2189783-1 1990 The FUR1 gene of Saccharomyces cerevisiae encodes uracil phosphoribosyltransferase (UPRTase) which catalyses the conversion of uracil into uridine 5"-monophosphate (UMP) in the pyrimidine salvage pathway. Uridine Monophosphate 139-163 uracil phosphoribosyltransferase Saccharomyces cerevisiae S288C 84-91