PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20823602-0	2010	Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors.	4-hydroxybenzaldehyde	53-74	butyrylcholinesterase	Homo sapiens	96-110
20833259-7	2010	Kvbeta2 was found to catalyse the reduction of aromatic aldehyde substrates such as 2, 3 and 4-nitrobenzaldehydes, 4-hydroxybenzaldehyde, pyridine 2-aldehyde and benzaldehyde.	4-hydroxybenzaldehyde	115-136	potassium voltage-gated channel subfamily A regulatory beta subunit 2	Homo sapiens	0-7
20823602-1	2010	A series of difunctionalized 4-hydroxybenzaldehyde derivatives were designed, synthesized and evaluated as cholinesterase (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)) inhibitors.	4-hydroxybenzaldehyde	29-50	butyrylcholinesterase	Homo sapiens	107-121
20823602-1	2010	A series of difunctionalized 4-hydroxybenzaldehyde derivatives were designed, synthesized and evaluated as cholinesterase (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)) inhibitors.	4-hydroxybenzaldehyde	29-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	123-143
20823602-1	2010	A series of difunctionalized 4-hydroxybenzaldehyde derivatives were designed, synthesized and evaluated as cholinesterase (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)) inhibitors.	4-hydroxybenzaldehyde	29-50	acetylcholinesterase (Cartwright blood group)	Homo sapiens	145-149
20823602-1	2010	A series of difunctionalized 4-hydroxybenzaldehyde derivatives were designed, synthesized and evaluated as cholinesterase (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)) inhibitors.	4-hydroxybenzaldehyde	29-50	butyrylcholinesterase	Homo sapiens	178-182
20452769-1	2010	A series of novel cholinesterase inhibitors, being composed of 4-[(diethylamino)methyl]-phenoxy and secondary amine which were linked with a different length alkyl chain, were designed and synthesized from the starting material p-hydroxybenzaldehyde.	4-hydroxybenzaldehyde	228-249	acetylcholinesterase (Cartwright blood group)	Homo sapiens	18-32
19138517-1	2009	Previously it was found that 4-hydroxybenzaldehyde is a competitive inhibitor of GABA transaminase.	4-hydroxybenzaldehyde	29-50	4-aminobutyrate aminotransferase	Homo sapiens	81-98
29555206-7	2018	Hippuric and protocatechuic acids inhibited P-selectin expression, ferulic acid reduced platelet-monocyte aggregation, while 4-hydroxybenzaldehyde affected P-selectin expression, platelet-neutrophil and monocyte aggregation.	4-hydroxybenzaldehyde	125-146	selectin P	Homo sapiens	156-166
16690313-1	2006	Previous study showed that 4-hydroxybenzaldehyde is a competitive inhibitor of GABA transaminase.	4-hydroxybenzaldehyde	27-48	4-aminobutyrate aminotransferase	Homo sapiens	79-96
16290145-1	2006	4-Hydroxybenzaldehyde (HBA) derivatives were examined as inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH).	4-hydroxybenzaldehyde	0-21	4-aminobutyrate aminotransferase	Homo sapiens	72-89
16290145-1	2006	4-Hydroxybenzaldehyde (HBA) derivatives were examined as inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH).	4-hydroxybenzaldehyde	0-21	4-aminobutyrate aminotransferase	Homo sapiens	91-97
16290145-1	2006	4-Hydroxybenzaldehyde (HBA) derivatives were examined as inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH).	4-hydroxybenzaldehyde	0-21	aldehyde dehydrogenase 5 family member A1	Homo sapiens	103-138
16290145-1	2006	4-Hydroxybenzaldehyde (HBA) derivatives were examined as inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH).	4-hydroxybenzaldehyde	0-21	aldehyde dehydrogenase 5 family member A1	Homo sapiens	140-145
16290145-1	2006	4-Hydroxybenzaldehyde (HBA) derivatives were examined as inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH).	4-hydroxybenzaldehyde	23-26	4-aminobutyrate aminotransferase	Homo sapiens	72-89
16290145-1	2006	4-Hydroxybenzaldehyde (HBA) derivatives were examined as inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH).	4-hydroxybenzaldehyde	23-26	4-aminobutyrate aminotransferase	Homo sapiens	91-97
16290145-1	2006	4-Hydroxybenzaldehyde (HBA) derivatives were examined as inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH).	4-hydroxybenzaldehyde	23-26	aldehyde dehydrogenase 5 family member A1	Homo sapiens	103-138
16290145-1	2006	4-Hydroxybenzaldehyde (HBA) derivatives were examined as inhibitors for GABA transaminase (GABA-T) and succinic semialdehyde dehydrogenase (SSADH).	4-hydroxybenzaldehyde	23-26	aldehyde dehydrogenase 5 family member A1	Homo sapiens	140-145
16174805-6	2005	In vitro studies also revealed that bioactivation of p-cresol was mediated by multiple cytochromes P450, but CYP2D6, 2E1, and 1A2 are the most active enzymes for formation of quinone methide, 4-methyl-ortho-benzoquinone, and 4-hydroxybenzaldehyde, respectively.	4-hydroxybenzaldehyde	225-246	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	109-115
32145722-0	2020	4-Hydroxybenzaldehyde Restricts the Intracellular Growth of Toxoplasma gondii by Inducing SIRT1-Mediated Autophagy in Macrophages.	4-hydroxybenzaldehyde	0-21	sirtuin 1	Mus musculus	90-95
32145722-3	2020	In this study, we found that 4-hydroxybenzaldehyde (4- HBA) induced autophagy and the expression of NAD-dependent protein deacetylase sirtuin-1 (SIRT1) in primary murine bone marrow-derived macrophages (BMDMs).	4-hydroxybenzaldehyde	29-50	sirtuin 1	Mus musculus	100-143
32145722-3	2020	In this study, we found that 4-hydroxybenzaldehyde (4- HBA) induced autophagy and the expression of NAD-dependent protein deacetylase sirtuin-1 (SIRT1) in primary murine bone marrow-derived macrophages (BMDMs).	4-hydroxybenzaldehyde	29-50	sirtuin 1	Mus musculus	145-150
31153120-2	2019	By effectively integrating isophorone and phosphate group via p-hydroxybenzaldehyde, the alkaline phosphatase (ALP) detection probe was obtained.	4-hydroxybenzaldehyde	62-83	alkaline phosphatase, placental	Homo sapiens	89-109
31153120-2	2019	By effectively integrating isophorone and phosphate group via p-hydroxybenzaldehyde, the alkaline phosphatase (ALP) detection probe was obtained.	4-hydroxybenzaldehyde	62-83	alkaline phosphatase, placental	Homo sapiens	111-114
11025174-4	2000	4-Hydroxybenzaldehyde, an analogue of p-hydroxybenzyl alcohol, showed an inhibitory effect on the GABA transaminase, and its inhibitory activity was higher than that of valproic acid, a known anticonvulsant.	4-hydroxybenzaldehyde	0-21	4-aminobutyrate aminotransferase	Rattus norvegicus	98-115
10813903-0	2000	NBS-Promoted reactions of symmetrically hindered methylphenols via p-benzoquinone methide Symmetrically hindered methylphenols 1 react smoothly with NBS to form transient intermediates, p-benzoquinone methides (BM), which can be further processed to give hydroxybenzaldehydes in the presence of DMSO.	4-hydroxybenzaldehyde	255-275	nibrin	Homo sapiens	0-3
10813903-0	2000	NBS-Promoted reactions of symmetrically hindered methylphenols via p-benzoquinone methide Symmetrically hindered methylphenols 1 react smoothly with NBS to form transient intermediates, p-benzoquinone methides (BM), which can be further processed to give hydroxybenzaldehydes in the presence of DMSO.	4-hydroxybenzaldehyde	255-275	nibrin	Homo sapiens	149-152
10052588-3	1998	Enzyme modification of glycans was demonstrated by separation of the products of hydrolysis of lactose hydrazone with beta-galactosidase, using hydroxybenzaldehyde-derivatized polystyrene beads.	4-hydroxybenzaldehyde	144-163	galactosidase beta 1	Homo sapiens	118-136
1295894-5	1992	The structural comparison of 4-hydroxybenzaldehyde and ascorbate suggests that the hydroxy group at C-5, carbonyl group at C-1 and lactone ring of ascorbate are important for the binding to the enzyme.	4-hydroxybenzaldehyde	29-50	complement C5	Sus scrofa	100-103
16348226-9	1990	GS-15 oxidized potential aromatic intermediates in the oxidation of toluene (benzylalcohol and benzaldehyde) and p-cresol (p-hydroxybenzylalcohol and p-hydroxybenzaldehyde).	4-hydroxybenzaldehyde	150-171	Bet1 golgi vesicular membrane trafficking protein like	Homo sapiens	0-5
35421787-10	2022	Thus, the results indicated that 4HB exerted its vasodilatory effect via cGMP and beta2 pathways, M3-dependent PLC/IP3 pathways, and potassium and calcium channels.	4-hydroxybenzaldehyde	33-36	UDP glucuronosyltransferase 1 family, polypeptide A7C	Rattus norvegicus	82-87
6452931-4	1981	4-hydroxybenzaldehyde, a potent SSADH inhibitor did not increase GABA level at a dosage which induces a 99% inhibition of SSADH.	4-hydroxybenzaldehyde	0-21	aldehyde dehydrogenase 5 family member A1	Homo sapiens	32-37
32996541-3	2020	In this study, a novel pH-responsive worm-like micelle system was constructed by mixing cetyltrimethylammonium bromide (CTAB), 4-hydroxybenzaldehyde (HB) and p-toluidine (MB) at the molar ratio of 60 mM : 40 mM : 40 mM.	4-hydroxybenzaldehyde	127-148	phenylalanine hydroxylase	Homo sapiens	23-25
32996541-3	2020	In this study, a novel pH-responsive worm-like micelle system was constructed by mixing cetyltrimethylammonium bromide (CTAB), 4-hydroxybenzaldehyde (HB) and p-toluidine (MB) at the molar ratio of 60 mM : 40 mM : 40 mM.	4-hydroxybenzaldehyde	150-152	phenylalanine hydroxylase	Homo sapiens	23-25
29079748-4	2017	Using an in vitro approach, we found that 4-HBA significantly promoted keratinocyte cell migration and invasion by increasing focal adhesion kinase and Src activity.	4-hydroxybenzaldehyde	42-47	Rous sarcoma oncogene	Mus musculus	152-155
29079748-7	2017	Taken together, our results demonstrated that treatment with 4-HBA promoted keratinocyte migration and wound healing in mouse skin through the Src/mitogen-activated protein kinase pathway.	4-hydroxybenzaldehyde	61-66	Rous sarcoma oncogene	Mus musculus	143-146
27693056-4	2016	Here, we provide key insights into this long-standing biosynthetic problem by uncovering molecular details of the first and last reactions of the pathway in the yeast Saccharomyces cerevisiae, namely the deamination of tyrosine to 4-hydroxyphenylpyruvate by Aro8 and Aro9, and the oxidation of 4-hydroxybenzaldehyde to 4-HB by Hfd1.	4-hydroxybenzaldehyde	294-315	bifunctional 2-aminoadipate transaminase/aromatic-amino-acid:2-oxoglutarate transaminase	Saccharomyces cerevisiae S288C	258-262
27693056-4	2016	Here, we provide key insights into this long-standing biosynthetic problem by uncovering molecular details of the first and last reactions of the pathway in the yeast Saccharomyces cerevisiae, namely the deamination of tyrosine to 4-hydroxyphenylpyruvate by Aro8 and Aro9, and the oxidation of 4-hydroxybenzaldehyde to 4-HB by Hfd1.	4-hydroxybenzaldehyde	294-315	aromatic-amino-acid:2-oxoglutarate transaminase	Saccharomyces cerevisiae S288C	267-271
27693056-4	2016	Here, we provide key insights into this long-standing biosynthetic problem by uncovering molecular details of the first and last reactions of the pathway in the yeast Saccharomyces cerevisiae, namely the deamination of tyrosine to 4-hydroxyphenylpyruvate by Aro8 and Aro9, and the oxidation of 4-hydroxybenzaldehyde to 4-HB by Hfd1.	4-hydroxybenzaldehyde	294-315	hexadecenal dehydrogenase	Saccharomyces cerevisiae S288C	327-331
27405172-10	2016	In the same time we found out p-hydroxybenzaldehyde (molecular weight: 122.036 7) and 2,3,5-trihydroxybenzaldehyde-2-O-glycoside (molecular weight: 316.079 4) were the main degradation products of THSG in tap water and water containing Cu2+, Ca2+, Zn2+, Mg2+ and Al3+.	4-hydroxybenzaldehyde	30-51	filamin B	Homo sapiens	205-208