PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
7350912-3	1980	Purified carboxyl ester hydrolase (carboxylic-ester hydrolase, EC 3.1.1.1) from human pancreatic juice was found to hydrolyze triacetin, methyl butyrate and glycerides solubilized by bile salts.	Triacetin	126-135	carboxyl ester lipase	Homo sapiens	9-33
33662568-10	2021	The 2-arachidonoylglycerol (2-AG), nicosulfuron, and triacetin exhibited a higher binding affinity to the zebrafish BChE-like protein than BCh and ACh.	Triacetin	53-62	acetylcholinesterase	Danio rerio	147-150
623100-1	1978	Esterase D (EsD), purified from human erythrocytes and tested with a variety of substrates, hydrolyzed only triacetin, tributyrin, and certain soluble aryl esters of aliphatic acids.	Triacetin	108-117	esterase D	Homo sapiens	0-10
623100-1	1978	Esterase D (EsD), purified from human erythrocytes and tested with a variety of substrates, hydrolyzed only triacetin, tributyrin, and certain soluble aryl esters of aliphatic acids.	Triacetin	108-117	esterase D	Homo sapiens	12-15
990257-10	1976	Hydrolysis by pancreatic lipase of dissolved monomeric p-nitrophenyl acetate and triacetin is considerably enhanced (100- to 500-fold) by various interfaces.	Triacetin	81-90	pancreatic lipase	Homo sapiens	14-31
29174530-8	2018	These changes were also observed in rats fed daily for 3 weeks with glyceryl triacetate, though unlike B-GOS , cortical histone deacetylase (HDAC1, HDAC2) mRNAs were also increased which suggested an additional epigenetic action of direct acetate supplementation.	Triacetin	68-87	histone deacetylase 1	Rattus norvegicus	141-146
30606543-5	2019	The immobilized PPL (PPL-IL-CS-Fe3O4) exhibited 1.93-fold higher specific activity than PPL-CS-Fe3O4 when triacetin was used as the substrate, and showed 95 mg/g of lipase immobilization capacity and 382% of activity recovery.	Triacetin	106-115	periplakin	Homo sapiens	16-19
30606543-5	2019	The immobilized PPL (PPL-IL-CS-Fe3O4) exhibited 1.93-fold higher specific activity than PPL-CS-Fe3O4 when triacetin was used as the substrate, and showed 95 mg/g of lipase immobilization capacity and 382% of activity recovery.	Triacetin	106-115	periplakin	Homo sapiens	21-36
30606543-5	2019	The immobilized PPL (PPL-IL-CS-Fe3O4) exhibited 1.93-fold higher specific activity than PPL-CS-Fe3O4 when triacetin was used as the substrate, and showed 95 mg/g of lipase immobilization capacity and 382% of activity recovery.	Triacetin	106-115	periplakin	Homo sapiens	21-24
29174530-8	2018	These changes were also observed in rats fed daily for 3 weeks with glyceryl triacetate, though unlike B-GOS , cortical histone deacetylase (HDAC1, HDAC2) mRNAs were also increased which suggested an additional epigenetic action of direct acetate supplementation.	Triacetin	68-87	histone deacetylase 2	Rattus norvegicus	148-153
28985603-2	2017	The supports were used to immobilize Candida antarctic lipase B (CALB) and the influence of different functional groups of ionic liquids on enzymatic properties was investigated by the hydrolysis reaction of triacetin.	Triacetin	208-217	calbindin 1	Homo sapiens	37-63
29203794-7	2017	Next, we found that deletion of SHATI/NAT8L induces several behavioral deficits in mice, and that glyceryltriacetate (GTA) treatment ameliorates the behavioral impairments and normalizes the reduced protein level of MBP in juvenile Shati -/- mice.	Triacetin	98-116	myelin basic protein	Mus musculus	216-219
29203794-7	2017	Next, we found that deletion of SHATI/NAT8L induces several behavioral deficits in mice, and that glyceryltriacetate (GTA) treatment ameliorates the behavioral impairments and normalizes the reduced protein level of MBP in juvenile Shati -/- mice.	Triacetin	98-116	N-acetyltransferase 8-like	Mus musculus	232-237
29203794-7	2017	Next, we found that deletion of SHATI/NAT8L induces several behavioral deficits in mice, and that glyceryltriacetate (GTA) treatment ameliorates the behavioral impairments and normalizes the reduced protein level of MBP in juvenile Shati -/- mice.	Triacetin	118-121	myelin basic protein	Mus musculus	216-219
29203794-7	2017	Next, we found that deletion of SHATI/NAT8L induces several behavioral deficits in mice, and that glyceryltriacetate (GTA) treatment ameliorates the behavioral impairments and normalizes the reduced protein level of MBP in juvenile Shati -/- mice.	Triacetin	118-121	N-acetyltransferase 8-like	Mus musculus	232-237
28985603-2	2017	The supports were used to immobilize Candida antarctic lipase B (CALB) and the influence of different functional groups of ionic liquids on enzymatic properties was investigated by the hydrolysis reaction of triacetin.	Triacetin	208-217	calbindin 1	Homo sapiens	65-69
25573156-6	2015	The FDA approved food additive Triacetin (glyceryl triacetate, GTA) has been safely used for acetate supplementation therapy in Canavan disease, a leukodystrophy due to ASPA mutation.	Triacetin	31-40	aspartoacylase	Homo sapiens	169-173
25573156-6	2015	The FDA approved food additive Triacetin (glyceryl triacetate, GTA) has been safely used for acetate supplementation therapy in Canavan disease, a leukodystrophy due to ASPA mutation.	Triacetin	42-61	aspartoacylase	Homo sapiens	169-173
21272004-7	2011	Immunohistochemical and morphological analysis demonstrated that a daily treatment with GTA significantly reduced the percentage of reactive glial fibrillary acidic protein-positive astrocytes and activated CD11b-positive microglia by 40-50% in rats subjected to LPS-induced neuroinflammation.	Triacetin	88-91	integrin subunit alpha M	Rattus norvegicus	207-212
24898794-8	2014	CD73 activity in these rats was increased by 46% with the 28-day GTA treatment compared to the water-treated rats.	Triacetin	65-68	5' nucleotidase, ecto	Rattus norvegicus	0-4
24898794-10	2014	Interventional GTA therapy, beginning on day 14 following the induction of neuroinflammation, resulted in a 67% increase in CD73 levels and a 155% increase in adenosine A2A receptor levels.	Triacetin	15-18	5' nucleotidase, ecto	Rattus norvegicus	124-128
24898794-10	2014	Interventional GTA therapy, beginning on day 14 following the induction of neuroinflammation, resulted in a 67% increase in CD73 levels and a 155% increase in adenosine A2A receptor levels.	Triacetin	15-18	adenosine A2a receptor	Rattus norvegicus	159-181
23996800-3	2014	This preclinical study sought to test the efficacy of the food additive Triacetin (glyceryl triacetate, GTA) as a novel therapy to increase acetate bioavailability in glioma cells.	Triacetin	72-81	integrin subunit alpha 2b	Homo sapiens	104-107
24278309-3	2013	The short chain triglyceride glyceryl triacetate (GTA), which increases histone acetylation and inhibits histone deacetylase expression, has been safely used for acetate supplementation in Canavan disease, a leukodystrophy due to ASPA mutation.	Triacetin	29-48	aspartoacylase	Homo sapiens	230-234
24278309-3	2013	The short chain triglyceride glyceryl triacetate (GTA), which increases histone acetylation and inhibits histone deacetylase expression, has been safely used for acetate supplementation in Canavan disease, a leukodystrophy due to ASPA mutation.	Triacetin	50-53	aspartoacylase	Homo sapiens	230-234
24898794-3	2014	METHODS: To test this hypothesis, we quantified the ability of GTA to alter brain levels of ecto-5"-nucleotidase (CD73), adenosine kinase (AK), and adenosine A2A receptor using western blot analysis and CD73 activity by measuring the rate of AMP hydrolysis.	Triacetin	63-66	5' nucleotidase, ecto	Rattus norvegicus	92-112
24898794-3	2014	METHODS: To test this hypothesis, we quantified the ability of GTA to alter brain levels of ecto-5"-nucleotidase (CD73), adenosine kinase (AK), and adenosine A2A receptor using western blot analysis and CD73 activity by measuring the rate of AMP hydrolysis.	Triacetin	63-66	5' nucleotidase, ecto	Rattus norvegicus	114-118
24898794-3	2014	METHODS: To test this hypothesis, we quantified the ability of GTA to alter brain levels of ecto-5"-nucleotidase (CD73), adenosine kinase (AK), and adenosine A2A receptor using western blot analysis and CD73 activity by measuring the rate of AMP hydrolysis.	Triacetin	63-66	adenosine kinase	Rattus norvegicus	121-137
24898794-3	2014	METHODS: To test this hypothesis, we quantified the ability of GTA to alter brain levels of ecto-5"-nucleotidase (CD73), adenosine kinase (AK), and adenosine A2A receptor using western blot analysis and CD73 activity by measuring the rate of AMP hydrolysis.	Triacetin	63-66	adenosine A2a receptor	Rattus norvegicus	148-170
24898794-3	2014	METHODS: To test this hypothesis, we quantified the ability of GTA to alter brain levels of ecto-5"-nucleotidase (CD73), adenosine kinase (AK), and adenosine A2A receptor using western blot analysis and CD73 activity by measuring the rate of AMP hydrolysis.	Triacetin	63-66	5' nucleotidase, ecto	Rattus norvegicus	203-207
23099248-5	2013	Propylene carbonate and triacetin act by locating at the PEO-PPO interface and increasing its hydrophobicity.	Triacetin	24-33	protoporphyrinogen oxidase	Homo sapiens	61-64
22413888-2	2012	Additionally, a single dose of glyceryl triacetate, used to induce acetate supplementation, increases histone H3 and H4 acetylation and inhibits histone deacetylase activity and histone deacetylase-2 expression in normal rat brain.	Triacetin	31-50	histone deacetylase 2	Rattus norvegicus	178-199
22413888-4	2012	METHODS: In this study, we examined the effect of a 28-day-dosing regimen of glyceryl triacetate, to induce acetate supplementation, on brain histone acetylation and interleukin-1beta expression in a rat model of lipopolysaccharide-induced neuroinflammation.	Triacetin	77-96	interleukin 1 beta	Rattus norvegicus	166-183
21272004-8	2011	Further, in rats subjected to neuroinflammation, GTA significantly increased the number of choline acetyltransferase (ChAT)-positive cells by 40% in the basal forebrain compared to untreated controls.	Triacetin	49-52	choline O-acetyltransferase	Rattus norvegicus	91-116
20542423-4	2010	It was found that by using the immobilized lipase from Candida antarctica yields as high as 80% of both fatty acid esters and triacetin could be achieved.	Triacetin	126-135	PAN0_003d1715	Moesziomyces antarcticus	43-49
15359580-4	2004	An excess of triacetin was added to the emulsion so that water could be extracted into the continuous phase, allowing the insulin-loaded microsphere precipitation.	Triacetin	13-22	insulin	Homo sapiens	122-129
18267138-7	2008	The specific activities of lipase B for the hydrolysis of tributyrin and triacetin were determined as 16+/-2 U mg(-1) and 2+/-0.2 U mg(-1) (per mg commercial lipase preparation), respectively.	Triacetin	73-82	PAN0_003d1715	Moesziomyces antarcticus	27-33
18267138-7	2008	The specific activities of lipase B for the hydrolysis of tributyrin and triacetin were determined as 16+/-2 U mg(-1) and 2+/-0.2 U mg(-1) (per mg commercial lipase preparation), respectively.	Triacetin	73-82	PAN0_003d1715	Moesziomyces antarcticus	158-164
16724578-11	2006	Therefore, the new formulation of CsA using triacetin appears to have an advantage over the commercial soft capsules of CsA using a volatile cosolvent such as ethanol.	Triacetin	44-53	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	34-37
1366804-3	1990	The lipase immobilized on EP-400 polyethylene was found to be effective in transesterification using tributyrin or triacetin as acyl donors with l-menthol as acceptor.	Triacetin	115-124	E1A binding protein p400	Homo sapiens	26-32
8471055-4	1993	The results showed that the recombinant cholesterol esterase displayed both lipolytic and lipoamidase activities and was capable of hydrolysing triacetin and lipoyl-4-aminobenzoate (LPAB).	Triacetin	144-153	carboxyl ester lipase	Homo sapiens	40-60