PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 8973550-1 1996 On intravenous injection to rats, decasaccharides gave rise to a short-lived peak of lipoprotein lipase (LPL) activity, whereas octa- and hexasaccharides caused only marginal increases. decasaccharides 34-49 lipoprotein lipase Rattus norvegicus 85-103 16120610-7 2005 In contrast, high affinity interactions with PTN required decasaccharides with E units (GlcUAbeta1-3GalNAc(4, 6-O-disulfate)), B units (GlcUA(2-O-sulfate)beta1-3GalNAc(4-O-sulfate)), and/or their IdoUA-containing counterparts (iE and iB) in addition to D/iD units, although the biological significance of such strong interactions remains to be investigated. decasaccharides 58-73 pleiotrophin Sus scrofa 45-48 12000311-4 2002 From decasaccharides and longer, the k(ass) and affinity for FGF-2 was reduced substantially (tetradecasaccharide k(ass) 470000 M(-1) x s(-1), K(d) 30 nM). decasaccharides 5-20 fibroblast growth factor 2 Rattus norvegicus 61-66 11799124-8 2002 At restricted concentrations of oligosaccharides (4 ng/ml), HGF/SF required decasaccharides, whereas at higher concentrations (100 ng/ml) even tetrasaccharides were able to partly restore DNA synthesis. decasaccharides 76-91 hepatocyte growth factor Homo sapiens 60-66 8973550-1 1996 On intravenous injection to rats, decasaccharides gave rise to a short-lived peak of lipoprotein lipase (LPL) activity, whereas octa- and hexasaccharides caused only marginal increases. decasaccharides 34-49 lipoprotein lipase Rattus norvegicus 105-108 8973550-2 1996 In isolated hearts perfused by a single pass, decasaccharides released LPL more efficiently than conventional heparin on a mass basis. decasaccharides 46-61 lipoprotein lipase Rattus norvegicus 71-74 8973550-12 1996 Thus injection of decasaccharides leads to accelerated turnover of LPL with loss of functional LPL from extrahepatic tissues. decasaccharides 18-33 lipoprotein lipase Rattus norvegicus 67-70 8973550-12 1996 Thus injection of decasaccharides leads to accelerated turnover of LPL with loss of functional LPL from extrahepatic tissues. decasaccharides 18-33 lipoprotein lipase Rattus norvegicus 95-98 7585697-7 1995 For oligosaccharides larger than decasaccharides, a small basic protein, angiogenin (M(r) = 14,120), was used to form the complex (an inhomogeneous hexadecasaccharide fraction was the largest available for this study). decasaccharides 33-48 angiogenin Homo sapiens 73-83 8810923-2 1996 The results show that heparin decasaccharides form a 1:1 complex with dimeric LPL and that decasaccharides are the shortest heparin fragments which can completely satisfy the heparin binding regions in dimeric LPL. decasaccharides 30-45 lipoprotein lipase Homo sapiens 78-81 8810923-2 1996 The results show that heparin decasaccharides form a 1:1 complex with dimeric LPL and that decasaccharides are the shortest heparin fragments which can completely satisfy the heparin binding regions in dimeric LPL. decasaccharides 30-45 lipoprotein lipase Homo sapiens 210-213 8810923-7 1996 The number of ionic interactions between LPL and high-affinity decasaccharides was estimated to be 10. decasaccharides 63-78 lipoprotein lipase Homo sapiens 41-44 21913222-6 2012 HAS2 mRNA expression was altered after the treatment with both tetrasaccharides and decasaccharides. decasaccharides 84-99 hyaluronan synthase 2 Homo sapiens 0-4 6940150-2 1981 Direct measurements of the kinetic behavior of the hexasaccharides, octasaccharides, and decasaccharides showed that these fractions greatly enhanced the rate of Factor Xa inactivation by antithrombin. decasaccharides 89-104 coagulation factor X Homo sapiens 162-171 6940150-2 1981 Direct measurements of the kinetic behavior of the hexasaccharides, octasaccharides, and decasaccharides showed that these fractions greatly enhanced the rate of Factor Xa inactivation by antithrombin. decasaccharides 89-104 serpin family C member 1 Homo sapiens 188-200 6940150-5 1981 The avidity of the hexasaccharides, octasaccharides, and decasaccharides for the protease inhibitor increased as a function of size with the respective dissociation constants ranging from 5.5 X 10(-6) M to 2.9 X 10(-7) M. These data suggest that the region of the heparin molecule needed for catalyzing Factor Xa-antithrombin interaction is intimately related to the antithrombin binding domain. decasaccharides 57-72 coagulation factor X Homo sapiens 303-312 6940150-5 1981 The avidity of the hexasaccharides, octasaccharides, and decasaccharides for the protease inhibitor increased as a function of size with the respective dissociation constants ranging from 5.5 X 10(-6) M to 2.9 X 10(-7) M. These data suggest that the region of the heparin molecule needed for catalyzing Factor Xa-antithrombin interaction is intimately related to the antithrombin binding domain. decasaccharides 57-72 serpin family C member 1 Homo sapiens 313-325 6940150-5 1981 The avidity of the hexasaccharides, octasaccharides, and decasaccharides for the protease inhibitor increased as a function of size with the respective dissociation constants ranging from 5.5 X 10(-6) M to 2.9 X 10(-7) M. These data suggest that the region of the heparin molecule needed for catalyzing Factor Xa-antithrombin interaction is intimately related to the antithrombin binding domain. decasaccharides 57-72 serpin family C member 1 Homo sapiens 367-379 32348723-3 2020 This work uses native mass spectrometry to investigate PF4 interactions with relatively short heparin chains (up to decasaccharides). decasaccharides 116-131 platelet factor 4 Homo sapiens 55-58 30205243-4 2018 BMP-2 could bind to heparin hexasaccharides (dp6) and octasaccharides (dp8), but decasaccharides (dp10) were the minimum chain length required for both efficient binding of BMP-2 and consequent heparin-dependent cell responses. decasaccharides 81-96 bone morphogenetic protein 2 Homo sapiens 173-178 21913222-7 2012 Phosphorylation of Akt was suppressed after 1 h treatment with HA decasaccharides, and the effect was partially reversed by anti-CD44 monoclonal antibody. decasaccharides 66-81 AKT serine/threonine kinase 1 Homo sapiens 19-22 21913222-7 2012 Phosphorylation of Akt was suppressed after 1 h treatment with HA decasaccharides, and the effect was partially reversed by anti-CD44 monoclonal antibody. decasaccharides 66-81 CD44 molecule (Indian blood group) Homo sapiens 129-133 17317686-7 2007 Further fractionation of decasaccharides by anion-exchange chromatography revealed that most of the decasaccharides had HGF-inducing activity and the extent of sulfation was roughly related to the activity. decasaccharides 25-40 hepatocyte growth factor Homo sapiens 120-123 17317686-7 2007 Further fractionation of decasaccharides by anion-exchange chromatography revealed that most of the decasaccharides had HGF-inducing activity and the extent of sulfation was roughly related to the activity. decasaccharides 100-115 hepatocyte growth factor Homo sapiens 120-123 16624894-10 2006 Decasaccharides and dodecasaccharides containing one or two GalNAc4,6SO3 residues stimulated thrombin inhibition by HCII and prolonged the clotting time of normal but not HCII-depleted human plasma. decasaccharides 0-15 coagulation factor II, thrombin Homo sapiens 93-101 16624894-10 2006 Decasaccharides and dodecasaccharides containing one or two GalNAc4,6SO3 residues stimulated thrombin inhibition by HCII and prolonged the clotting time of normal but not HCII-depleted human plasma. decasaccharides 0-15 serpin family D member 1 Homo sapiens 116-120