PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2476547-5 1989 The greatest increases in punished responding were produced by the buspirone analogs BMY 7378 and ipsapirone, which act at the 5-HT1A receptor. ipsapirone 98-108 5-hydroxytryptamine receptor 1A Homo sapiens 127-142 2524677-4 1989 In contrast, the selective 5-HT1A agonists 8-OH-DPAT (8-hydroxy-2-[di-n-propylamino]tetralin) and ipsapirone (2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3 -(2H) one-1,1-dioxidehydrochloride) did not increase levels of prolactin in plasma at any dose. ipsapirone 98-108 5-hydroxytryptamine receptor 1A Rattus norvegicus 27-33 2565390-0 1989 Effect of gepirone and ipsapirone on the stimulated and unstimulated secretion of prolactin in the rat. ipsapirone 23-33 prolactin Rattus norvegicus 82-91 2623035-5 1989 The administration of the 5-HT1A agonist, ipsapirone (2.5, 5 and 10 mg/kg) resulted in a facilitation of the sexual behaviour expressed as a reduction in the number of intromissions preceding ejaculation accompanied by a shortening of the ejaculation latency. ipsapirone 42-52 5-hydroxytryptamine receptor 1A Rattus norvegicus 26-32 2623048-0 1989 In vivo interactions of NAN-190, a putative selective 5-HT1A antagonist, with ipsapirone. ipsapirone 78-88 5-hydroxytryptamine receptor 1A Rattus norvegicus 54-60 2623048-2 1989 The selective 5-HT1A agent ipsapirone suppressed operant responding, but this effect was not antagonised by NAN-190, which suppressed responding itself in a dose-related manner, and had additive effects when administered with ipsapirone. ipsapirone 27-37 5-hydroxytryptamine receptor 1A Rattus norvegicus 14-20 2501811-6 1989 Additionally, d,l-propranolol was used as a 5HT-1 antagonist and was found to block the behavioral effects of the 5HT-1A agonists ipsapirone and buspirone without having significant effects by itself. ipsapirone 130-140 5-hydroxytryptamine receptor 1A Rattus norvegicus 114-120 2526950-2 1989 The 8-OHDPAT cue was mimicked by the 5-HT1A agonists ipsapirone, buspirone, gepirone and partially by 5-methoxy-N,N-dimethyltryptamine and d-LSD. ipsapirone 53-63 5-hydroxytryptamine receptor 1A Rattus norvegicus 37-43 11175385-0 1989 Tolerance to the behavioural effects of the selective 5-HT(1A) agent, ipsapirone. ipsapirone 70-80 5-hydroxytryptamine receptor 1A Rattus norvegicus 54-61 2748869-9 1989 Single injections of 5-HT1A agonists (8-OH-DPAT, buspirone, ipsapirone, gepirone) but not of benzodiazepine anxiolytics have similar effects. ipsapirone 60-70 5-hydroxytryptamine receptor 1A Rattus norvegicus 21-27 2479937-1 1989 Ipsapirone (TVX Q 7821), a compound with a high affinity for the 5-HT1A receptor-subtype, decreased by itself 5-HIAA level and reduced 5-HIAA accumulation after probenecid administration in the rat hypothalamus. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 65-71 2887435-6 1987 The similar stimulus properties of 8-OHDPAT and the novel anxiolytics (buspirone, ipsapirone) are mirrored by the common abilities of these agents to selectively inhibit 5-HT1A binding and release punished responding. ipsapirone 82-92 5-hydroxytryptamine receptor 1A Homo sapiens 170-176 2567039-3 1989 The selective 5-hydroxytryptamine-1A (5-HT1A) anxiolytics buspirone, gepirone, ipsapirone, and SM-3997 have several important new and unique features that will be reviewed in this paper. ipsapirone 79-89 5-hydroxytryptamine receptor 1A Homo sapiens 14-36 2567039-3 1989 The selective 5-hydroxytryptamine-1A (5-HT1A) anxiolytics buspirone, gepirone, ipsapirone, and SM-3997 have several important new and unique features that will be reviewed in this paper. ipsapirone 79-89 5-hydroxytryptamine receptor 1A Homo sapiens 38-44 2975225-4 1988 The non-benzodiazepine anxiolytics buspirone (1.25-5.0 mg/kg), gepirone (3.0-10.0 mg/kg) and the related 5-HT1A ligand ipsapirone (1.0-10.0 mg/kg) blocked potentiated startle, though effects of the non-selective serotonin antagonist methysergide (0.3-10.0 mg/kg) fell short of significance. ipsapirone 119-129 5-hydroxytryptamine receptor 1A Rattus norvegicus 105-111 2895033-15 1988 Ipsapirone, a 5-HT1A-active drug purported both as an agonist and as an antagonist, inhibited MK-771-evoked WDS, like 8-OH-DPAT, but did not induce the serotonin syndrome, unlike 8-OH-DPAT. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 14-20 2901381-7 1988 Buspirone is clinically active in the treatment of anxiety and it, and other anxiolytic candidates, gepirone and isapirone, may act as agonists (or perhaps partial agonists) on 5HT1A receptors. ipsapirone 113-122 5-hydroxytryptamine receptor 1A Homo sapiens 177-182 2849052-5 1988 Two selective 5-HT1A agonists: 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) and ipsapirone, could not stimulate adenylate cyclase. ipsapirone 87-97 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 14-20 2901112-6 1988 (-)-Pindolol, a potent 5-HT1A antagonist, prevented gepirone- and ipsapirone-induced hypothermia and corticosterone secretion. ipsapirone 66-76 5-hydroxytryptamine receptor 1A Rattus norvegicus 23-29 2901112-9 1988 It is concluded that buspirone, gepirone and ipsapirone produce hypothermia and increase plasma concentrations of corticosterone by activating 5-HT1A receptor mechanisms. ipsapirone 45-55 5-hydroxytryptamine receptor 1A Rattus norvegicus 143-149 2961850-6 1988 Of special interest was the observation that 5-HT1A agonists such as serotonin, 8-OH-DPAT, and ipsapirone competed with equal high affinities for [3H]spiroxatrine or [3H]8-OH-DPAT-labelled 5-HT1A receptors. ipsapirone 95-105 5-hydroxytryptamine receptor 1A Rattus norvegicus 45-51 2961850-6 1988 Of special interest was the observation that 5-HT1A agonists such as serotonin, 8-OH-DPAT, and ipsapirone competed with equal high affinities for [3H]spiroxatrine or [3H]8-OH-DPAT-labelled 5-HT1A receptors. ipsapirone 95-105 5-hydroxytryptamine receptor 1A Rattus norvegicus 189-195 2894698-4 1988 Another 5-HT 1A agonist, ipsapirone (10-20 mg/kg), blocked potentiated startle only at a very high dose (40 mg/kg). ipsapirone 25-35 5-hydroxytryptamine receptor 1A Homo sapiens 8-15 2887435-7 1987 Thus, the subpopulation of 5-HT1A receptors may mediate the behavioral effects of these compounds in animals and, in turn, the anxiolytic effects of buspirone and ipsapirone in humans. ipsapirone 163-173 5-hydroxytryptamine receptor 1A Homo sapiens 27-33 2886925-0 1987 Piperazine derivatives including the putative anxiolytic drugs, buspirone and ipsapirone, are agonists at 5-HT1A receptors negatively coupled with adenylate cyclase in hippocampal neurons. ipsapirone 78-88 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 106-112 3496228-6 1987 The corresponding values for the 5HT1A selective agonists 8-OH-DPAT and ipsapirone were 1.3 and 33 nmol/kg. ipsapirone 72-82 5-hydroxytryptamine receptor 1A Homo sapiens 33-38 2951504-5 1987 5-HT1A selective agents such as 8-OH-DPAT, ipsapirone, and buspirone display micromolar affinities for these sites. ipsapirone 43-53 5-hydroxytryptamine receptor 1A Bos taurus 0-6 2957498-9 1987 Thus, 3H-incorporation into the 63 kD band could be prevented by microM concentrations of 5-HT, 8-OH-DPAT and other selective 5-HT1A ligands such as isapirone. ipsapirone 149-158 5-hydroxytryptamine receptor 1A Rattus norvegicus 126-132 2889795-2 1987 It was found that ipsapirone inhibits induced by 8-OH-DPAT and 5-methoxydimethyltryptamine (agonists of 5-HT1A receptors) behavioural effects (flat body posture and forepaw treading) in normal and reserpinized rats. ipsapirone 18-28 5-hydroxytryptamine receptor 1A Rattus norvegicus 104-110 2889795-8 1987 The obtained results indicate that ipsapirone exhibits 5-HT1A antagonistic effect, and only at high doses it can also produce an inhibitory effect on 5-HT2 and the alpha 1-adrenergic function. ipsapirone 35-45 5-hydroxytryptamine receptor 1A Rattus norvegicus 55-61 22158750-0 1987 The 5-HT1A agonists 8-OH-DPAT, buspirone and ipsapirone attenuate stress-induced anorexia in rats. ipsapirone 45-55 5-hydroxytryptamine receptor 1A Rattus norvegicus 4-10 22158750-7 1987 The data suggest that 8-OH-DPAT, buspirone and ipsapirone attenuate stress-induced anorexia in rodents by a hyperphagic action on 5-HT(1A) receptors. ipsapirone 47-57 5-hydroxytryptamine receptor 1A Rattus norvegicus 130-137 3505364-2 1987 Following intravenous administration, the 5-HT1A selective compounds ipsapirone (TVX Q 7821) and LY 165163 potently inhibited single-unit activity in a dose-dependent manner whereas the 5-HT1B selective compounds, m-chlorophenylpiperazine (mCPP) and trifluoromethylphenylpiperazine (TFMPP), displayed only weak or irregular actions. ipsapirone 69-79 5-hydroxytryptamine receptor 1A Rattus norvegicus 42-48 2889611-0 1987 Isapirone is a partial agonist at 5-hydroxytryptamine 1A (5-HT1A) receptors in the rat hippocampus: electrophysiological evidence. ipsapirone 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 34-56 2889611-0 1987 Isapirone is a partial agonist at 5-hydroxytryptamine 1A (5-HT1A) receptors in the rat hippocampus: electrophysiological evidence. ipsapirone 0-9 5-hydroxytryptamine receptor 1A Rattus norvegicus 58-64 2889611-1 1987 Using iontophoretic techniques we observed that in vivo isapirone (TVX Q 7821), a selective ligand for the 5-HT1A binding site, at low ejection currents (5-30 nA) antagonised 5-HT and 8-hydroxy-2-(di-n-propylamino) tetralin (DPAT)-induced suppression of hippocampal unit activity, with little effect on baseline firing rate itself. ipsapirone 56-65 5-hydroxytryptamine receptor 1A Rattus norvegicus 107-113 2889611-4 1987 These data demonstrate that isapirone is a 5-HT1A receptor antagonist with partial agonist properties on 5-HT sensitive neurones in the rat hippocampus. ipsapirone 28-37 5-hydroxytryptamine receptor 1A Rattus norvegicus 43-49 3780856-1 1986 Ipsapirone, a putative, novel anxiolytic with a high affinity for 5-HT1A binding sites, suppressed neuronal activity in both the dorsal raphe nucleus and hippocampal formation of urethane-anesthetized rats. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 66-72 3780856-5 1986 These results indicate a potent effect of ipsapirone on neuronal activity in sites with a high density of 5-HT1A receptors. ipsapirone 42-52 5-hydroxytryptamine receptor 1A Rattus norvegicus 106-112 2946344-0 1986 Effect of chronic treatment with 5-HT1 agonist (8-OH-DPAT and RU 24969) and antagonist (isapirone) drugs on the behavioural responses of mice to 5-HT1 and 5-HT2 agonists. ipsapirone 88-97 5-hydroxytryptamine (serotonin) receptor 5A Mus musculus 145-156 2946344-0 1986 Effect of chronic treatment with 5-HT1 agonist (8-OH-DPAT and RU 24969) and antagonist (isapirone) drugs on the behavioural responses of mice to 5-HT1 and 5-HT2 agonists. ipsapirone 88-97 hypothermia due to alcohol sensitivity 2 Mus musculus 157-160 2946344-12 1986 These data suggest that chronic administration of the 5-HT1 agonists induces tolerance in their respective responses but not cross-tolerance, while chronic isapirone may down-regulate the 5-HT1A site in a matter analogous to that seen by 5-HT2 receptors following 5-HT2 receptor antagonists. ipsapirone 156-165 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 188-194 3746296-6 1986 This incorporation could be blocked when membranes were incubated with 1 microM of several agents that have high affinity for 5-HT1A sites [5-HT, 8-hydroxy-2-(di-n-propylamino)tetraline, TVX Q 7821, spiperone, buspirone, d-lysergic acid diethylamide, metergoline]. ipsapirone 187-197 5-hydroxytryptamine receptor 1A Rattus norvegicus 126-132 2878817-2 1986 During microiontophoretic application, (-)- but not (+)-propranolol rapidly and reversibly blocked the suppressant effects of the 5-HT1A-selective agonists ipsapirone (TVX Q 7821) and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). ipsapirone 156-166 5-hydroxytryptamine receptor 1A Homo sapiens 130-136 3505364-3 1987 Low microiontophoretic currents of ipsapirone and LY 165163 were also effective in suppressing spontaneous firing; dose-response relationships for the 5-HT1A compounds were indistinguishable from that of 5-HT itself. ipsapirone 35-45 5-hydroxytryptamine receptor 1A Rattus norvegicus 151-157 3505364-5 1987 In intracellular studies, ipsapirone and LY 165163, when added to the media bathing brain slices, mimicked the actions of 5-HT in hyperpolarizing dorsal raphe cell membranes and decreasing input resistance; however, the maximal effects of the 5-HT1A compounds on these membrane properties exceeded those of 5-HT. ipsapirone 26-36 5-hydroxytryptamine receptor 1A Rattus norvegicus 243-249 32000730-8 2020 When NF-kappaB was inhibited by BAY 11-7821, expressions of NF-kappaB, E-cadherin and Vimentin were measured. ipsapirone 32-43 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 5-14 2946344-13 1986 7 The data further demonstrate that chronic treatment with 8-OH-DPAT and isapirone alter postsynaptic 5-HT2 receptor function although 5-HT2 receptor number in the frontal cortex did not correlate with the behavioural change. ipsapirone 73-82 hypothermia due to alcohol sensitivity 2 Mus musculus 104-107 19094059-5 2008 Acute administration of the 5-HT(1A) receptor agonist ipsapirone decreased the rate of tryptophan hydroxylation in striatum, and this effect was significantly larger (+75%) in mice that drank ethanol than in those drinking water. ipsapirone 54-64 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 28-45 25307429-13 2014 In humans, ipsapirone reduced temperature in average with .55 C ranging between .1-1.4 C. CONCLUSIONS: 5-hydroxytryptamine receptor 1A (5HT(1A)) agonists significantly reduce infarct volumes in MCAO rats primarily because of the hypothermic drug effect. ipsapirone 11-21 5-hydroxytryptamine receptor 1A Rattus norvegicus 105-136 25307429-13 2014 In humans, ipsapirone reduced temperature in average with .55 C ranging between .1-1.4 C. CONCLUSIONS: 5-hydroxytryptamine receptor 1A (5HT(1A)) agonists significantly reduce infarct volumes in MCAO rats primarily because of the hypothermic drug effect. ipsapirone 11-21 5-hydroxytryptamine receptor 1A Rattus norvegicus 138-144 20378126-1 2010 BACKGROUND: This study was performed to test the hypothesis that 5-HT-1a receptors, as assessed by the cortisol (post-synaptic) and temperature (pre-synaptic) responses to the 5-HT-1a agonist, Ipsapirone (IPSAP), play a role in the regulation of impulsive aggressive behavior in human subjects. ipsapirone 193-203 5-hydroxytryptamine receptor 1A Homo sapiens 65-72 20378126-1 2010 BACKGROUND: This study was performed to test the hypothesis that 5-HT-1a receptors, as assessed by the cortisol (post-synaptic) and temperature (pre-synaptic) responses to the 5-HT-1a agonist, Ipsapirone (IPSAP), play a role in the regulation of impulsive aggressive behavior in human subjects. ipsapirone 205-210 5-hydroxytryptamine receptor 1A Homo sapiens 65-72 20661455-3 2010 Several 5-HT1A receptor agonists (buspirone, flesinoxan, ipsapirone) that preferentially desensitize 5-HT1A autoreceptors have been tested for augmentation of antidepressant drugs with mixed results. ipsapirone 57-67 5-hydroxytryptamine receptor 1A Homo sapiens 8-23 20661455-3 2010 Several 5-HT1A receptor agonists (buspirone, flesinoxan, ipsapirone) that preferentially desensitize 5-HT1A autoreceptors have been tested for augmentation of antidepressant drugs with mixed results. ipsapirone 57-67 5-hydroxytryptamine receptor 1A Homo sapiens 8-14 18948124-7 2009 In contrast, REM sleep was similarly reduced in 5-HT(7)(+/+) mice and 5-HT(7)(-/-) mice after treatment with the 5-HT(1A) receptor agonist ipsapirone. ipsapirone 139-149 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 113-130 18992726-3 2009 The present study investigated the temporal effects of both ethanol and ipsapirone on the expression of three NF-kappaB dependent genes, XIAP, Bcl-XL and catalase; these genes encode proteins that could potentially attenuate ethanol-induced apoptosis. ipsapirone 72-82 X-linked inhibitor of apoptosis Homo sapiens 137-141 18992726-3 2009 The present study investigated the temporal effects of both ethanol and ipsapirone on the expression of three NF-kappaB dependent genes, XIAP, Bcl-XL and catalase; these genes encode proteins that could potentially attenuate ethanol-induced apoptosis. ipsapirone 72-82 BCL2 like 1 Homo sapiens 143-149 18992726-3 2009 The present study investigated the temporal effects of both ethanol and ipsapirone on the expression of three NF-kappaB dependent genes, XIAP, Bcl-XL and catalase; these genes encode proteins that could potentially attenuate ethanol-induced apoptosis. ipsapirone 72-82 catalase Homo sapiens 154-162 18611291-4 2008 Four weeks after MDMA administration (20 mg/kg b.i.d for 4 d), a 2-fold increase in the potency of the 5-HT1A receptor agonist ipsapirone to inhibit the discharge of DRN 5-HT neurons and a larger hypothermic response to 8-OH-DPAT were observed in MDMA- compared to saline-treated mice. ipsapirone 127-137 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 103-118 28920103-10 2017 The 5-HT2A agonist TCB2 markedly reduced the affinity of the 5-HT1A agonist ipsapirone for the 5-HT1A agonist binding sites in the frontal lobe using the 5-HT1A radioligand binding assay. ipsapirone 76-86 5-hydroxytryptamine receptor 2A Homo sapiens 4-10 28920103-10 2017 The 5-HT2A agonist TCB2 markedly reduced the affinity of the 5-HT1A agonist ipsapirone for the 5-HT1A agonist binding sites in the frontal lobe using the 5-HT1A radioligand binding assay. ipsapirone 76-86 5-hydroxytryptamine receptor 1A Homo sapiens 61-67 28920103-10 2017 The 5-HT2A agonist TCB2 markedly reduced the affinity of the 5-HT1A agonist ipsapirone for the 5-HT1A agonist binding sites in the frontal lobe using the 5-HT1A radioligand binding assay. ipsapirone 76-86 5-hydroxytryptamine receptor 1A Homo sapiens 95-101 28920103-10 2017 The 5-HT2A agonist TCB2 markedly reduced the affinity of the 5-HT1A agonist ipsapirone for the 5-HT1A agonist binding sites in the frontal lobe using the 5-HT1A radioligand binding assay. ipsapirone 76-86 5-hydroxytryptamine receptor 1A Homo sapiens 95-101 18992726-10 2009 Importantly, treatment with ipsapirone augmented the activity of catalase and the expression of Bcl-XL, XIAP, and catalase in ethanol-treated neurons at later time points. ipsapirone 28-38 catalase Homo sapiens 65-73 18992726-10 2009 Importantly, treatment with ipsapirone augmented the activity of catalase and the expression of Bcl-XL, XIAP, and catalase in ethanol-treated neurons at later time points. ipsapirone 28-38 BCL2 like 1 Homo sapiens 96-102 18992726-10 2009 Importantly, treatment with ipsapirone augmented the activity of catalase and the expression of Bcl-XL, XIAP, and catalase in ethanol-treated neurons at later time points. ipsapirone 28-38 X-linked inhibitor of apoptosis Homo sapiens 104-108 18992726-10 2009 Importantly, treatment with ipsapirone augmented the activity of catalase and the expression of Bcl-XL, XIAP, and catalase in ethanol-treated neurons at later time points. ipsapirone 28-38 catalase Homo sapiens 114-122 16687129-5 2006 In the present study, we used quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) to determine the effects of 50mM ethanol and 100nM of ipsapirone, a 5-HT(1A) agonist, on the expression of several NF-kappaB-dependent antiapoptotic genes: X-linked inhibitor of apoptosis protein (XIAP), cIAP1, cIAP2, Bcl-2, and Bcl-xl. ipsapirone 164-174 5-hydroxytryptamine receptor 1A Homo sapiens 178-185 16687129-5 2006 In the present study, we used quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) to determine the effects of 50mM ethanol and 100nM of ipsapirone, a 5-HT(1A) agonist, on the expression of several NF-kappaB-dependent antiapoptotic genes: X-linked inhibitor of apoptosis protein (XIAP), cIAP1, cIAP2, Bcl-2, and Bcl-xl. ipsapirone 164-174 X-linked inhibitor of apoptosis Homo sapiens 266-305 16687129-5 2006 In the present study, we used quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) to determine the effects of 50mM ethanol and 100nM of ipsapirone, a 5-HT(1A) agonist, on the expression of several NF-kappaB-dependent antiapoptotic genes: X-linked inhibitor of apoptosis protein (XIAP), cIAP1, cIAP2, Bcl-2, and Bcl-xl. ipsapirone 164-174 X-linked inhibitor of apoptosis Homo sapiens 307-311 16687129-5 2006 In the present study, we used quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) to determine the effects of 50mM ethanol and 100nM of ipsapirone, a 5-HT(1A) agonist, on the expression of several NF-kappaB-dependent antiapoptotic genes: X-linked inhibitor of apoptosis protein (XIAP), cIAP1, cIAP2, Bcl-2, and Bcl-xl. ipsapirone 164-174 baculoviral IAP repeat containing 2 Homo sapiens 314-319 16687129-5 2006 In the present study, we used quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) to determine the effects of 50mM ethanol and 100nM of ipsapirone, a 5-HT(1A) agonist, on the expression of several NF-kappaB-dependent antiapoptotic genes: X-linked inhibitor of apoptosis protein (XIAP), cIAP1, cIAP2, Bcl-2, and Bcl-xl. ipsapirone 164-174 baculoviral IAP repeat containing 3 Homo sapiens 321-326 16687129-5 2006 In the present study, we used quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) to determine the effects of 50mM ethanol and 100nM of ipsapirone, a 5-HT(1A) agonist, on the expression of several NF-kappaB-dependent antiapoptotic genes: X-linked inhibitor of apoptosis protein (XIAP), cIAP1, cIAP2, Bcl-2, and Bcl-xl. ipsapirone 164-174 BCL2 apoptosis regulator Homo sapiens 328-333 16687129-5 2006 In the present study, we used quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) to determine the effects of 50mM ethanol and 100nM of ipsapirone, a 5-HT(1A) agonist, on the expression of several NF-kappaB-dependent antiapoptotic genes: X-linked inhibitor of apoptosis protein (XIAP), cIAP1, cIAP2, Bcl-2, and Bcl-xl. ipsapirone 164-174 BCL2 like 1 Homo sapiens 339-345 16687129-6 2006 We also investigated the effects of ethanol and ipsapirone on the expression of the gene encoding the 5-HT(1A) receptor. ipsapirone 48-58 5-hydroxytryptamine receptor 1A Homo sapiens 102-119 16687129-8 2006 Importantly, the ethanol-mediated reduction in the expression of XIAP and Bcl-xl was prevented by co-treatment with ipsapirone. ipsapirone 116-126 X-linked inhibitor of apoptosis Homo sapiens 65-69 16687129-8 2006 Importantly, the ethanol-mediated reduction in the expression of XIAP and Bcl-xl was prevented by co-treatment with ipsapirone. ipsapirone 116-126 BCL2 like 1 Homo sapiens 74-80 16687129-10 2006 Moreover, the protective effects of ipsapirone on ethanol-treated neurons might involve their ability to prevent the reduction of XIAP and Bcl-xl. ipsapirone 36-46 X-linked inhibitor of apoptosis Homo sapiens 130-134 16687129-10 2006 Moreover, the protective effects of ipsapirone on ethanol-treated neurons might involve their ability to prevent the reduction of XIAP and Bcl-xl. ipsapirone 36-46 BCL2 like 1 Homo sapiens 139-145 16687129-11 2006 Although ipsapirone treatment decreased the expression of cIAP1, Bcl-2, and Bcl-xl in control neurons, our prior studies suggest that their survival is not reduced by ipsapirone. ipsapirone 9-19 baculoviral IAP repeat containing 2 Homo sapiens 58-63 16687129-11 2006 Although ipsapirone treatment decreased the expression of cIAP1, Bcl-2, and Bcl-xl in control neurons, our prior studies suggest that their survival is not reduced by ipsapirone. ipsapirone 9-19 BCL2 apoptosis regulator Homo sapiens 65-70 16687129-11 2006 Although ipsapirone treatment decreased the expression of cIAP1, Bcl-2, and Bcl-xl in control neurons, our prior studies suggest that their survival is not reduced by ipsapirone. ipsapirone 9-19 BCL2 like 1 Homo sapiens 76-82 16687129-12 2006 We also observed an increased expression of the 5-HT(1A) receptor in ipsapirone-treated control neurons. ipsapirone 69-79 5-hydroxytryptamine receptor 1A Homo sapiens 48-65 16219031-4 2005 Recording of DRN serotonergic neurons in brainstem slices showed that GR 205171 treatment reduced (by approximately 1.5 fold) the potency of the 5-HT 1A receptor agonist, ipsapirone, to inhibit cell firing. ipsapirone 171-181 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 145-161 12798971-3 2003 The reductions of both 5-HT neurons and S100B-positive glia were prevented by maternal treatment with a 5-HT(1A) agonist (i.e., ipsapirone or buspirone). ipsapirone 128-138 S100 calcium binding protein B Rattus norvegicus 40-45 15939086-2 2005 We injected a 5-HT1A receptor agonist (ipsapirone) or antagonist (Way 100635) 1 h before injections of BrdU in neonates of both genders between days 2-4, a peak time of dentate gyrus granule cell proliferation. ipsapirone 39-49 5-hydroxytryptamine receptor 1A Homo sapiens 14-29 15158072-1 2004 Previously, this laboratory showed that in utero and in vitro ethanol exposure significantly reduces developing serotonin (5-HT) neurons and that treatment with a 5-HT1A agonist such as buspirone or ipsapirone prevents the ethanol-associated loss. ipsapirone 199-209 5-hydroxytryptamine receptor 1A Homo sapiens 163-169 15158072-6 2004 It also appears that the 5-HT1A agonist ipsapirone provides neuroprotection to these neurons by reducing apoptosis. ipsapirone 40-50 5-hydroxytryptamine receptor 1A Homo sapiens 25-31 12729940-1 2003 Blunted neuroendocrine and physiological responses to the selective 5-HT(1A) receptor agonist, ipsapirone, have been observed in patients with panic disorder and/or agoraphobia (PDA). ipsapirone 95-105 5-hydroxytryptamine receptor 1A Homo sapiens 68-85 16081165-8 2005 These analyses also provide support for the involvement of the PI-3K pathway; ipsapirone stimulated the phosphorylation of Akt in control and ethanol-treated neurons, and these effects were antagonized by LY294002. ipsapirone 78-88 AKT serine/threonine kinase 1 Homo sapiens 123-126 12970382-5 2003 In contrast, the prototypical 5-HT1A receptor agonists buspirone, ipsapirone, and 8-(hydroxy-2-(di-n-propylamino)tetralin, and also flesinoxan and eptapirone, were virtually inactive (< or =5). ipsapirone 66-76 5-hydroxytryptamine receptor 1A Homo sapiens 30-45 12354565-7 2002 Other 5-HT(1A) receptor agonists (buspirone, gepirone and ipsapirone) also reduced phospho-Erk1/2 levels in hippocampus. ipsapirone 58-68 5-hydroxytryptamine receptor 1A Rattus norvegicus 6-13 12467943-6 2002 MCPP and ipsapirone elevated cortisol, ACTH and prolactin. ipsapirone 9-19 proopiomelanocortin Homo sapiens 39-43 12480124-8 2002 We also evaluated the effects of ethanol and ipsapirone on astroglial content of S100B. ipsapirone 45-55 S100 calcium binding protein B Homo sapiens 81-86 12480124-10 2002 However, treatment with 100 nM ipsapirone, a 5-HT(1A) agonist, between the 6th and 7th day in vitro, increased astroglial release of S100B 2- to 3-fold. ipsapirone 31-41 5-hydroxytryptamine receptor 1A Homo sapiens 45-52 12480124-10 2002 However, treatment with 100 nM ipsapirone, a 5-HT(1A) agonist, between the 6th and 7th day in vitro, increased astroglial release of S100B 2- to 3-fold. ipsapirone 31-41 S100 calcium binding protein B Homo sapiens 133-138 12354565-7 2002 Other 5-HT(1A) receptor agonists (buspirone, gepirone and ipsapirone) also reduced phospho-Erk1/2 levels in hippocampus. ipsapirone 58-68 mitogen activated protein kinase 3 Rattus norvegicus 91-97 12093600-2 2002 Although many of these patients are regular smokers, it has not been examined whether psychological or neurobiological effects induced by the selective 5-HT1A-receptor agonist, ipsapirone, are affected by the smoking status of the patients. ipsapirone 177-187 5-hydroxytryptamine receptor 1A Homo sapiens 152-167 11718831-2 2001 However, maternal treatment with a 5-HT(1A) agonist, e.g., buspirone or ipsapirone, between gestational days 13 and 20 prevented most of the ethanol-associated changes to developing 5-HT neurons and S100B-immunopositive glia in offspring. ipsapirone 72-82 S100 calcium binding protein B Rattus norvegicus 199-204 10947809-8 2000 administration of ipsapirone (a 5-HT1A agonist), and an increased 5-HT outflow in the substantia nigra upon local application of GR 127935 (a 5-HT1B/1D antagonist) were observed in 5-HTT+/+ mice. ipsapirone 18-28 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 32-38 11588191-4 2001 Furthermore, a approximately 10-fold decrease in the potency of the 5-HT(1A) receptor agonist ipsapirone to inhibit the discharge of serotoninergic neurons in the dorsal raphe nucleus within brainstem slices, and reduced hypothermic response to 8-OH-DPAT, were noted in NK1-/- versus NK1+/+ mice. ipsapirone 94-104 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 68-85 11588191-4 2001 Furthermore, a approximately 10-fold decrease in the potency of the 5-HT(1A) receptor agonist ipsapirone to inhibit the discharge of serotoninergic neurons in the dorsal raphe nucleus within brainstem slices, and reduced hypothermic response to 8-OH-DPAT, were noted in NK1-/- versus NK1+/+ mice. ipsapirone 94-104 tachykinin 1 Mus musculus 270-273 11588191-4 2001 Furthermore, a approximately 10-fold decrease in the potency of the 5-HT(1A) receptor agonist ipsapirone to inhibit the discharge of serotoninergic neurons in the dorsal raphe nucleus within brainstem slices, and reduced hypothermic response to 8-OH-DPAT, were noted in NK1-/- versus NK1+/+ mice. ipsapirone 94-104 tachykinin 1 Mus musculus 284-287 11432685-6 2001 In contrast, the increases of cortisol observed after administration of the 5-HT1A agonist ipsapirone were of the same magnitude during the pre- and post-training challenge sessions. ipsapirone 91-101 5-hydroxytryptamine receptor 1A Homo sapiens 76-82 11245702-3 2001 By contrast, the 5-HT(1A) receptor agonists ipsapirone and 5-carboxamidotryptamine inhibited the discharge in both groups. ipsapirone 44-54 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 17-34 11245702-7 2001 As expected from their mediation through 5-HT(1A) receptors, the effects of ipsapirone and 5-carboxamidotryptamine were competitively inhibited by the selective 5-HT(1A) antagonist WAY 100635 in both groups. ipsapirone 76-86 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 41-48 11245702-7 2001 As expected from their mediation through 5-HT(1A) receptors, the effects of ipsapirone and 5-carboxamidotryptamine were competitively inhibited by the selective 5-HT(1A) antagonist WAY 100635 in both groups. ipsapirone 76-86 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 161-168 10947809-8 2000 administration of ipsapirone (a 5-HT1A agonist), and an increased 5-HT outflow in the substantia nigra upon local application of GR 127935 (a 5-HT1B/1D antagonist) were observed in 5-HTT+/+ mice. ipsapirone 18-28 5-hydroxytryptamine (serotonin) receptor 1B Mus musculus 142-148 10928305-0 2000 Ipsapirone challenge in aggressive men shows an inverse correlation between 5-HT1A receptor function and aggression. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Homo sapiens 76-91 10864964-5 2000 Conversely, both a decrease in 5-HT(1A)-mediated [(35)S]GTP-gamma-S binding and a reduced potency of the 5-HT(1A) receptor agonist ipsapirone to inhibit neuronal firing were observed in the dorsal raphe nucleus of antisense plasmid-injected rats. ipsapirone 131-141 5-hydroxytryptamine receptor 1A Rattus norvegicus 31-38 10864964-5 2000 Conversely, both a decrease in 5-HT(1A)-mediated [(35)S]GTP-gamma-S binding and a reduced potency of the 5-HT(1A) receptor agonist ipsapirone to inhibit neuronal firing were observed in the dorsal raphe nucleus of antisense plasmid-injected rats. ipsapirone 131-141 5-hydroxytryptamine receptor 1A Rattus norvegicus 105-112 10962247-3 2000 For example, acute administration of a selective 5-HT(1A) receptor agonist, such as ipsapirone, decreases body temperature and increases plasma cortisol through activation of pre- and postsynaptic 5-HT(1A) receptors, respectively. ipsapirone 84-94 5-hydroxytryptamine receptor 1A Homo sapiens 49-66 10818278-1 2000 Depression has been shown in some studies to be associated with a reduction in hypothalamic 5-HT(1A) receptor function, as indicated by reduced hormone and/or hypothermic responses to 5-HT(1A) agonists such as ipsapirone. ipsapirone 210-220 5-hydroxytryptamine receptor 1A Homo sapiens 92-109 10876026-5 2000 To test our hypothesis, we determined the effects of in utero ethanol exposure and maternal treatments with the 5-HT(1A) agonists ipsapirone and buspirone on S100B immunopositive glial cells. ipsapirone 130-140 5-hydroxytryptamine receptor 1A Rattus norvegicus 112-119 10867965-5 2000 RESULTS: In the absence of EEDQ, each 5-HT1A agonist produced full effects, the rank order of potency being: S 14506 > 8-OH-DPAT > buspirone > ipsapirone. ipsapirone 152-162 5-hydroxytryptamine receptor 1A Rattus norvegicus 38-44 10647095-1 1999 Although the serotonin (5-HT)1A receptor agonist ipsapirone reduces ethanol intake in a variety of animal models of alcoholism, such effects have only been reported in models based on nonoperant behavior (e.g., two-bottle choice procedures). ipsapirone 49-59 5-hydroxytryptamine receptor 1A Rattus norvegicus 13-40 10445378-0 1999 Low doses of ipsapirone increase growth hormone but not oxytocin secretion in normal male and female subjects. ipsapirone 13-23 growth hormone 1 Homo sapiens 33-47 10467974-1 1999 BACKGROUND: The selective 5-HT1A receptor agonist ipsapirone causes dose-dependent decrease in body temperature and increase in adrenocorticotropic hormone (ACTH) and cortisol release in humans. ipsapirone 50-60 5-hydroxytryptamine receptor 1A Homo sapiens 26-41 10467974-1 1999 BACKGROUND: The selective 5-HT1A receptor agonist ipsapirone causes dose-dependent decrease in body temperature and increase in adrenocorticotropic hormone (ACTH) and cortisol release in humans. ipsapirone 50-60 proopiomelanocortin Homo sapiens 128-155 10467974-1 1999 BACKGROUND: The selective 5-HT1A receptor agonist ipsapirone causes dose-dependent decrease in body temperature and increase in adrenocorticotropic hormone (ACTH) and cortisol release in humans. ipsapirone 50-60 proopiomelanocortin Homo sapiens 157-161 10467974-2 1999 These responses are attenuated by 5-HT1A receptor antagonists, suggesting that hypothermia, ACTH and cortisol release induced by ipsapirone are indeed mediated by 5-HT1A receptors and that these responses provide a valid index of 5-HT1A receptor function in humans. ipsapirone 129-139 5-hydroxytryptamine receptor 1A Homo sapiens 34-49 10467974-2 1999 These responses are attenuated by 5-HT1A receptor antagonists, suggesting that hypothermia, ACTH and cortisol release induced by ipsapirone are indeed mediated by 5-HT1A receptors and that these responses provide a valid index of 5-HT1A receptor function in humans. ipsapirone 129-139 proopiomelanocortin Homo sapiens 92-96 10467974-2 1999 These responses are attenuated by 5-HT1A receptor antagonists, suggesting that hypothermia, ACTH and cortisol release induced by ipsapirone are indeed mediated by 5-HT1A receptors and that these responses provide a valid index of 5-HT1A receptor function in humans. ipsapirone 129-139 5-hydroxytryptamine receptor 1A Homo sapiens 34-40 10467974-2 1999 These responses are attenuated by 5-HT1A receptor antagonists, suggesting that hypothermia, ACTH and cortisol release induced by ipsapirone are indeed mediated by 5-HT1A receptors and that these responses provide a valid index of 5-HT1A receptor function in humans. ipsapirone 129-139 5-hydroxytryptamine receptor 1A Homo sapiens 163-178 10599847-2 1999 This treatment produced a significant decrease in the potency of the 5-HT1A agonist ipsapirone to inhibit the electrical activity of serotoninergic neurons in the dorsal raphe nucleus, without modifying 5-HT1A receptor binding in various brain areas. ipsapirone 84-94 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 69-75 10445378-3 1999 RESULTS: Stimulation of GH secretion by ipsapirone was significantly greater in male compared to female subjects, with no apparent effect of age. ipsapirone 40-50 growth hormone 1 Homo sapiens 24-26 10327431-0 1999 5-HT1A receptor function in normal subjects on clinical doses of fluoxetine: blunted temperature and hormone responses to ipsapirone challenge. ipsapirone 122-132 5-hydroxytryptamine receptor 1A Homo sapiens 0-15 10080245-2 1999 An anxiolytic effect of the 5-HT1A agonist ipsapirone (0.25, 0.75, and 2.25 mg/kg) was detected by risk-assessment and scanning but not by percentage of open-arm entries and time spent on open arms. ipsapirone 43-53 5-hydroxytryptamine receptor 1A Rattus norvegicus 28-34 10379620-4 1999 RESULTS: Firstly, the 5-HT1A agonists 8-OH-DPAT and ipsapirone attenuated the extrapyramidal-like effects of haloperidol and risperidone more than their therapeutic-like effects; this was not observed for tropapride, where all of its effects were markedly attenuated. ipsapirone 52-62 5-hydroxytryptamine receptor 1A Homo sapiens 22-28 10379620-6 1999 Thirdly, neuroleptics apparently differed in their sensitivity to interactions with 5-HT1A agonists inasmuch as 8-OH-DPAT and ipsapirone attenuated the effects of tropapride on hindlimb retraction times more than those of haloperidol or risperidone. ipsapirone 126-136 5-hydroxytryptamine receptor 1A Homo sapiens 84-90 10359479-0 1999 Serotonin hypothesis of winter depression: behavioral and neuroendocrine effects of the 5-HT(1A) receptor partial agonist ipsapirone in patients with seasonal affective disorder and healthy control subjects. ipsapirone 122-132 5-hydroxytryptamine receptor 1A Homo sapiens 88-105 9988364-0 1998 Neuroendocrine and hypothermic effects of 5-HT1A receptor stimulation with ipsapirone in healthy men: a placebo-controlled study. ipsapirone 75-85 5-hydroxytryptamine receptor 1A Homo sapiens 42-57 9885795-5 1999 In contrast, the increase of cortisol and the hypothermia observed after administration of the 5-HT1A agonist ipsapirone were of the same magnitude in both groups. ipsapirone 110-120 5-hydroxytryptamine receptor 1A Homo sapiens 95-101 10512084-5 1999 The selective 5-HT1A receptor antagonist WAY 100635 (0.15 mg/kg), attenuated the hypothermia induced by the partial agonists, ipsapirone (10 mg/kg) and eltoprazine (10 mg/kg). ipsapirone 126-136 5-hydroxytryptamine receptor 1A Homo sapiens 14-29 9829648-1 1998 Thirty-one human subjects were administered a neuroendocrine challenge with the 5-HT1a agonist ipsapirone after completing six sessions of a laboratory measure of aggression, the Point Subtraction Aggression Paradigm (PSAP), in order to determine if a laboratory measure of aggression was related to serotonin function. ipsapirone 95-105 5-hydroxytryptamine receptor 1A Homo sapiens 80-86 9690691-1 1998 Ipsapirone, an azapirone with 5-hydroxytryptamine (5-HT1A) partial agonist activity, has been shown in preliminary studies to be effective in the treatment of major depressive disorder. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Homo sapiens 51-57 9585797-0 1998 Blunted 5-HT1A-receptor agonist-induced corticotropin and cortisol responses after long-term ipsapirone and fluoxetine administration to healthy subjects. ipsapirone 93-103 5-hydroxytryptamine receptor 1A Homo sapiens 8-23 10027850-8 1999 Furthermore, the data provide evidence for a major involvement of these 5-HT1A receptors in the modulation of aggressive behavior by 8-OH-DPAT, ipsapirone, buspirone, and eltoprazine. ipsapirone 144-154 5-hydroxytryptamine receptor 1A Rattus norvegicus 72-78 9918598-4 1999 Systemic administration of selective 5-HT1A agonists, 8-hydroxy-2-(di-n-propylamino)tetralin, buspirone, ipsapirone, and flesinoxan produced a dose-dependent inhibition of neuronal activity. ipsapirone 105-115 5-hydroxytryptamine receptor 1A Rattus norvegicus 37-43 10218869-0 1999 Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment. ipsapirone 87-97 cholecystokinin Rattus norvegicus 29-32 10218869-1 1999 The effect of chronic fluoxetine and ipsapirone treatment on the anxiogenic effect of centrally administered cholecystokinin (CCK) was studied in the social interaction test in male Sprague-Dawley rats. ipsapirone 37-47 cholecystokinin Rattus norvegicus 126-129 10218869-8 1999 Chronic treatment with ipsapirone (5 mg/kg per day, 3 weeks) partially attenuated the effects of CCK-8 (1 nmol/rat, i.c.v.). ipsapirone 23-33 cholecystokinin Rattus norvegicus 97-100 11281940-0 1998 Effectiveness of ipsapirone, a 5-HT-1A partial agonist, in major depressive disorder: support for the role of 5-HT-1A receptors in the mechanism of action of serotonergic antidepressants. ipsapirone 17-27 5-hydroxytryptamine receptor 1A Homo sapiens 31-38 11281940-10 1998 Results of this study demonstrate that ipsapirone, at a dose of 7.5 mg t.i.d., is an effective antidepressant agent in the treatment of MDD, supporting the hypothesised role of 5-HT-1A receptors in the mechanism of action of serotonin reuptake inhibitors. ipsapirone 39-49 5-hydroxytryptamine receptor 1A Homo sapiens 177-184 9632218-1 1998 In a series of experiments, we investigated the interaction between the calcium channel antagonist, nifedipine, and the 5-HT1A agonist, ipsapirone. ipsapirone 136-146 5-hydroxytryptamine receptor 1A Homo sapiens 120-126 9988364-7 1998 Ipsapirone caused clear and significant elevations in adrenocorticotrophin (ACTH), cortisol (CORT), prolactin (PRL), and growth hormone (GH) release. ipsapirone 0-10 cortistatin Homo sapiens 93-97 9988364-7 1998 Ipsapirone caused clear and significant elevations in adrenocorticotrophin (ACTH), cortisol (CORT), prolactin (PRL), and growth hormone (GH) release. ipsapirone 0-10 prolactin Homo sapiens 100-109 9988364-7 1998 Ipsapirone caused clear and significant elevations in adrenocorticotrophin (ACTH), cortisol (CORT), prolactin (PRL), and growth hormone (GH) release. ipsapirone 0-10 prolactin Homo sapiens 111-114 9988364-7 1998 Ipsapirone caused clear and significant elevations in adrenocorticotrophin (ACTH), cortisol (CORT), prolactin (PRL), and growth hormone (GH) release. ipsapirone 0-10 growth hormone 1 Homo sapiens 121-135 9988364-7 1998 Ipsapirone caused clear and significant elevations in adrenocorticotrophin (ACTH), cortisol (CORT), prolactin (PRL), and growth hormone (GH) release. ipsapirone 0-10 growth hormone 1 Homo sapiens 137-139 9372553-5 1997 ), daily for 3-7 days) significantly reduced the potency of the 5-HT1A receptor agonist ipsapirone to inhibit the firing rate of serotoninergic neurons. ipsapirone 88-98 5-hydroxytryptamine receptor 1A Rattus norvegicus 64-70 9884116-10 1998 The anxiolytic agents diazepam (benzodiazepine), buspirone and ipsapirone (5-HT1A agonists) as well as ritanserin (5-HT2 antagonist) selectively impaired inhibitory avoidance while leaving one-way escape unchanged. ipsapirone 63-73 5-hydroxytryptamine receptor 1A Rattus norvegicus 75-81 9616799-17 1997 Using a serotonergic probe of 5-HT1A receptors, several investigators examined ipsapirone-induced prolactin release in suicidal patients and did not find it different that that of control subjects. ipsapirone 79-89 5-hydroxytryptamine receptor 1A Homo sapiens 30-36 9616799-17 1997 Using a serotonergic probe of 5-HT1A receptors, several investigators examined ipsapirone-induced prolactin release in suicidal patients and did not find it different that that of control subjects. ipsapirone 79-89 prolactin Homo sapiens 98-107 9397426-1 1997 Hypothermic and hormonal responses to a challenge with a selective 5-HT1A receptor agonist ipsapirone are considered to provide an index of 5-HT1A receptor function in humans. ipsapirone 91-101 5-hydroxytryptamine receptor 1A Homo sapiens 67-82 9397426-1 1997 Hypothermic and hormonal responses to a challenge with a selective 5-HT1A receptor agonist ipsapirone are considered to provide an index of 5-HT1A receptor function in humans. ipsapirone 91-101 5-hydroxytryptamine receptor 1A Homo sapiens 140-155 9355105-7 1997 These effects induced by ADX were reduced within 72 hrs by ipsapirone (1 mg/kg), a 5HT1A receptor agonist. ipsapirone 59-69 5-hydroxytryptamine receptor 1A Rattus norvegicus 83-88 9219866-8 1997 The EEG power spectrum induced by pindolol tended to be opposite to what has previously been reported for ipsapirone, a 5-HT1A agonist. ipsapirone 106-116 5-hydroxytryptamine receptor 1A Homo sapiens 120-126 9303566-0 1997 Effect of acute and repeated versus sustained administration of the 5-HT1A receptor agonist ipsapirone: electrophysiological studies in the rat hippocampus and dorsal raphe. ipsapirone 92-102 5-hydroxytryptamine receptor 1A Rattus norvegicus 68-74 9303566-2 1997 Concurrent microiontophoretic application of ipsapirone did not attentuate the suppressant effect of 5-hydroxytyptamine (5-HT) on 5-HT neurons, but markedly decreased it when co-applied on CA3 pyramidal neurons in the dorsal hippocampus. ipsapirone 45-55 carbonic anhydrase 3 Rattus norvegicus 189-192 9303566-8 1997 In conclusion, long-term administration of ipsapirone most likely increases 5-HT neurotransmission by enhancing the tonic activation of postsynaptic 5-HT1A receptors. ipsapirone 43-53 5-hydroxytryptamine receptor 1A Rattus norvegicus 149-155 9303566-9 1997 Therefore, the use of sustained release preparation of 5-HT1A receptor agonists should not alter their therapeutic effectiveness in anxiety and affective disorders since the same effects on 5-HT1A receptor functions were produced in this rat model by the sustained and the repeated modes of administration of ipsapirone. ipsapirone 309-319 5-hydroxytryptamine receptor 1A Rattus norvegicus 190-196 9219875-4 1997 Tandospirone and ipsapirone each induced expression of Fos protein in the noradrenergic neurons of the locus coeruleus of conscious rats. ipsapirone 17-27 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 55-58 9226729-6 1997 Release of ACTH (but not cortisol) in response to ipsapirone challenge was significantly blunted in patients with CFS. ipsapirone 50-60 proopiomelanocortin Homo sapiens 11-15 9163561-3 1997 Tests for generalization and antagonism showed that compounds with agonistic action at the 5-HT1A receptor, such as 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), buspirone and ipsapirone all substituted for the flesinoxan cue. ipsapirone 182-192 5-hydroxytryptamine receptor 1A Homo sapiens 91-106 9503255-7 1997 The results clearly demonstrate that the ipsapirone induced decreases in body temperature and number of peripheral CD4+ cells are more pronounced in high impulsives. ipsapirone 41-51 CD4 molecule Homo sapiens 115-118 9105877-2 1997 Synaptic responses in the CA1 region of the dorsal hippocampus of alert, freely behaving male Wistar rats were reduced after acute injection of ipsapirone (1 or 2 mg/kg, i.p.). ipsapirone 144-154 carbonic anhydrase 1 Rattus norvegicus 26-29 9105877-11 1997 The data indicate that with repeated administration of ipsapirone, a prolongation and enhancement of the 5-HT1A receptor-mediated reduction in hippocampal excitatory synaptic transmission occurs. ipsapirone 55-65 5-hydroxytryptamine receptor 1A Rattus norvegicus 105-111 8863499-4 1996 Using microdialysis, we examined the modifications of 5-HT release induced by the selective 5-HT1A agonist ipsapirone in both neuronal pathways. ipsapirone 107-117 5-hydroxytryptamine receptor 1A Homo sapiens 92-98 8813534-0 1996 Ipsapirone enhances the dopamine outflow via 5-HT1A receptors in the rat prefrontal cortex. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 45-51 8840346-0 1996 Ipsapirone, a 5-HT1A agonist, suppresses REM sleep equally in unmedicated depressed patients and normal controls. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Homo sapiens 14-20 8840346-1 1996 To determine whether ipsapirone, a 5-HT1A agonist, differentially suppresses REM sleep in depressed patients compared with normal controls, we administered placebo, ipsapirone 10 mg, or ipsapirone 20 mg in a double-blind, random order before bedtime in 18 unmedicated patients with depression and 16 age-matched, gender-matched normal controls. ipsapirone 21-31 5-hydroxytryptamine receptor 1A Homo sapiens 35-41 8813534-3 1996 The above effects of ipsapirone were mimicked by buspirone (2.5 and 5 mg/kg), another 5-HT1A receptor agonist, but not 1-PP (1-pyrimidinylpiperazine, 5 mg/kg)-a centrally active metabolite of ipsapirone. ipsapirone 21-31 5-hydroxytryptamine receptor 1A Rattus norvegicus 86-92 8801584-6 1996 Diazepam (1 mg/kg) and the 5-HT1A agonist ipsapirone (0.5-10 mg/kg) significantly inhibited freezing behavior. ipsapirone 42-52 5-hydroxytryptamine receptor 1A Rattus norvegicus 27-33 8734905-0 1996 The 5-HT1A agonist ipsapirone enhances EEG slow wave activity in human sleep and produces a power spectrum similar to 5-HT2 blockade. ipsapirone 19-29 5-hydroxytryptamine receptor 1A Homo sapiens 4-10 8734905-6 1996 We propose that the spectral data following the lower ipsapirone dose reflect a net decrease of neuronal activity at 5-HT2 receptors, mediated through stimulation of somatodendritic autoreceptors in the raphe nuclei (presynaptic) and/or through stimulation of postsynaptic 5-HT1A receptors colocalized with 5-HT2 receptors. ipsapirone 54-64 5-hydroxytryptamine receptor 1A Homo sapiens 273-279 8788532-2 1996 Altogether 40 healthy male volunteers were given either a single dosage of the 5-HT1a-receptor agonist ipsapirone (10 mg) or a placebo (n = 20 each) in a double-blind randomized trial. ipsapirone 103-113 5-hydroxytryptamine receptor 1A Homo sapiens 79-94 8819647-17 1996 Activation of serotonin1A (5HT1A) receptors with the anti-anxiety drugs buspirone and ipsapirone reduces the firing rate of serotonergic neurons in the dorsal raphe nucleus in the midbrain and decreases the effect of stress on plasma renin concentrations. ipsapirone 86-96 5-hydroxytryptamine receptor 1A Rattus norvegicus 27-32 8819647-17 1996 Activation of serotonin1A (5HT1A) receptors with the anti-anxiety drugs buspirone and ipsapirone reduces the firing rate of serotonergic neurons in the dorsal raphe nucleus in the midbrain and decreases the effect of stress on plasma renin concentrations. ipsapirone 86-96 renin Rattus norvegicus 234-239 8916073-3 1996 In studies 1 and 2 responsivity to a serotonergic (5-HT) challenge by a 5-HT1a receptor agonist (ipsapirone) was investigated by drug-induced prolactin (PRL) and cortisol responses, as well as by emotional states and behavioral measures. ipsapirone 97-107 5-hydroxytryptamine receptor 1A Homo sapiens 72-87 9026379-2 1996 It has also been reported to inhibit the effects of other 5-HT1A partial agonists such as ipsapirone and buspirone on hormone secretion and body temperature in man, indicating its antagonist action at 5-HT1A receptors in man. ipsapirone 90-100 5-hydroxytryptamine receptor 1A Homo sapiens 58-64 9026379-2 1996 It has also been reported to inhibit the effects of other 5-HT1A partial agonists such as ipsapirone and buspirone on hormone secretion and body temperature in man, indicating its antagonist action at 5-HT1A receptors in man. ipsapirone 90-100 5-hydroxytryptamine receptor 1A Homo sapiens 201-207 8637392-2 1996 A variety of drugs including precursors of 5HT such as 5HTP, drugs which release 5HT such as fenfluramine and drugs which act directly on 5HT receptors such as ipsapirone increase cortisol and ACTH concentrations. ipsapirone 160-170 proopiomelanocortin Homo sapiens 193-197 8788529-0 1996 The anxiolytic serotonin 5-HT1A receptor agonists buspirone, ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum. ipsapirone 61-71 5-hydroxytryptamine receptor 1A Rattus norvegicus 25-31 8614705-5 1995 The 5-HT1A receptor agonists busipirone, ipsapirone, and 8-OH-DPAT decreased aggression in RI and MA, but simultaneously led to a marked decrease in social interest and activity, indicative of a nonspecific antiaggressive profile. ipsapirone 41-51 5-hydroxytryptamine receptor 1A Canis lupus familiaris 4-19 8666006-0 1995 Presynaptic 5-HT1A receptors mediate the effect of ipsapirone on punished responding in rats. ipsapirone 51-61 5-hydroxytryptamine receptor 1A Rattus norvegicus 12-18 8577795-5 1995 (-)-Pindolol failed to reverse the effects of ipsapirone on sleep and W. The present results tend to indicate that increased W after acute administration of buspirone, ipsapirone, or gepirone depends upon the activation of postsynaptic 5-HT1A receptors. ipsapirone 168-178 5-hydroxytryptamine receptor 1A Rattus norvegicus 236-242 8666006-7 1995 The results suggest that ipsapirone releases behaviour that is suppressed by punishment by stimulating presynaptic 5-HT1A receptors. ipsapirone 25-35 5-hydroxytryptamine receptor 1A Rattus norvegicus 115-121 7552242-5 1995 The reductions in MAP-2 and synaptophysin-IR were reversed by 3 days of treatment with dexamethasone (10 mg/l drinking water) or ipsapirone, a 5-HT1A agonist (1 mg/kg s.c.). ipsapirone 129-139 microtubule-associated protein 2 Rattus norvegicus 18-23 8539333-2 1995 5-HT1A receptors have been cloned and a variety of selective agonists, such as the aminotetraline 8-OH-DPAT and the pyrimidinylpiperazine ipsapirone, have become available. ipsapirone 138-148 5-hydroxytryptamine receptor 1A Homo sapiens 0-6 8524984-2 1995 Irrespective of age or gender, ipsapirone induced a significant reduction in body temperature relative to placebo and a significant increase in ACTH and cortisol release. ipsapirone 31-41 proopiomelanocortin Homo sapiens 144-148 8524984-8 1995 Adverse effects of ipsapirone were also more marked in elderly females and were correlated with ACTH and cortisol responses. ipsapirone 19-29 proopiomelanocortin Homo sapiens 96-100 7667331-2 1995 Lowering of body core temperature was induced by either exposure to a cold environment at a temperature of 5 degrees C (CT) or by a single dose of the 5-HT1A agonist ipsapirone (IPS). ipsapirone 166-176 5-hydroxytryptamine receptor 1A Homo sapiens 151-157 7552242-5 1995 The reductions in MAP-2 and synaptophysin-IR were reversed by 3 days of treatment with dexamethasone (10 mg/l drinking water) or ipsapirone, a 5-HT1A agonist (1 mg/kg s.c.). ipsapirone 129-139 synaptophysin Rattus norvegicus 28-41 7552242-5 1995 The reductions in MAP-2 and synaptophysin-IR were reversed by 3 days of treatment with dexamethasone (10 mg/l drinking water) or ipsapirone, a 5-HT1A agonist (1 mg/kg s.c.). ipsapirone 129-139 5-hydroxytryptamine receptor 1A Rattus norvegicus 143-149 7606493-0 1995 Anxiolytic effect of the 5-HT1A compounds 8-hydroxy-2-(di-n-propylamino) tetralin and ipsapirone in the social interaction paradigm: evidence of a presynaptic action. ipsapirone 86-96 5-hydroxytryptamine receptor 1A Rattus norvegicus 25-31 7777653-5 1995 The 5-HT1A agonist, 8-OH-DPAT, was able to attenuate the adrenocortical responses to acoustic stimulation, conditioned fear, IL-1 alpha, and cocaine administration, with ipsapirone also being effective in reducing the responses to acoustic stimulation and cocaine injection. ipsapirone 170-180 5-hydroxytryptamine receptor 1A Homo sapiens 4-10 7731493-4 1995 8-Hydroxy-2 (di-n-propylamino) tetralin (8-OH-DPAT) or ipsapirone (10(-5) M) significantly stimulated LHRH release. ipsapirone 55-65 gonadotropin releasing hormone 1 Rattus norvegicus 102-106 7753966-0 1995 The influence of ipsapirone, a 5-HT1A agonist, on sleep patterns of healthy subjects. ipsapirone 17-27 5-hydroxytryptamine receptor 1A Homo sapiens 31-37 7777653-5 1995 The 5-HT1A agonist, 8-OH-DPAT, was able to attenuate the adrenocortical responses to acoustic stimulation, conditioned fear, IL-1 alpha, and cocaine administration, with ipsapirone also being effective in reducing the responses to acoustic stimulation and cocaine injection. ipsapirone 170-180 interleukin 1 alpha Homo sapiens 125-135 7753966-1 1995 Ipsapirone is a new pyrimidinylpiperazine ligand specific for 5-HT1A receptors, with potential therapeutic use in affective disorders. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Homo sapiens 62-68 7705452-9 1994 Substantial (77%) blockade of [3H]WAY-100635 binding was achieved with the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), and the partial agonists, ipsapirone and buspirone. ipsapirone 178-188 5-hydroxytryptamine receptor 1A Homo sapiens 75-81 7532310-2 1994 Similarly, administration of various doses of ipsapirone (a 5-HT1A agonist) produced hypothermia that was significantly less in the FH rat strain relative to the Wistar rat strain. ipsapirone 46-56 5-hydroxytryptamine receptor 1A Rattus norvegicus 60-66 7701045-0 1994 Inhibition of REM sleep by ipsapirone, a 5HT1A agonist, in normal volunteers. ipsapirone 27-37 5-hydroxytryptamine receptor 1A Homo sapiens 41-46 7701045-2 1994 Ipsapirone is a relatively selective 5HT1A receptor agonist. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Homo sapiens 37-51 8029269-1 1994 Rats were trained to discriminate 0.3 mg/kg (IP) flesinoxan from saline in a standard two-lever operant procedure and thereafter subjected to generalization and antagonism tests with the 5-HT1A receptor agonist ipsapirone and the beta-adrenergic/5-HT1 receptor antagonist pindolol. ipsapirone 211-221 5-hydroxytryptamine receptor 1A Rattus norvegicus 187-193 7842512-1 1994 Repeated treatment of primary cultures of fetal rat septal neurons with 5-HT1A receptor agonists (8-OH-DPAT, ipsapirone, gepirone and buspirone) increased choline acetyltransferase activity after 6-7 days in culture. ipsapirone 109-119 5-hydroxytryptamine receptor 1A Rattus norvegicus 72-78 7842512-1 1994 Repeated treatment of primary cultures of fetal rat septal neurons with 5-HT1A receptor agonists (8-OH-DPAT, ipsapirone, gepirone and buspirone) increased choline acetyltransferase activity after 6-7 days in culture. ipsapirone 109-119 choline O-acetyltransferase Rattus norvegicus 155-180 7842512-2 1994 This effect was optimal with ipsapirone (+ 50-80% at 1 microM of the agonist), and could be prevented by potent 5-HT1A receptor antagonists such as (-)-tertatolol and (+)-WAY 100135. ipsapirone 29-39 5-hydroxytryptamine receptor 1A Rattus norvegicus 112-118 7993956-0 1994 Attenuation of hormone responses to the 5-HT1A agonist ipsapirone by long-term treatment with fluoxetine, but not desipramine, in male rats. ipsapirone 55-65 5-hydroxytryptamine receptor 1A Rattus norvegicus 40-46 7993956-3 1994 Ipsapirone increased oxytocin, adrenocorticotropic hormone (ACTH), corticosterone, and prolactin, but not renin or vasopressin concentrations in plasma. ipsapirone 0-10 proopiomelanocortin Homo sapiens 31-58 7993956-3 1994 Ipsapirone increased oxytocin, adrenocorticotropic hormone (ACTH), corticosterone, and prolactin, but not renin or vasopressin concentrations in plasma. ipsapirone 0-10 proopiomelanocortin Homo sapiens 60-64 7993956-4 1994 Chronic fluoxetine, but not DMI, significantly inhibited the effect of ipsapirone on plasma oxytocin, ACTH and corticosterone concentrations. ipsapirone 71-81 proopiomelanocortin Homo sapiens 102-106 7993956-8 1994 Finally, because ipsapirone may be administered to humans, it might be usable to evaluate 5-HT1A receptor function in depressed patients. ipsapirone 17-27 5-hydroxytryptamine receptor 1A Homo sapiens 90-105 8071858-4 1994 Systemic administration of the 5-HT1A receptor partial agonists buspirone and ipsapirone produced marked increases in ACh efflux with less pronounced motor effects, whereas 8-[2-(2,3-dihydro-1,4-benzodioxin-2-yl- methylamino)ethyl]-8-azaspiro[4,5]-decane-7,9-dione methyl sulphonate (MDL 73005) modestly increased ACh efflux with no effect on motor activity. ipsapirone 78-88 5-hydroxytryptamine receptor 1A Cavia porcellus 31-37 7838324-0 1994 The role of postsynaptic 5-HT1A receptors in the anticonflict effect of ipsapirone. ipsapirone 72-82 5-hydroxytryptamine receptor 1A Rattus norvegicus 25-31 7838324-1 1994 In the present paper we have studied the anticonflict effect (in the Vogel test) of ipsapirone, a partial agonist of 5-hydroxytryptamine1A (5-HT1A) receptors, administered to the hippocampus of rats. ipsapirone 84-94 5-hydroxytryptamine receptor 1A Rattus norvegicus 117-138 7838324-1 1994 In the present paper we have studied the anticonflict effect (in the Vogel test) of ipsapirone, a partial agonist of 5-hydroxytryptamine1A (5-HT1A) receptors, administered to the hippocampus of rats. ipsapirone 84-94 5-hydroxytryptamine receptor 1A Rattus norvegicus 140-146 7838324-17 1994 Our results seem to indicate that the anticonflict effect of ipsapirone stems from stimulation of postsynaptic 5-HT1A receptors in the hippocampus. ipsapirone 61-71 5-hydroxytryptamine receptor 1A Rattus norvegicus 111-117 7969811-2 1994 Selective 5-HT1A agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), flesinoxan, buspirone and ipsapirone significantly decreased the power value of 7-9 Hz band activity and the median frequency of wr-RSA. ipsapirone 105-115 5-hydroxytryptamine receptor 1A Rattus norvegicus 10-16 7915845-3 1994 Ipsapirone is a novel anxiolytic azapirone which has high specificity for the 5-HT1A receptor and which has the potential for offering certain advantages over buspirone. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Homo sapiens 78-93 8155646-4 1994 The concentration of agonist producing half-maximal binding of [32P]-AA-GTP by G(i)alpha-3 [5-HT, 48 +/- 1 nM; 8-OH-DPAT, 28 +/- 1 nM; ipsapirone, 22 +/- 6 nM] compared to G(i)alpha-2 [5-HT, 124 +/- 38 nM; 8-OH-DPAT, 40 +/- 1 nM, ipsapirone, 82 +/- 7 nM] was lower with all agonists except rauwolscine, where the EC50"s were similar (G(i)alpha-2, 604 +/- 145 nM; Gi alpha-3, 708 +/- 130 nM). ipsapirone 135-145 G protein subunit alpha i3 Homo sapiens 79-90 8155646-4 1994 The concentration of agonist producing half-maximal binding of [32P]-AA-GTP by G(i)alpha-3 [5-HT, 48 +/- 1 nM; 8-OH-DPAT, 28 +/- 1 nM; ipsapirone, 22 +/- 6 nM] compared to G(i)alpha-2 [5-HT, 124 +/- 38 nM; 8-OH-DPAT, 40 +/- 1 nM, ipsapirone, 82 +/- 7 nM] was lower with all agonists except rauwolscine, where the EC50"s were similar (G(i)alpha-2, 604 +/- 145 nM; Gi alpha-3, 708 +/- 130 nM). ipsapirone 230-240 G protein subunit alpha i3 Homo sapiens 79-90 8011800-1 1994 The cortisol response to ipsapirone (a 5-HT1A-partial agonist that produces a dose-dependent increase in plasma cortisol secretion in man) is blunted in major depression. ipsapirone 25-35 5-hydroxytryptamine receptor 1A Homo sapiens 39-45 7984279-2 1994 In the anaesthetized rat, administration of the 5-HT1A agonists buspirone, gepirone and ipsapirone increased noradrenaline levels in the microdialysates. ipsapirone 88-98 5-hydroxytryptamine receptor 1A Rattus norvegicus 48-54 8041492-3 1994 Postnatal treatment with ipsapirone, a 5-HT1A agonist, shown to stimulate glial release of S-100, alleviated the cellular disruptions and growth retardation caused by prenatal cocaine exposure. ipsapirone 25-35 5-hydroxytryptamine receptor 1A Homo sapiens 39-45 8041492-3 1994 Postnatal treatment with ipsapirone, a 5-HT1A agonist, shown to stimulate glial release of S-100, alleviated the cellular disruptions and growth retardation caused by prenatal cocaine exposure. ipsapirone 25-35 S100 calcium binding protein B Homo sapiens 91-96 7846206-9 1994 Disruption of the IRT distribution by buspirone, gepirone, ipsapirone and zalospirone may result from decreased 5-HT transmission mediated by the presynaptic, somatodendritic 5-HT1A receptor. ipsapirone 59-69 5-hydroxytryptamine receptor 1A Homo sapiens 175-190 8138956-12 1994 They also suggest that the inhibitory influence of systemically administered direct 5-HT1A agonists such as 8-OH-DPAT and ipsapirone on the electrical and metabolic activity of serotoninergic neurons does not result solely from the stimulation of somatodendritic 5-HT1A autoreceptors. ipsapirone 122-132 5-hydroxytryptamine receptor 1A Rattus norvegicus 84-90 8138956-12 1994 They also suggest that the inhibitory influence of systemically administered direct 5-HT1A agonists such as 8-OH-DPAT and ipsapirone on the electrical and metabolic activity of serotoninergic neurons does not result solely from the stimulation of somatodendritic 5-HT1A autoreceptors. ipsapirone 122-132 5-hydroxytryptamine receptor 1A Rattus norvegicus 263-269 7846198-1 1994 A dose-response study of ipsapirone (IPS), a 5HT1a partial agonist, was conducted in healthy male subjects. ipsapirone 25-35 5-hydroxytryptamine receptor 1A Homo sapiens 45-50 7846198-5 1994 Although IPS increased ACTH levels at 20 mg, this effect was variable and not significant. ipsapirone 9-12 proopiomelanocortin Homo sapiens 23-27 7846198-8 1994 IPS at 20 mg PO appears a useful probe to test 5HT1a function when temperature and cortisol are used as response variables. ipsapirone 0-3 5-hydroxytryptamine receptor 1A Homo sapiens 47-52 7903326-1 1993 Ipsapirone is a partial 5-HT1A agonist which appears promising for the pharmacologic treatment of anxiety. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Homo sapiens 24-30 7904566-1 1993 In rats, the 5-HT1A receptor full agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and the 5-HT1A receptor partial agonists ipsapirone and buspirone dose dependently and completely inhibited shock-induced ultrasonic vocalization after systemic injection and after microinjection into the dorsal raphe nucleus, a brain region rich in somatodendritic 5-HT1A receptors. ipsapirone 134-144 5-hydroxytryptamine receptor 1A Rattus norvegicus 101-107 7904566-1 1993 In rats, the 5-HT1A receptor full agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and the 5-HT1A receptor partial agonists ipsapirone and buspirone dose dependently and completely inhibited shock-induced ultrasonic vocalization after systemic injection and after microinjection into the dorsal raphe nucleus, a brain region rich in somatodendritic 5-HT1A receptors. ipsapirone 134-144 5-hydroxytryptamine receptor 1A Rattus norvegicus 101-107 7904566-8 1993 It is suggested that both presynaptic and (possibly to a lesser extent) postsynaptic 5-HT1A receptors are involved in the anxiolytic effects of ipsapirone, buspirone, and 8-OH-DPAT. ipsapirone 144-154 5-hydroxytryptamine receptor 1A Rattus norvegicus 85-91 11224231-0 1993 Neuroanatomical basis for the antidepressant-like effects of the 5-HT(1A) receptor agonists 8-OH-DPAT and ipsapirone in the rat forced swimming test. ipsapirone 106-116 5-hydroxytryptamine receptor 1A Rattus norvegicus 65-72 11224231-4 1993 Systemic application of the 5-HT(1A) receptor partial agonist ipsapirone resulted in a U-shaped dose-response curve (maximal effect about 30% immobility reduction at 3-10mg/kg). ipsapirone 62-72 5-hydroxytryptamine receptor 1A Rattus norvegicus 28-35 7904048-5 1993 Acute administration of the 5-HT1A receptor agonists buspirone (0.1-5 mg/kg s.c.) and ipsapirone (0.03-3 mg/kg s.c.) caused a dose-dependent decrease in 5-HT output in ventral hippocampus of the chloral hydrate anaesthetized rat. ipsapirone 86-96 5-hydroxytryptamine receptor 1A Rattus norvegicus 28-34 8106004-0 1993 Antidepressant/anxiolytic ipsapirone inhibits cold-induced hypothalamic TRH release. ipsapirone 26-36 thyrotropin releasing hormone Homo sapiens 72-75 8106004-2 1993 Therefore, the aim of the present study was to evaluate, by means of a push-pull cannula implanted in the median eminence (ME), whether ipsapirone acts primarily through an inhibition of cold-elicited thyrotropin-releasing hormone (TRH) release. ipsapirone 136-146 thyrotropin releasing hormone Homo sapiens 201-230 8106004-3 1993 Ipsapirone administration (10 mg kg-1 i.p., 30 min before cold) prevented cold-elicited TRH release, thereby confirming the above hypothesis. ipsapirone 0-10 thyrotropin releasing hormone Homo sapiens 88-91 7903873-4 1993 It is suggested that camphorimide analogues are the 5-HT3 receptor blockers while busperone and ipsapirone modulate 5-HT3 receptor affinity by decreasing the protein kinase A activity. ipsapirone 96-106 5-hydroxytryptamine receptor 3A Rattus norvegicus 116-130 7691626-0 1993 Anxiolytic effects of the 5-HT1A receptor agonist ipsapirone in the rat: neurobiological correlates. ipsapirone 50-60 5-hydroxytryptamine receptor 1A Rattus norvegicus 26-32 7691626-1 1993 Ipsapirone, a 5-HT1A receptor agonist, is a psychoactive compound with anxiolytic and antidepressive properties. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 14-20 7691626-9 1993 It is concluded that ipsapirone exhibits its anxiolytic effects, at least partially, by stimulating presynaptic somatodendritic 5-HT1A receptors in the brain stem raphe nuclei (i.e., the dorsal raphe), resulting in attenuation of presynaptic cell firing and subsequent inhibition of serotonergic neurotransmission in the limbic system (i.e., the hippocampus). ipsapirone 21-31 5-hydroxytryptamine receptor 1A Rattus norvegicus 128-134 8274843-7 1993 Specifically, alpha 1A-adrenergic receptors seem to be involved in ipsapirone vascular effects, since this agent selectively relaxed aortic preparation precontracted with methoxamine and unlike chloroethylclonidine, clearly inhibited the contractile effect of this agonist. ipsapirone 67-77 calcium voltage-gated channel subunit alpha1 A Homo sapiens 14-22 8248853-3 1993 Pharmacol., 37:231-237] have shown that a large receptor reserve exists for the inhibition of serotonin synthesis in rat cortex and hippocampus by the 5-HT1A agonist 8-hydroxy-2(di-n-propylamino)tetralin (8-OH-DPAT), whereas little or no reserve exists for the lower efficacy agonists ipsapirone and BMY 7378. ipsapirone 285-295 5-hydroxytryptamine receptor 1A Rattus norvegicus 151-157 8274843-8 1993 In summary, the present findings can be explained by accepting that ipsapirone may act as an antagonist at alpha 1A-adrenoceptors. ipsapirone 68-78 calcium voltage-gated channel subunit alpha1 A Homo sapiens 107-115 8336817-0 1993 Comparative effects of chronic 8-OH-DPAT, gepirone and ipsapirone treatment on the sensitivity of somatodendritic 5-HT1A autoreceptors. ipsapirone 55-65 5-hydroxytryptamine receptor 1A Rattus norvegicus 114-120 11224195-4 1993 Drugs with affinity for 5-HT(1A) receptors (i.e. 8-OHDPAT, flesinoxan, ipsapirone, buspirone, gepirone, NAN-190) abolished the vocalization irrespective of their efficacy. ipsapirone 71-81 5-hydroxytryptamine receptor 1A Rattus norvegicus 24-31 10607079-0 1993 Effects of ipsapirone, a 5-HT1A agonist, on sleep/wakefulness cycles: probable post-synaptic action. ipsapirone 11-21 5-hydroxytryptamine receptor 1A Rattus norvegicus 25-31 10607079-1 1993 The effects of ipsapirone, a ligand of the 5-HT1A receptors and a new potential anxiolytic, on sleep/wakefulness regulation were examined in the rat. ipsapirone 15-25 5-hydroxytryptamine receptor 1A Rattus norvegicus 43-49 10607079-6 1993 Thus, the action of the 5-HT1A agonist ipsapirone on sleep/wakefulness cycles probably involves the stimulation of the post-synaptic 5-HT1A receptors. ipsapirone 39-49 5-hydroxytryptamine receptor 1A Rattus norvegicus 24-30 10607079-6 1993 Thus, the action of the 5-HT1A agonist ipsapirone on sleep/wakefulness cycles probably involves the stimulation of the post-synaptic 5-HT1A receptors. ipsapirone 39-49 5-hydroxytryptamine receptor 1A Rattus norvegicus 133-139 8336817-5 1993 The present results are consistent with the suggestion that the clinical anxiolytic effects of gepirone and ipsapirone, and not of 8-OH-DPAT, may be related to their ability to desensitize somatodendritic 5-HT1A autoreceptors; other potential mechanisms are discussed. ipsapirone 108-118 5-hydroxytryptamine receptor 1A Rattus norvegicus 205-211 7693136-1 1993 Intrastriatal administration of ipsapirone (IPSA, 0.5 and 1 mM), an agonist of 5-HT1A serotonergic receptors, enhanced in a dose-dependent manner DA release in the rat striatum, without affecting levels of the DA metabolites DOPAC and HVA. ipsapirone 32-42 5-hydroxytryptamine receptor 1A Rattus norvegicus 79-85 8507391-2 1993 Systemic administration of the 5-HT1A agonist ipsapirone (1.25-5.0 mg/kg) caused a dose-dependent decrease in ethanol preference and intake, while the 5-HT2 antagonist ritanserin (1.25-5.0 mg/kg) and the 5-HT3 antagonists ondansetron (0.01-1.0 mg/kg) and granisetron (0.5-1.0 mg/kg) failed to alter ethanol consumption. ipsapirone 46-56 5-hydroxytryptamine receptor 3A Rattus norvegicus 204-209 8507391-2 1993 Systemic administration of the 5-HT1A agonist ipsapirone (1.25-5.0 mg/kg) caused a dose-dependent decrease in ethanol preference and intake, while the 5-HT2 antagonist ritanserin (1.25-5.0 mg/kg) and the 5-HT3 antagonists ondansetron (0.01-1.0 mg/kg) and granisetron (0.5-1.0 mg/kg) failed to alter ethanol consumption. ipsapirone 46-56 5-hydroxytryptamine receptor 1A Rattus norvegicus 31-37 7686527-9 1993 The benzodiazepine diazepam (1mg/kg) and the selective 5-HT1A agonist ipsapirone (0.5-10mg/kg) significantly reduced freezing. ipsapirone 70-80 5-hydroxytryptamine receptor 1A Rattus norvegicus 55-61 7686527-12 1993 In conclusion, these results suggest that the anxiolytic effect of ipsapirone results from the activation of postsynaptic 5-HT1A receptors and the facilitation of 5-HT neurotransmission decreases anxiety. ipsapirone 67-77 5-hydroxytryptamine receptor 1A Rattus norvegicus 122-128 8496807-4 1993 The selective 5-HT1A receptor agonist ipsapirone substituted completely for 8-OH-DPAT (ED50, 1.52 mg/kg) and 5-OMe-DMT substituted partially for 8-OH-DPAT, whereas 8-OH-DPAT (ED50, 0.07 mg/kg) and ipsapirone (ED50, 4.15 mg/kg) substituted completely for 5-OMe-DMT. ipsapirone 38-48 5-hydroxytryptamine receptor 1A Rattus norvegicus 14-20 8496807-4 1993 The selective 5-HT1A receptor agonist ipsapirone substituted completely for 8-OH-DPAT (ED50, 1.52 mg/kg) and 5-OMe-DMT substituted partially for 8-OH-DPAT, whereas 8-OH-DPAT (ED50, 0.07 mg/kg) and ipsapirone (ED50, 4.15 mg/kg) substituted completely for 5-OMe-DMT. ipsapirone 197-207 5-hydroxytryptamine receptor 1A Rattus norvegicus 14-20 7686633-7 1993 ), (-)tertatolol prevented the inhibitory effects of the 5-HT1A receptor agonists 8-OH-DPAT, ipsapirone and lesopitron on the firing rate of serotoninergic neurones within the dorsal raphe nucleus. ipsapirone 93-103 5-hydroxytryptamine receptor 1A Rattus norvegicus 57-63 7693136-3 1993 The effects of intrastriatal administration of IPSA were mimicked by 8-OH-DPAT (0.5 mM), another agonist of 5-HT1A receptors, and were antagonized by the peripheral administration of metergoline (5 mg/kg ip) and intrastriatal administration of NAN-190 (0.5 mM). ipsapirone 47-51 5-hydroxytryptamine receptor 1A Rattus norvegicus 108-114 7693136-5 1993 It is postulated that IPSA increases the release of DA from nigrostriatal terminals via activation of striatal 5-HT1A receptors in a manner independent of the activation of 5-HT1A receptors in the dorsal raphe nuclei. ipsapirone 22-26 5-hydroxytryptamine receptor 1A Rattus norvegicus 111-117 7693136-1 1993 Intrastriatal administration of ipsapirone (IPSA, 0.5 and 1 mM), an agonist of 5-HT1A serotonergic receptors, enhanced in a dose-dependent manner DA release in the rat striatum, without affecting levels of the DA metabolites DOPAC and HVA. ipsapirone 44-48 5-hydroxytryptamine receptor 1A Rattus norvegicus 79-85 7690117-0 1993 Are 5-HT1A autoreceptors involved in the inhibitory effect of ipsapirone on cold-elicited thyrotropin secretion? ipsapirone 62-72 5-hydroxytryptamine receptor 1A Rattus norvegicus 4-10 7690117-1 1993 Administration of the serotonin (5-HT)1A receptor agonist ipsapirone has been shown to decrease cold-elicited thyrotropin (TSH) secretion. ipsapirone 58-68 5-hydroxytryptamine receptor 1A Rattus norvegicus 22-49 7690117-7 1993 These results suggest that presynaptic 5-HT1A receptors mediate ipsapirone-induced inhibition of cold-elicited TSH release, an effect which may be partially opposed by postsynaptic 5-HT1A receptor stimulation. ipsapirone 64-74 5-hydroxytryptamine receptor 1A Rattus norvegicus 39-45 7690117-7 1993 These results suggest that presynaptic 5-HT1A receptors mediate ipsapirone-induced inhibition of cold-elicited TSH release, an effect which may be partially opposed by postsynaptic 5-HT1A receptor stimulation. ipsapirone 64-74 5-hydroxytryptamine receptor 1A Rattus norvegicus 181-187 8095465-2 1993 In this study, we tested the influence of repeated treatment with the 5-HT1A receptor agonist ipsapirone (0.5 g/l in drinking water for 21 days) on some 5-HT2 receptor-mediated responses elicited by the acute injection of the 5-HT1C/5-HT2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). ipsapirone 94-104 5-hydroxytryptamine receptor 1A Rattus norvegicus 70-76 8467355-6 1993 Other selective 5-HT1A receptor ligands (0.3-30 mg kg-1, s.c.) either mimicked the 8-OH-DPAT response (ipsapirone, at 10 and 30 mg kg-1, s.c.) or were inactive (buspirone and gepirone). ipsapirone 103-113 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 16-31 8095465-12 1993 These data indicate that a 3-week treatment with anxiolytic doses of the 5-HT1A receptor agonist ipsapirone does not desensitize 5-HT2 receptors. ipsapirone 97-107 5-hydroxytryptamine receptor 1A Rattus norvegicus 73-79 8095465-0 1993 Subchronic treatment with anxiolytic doses of the 5-HT1A receptor agonist ipsapirone does not affect 5-HT2 receptor sensitivity in the rat. ipsapirone 74-84 5-hydroxytryptamine receptor 1A Rattus norvegicus 50-56 8445996-1 1993 5-HT-1A receptor agonists suppress the rat hind paw licking reaction on a hot-plate and unpunished drinking in thirsty rats with the order of potency: 8-OH-DPAT > Ru 24.969 > buspirone > gepirone > ipsapirone. ipsapirone 210-220 5-hydroxytryptamine receptor 1A Rattus norvegicus 0-7 7870936-7 1993 Buspirone (0.01-10 mg/kg), a 5HT1A partial agonist, also attenuated the discriminative stimulus effects of the training dose of U50,488 but ipsapirone, another 5HT1A partial agonist, did not. ipsapirone 140-150 5-hydroxytryptamine receptor 1A Homo sapiens 160-165 8378408-4 1993 Available 5-HT1a agonists (buspirone, gepirone, ipsapirone) are somewhat disappointing as anxiolytics but more specific compounds (flesinoxan, S 20499, E 4424) are now in development. ipsapirone 48-58 5-hydroxytryptamine receptor 1A Homo sapiens 10-16 7871009-5 1993 The relatively full 5-HT1A agonist, flesinoxan, and the partial 5-HT1A agonist, ipsapirone, had qualitatively similar effects to 8-OH-DPAT, although the effect of ipsapirone was clearly smaller in magnitude. ipsapirone 80-90 5-hydroxytryptamine receptor 1A Rattus norvegicus 64-70 7870899-3 1993 5-HT1A agonists (BAY R 1531, 8-OHDPAT, flesinoxan, gepirone, 5MeO DMT, buspirone, ipsapirone, BMY 14802) completely inhibit the aggressive behaviour irrespective of their intrinsic activities. ipsapirone 82-92 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 0-6 7870997-0 1993 Ipsapirone and 8-OH-DPAT reduce ethanol preference in rats: involvement of presynaptic 5-HT1A receptors. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 87-93 1407392-7 1992 At a larger concentration (10 microM), the latter compound reduced the neuronal discharge probably through the stimulation of somatodendritic 5-HT1A autoreceptors since this effect, as that of ipsapirone, could be prevented by 10 microM l-propranolol. ipsapirone 193-203 5-hydroxytryptamine receptor 1A Rattus norvegicus 142-148 7870997-7 1993 The preference reducing effect of ipsapirone (20 mg/kg, PO) was completely blocked by the nonselective 5-HT1A antagonist spiperone (0.05 mg/kg, SC). ipsapirone 34-44 5-hydroxytryptamine receptor 1A Rattus norvegicus 103-109 1360535-0 1992 Stimulation of postsynaptic 5-HT1A receptors is responsible for the anticonflict effect of ipsapirone in rats. ipsapirone 91-101 5-hydroxytryptamine receptor 1A Rattus norvegicus 28-34 1360535-1 1992 Ipsapirone (1.25-10 mg kg-1), a non-benzodiazepine anxiolytic drug with high affinity for 5-hydroxytryptamine1A (5-HT1A) receptors, increased dose-dependently the number of punished licks in the drinking conflict test (Vogel test) in rats. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 90-111 1360535-1 1992 Ipsapirone (1.25-10 mg kg-1), a non-benzodiazepine anxiolytic drug with high affinity for 5-hydroxytryptamine1A (5-HT1A) receptors, increased dose-dependently the number of punished licks in the drinking conflict test (Vogel test) in rats. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 113-119 1360535-3 1992 The anticonflict effect of ipsapirone in PCA-pretreated rats was antagonized by the 5-HT1A receptor and alpha 1-adrenoceptor antagonist NAN-190 (1-(2-methoxyphenyl)-4-[4-(2-phthalimmido)]butylpiperazine hydrobromide; 0.5-1 mg kg-1), but not by the selective alpha 1-adrenoceptor blocker prazosin (0.5 mg kg-1). ipsapirone 27-37 5-hydroxytryptamine receptor 1A Rattus norvegicus 84-90 1360535-5 1992 The present results indicate that the anticonflict effect of ipsapirone depends on stimulation of postsynaptic 5-HT1A receptors. ipsapirone 61-71 5-hydroxytryptamine receptor 1A Rattus norvegicus 111-117 1355919-5 1992 The 5-HT1A agonist ipsapirone, with anxiolytic properties, dose-dependently (0.5 and 2.5 mg/kg, IV) reduced defensive burying behavior and increased the amount of time spent on feeding behavior in the presence of bedding material. ipsapirone 19-29 5-hydroxytryptamine receptor 1A Rattus norvegicus 4-10 1355919-6 1992 Both plasma E and CORT levels were further elevated by the higher dose of ipsapirone. ipsapirone 74-84 cortistatin Rattus norvegicus 18-22 1355919-7 1992 In the absence of bedding material, ipsapirone failed to affect immobility behavior, but it dose-dependently elevated the stress-induced increase in E, NE, and CORT concentrations. ipsapirone 36-46 cortistatin Rattus norvegicus 160-164 1355919-8 1992 Accordingly, the behavioral anxiolytic action of the 5-HT1A agonist ipsapirone was restricted to active coping, whereas neuroendocrine activation by the drug was present in all conditions. ipsapirone 68-78 5-hydroxytryptamine receptor 1A Rattus norvegicus 53-59 1355919-9 1992 It is suggested that the effects of ipsapirone on behavioral coping and neuroendocrine regulation are produced by different populations of 5-HT1A receptors in the brain. ipsapirone 36-46 5-hydroxytryptamine receptor 1A Rattus norvegicus 139-145 1353629-1 1992 The present study was designed to investigate the effects of the anxiolytic 5-HT1A receptor agonist ipsapirone on the hormonal responses in rats under nonstress and stress conditions by means of repeated blood sampling through an intracardiac catheter. ipsapirone 100-110 5-hydroxytryptamine receptor 1A Rattus norvegicus 76-82 1353629-7 1992 Rats receiving an inescapable footshock 1 day earlier showed a further elevated corticosterone response to the 5-HT1A receptor agonist ipsapirone even before exposing them to the conditioned stress situation. ipsapirone 135-145 5-hydroxytryptamine receptor 1A Rattus norvegicus 111-117 7903466-0 1993 Chronic treatment with an anxiolytic dose of the 5-HT1A agonist ipsapirone does not alter ipsapirone acute neuroendocrine effects. ipsapirone 64-74 5-hydroxytryptamine receptor 1A Rattus norvegicus 49-55 7903466-1 1993 We recently reported that chronic administration of the 5-HT1A receptor agonist, ipsapirone (0.5 milligrams in drinking water for 3 weeks), has anxiolytic activity in the rat. ipsapirone 81-91 5-hydroxytryptamine receptor 1A Rattus norvegicus 56-62 1359439-13 1992 Ipsapirone potentiated the effect of DOI on the concentration of renin in plasma but this effect was not observed in 8-OH-DPAT- and buspirone-pretreated rats. ipsapirone 0-10 renin Rattus norvegicus 65-70 1446239-10 1992 Iontophoretic application of the 5HT1A agonists, 8-OH-DPAT and ipsapirone, mimic the suppressive action of serotonin in a dose-dependent manner. ipsapirone 63-73 5-hydroxytryptamine receptor 1A Homo sapiens 33-38 1422568-4 1992 The 5-HT1A receptor partial agonists, buspirone, gepirone and ipsapirone, also dose-dependently induced hypothermia. ipsapirone 62-72 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 4-19 1496123-5 1992 These include fenfluramine-induced changes in ACTH, cortisol and prolactin secretion (perhaps for 5HT2 receptors) and ipsapirone-induced changes in ACTH and cortisol (for 5HT1A receptors). ipsapirone 118-128 proopiomelanocortin Homo sapiens 148-152 1357765-0 1992 Alteration of 5-HT1A receptor binding sites following chronic treatment with ipsapirone measured by quantitative autoradiography. ipsapirone 77-87 5-hydroxytryptamine receptor 1A Rattus norvegicus 14-20 1357765-1 1992 Ipsapirone, a high-affinity ligand for the 5-hydroxytryptamine1A (5-HT1A) receptor subtype, has been shown to be a full agonist at presynaptic serotonergic sites and a partial agonist at postsynaptic sites. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 43-64 1357765-1 1992 Ipsapirone, a high-affinity ligand for the 5-hydroxytryptamine1A (5-HT1A) receptor subtype, has been shown to be a full agonist at presynaptic serotonergic sites and a partial agonist at postsynaptic sites. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 66-72 1357765-2 1992 Several recent studies have examined the effects of chronic treatment with ipsapirone or other structurally related pyrimidinylpiperazine compounds, including buspirone and gepirone, on 5-HT1A binding sites with mixed results. ipsapirone 75-85 5-hydroxytryptamine receptor 1A Rattus norvegicus 186-192 1357765-5 1992 Experiments were performed to determine whether chronic treatment with ipsapirone would differentially affect binding to 5-HT1A receptors at different brain sites. ipsapirone 71-81 5-hydroxytryptamine receptor 1A Rattus norvegicus 121-127 11224126-1 1992 The synergistic effect between the 5-HT(1A) agonist ipsapirone and the calcium channel antagonist, nifedipine, was studied in animal models of anxiety and depression. ipsapirone 52-62 5-hydroxytryptamine receptor 1A Homo sapiens 35-42 1352034-2 1992 5-HT1A agonists with anxiolytic properties (e.g., buspirone, gepirone, and ipsapirone) display full intrinsic activity at these receptors but are partial agonists at postsynaptic 5-HT1A receptors, which suggests that the latter sites may be devoid of a receptor reserve. ipsapirone 75-85 5-hydroxytryptamine receptor 1A Rattus norvegicus 0-6 1352034-2 1992 5-HT1A agonists with anxiolytic properties (e.g., buspirone, gepirone, and ipsapirone) display full intrinsic activity at these receptors but are partial agonists at postsynaptic 5-HT1A receptors, which suggests that the latter sites may be devoid of a receptor reserve. ipsapirone 75-85 5-hydroxytryptamine receptor 1A Rattus norvegicus 179-185 1354556-0 1992 Comparison of neuroendocrine and behavioral effects of ipsapirone, a 5-HT1A agonist, in three stress paradigms: immobilization, forced swim and conditioned fear. ipsapirone 55-65 5-hydroxytryptamine receptor 1A Rattus norvegicus 69-75 1354556-1 1992 Ipsapirone is an anxiolytic drug and a serotonin1A (5-HT1A) agonist. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 52-58 1354556-10 1992 However, the ACTH response to CER was significantly (P less than 0.01) inhibited by all doses of ipsapirone and the highest dose of ipsapirone attenuated the renin response. ipsapirone 132-142 renin Rattus norvegicus 158-163 1354556-16 1992 Of the hormones studied, the stimulation of renin secretion after exposure to the three stressors was most sensitive to ipsapirone, while corticosterone and prolactin were the least sensitive to ipsapirone. ipsapirone 120-130 renin Rattus norvegicus 44-49 1353126-2 1992 The aim of this study is to examine the effect of ipsapirone, which is a specific 5-HT1A agonist with a pyrimidinylpiperazine structure, on alcohol consumption in mice (C57BL/6J) by a voluntary alcohol intake paradigm. ipsapirone 50-60 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 82-88 1374260-2 1992 The voltammetric DOPAC signal in the Locus coeruleus, used as a measure of NE neuronal activity, was increased after systemic application of the 5-HT1B agonist CGS-12066B, the 5-HT2 antagonist ritanserin, and, to a lesser extent, by ipsapirone, a 5-HT1A agonist. ipsapirone 233-243 5-hydroxytryptamine receptor 1B Rattus norvegicus 145-151 1355572-8 1992 The new anxiolytic ipsapirone, a selective 5-HT1A agonist, also reduced the freezing response. ipsapirone 19-29 5-hydroxytryptamine receptor 1A Rattus norvegicus 43-49 1346719-1 1992 To explore 5-HT1A receptor responsivity in panic disorder (PD), hypothermic, neuroendocrine and behavioral responses to the selective partial 5-HT1A receptor agonist ipsapirone (IPS) were investigated in patients with primary PD and healthy controls. ipsapirone 166-176 5-hydroxytryptamine receptor 1A Homo sapiens 11-26 1346719-3 1992 IPS induced hypothermia and corticotropin (ACTH)/cortisol release but had only minimal effects on behavior. ipsapirone 0-3 proopiomelanocortin Homo sapiens 43-47 1687762-4 1991 The benzodiazepine, diazepam; the 5-HT1A agent, ipsapirone; and the 5-HT3 receptor antagonist, ondansetron, produced significant anxiolytic-like activity between doses of 1.0 to 10.0 mg/kg, 17.8 to 31.6 mg/kg, and 0.0001 to 1.0 mg/kg respectively. ipsapirone 48-58 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 34-40 1513929-6 1992 The 5-HT1A agonists buspirone, ipsapirone and 8-OH-DPAT decreased aggression in RI and MA, but simultaneously led to a marked decrease in social interest and activity, indicative of a non-specific anti-aggressive profile. ipsapirone 31-41 5-hydroxytryptamine receptor 1A Canis lupus familiaris 4-10 1410132-2 1992 In the spinal withdrawal reflex test, administration of the selective 5-HT1A agonists ipsapirone, gepirone and PAPP resulted in significant dose-dependent increases in receptive field (RF) area for withdrawal reflexes when compared to predrug baseline values, indicating an increase in nociceptive sensitivity. ipsapirone 86-96 5-hydroxytryptamine receptor 1A Homo sapiens 70-76 1410132-5 1992 In the tail-flick analgesiometric test, administration of the 5-HT1A agonists 8-OH-DPAT and ipsapirone and the 5-HT1B agonists RU24969 and mCPP resulted in a significant dose-dependent increase in tail-flick latencies when compared to predrug baseline values, indicating a decrease in nociceptive sensitivity to noxious thermal stimuli. ipsapirone 92-102 5-hydroxytryptamine receptor 1A Homo sapiens 62-68 1681447-2 1991 1-(2-Pyrimidinyl)-piperazine (1-PP) is a common metabolite of the antidepressant/anxiolytic 5-HT1A agonists, tandospirone (SM-3997), gepirone, buspirone and ipsapirone. ipsapirone 157-167 5-hydroxytryptamine receptor 1A Rattus norvegicus 92-98 1682325-8 1991 The potency of 8-OH-DPAT, flesinoxan, ipsapirone, sumatriptan and phentolamine, at decreasing phenylephrine-induced tone in the mesentery correlated closely with antagonist potency at alpha 1-adrenoceptors (r = 0.99) but not with affinity at 5-HT1A binding sites (r = -0.2). ipsapirone 38-48 5-hydroxytryptamine receptor 1A Rattus norvegicus 242-248 11224077-6 1991 Other drugs with high affinity for 5-HT(1A) receptors, such as the azapirones gepirone, ipsapirone and buspirone, produced selective reductions of saccharin preference in rats trained to discriminate 8-OH-DPAT from saline but not in controls. ipsapirone 88-98 5-hydroxytryptamine receptor 1A Rattus norvegicus 35-42 1681448-0 1991 Evidence for the involvement of 5-HT1A receptors in the anticonflict effect of ipsapirone in rats. ipsapirone 79-89 5-hydroxytryptamine receptor 1A Rattus norvegicus 32-38 1681448-1 1991 The anticonflict activity of ipsapirone, a non-benzodiazepine anxiolytic drug, with high affinity for 5-hydroxytryptamine1A (5-HT1A) receptors, was studied in the drinking conflict test in the rat. ipsapirone 29-39 5-hydroxytryptamine receptor 1A Rattus norvegicus 102-123 1681448-1 1991 The anticonflict activity of ipsapirone, a non-benzodiazepine anxiolytic drug, with high affinity for 5-hydroxytryptamine1A (5-HT1A) receptors, was studied in the drinking conflict test in the rat. ipsapirone 29-39 5-hydroxytryptamine receptor 1A Rattus norvegicus 125-131 1681448-3 1991 The anticonflict effect of ipsapirone (5 mg/kg) was dose-dependently antagonized by the 5-HT1A receptor, alpha 1-adrenoceptor and dopamine receptor antagonist, NAN-190 (0.25-1 mg/kg) and by the beta-adrenoceptor blocker, SDZ 21009, which also has a high affinity for 5-HT1A and 5-HT1B receptors (2-8 mg/kg). ipsapirone 27-37 5-hydroxytryptamine receptor 1A Rattus norvegicus 88-94 1681448-3 1991 The anticonflict effect of ipsapirone (5 mg/kg) was dose-dependently antagonized by the 5-HT1A receptor, alpha 1-adrenoceptor and dopamine receptor antagonist, NAN-190 (0.25-1 mg/kg) and by the beta-adrenoceptor blocker, SDZ 21009, which also has a high affinity for 5-HT1A and 5-HT1B receptors (2-8 mg/kg). ipsapirone 27-37 5-hydroxytryptamine receptor 1A Rattus norvegicus 267-273 1681448-6 1991 These results suggest that the anticonflict effect of ipsapirone in the Vogel test, results from its interaction with 5-HT1A receptors, which are probably located postsynaptically. ipsapirone 54-64 5-hydroxytryptamine receptor 1A Rattus norvegicus 118-124 1678895-1 1991 The 5-HT1A agonists buspirone, gepirone and ipsapirone have been shown to possess antidepressive-like properties in several animal models of depression as well as in clinical studies. ipsapirone 44-54 5-hydroxytryptamine receptor 1A Rattus norvegicus 4-10 1679740-0 1991 [Behavioral pharmacological and electroencephalographic effects of the 5-HT1A partial agonist ipsapirone]. ipsapirone 94-104 5-hydroxytryptamine receptor 1A Rattus norvegicus 71-77 1679740-1 1991 The behavioral and EEG effects of the 5-HT1A partial agonist ipsapirone were investigated to determine its pharmacological characteristics as an anxiolytic drug in rats, mice and rabbits, as compared with those of buspirone and diazepam. ipsapirone 61-71 5-hydroxytryptamine receptor 1A Rattus norvegicus 38-44 1675288-7 1991 Hyperlocomotion and head weaving induced by CGP 37849 in kindled rats could be attenuated or totally prevented by pretreatment with ipsapirone, a partial agonist/antagonist at postsynaptic 5-hydroxytryptamine (5-HT) receptors of the 5-HT1A subtype. ipsapirone 132-142 5-hydroxytryptamine receptor 1A Rattus norvegicus 233-239 1702155-1 1990 Inasmuch as sustained treatment with the 5-hydroxytryptamine1A (5-HT1A) agonist, ipsapirone, is necessary for inducing anxiolytic and antidepressant effects in the clinic, investigations were performed for assessing the possible changes in serotoninergic and dopaminergic neurotransmission in the brain of rats 24 hr after a 2-week treatment with this drug. ipsapirone 81-91 5-hydroxytryptamine receptor 1A Rattus norvegicus 41-62 1686817-4 1991 The ability of IPS to induce hypothermia and ACTH/cortisol release was significantly attenuated during chronic FLX as compared to the pretreatment IPS challenge. ipsapirone 15-18 proopiomelanocortin Homo sapiens 45-49 1981046-9 1990 The presence of high corticosterone levels in the home cage after postdefeat ipsapirone treatment leads to the hypothesis that postsynaptic 5-HT 1A receptor hypersensitivity develops after the social stress of defeat. ipsapirone 77-87 5-hydroxytryptamine receptor 1A Rattus norvegicus 140-147 1702155-1 1990 Inasmuch as sustained treatment with the 5-hydroxytryptamine1A (5-HT1A) agonist, ipsapirone, is necessary for inducing anxiolytic and antidepressant effects in the clinic, investigations were performed for assessing the possible changes in serotoninergic and dopaminergic neurotransmission in the brain of rats 24 hr after a 2-week treatment with this drug. ipsapirone 81-91 5-hydroxytryptamine receptor 1A Rattus norvegicus 64-70 1702155-5 1990 As expected from unchanged postsynaptic 5-HT1A receptors, inhibition of forskolin-stimulated adenylate cyclase by 5-HT1A agonists (8-hydroxy-2-(di-n-propylamino)tetralin, ipsapirone) exhibited the same characteristics in hippocampal homogenates from both control and ipsapirone-treated animals. ipsapirone 171-181 5-hydroxytryptamine receptor 1A Rattus norvegicus 114-120 1702155-5 1990 As expected from unchanged postsynaptic 5-HT1A receptors, inhibition of forskolin-stimulated adenylate cyclase by 5-HT1A agonists (8-hydroxy-2-(di-n-propylamino)tetralin, ipsapirone) exhibited the same characteristics in hippocampal homogenates from both control and ipsapirone-treated animals. ipsapirone 267-277 5-hydroxytryptamine receptor 1A Rattus norvegicus 114-120 1702155-11 1990 In vitro recording of the firing of serotoninergic neurons in brain stem slices revealed a desensitization of the somatodendritic 5-HT1A receptors, which might be responsible for the increased 5-HT turnover in the brain stem and striatum of rats chronically treated with ipsapirone as compared with controls. ipsapirone 271-281 5-hydroxytryptamine receptor 1A Rattus norvegicus 130-136 2178032-3 1990 The reductions of GABA-depolarizations which were produced by 1.0 microM 5-HT were mimicked by the 5-HT1A agonists 8-OH-DPAT (8-hydroxy-2-(n-dipropylamino)tetralin) and ipsapirone. ipsapirone 169-179 5-hydroxytryptamine receptor 1A Homo sapiens 99-105 1963847-4 1990 Administration of the 5-HT1A agonists, 8-OH-DPAT (1 mg/kg) and ipsapirone (4 mg/kg), to rats resulted in activation of the HPA axis as evidenced by increased plasma ACTH and corticosterone concentrations in acutely treated rats and increased plasma corticosterone concentrations in both acutely and chronically treated rats. ipsapirone 63-73 5-hydroxytryptamine receptor 1A Rattus norvegicus 22-28 2178032-4 1990 The effects of ipsapirone were reversed by the 5-HT1A antagonist spiperone. ipsapirone 15-25 5-hydroxytryptamine receptor 1A Homo sapiens 47-53 1977479-1 1990 Evaluation of ipsapirone-induced ACTH and cortisol secretion in patients and controls. ipsapirone 14-24 proopiomelanocortin Homo sapiens 33-37 2136217-2 1990 The putative 5-HT1A receptor agonists buspirone, gepirone, ipsapirone and 8-OH-DPAT all produced anxiolytic-like effects in narrow low dose-ranges, while in higher doses the behavior returned towards that seen in controls and, after the highest doses of buspirone and gepirone, was suppressed below that of controls. ipsapirone 59-69 5-hydroxytryptamine receptor 1A Homo sapiens 13-28 1977479-2 1990 The selective 5-HT1A receptor ligand ipsapirone (IPS) induces corticotropin (ACTH) and cortisol secretion in humans. ipsapirone 37-47 5-hydroxytryptamine receptor 1A Homo sapiens 14-29 1977479-2 1990 The selective 5-HT1A receptor ligand ipsapirone (IPS) induces corticotropin (ACTH) and cortisol secretion in humans. ipsapirone 37-47 proopiomelanocortin Homo sapiens 77-81 2138459-3 1990 In contrast, both 5-HT1A agonists tested, 8-OH-DPAT and ipsapirone, produced an increase in respiratory rate at all doses tested. ipsapirone 56-66 5-hydroxytryptamine receptor 1A Rattus norvegicus 18-24 1973937-1 1990 In healthy volunteers, the azapirones--buspirone, ipsapirone, and gepirone--increase plasma cortisol and decrease body temperature; buspirone and gepirone also increase plasma prolactin and growth hormone. ipsapirone 50-60 prolactin Homo sapiens 176-185 2384138-5 1990 The results demonstrate the effectiveness of ipsapirone, thereby suggesting the involvement of 5-HT1A receptors in a conditioned anxiety situation that elicits an active coping behaviour and sympathetic activation. ipsapirone 45-55 5-hydroxytryptamine receptor 1A Rattus norvegicus 95-101 1968468-2 1990 IPS dose-dependently increased plasma ACTH concentrations from -78 +/- 63 to 614 +/- 250 pmol.min/L (P less than 0.01) and plasma cortisol concentrations from -10.8 +/- 2.9 x 10(3) to 21.3 +/- 8.2 x 10(3) nmol.min/L (P less than 0.01) at a dose of 0.3 mg/kg in six men. ipsapirone 0-3 proopiomelanocortin Homo sapiens 38-42 1968468-5 1990 The nonselective beta-adrenergic and selective 5-HT1A/1B receptor antagonist (+/-)pindolol was without effect on basal HPA activity, but completely antagonized the IPS-induced plasma ACTH and cortisol responses. ipsapirone 164-167 5-hydroxytryptamine receptor 1A Homo sapiens 47-53 1968468-5 1990 The nonselective beta-adrenergic and selective 5-HT1A/1B receptor antagonist (+/-)pindolol was without effect on basal HPA activity, but completely antagonized the IPS-induced plasma ACTH and cortisol responses. ipsapirone 164-167 proopiomelanocortin Homo sapiens 183-187 1968842-0 1990 Response of cerebellar Purkinje cells to serotonin and the 5-HT1A agonists 8-OH-DPAT and ipsapirone in vitro. ipsapirone 89-99 5-hydroxytryptamine receptor 1A Homo sapiens 59-65 1980361-1 1990 Ipsapirone, a new anxiolytic drug with a high affinity to 5-HT1A receptors, given in a dose of 10 mg/kg ip markedly accelerated noradrenaline disappearance after inhibition of tyrosine hydroxylase with alpha-methyl-p-tyrosine (250 mg/kg ip) in the cortex, hippocampus and hypothalamus of male Wistar rats. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 58-64 1980461-1 1990 The selective 5-HT1A receptor ligand ipsapirone (IPS) caused dose-related hypothermia in humans. ipsapirone 37-47 5-hydroxytryptamine receptor 1A Homo sapiens 14-29 1980461-1 1990 The selective 5-HT1A receptor ligand ipsapirone (IPS) caused dose-related hypothermia in humans. ipsapirone 49-52 5-hydroxytryptamine receptor 1A Homo sapiens 14-29 1980461-4 1990 The findings indicate that IPS-induced hypothermia specifically involves activation of (presynaptic) 5-HT1A receptors. ipsapirone 27-30 5-hydroxytryptamine receptor 1A Homo sapiens 101-107 2317317-1 1990 Hypothermic responses to 5-HT1A receptor activation by the selective ligand ipsapirone (IPS) were attenuated in depressed patients as compared to controls. ipsapirone 76-86 5-hydroxytryptamine receptor 1A Homo sapiens 25-40 1971701-1 1990 The selective 5-HT1A receptor ligand ipsapirone (IPS) induces hypothermia in humans. ipsapirone 37-47 5-hydroxytryptamine receptor 1A Homo sapiens 14-29 1981092-2 1990 Ipsapirone, a 5-HT1A autoreceptor agonist is a representative of novel anxiolytics without the disadvantages of benzodiazepam-like drugs. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Rattus norvegicus 14-20 2141111-5 1990 Accordingly, the selective 5-HT1A agonists 8-hydroxy-2-(n-dipropylamino)tetralin and ipsapirone directly hyperpolarized motoneurons. ipsapirone 85-95 5-hydroxytryptamine receptor 1A Homo sapiens 27-33 1981264-0 1990 Ipsapirone: a novel anxiolytic and selective 5-HT1A receptor ligand. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Homo sapiens 45-60 1972996-0 1990 Evidence for the involvement of the 5-HT1A receptor in the anxiolytic action of indorenate and ipsapirone. ipsapirone 95-105 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus 36-51 1978371-1 1990 Ipsapirone is an azopirone derivative that selectively interacts with serotonin-1A (5-HT1A) receptors and fails to affect other neurotransmitter receptors. ipsapirone 0-10 5-hydroxytryptamine receptor 1A Homo sapiens 84-90 1971701-0 1990 Subsensitivity of the 5-hydroxytryptamine1A (5-HT1A) receptor-mediated hypothermic response to ipsapirone in unipolar depression. ipsapirone 95-105 5-hydroxytryptamine receptor 1A Homo sapiens 22-43 1971701-0 1990 Subsensitivity of the 5-hydroxytryptamine1A (5-HT1A) receptor-mediated hypothermic response to ipsapirone in unipolar depression. ipsapirone 95-105 5-hydroxytryptamine receptor 1A Homo sapiens 45-61 1969119-3 1990 RSA was also inhibited by 5-HT1A related anxiolytics such as buspirone, gepirone, and ipsapirone. ipsapirone 86-96 5-hydroxytryptamine receptor 1A Oryctolagus cuniculus 26-32 2287488-4 1990 Ritanserin itself and the 5-HT-1A receptor ligand ipsapirone caused either little or no effect. ipsapirone 50-60 5-hydroxytryptamine receptor 1A Homo sapiens 26-42