PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30386303-8	2018	We also previously reported that MS417, a bromodomain inhibitor that disrupts the interaction between the acetyl-residues of NF-kappaB and bromodomain-containing protein 4 (BRD4) also attenuates DKD.	MS417	33-38	bromodomain containing 4	Mus musculus	139-171
34094834-4	2021	BRD4 silencing or BET inhibitors JQ1 and MS417 prevented cardiac hypertrophic responses induced by isoproterenol (ISO), whereas overexpression of BRD4 promoted cardiac hypertrophy, confirming the critical role of BRD4 in pathological cardiac hypertrophy.	MS417	41-46	delta/notch like EGF repeat containing	Homo sapiens	18-21
30386303-8	2018	We also previously reported that MS417, a bromodomain inhibitor that disrupts the interaction between the acetyl-residues of NF-kappaB and bromodomain-containing protein 4 (BRD4) also attenuates DKD.	MS417	33-38	bromodomain containing 4	Mus musculus	173-177
23255218-2	2013	We find that BET inhibitor compounds (JQ1, I-Bet, I-Bet151 and MS417) reactivate HIV from latency.	MS417	63-68	delta/notch like EGF repeat containing	Homo sapiens	13-16
24608443-8	2014	Treatment of db/db mice with a bromodomain and extraterminal (BET)-specific bromodomain inhibitor (MS417) which blocks acetylation-mediated association of p65 and STAT3 with BET proteins, attenuated proteinuria, and kidney injury.	MS417	99-104	delta/notch-like EGF repeat containing	Mus musculus	62-65
24608443-8	2014	Treatment of db/db mice with a bromodomain and extraterminal (BET)-specific bromodomain inhibitor (MS417) which blocks acetylation-mediated association of p65 and STAT3 with BET proteins, attenuated proteinuria, and kidney injury.	MS417	99-104	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	155-158
24608443-8	2014	Treatment of db/db mice with a bromodomain and extraterminal (BET)-specific bromodomain inhibitor (MS417) which blocks acetylation-mediated association of p65 and STAT3 with BET proteins, attenuated proteinuria, and kidney injury.	MS417	99-104	signal transducer and activator of transcription 3	Mus musculus	163-168
24608443-8	2014	Treatment of db/db mice with a bromodomain and extraterminal (BET)-specific bromodomain inhibitor (MS417) which blocks acetylation-mediated association of p65 and STAT3 with BET proteins, attenuated proteinuria, and kidney injury.	MS417	99-104	delta/notch-like EGF repeat containing	Mus musculus	174-177
22645123-4	2012	We showed that our BET (Bromodomain and Extra-Terminal domain)-specific bromodomain inhibitor MS417, designed to block BRD4 binding to the acetylated NF-kappaB, effectively attenuates NF-kappaB transcriptional activation of proinflammatory genes in kidney cells treated with TNFalpha or infected by HIV.	MS417	94-99	bromodomain containing 4	Homo sapiens	119-123
22645123-4	2012	We showed that our BET (Bromodomain and Extra-Terminal domain)-specific bromodomain inhibitor MS417, designed to block BRD4 binding to the acetylated NF-kappaB, effectively attenuates NF-kappaB transcriptional activation of proinflammatory genes in kidney cells treated with TNFalpha or infected by HIV.	MS417	94-99	nuclear factor kappa B subunit 1	Homo sapiens	150-159
22645123-4	2012	We showed that our BET (Bromodomain and Extra-Terminal domain)-specific bromodomain inhibitor MS417, designed to block BRD4 binding to the acetylated NF-kappaB, effectively attenuates NF-kappaB transcriptional activation of proinflammatory genes in kidney cells treated with TNFalpha or infected by HIV.	MS417	94-99	nuclear factor kappa B subunit 1	Homo sapiens	184-193
22645123-4	2012	We showed that our BET (Bromodomain and Extra-Terminal domain)-specific bromodomain inhibitor MS417, designed to block BRD4 binding to the acetylated NF-kappaB, effectively attenuates NF-kappaB transcriptional activation of proinflammatory genes in kidney cells treated with TNFalpha or infected by HIV.	MS417	94-99	tumor necrosis factor	Homo sapiens	275-283