PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11576623-5	2001	The introduction of a 16-methyl substituent into 5alpha-androstane molecules substantially decreases the binding affinity to the androgen receptor and 16alpha-methyl derivatives were always bound more weakly than the 16beta-methyl isomers.	androstane	49-66	androgen receptor	Homo sapiens	129-146
611635-4	1977	From adrenal microsomes incubated with 1 M NaCl, up to 80% (105.7 millimicron/mg microsomes) of the total androstane-3beta-HSD activity was recovered in the supernatant following centrifugation at 130,000 x g for 1 h. The maximum amount of androstane-3beta-HSD solubilized from interstitial cell microsomes was 56% (29.5 millimicron/mg microsomes) at 2 M NaCl.	androstane	106-116	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	117-126
11118046-4	2000	L-35 and L-37 are delta5-3beta-ol-androstane derivatives, and L-36 and L-39 are delta4-3-one-androstane-derived compounds.	androstane	93-103	ribosomal protein L36	Homo sapiens	62-66
11118046-4	2000	L-35 and L-37 are delta5-3beta-ol-androstane derivatives, and L-36 and L-39 are delta4-3-one-androstane-derived compounds.	androstane	93-103	ribosomal protein L39	Homo sapiens	71-75
8818396-3	1996	The activities of 5 alpha-reductase (the enzyme that converts testosterone into dihydrotestosterone; DHT) and of 3 alpha-hydroxy steroid dehydrogenase (the enzyme that converts DHT into 5 alpha-androstane-3 alpha, 17 beta-diol; 3 alpha-diol) were first evaluated in primary cultures of neurons, oligodendrocytes, and type-1 and type-2 astrocytes, obtained from the fetal or neonatal rat brain.	androstane	194-204	aldo-keto reductase family 1, member C14	Rattus norvegicus	113-150
6894653-8	1981	The latter modifications are likely to increase the specificity of androstane derivatives for receptors other than androgen binding proteins, such as the progesterone receptor.	androstane	67-77	progesterone receptor	Rattus norvegicus	154-175
11118046-4	2000	L-35 and L-37 are delta5-3beta-ol-androstane derivatives, and L-36 and L-39 are delta4-3-one-androstane-derived compounds.	androstane	34-44	ribosomal protein L35	Homo sapiens	0-4
11118046-4	2000	L-35 and L-37 are delta5-3beta-ol-androstane derivatives, and L-36 and L-39 are delta4-3-one-androstane-derived compounds.	androstane	34-44	ribosomal protein L37	Homo sapiens	9-13
10354410-2	1999	The relative binding affinity to the androgen receptor determined in competition assays showed that in the androstane series the fluoro steroids have the highest affinity and that F-17alpha-CH3-DHT (4) has a higher affinity than 5alpha-DHT.	androstane	107-117	androgen receptor	Rattus norvegicus	37-54
9783588-0	1998	Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta.	androstane	0-10	syntaxin 8	Homo sapiens	67-75
2325413-1	1990	The relationships between structure and inhibitory potency toward microsomal cytochrome P-450 (P-450)-mediated androst-4-ene-3,17-dione hydroxylase activities were investigated in rat liver with a series of 5 alpha- and 5 beta-androstane derivatives.	androstane	227-237	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	77-93
611635-4	1977	From adrenal microsomes incubated with 1 M NaCl, up to 80% (105.7 millimicron/mg microsomes) of the total androstane-3beta-HSD activity was recovered in the supernatant following centrifugation at 130,000 x g for 1 h. The maximum amount of androstane-3beta-HSD solubilized from interstitial cell microsomes was 56% (29.5 millimicron/mg microsomes) at 2 M NaCl.	androstane	240-250	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	117-126
881104-0	1977	Relative binding affinity of androstane and C-19-nor-androstane-steroids for the estradiol-receptor in human myometrial and mammary cancer tissue.	androstane	29-39	estrogen receptor 1	Homo sapiens	81-99
5140009-2	1971	Studies on some potentially antitumor active androstane compounds containing C-17 nitrogen mustard functions.	androstane	45-55	cytokine like 1	Homo sapiens	77-81
819263-12	1976	It is suggested that one form of cytochrome P-450 catalyzes the hydroxylation of 5alpha-androstane-3alpha,17beta-diol in the 2beta- and 18-positions, another form the 12beta-, 15alpha- and 16alpha-hydroxylations of the same substrate and a third form the 15beta-hydroxylation of 5alpha-androstane-3alpha,17beta-diol3,17-disulphate.	androstane	81-98	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	33-49
819263-12	1976	It is suggested that one form of cytochrome P-450 catalyzes the hydroxylation of 5alpha-androstane-3alpha,17beta-diol in the 2beta- and 18-positions, another form the 12beta-, 15alpha- and 16alpha-hydroxylations of the same substrate and a third form the 15beta-hydroxylation of 5alpha-androstane-3alpha,17beta-diol3,17-disulphate.	androstane	81-98	cytochrome P450, family 2, subfamily c, polypeptide 12	Rattus norvegicus	255-261
819263-12	1976	It is suggested that one form of cytochrome P-450 catalyzes the hydroxylation of 5alpha-androstane-3alpha,17beta-diol in the 2beta- and 18-positions, another form the 12beta-, 15alpha- and 16alpha-hydroxylations of the same substrate and a third form the 15beta-hydroxylation of 5alpha-androstane-3alpha,17beta-diol3,17-disulphate.	androstane	279-296	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	33-49
164944-8	1975	In lecithin liposomes maximal quenching of perylene fluorescence at 25 degrees C is effected by cholestane spin label (80%) followed by androstane spin label (70%), 5-nitroxide stearate (60%) and 16-nitroxide stearate (50%).	androstane	136-146	spindlin 1	Homo sapiens	147-151
164944-17	1975	Cholestane spin label and androstane spin label at concentrations of greater than 20 mol % themselves suppress the quenching discontinuity at Tt, indicating a cholesterol-like structural effect.	androstane	26-36	spindlin 1	Homo sapiens	37-41
1213671-14	1975	Action of prolactin on the metabolism of testosterone in hypophysectomized animals: Prolactin (125 mug twice daily from the 70th to the 79th day of life) causes a significant acceleration of the delta4-5alpha-hydrogenation, which is recognized as a significant increase in the concentrations of 5alpha-androstane metabolites; the 3beta-hydroxy compounds in both sexes reach the normal level of male control animals.	androstane	295-312	prolactin	Rattus norvegicus	84-93
33157220-3	2021	The results of screening of bile acids and androstane derivatives toward human recombinant steroid 17alpha-hydroxylase/17,20-lyase (CYP17A1) are presented in this paper.	androstane	43-53	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	91-130
33157220-3	2021	The results of screening of bile acids and androstane derivatives toward human recombinant steroid 17alpha-hydroxylase/17,20-lyase (CYP17A1) are presented in this paper.	androstane	43-53	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	132-139
31902468-7	2020	In this review, we present important, recent developments in the computational prediction of the inhibition of four clinically crucial CYP isoforms (CYP1A2, 2C9, 2D6, and 3A4) and three nuclear receptors (aryl hydrocarbon receptor, constitutive androstane receptor, and pregnane X receptor) involved in the induction of CYP1A2, 2B6, and 3A4, respectively.	androstane	245-255	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	135-138
31926269-9	2020	2) Val200 is a critical determinant for exhibiting the strict 17beta-HSD activity of the enzyme, because the Val200Leu mutation resulted in both significant impairment of the 17beta-HSD activity and emergence of 3beta-HSD activity towards 5alpha-androstanes including 11KDHT.	androstane	239-257	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	62-72
31926269-9	2020	2) Val200 is a critical determinant for exhibiting the strict 17beta-HSD activity of the enzyme, because the Val200Leu mutation resulted in both significant impairment of the 17beta-HSD activity and emergence of 3beta-HSD activity towards 5alpha-androstanes including 11KDHT.	androstane	239-257	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	175-185
32551008-4	2020	Recently, steroids of the androstane group have been described as highly potent but nonselective inhibitors of parasitic glucose-6-phosphate dehydrogenase (G6PDH).	androstane	26-36	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	156-161
31982513-0	2020	Molecular docking, anti-proliferative activity and induction of apoptosis in human liver cancer cells treated with androstane derivatives: Implication of PI3K/AKT/mTOR pathway.	androstane	115-125	AKT serine/threonine kinase 1	Homo sapiens	159-162
31982513-0	2020	Molecular docking, anti-proliferative activity and induction of apoptosis in human liver cancer cells treated with androstane derivatives: Implication of PI3K/AKT/mTOR pathway.	androstane	115-125	mechanistic target of rapamycin kinase	Homo sapiens	163-167
31902468-7	2020	In this review, we present important, recent developments in the computational prediction of the inhibition of four clinically crucial CYP isoforms (CYP1A2, 2C9, 2D6, and 3A4) and three nuclear receptors (aryl hydrocarbon receptor, constitutive androstane receptor, and pregnane X receptor) involved in the induction of CYP1A2, 2B6, and 3A4, respectively.	androstane	245-255	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	149-155
31902468-7	2020	In this review, we present important, recent developments in the computational prediction of the inhibition of four clinically crucial CYP isoforms (CYP1A2, 2C9, 2D6, and 3A4) and three nuclear receptors (aryl hydrocarbon receptor, constitutive androstane receptor, and pregnane X receptor) involved in the induction of CYP1A2, 2B6, and 3A4, respectively.	androstane	245-255	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	320-326
30848264-2	2019	But whether hepatic drug-metabolizing enzymes and their regulatory nuclear receptors including pregnane PXR and constitutive androstane CAR binding with retinoid receptor RXR as a heterodimer are involved in the DBDCT-mediated regulation of CYP3A remains unclear.	androstane	125-135	CXADR pseudogene 1	Homo sapiens	136-139
31753699-4	2020	We measured the inhibitory potency of 5alpha-androstane derivatives against the formation of 5alpha-DHT, and inhibition curves were obtained for the most potent compounds (IC50 = 1.2-14.1 muM).	androstane	38-55	latexin	Homo sapiens	188-191
31753699-5	2020	The most potent inhibitor 25 (IC50 = 1.2 muM) possesses a 4-(4-CF3-3-CH3O-benzyl)piperazinyl methyl side chain at C3beta and 17beta-OH/17alpha-CCH functionalities at C17 of a 5alpha-androstane core.	androstane	175-192	latexin	Homo sapiens	41-44
31753699-5	2020	The most potent inhibitor 25 (IC50 = 1.2 muM) possesses a 4-(4-CF3-3-CH3O-benzyl)piperazinyl methyl side chain at C3beta and 17beta-OH/17alpha-CCH functionalities at C17 of a 5alpha-androstane core.	androstane	175-192	endogenous retrovirus group K member 3	Homo sapiens	114-120
31575620-5	2019	Reporter gene and chromatin immunoprecipitation assays indicated that the loss of ALDH1A7 inducibility in the rr strain is profoundly linked with a 16-base pair deletion in the proximal promoter and inability of the upstream DNA sequences to recruit constitutive androstane receptor-retinoid X receptor heterodimers.	androstane	263-273	aldehyde dehydrogenase family 1, subfamily A7	Rattus norvegicus	82-89
30848264-2	2019	But whether hepatic drug-metabolizing enzymes and their regulatory nuclear receptors including pregnane PXR and constitutive androstane CAR binding with retinoid receptor RXR as a heterodimer are involved in the DBDCT-mediated regulation of CYP3A remains unclear.	androstane	125-135	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	241-246
29752109-1	2018	An androstane (17beta-hydroxy-17alpha-picolyl-androst-5-en-3beta-yl-acetate (derivative A)) cancer inhibitor was successfully captured in a carrier made of nano-sized hydroxyapatite (HAp) coated with chitosan-PLGA polymer blends (Ch-PLGA).	androstane	3-13	reticulon 3	Homo sapiens	183-186
27694053-2	2016	In this study we utilize an emulsification process and freeze drying to load the composite HAp/Ch-PLGA particles with 17beta-hydroxy-17alpha-picolyl-androst-5-en-3beta-yl-acetate (A), a chemotherapeutic derivative of androstane and a novel compound with a selective anticancer activity against lung cancer cells.	androstane	217-227	reticulon 3	Homo sapiens	91-94
28971759-8	2018	As relevant examples, pregnenolone 20-oximes showed high activity as 17alpha-hydroxylase-17,20-lyase and 5alpha-reductase inhibitors and the introduction of an oxime group at C-6 in androstane series also led to relevant results as aromatase inhibitors.	androstane	182-192	complement C6	Homo sapiens	175-178
26780831-1	2016	In the present study, a series of steroidal tetrazole derivatives of androstane and pregnane have been prepared in which the tetrazole moiety was appended at C-3 and 17a-aza locations.	androstane	69-79	complement C3	Homo sapiens	158-161
27240521-2	2016	Clinically, an association between the constitutive androstane NR (CAR) and cognitive impairment was proposed, however never experimentally investigated.	androstane	52-62	nuclear receptor subfamily 1, group I, member 3	Mus musculus	67-70
26920053-2	2016	The recombinant protein (DHRS11) efficiently catalyzed the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5alpha-androstanes into their 17beta-hydroxyl metabolites with NADPH as a coenzyme.	androstane	128-146	dehydrogenase/reductase 11	Homo sapiens	25-31
26680489-3	2015	In the present study we evaluate the role of steroid sulfotransferase SULT2A1 in the pathophysiology of AD on the basis of circulating steroids (measured by GC-MS), in which the sulfation catalyzed by SULT2A1 dominates over glucuronidation (pregnenolone/sulfate, DHEA/sulfate, androstenediol/sulfate and 5alpha-reduced pregnane and androstane catabolites).	androstane	332-342	sulfotransferase family 2A member 1	Homo sapiens	70-77
26281846-7	2015	Basal expression was detectable in the brain, and treatment with activators of the constitutive androstane, pregnane X, and glucocorticoid receptors induced brain and spinal MDR1-luc transcription.	androstane	96-106	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	174-178
26111722-9	2015	The induction of metabolic enzymes such as CYPs and UGTs, and transporters such as P-gp, implies that the amount of these proteins increases when they are induced; this is almost always explained by increasing synthesis mediated by the so-called nuclear receptors (constitutive androstane, estrogen, glucocorticoid receptors and pregnaneX receptors).	androstane	278-288	ATP binding cassette subfamily B member 1	Homo sapiens	83-87
25455223-3	2014	The proposed MOA consists of an initial effect on the liver by activating the constitutive androstane (Car) and pregnane X (Pxr) nuclear receptors causing increased elimination of thyroid hormones followed by an increased secretion of thyroid stimulating hormone (TSH).	androstane	91-101	nuclear receptor subfamily 1, group I, member 3	Mus musculus	103-106
24277450-6	2014	Indeed, the rs12470143 SRD5A2 protective allele was associated with high circulating androstane-3alpha, 17beta-diol-17-glucuronide (3alpha-diol-17G) levels as opposed to lower levels of both 3alpha-diol-17G and androsterone-glucuronide observed with the rs2208532 SRD5A2 risk allele.	androstane	85-95	steroid 5 alpha-reductase 2	Homo sapiens	23-29
24277450-6	2014	Indeed, the rs12470143 SRD5A2 protective allele was associated with high circulating androstane-3alpha, 17beta-diol-17-glucuronide (3alpha-diol-17G) levels as opposed to lower levels of both 3alpha-diol-17G and androsterone-glucuronide observed with the rs2208532 SRD5A2 risk allele.	androstane	85-95	steroid 5 alpha-reductase 2	Homo sapiens	264-270
22434086-0	2012	The ERbeta ligand 5alpha-androstane, 3beta,17beta-diol (3beta-diol) regulates hypothalamic oxytocin (Oxt) gene expression.	androstane	18-35	estrogen receptor 2 (beta)	Mus musculus	4-10
23994323-1	2013	The aim of this study was to determine the cytotoxic effect of human cancer cells on three series of novel dehydroepiandrosterone derivatives containing triazole or pyrazole rings at C-17 and an ester moiety at C-3 of the androstane skeleton.	androstane	222-232	complement C3	Homo sapiens	211-214
23899473-2	2013	However, due to the evolutionary divergence of the constitutive androstane and pregnane-X receptors (CAR, PXR), TCS-mediated downstream effects may be species-dependent.	androstane	64-74	treacle ribosome biogenesis factor 1	Homo sapiens	112-115
22659317-10	2012	Minor up-regulation of Cyp2b and Cyp3a expression in dams was consistent with hypothesized activation of the constitutive androstane and/or pregnane X receptor.	androstane	122-132	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	33-38
22434086-0	2012	The ERbeta ligand 5alpha-androstane, 3beta,17beta-diol (3beta-diol) regulates hypothalamic oxytocin (Oxt) gene expression.	androstane	18-35	oxytocin	Mus musculus	91-99
22434086-0	2012	The ERbeta ligand 5alpha-androstane, 3beta,17beta-diol (3beta-diol) regulates hypothalamic oxytocin (Oxt) gene expression.	androstane	18-35	oxytocin	Mus musculus	101-104
22434086-5	2012	Testosterone regulation of the HPA axis thus appears to involve the conversion to the ERbeta-selective ligand 5alpha-androstane, 3beta-diol.	androstane	110-127	estrogen receptor 2 (beta)	Mus musculus	86-92
20005886-7	2010	Furthermore, constitutive androstane and pregnane X receptor (CAR/PXR) regulated genes including Cyp2b10, Cyp3a11, Ces2, Insig2 and Abcc3 were dose-dependently induced by PCB153.	androstane	26-36	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	97-104
20524938-5	2010	Interactions between matrine or oxymatrine and human constitutive androstane (CAR), pregnane X receptor were evaluated by means of the reporter gene assay in CV-1 cells.	androstane	66-76	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	78-81
20855474-0	2010	Association of SRD5A2 variants and serum androstane-3alpha,17beta-diol glucuronide concentration in Chinese elderly men.	androstane	41-51	steroid 5 alpha-reductase 2	Homo sapiens	15-21
20005886-7	2010	Furthermore, constitutive androstane and pregnane X receptor (CAR/PXR) regulated genes including Cyp2b10, Cyp3a11, Ces2, Insig2 and Abcc3 were dose-dependently induced by PCB153.	androstane	26-36	carboxylesterase 2C	Mus musculus	115-119
20005886-7	2010	Furthermore, constitutive androstane and pregnane X receptor (CAR/PXR) regulated genes including Cyp2b10, Cyp3a11, Ces2, Insig2 and Abcc3 were dose-dependently induced by PCB153.	androstane	26-36	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	106-113
20005886-7	2010	Furthermore, constitutive androstane and pregnane X receptor (CAR/PXR) regulated genes including Cyp2b10, Cyp3a11, Ces2, Insig2 and Abcc3 were dose-dependently induced by PCB153.	androstane	26-36	insulin induced gene 2	Mus musculus	121-127
19423681-7	2009	These differentially expressed genes form part of a network involving lipid, sterol, and steroid homeostatic pathways regulated by the constitutive androstane (CAR), pregnane X (PXR), peroxisome proliferator-activated alpha, and other nuclear receptors in liver.	androstane	148-158	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	160-163
20005886-7	2010	Furthermore, constitutive androstane and pregnane X receptor (CAR/PXR) regulated genes including Cyp2b10, Cyp3a11, Ces2, Insig2 and Abcc3 were dose-dependently induced by PCB153.	androstane	26-36	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	Mus musculus	132-137
18395439-7	2008	In contrast, Ciona LXR was not activated by T-0901317 or GW3965 but was activated by a limited number of oxysterols, as well as some androstane and pregnane steroids.	androstane	133-143	ecdysone receptor	Ciona intestinalis	19-22
19270015-3	2009	Putative constitutive active/androstane (CAR) response elements (CAREs), a subset of PB response elements, were present within multiple genes whose expression was uniquely altered in the B6C3F1 mice, suggesting a role for CAR in their regulation.	androstane	29-39	nuclear receptor subfamily 1, group I, member 3	Mus musculus	41-44
19270015-3	2009	Putative constitutive active/androstane (CAR) response elements (CAREs), a subset of PB response elements, were present within multiple genes whose expression was uniquely altered in the B6C3F1 mice, suggesting a role for CAR in their regulation.	androstane	29-39	nuclear receptor subfamily 1, group I, member 3	Mus musculus	65-68
18252781-1	2008	CONTEXT: Dihydrotestosterone (DHT), the primary active androgen in peripheral target tissues, is metabolized by 3alpha-hydroxysteroid dehydrogenase type III (3alpha-HSD), encoded by the AKR1C2 gene, forming 5alpha-androstane-3alpha,17beta-diol (3alpha-diol).	androstane	207-224	aldo-keto reductase family 1 member C4	Homo sapiens	158-168
18471780-2	2008	It is generally thought that DHT is produced from the 5alpha-reduction of circulating T before being inactivated by 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) that converts DHT into 5alpha-androstane-3alpha,17beta-diol (3alpha-diol).	androstane	188-205	aldo-keto reductase family 1 member C3	Homo sapiens	116-151
18471780-2	2008	It is generally thought that DHT is produced from the 5alpha-reduction of circulating T before being inactivated by 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD) that converts DHT into 5alpha-androstane-3alpha,17beta-diol (3alpha-diol).	androstane	188-205	aldo-keto reductase family 1 member C3	Homo sapiens	153-163
18252781-1	2008	CONTEXT: Dihydrotestosterone (DHT), the primary active androgen in peripheral target tissues, is metabolized by 3alpha-hydroxysteroid dehydrogenase type III (3alpha-HSD), encoded by the AKR1C2 gene, forming 5alpha-androstane-3alpha,17beta-diol (3alpha-diol).	androstane	207-224	aldo-keto reductase family 1 member C2	Homo sapiens	186-192
14978227-1	2004	Human constitutive androstane (or active) receptor (hCAR), a member of the nuclear receptor superfamily NR1I3, regulates the expression of several genes that are mainly involved in the metabolism of endogenous and xenobiotic compounds (e.g., CYP2B6, CYP3A4, and UGT1A1).	androstane	19-29	CXADR Ig-like cell adhesion molecule	Homo sapiens	52-56
14978227-1	2004	Human constitutive androstane (or active) receptor (hCAR), a member of the nuclear receptor superfamily NR1I3, regulates the expression of several genes that are mainly involved in the metabolism of endogenous and xenobiotic compounds (e.g., CYP2B6, CYP3A4, and UGT1A1).	androstane	19-29	nuclear receptor subfamily 1 group I member 3	Homo sapiens	104-109
14978227-1	2004	Human constitutive androstane (or active) receptor (hCAR), a member of the nuclear receptor superfamily NR1I3, regulates the expression of several genes that are mainly involved in the metabolism of endogenous and xenobiotic compounds (e.g., CYP2B6, CYP3A4, and UGT1A1).	androstane	19-29	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	242-248
14978227-1	2004	Human constitutive androstane (or active) receptor (hCAR), a member of the nuclear receptor superfamily NR1I3, regulates the expression of several genes that are mainly involved in the metabolism of endogenous and xenobiotic compounds (e.g., CYP2B6, CYP3A4, and UGT1A1).	androstane	19-29	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	250-256
14978227-1	2004	Human constitutive androstane (or active) receptor (hCAR), a member of the nuclear receptor superfamily NR1I3, regulates the expression of several genes that are mainly involved in the metabolism of endogenous and xenobiotic compounds (e.g., CYP2B6, CYP3A4, and UGT1A1).	androstane	19-29	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	262-268
12957672-3	2003	Preliminary assessment of inhibitory effects of D-homo derivatives from androstane series towards aromatase, 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD), 17 alpha-hydroxylase/C17-20 lyase (P450c17) and 17 beta-HSD indicated much lower inhibitory potential compared to previously tested activity of another type of D-modified steroids, namely D-seco derivatives.	androstane	72-82	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	146-156
15937975-1	2005	(1)H and (13)C NMR spectroscopic data for 5alpha-androstanes and halo-5alpha-androstanes with different substituents at positions C-3, C-9, C-11 and C-17 were examined and assigned by a combination of 1D and 2D NMR experiments.	androstane	42-60	cytokine like 1	Homo sapiens	149-153