PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 35112407-3 2022 Here we present the one-pot chemical synthesis of the thioredoxin-like domain of SELENOF, highlighted by the use of Fmoc-protected selenazolidine, native chemical ligations and deselenization reactions. Selenazolidine 131-145 selenoprotein F Homo sapiens 81-88 31408267-3 2019 WT-TSTD1 was synthesized in a C-to-N synthetic approach involving multiple NCL reactions, CuII -mediated deprotection of selenazolidine (Sez), and chemoselective deselenization. Selenazolidine 121-135 thiosulfate sulfurtransferase like domain containing 1 Homo sapiens 3-8 20920480-0 2011 Thioredoxin reductase 1 knockdown enhances selenazolidine cytotoxicity in human lung cancer cells via mitochondrial dysfunction. Selenazolidine 43-57 thioredoxin reductase 1 Homo sapiens 0-23 20920480-11 2011 TR1 knockdown increased selenazolidine and SECY-induced mitochondrial membrane depolarization, as well as DNA strand breaks and AIF translocation from the mitochondria. Selenazolidine 24-38 thioredoxin reductase 1 Homo sapiens 0-3