PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22963837-8	2012	In addition, CHO (25 mug/muL) inhibited not only the SA-induced cell apoptosis by up-regulating Bcl-2 level, but also the global DNA methylation by increasing the expressions of DNMT1 and DNMT3a.	sodium arsenite	53-55	BCL2, apoptosis regulator	Gallus gallus	96-101
22683347-5	2012	We demonstrate that non cytotoxic concentrations of sodium arsenite (As(III), 0.25-2muM) significantly reduce T cell proliferation by increasing the percentage of non dividing cells blocked in G1 phase and by preventing cyclin D3 and CDC25A expression.	sodium arsenite	52-67	latexin	Homo sapiens	84-87
22959463-6	2012	LCL exposed to sodium arsenite for 8-days induced expression of UPR-activated genes, including CHOP and GRP78, at the RNA and the protein level.	sodium arsenite	15-30	DNA damage inducible transcript 3	Homo sapiens	95-99
22959463-6	2012	LCL exposed to sodium arsenite for 8-days induced expression of UPR-activated genes, including CHOP and GRP78, at the RNA and the protein level.	sodium arsenite	15-30	heat shock protein family A (Hsp70) member 5	Homo sapiens	104-109
22683347-5	2012	We demonstrate that non cytotoxic concentrations of sodium arsenite (As(III), 0.25-2muM) significantly reduce T cell proliferation by increasing the percentage of non dividing cells blocked in G1 phase and by preventing cyclin D3 and CDC25A expression.	sodium arsenite	52-67	cyclin D3	Homo sapiens	220-229
22683347-5	2012	We demonstrate that non cytotoxic concentrations of sodium arsenite (As(III), 0.25-2muM) significantly reduce T cell proliferation by increasing the percentage of non dividing cells blocked in G1 phase and by preventing cyclin D3 and CDC25A expression.	sodium arsenite	52-67	cell division cycle 25A	Homo sapiens	234-240
22824620-0	2012	Sodium arsenite-induced abnormalities in expressions of Caveolin-1, eNOS, IKKbeta, and COX-2 in SV-40 immortalized human uroepithelial cells and in urothelial carcinomas.	sodium arsenite	0-15	caveolin 1	Homo sapiens	56-66
22824620-0	2012	Sodium arsenite-induced abnormalities in expressions of Caveolin-1, eNOS, IKKbeta, and COX-2 in SV-40 immortalized human uroepithelial cells and in urothelial carcinomas.	sodium arsenite	0-15	nitric oxide synthase 3	Homo sapiens	68-72
22824620-0	2012	Sodium arsenite-induced abnormalities in expressions of Caveolin-1, eNOS, IKKbeta, and COX-2 in SV-40 immortalized human uroepithelial cells and in urothelial carcinomas.	sodium arsenite	0-15	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	74-81
22824620-0	2012	Sodium arsenite-induced abnormalities in expressions of Caveolin-1, eNOS, IKKbeta, and COX-2 in SV-40 immortalized human uroepithelial cells and in urothelial carcinomas.	sodium arsenite	0-15	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	87-92
22824620-3	2012	The aim of this study was to determine the effect of sodium arsenite on Caveolin-1 and downstream signaling molecules (eNOS, IKKbeta and COX-2) expression in human urothelial cells (SV-HUC-1).	sodium arsenite	53-68	caveolin 1	Homo sapiens	72-82
22824620-3	2012	The aim of this study was to determine the effect of sodium arsenite on Caveolin-1 and downstream signaling molecules (eNOS, IKKbeta and COX-2) expression in human urothelial cells (SV-HUC-1).	sodium arsenite	53-68	nitric oxide synthase 3	Homo sapiens	119-123
22580386-4	2012	Moreover, induction of HO-1 with sodium arsenite led to 2.4-fold (p = 0.01) accumulation of intracellular UCB over basal level while sodium azide-derived oxidative stress resulted in a 60% drop (p < 0.001).	sodium arsenite	33-48	heme oxygenase 1	Homo sapiens	23-27
22829599-4	2012	Similarly treatment of cells with puromycin or sodium arsenite, reagents that arrest translation, also resulted in the accumulation of DEF6 in cytoplasmic granules.	sodium arsenite	47-62	DEF6 guanine nucleotide exchange factor	Homo sapiens	135-139
22331493-0	2012	Sodium arsenite +- hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses.	sodium arsenite	0-15	tumor protein p53	Homo sapiens	43-46
22931810-0	2012	[Mechanism of the apoptosis of rat pancreas islet beta cell strain (INS-1 cells) induced by sodium arsenite].	sodium arsenite	92-107	insulin 1	Rattus norvegicus	68-73
22931810-1	2012	OBJECTIVE: To study mechanism of the apoptosis of rat pancreas islet beta cell strain (INS-1 cells) induced by sodium arsenite.	sodium arsenite	111-126	insulin 1	Rattus norvegicus	87-92
22931810-2	2012	METHODS: INS-1 cells were exposed to sodium arsenite at the different concentrations.	sodium arsenite	37-52	insulin 1	Rattus norvegicus	9-14
22931810-5	2012	The apoptotic levels of INS-1 cells exposed to sodium arsenite were observed by a fluorescence microscope and flow cytometry.	sodium arsenite	47-62	insulin 1	Rattus norvegicus	24-29
22931810-6	2012	RESULTS: After exposure to sodium arsenite, the viability of INS-1 cells significantly decreased with the doses of sodium arsenite.	sodium arsenite	27-42	insulin 1	Rattus norvegicus	61-66
22931810-6	2012	RESULTS: After exposure to sodium arsenite, the viability of INS-1 cells significantly decreased with the doses of sodium arsenite.	sodium arsenite	115-130	insulin 1	Rattus norvegicus	61-66
22931810-11	2012	The results detected with flow cytometry indicated that after exposure, the apoptotic INS-1E cells significantly increased with the doses of sodium arsenite.	sodium arsenite	141-156	insulin 1	Rattus norvegicus	86-91
22931810-12	2012	CONCLUSIONS: The sodium arsenite can induce the apoptosis of INS-1 cells through the mitochondria-lysosome pathway.	sodium arsenite	17-32	insulin 1	Rattus norvegicus	61-66
22627131-0	2012	Sodium arsenite down-regulates the expression of X-linked inhibitor of apoptosis protein via translational and post-translational mechanisms in hepatocellular carcinoma.	sodium arsenite	0-15	X-linked inhibitor of apoptosis	Homo sapiens	49-88
22627131-5	2012	In this study, we identified XIAP as a target for sodium arsenite-induced cytotoxicity in HCC.	sodium arsenite	50-65	X-linked inhibitor of apoptosis	Homo sapiens	29-33
22627131-6	2012	The exposure of HCC cell lines to sodium arsenite resulted in inhibition of XIAP expression in both a dose- and time-dependent manner.	sodium arsenite	34-49	X-linked inhibitor of apoptosis	Homo sapiens	76-80
22627131-7	2012	Sodium arsenite blocked the de novo XIAP synthesis and the activity of its internal ribosome entry site (IRES) element.	sodium arsenite	0-15	X-linked inhibitor of apoptosis	Homo sapiens	36-40
22627131-8	2012	Moreover, treatment with sodium arsenite decreased the protein stability of XIAP and induced its ubiquitin-proteasomal degradation.	sodium arsenite	25-40	X-linked inhibitor of apoptosis	Homo sapiens	76-80
22627131-9	2012	Overexpression of XIAP attenuated the pro-apoptotic effect of sodium arsenite in HCC.	sodium arsenite	62-77	X-linked inhibitor of apoptosis	Homo sapiens	18-22
22627131-10	2012	Taken together, our data demonstrate that sodium arsenite suppresses XIAP expression via translational and post-translational mechanisms in HCC.	sodium arsenite	42-57	X-linked inhibitor of apoptosis	Homo sapiens	69-73
22331493-10	2012	XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin.	sodium arsenite	95-110	tumor protein p53	Homo sapiens	180-183
22331493-11	2012	Hyperthermia +- sodium arsenite enhanced cellular and DNA accumulation of platinum in wild-type p53-expressing cells.	sodium arsenite	16-31	tumor protein p53	Homo sapiens	96-99
22331493-13	2012	In conclusion, sodium arsenite +- hyperthermia sensitizes wild-type p53-expressing EOC cells to cisplatin by suppressing DNA repair protein XPC and increasing cellular and DNA platinum accumulation.	sodium arsenite	15-30	tumor protein p53	Homo sapiens	68-71
22521605-7	2012	In addition, treatment of FvB mice with 100 ppb sodium arsenite in the drinking water for 6 months starting at weaning age resulted in dramatically higher levels of CRP in both the liver and inner medullary region of the kidney.	sodium arsenite	48-63	C-reactive protein, pentraxin-related	Mus musculus	165-168
25243001-3	2012	OBJECTIVE: The aim of this study was to investigate the harmful effects of sodium arsenite on sperm parameters and the antioxidant effects of Vit.E on sperm anomalies in sodium arsenite treated rats.	sodium arsenite	170-185	vitrin	Rattus norvegicus	142-145
25243001-12	2012	In sodium arsenite+Vit.E group, Vit.E could significantly compensate the harmful effects of sodium arsenite on sperm number, motility, viability and morphology compared to sodium arsenite group.	sodium arsenite	3-18	vitrin	Rattus norvegicus	32-35
25243001-12	2012	In sodium arsenite+Vit.E group, Vit.E could significantly compensate the harmful effects of sodium arsenite on sperm number, motility, viability and morphology compared to sodium arsenite group.	sodium arsenite	92-107	vitrin	Rattus norvegicus	19-22
25243001-12	2012	In sodium arsenite+Vit.E group, Vit.E could significantly compensate the harmful effects of sodium arsenite on sperm number, motility, viability and morphology compared to sodium arsenite group.	sodium arsenite	92-107	vitrin	Rattus norvegicus	32-35
25243001-12	2012	In sodium arsenite+Vit.E group, Vit.E could significantly compensate the harmful effects of sodium arsenite on sperm number, motility, viability and morphology compared to sodium arsenite group.	sodium arsenite	92-107	vitrin	Rattus norvegicus	19-22
25243001-12	2012	In sodium arsenite+Vit.E group, Vit.E could significantly compensate the harmful effects of sodium arsenite on sperm number, motility, viability and morphology compared to sodium arsenite group.	sodium arsenite	92-107	vitrin	Rattus norvegicus	32-35
25243001-13	2012	In addition, sperm viability and motility was significantly increased in rats treated with Vit.E alone compared to the control and sodium arsenite+Vit.E group.	sodium arsenite	131-146	vitrin	Rattus norvegicus	91-94
22367689-2	2012	When HaCaT keratinocytes were exposed to 1-200muM sodium arsenite, we observed perinuclear localization of HDAC6 within 30 min.	sodium arsenite	50-65	histone deacetylase 6	Homo sapiens	107-112
22367689-3	2012	Although the overall level of HDAC6 protein did not change, sodium arsenite caused an increase of HDAC6 in ribosomal fractions.	sodium arsenite	60-75	histone deacetylase 6	Homo sapiens	98-103
22426358-0	2012	Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1.	sodium arsenite	0-15	myogenin	Mus musculus	44-52
22426358-0	2012	Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1.	sodium arsenite	0-15	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	139-143
22331493-13	2012	In conclusion, sodium arsenite +- hyperthermia sensitizes wild-type p53-expressing EOC cells to cisplatin by suppressing DNA repair protein XPC and increasing cellular and DNA platinum accumulation.	sodium arsenite	15-30	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	140-143
22331493-4	2012	In this study, we examined the role of p53 status in EOC response to a novel combination of cisplatin, sodium arsenite, and hyperthermia.	sodium arsenite	103-118	tumor protein p53	Homo sapiens	39-42
22331493-5	2012	Human EOC cells were treated with cisplatin +- 20muM sodium arsenite at 37 C or 39 C for 1 h. Sodium arsenite +- hyperthermia sensitized wild-type p53-expressing (A2780, A2780/CP70, OVCA 420, OVCA 429, and OVCA 433) EOC cells to cisplatin.	sodium arsenite	94-109	tumor protein p53	Homo sapiens	147-150
22331493-7	2012	P53 small interfering RNA (siRNA) transfection abrogated sodium arsenite sensitization effect.	sodium arsenite	57-72	tumor protein p53	Homo sapiens	0-3
22331493-9	2012	Cotreatment with sodium arsenite +- hyperthermia attenuated cisplatin-induced XPC in wild-type p53-expressing cells.	sodium arsenite	17-32	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	78-81
22331493-9	2012	Cotreatment with sodium arsenite +- hyperthermia attenuated cisplatin-induced XPC in wild-type p53-expressing cells.	sodium arsenite	17-32	tumor protein p53	Homo sapiens	95-98
22331493-10	2012	XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin.	sodium arsenite	95-110	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	0-3
22426358-0	2012	Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1.	sodium arsenite	0-15	euchromatic histone methyltransferase 1	Mus musculus	145-148
22331493-10	2012	XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin.	sodium arsenite	95-110	tumor protein p53	Homo sapiens	44-47
22426358-0	2012	Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1.	sodium arsenite	0-15	insulin-like growth factor 1	Mus musculus	154-159
22426358-2	2012	Previous studies indicate that 20 nM sodium arsenite exposure to C2C12 mouse myocyte cells delayed myoblast differentiation due to reduced myogenin expression, the transcription factor that differentiates myoblasts into myotubes.	sodium arsenite	37-52	myogenin	Mus musculus	139-147
22331493-10	2012	XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin.	sodium arsenite	95-110	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	142-145
22508046-2	2012	MiR-206 was characterized previously as a differentially expressed gene in sodium arsenite (SA)-induced neural tube defects (NTDs) in chick embryos via miRNA microarray analysis.	sodium arsenite	75-90	microRNA 206	Gallus gallus	0-7
22002864-3	2012	In this study, we found that inhibition of p38 MAPK with SB-203580 (SB) reduced H(2)O(2)-stimulated secretion of TNF-alpha, whereas pre-activation of p38 MAPK with sodium arsenite (SA) enhanced H(2)O(2)-stimulated secretion of TNF-alpha.	sodium arsenite	164-179	mitogen-activated protein kinase 14	Homo sapiens	43-46
22002864-3	2012	In this study, we found that inhibition of p38 MAPK with SB-203580 (SB) reduced H(2)O(2)-stimulated secretion of TNF-alpha, whereas pre-activation of p38 MAPK with sodium arsenite (SA) enhanced H(2)O(2)-stimulated secretion of TNF-alpha.	sodium arsenite	164-179	mitogen-activated protein kinase 14	Homo sapiens	150-153
22002864-3	2012	In this study, we found that inhibition of p38 MAPK with SB-203580 (SB) reduced H(2)O(2)-stimulated secretion of TNF-alpha, whereas pre-activation of p38 MAPK with sodium arsenite (SA) enhanced H(2)O(2)-stimulated secretion of TNF-alpha.	sodium arsenite	181-183	mitogen-activated protein kinase 14	Homo sapiens	43-46
22002864-3	2012	In this study, we found that inhibition of p38 MAPK with SB-203580 (SB) reduced H(2)O(2)-stimulated secretion of TNF-alpha, whereas pre-activation of p38 MAPK with sodium arsenite (SA) enhanced H(2)O(2)-stimulated secretion of TNF-alpha.	sodium arsenite	181-183	mitogen-activated protein kinase 14	Homo sapiens	150-153
22002864-5	2012	Finally, H(2)O(2)-induced apoptosis was attenuated by the inhibitors of p38 MAPK or reactive oxygen species (ROS), whereas it was enhanced by p38 MAPK agonist SA.	sodium arsenite	159-161	mitogen-activated protein kinase 14	Homo sapiens	142-145
21954225-5	2012	METHODS: As-transformed p53lowHBECs were generated by exposing p53-knockdown HBECs to sodium arsenite (2.5 muM) for 16 weeks.	sodium arsenite	86-101	tumor protein p53	Homo sapiens	24-27
22508046-2	2012	MiR-206 was characterized previously as a differentially expressed gene in sodium arsenite (SA)-induced neural tube defects (NTDs) in chick embryos via miRNA microarray analysis.	sodium arsenite	92-94	microRNA 206	Gallus gallus	0-7
22508046-4	2012	In this study we found differential expression of miR-206 in SA-treated chick embryos by Northern blot analysis.	sodium arsenite	61-63	microRNA 206	Gallus gallus	50-57
22768106-6	2012	HSF1 was phosphorylated on S326 immediately after heat shock and was triggered by other cell stressors including proteasome inhibitors and sodium arsenite.	sodium arsenite	139-154	heat shock transcription factor 1	Homo sapiens	0-4
21819629-10	2011	JNK inhibition also inhibited TDP-43 SG localization in cells acutely treated with sodium arsenite and reduced the number of aggregates per cell in cultures transfected with C-terminal TDP-43 162-414 and 219-414 constructs.	sodium arsenite	83-98	mitogen-activated protein kinase 8	Homo sapiens	0-3
21910007-1	2011	Treatment of melanoma cells by sodium arsenite or statins (simvastatin and lovastatin) dramatically modified activities of the main cell signaling pathways resulting in the induction of heme oxygenase-1 (HO-1) and in a downregulation of cyclooxygenase-2 (COX-2) protein levels.	sodium arsenite	31-46	heme oxygenase 1	Homo sapiens	186-202
21910007-1	2011	Treatment of melanoma cells by sodium arsenite or statins (simvastatin and lovastatin) dramatically modified activities of the main cell signaling pathways resulting in the induction of heme oxygenase-1 (HO-1) and in a downregulation of cyclooxygenase-2 (COX-2) protein levels.	sodium arsenite	31-46	heme oxygenase 1	Homo sapiens	204-208
21910007-1	2011	Treatment of melanoma cells by sodium arsenite or statins (simvastatin and lovastatin) dramatically modified activities of the main cell signaling pathways resulting in the induction of heme oxygenase-1 (HO-1) and in a downregulation of cyclooxygenase-2 (COX-2) protein levels.	sodium arsenite	31-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	237-253
21910007-1	2011	Treatment of melanoma cells by sodium arsenite or statins (simvastatin and lovastatin) dramatically modified activities of the main cell signaling pathways resulting in the induction of heme oxygenase-1 (HO-1) and in a downregulation of cyclooxygenase-2 (COX-2) protein levels.	sodium arsenite	31-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	255-260
21596116-3	2011	GAL1 gene knockdown significantly attenuated sodium arsenite (NaAsO(2)) and arsenic trioxide (As(2)O(3)) inhibition of cell survival.	sodium arsenite	45-60	lectin, galactose binding, soluble 1	Mus musculus	0-4
21910007-4	2011	We demonstrated in the present study that treatment by sodium arsenite or statins with an additional inhibition of HO-1 expression (or activation) caused a substantial upregulation of apoptosis in melanoma cells.	sodium arsenite	55-70	heme oxygenase 1	Homo sapiens	115-119
21819629-10	2011	JNK inhibition also inhibited TDP-43 SG localization in cells acutely treated with sodium arsenite and reduced the number of aggregates per cell in cultures transfected with C-terminal TDP-43 162-414 and 219-414 constructs.	sodium arsenite	83-98	TAR DNA binding protein	Homo sapiens	30-36
21440049-3	2011	The present study stresses the hypothesis whether sodium arsenite, and its main metabolite, dimethylarsinic acid (DMA), may affect expression and processing of the amyloid precursor protein (APP), using the cholinergic cell line SN56.B5.G4 and primary neuronal cells overexpressing the Swedish mutation of APP, as experimental approaches.	sodium arsenite	50-65	amyloid beta (A4) precursor protein	Mus musculus	164-189
21861350-3	2011	RESULTS: When exposed to 5, 10, 25 and 50 micromol/L of NaAsO2, Nrf2 mRNA were (100.74 +/- 3.70)%, (105.96 +/- 1.75)%, (101.76 +/- 1.01)% and (101.81 +/- 6.33)% of control,showing no statistic significance (P > 0.05).	sodium arsenite	56-62	NFE2 like bZIP transcription factor 2	Homo sapiens	64-68
21861350-5	2011	Moreover, HO-1 mRNA expression were also significantly induced by sodium arsenite exposure, and a definite dose-effect relationship was confirmed (P < 0.01).	sodium arsenite	66-81	heme oxygenase 1	Homo sapiens	10-14
21696631-10	2011	NaAsO2 prevented XPC induction by cisplatin; it maintained higher levels of MSH2 in tumors and enhanced initial accumulation of Pt in tumors.	sodium arsenite	0-6	xeroderma pigmentosum, complementation group C	Mus musculus	17-20
21696631-10	2011	NaAsO2 prevented XPC induction by cisplatin; it maintained higher levels of MSH2 in tumors and enhanced initial accumulation of Pt in tumors.	sodium arsenite	0-6	mutS homolog 2	Mus musculus	76-80
21696631-11	2011	Combined NaAsO2 and hyperthermia decreased cisplatin-induced XPC 24 h after perfusion, maintained higher levels of MSH2 in tumors and significantly increased initial accumulation of Pt in tumors.	sodium arsenite	9-15	xeroderma pigmentosum, complementation group C	Mus musculus	61-64
21696631-11	2011	Combined NaAsO2 and hyperthermia decreased cisplatin-induced XPC 24 h after perfusion, maintained higher levels of MSH2 in tumors and significantly increased initial accumulation of Pt in tumors.	sodium arsenite	9-15	mutS homolog 2	Mus musculus	115-119
21642427-0	2011	The ETS family transcription factor ELK-1 regulates induction of the cell cycle-regulatory gene p21(Waf1/Cip1) and the BAX gene in sodium arsenite-exposed human keratinocyte HaCaT cells.	sodium arsenite	131-146	ETS transcription factor ELK1	Homo sapiens	36-41
21642427-0	2011	The ETS family transcription factor ELK-1 regulates induction of the cell cycle-regulatory gene p21(Waf1/Cip1) and the BAX gene in sodium arsenite-exposed human keratinocyte HaCaT cells.	sodium arsenite	131-146	cyclin dependent kinase inhibitor 1A	Homo sapiens	96-110
21642427-0	2011	The ETS family transcription factor ELK-1 regulates induction of the cell cycle-regulatory gene p21(Waf1/Cip1) and the BAX gene in sodium arsenite-exposed human keratinocyte HaCaT cells.	sodium arsenite	131-146	BCL2 associated X, apoptosis regulator	Homo sapiens	119-122
21642427-3	2011	Here, we show that ELK-1 directly trans-activates the p21 gene, independently of p53 and EGR-1, in sodium arsenite (NaASO(2))-exposed HaCaT cells.	sodium arsenite	99-114	ETS transcription factor ELK1	Homo sapiens	19-24
21642427-3	2011	Here, we show that ELK-1 directly trans-activates the p21 gene, independently of p53 and EGR-1, in sodium arsenite (NaASO(2))-exposed HaCaT cells.	sodium arsenite	99-114	cyclin dependent kinase inhibitor 1A	Homo sapiens	54-57
21642427-6	2011	In addition, NaASO(2)-induced p21 promoter activity was enhanced by exogenous expression of ELK-1 and reduced by expression of siRNA targeted to ELK-1 mRNA.	sodium arsenite	13-21	cyclin dependent kinase inhibitor 1A	Homo sapiens	30-33
21642427-6	2011	In addition, NaASO(2)-induced p21 promoter activity was enhanced by exogenous expression of ELK-1 and reduced by expression of siRNA targeted to ELK-1 mRNA.	sodium arsenite	13-21	ETS transcription factor ELK1	Homo sapiens	92-97
21642427-6	2011	In addition, NaASO(2)-induced p21 promoter activity was enhanced by exogenous expression of ELK-1 and reduced by expression of siRNA targeted to ELK-1 mRNA.	sodium arsenite	13-21	ETS transcription factor ELK1	Homo sapiens	145-150
21861350-2	2011	METHODS: Chang hepatocytes were treated with 5, 10, 25 and 50 micromol/L of sodium arsenite (NaAsO2) for 6h, and RT-PCR were then performed to detect the mRNA expression of Nrf2, NQO1 and HO-1.	sodium arsenite	76-91	NFE2 like bZIP transcription factor 2	Homo sapiens	173-177
21440049-4	2011	Exposure of cholinergic SN56.B5.G4 cells with either sodium arsenite or DMA decreased cell viability in a concentration- and exposure-time dependent manner, and affected the activities of the cholinergic enzymes acetylcholinesterase and choline acetyltransferase.	sodium arsenite	53-68	choline acetyltransferase	Mus musculus	237-262
21234798-5	2011	In addition, we show that SMN deficiency sensitizes cells to sodium arsenite and H(2)O(2), two well-known stress inducers, leading to cell death at a much lower concentration of inducers in SMN knockdown cells than in control cells.	sodium arsenite	61-76	survival of motor neuron 1, telomeric	Homo sapiens	26-29
21427224-4	2011	In MC3T3-E1 cells, pretreatment with sphingosine 1-phosphate, sodium arsenite, or heat stress caused the attenuation of osteocalcin synthesis induced by BMP-4 or T3 with concurrent HSP27 induction.	sodium arsenite	62-77	bone gamma-carboxyglutamate protein 2	Mus musculus	120-131
21427224-4	2011	In MC3T3-E1 cells, pretreatment with sphingosine 1-phosphate, sodium arsenite, or heat stress caused the attenuation of osteocalcin synthesis induced by BMP-4 or T3 with concurrent HSP27 induction.	sodium arsenite	62-77	bone morphogenetic protein 4	Mus musculus	153-158
21427224-4	2011	In MC3T3-E1 cells, pretreatment with sphingosine 1-phosphate, sodium arsenite, or heat stress caused the attenuation of osteocalcin synthesis induced by BMP-4 or T3 with concurrent HSP27 induction.	sodium arsenite	62-77	heat shock protein 1	Mus musculus	181-186
21281968-4	2011	We report that in vitro pre-treatment of PBMC with sodium arsenite (NaAs) reduces IL2 secretion and T cell proliferation induced by PHA, but does not prevent expression of monocyte-derived cytokines (IL1, IL6, TNFalpha) functioning as lymphocyte-activating factors.	sodium arsenite	51-66	interleukin 2	Homo sapiens	82-85
20390378-5	2011	The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3.	sodium arsenite	4-10	tumor protein p53	Homo sapiens	54-57
20390378-5	2011	The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3.	sodium arsenite	4-10	BCL2 apoptosis regulator	Homo sapiens	89-94
20390378-5	2011	The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3.	sodium arsenite	4-10	tumor protein p53	Homo sapiens	131-134
20390378-5	2011	The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3.	sodium arsenite	188-194	tumor protein p53	Homo sapiens	54-57
20390378-5	2011	The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3.	sodium arsenite	188-194	BCL2 apoptosis regulator	Homo sapiens	89-94
20390378-5	2011	The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3.	sodium arsenite	188-194	tumor protein p53	Homo sapiens	131-134
20390378-6	2011	Thus, our results indicate upregulation of p53 and Bcl-2 play acrucial role in the NaAsO2-induced G1 arrest and apoptosis of A375 cells and that downregulation p53 appears to contribute to the inhibition by Na2SeO3 of the effects induced by NaAsO2.	sodium arsenite	83-89	tumor protein p53	Homo sapiens	43-46
20390378-6	2011	Thus, our results indicate upregulation of p53 and Bcl-2 play acrucial role in the NaAsO2-induced G1 arrest and apoptosis of A375 cells and that downregulation p53 appears to contribute to the inhibition by Na2SeO3 of the effects induced by NaAsO2.	sodium arsenite	83-89	BCL2 apoptosis regulator	Homo sapiens	51-56
20390378-6	2011	Thus, our results indicate upregulation of p53 and Bcl-2 play acrucial role in the NaAsO2-induced G1 arrest and apoptosis of A375 cells and that downregulation p53 appears to contribute to the inhibition by Na2SeO3 of the effects induced by NaAsO2.	sodium arsenite	83-89	tumor protein p53	Homo sapiens	160-163
20390378-6	2011	Thus, our results indicate upregulation of p53 and Bcl-2 play acrucial role in the NaAsO2-induced G1 arrest and apoptosis of A375 cells and that downregulation p53 appears to contribute to the inhibition by Na2SeO3 of the effects induced by NaAsO2.	sodium arsenite	241-247	tumor protein p53	Homo sapiens	43-46
21266531-6	2011	We show that sodium arsenite induces ABCB6 expression in a dose-dependent manner both in mice fed sodium arsenite in drinking water and in cells exposed to sodium arsenite in vitro.	sodium arsenite	13-28	ATP-binding cassette, sub-family B (MDR/TAP), member 6	Mus musculus	37-42
21266531-6	2011	We show that sodium arsenite induces ABCB6 expression in a dose-dependent manner both in mice fed sodium arsenite in drinking water and in cells exposed to sodium arsenite in vitro.	sodium arsenite	98-113	ATP-binding cassette, sub-family B (MDR/TAP), member 6	Mus musculus	37-42
21266531-6	2011	We show that sodium arsenite induces ABCB6 expression in a dose-dependent manner both in mice fed sodium arsenite in drinking water and in cells exposed to sodium arsenite in vitro.	sodium arsenite	98-113	ATP-binding cassette, sub-family B (MDR/TAP), member 6	Mus musculus	37-42
21266531-10	2011	Collectively, these results, obtained by both loss of function and gain of function analysis, suggest that ABCB6 expression in response to sodium arsenite might be an endogenous protective mechanism activated to protect cells against arsenite-induced oxidative stress.	sodium arsenite	139-154	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	107-112
21292642-4	2011	We found that prolonged exposure of immortalized p53-knocked down human bronchial epithelial cells (p53(low)HBECs) to low levels of arsenite (NaAsO2, 2.5 muM) caused malignant transformation that was accompanied by epithelial to mesenchymal transition (EMT) and reduction in the levels of miR-200 family members.	sodium arsenite	142-148	tumor protein p53	Homo sapiens	49-52
21281968-4	2011	We report that in vitro pre-treatment of PBMC with sodium arsenite (NaAs) reduces IL2 secretion and T cell proliferation induced by PHA, but does not prevent expression of monocyte-derived cytokines (IL1, IL6, TNFalpha) functioning as lymphocyte-activating factors.	sodium arsenite	51-66	tumor necrosis factor	Homo sapiens	210-218
22181980-0	2011	Antagonistic role of tea against sodium arsenite-induced oxidative DNA damage and inhibition of DNA repair in Swiss albino mice.	sodium arsenite	33-48	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	21-24
21643505-5	2011	While ten of the metals tested (cadmium, cobalt, copper, gold, iron, lead, mercury, silver, sodium arsenite and zinc) stimulated Nrf2-dependent transcriptional activity in at least three of the engineered cell lines, only three (cadmium, copper and sodium arsenite) were active in all five cell lines.	sodium arsenite	92-107	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
21643505-5	2011	While ten of the metals tested (cadmium, cobalt, copper, gold, iron, lead, mercury, silver, sodium arsenite and zinc) stimulated Nrf2-dependent transcriptional activity in at least three of the engineered cell lines, only three (cadmium, copper and sodium arsenite) were active in all five cell lines.	sodium arsenite	249-264	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
20965206-0	2011	Sodium arsenite delays the differentiation of C2C12 mouse myoblast cells and alters methylation patterns on the transcription factor myogenin.	sodium arsenite	0-15	myogenin	Mus musculus	133-141
20965206-4	2011	Exposing C2C12 cells to 20 nM sodium arsenite delayed the differentiation process, as evidenced by a significant reduction in the number of multinucleated myotubes, a decrease in myogenin mRNA expression, and a decrease in the total number of nuclei expressing myogenin protein.	sodium arsenite	30-45	myogenin	Mus musculus	179-187
20965206-4	2011	Exposing C2C12 cells to 20 nM sodium arsenite delayed the differentiation process, as evidenced by a significant reduction in the number of multinucleated myotubes, a decrease in myogenin mRNA expression, and a decrease in the total number of nuclei expressing myogenin protein.	sodium arsenite	30-45	myogenin	Mus musculus	261-269
20965206-9	2011	This study indicates that 20 nM sodium arsenite can alter myoblast differentiation by reducing the expression of the transcription factors myogenin and Mef2c, which is likely due to changes in promoter methylation patterns.	sodium arsenite	32-47	myogenin	Mus musculus	139-147
20965206-9	2011	This study indicates that 20 nM sodium arsenite can alter myoblast differentiation by reducing the expression of the transcription factors myogenin and Mef2c, which is likely due to changes in promoter methylation patterns.	sodium arsenite	32-47	myocyte enhancer factor 2C	Mus musculus	152-157
22102309-4	2011	We have previously employed an in vitro model system of human epidermal keratinocytes to study the effects of submicromolar concentrations of sodium arsenite on cyclin D1 expression.	sodium arsenite	142-157	cyclin D1	Homo sapiens	161-170
19733843-5	2010	CD1 male mice were treated with different concentrations (0, 2.5, 5 or 10mg/kg/day) of sodium arsenite during 1, 3 or 9 days.	sodium arsenite	87-102	CD1 antigen complex	Mus musculus	0-3
19826909-2	2010	Splenocytes harvested in presence of sodium arsenite expressed Heat shock protein 70 (HSP 70) which could be identified on the basis of relative migration pattern and western blot analysis.	sodium arsenite	37-52	heat shock protein family A (Hsp70) member 2	Gallus gallus	63-84
19826909-2	2010	Splenocytes harvested in presence of sodium arsenite expressed Heat shock protein 70 (HSP 70) which could be identified on the basis of relative migration pattern and western blot analysis.	sodium arsenite	37-52	heat shock protein family A (Hsp70) member 2	Gallus gallus	86-92
19826909-3	2010	Serum levels of HSP 70 in broiler chicken also increased after continuous feeding of sodium arsenite in drinking water.	sodium arsenite	85-100	heat shock protein family A (Hsp70) member 2	Gallus gallus	16-22
19826909-5	2010	In vitro relative quantification of transcription level of HSP 70 revealed that splenocytes harvested in presence of sodium arsenite expressed (final concentration 3 and 7 muM/ml) more HSP 70 in comparison to cells harvested without sodium arsenite and the values were statistically significant (P < 0.001) when compared to untreated control.	sodium arsenite	117-132	heat shock protein family A (Hsp70) member 2	Gallus gallus	59-65
19826909-5	2010	In vitro relative quantification of transcription level of HSP 70 revealed that splenocytes harvested in presence of sodium arsenite expressed (final concentration 3 and 7 muM/ml) more HSP 70 in comparison to cells harvested without sodium arsenite and the values were statistically significant (P < 0.001) when compared to untreated control.	sodium arsenite	117-132	heat shock protein family A (Hsp70) member 2	Gallus gallus	185-191
20144955-3	2010	Administration of sodium arsenite (100 mg/kg/day) for 28 days in Sprague Dawley female rats resulted in significant reduction of biochemical parameters such as delta-aminolevulinic acid dehydratase (ALAD), reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and elevation of thiobarbituric acid reactive substances (TBARS) and the index of nitrite/nitrate (NOx) levels.	sodium arsenite	18-33	aminolevulinate dehydratase	Rattus norvegicus	160-197
20144955-3	2010	Administration of sodium arsenite (100 mg/kg/day) for 28 days in Sprague Dawley female rats resulted in significant reduction of biochemical parameters such as delta-aminolevulinic acid dehydratase (ALAD), reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and elevation of thiobarbituric acid reactive substances (TBARS) and the index of nitrite/nitrate (NOx) levels.	sodium arsenite	18-33	aminolevulinate dehydratase	Rattus norvegicus	199-203
20144955-5	2010	Green tea crude fraction (GTC) co-treated with sodium arsenite for 28 days caused significant (p < .01) elevation of ALAD, GSH, GPx, SOD, and nitrate/nitrite levels and reduction of the TBARS level and tissue burden when compared to detannified green tea fraction (GTDT)-treated groups.	sodium arsenite	47-62	aminolevulinate dehydratase	Rattus norvegicus	120-124
20980392-7	2010	Furthermore, DNA-damage-inducing agents doxorubicin, etoposide and sodium arsenite induced ferritin H mRNA expression in HIPK2(+/+) MEF cells, whereas it was significantly impaired in HIPK2(-/-) MEF cells.	sodium arsenite	67-82	homeodomain interacting protein kinase 2	Homo sapiens	121-126
20980392-7	2010	Furthermore, DNA-damage-inducing agents doxorubicin, etoposide and sodium arsenite induced ferritin H mRNA expression in HIPK2(+/+) MEF cells, whereas it was significantly impaired in HIPK2(-/-) MEF cells.	sodium arsenite	67-82	homeodomain interacting protein kinase 2	Homo sapiens	184-189
20422371-1	2010	The present study has been designed to investigate the effect of rosiglitazone, a peroxisome proliferator activated receptor gamma agonist in sodium arsenite-induced vascular endothelial dysfunction (VED) in rats.	sodium arsenite	142-157	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	82-130
20207026-3	2010	Since arsenic exposure prevents acclimation to seawater by decreasing CFTR protein levels we tested the hypothesis that arsenic (as sodium arsenite) blocks acclimation to seawater by down regulating SGK1 expression.	sodium arsenite	132-147	serine/threonine-protein kinase Sgk1	Fundulus heteroclitus	199-203
20188806-3	2010	The results showed that folate deficiency significantly aggravated the NaAsO(2)-induced apoptotic progression [evidenced by phosphatidylserine externalization, cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP), collapse of mitochondrial potential, and release of cytochrome c from the mitochondria] and decrease of cell viability.	sodium arsenite	71-79	caspase 3	Homo sapiens	172-214
20188806-3	2010	The results showed that folate deficiency significantly aggravated the NaAsO(2)-induced apoptotic progression [evidenced by phosphatidylserine externalization, cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP), collapse of mitochondrial potential, and release of cytochrome c from the mitochondria] and decrease of cell viability.	sodium arsenite	71-79	poly(ADP-ribose) polymerase 1	Homo sapiens	216-220
20188806-3	2010	The results showed that folate deficiency significantly aggravated the NaAsO(2)-induced apoptotic progression [evidenced by phosphatidylserine externalization, cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP), collapse of mitochondrial potential, and release of cytochrome c from the mitochondria] and decrease of cell viability.	sodium arsenite	71-79	cytochrome c, somatic	Homo sapiens	275-287
20083128-4	2010	The present study investigates the role of heme oxygenase-1 (HO-1) in sodium arsenite-mediated angiogenesis in vitro.	sodium arsenite	70-85	heme oxygenase 1	Homo sapiens	43-59
20083128-4	2010	The present study investigates the role of heme oxygenase-1 (HO-1) in sodium arsenite-mediated angiogenesis in vitro.	sodium arsenite	70-85	heme oxygenase 1	Homo sapiens	61-65
20028703-1	2010	Sodium arsenite-exposed hepatocytes of rat showed higher production of nitric oxide (NO) and increased lipid peroxidation (LPO) level vis-a-vis activity of superoxide dismutase (SOD) and catalase (CAT) were significantly lowered.	sodium arsenite	0-15	catalase	Rattus norvegicus	187-195
20028703-1	2010	Sodium arsenite-exposed hepatocytes of rat showed higher production of nitric oxide (NO) and increased lipid peroxidation (LPO) level vis-a-vis activity of superoxide dismutase (SOD) and catalase (CAT) were significantly lowered.	sodium arsenite	0-15	catalase	Rattus norvegicus	197-200
20008137-1	2010	Sodium arsenite (NaAs)-induced autophagic cell death (ACD) of a mouse renal tubular epithelial cell line (mProx24), which expresses enhanced levels of interleukin-6 (IL-6), was reduced by the suppression of autophagy by 3-methyladenine or Atg7 knockdown.	sodium arsenite	0-15	interleukin 6	Mus musculus	151-164
20008137-1	2010	Sodium arsenite (NaAs)-induced autophagic cell death (ACD) of a mouse renal tubular epithelial cell line (mProx24), which expresses enhanced levels of interleukin-6 (IL-6), was reduced by the suppression of autophagy by 3-methyladenine or Atg7 knockdown.	sodium arsenite	0-15	interleukin 6	Mus musculus	166-170
20008137-1	2010	Sodium arsenite (NaAs)-induced autophagic cell death (ACD) of a mouse renal tubular epithelial cell line (mProx24), which expresses enhanced levels of interleukin-6 (IL-6), was reduced by the suppression of autophagy by 3-methyladenine or Atg7 knockdown.	sodium arsenite	0-15	autophagy related 7	Mus musculus	239-243
19577553-0	2009	Sodium arsenite-induced DAPK promoter hypermethylation and autophagy via ERK1/2 phosphorylation in human uroepithelial cells.	sodium arsenite	0-15	death associated protein kinase 1	Homo sapiens	24-28
20146381-1	2010	This study evaluated the involvement of hypophyseal-gonadal and hypophyseal-adrenal axes as a possible mechanism of sodium arsenite toxicity in ovary and uterus by the coadministration of hCG.	sodium arsenite	116-131	chorionic gonadotropin subunit beta 5	Homo sapiens	188-191
20146381-2	2010	Subchronic treatment of 0.4 ppm of sodium arsenite/(100 g body weight day) via drinking water for seven estrous cycles significantly suppressed the plasma levels of leutinizing hormone, follicle-stimulating hormone, and estradiol along with sluggish ovarian activities of Delta(5),3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase followed by a reduction in gonadal tissue peroxidase activities in mature female rats at diestrous phase.	sodium arsenite	35-50	aldo-keto reductase family 1, member C12	Rattus norvegicus	320-355
19536524-3	2009	NaAsO2 treatment (0-30 microM) was also found to induce phosphatidylserine externalization, a hallmark of apoptosis; to disrupt the mitochondrial membrane potential (Deltapsi ( m )); to cause the release of cytochrome c into the cytosol, and to trigger cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in a dose-dependent manner.	sodium arsenite	0-6	cytochrome c, somatic	Homo sapiens	207-219
19766132-0	2009	Sodium arsenite alters cell cycle and MTHFR, MT1/2, and c-Myc protein levels in MCF-7 cells.	sodium arsenite	0-15	methylenetetrahydrofolate reductase	Homo sapiens	38-43
19766132-0	2009	Sodium arsenite alters cell cycle and MTHFR, MT1/2, and c-Myc protein levels in MCF-7 cells.	sodium arsenite	0-15	metallothionein 1I, pseudogene	Homo sapiens	45-50
19766132-0	2009	Sodium arsenite alters cell cycle and MTHFR, MT1/2, and c-Myc protein levels in MCF-7 cells.	sodium arsenite	0-15	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	56-61
19766132-2	2009	Therefore, our aim was to evaluate the effects of sodium arsenite on the protein levels of methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) and its further relationship with the expression MT1/2 and c-myc in MCF-7 cells.	sodium arsenite	50-65	methylenetetrahydrofolate reductase	Homo sapiens	91-126
19766132-2	2009	Therefore, our aim was to evaluate the effects of sodium arsenite on the protein levels of methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) and its further relationship with the expression MT1/2 and c-myc in MCF-7 cells.	sodium arsenite	50-65	methylenetetrahydrofolate reductase	Homo sapiens	128-133
19766132-2	2009	Therefore, our aim was to evaluate the effects of sodium arsenite on the protein levels of methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) and its further relationship with the expression MT1/2 and c-myc in MCF-7 cells.	sodium arsenite	50-65	dihydrofolate reductase	Homo sapiens	139-162
19766132-2	2009	Therefore, our aim was to evaluate the effects of sodium arsenite on the protein levels of methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) and its further relationship with the expression MT1/2 and c-myc in MCF-7 cells.	sodium arsenite	50-65	dihydrofolate reductase	Homo sapiens	164-168
19766132-2	2009	Therefore, our aim was to evaluate the effects of sodium arsenite on the protein levels of methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) and its further relationship with the expression MT1/2 and c-myc in MCF-7 cells.	sodium arsenite	50-65	metallothionein 1I, pseudogene	Homo sapiens	219-224
19766132-2	2009	Therefore, our aim was to evaluate the effects of sodium arsenite on the protein levels of methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) and its further relationship with the expression MT1/2 and c-myc in MCF-7 cells.	sodium arsenite	50-65	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	229-234
19536524-3	2009	NaAsO2 treatment (0-30 microM) was also found to induce phosphatidylserine externalization, a hallmark of apoptosis; to disrupt the mitochondrial membrane potential (Deltapsi ( m )); to cause the release of cytochrome c into the cytosol, and to trigger cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in a dose-dependent manner.	sodium arsenite	0-6	caspase 3	Homo sapiens	265-307
19536524-3	2009	NaAsO2 treatment (0-30 microM) was also found to induce phosphatidylserine externalization, a hallmark of apoptosis; to disrupt the mitochondrial membrane potential (Deltapsi ( m )); to cause the release of cytochrome c into the cytosol, and to trigger cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in a dose-dependent manner.	sodium arsenite	0-6	poly(ADP-ribose) polymerase 1	Homo sapiens	309-313
19577553-0	2009	Sodium arsenite-induced DAPK promoter hypermethylation and autophagy via ERK1/2 phosphorylation in human uroepithelial cells.	sodium arsenite	0-15	mitogen-activated protein kinase 3	Homo sapiens	73-79
19672740-3	2009	Investigating the responsible signalling cascades, it was found that NaAsO(2) administration activates mitogen-activated protein kinases (MAPKs) and NF-kappaB in oxidative stress mediated renal dysfunction and induced apoptotic cell death by the reciprocal regulation of Bcl-2/Bad in association with reducing mitochondrial membrane potential and increased cytosolic cytochrome C as well.	sodium arsenite	69-77	nuclear factor kappa B subunit 1	Homo sapiens	149-158
19672740-3	2009	Investigating the responsible signalling cascades, it was found that NaAsO(2) administration activates mitogen-activated protein kinases (MAPKs) and NF-kappaB in oxidative stress mediated renal dysfunction and induced apoptotic cell death by the reciprocal regulation of Bcl-2/Bad in association with reducing mitochondrial membrane potential and increased cytosolic cytochrome C as well.	sodium arsenite	69-77	BCL2 apoptosis regulator	Homo sapiens	271-276
19672740-3	2009	Investigating the responsible signalling cascades, it was found that NaAsO(2) administration activates mitogen-activated protein kinases (MAPKs) and NF-kappaB in oxidative stress mediated renal dysfunction and induced apoptotic cell death by the reciprocal regulation of Bcl-2/Bad in association with reducing mitochondrial membrane potential and increased cytosolic cytochrome C as well.	sodium arsenite	69-77	cytochrome c, somatic	Homo sapiens	367-379
19084030-5	2009	The present study investigates the effect of sodium arsenite and its metabolites monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III)) on CYP3A4, PXR, and RXR alpha expression in the small intestine of CYP3A4 transgenic mice.	sodium arsenite	45-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	220-226
19575768-8	2009	The metalloid sodium arsenite induces skn-1-dependent activation of certain detoxification gene groups, including some that were not SKN-1-upregulated under normal conditions.	sodium arsenite	14-29	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	38-43
19084030-5	2009	The present study investigates the effect of sodium arsenite and its metabolites monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III)) on CYP3A4, PXR, and RXR alpha expression in the small intestine of CYP3A4 transgenic mice.	sodium arsenite	45-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	156-162
19084030-5	2009	The present study investigates the effect of sodium arsenite and its metabolites monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III)) on CYP3A4, PXR, and RXR alpha expression in the small intestine of CYP3A4 transgenic mice.	sodium arsenite	45-60	nuclear receptor subfamily 1, group I, member 2	Mus musculus	164-167
19084030-5	2009	The present study investigates the effect of sodium arsenite and its metabolites monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III)) on CYP3A4, PXR, and RXR alpha expression in the small intestine of CYP3A4 transgenic mice.	sodium arsenite	45-60	retinoid X receptor alpha	Mus musculus	173-182
19084030-6	2009	Sodium arsenite treatment increases mRNA, protein and CYP3A4 activity in a dose-dependent manner.	sodium arsenite	0-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	54-60
19084030-10	2009	Sodium arsenite and both its metabolites increase PXR mRNA, while only DMA(III) induces RXR alpha expression.	sodium arsenite	0-15	nuclear receptor subfamily 1, group I, member 2	Mus musculus	50-53
19084030-11	2009	Overall, these results suggest that sodium arsenite and its metabolites induce CYP3A4 expression by increasing PXR expression in the small intestine of CYP3A4 transgenic mice.	sodium arsenite	36-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	79-85
19084030-11	2009	Overall, these results suggest that sodium arsenite and its metabolites induce CYP3A4 expression by increasing PXR expression in the small intestine of CYP3A4 transgenic mice.	sodium arsenite	36-51	nuclear receptor subfamily 1, group I, member 2	Mus musculus	111-114
19084030-11	2009	Overall, these results suggest that sodium arsenite and its metabolites induce CYP3A4 expression by increasing PXR expression in the small intestine of CYP3A4 transgenic mice.	sodium arsenite	36-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	152-158
19580012-8	2009	The three single doses of sodium arsenite alone significantly (p<0.05) increased the rate of total structural Chromosomal Aberrations (CAs), rate of Sister Chromatid Exchanges (SCEs), micronucleus (MNs) formation, PARP and Lamia-A degradation and apoptosis as compared with the negative control.	sodium arsenite	26-41	poly (ADP-ribose) polymerase family, member 1	Mus musculus	217-221
19358893-0	2009	Simultaneous exposure of Xenopus A6 kidney epithelial cells to concurrent mild sodium arsenite and heat stress results in enhanced hsp30 and hsp70 gene expression and the acquisition of thermotolerance.	sodium arsenite	79-94	heat shock protein 30E L homeolog	Xenopus laevis	131-136
19358893-0	2009	Simultaneous exposure of Xenopus A6 kidney epithelial cells to concurrent mild sodium arsenite and heat stress results in enhanced hsp30 and hsp70 gene expression and the acquisition of thermotolerance.	sodium arsenite	79-94	heat shock 70kDa protein L homeolog	Xenopus laevis	141-146
19358893-1	2009	In this study, we examined the effect of concurrent low concentrations of sodium arsenite and mild heat shock temperatures on hsp30 and hsp70 gene expression in Xenopus A6 kidney epithelial cells.	sodium arsenite	74-89	heat shock protein 30E L homeolog	Xenopus laevis	126-131
19358893-1	2009	In this study, we examined the effect of concurrent low concentrations of sodium arsenite and mild heat shock temperatures on hsp30 and hsp70 gene expression in Xenopus A6 kidney epithelial cells.	sodium arsenite	74-89	heat shock 70kDa protein L homeolog	Xenopus laevis	136-141
19358893-2	2009	RNA blot hybridization and immunoblot analysis revealed that exposure of A6 cells to 1-10 microM sodium arsenite at a mild heat shock temperature of 30 degrees C enhanced hsp30 and hsp70 gene expression to a much greater extent than found with either stress individually.	sodium arsenite	97-112	heat shock protein 30E L homeolog	Xenopus laevis	171-176
19358893-2	2009	RNA blot hybridization and immunoblot analysis revealed that exposure of A6 cells to 1-10 microM sodium arsenite at a mild heat shock temperature of 30 degrees C enhanced hsp30 and hsp70 gene expression to a much greater extent than found with either stress individually.	sodium arsenite	97-112	heat shock 70kDa protein L homeolog	Xenopus laevis	181-186
19358893-3	2009	In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation.	sodium arsenite	47-62	heat shock protein 30E L homeolog	Xenopus laevis	127-132
19358893-3	2009	In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation.	sodium arsenite	47-62	heat shock 70kDa protein L homeolog	Xenopus laevis	137-150
19358893-3	2009	In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation.	sodium arsenite	47-62	heat shock factor protein	Xenopus laevis	232-236
19358893-3	2009	In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation.	sodium arsenite	47-62	heat shock factor protein	Xenopus laevis	316-320
19358893-3	2009	In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation.	sodium arsenite	47-62	heat shock protein 30E L homeolog	Xenopus laevis	361-366
19358893-3	2009	In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation.	sodium arsenite	47-62	heat shock 70kDa protein L homeolog	Xenopus laevis	137-142
18996220-0	2009	Sodium arsenite induces ROS generation, DNA oxidative damage, HO-1 and c-Myc proteins, NF-kappaB activation and cell proliferation in human breast cancer MCF-7 cells.	sodium arsenite	0-15	heme oxygenase 1	Homo sapiens	62-66
18996220-0	2009	Sodium arsenite induces ROS generation, DNA oxidative damage, HO-1 and c-Myc proteins, NF-kappaB activation and cell proliferation in human breast cancer MCF-7 cells.	sodium arsenite	0-15	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	71-76
18606238-3	2008	Immunoblot analysis, using a homologous antibody, detected the presence of HSP110 in A6 cells maintained at 22 degrees C. The relative levels of HSP110 accumulation increased after heat shock or sodium arsenite treatment.	sodium arsenite	195-210	heat shock protein family H (Hsp110) member 1 S homeolog	Xenopus laevis	75-81
19010883-2	2008	We report here that treatment of cells with sodium arsenite at the concentrations close to environmental exposure is associated with the up-regulation of Hdm2 and the accumulation of p53 in the cytoplasm.	sodium arsenite	44-59	MDM2 proto-oncogene	Homo sapiens	154-158
19010883-2	2008	We report here that treatment of cells with sodium arsenite at the concentrations close to environmental exposure is associated with the up-regulation of Hdm2 and the accumulation of p53 in the cytoplasm.	sodium arsenite	44-59	tumor protein p53	Homo sapiens	183-186
18809455-6	2008	The activity of brain and plasma acetylcholinesterase (AChE) was decreased in rats treated with Sa.	sodium arsenite	96-98	acetylcholinesterase	Rattus norvegicus	55-59
18809455-7	2008	Also, Sa significantly decreased plasma total protein (TP), albumin (Alb) and high density lipoprotein-cholesterol (HDL-c), while increased glucose, urea, creatinine, bilirubin, total lipid (TL), cholesterol, triglyceride (TG) and low density lipoprotein-cholesterol (LDL-c).	sodium arsenite	6-8	albumin	Rattus norvegicus	60-67
18809455-7	2008	Also, Sa significantly decreased plasma total protein (TP), albumin (Alb) and high density lipoprotein-cholesterol (HDL-c), while increased glucose, urea, creatinine, bilirubin, total lipid (TL), cholesterol, triglyceride (TG) and low density lipoprotein-cholesterol (LDL-c).	sodium arsenite	6-8	albumin	Rattus norvegicus	69-72
18675372-4	2008	In A6 cells subjected to sodium arsenite, cadmium chloride, herbimycin A or a 33 degrees C heat shock treatment, immunocytochemistry and confocal microscopy revealed that HSP30 accumulated primarily in the cytoplasm.	sodium arsenite	25-40	heat shock protein 30E L homeolog	Xenopus laevis	171-176
18606238-3	2008	Immunoblot analysis, using a homologous antibody, detected the presence of HSP110 in A6 cells maintained at 22 degrees C. The relative levels of HSP110 accumulation increased after heat shock or sodium arsenite treatment.	sodium arsenite	195-210	heat shock protein family H (Hsp110) member 1 S homeolog	Xenopus laevis	145-151
18606238-8	2008	Finally, A6 cells treated with 25 microM sodium arsenite produced very dense HSP110 structures primarily in the cytoplasm while HSP30 was enriched in the cytoplasm in a granular pattern.	sodium arsenite	41-56	heat shock protein family H (Hsp110) member 1 S homeolog	Xenopus laevis	77-83
18505831-10	2008	Results from our study suggest that sodium arsenite induces SHP via AMPK to inhibit the expression of hepatic gluconeogenic genes and also provide us with a novel molecular mechanism of arsenite-mediated regulation of hepatic glucose homeostasis.	sodium arsenite	36-51	nuclear receptor subfamily 0 group B member 2	Homo sapiens	60-63
18501396-0	2008	Mitotic arrest-associated apoptosis induced by sodium arsenite in A375 melanoma cells is BUBR1-dependent.	sodium arsenite	47-62	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	89-94
18505831-10	2008	Results from our study suggest that sodium arsenite induces SHP via AMPK to inhibit the expression of hepatic gluconeogenic genes and also provide us with a novel molecular mechanism of arsenite-mediated regulation of hepatic glucose homeostasis.	sodium arsenite	36-51	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	68-72
18505831-0	2008	Sodium arsenite induces orphan nuclear receptor SHP gene expression via AMP-activated protein kinase to inhibit gluconeogenic enzyme gene expression.	sodium arsenite	0-15	nuclear receptor subfamily 0 group B member 2	Homo sapiens	31-51
17999076-0	2008	Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells.	sodium arsenite	0-15	histone deacetylase 9	Homo sapiens	47-66
18505831-2	2008	In this study, we report that the sodium arsenite-induced gene expression of the small heterodimer partner (SHP; NR0B2), an atypical orphan nuclear receptor, regulates the expression of hepatic gluconeogenic genes.	sodium arsenite	34-49	nuclear receptor subfamily 0 group B member 2	Homo sapiens	81-106
18505831-2	2008	In this study, we report that the sodium arsenite-induced gene expression of the small heterodimer partner (SHP; NR0B2), an atypical orphan nuclear receptor, regulates the expression of hepatic gluconeogenic genes.	sodium arsenite	34-49	nuclear receptor subfamily 0 group B member 2	Homo sapiens	108-111
18505831-2	2008	In this study, we report that the sodium arsenite-induced gene expression of the small heterodimer partner (SHP; NR0B2), an atypical orphan nuclear receptor, regulates the expression of hepatic gluconeogenic genes.	sodium arsenite	34-49	nuclear receptor subfamily 0 group B member 2	Homo sapiens	113-118
18505831-3	2008	Sodium arsenite augments hepatic SHP mRNA levels in an AMP-activated protein kinase (AMPK)-dependent manner.	sodium arsenite	0-15	nuclear receptor subfamily 0 group B member 2	Homo sapiens	33-36
18505831-3	2008	Sodium arsenite augments hepatic SHP mRNA levels in an AMP-activated protein kinase (AMPK)-dependent manner.	sodium arsenite	0-15	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	85-89
18505831-4	2008	Sodium arsenite activated AMPK and was shown to perturb cellular ATP levels.	sodium arsenite	0-15	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	26-30
18505831-6	2008	We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase).	sodium arsenite	67-82	nuclear receptor subfamily 0 group B member 2	Homo sapiens	48-51
18505831-6	2008	We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase).	sodium arsenite	67-82	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	188-221
18505831-6	2008	We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase).	sodium arsenite	67-82	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	223-228
18505831-6	2008	We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase).	sodium arsenite	67-82	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	234-255
18505831-6	2008	We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase).	sodium arsenite	67-82	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	257-263
18505831-8	2008	Sodium arsenite inhibited the promoter activity of PEPCK and G6Pase, and this repression was abolished by small interfering (si)RNA SHP treatments.	sodium arsenite	0-15	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	51-56
18505831-8	2008	Sodium arsenite inhibited the promoter activity of PEPCK and G6Pase, and this repression was abolished by small interfering (si)RNA SHP treatments.	sodium arsenite	0-15	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	61-67
18505831-8	2008	Sodium arsenite inhibited the promoter activity of PEPCK and G6Pase, and this repression was abolished by small interfering (si)RNA SHP treatments.	sodium arsenite	0-15	nuclear receptor subfamily 0 group B member 2	Homo sapiens	132-135
18505831-9	2008	The knockdown of SHP expression by oligonucleotide siRNA SHP or adenoviral siRNA SHP released the sodium arsenite-mediated repression of forskolin/dexamethasone-stimulated PEPCK and G6Pase gene expression in a variety of hepatic cell lines.	sodium arsenite	98-113	nuclear receptor subfamily 0 group B member 2	Homo sapiens	17-20
18505831-9	2008	The knockdown of SHP expression by oligonucleotide siRNA SHP or adenoviral siRNA SHP released the sodium arsenite-mediated repression of forskolin/dexamethasone-stimulated PEPCK and G6Pase gene expression in a variety of hepatic cell lines.	sodium arsenite	98-113	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	172-177
18505831-9	2008	The knockdown of SHP expression by oligonucleotide siRNA SHP or adenoviral siRNA SHP released the sodium arsenite-mediated repression of forskolin/dexamethasone-stimulated PEPCK and G6Pase gene expression in a variety of hepatic cell lines.	sodium arsenite	98-113	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	182-188
18417180-3	2008	Previously, we reported that activation of the Nrf2-mediated cellular defense pathway confers protection against toxic effects induced by sodium arsenite [As(III)] or monomethylarsonous acid [MMA(III)].	sodium arsenite	138-153	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
18476811-4	2008	Phosphorylation of Ago2 at serine-387 was significantly induced by treatment with sodium arsenite or anisomycin, and arsenite-induced phosphorylation was inhibited by a p38 MAPK (mitogen-activated protein kinase) inhibitor, but not by inhibitors of JNK (c-Jun N-terminal kinase) or MEK [MAPK/ERK (extracellular-signal-regulated kinase) kinase].	sodium arsenite	82-97	argonaute RISC catalytic component 2	Homo sapiens	19-23
18407307-3	2008	Intra-gastric exposure to arsenic (as sodium arsenite) for 30 days (1, 0.1, or 0.01 mg/kg/day), reduced the proportion of CD4+ cells and the CD4+/CD8+ ratio in the spleen, increasing the proportion of CD11b+ cells.	sodium arsenite	38-53	integrin subunit alpha M	Homo sapiens	201-206
18465250-1	2008	Sodium arsenite induces apoptosis in PC12 cells by activating the stress-activated p38 MAP kinase and the pro-apoptotic Bcl-2 family protein Bim(EL).	sodium arsenite	0-15	mitogen activated protein kinase 14	Rattus norvegicus	83-86
18465250-1	2008	Sodium arsenite induces apoptosis in PC12 cells by activating the stress-activated p38 MAP kinase and the pro-apoptotic Bcl-2 family protein Bim(EL).	sodium arsenite	0-15	BCL2, apoptosis regulator	Rattus norvegicus	120-125
18465250-1	2008	Sodium arsenite induces apoptosis in PC12 cells by activating the stress-activated p38 MAP kinase and the pro-apoptotic Bcl-2 family protein Bim(EL).	sodium arsenite	0-15	Bcl2-like 11	Rattus norvegicus	141-144
18465250-3	2008	Here, we report that sodium arsenite stimulates the protein expression and promoter activity of Bim(EL) in a p38-dependent manner.	sodium arsenite	21-36	Bcl2-like 11	Rattus norvegicus	96-99
18465250-3	2008	Here, we report that sodium arsenite stimulates the protein expression and promoter activity of Bim(EL) in a p38-dependent manner.	sodium arsenite	21-36	mitogen activated protein kinase 14	Rattus norvegicus	109-112
18465250-4	2008	Sodium arsenite also caused nuclear translocation of FOXO3a, indicative of FOXO3a activation.	sodium arsenite	0-15	forkhead box O3	Rattus norvegicus	53-59
18465250-4	2008	Sodium arsenite also caused nuclear translocation of FOXO3a, indicative of FOXO3a activation.	sodium arsenite	0-15	forkhead box O3	Rattus norvegicus	75-81
17999076-9	2008	Thus, our data suggest that NaAsO(2) induces chromatin opening by histone hyperacetylation due to HDAC inhibition and increase of the mobility of nucleosome-associated proteins.	sodium arsenite	28-36	histone deacetylase 9	Homo sapiens	98-102
17941083-0	2008	Sodium arsenite induces heat shock protein 70 expression and protects against secretagogue-induced trypsinogen and NF-kappaB activation.	sodium arsenite	0-15	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	24-45
18404528-1	2008	Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells.	sodium arsenite	51-66	heme oxygenase 1	Mus musculus	0-16
18404528-1	2008	Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells.	sodium arsenite	51-66	heme oxygenase 1	Mus musculus	18-22
18404528-1	2008	Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells.	sodium arsenite	51-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	129-133
18404528-1	2008	Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells.	sodium arsenite	51-66	heme oxygenase 1	Mus musculus	163-167
17941083-5	2008	Our results showed that sodium arsenite pretreatment induced HSP70 expression both in vitro and in vivo and significantly ameliorated the severity of cerulein-induced pancreatitis, as evidenced by the markedly reduced degree of hyperamylasemia, pancreatic edema, and acinar cell necrosis.	sodium arsenite	24-39	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	61-66
17941083-6	2008	Sodium arsenite pretreatment not only inhibited trypsinogen activation and the subcellular redistribution of cathepsin B, but also prevented NF-kappaB translocation to the nucleus by inhibiting the IkappaBalpha degradation both in vivo and in vitro.	sodium arsenite	0-15	cathepsin B	Rattus norvegicus	109-120
17941083-6	2008	Sodium arsenite pretreatment not only inhibited trypsinogen activation and the subcellular redistribution of cathepsin B, but also prevented NF-kappaB translocation to the nucleus by inhibiting the IkappaBalpha degradation both in vivo and in vitro.	sodium arsenite	0-15	NFKB inhibitor alpha	Rattus norvegicus	198-210
17941083-8	2008	Based on our observations we conclude that, like thermal stress, chemical stressors such as sodium arsenite also induce HSP70 expression in the pancreas and protect against acute pancreatitis.	sodium arsenite	92-107	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	120-125
18191166-0	2008	Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite.	sodium arsenite	91-106	keratin 6	Mus musculus	68-74
17804168-0	2008	Induction of heat shock protein 70 by sodium arsenite attenuates burn-induced intestinal injury in severe burned rats.	sodium arsenite	38-53	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	13-34
18197399-5	2008	Oral administration of NaAsO2 at a dose of 10 mg/kg body weight for 2 days caused significant accumulation of arsenic in cardiac tissues of the experimental mice in association with the reduction in cardiac antioxidant enzymes activities, namely superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase.	sodium arsenite	23-29	catalase	Mus musculus	268-276
18197399-5	2008	Oral administration of NaAsO2 at a dose of 10 mg/kg body weight for 2 days caused significant accumulation of arsenic in cardiac tissues of the experimental mice in association with the reduction in cardiac antioxidant enzymes activities, namely superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase.	sodium arsenite	23-29	hematopoietic prostaglandin D synthase	Mus musculus	278-303
18197399-5	2008	Oral administration of NaAsO2 at a dose of 10 mg/kg body weight for 2 days caused significant accumulation of arsenic in cardiac tissues of the experimental mice in association with the reduction in cardiac antioxidant enzymes activities, namely superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase.	sodium arsenite	23-29	glutathione reductase	Mus musculus	305-326
18222423-5	2008	Interestingly, resveratrol did not increase surface expression of DR5 in human melanomas, while gamma-irradiation or sodium arsenite treatment substantially upregulated DR5 expression.	sodium arsenite	117-132	TNF receptor superfamily member 10b	Homo sapiens	169-172
17983699-5	2008	Moreover, AGE application in NaAsO(2) intoxicated Sprague-Dawley rats resulted in a marked inhibition of tissue lipid peroxide generation; enhanced level of total tissue sulfhydryl groups and glutathione; and also increased the activities of antioxidant enzymes, superoxide dismutase and catalase to near normal.	sodium arsenite	29-37	catalase	Rattus norvegicus	288-296
17938202-2	2007	We investigated expression of the essential base excision DNA repair enzyme apurinic endonuclease 1 (Ape1) in response to sodium arsenite.	sodium arsenite	122-137	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	101-105
18273903-5	2008	Oral administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly decreased the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase, the level of cellular metabolites, reduced glutathione, total thiols and increased the level of oxidized glutathione.	sodium arsenite	23-38	catalase	Mus musculus	169-177
18273903-5	2008	Oral administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly decreased the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase, the level of cellular metabolites, reduced glutathione, total thiols and increased the level of oxidized glutathione.	sodium arsenite	23-38	hematopoietic prostaglandin D synthase	Mus musculus	179-204
18273903-5	2008	Oral administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly decreased the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase, the level of cellular metabolites, reduced glutathione, total thiols and increased the level of oxidized glutathione.	sodium arsenite	23-38	glutathione reductase	Mus musculus	206-227
17984221-5	2008	PRTB was recruited to SG under sodium arsenite and heat stress conditions.	sodium arsenite	31-46	DAZ associated protein 2	Homo sapiens	0-4
17984221-7	2008	Knockdown of PRTB reduced the SG formation induced by sodium arsenite.	sodium arsenite	54-69	DAZ associated protein 2	Homo sapiens	13-17
17619074-5	2007	In addition, AGS-R cells were cross-resistant to sodium arsenite and hydrogen peroxide, indicating that tolerance to oxidative stress might play a role in the development of resistance described in this investigation.	sodium arsenite	49-64	jagged canonical Notch ligand 1	Homo sapiens	13-16
17945324-5	2007	These cells were treated with different doses of sodium arsenite (0, 0.1, 1, 5 and 10 microM) for 48 h. A greater reduction in cell viability was observed in the BEAS-2B cells vs. p53 compromised cells (H1355 or p53-inhibited BEAS-2B).	sodium arsenite	49-64	tumor protein p53	Homo sapiens	180-183
17945324-5	2007	These cells were treated with different doses of sodium arsenite (0, 0.1, 1, 5 and 10 microM) for 48 h. A greater reduction in cell viability was observed in the BEAS-2B cells vs. p53 compromised cells (H1355 or p53-inhibited BEAS-2B).	sodium arsenite	49-64	tumor protein p53	Homo sapiens	212-215
17910617-3	2007	Administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly reduced the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione S-transferase, glutathione reductase and glutathione peroxidase as well as depleted the level of reduced glutathione and total thiols.	sodium arsenite	18-33	catalase	Mus musculus	162-170
17910617-3	2007	Administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly reduced the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione S-transferase, glutathione reductase and glutathione peroxidase as well as depleted the level of reduced glutathione and total thiols.	sodium arsenite	18-33	hematopoietic prostaglandin D synthase	Mus musculus	172-197
17910617-3	2007	Administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly reduced the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione S-transferase, glutathione reductase and glutathione peroxidase as well as depleted the level of reduced glutathione and total thiols.	sodium arsenite	18-33	glutathione reductase	Mus musculus	199-220
17928125-3	2007	K6/ODC mice develop skin tumors when exposed to 10ppm sodium arsenite for 5 months.	sodium arsenite	54-69	ornithine decarboxylase, structural 1	Mus musculus	3-6
17906315-9	2007	Similarly, sodium arsenite stimulated a concentration-dependent increase in COX-2 expression.	sodium arsenite	11-26	prostaglandin-endoperoxide synthase 2	Homo sapiens	76-81
17906315-10	2007	In conclusion, this study demonstrated that sodium arsenite is genotoxic to uroepithelial cells in vitro, and that it will induce expression of mutant p53 and COX-2 proteins, indicating a possible key event in carcinogenesis.	sodium arsenite	44-59	tumor protein p53	Homo sapiens	151-154
17906315-10	2007	In conclusion, this study demonstrated that sodium arsenite is genotoxic to uroepithelial cells in vitro, and that it will induce expression of mutant p53 and COX-2 proteins, indicating a possible key event in carcinogenesis.	sodium arsenite	44-59	prostaglandin-endoperoxide synthase 2	Homo sapiens	159-164
17707572-6	2007	The sequencing of four arsenite-sensitive RAPD bands showed that the RB1CC1 and PACE4 genes might be the DNA targets of sodium arsenite treatment.	sodium arsenite	120-135	RB1 inducible coiled-coil 1	Homo sapiens	69-75
17707572-6	2007	The sequencing of four arsenite-sensitive RAPD bands showed that the RB1CC1 and PACE4 genes might be the DNA targets of sodium arsenite treatment.	sodium arsenite	120-135	proprotein convertase subtilisin/kexin type 6	Homo sapiens	80-85
17340120-3	2007	We have previously observed that sodium arsenite (SA) induced the synthesis of CK18 protein and promotes a dose-related disruption of cytoplasmic CK18 filaments in a human hepatic cell line.	sodium arsenite	33-48	keratin 18	Homo sapiens	79-83
17340120-3	2007	We have previously observed that sodium arsenite (SA) induced the synthesis of CK18 protein and promotes a dose-related disruption of cytoplasmic CK18 filaments in a human hepatic cell line.	sodium arsenite	33-48	keratin 18	Homo sapiens	146-150
17340120-3	2007	We have previously observed that sodium arsenite (SA) induced the synthesis of CK18 protein and promotes a dose-related disruption of cytoplasmic CK18 filaments in a human hepatic cell line.	sodium arsenite	50-52	keratin 18	Homo sapiens	79-83
17340120-3	2007	We have previously observed that sodium arsenite (SA) induced the synthesis of CK18 protein and promotes a dose-related disruption of cytoplasmic CK18 filaments in a human hepatic cell line.	sodium arsenite	50-52	keratin 18	Homo sapiens	146-150
17340120-8	2007	Increased expression of CK18 was observed after exposure to SA.	sodium arsenite	60-62	keratin 18	Mus musculus	24-28
17340120-11	2007	Mice treated with intragastric single doses of 2.5 and 5 mg/kg of SA showed an increased expression of CK18.	sodium arsenite	66-68	keratin 18	Mus musculus	103-107
17545621-8	2007	Moreover, sodium arsenite treatment may up-regulate expression of endogenous TRAIL and induces its translocation to cell surface and further down-regulates cFLIP levels in melanoma cells.	sodium arsenite	10-25	TNF superfamily member 10	Homo sapiens	77-82
17545210-4	2007	Immunoblotting reveals that a 3-h treatment of U937 cells with 5 microM sodium arsenite results in a dramatic decrease in cdc25A protein levels.	sodium arsenite	72-87	cell division cycle 25A	Homo sapiens	122-128
17467962-0	2007	Protective effects of hepatocellular canalicular conjugate export pump (Mrp2) on sodium arsenite-induced hepatic dysfunction in rats.	sodium arsenite	81-96	ATP binding cassette subfamily B member 4	Rattus norvegicus	72-76
17689208-0	2007	Expression of STAT3 and Bcl-6 oncoprotein in sodium arsenite-treated SV-40 immortalized human uroepithelial cells.	sodium arsenite	45-60	signal transducer and activator of transcription 3	Homo sapiens	14-19
17689208-0	2007	Expression of STAT3 and Bcl-6 oncoprotein in sodium arsenite-treated SV-40 immortalized human uroepithelial cells.	sodium arsenite	45-60	BCL6 transcription repressor	Homo sapiens	24-29
17689208-7	2007	Sodium arsenite treatment reduced Jak-2 protein expression in a dose-dependent manner.	sodium arsenite	0-15	Janus kinase 2	Homo sapiens	34-39
17545621-0	2007	Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells.	sodium arsenite	47-62	TNF superfamily member 10	Homo sapiens	88-93
17479414-4	2007	Results showed that sodium arsenite induced significant cell proliferation at low concentrations (0.5 microM for 12, 24, and 48 h), but inhibited cell growth at high amounts (5 and 10 microM for 24 and 48 h), reflected as a beta concentration-response curve.	sodium arsenite	20-35	amyloid beta precursor protein	Homo sapiens	222-228
17479414-8	2007	Similarly, heat-shock protein 27 (HSP27) levels were increased by sodium arsenite of low concentrations with early exposure time (3, 6, and 12 h), but decreased with high metal concentrations with greater exposure time (24 and 48 h).	sodium arsenite	66-81	heat shock protein family B (small) member 1	Homo sapiens	11-32
17479414-8	2007	Similarly, heat-shock protein 27 (HSP27) levels were increased by sodium arsenite of low concentrations with early exposure time (3, 6, and 12 h), but decreased with high metal concentrations with greater exposure time (24 and 48 h).	sodium arsenite	66-81	heat shock protein family B (small) member 1	Homo sapiens	34-39
17479414-9	2007	Sodium arsenite decreased HSP70 expression at lower concentrations, but increased HSP70 expression at higher concentration.	sodium arsenite	0-15	heat shock protein family A (Hsp70) member 4	Homo sapiens	26-31
17479414-9	2007	Sodium arsenite decreased HSP70 expression at lower concentrations, but increased HSP70 expression at higher concentration.	sodium arsenite	0-15	heat shock protein family A (Hsp70) member 4	Homo sapiens	82-87
17242398-6	2007	In the present study, HO-1 was induced by either sodium arsenite (reactive oxygen species producer) or hemin or overexpressed in the murine macrophage-like cell line, RAW 264.7.	sodium arsenite	49-64	heme oxygenase 1	Mus musculus	22-26
17096945-0	2006	[Effects of sodium arsenite on catalase in human keratinocytes].	sodium arsenite	12-27	catalase	Homo sapiens	31-39
17224793-6	2007	In addition, SA treatment decreased cytomix-induced NO production and inducible NO synthase mRNA expression and decreased the levels of STAT1, STAT3, SOCS1, and SOCS3.	sodium arsenite	13-15	nitric oxide synthase 2	Homo sapiens	70-91
17224793-6	2007	In addition, SA treatment decreased cytomix-induced NO production and inducible NO synthase mRNA expression and decreased the levels of STAT1, STAT3, SOCS1, and SOCS3.	sodium arsenite	13-15	signal transducer and activator of transcription 1	Homo sapiens	136-141
17224793-6	2007	In addition, SA treatment decreased cytomix-induced NO production and inducible NO synthase mRNA expression and decreased the levels of STAT1, STAT3, SOCS1, and SOCS3.	sodium arsenite	13-15	signal transducer and activator of transcription 3	Homo sapiens	143-148
17224793-6	2007	In addition, SA treatment decreased cytomix-induced NO production and inducible NO synthase mRNA expression and decreased the levels of STAT1, STAT3, SOCS1, and SOCS3.	sodium arsenite	13-15	suppressor of cytokine signaling 1	Homo sapiens	150-155
17224793-6	2007	In addition, SA treatment decreased cytomix-induced NO production and inducible NO synthase mRNA expression and decreased the levels of STAT1, STAT3, SOCS1, and SOCS3.	sodium arsenite	13-15	suppressor of cytokine signaling 3	Homo sapiens	161-166
17224793-7	2007	The SA treatment also decreased cytomix-induced IL-6 and IL-8 production in a dose-dependent manner.	sodium arsenite	4-6	interleukin 6	Homo sapiens	48-52
17224793-7	2007	The SA treatment also decreased cytomix-induced IL-6 and IL-8 production in a dose-dependent manner.	sodium arsenite	4-6	C-X-C motif chemokine ligand 8	Homo sapiens	57-61
17070520-0	2006	Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression.	sodium arsenite	0-15	TNF superfamily member 10	Homo sapiens	28-33
17070520-0	2006	Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression.	sodium arsenite	0-15	TNF receptor superfamily member 10a	Homo sapiens	95-103
17070520-0	2006	Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression.	sodium arsenite	0-15	CASP8 and FADD like apoptosis regulator	Homo sapiens	144-149
17070520-2	2006	Sodium arsenite is known to suppress both the IKK-NF-kappaB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis.	sodium arsenite	0-15	Janus kinase 2	Homo sapiens	64-68
17070520-2	2006	Sodium arsenite is known to suppress both the IKK-NF-kappaB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis.	sodium arsenite	0-15	signal transducer and activator of transcription 3	Homo sapiens	69-74
17070520-2	2006	Sodium arsenite is known to suppress both the IKK-NF-kappaB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis.	sodium arsenite	0-15	mitogen-activated protein kinase 8	Homo sapiens	119-122
17070520-2	2006	Sodium arsenite is known to suppress both the IKK-NF-kappaB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis.	sodium arsenite	0-15	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	123-127
17070520-5	2006	In the present study, we observed strong effects of sodium arsenite treatment on upregulation of TRAIL-mediated apoptosis in human and mouse melanomas.	sodium arsenite	52-67	TNF superfamily member 10	Homo sapiens	97-102
17070520-7	2006	Furthermore, activation of cJun and suppression of NF-kappaB by sodium arsenite resulted in upregulation of the endogenous TRAIL and downregulation of the cFLIP gene expression (which encodes one of the main anti-apoptotic proteins in melanomas) followed by cFLIP protein degradation and, finally, by acceleration of TRAIL-induced apoptosis.	sodium arsenite	64-79	TNF superfamily member 10	Homo sapiens	123-128
17070520-7	2006	Furthermore, activation of cJun and suppression of NF-kappaB by sodium arsenite resulted in upregulation of the endogenous TRAIL and downregulation of the cFLIP gene expression (which encodes one of the main anti-apoptotic proteins in melanomas) followed by cFLIP protein degradation and, finally, by acceleration of TRAIL-induced apoptosis.	sodium arsenite	64-79	CASP8 and FADD like apoptosis regulator	Homo sapiens	155-160
17070520-7	2006	Furthermore, activation of cJun and suppression of NF-kappaB by sodium arsenite resulted in upregulation of the endogenous TRAIL and downregulation of the cFLIP gene expression (which encodes one of the main anti-apoptotic proteins in melanomas) followed by cFLIP protein degradation and, finally, by acceleration of TRAIL-induced apoptosis.	sodium arsenite	64-79	CASP8 and FADD like apoptosis regulator	Homo sapiens	258-263
17070520-7	2006	Furthermore, activation of cJun and suppression of NF-kappaB by sodium arsenite resulted in upregulation of the endogenous TRAIL and downregulation of the cFLIP gene expression (which encodes one of the main anti-apoptotic proteins in melanomas) followed by cFLIP protein degradation and, finally, by acceleration of TRAIL-induced apoptosis.	sodium arsenite	64-79	TNF superfamily member 10	Homo sapiens	317-322
17005224-2	2006	To gain insight into the oncogenic properties of arsenic, we studied the expression of cyclin D1 in cultured human epidermal keratinocytes treated with submicromolar concentrations of sodium arsenite.	sodium arsenite	184-199	cyclin D1	Homo sapiens	87-96
17003472-0	2006	Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression.	sodium arsenite	43-58	interferon gamma	Mus musculus	0-16
17003472-0	2006	Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression.	sodium arsenite	43-58	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	108-149
16600567-0	2006	Effects of sodium arsenite on catalase activity, gene and protein expression in HaCaT cells.	sodium arsenite	11-26	catalase	Homo sapiens	30-38
16600567-1	2006	The objective of this research work is to study the effects of sodium arsenite on activity, mRNA and protein expression of catalase (CAT) in established human cell lines of keratinocytes (HaCaT).	sodium arsenite	63-78	catalase	Homo sapiens	123-131
16600567-1	2006	The objective of this research work is to study the effects of sodium arsenite on activity, mRNA and protein expression of catalase (CAT) in established human cell lines of keratinocytes (HaCaT).	sodium arsenite	63-78	catalase	Homo sapiens	133-136
16600567-4	2006	CAT activity, mRNA expression and protein levels were decreased by 5-20 micromol/l of sodium arsenite.	sodium arsenite	86-101	catalase	Homo sapiens	0-3
17009048-0	2007	Sodium arsenite-induced inhibition of cell proliferation is related to inhibition of IL-2 mRNA expression in mouse activated T cells.	sodium arsenite	0-15	interleukin 2	Mus musculus	85-89
17135312-6	2006	Immunodepletion of the NE with antibody against OGG1 or MYH decreased the incision of DNA adducts induced by As2O3, NaAsO2, monomethylarsonic acid, and dimethylarsinic acid, while antibodies against XPA, XPB, XPD, XPF, or XPG, did not.	sodium arsenite	116-122	8-oxoguanine DNA glycosylase	Homo sapiens	48-52
17135312-6	2006	Immunodepletion of the NE with antibody against OGG1 or MYH decreased the incision of DNA adducts induced by As2O3, NaAsO2, monomethylarsonic acid, and dimethylarsinic acid, while antibodies against XPA, XPB, XPD, XPF, or XPG, did not.	sodium arsenite	116-122	mutY DNA glycosylase	Homo sapiens	56-59
16861019-5	2006	Hsp110 mRNA and/or protein was detected constitutively in A6 kidney epithelial cells and was inducible by heat shock, sodium arsenite, and cadmium chloride.	sodium arsenite	118-133	heat shock protein family H (Hsp110) member 1 S homeolog	Xenopus laevis	0-6
17096945-1	2006	OBJECTIVE: To evaluate the effects of sodium arsenite on the activity, the mRNA and the protein expression of CAT in human keratinocyte cell line (HaCaT).	sodium arsenite	38-53	catalase	Homo sapiens	110-113
17096945-4	2006	RESULTS: If the cells were treated with higher than 5.0 micromol/L sodium arsenite, the activity, mRNA and protein expression of CAT were decreased significantly and in a dosage dependent fashion (P < 0.05).	sodium arsenite	67-82	catalase	Homo sapiens	129-132
16919243-8	2006	Nevertheless, we find significantly less co-localization of FMRP and TIA-1 and FMRP and its homologs in the neurites of differentiated PC12 cells treated with sodium arsenite than in the soma or growth cones.	sodium arsenite	159-174	fragile X messenger ribonucleoprotein 1	Rattus norvegicus	60-64
17096945-5	2006	CONCLUSION: CAT is inhibited by sodium arsenite in the transcription, translation and activity levels.	sodium arsenite	32-47	catalase	Homo sapiens	12-15
16919243-8	2006	Nevertheless, we find significantly less co-localization of FMRP and TIA-1 and FMRP and its homologs in the neurites of differentiated PC12 cells treated with sodium arsenite than in the soma or growth cones.	sodium arsenite	159-174	TIA1 cytotoxic granule-associated RNA binding protein	Rattus norvegicus	69-74
16713074-4	2006	Treatments of Huh7-DRE-Luc and Huh7 with NaAsO2 attenuated the 2,3,7,8-TCDD-induced DRE-CALUX and cytochrome P450 1A1 (CYP1A1) activations, respectively, in a dose-dependent manner.	sodium arsenite	41-47	MIR7-3 host gene	Homo sapiens	31-35
16919243-8	2006	Nevertheless, we find significantly less co-localization of FMRP and TIA-1 and FMRP and its homologs in the neurites of differentiated PC12 cells treated with sodium arsenite than in the soma or growth cones.	sodium arsenite	159-174	fragile X messenger ribonucleoprotein 1	Rattus norvegicus	79-83
16713074-4	2006	Treatments of Huh7-DRE-Luc and Huh7 with NaAsO2 attenuated the 2,3,7,8-TCDD-induced DRE-CALUX and cytochrome P450 1A1 (CYP1A1) activations, respectively, in a dose-dependent manner.	sodium arsenite	41-47	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	98-117
16713074-4	2006	Treatments of Huh7-DRE-Luc and Huh7 with NaAsO2 attenuated the 2,3,7,8-TCDD-induced DRE-CALUX and cytochrome P450 1A1 (CYP1A1) activations, respectively, in a dose-dependent manner.	sodium arsenite	41-47	MIR7-3 host gene	Homo sapiens	14-18
16713074-4	2006	Treatments of Huh7-DRE-Luc and Huh7 with NaAsO2 attenuated the 2,3,7,8-TCDD-induced DRE-CALUX and cytochrome P450 1A1 (CYP1A1) activations, respectively, in a dose-dependent manner.	sodium arsenite	41-47	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	119-125
16413591-5	2006	Insulin secretion and mRNA expression were evaluated in the presence of 1 and 5 microM sodium arsenite.	sodium arsenite	87-102	insulin	Homo sapiens	0-7
16966277-5	2006	HL-60 and K562 were treated with arsenic trioxide (As2O3) and sodium arsenite (NaAsO2) at concentrations between 0 - 10 microM for up to 48 h. The induction of apoptosis was accompanied by down-regulation of hTERT and wt1 mRNA and protein expression but up-regulation of par-4.	sodium arsenite	62-77	telomerase reverse transcriptase	Homo sapiens	208-213
16966277-5	2006	HL-60 and K562 were treated with arsenic trioxide (As2O3) and sodium arsenite (NaAsO2) at concentrations between 0 - 10 microM for up to 48 h. The induction of apoptosis was accompanied by down-regulation of hTERT and wt1 mRNA and protein expression but up-regulation of par-4.	sodium arsenite	62-77	WT1 transcription factor	Homo sapiens	218-221
16966277-5	2006	HL-60 and K562 were treated with arsenic trioxide (As2O3) and sodium arsenite (NaAsO2) at concentrations between 0 - 10 microM for up to 48 h. The induction of apoptosis was accompanied by down-regulation of hTERT and wt1 mRNA and protein expression but up-regulation of par-4.	sodium arsenite	62-77	Prader Willi/Angelman region RNA 4	Homo sapiens	271-276
16966277-5	2006	HL-60 and K562 were treated with arsenic trioxide (As2O3) and sodium arsenite (NaAsO2) at concentrations between 0 - 10 microM for up to 48 h. The induction of apoptosis was accompanied by down-regulation of hTERT and wt1 mRNA and protein expression but up-regulation of par-4.	sodium arsenite	79-85	telomerase reverse transcriptase	Homo sapiens	208-213
16966277-5	2006	HL-60 and K562 were treated with arsenic trioxide (As2O3) and sodium arsenite (NaAsO2) at concentrations between 0 - 10 microM for up to 48 h. The induction of apoptosis was accompanied by down-regulation of hTERT and wt1 mRNA and protein expression but up-regulation of par-4.	sodium arsenite	79-85	WT1 transcription factor	Homo sapiens	218-221
16966277-5	2006	HL-60 and K562 were treated with arsenic trioxide (As2O3) and sodium arsenite (NaAsO2) at concentrations between 0 - 10 microM for up to 48 h. The induction of apoptosis was accompanied by down-regulation of hTERT and wt1 mRNA and protein expression but up-regulation of par-4.	sodium arsenite	79-85	Prader Willi/Angelman region RNA 4	Homo sapiens	271-276
16818494-6	2006	Here we report evidence that sodium arsenite-induced apoptosis in PC12 cells may be due to direct phosphorylation of Bim(EL) at Ser-65 by p38.	sodium arsenite	29-44	mitogen activated protein kinase 14	Rattus norvegicus	138-141
16818494-8	2006	Furthermore, sodium arsenite induced Bim(EL) phosphorylation at Ser-65, which was blocked by p38 inhibition.	sodium arsenite	13-28	mitogen activated protein kinase 14	Rattus norvegicus	93-96
16883109-9	2006	RESULTS: Higher expressions of Hsp-70 were observed in BECs, which were induced by sodium arsenite.	sodium arsenite	83-98	heat shock protein family A (Hsp70) member 4	Homo sapiens	31-37
16530877-8	2006	Sodium arsenite, a strong inducer of oxidative stress and HO-1, reduced Bach1 expression in wild type Huh-7 cells, and NAC partially abrogated this decrease.	sodium arsenite	0-15	heme oxygenase 1	Homo sapiens	58-62
16530877-8	2006	Sodium arsenite, a strong inducer of oxidative stress and HO-1, reduced Bach1 expression in wild type Huh-7 cells, and NAC partially abrogated this decrease.	sodium arsenite	0-15	BTB domain and CNC homolog 1	Homo sapiens	72-77
16497974-6	2006	Sodium arsenite was shown to down-regulate the expression of survivin at both the protein and RNA levels in a time- and dose-dependent manner, thus inhibiting cell growth, inducing apoptosis, and enhancing the caspase-3 activity in ATL cells.	sodium arsenite	0-15	caspase 3	Homo sapiens	210-219
16413591-7	2006	We also showed a significant decrease in insulin mRNA expression of cells exposed to 5 microM sodium arsenite during 72 h. Our data suggest that arsenic may contribute to the development of diabetes mellitus by impairing pancreatic beta-cell functions, particularly insulin synthesis and secretion.	sodium arsenite	94-109	insulin	Homo sapiens	41-48
16487513-0	2006	Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells.	sodium arsenite	40-55	Fas ligand	Homo sapiens	86-96
16497974-8	2006	Sodium arsenite suppressed the constitutive NF-kappaB activation by preventing the IkappaB-alpha degradation and the nuclear translocation of NF-kappaB.	sodium arsenite	0-15	nuclear factor kappa B subunit 1	Homo sapiens	44-53
16497974-8	2006	Sodium arsenite suppressed the constitutive NF-kappaB activation by preventing the IkappaB-alpha degradation and the nuclear translocation of NF-kappaB.	sodium arsenite	0-15	NFKB inhibitor alpha	Homo sapiens	83-96
16497974-8	2006	Sodium arsenite suppressed the constitutive NF-kappaB activation by preventing the IkappaB-alpha degradation and the nuclear translocation of NF-kappaB.	sodium arsenite	0-15	nuclear factor kappa B subunit 1	Homo sapiens	142-151
16497974-10	2006	Sodium arsenite was shown to down-regulate the expression of survivin through the NF-kappaB pathway, thus inhibiting cell growth and promoting apoptosis of ATL cells.	sodium arsenite	0-15	nuclear factor kappa B subunit 1	Homo sapiens	82-91
16386761-3	2006	MGST1 activity was increased by ONOO(-) in the presence of high amounts of reducing agents including glutathione (GSH) and the activities increased by ONOO(-) or ONOO(-) plus GSH treatment were decreased by 30-40% by further incubation with dithiothreitol (DTT, reducing disulfide) or by sodium arsenite (reducing sulfenic acid).	sodium arsenite	288-303	microsomal glutathione S-transferase 1	Rattus norvegicus	0-5
16487513-3	2006	We report here the use of a combination of sodium arsenite, an inhibitor of NF-kappaB activation, and NS398, a cyclooxygenase-2 (COX-2) inhibitor, for restoration of the surface FasL expression.	sodium arsenite	43-58	Fas ligand	Homo sapiens	178-182
16338954-4	2006	In this study, the effects of sodium arsenite on the expression of securin in two tissue types of cell lines, the vascular endothelial and colorectal epithelial cells, were investigated.	sodium arsenite	30-45	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	67-74
16737587-16	2006	CONCLUSION: Sodium arsenite can induce expression of MRP2 and the up-regulation of MRP2 may play an important role in the bile secretion of arsenite and its metabolites.	sodium arsenite	12-27	ATP binding cassette subfamily C member 2	Rattus norvegicus	53-57
16737587-16	2006	CONCLUSION: Sodium arsenite can induce expression of MRP2 and the up-regulation of MRP2 may play an important role in the bile secretion of arsenite and its metabolites.	sodium arsenite	12-27	ATP binding cassette subfamily C member 2	Rattus norvegicus	83-87
16483355-11	2006	Administration of human chorionic gonadotrophin (hCG) along with sodium arsenite partially prevented the degeneration of germ cells and enhanced paired testicular weights, epididymal sperm count, plasma and intratesticular testosterone concentrations, activities of delta 5, 3beta-HSD, 17 beta-HSD and sorbitol dehydrogenase along with diminution in the activities of ACP, ALP and LDH.	sodium arsenite	65-80	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	286-297
16483355-11	2006	Administration of human chorionic gonadotrophin (hCG) along with sodium arsenite partially prevented the degeneration of germ cells and enhanced paired testicular weights, epididymal sperm count, plasma and intratesticular testosterone concentrations, activities of delta 5, 3beta-HSD, 17 beta-HSD and sorbitol dehydrogenase along with diminution in the activities of ACP, ALP and LDH.	sodium arsenite	65-80	sorbitol dehydrogenase	Homo sapiens	302-324
16483355-11	2006	Administration of human chorionic gonadotrophin (hCG) along with sodium arsenite partially prevented the degeneration of germ cells and enhanced paired testicular weights, epididymal sperm count, plasma and intratesticular testosterone concentrations, activities of delta 5, 3beta-HSD, 17 beta-HSD and sorbitol dehydrogenase along with diminution in the activities of ACP, ALP and LDH.	sodium arsenite	65-80	alkaline phosphatase, placental	Homo sapiens	373-376
16469751-9	2005	Sodium arsenite at low concentrations inhibited StAR protein but not mRNA expression and inhibited progesterone without disrupting delta psi(m).	sodium arsenite	0-15	steroidogenic acute regulatory protein	Mus musculus	48-52
16451733-3	2006	The mechanism of mammalian JNK activation by cadmium and sodium arsenite involves toxicant-induced oxidative stress.	sodium arsenite	57-72	mitogen-activated protein kinase 8	Homo sapiens	27-30
16275621-0	2005	Differential effect of sodium arsenite during the activation of human CD4+ and CD8+ T lymphocytes.	sodium arsenite	23-38	CD4 molecule	Homo sapiens	70-73
16275621-0	2005	Differential effect of sodium arsenite during the activation of human CD4+ and CD8+ T lymphocytes.	sodium arsenite	23-38	CD8a molecule	Homo sapiens	79-82
16275621-4	2005	In this paper we tested the effect of 1-5 muM NaAsO2 on the proliferation, viability, blast transformation, expression of the CD4 and CD8 molecules, and during the activation and proliferation of both CD4+ and CD8+ T lymphocytes.	sodium arsenite	46-52	CD4 molecule	Homo sapiens	126-129
16275621-4	2005	In this paper we tested the effect of 1-5 muM NaAsO2 on the proliferation, viability, blast transformation, expression of the CD4 and CD8 molecules, and during the activation and proliferation of both CD4+ and CD8+ T lymphocytes.	sodium arsenite	46-52	CD8a molecule	Homo sapiens	134-137
16275621-7	2005	Analysis of the expression of CD4 and CD8 molecules on these cells showed that concentrations > or = 2 microM NaAsO2 reduced the expression of the CD8 molecule and induced apoptosis/death in CD4+ cells.	sodium arsenite	113-119	CD4 molecule	Homo sapiens	30-33
16275621-7	2005	Analysis of the expression of CD4 and CD8 molecules on these cells showed that concentrations > or = 2 microM NaAsO2 reduced the expression of the CD8 molecule and induced apoptosis/death in CD4+ cells.	sodium arsenite	113-119	CD8a molecule	Homo sapiens	38-41
16275621-7	2005	Analysis of the expression of CD4 and CD8 molecules on these cells showed that concentrations > or = 2 microM NaAsO2 reduced the expression of the CD8 molecule and induced apoptosis/death in CD4+ cells.	sodium arsenite	113-119	CD8a molecule	Homo sapiens	150-153
16275621-7	2005	Analysis of the expression of CD4 and CD8 molecules on these cells showed that concentrations > or = 2 microM NaAsO2 reduced the expression of the CD8 molecule and induced apoptosis/death in CD4+ cells.	sodium arsenite	113-119	CD4 molecule	Homo sapiens	194-197
16275621-8	2005	Analysis of blast transformation by flow cytometry showed an accumulation of CD8+ resting cells in the presence of NaAsO2.	sodium arsenite	115-121	CD8a molecule	Homo sapiens	77-80
16275621-10	2005	However, in the case of CD8+ cells, we detected an accumulation of a CD25- CD69- population in the presence of increasing concentrations of NaAsO2.	sodium arsenite	140-146	CD8a molecule	Homo sapiens	24-27
16275621-10	2005	However, in the case of CD8+ cells, we detected an accumulation of a CD25- CD69- population in the presence of increasing concentrations of NaAsO2.	sodium arsenite	140-146	interleukin 2 receptor subunit alpha	Homo sapiens	69-73
16275621-10	2005	However, in the case of CD8+ cells, we detected an accumulation of a CD25- CD69- population in the presence of increasing concentrations of NaAsO2.	sodium arsenite	140-146	CD69 molecule	Homo sapiens	75-79
16275621-11	2005	Altogether, our results show that NaAsO2 alters the expression kinetics of the early activation molecules CD25 and CD69 similarly in both subtypes.	sodium arsenite	34-40	interleukin 2 receptor subunit alpha	Homo sapiens	106-110
16275621-11	2005	Altogether, our results show that NaAsO2 alters the expression kinetics of the early activation molecules CD25 and CD69 similarly in both subtypes.	sodium arsenite	34-40	CD69 molecule	Homo sapiens	115-119
16125204-3	2005	The MGST1 activity increased by gallic acid was decreased by further incubation with sodium arsenite, a sulfenic acid reducing agent, but was not with dithiothreitol, a disulfide bond reducing agent.	sodium arsenite	85-100	microsomal glutathione S-transferase 1	Rattus norvegicus	4-9
16283521-0	2005	Sodium arsenite-induced inhibition of eukaryotic translation initiation factor 4E (eIF4E) results in cytotoxicity and cell death.	sodium arsenite	0-15	eukaryotic translation initiation factor 4E	Homo sapiens	38-81
16283521-0	2005	Sodium arsenite-induced inhibition of eukaryotic translation initiation factor 4E (eIF4E) results in cytotoxicity and cell death.	sodium arsenite	0-15	eukaryotic translation initiation factor 4E	Homo sapiens	83-88
16283521-11	2005	Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells.	sodium arsenite	84-90	eukaryotic translation initiation factor 4E	Homo sapiens	113-118
16283521-6	2005	All the NaAsO2-treated cells exhibited significant inhibition of eIF4E gene (protein).	sodium arsenite	8-14	eukaryotic translation initiation factor 4E	Homo sapiens	65-70
16283521-11	2005	Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells.	sodium arsenite	84-90	eukaryotic translation initiation factor 4E	Homo sapiens	223-228
16283521-7	2005	The potential involvement of eIF4E gene expression in the NaAsO2-induced cytotoxicity and cell death was investigated by silencing the cellular expression of the eIF4E gene by employing a small interfering RNA (SiRNA) specifically targeting the eIF4E gene"s expression.	sodium arsenite	58-64	eukaryotic translation initiation factor 4E	Homo sapiens	29-34
16283521-7	2005	The potential involvement of eIF4E gene expression in the NaAsO2-induced cytotoxicity and cell death was investigated by silencing the cellular expression of the eIF4E gene by employing a small interfering RNA (SiRNA) specifically targeting the eIF4E gene"s expression.	sodium arsenite	58-64	eukaryotic translation initiation factor 4E	Homo sapiens	162-167
16283521-7	2005	The potential involvement of eIF4E gene expression in the NaAsO2-induced cytotoxicity and cell death was investigated by silencing the cellular expression of the eIF4E gene by employing a small interfering RNA (SiRNA) specifically targeting the eIF4E gene"s expression.	sodium arsenite	58-64	eukaryotic translation initiation factor 4E	Homo sapiens	162-167
16283521-11	2005	Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells.	sodium arsenite	84-90	eukaryotic translation initiation factor 4E	Gallus gallus	223-228
16283521-8	2005	The SiRNA-mediated silencing of eIF4E gene expression also resulted in significant cytotoxicity and cell death suggesting that the toxicity noticed among the NaAsO2-treated cells was probably due to the chemically induced inhibition of eIF4E gene expression.	sodium arsenite	158-164	eukaryotic translation initiation factor 4E	Homo sapiens	32-37
16283521-11	2005	Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells.	sodium arsenite	165-171	eukaryotic translation initiation factor 4E	Homo sapiens	113-118
16283521-8	2005	The SiRNA-mediated silencing of eIF4E gene expression also resulted in significant cytotoxicity and cell death suggesting that the toxicity noticed among the NaAsO2-treated cells was probably due to the chemically induced inhibition of eIF4E gene expression.	sodium arsenite	158-164	eukaryotic translation initiation factor 4E	Homo sapiens	236-241
16283521-11	2005	Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells.	sodium arsenite	165-171	eukaryotic translation initiation factor 4E	Homo sapiens	223-228
16283521-9	2005	The potential involvement of inhibition of eIF4E gene expression in the NaAsO2-induced cytotoxicity and cell death was further investigated by employing transgenic cell lines overexpressing the eIF4E gene.	sodium arsenite	72-78	eukaryotic translation initiation factor 4E	Homo sapiens	43-48
16283521-11	2005	Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells.	sodium arsenite	165-171	eukaryotic translation initiation factor 4E	Gallus gallus	223-228
16283521-11	2005	Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells.	sodium arsenite	165-171	eukaryotic translation initiation factor 4E	Homo sapiens	113-118
16283521-9	2005	The potential involvement of inhibition of eIF4E gene expression in the NaAsO2-induced cytotoxicity and cell death was further investigated by employing transgenic cell lines overexpressing the eIF4E gene.	sodium arsenite	72-78	eukaryotic translation initiation factor 4E	Homo sapiens	194-199
16283521-11	2005	Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells.	sodium arsenite	165-171	eukaryotic translation initiation factor 4E	Homo sapiens	223-228
16283521-11	2005	Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells.	sodium arsenite	165-171	eukaryotic translation initiation factor 4E	Gallus gallus	223-228
16283521-13	2005	Immunoprecipitation of lysates obtained from the NaAsO2-treated cells and the subsequent western blot analysis of the immunoprecipitated protein(s) using the eIF4E antibody detected the presence of eIF4E protein in the immunoprecipitate suggesting possible ubiquitination of eIF4E protein in the NaAsO2-treated cells.	sodium arsenite	49-55	eukaryotic translation initiation factor 4E	Homo sapiens	158-163
16283521-13	2005	Immunoprecipitation of lysates obtained from the NaAsO2-treated cells and the subsequent western blot analysis of the immunoprecipitated protein(s) using the eIF4E antibody detected the presence of eIF4E protein in the immunoprecipitate suggesting possible ubiquitination of eIF4E protein in the NaAsO2-treated cells.	sodium arsenite	49-55	eukaryotic translation initiation factor 4E	Homo sapiens	198-203
16283521-13	2005	Immunoprecipitation of lysates obtained from the NaAsO2-treated cells and the subsequent western blot analysis of the immunoprecipitated protein(s) using the eIF4E antibody detected the presence of eIF4E protein in the immunoprecipitate suggesting possible ubiquitination of eIF4E protein in the NaAsO2-treated cells.	sodium arsenite	49-55	eukaryotic translation initiation factor 4E	Homo sapiens	198-203
16283521-13	2005	Immunoprecipitation of lysates obtained from the NaAsO2-treated cells and the subsequent western blot analysis of the immunoprecipitated protein(s) using the eIF4E antibody detected the presence of eIF4E protein in the immunoprecipitate suggesting possible ubiquitination of eIF4E protein in the NaAsO2-treated cells.	sodium arsenite	296-302	eukaryotic translation initiation factor 4E	Homo sapiens	198-203
16283521-13	2005	Immunoprecipitation of lysates obtained from the NaAsO2-treated cells and the subsequent western blot analysis of the immunoprecipitated protein(s) using the eIF4E antibody detected the presence of eIF4E protein in the immunoprecipitate suggesting possible ubiquitination of eIF4E protein in the NaAsO2-treated cells.	sodium arsenite	296-302	eukaryotic translation initiation factor 4E	Homo sapiens	198-203
16283521-10	2005	Overexpression of the eIF4E gene in the Chinese hamster ovary cell line was protective against the NaAsO2-induced cytotoxicity and cell death.	sodium arsenite	99-105	eukaryotic translation initiation factor 4E	Cricetulus griseus	22-27
16180985-4	2005	Up-regulation of HSP70 expression was demonstrated following treatment with menadione, CdCl2 and NaAsO2, but not with the other chemicals tested.	sodium arsenite	97-103	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	17-22
16283521-14	2005	Pre-exposure of the NaAsO2-treated cells to proteasome inhibitors blocked the inhibition of eIF4E gene expression as well as the resulting cytotoxicity and cell death.	sodium arsenite	20-26	eukaryotic translation initiation factor 4E	Homo sapiens	92-97
16283521-15	2005	Furthermore, exposure of cells to NaAsO2 resulted in a significant inhibition of expression of the cell cycle and growth regulating gene, cyclin D1.	sodium arsenite	34-40	cyclin D1	Homo sapiens	138-147
16283521-17	2005	Transfection of cells with SiRNA specifically targeting eIF4E gene expression resulted in a significant inhibition of cyclin D1 gene suggesting that the observed inhibition of cyclin D1 gene in the NaAsO2-treated cells is most likely mediated through inhibition of eIF4E gene.	sodium arsenite	198-204	eukaryotic translation initiation factor 4E	Homo sapiens	56-61
16283521-17	2005	Transfection of cells with SiRNA specifically targeting eIF4E gene expression resulted in a significant inhibition of cyclin D1 gene suggesting that the observed inhibition of cyclin D1 gene in the NaAsO2-treated cells is most likely mediated through inhibition of eIF4E gene.	sodium arsenite	198-204	cyclin D1	Homo sapiens	118-127
16283521-17	2005	Transfection of cells with SiRNA specifically targeting eIF4E gene expression resulted in a significant inhibition of cyclin D1 gene suggesting that the observed inhibition of cyclin D1 gene in the NaAsO2-treated cells is most likely mediated through inhibition of eIF4E gene.	sodium arsenite	198-204	cyclin D1	Homo sapiens	176-185
16283521-17	2005	Transfection of cells with SiRNA specifically targeting eIF4E gene expression resulted in a significant inhibition of cyclin D1 gene suggesting that the observed inhibition of cyclin D1 gene in the NaAsO2-treated cells is most likely mediated through inhibition of eIF4E gene.	sodium arsenite	198-204	eukaryotic translation initiation factor 4E	Homo sapiens	265-270
16283521-18	2005	Taken together, our results indicate that the exposure of cells to NaAsO2 resulted in cytotoxicity and cell death, at least in part, due to the inhibition of eIF4E gene expression leading to diminished cellular levels of critical genes such as cyclin D1.	sodium arsenite	67-73	eukaryotic translation initiation factor 4E	Homo sapiens	158-163
16283521-18	2005	Taken together, our results indicate that the exposure of cells to NaAsO2 resulted in cytotoxicity and cell death, at least in part, due to the inhibition of eIF4E gene expression leading to diminished cellular levels of critical genes such as cyclin D1.	sodium arsenite	67-73	cyclin D1	Homo sapiens	244-253
15689417-0	2005	Oxidative stress mediates sodium arsenite-induced expression of heme oxygenase-1, monocyte chemoattractant protein-1, and interleukin-6 in vascular smooth muscle cells.	sodium arsenite	26-41	heme oxygenase 1	Homo sapiens	64-80
15689417-0	2005	Oxidative stress mediates sodium arsenite-induced expression of heme oxygenase-1, monocyte chemoattractant protein-1, and interleukin-6 in vascular smooth muscle cells.	sodium arsenite	26-41	C-C motif chemokine ligand 2	Homo sapiens	82-116
15689417-0	2005	Oxidative stress mediates sodium arsenite-induced expression of heme oxygenase-1, monocyte chemoattractant protein-1, and interleukin-6 in vascular smooth muscle cells.	sodium arsenite	26-41	interleukin 6	Homo sapiens	122-135
15741166-4	2005	Presently, small interference (si) RNA constructs were used to investigate the role of human BVR in sodium arsenite (As)-mediated induction of HO-1 and in cytoprotection against apoptosis.	sodium arsenite	100-115	biliverdin reductase A	Homo sapiens	93-96
15741166-4	2005	Presently, small interference (si) RNA constructs were used to investigate the role of human BVR in sodium arsenite (As)-mediated induction of HO-1 and in cytoprotection against apoptosis.	sodium arsenite	100-115	heme oxygenase 1	Homo sapiens	143-147
16180985-5	2005	A shorter exposure time (6 hours) and/or the use of non-toxic concentrations reduced the level of HSP70 up-regulation with menadione, CdCl2 and NaAsO2, but did not uncover any up-regulation with the other chemicals.	sodium arsenite	144-150	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	98-103
15537746-9	2005	Sodium arsenite exposure resulted in reduced tyrosine phosphorylation of FAK, its substrate paxillin and the FAK auto- phosphorylation site, Tyr397.	sodium arsenite	0-15	paxillin	Rattus norvegicus	92-100
15537746-0	2005	Sodium arsenite exposure alters cell migration, focal adhesion localization and decreases tyrosine phosphorylation of focal adhesion kinase in H9C2 myoblasts.	sodium arsenite	0-15	protein tyrosine kinase 2	Rattus norvegicus	118-139
15537746-9	2005	Sodium arsenite exposure resulted in reduced tyrosine phosphorylation of FAK, its substrate paxillin and the FAK auto- phosphorylation site, Tyr397.	sodium arsenite	0-15	protein tyrosine kinase 2	Rattus norvegicus	73-76
15537746-9	2005	Sodium arsenite exposure resulted in reduced tyrosine phosphorylation of FAK, its substrate paxillin and the FAK auto- phosphorylation site, Tyr397.	sodium arsenite	0-15	protein tyrosine kinase 2	Rattus norvegicus	109-112
15327774-2	2004	The stress-inducible gene Hsp70 is activated by heat shock or by sodium arsenite.	sodium arsenite	65-80	heat shock protein family A (Hsp70) member 4	Homo sapiens	26-31
15611262-2	2005	In this study, we show that the activation of the cellular stress response, either by heat shock treatment or after exposure to sodium arsenite, leads to a transient inhibition of IkappaBalpha phosphorylation.	sodium arsenite	128-143	NFKB inhibitor alpha	Homo sapiens	180-192
15893480-2	2005	In this study, immunocytochemical analysis and laser scanning confocal microscopy revealed that the shsp family, hsp30, was localized primarily in the cytoplasm of Xenopus A6 kidney epithelial cells after heat shock or sodium arsenite treatment.	sodium arsenite	219-234	heat shock protein 30E L homeolog	Xenopus laevis	113-118
15893480-4	2005	In sodium arsenite-treated cells hsp30 was enriched towards the cytoplasmic periphery as well as showing some immunostaining in the nucleus.	sodium arsenite	3-18	heat shock protein 30E L homeolog	Xenopus laevis	33-38
15893480-5	2005	At higher heat shock temperatures (35 degrees C) or after 10 microM sodium arsenite treatment, the actin cytoskeleton displayed some disorganization that co-localized with areas of hsp30 enrichment.	sodium arsenite	68-83	heat shock protein 30E L homeolog	Xenopus laevis	181-186
16416669-0	2005	Chronic exposure to arsenic sensitizes CD3+ and CD56+ human cells to sodium arsenite-mediated apoptosis.	sodium arsenite	69-84	neural cell adhesion molecule 1	Homo sapiens	48-52
15519606-3	2004	Our results reveal a significant increase in the degree of atherosclerotic plaque stenosis within the innominate artery of ApoE-/-/LDLr-/- mice treated with 10 ppm sodium arsenite (133 microM) in drinking water for 18 weeks compared to controls.	sodium arsenite	164-179	apolipoprotein E	Mus musculus	123-127
15519606-3	2004	Our results reveal a significant increase in the degree of atherosclerotic plaque stenosis within the innominate artery of ApoE-/-/LDLr-/- mice treated with 10 ppm sodium arsenite (133 microM) in drinking water for 18 weeks compared to controls.	sodium arsenite	164-179	low density lipoprotein receptor	Mus musculus	131-135
15476864-6	2004	SA augmented CDDP-induced increment of p27 but suppressed the increased expression of cyclin B1 and cyclin D1 at 3 days after CDDP.	sodium arsenite	0-2	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	39-42
15476864-6	2004	SA augmented CDDP-induced increment of p27 but suppressed the increased expression of cyclin B1 and cyclin D1 at 3 days after CDDP.	sodium arsenite	0-2	cyclin B1	Rattus norvegicus	86-95
15476864-6	2004	SA augmented CDDP-induced increment of p27 but suppressed the increased expression of cyclin B1 and cyclin D1 at 3 days after CDDP.	sodium arsenite	0-2	cyclin D1	Rattus norvegicus	100-109
15476864-7	2004	SA-induced attenuation of nephrotoxicity was associated with enhanced expression of proliferating cell nuclear antigen (PCNA) and growth-arrest and DNA damage (GADD) 153 in damaged tubular cells.	sodium arsenite	0-2	proliferating cell nuclear antigen	Rattus norvegicus	84-118
15476864-7	2004	SA-induced attenuation of nephrotoxicity was associated with enhanced expression of proliferating cell nuclear antigen (PCNA) and growth-arrest and DNA damage (GADD) 153 in damaged tubular cells.	sodium arsenite	0-2	proliferating cell nuclear antigen	Rattus norvegicus	120-124
15476864-8	2004	Our findings indicated that (1) proteins related to cell cycle regulation and DNA repair are induced in CDDP nephrotoxicity, (2) the SA-induced attenuation of CDDP nephrotoxicity is associated with increased expression of p27 and decreased expression of cyclin B1 and cyclin D1, they all induce cell cycle arrest at G1/S and G2/M, and (3) enhanced expression of DNA repair-related proteins is also associated with attenuation of CDDP-nephrotoxicity.	sodium arsenite	133-135	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	222-225
15476864-8	2004	Our findings indicated that (1) proteins related to cell cycle regulation and DNA repair are induced in CDDP nephrotoxicity, (2) the SA-induced attenuation of CDDP nephrotoxicity is associated with increased expression of p27 and decreased expression of cyclin B1 and cyclin D1, they all induce cell cycle arrest at G1/S and G2/M, and (3) enhanced expression of DNA repair-related proteins is also associated with attenuation of CDDP-nephrotoxicity.	sodium arsenite	133-135	cyclin B1	Rattus norvegicus	254-263
15476864-8	2004	Our findings indicated that (1) proteins related to cell cycle regulation and DNA repair are induced in CDDP nephrotoxicity, (2) the SA-induced attenuation of CDDP nephrotoxicity is associated with increased expression of p27 and decreased expression of cyclin B1 and cyclin D1, they all induce cell cycle arrest at G1/S and G2/M, and (3) enhanced expression of DNA repair-related proteins is also associated with attenuation of CDDP-nephrotoxicity.	sodium arsenite	133-135	cyclin D1	Rattus norvegicus	268-277
15130612-8	2004	Early-passage cells showed dose-responsive caspase-3 activation following exposure to sodium arsenite, whereas caspase-3 activation of late-passage cells dropped to background levels at toxicant dosages above 50 ppb.	sodium arsenite	86-101	caspase 3	Mus musculus	43-52
15217730-3	2004	Data presented in this study shows decreased expression of alpha- and beta-tubulin in wild type L. donovani promastigotes on exposure to NaAsO2 from 0.0016 to 5.0 microM (IC50 in the wild type strain) in a dose-dependent manner.	sodium arsenite	137-143	alpha tubulin	Leishmania donovani	59-82
14962831-3	2004	We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H(2)O(2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H(2)O(2)-stimulated ERK phosphorylation.	sodium arsenite	162-177	mitogen-activated protein kinase 1	Homo sapiens	35-38
14962831-3	2004	We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H(2)O(2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H(2)O(2)-stimulated ERK phosphorylation.	sodium arsenite	162-177	mitogen-activated protein kinase 1	Homo sapiens	148-151
15085064-4	2004	This study assessed the effect of manidipine on normal subjects" monocyte gene and protein expression of OxSt-related proteins such as p22(phox), a NAD(P)H oxidase system subunit, critical in generating O2-, and heme oxygenase-1 (HO-1), induced by and protective from OxSt, and compared manidipine with the ACE inhibitor captopril and the calcium channel blocker nifedipine, in the presence and absence of sodium arsenite (NaAsO2) as an inducer of OxSt.Co-incubation of manidipine with NaAsO2 dose-dependently decreased p22(phox) mRNA production from basal: 0.87 +/- 0.1 d.u., 0.69 +/- 0.06 and 0.66 +/- 0.09 at 100, 300 and 500 nM respectively versus 0.99 +/- 0.2, P < 0.04, while HO-1 mRNA production was increased by the same concentrations of the drug: 0.87 +/- 0.1 d.u., 0.92 +/- 0.1, 0.98 +/- 0.1 respectively versus 0.63 +/- 0.07; P < 0.03.	sodium arsenite	406-421	calcineurin like EF-hand protein 1	Homo sapiens	135-138
15116095-4	2004	Pretreatment with sodium arsenite strongly inhibited IL-6-inducible STAT3 tyrosine phosphorylation in HepG2 cells and did not affect its serine phosphorylation.	sodium arsenite	18-33	signal transducer and activator of transcription 3	Homo sapiens	68-73
15116095-5	2004	As a result, sodium arsenite completely abolished STAT activity-dependent expression of suppressors of cytokine signaling (SOCS).	sodium arsenite	13-28	cytokine inducible SH2 containing protein	Homo sapiens	123-127
15056798-0	2004	Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes.	sodium arsenite	29-44	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-68
15056798-0	2004	Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes.	sodium arsenite	29-44	cyclin dependent kinase 20	Homo sapiens	94-97
15085064-4	2004	This study assessed the effect of manidipine on normal subjects" monocyte gene and protein expression of OxSt-related proteins such as p22(phox), a NAD(P)H oxidase system subunit, critical in generating O2-, and heme oxygenase-1 (HO-1), induced by and protective from OxSt, and compared manidipine with the ACE inhibitor captopril and the calcium channel blocker nifedipine, in the presence and absence of sodium arsenite (NaAsO2) as an inducer of OxSt.Co-incubation of manidipine with NaAsO2 dose-dependently decreased p22(phox) mRNA production from basal: 0.87 +/- 0.1 d.u., 0.69 +/- 0.06 and 0.66 +/- 0.09 at 100, 300 and 500 nM respectively versus 0.99 +/- 0.2, P < 0.04, while HO-1 mRNA production was increased by the same concentrations of the drug: 0.87 +/- 0.1 d.u., 0.92 +/- 0.1, 0.98 +/- 0.1 respectively versus 0.63 +/- 0.07; P < 0.03.	sodium arsenite	423-429	calcineurin like EF-hand protein 1	Homo sapiens	135-138
15085064-4	2004	This study assessed the effect of manidipine on normal subjects" monocyte gene and protein expression of OxSt-related proteins such as p22(phox), a NAD(P)H oxidase system subunit, critical in generating O2-, and heme oxygenase-1 (HO-1), induced by and protective from OxSt, and compared manidipine with the ACE inhibitor captopril and the calcium channel blocker nifedipine, in the presence and absence of sodium arsenite (NaAsO2) as an inducer of OxSt.Co-incubation of manidipine with NaAsO2 dose-dependently decreased p22(phox) mRNA production from basal: 0.87 +/- 0.1 d.u., 0.69 +/- 0.06 and 0.66 +/- 0.09 at 100, 300 and 500 nM respectively versus 0.99 +/- 0.2, P < 0.04, while HO-1 mRNA production was increased by the same concentrations of the drug: 0.87 +/- 0.1 d.u., 0.92 +/- 0.1, 0.98 +/- 0.1 respectively versus 0.63 +/- 0.07; P < 0.03.	sodium arsenite	486-492	calcineurin like EF-hand protein 1	Homo sapiens	135-138
14673132-8	2004	Dexamethasone inhibited HSF1 binding at the Hsp70 promoter in response to heat or chemical shock (sodium arsenite).	sodium arsenite	98-113	heat shock protein family A (Hsp70) member 4	Homo sapiens	44-49
14676650-12	2003	In in vitro studies, PMNLs from 10 healthy volunteers were incubated at 37 degrees C, 34 degrees C, or 26 degrees C for 1 hour with sodium arsenite (100 micromol/L), an HSP inducer.	sodium arsenite	132-147	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	169-172
14989901-6	2004	These results indicated that sodium arsenite increase p55 gene expression, and inhibited PL and HOXA10 gene expression.	sodium arsenite	29-44	H3 histone pseudogene 44	Homo sapiens	54-57
14989901-6	2004	These results indicated that sodium arsenite increase p55 gene expression, and inhibited PL and HOXA10 gene expression.	sodium arsenite	29-44	homeobox A10	Homo sapiens	96-102
12640124-3	2003	Here we investigated the ability of caveolin-1 to modulate the cellular response to sodium arsenite and thereby alter survival of the human cell lines 293 and HeLa.	sodium arsenite	84-99	caveolin 1	Homo sapiens	36-46
14567983-4	2003	Thus, the effect of inorganic arsenic (as sodium arsenite) on Nrf2 expression and localization was studied in HaCaT cells, an immortalized human keratinocyte cell line.	sodium arsenite	42-57	NFE2 like bZIP transcription factor 2	Homo sapiens	62-66
14523996-0	2003	Sodium arsenite downregulates transcriptional activity of AP-1 and CRE binding proteins in IL-1beta-treated Caco-2 cells by increasing the expression of the transcriptional repressor CREMalpha.	sodium arsenite	0-15	interleukin 1 beta	Homo sapiens	91-99
14523996-1	2003	In recent studies, sodium arsenite (SA) inhibited IL-6 production in cultured intestinal epithelial cells, at least in part by downregulating the activity of nuclear factor-kappaB (NF-kappaB).	sodium arsenite	19-34	interleukin 6	Homo sapiens	50-54
14523996-1	2003	In recent studies, sodium arsenite (SA) inhibited IL-6 production in cultured intestinal epithelial cells, at least in part by downregulating the activity of nuclear factor-kappaB (NF-kappaB).	sodium arsenite	36-38	interleukin 6	Homo sapiens	50-54
14523996-3	2003	We tested the effect of SA on the activity of CCAAT/enhancer binding protein (C/EBP), activating protein-1 (AP-1), and CRE binding proteins in IL-1beta-treated Caco-2 cells.	sodium arsenite	24-26	CCAAT enhancer binding protein alpha	Homo sapiens	46-76
14523996-3	2003	We tested the effect of SA on the activity of CCAAT/enhancer binding protein (C/EBP), activating protein-1 (AP-1), and CRE binding proteins in IL-1beta-treated Caco-2 cells.	sodium arsenite	24-26	CCAAT enhancer binding protein alpha	Homo sapiens	78-83
14523996-3	2003	We tested the effect of SA on the activity of CCAAT/enhancer binding protein (C/EBP), activating protein-1 (AP-1), and CRE binding proteins in IL-1beta-treated Caco-2 cells.	sodium arsenite	24-26	interleukin 1 beta	Homo sapiens	143-151
14523996-8	2003	The present results are consistent with the concept that SA inhibits IL-6 production in stimulated enterocytes by downregulating the transcriptional activity of several, but not all, IL-6-related transcription factors.	sodium arsenite	57-59	interleukin 6	Homo sapiens	69-73
14523996-8	2003	The present results are consistent with the concept that SA inhibits IL-6 production in stimulated enterocytes by downregulating the transcriptional activity of several, but not all, IL-6-related transcription factors.	sodium arsenite	57-59	interleukin 6	Homo sapiens	183-187
14606951-2	2003	Quercetin completely inhibited the synthesis and intracellular accumulation of 70-kD heat shock protein (HSP70) in response to hyperthermia or to treatment with sodium arsenite, whereas dihydroquercetin in the same or higher doses had no such effect.	sodium arsenite	161-176	heat shock protein family A (Hsp70) member 4	Homo sapiens	85-110
12749847-3	2003	Both heat stress and sodium arsenite treatment in A6 cells resulted in a rapid activation of p38alpha and MAPKAPK-2.	sodium arsenite	21-36	mitogen-activated protein kinase 14 S homeolog	Xenopus laevis	93-101
12749847-3	2003	Both heat stress and sodium arsenite treatment in A6 cells resulted in a rapid activation of p38alpha and MAPKAPK-2.	sodium arsenite	21-36	MAPK activated protein kinase 2 L homeolog	Xenopus laevis	106-115
12637567-1	2003	Heme oxygenase-1 (HO-1) gene expression is induced by various oxidative stress stimuli including sodium arsenite.	sodium arsenite	97-112	heme oxygenase 1	Rattus norvegicus	0-22
12637567-3	2003	The Jun N-terminal kinase (JNK) inhibitor SP600125 decreased sodium arsenite-mediated induction of HO-1 mRNA expression.	sodium arsenite	61-76	mitogen-activated protein kinase 8	Rattus norvegicus	4-25
12637567-3	2003	The Jun N-terminal kinase (JNK) inhibitor SP600125 decreased sodium arsenite-mediated induction of HO-1 mRNA expression.	sodium arsenite	61-76	mitogen-activated protein kinase 8	Rattus norvegicus	27-30
12637567-3	2003	The Jun N-terminal kinase (JNK) inhibitor SP600125 decreased sodium arsenite-mediated induction of HO-1 mRNA expression.	sodium arsenite	61-76	heme oxygenase 1	Rattus norvegicus	99-103
12842450-3	2003	This study investigated if SLH induces in vivo HSP72 expression and whether in vitro HSP72 induction by sodium arsenite (NaArs) alters intracellular signal transduction and cytokine production similar to SLH.	sodium arsenite	104-119	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	85-90
14594625-3	2003	Wild-type and ApoE-deficient mice were exposed to 20 or 100 microg/mL sodium arsenite in drinking water for 24 weeks.	sodium arsenite	70-85	apolipoprotein E	Mus musculus	14-18
12757736-0	2003	Sodium arsenite retards proliferation of PHA-activated T cells by delaying the production and secretion of IL-2.	sodium arsenite	0-15	interleukin 2	Homo sapiens	107-111
12757736-3	2003	We reported previously a reduction in the secretion of IL-2 in NaAsO(2)-treated PBMCs stimulated with PHA, an observation that might explain, in part, the reduction in proliferation.	sodium arsenite	63-71	interleukin 2	Homo sapiens	55-59
12690470-9	2003	We also investigated the effect of co-administration of chelerythrine chloride (Chel), which inhibits the induction of HSPs, with SA on the expression of HSP72 and nephrotoxicity.	sodium arsenite	130-132	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	154-159
12690470-10	2003	Pretreatment with UA or SA significantly induced renal HSP72 expression.	sodium arsenite	24-26	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	55-60
12690470-12	2003	Co-administration of Chel with SA abolished the SA-induced increment of HSP72 and the beneficial effects of SA.	sodium arsenite	31-33	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	72-77
12690470-12	2003	Co-administration of Chel with SA abolished the SA-induced increment of HSP72 and the beneficial effects of SA.	sodium arsenite	48-50	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	72-77
12690470-12	2003	Co-administration of Chel with SA abolished the SA-induced increment of HSP72 and the beneficial effects of SA.	sodium arsenite	48-50	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	72-77
12640124-4	2003	Cells stably transfected with caveolin-1 were found to be much more sensitive to the toxic effects of sodium arsenite than either untransfected parental cells or parental cells transfected with an empty vector.	sodium arsenite	102-117	caveolin 1	Homo sapiens	30-40
12641444-7	2003	Of this group, arsenic trioxide was the strongest inducer of cellular p53, while dimethylarsinic acid, iododimethylarsine, and sodium arsenite also caused p53 induction in a dose- and time-dependent manner.	sodium arsenite	127-142	tumor protein p53	Homo sapiens	155-158
12388181-5	2003	IAP-I was also induced by sodium arsenite, which generates reactive oxygen species and is an inducer of members of the HSP family.	sodium arsenite	26-41	alkaline phosphatase, intestinal	Rattus norvegicus	0-5
12614848-2	2003	Here, we found that sodium arsenite (NaAsO(2)) also triggers the signal for activation of Akt and downstream glycogen synthase 3beta (GSK3beta).	sodium arsenite	20-35	AKT serine/threonine kinase 1	Homo sapiens	90-93
12614848-2	2003	Here, we found that sodium arsenite (NaAsO(2)) also triggers the signal for activation of Akt and downstream glycogen synthase 3beta (GSK3beta).	sodium arsenite	20-35	glycogen synthase kinase 3 beta	Homo sapiens	134-142
12482858-0	2003	Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite.	sodium arsenite	138-153	mitogen-activated protein kinase 14	Homo sapiens	23-26
12482858-0	2003	Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite.	sodium arsenite	138-153	vascular endothelial growth factor A	Homo sapiens	89-123
12482858-1	2003	Recently we have demonstrated that sodium arsenite induces the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) protein and vascular endothelial growth factor (VEGF) in OVCAR-3 human ovarian cancer cells.	sodium arsenite	35-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	77-108
12482858-1	2003	Recently we have demonstrated that sodium arsenite induces the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) protein and vascular endothelial growth factor (VEGF) in OVCAR-3 human ovarian cancer cells.	sodium arsenite	35-50	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-120
12482858-1	2003	Recently we have demonstrated that sodium arsenite induces the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) protein and vascular endothelial growth factor (VEGF) in OVCAR-3 human ovarian cancer cells.	sodium arsenite	35-50	vascular endothelial growth factor A	Homo sapiens	134-168
12482858-1	2003	Recently we have demonstrated that sodium arsenite induces the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) protein and vascular endothelial growth factor (VEGF) in OVCAR-3 human ovarian cancer cells.	sodium arsenite	35-50	vascular endothelial growth factor A	Homo sapiens	170-174
12482858-4	2003	By using kinase inhibitors in OVCAR-3 cells, both effects of sodium arsenite were found to be independent of phosphatidylinositol 3-kinase and p44/p42 MAPKS but were attenuated by inhibition of p38 MAPK.	sodium arsenite	61-76	interferon induced protein 44	Homo sapiens	143-146
12482858-4	2003	By using kinase inhibitors in OVCAR-3 cells, both effects of sodium arsenite were found to be independent of phosphatidylinositol 3-kinase and p44/p42 MAPKS but were attenuated by inhibition of p38 MAPK.	sodium arsenite	61-76	cyclin dependent kinase 20	Homo sapiens	147-150
12482858-4	2003	By using kinase inhibitors in OVCAR-3 cells, both effects of sodium arsenite were found to be independent of phosphatidylinositol 3-kinase and p44/p42 MAPKS but were attenuated by inhibition of p38 MAPK.	sodium arsenite	61-76	mitogen-activated protein kinase 14	Homo sapiens	194-197
12482858-9	2003	Altogether, these data suggest that not HIF-1, but rather p38, mediates induction of VEGF mRNA expression by sodium arsenite.	sodium arsenite	109-124	vascular endothelial growth factor A	Homo sapiens	85-89
12388181-5	2003	IAP-I was also induced by sodium arsenite, which generates reactive oxygen species and is an inducer of members of the HSP family.	sodium arsenite	26-41	selenoprotein K	Rattus norvegicus	119-122
12460802-0	2002	Expression of hsp 27, hsp 60, hsc 70, and hsp 70 stress response genes in cultured human urothelial cells (UROtsa) exposed to lethal and sublethal concentrations of sodium arsenite.	sodium arsenite	165-180	heat shock protein family B (small) member 1	Homo sapiens	14-20
13129816-5	2003	As(2)O(3)-induced apoptosis was associated with upregulation of p53 and caspase 3, whereas NaAsO(2)-induced apoptosis was associated with p53 upregulation.	sodium arsenite	91-99	tumor protein p53	Homo sapiens	138-141
12460802-0	2002	Expression of hsp 27, hsp 60, hsc 70, and hsp 70 stress response genes in cultured human urothelial cells (UROtsa) exposed to lethal and sublethal concentrations of sodium arsenite.	sodium arsenite	165-180	heat shock protein family A (Hsp70) member 4	Homo sapiens	42-48
12460802-8	2002	In contrast, hsp 70 expression was induced by NaAsO2 after both acute and extended exposure.	sodium arsenite	46-52	heat shock protein family A (Hsp70) member 4	Homo sapiens	13-19
12460802-9	2002	The degree and duration of the induction of the hsp 70 protein in the extended time course of exposure to NaAsO2 correlated directly with UROtsa cell cytotoxicity.	sodium arsenite	106-112	heat shock protein family A (Hsp70) member 4	Homo sapiens	48-54
12241537-2	2002	We tested the hypothesis that sodium arsenite inhibits IL-6 production in stimulated enterocytes and that this effect of arsenite is caused by down-regulation of NF-kappaB activity.	sodium arsenite	30-45	interleukin 6	Homo sapiens	55-59
12241537-7	2002	These effects of IL-1beta were inhibited by treatment of the cells with sodium arsenite in a dose- and time-dependent fashion.	sodium arsenite	72-87	interleukin 1 beta	Homo sapiens	17-25
12241537-8	2002	When cells were transfected with a plasmid expressing the p65 subunit of NF-kappaB, the inhibitory effect of sodium arsenite on NF-kappaB activity and IL-6 production was blunted.	sodium arsenite	109-124	RELA proto-oncogene, NF-kB subunit	Homo sapiens	58-82
12241537-8	2002	When cells were transfected with a plasmid expressing the p65 subunit of NF-kappaB, the inhibitory effect of sodium arsenite on NF-kappaB activity and IL-6 production was blunted.	sodium arsenite	109-124	nuclear factor kappa B subunit 1	Homo sapiens	73-82
12241537-8	2002	When cells were transfected with a plasmid expressing the p65 subunit of NF-kappaB, the inhibitory effect of sodium arsenite on NF-kappaB activity and IL-6 production was blunted.	sodium arsenite	109-124	interleukin 6	Homo sapiens	151-155
12241537-9	2002	These results suggest that sodium arsenite inhibits IL-6 production in enterocytes subjected to an inflammatory stimulus, and that this effect, at least in part, reflects down-regulated NF-kappaB activity.	sodium arsenite	27-42	interleukin 6	Homo sapiens	52-56
12241537-9	2002	These results suggest that sodium arsenite inhibits IL-6 production in enterocytes subjected to an inflammatory stimulus, and that this effect, at least in part, reflects down-regulated NF-kappaB activity.	sodium arsenite	27-42	nuclear factor kappa B subunit 1	Homo sapiens	186-195
12482204-6	2002	Heat shock or sodium arsenite induced phosphorylation of both chimeric Hsp27 and Hsp27, which resulted in the disaggregation of Hsp27 multimers in both cell types and disaggregation of 20% of the chimeric multimers in L929 cells.	sodium arsenite	14-29	heat shock protein 1	Mus musculus	71-76
12208374-3	2002	In the present study, we found that sodium arsenite induced downregulation of mRNA, protein expression, and enzyme activity of PHGPx in time- and dose-dependent manners.	sodium arsenite	36-51	glutathione peroxidase 4	Homo sapiens	127-132
12208374-5	2002	With the aid of agarose gel electrophoresis, and propidium iodide and annexin-V staining, we found that treatment of 30 microM sodium arsenite for 24 h induced apoptosis in human epidermoid carcinoma A431 cells and EA.hy926 cells.	sodium arsenite	127-142	annexin A5	Homo sapiens	70-79
12076508-1	2002	Both acute (24 h) and chronic (10-20 week) exposure of human fibroblast cells to low dose sodium arsenite (As(III)) significantly affects activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) DNA binding activity.	sodium arsenite	90-105	nuclear factor kappa B subunit 1	Homo sapiens	170-192
12076508-1	2002	Both acute (24 h) and chronic (10-20 week) exposure of human fibroblast cells to low dose sodium arsenite (As(III)) significantly affects activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) DNA binding activity.	sodium arsenite	90-105	nuclear factor kappa B subunit 1	Homo sapiens	194-204
12426128-0	2002	Sodium arsenite-induced stress-related gene expression in normal human epidermal, HaCaT, and HEL30 keratinocytes.	sodium arsenite	0-15	crystallin lambda 1	Homo sapiens	93-98
12119132-0	2002	Expression of hsp 90 in the human kidney and in proximal tubule cells exposed to heat, sodium arsenite and cadmium chloride.	sodium arsenite	87-102	heat shock protein 90 alpha family class A member 1	Homo sapiens	14-20
12076508-1	2002	Both acute (24 h) and chronic (10-20 week) exposure of human fibroblast cells to low dose sodium arsenite (As(III)) significantly affects activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) DNA binding activity.	sodium arsenite	90-105	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	160-164
12482204-6	2002	Heat shock or sodium arsenite induced phosphorylation of both chimeric Hsp27 and Hsp27, which resulted in the disaggregation of Hsp27 multimers in both cell types and disaggregation of 20% of the chimeric multimers in L929 cells.	sodium arsenite	14-29	heat shock protein 1	Mus musculus	81-86
12482204-6	2002	Heat shock or sodium arsenite induced phosphorylation of both chimeric Hsp27 and Hsp27, which resulted in the disaggregation of Hsp27 multimers in both cell types and disaggregation of 20% of the chimeric multimers in L929 cells.	sodium arsenite	14-29	heat shock protein 1	Mus musculus	81-86
12141822-0	2002	Induction of HSP72 by sodium arsenite fails to protect against cholecystokinin-octapeptide-induced acute pancreatitis in rats.	sodium arsenite	22-37	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	13-18
12141822-6	2002	HWI and the injection of sodium arsenite significantly elevated the expression of HSP72 in the pancreas and lungs, whereas they did not influence the levels of HSP60.	sodium arsenite	25-40	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	82-87
12141822-8	2002	In contrast, the nonthermal preinduction of HSP72 by sodium arsenite did not result in any beneficial effects on the measured parameters of the disease.	sodium arsenite	53-68	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	44-49
12016150-0	2002	Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice.	sodium arsenite	0-15	Harvey rat sarcoma virus oncogene	Mus musculus	76-82
12075113-5	2002	These studies revealed a differential requirement for the c-Jun N-terminal kinase (JNK) pathway for apoptosis induction by sodium arsenite in the resistant EW36 versus sensitive ST486 cell lines.	sodium arsenite	123-138	mitogen-activated protein kinase 8	Homo sapiens	58-81
12075113-5	2002	These studies revealed a differential requirement for the c-Jun N-terminal kinase (JNK) pathway for apoptosis induction by sodium arsenite in the resistant EW36 versus sensitive ST486 cell lines.	sodium arsenite	123-138	mitogen-activated protein kinase 8	Homo sapiens	83-86
12085988-7	2002	L-azetidine-2-carboxylic acid, sodium arsenite, CdCl2 and ZnCI2 caused induction of both isoforms of the hsp70 genes, even though their expression levels were variable.	sodium arsenite	31-46	heat shock protein 1B	Mus musculus	105-110
12095131-9	2002	In additional experiments, treatment of mice with sodium arsenite after induction of endotoxemia blunted the increase in NF-kappaB activity, indicating a therapeutic potential of sodium arsenite, in addition to its preventive effect.	sodium arsenite	50-65	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	121-130
12095131-9	2002	In additional experiments, treatment of mice with sodium arsenite after induction of endotoxemia blunted the increase in NF-kappaB activity, indicating a therapeutic potential of sodium arsenite, in addition to its preventive effect.	sodium arsenite	179-194	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	121-130
12016150-8	2002	Sodium arsenite increased genomic hypomethylation in a dose dependent manner and methyl-deficiency and sodium arsenite reduced the frequency of methylation at several cytosine sites within the promoter region of the oncogenic gene, Ha-ras.	sodium arsenite	0-15	Harvey rat sarcoma virus oncogene	Mus musculus	232-238
12016150-8	2002	Sodium arsenite increased genomic hypomethylation in a dose dependent manner and methyl-deficiency and sodium arsenite reduced the frequency of methylation at several cytosine sites within the promoter region of the oncogenic gene, Ha-ras.	sodium arsenite	103-118	Harvey rat sarcoma virus oncogene	Mus musculus	232-238
12054599-0	2002	Restoration of p53 tumor suppressor pathway in human cervical carcinoma cells by sodium arsenite.	sodium arsenite	81-96	tumor protein p53	Homo sapiens	15-18
12054599-5	2002	Two p53-responsive genes, p21(waf1/cip1) and mdm2, were induced after SA treatment.	sodium arsenite	70-72	tumor protein p53	Homo sapiens	4-7
12054599-5	2002	Two p53-responsive genes, p21(waf1/cip1) and mdm2, were induced after SA treatment.	sodium arsenite	70-72	cyclin dependent kinase inhibitor 1A	Homo sapiens	26-39
12054599-6	2002	Furthermore, SA also reduced the expressions of Cdc25A and cyclin B, blocked cell cycle progression at G2/M phase, and induced apoptosis in SiHa cells.	sodium arsenite	13-15	cell division cycle 25A	Homo sapiens	48-54
12054599-7	2002	SA-induced apoptosis was greatly reduced by expression of a dominant-negative mutated p53.	sodium arsenite	0-2	tumor protein p53	Homo sapiens	86-89
12054599-8	2002	In this study, we have first demonstrated that SA did repress E6 and E7 oncogenes, restore the p53 tumor suppressor pathway and induce apoptosis in SiHa cells.	sodium arsenite	47-49	tumor protein p53	Homo sapiens	95-98
11893605-1	2002	In previous studies, the heat shock response, induced by hyperthermia or sodium arsenite, increased interleukin (IL)-6 production in intestinal mucosa and cultured human enterocytes.	sodium arsenite	73-88	interleukin 6	Homo sapiens	100-118
11888201-8	2002	In contrast, sodium arsenite, a prototypical stress-type inducer of HO-1, led to down-regulation of the reporter gene down stream of MPRE.	sodium arsenite	13-28	heme oxygenase 1	Gallus gallus	68-72
11832385-8	2002	Plasma levels of the anti-inflammatory cytokine interleukin (IL)-10 were increased in septic mice pretreated with sodium arsenite, and the protective effect of sodium arsenite on intestinal permeability in septic mice was reversed by treatment with anti-IL-10 antibody.	sodium arsenite	114-129	interleukin 10	Mus musculus	48-67
11855834-2	2002	We have previously shown that mrp1(-/-) cells are hypersensitive to sodium arsenite, sodium arsenate, and antimony potassium tartrate.	sodium arsenite	68-83	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	30-34
11855834-3	2002	We now report that the retroviral vector-mediated overexpression of MRP1 and of the two subunits of gamma-GCS (heavy and light) resulted in higher intracellular glutathione levels and in a greater level of resistance to sodium arsenite and antimony potassium tartrate, compared to the overexpression of MRP1 and gamma-GCS heavy alone.	sodium arsenite	220-235	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	68-72
11914917-4	2002	In the mouse myocardial microvascular cell line, MyEnd, alphaB-crystallin as well as the heat shock proteins HSP 70i and HSP 25 display a low constitutive expression but can be significantly upregulated by sodium arsenite stress.	sodium arsenite	206-221	crystallin, alpha B	Mus musculus	56-73
11914917-4	2002	In the mouse myocardial microvascular cell line, MyEnd, alphaB-crystallin as well as the heat shock proteins HSP 70i and HSP 25 display a low constitutive expression but can be significantly upregulated by sodium arsenite stress.	sodium arsenite	206-221	heat shock protein 1	Mus musculus	121-127
12509260-4	2002	Our results showed that Mre11 went through cell cycle-dependent phosphorylation upon sodium arsenite treatment and this post-translational modification required NBS1 but not ATM.	sodium arsenite	85-100	MRE11 homolog, double strand break repair nuclease	Homo sapiens	24-29
12509260-4	2002	Our results showed that Mre11 went through cell cycle-dependent phosphorylation upon sodium arsenite treatment and this post-translational modification required NBS1 but not ATM.	sodium arsenite	85-100	nibrin	Homo sapiens	161-165
11832385-8	2002	Plasma levels of the anti-inflammatory cytokine interleukin (IL)-10 were increased in septic mice pretreated with sodium arsenite, and the protective effect of sodium arsenite on intestinal permeability in septic mice was reversed by treatment with anti-IL-10 antibody.	sodium arsenite	114-129	interleukin 10	Mus musculus	254-259
11832385-8	2002	Plasma levels of the anti-inflammatory cytokine interleukin (IL)-10 were increased in septic mice pretreated with sodium arsenite, and the protective effect of sodium arsenite on intestinal permeability in septic mice was reversed by treatment with anti-IL-10 antibody.	sodium arsenite	160-175	interleukin 10	Mus musculus	48-67
11832385-8	2002	Plasma levels of the anti-inflammatory cytokine interleukin (IL)-10 were increased in septic mice pretreated with sodium arsenite, and the protective effect of sodium arsenite on intestinal permeability in septic mice was reversed by treatment with anti-IL-10 antibody.	sodium arsenite	160-175	interleukin 10	Mus musculus	254-259
11706373-1	2002	The development toxicity of lead nitrate (25 mg/kg, SC), methylmercury chloride (12.5 mg/kg, PO), and sodium arsenite (6 mg/kg, SC) was assessed in CD1 mice following administration on gestation day 10 of these chemicals separately or in their binary and ternary combinations.	sodium arsenite	102-117	CD1 antigen complex	Mus musculus	148-151
11862762-3	2002	Chemical stress by sodium arsenite (arsenite) induces HSP27 coupled to the metabolic activity of the arachidonic acid cascade, and the HSP27 induction by arsenite is negatively regulated by activation of protein kinase C (PKC).	sodium arsenite	19-34	heat shock protein family B (small) member 1	Homo sapiens	54-59
11750083-10	2002	The mdr1a/1b(-/-) mice accumulated more arsenic in the liver (15.3 vs. 5.2 microg/g), kidney (7.23 vs. 3.22 microg/g), small intestine (3.98 vs. 1.57 microg/g) and brain (0.45 vs. 0.17 microg/g), as compared with wild-type mice 24 h after sodium arsenite (14 mg/kg, s.c.) administration.	sodium arsenite	239-254	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	4-9
11979425-0	2002	Acute sodium arsenite administration induces pulmonary CYP1A1 mRNA, protein and activity in the rat.	sodium arsenite	6-21	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	55-61
11892989-5	2002	On the other hand, exposure to sodium arsenite or azetidine induced an increased accumulation of hsc70 mRNA, but did not lead to a concomitant increase in the level of U14 snoRNA.	sodium arsenite	31-46	heat shock cognate 71 kDa protein	Cricetulus griseus	97-102
11979426-0	2002	Acute sodium arsenite treatment induces Cyp2a5 but not Cyp1a1 in the C57Bl/6 mouse in a tissue (kidney) selective manner.	sodium arsenite	6-21	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	40-46
11835394-7	2002	Results from additional experiments showed that the protective effect of sodium arsenite on IkappaBalpha was not influenced by the oxygen radical scavenger catalase or by inhibitors of the MAP-kinase signaling pathway.	sodium arsenite	73-88	NFKB inhibitor alpha	Homo sapiens	92-104
11807808-0	2002	Involvement of p38 mitogen-activated protein kinase in the cell growth inhibition by sodium arsenite.	sodium arsenite	85-100	mitogen-activated protein kinase 14	Mus musculus	15-51
11807808-3	2002	Here, we examined possible roles of p38MAPK in the sodium arsenite-induced cell growth inhibition in NIH3T3 cells.	sodium arsenite	51-66	mitogen-activated protein kinase 14	Mus musculus	36-43
11807808-4	2002	Sodium arsenite induced transient cell growth delay with marked activation of p38MAPK.	sodium arsenite	0-15	mitogen-activated protein kinase 14	Mus musculus	78-85
11835394-1	2002	Recent studies suggest that sodium arsenite downregulates NF-kappaB activity by inhibiting phosphorylation and subsequent degradation of IkappaBalpha.	sodium arsenite	28-43	nuclear factor kappa B subunit 1	Homo sapiens	58-67
11835394-8	2002	The present results suggest that sodium arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1beta-stimulated Caco-2 cells independent of the heat shock response.	sodium arsenite	33-48	NFKB inhibitor alpha	Homo sapiens	60-72
11835394-1	2002	Recent studies suggest that sodium arsenite downregulates NF-kappaB activity by inhibiting phosphorylation and subsequent degradation of IkappaBalpha.	sodium arsenite	28-43	NFKB inhibitor alpha	Homo sapiens	137-149
11835394-6	2002	Sodium arsenite blocked all of these responses to IL-1beta without inducing changes in heat shock factor activity or heat shock protein levels.	sodium arsenite	0-15	interleukin 1 beta	Homo sapiens	50-58
11807808-7	2002	pRB was hypophosphorylated by sodium arsenite.	sodium arsenite	30-45	RB transcriptional corepressor 1	Mus musculus	0-3
11807808-11	2002	These data demonstrate a possible link between the activation of p38MAPK and induction of p21(CIP1/WAF1), suggesting that the activation of p38MAPK is, at least in part, related to the cell growth inhibition by sodium arsenite.	sodium arsenite	211-226	mitogen-activated protein kinase 14	Mus musculus	65-72
11835394-8	2002	The present results suggest that sodium arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1beta-stimulated Caco-2 cells independent of the heat shock response.	sodium arsenite	33-48	nuclear factor kappa B subunit 1	Homo sapiens	86-95
11807808-11	2002	These data demonstrate a possible link between the activation of p38MAPK and induction of p21(CIP1/WAF1), suggesting that the activation of p38MAPK is, at least in part, related to the cell growth inhibition by sodium arsenite.	sodium arsenite	211-226	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	90-93
11807808-11	2002	These data demonstrate a possible link between the activation of p38MAPK and induction of p21(CIP1/WAF1), suggesting that the activation of p38MAPK is, at least in part, related to the cell growth inhibition by sodium arsenite.	sodium arsenite	211-226	mitogen-activated protein kinase 14	Mus musculus	140-147
11835394-8	2002	The present results suggest that sodium arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1beta-stimulated Caco-2 cells independent of the heat shock response.	sodium arsenite	33-48	interleukin 1 beta	Homo sapiens	110-118
11835394-9	2002	In addition, stabilization of IkappaBalpha by sodium arsenite does not require oxygen radical formation or activation of the MAP kinase signaling pathway.	sodium arsenite	46-61	NFKB inhibitor alpha	Homo sapiens	30-42
11825526-4	2001	(2) The expressions of p16 gene in the groups of sodium arsenite and sodium arsenate at the test were lower than that of the control group, especially in the groups of sodium arsenite.	sodium arsenite	49-64	cyclin dependent kinase inhibitor 2A	Homo sapiens	23-26
11740261-5	2001	Quercetin (30 microM), a suppressor of HSP, and sodium arsenite (100 microM), an inducer of HSP, were used to regulate the expression of HSP70 in PMNLs, and oxidative activity and apoptosis in these cells were measured.	sodium arsenite	48-63	heat shock protein family A (Hsp70) member 4	Homo sapiens	137-142
11740261-8	2001	In the in vitro studies, administration of sodium arsenite enhanced the expression of HSP70, significantly increased oxidative activity, and inhibited apoptosis.	sodium arsenite	43-58	heat shock protein family A (Hsp70) member 4	Homo sapiens	86-91
11825526-4	2001	(2) The expressions of p16 gene in the groups of sodium arsenite and sodium arsenate at the test were lower than that of the control group, especially in the groups of sodium arsenite.	sodium arsenite	168-183	cyclin dependent kinase inhibitor 2A	Homo sapiens	23-26
11574405-9	2001	Insulin and sodium arsenite, an activator of the stress-activated pathway, also stimulated PDX-1 movement from the nuclear periphery to the nucleoplasm.	sodium arsenite	12-27	pancreatic and duodenal homeobox 1	Homo sapiens	91-96
11746514-2	2001	In the present study, we examined the effects of midazolam, an intravenous anesthetic, on the HSP27 induction stimulated by vasopressin, heat, or sodium arsenite (arsenite) in A10 cells.	sodium arsenite	146-161	heat shock protein family B (small) member 1	Homo sapiens	94-99
11497330-2	2001	It was demonstrated that the HK-2 cells did not exhibit the classic heat-shock response when subjected to an acute physical (heat) or chemical stress (sodium arsenite or CdCl2).	sodium arsenite	151-166	hexokinase 2	Homo sapiens	29-33
11368792-13	2001	Furthermore, treatment of cells with sodium arsenite increased levels of haem oxygenase concomitant with a marked decrease of spectrally detectable CYP2D6 and a rise in levels of ferritin, which sequesters free iron released from the destruction of haem.	sodium arsenite	37-52	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	148-154
11368792-13	2001	Furthermore, treatment of cells with sodium arsenite increased levels of haem oxygenase concomitant with a marked decrease of spectrally detectable CYP2D6 and a rise in levels of ferritin, which sequesters free iron released from the destruction of haem.	sodium arsenite	37-52	ferritin, mitochondrial	Cricetulus griseus	179-187
11322385-2	2001	Our data show that chemical treatments including sodium arsenite and curcumin, induced significant synthesis of HSP70 and its mRNA.	sodium arsenite	49-64	heat shock protein family A (Hsp70) member 4	Homo sapiens	112-117
11322385-5	2001	Phosphorylation and activation of extracellular signal-regulated proteins (ERK1/2) were detected in sodium arsenite-treated COLO205 and HT29 cells, and the free radical scavenger N-acetyl-L-cysteine (NAC) was able to inhibit this ERK1/2 activation and HSP70 gene expression.	sodium arsenite	100-115	mitogen-activated protein kinase 3	Homo sapiens	75-81
11322385-5	2001	Phosphorylation and activation of extracellular signal-regulated proteins (ERK1/2) were detected in sodium arsenite-treated COLO205 and HT29 cells, and the free radical scavenger N-acetyl-L-cysteine (NAC) was able to inhibit this ERK1/2 activation and HSP70 gene expression.	sodium arsenite	100-115	X-linked Kx blood group	Homo sapiens	200-203
11322385-5	2001	Phosphorylation and activation of extracellular signal-regulated proteins (ERK1/2) were detected in sodium arsenite-treated COLO205 and HT29 cells, and the free radical scavenger N-acetyl-L-cysteine (NAC) was able to inhibit this ERK1/2 activation and HSP70 gene expression.	sodium arsenite	100-115	mitogen-activated protein kinase 3	Homo sapiens	230-236
11322385-5	2001	Phosphorylation and activation of extracellular signal-regulated proteins (ERK1/2) were detected in sodium arsenite-treated COLO205 and HT29 cells, and the free radical scavenger N-acetyl-L-cysteine (NAC) was able to inhibit this ERK1/2 activation and HSP70 gene expression.	sodium arsenite	100-115	heat shock protein family A (Hsp70) member 4	Homo sapiens	252-257
11322385-6	2001	MAPK blockade by the specific MEK1 inhibitor (PD98059) decreased the ability of sodium arsenite to increase HSP70 gene expression in a dose-dependent manner along with dephosphorylation of ERK1/2 proteins.	sodium arsenite	80-95	mitogen-activated protein kinase kinase 1	Homo sapiens	30-34
11322385-6	2001	MAPK blockade by the specific MEK1 inhibitor (PD98059) decreased the ability of sodium arsenite to increase HSP70 gene expression in a dose-dependent manner along with dephosphorylation of ERK1/2 proteins.	sodium arsenite	80-95	heat shock protein family A (Hsp70) member 4	Homo sapiens	108-113
11322385-6	2001	MAPK blockade by the specific MEK1 inhibitor (PD98059) decreased the ability of sodium arsenite to increase HSP70 gene expression in a dose-dependent manner along with dephosphorylation of ERK1/2 proteins.	sodium arsenite	80-95	mitogen-activated protein kinase 3	Homo sapiens	189-195
11322385-9	2001	These results indicated that the ERK signaling pathway can participate in HSP70 gene expression induced by the prooxidant sodium arsenite, but not by the antioxidant curcumin.	sodium arsenite	122-137	mitogen-activated protein kinase 3	Homo sapiens	33-36
11322385-9	2001	These results indicated that the ERK signaling pathway can participate in HSP70 gene expression induced by the prooxidant sodium arsenite, but not by the antioxidant curcumin.	sodium arsenite	122-137	heat shock protein family A (Hsp70) member 4	Homo sapiens	74-79
11446828-7	2001	Interestingly, sodium arsenite selectively activated p38 and JNK3, but not JNK1 or JNK2 in cerebellar neurons.	sodium arsenite	15-30	mitogen activated protein kinase 14	Rattus norvegicus	53-56
11446828-7	2001	Interestingly, sodium arsenite selectively activated p38 and JNK3, but not JNK1 or JNK2 in cerebellar neurons.	sodium arsenite	15-30	mitogen activated protein kinase 10	Rattus norvegicus	61-65
11408547-3	2001	Treatment of primary rat hepatocytes by sodium arsenite [As(III)], sodium arsenate and potassium antimony tartrate, but not cadmium chloride, was shown to markedly increase MRP2 mRNA and protein levels; As(III)-mediated induction was dose- and time-dependent and paralleled a strong increase in MRP2 amounts as assessed by Western blotting.	sodium arsenite	40-55	ATP binding cassette subfamily C member 2	Rattus norvegicus	173-177
11408547-3	2001	Treatment of primary rat hepatocytes by sodium arsenite [As(III)], sodium arsenate and potassium antimony tartrate, but not cadmium chloride, was shown to markedly increase MRP2 mRNA and protein levels; As(III)-mediated induction was dose- and time-dependent and paralleled a strong increase in MRP2 amounts as assessed by Western blotting.	sodium arsenite	40-55	ATP binding cassette subfamily C member 2	Rattus norvegicus	295-299
11319142-5	2001	Using a sensitive reverse transcriptase-PCR assay we have investigated the expression of gadd153 and beta-actin in blastocyst-stage bovine embryos treated with MMS or sodium arsenite.	sodium arsenite	167-182	beta actin	Bos taurus	101-111
11148216-3	2001	Recent studies suggest that an important component of cell death following diverse stress stimuli (e.g. interleukin-3 withdrawal, sodium arsenite treatment, and peroxide treatment) is the activation of the double-stranded RNA-activable protein kinase, PKR, resulting in the inhibition of protein synthesis (Ito, T., Jagus, R., and May, W. S. (1994) Proc.	sodium arsenite	130-145	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	252-255
11160250-4	2001	SA inhibited LPS-induced NF-kappaB activation by preventing loss of IkappaB-alpha and -beta.	sodium arsenite	0-2	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	68-91
11160250-5	2001	Furthermore, SA blocked phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2), but not phosphorylation of p38 and c-Jun N-terminal kinase.	sodium arsenite	13-15	mitogen-activated protein kinase 3	Mus musculus	43-84
11160250-5	2001	Furthermore, SA blocked phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2), but not phosphorylation of p38 and c-Jun N-terminal kinase.	sodium arsenite	13-15	mitogen-activated protein kinase 3	Mus musculus	86-92
11160250-6	2001	SA treatment resulted in the disappearance of Raf-1, suggesting that it might cause the inhibition of the Erk1/2 mitogen-activated protein (MAP) kinase pathway.	sodium arsenite	0-2	v-raf-leukemia viral oncogene 1	Mus musculus	46-51
11160250-6	2001	SA treatment resulted in the disappearance of Raf-1, suggesting that it might cause the inhibition of the Erk1/2 mitogen-activated protein (MAP) kinase pathway.	sodium arsenite	0-2	mitogen-activated protein kinase 3	Mus musculus	106-112
11160250-9	2001	Taken together, these results indicate that the inhibitory action of SA on NO production in LPS-stimulated macrophages might be due to abrogation of inducible NO synthase induction, and it might be closely related to inactivation of the NF-kappaB and Erk1/2 MAP kinase pathways through loss of Raf-1.	sodium arsenite	69-71	nitric oxide synthase 2, inducible	Mus musculus	149-170
11160250-9	2001	Taken together, these results indicate that the inhibitory action of SA on NO production in LPS-stimulated macrophages might be due to abrogation of inducible NO synthase induction, and it might be closely related to inactivation of the NF-kappaB and Erk1/2 MAP kinase pathways through loss of Raf-1.	sodium arsenite	69-71	mitogen-activated protein kinase 3	Mus musculus	251-257
11160250-9	2001	Taken together, these results indicate that the inhibitory action of SA on NO production in LPS-stimulated macrophages might be due to abrogation of inducible NO synthase induction, and it might be closely related to inactivation of the NF-kappaB and Erk1/2 MAP kinase pathways through loss of Raf-1.	sodium arsenite	69-71	v-raf-leukemia viral oncogene 1	Mus musculus	294-299
11423728-2	2001	This study was performed to evaluate the effect of heat-shock protein (HSP)70 induction with sodium arsenite (SA) on ischemia/reperfusion (I/R) or cyclosporin A (CsA)-induced injuries in rat kidney.	sodium arsenite	93-108	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	51-77
11423728-2	2001	This study was performed to evaluate the effect of heat-shock protein (HSP)70 induction with sodium arsenite (SA) on ischemia/reperfusion (I/R) or cyclosporin A (CsA)-induced injuries in rat kidney.	sodium arsenite	110-112	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	51-77
11423728-8	2001	Induction of HSP70 with SA improved both renal function and the histopathology score as compared to the group without HSP70 induction.	sodium arsenite	24-26	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	13-18
11423728-11	2001	In conclusion, SA pretreatment prevents subsequent I/R or CsA-induced injuries in the rat kidney, and this renoprotective effect appears to be mediated by induction of HSP70.	sodium arsenite	15-17	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	168-173
11042089-6	2000	These results indicate the induction of CYP1A4 and 1A5 is inhibited by sodium arsenite at the level of transcription, suggesting that the Ah receptor complex may be involved.	sodium arsenite	71-86	cytochrome P450 1A4	Gallus gallus	40-46
11198361-0	2001	Effect of sodium arsenite on iNOS expression and vascular hyporeactivity associated with cecal ligation and puncture in the rat.	sodium arsenite	10-25	nitric oxide synthase 2	Rattus norvegicus	29-33
11198361-6	2001	Pretreatment of the rats with SA resulted in reversal of CLP-induced vascular hyporeactivity in vivo and ex vivo, and inhibition of iNOS expression after 22 h. SA pretreatment improved 7-day survival after CLP from 18.2% to 70% (P < 0.005).	sodium arsenite	160-162	nitric oxide synthase 2	Rattus norvegicus	132-136
11099391-6	2000	Hyperthermia and sodium arsenite increased hsp72 levels in the intestinal mucosa.	sodium arsenite	17-32	heat shock protein 1A	Mus musculus	43-48
10952983-3	2000	A dominant-negative allele of Rac1 (Rac1N17) inhibits the hypoxia/reoxygenation and sodium arsenite-induced transcriptional activity of HSF-1 and the transcription of heat shock protein 70.	sodium arsenite	84-99	Rac family small GTPase 1	Homo sapiens	30-34
10952983-3	2000	A dominant-negative allele of Rac1 (Rac1N17) inhibits the hypoxia/reoxygenation and sodium arsenite-induced transcriptional activity of HSF-1 and the transcription of heat shock protein 70.	sodium arsenite	84-99	heat shock transcription factor 1	Homo sapiens	136-141
10986282-3	2000	Here, we report that the expression of mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1), transforming growth factor-beta-activated kinase (TAK1), and apoptosis signal-regulating kinase (ASK1) in HepG2 cells activated the ARE reporter gene, whereas the expression of their dominant-negative mutants impaired ARE activation by the chemicals sodium arsenite and mercury chloride.	sodium arsenite	391-406	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	238-242
11078701-8	2000	On the other hand, sodium arsenite, a known activator of the stress response pathway, induced HO-1 mRNA expression but lacked a promoting effect on TG production.	sodium arsenite	19-34	heme oxygenase 1	Homo sapiens	94-98
11035063-8	2000	beta cyclodextrin, which sequestrates cholesterol from the membrane rafts, inhibited NaAsO(2)-induced activation of protein tyrosine kinases and MAP family kinases, degradation of PARP, and production of superoxide.	sodium arsenite	85-93	poly (ADP-ribose) polymerase family, member 1	Mus musculus	180-184
11035063-10	2000	These results suggest that a membrane raft integrity-dependent cell surface event is a prerequisite for NaAsO(2)-induced protein tyrosine kinase/c-Jun amino-terminal kinase activation, superoxide production, and downstream caspase activation.	sodium arsenite	104-112	jun proto-oncogene	Mus musculus	145-150
10906077-6	2000	Treatments of isolated tubules with either sodium arsenite, known to induce HO-1, or hematin, an HO substrate, resulted in 4.4- and 1.8-fold, respectively, increases in cGMP levels.	sodium arsenite	43-58	heme oxygenase 1	Homo sapiens	76-80
10964950-3	2000	Here we investigated the role of JNK and p38 in cortical neuron apoptosis caused by sodium arsenite treatment.	sodium arsenite	84-99	mitogen-activated protein kinase 8	Homo sapiens	33-36
10964950-5	2000	Treatment of cortical neurons with sodium arsenite activated p38 and JNK3 but not JNK1 or JNK2.	sodium arsenite	35-50	mitogen-activated protein kinase 14	Homo sapiens	61-64
10964950-5	2000	Treatment of cortical neurons with sodium arsenite activated p38 and JNK3 but not JNK1 or JNK2.	sodium arsenite	35-50	mitogen-activated protein kinase 10	Homo sapiens	69-73
11035063-4	2000	We demonstrated that NaAsO(2)-induced caspase activation is dependent on curcumin-sensitive c-Jun amino-terminal kinase and barely dependent on SB203580-sensitive p38 kinase or PD98059-sensitive extracellular signal-regulated kinase.	sodium arsenite	21-29	jun proto-oncogene	Mus musculus	92-97
10802388-4	2000	Similar results were obtained when the cells were subjected to a classic chemical stress of exposure to 100 microM sodium arsenite for 4 h. Acute exposure of HPT cells to 53.4 microM CdCl(2) for 4 h also resulted in an increase in hsp 60 mRNA and protein following removal of the metal.	sodium arsenite	115-130	heat shock protein family D (Hsp60) member 1	Homo sapiens	231-237
10942197-1	2000	Previously, chick heme oxygenase-1 (cHO-1) gene was cloned by us and two regions important for induction by sodium arsenite were identified.	sodium arsenite	108-123	heme oxygenase 1	Gallus gallus	18-34
10942197-4	2000	DNA binding studies and site-directed mutagenesis studies indicated that both the AP-1 and MRE/cMyc elements are important for the sodium arsenite induction, while cobalt chloride induction involves only the AP-1 element.	sodium arsenite	131-146	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	95-99
10942197-6	2000	Site-directed mutagenesis studies showed that, to completely abolish sodium arsenite induction, both the AP-1 and MRE/cMyc elements must be mutated; mutation of either element alone resulted in only a partial effect.	sodium arsenite	69-84	v-myc avian myelocytomatosis viral oncogene homolog	Gallus gallus	118-122
10799907-4	2000	Both HS and sodium arsenite treatment increased HSP70 expression time dependently at mRNA and protein levels.	sodium arsenite	12-27	heat shock protein family A (Hsp70) member 4	Homo sapiens	48-53
10652248-2	2000	Previously, we showed that the cell death induced in day 9 mouse embryos by three teratogens, hyperthermia (HS), 4-hydroperoxycyclophosphamide (4-CP), and sodium arsenite (As), is apoptotic in nature involving the activation of caspase-3, cleavage of poly(ADP-ribose) polymerase (PARP), and DNA fragmentation.	sodium arsenite	155-170	caspase 3	Mus musculus	228-237
10792534-3	2000	In laboratory strains of Saccharomyces cerevisiae, the heat shock protein, Hsp104, plays a major role in the acquisition of tolerance to a variety of stresses such as heat, ethanol and sodium arsenite, and as such acts as an excellent stress indicator.	sodium arsenite	185-200	chaperone ATPase HSP104	Saccharomyces cerevisiae S288C	75-81
10841042-1	2000	In a previous study, we have demonstrated that sodium arsenite (arsenite) as chemical stress stimulates heat shock protein 27 (HSP27) induction and arachidonic acid release in osteoblast-like MC3T3-E1 cells, and that the response of HSP27 induction is coupled with metabolic activity of the arachidonic acid cascade.	sodium arsenite	47-62	heat shock protein 1	Mus musculus	104-125
10841042-1	2000	In a previous study, we have demonstrated that sodium arsenite (arsenite) as chemical stress stimulates heat shock protein 27 (HSP27) induction and arachidonic acid release in osteoblast-like MC3T3-E1 cells, and that the response of HSP27 induction is coupled with metabolic activity of the arachidonic acid cascade.	sodium arsenite	47-62	heat shock protein 1	Mus musculus	127-132
10841042-1	2000	In a previous study, we have demonstrated that sodium arsenite (arsenite) as chemical stress stimulates heat shock protein 27 (HSP27) induction and arachidonic acid release in osteoblast-like MC3T3-E1 cells, and that the response of HSP27 induction is coupled with metabolic activity of the arachidonic acid cascade.	sodium arsenite	47-62	heat shock protein 1	Mus musculus	233-238
10652248-2	2000	Previously, we showed that the cell death induced in day 9 mouse embryos by three teratogens, hyperthermia (HS), 4-hydroperoxycyclophosphamide (4-CP), and sodium arsenite (As), is apoptotic in nature involving the activation of caspase-3, cleavage of poly(ADP-ribose) polymerase (PARP), and DNA fragmentation.	sodium arsenite	155-170	poly (ADP-ribose) polymerase family, member 1	Mus musculus	251-278
10652248-2	2000	Previously, we showed that the cell death induced in day 9 mouse embryos by three teratogens, hyperthermia (HS), 4-hydroperoxycyclophosphamide (4-CP), and sodium arsenite (As), is apoptotic in nature involving the activation of caspase-3, cleavage of poly(ADP-ribose) polymerase (PARP), and DNA fragmentation.	sodium arsenite	155-170	poly (ADP-ribose) polymerase family, member 1	Mus musculus	280-284
10464319-4	1999	The pro-oxidants sodium arsenite, cadmium chloride, and hydrogen peroxide activated JNK1 with slow kinetics, whereas UV-B potentiated the activity of JNK1 rapidly.	sodium arsenite	17-32	mitogen-activated protein kinase 8	Homo sapiens	84-88
10774621-9	2000	Sodium arsenite-injected mice showed HSP-70 induction in the ileum that increased in a time-dependent manner with peak expression 12 h post-injection.	sodium arsenite	0-15	heat shock protein 1B	Mus musculus	37-43
10774621-11	2000	These data show that sodium arsenite induced HSP-70 expression in the small intestine.	sodium arsenite	21-36	heat shock protein 1B	Mus musculus	45-51
10600159-2	1999	Induction of heme oxygenase-1 can be caused by numerous factors, including heme, other metalloporphyrins, transition metal ions, heat shock, ultraviolet light, phorbol esters, sodium arsenite, and phenylarsine oxide (PAO).	sodium arsenite	176-191	heme oxygenase 1	Gallus gallus	13-29
10600159-4	1999	Using heme oxygenase-1 promoter/reporter gene constructs, we have previously reported that the sodium arsenite-mediated induction of heme oxygenase-1 in chick embryo liver cells and chicken hepatoma (LMH) cells involves an AP-1 element.	sodium arsenite	95-110	heme oxygenase 1	Gallus gallus	6-22
10600159-4	1999	Using heme oxygenase-1 promoter/reporter gene constructs, we have previously reported that the sodium arsenite-mediated induction of heme oxygenase-1 in chick embryo liver cells and chicken hepatoma (LMH) cells involves an AP-1 element.	sodium arsenite	95-110	heme oxygenase 1	Gallus gallus	133-149
10656165-3	1999	A significant reduction in plasma levels of LH, FSH and estrogen along with significant diminution in the activities of ovarian delta 5-3 beta-HSD and 17 beta-HSD were observed following sodium arsenite treatment for 28 days.	sodium arsenite	187-202	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	151-162
10701838-7	2000	Treatment of tailbud embryos with either sodium arsenite or zinc chloride induced a tissue-specific enrichment of hsp70 mRNA in the lens placode and somitic region.	sodium arsenite	41-56	heat shock protein family A (Hsp70) member 1 like S homeolog	Xenopus laevis	114-119
10542372-3	1999	When mouse blastocysts were exposed to the alkylating agent MMS, the metabolic inhibitor sodium arsenite or an inhibitor of protein glycosylation tunicamycin, levels of the CHOP-10 mRNA were increased by two- to threefold relative to the mRNA for beta-actin.	sodium arsenite	89-104	DNA-damage inducible transcript 3	Mus musculus	173-180
10542372-3	1999	When mouse blastocysts were exposed to the alkylating agent MMS, the metabolic inhibitor sodium arsenite or an inhibitor of protein glycosylation tunicamycin, levels of the CHOP-10 mRNA were increased by two- to threefold relative to the mRNA for beta-actin.	sodium arsenite	89-104	actin, beta	Mus musculus	247-257
10542372-6	1999	When F9 embryonal carcinoma cells were treated with MMS or sodium arsenite, CHOP-10 expression was induced by fourfold within 4 hr of treatment.	sodium arsenite	59-74	DNA-damage inducible transcript 3	Mus musculus	76-83
10521501-3	1999	We compared intracellular signaling mediating IL-8 gene expression in bronchial epithelial cells cultured in vitro and exposed to two inducers of cellular stress, sodium arsenite (As(III)), and vanadyl sulfate (V(IV)).	sodium arsenite	163-178	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
10466990-6	1999	Some vessels were treated with sodium arsenite (positive control, known to induce HSP70 expression).	sodium arsenite	31-46	heat shock protein family A (Hsp70) member 4	Homo sapiens	82-87
10445755-3	1999	In both rodent and human fibroblasts, DNA synthesis was found to be stimulated in cells exposed to a transient, sub-lethal concentration of sodium arsenite followed by stimulation with known RTK pathway activators.	sodium arsenite	140-155	ret proto-oncogene	Homo sapiens	191-194
10464058-6	1999	Treatment of the cells with sodium arsenite or subjecting them to hyperthermia induced the expression of hsp72.	sodium arsenite	28-43	heat shock protein family A (Hsp70) member 1A	Homo sapiens	105-110
10464058-7	1999	The IL-1beta-induced expression of C3 mRNA and C3 production were down-regulated by hyperthermia and sodium arsenite in a dose-dependent fashion.	sodium arsenite	101-116	interleukin 1 beta	Homo sapiens	4-12
10464058-8	1999	The results suggest that the stress response induced by hyperthermia or sodium arsenite decreases IL-1beta-induced C3 production in human enterocytes.	sodium arsenite	72-87	interleukin 1 beta	Homo sapiens	98-106
11721386-8	1999	CONCLUSION: Sodium arsenite selectively induced apoptosis of G2 + M phase NB4 cells, accompanied by upregulation of cyclin B1.	sodium arsenite	12-27	cyclin B1	Homo sapiens	116-125
10329507-2	1999	Here we investigated the effect of sodium arsenite on induction of CYP2B, CYP1A, and CYP3A in primary cultures of rat hepatocytes.	sodium arsenite	35-50	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	85-90
10329507-8	1999	With dexamethasone (DEX) as inducer, 5 microM sodium arsenite caused a 50% decrease in immunoreactive CYP3A and a 30% decrease in CYP3A23 mRNA.	sodium arsenite	46-61	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	102-107
10329507-8	1999	With dexamethasone (DEX) as inducer, 5 microM sodium arsenite caused a 50% decrease in immunoreactive CYP3A and a 30% decrease in CYP3A23 mRNA.	sodium arsenite	46-61	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	130-137
9837746-1	1998	We previously reported that PKN, a fatty acid-activated serine/threonine protein kinase, translocates from the cytosol to the nucleus by stresses such as heat shock, sodium arsenite, and serum starvation.	sodium arsenite	166-181	protein kinase N1	Homo sapiens	28-31
10221768-3	1999	The cellular stress agents sodium arsenite and hyperosmotic sorbitol significantly stimulated p38 MAPK activity, as did the tyrosine phosphatase inhibitor sodium pervanadate and the serine/threonine phosphatase inhibitor okadaic acid.	sodium arsenite	27-42	mitogen activated protein kinase 14	Rattus norvegicus	94-97
10197422-5	1999	The cell-free extract of Clostridium sporogenes had debrominating activity in the presence of both FMN and NADH (or NADPH), and this activity was inhibited by sodium arsenite and potassium cyanide.	sodium arsenite	159-174	2,4-dienoyl-CoA reductase 1	Homo sapiens	116-121
9820195-7	1998	Limiting expression of Hsp70-1/3 with 5 microM A070-1/3 also heightened embryo sensitivity to arsenic, resulting in less than 5% in vitro development to blastocyst in the presence of the subtoxic dose of 0.4 microM sodium arsenite.	sodium arsenite	215-230	heat shock protein 1A	Mus musculus	23-32
10319276-0	1999	Sodium arsenite reduces proliferation of human activated T-cells by inhibition of the secretion of interleukin-2.	sodium arsenite	0-15	interleukin 2	Homo sapiens	99-112
10319276-9	1999	These alterations suggest that due to sodium arsenite effects on cytoskeleton, the intracellular secretion of proteins is affected, including the one of IL-2, leading to an impaired proliferation of the T cells when stimulated with PHA.	sodium arsenite	38-53	interleukin 2	Homo sapiens	153-157
10216529-2	1999	METHODS: Hsp-73 expression was induced in rat small intestine with use of sodium arsenite injected (6 mg/kg) through a catheter cannulated into the left common carotid artery 24 hours before ischemia (group 1).	sodium arsenite	74-89	selenoprotein K	Rattus norvegicus	9-12
9927172-3	1999	hsp70 functioned well when induced by heat shock and was also induced to a lesser extent by chemicals such as sodium arsenite.	sodium arsenite	110-125	heat shock protein 1B	Mus musculus	0-5
9837857-1	1998	Heme oxygenase 1 (HO-1), a stress response protein, is highly induced in response to various agents causing oxidative stress including ultraviolet irradiation, sodium arsenite, hyperoxia, and glutathione depletors.	sodium arsenite	160-175	heme oxygenase 1	Rattus norvegicus	0-16
9837857-1	1998	Heme oxygenase 1 (HO-1), a stress response protein, is highly induced in response to various agents causing oxidative stress including ultraviolet irradiation, sodium arsenite, hyperoxia, and glutathione depletors.	sodium arsenite	160-175	heme oxygenase 1	Rattus norvegicus	18-22
9747510-7	1998	In addition to hyperoxia, sodium arsenite (NaAsO2), cadmium chloride (CdCl(2)) and hydrogen peroxide (H2O2), which are reactive oxygen intermediates (ROI) generators, increased the HO-1 mRNA level by 11-, 22- and 2.5-fold, respectively.	sodium arsenite	26-41	heme oxygenase 1	Homo sapiens	181-185
9747510-7	1998	In addition to hyperoxia, sodium arsenite (NaAsO2), cadmium chloride (CdCl(2)) and hydrogen peroxide (H2O2), which are reactive oxygen intermediates (ROI) generators, increased the HO-1 mRNA level by 11-, 22- and 2.5-fold, respectively.	sodium arsenite	43-49	heme oxygenase 1	Homo sapiens	181-185
9722676-0	1998	Involvement of the tyrosine phosphorylation pathway in induction of human heme oxygenase-1 by hemin, sodium arsenite, and cadmium chloride.	sodium arsenite	101-116	heme oxygenase 1	Homo sapiens	74-90
9722676-1	1998	The effect of a tyrosine kinase inhibitor, herbimycin A, on the induction of heme oxygenase-1 (HO-1) mRNA in HeLa cells upon exposure to hemin, sodium arsenite and cadmium chloride was examined.	sodium arsenite	144-159	heme oxygenase 1	Homo sapiens	77-93
9722676-1	1998	The effect of a tyrosine kinase inhibitor, herbimycin A, on the induction of heme oxygenase-1 (HO-1) mRNA in HeLa cells upon exposure to hemin, sodium arsenite and cadmium chloride was examined.	sodium arsenite	144-159	heme oxygenase 1	Homo sapiens	95-99
9653069-1	1998	In earlier studies, treatment with sodium arsenite was shown to decrease total hepatic CYP in rats.	sodium arsenite	35-50	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	87-90
9671412-4	1998	Here we report that in NIH3T3 cells, egr-1 is induced by various stress treatments such as heat shock, sodium arsenite, ultraviolet (U.V.)	sodium arsenite	103-118	early growth response 1	Mus musculus	37-42
9712902-6	1998	In this regard, we show that treatment with sodium arsenite, a known activator of p38 MAP kinases, also stimulates expression from the PEPCK promoter.	sodium arsenite	44-59	mitogen-activated protein kinase 14	Homo sapiens	82-85
9712902-6	1998	In this regard, we show that treatment with sodium arsenite, a known activator of p38 MAP kinases, also stimulates expression from the PEPCK promoter.	sodium arsenite	44-59	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	135-140
9671310-1	1998	Pretreatment of cells with 0.5 mM sodium arsenite (but not other activators of stress-activated MAP kinase cascades) prevents the activation of p21Ras and strongly suppresses the activation of c-Raf and the MAP kinase cascade by a variety of growth factors.	sodium arsenite	34-49	HRas proto-oncogene, GTPase	Homo sapiens	144-150
9671310-1	1998	Pretreatment of cells with 0.5 mM sodium arsenite (but not other activators of stress-activated MAP kinase cascades) prevents the activation of p21Ras and strongly suppresses the activation of c-Raf and the MAP kinase cascade by a variety of growth factors.	sodium arsenite	34-49	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	193-198
10200514-3	1998	We show that three teratogens, hyperthermia, cyclophosphamide and sodium arsenite induce an increase in cell death in day 9.0 mouse embryos with concurrent induction of DNA fragmentation, activation of caspase-3 and the cleavage of poly (ADP-ribose) polymerase (PARP).	sodium arsenite	66-81	caspase 3	Mus musculus	202-211
10200514-3	1998	We show that three teratogens, hyperthermia, cyclophosphamide and sodium arsenite induce an increase in cell death in day 9.0 mouse embryos with concurrent induction of DNA fragmentation, activation of caspase-3 and the cleavage of poly (ADP-ribose) polymerase (PARP).	sodium arsenite	66-81	poly (ADP-ribose) polymerase family, member 1	Mus musculus	232-260
10200514-3	1998	We show that three teratogens, hyperthermia, cyclophosphamide and sodium arsenite induce an increase in cell death in day 9.0 mouse embryos with concurrent induction of DNA fragmentation, activation of caspase-3 and the cleavage of poly (ADP-ribose) polymerase (PARP).	sodium arsenite	66-81	poly (ADP-ribose) polymerase family, member 1	Mus musculus	262-266
9653069-5	1998	Near maximal decreases were observed in these forms of CYP at a concentration of 2.5 microM sodium arsenite.	sodium arsenite	92-107	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	55-58
9604300-11	1998	With liver slices produced by both tissue slicers 50 microM sodium arsenite produced a greater induction of heat shock protein 70 levels in slices cultured for 24 h in a high oxygen than in an air atmosphere.	sodium arsenite	60-75	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	108-129
9535875-0	1998	Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells.	sodium arsenite	13-28	heme oxygenase 1	Gallus gallus	51-67
9535875-4	1998	We identified a heme oxygenase-1 promoter-driven luciferase reporter construct that was highly and reproducibly expressed in response to sodium arsenite treatment.	sodium arsenite	137-152	heme oxygenase 1	Gallus gallus	16-32
9535875-6	1998	In LMH cells, sodium arsenite, cadmium, and heat shock, but not heme, induced activity of the MAP kinases extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38.	sodium arsenite	14-29	adapter molecule crk	Gallus gallus	179-182
9403530-8	1997	Induction of HSP 70 in T-cell clones with sodium arsenite had a similar protective effect against radiation-induced apoptosis.	sodium arsenite	42-57	heat shock protein 1B	Mus musculus	13-19
10099789-5	1998	Furthermore, the optimal temperature of BShsp induction, temporal pattern of synthesis, and induction of BShsps by other stressors such as herbimycin A and sodium arsenite were similar to those reported for the acidic hsp30 family.	sodium arsenite	156-171	heat shock protein 30E L homeolog	Xenopus laevis	218-223
9276477-6	1997	We show here that expression of the NTH1 gene and its product, neutral trehalase (Nthlp), are also induced by other stressors such as H2O2, CuSO4, NaAsO2, and cycloheximide (CHX).	sodium arsenite	147-153	alpha,alpha-trehalase NTH1	Saccharomyces cerevisiae S288C	36-40
9299480-0	1997	p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for phosphatidylinositol 3-kinase and p38 MAP kinase.	sodium arsenite	30-45	ribosomal protein S6 kinase B1	Rattus norvegicus	0-13
9434882-0	1997	Induction of p53 protein expression by sodium arsenite.	sodium arsenite	39-54	tumor protein p53	Homo sapiens	13-16
9434882-3	1997	Intrigued by these effects and based on the role of p53 on cell proliferation, we tested different concentrations of sodium arsenite for their ability to induce the expression of tumor suppressor gene p53 in different cell lines (HeLa, C-33A.	sodium arsenite	117-132	tumor protein p53	Homo sapiens	52-55
9434882-3	1997	Intrigued by these effects and based on the role of p53 on cell proliferation, we tested different concentrations of sodium arsenite for their ability to induce the expression of tumor suppressor gene p53 in different cell lines (HeLa, C-33A.	sodium arsenite	117-132	tumor protein p53	Homo sapiens	201-204
9434882-6	1997	Immunoblots showed an increased expression of p53 gene with 1 microM sodium arsenite in Jurkat cells and 10 microM sodium arsenite in HeLa and LCL-EBV cells.	sodium arsenite	69-84	tumor protein p53	Homo sapiens	46-49
9434882-6	1997	Immunoblots showed an increased expression of p53 gene with 1 microM sodium arsenite in Jurkat cells and 10 microM sodium arsenite in HeLa and LCL-EBV cells.	sodium arsenite	115-130	tumor protein p53	Homo sapiens	46-49
9288946-1	1997	Sodium arsenite and osmotic shock both stimulated stress-activated protein kinase-2 (SAPK2, also termed RK, p38, CSBP and Mxi2) and its downstream target mitogen-activated protein kinase (MAP kinase)-activated protein kinase-2 (MAPKAP-K2) in bovine adrenal chromaffin and rat PC12 cells.	sodium arsenite	0-15	mitogen-activated protein kinase 14	Bos taurus	108-111
9288946-1	1997	Sodium arsenite and osmotic shock both stimulated stress-activated protein kinase-2 (SAPK2, also termed RK, p38, CSBP and Mxi2) and its downstream target mitogen-activated protein kinase (MAP kinase)-activated protein kinase-2 (MAPKAP-K2) in bovine adrenal chromaffin and rat PC12 cells.	sodium arsenite	0-15	MAPK activated protein kinase 2	Bos taurus	154-226
9288946-1	1997	Sodium arsenite and osmotic shock both stimulated stress-activated protein kinase-2 (SAPK2, also termed RK, p38, CSBP and Mxi2) and its downstream target mitogen-activated protein kinase (MAP kinase)-activated protein kinase-2 (MAPKAP-K2) in bovine adrenal chromaffin and rat PC12 cells.	sodium arsenite	0-15	MAPK activated protein kinase 2	Bos taurus	228-237
9176145-5	1997	Sodium arsenite at 80-320 microM, which induced heat shock protein 72 (HSP72) expression and reactive oxygen intermediate (ROI) generation in ECs, resulted in EC apoptosis.	sodium arsenite	0-15	heat shock protein family A (Hsp70) member 1A	Homo sapiens	48-69
9219564-3	1997	We found that exposure of human lung adenocarcinoma A549 cells to sodium arsenite (0.08-2 microM) or sodium arsenate (30-300 microM), but not dimethylarsenic acid (2-2000 microM), produced significant dose-responsive hypermethylation within a 341-base pair fragment of the promoter of p53.	sodium arsenite	66-81	tumor protein p53	Homo sapiens	285-288
9219571-8	1997	The effect of treatment with sodium arsenite on PARP activity was assessed as follows: Molt-3 cells (a human T-cell lymphoma-derived cell line) in culture were treated for 24 h with concentrations of sodium arsenite ranging from 2.5 up to 25 microM.	sodium arsenite	29-44	poly(ADP-ribose) polymerase 1	Homo sapiens	48-52
9176145-5	1997	Sodium arsenite at 80-320 microM, which induced heat shock protein 72 (HSP72) expression and reactive oxygen intermediate (ROI) generation in ECs, resulted in EC apoptosis.	sodium arsenite	0-15	heat shock protein family A (Hsp70) member 1A	Homo sapiens	71-76
9176145-7	1997	Heat shock alone (42 degrees C, 45 min) or sodium arsenite (40 microM) alone, each of which induced HSP72 expression, did not result in EC apoptosis.	sodium arsenite	43-58	heat shock protein family A (Hsp70) member 1A	Homo sapiens	100-105
9176145-8	1997	However, the combination of TNF-alpha with heat shock or 40 microM sodium arsenite led to EC apoptosis as HSP72 expression and ROI were induced.	sodium arsenite	67-82	heat shock protein family A (Hsp70) member 1A	Homo sapiens	106-111
8971075-3	1997	We now show that oxidative and chemical stress (hydrogen peroxide and sodium meta-arsenite, respectively) also produce a dominant inhibitory effect, both on the endogenous PEPCK gene and on a stably transfected PEPCK-chloramphenicol acetyl transferase (CAT) fusion gene.	sodium arsenite	70-90	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	172-177
8971075-3	1997	We now show that oxidative and chemical stress (hydrogen peroxide and sodium meta-arsenite, respectively) also produce a dominant inhibitory effect, both on the endogenous PEPCK gene and on a stably transfected PEPCK-chloramphenicol acetyl transferase (CAT) fusion gene.	sodium arsenite	70-90	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	211-216
8971075-5	1997	Thus, the mechanism(s) used by hydrogen peroxide and sodium meta-arsenite to regulate PEPCK gene expression are PI 3-kinase independent.	sodium arsenite	53-73	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	86-91
8971075-5	1997	Thus, the mechanism(s) used by hydrogen peroxide and sodium meta-arsenite to regulate PEPCK gene expression are PI 3-kinase independent.	sodium arsenite	53-73	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	112-123
8971075-7	1997	The reactivating kinase (RK, also known as p38 mitogen activated protein kinase) is induced by insulin, hydrogen peroxide, or sodium meta-arsenite in hepatoma cells, and these effects are blocked by SB203580, a selective inhibitor of RK.	sodium arsenite	126-146	mitogen-activated protein kinase 14	Homo sapiens	43-46
8969269-6	1996	Exposure of SPAEC to either heat (43 degrees C, 90 min) or sodium arsenite (100 microM, 90 min) induced expression of heat-shock protein-70 (HSP-70).	sodium arsenite	59-74	heat shock 70 kDa protein 1A/1B	Ovis aries	118-139
9261921-1	1997	In a previous study, we found that sodium arsenite increased hepatic ornithine decarboxylase (ODC) activity and hepatic heme oxygenase (HO) activity, but did not cause any DNA damage in adult female rat liver or lung, suggesting that arsenite may be a promoter of carcinogenesis.	sodium arsenite	35-50	ornithine decarboxylase 1	Rattus norvegicus	69-92
9261921-1	1997	In a previous study, we found that sodium arsenite increased hepatic ornithine decarboxylase (ODC) activity and hepatic heme oxygenase (HO) activity, but did not cause any DNA damage in adult female rat liver or lung, suggesting that arsenite may be a promoter of carcinogenesis.	sodium arsenite	35-50	ornithine decarboxylase 1	Rattus norvegicus	94-97
8969269-6	1996	Exposure of SPAEC to either heat (43 degrees C, 90 min) or sodium arsenite (100 microM, 90 min) induced expression of heat-shock protein-70 (HSP-70).	sodium arsenite	59-74	heat shock 70 kDa protein 1A/1B	Ovis aries	141-147
8903404-6	1996	Sodium arsenite (Ars) or hyperthermia (43 degrees C) induced the synthesis of hsp72 messenger RNA (mRNA) and protein in hepatocytes, indicating activation of the HSR.	sodium arsenite	0-15	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	78-83
8970379-4	1996	In contrast, rats exposed to heat stress or to sodium arsenite 18 h prior to LPS had significantly lower levels of plasma TNF-alpha.	sodium arsenite	47-62	tumor necrosis factor	Rattus norvegicus	122-131
8751576-6	1996	RESULTS: Sodium arsenite or hyperthermia induced the synthesis of hsp70 protein in AKN-1 cells, indicating activation of the HSR.	sodium arsenite	9-24	heat shock protein family A (Hsp70) member 4	Homo sapiens	66-71
8917704-3	1996	Treatment with sodium arsenite resulted in a significant increase in cell proliferation, as indicated by increases in cell numbers, c-myc gene expression, and incorporation of [3H]thymidine into cellular DNA.	sodium arsenite	15-30	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	132-137
8798781-7	1996	We now report that sodium arsenite, a prototype for stressors fostering cytoplasmic protein misfolding, also inhibits translational initiation through activation of PKR while subsequently inducing the heat shock protein (HSP) chaperones.	sodium arsenite	19-34	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	165-168
8798781-7	1996	We now report that sodium arsenite, a prototype for stressors fostering cytoplasmic protein misfolding, also inhibits translational initiation through activation of PKR while subsequently inducing the heat shock protein (HSP) chaperones.	sodium arsenite	19-34	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	201-219
8798781-7	1996	We now report that sodium arsenite, a prototype for stressors fostering cytoplasmic protein misfolding, also inhibits translational initiation through activation of PKR while subsequently inducing the heat shock protein (HSP) chaperones.	sodium arsenite	19-34	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	221-224
8917706-0	1996	Expression of the 25-kDa heat-shock protein (HSP27) correlates with resistance to the toxicity of cadmium chloride, mercuric chloride, cis-platinum(II)-diammine dichloride, or sodium arsenite in mouse embryonic stem cells transfected with sense or antisense HSP27 cDNA.	sodium arsenite	176-191	heat shock protein 1	Mus musculus	45-50
8917706-3	1996	Compared to the parental ES cell lines or ES cells transfected with the vector lacking any HSP27 sequence, all ES cell lines overexpressing HSP27 were resistant to killing by cadmium chloride (CdCl2), mercuric chloride (HgCl2), cis-platinum(II)-diammine dichloride (cDDP), sodium arsenite (NaAsO2), and heat while ES cell lines expressing reduced HSP27 were more sensitive to metal toxicity and heat.	sodium arsenite	273-288	heat shock protein 1	Mus musculus	140-145
8917706-3	1996	Compared to the parental ES cell lines or ES cells transfected with the vector lacking any HSP27 sequence, all ES cell lines overexpressing HSP27 were resistant to killing by cadmium chloride (CdCl2), mercuric chloride (HgCl2), cis-platinum(II)-diammine dichloride (cDDP), sodium arsenite (NaAsO2), and heat while ES cell lines expressing reduced HSP27 were more sensitive to metal toxicity and heat.	sodium arsenite	273-288	heat shock protein 1	Mus musculus	140-145
8917706-3	1996	Compared to the parental ES cell lines or ES cells transfected with the vector lacking any HSP27 sequence, all ES cell lines overexpressing HSP27 were resistant to killing by cadmium chloride (CdCl2), mercuric chloride (HgCl2), cis-platinum(II)-diammine dichloride (cDDP), sodium arsenite (NaAsO2), and heat while ES cell lines expressing reduced HSP27 were more sensitive to metal toxicity and heat.	sodium arsenite	290-296	heat shock protein 1	Mus musculus	140-145
8917706-3	1996	Compared to the parental ES cell lines or ES cells transfected with the vector lacking any HSP27 sequence, all ES cell lines overexpressing HSP27 were resistant to killing by cadmium chloride (CdCl2), mercuric chloride (HgCl2), cis-platinum(II)-diammine dichloride (cDDP), sodium arsenite (NaAsO2), and heat while ES cell lines expressing reduced HSP27 were more sensitive to metal toxicity and heat.	sodium arsenite	290-296	heat shock protein 1	Mus musculus	140-145
8841493-1	1996	In this study, we have examined the mutagenicity of sodium arsenite at the xanthine-guanine phosphoribosyltransferase locus (ypt) in a pSV2 gpt-transformed CHO cell line, AS52.	sodium arsenite	52-67	alanine aminotransferase 1	Cricetulus griseus	140-143
8816775-6	1996	The nuclear localization of PKN was also observed when the cells were exposed to other stresses such as sodium arsenite and serum starvation.	sodium arsenite	104-119	protein kinase N1	Mus musculus	28-31
8875078-7	1996	Injection of sodium arsenite into mice resulted in increased endogenous alpha B-crystallin expression in the adrenal gland and possibly the liver.	sodium arsenite	13-28	crystallin, alpha B	Mus musculus	72-90
9222590-6	1996	While heat shock and sodium arsenite exposure resulted in the increased accumulation of hsp90 mRNA in A6 cells, treatment with cadmium chloride and zinc chloride did not.	sodium arsenite	21-36	heat shock protein HSP 90-beta	Xenopus laevis	88-93
8662954-4	1996	In this report we have demonstrated that treatment of rat pheochromocytoma PC12 cells with sodium arsenite leads to enhanced expression of C/EBP-beta and GADD153 (growth arrest and DNA damage inducible gene 153) but not other C/EBPs.	sodium arsenite	91-106	CCAAT/enhancer binding protein beta	Rattus norvegicus	139-149
8662954-4	1996	In this report we have demonstrated that treatment of rat pheochromocytoma PC12 cells with sodium arsenite leads to enhanced expression of C/EBP-beta and GADD153 (growth arrest and DNA damage inducible gene 153) but not other C/EBPs.	sodium arsenite	91-106	DNA-damage inducible transcript 3	Rattus norvegicus	154-161
8662954-4	1996	In this report we have demonstrated that treatment of rat pheochromocytoma PC12 cells with sodium arsenite leads to enhanced expression of C/EBP-beta and GADD153 (growth arrest and DNA damage inducible gene 153) but not other C/EBPs.	sodium arsenite	91-106	DNA-damage inducible transcript 3	Rattus norvegicus	163-210
8645700-8	1996	The induction of heme oxygenase-1 was assessed by measuring changes in mRNA levels or enzyme activities in response to several treatments, including heme, heavy metals, sodium arsenite, and heat shock, which have been shown to increase the expression of heme oxygenase.	sodium arsenite	169-184	heme oxygenase 1	Gallus gallus	17-33
8663271-3	1996	In this study, we report that the calcium ionophore A23187, a glucose-regulated protein (GRP) inducer, dramatically inhibits HSP70 synthesis and HSP70 mRNA transcription after induction by heat shock, sodium arsenite, or prostaglandin A1 treatment in human K562 cells.	sodium arsenite	201-216	gastrin releasing peptide	Homo sapiens	62-87
8663271-3	1996	In this study, we report that the calcium ionophore A23187, a glucose-regulated protein (GRP) inducer, dramatically inhibits HSP70 synthesis and HSP70 mRNA transcription after induction by heat shock, sodium arsenite, or prostaglandin A1 treatment in human K562 cells.	sodium arsenite	201-216	gastrin releasing peptide	Homo sapiens	89-92
8836877-1	1996	Exposure of osteoblast-like MC3T3-E1 cells to sodium arsenite (arsenite) increased the level of heat shock protein 27 (hsp27).	sodium arsenite	46-61	heat shock protein 1	Mus musculus	96-117
8836877-1	1996	Exposure of osteoblast-like MC3T3-E1 cells to sodium arsenite (arsenite) increased the level of heat shock protein 27 (hsp27).	sodium arsenite	46-61	heat shock protein 1	Mus musculus	119-124
9222590-7	1996	Also, exposure of A6 cells to concurrent heat shock and sodium arsenite produced a mild synergistic response with respect to hsp90 mRNA levels in contrast to hsp70 mRNA levels which displayed a strong synergistic effect.	sodium arsenite	56-71	heat shock protein HSP 90-beta	Xenopus laevis	125-130
8902523-3	1996	In the present study, we examined ERK, JNK/SAPK, and p38 activation in cells treated with the sulfhydryl-reactive agent sodium arsenite.	sodium arsenite	120-135	Eph receptor B1	Rattus norvegicus	34-37
8556709-4	1996	We observed that the activated Raf significantly potentiated the induction of MDRCAT activity in GHE-L cells by sodium arsenite or heat shock, which stimulates heat shock factor (HSF) binding to HSE.	sodium arsenite	112-127	zinc fingers and homeoboxes 2	Homo sapiens	31-34
8556709-4	1996	We observed that the activated Raf significantly potentiated the induction of MDRCAT activity in GHE-L cells by sodium arsenite or heat shock, which stimulates heat shock factor (HSF) binding to HSE.	sodium arsenite	112-127	interleukin 6	Homo sapiens	179-182
8556713-4	1996	Sodium arsenite increased rat hepatic ODC activity at 1.6 and 24.6 mg/kg and hepatic heme oxygenase activity at 8.2 and 24.6 mg/kg, but did not cause any DNA damage.	sodium arsenite	0-15	ornithine decarboxylase 1	Rattus norvegicus	38-41
8874798-4	1996	Treatment of the transfected cells with transition metallic ions (cadmium, cobalt, and zinc) or sodium arsenite produced increases in activities of luciferase or chloramphenicol acetyl transferase, relative to beta-galactosidase, and this activity mapped to the first 122 base pairs of the promoter.	sodium arsenite	96-111	galactosidase beta 1	Gallus gallus	210-228
8874798-7	1996	We conclude that the heme-dependent induction of the liver metallothionein gene depends upon DNA region(s) outside the regulatory region of the chick metallothionein gene studied here and that elements within the first 122 base pairs of the metallothionein promoter are sufficient to confer responsiveness to transition metals or sodium arsenite.	sodium arsenite	330-345	metallothionein 4	Gallus gallus	59-74
8902523-3	1996	In the present study, we examined ERK, JNK/SAPK, and p38 activation in cells treated with the sulfhydryl-reactive agent sodium arsenite.	sodium arsenite	120-135	mitogen-activated protein kinase 8	Rattus norvegicus	39-47
8902523-3	1996	In the present study, we examined ERK, JNK/SAPK, and p38 activation in cells treated with the sulfhydryl-reactive agent sodium arsenite.	sodium arsenite	120-135	mitogen activated protein kinase 14	Rattus norvegicus	53-56
8572246-3	1995	Exposure of RPASMC to sodium arsenite or heat led to expression of heat shock protein-70 (HSP-70) in a time- and concentration-dependent manner.	sodium arsenite	22-37	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	67-88
8717371-3	1996	Recently we demonstrated [4] that stress, in the form of heat shock, ethanol and sodium arsenite treatment, transcriptionally activates the beta-APP gene.	sodium arsenite	81-96	amyloid beta precursor protein	Homo sapiens	140-148
8572246-3	1995	Exposure of RPASMC to sodium arsenite or heat led to expression of heat shock protein-70 (HSP-70) in a time- and concentration-dependent manner.	sodium arsenite	22-37	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	90-96
7899564-2	1995	Thermotolerance as determined by clonogenic survival was induced not only by prior heating at 44 degrees C for 30 min but also by prior treatment with 100 microM sodium arsenite for 1 h and 5 micrograms/ml prostaglandin J2 for 4 h. These treatments concomitantly induced both hsp-70 (p72, inducible form) and hsp-40.	sodium arsenite	162-177	heat shock protein 1B	Mus musculus	276-282
8647995-3	1995	In the present study, we examined the effects of heat, chemicals (azetidine and sodium arsenite), ultraviolet (UV) light, and gamma-ray irradiation on the induction of HSP72 in cultured human skin melanoma cell lines (P-39 and G-361), a human skin squamous cell carcinoma cell line (HSC-1), and an SV40-transformed human lung fibroblast cell line (WI38VA13) as a control.	sodium arsenite	80-95	heat shock protein family A (Hsp70) member 1A	Homo sapiens	168-173
7729015-4	1995	Treatment of RASMCs with hemin and sodium arsenite, which are inducers of HO-1, stimulated RASMC cGMP without stimulating nitrite release or inducible NO synthase expression, and the induced elevations of cGMP were not inhibited by the NO synthase inhibitor NG-methyl-L-arginine.	sodium arsenite	35-50	heme oxygenase 1	Rattus norvegicus	74-78
7729015-4	1995	Treatment of RASMCs with hemin and sodium arsenite, which are inducers of HO-1, stimulated RASMC cGMP without stimulating nitrite release or inducible NO synthase expression, and the induced elevations of cGMP were not inhibited by the NO synthase inhibitor NG-methyl-L-arginine.	sodium arsenite	35-50	nitric oxide synthase 2	Rattus norvegicus	141-162
7492272-9	1995	Expression of HSP-72 was detected after ECs were treated both with heat shock and sodium arsenite (40 to 320 mumol/L) for 6 hours.	sodium arsenite	82-97	heat shock protein family A (Hsp70) member 1A	Homo sapiens	14-20
7899564-2	1995	Thermotolerance as determined by clonogenic survival was induced not only by prior heating at 44 degrees C for 30 min but also by prior treatment with 100 microM sodium arsenite for 1 h and 5 micrograms/ml prostaglandin J2 for 4 h. These treatments concomitantly induced both hsp-70 (p72, inducible form) and hsp-40.	sodium arsenite	162-177	DEAD box helicase 17	Mus musculus	284-287
7899564-2	1995	Thermotolerance as determined by clonogenic survival was induced not only by prior heating at 44 degrees C for 30 min but also by prior treatment with 100 microM sodium arsenite for 1 h and 5 micrograms/ml prostaglandin J2 for 4 h. These treatments concomitantly induced both hsp-70 (p72, inducible form) and hsp-40.	sodium arsenite	162-177	DnaJ heat shock protein family (Hsp40) member B1	Mus musculus	309-315
8526746-7	1995	Furthermore, sodium arsenite treatment did not apparently affect glucose-6-phosphate dehydrogenase activity, but resulted in significantly increased glutathione levels and superoxide dismutase activity, slightly decreased glutathione peroxidase activity, and significantly decreased catalase activity.	sodium arsenite	13-28	catalase	Homo sapiens	283-291
8526746-8	1995	Sodium arsenite toxicity was partly reduced by addition of catalase to the culture medium.	sodium arsenite	0-15	catalase	Homo sapiens	59-67
7858064-5	1994	Treatment of FS-4 cells with sodium arsenite led to a very strong increase in the phosphorylation of Hsp28 demonstrable after 5 min and persisting for at least 4 h. Tyrosine phosphorylation of pp42 and pp44 MAP kinases was increased by TNF treatment, whereas arsenite produced a modest increase in tyrosine phosphorylation of pp44 while decreasing that of pp42 MAP kinase.	sodium arsenite	29-44	heat shock protein family B (small) member 1	Homo sapiens	101-106
7600446-0	1995	Selective increase of rat lung cytochrome P450 1A1 dependent monooxygenase activity after acute sodium arsenite administration.	sodium arsenite	96-111	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	31-50
7737136-5	1995	Sodium arsenite treatment also inhibited the activities of serine/threonine protein phosphatases and enhanced phosphorylation levels of a small heat shock protein (HSP27).	sodium arsenite	0-15	heat shock protein family B (small) member 1	Homo sapiens	164-169
7955528-3	1994	In the FRTL5 rat cell line, which had been heated at 42.5 degrees C or treated with sodium arsenite, expression of hsp-72 was examined with immunoperoxidase staining and immunoprecipitation of the metabolically labelled protein using a specific MoAb.	sodium arsenite	84-99	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	115-121
7933069-6	1994	The possibility that HSP70 could be a mediator of the antiviral effect is suggested by the fact that treatment with other classical inducers of HSP70, including sodium arsenite, cadmium, and heat shock at 42 degrees C for 5 h, also selectively prevented SV protein synthesis as long as heat shock protein synthesis occurred.	sodium arsenite	161-176	heat shock protein 1B	Mus musculus	21-26
7933069-6	1994	The possibility that HSP70 could be a mediator of the antiviral effect is suggested by the fact that treatment with other classical inducers of HSP70, including sodium arsenite, cadmium, and heat shock at 42 degrees C for 5 h, also selectively prevented SV protein synthesis as long as heat shock protein synthesis occurred.	sodium arsenite	161-176	heat shock protein 1B	Mus musculus	144-149
7858064-5	1994	Treatment of FS-4 cells with sodium arsenite led to a very strong increase in the phosphorylation of Hsp28 demonstrable after 5 min and persisting for at least 4 h. Tyrosine phosphorylation of pp42 and pp44 MAP kinases was increased by TNF treatment, whereas arsenite produced a modest increase in tyrosine phosphorylation of pp44 while decreasing that of pp42 MAP kinase.	sodium arsenite	29-44	tumor necrosis factor	Homo sapiens	236-239
7858064-6	1994	The finding that sodium arsenite strongly increased Hsp28 phosphorylation, together with the resistance of TNF-induced phosphorylation to kinase inhibitors, supports the notion that increased serine phosphorylation of Hsp28 in this system involves inhibition of protein phosphatase activity.	sodium arsenite	17-32	heat shock protein family B (small) member 1	Homo sapiens	52-57
7858064-6	1994	The finding that sodium arsenite strongly increased Hsp28 phosphorylation, together with the resistance of TNF-induced phosphorylation to kinase inhibitors, supports the notion that increased serine phosphorylation of Hsp28 in this system involves inhibition of protein phosphatase activity.	sodium arsenite	17-32	heat shock protein family B (small) member 1	Homo sapiens	218-223
7983179-2	1994	Our data show that chemical treatments including sodium arsenite, cadmium chloride and sodium salicylate, induced significant synthesis of hsp70 and its mRNA.	sodium arsenite	49-64	heat shock protein 1B	Mus musculus	139-144
7735982-0	1994	Effect of ethanol and sodium arsenite on HSP-72 formation and on survival in a murine endotoxin model.	sodium arsenite	22-37	heat shock protein 1A	Mus musculus	41-47
7735982-3	1994	The purpose of this study was to determine if in vivo administration of sodium arsenite (NaAsO2) or ethanol, inducers of HSPs in isolated cells, induced HSP-72 production in lung, liver, kidney, and duodenum (organs known to induce HSP-72 by heat) and improved survival from endotoxin.	sodium arsenite	72-87	heat shock protein 1A	Mus musculus	153-159
7735982-3	1994	The purpose of this study was to determine if in vivo administration of sodium arsenite (NaAsO2) or ethanol, inducers of HSPs in isolated cells, induced HSP-72 production in lung, liver, kidney, and duodenum (organs known to induce HSP-72 by heat) and improved survival from endotoxin.	sodium arsenite	72-87	heat shock protein 1A	Mus musculus	232-238
7735982-3	1994	The purpose of this study was to determine if in vivo administration of sodium arsenite (NaAsO2) or ethanol, inducers of HSPs in isolated cells, induced HSP-72 production in lung, liver, kidney, and duodenum (organs known to induce HSP-72 by heat) and improved survival from endotoxin.	sodium arsenite	89-95	heat shock protein 1A	Mus musculus	153-159
7735982-3	1994	The purpose of this study was to determine if in vivo administration of sodium arsenite (NaAsO2) or ethanol, inducers of HSPs in isolated cells, induced HSP-72 production in lung, liver, kidney, and duodenum (organs known to induce HSP-72 by heat) and improved survival from endotoxin.	sodium arsenite	89-95	heat shock protein 1A	Mus musculus	232-238
7735982-7	1994	Ethanol induced HSP-72 in kidney, 50% that of the standard (i.e., pooled livers isolated from heat-treated mice); NaAsO2 induced HSP-72 in kidney (approximately 50% of standard) and liver (approximately 21% of standard).	sodium arsenite	114-120	heat shock protein 1A	Mus musculus	129-135
8464927-2	1993	Our studies on the response of rodent cells to heat shock or sodium arsenite indicate that a high level of HSF-DNA-binding activity, by itself, is not sufficient for the induction of hsp70 mRNA synthesis; furthermore, a high level of HSF binding is also not necessary for this induction.	sodium arsenite	61-76	interleukin 6	Homo sapiens	107-110
8187816-5	1994	Both the mRNA levels and the secretion of osteonectin increased concurrently when Pam and HSC-1 cells cultured in low calcium medium were exposed to various stresses including heat shock and treatment with sodium arsenite or L-azetidine-2-carboxylic acid.	sodium arsenite	206-221	secreted acidic cysteine rich glycoprotein	Mus musculus	42-53
8187816-5	1994	Both the mRNA levels and the secretion of osteonectin increased concurrently when Pam and HSC-1 cells cultured in low calcium medium were exposed to various stresses including heat shock and treatment with sodium arsenite or L-azetidine-2-carboxylic acid.	sodium arsenite	206-221	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	82-85
7794296-11	1994	CONCLUSIONS: We conclude that in vivo injection of sodium arsenite induces expression of HSP-72 in the lungs, and confers transient protection against experimental sepsis during the period that heat shock proteins are also expressed.	sodium arsenite	51-66	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	89-95
7930803-6	1994	Our studies show that HSF-1 is phosphorylated following heat shock (43 degrees C for 1 h), hypoxia (5 h exposure to 0.02% oxygen), 8% ethanol (1 h exposure at 37 degrees C), or 200 microM sodium arsenite (1 h exposure at 37 degrees C).	sodium arsenite	188-203	heat shock transcription factor 1	Homo sapiens	22-27
8157658-3	1994	Exposure of cells to chemical stressors, namely, NaAsO2 and CdCl2, also enhanced the dissociation of L-hsp27.	sodium arsenite	49-55	heat shock protein family B (small) member 1	Homo sapiens	103-108
8355691-5	1993	HSF activation in response to treatment with sodium arsenite or the proline analog azetidine was also depressed in hsp70-expressing cells relative to that in the nontransfected control cells.	sodium arsenite	45-60	interleukin 6	Homo sapiens	0-3
8355691-5	1993	HSF activation in response to treatment with sodium arsenite or the proline analog azetidine was also depressed in hsp70-expressing cells relative to that in the nontransfected control cells.	sodium arsenite	45-60	heat shock protein family A (Hsp70) member 4	Homo sapiens	115-120
8431965-1	1993	Tissue specific changes in the cytochrome P-450 (P-450) monooxygenase system were observed following a single subcutaneous dose of sodium arsenite (75 mumol/kg), a known inducer of stress proteins.	sodium arsenite	131-146	cytochrome P450 3A14	Cavia porcellus	31-47
1607738-2	1992	In NRK cells, hsp70 was clearly induced by conditioning treatments (42 degrees C for 2 h, 45 degrees C for 15 min or 100 microM sodium arsenite for 1 h).	sodium arsenite	128-143	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	14-19
8433029-1	1993	HSP72 levels in the cellular and the nuclear (TX-insoluble) fraction before and after heating of heat- and sodium arsenite-induced thermotolerant and non-tolerant HeLa S3 cells have been investigated by 1D- and 2D-electrophoresis, followed by Western blotting and immunostaining, using a newly developed monoclonal antibody that specifically detects HSP72 (Heine et al.	sodium arsenite	107-122	heat shock protein family A (Hsp70) member 1A	Homo sapiens	0-5
1607378-7	1992	In cells exposed to either an amino acid analog or sodium arsenite, two potent inducers of the stress response, newly synthesized proteins bind to but are not released from hsp 70.	sodium arsenite	51-66	heat shock protein family A (Hsp70) member 4	Homo sapiens	173-179
1417842-0	1992	The adenovirus E3 region 14.7 kDa protein, heat and sodium arsenite inhibit the TNF-induced release of arachidonic acid.	sodium arsenite	52-67	tumor necrosis factor	Homo sapiens	80-83
1417842-1	1992	In this report we show that the adenovirus E3 region 14.7 kDa protein, heat and sodium arsenite, which have been defined previously as inhibitors of cytolysis, inhibit the tumor necrosis factor-alpha (TNF)-induced release of 3H-arachidonic acid from cycloheximide-sensitized C3HA fibroblasts.	sodium arsenite	80-95	tumor necrosis factor	Homo sapiens	172-199
1417842-1	1992	In this report we show that the adenovirus E3 region 14.7 kDa protein, heat and sodium arsenite, which have been defined previously as inhibitors of cytolysis, inhibit the tumor necrosis factor-alpha (TNF)-induced release of 3H-arachidonic acid from cycloheximide-sensitized C3HA fibroblasts.	sodium arsenite	80-95	tumor necrosis factor	Homo sapiens	201-204
1523582-3	1992	At embryotoxic exposures, sodium arsenite also induced the synthesis of three heat shock proteins (hsps), one of which is recognized by a monoclonal antibody specific for the heat-inducible hsp 72.	sodium arsenite	26-41	heat shock protein family A (Hsp70) member 1A	Rattus norvegicus	190-196
1523582-4	1992	In addition, sodium arsenite induced the accumulation of heat-inducible hsp 70 mRNA.	sodium arsenite	13-28	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	72-78
1597467-1	1992	The involvement of a vicinally spaced dithiol group in steroid binding to the glucocorticoid receptor has been deduced from experiments with the thiol-specific reagent methyl methanethiolsulfonate and the vicinal dithiol-specific reagent sodium arsenite.	sodium arsenite	238-253	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	78-101
1581359-2	1992	When the cells were treated with sodium arsenite or ethanol for 1 h at 37 degrees C, the activity of SAT increased time- and dose-dependently.	sodium arsenite	33-48	spermidine/spermine N1-acetyl transferase 1	Mus musculus	101-104
1569328-2	1992	The present study provided new evidence that HSP 72 was induced not only by heat and chemical agents, such as L-azetidine 2-carboxylic acid, and sodium arsenite, but also by ultraviolet (UV B and C).	sodium arsenite	145-160	heat shock protein family A (Hsp70) member 1A	Homo sapiens	45-51
1360409-2	1992	We investigated MDR1 gene expression in the well-differentiated hepatoma cell line HepG2 after exposure to several stresses and found that sodium arsenite treatment increased MDR1 gene expression 2.6-fold.	sodium arsenite	139-154	ATP binding cassette subfamily B member 1	Homo sapiens	16-20
1360409-2	1992	We investigated MDR1 gene expression in the well-differentiated hepatoma cell line HepG2 after exposure to several stresses and found that sodium arsenite treatment increased MDR1 gene expression 2.6-fold.	sodium arsenite	139-154	ATP binding cassette subfamily B member 1	Homo sapiens	175-179
1312348-12	1992	Interestingly, sodium arsenite produced both a greater induction of hsp 90 and hsp 70 synthesis and a greater fold enhancement of PR-mediated gene transcription than did heat shock.	sodium arsenite	15-30	heat shock protein 90 alpha family class A member 1	Homo sapiens	68-74
1312348-12	1992	Interestingly, sodium arsenite produced both a greater induction of hsp 90 and hsp 70 synthesis and a greater fold enhancement of PR-mediated gene transcription than did heat shock.	sodium arsenite	15-30	heat shock protein family A (Hsp70) member 4	Homo sapiens	79-85
2032293-0	1991	Sodium arsenite induces ATP depletion and mitochondrial damage in HeLa cells.	sodium arsenite	0-15	ATPase phospholipid transporting 8A2	Homo sapiens	24-27
1730584-6	1992	A similar shift to nuclear localization for unliganded glucocorticoid receptor is noted in L929 and WCL2 cells subjected to chemical shock (sodium arsenite).	sodium arsenite	140-155	nuclear receptor subfamily 3, group C, member 1	Mus musculus	55-78
1396606-2	1992	However, posttreatment of ultraviolet light (UV) irradiated cells with sodium arsenite synergistically enhances the mutation frequency on the hypoxanthine (guanine) phosphoribosyltransferase locus.	sodium arsenite	71-86	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	142-190
1396606-3	1992	To investigate the molecular mechanism of the comutagenic effects of sodium arsenite, we characterized the alterations of nucleotide sequences in 30 UV-induced and 39 sodium arsenite enhanced hprt mutants from Chinese hamster ovary K1 cells by direct sequencing of mRNA-PCR amplified cDNA.	sodium arsenite	69-84	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	192-196
1396606-3	1992	To investigate the molecular mechanism of the comutagenic effects of sodium arsenite, we characterized the alterations of nucleotide sequences in 30 UV-induced and 39 sodium arsenite enhanced hprt mutants from Chinese hamster ovary K1 cells by direct sequencing of mRNA-PCR amplified cDNA.	sodium arsenite	167-182	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	192-196
2023914-2	1991	Indeed, accumulation of alpha B-crystallin was detected immunologically in NIH 3T3 cells after incubation at elevated temperatures and after addition of Cd2+ or sodium arsenite to these cells.	sodium arsenite	161-176	crystallin, alpha B	Mus musculus	24-42
2032293-1	1991	Our present results show that treatment with sodium arsenite apparently decreases cellular ATP levels in a dose- and time-dependent manner in HeLa S-3 cells.	sodium arsenite	45-60	ATPase phospholipid transporting 8A2	Homo sapiens	91-94
2032293-2	1991	The reduction in ATP induced by sodium arsenite was possibly through mitochondrial damage, since treatment with sodium arsenite resulted in reduction of rhodamine 123 accumulation and disruption of the structure of the cristae in mitochondria.	sodium arsenite	32-47	ATPase phospholipid transporting 8A2	Homo sapiens	17-20
2032293-2	1991	The reduction in ATP induced by sodium arsenite was possibly through mitochondrial damage, since treatment with sodium arsenite resulted in reduction of rhodamine 123 accumulation and disruption of the structure of the cristae in mitochondria.	sodium arsenite	112-127	ATPase phospholipid transporting 8A2	Homo sapiens	17-20
2032293-4	1991	The levels of ATP depletion were correlated with the killing effects of sodium arsenite in HeLa S-3 cells.	sodium arsenite	72-87	ATPase phospholipid transporting 8A2	Homo sapiens	14-17
25199681-0	2015	Increased susceptibility of H-Ras(G12V)-transformed human urothelial cells to the genotoxic effects of sodium arsenite.	sodium arsenite	103-118	HRas proto-oncogene, GTPase	Homo sapiens	28-33
1687901-1	1991	In human chorionic villus tissue at the 10-17th week of a normal pregnancy, heat shock proteins (hsp70, hsp73, hsp85, and hsp105) were induced in vitro by a heat shock or by exposure to sodium arsenite or cadmium chloride.	sodium arsenite	186-201	heat shock protein family A (Hsp70) member 4	Homo sapiens	97-102
1687901-1	1991	In human chorionic villus tissue at the 10-17th week of a normal pregnancy, heat shock proteins (hsp70, hsp73, hsp85, and hsp105) were induced in vitro by a heat shock or by exposure to sodium arsenite or cadmium chloride.	sodium arsenite	186-201	heat shock protein family A (Hsp70) member 8	Homo sapiens	104-109
1687901-1	1991	In human chorionic villus tissue at the 10-17th week of a normal pregnancy, heat shock proteins (hsp70, hsp73, hsp85, and hsp105) were induced in vitro by a heat shock or by exposure to sodium arsenite or cadmium chloride.	sodium arsenite	186-201	heat shock protein family H (Hsp110) member 1	Homo sapiens	122-128
1687901-2	1991	In dispersed cells of the whole mouse embryo on the 11th day of development, heat shock proteins (hsp73 and hsp105) were induced by a heat shock or by exposure to sodium arsenite, but not by exposure to cadmium chloride.	sodium arsenite	163-178	heat shock protein 8	Mus musculus	98-103
1687901-2	1991	In dispersed cells of the whole mouse embryo on the 11th day of development, heat shock proteins (hsp73 and hsp105) were induced by a heat shock or by exposure to sodium arsenite, but not by exposure to cadmium chloride.	sodium arsenite	163-178	heat shock 105kDa/110kDa protein 1	Mus musculus	108-114
2266108-13	1990	Induction of p56 also occurs in IM-9 cells subjected to chemical stress (sodium arsenite).	sodium arsenite	73-88	interferon induced protein with tetratricopeptide repeats 1	Homo sapiens	13-16
2111988-3	1990	Sodium arsenite induced both hsp 70 and c-fos transcripts.	sodium arsenite	0-15	heat shock protein 1B	Mus musculus	29-35
2111988-3	1990	Sodium arsenite induced both hsp 70 and c-fos transcripts.	sodium arsenite	0-15	FBJ osteosarcoma oncogene	Mus musculus	40-45
2340977-7	1990	Sodium arsenite induced the highest levels of synthesis of these two proteins, approximately 10-fold and 3-fold increases in hsp-70 and hsp-90, respectively.	sodium arsenite	0-15	heat shock protein family A (Hsp70) member 4	Homo sapiens	125-131
2340977-7	1990	Sodium arsenite induced the highest levels of synthesis of these two proteins, approximately 10-fold and 3-fold increases in hsp-70 and hsp-90, respectively.	sodium arsenite	0-15	heat shock protein 90 alpha family class A member 1	Homo sapiens	136-142
2005667-2	1991	Female balb/c mice injected with arsanilic acid conjugated to a carrier protein (ovalbumin) were shown to produce antibodies (arsenic reactive serum, ARS) reactive with arsanilic acid and sodium arsenite.	sodium arsenite	188-203	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	81-90
2005667-5	1991	Following multiple injections of 100 micrograms of arsanilic acid--ovalbumin compound, mortality on injection with sodium arsenite 0.87 mg/kg i.p.	sodium arsenite	115-130	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	67-76
1967174-6	1990	Exposure of HTB-46 cells to heat shock, sodium arsenite, or cadmium chloride led to a 7- to 8-fold increase in MDR1 mRNA levels.	sodium arsenite	40-55	ATP binding cassette subfamily B member 1	Homo sapiens	111-115
1967174-8	1990	The levels of the multidrug transporter, P-glycoprotein, as measured by immunoprecipitation, were also increased after heat shock and sodium arsenite treatment.	sodium arsenite	134-149	ATP binding cassette subfamily B member 1	Homo sapiens	41-55
2256819-6	1990	These studies showed that (a) sodium arsenite and AZC enhanced the cellular levels of hsp47 in both types of fibroblast, (b) the colligin/hsp47 levels expressed were associated with elevated levels of protein and collagen production and (c) the presence of colligin/hsp47 was decreased under conditions of serum deprivation.	sodium arsenite	30-45	serpin family H member 1	Homo sapiens	86-91
2256819-6	1990	These studies showed that (a) sodium arsenite and AZC enhanced the cellular levels of hsp47 in both types of fibroblast, (b) the colligin/hsp47 levels expressed were associated with elevated levels of protein and collagen production and (c) the presence of colligin/hsp47 was decreased under conditions of serum deprivation.	sodium arsenite	30-45	serpin family H member 1	Homo sapiens	138-143
2256819-6	1990	These studies showed that (a) sodium arsenite and AZC enhanced the cellular levels of hsp47 in both types of fibroblast, (b) the colligin/hsp47 levels expressed were associated with elevated levels of protein and collagen production and (c) the presence of colligin/hsp47 was decreased under conditions of serum deprivation.	sodium arsenite	30-45	serpin family H member 1	Homo sapiens	138-143
33774797-12	2021	CS-EA fractioned treated group overturned the sodium arsenite driven higher expression of pro-inflammatory cytokines and proapoptotic markers along with a low level of anti apoptotic Bcl-2 expression and comparatively lower NF-kappaB signalling in the uterus via regulating IKK beta kinase mostly by EGCG of CS-EA fraction.	sodium arsenite	46-61	component of inhibitor of nuclear factor kappa B kinase complex	Rattus norvegicus	274-282
34920032-4	2022	Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2.	sodium arsenite	23-38	NLR family, pyrin domain containing 3	Rattus norvegicus	58-102
34920032-4	2022	Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2.	sodium arsenite	23-38	NLR family, pyrin domain containing 3	Rattus norvegicus	104-109
34920032-4	2022	Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2.	sodium arsenite	23-38	gasdermin D	Rattus norvegicus	135-140
34920032-4	2022	Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2.	sodium arsenite	40-46	NLR family, pyrin domain containing 3	Rattus norvegicus	58-102
34920032-4	2022	Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2.	sodium arsenite	40-46	NLR family, pyrin domain containing 3	Rattus norvegicus	104-109
34920032-4	2022	Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2.	sodium arsenite	40-46	gasdermin D	Rattus norvegicus	135-140
34920032-4	2022	Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2.	sodium arsenite	40-46	gasdermin D	Rattus norvegicus	194-199
34920032-4	2022	Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2.	sodium arsenite	257-263	gasdermin D	Rattus norvegicus	194-199
34920032-7	2022	We observed that NaAsO2 reduced the K48- and K63-linked ubiquitination of GSDMD, thereby inhibiting its degradation through the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway (ALP), causing GSDMD to accumulate and lyse into GSDMD-N, which promoted pyroptosis.	sodium arsenite	17-23	gasdermin D	Rattus norvegicus	74-79
34920032-7	2022	We observed that NaAsO2 reduced the K48- and K63-linked ubiquitination of GSDMD, thereby inhibiting its degradation through the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway (ALP), causing GSDMD to accumulate and lyse into GSDMD-N, which promoted pyroptosis.	sodium arsenite	17-23	gasdermin D	Rattus norvegicus	212-217
34920032-7	2022	We observed that NaAsO2 reduced the K48- and K63-linked ubiquitination of GSDMD, thereby inhibiting its degradation through the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway (ALP), causing GSDMD to accumulate and lyse into GSDMD-N, which promoted pyroptosis.	sodium arsenite	17-23	gasdermin D	Rattus norvegicus	246-251
34920032-9	2022	Moreover, NaAsO2 reduced GSDMD ubiquitination and decreased its intracellular degradation, aggravating pyroptosis and hepatic IR.	sodium arsenite	10-16	gasdermin D	Rattus norvegicus	25-30
34897760-3	2022	Results revealed protective effect of both intermittent and continuous kisspeptin doses on reproductive organs against sodium arsenite-induced toxicity.	sodium arsenite	119-134	KiSS-1 metastasis-suppressor	Mus musculus	71-81
34798143-3	2022	The purpose of this work was to determine whether inorganic arsenic (NaAsO2) and its metabolites influenced the expression of PUMA in vivo and vitro, followed by investigating the mechanisms.	sodium arsenite	69-75	BCL2 binding component 3	Homo sapiens	126-130
34798143-7	2022	According to the results of qRT-PCR and western blotting, NaAsO2 caused the overexpression of PUMA, not its metabolites.	sodium arsenite	58-64	BCL2 binding component 3	Homo sapiens	94-98
34798143-8	2022	Furthermore, NaAsO2 induced phosphorylation of p53 at Ser315, 376, 392, and Thr55, and acetylation of p53 at K370, 382 with a dose-response relationship, suggesting the contribution of PUMA up-regulation to p53 phosphorylation and acetylation.	sodium arsenite	13-19	tumor protein p53	Homo sapiens	47-50
34798143-8	2022	Furthermore, NaAsO2 induced phosphorylation of p53 at Ser315, 376, 392, and Thr55, and acetylation of p53 at K370, 382 with a dose-response relationship, suggesting the contribution of PUMA up-regulation to p53 phosphorylation and acetylation.	sodium arsenite	13-19	tumor protein p53	Homo sapiens	102-105
34798143-8	2022	Furthermore, NaAsO2 induced phosphorylation of p53 at Ser315, 376, 392, and Thr55, and acetylation of p53 at K370, 382 with a dose-response relationship, suggesting the contribution of PUMA up-regulation to p53 phosphorylation and acetylation.	sodium arsenite	13-19	BCL2 binding component 3	Homo sapiens	185-189
34798143-8	2022	Furthermore, NaAsO2 induced phosphorylation of p53 at Ser315, 376, 392, and Thr55, and acetylation of p53 at K370, 382 with a dose-response relationship, suggesting the contribution of PUMA up-regulation to p53 phosphorylation and acetylation.	sodium arsenite	13-19	tumor protein p53	Homo sapiens	207-210
34798143-10	2022	The co-immunoprecipitation assay showed that the interaction between PUMA and Bcl-X enhanced in intensity responding to NaAsO2 exposure, disrupting the complexes of Bcl-X with other pro-survival Bcl-2-related proteins.	sodium arsenite	120-126	BCL2 binding component 3	Homo sapiens	69-73
34798143-10	2022	The co-immunoprecipitation assay showed that the interaction between PUMA and Bcl-X enhanced in intensity responding to NaAsO2 exposure, disrupting the complexes of Bcl-X with other pro-survival Bcl-2-related proteins.	sodium arsenite	120-126	BCL2 like 1	Homo sapiens	78-83
34798143-10	2022	The co-immunoprecipitation assay showed that the interaction between PUMA and Bcl-X enhanced in intensity responding to NaAsO2 exposure, disrupting the complexes of Bcl-X with other pro-survival Bcl-2-related proteins.	sodium arsenite	120-126	BCL2 like 1	Homo sapiens	165-170
34798143-11	2022	To our knowledge, we first reported that NaAsO2 activated phosphorylation of p53 at Ser315, 376, and Thr55, as well as acetylation of p53 at K370.	sodium arsenite	41-47	tumor protein p53	Homo sapiens	77-80
34798143-11	2022	To our knowledge, we first reported that NaAsO2 activated phosphorylation of p53 at Ser315, 376, and Thr55, as well as acetylation of p53 at K370.	sodium arsenite	41-47	tumor protein p53	Homo sapiens	134-137
34943121-5	2021	Our work indicates that the depletion of CERKL increases the vulnerability of RPE mitochondria, which show a shorter size and altered shape, particularly upon sodium arsenite treatment.	sodium arsenite	159-174	ceramide kinase like	Homo sapiens	41-46
34774526-6	2021	We further show that nsp1 interacts with Ras-GTPase-activating protein SH3-domain-binding protein 1 (G3BP1) and colocalizes with G3BP1 in SGs under sodium arsenite-induced stress.	sodium arsenite	148-163	SH2 domain containing 3A	Homo sapiens	21-25
34217924-4	2021	One strain encoded as PMS5 with the highest resistance to 140-mM sodium arsenite and 600-mM sodium arsenate in tryptic soy broth was selected for further investigations.	sodium arsenite	65-80	PMS1 homolog 2, mismatch repair system component pseudogene 3	Homo sapiens	22-26
34429248-4	2021	TDP-43 transgenic human iPS cells were constructed, differentiated into motor neurons, and then treated with MG-132 and sodium arsenite (stressors) to induce nuclear to cytoplasmic localization of TDP-43.	sodium arsenite	120-135	TAR DNA binding protein	Homo sapiens	0-6
34429248-4	2021	TDP-43 transgenic human iPS cells were constructed, differentiated into motor neurons, and then treated with MG-132 and sodium arsenite (stressors) to induce nuclear to cytoplasmic localization of TDP-43.	sodium arsenite	120-135	TAR DNA binding protein	Homo sapiens	197-203
34926170-0	2021	Co-exposure of sodium arsenite and uranyl acetate differentially alters gene expression in CD3/CD28 activated CD4+ T-cells.	sodium arsenite	15-30	CD28 molecule	Homo sapiens	95-99
34926170-0	2021	Co-exposure of sodium arsenite and uranyl acetate differentially alters gene expression in CD3/CD28 activated CD4+ T-cells.	sodium arsenite	15-30	CD4 molecule	Homo sapiens	110-113
34771016-8	2021	NaAsO2 increased the levels of TNF-alpha, 8-hydroxy-2-deoxy guanosine (8OHdG), malondialdehyde (MDA), reactive oxygen species (ROS), and high mobility group box 1 (HMGB1), increased the expression of TNF receptor type 1-associated death domain (TRADD) mRNA and telomerase reverse transcriptase, and decreased the expression of Klotho (KL) mRNA in both plasma and tissues.	sodium arsenite	0-6	tumor necrosis factor	Rattus norvegicus	31-40
34899304-2	2021	The results revealed that DIP pretreatment inhibited NaAsO2 induced L-02 cells apoptosis by increasing anti-apoptotic Bcl-2 expression and decreasing pro-apoptotic Bax expression.	sodium arsenite	53-59	BCL2 apoptosis regulator	Homo sapiens	118-123
34899304-2	2021	The results revealed that DIP pretreatment inhibited NaAsO2 induced L-02 cells apoptosis by increasing anti-apoptotic Bcl-2 expression and decreasing pro-apoptotic Bax expression.	sodium arsenite	53-59	BCL2 associated X, apoptosis regulator	Homo sapiens	164-167
34771016-8	2021	NaAsO2 increased the levels of TNF-alpha, 8-hydroxy-2-deoxy guanosine (8OHdG), malondialdehyde (MDA), reactive oxygen species (ROS), and high mobility group box 1 (HMGB1), increased the expression of TNF receptor type 1-associated death domain (TRADD) mRNA and telomerase reverse transcriptase, and decreased the expression of Klotho (KL) mRNA in both plasma and tissues.	sodium arsenite	0-6	high mobility group box 1	Rattus norvegicus	137-162
34771016-8	2021	NaAsO2 increased the levels of TNF-alpha, 8-hydroxy-2-deoxy guanosine (8OHdG), malondialdehyde (MDA), reactive oxygen species (ROS), and high mobility group box 1 (HMGB1), increased the expression of TNF receptor type 1-associated death domain (TRADD) mRNA and telomerase reverse transcriptase, and decreased the expression of Klotho (KL) mRNA in both plasma and tissues.	sodium arsenite	0-6	high mobility group box 1	Rattus norvegicus	164-169
34771016-8	2021	NaAsO2 increased the levels of TNF-alpha, 8-hydroxy-2-deoxy guanosine (8OHdG), malondialdehyde (MDA), reactive oxygen species (ROS), and high mobility group box 1 (HMGB1), increased the expression of TNF receptor type 1-associated death domain (TRADD) mRNA and telomerase reverse transcriptase, and decreased the expression of Klotho (KL) mRNA in both plasma and tissues.	sodium arsenite	0-6	Klotho	Rattus norvegicus	327-333
34771016-8	2021	NaAsO2 increased the levels of TNF-alpha, 8-hydroxy-2-deoxy guanosine (8OHdG), malondialdehyde (MDA), reactive oxygen species (ROS), and high mobility group box 1 (HMGB1), increased the expression of TNF receptor type 1-associated death domain (TRADD) mRNA and telomerase reverse transcriptase, and decreased the expression of Klotho (KL) mRNA in both plasma and tissues.	sodium arsenite	0-6	Klotho	Rattus norvegicus	335-337
34616479-6	2021	Quantification of sodium arsenite-induced reactive oxygen species (ROS) was measured in TDP-43 stress granular cells using 2,7-diacetyl dichlorofluorescein diacetate.	sodium arsenite	18-33	TAR DNA binding protein	Homo sapiens	88-94
34364127-4	2021	We found that NaAsO2 caused hepatic IR, activated NLRP3 inflammasome, and inhibited glycolysis pathway in vivo.	sodium arsenite	14-20	NLR family pyrin domain containing 3	Homo sapiens	50-55
34364127-10	2021	In summary, after treatment with NaAsO2, NLRP3 inflammasome blocked the glycolytic pathway via binding to PKLR, which in turn caused hepatic IR.	sodium arsenite	33-39	NLR family pyrin domain containing 3	Homo sapiens	41-46
34364127-10	2021	In summary, after treatment with NaAsO2, NLRP3 inflammasome blocked the glycolytic pathway via binding to PKLR, which in turn caused hepatic IR.	sodium arsenite	33-39	pyruvate kinase L/R	Homo sapiens	106-110
34303791-0	2021	Human prostate epithelial cells and prostate-derived stem cells malignantly transformed in vitro with sodium arsenite show impaired Toll like receptor -3 (TLR3)-associated anti-tumor pathway.	sodium arsenite	102-117	toll like receptor 3	Homo sapiens	155-159
35381244-6	2022	Further, low dose of NaAsO2 enhanced the AhR signaling pathway and autophagy-related mRNA/protein expressions induced by DON.	sodium arsenite	21-27	aryl hydrocarbon receptor	Sus scrofa	41-44
34221922-6	2021	The effects of NaAsO2 on the methylation of H3 in the promoter regions of 78 kDa glucose-regulated protein, activating transcription factor 4 and C/EBP-homologous protein were evaluated by chromatin immunoprecipitation assay.	sodium arsenite	15-21	heat shock protein family A (Hsp70) member 5	Homo sapiens	74-106
34221922-6	2021	The effects of NaAsO2 on the methylation of H3 in the promoter regions of 78 kDa glucose-regulated protein, activating transcription factor 4 and C/EBP-homologous protein were evaluated by chromatin immunoprecipitation assay.	sodium arsenite	15-21	activating transcription factor 4	Homo sapiens	108-141
34221922-10	2021	NaAsO2 induces apoptosis in LO2 cells by activating the ERS-mediated apoptotic signaling pathway, at least partially by enhancing the methylation of H3 on the promoter regions of ERS-associated genes, including GRP78 and CHOP.	sodium arsenite	0-6	heat shock protein family A (Hsp70) member 5	Homo sapiens	211-216
34221922-10	2021	NaAsO2 induces apoptosis in LO2 cells by activating the ERS-mediated apoptotic signaling pathway, at least partially by enhancing the methylation of H3 on the promoter regions of ERS-associated genes, including GRP78 and CHOP.	sodium arsenite	0-6	DNA damage inducible transcript 3	Homo sapiens	221-225
34348425-7	2021	In addition, SA inhibited catalase and glutathione-S-transferase (GST) activities, and depleted total thiol and glutathione (GSH) contents.	sodium arsenite	13-15	Glutathione S transferase S1	Drosophila melanogaster	39-64
34348425-7	2021	In addition, SA inhibited catalase and glutathione-S-transferase (GST) activities, and depleted total thiol and glutathione (GSH) contents.	sodium arsenite	13-15	Glutathione S transferase S1	Drosophila melanogaster	66-69
34348425-8	2021	Moreover, acetylcholinesterase activity significantly increased in flies treated with SA when compared with control.	sodium arsenite	86-88	Acetylcholine esterase	Drosophila melanogaster	10-30
35381244-5	2022	The results showed that low dose of NaAsO2 exacerbated DON-induced intestinal impairment by increasing intestinal permeability and decreasing the abundance of tight junction proteins (ZO-1, Occludin, Claudin-1).	sodium arsenite	36-42	zonula occludens 1	Sus scrofa	184-188
35381244-5	2022	The results showed that low dose of NaAsO2 exacerbated DON-induced intestinal impairment by increasing intestinal permeability and decreasing the abundance of tight junction proteins (ZO-1, Occludin, Claudin-1).	sodium arsenite	36-42	occludin	Sus scrofa	190-198
35381244-7	2022	Interestingly, FICZ, an AhR activator, instead of CH223191, an AhR inhibitor, could alleviate toxicity of the low dose of NaAsO2 in the mice and IPEC-J2 cells.	sodium arsenite	122-128	aryl-hydrocarbon receptor	Mus musculus	24-27
35381244-5	2022	The results showed that low dose of NaAsO2 exacerbated DON-induced intestinal impairment by increasing intestinal permeability and decreasing the abundance of tight junction proteins (ZO-1, Occludin, Claudin-1).	sodium arsenite	36-42	claudin 1	Sus scrofa	200-209
35381244-7	2022	Interestingly, FICZ, an AhR activator, instead of CH223191, an AhR inhibitor, could alleviate toxicity of the low dose of NaAsO2 in the mice and IPEC-J2 cells.	sodium arsenite	122-128	aryl-hydrocarbon receptor	Mus musculus	63-66
35381244-11	2022	Hence, AhR and autophagy might be novel therapeutic targets to prevent or alleviate NaAsO2 combined with DON-induced intestinal barrier impairment.	sodium arsenite	84-90	aryl hydrocarbon receptor	Sus scrofa	7-10
35441311-6	2022	Using RNAi and RT-PCR, it has been further confirmed that OV modulates transcription factor SKN-1, the nuclear factor erythroid 2-related factor 2 (Nrf2) homologous, in C. elegans, enhancing the resistance of C. elegans against sodium arsenite stress.	sodium arsenite	228-243	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	92-97
35351881-7	2022	Western blotting showed increased levels of cleaved PARP-1 and cleaved caspase-3 in SA-treated mice consistent with SA-induced apoptosis.	sodium arsenite	84-86	poly (ADP-ribose) polymerase family, member 1	Mus musculus	52-58
35624898-5	2022	This review focuses on the mechanisms regulating the mitochondrial formation of ROS after exposure to low concentrations of a specific arsenic compound, NaAsO2, and their crosstalk with the nuclear factor (erythroid-2 related) factor 2 antioxidant signaling and the endoplasmic reticulum stress response.	sodium arsenite	153-159	NFE2 like bZIP transcription factor 2	Homo sapiens	190-235
35563241-11	2022	The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2).	sodium arsenite	102-117	junctional adhesion molecule 2	Homo sapiens	260-264
35563241-11	2022	The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2).	sodium arsenite	102-117	integrin subunit beta 3	Homo sapiens	266-271
35563241-11	2022	The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2).	sodium arsenite	102-117	notch receptor 4	Homo sapiens	276-282
35563241-11	2022	The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2).	sodium arsenite	102-117	claudin 2	Homo sapiens	311-316
35563241-11	2022	The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2).	sodium arsenite	102-117	claudin 3	Homo sapiens	318-323
35563241-11	2022	The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2).	sodium arsenite	102-117	gap junction protein beta 1	Homo sapiens	325-329
35563241-11	2022	The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2).	sodium arsenite	102-117	gap junction protein beta 2	Homo sapiens	335-339
35259467-0	2022	Sodium arsenite accelerates D-galactose-induced aging in the testis of the rat: Evidence for mitochondrial oxidative damage, NF-kB, JNK, and apoptosis pathways.	sodium arsenite	0-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	125-130
35259467-0	2022	Sodium arsenite accelerates D-galactose-induced aging in the testis of the rat: Evidence for mitochondrial oxidative damage, NF-kB, JNK, and apoptosis pathways.	sodium arsenite	0-15	mitogen-activated protein kinase 8	Rattus norvegicus	132-135
35351881-7	2022	Western blotting showed increased levels of cleaved PARP-1 and cleaved caspase-3 in SA-treated mice consistent with SA-induced apoptosis.	sodium arsenite	84-86	caspase 3	Mus musculus	71-80
35351881-7	2022	Western blotting showed increased levels of cleaved PARP-1 and cleaved caspase-3 in SA-treated mice consistent with SA-induced apoptosis.	sodium arsenite	116-118	poly (ADP-ribose) polymerase family, member 1	Mus musculus	52-58
35351881-7	2022	Western blotting showed increased levels of cleaved PARP-1 and cleaved caspase-3 in SA-treated mice consistent with SA-induced apoptosis.	sodium arsenite	116-118	caspase 3	Mus musculus	71-80
35313999-4	2022	RESULTS: SA treatment showed hepatic pathological injury and the elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) in serum, and induced the increases of malondialdehyde (MDA), Th17 cells, OX40 or IL-17A in liver tissues, which were consistently ameliorated by Lentinan intervention.	sodium arsenite	9-11	glutamic pyruvic transaminase, soluble	Mus musculus	79-103
35313999-4	2022	RESULTS: SA treatment showed hepatic pathological injury and the elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) in serum, and induced the increases of malondialdehyde (MDA), Th17 cells, OX40 or IL-17A in liver tissues, which were consistently ameliorated by Lentinan intervention.	sodium arsenite	9-11	glutamic pyruvic transaminase, soluble	Mus musculus	105-108
35313999-4	2022	RESULTS: SA treatment showed hepatic pathological injury and the elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) in serum, and induced the increases of malondialdehyde (MDA), Th17 cells, OX40 or IL-17A in liver tissues, which were consistently ameliorated by Lentinan intervention.	sodium arsenite	9-11	tumor necrosis factor receptor superfamily, member 4	Mus musculus	220-224
35313999-4	2022	RESULTS: SA treatment showed hepatic pathological injury and the elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) in serum, and induced the increases of malondialdehyde (MDA), Th17 cells, OX40 or IL-17A in liver tissues, which were consistently ameliorated by Lentinan intervention.	sodium arsenite	9-11	interleukin 17A	Mus musculus	228-234
35313999-7	2022	CONCLUSION: Lentinan antagonizes SA-induced hepatotoxicity in mice, may be involved in the downregulations of pro-inflammatory OX40 or IL-17A and the activation of anti-oxidative Nrf2, NQO1 signals.	sodium arsenite	33-35	tumor necrosis factor receptor superfamily, member 4	Mus musculus	127-131
35313999-7	2022	CONCLUSION: Lentinan antagonizes SA-induced hepatotoxicity in mice, may be involved in the downregulations of pro-inflammatory OX40 or IL-17A and the activation of anti-oxidative Nrf2, NQO1 signals.	sodium arsenite	33-35	interleukin 17A	Mus musculus	135-141
35320977-0	2022	The Molecular Mechanism of Hepatic Lipid Metabolism Disorder Caused by NaAsO2 through Regulating the ERK/PPAR Signaling Pathway.	sodium arsenite	71-77	Eph receptor B1	Rattus norvegicus	101-104
35298964-9	2022	RESULTS: Compared with the control group, with the gradual increasing dose of NaAsO2, cell viability was considerable reduced, and increased rate of apoptosis, intracellular GSH level was decreased significantly, ROS was increased, mitochondrial structure was damaged, mitochondrial membrane potential DeltaPsim and Bcl2/BAX lowered, the expression of Caspase3 and cleaved-caspase3 were significantly increased, resulting in mitochondrial apoptosis.	sodium arsenite	78-84	BCL2 apoptosis regulator	Homo sapiens	316-320
35298964-9	2022	RESULTS: Compared with the control group, with the gradual increasing dose of NaAsO2, cell viability was considerable reduced, and increased rate of apoptosis, intracellular GSH level was decreased significantly, ROS was increased, mitochondrial structure was damaged, mitochondrial membrane potential DeltaPsim and Bcl2/BAX lowered, the expression of Caspase3 and cleaved-caspase3 were significantly increased, resulting in mitochondrial apoptosis.	sodium arsenite	78-84	BCL2 associated X, apoptosis regulator	Homo sapiens	321-324
35298964-9	2022	RESULTS: Compared with the control group, with the gradual increasing dose of NaAsO2, cell viability was considerable reduced, and increased rate of apoptosis, intracellular GSH level was decreased significantly, ROS was increased, mitochondrial structure was damaged, mitochondrial membrane potential DeltaPsim and Bcl2/BAX lowered, the expression of Caspase3 and cleaved-caspase3 were significantly increased, resulting in mitochondrial apoptosis.	sodium arsenite	78-84	caspase 3	Homo sapiens	352-360
35298964-10	2022	When Hela cells were treated with 15, 20, and 25 mumol/L NaAsO2, the mRNA and protein levels of GCLC and GCLM were reduced, the expression of p65 in the nucleus was increased, the expression of p-p65/p65, p-IkappaBalpha/IkappaBalpha and miR-21 were significantly increased.	sodium arsenite	57-63	glutamate-cysteine ligase catalytic subunit	Homo sapiens	96-100
35298964-10	2022	When Hela cells were treated with 15, 20, and 25 mumol/L NaAsO2, the mRNA and protein levels of GCLC and GCLM were reduced, the expression of p65 in the nucleus was increased, the expression of p-p65/p65, p-IkappaBalpha/IkappaBalpha and miR-21 were significantly increased.	sodium arsenite	57-63	glutamate-cysteine ligase modifier subunit	Homo sapiens	105-109
35298964-10	2022	When Hela cells were treated with 15, 20, and 25 mumol/L NaAsO2, the mRNA and protein levels of GCLC and GCLM were reduced, the expression of p65 in the nucleus was increased, the expression of p-p65/p65, p-IkappaBalpha/IkappaBalpha and miR-21 were significantly increased.	sodium arsenite	57-63	RELA proto-oncogene, NF-kB subunit	Homo sapiens	142-145
35298964-10	2022	When Hela cells were treated with 15, 20, and 25 mumol/L NaAsO2, the mRNA and protein levels of GCLC and GCLM were reduced, the expression of p65 in the nucleus was increased, the expression of p-p65/p65, p-IkappaBalpha/IkappaBalpha and miR-21 were significantly increased.	sodium arsenite	57-63	RELA proto-oncogene, NF-kB subunit	Homo sapiens	194-219
35298964-10	2022	When Hela cells were treated with 15, 20, and 25 mumol/L NaAsO2, the mRNA and protein levels of GCLC and GCLM were reduced, the expression of p65 in the nucleus was increased, the expression of p-p65/p65, p-IkappaBalpha/IkappaBalpha and miR-21 were significantly increased.	sodium arsenite	57-63	NFKB inhibitor alpha	Homo sapiens	220-232
35298964-10	2022	When Hela cells were treated with 15, 20, and 25 mumol/L NaAsO2, the mRNA and protein levels of GCLC and GCLM were reduced, the expression of p65 in the nucleus was increased, the expression of p-p65/p65, p-IkappaBalpha/IkappaBalpha and miR-21 were significantly increased.	sodium arsenite	57-63	microRNA 21	Homo sapiens	237-243
35298964-11	2022	When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased.	sodium arsenite	44-50	glutamate-cysteine ligase catalytic subunit	Homo sapiens	54-58
35298964-11	2022	When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased.	sodium arsenite	44-50	BCL2 apoptosis regulator	Homo sapiens	117-122
35298964-11	2022	When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased.	sodium arsenite	44-50	BCL2 associated X, apoptosis regulator	Homo sapiens	123-126
35298964-11	2022	When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased.	sodium arsenite	44-50	caspase 3	Homo sapiens	128-136
35298964-11	2022	When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased.	sodium arsenite	74-80	glutamate-cysteine ligase catalytic subunit	Homo sapiens	54-58
35298964-11	2022	When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased.	sodium arsenite	74-80	BCL2 apoptosis regulator	Homo sapiens	117-122
35298964-11	2022	When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased.	sodium arsenite	74-80	BCL2 associated X, apoptosis regulator	Homo sapiens	123-126
35298964-11	2022	When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased.	sodium arsenite	74-80	caspase 3	Homo sapiens	128-136
35298964-12	2022	When BAY 11-7082 combined with NaAsO2 co-treated, compared with the NaAsO2 group, the protein and mRNA expression of GCLC was increased, NaAsO2-increased expression level of miR-21 was suppressed, and the DeltaPsim and cell viability were higher.	sodium arsenite	31-37	glutamate-cysteine ligase catalytic subunit	Homo sapiens	117-121
35298964-12	2022	When BAY 11-7082 combined with NaAsO2 co-treated, compared with the NaAsO2 group, the protein and mRNA expression of GCLC was increased, NaAsO2-increased expression level of miR-21 was suppressed, and the DeltaPsim and cell viability were higher.	sodium arsenite	31-37	microRNA 21	Homo sapiens	174-180
35298964-12	2022	When BAY 11-7082 combined with NaAsO2 co-treated, compared with the NaAsO2 group, the protein and mRNA expression of GCLC was increased, NaAsO2-increased expression level of miR-21 was suppressed, and the DeltaPsim and cell viability were higher.	sodium arsenite	68-74	glutamate-cysteine ligase catalytic subunit	Homo sapiens	117-121
35298964-12	2022	When BAY 11-7082 combined with NaAsO2 co-treated, compared with the NaAsO2 group, the protein and mRNA expression of GCLC was increased, NaAsO2-increased expression level of miR-21 was suppressed, and the DeltaPsim and cell viability were higher.	sodium arsenite	137-143	microRNA 21	Homo sapiens	174-180
35298964-13	2022	In addition, compared with the combination of NaAsO2 and miR-21NC, the protein expression of GCLC was increased, the DeltaPsim and cell viability reduction were alleviated by miR-21 Inhibitor combined with NaAsO2.	sodium arsenite	46-52	glutamate-cysteine ligase catalytic subunit	Homo sapiens	93-97
35298964-13	2022	In addition, compared with the combination of NaAsO2 and miR-21NC, the protein expression of GCLC was increased, the DeltaPsim and cell viability reduction were alleviated by miR-21 Inhibitor combined with NaAsO2.	sodium arsenite	46-52	microRNA 21	Homo sapiens	175-181
35298964-13	2022	In addition, compared with the combination of NaAsO2 and miR-21NC, the protein expression of GCLC was increased, the DeltaPsim and cell viability reduction were alleviated by miR-21 Inhibitor combined with NaAsO2.	sodium arsenite	206-212	microRNA 21	Homo sapiens	57-63
35298964-13	2022	In addition, compared with the combination of NaAsO2 and miR-21NC, the protein expression of GCLC was increased, the DeltaPsim and cell viability reduction were alleviated by miR-21 Inhibitor combined with NaAsO2.	sodium arsenite	206-212	glutamate-cysteine ligase catalytic subunit	Homo sapiens	93-97
35298964-0	2022	NaAsO2 decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-kappaB/miR-21 signaling pathway.	sodium arsenite	0-6	glutamate-cysteine ligase catalytic subunit	Homo sapiens	45-49
35298964-0	2022	NaAsO2 decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-kappaB/miR-21 signaling pathway.	sodium arsenite	0-6	nuclear factor kappa B subunit 1	Homo sapiens	144-153
35298964-0	2022	NaAsO2 decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-kappaB/miR-21 signaling pathway.	sodium arsenite	0-6	microRNA 21	Homo sapiens	154-160
35298964-5	2022	However, the role of miR-21 in the mitochondrial pathway of cervical cancer cells induced by NaAsO2 through NF-kappaB/GCLC and GSH synthesis regulated oxidative stress is rarely reported.	sodium arsenite	93-99	microRNA 21	Homo sapiens	21-27
35298964-5	2022	However, the role of miR-21 in the mitochondrial pathway of cervical cancer cells induced by NaAsO2 through NF-kappaB/GCLC and GSH synthesis regulated oxidative stress is rarely reported.	sodium arsenite	93-99	nuclear factor kappa B subunit 1	Homo sapiens	108-117
35298964-5	2022	However, the role of miR-21 in the mitochondrial pathway of cervical cancer cells induced by NaAsO2 through NF-kappaB/GCLC and GSH synthesis regulated oxidative stress is rarely reported.	sodium arsenite	93-99	glutamate-cysteine ligase catalytic subunit	Homo sapiens	118-122
35298964-6	2022	Therefore, the purpose of this study was to investigate whether NaAsO2 might induce mitochondrial damage and apoptosis of cervical cancer cells through NF-kappaB/ miR-21 /GCLC induced oxidative stress, and play the anti-tumor role of arsenic as a potential drug for the treatment of cervical cancer.	sodium arsenite	64-70	nuclear factor kappa B subunit 1	Homo sapiens	152-161
35298964-6	2022	Therefore, the purpose of this study was to investigate whether NaAsO2 might induce mitochondrial damage and apoptosis of cervical cancer cells through NF-kappaB/ miR-21 /GCLC induced oxidative stress, and play the anti-tumor role of arsenic as a potential drug for the treatment of cervical cancer.	sodium arsenite	64-70	microRNA 21	Homo sapiens	163-169
35298964-6	2022	Therefore, the purpose of this study was to investigate whether NaAsO2 might induce mitochondrial damage and apoptosis of cervical cancer cells through NF-kappaB/ miR-21 /GCLC induced oxidative stress, and play the anti-tumor role of arsenic as a potential drug for the treatment of cervical cancer.	sodium arsenite	64-70	glutamate-cysteine ligase catalytic subunit	Homo sapiens	171-175
35320977-0	2022	The Molecular Mechanism of Hepatic Lipid Metabolism Disorder Caused by NaAsO2 through Regulating the ERK/PPAR Signaling Pathway.	sodium arsenite	71-77	peroxisome proliferator activated receptor alpha	Rattus norvegicus	105-109
35237411-4	2022	However, the mechanism underlying the involvement of PINK1/Parkin in NaAsO2-induced mitophagy is unclear.	sodium arsenite	69-75	PTEN induced kinase 1	Rattus norvegicus	53-58
35124219-4	2022	In addition, we confirmed that RBFOX2-C. showed a significantly stronger localization into stress granules than RBFOX2-N.C. upon sodium arsenite treatment.	sodium arsenite	129-144	RNA binding fox-1 homolog 2	Homo sapiens	31-37
35124219-4	2022	In addition, we confirmed that RBFOX2-C. showed a significantly stronger localization into stress granules than RBFOX2-N.C. upon sodium arsenite treatment.	sodium arsenite	129-144	RNA binding fox-1 homolog 2	Homo sapiens	112-118
35237411-8	2022	The successful KD of PINK1 and Parkin aggravated the NaAsO2-induced damage to mitophagy.	sodium arsenite	53-59	PTEN induced kinase 1	Rattus norvegicus	21-26
35237411-9	2022	The degeneration of mitochondrial vacuoles and the appearance of autophagosomes were detected in the NaAsO2, NaAsO2 + PINK1-KD and NaAsO2 + Parkin-KD groups.	sodium arsenite	109-115	PTEN induced kinase 1	Rattus norvegicus	118-123
35237411-10	2022	NaAsO2 can induce mitophagy in rat hepatocytes, and the silencing of PINK1 and Parkin can aggravate mitochondrial damage during this process.	sodium arsenite	0-6	PTEN induced kinase 1	Rattus norvegicus	69-74
2912370-4	1989	Using radioimmunoassay, it was shown that other agents known to increase the testicular heme oxygenase, sodium arsenate and sodium arsenite, also increased the microsomal content of HO-1.	sodium arsenite	124-139	heme oxygenase 1	Rattus norvegicus	182-186
2777774-1	1989	Platelet-derived growth factor (PDGF), fibroblast growth factor, and heavy metal salts such as sodium arsenite stimulated BALB/c-3T3 cells to synthesize a 31-kDa protein(s) (termed p31) in a concentration-dependent manner.	sodium arsenite	95-110	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	181-184
2791215-0	1989	Effect of sodium arsenite on the induction and turnover of ornithine decarboxylase activity in erythroleukemia cells.	sodium arsenite	10-25	ornithine decarboxylase 1	Homo sapiens	59-82
2791215-1	1989	Sodium arsenite proved effective in preventing the induction of ornithine decarboxylase (ODC) activity elicited by dilution of Friend erythroleukemia cells in fresh medium.	sodium arsenite	0-15	ornithine decarboxylase 1	Homo sapiens	64-87
2791215-1	1989	Sodium arsenite proved effective in preventing the induction of ornithine decarboxylase (ODC) activity elicited by dilution of Friend erythroleukemia cells in fresh medium.	sodium arsenite	0-15	ornithine decarboxylase 1	Homo sapiens	89-92
2791215-4	1989	The half-life of ODC activity, measured after cycloheximide treatment, increased almost six-fold after addition of sodium arsenite.	sodium arsenite	115-130	ornithine decarboxylase 1	Homo sapiens	17-20
2484616-4	1989	We now confirm the nonmutagenicity of sodium arsenite in line G12, a pSV2gpt-transformed V79 (hprt-) cell line, which is able to detect multilocus deletions in addition to point mutations and small deletions.	sodium arsenite	38-53	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	94-98
2484616-6	1989	Sodium arsenite at relatively nontoxic concentrations (5 microM for 24 h or 10 microM for 3 h) is comutagenic with N-methyl-N-nitrosourea (MMU) at the hprt locus in V79 cells.	sodium arsenite	0-15	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	151-155
2484623-12	1989	Both sodium arsenite and sodium arsenate induced a high frequency of methotrexate-resistant 3T6 cells, which were shown to have amplified copies of the dihydrofolate reductase gene.	sodium arsenite	5-20	dihydrofolate reductase	Mus musculus	152-175
3196465-1	1988	Continuous exposure of a Xenopus laevis kidney epithelial cell line, A6, to either heat shock (33 degrees C) or sodium arsenite (50 microM) resulted in transient but markedly different temporal patterns of heat-shock protein (HSP) synthesis and HSP 70 and 30 mRNA accumulation.	sodium arsenite	112-127	heat shock 70kDa protein L homeolog	Xenopus laevis	206-224
3409220-3	1988	The library was constructed from mRNA extracted from the cells treated with sodium arsenite, which stimulates the p32 expression most effectively among various agents so far tested.	sodium arsenite	76-91	complement component 1, q subcomponent binding protein	Mus musculus	114-117
3409220-5	1988	RNA blot analysis has shown that p32 mRNA is induced as early as 0.5 h after the addition of 12-O-tetradecanoyl-phorbol-13-acetate or sodium arsenite.	sodium arsenite	134-149	complement component 1, q subcomponent binding protein	Mus musculus	33-36
2974799-2	1988	In vivo, intron-containing transcripts of the hsp27 gene accumulate in cells stressed by heat or sodium arsenite.	sodium arsenite	97-112	heat shock protein family B (small) member 1	Homo sapiens	46-51
2457504-1	1988	Challenge of mammalian cells with heavy metals or sulfhydryl-reactive agents including sodium arsenite induces the de novo synthesis of a 32-/34-kDa stress protein (p32) (M. M. Caltabiano, T. P. Koestler, G. Poste, and R. G. Greig (1986) J. Biol.	sodium arsenite	87-102	inhibitor of growth family member 2	Homo sapiens	165-168
2457504-4	1988	Here we report that antibody prepared against p32/p34 purified from human A375 melanoma cells immunoprecipitated an antigen of similar molecular mass from a panel of human, rat, and murine cells following challenge with sodium arsenite.	sodium arsenite	220-235	inhibitor of growth family member 2	Homo sapiens	46-49
2457504-4	1988	Here we report that antibody prepared against p32/p34 purified from human A375 melanoma cells immunoprecipitated an antigen of similar molecular mass from a panel of human, rat, and murine cells following challenge with sodium arsenite.	sodium arsenite	220-235	alpha and gamma adaptin binding protein	Homo sapiens	50-53
3196465-7	1988	In conclusion, heat shock and sodium arsenite induce a similar set of HSPs but maximum synthesis of the HSP is temporally separated by 12-24 h.	sodium arsenite	30-45	heat shock 70kDa protein L homeolog	Xenopus laevis	70-73
3196465-1	1988	Continuous exposure of a Xenopus laevis kidney epithelial cell line, A6, to either heat shock (33 degrees C) or sodium arsenite (50 microM) resulted in transient but markedly different temporal patterns of heat-shock protein (HSP) synthesis and HSP 70 and 30 mRNA accumulation.	sodium arsenite	112-127	heat shock 70kDa protein L homeolog	Xenopus laevis	226-229
3196465-1	1988	Continuous exposure of a Xenopus laevis kidney epithelial cell line, A6, to either heat shock (33 degrees C) or sodium arsenite (50 microM) resulted in transient but markedly different temporal patterns of heat-shock protein (HSP) synthesis and HSP 70 and 30 mRNA accumulation.	sodium arsenite	112-127	heat shock 70kDa protein L homeolog	Xenopus laevis	245-248
3196465-2	1988	Heat-shock-induced synthesis of HSPs was detectable within 1 h and reached maximum levels by 2-3 h. While sodium arsenite induced the synthesis of some HSPs within 1 h, maximal HSP synthesis did not occur until 12 h. The pattern of HSP 70 and 30 mRNA accumulation was similar to the response observed at the protein level.	sodium arsenite	106-121	heat shock 70kDa protein L homeolog	Xenopus laevis	32-35
3196465-2	1988	Heat-shock-induced synthesis of HSPs was detectable within 1 h and reached maximum levels by 2-3 h. While sodium arsenite induced the synthesis of some HSPs within 1 h, maximal HSP synthesis did not occur until 12 h. The pattern of HSP 70 and 30 mRNA accumulation was similar to the response observed at the protein level.	sodium arsenite	106-121	heat shock 70kDa protein L homeolog	Xenopus laevis	152-155
3606855-1	1987	Heat shock protein (HSP) synthesis was studied in the Xenopus epithelial cell line A6 in response to heat and sodium arsenite, either singly or together.	sodium arsenite	110-125	heat shock 70kDa protein L homeolog	Xenopus laevis	0-18
3597553-1	1987	After sodium arsenite (100 microM) treatment, the synthesis of three major heat shock protein families (HSPs; Mr = 110,000, 87,000, and 70,000), as studied with one-dimensional gels, was enhanced twofold relative to that of unheated cells.	sodium arsenite	6-21	10 kDa heat shock protein, mitochondrial	Cricetulus griseus	75-93
3412774-0	1988	c-fos mRNA levels are increased by the cellular stressors, heat shock and sodium arsenite.	sodium arsenite	74-89	FBJ osteosarcoma oncogene	Mus musculus	0-5
3412774-3	1988	Our findings demonstrate that c-fos mRNA levels increase transiently under conditions of heat stress or sodium arsenite treatment which induce expression of hsp70 mRNA in cultured cell lines.	sodium arsenite	104-119	FBJ osteosarcoma oncogene	Mus musculus	30-35
3412774-3	1988	Our findings demonstrate that c-fos mRNA levels increase transiently under conditions of heat stress or sodium arsenite treatment which induce expression of hsp70 mRNA in cultured cell lines.	sodium arsenite	104-119	heat shock protein 1B	Mus musculus	157-162
3412774-7	1988	A comparison of relative rates of protein synthesis and c-fos mRNA levels during either heat shock or sodium arsenite treatment suggests that the transient suppression of protein synthesis accompanying these treatments may be one factor responsible for the observed c-fos mRNA induction.	sodium arsenite	102-117	FBJ osteosarcoma oncogene	Mus musculus	56-61
3412774-7	1988	A comparison of relative rates of protein synthesis and c-fos mRNA levels during either heat shock or sodium arsenite treatment suggests that the transient suppression of protein synthesis accompanying these treatments may be one factor responsible for the observed c-fos mRNA induction.	sodium arsenite	102-117	FBJ osteosarcoma oncogene	Mus musculus	266-271
3606855-1	1987	Heat shock protein (HSP) synthesis was studied in the Xenopus epithelial cell line A6 in response to heat and sodium arsenite, either singly or together.	sodium arsenite	110-125	heat shock 70kDa protein L homeolog	Xenopus laevis	20-23
3606855-3	1987	In cultures exposed to 10 microM sodium arsenite at 30 degrees C, HSP synthesis in the 68- to 73-kDa and 29- to 31-kDa regions was much greater than the HSP synthesis in response to each treatment individually.	sodium arsenite	33-48	heat shock 70kDa protein L homeolog	Xenopus laevis	66-69
3606855-3	1987	In cultures exposed to 10 microM sodium arsenite at 30 degrees C, HSP synthesis in the 68- to 73-kDa and 29- to 31-kDa regions was much greater than the HSP synthesis in response to each treatment individually.	sodium arsenite	33-48	heat shock 70kDa protein L homeolog	Xenopus laevis	153-156
3606855-6	1987	Sodium arsenite (10-100 microM) also induced the accumulation of both HSP 70 and 30 mRNAs.	sodium arsenite	0-15	heat shock 70kDa protein L homeolog	Xenopus laevis	70-76
3606855-7	1987	Finally, a mild heat shock (30 degrees C) plus a low concentration of sodium arsenite (10 microM) acted synergistically on HSP 70 and 30 mRNA accumulation in A6 cells.	sodium arsenite	70-85	heat shock 70kDa protein L homeolog	Xenopus laevis	123-126
3606855-8	1987	Thus sodium arsenite and heat act synergistically at the level of both HSP synthesis and HSP mRNA accumulation.	sodium arsenite	5-20	heat shock 70kDa protein L homeolog	Xenopus laevis	71-74
3606855-8	1987	Thus sodium arsenite and heat act synergistically at the level of both HSP synthesis and HSP mRNA accumulation.	sodium arsenite	5-20	heat shock 70kDa protein L homeolog	Xenopus laevis	89-92
3754488-3	1986	p32 might be one of the heat shock proteins because its synthesis was also stimulated by heat shock or sodium arsenite.	sodium arsenite	103-118	complement component 1, q subcomponent binding protein	Mus musculus	0-3
3828114-3	1987	Exposure of Xenopus laevis embryos to other stressors, such as sodium arsenite or ethanol, also induced a developmental stage-dependent accumulation of hsp 70 mRNA.	sodium arsenite	63-78	heat shock 70kDa protein L homeolog	Xenopus laevis	152-158
6841458-0	1983	Induction of thermotolerance and enhanced heat shock protein synthesis in Chinese hamster fibroblasts by sodium arsenite and by ethanol.	sodium arsenite	105-120	10 kDa heat shock protein, mitochondrial	Cricetulus griseus	42-60
3753897-2	1986	Posttreatment of sodium arsenite drastically increases the cytotoxicity, clastogenicity, hypoxanthine-guanine phosphoribosyltransferase mutagenicity, and inhibition of mitosis and cell proliferation induced by MMS.	sodium arsenite	17-32	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	89-135
3753897-1	1986	Pretreatment of sodium arsenite reduces hypoxanthine-guanine phosphoribosyltransferase mutagenicity and overcomes the inhibition of mitosis and cell proliferation but has no apparent effect on the cytotoxicity and clastogenicity in methyl methanesulfonate (MMS)-treated Chinese hamster ovary cells.	sodium arsenite	16-31	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	40-86
3753679-4	1986	Furthermore, the mutagenicity of cis-Pt(II) at the hypoxanthine-guanine phosphoribosyl transferase locus is also potentiated by sodium arsenite in CHO cells.	sodium arsenite	128-143	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	51-98
6424670-2	1984	Here, we demonstrate that this methylation can be modulated by sodium arsenite, a chemical that increases the synthesis of hsp70.	sodium arsenite	63-78	heat shock protein family A (Hsp70) member 2	Gallus gallus	123-128
6841458-3	1983	A causative relationship between heat shock protein synthesis and development of thermotolerance would imply that agents known to induce heat shock protein synthesis, such as sodium arsenite, also induce thermotolerance.	sodium arsenite	175-190	10 kDa heat shock protein, mitochondrial	Cricetulus griseus	33-51
6841458-3	1983	A causative relationship between heat shock protein synthesis and development of thermotolerance would imply that agents known to induce heat shock protein synthesis, such as sodium arsenite, also induce thermotolerance.	sodium arsenite	175-190	10 kDa heat shock protein, mitochondrial	Cricetulus griseus	137-155
6114827-5	1981	Furthermore, disulfides [insulin, glutathione disulfide, L-cystine, and 5,5"-dithiobis (2-nitrobenzoic acid)] known to interact with thioredoxin-dependent enzyme systems inhibited sulindac reduction, as did sodium arsenite, a known inhibitor of thioredoxin reductase.	sodium arsenite	207-222	thioredoxin 1	Rattus norvegicus	133-144
30907158-10	2021	Treatment with GA remarkably improved SA-induced alteration of hematological and histopathological parameters; these protective effects were associated with the reduction of SA-induced elevation of MDA, IL-1beta and NO levels as well as reduction of GSH level and GPx, SOD and CAT activity.	sodium arsenite	174-176	interleukin 1 beta	Rattus norvegicus	203-211
818137-8	1976	The bovine pancreatic lipase appeared to contain sulfhydryl groups which may be essential for the lipolytic activity since p-chloromercuribenzoate, N-ethylmaleimide, sodium arsenite, and iodoacetate inhibited the enzyme.	sodium arsenite	166-181	pancreatic lipase	Bos taurus	11-28
30907158-10	2021	Treatment with GA remarkably improved SA-induced alteration of hematological and histopathological parameters; these protective effects were associated with the reduction of SA-induced elevation of MDA, IL-1beta and NO levels as well as reduction of GSH level and GPx, SOD and CAT activity.	sodium arsenite	174-176	catalase	Rattus norvegicus	277-280
33854955-6	2021	Sodium arsenite caused mild expression of BCL-2 protein> NF-Kb = p53 in the kidney of rats.	sodium arsenite	0-15	BCL2, apoptosis regulator	Rattus norvegicus	42-47
34006163-0	2021	Ameliorative role of inducible nitric oxide synthase inhibitors against sodium arsenite-induced renal and hepatic dysfunction in rats.	sodium arsenite	72-87	nitric oxide synthase 2	Rattus norvegicus	21-52
34006163-2	2021	The present study explored the role of inducible nitric oxide synthase (iNOS) inhibitors against sodium arsenite-induced renal and hepatic dysfunction in rats.	sodium arsenite	97-112	nitric oxide synthase 2	Rattus norvegicus	39-70
34006163-2	2021	The present study explored the role of inducible nitric oxide synthase (iNOS) inhibitors against sodium arsenite-induced renal and hepatic dysfunction in rats.	sodium arsenite	97-112	nitric oxide synthase 2	Rattus norvegicus	72-76
34006163-13	2021	Hence, it is concluded that iNOS inhibitors attenuate sodium arsenite-induced renal and hepatic dysfunction in rats.	sodium arsenite	54-69	nitric oxide synthase 2	Rattus norvegicus	28-32
33609750-4	2021	In our study, we found that the expression of lncRNA DICER1-AS1 was significantly inhibited by sodium arsenite in a dose-dependent manner.	sodium arsenite	95-110	dicer 1, ribonuclease III	Homo sapiens	53-59
33609750-4	2021	In our study, we found that the expression of lncRNA DICER1-AS1 was significantly inhibited by sodium arsenite in a dose-dependent manner.	sodium arsenite	95-110	prostaglandin D2 receptor	Homo sapiens	60-63
33621689-2	2021	The present study demonstrated that prolonged exposure to sodium arsenite at low micromolar range (1-10 muM) reduced Tau 1 (recognizing dephosphorylated tau at residues 189-207) and elevated pS202 tau in differentiated human neuroblastoma SH-SY5Y cells indicating that arsenic increases tau phosphorylation in neurons.	sodium arsenite	58-73	microtubule associated protein tau	Homo sapiens	153-156
33621689-2	2021	The present study demonstrated that prolonged exposure to sodium arsenite at low micromolar range (1-10 muM) reduced Tau 1 (recognizing dephosphorylated tau at residues 189-207) and elevated pS202 tau in differentiated human neuroblastoma SH-SY5Y cells indicating that arsenic increases tau phosphorylation in neurons.	sodium arsenite	58-73	microtubule associated protein tau	Homo sapiens	197-200
33621689-3	2021	Sodium arsenite elevated GSK3beta kinase activity, while GSK3 inhibitors, BIO, SB216763, and lithium, reversed the Tau 1 reduction by sodium arsenite.	sodium arsenite	0-15	glycogen synthase kinase 3 alpha	Homo sapiens	25-33
33621689-3	2021	Sodium arsenite elevated GSK3beta kinase activity, while GSK3 inhibitors, BIO, SB216763, and lithium, reversed the Tau 1 reduction by sodium arsenite.	sodium arsenite	134-149	microtubule associated protein tau	Homo sapiens	115-118
33621689-4	2021	Additionally, sodium arsenite increased levels of active phosphorylation of ERK1/2, and inhibition of ERK1/2 by U0126 partially improved the Tau1 reduction.	sodium arsenite	14-29	mitogen-activated protein kinase 3	Homo sapiens	76-82
33621689-6	2021	Furthermore, sodium arsenite augmented tau phosphorylation in the membrane and cytosolic fractions.	sodium arsenite	13-28	microtubule associated protein tau	Homo sapiens	39-42
33621689-7	2021	Inductions of GSK3 activity by sodium arsenite treatment were observed in the membrane fraction, as evidenced by a reduction of beta-catenin, a protein signaled for degradation following phosphorylation by GSK3.	sodium arsenite	31-46	catenin beta 1	Homo sapiens	128-140
33621689-8	2021	An enhancement of ERK1/2 phosphorylation by sodium arsenite was also witnessed in the cytosol.	sodium arsenite	44-59	mitogen-activated protein kinase 3	Homo sapiens	18-24
33621689-9	2021	Additionally, sodium arsenite increased insoluble tau aggregation.	sodium arsenite	14-29	microtubule associated protein tau	Homo sapiens	50-53
33854955-6	2021	Sodium arsenite caused mild expression of BCL-2 protein> NF-Kb = p53 in the kidney of rats.	sodium arsenite	0-15	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	57-62
33854955-6	2021	Sodium arsenite caused mild expression of BCL-2 protein> NF-Kb = p53 in the kidney of rats.	sodium arsenite	0-15	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	65-68
32776539-0	2021	IRE1alpha/NOX4 signaling pathway mediates ROS-dependent activation of hepatic stellate cells in NaAsO2 -induced liver fibrosis.	sodium arsenite	96-102	NADPH oxidase 4	Rattus norvegicus	10-14
33388378-7	2021	Subsequent results showed that TET1 and TET2 siRNA led to further inhibition of genome 5hmC and a higher level of oxidative stress in NaAsO2-treated HBE cells.	sodium arsenite	134-140	tet methylcytosine dioxygenase 1	Homo sapiens	31-35
33388378-7	2021	Subsequent results showed that TET1 and TET2 siRNA led to further inhibition of genome 5hmC and a higher level of oxidative stress in NaAsO2-treated HBE cells.	sodium arsenite	134-140	tet methylcytosine dioxygenase 2	Homo sapiens	40-44
32930475-3	2021	In this study, we found that the AS3MT was overexpressed in arsenic exposed population, non-small cell lung cancer (NSCLC) tissues, and A549 cells with sodium arsenite (NaAsO2 ) treatment for 48 hours.	sodium arsenite	152-167	arsenite methyltransferase	Homo sapiens	33-38
32930475-3	2021	In this study, we found that the AS3MT was overexpressed in arsenic exposed population, non-small cell lung cancer (NSCLC) tissues, and A549 cells with sodium arsenite (NaAsO2 ) treatment for 48 hours.	sodium arsenite	169-175	arsenite methyltransferase	Homo sapiens	33-38
33497687-8	2021	NaAsO2-treatment resulted in a significant increase in lipid peroxidation (LPO), inducible nitric oxide synthetase (iNOs), and NO levels, with a decrease in the levels of both enzymatic (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and non-enzymatic (glutathione) antioxidant markers.	sodium arsenite	0-6	nitric oxide synthase 2, inducible	Mus musculus	81-114
33497687-8	2021	NaAsO2-treatment resulted in a significant increase in lipid peroxidation (LPO), inducible nitric oxide synthetase (iNOs), and NO levels, with a decrease in the levels of both enzymatic (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and non-enzymatic (glutathione) antioxidant markers.	sodium arsenite	0-6	nitric oxide synthase 2, inducible	Mus musculus	116-120
33497687-8	2021	NaAsO2-treatment resulted in a significant increase in lipid peroxidation (LPO), inducible nitric oxide synthetase (iNOs), and NO levels, with a decrease in the levels of both enzymatic (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and non-enzymatic (glutathione) antioxidant markers.	sodium arsenite	0-6	catalase	Mus musculus	209-217
33497687-8	2021	NaAsO2-treatment resulted in a significant increase in lipid peroxidation (LPO), inducible nitric oxide synthetase (iNOs), and NO levels, with a decrease in the levels of both enzymatic (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and non-enzymatic (glutathione) antioxidant markers.	sodium arsenite	0-6	glutathione reductase	Mus musculus	247-268
33884178-0	2021	Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARgamma pathway against oxidative injury in mice hippocampus.	sodium arsenite	0-15	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118
33884178-0	2021	Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARgamma pathway against oxidative injury in mice hippocampus.	sodium arsenite	0-15	peroxisome proliferator activated receptor gamma	Mus musculus	119-128
33026618-12	2021	In addition, sodium arsenite-induced alteration in hepatic parameters (serum aspartate aminotransferase, alanine transferase, alkaline phosphatase, bilirubin), oxidative stress and histological changes were abrogated by bosentan treatment in rats.	sodium arsenite	13-28	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	77-103
33039867-0	2021	ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.	sodium arsenite	45-51	tumor protein p53	Homo sapiens	150-153
33387887-5	2021	Time-lapse imaging showed that TDP-43 aggregates appeared in the nucleus within 30 min of treatment with sodium arsenite.	sodium arsenite	105-120	TAR DNA binding protein	Homo sapiens	31-37
33039867-6	2021	Nanog, SOX-2 and ALDH1A1, three markers of cancer stemness, were upregulated in NaAsO2-exposed PC-3 spheres.	sodium arsenite	80-86	Nanog homeobox	Homo sapiens	0-5
33039867-6	2021	Nanog, SOX-2 and ALDH1A1, three markers of cancer stemness, were upregulated in NaAsO2-exposed PC-3 spheres.	sodium arsenite	80-86	SRY-box transcription factor 2	Homo sapiens	7-12
33039867-6	2021	Nanog, SOX-2 and ALDH1A1, three markers of cancer stemness, were upregulated in NaAsO2-exposed PC-3 spheres.	sodium arsenite	80-86	aldehyde dehydrogenase 1 family member A1	Homo sapiens	17-24
33039867-8	2021	Histone H2AX phosphorylation on Ser139, an indicator for DNA double-strand break, was upregulated in NaAsO2-exposed DU145 and PC-3 cells.	sodium arsenite	101-107	H2A.X variant histone	Homo sapiens	0-12
33039867-9	2021	ATM phosphorylation on Ser1981, a key sensor of genotoxic stress, was rapidly elevated in NaAsO2-exposed DU145 cells.	sodium arsenite	90-96	ATM serine/threonine kinase	Homo sapiens	0-3
33039867-10	2021	Phosphor-p53, a downstream molecule of ATM signaling, and p21, a direct target of p53, were upregulated in NaAsO2-exposed DU145 cells.	sodium arsenite	107-113	tumor protein p53	Homo sapiens	9-12
33039867-10	2021	Phosphor-p53, a downstream molecule of ATM signaling, and p21, a direct target of p53, were upregulated in NaAsO2-exposed DU145 cells.	sodium arsenite	107-113	ATM serine/threonine kinase	Homo sapiens	39-42
33039867-10	2021	Phosphor-p53, a downstream molecule of ATM signaling, and p21, a direct target of p53, were upregulated in NaAsO2-exposed DU145 cells.	sodium arsenite	107-113	H3 histone pseudogene 16	Homo sapiens	58-61
33039867-10	2021	Phosphor-p53, a downstream molecule of ATM signaling, and p21, a direct target of p53, were upregulated in NaAsO2-exposed DU145 cells.	sodium arsenite	107-113	tumor protein p53	Homo sapiens	82-85
33039867-11	2021	Unexpectedly, p21 was also elevated in NaAsO2-exposed p53-null PC-3 cells.	sodium arsenite	39-45	H3 histone pseudogene 16	Homo sapiens	14-17
33039867-11	2021	Unexpectedly, p21 was also elevated in NaAsO2-exposed p53-null PC-3 cells.	sodium arsenite	39-45	tumor protein p53	Homo sapiens	54-57
33039867-12	2021	Antioxidant NAC alleviated NaAsO2-induced ATM phosphorylation, cell cycle arrest, and subsequent stemness enhancement and chemoresistance in both DU145 and PC-3 cells.	sodium arsenite	27-33	synuclein alpha	Homo sapiens	12-15
33039867-12	2021	Antioxidant NAC alleviated NaAsO2-induced ATM phosphorylation, cell cycle arrest, and subsequent stemness enhancement and chemoresistance in both DU145 and PC-3 cells.	sodium arsenite	27-33	ATM serine/threonine kinase	Homo sapiens	42-45
33039867-13	2021	These results suggest that ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.	sodium arsenite	72-78	tumor protein p53	Homo sapiens	177-180
33242462-5	2021	Moreover, NaAsO2 toxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2-related factor 2) gene expression level, and elevations in malondialdehyde.	sodium arsenite	10-16	catalase	Mus musculus	73-76
33242462-7	2021	Immunohistochemical analysis of testis sections of NaAsO2-treated mice showed high caspase-3 expression.	sodium arsenite	51-57	caspase 3	Mus musculus	83-92
33242462-5	2021	Moreover, NaAsO2 toxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2-related factor 2) gene expression level, and elevations in malondialdehyde.	sodium arsenite	10-16	peroxiredoxin 6 pseudogene 2	Mus musculus	78-81
33242462-5	2021	Moreover, NaAsO2 toxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2-related factor 2) gene expression level, and elevations in malondialdehyde.	sodium arsenite	10-16	nuclear receptor subfamily 3, group C, member 1	Mus musculus	83-85
33242462-5	2021	Moreover, NaAsO2 toxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2-related factor 2) gene expression level, and elevations in malondialdehyde.	sodium arsenite	10-16	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
33242462-5	2021	Moreover, NaAsO2 toxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2-related factor 2) gene expression level, and elevations in malondialdehyde.	sodium arsenite	10-16	nuclear factor, erythroid derived 2, like 2	Mus musculus	122-165
33053406-2	2020	Considering that arsenic has the potential to inhibit autophagic flux, it was hypothesized that arsenite (NaAsO2) may interplay with LRRK2 and alpha-Synuclein, affecting their phosphorylation in brain regions prone to neurodegeneration.	sodium arsenite	106-112	leucine-rich repeat kinase 2	Mus musculus	133-138
33025330-9	2020	In WT or MT hSOD1-transfected HEK293 and NSC-34 cells, the formation of TIA-1-positive stress granules was delayed in MTSOD1 by sodium arsenite treatment.	sodium arsenite	128-143	superoxide dismutase 1	Homo sapiens	12-17
33025330-9	2020	In WT or MT hSOD1-transfected HEK293 and NSC-34 cells, the formation of TIA-1-positive stress granules was delayed in MTSOD1 by sodium arsenite treatment.	sodium arsenite	128-143	cytotoxic granule-associated RNA binding protein 1	Mus musculus	72-77
33025330-9	2020	In WT or MT hSOD1-transfected HEK293 and NSC-34 cells, the formation of TIA-1-positive stress granules was delayed in MTSOD1 by sodium arsenite treatment.	sodium arsenite	128-143	superoxide dismutase 1, soluble	Mus musculus	118-124
33256086-0	2020	Anti-Tumor Effects of Sodium Meta-Arsenite in Glioblastoma Cells with Higher Akt Activities.	sodium arsenite	22-42	AKT serine/threonine kinase 1	Homo sapiens	77-80
33256086-3	2020	Sodium meta-arsenite, KML001 is an orally bioavailable, water-soluble, and trivalent arsenical and it shows antitumoral effects in several solid tumor cells via inhibiting oncogenic signaling, including Akt and MAPK.	sodium arsenite	22-28	AKT serine/threonine kinase 1	Homo sapiens	203-206
33256086-4	2020	Here, we evaluated the effect of sodium meta-arsenite, KML001, on the growth of human glioblastoma cell lines with different PTEN expression status and Akt activation, including PTEN-deficient cells (U87-MG and U251) and PTEN-positive cells (LN229).	sodium arsenite	33-53	phosphatase and tensin homolog	Homo sapiens	125-129
33256086-4	2020	Here, we evaluated the effect of sodium meta-arsenite, KML001, on the growth of human glioblastoma cell lines with different PTEN expression status and Akt activation, including PTEN-deficient cells (U87-MG and U251) and PTEN-positive cells (LN229).	sodium arsenite	33-53	AKT serine/threonine kinase 1	Homo sapiens	152-155
33256086-5	2020	The growth-inhibitory effect of KML001 was stronger in U87-MG and U251 cells, which exhibited higher Akt activity than LN229 cells.	sodium arsenite	32-38	AKT serine/threonine kinase 1	Homo sapiens	101-104
32882370-4	2021	We used a sodium arsenite-induced cellular stress model to investigate the role of hypusinated eIF5A (eIF5AHypK50) in governing TDP-43 cytoplasmic mislocalization and accumulation in stress granule.	sodium arsenite	10-25	eukaryotic translation initiation factor 5A	Homo sapiens	95-100
32882370-4	2021	We used a sodium arsenite-induced cellular stress model to investigate the role of hypusinated eIF5A (eIF5AHypK50) in governing TDP-43 cytoplasmic mislocalization and accumulation in stress granule.	sodium arsenite	10-25	eukaryotic translation initiation factor 5A	Homo sapiens	102-113
32882370-4	2021	We used a sodium arsenite-induced cellular stress model to investigate the role of hypusinated eIF5A (eIF5AHypK50) in governing TDP-43 cytoplasmic mislocalization and accumulation in stress granule.	sodium arsenite	10-25	TAR DNA binding protein	Homo sapiens	128-134
32816178-8	2021	The expression of HOTAIR was considerably high in the presence of NaAsO2 and MMA but showed no difference in DMA compared with control group.	sodium arsenite	66-72	HOX transcript antisense RNA	Homo sapiens	18-24
32816178-9	2021	And LincRNA-p21 expression was increased in the presence of NaAsO2, MMA, and DMA.	sodium arsenite	60-66	tumor protein p53 pathway corepressor 1	Homo sapiens	4-15
32816178-11	2021	Compared with the control group, treatment of A549 cells with NaAsO2/S-adenosylmethionine (SAM) and NaAsO2/glutathione (GSH) combination increased HOTAIR and LincRNA-p21 expression.	sodium arsenite	62-68	HOX transcript antisense RNA	Homo sapiens	147-153
32816178-11	2021	Compared with the control group, treatment of A549 cells with NaAsO2/S-adenosylmethionine (SAM) and NaAsO2/glutathione (GSH) combination increased HOTAIR and LincRNA-p21 expression.	sodium arsenite	62-68	tumor protein p53 pathway corepressor 1	Homo sapiens	158-169
32816178-11	2021	Compared with the control group, treatment of A549 cells with NaAsO2/S-adenosylmethionine (SAM) and NaAsO2/glutathione (GSH) combination increased HOTAIR and LincRNA-p21 expression.	sodium arsenite	100-106	HOX transcript antisense RNA	Homo sapiens	147-153
32816178-11	2021	Compared with the control group, treatment of A549 cells with NaAsO2/S-adenosylmethionine (SAM) and NaAsO2/glutathione (GSH) combination increased HOTAIR and LincRNA-p21 expression.	sodium arsenite	100-106	tumor protein p53 pathway corepressor 1	Homo sapiens	158-169
32816178-12	2021	The expression of LincRNA-p21 in combination of NaAsO2/GSH was significantly decreased compared with NaAsO2 alone.	sodium arsenite	48-54	tumor protein p53 pathway corepressor 1	Homo sapiens	18-29
32816178-12	2021	The expression of LincRNA-p21 in combination of NaAsO2/GSH was significantly decreased compared with NaAsO2 alone.	sodium arsenite	101-107	tumor protein p53 pathway corepressor 1	Homo sapiens	18-29
33327938-11	2020	RESULTS: We detected RFP+ neurons and glia in the brains of postnatal mice that had been prenatally exposed to alcohol or sodium arsenite.	sodium arsenite	122-137	tripartite motif-containing 27	Mus musculus	21-24
33327938-12	2020	In animals prenatally exposed to sodium arsenite, we also detected reduced excitability in RFP+ cortical neurons.	sodium arsenite	33-48	tripartite motif-containing 27	Mus musculus	91-94
32844245-4	2020	We demonstrate that continuous exposure of HepaRG cells to 1 microM sodium arsenite (NaAsO2) for 14 days resulted in substantial cytosine DNA demethylation and hypermethylation across the genome, among which the claudin 14 (CLDN14) gene was hypermethylated and the most down-regulated gene.	sodium arsenite	68-83	claudin 14	Homo sapiens	212-222
32844245-4	2020	We demonstrate that continuous exposure of HepaRG cells to 1 microM sodium arsenite (NaAsO2) for 14 days resulted in substantial cytosine DNA demethylation and hypermethylation across the genome, among which the claudin 14 (CLDN14) gene was hypermethylated and the most down-regulated gene.	sodium arsenite	68-83	claudin 14	Homo sapiens	224-230
32844245-4	2020	We demonstrate that continuous exposure of HepaRG cells to 1 microM sodium arsenite (NaAsO2) for 14 days resulted in substantial cytosine DNA demethylation and hypermethylation across the genome, among which the claudin 14 (CLDN14) gene was hypermethylated and the most down-regulated gene.	sodium arsenite	85-91	claudin 14	Homo sapiens	212-222
32844245-4	2020	We demonstrate that continuous exposure of HepaRG cells to 1 microM sodium arsenite (NaAsO2) for 14 days resulted in substantial cytosine DNA demethylation and hypermethylation across the genome, among which the claudin 14 (CLDN14) gene was hypermethylated and the most down-regulated gene.	sodium arsenite	85-91	claudin 14	Homo sapiens	224-230
33053406-2	2020	Considering that arsenic has the potential to inhibit autophagic flux, it was hypothesized that arsenite (NaAsO2) may interplay with LRRK2 and alpha-Synuclein, affecting their phosphorylation in brain regions prone to neurodegeneration.	sodium arsenite	106-112	synuclein, alpha	Mus musculus	143-158
32519758-7	2020	NaAsO2 exposure was associated with marked increases in renal inflammatory marker (interleukin-1beta and tumor necrosis factor-alpha) and apoptosis indicators including Bax and caspase-3 levels contaminant with a marked decrease in Bcl-2, an anti-apoptotic protein, in the NaAsO2- treated group compared with the control group.	sodium arsenite	0-6	interleukin 1 beta	Mus musculus	83-100
32544768-5	2020	Additionally, NaAsO2 upregulated the level of oxidized mitochondrial DNA (ox-mtDNA) and mitophagy, thereby activating the NLRP3 inflammasome in SD rat liver.	sodium arsenite	14-20	NLR family, pyrin domain containing 3	Rattus norvegicus	122-127
32544768-6	2020	In vitro, we demonstrated that NaAsO2-induced IR depended upon the NLRP3 inflammasome activation.	sodium arsenite	31-37	NLR family, pyrin domain containing 3	Rattus norvegicus	67-72
32607937-8	2020	Exposure of Neuro2A cells to low concentrations of the hypoxic stress inducer cobalt chloride, or to sodium arsenite, an oxidative stressor, also increases cellular proSAAS content and reduces its secretion.	sodium arsenite	101-116	proprotein convertase subtilisin/kexin type 1 inhibitor	Mus musculus	165-172
32519758-7	2020	NaAsO2 exposure was associated with marked increases in renal inflammatory marker (interleukin-1beta and tumor necrosis factor-alpha) and apoptosis indicators including Bax and caspase-3 levels contaminant with a marked decrease in Bcl-2, an anti-apoptotic protein, in the NaAsO2- treated group compared with the control group.	sodium arsenite	0-6	tumor necrosis factor	Mus musculus	105-132
32519758-7	2020	NaAsO2 exposure was associated with marked increases in renal inflammatory marker (interleukin-1beta and tumor necrosis factor-alpha) and apoptosis indicators including Bax and caspase-3 levels contaminant with a marked decrease in Bcl-2, an anti-apoptotic protein, in the NaAsO2- treated group compared with the control group.	sodium arsenite	0-6	BCL2-associated X protein	Mus musculus	169-172
32519758-7	2020	NaAsO2 exposure was associated with marked increases in renal inflammatory marker (interleukin-1beta and tumor necrosis factor-alpha) and apoptosis indicators including Bax and caspase-3 levels contaminant with a marked decrease in Bcl-2, an anti-apoptotic protein, in the NaAsO2- treated group compared with the control group.	sodium arsenite	0-6	caspase 3	Mus musculus	177-186
32519758-7	2020	NaAsO2 exposure was associated with marked increases in renal inflammatory marker (interleukin-1beta and tumor necrosis factor-alpha) and apoptosis indicators including Bax and caspase-3 levels contaminant with a marked decrease in Bcl-2, an anti-apoptotic protein, in the NaAsO2- treated group compared with the control group.	sodium arsenite	0-6	B cell leukemia/lymphoma 2	Mus musculus	232-237
32531573-5	2020	Our results showed that sodium arsenite treatment significantly reduced insulin secretion in pancreatic islets.	sodium arsenite	24-39	pancreatic and duodenal homeobox 1	Rattus norvegicus	93-103
32506763-5	2020	Results showed that death receptor 5 (DR5) was a mediator of NaAsO2 -induced apoptosis by enhancing construction of the death-inducing signaling complex (DISC).	sodium arsenite	61-67	TNF receptor superfamily member 10b	Homo sapiens	20-36
32506763-5	2020	Results showed that death receptor 5 (DR5) was a mediator of NaAsO2 -induced apoptosis by enhancing construction of the death-inducing signaling complex (DISC).	sodium arsenite	61-67	TNF receptor superfamily member 10b	Homo sapiens	38-41
32506763-7	2020	Further results showed that NaAsO2 increased expression in biomarker of endoplasmic reticulum (ER) stress and activated the protein kinase R-like ER kinase (PERK)-eukaryotic translation initiation 2alpha (eIF2alpha)-activating transcription factor 4 (ATF4) pathway.	sodium arsenite	28-34	eukaryotic translation initiation factor 2A	Homo sapiens	205-214
32506763-7	2020	Further results showed that NaAsO2 increased expression in biomarker of endoplasmic reticulum (ER) stress and activated the protein kinase R-like ER kinase (PERK)-eukaryotic translation initiation 2alpha (eIF2alpha)-activating transcription factor 4 (ATF4) pathway.	sodium arsenite	28-34	activating transcription factor 4	Homo sapiens	216-249
32506763-7	2020	Further results showed that NaAsO2 increased expression in biomarker of endoplasmic reticulum (ER) stress and activated the protein kinase R-like ER kinase (PERK)-eukaryotic translation initiation 2alpha (eIF2alpha)-activating transcription factor 4 (ATF4) pathway.	sodium arsenite	28-34	activating transcription factor 4	Homo sapiens	251-255
32506763-8	2020	PERK inhibitor and ATF4 siRNA significantly attenuated NaAsO2 -induced CHOP and DR5 expressions.	sodium arsenite	55-61	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	0-4
32506763-8	2020	PERK inhibitor and ATF4 siRNA significantly attenuated NaAsO2 -induced CHOP and DR5 expressions.	sodium arsenite	55-61	activating transcription factor 4	Homo sapiens	19-23
32506763-8	2020	PERK inhibitor and ATF4 siRNA significantly attenuated NaAsO2 -induced CHOP and DR5 expressions.	sodium arsenite	55-61	DNA damage inducible transcript 3	Homo sapiens	71-75
32506763-8	2020	PERK inhibitor and ATF4 siRNA significantly attenuated NaAsO2 -induced CHOP and DR5 expressions.	sodium arsenite	55-61	TNF receptor superfamily member 10b	Homo sapiens	80-83
32506763-10	2020	Taken together, the results indicate that ROS-mediated PERK-eIF2alpha-ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP-DR5 signaling in L-02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic-induced hepatotoxicity.	sodium arsenite	96-102	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	55-59
32506763-10	2020	Taken together, the results indicate that ROS-mediated PERK-eIF2alpha-ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP-DR5 signaling in L-02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic-induced hepatotoxicity.	sodium arsenite	96-102	eukaryotic translation initiation factor 2A	Homo sapiens	60-69
32506763-10	2020	Taken together, the results indicate that ROS-mediated PERK-eIF2alpha-ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP-DR5 signaling in L-02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic-induced hepatotoxicity.	sodium arsenite	96-102	activating transcription factor 4	Homo sapiens	70-74
32506763-10	2020	Taken together, the results indicate that ROS-mediated PERK-eIF2alpha-ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP-DR5 signaling in L-02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic-induced hepatotoxicity.	sodium arsenite	96-102	DNA damage inducible transcript 3	Homo sapiens	184-188
32506763-10	2020	Taken together, the results indicate that ROS-mediated PERK-eIF2alpha-ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP-DR5 signaling in L-02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic-induced hepatotoxicity.	sodium arsenite	96-102	TNF receptor superfamily member 10b	Homo sapiens	189-192
32531573-6	2020	It was revealed that the methylation of glucose transporter 2 (Glut2) gene was changed at two cytosine-phosphate-guanine (CpG) sites (-1743, -1734) in the promoter region of the sodium arsenite-treated group comparing to the control.	sodium arsenite	178-193	solute carrier family 2 member 2	Rattus norvegicus	40-61
32531573-6	2020	It was revealed that the methylation of glucose transporter 2 (Glut2) gene was changed at two cytosine-phosphate-guanine (CpG) sites (-1743, -1734) in the promoter region of the sodium arsenite-treated group comparing to the control.	sodium arsenite	178-193	solute carrier family 2 member 2	Rattus norvegicus	63-68
32531573-8	2020	Measuring the gene expression level showed increase in Glut2 expression, while the expression of insulin (INS) and Pdx1 were significantly affected by sodium arsenite treatment.	sodium arsenite	151-166	pancreatic and duodenal homeobox 1	Rattus norvegicus	115-119
32531573-9	2020	This study revealed that exposure to sodium arsenite changed the DNA methylation pattern of Glut2, a key transporter of glucose entry into the pancreatic beta cells (beta-cells).	sodium arsenite	37-52	solute carrier family 2 member 2	Rattus norvegicus	92-97
32531573-9	2020	This study revealed that exposure to sodium arsenite changed the DNA methylation pattern of Glut2, a key transporter of glucose entry into the pancreatic beta cells (beta-cells).	sodium arsenite	37-52	pancreatic and duodenal homeobox 1	Rattus norvegicus	143-153
32531574-9	2020	In 1.5 mM NaAsO2 group, the decrease of igfbp3 and igfbp5b was almost obvious, about 78.2% and 72.2%.	sodium arsenite	10-16	insulin-like growth factor binding protein 3	Danio rerio	40-46
32531574-9	2020	In 1.5 mM NaAsO2 group, the decrease of igfbp3 and igfbp5b was almost obvious, about 78.2% and 72.2%.	sodium arsenite	10-16	insulin-like growth factor binding protein 5b	Danio rerio	51-58
33241020-11	2020	Furthermore, knockdown of GRP78 to alleviate ER stress, or overexpression of SERCA2 to restore intracellular calcium homeostasis can inhibit the NaAsO2 effect.	sodium arsenite	145-151	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	77-83
33241020-11	2020	Furthermore, knockdown of GRP78 to alleviate ER stress, or overexpression of SERCA2 to restore intracellular calcium homeostasis can inhibit the NaAsO2 effect.	sodium arsenite	145-151	heat shock protein family A (Hsp70) member 5	Homo sapiens	26-31
33241020-9	2020	Furthermore, after knocking down GRP78 [endoplasmic reticulum (ER) chaperone BiP] or overexpressing of SERCA2 (ATPase sarcoplasmic/ER Ca2+ transporting 2) in NaAsO2-induced LX2 cells, we detected the changes in ER stress and calcium homeostasis in LX2 cells.	sodium arsenite	158-164	heat shock protein family A (Hsp70) member 5	Homo sapiens	33-38
33241020-9	2020	Furthermore, after knocking down GRP78 [endoplasmic reticulum (ER) chaperone BiP] or overexpressing of SERCA2 (ATPase sarcoplasmic/ER Ca2+ transporting 2) in NaAsO2-induced LX2 cells, we detected the changes in ER stress and calcium homeostasis in LX2 cells.	sodium arsenite	158-164	heat shock protein family A (Hsp70) member 5	Homo sapiens	77-80
33241020-9	2020	Furthermore, after knocking down GRP78 [endoplasmic reticulum (ER) chaperone BiP] or overexpressing of SERCA2 (ATPase sarcoplasmic/ER Ca2+ transporting 2) in NaAsO2-induced LX2 cells, we detected the changes in ER stress and calcium homeostasis in LX2 cells.	sodium arsenite	158-164	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	103-109
33241020-10	2020	Results: NaAsO2 exposure promoted apoptosis, increased ECM secretion, produced ER stress, and disrupted calcium homeostasis, which could be attenuated by oxymatrine treatment.	sodium arsenite	9-15	multimerin 1	Homo sapiens	55-58
33241020-12	2020	Conclusions: Oxymatrine treatment could improve calcium homeostasis and attenuate ER stress to reverse NaAsO2-induced HSC activation and ECM secretion, which are the significant phenotypes of HF.	sodium arsenite	103-109	fucosyltransferase 1 (H blood group)	Homo sapiens	118-121
32474354-7	2020	RESULTS: The data showed that sodium arsenite and DMA exposure significantly increased the tissue arsenic contents, ROS, TBARS levels, catalase, SOD activities and significantly decreased GSH level which might be responsible for an increased 8-OHdG level.	sodium arsenite	30-45	catalase	Rattus norvegicus	135-143
32905139-4	2020	In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes.	sodium arsenite	84-90	DNA methyltransferase 1	Homo sapiens	155-160
32905139-4	2020	In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes.	sodium arsenite	84-90	forkhead box P3	Homo sapiens	165-170
32905139-4	2020	In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes.	sodium arsenite	84-90	forkhead box P3	Homo sapiens	248-253
32905139-4	2020	In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes.	sodium arsenite	84-90	interleukin 10	Homo sapiens	342-356
32905139-4	2020	In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes.	sodium arsenite	84-90	interleukin 10	Homo sapiens	358-363
32905139-4	2020	In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes.	sodium arsenite	84-90	interleukin 10	Homo sapiens	369-383
32905139-4	2020	In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes.	sodium arsenite	84-90	CD4 molecule	Homo sapiens	421-424
32905139-4	2020	In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes.	sodium arsenite	84-90	CD8a molecule	Homo sapiens	426-429
32760496-7	2020	Splenic NF-kappaB, MAPK and NRF2 protein levels by treatment of 25 mg/L NaAsO2 for 1, 3 and 12 months and 25 mg/L and 50 mg/L NaAsO2 for 12 months were assessed by western blot.	sodium arsenite	72-78	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	8-17
32201329-6	2020	In this study, we found that low-dose sodium arsenite (As (III)) repressed major airway mucins-MUC5AC and MUC5B at both mRNA and protein levels.	sodium arsenite	38-53	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	95-101
32278034-8	2020	When the ERK signaling inhibitor PD98095 was used, there was a similar result that mitophagy was reduced though in contrast with CsA the apoptosis rate was also decreased compared with NaAsO2 alone.	sodium arsenite	185-191	mitogen-activated protein kinase 1	Homo sapiens	9-12
32278034-9	2020	This result, along with the increased levels of ERK measured here in response to NaAsO2, indicates that ERK activation is a second key molecular response to NaAsO2 through the activation of both apoptosis and mitophagy.	sodium arsenite	81-87	mitogen-activated protein kinase 1	Homo sapiens	48-51
32278034-9	2020	This result, along with the increased levels of ERK measured here in response to NaAsO2, indicates that ERK activation is a second key molecular response to NaAsO2 through the activation of both apoptosis and mitophagy.	sodium arsenite	81-87	mitogen-activated protein kinase 1	Homo sapiens	104-107
32278034-9	2020	This result, along with the increased levels of ERK measured here in response to NaAsO2, indicates that ERK activation is a second key molecular response to NaAsO2 through the activation of both apoptosis and mitophagy.	sodium arsenite	157-163	mitogen-activated protein kinase 1	Homo sapiens	48-51
32278034-9	2020	This result, along with the increased levels of ERK measured here in response to NaAsO2, indicates that ERK activation is a second key molecular response to NaAsO2 through the activation of both apoptosis and mitophagy.	sodium arsenite	157-163	mitogen-activated protein kinase 1	Homo sapiens	104-107
32278034-10	2020	Thus the results with CsA indicate that the likely key biological event in NaAsO2 toxicity is at the level of the mitochondria leading to cytochrome c release and apoptosis.	sodium arsenite	75-81	cytochrome c, somatic	Homo sapiens	138-150
32278034-11	2020	Mitophagy is increased in response to a secondary effect of NaAsO2 on ERK signaling that activates both mitophagy and apoptosis.	sodium arsenite	60-66	mitogen-activated protein kinase 1	Homo sapiens	70-73
32278034-13	2020	When ERK signaling is inhibited by PD98095 both the levels of apoptosis and mitophagy are decreased compared with the response produced by NaAsO2 alone in comparison to the inhibition of mitophagy by CsA that reduced mitophagy but dramatically increased apoptosis in response.	sodium arsenite	139-145	mitogen-activated protein kinase 1	Homo sapiens	5-8
32696740-0	2020	[Injury of L-02 hepatocytes induced by NaAsO2 is related to down-regulated expression of p14ARF and increased expression of MDM2 and p53].	sodium arsenite	39-45	transformed mouse 3T3 cell double minute 2	Mus musculus	124-128
32696740-0	2020	[Injury of L-02 hepatocytes induced by NaAsO2 is related to down-regulated expression of p14ARF and increased expression of MDM2 and p53].	sodium arsenite	39-45	transformation related protein 53, pseudogene	Mus musculus	133-136
32696740-1	2020	Objective To investigate the effects of sodium arsenite (NaAsO2) on p14 alternative reading frame (p14ARF), murine double minute 2 (MDM2) and p53 expressions in L-02 hepatocytes.	sodium arsenite	40-55	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	68-71
32696740-1	2020	Objective To investigate the effects of sodium arsenite (NaAsO2) on p14 alternative reading frame (p14ARF), murine double minute 2 (MDM2) and p53 expressions in L-02 hepatocytes.	sodium arsenite	57-63	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	68-71
32696740-9	2020	Conclusion The injury of L-02 hepatocytes induced by NaAsO2 may be related to the down-regulation of p14ARF expression and the up-regulation of p53 and MDM2 expression.	sodium arsenite	53-59	transformation related protein 53, pseudogene	Mus musculus	144-147
32696740-9	2020	Conclusion The injury of L-02 hepatocytes induced by NaAsO2 may be related to the down-regulation of p14ARF expression and the up-regulation of p53 and MDM2 expression.	sodium arsenite	53-59	transformed mouse 3T3 cell double minute 2	Mus musculus	152-156
32197950-5	2020	Using letrozole (an aromatase inhibitor) and G-15 (a GPER1-selective antagonist), we demonstrated that sodium arsenite-induced proliferation and migration is mediated by induction of aromatase enzyme and, at least in part, by GPER1 activation in MDA-MB-231 and MDA-MB-453 cells.	sodium arsenite	103-118	G protein-coupled estrogen receptor 1	Homo sapiens	226-231
32197950-6	2020	Sodium arsenite induced phosphorylation of Src that participated in sodium arsenite-induced aromatase activity, and -cell proliferation of MDA-MB-231 cell line.	sodium arsenite	0-15	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	43-46
32197950-7	2020	Overall, data suggests that sodium arsenite induces a positive-feedback loop, resulting in the promotion and progression of BCa cells, through induction of aromatase activity, E2 production, GPER1 stimulation, and Src activation.	sodium arsenite	28-43	G protein-coupled estrogen receptor 1	Homo sapiens	191-196
32197950-7	2020	Overall, data suggests that sodium arsenite induces a positive-feedback loop, resulting in the promotion and progression of BCa cells, through induction of aromatase activity, E2 production, GPER1 stimulation, and Src activation.	sodium arsenite	28-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	214-217
32278034-0	2020	PINK1/Parkin-mediated mitophagy is involved in NaAsO2-induced apoptosis of human hepatic cells through activation of ERK signaling.	sodium arsenite	47-53	PTEN induced kinase 1	Homo sapiens	0-5
32278034-0	2020	PINK1/Parkin-mediated mitophagy is involved in NaAsO2-induced apoptosis of human hepatic cells through activation of ERK signaling.	sodium arsenite	47-53	mitogen-activated protein kinase 1	Homo sapiens	117-120
32278034-2	2020	Here we examined NaAsO2-induced mitochondrial damage in the L-02 cell led to mitochondrial depolarization and cytochrome c release, mitophagy, apoptosis in a dose response manner.	sodium arsenite	17-23	cytochrome c, somatic	Homo sapiens	110-122
32197950-3	2020	Herein, was studied the role of aromatase activation and the GPER1 pathway on sodium arsenite-induced promotion and progression of MDA-MB-231 and MDA-MB-453 BCa cell lines.	sodium arsenite	78-93	G protein-coupled estrogen receptor 1	Homo sapiens	61-66
32197950-5	2020	Using letrozole (an aromatase inhibitor) and G-15 (a GPER1-selective antagonist), we demonstrated that sodium arsenite-induced proliferation and migration is mediated by induction of aromatase enzyme and, at least in part, by GPER1 activation in MDA-MB-231 and MDA-MB-453 cells.	sodium arsenite	103-118	G protein-coupled estrogen receptor 1	Homo sapiens	53-58
32301004-0	2020	The role of PSMB5 in sodium arsenite-induced oxidative stress in L-02 cells.	sodium arsenite	21-36	proteasome 20S subunit beta 5	Homo sapiens	12-17
32301004-4	2020	This paper aims to study the role and mechanism of PSMB5 in sodium arsenite (NaAsO2)-induced oxidative stress liver injury in L-02 cells.	sodium arsenite	60-75	proteasome 20S subunit beta 5	Homo sapiens	51-56
32301004-4	2020	This paper aims to study the role and mechanism of PSMB5 in sodium arsenite (NaAsO2)-induced oxidative stress liver injury in L-02 cells.	sodium arsenite	77-83	proteasome 20S subunit beta 5	Homo sapiens	51-56
32301004-7	2020	The results demonstrated that NaAsO2 could induce oxidative stress-induced liver injury and the activity of 20S proteasome and the protein expression of PSMB5, SOD1, and GPx1 decreased.	sodium arsenite	30-36	proteasome 20S subunit beta 5	Homo sapiens	153-158
32301004-7	2020	The results demonstrated that NaAsO2 could induce oxidative stress-induced liver injury and the activity of 20S proteasome and the protein expression of PSMB5, SOD1, and GPx1 decreased.	sodium arsenite	30-36	superoxide dismutase 1	Homo sapiens	160-164
32301004-7	2020	The results demonstrated that NaAsO2 could induce oxidative stress-induced liver injury and the activity of 20S proteasome and the protein expression of PSMB5, SOD1, and GPx1 decreased.	sodium arsenite	30-36	glutathione peroxidase 1	Homo sapiens	170-174
32301004-9	2020	After MG132 or PSMB5-siRNA pretreatment, and then L-02 cells were treated with NaAsO2, the gene expression of PSMB remarkably decreased; however, the protein expression of SOD1 and GPx1 increased.	sodium arsenite	79-85	proteasome 20S subunit beta 5	Homo sapiens	15-20
32301004-9	2020	After MG132 or PSMB5-siRNA pretreatment, and then L-02 cells were treated with NaAsO2, the gene expression of PSMB remarkably decreased; however, the protein expression of SOD1 and GPx1 increased.	sodium arsenite	79-85	superoxide dismutase 1	Homo sapiens	172-176
32301004-9	2020	After MG132 or PSMB5-siRNA pretreatment, and then L-02 cells were treated with NaAsO2, the gene expression of PSMB remarkably decreased; however, the protein expression of SOD1 and GPx1 increased.	sodium arsenite	79-85	glutathione peroxidase 1	Homo sapiens	181-185
32301004-10	2020	Overall, NaAsO2 exposure could induce oxidative stress liver injury and low expression of PSMB5 in L-02 cells, and PSMB5 might play an important role in the regulation of oxidative stress by regulating the expression of SOD1 and Gpx1.	sodium arsenite	9-15	proteasome 20S subunit beta 5	Homo sapiens	90-95
32301004-10	2020	Overall, NaAsO2 exposure could induce oxidative stress liver injury and low expression of PSMB5 in L-02 cells, and PSMB5 might play an important role in the regulation of oxidative stress by regulating the expression of SOD1 and Gpx1.	sodium arsenite	9-15	superoxide dismutase 1	Homo sapiens	220-224
32301004-10	2020	Overall, NaAsO2 exposure could induce oxidative stress liver injury and low expression of PSMB5 in L-02 cells, and PSMB5 might play an important role in the regulation of oxidative stress by regulating the expression of SOD1 and Gpx1.	sodium arsenite	9-15	glutathione peroxidase 1	Homo sapiens	229-233
32201329-6	2020	In this study, we found that low-dose sodium arsenite (As (III)) repressed major airway mucins-MUC5AC and MUC5B at both mRNA and protein levels.	sodium arsenite	38-53	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	106-111
31669990-4	2020	In addition, NaAsO2 upregulated autophagy flux, elevated the level of cytoplasmic cathepsin B (CTSB), and activated the NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome in a subtle way.	sodium arsenite	13-19	cathepsin B	Rattus norvegicus	82-93
31587475-6	2020	SA similarly increased inflammatory reactions by increasing the level of interleukin-6, tumor necrosis factor-alpha, and interleukin-1beta.	sodium arsenite	0-2	interleukin 6	Homo sapiens	73-115
31587475-6	2020	SA similarly increased inflammatory reactions by increasing the level of interleukin-6, tumor necrosis factor-alpha, and interleukin-1beta.	sodium arsenite	0-2	interleukin 1 beta	Homo sapiens	121-138
31587475-7	2020	In addition, SA provoked the apoptosis by expanding the p53 and Bax levels, terminal deoxynucleotidyl transferase dUTP nick end labeling, and expression of caspase-3.	sodium arsenite	13-15	tumor protein p53	Homo sapiens	56-59
31587475-7	2020	In addition, SA provoked the apoptosis by expanding the p53 and Bax levels, terminal deoxynucleotidyl transferase dUTP nick end labeling, and expression of caspase-3.	sodium arsenite	13-15	BCL2 associated X, apoptosis regulator	Homo sapiens	64-67
31587475-7	2020	In addition, SA provoked the apoptosis by expanding the p53 and Bax levels, terminal deoxynucleotidyl transferase dUTP nick end labeling, and expression of caspase-3.	sodium arsenite	13-15	caspase 3	Homo sapiens	156-165
32001831-8	2020	Furthermore, prolonged nicotine exposure interferes with p53 function triggered by sodium arsenite.	sodium arsenite	83-98	tumor protein p53	Homo sapiens	57-60
31669990-4	2020	In addition, NaAsO2 upregulated autophagy flux, elevated the level of cytoplasmic cathepsin B (CTSB), and activated the NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome in a subtle way.	sodium arsenite	13-19	cathepsin B	Rattus norvegicus	95-99
31669990-4	2020	In addition, NaAsO2 upregulated autophagy flux, elevated the level of cytoplasmic cathepsin B (CTSB), and activated the NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome in a subtle way.	sodium arsenite	13-19	NLR family, pyrin domain containing 3	Rattus norvegicus	120-164
31669990-4	2020	In addition, NaAsO2 upregulated autophagy flux, elevated the level of cytoplasmic cathepsin B (CTSB), and activated the NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome in a subtle way.	sodium arsenite	13-19	NLR family, pyrin domain containing 3	Rattus norvegicus	166-171
31669990-5	2020	Consistent with these findings in vivo, we demonstrated that NaAsO2-induced activation of HSCs depended on CTSB-mediated NLRP3 inflammasome activation in HSC-t6 cells and rats primary HSCs.	sodium arsenite	61-67	cathepsin B	Rattus norvegicus	107-111
31669990-5	2020	Consistent with these findings in vivo, we demonstrated that NaAsO2-induced activation of HSCs depended on CTSB-mediated NLRP3 inflammasome activation in HSC-t6 cells and rats primary HSCs.	sodium arsenite	61-67	NLR family, pyrin domain containing 3	Rattus norvegicus	121-126
31669990-7	2020	In summary, these results indicated that NaAsO2 induced HSCs activation via autophagic-CTSB-NLRP3 inflammasome pathway.	sodium arsenite	41-47	cathepsin B	Rattus norvegicus	87-91
31669990-7	2020	In summary, these results indicated that NaAsO2 induced HSCs activation via autophagic-CTSB-NLRP3 inflammasome pathway.	sodium arsenite	41-47	NLR family, pyrin domain containing 3	Rattus norvegicus	92-97
31140275-6	2019	By employing a multiple-reaction monitoring (MRM)-based targeted proteomic method, we found that the protein level of RhoB was substantially decreased in IMR90 human lung fibroblast cells upon a 12-h exposure to 5 muM NaAsO2.	sodium arsenite	218-224	ras homolog family member B	Homo sapiens	118-122
31766100-6	2020	It alleviated sodium arsenite [As(III)]-induced intracellular oxidative stress in an Nrf2-dependent manner.	sodium arsenite	14-29	NFE2 like bZIP transcription factor 2	Homo sapiens	85-89
31771591-9	2019	Knockout of SPOP or expression of prostate cancer-associated SPOP mutants conferred resistance to death caused by SG inducers (e.g. docetaxel, sodium arsenite and H2O2) in prostate cancer cells.	sodium arsenite	143-158	speckle type BTB/POZ protein	Homo sapiens	12-16
31771591-9	2019	Knockout of SPOP or expression of prostate cancer-associated SPOP mutants conferred resistance to death caused by SG inducers (e.g. docetaxel, sodium arsenite and H2O2) in prostate cancer cells.	sodium arsenite	143-158	speckle type BTB/POZ protein	Homo sapiens	61-65
31272005-5	2019	We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation.	sodium arsenite	30-45	latexin	Homo sapiens	64-67
31272005-5	2019	We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation.	sodium arsenite	30-45	latexin	Homo sapiens	112-115
31272005-5	2019	We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation.	sodium arsenite	30-45	latexin	Homo sapiens	112-115
31272005-5	2019	We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation.	sodium arsenite	30-45	latexin	Homo sapiens	112-115
31272005-5	2019	We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation.	sodium arsenite	30-45	latexin	Homo sapiens	112-115
31272005-5	2019	We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation.	sodium arsenite	30-45	latexin	Homo sapiens	112-115
31272005-5	2019	We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation.	sodium arsenite	30-45	latexin	Homo sapiens	112-115
31029697-6	2019	The carcinogenic chemical stressor sodium arsenite caused the induction of HIPK2-dependent cell death and also resulted in a rapid and complete nuclear translocation of HIPK2, showing that the intracellular distribution of this kinase can undergo dynamic regulation.	sodium arsenite	35-50	homeodomain interacting protein kinase 2	Homo sapiens	75-80
31029697-6	2019	The carcinogenic chemical stressor sodium arsenite caused the induction of HIPK2-dependent cell death and also resulted in a rapid and complete nuclear translocation of HIPK2, showing that the intracellular distribution of this kinase can undergo dynamic regulation.	sodium arsenite	35-50	homeodomain interacting protein kinase 2	Homo sapiens	169-174
31146095-4	2019	Global m6A methylation levelsweremeasured in total RNA after exposuretotwo carcinogens (PM and sodium arsenite) for 24- and 48-h, and totwo endocrine disruptors (bisphenol A and vinclozolin)for 24-h.Global m6A methylation level significantly decreased with exposure to >62 mug/mlPM, >1 muM sodium arsenite, >1  muM bisphenol A (BPA), and0.1  muM vinclozolin.	sodium arsenite	95-110	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	7-10
31146095-4	2019	Global m6A methylation levelsweremeasured in total RNA after exposuretotwo carcinogens (PM and sodium arsenite) for 24- and 48-h, and totwo endocrine disruptors (bisphenol A and vinclozolin)for 24-h.Global m6A methylation level significantly decreased with exposure to >62 mug/mlPM, >1 muM sodium arsenite, >1  muM bisphenol A (BPA), and0.1  muM vinclozolin.	sodium arsenite	296-311	methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit	Homo sapiens	7-10
31216693-6	2019	SA activates the heme-regulated eIF2alpha (HRI) kinase, which phosphorylates eukaryotic translation initiation factor 2 alpha (eIF2alpha) to induce stress granule (SG) formation.	sodium arsenite	0-2	eukaryotic translation initiation factor 2A	Homo sapiens	77-125
31216693-6	2019	SA activates the heme-regulated eIF2alpha (HRI) kinase, which phosphorylates eukaryotic translation initiation factor 2 alpha (eIF2alpha) to induce stress granule (SG) formation.	sodium arsenite	0-2	eukaryotic translation initiation factor 2A	Homo sapiens	32-41
30898623-2	2019	Our present study found that during H2O2 or NaAsO2 induced injury of VSMC, the expression of miR-155-5p significantly increased.	sodium arsenite	44-50	microRNA 155	Homo sapiens	93-100
30898623-3	2019	While silencing of miR-155-5p can attenuate H2O2 or NaAsO2 suppressed viability and induced apoptosis of VSMCs.	sodium arsenite	52-58	microRNA 155	Homo sapiens	19-26
31199764-6	2019	Results Our evaluation revealed that 8 days of sodium arsenite (10 mg/kg body weight) treatment reduced the activities of the uterine enzymatic antioxidants superoxide dismutase, catalase, and peroxidase.	sodium arsenite	47-62	catalase	Rattus norvegicus	179-187
31075539-0	2019	DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress.	sodium arsenite	46-61	DISC1 scaffold protein	Homo sapiens	0-5
31075539-6	2019	DISC1 knockdown enhanced inhibition of protein synthesis in cells treated with sodium arsenite (SA), an oxidative agent used for studying stress granules (SGs) dynamics and translational control.	sodium arsenite	79-94	DISC1 scaffold protein	Homo sapiens	0-5
31075539-6	2019	DISC1 knockdown enhanced inhibition of protein synthesis in cells treated with sodium arsenite (SA), an oxidative agent used for studying stress granules (SGs) dynamics and translational control.	sodium arsenite	96-98	DISC1 scaffold protein	Homo sapiens	0-5
31075539-8	2019	DISC1 decreased SGs number in SA-treated cells, but resided outside SGs and maintained protein synthesis independently of a proper SG nucleation.	sodium arsenite	30-32	DISC1 scaffold protein	Homo sapiens	0-5
31075539-9	2019	DISC1-dependent stimulation of translation in SA-treated cells was supported by its interaction with eIF3h, a component of the canonical translation initiation machinery.	sodium arsenite	46-48	DISC1 scaffold protein	Homo sapiens	0-5
31075539-9	2019	DISC1-dependent stimulation of translation in SA-treated cells was supported by its interaction with eIF3h, a component of the canonical translation initiation machinery.	sodium arsenite	46-48	eukaryotic translation initiation factor 3 subunit H	Homo sapiens	101-106
31075539-10	2019	Consistent with a role in the homeostatic maintenance of translation, DISC1 knockdown or overexpression decreased cell viability after SA exposure.	sodium arsenite	135-137	DISC1 scaffold protein	Homo sapiens	70-75
31139082-6	2019	Moreover, Pts treatment further dramatically inhibited NaAsO2-induced apoptosis, specifically the mitochondrial mediation of apoptosis, which coincided with the effective recovery of NaAsO2-induced mitochondrial membrane potential (DeltaPsim) depolarization and cytochrome c release from the mitochondria.	sodium arsenite	55-61	cytochrome c, somatic	Homo sapiens	262-274
31139082-6	2019	Moreover, Pts treatment further dramatically inhibited NaAsO2-induced apoptosis, specifically the mitochondrial mediation of apoptosis, which coincided with the effective recovery of NaAsO2-induced mitochondrial membrane potential (DeltaPsim) depolarization and cytochrome c release from the mitochondria.	sodium arsenite	183-189	cytochrome c, somatic	Homo sapiens	262-274
31139082-9	2019	In addition, the effects of Pts on NaAsO2-induced cell viability were largely weakened when Nrf2 was knocked down.	sodium arsenite	35-41	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
31050222-3	2019	Specifically, oxidative stress induced in a human recombinant TDP-43- or FUS-tGFP U2OS cell line by exposure to sodium arsenite was shown to be significantly reduced by our collection of molecules using in vitro imaging of FUS and TDP-43 stress granules.	sodium arsenite	112-127	TAR DNA binding protein	Homo sapiens	62-68
31322264-10	2019	The data indicated that WIF1 gene expression was decreased by sodium arsenite, whereas this was not noted for CBS, MALAT1 and ADORA1.	sodium arsenite	62-77	WNT inhibitory factor 1	Homo sapiens	24-28
31322264-11	2019	Sodium arsenite decreased mRNA and protein expression levels of the WIF1 gene.	sodium arsenite	0-15	WNT inhibitory factor 1	Homo sapiens	68-72
31322264-15	2019	In summary, the data indicated that sodium arsenite decreased WIF1 gene expression and promoted cell migration.	sodium arsenite	36-51	WNT inhibitory factor 1	Homo sapiens	62-66
31050222-3	2019	Specifically, oxidative stress induced in a human recombinant TDP-43- or FUS-tGFP U2OS cell line by exposure to sodium arsenite was shown to be significantly reduced by our collection of molecules using in vitro imaging of FUS and TDP-43 stress granules.	sodium arsenite	112-127	FUS RNA binding protein	Homo sapiens	73-76
31050222-3	2019	Specifically, oxidative stress induced in a human recombinant TDP-43- or FUS-tGFP U2OS cell line by exposure to sodium arsenite was shown to be significantly reduced by our collection of molecules using in vitro imaging of FUS and TDP-43 stress granules.	sodium arsenite	112-127	FUS RNA binding protein	Homo sapiens	223-226
31050222-3	2019	Specifically, oxidative stress induced in a human recombinant TDP-43- or FUS-tGFP U2OS cell line by exposure to sodium arsenite was shown to be significantly reduced by our collection of molecules using in vitro imaging of FUS and TDP-43 stress granules.	sodium arsenite	112-127	TAR DNA binding protein	Homo sapiens	231-237
30721701-9	2019	Activation of p38MAPK, by Sodium Arsenite or Anisomycin, mimicked the inhibitory effect of Sildenafil on the exchanger.	sodium arsenite	26-41	mitogen activated protein kinase 14	Rattus norvegicus	14-21
31065237-3	2019	Further, we have investigated the effect of NaAsO2 on the androgen receptor.	sodium arsenite	44-50	androgen receptor	Homo sapiens	58-75
30796345-3	2019	We found that similarly to canonical Hsps, Arc/Arg3.1 is also markedly induced by heat shock and by other cellular stress inducers, including diamide, sodium arsenite and H2O2 in various cells.	sodium arsenite	151-166	activity regulated cytoskeleton associated protein	Homo sapiens	43-53
30773942-5	2019	Moreover, NOR protected human lung epithelial Beas-2B cells against sodium arsenite [As(III)]-induced cytotoxicity in an Nrf2-dependent manner.	sodium arsenite	68-83	NFE2 like bZIP transcription factor 2	Homo sapiens	121-125
30664189-4	2019	In this study, we examined the effects of sodium arsenite (NaAsIII) exposure in ERalpha-positive breast cancer cells in vitro and in mammary tumor xenografts.	sodium arsenite	42-57	estrogen receptor 1	Homo sapiens	80-87
31353640-1	2019	In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats.	sodium arsenite	59-74	aldo-keto reductase family 1 member B1	Rattus norvegicus	201-203
31353640-1	2019	In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats.	sodium arsenite	59-74	paraoxonase 1	Rattus norvegicus	221-225
31353640-1	2019	In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats.	sodium arsenite	59-74	butyrylcholinesterase	Rattus norvegicus	259-282
31353640-1	2019	In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats.	sodium arsenite	59-74	butyrylcholinesterase	Rattus norvegicus	284-288
31353640-1	2019	In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats.	sodium arsenite	76-78	paraoxonase 1	Rattus norvegicus	206-219
31353640-1	2019	In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats.	sodium arsenite	76-78	paraoxonase 1	Rattus norvegicus	221-225
31353640-1	2019	In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats.	sodium arsenite	76-78	butyrylcholinesterase	Rattus norvegicus	259-282
31353640-1	2019	In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats.	sodium arsenite	76-78	butyrylcholinesterase	Rattus norvegicus	284-288
31353640-6	2019	PON1 enzyme activity was increased significantly in kidney and liver tissues of rats HSP groups and decreased SA groups compared to control.	sodium arsenite	110-112	paraoxonase 1	Rattus norvegicus	0-4
30408888-9	2019	To study the underlying mechanism of arsenic-induced apoptosis, we exposed PEDF-transfected PC12 cells to NaAsO2.	sodium arsenite	106-112	serpin family F member 1	Rattus norvegicus	75-79
30408888-10	2019	We discovered that NaAsO2--induced mitochondrial apoptosis was enhanced in cells that over expressed PEDF.	sodium arsenite	19-25	serpin family F member 1	Rattus norvegicus	101-105
31553994-4	2019	SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species.	sodium arsenite	0-2	fibronectin 1	Mus musculus	66-77
31553994-4	2019	SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species.	sodium arsenite	0-2	fibronectin 1	Mus musculus	79-81
31553994-4	2019	SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species.	sodium arsenite	0-2	transforming growth factor, beta 1	Mus musculus	97-105
31553994-4	2019	SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species.	sodium arsenite	0-2	transforming growth factor, beta 1	Mus musculus	142-150
31553994-4	2019	SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species.	sodium arsenite	0-2	NADPH oxidase 4	Mus musculus	176-191
31553994-4	2019	SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species.	sodium arsenite	125-127	transforming growth factor, beta 1	Mus musculus	142-150
31553994-4	2019	SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species.	sodium arsenite	125-127	NADPH oxidase 4	Mus musculus	176-191
31553994-5	2019	TGF-beta-induced the phosphorylation of ERK and Smad3 were also blocked by SA.	sodium arsenite	75-77	transforming growth factor, beta 1	Mus musculus	0-8
31553994-5	2019	TGF-beta-induced the phosphorylation of ERK and Smad3 were also blocked by SA.	sodium arsenite	75-77	mitogen-activated protein kinase 1	Mus musculus	40-43
31553994-5	2019	TGF-beta-induced the phosphorylation of ERK and Smad3 were also blocked by SA.	sodium arsenite	75-77	SMAD family member 3	Mus musculus	48-53
31553994-6	2019	The administration of SA (IP) suppressed BLM-induced lung fibrosis characterized as the inhibition of collagen deposition, TGF-beta accumulation in bronchoalveolar lavage fluid, and the expression of FN and collagen 1a2 in lung tissue.	sodium arsenite	22-24	transforming growth factor, beta 1	Mus musculus	123-131
31553994-6	2019	The administration of SA (IP) suppressed BLM-induced lung fibrosis characterized as the inhibition of collagen deposition, TGF-beta accumulation in bronchoalveolar lavage fluid, and the expression of FN and collagen 1a2 in lung tissue.	sodium arsenite	22-24	fibronectin 1	Mus musculus	200-202
31553994-7	2019	This study revealed that SA inhibits TGF-beta-induced lung fibroblast differentiation and BLM-induced pulmonary fibrosis in mice, suggesting that SA could be a potential therapeutic approach to IPF.	sodium arsenite	25-27	transforming growth factor, beta 1	Mus musculus	37-45
31553994-7	2019	This study revealed that SA inhibits TGF-beta-induced lung fibroblast differentiation and BLM-induced pulmonary fibrosis in mice, suggesting that SA could be a potential therapeutic approach to IPF.	sodium arsenite	146-148	transforming growth factor, beta 1	Mus musculus	37-45
29864498-7	2018	Sodium arsenite induced Fas and Bax mRNA expression, then MMA and DMA did not induce mRNA expression in MDA-MB-231 and XWLC-05 cells.	sodium arsenite	0-15	BCL2 associated X, apoptosis regulator	Homo sapiens	32-35
30622953-0	2018	Corrigendum #2 to "Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats".	sodium arsenite	50-65	vascular endothelial growth factor A	Rattus norvegicus	84-88
30622953-0	2018	Corrigendum #2 to "Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats".	sodium arsenite	50-65	kinase insert domain receptor	Rattus norvegicus	93-99
30130555-0	2018	Sodium arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in mouse embryonic fibroblast cells.	sodium arsenite	0-15	E1A binding protein p300	Mus musculus	60-64
30278242-0	2018	Metabolism and disposition of arsenic species from controlled dosing with sodium arsenite in adult female CD-1 mice.	sodium arsenite	74-89	CD1 antigen complex	Mus musculus	106-110
30227999-6	2018	Further studies indicated that 7-MBA activated Nrf2 signaling pathway and protected human lung epithelial Beas-2B cells against sodium arsenite [As(III)]-induced cytotoxicity in an Nrf2-dependent manner.	sodium arsenite	128-143	NFE2 like bZIP transcription factor 2	Homo sapiens	181-185
29945972-5	2018	Here, using a range of human and murine cells, we show that TFEB and TFE3 are activated upon induction of acute oxidative stress by sodium arsenite via an mTOR complex 1 (mTORC1)-independent process.	sodium arsenite	132-147	transcription factor EB	Mus musculus	60-64
29945972-5	2018	Here, using a range of human and murine cells, we show that TFEB and TFE3 are activated upon induction of acute oxidative stress by sodium arsenite via an mTOR complex 1 (mTORC1)-independent process.	sodium arsenite	132-147	transcription factor E3	Mus musculus	69-73
29945972-5	2018	Here, using a range of human and murine cells, we show that TFEB and TFE3 are activated upon induction of acute oxidative stress by sodium arsenite via an mTOR complex 1 (mTORC1)-independent process.	sodium arsenite	132-147	CREB regulated transcription coactivator 1	Mus musculus	171-177
29945972-7	2018	Depletion of either the catalytic (PPP2CA+B) or regulatory (PPP2R2A/B55alpha) subunits of PP2A, as well as PP2A inactivation with the specific inhibitor okadaic acid, abolished TFEB and TFE3 activation in response to sodium arsenite.	sodium arsenite	217-232	protein phosphatase 2 phosphatase activator	Homo sapiens	90-94
29864931-7	2018	Furthermore, SA enhanced levels of malondialdehyde, tumor necrosis factor-alpha, interleukin-1beta and nitric oxide in testes.	sodium arsenite	13-15	tumor necrosis factor	Rattus norvegicus	52-79
29383632-9	2018	The results indicate that SA-intoxicated rats display significantly higher levels of plasma cardiac markers (AST, CK-MB, LDH and cTnI) than normal control animals.	sodium arsenite	26-28	troponin I3, cardiac type	Rattus norvegicus	129-133
29383632-11	2018	Furthermore, SA-treated rats showed significantly lower WBC, RBC, HGB, HCT and PLT and significantly higher MCV and MCH.	sodium arsenite	13-15	oleoyl-ACP hydrolase	Rattus norvegicus	116-119
29864931-7	2018	Furthermore, SA enhanced levels of malondialdehyde, tumor necrosis factor-alpha, interleukin-1beta and nitric oxide in testes.	sodium arsenite	13-15	interleukin 1 beta	Rattus norvegicus	81-98
29854073-4	2018	Significant activation of MAPK, NF-kappaB, p53, and intrinsic and extrinsic apoptotic signaling was observed in NaAsO2-exposed hepatic cells.	sodium arsenite	112-118	transformation related protein 53, pseudogene	Mus musculus	43-46
29630858-0	2018	Antioxidant supplementation upregulates calbindin expression in cerebellar Purkinje cells of rat pups subjected to post natal exposure to sodium arsenite.	sodium arsenite	138-153	calbindin 1	Rattus norvegicus	40-49
29630858-4	2018	The present study focused on determining the strategies that would modulate tissue redox status and calcium binding protein (CaBP) (Calbindin D28k-CB) expression affected adversely by sodium arsenite (NaAsO2) exposure (postnatal) of rat pups.	sodium arsenite	184-199	hippocalcin	Rattus norvegicus	100-123
29630858-4	2018	The present study focused on determining the strategies that would modulate tissue redox status and calcium binding protein (CaBP) (Calbindin D28k-CB) expression affected adversely by sodium arsenite (NaAsO2) exposure (postnatal) of rat pups.	sodium arsenite	184-199	hippocalcin	Rattus norvegicus	125-129
29630858-4	2018	The present study focused on determining the strategies that would modulate tissue redox status and calcium binding protein (CaBP) (Calbindin D28k-CB) expression affected adversely by sodium arsenite (NaAsO2) exposure (postnatal) of rat pups.	sodium arsenite	184-199	calbindin 1	Rattus norvegicus	132-141
29630858-4	2018	The present study focused on determining the strategies that would modulate tissue redox status and calcium binding protein (CaBP) (Calbindin D28k-CB) expression affected adversely by sodium arsenite (NaAsO2) exposure (postnatal) of rat pups.	sodium arsenite	201-207	hippocalcin	Rattus norvegicus	100-123
29630858-4	2018	The present study focused on determining the strategies that would modulate tissue redox status and calcium binding protein (CaBP) (Calbindin D28k-CB) expression affected adversely by sodium arsenite (NaAsO2) exposure (postnatal) of rat pups.	sodium arsenite	201-207	hippocalcin	Rattus norvegicus	125-129
29630858-4	2018	The present study focused on determining the strategies that would modulate tissue redox status and calcium binding protein (CaBP) (Calbindin D28k-CB) expression affected adversely by sodium arsenite (NaAsO2) exposure (postnatal) of rat pups.	sodium arsenite	201-207	calbindin 1	Rattus norvegicus	132-141
29630858-10	2018	The observations are suggestive of AOX induced restoration of CaBP expression in rat cerebellum following early postnatal exposure to NaAsO2.	sodium arsenite	134-140	acyl-CoA oxidase 1	Rattus norvegicus	35-38
29630858-10	2018	The observations are suggestive of AOX induced restoration of CaBP expression in rat cerebellum following early postnatal exposure to NaAsO2.	sodium arsenite	134-140	hippocalcin	Rattus norvegicus	62-66
29723552-5	2018	Treatment with curcumin ameliorated sodium arsenite induced alterations in the levels of NMDA receptors, its receptor subunits and synaptic proteins - pCaMKIIalpha, PSD-95 and SynGAP both in vivo and in vitro.	sodium arsenite	36-51	discs large MAGUK scaffold protein 4	Rattus norvegicus	165-171
29723552-5	2018	Treatment with curcumin ameliorated sodium arsenite induced alterations in the levels of NMDA receptors, its receptor subunits and synaptic proteins - pCaMKIIalpha, PSD-95 and SynGAP both in vivo and in vitro.	sodium arsenite	36-51	synaptic Ras GTPase activating protein 1	Rattus norvegicus	176-182
29723552-6	2018	Decreased levels of BDNF, pAkt, pERK1/2, pGSK3beta and pCREB on sodium arsenite exposure were also protected by curcumin.	sodium arsenite	64-79	brain-derived neurotrophic factor	Rattus norvegicus	20-24
29723552-7	2018	Curcumin was found to decrease sodium arsenite induced changes in hippocampus by modulating PI3K/Akt/GSK3beta neuronal survival pathway, known to regulate various cellular events.	sodium arsenite	31-46	AKT serine/threonine kinase 1	Rattus norvegicus	97-100
29723552-7	2018	Curcumin was found to decrease sodium arsenite induced changes in hippocampus by modulating PI3K/Akt/GSK3beta neuronal survival pathway, known to regulate various cellular events.	sodium arsenite	31-46	glycogen synthase kinase 3 beta	Rattus norvegicus	101-109
29725571-10	2018	GSTO1 mutant genotypes were found to have significant higher genotoxicity of sodium arsenite as compared to wild-type genotype.	sodium arsenite	77-92	glutathione S-transferase omega 1	Homo sapiens	0-5
29725571-12	2018	A significant effect of GSTO1 polymorphism was observed on genotoxicity of sodium arsenite.	sodium arsenite	75-90	glutathione S-transferase omega 1	Homo sapiens	24-29
29111283-6	2018	After treatment with NaAsO2, the p-PERK level in INS-1 rat pancreatic beta- cells was increased correspondingly.	sodium arsenite	21-27	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	35-39
29204679-5	2018	In CD-1 mice gestationally exposed to 20 ppm of sodium arsenite in drinking water, we have previously observed up-regulation of xCT in the male mouse hippocampus which caused glutamatergic synapse alterations affecting learning and memory processes.	sodium arsenite	48-63	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	128-131
29511641-6	2018	Rats fed with sodium arsenite exhibited a significant lessening in the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx).	sodium arsenite	14-29	catalase	Rattus norvegicus	113-121
29526746-4	2018	Here we showed that NaAsO2 caused significant reduction in basal levels of glucose, plasma membrane glucose transporter, GLUT 3 and Akt phosphorylation in differentiated human neuroblastoma SH-SY5Y cells.	sodium arsenite	20-26	solute carrier family 2 member 3	Homo sapiens	121-127
29526746-4	2018	Here we showed that NaAsO2 caused significant reduction in basal levels of glucose, plasma membrane glucose transporter, GLUT 3 and Akt phosphorylation in differentiated human neuroblastoma SH-SY5Y cells.	sodium arsenite	20-26	AKT serine/threonine kinase 1	Homo sapiens	132-135
29526746-5	2018	NaAsO2 significantly decreased insulin-mediated glucose uptake, as well as GLUT1 and 3 membrane translocation.	sodium arsenite	0-6	insulin	Homo sapiens	31-38
29526746-6	2018	Furthermore, the ability of insulin to increase Akt phosphorylation, a well-recognized insulin signaling response, was significantly lessened by NaAsO2 treatment.	sodium arsenite	145-151	insulin	Homo sapiens	28-35
29526746-6	2018	Furthermore, the ability of insulin to increase Akt phosphorylation, a well-recognized insulin signaling response, was significantly lessened by NaAsO2 treatment.	sodium arsenite	145-151	AKT serine/threonine kinase 1	Homo sapiens	48-51
29526746-6	2018	Furthermore, the ability of insulin to increase Akt phosphorylation, a well-recognized insulin signaling response, was significantly lessened by NaAsO2 treatment.	sodium arsenite	145-151	insulin	Homo sapiens	87-94
29526746-7	2018	In addition, the classical tyrosine phosphorylation response of insulin was reduced by NaAsO2, as evidenced by reduction of insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1(IRS-1).	sodium arsenite	87-93	insulin	Homo sapiens	64-71
29526746-7	2018	In addition, the classical tyrosine phosphorylation response of insulin was reduced by NaAsO2, as evidenced by reduction of insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1(IRS-1).	sodium arsenite	87-93	insulin	Homo sapiens	124-131
29526746-7	2018	In addition, the classical tyrosine phosphorylation response of insulin was reduced by NaAsO2, as evidenced by reduction of insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1(IRS-1).	sodium arsenite	87-93	insulin	Homo sapiens	124-131
29526746-7	2018	In addition, the classical tyrosine phosphorylation response of insulin was reduced by NaAsO2, as evidenced by reduction of insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1(IRS-1).	sodium arsenite	87-93	insulin	Homo sapiens	124-131
29526746-7	2018	In addition, the classical tyrosine phosphorylation response of insulin was reduced by NaAsO2, as evidenced by reduction of insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1(IRS-1).	sodium arsenite	87-93	insulin receptor substrate 1	Homo sapiens	223-228
29526746-8	2018	Moreover, NaAsO2 lowered the ratio of p110, a catalytic subunit to p85, a regulatory subunit of PI3K causing an imbalance between p110 and p85, the conditions reported to contribute to insulin sensitivity.	sodium arsenite	10-16	endogenous retrovirus group K member 15	Homo sapiens	38-42
29526746-8	2018	Moreover, NaAsO2 lowered the ratio of p110, a catalytic subunit to p85, a regulatory subunit of PI3K causing an imbalance between p110 and p85, the conditions reported to contribute to insulin sensitivity.	sodium arsenite	10-16	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	67-70
29526746-8	2018	Moreover, NaAsO2 lowered the ratio of p110, a catalytic subunit to p85, a regulatory subunit of PI3K causing an imbalance between p110 and p85, the conditions reported to contribute to insulin sensitivity.	sodium arsenite	10-16	endogenous retrovirus group K member 15	Homo sapiens	130-134
29526746-8	2018	Moreover, NaAsO2 lowered the ratio of p110, a catalytic subunit to p85, a regulatory subunit of PI3K causing an imbalance between p110 and p85, the conditions reported to contribute to insulin sensitivity.	sodium arsenite	10-16	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	139-142
29526746-8	2018	Moreover, NaAsO2 lowered the ratio of p110, a catalytic subunit to p85, a regulatory subunit of PI3K causing an imbalance between p110 and p85, the conditions reported to contribute to insulin sensitivity.	sodium arsenite	10-16	insulin	Homo sapiens	185-192
29526746-9	2018	Additionally, increment of IRS-1 interaction with GSK3beta, and p85-PI3K were observed in NaAsO2 treated cells.	sodium arsenite	90-96	insulin receptor substrate 1	Homo sapiens	27-32
29526746-9	2018	Additionally, increment of IRS-1 interaction with GSK3beta, and p85-PI3K were observed in NaAsO2 treated cells.	sodium arsenite	90-96	glycogen synthase kinase 3 beta	Homo sapiens	50-58
29526746-9	2018	Additionally, increment of IRS-1 interaction with GSK3beta, and p85-PI3K were observed in NaAsO2 treated cells.	sodium arsenite	90-96	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	64-67
29111283-6	2018	After treatment with NaAsO2, the p-PERK level in INS-1 rat pancreatic beta- cells was increased correspondingly.	sodium arsenite	21-27	insulin 1	Rattus norvegicus	49-54
29111283-9	2018	In NaAsO2-treated INS-1 cells, the initiation of ER stress preceded the stimulation of autophagy, which was a key factor controlling pancreatic beta cell function.	sodium arsenite	3-9	insulin 1	Rattus norvegicus	18-23
29479036-6	2018	Moreover, the combination prolonged the phosphorylation of mitogen-activated protein kinase (MAPK) members, including c-Jun-N-terminal kinase (JNK), p38, and extracellular signal related kinases (ERK), and increased intracellular reactive oxygen species (ROS), in comparison to treatment of NaAsO2 or TNF-alpha alone.	sodium arsenite	291-297	mitogen-activated protein kinase 1	Homo sapiens	93-97
29111283-10	2018	Furthermore, knockdown of PERK attenuated NaAsO2-induced autophagy in INS-1 cells.	sodium arsenite	42-48	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	26-30
29111283-10	2018	Furthermore, knockdown of PERK attenuated NaAsO2-induced autophagy in INS-1 cells.	sodium arsenite	42-48	insulin 1	Rattus norvegicus	70-75
29479036-11	2018	In conclusion, NaAsO2 exposure might amplify inflammation-related tissue injury by potentiating the apoptosis-inducing effect of TNF-alpha through ROS-dependent mechanism.	sodium arsenite	15-21	tumor necrosis factor	Homo sapiens	129-138
29479036-3	2018	The effects of excess NaAsO2 on TNF-alpha response and its intracellular signaling are not well understood.	sodium arsenite	22-28	tumor necrosis factor	Homo sapiens	32-41
29479036-4	2018	We hypothesized that NaAsO2 exposure might affect cellular response to TNF-alpha.	sodium arsenite	21-27	tumor necrosis factor	Homo sapiens	71-80
29233969-4	2017	When neurons are stressed such as by heat shock or sodium arsenite (As), cells engage specific proteosome-mediated degradation to reduce RIP140 level, thereby relieving the suppression and activating HSR.	sodium arsenite	51-66	nuclear receptor interacting protein 1	Mus musculus	137-143
29479036-5	2018	Using HeLa cell model, we found that the combination of NaAsO2 and TNF-alpha clearly decreased cell viability and mitochondrial membrane potential, but increased percentage of early and late apoptotic cells and cleaved-poly (ADP-ribose) polymerase (PARP).	sodium arsenite	56-62	poly(ADP-ribose) polymerase 1	Homo sapiens	219-247
29479036-5	2018	Using HeLa cell model, we found that the combination of NaAsO2 and TNF-alpha clearly decreased cell viability and mitochondrial membrane potential, but increased percentage of early and late apoptotic cells and cleaved-poly (ADP-ribose) polymerase (PARP).	sodium arsenite	56-62	poly(ADP-ribose) polymerase 1	Homo sapiens	249-253
29657918-8	2017	Histopathology and immunohistochemistry revealed varying degrees of recovery in hepatocyte ultrastructure alongside increased expression of the pro-survival protein Kinase B (Akt/PKB) after 4 weeks of NaAsO2 withdrawal.	sodium arsenite	201-207	AKT serine/threonine kinase 1	Rattus norvegicus	175-182
28771313-4	2017	The biodisplay detected 10 mug/L sodium-arsenite in tap water using a research grade fluorescent microscope, and reported arsenic contamination down to 20 mug/L with an easy to interpret "skull and crossbones" symbol detectable with a low-cost USB microscope or by eye.	sodium arsenite	33-48	nuclear RNA export factor 1	Homo sapiens	52-55
28366046-0	2017	Sodium arsenite-induced cardiovascular and renal dysfunction in rat via oxidative stress and protein kinase B (Akt/PKB) signaling pathway.	sodium arsenite	0-15	AKT serine/threonine kinase 1	Rattus norvegicus	111-118
28974440-0	2017	Hijiki and sodium arsenite stimulate growth of human colorectal adenocarcinoma cells through ERK1/2 activation.	sodium arsenite	11-26	mitogen-activated protein kinase 3	Homo sapiens	93-99
28974440-6	2017	Hijiki and sodium arsenite induced epidermal growth factor receptor (EGFR) and ERK1/2 activations.	sodium arsenite	11-26	epidermal growth factor receptor	Homo sapiens	35-67
28974440-6	2017	Hijiki and sodium arsenite induced epidermal growth factor receptor (EGFR) and ERK1/2 activations.	sodium arsenite	11-26	epidermal growth factor receptor	Homo sapiens	69-73
28974440-6	2017	Hijiki and sodium arsenite induced epidermal growth factor receptor (EGFR) and ERK1/2 activations.	sodium arsenite	11-26	mitogen-activated protein kinase 3	Homo sapiens	79-85
28974440-7	2017	AG1478, an EGFR inhibitor, decreased the activation of EGFR and ERK1/2 induced by Hijiki and sodium arsenite.	sodium arsenite	93-108	epidermal growth factor receptor	Homo sapiens	11-15
28974440-7	2017	AG1478, an EGFR inhibitor, decreased the activation of EGFR and ERK1/2 induced by Hijiki and sodium arsenite.	sodium arsenite	93-108	epidermal growth factor receptor	Homo sapiens	55-59
28974440-7	2017	AG1478, an EGFR inhibitor, decreased the activation of EGFR and ERK1/2 induced by Hijiki and sodium arsenite.	sodium arsenite	93-108	mitogen-activated protein kinase 3	Homo sapiens	64-70
28843991-5	2017	Acute oral administration of NaAsO2 also raised pulmonary MPO activity and mRNA levels of chemokine Mip-2 and Mcp-1.	sodium arsenite	29-35	chemokine (C-X-C motif) ligand 2	Mus musculus	100-105
28843991-5	2017	Acute oral administration of NaAsO2 also raised pulmonary MPO activity and mRNA levels of chemokine Mip-2 and Mcp-1.	sodium arsenite	29-35	mast cell protease 1	Mus musculus	110-115
29044176-6	2017	Validation by western blot showed increased level of clathrin-associated sorting protein Disabled 2 (Dab2) in NaAsO2 group, indicating that it may regulate receptor endocytosis, which served as a mechanism to augment intracellular VEGF signaling.	sodium arsenite	110-116	disabled 2, mitogen-responsive phosphoprotein	Mus musculus	89-99
29044176-6	2017	Validation by western blot showed increased level of clathrin-associated sorting protein Disabled 2 (Dab2) in NaAsO2 group, indicating that it may regulate receptor endocytosis, which served as a mechanism to augment intracellular VEGF signaling.	sodium arsenite	110-116	disabled 2, mitogen-responsive phosphoprotein	Mus musculus	101-105
29044176-6	2017	Validation by western blot showed increased level of clathrin-associated sorting protein Disabled 2 (Dab2) in NaAsO2 group, indicating that it may regulate receptor endocytosis, which served as a mechanism to augment intracellular VEGF signaling.	sodium arsenite	110-116	vascular endothelial growth factor A	Mus musculus	231-235
28744533-9	2017	The experimental results show that TH287 is likely to inhibit MTH1 in tumor cells, rendering them more sensitive to NaAsO2.	sodium arsenite	116-122	nudix hydrolase 1	Homo sapiens	62-66
28936164-6	2017	Moreover, sodium arsenite triggered unfolded protein response (UPR), leading to the phosphorylation of RNA-regulated protein kinase-like ER kinase (PERK) and eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha), and the induction of activating transcription factor 4 (ATF4).	sodium arsenite	10-25	eukaryotic translation initiation factor 2 subunit alpha	Rattus norvegicus	158-214
28936164-6	2017	Moreover, sodium arsenite triggered unfolded protein response (UPR), leading to the phosphorylation of RNA-regulated protein kinase-like ER kinase (PERK) and eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha), and the induction of activating transcription factor 4 (ATF4).	sodium arsenite	10-25	eukaryotic translation initiation factor 2A	Rattus norvegicus	216-225
28936164-6	2017	Moreover, sodium arsenite triggered unfolded protein response (UPR), leading to the phosphorylation of RNA-regulated protein kinase-like ER kinase (PERK) and eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha), and the induction of activating transcription factor 4 (ATF4).	sodium arsenite	10-25	activating transcription factor 4	Rattus norvegicus	249-282
28936164-6	2017	Moreover, sodium arsenite triggered unfolded protein response (UPR), leading to the phosphorylation of RNA-regulated protein kinase-like ER kinase (PERK) and eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha), and the induction of activating transcription factor 4 (ATF4).	sodium arsenite	10-25	activating transcription factor 4	Rattus norvegicus	284-288
27685703-6	2017	In vitro studies revealed an induction of ERCC2 hypermethylation and decreased mRNA expression in response to NaAsO2 treatment.	sodium arsenite	110-116	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	42-47
28746394-5	2017	Moreover, we showed that SA and HS, but not H2O2, promote eIF2alpha phosphorylation in hiPSCs forming SGs.	sodium arsenite	25-27	eukaryotic translation initiation factor 2A	Homo sapiens	58-67
28715409-6	2017	We demonstrate that ZIKV negatively impacts SG assembly under oxidative stress conditions induced by sodium arsenite (Ars), a treatment that leads to the phosphorylation of eIF2alpha.	sodium arsenite	101-116	eukaryotic translation initiation factor 2A	Homo sapiens	173-182
28347842-3	2017	We examined the involvement of heme metabolism in the induction of HO-1 by the inducers sulforaphane and sodium arsenite.	sodium arsenite	105-120	heme oxygenase 1	Homo sapiens	67-71
28347842-4	2017	METHODS: We examined the expression of HO-1 in sulforaphane-, sodium arsenite- and CORM3-treated HEK293T cells, by measuring the transcriptional activity and levels of mRNA and protein.	sodium arsenite	62-77	heme oxygenase 1	Homo sapiens	39-43
28726208-3	2017	Heme oxygenase 1, an inducible form of the enzyme, is normally not expressed in the cerebral vessels, but the enzyme is expressed in response to sodium metaarsenite.	sodium arsenite	145-164	heme oxygenase 1	Rattus norvegicus	0-16
28495450-4	2017	Secondly, in response to in vitro cellular stress (500muM sodium arsenite for 1h; or 400mM sorbitol 1 hour exposure; as an oxidative or osmotic stress, respectively), we observed a significant survival benefit in RGNEF-transfected HEK293T cells.	sodium arsenite	58-73	Rho guanine nucleotide exchange factor 28	Homo sapiens	213-218
28556958-0	2017	Downregulation of androgen receptors by NaAsO2 via inhibition of AKT-NF-kappaB and HSP90 in castration resistant prostate cancer.	sodium arsenite	40-46	AKT serine/threonine kinase 1	Homo sapiens	65-68
28556958-0	2017	Downregulation of androgen receptors by NaAsO2 via inhibition of AKT-NF-kappaB and HSP90 in castration resistant prostate cancer.	sodium arsenite	40-46	nuclear factor kappa B subunit 1	Homo sapiens	69-78
28556958-0	2017	Downregulation of androgen receptors by NaAsO2 via inhibition of AKT-NF-kappaB and HSP90 in castration resistant prostate cancer.	sodium arsenite	40-46	heat shock protein 90 alpha family class A member 1	Homo sapiens	83-88
28556958-5	2017	The aim of this study was to examine the effect of NaAsO2 on AR signaling in LNCaP and 22Rv1 CRPC cells.	sodium arsenite	51-57	androgen receptor	Homo sapiens	61-63
28556958-9	2017	RESULTS: NaAsO2 significantly reduced the translocation of AR and AR-Vs to the nucleus as well as their level in LNCaP and 22Rv1 cells.	sodium arsenite	9-15	androgen receptor	Homo sapiens	59-61
28556958-12	2017	NaAsO2 significantly inhibited phosphorylation of AKT and expression and nuclear translocation of NF-kappaB.	sodium arsenite	0-6	AKT serine/threonine kinase 1	Homo sapiens	50-53
28556958-12	2017	NaAsO2 significantly inhibited phosphorylation of AKT and expression and nuclear translocation of NF-kappaB.	sodium arsenite	0-6	nuclear factor kappa B subunit 1	Homo sapiens	98-107
28556958-14	2017	NaAsO2 promoted HSP90 acetylation by down-regulating HDAC6, which reduces the stability of AR in prostate cancer cells.	sodium arsenite	0-6	heat shock protein 90 alpha family class A member 1	Homo sapiens	16-21
28556958-14	2017	NaAsO2 promoted HSP90 acetylation by down-regulating HDAC6, which reduces the stability of AR in prostate cancer cells.	sodium arsenite	0-6	histone deacetylase 6	Homo sapiens	53-58
28556958-14	2017	NaAsO2 promoted HSP90 acetylation by down-regulating HDAC6, which reduces the stability of AR in prostate cancer cells.	sodium arsenite	0-6	androgen receptor	Homo sapiens	91-93
28556958-15	2017	CONCLUSIONS: Here, we show that NaAsO2 disrupts AR signaling at multiple levels by affecting AR expression, stability, and degradation in primary tumor cell cultures from prostate cancer patients as well as CRPC cell lines.	sodium arsenite	32-38	androgen receptor	Homo sapiens	48-50
28556958-15	2017	CONCLUSIONS: Here, we show that NaAsO2 disrupts AR signaling at multiple levels by affecting AR expression, stability, and degradation in primary tumor cell cultures from prostate cancer patients as well as CRPC cell lines.	sodium arsenite	32-38	androgen receptor	Homo sapiens	93-95
29029432-0	2017	The involvement of Nrf2 in the protective effects of (-)-Epigallocatechin-3-gallate (EGCG) on NaAsO2-induced hepatotoxicity.	sodium arsenite	94-100	NFE2 like bZIP transcription factor 2	Homo sapiens	19-23
28225195-2	2017	Rats exposed to sodium arsenite (25 ppm for 8 weeks) showed decreased mitochondrial complexes (I, II, IV) activities, mitochondrial superoxide dismutase (MnSOD), and catalase activities in brain mitochondria.	sodium arsenite	16-31	superoxide dismutase 2	Rattus norvegicus	118-152
28225195-2	2017	Rats exposed to sodium arsenite (25 ppm for 8 weeks) showed decreased mitochondrial complexes (I, II, IV) activities, mitochondrial superoxide dismutase (MnSOD), and catalase activities in brain mitochondria.	sodium arsenite	16-31	superoxide dismutase 2	Rattus norvegicus	154-159
28225195-2	2017	Rats exposed to sodium arsenite (25 ppm for 8 weeks) showed decreased mitochondrial complexes (I, II, IV) activities, mitochondrial superoxide dismutase (MnSOD), and catalase activities in brain mitochondria.	sodium arsenite	16-31	catalase	Rattus norvegicus	166-174
28726208-5	2017	Sodium meta-arsenite is inessential for immunolocation and quantitative distribution of heme oxygenase 2 in the vessels.	sodium arsenite	0-20	heme oxygenase 2	Rattus norvegicus	88-104
28229933-5	2017	We investigated the activation of nuclear factor-E2-related factor 2 (Nrf2) which regulates various antioxidant genes including heme oxygenase-1 (HMOX1), following exposure to sodium arsenite or cadmium chloride in lamin knockdown human cell lines and primary HGPS human fibroblasts.	sodium arsenite	176-191	NFE2 like bZIP transcription factor 2	Homo sapiens	70-74
28229933-5	2017	We investigated the activation of nuclear factor-E2-related factor 2 (Nrf2) which regulates various antioxidant genes including heme oxygenase-1 (HMOX1), following exposure to sodium arsenite or cadmium chloride in lamin knockdown human cell lines and primary HGPS human fibroblasts.	sodium arsenite	176-191	heme oxygenase 1	Homo sapiens	128-144
28229933-5	2017	We investigated the activation of nuclear factor-E2-related factor 2 (Nrf2) which regulates various antioxidant genes including heme oxygenase-1 (HMOX1), following exposure to sodium arsenite or cadmium chloride in lamin knockdown human cell lines and primary HGPS human fibroblasts.	sodium arsenite	176-191	heme oxygenase 1	Homo sapiens	146-151
28189647-3	2017	Therefore, in this study we examined the effects of monomethylarsonous acid (MMA(III)) as compared to its parent compound sodium arsenite (As(III)) on the expression of CYP1A1 in HepG2 cells.	sodium arsenite	122-137	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	169-175
28480809-6	2017	SA exposure also inhibited the pathways of glucose metabolism while increasing AMP deaminase and glyoxalase-I.	sodium arsenite	0-2	glyoxalase I	Homo sapiens	97-109
28011284-8	2017	These data suggested that JNK-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP and facilitates the efficient recruitment of Tudor-SN into SGs under conditions of sodium arsenite-induced oxidative stress.	sodium arsenite	198-213	mitogen-activated protein kinase 8	Homo sapiens	26-29
28011284-8	2017	These data suggested that JNK-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP and facilitates the efficient recruitment of Tudor-SN into SGs under conditions of sodium arsenite-induced oxidative stress.	sodium arsenite	198-213	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	39-47
28011284-8	2017	These data suggested that JNK-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP and facilitates the efficient recruitment of Tudor-SN into SGs under conditions of sodium arsenite-induced oxidative stress.	sodium arsenite	198-213	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	97-105
28011284-8	2017	These data suggested that JNK-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP and facilitates the efficient recruitment of Tudor-SN into SGs under conditions of sodium arsenite-induced oxidative stress.	sodium arsenite	198-213	G3BP stress granule assembly factor 1	Homo sapiens	110-114
28011284-8	2017	These data suggested that JNK-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP and facilitates the efficient recruitment of Tudor-SN into SGs under conditions of sodium arsenite-induced oxidative stress.	sodium arsenite	198-213	staphylococcal nuclease and tudor domain containing 1	Homo sapiens	97-105
27993642-8	2017	Atg7 and Atg12 levels were obviously higher in all groups treated with sodium arsenite compared to control.	sodium arsenite	71-86	autophagy related 7	Rattus norvegicus	0-4
27993642-8	2017	Atg7 and Atg12 levels were obviously higher in all groups treated with sodium arsenite compared to control.	sodium arsenite	71-86	autophagy related 12	Rattus norvegicus	9-14
27884605-6	2017	Cells exposed to 10muM sodium arsenite increased the stability of HIPK1 and HIPK2 proteins, leading to CREB activation via Ser271 phosphorylation.	sodium arsenite	23-38	cAMP responsive element binding protein 1	Homo sapiens	103-107
28451559-0	2017	Effect of Sodium Arsenite on the Expression of Antioxidant Genes (SOD2 and CAT) in MCF-7 and Jurkat Cell Lines.	sodium arsenite	10-25	superoxide dismutase 2	Homo sapiens	66-70
28451559-0	2017	Effect of Sodium Arsenite on the Expression of Antioxidant Genes (SOD2 and CAT) in MCF-7 and Jurkat Cell Lines.	sodium arsenite	10-25	catalase	Homo sapiens	75-78
28451559-3	2017	The purpose of the present study was to evaluate the alteration of mRNA levels of catalase (CAT) and superoxide dismutase 2 (SOD2) in MCF-7 and Jurkat cells after exposure to NaAsO2.	sodium arsenite	175-181	catalase	Homo sapiens	92-95
28451559-3	2017	The purpose of the present study was to evaluate the alteration of mRNA levels of catalase (CAT) and superoxide dismutase 2 (SOD2) in MCF-7 and Jurkat cells after exposure to NaAsO2.	sodium arsenite	175-181	superoxide dismutase 2	Homo sapiens	101-123
28451559-3	2017	The purpose of the present study was to evaluate the alteration of mRNA levels of catalase (CAT) and superoxide dismutase 2 (SOD2) in MCF-7 and Jurkat cells after exposure to NaAsO2.	sodium arsenite	175-181	superoxide dismutase 2	Homo sapiens	125-129
28451559-5	2017	For evaluating the expression levels of the CAT and SOD2, we used two concentrations of NaAsO2 (5 and 15 muM), lower than the concentrations at which 50% of cell viability were lost.	sodium arsenite	88-94	catalase	Homo sapiens	44-47
28451559-10	2017	RESULTS: CAT mRNA level decreased significantly in both cell lines following exposure to NaAsO2 (P<0.05).	sodium arsenite	89-95	catalase	Homo sapiens	9-12
28451559-11	2017	Expression levels of SOD2 decreased in Jurkat cells and increased in MCF-7 cells after treatment with NaAsO2 (P<0.05).	sodium arsenite	102-108	superoxide dismutase 2	Homo sapiens	21-25
28451559-12	2017	CONCLUSION: After cells exposure to NaAsO2, CAT mRNA level decreased in both examined cell lines but the alterations of SOD2 mRNA level is cell specific.	sodium arsenite	36-42	catalase	Homo sapiens	44-47
28451559-12	2017	CONCLUSION: After cells exposure to NaAsO2, CAT mRNA level decreased in both examined cell lines but the alterations of SOD2 mRNA level is cell specific.	sodium arsenite	36-42	superoxide dismutase 2	Homo sapiens	120-124
28451559-13	2017	The NAC modulated the NaAsO2 associated alterations of CAT and SOD2 mRNA levels, therefore, the NaAsO2 might act through inducing reactive oxygen species.	sodium arsenite	22-28	catalase	Homo sapiens	55-58
28451559-13	2017	The NAC modulated the NaAsO2 associated alterations of CAT and SOD2 mRNA levels, therefore, the NaAsO2 might act through inducing reactive oxygen species.	sodium arsenite	22-28	superoxide dismutase 2	Homo sapiens	63-67
28791301-0	2017	Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats.	sodium arsenite	31-46	vascular endothelial growth factor A	Rattus norvegicus	65-69
28791301-0	2017	Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats.	sodium arsenite	31-46	kinase insert domain receptor	Rattus norvegicus	74-80
27620207-1	2016	PURPOSE: KML-001 (sodium metaarsenite) displaces hTERT from the nucleus and is synergistic with cisplatin.	sodium arsenite	9-16	telomerase reverse transcriptase	Homo sapiens	49-54
29209629-0	2017	Corrigendum to "Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats".	sodium arsenite	47-62	vascular endothelial growth factor A	Rattus norvegicus	81-85
29209629-0	2017	Corrigendum to "Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats".	sodium arsenite	47-62	kinase insert domain receptor	Rattus norvegicus	90-96
27620207-1	2016	PURPOSE: KML-001 (sodium metaarsenite) displaces hTERT from the nucleus and is synergistic with cisplatin.	sodium arsenite	18-37	telomerase reverse transcriptase	Homo sapiens	49-54
27517564-4	2016	The effects of sodium arsenite treatment in CD133+CD13+ hepatocytes were mediated by the post-transcriptional suppression of PML expression and the inhibition of Oct4, Sox2, and Klf4 expression at the transcriptional level.	sodium arsenite	15-30	prominin 1	Homo sapiens	44-49
28172957-5	2016	Under stress conditions induced by sodium arsenite, we found that in human fibroblasts TDP-43 did not translocate to the SGs but instead contributed to the SG formation through a regulatory effect on the G3BP1 core protein.	sodium arsenite	35-50	TAR DNA binding protein	Homo sapiens	87-93
28172957-5	2016	Under stress conditions induced by sodium arsenite, we found that in human fibroblasts TDP-43 did not translocate to the SGs but instead contributed to the SG formation through a regulatory effect on the G3BP1 core protein.	sodium arsenite	35-50	G3BP stress granule assembly factor 1	Homo sapiens	204-209
28007167-0	2016	Examination of in vivo mutagenicity of sodium arsenite and dimethylarsinic acid in gpt delta rats.	sodium arsenite	39-54	glutamic--pyruvic transaminase	Rattus norvegicus	83-86
27517564-4	2016	The effects of sodium arsenite treatment in CD133+CD13+ hepatocytes were mediated by the post-transcriptional suppression of PML expression and the inhibition of Oct4, Sox2, and Klf4 expression at the transcriptional level.	sodium arsenite	15-30	alanyl aminopeptidase, membrane	Homo sapiens	44-48
27517564-4	2016	The effects of sodium arsenite treatment in CD133+CD13+ hepatocytes were mediated by the post-transcriptional suppression of PML expression and the inhibition of Oct4, Sox2, and Klf4 expression at the transcriptional level.	sodium arsenite	15-30	PML nuclear body scaffold	Homo sapiens	125-128
27517564-4	2016	The effects of sodium arsenite treatment in CD133+CD13+ hepatocytes were mediated by the post-transcriptional suppression of PML expression and the inhibition of Oct4, Sox2, and Klf4 expression at the transcriptional level.	sodium arsenite	15-30	POU class 5 homeobox 1	Homo sapiens	162-166
27517564-4	2016	The effects of sodium arsenite treatment in CD133+CD13+ hepatocytes were mediated by the post-transcriptional suppression of PML expression and the inhibition of Oct4, Sox2, and Klf4 expression at the transcriptional level.	sodium arsenite	15-30	SRY-box transcription factor 2	Homo sapiens	168-172
27517564-4	2016	The effects of sodium arsenite treatment in CD133+CD13+ hepatocytes were mediated by the post-transcriptional suppression of PML expression and the inhibition of Oct4, Sox2, and Klf4 expression at the transcriptional level.	sodium arsenite	15-30	Kruppel like factor 4	Homo sapiens	178-182
27129674-6	2016	Our data revealed that treatment with high concentration of sodium arsenite increased caspase-3 cleavage and NF-kappaB level, 9days after injection.	sodium arsenite	60-75	caspase 3	Rattus norvegicus	86-95
25728338-0	2016	Sodium arsenite inhibited genomic estrogen signaling but induced pERalpha (Ser118) via MAPK pathway in breast cancer cells.	sodium arsenite	0-15	mitogen-activated protein kinase 3	Homo sapiens	87-91
25728338-4	2016	The results demonstrated that NaAsO2 dose-dependently increased viability of hormone-dependent breast cancer MCF-7 and T47D cells expressing both ERalpha and ERbeta but not hormone-independent MDA-MB-231 cells expressing ERbeta.	sodium arsenite	30-36	estrogen receptor 1	Homo sapiens	146-153
25728338-4	2016	The results demonstrated that NaAsO2 dose-dependently increased viability of hormone-dependent breast cancer MCF-7 and T47D cells expressing both ERalpha and ERbeta but not hormone-independent MDA-MB-231 cells expressing ERbeta.	sodium arsenite	30-36	estrogen receptor 2	Homo sapiens	158-164
25728338-5	2016	These suggested ERalpha contribution to NaAsO2 -stimulated breast cancer cells growth.	sodium arsenite	40-46	estrogen receptor 1	Homo sapiens	16-23
25728338-6	2016	NaAsO2 induced down-regulation of ERalpha but up-regulation of ERbeta protein expressions in T47D cells.	sodium arsenite	0-6	estrogen receptor 1	Homo sapiens	34-41
25728338-6	2016	NaAsO2 induced down-regulation of ERalpha but up-regulation of ERbeta protein expressions in T47D cells.	sodium arsenite	0-6	estrogen receptor 2	Homo sapiens	63-69
25728338-7	2016	Moreover, NaAsO2 dose-dependently inhibited E2-induced ER transcriptional activity as it decreased E2-mediated ERE-luciferase transcription activation and PgR mRNA transcription but increased pS2 mRNA transcription.	sodium arsenite	10-16	progesterone receptor	Homo sapiens	155-158
25728338-7	2016	Moreover, NaAsO2 dose-dependently inhibited E2-induced ER transcriptional activity as it decreased E2-mediated ERE-luciferase transcription activation and PgR mRNA transcription but increased pS2 mRNA transcription.	sodium arsenite	10-16	trefoil factor 1	Homo sapiens	192-195
25728338-8	2016	However, NaAsO2 induced both rapid and sustained activation of ERK1/2 and increased in phosphorylation of ERalpha at serine 118 residue, c-fos and c-myc protein expressions.	sodium arsenite	9-15	mitogen-activated protein kinase 3	Homo sapiens	63-69
25728338-8	2016	However, NaAsO2 induced both rapid and sustained activation of ERK1/2 and increased in phosphorylation of ERalpha at serine 118 residue, c-fos and c-myc protein expressions.	sodium arsenite	9-15	estrogen receptor 1	Homo sapiens	106-113
25728338-8	2016	However, NaAsO2 induced both rapid and sustained activation of ERK1/2 and increased in phosphorylation of ERalpha at serine 118 residue, c-fos and c-myc protein expressions.	sodium arsenite	9-15	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	137-142
25728338-8	2016	However, NaAsO2 induced both rapid and sustained activation of ERK1/2 and increased in phosphorylation of ERalpha at serine 118 residue, c-fos and c-myc protein expressions.	sodium arsenite	9-15	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	147-152
25728338-9	2016	These results indicated that NaAsO2 interferes the genomic estrogen-signaling pathway but induces activation of a rapid nongenomic signal transduction through ERK1/2 pathway which may contribute to its proliferative effect on hormone-dependent breast cancer cells.	sodium arsenite	29-35	mitogen-activated protein kinase 3	Homo sapiens	159-165
27129674-7	2016	Whereas, low doses of sodium arsenite cause Nrf2 and HO-1 activation and increased CREB phosphorylation in the hippocampus.	sodium arsenite	22-37	NFE2 like bZIP transcription factor 2	Rattus norvegicus	44-48
27129674-7	2016	Whereas, low doses of sodium arsenite cause Nrf2 and HO-1 activation and increased CREB phosphorylation in the hippocampus.	sodium arsenite	22-37	heme oxygenase 1	Rattus norvegicus	53-57
27129674-7	2016	Whereas, low doses of sodium arsenite cause Nrf2 and HO-1 activation and increased CREB phosphorylation in the hippocampus.	sodium arsenite	22-37	cAMP responsive element binding protein 1	Rattus norvegicus	83-87
27129674-9	2016	Moreover, it seems that the neuroprotective effects of ultra-low concentrations of sodium arsenite on Abeta-induced memory impairment is mediated via an increase Nrf2, HO-1 and CREB phosphorylation levels and decrease caspase-3 and NF-kappaB amount.	sodium arsenite	83-98	NFE2 like bZIP transcription factor 2	Rattus norvegicus	162-166
27129674-9	2016	Moreover, it seems that the neuroprotective effects of ultra-low concentrations of sodium arsenite on Abeta-induced memory impairment is mediated via an increase Nrf2, HO-1 and CREB phosphorylation levels and decrease caspase-3 and NF-kappaB amount.	sodium arsenite	83-98	heme oxygenase 1	Rattus norvegicus	168-172
27129674-9	2016	Moreover, it seems that the neuroprotective effects of ultra-low concentrations of sodium arsenite on Abeta-induced memory impairment is mediated via an increase Nrf2, HO-1 and CREB phosphorylation levels and decrease caspase-3 and NF-kappaB amount.	sodium arsenite	83-98	cAMP responsive element binding protein 1	Rattus norvegicus	177-181
27129674-9	2016	Moreover, it seems that the neuroprotective effects of ultra-low concentrations of sodium arsenite on Abeta-induced memory impairment is mediated via an increase Nrf2, HO-1 and CREB phosphorylation levels and decrease caspase-3 and NF-kappaB amount.	sodium arsenite	83-98	caspase 3	Rattus norvegicus	218-227
26066906-7	2016	In addition, NaAsO2 significantly (P<0.05-0.01) altered the expression of intrinsic (Bad , Bcl-2 , cleaved-caspase 3  and cleaved-caspase 9 ) and extrinsic (Fas , Bid , cleaved-caspase 8 ) transcription proteins participating in the apoptotic event.	sodium arsenite	13-19	B cell leukemia/lymphoma 2	Mus musculus	94-99
27306194-0	2016	Nrf2-dependent protection against acute sodium arsenite toxicity in zebrafish.	sodium arsenite	40-55	nfe2 like bZIP transcription factor 2a	Danio rerio	0-4
27306194-3	2016	In the present study, we genetically investigated the protective role of Nrf2 against acute sodium arsenite toxicity using the zebrafish Nrf2 mutant, nrf2a(fh318).	sodium arsenite	92-107	nfe2 like bZIP transcription factor 2a	Danio rerio	73-77
27306194-4	2016	After treatment with 1mM sodium arsenite, the survival of nrf2a(fh318) larvae was significantly shorter than that of wild-type siblings, suggesting that Nrf2 protected the zebrafish larvae against high-dose arsenite exposure.	sodium arsenite	25-40	nfe2 like bZIP transcription factor 2a	Danio rerio	153-157
27306194-7	2016	Based on these results, we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity.	sodium arsenite	114-129	nfe2 like bZIP transcription factor 2a	Danio rerio	42-46
27165637-3	2016	In the present study, mice were used as a model to investigate the oxidative stress levels and the expressions of NRF2-regulated antioxidant substances in both cerebral cortex and hippocampus with 5, 10 and 20 mg/kg NaAsO2 exposure intra-gastrically.	sodium arsenite	216-222	nuclear factor, erythroid derived 2, like 2	Mus musculus	114-118
27165637-5	2016	We also detected rapidly elevation of NRF2 protein levels by enhancement of Nrf2 transcription, especially at 20 mg/kg NaAsO2 exposure group.	sodium arsenite	119-125	nuclear factor, erythroid derived 2, like 2	Mus musculus	38-42
27165637-5	2016	We also detected rapidly elevation of NRF2 protein levels by enhancement of Nrf2 transcription, especially at 20 mg/kg NaAsO2 exposure group.	sodium arsenite	119-125	nuclear factor, erythroid derived 2, like 2	Mus musculus	76-80
27132035-5	2016	After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3).	sodium arsenite	6-12	microRNA 4255	Homo sapiens	51-66
27132035-5	2016	After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3).	sodium arsenite	6-12	microRNA 4255	Homo sapiens	68-78
27132035-5	2016	After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3).	sodium arsenite	6-12	microRNA 4255	Homo sapiens	136-146
27132035-5	2016	After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3).	sodium arsenite	6-12	programmed cell death 10	Homo sapiens	219-252
27132035-5	2016	After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3).	sodium arsenite	6-12	programmed cell death 10	Homo sapiens	254-258
27132035-5	2016	After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3).	sodium arsenite	160-166	microRNA 4255	Homo sapiens	51-66
27132035-5	2016	After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3).	sodium arsenite	160-166	microRNA 4255	Homo sapiens	68-78
27132035-5	2016	After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3).	sodium arsenite	160-166	microRNA 4255	Homo sapiens	136-146
27132035-5	2016	After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3).	sodium arsenite	160-166	programmed cell death 10	Homo sapiens	219-252
27132035-5	2016	After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3).	sodium arsenite	160-166	programmed cell death 10	Homo sapiens	254-258
27132035-6	2016	Furthermore, we showed that NaAsO2 up-regulated CCM3 expression in vitro and in vivo.	sodium arsenite	28-34	programmed cell death 10	Homo sapiens	48-52
27132035-7	2016	In addition, we demonstrated that inhibition of Notch and activation of VEGF/p38 signaling were involved in miR-425-5p blocking NaAsO2-induced anti-angiogenesis.	sodium arsenite	128-134	mitogen-activated protein kinase 14	Homo sapiens	77-80
27132035-7	2016	In addition, we demonstrated that inhibition of Notch and activation of VEGF/p38 signaling were involved in miR-425-5p blocking NaAsO2-induced anti-angiogenesis.	sodium arsenite	128-134	microRNA 4255	Homo sapiens	108-118
26984302-4	2016	The aim of the present study was to explore the role of a Obg-like ATPase1 (OLA1) in the cell transformation of BALB/c 3T3 A31-1-1 clonal cells induced by a metal mixture (2 microM NaAsO2, 2 microM CdCl2 and 5 microM Pb(C2H3O2)2 3H2O) through ROS generation.	sodium arsenite	181-187	Obg-like ATPase 1	Mus musculus	58-74
26984302-4	2016	The aim of the present study was to explore the role of a Obg-like ATPase1 (OLA1) in the cell transformation of BALB/c 3T3 A31-1-1 clonal cells induced by a metal mixture (2 microM NaAsO2, 2 microM CdCl2 and 5 microM Pb(C2H3O2)2 3H2O) through ROS generation.	sodium arsenite	181-187	Obg-like ATPase 1	Mus musculus	76-80
26066906-7	2016	In addition, NaAsO2 significantly (P<0.05-0.01) altered the expression of intrinsic (Bad , Bcl-2 , cleaved-caspase 3  and cleaved-caspase 9 ) and extrinsic (Fas , Bid , cleaved-caspase 8 ) transcription proteins participating in the apoptotic event.	sodium arsenite	13-19	caspase 9	Mus musculus	133-142
26066906-7	2016	In addition, NaAsO2 significantly (P<0.05-0.01) altered the expression of intrinsic (Bad , Bcl-2 , cleaved-caspase 3  and cleaved-caspase 9 ) and extrinsic (Fas , Bid , cleaved-caspase 8 ) transcription proteins participating in the apoptotic event.	sodium arsenite	13-19	BH3 interacting domain death agonist	Mus musculus	166-169
27071941-6	2016	Inhibitor studies suggest that rapid MAPK phosphorylation by NaAsO2, CdCl2, and E2 involves ER, Src, epidermal growth factor receptor, and G-protein coupled ER (GPER) in a pertussis toxin-sensitive pathway.	sodium arsenite	61-67	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	96-99
27071941-6	2016	Inhibitor studies suggest that rapid MAPK phosphorylation by NaAsO2, CdCl2, and E2 involves ER, Src, epidermal growth factor receptor, and G-protein coupled ER (GPER) in a pertussis toxin-sensitive pathway.	sodium arsenite	61-67	epidermal growth factor receptor	Homo sapiens	101-133
27071941-6	2016	Inhibitor studies suggest that rapid MAPK phosphorylation by NaAsO2, CdCl2, and E2 involves ER, Src, epidermal growth factor receptor, and G-protein coupled ER (GPER) in a pertussis toxin-sensitive pathway.	sodium arsenite	61-67	G protein-coupled estrogen receptor 1	Homo sapiens	139-159
27071941-6	2016	Inhibitor studies suggest that rapid MAPK phosphorylation by NaAsO2, CdCl2, and E2 involves ER, Src, epidermal growth factor receptor, and G-protein coupled ER (GPER) in a pertussis toxin-sensitive pathway.	sodium arsenite	61-67	G protein-coupled estrogen receptor 1	Homo sapiens	161-165
27071941-8	2016	This study supports the involvement of membrane ER and GPER signaling in mediating cellular responses to environmentally relevant nM concentrations of CdCl2 and NaAsO2 in lung adenocarcinoma cells.	sodium arsenite	161-167	G protein-coupled estrogen receptor 1	Homo sapiens	55-59
26066906-7	2016	In addition, NaAsO2 significantly (P<0.05-0.01) altered the expression of intrinsic (Bad , Bcl-2 , cleaved-caspase 3  and cleaved-caspase 9 ) and extrinsic (Fas , Bid , cleaved-caspase 8 ) transcription proteins participating in the apoptotic event.	sodium arsenite	13-19	caspase 8	Mus musculus	180-189
27459794-3	2016	Western blot was used to evaluate the expression of Nrf2, quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (10-1) during sodium arsenite-induced transformation of HBE cells.	sodium arsenite	125-140	NFE2 like bZIP transcription factor 2	Homo sapiens	52-56
26349760-9	2016	Furthermore, NaAsO2 administration increased serum values of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and bilirubin.	sodium arsenite	13-19	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	93-119
26349760-9	2016	Furthermore, NaAsO2 administration increased serum values of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and bilirubin.	sodium arsenite	13-19	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	121-124
27459794-3	2016	Western blot was used to evaluate the expression of Nrf2, quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (10-1) during sodium arsenite-induced transformation of HBE cells.	sodium arsenite	125-140	NAD(P)H quinone dehydrogenase 1	Homo sapiens	84-88
27459794-3	2016	Western blot was used to evaluate the expression of Nrf2, quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (10-1) during sodium arsenite-induced transformation of HBE cells.	sodium arsenite	125-140	heme oxygenase 1	Homo sapiens	94-110
27459794-7	2016	CONCLUSION: The transformation of HBE cells induced by chronic exposure to sodium arsenite is mediated by decreased Nrf2 level and its downstream NQO1 and HO-1 protein, which subsequently promote the malignant proliferation.	sodium arsenite	75-90	NFE2 like bZIP transcription factor 2	Homo sapiens	116-120
27459794-7	2016	CONCLUSION: The transformation of HBE cells induced by chronic exposure to sodium arsenite is mediated by decreased Nrf2 level and its downstream NQO1 and HO-1 protein, which subsequently promote the malignant proliferation.	sodium arsenite	75-90	NAD(P)H quinone dehydrogenase 1	Homo sapiens	146-150
27459794-7	2016	CONCLUSION: The transformation of HBE cells induced by chronic exposure to sodium arsenite is mediated by decreased Nrf2 level and its downstream NQO1 and HO-1 protein, which subsequently promote the malignant proliferation.	sodium arsenite	75-90	heme oxygenase 1	Homo sapiens	155-159
25787150-4	2016	The results demonstrated that exposure to 10 muM sodium arsenite up to 14 days induces a great increase in G0/G1 arrest, irreversible cell growth suppression, cellular morphological changes and positive staining for senescence-associated beta-galactosidase.	sodium arsenite	49-64	galactosidase, beta 1	Mus musculus	238-256
26631322-7	2016	NaAsO2 suppressed the autophagic flux in tubular cells through the activation of ERK.	sodium arsenite	0-6	mitogen-activated protein kinase 1	Mus musculus	81-84
26231544-2	2016	Expressions of Rac1 and Cdc42 in rat cerebellum and cerebrum exposed to different doses of NaAsO2 (Wistar rats drank 0, 2, 10, and 50 mg/L NaAsO2 water for 3 months) were examined.	sodium arsenite	91-97	Rac family small GTPase 1	Rattus norvegicus	15-19
26231544-5	2016	Rac1 inhibitor, NSC23766, decreased NaAsO2-induced apoptosis and increased the cell viability in primary cultured rat cerebellar astrocytes exposed to 30 muM NaAsO2.	sodium arsenite	36-42	Rac family small GTPase 1	Rattus norvegicus	0-4
26231544-5	2016	Rac1 inhibitor, NSC23766, decreased NaAsO2-induced apoptosis and increased the cell viability in primary cultured rat cerebellar astrocytes exposed to 30 muM NaAsO2.	sodium arsenite	158-164	Rac family small GTPase 1	Rattus norvegicus	0-4
26231544-6	2016	Cdc42 inhibitor, ZCL278, increased cell viability in the cells exposed to 30 muM NaAsO2.	sodium arsenite	81-87	cell division cycle 42	Rattus norvegicus	0-5
26497187-3	2016	Sodium arsenite (1.5 mg/kg, i.p., 2 weeks) abrogated the acetylcholine-induced, endothelium-dependent vasorelaxation by depicting the decrease in serum nitrite/nitrate concentration, reduced glutathione level, and simultaneously enhance the thiobarbituric acid reactive substances (TBARS) level, superoxide level, and tumor necrosis factor-alpha.	sodium arsenite	0-15	tumor necrosis factor	Homo sapiens	318-345
26631322-9	2016	The IL-6/STAT3 signaling pathway had protective roles in NaAsO2-induced nephrotoxicity through the suppression of ERK activation.	sodium arsenite	57-63	interleukin 6	Mus musculus	4-8
26631322-9	2016	The IL-6/STAT3 signaling pathway had protective roles in NaAsO2-induced nephrotoxicity through the suppression of ERK activation.	sodium arsenite	57-63	signal transducer and activator of transcription 3	Mus musculus	9-14
26631322-9	2016	The IL-6/STAT3 signaling pathway had protective roles in NaAsO2-induced nephrotoxicity through the suppression of ERK activation.	sodium arsenite	57-63	mitogen-activated protein kinase 1	Mus musculus	114-117
26432159-4	2015	This study found that cells treated with sodium arsenite had reduced 8-oxoguanine DNA glycosylase 1 (OGG1) and increased 8-hydroxy-2"-deoxyguanosine (8-OHdG) and activating transcription factor (ATF) 3 in SV-40 immortalized human uroepithelial (SV-HUC-1) cells.	sodium arsenite	41-56	8-oxoguanine DNA glycosylase	Homo sapiens	69-99
26432159-4	2015	This study found that cells treated with sodium arsenite had reduced 8-oxoguanine DNA glycosylase 1 (OGG1) and increased 8-hydroxy-2"-deoxyguanosine (8-OHdG) and activating transcription factor (ATF) 3 in SV-40 immortalized human uroepithelial (SV-HUC-1) cells.	sodium arsenite	41-56	8-oxoguanine DNA glycosylase	Homo sapiens	101-105
26432159-4	2015	This study found that cells treated with sodium arsenite had reduced 8-oxoguanine DNA glycosylase 1 (OGG1) and increased 8-hydroxy-2"-deoxyguanosine (8-OHdG) and activating transcription factor (ATF) 3 in SV-40 immortalized human uroepithelial (SV-HUC-1) cells.	sodium arsenite	41-56	activating transcription factor 3	Homo sapiens	162-201
26528920-6	2015	In ~80% of cells treated with sodium arsenite (Ars) to induce cytoplasmic stress granules, the nuclear localization of WT and F115C mutant Matrin 3 was not disturbed.	sodium arsenite	30-45	matrin 3	Homo sapiens	139-147
26485141-7	2015	Sodium arsenite at a dose of 40 mg/L supplied via drinking water in mice significantly raised the serum level of liver function markers such as AST, ALT, and ALP, and caused arsenic deposition in liver and ROS generation, though it did not show any lethality up to 30 days of exposure.	sodium arsenite	0-15	transmembrane protease, serine 11d	Mus musculus	144-147
26485141-7	2015	Sodium arsenite at a dose of 40 mg/L supplied via drinking water in mice significantly raised the serum level of liver function markers such as AST, ALT, and ALP, and caused arsenic deposition in liver and ROS generation, though it did not show any lethality up to 30 days of exposure.	sodium arsenite	0-15	glutamic pyruvic transaminase, soluble	Mus musculus	149-152
26259607-10	2015	The increases of HSPA8 and ENO1 levels were also detected in CM of HK-2 cells treated with other nephrotoxic agents, such as HgCl2, NaAsO2, cisplatin, amphotericin B, and cyclosporine A.	sodium arsenite	132-138	heat shock protein family A (Hsp70) member 8	Homo sapiens	17-22
26260897-1	2015	In the present study, treatment of Xenopus laevis A6 kidney epithelial cells with the proteasomal inhibitor, MG132, or the environmental toxicants, sodium arsenite or cadmium chloride, induced the accumulation of the small heat shock protein, HSP30, in total and in both soluble and insoluble protein fractions.	sodium arsenite	148-163	heat shock 70kDa protein L homeolog	Xenopus laevis	223-241
26260897-1	2015	In the present study, treatment of Xenopus laevis A6 kidney epithelial cells with the proteasomal inhibitor, MG132, or the environmental toxicants, sodium arsenite or cadmium chloride, induced the accumulation of the small heat shock protein, HSP30, in total and in both soluble and insoluble protein fractions.	sodium arsenite	148-163	heat shock protein 30E L homeolog	Xenopus laevis	243-248
26259607-10	2015	The increases of HSPA8 and ENO1 levels were also detected in CM of HK-2 cells treated with other nephrotoxic agents, such as HgCl2, NaAsO2, cisplatin, amphotericin B, and cyclosporine A.	sodium arsenite	132-138	enolase 1	Homo sapiens	27-31
26341012-11	2015	Plumbagin, and the GR inhibitor sodium arsenite all increased intracellular reactive oxygen species (ROS) levels and this increase was significantly attenuated by pretreatment with the ROS scavenger N-acetyl-cysteine (NAC) in HepG2 cells.	sodium arsenite	32-47	glutathione-disulfide reductase	Homo sapiens	19-21
26473898-5	2015	Our results showed 10 mg/kg NaAsO2 elevated the NRF2 protein and increased the transcription of Nrf2 mRNA, as well as up-regulated NRF2 downstream targets HO-1, GST and GCLC time- and dose-dependently both in the liver and kidney.	sodium arsenite	28-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	48-52
26473898-5	2015	Our results showed 10 mg/kg NaAsO2 elevated the NRF2 protein and increased the transcription of Nrf2 mRNA, as well as up-regulated NRF2 downstream targets HO-1, GST and GCLC time- and dose-dependently both in the liver and kidney.	sodium arsenite	28-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-100
26473898-5	2015	Our results showed 10 mg/kg NaAsO2 elevated the NRF2 protein and increased the transcription of Nrf2 mRNA, as well as up-regulated NRF2 downstream targets HO-1, GST and GCLC time- and dose-dependently both in the liver and kidney.	sodium arsenite	28-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135
26473898-5	2015	Our results showed 10 mg/kg NaAsO2 elevated the NRF2 protein and increased the transcription of Nrf2 mRNA, as well as up-regulated NRF2 downstream targets HO-1, GST and GCLC time- and dose-dependently both in the liver and kidney.	sodium arsenite	28-34	heme oxygenase 1	Mus musculus	155-159
26473898-5	2015	Our results showed 10 mg/kg NaAsO2 elevated the NRF2 protein and increased the transcription of Nrf2 mRNA, as well as up-regulated NRF2 downstream targets HO-1, GST and GCLC time- and dose-dependently both in the liver and kidney.	sodium arsenite	28-34	glutamate-cysteine ligase, catalytic subunit	Mus musculus	169-173
26870803-2	2015	In this study, we show that microglia stressed by exposure to sodium arsenite or Abeta(1-42) peptides or fibrils form extensive stress granules (SGs) to which the tyrosine kinase, SYK, is recruited.	sodium arsenite	62-77	spleen associated tyrosine kinase	Homo sapiens	180-183
26371860-3	2015	Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h.	sodium arsenite	48-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135
26371860-3	2015	Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h.	sodium arsenite	48-63	heme oxygenase 1	Mus musculus	163-179
26371860-3	2015	Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h.	sodium arsenite	48-63	heme oxygenase 1	Mus musculus	181-185
26371860-3	2015	Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h.	sodium arsenite	48-63	hematopoietic prostaglandin D synthase	Mus musculus	188-213
26371860-3	2015	Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h.	sodium arsenite	48-63	hematopoietic prostaglandin D synthase	Mus musculus	215-218
26371860-3	2015	Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h.	sodium arsenite	48-63	glutathione reductase	Mus musculus	257-278
26371860-3	2015	Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h.	sodium arsenite	48-63	glutathione reductase	Mus musculus	280-282
26066304-7	2015	Pretreatment of C2C12 cells with the JNK inhibitor SP600125 induced a decrease in c-Jun and Nrf2 content and was able to counteract the NaAsO2-mediated increase in CRYAB expression.	sodium arsenite	136-142	crystallin, alpha B	Mus musculus	164-169
25982963-5	2015	This inhibitory effect of NaAsO2 was attenuated by insulin.	sodium arsenite	26-32	insulin	Homo sapiens	51-58
26066304-3	2015	Here we show that noncytotoxic exposure to sodium meta-arsenite (NaAsO2) inducing redox imbalance is able to increase the CRYAB content of C2C12 myoblasts in a transcription-dependent manner.	sodium arsenite	43-63	crystallin, alpha B	Mus musculus	122-127
26066304-3	2015	Here we show that noncytotoxic exposure to sodium meta-arsenite (NaAsO2) inducing redox imbalance is able to increase the CRYAB content of C2C12 myoblasts in a transcription-dependent manner.	sodium arsenite	65-71	crystallin, alpha B	Mus musculus	122-127
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	109-115	nuclear factor, erythroid derived 2, like 2	Mus musculus	42-46
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	109-115	jun proto-oncogene	Mus musculus	55-59
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	109-115	jun proto-oncogene	Mus musculus	70-75
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	109-115	jun proto-oncogene	Mus musculus	190-195
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	109-115	nuclear factor, erythroid derived 2, like 2	Mus musculus	200-204
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	109-115	crystallin, alpha B	Mus musculus	297-302
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	162-168	nuclear factor, erythroid derived 2, like 2	Mus musculus	42-46
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	162-168	jun proto-oncogene	Mus musculus	55-59
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	162-168	jun proto-oncogene	Mus musculus	70-75
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	162-168	jun proto-oncogene	Mus musculus	190-195
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	162-168	nuclear factor, erythroid derived 2, like 2	Mus musculus	200-204
26066304-5	2015	The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance.	sodium arsenite	162-168	crystallin, alpha B	Mus musculus	297-302
26066304-7	2015	Pretreatment of C2C12 cells with the JNK inhibitor SP600125 induced a decrease in c-Jun and Nrf2 content and was able to counteract the NaAsO2-mediated increase in CRYAB expression.	sodium arsenite	136-142	mitogen-activated protein kinase 8	Mus musculus	37-40
26291581-0	2015	Low-level sodium arsenite induces apoptosis through inhibiting TrxR activity in pancreatic beta-cells.	sodium arsenite	10-25	peroxiredoxin 5	Rattus norvegicus	63-67
26291581-2	2015	Since the thioredoxin (Trx) system is the key antioxidant factor in mammalian cells, we investigate whether the inhibition of Trx system contributes to sodium arsenite-induced apoptosis in this study.	sodium arsenite	152-167	thioredoxin	Homo sapiens	126-129
26291581-3	2015	After treatment with low-level (0.25-1muM) sodium arsenite for 96h, the thioredoxin reductase (TrxR) activity was decreased significantly in pancreatic INS-1 cells.	sodium arsenite	43-58	peroxiredoxin 5	Rattus norvegicus	72-93
26291581-3	2015	After treatment with low-level (0.25-1muM) sodium arsenite for 96h, the thioredoxin reductase (TrxR) activity was decreased significantly in pancreatic INS-1 cells.	sodium arsenite	43-58	peroxiredoxin 5	Rattus norvegicus	95-99
26291581-4	2015	Following with the inactivation of TrxR, ASK1 was released from combining with Trx, which was evidenced by increased levels of ASK1 in sodium arsenite-treated INS-1 cells.	sodium arsenite	135-150	peroxiredoxin 5	Rattus norvegicus	35-39
26291581-4	2015	Following with the inactivation of TrxR, ASK1 was released from combining with Trx, which was evidenced by increased levels of ASK1 in sodium arsenite-treated INS-1 cells.	sodium arsenite	135-150	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	41-45
26291581-4	2015	Following with the inactivation of TrxR, ASK1 was released from combining with Trx, which was evidenced by increased levels of ASK1 in sodium arsenite-treated INS-1 cells.	sodium arsenite	135-150	thioredoxin 1	Rattus norvegicus	35-38
26291581-4	2015	Following with the inactivation of TrxR, ASK1 was released from combining with Trx, which was evidenced by increased levels of ASK1 in sodium arsenite-treated INS-1 cells.	sodium arsenite	135-150	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	127-131
26291581-6	2015	Finally, low-level sodium arsenite induced apoptosis via caspase-3 in INS-1 cells.	sodium arsenite	19-34	caspase 3	Rattus norvegicus	57-66
26291581-7	2015	Knockdown of ASK1 alleviated sodium arsenite-induced apoptosis.	sodium arsenite	29-44	mitogen-activated protein kinase kinase kinase 5	Rattus norvegicus	13-17
25982963-6	2015	It was found that blocking PI3K or Akt by selective inhibitors canceled the protective effect of insulin against NaAsO2-induced neurite outgrowth impairment suggesting the essential role of active PI3K and Akt in insulin"s protective action.	sodium arsenite	113-119	AKT serine/threonine kinase 1	Homo sapiens	35-38
25982963-6	2015	It was found that blocking PI3K or Akt by selective inhibitors canceled the protective effect of insulin against NaAsO2-induced neurite outgrowth impairment suggesting the essential role of active PI3K and Akt in insulin"s protective action.	sodium arsenite	113-119	insulin	Homo sapiens	97-104
25982963-6	2015	It was found that blocking PI3K or Akt by selective inhibitors canceled the protective effect of insulin against NaAsO2-induced neurite outgrowth impairment suggesting the essential role of active PI3K and Akt in insulin"s protective action.	sodium arsenite	113-119	AKT serine/threonine kinase 1	Homo sapiens	206-209
25982963-6	2015	It was found that blocking PI3K or Akt by selective inhibitors canceled the protective effect of insulin against NaAsO2-induced neurite outgrowth impairment suggesting the essential role of active PI3K and Akt in insulin"s protective action.	sodium arsenite	113-119	insulin	Homo sapiens	213-220
25982963-8	2015	Moreover, NaAsO2 decreased the Akt activity, as it caused reduction in Akt phosphorylation, and downregulated expression of SIRT1.	sodium arsenite	10-16	AKT serine/threonine kinase 1	Homo sapiens	31-34
25982963-8	2015	Moreover, NaAsO2 decreased the Akt activity, as it caused reduction in Akt phosphorylation, and downregulated expression of SIRT1.	sodium arsenite	10-16	AKT serine/threonine kinase 1	Homo sapiens	71-74
25982963-8	2015	Moreover, NaAsO2 decreased the Akt activity, as it caused reduction in Akt phosphorylation, and downregulated expression of SIRT1.	sodium arsenite	10-16	sirtuin 1	Homo sapiens	124-129
25982963-9	2015	Additionally, the reduction of these signals by NaAsO2 was attenuated by insulin.	sodium arsenite	48-54	insulin	Homo sapiens	73-80
25797979-7	2015	The weight gain of SA-exposed mice was decreased compared with the controls; however, this decrease in body weight gain was prevented when the feed was supplemented with PLE.	sodium arsenite	19-21	perinatal lethality	Mus musculus	170-173
26024302-4	2015	P19 cells were exposed to 0, 0.1, or 0.5 muM sodium arsenite and induced to form embryoid bodies over a period of 5 days.	sodium arsenite	45-60	interleukin 23, alpha subunit p19	Mus musculus	0-3
26137629-5	2015	RESULTS: A marked increase in the secretion of active MMP-9 in the arsenic-treated (1.0 mumol/L NaAsO2) cells was observed in comparison to the passage-matched untreated control (0.0 mumol/L NaAsO2) cells at 28 and 35 passages.	sodium arsenite	96-102	matrix metallopeptidase 9	Homo sapiens	54-59
26137629-5	2015	RESULTS: A marked increase in the secretion of active MMP-9 in the arsenic-treated (1.0 mumol/L NaAsO2) cells was observed in comparison to the passage-matched untreated control (0.0 mumol/L NaAsO2) cells at 28 and 35 passages.	sodium arsenite	191-197	matrix metallopeptidase 9	Homo sapiens	54-59
24961358-5	2015	On the other hand, sodium arsenite activated pro-inflammatory signals, including beta-catenin, nuclear factor-kappaB (NF-kappaB), p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor alpha and cyclooxygenase-2 (COX-2).	sodium arsenite	19-34	mitogen-activated protein kinase 14	Homo sapiens	130-166
24961358-5	2015	On the other hand, sodium arsenite activated pro-inflammatory signals, including beta-catenin, nuclear factor-kappaB (NF-kappaB), p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor alpha and cyclooxygenase-2 (COX-2).	sodium arsenite	19-34	tumor necrosis factor	Homo sapiens	175-202
24961358-5	2015	On the other hand, sodium arsenite activated pro-inflammatory signals, including beta-catenin, nuclear factor-kappaB (NF-kappaB), p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor alpha and cyclooxygenase-2 (COX-2).	sodium arsenite	19-34	prostaglandin-endoperoxide synthase 2	Homo sapiens	207-223
24961358-5	2015	On the other hand, sodium arsenite activated pro-inflammatory signals, including beta-catenin, nuclear factor-kappaB (NF-kappaB), p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor alpha and cyclooxygenase-2 (COX-2).	sodium arsenite	19-34	prostaglandin-endoperoxide synthase 2	Homo sapiens	225-230
26130939-7	2015	RESULTS: NaAsO2 caused significant increases (P < 0.05) in MDA levels and MPO activity, with significant reductions (P < 0.05) in GST, GPX, CAT and SOD activities in the stomach and intestines.	sodium arsenite	9-15	myeloperoxidase	Rattus norvegicus	77-80
26130939-7	2015	RESULTS: NaAsO2 caused significant increases (P < 0.05) in MDA levels and MPO activity, with significant reductions (P < 0.05) in GST, GPX, CAT and SOD activities in the stomach and intestines.	sodium arsenite	9-15	catalase	Rattus norvegicus	146-149
25576766-5	2015	We also investigated the diabetogenic ability of splenocytes using an adoptive transfer model and the effect of SA on the proliferation, activation, and expression of glucose transporter 1 (Glut1) in splenocytes treated with SA in vitro and splenocytes isolated from SA-treated mice.	sodium arsenite	112-114	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	167-188
25576766-5	2015	We also investigated the diabetogenic ability of splenocytes using an adoptive transfer model and the effect of SA on the proliferation, activation, and expression of glucose transporter 1 (Glut1) in splenocytes treated with SA in vitro and splenocytes isolated from SA-treated mice.	sodium arsenite	112-114	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	190-195
25576766-5	2015	We also investigated the diabetogenic ability of splenocytes using an adoptive transfer model and the effect of SA on the proliferation, activation, and expression of glucose transporter 1 (Glut1) in splenocytes treated with SA in vitro and splenocytes isolated from SA-treated mice.	sodium arsenite	225-227	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	167-188
25576766-5	2015	We also investigated the diabetogenic ability of splenocytes using an adoptive transfer model and the effect of SA on the proliferation, activation, and expression of glucose transporter 1 (Glut1) in splenocytes treated with SA in vitro and splenocytes isolated from SA-treated mice.	sodium arsenite	225-227	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	190-195
25576766-5	2015	We also investigated the diabetogenic ability of splenocytes using an adoptive transfer model and the effect of SA on the proliferation, activation, and expression of glucose transporter 1 (Glut1) in splenocytes treated with SA in vitro and splenocytes isolated from SA-treated mice.	sodium arsenite	225-227	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	167-188
25576766-5	2015	We also investigated the diabetogenic ability of splenocytes using an adoptive transfer model and the effect of SA on the proliferation, activation, and expression of glucose transporter 1 (Glut1) in splenocytes treated with SA in vitro and splenocytes isolated from SA-treated mice.	sodium arsenite	225-227	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	190-195
25576766-8	2015	The number of total splenocytes and T cells and both the number and the proportion of CD4+ IFN-gamma+ and CD8+ IFN-gamma+ T cells in the spleen were significantly reduced in SA-treated NOD mice compared with controls.	sodium arsenite	174-176	CD4 antigen	Mus musculus	86-89
25576766-8	2015	The number of total splenocytes and T cells and both the number and the proportion of CD4+ IFN-gamma+ and CD8+ IFN-gamma+ T cells in the spleen were significantly reduced in SA-treated NOD mice compared with controls.	sodium arsenite	174-176	interferon gamma	Mus musculus	91-100
25576766-8	2015	The number of total splenocytes and T cells and both the number and the proportion of CD4+ IFN-gamma+ and CD8+ IFN-gamma+ T cells in the spleen were significantly reduced in SA-treated NOD mice compared with controls.	sodium arsenite	174-176	interferon gamma	Mus musculus	111-120
25576766-11	2015	In addition, the expression of Glut1 and phosphorylated ERK1/2 was decreased by SA treatment.	sodium arsenite	80-82	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	31-36
25576766-11	2015	In addition, the expression of Glut1 and phosphorylated ERK1/2 was decreased by SA treatment.	sodium arsenite	80-82	mitogen-activated protein kinase 3	Mus musculus	56-62
25924428-3	2015	The expression level of ERalpha mRNA and protein in lung tissue of the male and female offspring in different developmental periods and different doses (low, middle, high) of sodium arsenite exposure were detected by real-time PCR and Western blot.	sodium arsenite	175-190	estrogen receptor 1 (alpha)	Mus musculus	24-31
25821630-0	2015	Inhibitory effects of sodium arsenite and acacia honey on acetylcholinesterase in rats.	sodium arsenite	22-37	acetylcholinesterase	Rattus norvegicus	58-78
26160017-14	2015	CONCLUSIONS: cytotoxic effects of NaAsO2 on rat CGNs is induced at least partly by Cdc42 and Rac1 activation, and Ngb can inhibit Cdc42 and Rac1 activation to play protective role in rat CGNs exposed to NaAsO2.	sodium arsenite	34-40	cell division cycle 42	Rattus norvegicus	83-88
26160017-14	2015	CONCLUSIONS: cytotoxic effects of NaAsO2 on rat CGNs is induced at least partly by Cdc42 and Rac1 activation, and Ngb can inhibit Cdc42 and Rac1 activation to play protective role in rat CGNs exposed to NaAsO2.	sodium arsenite	34-40	Rac family small GTPase 1	Rattus norvegicus	93-97
26160017-14	2015	CONCLUSIONS: cytotoxic effects of NaAsO2 on rat CGNs is induced at least partly by Cdc42 and Rac1 activation, and Ngb can inhibit Cdc42 and Rac1 activation to play protective role in rat CGNs exposed to NaAsO2.	sodium arsenite	34-40	Rac family small GTPase 1	Rattus norvegicus	140-144
26160017-14	2015	CONCLUSIONS: cytotoxic effects of NaAsO2 on rat CGNs is induced at least partly by Cdc42 and Rac1 activation, and Ngb can inhibit Cdc42 and Rac1 activation to play protective role in rat CGNs exposed to NaAsO2.	sodium arsenite	203-209	neuroglobin	Rattus norvegicus	114-117
26339590-2	2015	The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology.	sodium arsenite	51-66	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	88-93
26339590-2	2015	The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology.	sodium arsenite	51-66	solute carrier family 2 (facilitated glucose transporter), member 3	Mus musculus	95-100
26339590-2	2015	The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology.	sodium arsenite	51-66	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	106-111
26339590-2	2015	The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology.	sodium arsenite	68-74	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	88-93
26339590-2	2015	The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology.	sodium arsenite	68-74	solute carrier family 2 (facilitated glucose transporter), member 3	Mus musculus	95-100
26339590-2	2015	The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology.	sodium arsenite	68-74	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	106-111
26160017-1	2015	BACKGROUND AND AIMS: We have previously shown that neuroglobin (Ngb) expression can be regulated by sodium arsenite (NaAsO2) exposure in rat cerebellar granule neurons (CGNs).	sodium arsenite	100-115	neuroglobin	Rattus norvegicus	51-62
26160017-1	2015	BACKGROUND AND AIMS: We have previously shown that neuroglobin (Ngb) expression can be regulated by sodium arsenite (NaAsO2) exposure in rat cerebellar granule neurons (CGNs).	sodium arsenite	100-115	neuroglobin	Rattus norvegicus	64-67
26160017-1	2015	BACKGROUND AND AIMS: We have previously shown that neuroglobin (Ngb) expression can be regulated by sodium arsenite (NaAsO2) exposure in rat cerebellar granule neurons (CGNs).	sodium arsenite	117-123	neuroglobin	Rattus norvegicus	51-62
26160017-1	2015	BACKGROUND AND AIMS: We have previously shown that neuroglobin (Ngb) expression can be regulated by sodium arsenite (NaAsO2) exposure in rat cerebellar granule neurons (CGNs).	sodium arsenite	117-123	neuroglobin	Rattus norvegicus	64-67
26160017-11	2015	RESULTS: NaAsO2 induced cytotoxicity in rat CGNs, increased GTP-bound form of Cdc42 and Rac1 GTPases in the cells.	sodium arsenite	9-15	cell division cycle 42	Rattus norvegicus	78-83
26160017-11	2015	RESULTS: NaAsO2 induced cytotoxicity in rat CGNs, increased GTP-bound form of Cdc42 and Rac1 GTPases in the cells.	sodium arsenite	9-15	Rac family small GTPase 1	Rattus norvegicus	88-92
26160017-12	2015	Furthermore, inhibition of Cdc42 or Rac1 activity using the inhibitor ZCL278 or NSC23766 decreased apoptosis and increased cell viability in the cells exposed to NaAsO2.	sodium arsenite	162-168	cell division cycle 42	Rattus norvegicus	27-32
26160017-12	2015	Furthermore, inhibition of Cdc42 or Rac1 activity using the inhibitor ZCL278 or NSC23766 decreased apoptosis and increased cell viability in the cells exposed to NaAsO2.	sodium arsenite	162-168	Rac family small GTPase 1	Rattus norvegicus	36-40
26160017-13	2015	Using siRNA-mediated knockdown, we show that NaAsO2-induced cytotoxicity was exacerbated, activation of Cdc42 (GTP-Cdc42) and Rac1 (GTP-Rac1) was increased in Ngb RNA silencing cells.	sodium arsenite	45-51	cell division cycle 42	Rattus norvegicus	104-109
26160017-13	2015	Using siRNA-mediated knockdown, we show that NaAsO2-induced cytotoxicity was exacerbated, activation of Cdc42 (GTP-Cdc42) and Rac1 (GTP-Rac1) was increased in Ngb RNA silencing cells.	sodium arsenite	45-51	cell division cycle 42	Rattus norvegicus	115-120
26160017-13	2015	Using siRNA-mediated knockdown, we show that NaAsO2-induced cytotoxicity was exacerbated, activation of Cdc42 (GTP-Cdc42) and Rac1 (GTP-Rac1) was increased in Ngb RNA silencing cells.	sodium arsenite	45-51	Rac family small GTPase 1	Rattus norvegicus	126-130
26160017-13	2015	Using siRNA-mediated knockdown, we show that NaAsO2-induced cytotoxicity was exacerbated, activation of Cdc42 (GTP-Cdc42) and Rac1 (GTP-Rac1) was increased in Ngb RNA silencing cells.	sodium arsenite	45-51	Rac family small GTPase 1	Rattus norvegicus	132-140
26160017-13	2015	Using siRNA-mediated knockdown, we show that NaAsO2-induced cytotoxicity was exacerbated, activation of Cdc42 (GTP-Cdc42) and Rac1 (GTP-Rac1) was increased in Ngb RNA silencing cells.	sodium arsenite	45-51	neuroglobin	Rattus norvegicus	159-162
25821630-1	2015	This study was conducted to investigate the effect of sodium arsenite and Acacia honey on acetylcholinesterase (AChE) activity and electrolytes in the brain and serum of Wistar rats.	sodium arsenite	54-69	acetylcholinesterase	Rattus norvegicus	90-110
25821630-1	2015	This study was conducted to investigate the effect of sodium arsenite and Acacia honey on acetylcholinesterase (AChE) activity and electrolytes in the brain and serum of Wistar rats.	sodium arsenite	54-69	acetylcholinesterase	Rattus norvegicus	112-116
25821630-3	2015	The sodium arsenite and Acacia honey significantly (P < 0.05) decreased AChE activity in the brain with the combined treatment being more potent.	sodium arsenite	4-19	acetylcholinesterase	Rattus norvegicus	75-79
25821630-4	2015	Furthermore, sodium arsenite and Acacia honey significantly (P < 0.05) decreased AChE activity in the serum.	sodium arsenite	13-28	acetylcholinesterase	Rattus norvegicus	84-88
25821630-7	2015	These findings suggest that sodium arsenite and/or Acacia honey modulates acetylcholinesterase activities which may be explored in the management of Alzheimer"s diseases but this might be counteracted by the hepatotoxicity induced by arsenics.	sodium arsenite	28-43	acetylcholinesterase	Rattus norvegicus	74-94
25105348-5	2015	From the results, co-administration of Acacia honey with sodium arsenite on the animals increased (P < 0.05) glutathione peroxidase, superoxide dismutase and catalase activities with concomitant decrease in malondialdehyde levels and anti-clastogenic effects relative to the group treated with sodium arsenite only.	sodium arsenite	57-72	catalase	Rattus norvegicus	161-169
24412756-5	2014	Dephosphorylated AMPKalpha phosphorylates heat shock factor 1 (HSF1) at Ser303, leading to significant transcriptional suppression of HSP70 and HSP27 in CdCl2- or NaAsO2-treated cells.	sodium arsenite	163-169	heat shock transcription factor 1	Homo sapiens	42-61
25241256-8	2014	Furthermore, we show that NaAsO2 treatment led to a dramatic decrease of the expression level of LMP1 and the cellular protein PML.	sodium arsenite	26-32	PDZ and LIM domain 7	Homo sapiens	97-101
25241256-8	2014	Furthermore, we show that NaAsO2 treatment led to a dramatic decrease of the expression level of LMP1 and the cellular protein PML.	sodium arsenite	26-32	PML nuclear body scaffold	Homo sapiens	127-130
25301106-8	2014	Thus, sodium arsenite may confer its cytotoxic effect partly through the aberrant activation of CDKs and the resultant perturbation of cell cycle progression.	sodium arsenite	6-21	cyclin dependent kinase 1	Homo sapiens	96-100
25271956-6	2014	In a series of more than 30 normal donors, two individuals were found to be sensitive to low concentration (10 nM equivalent ~ 1 ppb drinking water exposure) to sodium arsenite-induced inhibition of T cell proliferation produced by phytohemagglutinin (PHA) and anti-CD3/anti-CD28.	sodium arsenite	161-176	CD28 molecule	Homo sapiens	275-279
24865968-3	2014	Exposure of HCT116 colon cancer cells to sodium arsenite stimulated checkpoint kinase 2 (Chk2)- and mitogen-activated protein kinase p38 (p38(MAPK))-mediated phosphorylation of HuR at positions S88 and T118.	sodium arsenite	41-56	checkpoint kinase 2	Homo sapiens	68-87
24865968-3	2014	Exposure of HCT116 colon cancer cells to sodium arsenite stimulated checkpoint kinase 2 (Chk2)- and mitogen-activated protein kinase p38 (p38(MAPK))-mediated phosphorylation of HuR at positions S88 and T118.	sodium arsenite	41-56	checkpoint kinase 2	Homo sapiens	89-93
24865968-3	2014	Exposure of HCT116 colon cancer cells to sodium arsenite stimulated checkpoint kinase 2 (Chk2)- and mitogen-activated protein kinase p38 (p38(MAPK))-mediated phosphorylation of HuR at positions S88 and T118.	sodium arsenite	41-56	mitogen-activated protein kinase 14	Homo sapiens	133-136
24865968-3	2014	Exposure of HCT116 colon cancer cells to sodium arsenite stimulated checkpoint kinase 2 (Chk2)- and mitogen-activated protein kinase p38 (p38(MAPK))-mediated phosphorylation of HuR at positions S88 and T118.	sodium arsenite	41-56	mitogen-activated protein kinase 14	Homo sapiens	138-141
24865968-3	2014	Exposure of HCT116 colon cancer cells to sodium arsenite stimulated checkpoint kinase 2 (Chk2)- and mitogen-activated protein kinase p38 (p38(MAPK))-mediated phosphorylation of HuR at positions S88 and T118.	sodium arsenite	41-56	ELAV like RNA binding protein 1	Homo sapiens	177-180
24519527-3	2014	We recently demonstrated that a combination of sodium arsenite (NaAsO2) and hyperthermia sensitizes p53-expressing ovarian cancer cells to cisplatin by modulating DNA repair pathway and enhancing platinum accumulation.	sodium arsenite	47-62	tumor protein p53	Homo sapiens	100-103
24519527-3	2014	We recently demonstrated that a combination of sodium arsenite (NaAsO2) and hyperthermia sensitizes p53-expressing ovarian cancer cells to cisplatin by modulating DNA repair pathway and enhancing platinum accumulation.	sodium arsenite	64-70	tumor protein p53	Homo sapiens	100-103
24519527-7	2014	Western blot analysis of cyclin A and cyclin B suggested that combined NaAsO2, hyperthermia, and cisplatin induced mitotic arrest.	sodium arsenite	71-77	cyclin A2	Homo sapiens	25-33
25412313-2	2014	Our present study, for the first time to the best of our knowledge, revealed a potential role of p27 in inhibiting S6-mediated hypoxia-inducible factor-1alpha (HIF-1alpha) protein translation, which contributed to the protection from environmental carcinogen (sodium arsenite)-induced cell transformation.	sodium arsenite	260-275	interferon alpha inducible protein 27	Homo sapiens	97-100
25412313-2	2014	Our present study, for the first time to the best of our knowledge, revealed a potential role of p27 in inhibiting S6-mediated hypoxia-inducible factor-1alpha (HIF-1alpha) protein translation, which contributed to the protection from environmental carcinogen (sodium arsenite)-induced cell transformation.	sodium arsenite	260-275	hypoxia inducible factor 1 subunit alpha	Homo sapiens	160-170
24570342-0	2014	Long-term low-dose exposure of human urothelial cells to sodium arsenite activates lipocalin-2 via promoter hypomethylation.	sodium arsenite	57-72	lipocalin 2	Homo sapiens	83-94
25344162-9	2014	We found that the protein expression levels of Nrf2 were increased in both NaAsO2- and As2O3-treated cells.	sodium arsenite	75-81	NFE2 like bZIP transcription factor 2	Homo sapiens	47-51
23690446-2	2014	In two experiments, we examined the urothelial proliferative effects of treatment with 173 ppm sodium arsenite (100 ppm arsenic) in the drinking water for 6 and 24 hr, and 3, 7, and 14 days in female F344 rats and 43.3 ppm sodium arsenite (25 ppm arsenic) in female C57BL/6 wild-type and arsenic (+3 oxidation state) methyltransferase knockout (As3mt KO) mice that are unable to methylate arsenicals.	sodium arsenite	95-110	arsenite methyltransferase	Rattus norvegicus	266-334
24412756-5	2014	Dephosphorylated AMPKalpha phosphorylates heat shock factor 1 (HSF1) at Ser303, leading to significant transcriptional suppression of HSP70 and HSP27 in CdCl2- or NaAsO2-treated cells.	sodium arsenite	163-169	heat shock transcription factor 1	Homo sapiens	63-67
24412756-5	2014	Dephosphorylated AMPKalpha phosphorylates heat shock factor 1 (HSF1) at Ser303, leading to significant transcriptional suppression of HSP70 and HSP27 in CdCl2- or NaAsO2-treated cells.	sodium arsenite	163-169	heat shock protein family A (Hsp70) member 4	Homo sapiens	134-139
24412756-5	2014	Dephosphorylated AMPKalpha phosphorylates heat shock factor 1 (HSF1) at Ser303, leading to significant transcriptional suppression of HSP70 and HSP27 in CdCl2- or NaAsO2-treated cells.	sodium arsenite	163-169	heat shock protein family B (small) member 1	Homo sapiens	144-149
24585092-9	2014	Importantly, their protective effects against insults from both sodium arsenite and H2O2 were Nrf2-dependent.	sodium arsenite	64-79	NFE2 like bZIP transcription factor 2	Homo sapiens	94-98
24357338-0	2014	p38 and extracellular signal-regulated kinases activations have opposite effects on primary-cultured rat cerebellar granule neurons exposed to sodium arsenite.	sodium arsenite	143-158	mitogen activated protein kinase 14	Rattus norvegicus	0-3
24284797-4	2014	Treatment of a human colon cancer cell line (HCT116) with 100 muM sodium arsenite increased SRSF3-PTC mRNA levels without changing SRSF3-FL mRNA levels.	sodium arsenite	66-81	serine and arginine rich splicing factor 3	Homo sapiens	92-97
24379400-1	2014	Activating transcription factor 5 (ATF5) is a stress-response transcription factor that responds to amino acid limitation and exposure to cadmium chloride (CdCl2) and sodium arsenite (NaAsO2).	sodium arsenite	167-182	activating transcription factor 5	Homo sapiens	0-33
24379400-1	2014	Activating transcription factor 5 (ATF5) is a stress-response transcription factor that responds to amino acid limitation and exposure to cadmium chloride (CdCl2) and sodium arsenite (NaAsO2).	sodium arsenite	167-182	activating transcription factor 5	Homo sapiens	35-39
24379400-1	2014	Activating transcription factor 5 (ATF5) is a stress-response transcription factor that responds to amino acid limitation and exposure to cadmium chloride (CdCl2) and sodium arsenite (NaAsO2).	sodium arsenite	184-190	activating transcription factor 5	Homo sapiens	0-33
24379400-1	2014	Activating transcription factor 5 (ATF5) is a stress-response transcription factor that responds to amino acid limitation and exposure to cadmium chloride (CdCl2) and sodium arsenite (NaAsO2).	sodium arsenite	184-190	activating transcription factor 5	Homo sapiens	35-39
24379400-2	2014	The N-terminal amino acids contribute to the destabilization of the ATF5 protein in steady-state conditions and serve as a stabilization domain in the stress response after CdCl2 or NaAsO2 exposure.	sodium arsenite	182-188	activating transcription factor 5	Homo sapiens	68-72
24100277-4	2014	The apoptosis induced by sodium meta-arsenite was associated with cleavage of caspases 3, 8, and 9, and poly (ADP-ribose) polymerase (PARP) and increased annexin V-positive cells, and was inhibited by the pan-caspase inhibitor Z-VAD-fmk.	sodium arsenite	25-45	poly(ADP-ribose) polymerase 1	Homo sapiens	78-132
24100277-4	2014	The apoptosis induced by sodium meta-arsenite was associated with cleavage of caspases 3, 8, and 9, and poly (ADP-ribose) polymerase (PARP) and increased annexin V-positive cells, and was inhibited by the pan-caspase inhibitor Z-VAD-fmk.	sodium arsenite	25-45	poly(ADP-ribose) polymerase 1	Homo sapiens	134-138
24100277-7	2014	Moreover, sodium meta-arsenite led to the accumulation of intracellular reactive oxygen species (ROS) and N-acetyl-L-cysteine (NAC), a ROS scavenger, decreased sodium meta-arsenite-induced levels of cleaved PARP and LC3-II.	sodium arsenite	10-30	X-linked Kx blood group	Homo sapiens	127-130
24100277-7	2014	Moreover, sodium meta-arsenite led to the accumulation of intracellular reactive oxygen species (ROS) and N-acetyl-L-cysteine (NAC), a ROS scavenger, decreased sodium meta-arsenite-induced levels of cleaved PARP and LC3-II.	sodium arsenite	10-30	poly(ADP-ribose) polymerase 1	Homo sapiens	207-211
24100277-7	2014	Moreover, sodium meta-arsenite led to the accumulation of intracellular reactive oxygen species (ROS) and N-acetyl-L-cysteine (NAC), a ROS scavenger, decreased sodium meta-arsenite-induced levels of cleaved PARP and LC3-II.	sodium arsenite	160-180	X-linked Kx blood group	Homo sapiens	127-130
24100277-7	2014	Moreover, sodium meta-arsenite led to the accumulation of intracellular reactive oxygen species (ROS) and N-acetyl-L-cysteine (NAC), a ROS scavenger, decreased sodium meta-arsenite-induced levels of cleaved PARP and LC3-II.	sodium arsenite	160-180	poly(ADP-ribose) polymerase 1	Homo sapiens	207-211
24100277-8	2014	Propidium iodide (PI) staining also showed that NAC restored membrane integrity, damaged by sodium meta-arsenite.	sodium arsenite	92-112	X-linked Kx blood group	Homo sapiens	48-51
24004876-3	2013	Our results demonstrated that both NaAsO2 and As2O3 caused oxidative stress, genotoxicity, cytotoxicity, cell cycle arrest as well as apoptosis, while As2O3 induced higher production of reactive oxygen species (ROS) with a more remarkable decrease in superoxide dismutase (SOD) activities and intracellular levels of glutathione (GSH) than NaAsO2.	sodium arsenite	35-41	superoxide dismutase 1	Homo sapiens	251-271
25610880-9	2014	The mRNA expressions of genes for gluconeogenesis-related enzymes, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK) were significantly reduced in the liver of SA-treated diabetic db/db mice.	sodium arsenite	188-190	glucose-6-phosphatase, catalytic	Mus musculus	67-88
25610880-9	2014	The mRNA expressions of genes for gluconeogenesis-related enzymes, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK) were significantly reduced in the liver of SA-treated diabetic db/db mice.	sodium arsenite	188-190	glucose-6-phosphatase, catalytic	Mus musculus	90-96
25610880-9	2014	The mRNA expressions of genes for gluconeogenesis-related enzymes, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK) were significantly reduced in the liver of SA-treated diabetic db/db mice.	sodium arsenite	188-190	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	103-136
25610880-9	2014	The mRNA expressions of genes for gluconeogenesis-related enzymes, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK) were significantly reduced in the liver of SA-treated diabetic db/db mice.	sodium arsenite	188-190	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	138-143
25610880-10	2014	In primary hepatocytes, SA treatment decreased glucose production and the expression of G6Pase, PEPCK, and hepatocyte nuclear factor 4 alpha (HNF-4alpha) mRNA.	sodium arsenite	24-26	glucose-6-phosphatase, catalytic	Mus musculus	88-94
25610880-10	2014	In primary hepatocytes, SA treatment decreased glucose production and the expression of G6Pase, PEPCK, and hepatocyte nuclear factor 4 alpha (HNF-4alpha) mRNA.	sodium arsenite	24-26	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	96-101
25610880-10	2014	In primary hepatocytes, SA treatment decreased glucose production and the expression of G6Pase, PEPCK, and hepatocyte nuclear factor 4 alpha (HNF-4alpha) mRNA.	sodium arsenite	24-26	hepatic nuclear factor 4, alpha	Mus musculus	107-140
25610880-10	2014	In primary hepatocytes, SA treatment decreased glucose production and the expression of G6Pase, PEPCK, and hepatocyte nuclear factor 4 alpha (HNF-4alpha) mRNA.	sodium arsenite	24-26	hepatic nuclear factor 4, alpha	Mus musculus	142-152
25610880-11	2014	Small heterodimer partner (SHP) mRNA expression was increased in hepatocytes dependent upon the SA concentration.	sodium arsenite	96-98	nuclear receptor subfamily 0, group B, member 2	Mus musculus	0-25
25610880-11	2014	Small heterodimer partner (SHP) mRNA expression was increased in hepatocytes dependent upon the SA concentration.	sodium arsenite	96-98	nuclear receptor subfamily 0, group B, member 2	Mus musculus	27-30
25610880-12	2014	The expression of Sirt1 mRNA and protein was reduced, and acetylated forkhead box protein O1 (FoxO1) was induced by SA treatment in hepatocytes.	sodium arsenite	116-118	forkhead box O1	Mus musculus	69-92
25610880-12	2014	The expression of Sirt1 mRNA and protein was reduced, and acetylated forkhead box protein O1 (FoxO1) was induced by SA treatment in hepatocytes.	sodium arsenite	116-118	forkhead box O1	Mus musculus	94-99
25610880-14	2014	Oral intubation of SA ameliorates hyperglycemia in db/db mice by reducing hepatic gluconeogenesis through the decrease of Sirt1 expression and increase in acetylated FoxO1.	sodium arsenite	19-21	sirtuin 1	Mus musculus	122-127
25610880-14	2014	Oral intubation of SA ameliorates hyperglycemia in db/db mice by reducing hepatic gluconeogenesis through the decrease of Sirt1 expression and increase in acetylated FoxO1.	sodium arsenite	19-21	forkhead box O1	Mus musculus	166-171
24391030-3	2013	Compared to that in the control cells, the survival rate of ARG1 gene-overexpressing cells was much higher following exposure to lower sodium arsenite (<= 8 microM).	sodium arsenite	135-150	arginase 1	Homo sapiens	60-64
24391030-4	2013	When cells were exposed to lower sodium arsenite for 24 h, the arsenite content of ARG1 gene-overexpressing cells decreased and arsenic efflux increased.	sodium arsenite	33-48	arginase 1	Homo sapiens	83-87
24057451-3	2013	In this study, we investigated the toxic effects of sodium arsenite (NaAsO2) on primary cultured rat cerebellar granule neurons (CGNs) and detected neuroglobin (Ngb) expression in rat CGNs exposed to NaAsO2.	sodium arsenite	200-206	neuroglobin	Rattus norvegicus	148-159
24057451-4	2013	Our results show that apoptosis was obviously induced by NaAsO2 treatment in rat CGNs by annexin V-fluorescein isothiocyanate assay.	sodium arsenite	57-63	annexin A5	Rattus norvegicus	89-98
24057451-6	2013	Ngb protein and mRNA expression were significantly downregulated in rat CGNs shortly after NaAsO2 exposure and then upregulated after a longer time of exposure.	sodium arsenite	91-97	neuroglobin	Rattus norvegicus	0-3
24057451-7	2013	Furthermore, mRNA expression changed more than protein expression and the toxic effect of NaAsO2 on Ngb expression is dose dependent.	sodium arsenite	90-96	neuroglobin	Rattus norvegicus	100-103
24057451-8	2013	Higher Ngb expression was also detected in rat cerebellum, but not in other parts (cerebrum, hippocampus, and midbrain) of the brain exposed to NaAsO2 for 16 weeks.	sodium arsenite	144-150	neuroglobin	Rattus norvegicus	7-10
24057451-9	2013	Taken together, cytotoxic effects of NaAsO2 on rat CGNs is induced at least partly by oxidative stress and Ngb may influence the course of arsenic toxicity in rat CGNs and rat cerebellum.	sodium arsenite	37-43	neuroglobin	Rattus norvegicus	107-110
25087952-0	2014	Hyper-O-GlcNAcylation inhibits the induction of heat shock protein 70 (Hsp 70) by sodium arsenite in HeLa cells.	sodium arsenite	82-97	heat shock protein family A (Hsp70) member 4	Homo sapiens	48-69
25087952-0	2014	Hyper-O-GlcNAcylation inhibits the induction of heat shock protein 70 (Hsp 70) by sodium arsenite in HeLa cells.	sodium arsenite	82-97	heat shock protein family A (Hsp70) member 4	Homo sapiens	71-77
24145059-3	2013	We examined changes in the mRNA level of the lectin-like oxidized LDL (oxLDL) receptor (LOX-1) in a mouse aortic endothelial cell line, END-D, after sodium arsenite (SA) treatment.	sodium arsenite	149-164	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	88-93
24145059-3	2013	We examined changes in the mRNA level of the lectin-like oxidized LDL (oxLDL) receptor (LOX-1) in a mouse aortic endothelial cell line, END-D, after sodium arsenite (SA) treatment.	sodium arsenite	166-168	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	88-93
24145059-4	2013	SA treatment significantly upregulated LOX-1 mRNA expression; this finding was also verified at the protein expression level.	sodium arsenite	0-2	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	39-44
24145059-7	2013	We observed that SA increased the levels of the phosphorylated forms of nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-kappaB)/p65.	sodium arsenite	17-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	140-149
24145059-7	2013	We observed that SA increased the levels of the phosphorylated forms of nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-kappaB)/p65.	sodium arsenite	17-19	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	151-154
24145059-8	2013	SA-induced upregulation of LOX-1 protein expression was clearly prevented by treatment with an antioxidant, N-acetylcysteine (NAC), or an NF-kappaB inhibitor, caffeic acid phenethylester (CAPE).	sodium arsenite	0-2	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	27-32
24145059-8	2013	SA-induced upregulation of LOX-1 protein expression was clearly prevented by treatment with an antioxidant, N-acetylcysteine (NAC), or an NF-kappaB inhibitor, caffeic acid phenethylester (CAPE).	sodium arsenite	0-2	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	138-147
24004876-3	2013	Our results demonstrated that both NaAsO2 and As2O3 caused oxidative stress, genotoxicity, cytotoxicity, cell cycle arrest as well as apoptosis, while As2O3 induced higher production of reactive oxygen species (ROS) with a more remarkable decrease in superoxide dismutase (SOD) activities and intracellular levels of glutathione (GSH) than NaAsO2.	sodium arsenite	35-41	superoxide dismutase 1	Homo sapiens	273-276
23361474-7	2013	RESULTS: In response to sodium arsenite, colon cancer cells (HCT116) increased levels of TRA2beta1 mRNA encoding a functional, full-length Tra2beta with a peak around 6 h without changing its mRNA stability.	sodium arsenite	24-39	transformer 2 beta homolog	Homo sapiens	139-147
23603059-4	2013	In addition, western blot analysis revealed that SA enhances the phosphorylations of c-Jun N-terminal kinases (JNK) and activated protein 1 (AP-1).	sodium arsenite	49-51	mitogen-activated protein kinase 8	Mus musculus	111-114
24113175-3	2013	Blocking DR6 with antagonist antibody 5D10 promotes motor neuron survival in vitro via activation of Akt phosphorylation and inhibition of the caspase 3 signaling pathway, after growth factor withdrawal, sodium arsenite treatment or co-culture with SOD1(G93A) astrocytes.	sodium arsenite	204-219	tumor necrosis factor receptor superfamily, member 21	Mus musculus	9-12
23968725-3	2013	In this study, several important angiogenesis related factors, including cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1alpha (HIF-1alpha), were up-regulated and PI3K/AKT and MAPK signal pathways were activated in human uroepithelial cell line (SV-HUC-1) treated with NaAsO2 (0, 1, 2, 4, 8 or 10muM) for 24h.	sodium arsenite	319-325	hypoxia inducible factor 1 subunit alpha	Homo sapiens	145-176
23968725-3	2013	In this study, several important angiogenesis related factors, including cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1alpha (HIF-1alpha), were up-regulated and PI3K/AKT and MAPK signal pathways were activated in human uroepithelial cell line (SV-HUC-1) treated with NaAsO2 (0, 1, 2, 4, 8 or 10muM) for 24h.	sodium arsenite	319-325	hypoxia inducible factor 1 subunit alpha	Homo sapiens	178-188
23824679-1	2013	In the present study, the role of heme oxygenase (HO)-1 in sodium arsenite (arsenite)-induced neurotoxicity was investigated using primary cultured cortical neurons.	sodium arsenite	59-74	heme oxygenase 1	Homo sapiens	34-55
23603382-7	2013	The mRNA levels of SOD1, CAT, GPx and Txnrd1 were increased significantly (P<0.05) in the combined Na2SeO3+NaAsO2 treatment group.	sodium arsenite	110-116	superoxide dismutase 1	Rattus norvegicus	19-23
23603382-7	2013	The mRNA levels of SOD1, CAT, GPx and Txnrd1 were increased significantly (P<0.05) in the combined Na2SeO3+NaAsO2 treatment group.	sodium arsenite	110-116	catalase	Rattus norvegicus	25-28
23603382-7	2013	The mRNA levels of SOD1, CAT, GPx and Txnrd1 were increased significantly (P<0.05) in the combined Na2SeO3+NaAsO2 treatment group.	sodium arsenite	110-116	thioredoxin reductase 1	Rattus norvegicus	38-44
23603382-8	2013	The expressions of HSP70 and HO-1 were significantly (P<0.05) increased in the NaAsO2 group and reduced in the combined treatment group.	sodium arsenite	82-88	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	19-24
23603382-8	2013	The expressions of HSP70 and HO-1 were significantly (P<0.05) increased in the NaAsO2 group and reduced in the combined treatment group.	sodium arsenite	82-88	heme oxygenase 1	Rattus norvegicus	29-33
21809430-0	2013	Sodium arsenite induced reactive oxygen species generation, nuclear factor (erythroid-2 related) factor 2 activation, heme oxygenase-1 expression, and glutathione elevation in Chang human hepatocytes.	sodium arsenite	0-15	heme oxygenase 1	Homo sapiens	118-134
21809430-3	2013	This study was conducted to evaluate the hepato-cellular Nrf2 and Nrf2-regulated antioxidant reactions of sodium arsenite exposure in Chang human hepatocytes.	sodium arsenite	106-121	NFE2 like bZIP transcription factor 2	Homo sapiens	57-61
21809430-3	2013	This study was conducted to evaluate the hepato-cellular Nrf2 and Nrf2-regulated antioxidant reactions of sodium arsenite exposure in Chang human hepatocytes.	sodium arsenite	106-121	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
23900237-6	2013	The GGT and ALP activities were elevated more than fourfold, in the liver of rats treated with sodium arsenite, while it was reduced almost to half when the sodium arsenit-treated rats were fed fresh V. amgdalina leave extracts The phytochemical constituents of V. amygdalina assayed in this study may be responsible for high radical scavenging of the DPPH free radical observed.	sodium arsenite	95-110	gamma-glutamyltransferase 1	Rattus norvegicus	4-7
24174825-5	2013	The study showed that sodium arsenite significantly (P < 0.05) induced the formation of micronucleated polychromatic erythrocytes and the activities of ALP and GGT when compared with control.	sodium arsenite	22-37	gamma-glutamyltransferase 1	Rattus norvegicus	163-166
23919948-0	2013	Enhanced HSP30 and HSP70 accumulation in Xenopus cells subjected to concurrent sodium arsenite and cadmium chloride stress.	sodium arsenite	79-94	heat shock protein 30E L homeolog	Xenopus laevis	9-14
23919948-0	2013	Enhanced HSP30 and HSP70 accumulation in Xenopus cells subjected to concurrent sodium arsenite and cadmium chloride stress.	sodium arsenite	79-94	heat shock 70kDa protein L homeolog	Xenopus laevis	19-24
23919948-2	2013	The present study examined the effect of simultaneous sodium arsenite and cadmium chloride treatment on the pattern of HSP30 and HSP70 accumulation in A6 kidney epithelial cells of the frog, Xenopus laevis.	sodium arsenite	54-69	heat shock protein 30E L homeolog	Xenopus laevis	119-124
23919948-8	2013	The addition of a mild heat shock further enhanced the accumulation of HSP30 and HSP70 in response to relatively low concentrations of sodium arsenite plus cadmium chloride.	sodium arsenite	135-150	heat shock protein 30E L homeolog	Xenopus laevis	71-76
23919948-8	2013	The addition of a mild heat shock further enhanced the accumulation of HSP30 and HSP70 in response to relatively low concentrations of sodium arsenite plus cadmium chloride.	sodium arsenite	135-150	heat shock 70kDa protein L homeolog	Xenopus laevis	81-86
24351558-1	2013	OBJECTIVE: To observe the chronic combined effects of sodium fluoride and sodium arsenite on the Runx2 and downstream related factors of bone metabolism in SD rats.	sodium arsenite	74-89	RUNX family transcription factor 2	Rattus norvegicus	97-102
23708403-7	2013	Treatment of assay cells ectopically overexpressing the human heat-shock protein 70 (Hsp70) with 15muM sodium arsenite resulted in an additional ~4.5-fold induction of retrotransposition compared with normal assay cells, whereas treatment with 20muM produced a massive cell death.	sodium arsenite	103-118	heat shock protein family A (Hsp70) member 4	Homo sapiens	62-83
23708403-7	2013	Treatment of assay cells ectopically overexpressing the human heat-shock protein 70 (Hsp70) with 15muM sodium arsenite resulted in an additional ~4.5-fold induction of retrotransposition compared with normal assay cells, whereas treatment with 20muM produced a massive cell death.	sodium arsenite	103-118	heat shock protein family A (Hsp70) member 4	Homo sapiens	85-90
23694735-5	2013	Immunoblot analysis of AMPA receptor subunit expression showed that the protein level of GluA1, a specific subunit of the AMPA receptor, was significantly decreased by 1 muM and 2 muM NaAsO2.	sodium arsenite	184-190	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	89-94
23694735-8	2013	These results suggest that the NaAsO2 concentration inducing neurite suppression is lower than the concentration that induces cell death and is the same as the concentration that suppresses GluA1 expression.	sodium arsenite	31-37	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	190-195
23694735-9	2013	Consequently, the suppression of GluA1 expression by NaAsO2 seems at least partly responsible for neurite suppression induced by NaAsO2.	sodium arsenite	53-59	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	33-38
23694735-9	2013	Consequently, the suppression of GluA1 expression by NaAsO2 seems at least partly responsible for neurite suppression induced by NaAsO2.	sodium arsenite	129-135	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	33-38
23603059-6	2013	Finally, SA-induced AT1R expression was found to be prevented both by NAC and specific JNK inhibitor, SP6001325, strongly indicating that AT1R upregulation is a result of the ROS-mediated activation of the JNK signaling pathway.	sodium arsenite	9-11	angiotensin II, type I receptor-associated protein	Mus musculus	20-24
23603059-6	2013	Finally, SA-induced AT1R expression was found to be prevented both by NAC and specific JNK inhibitor, SP6001325, strongly indicating that AT1R upregulation is a result of the ROS-mediated activation of the JNK signaling pathway.	sodium arsenite	9-11	mitogen-activated protein kinase 8	Mus musculus	87-90
23603059-6	2013	Finally, SA-induced AT1R expression was found to be prevented both by NAC and specific JNK inhibitor, SP6001325, strongly indicating that AT1R upregulation is a result of the ROS-mediated activation of the JNK signaling pathway.	sodium arsenite	9-11	angiotensin II, type I receptor-associated protein	Mus musculus	138-142
23603059-6	2013	Finally, SA-induced AT1R expression was found to be prevented both by NAC and specific JNK inhibitor, SP6001325, strongly indicating that AT1R upregulation is a result of the ROS-mediated activation of the JNK signaling pathway.	sodium arsenite	9-11	mitogen-activated protein kinase 8	Mus musculus	206-209
23591579-4	2013	In this study, ATF2 expression was measured in NaAsO(2)-treated human uroepithelial cell line (SV-HUC-1) with 1, 2, 4, 8 and 10 muM concentrations in order to provide some basis data for the study on mechanism of bladder cancer induced by arsenic.	sodium arsenite	47-55	activating transcription factor 2	Homo sapiens	15-19
23591579-4	2013	In this study, ATF2 expression was measured in NaAsO(2)-treated human uroepithelial cell line (SV-HUC-1) with 1, 2, 4, 8 and 10 muM concentrations in order to provide some basis data for the study on mechanism of bladder cancer induced by arsenic.	sodium arsenite	47-55	latexin	Homo sapiens	128-131
23283970-9	2013	Sodium arsenite, an agent that induces oxidative stress, promoted nuclear export of ectopically expressed Nurr1 in HEK293T cells, and the antioxidant N-acetylcysteine rescued from this effect.	sodium arsenite	0-15	nuclear receptor subfamily 4 group A member 2	Homo sapiens	106-111
23472850-7	2013	In this study, we demonstrate that ngfb mRNA is positively modulated in mouse livers after oxidative injury via intraperitoneal injection of 14 mg/kg sodium arsenite, 6 mmol/kg L-buthionine-S-R-sulfoximine (BSO), or 300 mg/kg acetaminophen (APAP).	sodium arsenite	150-165	nerve growth factor	Mus musculus	35-39
23376440-0	2013	Sodium arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through MAPK pathway activation and reactive oxygen species induction.	sodium arsenite	0-15	prostaglandin-endoperoxide synthase 2	Homo sapiens	24-40
23219847-6	2013	Mitochondrial damage and cytochrome-c release induced by sodium arsenite exposure was followed by initiation of the mitochondrial apoptotic pathway in NSC.	sodium arsenite	57-72	cytochrome c, somatic	Homo sapiens	25-37
23219847-9	2013	Overactivation of JNK1 and ERK1/2 and down-regulation of PI3K-AKT activity induced by sodium arsenite were critical factors that strongly affected neuronal differentiation.	sodium arsenite	86-101	mitogen-activated protein kinase 8	Homo sapiens	18-22
23219847-11	2013	Sodium arsenite also negatively affects neuronal differentiation of NSC through overactivation of MEK-ERK and suppression of PI3K-AKT.	sodium arsenite	0-15	mitogen-activated protein kinase kinase 7	Homo sapiens	98-101
23219847-11	2013	Sodium arsenite also negatively affects neuronal differentiation of NSC through overactivation of MEK-ERK and suppression of PI3K-AKT.	sodium arsenite	0-15	mitogen-activated protein kinase 1	Homo sapiens	102-105
23229538-11	2013	Therefore, we thought PEDF played a role in cell apoptosis of liver and brain which induced by sodium arsenite exposure, and the results also demonstrated that Bax and Bcl-2 might be two key targets in the action of PEDF.	sodium arsenite	95-110	serpin family F member 1	Rattus norvegicus	22-26
23555279-3	2013	Activation of SKN-1, either by acute pharmacological treatment with the mitochondrial toxin sodium arsenite or by mutations that cause constitutive SKN-1 activation, results in defects in neuromuscular function.	sodium arsenite	92-107	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	14-19
23143138-0	2013	Sodium arsenite exposure inhibits AKT and Stat3 activation, suppresses self-renewal and induces apoptotic death of embryonic stem cells.	sodium arsenite	0-15	thymoma viral proto-oncogene 1	Mus musculus	34-37
23143138-0	2013	Sodium arsenite exposure inhibits AKT and Stat3 activation, suppresses self-renewal and induces apoptotic death of embryonic stem cells.	sodium arsenite	0-15	signal transducer and activator of transcription 3	Mus musculus	42-47
23143138-4	2013	We demonstrated that the crucial signaling pathway, which was substantially suppressed by sodium arsenite exposure (4 muM) in ESC, was the PI3K-AKT pathway linked with numerous downstream targets that control cell survival and apoptosis.	sodium arsenite	90-105	thymoma viral proto-oncogene 1	Mus musculus	144-147
23143138-5	2013	Furthermore, the whole core transcription factor circuitry that control self-renewal of mouse ESC (Stat3-P-Tyr705, Oct4, Sox2 and Nanog) was strongly down-regulated by sodium arsenite (4 muM) exposure.	sodium arsenite	168-183	signal transducer and activator of transcription 3	Mus musculus	99-104
23143138-5	2013	Furthermore, the whole core transcription factor circuitry that control self-renewal of mouse ESC (Stat3-P-Tyr705, Oct4, Sox2 and Nanog) was strongly down-regulated by sodium arsenite (4 muM) exposure.	sodium arsenite	168-183	POU domain, class 5, transcription factor 1, related sequence 1	Mus musculus	115-119
23143138-5	2013	Furthermore, the whole core transcription factor circuitry that control self-renewal of mouse ESC (Stat3-P-Tyr705, Oct4, Sox2 and Nanog) was strongly down-regulated by sodium arsenite (4 muM) exposure.	sodium arsenite	168-183	SRY (sex determining region Y)-box 2	Mus musculus	121-125
23143138-5	2013	Furthermore, the whole core transcription factor circuitry that control self-renewal of mouse ESC (Stat3-P-Tyr705, Oct4, Sox2 and Nanog) was strongly down-regulated by sodium arsenite (4 muM) exposure.	sodium arsenite	168-183	Nanog homeobox	Mus musculus	130-135
23143138-7	2013	In contrast to mouse ESC with very low endogenous IL6, mouse neural stem/precursor cells (C17.2 clone immortalized by v-myc) with high endogenous production of IL6 exhibited a strong resistance to cytotoxic effects of sodium arsenite that could be decreased by inhibitory anti-IL6 antibody or Stat3 inhibition.	sodium arsenite	218-233	interleukin 6	Mus musculus	160-163
23143138-7	2013	In contrast to mouse ESC with very low endogenous IL6, mouse neural stem/precursor cells (C17.2 clone immortalized by v-myc) with high endogenous production of IL6 exhibited a strong resistance to cytotoxic effects of sodium arsenite that could be decreased by inhibitory anti-IL6 antibody or Stat3 inhibition.	sodium arsenite	218-233	interleukin 6	Mus musculus	160-163
23143138-8	2013	In summary, our data demonstrated suppression of self-renewal and induction of apoptosis in mouse ESC by sodium arsenite exposure, which was further accelerated due to simultaneous inhibition of the protective PI3K-AKT and Stat3-dependent pathways.	sodium arsenite	105-120	thymoma viral proto-oncogene 1	Mus musculus	215-218
23143138-8	2013	In summary, our data demonstrated suppression of self-renewal and induction of apoptosis in mouse ESC by sodium arsenite exposure, which was further accelerated due to simultaneous inhibition of the protective PI3K-AKT and Stat3-dependent pathways.	sodium arsenite	105-120	signal transducer and activator of transcription 3	Mus musculus	223-228
23229538-11	2013	Therefore, we thought PEDF played a role in cell apoptosis of liver and brain which induced by sodium arsenite exposure, and the results also demonstrated that Bax and Bcl-2 might be two key targets in the action of PEDF.	sodium arsenite	95-110	serpin family F member 1	Rattus norvegicus	216-220
24368942-7	2013	Sodium arsenite significantly (P < 0.05) suppressed the glutathione peroxidase, catalase, superoxide dismutase activities with simultaneous induction of lipid peroxidation.	sodium arsenite	0-15	catalase	Rattus norvegicus	83-91
23165982-1	2013	This study examined whether S100A8 and S100A9, which comprise a complex             called calprotectin, are upregulated by exposure to sodium arsenite [As(III)]             in nine lines of human-derived cells.	sodium arsenite	136-151	S100 calcium binding protein A8	Homo sapiens	28-34
23165982-1	2013	This study examined whether S100A8 and S100A9, which comprise a complex             called calprotectin, are upregulated by exposure to sodium arsenite [As(III)]             in nine lines of human-derived cells.	sodium arsenite	136-151	S100 calcium binding protein A9	Homo sapiens	39-45