PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2912370-4 1989 Using radioimmunoassay, it was shown that other agents known to increase the testicular heme oxygenase, sodium arsenate and sodium arsenite, also increased the microsomal content of HO-1. sodium arsenite 124-139 heme oxygenase 1 Rattus norvegicus 182-186 2974799-2 1988 In vivo, intron-containing transcripts of the hsp27 gene accumulate in cells stressed by heat or sodium arsenite. sodium arsenite 97-112 heat shock protein family B (small) member 1 Homo sapiens 46-51 3409220-3 1988 The library was constructed from mRNA extracted from the cells treated with sodium arsenite, which stimulates the p32 expression most effectively among various agents so far tested. sodium arsenite 76-91 complement component 1, q subcomponent binding protein Mus musculus 114-117 3409220-5 1988 RNA blot analysis has shown that p32 mRNA is induced as early as 0.5 h after the addition of 12-O-tetradecanoyl-phorbol-13-acetate or sodium arsenite. sodium arsenite 134-149 complement component 1, q subcomponent binding protein Mus musculus 33-36 2457504-1 1988 Challenge of mammalian cells with heavy metals or sulfhydryl-reactive agents including sodium arsenite induces the de novo synthesis of a 32-/34-kDa stress protein (p32) (M. M. Caltabiano, T. P. Koestler, G. Poste, and R. G. Greig (1986) J. Biol. sodium arsenite 87-102 inhibitor of growth family member 2 Homo sapiens 165-168 2457504-4 1988 Here we report that antibody prepared against p32/p34 purified from human A375 melanoma cells immunoprecipitated an antigen of similar molecular mass from a panel of human, rat, and murine cells following challenge with sodium arsenite. sodium arsenite 220-235 inhibitor of growth family member 2 Homo sapiens 46-49 2457504-4 1988 Here we report that antibody prepared against p32/p34 purified from human A375 melanoma cells immunoprecipitated an antigen of similar molecular mass from a panel of human, rat, and murine cells following challenge with sodium arsenite. sodium arsenite 220-235 alpha and gamma adaptin binding protein Homo sapiens 50-53 3196465-7 1988 In conclusion, heat shock and sodium arsenite induce a similar set of HSPs but maximum synthesis of the HSP is temporally separated by 12-24 h. sodium arsenite 30-45 heat shock 70kDa protein L homeolog Xenopus laevis 70-73 3196465-1 1988 Continuous exposure of a Xenopus laevis kidney epithelial cell line, A6, to either heat shock (33 degrees C) or sodium arsenite (50 microM) resulted in transient but markedly different temporal patterns of heat-shock protein (HSP) synthesis and HSP 70 and 30 mRNA accumulation. sodium arsenite 112-127 heat shock 70kDa protein L homeolog Xenopus laevis 206-224 3196465-1 1988 Continuous exposure of a Xenopus laevis kidney epithelial cell line, A6, to either heat shock (33 degrees C) or sodium arsenite (50 microM) resulted in transient but markedly different temporal patterns of heat-shock protein (HSP) synthesis and HSP 70 and 30 mRNA accumulation. sodium arsenite 112-127 heat shock 70kDa protein L homeolog Xenopus laevis 226-229 3196465-1 1988 Continuous exposure of a Xenopus laevis kidney epithelial cell line, A6, to either heat shock (33 degrees C) or sodium arsenite (50 microM) resulted in transient but markedly different temporal patterns of heat-shock protein (HSP) synthesis and HSP 70 and 30 mRNA accumulation. sodium arsenite 112-127 heat shock 70kDa protein L homeolog Xenopus laevis 245-248 3196465-2 1988 Heat-shock-induced synthesis of HSPs was detectable within 1 h and reached maximum levels by 2-3 h. While sodium arsenite induced the synthesis of some HSPs within 1 h, maximal HSP synthesis did not occur until 12 h. The pattern of HSP 70 and 30 mRNA accumulation was similar to the response observed at the protein level. sodium arsenite 106-121 heat shock 70kDa protein L homeolog Xenopus laevis 32-35 3196465-2 1988 Heat-shock-induced synthesis of HSPs was detectable within 1 h and reached maximum levels by 2-3 h. While sodium arsenite induced the synthesis of some HSPs within 1 h, maximal HSP synthesis did not occur until 12 h. The pattern of HSP 70 and 30 mRNA accumulation was similar to the response observed at the protein level. sodium arsenite 106-121 heat shock 70kDa protein L homeolog Xenopus laevis 152-155 3412774-0 1988 c-fos mRNA levels are increased by the cellular stressors, heat shock and sodium arsenite. sodium arsenite 74-89 FBJ osteosarcoma oncogene Mus musculus 0-5 3412774-3 1988 Our findings demonstrate that c-fos mRNA levels increase transiently under conditions of heat stress or sodium arsenite treatment which induce expression of hsp70 mRNA in cultured cell lines. sodium arsenite 104-119 FBJ osteosarcoma oncogene Mus musculus 30-35 3412774-3 1988 Our findings demonstrate that c-fos mRNA levels increase transiently under conditions of heat stress or sodium arsenite treatment which induce expression of hsp70 mRNA in cultured cell lines. sodium arsenite 104-119 heat shock protein 1B Mus musculus 157-162 3412774-7 1988 A comparison of relative rates of protein synthesis and c-fos mRNA levels during either heat shock or sodium arsenite treatment suggests that the transient suppression of protein synthesis accompanying these treatments may be one factor responsible for the observed c-fos mRNA induction. sodium arsenite 102-117 FBJ osteosarcoma oncogene Mus musculus 56-61 3412774-7 1988 A comparison of relative rates of protein synthesis and c-fos mRNA levels during either heat shock or sodium arsenite treatment suggests that the transient suppression of protein synthesis accompanying these treatments may be one factor responsible for the observed c-fos mRNA induction. sodium arsenite 102-117 FBJ osteosarcoma oncogene Mus musculus 266-271 3597553-1 1987 After sodium arsenite (100 microM) treatment, the synthesis of three major heat shock protein families (HSPs; Mr = 110,000, 87,000, and 70,000), as studied with one-dimensional gels, was enhanced twofold relative to that of unheated cells. sodium arsenite 6-21 10 kDa heat shock protein, mitochondrial Cricetulus griseus 75-93 3606855-1 1987 Heat shock protein (HSP) synthesis was studied in the Xenopus epithelial cell line A6 in response to heat and sodium arsenite, either singly or together. sodium arsenite 110-125 heat shock 70kDa protein L homeolog Xenopus laevis 0-18 3606855-1 1987 Heat shock protein (HSP) synthesis was studied in the Xenopus epithelial cell line A6 in response to heat and sodium arsenite, either singly or together. sodium arsenite 110-125 heat shock 70kDa protein L homeolog Xenopus laevis 20-23 3606855-3 1987 In cultures exposed to 10 microM sodium arsenite at 30 degrees C, HSP synthesis in the 68- to 73-kDa and 29- to 31-kDa regions was much greater than the HSP synthesis in response to each treatment individually. sodium arsenite 33-48 heat shock 70kDa protein L homeolog Xenopus laevis 66-69 3606855-3 1987 In cultures exposed to 10 microM sodium arsenite at 30 degrees C, HSP synthesis in the 68- to 73-kDa and 29- to 31-kDa regions was much greater than the HSP synthesis in response to each treatment individually. sodium arsenite 33-48 heat shock 70kDa protein L homeolog Xenopus laevis 153-156 3606855-6 1987 Sodium arsenite (10-100 microM) also induced the accumulation of both HSP 70 and 30 mRNAs. sodium arsenite 0-15 heat shock 70kDa protein L homeolog Xenopus laevis 70-76 3606855-7 1987 Finally, a mild heat shock (30 degrees C) plus a low concentration of sodium arsenite (10 microM) acted synergistically on HSP 70 and 30 mRNA accumulation in A6 cells. sodium arsenite 70-85 heat shock 70kDa protein L homeolog Xenopus laevis 123-126 3606855-8 1987 Thus sodium arsenite and heat act synergistically at the level of both HSP synthesis and HSP mRNA accumulation. sodium arsenite 5-20 heat shock 70kDa protein L homeolog Xenopus laevis 71-74 3606855-8 1987 Thus sodium arsenite and heat act synergistically at the level of both HSP synthesis and HSP mRNA accumulation. sodium arsenite 5-20 heat shock 70kDa protein L homeolog Xenopus laevis 89-92 3828114-3 1987 Exposure of Xenopus laevis embryos to other stressors, such as sodium arsenite or ethanol, also induced a developmental stage-dependent accumulation of hsp 70 mRNA. sodium arsenite 63-78 heat shock 70kDa protein L homeolog Xenopus laevis 152-158 3754488-3 1986 p32 might be one of the heat shock proteins because its synthesis was also stimulated by heat shock or sodium arsenite. sodium arsenite 103-118 complement component 1, q subcomponent binding protein Mus musculus 0-3 3753897-1 1986 Pretreatment of sodium arsenite reduces hypoxanthine-guanine phosphoribosyltransferase mutagenicity and overcomes the inhibition of mitosis and cell proliferation but has no apparent effect on the cytotoxicity and clastogenicity in methyl methanesulfonate (MMS)-treated Chinese hamster ovary cells. sodium arsenite 16-31 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 40-86 3753897-2 1986 Posttreatment of sodium arsenite drastically increases the cytotoxicity, clastogenicity, hypoxanthine-guanine phosphoribosyltransferase mutagenicity, and inhibition of mitosis and cell proliferation induced by MMS. sodium arsenite 17-32 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 89-135 3753679-4 1986 Furthermore, the mutagenicity of cis-Pt(II) at the hypoxanthine-guanine phosphoribosyl transferase locus is also potentiated by sodium arsenite in CHO cells. sodium arsenite 128-143 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 51-98 6424670-2 1984 Here, we demonstrate that this methylation can be modulated by sodium arsenite, a chemical that increases the synthesis of hsp70. sodium arsenite 63-78 heat shock protein family A (Hsp70) member 2 Gallus gallus 123-128 6841458-0 1983 Induction of thermotolerance and enhanced heat shock protein synthesis in Chinese hamster fibroblasts by sodium arsenite and by ethanol. sodium arsenite 105-120 10 kDa heat shock protein, mitochondrial Cricetulus griseus 42-60 6841458-3 1983 A causative relationship between heat shock protein synthesis and development of thermotolerance would imply that agents known to induce heat shock protein synthesis, such as sodium arsenite, also induce thermotolerance. sodium arsenite 175-190 10 kDa heat shock protein, mitochondrial Cricetulus griseus 33-51 6841458-3 1983 A causative relationship between heat shock protein synthesis and development of thermotolerance would imply that agents known to induce heat shock protein synthesis, such as sodium arsenite, also induce thermotolerance. sodium arsenite 175-190 10 kDa heat shock protein, mitochondrial Cricetulus griseus 137-155 6114827-5 1981 Furthermore, disulfides [insulin, glutathione disulfide, L-cystine, and 5,5"-dithiobis (2-nitrobenzoic acid)] known to interact with thioredoxin-dependent enzyme systems inhibited sulindac reduction, as did sodium arsenite, a known inhibitor of thioredoxin reductase. sodium arsenite 207-222 thioredoxin 1 Rattus norvegicus 133-144 818137-8 1976 The bovine pancreatic lipase appeared to contain sulfhydryl groups which may be essential for the lipolytic activity since p-chloromercuribenzoate, N-ethylmaleimide, sodium arsenite, and iodoacetate inhibited the enzyme. sodium arsenite 166-181 pancreatic lipase Bos taurus 11-28 30907158-10 2021 Treatment with GA remarkably improved SA-induced alteration of hematological and histopathological parameters; these protective effects were associated with the reduction of SA-induced elevation of MDA, IL-1beta and NO levels as well as reduction of GSH level and GPx, SOD and CAT activity. sodium arsenite 174-176 interleukin 1 beta Rattus norvegicus 203-211 30907158-10 2021 Treatment with GA remarkably improved SA-induced alteration of hematological and histopathological parameters; these protective effects were associated with the reduction of SA-induced elevation of MDA, IL-1beta and NO levels as well as reduction of GSH level and GPx, SOD and CAT activity. sodium arsenite 174-176 catalase Rattus norvegicus 277-280 34006163-0 2021 Ameliorative role of inducible nitric oxide synthase inhibitors against sodium arsenite-induced renal and hepatic dysfunction in rats. sodium arsenite 72-87 nitric oxide synthase 2 Rattus norvegicus 21-52 34006163-2 2021 The present study explored the role of inducible nitric oxide synthase (iNOS) inhibitors against sodium arsenite-induced renal and hepatic dysfunction in rats. sodium arsenite 97-112 nitric oxide synthase 2 Rattus norvegicus 39-70 34006163-2 2021 The present study explored the role of inducible nitric oxide synthase (iNOS) inhibitors against sodium arsenite-induced renal and hepatic dysfunction in rats. sodium arsenite 97-112 nitric oxide synthase 2 Rattus norvegicus 72-76 34006163-13 2021 Hence, it is concluded that iNOS inhibitors attenuate sodium arsenite-induced renal and hepatic dysfunction in rats. sodium arsenite 54-69 nitric oxide synthase 2 Rattus norvegicus 28-32 33609750-4 2021 In our study, we found that the expression of lncRNA DICER1-AS1 was significantly inhibited by sodium arsenite in a dose-dependent manner. sodium arsenite 95-110 dicer 1, ribonuclease III Homo sapiens 53-59 33609750-4 2021 In our study, we found that the expression of lncRNA DICER1-AS1 was significantly inhibited by sodium arsenite in a dose-dependent manner. sodium arsenite 95-110 prostaglandin D2 receptor Homo sapiens 60-63 33621689-2 2021 The present study demonstrated that prolonged exposure to sodium arsenite at low micromolar range (1-10 muM) reduced Tau 1 (recognizing dephosphorylated tau at residues 189-207) and elevated pS202 tau in differentiated human neuroblastoma SH-SY5Y cells indicating that arsenic increases tau phosphorylation in neurons. sodium arsenite 58-73 microtubule associated protein tau Homo sapiens 153-156 33621689-2 2021 The present study demonstrated that prolonged exposure to sodium arsenite at low micromolar range (1-10 muM) reduced Tau 1 (recognizing dephosphorylated tau at residues 189-207) and elevated pS202 tau in differentiated human neuroblastoma SH-SY5Y cells indicating that arsenic increases tau phosphorylation in neurons. sodium arsenite 58-73 microtubule associated protein tau Homo sapiens 197-200 33621689-3 2021 Sodium arsenite elevated GSK3beta kinase activity, while GSK3 inhibitors, BIO, SB216763, and lithium, reversed the Tau 1 reduction by sodium arsenite. sodium arsenite 0-15 glycogen synthase kinase 3 alpha Homo sapiens 25-33 33621689-3 2021 Sodium arsenite elevated GSK3beta kinase activity, while GSK3 inhibitors, BIO, SB216763, and lithium, reversed the Tau 1 reduction by sodium arsenite. sodium arsenite 134-149 microtubule associated protein tau Homo sapiens 115-118 33621689-4 2021 Additionally, sodium arsenite increased levels of active phosphorylation of ERK1/2, and inhibition of ERK1/2 by U0126 partially improved the Tau1 reduction. sodium arsenite 14-29 mitogen-activated protein kinase 3 Homo sapiens 76-82 33621689-6 2021 Furthermore, sodium arsenite augmented tau phosphorylation in the membrane and cytosolic fractions. sodium arsenite 13-28 microtubule associated protein tau Homo sapiens 39-42 33621689-7 2021 Inductions of GSK3 activity by sodium arsenite treatment were observed in the membrane fraction, as evidenced by a reduction of beta-catenin, a protein signaled for degradation following phosphorylation by GSK3. sodium arsenite 31-46 catenin beta 1 Homo sapiens 128-140 33621689-8 2021 An enhancement of ERK1/2 phosphorylation by sodium arsenite was also witnessed in the cytosol. sodium arsenite 44-59 mitogen-activated protein kinase 3 Homo sapiens 18-24 33621689-9 2021 Additionally, sodium arsenite increased insoluble tau aggregation. sodium arsenite 14-29 microtubule associated protein tau Homo sapiens 50-53 33854955-6 2021 Sodium arsenite caused mild expression of BCL-2 protein> NF-Kb = p53 in the kidney of rats. sodium arsenite 0-15 BCL2, apoptosis regulator Rattus norvegicus 42-47 33854955-6 2021 Sodium arsenite caused mild expression of BCL-2 protein> NF-Kb = p53 in the kidney of rats. sodium arsenite 0-15 RELA proto-oncogene, NF-kB subunit Rattus norvegicus 57-62 33854955-6 2021 Sodium arsenite caused mild expression of BCL-2 protein> NF-Kb = p53 in the kidney of rats. sodium arsenite 0-15 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 65-68 33388378-7 2021 Subsequent results showed that TET1 and TET2 siRNA led to further inhibition of genome 5hmC and a higher level of oxidative stress in NaAsO2-treated HBE cells. sodium arsenite 134-140 tet methylcytosine dioxygenase 1 Homo sapiens 31-35 33388378-7 2021 Subsequent results showed that TET1 and TET2 siRNA led to further inhibition of genome 5hmC and a higher level of oxidative stress in NaAsO2-treated HBE cells. sodium arsenite 134-140 tet methylcytosine dioxygenase 2 Homo sapiens 40-44 33497687-8 2021 NaAsO2-treatment resulted in a significant increase in lipid peroxidation (LPO), inducible nitric oxide synthetase (iNOs), and NO levels, with a decrease in the levels of both enzymatic (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and non-enzymatic (glutathione) antioxidant markers. sodium arsenite 0-6 nitric oxide synthase 2, inducible Mus musculus 81-114 33497687-8 2021 NaAsO2-treatment resulted in a significant increase in lipid peroxidation (LPO), inducible nitric oxide synthetase (iNOs), and NO levels, with a decrease in the levels of both enzymatic (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and non-enzymatic (glutathione) antioxidant markers. sodium arsenite 0-6 nitric oxide synthase 2, inducible Mus musculus 116-120 33497687-8 2021 NaAsO2-treatment resulted in a significant increase in lipid peroxidation (LPO), inducible nitric oxide synthetase (iNOs), and NO levels, with a decrease in the levels of both enzymatic (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and non-enzymatic (glutathione) antioxidant markers. sodium arsenite 0-6 catalase Mus musculus 209-217 33497687-8 2021 NaAsO2-treatment resulted in a significant increase in lipid peroxidation (LPO), inducible nitric oxide synthetase (iNOs), and NO levels, with a decrease in the levels of both enzymatic (superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase) and non-enzymatic (glutathione) antioxidant markers. sodium arsenite 0-6 glutathione reductase Mus musculus 247-268 33884178-0 2021 Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARgamma pathway against oxidative injury in mice hippocampus. sodium arsenite 0-15 nuclear factor, erythroid derived 2, like 2 Mus musculus 114-118 33884178-0 2021 Sodium arsenite induces spatial learning and memory impairment associated with oxidative stress and activates the Nrf2/PPARgamma pathway against oxidative injury in mice hippocampus. sodium arsenite 0-15 peroxisome proliferator activated receptor gamma Mus musculus 119-128 32930475-3 2021 In this study, we found that the AS3MT was overexpressed in arsenic exposed population, non-small cell lung cancer (NSCLC) tissues, and A549 cells with sodium arsenite (NaAsO2 ) treatment for 48 hours. sodium arsenite 152-167 arsenite methyltransferase Homo sapiens 33-38 32930475-3 2021 In this study, we found that the AS3MT was overexpressed in arsenic exposed population, non-small cell lung cancer (NSCLC) tissues, and A549 cells with sodium arsenite (NaAsO2 ) treatment for 48 hours. sodium arsenite 169-175 arsenite methyltransferase Homo sapiens 33-38 33026618-12 2021 In addition, sodium arsenite-induced alteration in hepatic parameters (serum aspartate aminotransferase, alanine transferase, alkaline phosphatase, bilirubin), oxidative stress and histological changes were abrogated by bosentan treatment in rats. sodium arsenite 13-28 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 77-103 32776539-0 2021 IRE1alpha/NOX4 signaling pathway mediates ROS-dependent activation of hepatic stellate cells in NaAsO2 -induced liver fibrosis. sodium arsenite 96-102 NADPH oxidase 4 Rattus norvegicus 10-14 33387887-5 2021 Time-lapse imaging showed that TDP-43 aggregates appeared in the nucleus within 30 min of treatment with sodium arsenite. sodium arsenite 105-120 TAR DNA binding protein Homo sapiens 31-37 33039867-0 2021 ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner. sodium arsenite 45-51 tumor protein p53 Homo sapiens 150-153 33039867-6 2021 Nanog, SOX-2 and ALDH1A1, three markers of cancer stemness, were upregulated in NaAsO2-exposed PC-3 spheres. sodium arsenite 80-86 Nanog homeobox Homo sapiens 0-5 33039867-6 2021 Nanog, SOX-2 and ALDH1A1, three markers of cancer stemness, were upregulated in NaAsO2-exposed PC-3 spheres. sodium arsenite 80-86 SRY-box transcription factor 2 Homo sapiens 7-12 33039867-6 2021 Nanog, SOX-2 and ALDH1A1, three markers of cancer stemness, were upregulated in NaAsO2-exposed PC-3 spheres. sodium arsenite 80-86 aldehyde dehydrogenase 1 family member A1 Homo sapiens 17-24 33039867-8 2021 Histone H2AX phosphorylation on Ser139, an indicator for DNA double-strand break, was upregulated in NaAsO2-exposed DU145 and PC-3 cells. sodium arsenite 101-107 H2A.X variant histone Homo sapiens 0-12 33039867-9 2021 ATM phosphorylation on Ser1981, a key sensor of genotoxic stress, was rapidly elevated in NaAsO2-exposed DU145 cells. sodium arsenite 90-96 ATM serine/threonine kinase Homo sapiens 0-3 33039867-10 2021 Phosphor-p53, a downstream molecule of ATM signaling, and p21, a direct target of p53, were upregulated in NaAsO2-exposed DU145 cells. sodium arsenite 107-113 tumor protein p53 Homo sapiens 9-12 33039867-10 2021 Phosphor-p53, a downstream molecule of ATM signaling, and p21, a direct target of p53, were upregulated in NaAsO2-exposed DU145 cells. sodium arsenite 107-113 ATM serine/threonine kinase Homo sapiens 39-42 33039867-10 2021 Phosphor-p53, a downstream molecule of ATM signaling, and p21, a direct target of p53, were upregulated in NaAsO2-exposed DU145 cells. sodium arsenite 107-113 H3 histone pseudogene 16 Homo sapiens 58-61 33039867-10 2021 Phosphor-p53, a downstream molecule of ATM signaling, and p21, a direct target of p53, were upregulated in NaAsO2-exposed DU145 cells. sodium arsenite 107-113 tumor protein p53 Homo sapiens 82-85 33039867-11 2021 Unexpectedly, p21 was also elevated in NaAsO2-exposed p53-null PC-3 cells. sodium arsenite 39-45 H3 histone pseudogene 16 Homo sapiens 14-17 33039867-11 2021 Unexpectedly, p21 was also elevated in NaAsO2-exposed p53-null PC-3 cells. sodium arsenite 39-45 tumor protein p53 Homo sapiens 54-57 33039867-12 2021 Antioxidant NAC alleviated NaAsO2-induced ATM phosphorylation, cell cycle arrest, and subsequent stemness enhancement and chemoresistance in both DU145 and PC-3 cells. sodium arsenite 27-33 synuclein alpha Homo sapiens 12-15 33039867-12 2021 Antioxidant NAC alleviated NaAsO2-induced ATM phosphorylation, cell cycle arrest, and subsequent stemness enhancement and chemoresistance in both DU145 and PC-3 cells. sodium arsenite 27-33 ATM serine/threonine kinase Homo sapiens 42-45 33039867-13 2021 These results suggest that ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner. sodium arsenite 72-78 tumor protein p53 Homo sapiens 177-180 33242462-5 2021 Moreover, NaAsO2 toxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2-related factor 2) gene expression level, and elevations in malondialdehyde. sodium arsenite 10-16 catalase Mus musculus 73-76 33242462-5 2021 Moreover, NaAsO2 toxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2-related factor 2) gene expression level, and elevations in malondialdehyde. sodium arsenite 10-16 peroxiredoxin 6 pseudogene 2 Mus musculus 78-81 33242462-5 2021 Moreover, NaAsO2 toxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2-related factor 2) gene expression level, and elevations in malondialdehyde. sodium arsenite 10-16 nuclear receptor subfamily 3, group C, member 1 Mus musculus 83-85 33242462-5 2021 Moreover, NaAsO2 toxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2-related factor 2) gene expression level, and elevations in malondialdehyde. sodium arsenite 10-16 nuclear factor, erythroid derived 2, like 2 Mus musculus 116-120 33242462-5 2021 Moreover, NaAsO2 toxicity evoked exhaustion of antioxidant markers (SOD, CAT, GPx, GR, and GSH), down-regulation of Nrf2 (nuclear factor erythroid 2-related factor 2) gene expression level, and elevations in malondialdehyde. sodium arsenite 10-16 nuclear factor, erythroid derived 2, like 2 Mus musculus 122-165 33242462-7 2021 Immunohistochemical analysis of testis sections of NaAsO2-treated mice showed high caspase-3 expression. sodium arsenite 51-57 caspase 3 Mus musculus 83-92 32882370-4 2021 We used a sodium arsenite-induced cellular stress model to investigate the role of hypusinated eIF5A (eIF5AHypK50) in governing TDP-43 cytoplasmic mislocalization and accumulation in stress granule. sodium arsenite 10-25 eukaryotic translation initiation factor 5A Homo sapiens 95-100 32882370-4 2021 We used a sodium arsenite-induced cellular stress model to investigate the role of hypusinated eIF5A (eIF5AHypK50) in governing TDP-43 cytoplasmic mislocalization and accumulation in stress granule. sodium arsenite 10-25 eukaryotic translation initiation factor 5A Homo sapiens 102-113 32882370-4 2021 We used a sodium arsenite-induced cellular stress model to investigate the role of hypusinated eIF5A (eIF5AHypK50) in governing TDP-43 cytoplasmic mislocalization and accumulation in stress granule. sodium arsenite 10-25 TAR DNA binding protein Homo sapiens 128-134 32816178-8 2021 The expression of HOTAIR was considerably high in the presence of NaAsO2 and MMA but showed no difference in DMA compared with control group. sodium arsenite 66-72 HOX transcript antisense RNA Homo sapiens 18-24 32816178-9 2021 And LincRNA-p21 expression was increased in the presence of NaAsO2, MMA, and DMA. sodium arsenite 60-66 tumor protein p53 pathway corepressor 1 Homo sapiens 4-15 32816178-11 2021 Compared with the control group, treatment of A549 cells with NaAsO2/S-adenosylmethionine (SAM) and NaAsO2/glutathione (GSH) combination increased HOTAIR and LincRNA-p21 expression. sodium arsenite 62-68 HOX transcript antisense RNA Homo sapiens 147-153 32816178-11 2021 Compared with the control group, treatment of A549 cells with NaAsO2/S-adenosylmethionine (SAM) and NaAsO2/glutathione (GSH) combination increased HOTAIR and LincRNA-p21 expression. sodium arsenite 62-68 tumor protein p53 pathway corepressor 1 Homo sapiens 158-169 32816178-11 2021 Compared with the control group, treatment of A549 cells with NaAsO2/S-adenosylmethionine (SAM) and NaAsO2/glutathione (GSH) combination increased HOTAIR and LincRNA-p21 expression. sodium arsenite 100-106 HOX transcript antisense RNA Homo sapiens 147-153 32816178-11 2021 Compared with the control group, treatment of A549 cells with NaAsO2/S-adenosylmethionine (SAM) and NaAsO2/glutathione (GSH) combination increased HOTAIR and LincRNA-p21 expression. sodium arsenite 100-106 tumor protein p53 pathway corepressor 1 Homo sapiens 158-169 32816178-12 2021 The expression of LincRNA-p21 in combination of NaAsO2/GSH was significantly decreased compared with NaAsO2 alone. sodium arsenite 48-54 tumor protein p53 pathway corepressor 1 Homo sapiens 18-29 32816178-12 2021 The expression of LincRNA-p21 in combination of NaAsO2/GSH was significantly decreased compared with NaAsO2 alone. sodium arsenite 101-107 tumor protein p53 pathway corepressor 1 Homo sapiens 18-29 33327938-11 2020 RESULTS: We detected RFP+ neurons and glia in the brains of postnatal mice that had been prenatally exposed to alcohol or sodium arsenite. sodium arsenite 122-137 tripartite motif-containing 27 Mus musculus 21-24 33327938-12 2020 In animals prenatally exposed to sodium arsenite, we also detected reduced excitability in RFP+ cortical neurons. sodium arsenite 33-48 tripartite motif-containing 27 Mus musculus 91-94 32844245-4 2020 We demonstrate that continuous exposure of HepaRG cells to 1 microM sodium arsenite (NaAsO2) for 14 days resulted in substantial cytosine DNA demethylation and hypermethylation across the genome, among which the claudin 14 (CLDN14) gene was hypermethylated and the most down-regulated gene. sodium arsenite 68-83 claudin 14 Homo sapiens 212-222 32844245-4 2020 We demonstrate that continuous exposure of HepaRG cells to 1 microM sodium arsenite (NaAsO2) for 14 days resulted in substantial cytosine DNA demethylation and hypermethylation across the genome, among which the claudin 14 (CLDN14) gene was hypermethylated and the most down-regulated gene. sodium arsenite 68-83 claudin 14 Homo sapiens 224-230 32844245-4 2020 We demonstrate that continuous exposure of HepaRG cells to 1 microM sodium arsenite (NaAsO2) for 14 days resulted in substantial cytosine DNA demethylation and hypermethylation across the genome, among which the claudin 14 (CLDN14) gene was hypermethylated and the most down-regulated gene. sodium arsenite 85-91 claudin 14 Homo sapiens 212-222 32844245-4 2020 We demonstrate that continuous exposure of HepaRG cells to 1 microM sodium arsenite (NaAsO2) for 14 days resulted in substantial cytosine DNA demethylation and hypermethylation across the genome, among which the claudin 14 (CLDN14) gene was hypermethylated and the most down-regulated gene. sodium arsenite 85-91 claudin 14 Homo sapiens 224-230 33025330-9 2020 In WT or MT hSOD1-transfected HEK293 and NSC-34 cells, the formation of TIA-1-positive stress granules was delayed in MTSOD1 by sodium arsenite treatment. sodium arsenite 128-143 superoxide dismutase 1 Homo sapiens 12-17 33025330-9 2020 In WT or MT hSOD1-transfected HEK293 and NSC-34 cells, the formation of TIA-1-positive stress granules was delayed in MTSOD1 by sodium arsenite treatment. sodium arsenite 128-143 cytotoxic granule-associated RNA binding protein 1 Mus musculus 72-77 33025330-9 2020 In WT or MT hSOD1-transfected HEK293 and NSC-34 cells, the formation of TIA-1-positive stress granules was delayed in MTSOD1 by sodium arsenite treatment. sodium arsenite 128-143 superoxide dismutase 1, soluble Mus musculus 118-124 33053406-2 2020 Considering that arsenic has the potential to inhibit autophagic flux, it was hypothesized that arsenite (NaAsO2) may interplay with LRRK2 and alpha-Synuclein, affecting their phosphorylation in brain regions prone to neurodegeneration. sodium arsenite 106-112 leucine-rich repeat kinase 2 Mus musculus 133-138 33053406-2 2020 Considering that arsenic has the potential to inhibit autophagic flux, it was hypothesized that arsenite (NaAsO2) may interplay with LRRK2 and alpha-Synuclein, affecting their phosphorylation in brain regions prone to neurodegeneration. sodium arsenite 106-112 synuclein, alpha Mus musculus 143-158 33256086-0 2020 Anti-Tumor Effects of Sodium Meta-Arsenite in Glioblastoma Cells with Higher Akt Activities. sodium arsenite 22-42 AKT serine/threonine kinase 1 Homo sapiens 77-80 33256086-3 2020 Sodium meta-arsenite, KML001 is an orally bioavailable, water-soluble, and trivalent arsenical and it shows antitumoral effects in several solid tumor cells via inhibiting oncogenic signaling, including Akt and MAPK. sodium arsenite 22-28 AKT serine/threonine kinase 1 Homo sapiens 203-206 33256086-4 2020 Here, we evaluated the effect of sodium meta-arsenite, KML001, on the growth of human glioblastoma cell lines with different PTEN expression status and Akt activation, including PTEN-deficient cells (U87-MG and U251) and PTEN-positive cells (LN229). sodium arsenite 33-53 phosphatase and tensin homolog Homo sapiens 125-129 33256086-4 2020 Here, we evaluated the effect of sodium meta-arsenite, KML001, on the growth of human glioblastoma cell lines with different PTEN expression status and Akt activation, including PTEN-deficient cells (U87-MG and U251) and PTEN-positive cells (LN229). sodium arsenite 33-53 AKT serine/threonine kinase 1 Homo sapiens 152-155 33256086-5 2020 The growth-inhibitory effect of KML001 was stronger in U87-MG and U251 cells, which exhibited higher Akt activity than LN229 cells. sodium arsenite 32-38 AKT serine/threonine kinase 1 Homo sapiens 101-104 32544768-5 2020 Additionally, NaAsO2 upregulated the level of oxidized mitochondrial DNA (ox-mtDNA) and mitophagy, thereby activating the NLRP3 inflammasome in SD rat liver. sodium arsenite 14-20 NLR family, pyrin domain containing 3 Rattus norvegicus 122-127 32544768-6 2020 In vitro, we demonstrated that NaAsO2-induced IR depended upon the NLRP3 inflammasome activation. sodium arsenite 31-37 NLR family, pyrin domain containing 3 Rattus norvegicus 67-72 32607937-8 2020 Exposure of Neuro2A cells to low concentrations of the hypoxic stress inducer cobalt chloride, or to sodium arsenite, an oxidative stressor, also increases cellular proSAAS content and reduces its secretion. sodium arsenite 101-116 proprotein convertase subtilisin/kexin type 1 inhibitor Mus musculus 165-172 32519758-7 2020 NaAsO2 exposure was associated with marked increases in renal inflammatory marker (interleukin-1beta and tumor necrosis factor-alpha) and apoptosis indicators including Bax and caspase-3 levels contaminant with a marked decrease in Bcl-2, an anti-apoptotic protein, in the NaAsO2- treated group compared with the control group. sodium arsenite 0-6 interleukin 1 beta Mus musculus 83-100 32519758-7 2020 NaAsO2 exposure was associated with marked increases in renal inflammatory marker (interleukin-1beta and tumor necrosis factor-alpha) and apoptosis indicators including Bax and caspase-3 levels contaminant with a marked decrease in Bcl-2, an anti-apoptotic protein, in the NaAsO2- treated group compared with the control group. sodium arsenite 0-6 tumor necrosis factor Mus musculus 105-132 32519758-7 2020 NaAsO2 exposure was associated with marked increases in renal inflammatory marker (interleukin-1beta and tumor necrosis factor-alpha) and apoptosis indicators including Bax and caspase-3 levels contaminant with a marked decrease in Bcl-2, an anti-apoptotic protein, in the NaAsO2- treated group compared with the control group. sodium arsenite 0-6 BCL2-associated X protein Mus musculus 169-172 32519758-7 2020 NaAsO2 exposure was associated with marked increases in renal inflammatory marker (interleukin-1beta and tumor necrosis factor-alpha) and apoptosis indicators including Bax and caspase-3 levels contaminant with a marked decrease in Bcl-2, an anti-apoptotic protein, in the NaAsO2- treated group compared with the control group. sodium arsenite 0-6 caspase 3 Mus musculus 177-186 32519758-7 2020 NaAsO2 exposure was associated with marked increases in renal inflammatory marker (interleukin-1beta and tumor necrosis factor-alpha) and apoptosis indicators including Bax and caspase-3 levels contaminant with a marked decrease in Bcl-2, an anti-apoptotic protein, in the NaAsO2- treated group compared with the control group. sodium arsenite 0-6 B cell leukemia/lymphoma 2 Mus musculus 232-237 32506763-5 2020 Results showed that death receptor 5 (DR5) was a mediator of NaAsO2 -induced apoptosis by enhancing construction of the death-inducing signaling complex (DISC). sodium arsenite 61-67 TNF receptor superfamily member 10b Homo sapiens 20-36 32506763-5 2020 Results showed that death receptor 5 (DR5) was a mediator of NaAsO2 -induced apoptosis by enhancing construction of the death-inducing signaling complex (DISC). sodium arsenite 61-67 TNF receptor superfamily member 10b Homo sapiens 38-41 32506763-7 2020 Further results showed that NaAsO2 increased expression in biomarker of endoplasmic reticulum (ER) stress and activated the protein kinase R-like ER kinase (PERK)-eukaryotic translation initiation 2alpha (eIF2alpha)-activating transcription factor 4 (ATF4) pathway. sodium arsenite 28-34 eukaryotic translation initiation factor 2A Homo sapiens 205-214 32506763-7 2020 Further results showed that NaAsO2 increased expression in biomarker of endoplasmic reticulum (ER) stress and activated the protein kinase R-like ER kinase (PERK)-eukaryotic translation initiation 2alpha (eIF2alpha)-activating transcription factor 4 (ATF4) pathway. sodium arsenite 28-34 activating transcription factor 4 Homo sapiens 216-249 32506763-7 2020 Further results showed that NaAsO2 increased expression in biomarker of endoplasmic reticulum (ER) stress and activated the protein kinase R-like ER kinase (PERK)-eukaryotic translation initiation 2alpha (eIF2alpha)-activating transcription factor 4 (ATF4) pathway. sodium arsenite 28-34 activating transcription factor 4 Homo sapiens 251-255 32506763-8 2020 PERK inhibitor and ATF4 siRNA significantly attenuated NaAsO2 -induced CHOP and DR5 expressions. sodium arsenite 55-61 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 0-4 32506763-8 2020 PERK inhibitor and ATF4 siRNA significantly attenuated NaAsO2 -induced CHOP and DR5 expressions. sodium arsenite 55-61 activating transcription factor 4 Homo sapiens 19-23 32506763-8 2020 PERK inhibitor and ATF4 siRNA significantly attenuated NaAsO2 -induced CHOP and DR5 expressions. sodium arsenite 55-61 DNA damage inducible transcript 3 Homo sapiens 71-75 32506763-8 2020 PERK inhibitor and ATF4 siRNA significantly attenuated NaAsO2 -induced CHOP and DR5 expressions. sodium arsenite 55-61 TNF receptor superfamily member 10b Homo sapiens 80-83 32506763-10 2020 Taken together, the results indicate that ROS-mediated PERK-eIF2alpha-ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP-DR5 signaling in L-02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic-induced hepatotoxicity. sodium arsenite 96-102 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 55-59 32506763-10 2020 Taken together, the results indicate that ROS-mediated PERK-eIF2alpha-ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP-DR5 signaling in L-02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic-induced hepatotoxicity. sodium arsenite 96-102 eukaryotic translation initiation factor 2A Homo sapiens 60-69 32506763-10 2020 Taken together, the results indicate that ROS-mediated PERK-eIF2alpha-ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP-DR5 signaling in L-02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic-induced hepatotoxicity. sodium arsenite 96-102 activating transcription factor 4 Homo sapiens 70-74 32506763-10 2020 Taken together, the results indicate that ROS-mediated PERK-eIF2alpha-ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP-DR5 signaling in L-02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic-induced hepatotoxicity. sodium arsenite 96-102 DNA damage inducible transcript 3 Homo sapiens 184-188 32506763-10 2020 Taken together, the results indicate that ROS-mediated PERK-eIF2alpha-ATF4 pathway activated by NaAsO2 is the critical upstream event for subsequent apoptosis induction via regulating CHOP-DR5 signaling in L-02 cells when chronic exposure to arsenic, and support that antioxidants might be potential therapeutic agents for preventing or delaying the onset and progress of arsenic-induced hepatotoxicity. sodium arsenite 96-102 TNF receptor superfamily member 10b Homo sapiens 189-192 32531573-5 2020 Our results showed that sodium arsenite treatment significantly reduced insulin secretion in pancreatic islets. sodium arsenite 24-39 pancreatic and duodenal homeobox 1 Rattus norvegicus 93-103 32531573-6 2020 It was revealed that the methylation of glucose transporter 2 (Glut2) gene was changed at two cytosine-phosphate-guanine (CpG) sites (-1743, -1734) in the promoter region of the sodium arsenite-treated group comparing to the control. sodium arsenite 178-193 solute carrier family 2 member 2 Rattus norvegicus 40-61 32531573-6 2020 It was revealed that the methylation of glucose transporter 2 (Glut2) gene was changed at two cytosine-phosphate-guanine (CpG) sites (-1743, -1734) in the promoter region of the sodium arsenite-treated group comparing to the control. sodium arsenite 178-193 solute carrier family 2 member 2 Rattus norvegicus 63-68 32531573-8 2020 Measuring the gene expression level showed increase in Glut2 expression, while the expression of insulin (INS) and Pdx1 were significantly affected by sodium arsenite treatment. sodium arsenite 151-166 pancreatic and duodenal homeobox 1 Rattus norvegicus 115-119 32531573-9 2020 This study revealed that exposure to sodium arsenite changed the DNA methylation pattern of Glut2, a key transporter of glucose entry into the pancreatic beta cells (beta-cells). sodium arsenite 37-52 solute carrier family 2 member 2 Rattus norvegicus 92-97 32531573-9 2020 This study revealed that exposure to sodium arsenite changed the DNA methylation pattern of Glut2, a key transporter of glucose entry into the pancreatic beta cells (beta-cells). sodium arsenite 37-52 pancreatic and duodenal homeobox 1 Rattus norvegicus 143-153 32531574-9 2020 In 1.5 mM NaAsO2 group, the decrease of igfbp3 and igfbp5b was almost obvious, about 78.2% and 72.2%. sodium arsenite 10-16 insulin-like growth factor binding protein 3 Danio rerio 40-46 32531574-9 2020 In 1.5 mM NaAsO2 group, the decrease of igfbp3 and igfbp5b was almost obvious, about 78.2% and 72.2%. sodium arsenite 10-16 insulin-like growth factor binding protein 5b Danio rerio 51-58 33241020-11 2020 Furthermore, knockdown of GRP78 to alleviate ER stress, or overexpression of SERCA2 to restore intracellular calcium homeostasis can inhibit the NaAsO2 effect. sodium arsenite 145-151 heat shock protein family A (Hsp70) member 5 Homo sapiens 26-31 33241020-9 2020 Furthermore, after knocking down GRP78 [endoplasmic reticulum (ER) chaperone BiP] or overexpressing of SERCA2 (ATPase sarcoplasmic/ER Ca2+ transporting 2) in NaAsO2-induced LX2 cells, we detected the changes in ER stress and calcium homeostasis in LX2 cells. sodium arsenite 158-164 heat shock protein family A (Hsp70) member 5 Homo sapiens 33-38 33241020-9 2020 Furthermore, after knocking down GRP78 [endoplasmic reticulum (ER) chaperone BiP] or overexpressing of SERCA2 (ATPase sarcoplasmic/ER Ca2+ transporting 2) in NaAsO2-induced LX2 cells, we detected the changes in ER stress and calcium homeostasis in LX2 cells. sodium arsenite 158-164 heat shock protein family A (Hsp70) member 5 Homo sapiens 77-80 33241020-9 2020 Furthermore, after knocking down GRP78 [endoplasmic reticulum (ER) chaperone BiP] or overexpressing of SERCA2 (ATPase sarcoplasmic/ER Ca2+ transporting 2) in NaAsO2-induced LX2 cells, we detected the changes in ER stress and calcium homeostasis in LX2 cells. sodium arsenite 158-164 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Homo sapiens 103-109 33241020-10 2020 Results: NaAsO2 exposure promoted apoptosis, increased ECM secretion, produced ER stress, and disrupted calcium homeostasis, which could be attenuated by oxymatrine treatment. sodium arsenite 9-15 multimerin 1 Homo sapiens 55-58 33241020-11 2020 Furthermore, knockdown of GRP78 to alleviate ER stress, or overexpression of SERCA2 to restore intracellular calcium homeostasis can inhibit the NaAsO2 effect. sodium arsenite 145-151 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Homo sapiens 77-83 33241020-12 2020 Conclusions: Oxymatrine treatment could improve calcium homeostasis and attenuate ER stress to reverse NaAsO2-induced HSC activation and ECM secretion, which are the significant phenotypes of HF. sodium arsenite 103-109 fucosyltransferase 1 (H blood group) Homo sapiens 118-121 32905139-4 2020 In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes. sodium arsenite 84-90 DNA methyltransferase 1 Homo sapiens 155-160 32905139-4 2020 In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes. sodium arsenite 84-90 forkhead box P3 Homo sapiens 165-170 32905139-4 2020 In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes. sodium arsenite 84-90 forkhead box P3 Homo sapiens 248-253 32905139-4 2020 In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes. sodium arsenite 84-90 interleukin 10 Homo sapiens 342-356 32905139-4 2020 In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes. sodium arsenite 84-90 interleukin 10 Homo sapiens 358-363 32905139-4 2020 In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes. sodium arsenite 84-90 interleukin 10 Homo sapiens 369-383 32905139-4 2020 In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes. sodium arsenite 84-90 CD4 molecule Homo sapiens 421-424 32905139-4 2020 In this study, after primary human lymphocytes were treated with different doses of NaAsO2, our results showed that arsenic induced the high expression of DNMT1 and Foxp3 gene promoter methylation level, thereby inhibiting the expression levels of Foxp3, followed by decreasing Tregs and reducing related anti-inflammatory cytokines, such as interleukin 10 (IL-10) and interleukin 10 (IL-35), and increasing the ratio of CD4+/CD8+ T cells in lymphocytes. sodium arsenite 84-90 CD8a molecule Homo sapiens 426-429 32474354-7 2020 RESULTS: The data showed that sodium arsenite and DMA exposure significantly increased the tissue arsenic contents, ROS, TBARS levels, catalase, SOD activities and significantly decreased GSH level which might be responsible for an increased 8-OHdG level. sodium arsenite 30-45 catalase Rattus norvegicus 135-143 32278034-0 2020 PINK1/Parkin-mediated mitophagy is involved in NaAsO2-induced apoptosis of human hepatic cells through activation of ERK signaling. sodium arsenite 47-53 PTEN induced kinase 1 Homo sapiens 0-5 32278034-0 2020 PINK1/Parkin-mediated mitophagy is involved in NaAsO2-induced apoptosis of human hepatic cells through activation of ERK signaling. sodium arsenite 47-53 mitogen-activated protein kinase 1 Homo sapiens 117-120 32278034-2 2020 Here we examined NaAsO2-induced mitochondrial damage in the L-02 cell led to mitochondrial depolarization and cytochrome c release, mitophagy, apoptosis in a dose response manner. sodium arsenite 17-23 cytochrome c, somatic Homo sapiens 110-122 32278034-8 2020 When the ERK signaling inhibitor PD98095 was used, there was a similar result that mitophagy was reduced though in contrast with CsA the apoptosis rate was also decreased compared with NaAsO2 alone. sodium arsenite 185-191 mitogen-activated protein kinase 1 Homo sapiens 9-12 32278034-9 2020 This result, along with the increased levels of ERK measured here in response to NaAsO2, indicates that ERK activation is a second key molecular response to NaAsO2 through the activation of both apoptosis and mitophagy. sodium arsenite 81-87 mitogen-activated protein kinase 1 Homo sapiens 48-51 32278034-9 2020 This result, along with the increased levels of ERK measured here in response to NaAsO2, indicates that ERK activation is a second key molecular response to NaAsO2 through the activation of both apoptosis and mitophagy. sodium arsenite 81-87 mitogen-activated protein kinase 1 Homo sapiens 104-107 32278034-9 2020 This result, along with the increased levels of ERK measured here in response to NaAsO2, indicates that ERK activation is a second key molecular response to NaAsO2 through the activation of both apoptosis and mitophagy. sodium arsenite 157-163 mitogen-activated protein kinase 1 Homo sapiens 48-51 32278034-9 2020 This result, along with the increased levels of ERK measured here in response to NaAsO2, indicates that ERK activation is a second key molecular response to NaAsO2 through the activation of both apoptosis and mitophagy. sodium arsenite 157-163 mitogen-activated protein kinase 1 Homo sapiens 104-107 32278034-10 2020 Thus the results with CsA indicate that the likely key biological event in NaAsO2 toxicity is at the level of the mitochondria leading to cytochrome c release and apoptosis. sodium arsenite 75-81 cytochrome c, somatic Homo sapiens 138-150 32278034-11 2020 Mitophagy is increased in response to a secondary effect of NaAsO2 on ERK signaling that activates both mitophagy and apoptosis. sodium arsenite 60-66 mitogen-activated protein kinase 1 Homo sapiens 70-73 32278034-13 2020 When ERK signaling is inhibited by PD98095 both the levels of apoptosis and mitophagy are decreased compared with the response produced by NaAsO2 alone in comparison to the inhibition of mitophagy by CsA that reduced mitophagy but dramatically increased apoptosis in response. sodium arsenite 139-145 mitogen-activated protein kinase 1 Homo sapiens 5-8 32760496-7 2020 Splenic NF-kappaB, MAPK and NRF2 protein levels by treatment of 25 mg/L NaAsO2 for 1, 3 and 12 months and 25 mg/L and 50 mg/L NaAsO2 for 12 months were assessed by western blot. sodium arsenite 72-78 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 8-17 32696740-0 2020 [Injury of L-02 hepatocytes induced by NaAsO2 is related to down-regulated expression of p14ARF and increased expression of MDM2 and p53]. sodium arsenite 39-45 transformed mouse 3T3 cell double minute 2 Mus musculus 124-128 32696740-0 2020 [Injury of L-02 hepatocytes induced by NaAsO2 is related to down-regulated expression of p14ARF and increased expression of MDM2 and p53]. sodium arsenite 39-45 transformation related protein 53, pseudogene Mus musculus 133-136 32696740-1 2020 Objective To investigate the effects of sodium arsenite (NaAsO2) on p14 alternative reading frame (p14ARF), murine double minute 2 (MDM2) and p53 expressions in L-02 hepatocytes. sodium arsenite 40-55 S100 calcium binding protein A9 (calgranulin B) Mus musculus 68-71 32696740-1 2020 Objective To investigate the effects of sodium arsenite (NaAsO2) on p14 alternative reading frame (p14ARF), murine double minute 2 (MDM2) and p53 expressions in L-02 hepatocytes. sodium arsenite 57-63 S100 calcium binding protein A9 (calgranulin B) Mus musculus 68-71 32696740-9 2020 Conclusion The injury of L-02 hepatocytes induced by NaAsO2 may be related to the down-regulation of p14ARF expression and the up-regulation of p53 and MDM2 expression. sodium arsenite 53-59 transformation related protein 53, pseudogene Mus musculus 144-147 32696740-9 2020 Conclusion The injury of L-02 hepatocytes induced by NaAsO2 may be related to the down-regulation of p14ARF expression and the up-regulation of p53 and MDM2 expression. sodium arsenite 53-59 transformed mouse 3T3 cell double minute 2 Mus musculus 152-156 32197950-3 2020 Herein, was studied the role of aromatase activation and the GPER1 pathway on sodium arsenite-induced promotion and progression of MDA-MB-231 and MDA-MB-453 BCa cell lines. sodium arsenite 78-93 G protein-coupled estrogen receptor 1 Homo sapiens 61-66 32197950-5 2020 Using letrozole (an aromatase inhibitor) and G-15 (a GPER1-selective antagonist), we demonstrated that sodium arsenite-induced proliferation and migration is mediated by induction of aromatase enzyme and, at least in part, by GPER1 activation in MDA-MB-231 and MDA-MB-453 cells. sodium arsenite 103-118 G protein-coupled estrogen receptor 1 Homo sapiens 53-58 32197950-5 2020 Using letrozole (an aromatase inhibitor) and G-15 (a GPER1-selective antagonist), we demonstrated that sodium arsenite-induced proliferation and migration is mediated by induction of aromatase enzyme and, at least in part, by GPER1 activation in MDA-MB-231 and MDA-MB-453 cells. sodium arsenite 103-118 G protein-coupled estrogen receptor 1 Homo sapiens 226-231 32197950-6 2020 Sodium arsenite induced phosphorylation of Src that participated in sodium arsenite-induced aromatase activity, and -cell proliferation of MDA-MB-231 cell line. sodium arsenite 0-15 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 43-46 32197950-7 2020 Overall, data suggests that sodium arsenite induces a positive-feedback loop, resulting in the promotion and progression of BCa cells, through induction of aromatase activity, E2 production, GPER1 stimulation, and Src activation. sodium arsenite 28-43 G protein-coupled estrogen receptor 1 Homo sapiens 191-196 32197950-7 2020 Overall, data suggests that sodium arsenite induces a positive-feedback loop, resulting in the promotion and progression of BCa cells, through induction of aromatase activity, E2 production, GPER1 stimulation, and Src activation. sodium arsenite 28-43 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 214-217 32301004-0 2020 The role of PSMB5 in sodium arsenite-induced oxidative stress in L-02 cells. sodium arsenite 21-36 proteasome 20S subunit beta 5 Homo sapiens 12-17 32301004-4 2020 This paper aims to study the role and mechanism of PSMB5 in sodium arsenite (NaAsO2)-induced oxidative stress liver injury in L-02 cells. sodium arsenite 60-75 proteasome 20S subunit beta 5 Homo sapiens 51-56 32301004-4 2020 This paper aims to study the role and mechanism of PSMB5 in sodium arsenite (NaAsO2)-induced oxidative stress liver injury in L-02 cells. sodium arsenite 77-83 proteasome 20S subunit beta 5 Homo sapiens 51-56 32301004-7 2020 The results demonstrated that NaAsO2 could induce oxidative stress-induced liver injury and the activity of 20S proteasome and the protein expression of PSMB5, SOD1, and GPx1 decreased. sodium arsenite 30-36 proteasome 20S subunit beta 5 Homo sapiens 153-158 32301004-7 2020 The results demonstrated that NaAsO2 could induce oxidative stress-induced liver injury and the activity of 20S proteasome and the protein expression of PSMB5, SOD1, and GPx1 decreased. sodium arsenite 30-36 superoxide dismutase 1 Homo sapiens 160-164 32301004-7 2020 The results demonstrated that NaAsO2 could induce oxidative stress-induced liver injury and the activity of 20S proteasome and the protein expression of PSMB5, SOD1, and GPx1 decreased. sodium arsenite 30-36 glutathione peroxidase 1 Homo sapiens 170-174 32301004-9 2020 After MG132 or PSMB5-siRNA pretreatment, and then L-02 cells were treated with NaAsO2, the gene expression of PSMB remarkably decreased; however, the protein expression of SOD1 and GPx1 increased. sodium arsenite 79-85 proteasome 20S subunit beta 5 Homo sapiens 15-20 32301004-9 2020 After MG132 or PSMB5-siRNA pretreatment, and then L-02 cells were treated with NaAsO2, the gene expression of PSMB remarkably decreased; however, the protein expression of SOD1 and GPx1 increased. sodium arsenite 79-85 superoxide dismutase 1 Homo sapiens 172-176 32301004-9 2020 After MG132 or PSMB5-siRNA pretreatment, and then L-02 cells were treated with NaAsO2, the gene expression of PSMB remarkably decreased; however, the protein expression of SOD1 and GPx1 increased. sodium arsenite 79-85 glutathione peroxidase 1 Homo sapiens 181-185 32301004-10 2020 Overall, NaAsO2 exposure could induce oxidative stress liver injury and low expression of PSMB5 in L-02 cells, and PSMB5 might play an important role in the regulation of oxidative stress by regulating the expression of SOD1 and Gpx1. sodium arsenite 9-15 proteasome 20S subunit beta 5 Homo sapiens 90-95 32301004-10 2020 Overall, NaAsO2 exposure could induce oxidative stress liver injury and low expression of PSMB5 in L-02 cells, and PSMB5 might play an important role in the regulation of oxidative stress by regulating the expression of SOD1 and Gpx1. sodium arsenite 9-15 superoxide dismutase 1 Homo sapiens 220-224 32301004-10 2020 Overall, NaAsO2 exposure could induce oxidative stress liver injury and low expression of PSMB5 in L-02 cells, and PSMB5 might play an important role in the regulation of oxidative stress by regulating the expression of SOD1 and Gpx1. sodium arsenite 9-15 glutathione peroxidase 1 Homo sapiens 229-233 32201329-6 2020 In this study, we found that low-dose sodium arsenite (As (III)) repressed major airway mucins-MUC5AC and MUC5B at both mRNA and protein levels. sodium arsenite 38-53 mucin 5AC, oligomeric mucus/gel-forming Homo sapiens 95-101 32201329-6 2020 In this study, we found that low-dose sodium arsenite (As (III)) repressed major airway mucins-MUC5AC and MUC5B at both mRNA and protein levels. sodium arsenite 38-53 mucin 5B, oligomeric mucus/gel-forming Homo sapiens 106-111 31587475-6 2020 SA similarly increased inflammatory reactions by increasing the level of interleukin-6, tumor necrosis factor-alpha, and interleukin-1beta. sodium arsenite 0-2 interleukin 6 Homo sapiens 73-115 31587475-6 2020 SA similarly increased inflammatory reactions by increasing the level of interleukin-6, tumor necrosis factor-alpha, and interleukin-1beta. sodium arsenite 0-2 interleukin 1 beta Homo sapiens 121-138 31587475-7 2020 In addition, SA provoked the apoptosis by expanding the p53 and Bax levels, terminal deoxynucleotidyl transferase dUTP nick end labeling, and expression of caspase-3. sodium arsenite 13-15 tumor protein p53 Homo sapiens 56-59 31587475-7 2020 In addition, SA provoked the apoptosis by expanding the p53 and Bax levels, terminal deoxynucleotidyl transferase dUTP nick end labeling, and expression of caspase-3. sodium arsenite 13-15 BCL2 associated X, apoptosis regulator Homo sapiens 64-67 31587475-7 2020 In addition, SA provoked the apoptosis by expanding the p53 and Bax levels, terminal deoxynucleotidyl transferase dUTP nick end labeling, and expression of caspase-3. sodium arsenite 13-15 caspase 3 Homo sapiens 156-165 32001831-8 2020 Furthermore, prolonged nicotine exposure interferes with p53 function triggered by sodium arsenite. sodium arsenite 83-98 tumor protein p53 Homo sapiens 57-60 31669990-4 2020 In addition, NaAsO2 upregulated autophagy flux, elevated the level of cytoplasmic cathepsin B (CTSB), and activated the NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome in a subtle way. sodium arsenite 13-19 cathepsin B Rattus norvegicus 82-93 31669990-4 2020 In addition, NaAsO2 upregulated autophagy flux, elevated the level of cytoplasmic cathepsin B (CTSB), and activated the NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome in a subtle way. sodium arsenite 13-19 cathepsin B Rattus norvegicus 95-99 31669990-4 2020 In addition, NaAsO2 upregulated autophagy flux, elevated the level of cytoplasmic cathepsin B (CTSB), and activated the NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome in a subtle way. sodium arsenite 13-19 NLR family, pyrin domain containing 3 Rattus norvegicus 120-164 31669990-4 2020 In addition, NaAsO2 upregulated autophagy flux, elevated the level of cytoplasmic cathepsin B (CTSB), and activated the NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasome in a subtle way. sodium arsenite 13-19 NLR family, pyrin domain containing 3 Rattus norvegicus 166-171 31669990-5 2020 Consistent with these findings in vivo, we demonstrated that NaAsO2-induced activation of HSCs depended on CTSB-mediated NLRP3 inflammasome activation in HSC-t6 cells and rats primary HSCs. sodium arsenite 61-67 cathepsin B Rattus norvegicus 107-111 31669990-5 2020 Consistent with these findings in vivo, we demonstrated that NaAsO2-induced activation of HSCs depended on CTSB-mediated NLRP3 inflammasome activation in HSC-t6 cells and rats primary HSCs. sodium arsenite 61-67 NLR family, pyrin domain containing 3 Rattus norvegicus 121-126 31669990-7 2020 In summary, these results indicated that NaAsO2 induced HSCs activation via autophagic-CTSB-NLRP3 inflammasome pathway. sodium arsenite 41-47 cathepsin B Rattus norvegicus 87-91 31669990-7 2020 In summary, these results indicated that NaAsO2 induced HSCs activation via autophagic-CTSB-NLRP3 inflammasome pathway. sodium arsenite 41-47 NLR family, pyrin domain containing 3 Rattus norvegicus 92-97 31766100-6 2020 It alleviated sodium arsenite [As(III)]-induced intracellular oxidative stress in an Nrf2-dependent manner. sodium arsenite 14-29 NFE2 like bZIP transcription factor 2 Homo sapiens 85-89 31771591-9 2019 Knockout of SPOP or expression of prostate cancer-associated SPOP mutants conferred resistance to death caused by SG inducers (e.g. docetaxel, sodium arsenite and H2O2) in prostate cancer cells. sodium arsenite 143-158 speckle type BTB/POZ protein Homo sapiens 12-16 31771591-9 2019 Knockout of SPOP or expression of prostate cancer-associated SPOP mutants conferred resistance to death caused by SG inducers (e.g. docetaxel, sodium arsenite and H2O2) in prostate cancer cells. sodium arsenite 143-158 speckle type BTB/POZ protein Homo sapiens 61-65 31272005-5 2019 We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation. sodium arsenite 30-45 latexin Homo sapiens 64-67 31272005-5 2019 We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation. sodium arsenite 30-45 latexin Homo sapiens 112-115 31272005-5 2019 We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation. sodium arsenite 30-45 latexin Homo sapiens 112-115 31272005-5 2019 We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation. sodium arsenite 30-45 latexin Homo sapiens 112-115 31272005-5 2019 We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation. sodium arsenite 30-45 latexin Homo sapiens 112-115 31272005-5 2019 We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation. sodium arsenite 30-45 latexin Homo sapiens 112-115 31272005-5 2019 We determined IC50 values for sodium arsenite-dependent (0.1-10 muM) inhibition of hNPC and rNPC migration (6.0 muM; >10 muM), neuronal (2.7 muM; 4.4 muM) and oligodendrocyte (1.1 muM; 2.0 muM) differentiation. sodium arsenite 30-45 latexin Homo sapiens 112-115 31029697-6 2019 The carcinogenic chemical stressor sodium arsenite caused the induction of HIPK2-dependent cell death and also resulted in a rapid and complete nuclear translocation of HIPK2, showing that the intracellular distribution of this kinase can undergo dynamic regulation. sodium arsenite 35-50 homeodomain interacting protein kinase 2 Homo sapiens 75-80 31029697-6 2019 The carcinogenic chemical stressor sodium arsenite caused the induction of HIPK2-dependent cell death and also resulted in a rapid and complete nuclear translocation of HIPK2, showing that the intracellular distribution of this kinase can undergo dynamic regulation. sodium arsenite 35-50 homeodomain interacting protein kinase 2 Homo sapiens 169-174 31322264-10 2019 The data indicated that WIF1 gene expression was decreased by sodium arsenite, whereas this was not noted for CBS, MALAT1 and ADORA1. sodium arsenite 62-77 WNT inhibitory factor 1 Homo sapiens 24-28 31322264-11 2019 Sodium arsenite decreased mRNA and protein expression levels of the WIF1 gene. sodium arsenite 0-15 WNT inhibitory factor 1 Homo sapiens 68-72 31322264-15 2019 In summary, the data indicated that sodium arsenite decreased WIF1 gene expression and promoted cell migration. sodium arsenite 36-51 WNT inhibitory factor 1 Homo sapiens 62-66 31146095-4 2019 Global m6A methylation levelsweremeasured in total RNA after exposuretotwo carcinogens (PM and sodium arsenite) for 24- and 48-h, and totwo endocrine disruptors (bisphenol A and vinclozolin)for 24-h.Global m6A methylation level significantly decreased with exposure to >62 mug/mlPM, >1 muM sodium arsenite, >1 muM bisphenol A (BPA), and0.1 muM vinclozolin. sodium arsenite 95-110 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Homo sapiens 7-10 31146095-4 2019 Global m6A methylation levelsweremeasured in total RNA after exposuretotwo carcinogens (PM and sodium arsenite) for 24- and 48-h, and totwo endocrine disruptors (bisphenol A and vinclozolin)for 24-h.Global m6A methylation level significantly decreased with exposure to >62 mug/mlPM, >1 muM sodium arsenite, >1 muM bisphenol A (BPA), and0.1 muM vinclozolin. sodium arsenite 296-311 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit Homo sapiens 7-10 31140275-6 2019 By employing a multiple-reaction monitoring (MRM)-based targeted proteomic method, we found that the protein level of RhoB was substantially decreased in IMR90 human lung fibroblast cells upon a 12-h exposure to 5 muM NaAsO2. sodium arsenite 218-224 ras homolog family member B Homo sapiens 118-122 31216693-6 2019 SA activates the heme-regulated eIF2alpha (HRI) kinase, which phosphorylates eukaryotic translation initiation factor 2 alpha (eIF2alpha) to induce stress granule (SG) formation. sodium arsenite 0-2 eukaryotic translation initiation factor 2A Homo sapiens 77-125 31216693-6 2019 SA activates the heme-regulated eIF2alpha (HRI) kinase, which phosphorylates eukaryotic translation initiation factor 2 alpha (eIF2alpha) to induce stress granule (SG) formation. sodium arsenite 0-2 eukaryotic translation initiation factor 2A Homo sapiens 32-41 30898623-2 2019 Our present study found that during H2O2 or NaAsO2 induced injury of VSMC, the expression of miR-155-5p significantly increased. sodium arsenite 44-50 microRNA 155 Homo sapiens 93-100 30898623-3 2019 While silencing of miR-155-5p can attenuate H2O2 or NaAsO2 suppressed viability and induced apoptosis of VSMCs. sodium arsenite 52-58 microRNA 155 Homo sapiens 19-26 31199764-6 2019 Results Our evaluation revealed that 8 days of sodium arsenite (10 mg/kg body weight) treatment reduced the activities of the uterine enzymatic antioxidants superoxide dismutase, catalase, and peroxidase. sodium arsenite 47-62 catalase Rattus norvegicus 179-187 31075539-0 2019 DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress. sodium arsenite 46-61 DISC1 scaffold protein Homo sapiens 0-5 31075539-6 2019 DISC1 knockdown enhanced inhibition of protein synthesis in cells treated with sodium arsenite (SA), an oxidative agent used for studying stress granules (SGs) dynamics and translational control. sodium arsenite 79-94 DISC1 scaffold protein Homo sapiens 0-5 31075539-6 2019 DISC1 knockdown enhanced inhibition of protein synthesis in cells treated with sodium arsenite (SA), an oxidative agent used for studying stress granules (SGs) dynamics and translational control. sodium arsenite 96-98 DISC1 scaffold protein Homo sapiens 0-5 31075539-8 2019 DISC1 decreased SGs number in SA-treated cells, but resided outside SGs and maintained protein synthesis independently of a proper SG nucleation. sodium arsenite 30-32 DISC1 scaffold protein Homo sapiens 0-5 31075539-9 2019 DISC1-dependent stimulation of translation in SA-treated cells was supported by its interaction with eIF3h, a component of the canonical translation initiation machinery. sodium arsenite 46-48 DISC1 scaffold protein Homo sapiens 0-5 31075539-9 2019 DISC1-dependent stimulation of translation in SA-treated cells was supported by its interaction with eIF3h, a component of the canonical translation initiation machinery. sodium arsenite 46-48 eukaryotic translation initiation factor 3 subunit H Homo sapiens 101-106 31075539-10 2019 Consistent with a role in the homeostatic maintenance of translation, DISC1 knockdown or overexpression decreased cell viability after SA exposure. sodium arsenite 135-137 DISC1 scaffold protein Homo sapiens 70-75 31139082-6 2019 Moreover, Pts treatment further dramatically inhibited NaAsO2-induced apoptosis, specifically the mitochondrial mediation of apoptosis, which coincided with the effective recovery of NaAsO2-induced mitochondrial membrane potential (DeltaPsim) depolarization and cytochrome c release from the mitochondria. sodium arsenite 55-61 cytochrome c, somatic Homo sapiens 262-274 31139082-6 2019 Moreover, Pts treatment further dramatically inhibited NaAsO2-induced apoptosis, specifically the mitochondrial mediation of apoptosis, which coincided with the effective recovery of NaAsO2-induced mitochondrial membrane potential (DeltaPsim) depolarization and cytochrome c release from the mitochondria. sodium arsenite 183-189 cytochrome c, somatic Homo sapiens 262-274 31139082-9 2019 In addition, the effects of Pts on NaAsO2-induced cell viability were largely weakened when Nrf2 was knocked down. sodium arsenite 35-41 NFE2 like bZIP transcription factor 2 Homo sapiens 92-96 31050222-3 2019 Specifically, oxidative stress induced in a human recombinant TDP-43- or FUS-tGFP U2OS cell line by exposure to sodium arsenite was shown to be significantly reduced by our collection of molecules using in vitro imaging of FUS and TDP-43 stress granules. sodium arsenite 112-127 TAR DNA binding protein Homo sapiens 62-68 31050222-3 2019 Specifically, oxidative stress induced in a human recombinant TDP-43- or FUS-tGFP U2OS cell line by exposure to sodium arsenite was shown to be significantly reduced by our collection of molecules using in vitro imaging of FUS and TDP-43 stress granules. sodium arsenite 112-127 FUS RNA binding protein Homo sapiens 73-76 31050222-3 2019 Specifically, oxidative stress induced in a human recombinant TDP-43- or FUS-tGFP U2OS cell line by exposure to sodium arsenite was shown to be significantly reduced by our collection of molecules using in vitro imaging of FUS and TDP-43 stress granules. sodium arsenite 112-127 FUS RNA binding protein Homo sapiens 223-226 31050222-3 2019 Specifically, oxidative stress induced in a human recombinant TDP-43- or FUS-tGFP U2OS cell line by exposure to sodium arsenite was shown to be significantly reduced by our collection of molecules using in vitro imaging of FUS and TDP-43 stress granules. sodium arsenite 112-127 TAR DNA binding protein Homo sapiens 231-237 31065237-3 2019 Further, we have investigated the effect of NaAsO2 on the androgen receptor. sodium arsenite 44-50 androgen receptor Homo sapiens 58-75 30721701-9 2019 Activation of p38MAPK, by Sodium Arsenite or Anisomycin, mimicked the inhibitory effect of Sildenafil on the exchanger. sodium arsenite 26-41 mitogen activated protein kinase 14 Rattus norvegicus 14-21 30773942-5 2019 Moreover, NOR protected human lung epithelial Beas-2B cells against sodium arsenite [As(III)]-induced cytotoxicity in an Nrf2-dependent manner. sodium arsenite 68-83 NFE2 like bZIP transcription factor 2 Homo sapiens 121-125 30664189-4 2019 In this study, we examined the effects of sodium arsenite (NaAsIII) exposure in ERalpha-positive breast cancer cells in vitro and in mammary tumor xenografts. sodium arsenite 42-57 estrogen receptor 1 Homo sapiens 80-87 30796345-3 2019 We found that similarly to canonical Hsps, Arc/Arg3.1 is also markedly induced by heat shock and by other cellular stress inducers, including diamide, sodium arsenite and H2O2 in various cells. sodium arsenite 151-166 activity regulated cytoskeleton associated protein Homo sapiens 43-53 31353640-1 2019 In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats. sodium arsenite 59-74 aldo-keto reductase family 1 member B1 Rattus norvegicus 201-203 31353640-1 2019 In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats. sodium arsenite 59-74 paraoxonase 1 Rattus norvegicus 221-225 31353640-1 2019 In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats. sodium arsenite 59-74 butyrylcholinesterase Rattus norvegicus 259-282 31353640-1 2019 In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats. sodium arsenite 59-74 butyrylcholinesterase Rattus norvegicus 284-288 31353640-1 2019 In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats. sodium arsenite 76-78 paraoxonase 1 Rattus norvegicus 206-219 31353640-1 2019 In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats. sodium arsenite 76-78 paraoxonase 1 Rattus norvegicus 221-225 31353640-1 2019 In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats. sodium arsenite 76-78 butyrylcholinesterase Rattus norvegicus 259-282 31353640-1 2019 In our work, it was purposed to investigate the effects of sodium arsenite (SA) and hesperidin (HSP) administered to rats on some metabolic enzymes including carbonic anhydrase (CA), aldose reductase (AR), paraoxonase-1 (PON1), alpha-glycosidase (alpha-Gly), butyrylcholine esterase (BChE), acetylcholine esterase (AChE) enzymes activities in the brain, heart, liver, testis, and kidney tissues of rats. sodium arsenite 76-78 butyrylcholinesterase Rattus norvegicus 284-288 31353640-6 2019 PON1 enzyme activity was increased significantly in kidney and liver tissues of rats HSP groups and decreased SA groups compared to control. sodium arsenite 110-112 paraoxonase 1 Rattus norvegicus 0-4 30408888-9 2019 To study the underlying mechanism of arsenic-induced apoptosis, we exposed PEDF-transfected PC12 cells to NaAsO2. sodium arsenite 106-112 serpin family F member 1 Rattus norvegicus 75-79 30408888-10 2019 We discovered that NaAsO2--induced mitochondrial apoptosis was enhanced in cells that over expressed PEDF. sodium arsenite 19-25 serpin family F member 1 Rattus norvegicus 101-105 31553994-4 2019 SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species. sodium arsenite 0-2 fibronectin 1 Mus musculus 66-77 31553994-4 2019 SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species. sodium arsenite 0-2 fibronectin 1 Mus musculus 79-81 31553994-4 2019 SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species. sodium arsenite 0-2 transforming growth factor, beta 1 Mus musculus 97-105 31553994-4 2019 SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species. sodium arsenite 0-2 transforming growth factor, beta 1 Mus musculus 142-150 31553994-4 2019 SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species. sodium arsenite 0-2 NADPH oxidase 4 Mus musculus 176-191 31553994-4 2019 SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species. sodium arsenite 125-127 transforming growth factor, beta 1 Mus musculus 142-150 31553994-4 2019 SA treatment significantly inhibits alpha-smooth muscle actin and fibronectin (FN) expression in TGF-beta treated NHLFs; and SA also inhibits TGF-beta stimulated expression of NADPH oxidase 4 and accumulation of intracellular reactive oxygen species. sodium arsenite 125-127 NADPH oxidase 4 Mus musculus 176-191 31553994-5 2019 TGF-beta-induced the phosphorylation of ERK and Smad3 were also blocked by SA. sodium arsenite 75-77 transforming growth factor, beta 1 Mus musculus 0-8 31553994-5 2019 TGF-beta-induced the phosphorylation of ERK and Smad3 were also blocked by SA. sodium arsenite 75-77 mitogen-activated protein kinase 1 Mus musculus 40-43 31553994-5 2019 TGF-beta-induced the phosphorylation of ERK and Smad3 were also blocked by SA. sodium arsenite 75-77 SMAD family member 3 Mus musculus 48-53 31553994-6 2019 The administration of SA (IP) suppressed BLM-induced lung fibrosis characterized as the inhibition of collagen deposition, TGF-beta accumulation in bronchoalveolar lavage fluid, and the expression of FN and collagen 1a2 in lung tissue. sodium arsenite 22-24 transforming growth factor, beta 1 Mus musculus 123-131 31553994-6 2019 The administration of SA (IP) suppressed BLM-induced lung fibrosis characterized as the inhibition of collagen deposition, TGF-beta accumulation in bronchoalveolar lavage fluid, and the expression of FN and collagen 1a2 in lung tissue. sodium arsenite 22-24 fibronectin 1 Mus musculus 200-202 31553994-7 2019 This study revealed that SA inhibits TGF-beta-induced lung fibroblast differentiation and BLM-induced pulmonary fibrosis in mice, suggesting that SA could be a potential therapeutic approach to IPF. sodium arsenite 25-27 transforming growth factor, beta 1 Mus musculus 37-45 31553994-7 2019 This study revealed that SA inhibits TGF-beta-induced lung fibroblast differentiation and BLM-induced pulmonary fibrosis in mice, suggesting that SA could be a potential therapeutic approach to IPF. sodium arsenite 146-148 transforming growth factor, beta 1 Mus musculus 37-45 30622953-0 2018 Corrigendum #2 to "Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats". sodium arsenite 50-65 vascular endothelial growth factor A Rattus norvegicus 84-88 30622953-0 2018 Corrigendum #2 to "Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats". sodium arsenite 50-65 kinase insert domain receptor Rattus norvegicus 93-99 30278242-0 2018 Metabolism and disposition of arsenic species from controlled dosing with sodium arsenite in adult female CD-1 mice. sodium arsenite 74-89 CD1 antigen complex Mus musculus 106-110 30130555-0 2018 Sodium arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in mouse embryonic fibroblast cells. sodium arsenite 0-15 E1A binding protein p300 Mus musculus 60-64 30227999-6 2018 Further studies indicated that 7-MBA activated Nrf2 signaling pathway and protected human lung epithelial Beas-2B cells against sodium arsenite [As(III)]-induced cytotoxicity in an Nrf2-dependent manner. sodium arsenite 128-143 NFE2 like bZIP transcription factor 2 Homo sapiens 181-185 29864498-7 2018 Sodium arsenite induced Fas and Bax mRNA expression, then MMA and DMA did not induce mRNA expression in MDA-MB-231 and XWLC-05 cells. sodium arsenite 0-15 BCL2 associated X, apoptosis regulator Homo sapiens 32-35 29945972-5 2018 Here, using a range of human and murine cells, we show that TFEB and TFE3 are activated upon induction of acute oxidative stress by sodium arsenite via an mTOR complex 1 (mTORC1)-independent process. sodium arsenite 132-147 transcription factor EB Mus musculus 60-64 29945972-5 2018 Here, using a range of human and murine cells, we show that TFEB and TFE3 are activated upon induction of acute oxidative stress by sodium arsenite via an mTOR complex 1 (mTORC1)-independent process. sodium arsenite 132-147 transcription factor E3 Mus musculus 69-73 29945972-5 2018 Here, using a range of human and murine cells, we show that TFEB and TFE3 are activated upon induction of acute oxidative stress by sodium arsenite via an mTOR complex 1 (mTORC1)-independent process. sodium arsenite 132-147 CREB regulated transcription coactivator 1 Mus musculus 171-177 29945972-7 2018 Depletion of either the catalytic (PPP2CA+B) or regulatory (PPP2R2A/B55alpha) subunits of PP2A, as well as PP2A inactivation with the specific inhibitor okadaic acid, abolished TFEB and TFE3 activation in response to sodium arsenite. sodium arsenite 217-232 protein phosphatase 2 phosphatase activator Homo sapiens 90-94 29383632-9 2018 The results indicate that SA-intoxicated rats display significantly higher levels of plasma cardiac markers (AST, CK-MB, LDH and cTnI) than normal control animals. sodium arsenite 26-28 troponin I3, cardiac type Rattus norvegicus 129-133 29383632-11 2018 Furthermore, SA-treated rats showed significantly lower WBC, RBC, HGB, HCT and PLT and significantly higher MCV and MCH. sodium arsenite 13-15 oleoyl-ACP hydrolase Rattus norvegicus 116-119 29864931-7 2018 Furthermore, SA enhanced levels of malondialdehyde, tumor necrosis factor-alpha, interleukin-1beta and nitric oxide in testes. sodium arsenite 13-15 tumor necrosis factor Rattus norvegicus 52-79 29864931-7 2018 Furthermore, SA enhanced levels of malondialdehyde, tumor necrosis factor-alpha, interleukin-1beta and nitric oxide in testes. sodium arsenite 13-15 interleukin 1 beta Rattus norvegicus 81-98 29630858-0 2018 Antioxidant supplementation upregulates calbindin expression in cerebellar Purkinje cells of rat pups subjected to post natal exposure to sodium arsenite. sodium arsenite 138-153 calbindin 1 Rattus norvegicus 40-49 29630858-4 2018 The present study focused on determining the strategies that would modulate tissue redox status and calcium binding protein (CaBP) (Calbindin D28k-CB) expression affected adversely by sodium arsenite (NaAsO2) exposure (postnatal) of rat pups. sodium arsenite 184-199 hippocalcin Rattus norvegicus 100-123 29630858-4 2018 The present study focused on determining the strategies that would modulate tissue redox status and calcium binding protein (CaBP) (Calbindin D28k-CB) expression affected adversely by sodium arsenite (NaAsO2) exposure (postnatal) of rat pups. sodium arsenite 184-199 hippocalcin Rattus norvegicus 125-129 29630858-4 2018 The present study focused on determining the strategies that would modulate tissue redox status and calcium binding protein (CaBP) (Calbindin D28k-CB) expression affected adversely by sodium arsenite (NaAsO2) exposure (postnatal) of rat pups. sodium arsenite 184-199 calbindin 1 Rattus norvegicus 132-141 29630858-4 2018 The present study focused on determining the strategies that would modulate tissue redox status and calcium binding protein (CaBP) (Calbindin D28k-CB) expression affected adversely by sodium arsenite (NaAsO2) exposure (postnatal) of rat pups. sodium arsenite 201-207 hippocalcin Rattus norvegicus 100-123 29630858-4 2018 The present study focused on determining the strategies that would modulate tissue redox status and calcium binding protein (CaBP) (Calbindin D28k-CB) expression affected adversely by sodium arsenite (NaAsO2) exposure (postnatal) of rat pups. sodium arsenite 201-207 hippocalcin Rattus norvegicus 125-129 29630858-4 2018 The present study focused on determining the strategies that would modulate tissue redox status and calcium binding protein (CaBP) (Calbindin D28k-CB) expression affected adversely by sodium arsenite (NaAsO2) exposure (postnatal) of rat pups. sodium arsenite 201-207 calbindin 1 Rattus norvegicus 132-141 29630858-10 2018 The observations are suggestive of AOX induced restoration of CaBP expression in rat cerebellum following early postnatal exposure to NaAsO2. sodium arsenite 134-140 acyl-CoA oxidase 1 Rattus norvegicus 35-38 29630858-10 2018 The observations are suggestive of AOX induced restoration of CaBP expression in rat cerebellum following early postnatal exposure to NaAsO2. sodium arsenite 134-140 hippocalcin Rattus norvegicus 62-66 29723552-5 2018 Treatment with curcumin ameliorated sodium arsenite induced alterations in the levels of NMDA receptors, its receptor subunits and synaptic proteins - pCaMKIIalpha, PSD-95 and SynGAP both in vivo and in vitro. sodium arsenite 36-51 discs large MAGUK scaffold protein 4 Rattus norvegicus 165-171 29723552-5 2018 Treatment with curcumin ameliorated sodium arsenite induced alterations in the levels of NMDA receptors, its receptor subunits and synaptic proteins - pCaMKIIalpha, PSD-95 and SynGAP both in vivo and in vitro. sodium arsenite 36-51 synaptic Ras GTPase activating protein 1 Rattus norvegicus 176-182 29723552-6 2018 Decreased levels of BDNF, pAkt, pERK1/2, pGSK3beta and pCREB on sodium arsenite exposure were also protected by curcumin. sodium arsenite 64-79 brain-derived neurotrophic factor Rattus norvegicus 20-24 29723552-7 2018 Curcumin was found to decrease sodium arsenite induced changes in hippocampus by modulating PI3K/Akt/GSK3beta neuronal survival pathway, known to regulate various cellular events. sodium arsenite 31-46 AKT serine/threonine kinase 1 Rattus norvegicus 97-100 29723552-7 2018 Curcumin was found to decrease sodium arsenite induced changes in hippocampus by modulating PI3K/Akt/GSK3beta neuronal survival pathway, known to regulate various cellular events. sodium arsenite 31-46 glycogen synthase kinase 3 beta Rattus norvegicus 101-109 29725571-10 2018 GSTO1 mutant genotypes were found to have significant higher genotoxicity of sodium arsenite as compared to wild-type genotype. sodium arsenite 77-92 glutathione S-transferase omega 1 Homo sapiens 0-5 29725571-12 2018 A significant effect of GSTO1 polymorphism was observed on genotoxicity of sodium arsenite. sodium arsenite 75-90 glutathione S-transferase omega 1 Homo sapiens 24-29 29854073-4 2018 Significant activation of MAPK, NF-kappaB, p53, and intrinsic and extrinsic apoptotic signaling was observed in NaAsO2-exposed hepatic cells. sodium arsenite 112-118 transformation related protein 53, pseudogene Mus musculus 43-46 29526746-4 2018 Here we showed that NaAsO2 caused significant reduction in basal levels of glucose, plasma membrane glucose transporter, GLUT 3 and Akt phosphorylation in differentiated human neuroblastoma SH-SY5Y cells. sodium arsenite 20-26 solute carrier family 2 member 3 Homo sapiens 121-127 29526746-4 2018 Here we showed that NaAsO2 caused significant reduction in basal levels of glucose, plasma membrane glucose transporter, GLUT 3 and Akt phosphorylation in differentiated human neuroblastoma SH-SY5Y cells. sodium arsenite 20-26 AKT serine/threonine kinase 1 Homo sapiens 132-135 29526746-5 2018 NaAsO2 significantly decreased insulin-mediated glucose uptake, as well as GLUT1 and 3 membrane translocation. sodium arsenite 0-6 insulin Homo sapiens 31-38 29526746-6 2018 Furthermore, the ability of insulin to increase Akt phosphorylation, a well-recognized insulin signaling response, was significantly lessened by NaAsO2 treatment. sodium arsenite 145-151 insulin Homo sapiens 28-35 29526746-6 2018 Furthermore, the ability of insulin to increase Akt phosphorylation, a well-recognized insulin signaling response, was significantly lessened by NaAsO2 treatment. sodium arsenite 145-151 AKT serine/threonine kinase 1 Homo sapiens 48-51 29526746-6 2018 Furthermore, the ability of insulin to increase Akt phosphorylation, a well-recognized insulin signaling response, was significantly lessened by NaAsO2 treatment. sodium arsenite 145-151 insulin Homo sapiens 87-94 29526746-7 2018 In addition, the classical tyrosine phosphorylation response of insulin was reduced by NaAsO2, as evidenced by reduction of insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1(IRS-1). sodium arsenite 87-93 insulin Homo sapiens 64-71 29526746-7 2018 In addition, the classical tyrosine phosphorylation response of insulin was reduced by NaAsO2, as evidenced by reduction of insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1(IRS-1). sodium arsenite 87-93 insulin Homo sapiens 124-131 29526746-7 2018 In addition, the classical tyrosine phosphorylation response of insulin was reduced by NaAsO2, as evidenced by reduction of insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1(IRS-1). sodium arsenite 87-93 insulin Homo sapiens 124-131 29526746-7 2018 In addition, the classical tyrosine phosphorylation response of insulin was reduced by NaAsO2, as evidenced by reduction of insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1(IRS-1). sodium arsenite 87-93 insulin Homo sapiens 124-131 29526746-7 2018 In addition, the classical tyrosine phosphorylation response of insulin was reduced by NaAsO2, as evidenced by reduction of insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate-1(IRS-1). sodium arsenite 87-93 insulin receptor substrate 1 Homo sapiens 223-228 29526746-8 2018 Moreover, NaAsO2 lowered the ratio of p110, a catalytic subunit to p85, a regulatory subunit of PI3K causing an imbalance between p110 and p85, the conditions reported to contribute to insulin sensitivity. sodium arsenite 10-16 endogenous retrovirus group K member 15 Homo sapiens 38-42 29526746-8 2018 Moreover, NaAsO2 lowered the ratio of p110, a catalytic subunit to p85, a regulatory subunit of PI3K causing an imbalance between p110 and p85, the conditions reported to contribute to insulin sensitivity. sodium arsenite 10-16 phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens 67-70 29526746-8 2018 Moreover, NaAsO2 lowered the ratio of p110, a catalytic subunit to p85, a regulatory subunit of PI3K causing an imbalance between p110 and p85, the conditions reported to contribute to insulin sensitivity. sodium arsenite 10-16 endogenous retrovirus group K member 15 Homo sapiens 130-134 29526746-8 2018 Moreover, NaAsO2 lowered the ratio of p110, a catalytic subunit to p85, a regulatory subunit of PI3K causing an imbalance between p110 and p85, the conditions reported to contribute to insulin sensitivity. sodium arsenite 10-16 phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens 139-142 29526746-8 2018 Moreover, NaAsO2 lowered the ratio of p110, a catalytic subunit to p85, a regulatory subunit of PI3K causing an imbalance between p110 and p85, the conditions reported to contribute to insulin sensitivity. sodium arsenite 10-16 insulin Homo sapiens 185-192 29526746-9 2018 Additionally, increment of IRS-1 interaction with GSK3beta, and p85-PI3K were observed in NaAsO2 treated cells. sodium arsenite 90-96 insulin receptor substrate 1 Homo sapiens 27-32 29526746-9 2018 Additionally, increment of IRS-1 interaction with GSK3beta, and p85-PI3K were observed in NaAsO2 treated cells. sodium arsenite 90-96 glycogen synthase kinase 3 beta Homo sapiens 50-58 29526746-9 2018 Additionally, increment of IRS-1 interaction with GSK3beta, and p85-PI3K were observed in NaAsO2 treated cells. sodium arsenite 90-96 phosphoinositide-3-kinase regulatory subunit 2 Homo sapiens 64-67 29204679-5 2018 In CD-1 mice gestationally exposed to 20 ppm of sodium arsenite in drinking water, we have previously observed up-regulation of xCT in the male mouse hippocampus which caused glutamatergic synapse alterations affecting learning and memory processes. sodium arsenite 48-63 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 Mus musculus 128-131 29511641-6 2018 Rats fed with sodium arsenite exhibited a significant lessening in the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx). sodium arsenite 14-29 catalase Rattus norvegicus 113-121 29111283-6 2018 After treatment with NaAsO2, the p-PERK level in INS-1 rat pancreatic beta- cells was increased correspondingly. sodium arsenite 21-27 eukaryotic translation initiation factor 2 alpha kinase 3 Mus musculus 35-39 29111283-6 2018 After treatment with NaAsO2, the p-PERK level in INS-1 rat pancreatic beta- cells was increased correspondingly. sodium arsenite 21-27 insulin 1 Rattus norvegicus 49-54 29111283-9 2018 In NaAsO2-treated INS-1 cells, the initiation of ER stress preceded the stimulation of autophagy, which was a key factor controlling pancreatic beta cell function. sodium arsenite 3-9 insulin 1 Rattus norvegicus 18-23 29111283-10 2018 Furthermore, knockdown of PERK attenuated NaAsO2-induced autophagy in INS-1 cells. sodium arsenite 42-48 eukaryotic translation initiation factor 2 alpha kinase 3 Mus musculus 26-30 29111283-10 2018 Furthermore, knockdown of PERK attenuated NaAsO2-induced autophagy in INS-1 cells. sodium arsenite 42-48 insulin 1 Rattus norvegicus 70-75 29479036-3 2018 The effects of excess NaAsO2 on TNF-alpha response and its intracellular signaling are not well understood. sodium arsenite 22-28 tumor necrosis factor Homo sapiens 32-41 29479036-4 2018 We hypothesized that NaAsO2 exposure might affect cellular response to TNF-alpha. sodium arsenite 21-27 tumor necrosis factor Homo sapiens 71-80 29479036-5 2018 Using HeLa cell model, we found that the combination of NaAsO2 and TNF-alpha clearly decreased cell viability and mitochondrial membrane potential, but increased percentage of early and late apoptotic cells and cleaved-poly (ADP-ribose) polymerase (PARP). sodium arsenite 56-62 poly(ADP-ribose) polymerase 1 Homo sapiens 219-247 29479036-5 2018 Using HeLa cell model, we found that the combination of NaAsO2 and TNF-alpha clearly decreased cell viability and mitochondrial membrane potential, but increased percentage of early and late apoptotic cells and cleaved-poly (ADP-ribose) polymerase (PARP). sodium arsenite 56-62 poly(ADP-ribose) polymerase 1 Homo sapiens 249-253 29479036-6 2018 Moreover, the combination prolonged the phosphorylation of mitogen-activated protein kinase (MAPK) members, including c-Jun-N-terminal kinase (JNK), p38, and extracellular signal related kinases (ERK), and increased intracellular reactive oxygen species (ROS), in comparison to treatment of NaAsO2 or TNF-alpha alone. sodium arsenite 291-297 mitogen-activated protein kinase 1 Homo sapiens 93-97 29479036-11 2018 In conclusion, NaAsO2 exposure might amplify inflammation-related tissue injury by potentiating the apoptosis-inducing effect of TNF-alpha through ROS-dependent mechanism. sodium arsenite 15-21 tumor necrosis factor Homo sapiens 129-138 29233969-4 2017 When neurons are stressed such as by heat shock or sodium arsenite (As), cells engage specific proteosome-mediated degradation to reduce RIP140 level, thereby relieving the suppression and activating HSR. sodium arsenite 51-66 nuclear receptor interacting protein 1 Mus musculus 137-143 28974440-0 2017 Hijiki and sodium arsenite stimulate growth of human colorectal adenocarcinoma cells through ERK1/2 activation. sodium arsenite 11-26 mitogen-activated protein kinase 3 Homo sapiens 93-99 28974440-6 2017 Hijiki and sodium arsenite induced epidermal growth factor receptor (EGFR) and ERK1/2 activations. sodium arsenite 11-26 epidermal growth factor receptor Homo sapiens 35-67 28974440-6 2017 Hijiki and sodium arsenite induced epidermal growth factor receptor (EGFR) and ERK1/2 activations. sodium arsenite 11-26 epidermal growth factor receptor Homo sapiens 69-73 28974440-6 2017 Hijiki and sodium arsenite induced epidermal growth factor receptor (EGFR) and ERK1/2 activations. sodium arsenite 11-26 mitogen-activated protein kinase 3 Homo sapiens 79-85 28974440-7 2017 AG1478, an EGFR inhibitor, decreased the activation of EGFR and ERK1/2 induced by Hijiki and sodium arsenite. sodium arsenite 93-108 epidermal growth factor receptor Homo sapiens 11-15 28974440-7 2017 AG1478, an EGFR inhibitor, decreased the activation of EGFR and ERK1/2 induced by Hijiki and sodium arsenite. sodium arsenite 93-108 epidermal growth factor receptor Homo sapiens 55-59 28974440-7 2017 AG1478, an EGFR inhibitor, decreased the activation of EGFR and ERK1/2 induced by Hijiki and sodium arsenite. sodium arsenite 93-108 mitogen-activated protein kinase 3 Homo sapiens 64-70 28771313-4 2017 The biodisplay detected 10 mug/L sodium-arsenite in tap water using a research grade fluorescent microscope, and reported arsenic contamination down to 20 mug/L with an easy to interpret "skull and crossbones" symbol detectable with a low-cost USB microscope or by eye. sodium arsenite 33-48 nuclear RNA export factor 1 Homo sapiens 52-55 28843991-5 2017 Acute oral administration of NaAsO2 also raised pulmonary MPO activity and mRNA levels of chemokine Mip-2 and Mcp-1. sodium arsenite 29-35 chemokine (C-X-C motif) ligand 2 Mus musculus 100-105 28843991-5 2017 Acute oral administration of NaAsO2 also raised pulmonary MPO activity and mRNA levels of chemokine Mip-2 and Mcp-1. sodium arsenite 29-35 mast cell protease 1 Mus musculus 110-115 28366046-0 2017 Sodium arsenite-induced cardiovascular and renal dysfunction in rat via oxidative stress and protein kinase B (Akt/PKB) signaling pathway. sodium arsenite 0-15 AKT serine/threonine kinase 1 Rattus norvegicus 111-118 29044176-6 2017 Validation by western blot showed increased level of clathrin-associated sorting protein Disabled 2 (Dab2) in NaAsO2 group, indicating that it may regulate receptor endocytosis, which served as a mechanism to augment intracellular VEGF signaling. sodium arsenite 110-116 disabled 2, mitogen-responsive phosphoprotein Mus musculus 89-99 29044176-6 2017 Validation by western blot showed increased level of clathrin-associated sorting protein Disabled 2 (Dab2) in NaAsO2 group, indicating that it may regulate receptor endocytosis, which served as a mechanism to augment intracellular VEGF signaling. sodium arsenite 110-116 disabled 2, mitogen-responsive phosphoprotein Mus musculus 101-105 29044176-6 2017 Validation by western blot showed increased level of clathrin-associated sorting protein Disabled 2 (Dab2) in NaAsO2 group, indicating that it may regulate receptor endocytosis, which served as a mechanism to augment intracellular VEGF signaling. sodium arsenite 110-116 vascular endothelial growth factor A Mus musculus 231-235 29657918-8 2017 Histopathology and immunohistochemistry revealed varying degrees of recovery in hepatocyte ultrastructure alongside increased expression of the pro-survival protein Kinase B (Akt/PKB) after 4 weeks of NaAsO2 withdrawal. sodium arsenite 201-207 AKT serine/threonine kinase 1 Rattus norvegicus 175-182 28744533-9 2017 The experimental results show that TH287 is likely to inhibit MTH1 in tumor cells, rendering them more sensitive to NaAsO2. sodium arsenite 116-122 nudix hydrolase 1 Homo sapiens 62-66 28936164-6 2017 Moreover, sodium arsenite triggered unfolded protein response (UPR), leading to the phosphorylation of RNA-regulated protein kinase-like ER kinase (PERK) and eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha), and the induction of activating transcription factor 4 (ATF4). sodium arsenite 10-25 eukaryotic translation initiation factor 2 subunit alpha Rattus norvegicus 158-214 28936164-6 2017 Moreover, sodium arsenite triggered unfolded protein response (UPR), leading to the phosphorylation of RNA-regulated protein kinase-like ER kinase (PERK) and eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha), and the induction of activating transcription factor 4 (ATF4). sodium arsenite 10-25 eukaryotic translation initiation factor 2A Rattus norvegicus 216-225 28936164-6 2017 Moreover, sodium arsenite triggered unfolded protein response (UPR), leading to the phosphorylation of RNA-regulated protein kinase-like ER kinase (PERK) and eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha), and the induction of activating transcription factor 4 (ATF4). sodium arsenite 10-25 activating transcription factor 4 Rattus norvegicus 249-282 28936164-6 2017 Moreover, sodium arsenite triggered unfolded protein response (UPR), leading to the phosphorylation of RNA-regulated protein kinase-like ER kinase (PERK) and eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha), and the induction of activating transcription factor 4 (ATF4). sodium arsenite 10-25 activating transcription factor 4 Rattus norvegicus 284-288 28746394-5 2017 Moreover, we showed that SA and HS, but not H2O2, promote eIF2alpha phosphorylation in hiPSCs forming SGs. sodium arsenite 25-27 eukaryotic translation initiation factor 2A Homo sapiens 58-67 28715409-6 2017 We demonstrate that ZIKV negatively impacts SG assembly under oxidative stress conditions induced by sodium arsenite (Ars), a treatment that leads to the phosphorylation of eIF2alpha. sodium arsenite 101-116 eukaryotic translation initiation factor 2A Homo sapiens 173-182 28347842-3 2017 We examined the involvement of heme metabolism in the induction of HO-1 by the inducers sulforaphane and sodium arsenite. sodium arsenite 105-120 heme oxygenase 1 Homo sapiens 67-71 28347842-4 2017 METHODS: We examined the expression of HO-1 in sulforaphane-, sodium arsenite- and CORM3-treated HEK293T cells, by measuring the transcriptional activity and levels of mRNA and protein. sodium arsenite 62-77 heme oxygenase 1 Homo sapiens 39-43 27685703-6 2017 In vitro studies revealed an induction of ERCC2 hypermethylation and decreased mRNA expression in response to NaAsO2 treatment. sodium arsenite 110-116 ERCC excision repair 2, TFIIH core complex helicase subunit Homo sapiens 42-47 28225195-2 2017 Rats exposed to sodium arsenite (25 ppm for 8 weeks) showed decreased mitochondrial complexes (I, II, IV) activities, mitochondrial superoxide dismutase (MnSOD), and catalase activities in brain mitochondria. sodium arsenite 16-31 superoxide dismutase 2 Rattus norvegicus 118-152 28225195-2 2017 Rats exposed to sodium arsenite (25 ppm for 8 weeks) showed decreased mitochondrial complexes (I, II, IV) activities, mitochondrial superoxide dismutase (MnSOD), and catalase activities in brain mitochondria. sodium arsenite 16-31 superoxide dismutase 2 Rattus norvegicus 154-159 28225195-2 2017 Rats exposed to sodium arsenite (25 ppm for 8 weeks) showed decreased mitochondrial complexes (I, II, IV) activities, mitochondrial superoxide dismutase (MnSOD), and catalase activities in brain mitochondria. sodium arsenite 16-31 catalase Rattus norvegicus 166-174 28495450-4 2017 Secondly, in response to in vitro cellular stress (500muM sodium arsenite for 1h; or 400mM sorbitol 1 hour exposure; as an oxidative or osmotic stress, respectively), we observed a significant survival benefit in RGNEF-transfected HEK293T cells. sodium arsenite 58-73 Rho guanine nucleotide exchange factor 28 Homo sapiens 213-218 28556958-0 2017 Downregulation of androgen receptors by NaAsO2 via inhibition of AKT-NF-kappaB and HSP90 in castration resistant prostate cancer. sodium arsenite 40-46 AKT serine/threonine kinase 1 Homo sapiens 65-68 28556958-0 2017 Downregulation of androgen receptors by NaAsO2 via inhibition of AKT-NF-kappaB and HSP90 in castration resistant prostate cancer. sodium arsenite 40-46 nuclear factor kappa B subunit 1 Homo sapiens 69-78 28556958-0 2017 Downregulation of androgen receptors by NaAsO2 via inhibition of AKT-NF-kappaB and HSP90 in castration resistant prostate cancer. sodium arsenite 40-46 heat shock protein 90 alpha family class A member 1 Homo sapiens 83-88 28556958-5 2017 The aim of this study was to examine the effect of NaAsO2 on AR signaling in LNCaP and 22Rv1 CRPC cells. sodium arsenite 51-57 androgen receptor Homo sapiens 61-63 28556958-9 2017 RESULTS: NaAsO2 significantly reduced the translocation of AR and AR-Vs to the nucleus as well as their level in LNCaP and 22Rv1 cells. sodium arsenite 9-15 androgen receptor Homo sapiens 59-61 28556958-12 2017 NaAsO2 significantly inhibited phosphorylation of AKT and expression and nuclear translocation of NF-kappaB. sodium arsenite 0-6 AKT serine/threonine kinase 1 Homo sapiens 50-53 28556958-12 2017 NaAsO2 significantly inhibited phosphorylation of AKT and expression and nuclear translocation of NF-kappaB. sodium arsenite 0-6 nuclear factor kappa B subunit 1 Homo sapiens 98-107 28556958-14 2017 NaAsO2 promoted HSP90 acetylation by down-regulating HDAC6, which reduces the stability of AR in prostate cancer cells. sodium arsenite 0-6 heat shock protein 90 alpha family class A member 1 Homo sapiens 16-21 28556958-14 2017 NaAsO2 promoted HSP90 acetylation by down-regulating HDAC6, which reduces the stability of AR in prostate cancer cells. sodium arsenite 0-6 histone deacetylase 6 Homo sapiens 53-58 28556958-14 2017 NaAsO2 promoted HSP90 acetylation by down-regulating HDAC6, which reduces the stability of AR in prostate cancer cells. sodium arsenite 0-6 androgen receptor Homo sapiens 91-93 28556958-15 2017 CONCLUSIONS: Here, we show that NaAsO2 disrupts AR signaling at multiple levels by affecting AR expression, stability, and degradation in primary tumor cell cultures from prostate cancer patients as well as CRPC cell lines. sodium arsenite 32-38 androgen receptor Homo sapiens 48-50 28556958-15 2017 CONCLUSIONS: Here, we show that NaAsO2 disrupts AR signaling at multiple levels by affecting AR expression, stability, and degradation in primary tumor cell cultures from prostate cancer patients as well as CRPC cell lines. sodium arsenite 32-38 androgen receptor Homo sapiens 93-95 29029432-0 2017 The involvement of Nrf2 in the protective effects of (-)-Epigallocatechin-3-gallate (EGCG) on NaAsO2-induced hepatotoxicity. sodium arsenite 94-100 NFE2 like bZIP transcription factor 2 Homo sapiens 19-23 28726208-3 2017 Heme oxygenase 1, an inducible form of the enzyme, is normally not expressed in the cerebral vessels, but the enzyme is expressed in response to sodium metaarsenite. sodium arsenite 145-164 heme oxygenase 1 Rattus norvegicus 0-16 28726208-5 2017 Sodium meta-arsenite is inessential for immunolocation and quantitative distribution of heme oxygenase 2 in the vessels. sodium arsenite 0-20 heme oxygenase 2 Rattus norvegicus 88-104 28229933-5 2017 We investigated the activation of nuclear factor-E2-related factor 2 (Nrf2) which regulates various antioxidant genes including heme oxygenase-1 (HMOX1), following exposure to sodium arsenite or cadmium chloride in lamin knockdown human cell lines and primary HGPS human fibroblasts. sodium arsenite 176-191 NFE2 like bZIP transcription factor 2 Homo sapiens 70-74 28229933-5 2017 We investigated the activation of nuclear factor-E2-related factor 2 (Nrf2) which regulates various antioxidant genes including heme oxygenase-1 (HMOX1), following exposure to sodium arsenite or cadmium chloride in lamin knockdown human cell lines and primary HGPS human fibroblasts. sodium arsenite 176-191 heme oxygenase 1 Homo sapiens 128-144 28229933-5 2017 We investigated the activation of nuclear factor-E2-related factor 2 (Nrf2) which regulates various antioxidant genes including heme oxygenase-1 (HMOX1), following exposure to sodium arsenite or cadmium chloride in lamin knockdown human cell lines and primary HGPS human fibroblasts. sodium arsenite 176-191 heme oxygenase 1 Homo sapiens 146-151 28480809-6 2017 SA exposure also inhibited the pathways of glucose metabolism while increasing AMP deaminase and glyoxalase-I. sodium arsenite 0-2 glyoxalase I Homo sapiens 97-109 28189647-3 2017 Therefore, in this study we examined the effects of monomethylarsonous acid (MMA(III)) as compared to its parent compound sodium arsenite (As(III)) on the expression of CYP1A1 in HepG2 cells. sodium arsenite 122-137 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 169-175 28011284-8 2017 These data suggested that JNK-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP and facilitates the efficient recruitment of Tudor-SN into SGs under conditions of sodium arsenite-induced oxidative stress. sodium arsenite 198-213 mitogen-activated protein kinase 8 Homo sapiens 26-29 28011284-8 2017 These data suggested that JNK-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP and facilitates the efficient recruitment of Tudor-SN into SGs under conditions of sodium arsenite-induced oxidative stress. sodium arsenite 198-213 staphylococcal nuclease and tudor domain containing 1 Homo sapiens 39-47 28011284-8 2017 These data suggested that JNK-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP and facilitates the efficient recruitment of Tudor-SN into SGs under conditions of sodium arsenite-induced oxidative stress. sodium arsenite 198-213 staphylococcal nuclease and tudor domain containing 1 Homo sapiens 97-105 28011284-8 2017 These data suggested that JNK-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP and facilitates the efficient recruitment of Tudor-SN into SGs under conditions of sodium arsenite-induced oxidative stress. sodium arsenite 198-213 G3BP stress granule assembly factor 1 Homo sapiens 110-114 28011284-8 2017 These data suggested that JNK-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP and facilitates the efficient recruitment of Tudor-SN into SGs under conditions of sodium arsenite-induced oxidative stress. sodium arsenite 198-213 staphylococcal nuclease and tudor domain containing 1 Homo sapiens 97-105 27993642-8 2017 Atg7 and Atg12 levels were obviously higher in all groups treated with sodium arsenite compared to control. sodium arsenite 71-86 autophagy related 7 Rattus norvegicus 0-4 27993642-8 2017 Atg7 and Atg12 levels were obviously higher in all groups treated with sodium arsenite compared to control. sodium arsenite 71-86 autophagy related 12 Rattus norvegicus 9-14 28451559-0 2017 Effect of Sodium Arsenite on the Expression of Antioxidant Genes (SOD2 and CAT) in MCF-7 and Jurkat Cell Lines. sodium arsenite 10-25 superoxide dismutase 2 Homo sapiens 66-70 28451559-0 2017 Effect of Sodium Arsenite on the Expression of Antioxidant Genes (SOD2 and CAT) in MCF-7 and Jurkat Cell Lines. sodium arsenite 10-25 catalase Homo sapiens 75-78 28451559-3 2017 The purpose of the present study was to evaluate the alteration of mRNA levels of catalase (CAT) and superoxide dismutase 2 (SOD2) in MCF-7 and Jurkat cells after exposure to NaAsO2. sodium arsenite 175-181 catalase Homo sapiens 92-95 28451559-3 2017 The purpose of the present study was to evaluate the alteration of mRNA levels of catalase (CAT) and superoxide dismutase 2 (SOD2) in MCF-7 and Jurkat cells after exposure to NaAsO2. sodium arsenite 175-181 superoxide dismutase 2 Homo sapiens 101-123 28451559-3 2017 The purpose of the present study was to evaluate the alteration of mRNA levels of catalase (CAT) and superoxide dismutase 2 (SOD2) in MCF-7 and Jurkat cells after exposure to NaAsO2. sodium arsenite 175-181 superoxide dismutase 2 Homo sapiens 125-129 28451559-5 2017 For evaluating the expression levels of the CAT and SOD2, we used two concentrations of NaAsO2 (5 and 15 muM), lower than the concentrations at which 50% of cell viability were lost. sodium arsenite 88-94 catalase Homo sapiens 44-47 28451559-10 2017 RESULTS: CAT mRNA level decreased significantly in both cell lines following exposure to NaAsO2 (P<0.05). sodium arsenite 89-95 catalase Homo sapiens 9-12 28451559-11 2017 Expression levels of SOD2 decreased in Jurkat cells and increased in MCF-7 cells after treatment with NaAsO2 (P<0.05). sodium arsenite 102-108 superoxide dismutase 2 Homo sapiens 21-25 28451559-12 2017 CONCLUSION: After cells exposure to NaAsO2, CAT mRNA level decreased in both examined cell lines but the alterations of SOD2 mRNA level is cell specific. sodium arsenite 36-42 catalase Homo sapiens 44-47 28451559-12 2017 CONCLUSION: After cells exposure to NaAsO2, CAT mRNA level decreased in both examined cell lines but the alterations of SOD2 mRNA level is cell specific. sodium arsenite 36-42 superoxide dismutase 2 Homo sapiens 120-124 28451559-13 2017 The NAC modulated the NaAsO2 associated alterations of CAT and SOD2 mRNA levels, therefore, the NaAsO2 might act through inducing reactive oxygen species. sodium arsenite 22-28 catalase Homo sapiens 55-58 28451559-13 2017 The NAC modulated the NaAsO2 associated alterations of CAT and SOD2 mRNA levels, therefore, the NaAsO2 might act through inducing reactive oxygen species. sodium arsenite 22-28 superoxide dismutase 2 Homo sapiens 63-67 27884605-6 2017 Cells exposed to 10muM sodium arsenite increased the stability of HIPK1 and HIPK2 proteins, leading to CREB activation via Ser271 phosphorylation. sodium arsenite 23-38 cAMP responsive element binding protein 1 Homo sapiens 103-107 28791301-0 2017 Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats. sodium arsenite 31-46 vascular endothelial growth factor A Rattus norvegicus 65-69 28791301-0 2017 Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats. sodium arsenite 31-46 kinase insert domain receptor Rattus norvegicus 74-80 29209629-0 2017 Corrigendum to "Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats". sodium arsenite 47-62 vascular endothelial growth factor A Rattus norvegicus 81-85 29209629-0 2017 Corrigendum to "Effects of Chronic Exposure to Sodium Arsenite on Expressions of VEGF and VEGFR2 Proteins in the Epididymis of Rats". sodium arsenite 47-62 kinase insert domain receptor Rattus norvegicus 90-96 27620207-1 2016 PURPOSE: KML-001 (sodium metaarsenite) displaces hTERT from the nucleus and is synergistic with cisplatin. sodium arsenite 9-16 telomerase reverse transcriptase Homo sapiens 49-54 27620207-1 2016 PURPOSE: KML-001 (sodium metaarsenite) displaces hTERT from the nucleus and is synergistic with cisplatin. sodium arsenite 18-37 telomerase reverse transcriptase Homo sapiens 49-54 28007167-0 2016 Examination of in vivo mutagenicity of sodium arsenite and dimethylarsinic acid in gpt delta rats. sodium arsenite 39-54 glutamic--pyruvic transaminase Rattus norvegicus 83-86 28172957-5 2016 Under stress conditions induced by sodium arsenite, we found that in human fibroblasts TDP-43 did not translocate to the SGs but instead contributed to the SG formation through a regulatory effect on the G3BP1 core protein. sodium arsenite 35-50 TAR DNA binding protein Homo sapiens 87-93 28172957-5 2016 Under stress conditions induced by sodium arsenite, we found that in human fibroblasts TDP-43 did not translocate to the SGs but instead contributed to the SG formation through a regulatory effect on the G3BP1 core protein. sodium arsenite 35-50 G3BP stress granule assembly factor 1 Homo sapiens 204-209 27517564-4 2016 The effects of sodium arsenite treatment in CD133+CD13+ hepatocytes were mediated by the post-transcriptional suppression of PML expression and the inhibition of Oct4, Sox2, and Klf4 expression at the transcriptional level. sodium arsenite 15-30 prominin 1 Homo sapiens 44-49 27517564-4 2016 The effects of sodium arsenite treatment in CD133+CD13+ hepatocytes were mediated by the post-transcriptional suppression of PML expression and the inhibition of Oct4, Sox2, and Klf4 expression at the transcriptional level. sodium arsenite 15-30 alanyl aminopeptidase, membrane Homo sapiens 44-48 27517564-4 2016 The effects of sodium arsenite treatment in CD133+CD13+ hepatocytes were mediated by the post-transcriptional suppression of PML expression and the inhibition of Oct4, Sox2, and Klf4 expression at the transcriptional level. sodium arsenite 15-30 PML nuclear body scaffold Homo sapiens 125-128 27517564-4 2016 The effects of sodium arsenite treatment in CD133+CD13+ hepatocytes were mediated by the post-transcriptional suppression of PML expression and the inhibition of Oct4, Sox2, and Klf4 expression at the transcriptional level. sodium arsenite 15-30 POU class 5 homeobox 1 Homo sapiens 162-166 27517564-4 2016 The effects of sodium arsenite treatment in CD133+CD13+ hepatocytes were mediated by the post-transcriptional suppression of PML expression and the inhibition of Oct4, Sox2, and Klf4 expression at the transcriptional level. sodium arsenite 15-30 SRY-box transcription factor 2 Homo sapiens 168-172 27517564-4 2016 The effects of sodium arsenite treatment in CD133+CD13+ hepatocytes were mediated by the post-transcriptional suppression of PML expression and the inhibition of Oct4, Sox2, and Klf4 expression at the transcriptional level. sodium arsenite 15-30 Kruppel like factor 4 Homo sapiens 178-182 25728338-0 2016 Sodium arsenite inhibited genomic estrogen signaling but induced pERalpha (Ser118) via MAPK pathway in breast cancer cells. sodium arsenite 0-15 mitogen-activated protein kinase 3 Homo sapiens 87-91 25728338-4 2016 The results demonstrated that NaAsO2 dose-dependently increased viability of hormone-dependent breast cancer MCF-7 and T47D cells expressing both ERalpha and ERbeta but not hormone-independent MDA-MB-231 cells expressing ERbeta. sodium arsenite 30-36 estrogen receptor 1 Homo sapiens 146-153 25728338-4 2016 The results demonstrated that NaAsO2 dose-dependently increased viability of hormone-dependent breast cancer MCF-7 and T47D cells expressing both ERalpha and ERbeta but not hormone-independent MDA-MB-231 cells expressing ERbeta. sodium arsenite 30-36 estrogen receptor 2 Homo sapiens 158-164 25728338-5 2016 These suggested ERalpha contribution to NaAsO2 -stimulated breast cancer cells growth. sodium arsenite 40-46 estrogen receptor 1 Homo sapiens 16-23 25728338-6 2016 NaAsO2 induced down-regulation of ERalpha but up-regulation of ERbeta protein expressions in T47D cells. sodium arsenite 0-6 estrogen receptor 1 Homo sapiens 34-41 25728338-6 2016 NaAsO2 induced down-regulation of ERalpha but up-regulation of ERbeta protein expressions in T47D cells. sodium arsenite 0-6 estrogen receptor 2 Homo sapiens 63-69 25728338-7 2016 Moreover, NaAsO2 dose-dependently inhibited E2-induced ER transcriptional activity as it decreased E2-mediated ERE-luciferase transcription activation and PgR mRNA transcription but increased pS2 mRNA transcription. sodium arsenite 10-16 progesterone receptor Homo sapiens 155-158 25728338-7 2016 Moreover, NaAsO2 dose-dependently inhibited E2-induced ER transcriptional activity as it decreased E2-mediated ERE-luciferase transcription activation and PgR mRNA transcription but increased pS2 mRNA transcription. sodium arsenite 10-16 trefoil factor 1 Homo sapiens 192-195 25728338-8 2016 However, NaAsO2 induced both rapid and sustained activation of ERK1/2 and increased in phosphorylation of ERalpha at serine 118 residue, c-fos and c-myc protein expressions. sodium arsenite 9-15 mitogen-activated protein kinase 3 Homo sapiens 63-69 25728338-8 2016 However, NaAsO2 induced both rapid and sustained activation of ERK1/2 and increased in phosphorylation of ERalpha at serine 118 residue, c-fos and c-myc protein expressions. sodium arsenite 9-15 estrogen receptor 1 Homo sapiens 106-113 25728338-8 2016 However, NaAsO2 induced both rapid and sustained activation of ERK1/2 and increased in phosphorylation of ERalpha at serine 118 residue, c-fos and c-myc protein expressions. sodium arsenite 9-15 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens 137-142 25728338-8 2016 However, NaAsO2 induced both rapid and sustained activation of ERK1/2 and increased in phosphorylation of ERalpha at serine 118 residue, c-fos and c-myc protein expressions. sodium arsenite 9-15 MYC proto-oncogene, bHLH transcription factor Homo sapiens 147-152 25728338-9 2016 These results indicated that NaAsO2 interferes the genomic estrogen-signaling pathway but induces activation of a rapid nongenomic signal transduction through ERK1/2 pathway which may contribute to its proliferative effect on hormone-dependent breast cancer cells. sodium arsenite 29-35 mitogen-activated protein kinase 3 Homo sapiens 159-165 27129674-6 2016 Our data revealed that treatment with high concentration of sodium arsenite increased caspase-3 cleavage and NF-kappaB level, 9days after injection. sodium arsenite 60-75 caspase 3 Rattus norvegicus 86-95 27129674-7 2016 Whereas, low doses of sodium arsenite cause Nrf2 and HO-1 activation and increased CREB phosphorylation in the hippocampus. sodium arsenite 22-37 NFE2 like bZIP transcription factor 2 Rattus norvegicus 44-48 27129674-7 2016 Whereas, low doses of sodium arsenite cause Nrf2 and HO-1 activation and increased CREB phosphorylation in the hippocampus. sodium arsenite 22-37 heme oxygenase 1 Rattus norvegicus 53-57 27129674-7 2016 Whereas, low doses of sodium arsenite cause Nrf2 and HO-1 activation and increased CREB phosphorylation in the hippocampus. sodium arsenite 22-37 cAMP responsive element binding protein 1 Rattus norvegicus 83-87 27129674-9 2016 Moreover, it seems that the neuroprotective effects of ultra-low concentrations of sodium arsenite on Abeta-induced memory impairment is mediated via an increase Nrf2, HO-1 and CREB phosphorylation levels and decrease caspase-3 and NF-kappaB amount. sodium arsenite 83-98 NFE2 like bZIP transcription factor 2 Rattus norvegicus 162-166 27129674-9 2016 Moreover, it seems that the neuroprotective effects of ultra-low concentrations of sodium arsenite on Abeta-induced memory impairment is mediated via an increase Nrf2, HO-1 and CREB phosphorylation levels and decrease caspase-3 and NF-kappaB amount. sodium arsenite 83-98 heme oxygenase 1 Rattus norvegicus 168-172 27129674-9 2016 Moreover, it seems that the neuroprotective effects of ultra-low concentrations of sodium arsenite on Abeta-induced memory impairment is mediated via an increase Nrf2, HO-1 and CREB phosphorylation levels and decrease caspase-3 and NF-kappaB amount. sodium arsenite 83-98 cAMP responsive element binding protein 1 Rattus norvegicus 177-181 27129674-9 2016 Moreover, it seems that the neuroprotective effects of ultra-low concentrations of sodium arsenite on Abeta-induced memory impairment is mediated via an increase Nrf2, HO-1 and CREB phosphorylation levels and decrease caspase-3 and NF-kappaB amount. sodium arsenite 83-98 caspase 3 Rattus norvegicus 218-227 27306194-0 2016 Nrf2-dependent protection against acute sodium arsenite toxicity in zebrafish. sodium arsenite 40-55 nfe2 like bZIP transcription factor 2a Danio rerio 0-4 27306194-3 2016 In the present study, we genetically investigated the protective role of Nrf2 against acute sodium arsenite toxicity using the zebrafish Nrf2 mutant, nrf2a(fh318). sodium arsenite 92-107 nfe2 like bZIP transcription factor 2a Danio rerio 73-77 27306194-4 2016 After treatment with 1mM sodium arsenite, the survival of nrf2a(fh318) larvae was significantly shorter than that of wild-type siblings, suggesting that Nrf2 protected the zebrafish larvae against high-dose arsenite exposure. sodium arsenite 25-40 nfe2 like bZIP transcription factor 2a Danio rerio 153-157 27306194-7 2016 Based on these results, we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity. sodium arsenite 114-129 nfe2 like bZIP transcription factor 2a Danio rerio 42-46 27165637-3 2016 In the present study, mice were used as a model to investigate the oxidative stress levels and the expressions of NRF2-regulated antioxidant substances in both cerebral cortex and hippocampus with 5, 10 and 20 mg/kg NaAsO2 exposure intra-gastrically. sodium arsenite 216-222 nuclear factor, erythroid derived 2, like 2 Mus musculus 114-118 27165637-5 2016 We also detected rapidly elevation of NRF2 protein levels by enhancement of Nrf2 transcription, especially at 20 mg/kg NaAsO2 exposure group. sodium arsenite 119-125 nuclear factor, erythroid derived 2, like 2 Mus musculus 38-42 27165637-5 2016 We also detected rapidly elevation of NRF2 protein levels by enhancement of Nrf2 transcription, especially at 20 mg/kg NaAsO2 exposure group. sodium arsenite 119-125 nuclear factor, erythroid derived 2, like 2 Mus musculus 76-80 27132035-5 2016 After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3). sodium arsenite 6-12 microRNA 4255 Homo sapiens 51-66 27132035-5 2016 After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3). sodium arsenite 6-12 microRNA 4255 Homo sapiens 68-78 27132035-5 2016 After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3). sodium arsenite 6-12 microRNA 4255 Homo sapiens 136-146 27132035-5 2016 After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3). sodium arsenite 6-12 programmed cell death 10 Homo sapiens 219-252 27132035-5 2016 After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3). sodium arsenite 6-12 programmed cell death 10 Homo sapiens 254-258 27132035-5 2016 After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3). sodium arsenite 160-166 microRNA 4255 Homo sapiens 51-66 27132035-5 2016 After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3). sodium arsenite 160-166 microRNA 4255 Homo sapiens 68-78 27132035-5 2016 After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3). sodium arsenite 160-166 microRNA 4255 Homo sapiens 136-146 27132035-5 2016 After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3). sodium arsenite 160-166 programmed cell death 10 Homo sapiens 219-252 27132035-5 2016 After NaAsO2 treatment, we found the expression of microRNA-425-5p (miR-425-5p) was reduced in vitro and in vivo and over-expression of miR-425-5p reversed the NaAsO2-induced anti-angiogenesis through its direct target cerebral cavernous malformation 3 (CCM3). sodium arsenite 160-166 programmed cell death 10 Homo sapiens 254-258 27132035-6 2016 Furthermore, we showed that NaAsO2 up-regulated CCM3 expression in vitro and in vivo. sodium arsenite 28-34 programmed cell death 10 Homo sapiens 48-52 27132035-7 2016 In addition, we demonstrated that inhibition of Notch and activation of VEGF/p38 signaling were involved in miR-425-5p blocking NaAsO2-induced anti-angiogenesis. sodium arsenite 128-134 mitogen-activated protein kinase 14 Homo sapiens 77-80 27132035-7 2016 In addition, we demonstrated that inhibition of Notch and activation of VEGF/p38 signaling were involved in miR-425-5p blocking NaAsO2-induced anti-angiogenesis. sodium arsenite 128-134 microRNA 4255 Homo sapiens 108-118 26984302-4 2016 The aim of the present study was to explore the role of a Obg-like ATPase1 (OLA1) in the cell transformation of BALB/c 3T3 A31-1-1 clonal cells induced by a metal mixture (2 microM NaAsO2, 2 microM CdCl2 and 5 microM Pb(C2H3O2)2 3H2O) through ROS generation. sodium arsenite 181-187 Obg-like ATPase 1 Mus musculus 58-74 26984302-4 2016 The aim of the present study was to explore the role of a Obg-like ATPase1 (OLA1) in the cell transformation of BALB/c 3T3 A31-1-1 clonal cells induced by a metal mixture (2 microM NaAsO2, 2 microM CdCl2 and 5 microM Pb(C2H3O2)2 3H2O) through ROS generation. sodium arsenite 181-187 Obg-like ATPase 1 Mus musculus 76-80 26066906-7 2016 In addition, NaAsO2 significantly (P<0.05-0.01) altered the expression of intrinsic (Bad , Bcl-2 , cleaved-caspase 3 and cleaved-caspase 9 ) and extrinsic (Fas , Bid , cleaved-caspase 8 ) transcription proteins participating in the apoptotic event. sodium arsenite 13-19 B cell leukemia/lymphoma 2 Mus musculus 94-99 26066906-7 2016 In addition, NaAsO2 significantly (P<0.05-0.01) altered the expression of intrinsic (Bad , Bcl-2 , cleaved-caspase 3 and cleaved-caspase 9 ) and extrinsic (Fas , Bid , cleaved-caspase 8 ) transcription proteins participating in the apoptotic event. sodium arsenite 13-19 caspase 9 Mus musculus 133-142 26066906-7 2016 In addition, NaAsO2 significantly (P<0.05-0.01) altered the expression of intrinsic (Bad , Bcl-2 , cleaved-caspase 3 and cleaved-caspase 9 ) and extrinsic (Fas , Bid , cleaved-caspase 8 ) transcription proteins participating in the apoptotic event. sodium arsenite 13-19 BH3 interacting domain death agonist Mus musculus 166-169 26066906-7 2016 In addition, NaAsO2 significantly (P<0.05-0.01) altered the expression of intrinsic (Bad , Bcl-2 , cleaved-caspase 3 and cleaved-caspase 9 ) and extrinsic (Fas , Bid , cleaved-caspase 8 ) transcription proteins participating in the apoptotic event. sodium arsenite 13-19 caspase 8 Mus musculus 180-189 27071941-6 2016 Inhibitor studies suggest that rapid MAPK phosphorylation by NaAsO2, CdCl2, and E2 involves ER, Src, epidermal growth factor receptor, and G-protein coupled ER (GPER) in a pertussis toxin-sensitive pathway. sodium arsenite 61-67 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 96-99 27071941-6 2016 Inhibitor studies suggest that rapid MAPK phosphorylation by NaAsO2, CdCl2, and E2 involves ER, Src, epidermal growth factor receptor, and G-protein coupled ER (GPER) in a pertussis toxin-sensitive pathway. sodium arsenite 61-67 epidermal growth factor receptor Homo sapiens 101-133 27071941-6 2016 Inhibitor studies suggest that rapid MAPK phosphorylation by NaAsO2, CdCl2, and E2 involves ER, Src, epidermal growth factor receptor, and G-protein coupled ER (GPER) in a pertussis toxin-sensitive pathway. sodium arsenite 61-67 G protein-coupled estrogen receptor 1 Homo sapiens 139-159 27071941-6 2016 Inhibitor studies suggest that rapid MAPK phosphorylation by NaAsO2, CdCl2, and E2 involves ER, Src, epidermal growth factor receptor, and G-protein coupled ER (GPER) in a pertussis toxin-sensitive pathway. sodium arsenite 61-67 G protein-coupled estrogen receptor 1 Homo sapiens 161-165 27071941-8 2016 This study supports the involvement of membrane ER and GPER signaling in mediating cellular responses to environmentally relevant nM concentrations of CdCl2 and NaAsO2 in lung adenocarcinoma cells. sodium arsenite 161-167 G protein-coupled estrogen receptor 1 Homo sapiens 55-59 26349760-9 2016 Furthermore, NaAsO2 administration increased serum values of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and bilirubin. sodium arsenite 13-19 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 93-119 26349760-9 2016 Furthermore, NaAsO2 administration increased serum values of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and bilirubin. sodium arsenite 13-19 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 121-124 27459794-3 2016 Western blot was used to evaluate the expression of Nrf2, quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (10-1) during sodium arsenite-induced transformation of HBE cells. sodium arsenite 125-140 NFE2 like bZIP transcription factor 2 Homo sapiens 52-56 27459794-3 2016 Western blot was used to evaluate the expression of Nrf2, quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (10-1) during sodium arsenite-induced transformation of HBE cells. sodium arsenite 125-140 NAD(P)H quinone dehydrogenase 1 Homo sapiens 84-88 27459794-3 2016 Western blot was used to evaluate the expression of Nrf2, quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (10-1) during sodium arsenite-induced transformation of HBE cells. sodium arsenite 125-140 heme oxygenase 1 Homo sapiens 94-110 27459794-7 2016 CONCLUSION: The transformation of HBE cells induced by chronic exposure to sodium arsenite is mediated by decreased Nrf2 level and its downstream NQO1 and HO-1 protein, which subsequently promote the malignant proliferation. sodium arsenite 75-90 NFE2 like bZIP transcription factor 2 Homo sapiens 116-120 27459794-7 2016 CONCLUSION: The transformation of HBE cells induced by chronic exposure to sodium arsenite is mediated by decreased Nrf2 level and its downstream NQO1 and HO-1 protein, which subsequently promote the malignant proliferation. sodium arsenite 75-90 NAD(P)H quinone dehydrogenase 1 Homo sapiens 146-150 27459794-7 2016 CONCLUSION: The transformation of HBE cells induced by chronic exposure to sodium arsenite is mediated by decreased Nrf2 level and its downstream NQO1 and HO-1 protein, which subsequently promote the malignant proliferation. sodium arsenite 75-90 heme oxygenase 1 Homo sapiens 155-159 25787150-4 2016 The results demonstrated that exposure to 10 muM sodium arsenite up to 14 days induces a great increase in G0/G1 arrest, irreversible cell growth suppression, cellular morphological changes and positive staining for senescence-associated beta-galactosidase. sodium arsenite 49-64 galactosidase, beta 1 Mus musculus 238-256 26231544-2 2016 Expressions of Rac1 and Cdc42 in rat cerebellum and cerebrum exposed to different doses of NaAsO2 (Wistar rats drank 0, 2, 10, and 50 mg/L NaAsO2 water for 3 months) were examined. sodium arsenite 91-97 Rac family small GTPase 1 Rattus norvegicus 15-19 26231544-5 2016 Rac1 inhibitor, NSC23766, decreased NaAsO2-induced apoptosis and increased the cell viability in primary cultured rat cerebellar astrocytes exposed to 30 muM NaAsO2. sodium arsenite 36-42 Rac family small GTPase 1 Rattus norvegicus 0-4 26231544-5 2016 Rac1 inhibitor, NSC23766, decreased NaAsO2-induced apoptosis and increased the cell viability in primary cultured rat cerebellar astrocytes exposed to 30 muM NaAsO2. sodium arsenite 158-164 Rac family small GTPase 1 Rattus norvegicus 0-4 26231544-6 2016 Cdc42 inhibitor, ZCL278, increased cell viability in the cells exposed to 30 muM NaAsO2. sodium arsenite 81-87 cell division cycle 42 Rattus norvegicus 0-5 26497187-3 2016 Sodium arsenite (1.5 mg/kg, i.p., 2 weeks) abrogated the acetylcholine-induced, endothelium-dependent vasorelaxation by depicting the decrease in serum nitrite/nitrate concentration, reduced glutathione level, and simultaneously enhance the thiobarbituric acid reactive substances (TBARS) level, superoxide level, and tumor necrosis factor-alpha. sodium arsenite 0-15 tumor necrosis factor Homo sapiens 318-345 26631322-7 2016 NaAsO2 suppressed the autophagic flux in tubular cells through the activation of ERK. sodium arsenite 0-6 mitogen-activated protein kinase 1 Mus musculus 81-84 26631322-9 2016 The IL-6/STAT3 signaling pathway had protective roles in NaAsO2-induced nephrotoxicity through the suppression of ERK activation. sodium arsenite 57-63 interleukin 6 Mus musculus 4-8 26631322-9 2016 The IL-6/STAT3 signaling pathway had protective roles in NaAsO2-induced nephrotoxicity through the suppression of ERK activation. sodium arsenite 57-63 signal transducer and activator of transcription 3 Mus musculus 9-14 26631322-9 2016 The IL-6/STAT3 signaling pathway had protective roles in NaAsO2-induced nephrotoxicity through the suppression of ERK activation. sodium arsenite 57-63 mitogen-activated protein kinase 1 Mus musculus 114-117 26432159-4 2015 This study found that cells treated with sodium arsenite had reduced 8-oxoguanine DNA glycosylase 1 (OGG1) and increased 8-hydroxy-2"-deoxyguanosine (8-OHdG) and activating transcription factor (ATF) 3 in SV-40 immortalized human uroepithelial (SV-HUC-1) cells. sodium arsenite 41-56 8-oxoguanine DNA glycosylase Homo sapiens 69-99 26432159-4 2015 This study found that cells treated with sodium arsenite had reduced 8-oxoguanine DNA glycosylase 1 (OGG1) and increased 8-hydroxy-2"-deoxyguanosine (8-OHdG) and activating transcription factor (ATF) 3 in SV-40 immortalized human uroepithelial (SV-HUC-1) cells. sodium arsenite 41-56 8-oxoguanine DNA glycosylase Homo sapiens 101-105 26432159-4 2015 This study found that cells treated with sodium arsenite had reduced 8-oxoguanine DNA glycosylase 1 (OGG1) and increased 8-hydroxy-2"-deoxyguanosine (8-OHdG) and activating transcription factor (ATF) 3 in SV-40 immortalized human uroepithelial (SV-HUC-1) cells. sodium arsenite 41-56 activating transcription factor 3 Homo sapiens 162-201 26485141-7 2015 Sodium arsenite at a dose of 40 mg/L supplied via drinking water in mice significantly raised the serum level of liver function markers such as AST, ALT, and ALP, and caused arsenic deposition in liver and ROS generation, though it did not show any lethality up to 30 days of exposure. sodium arsenite 0-15 transmembrane protease, serine 11d Mus musculus 144-147 26485141-7 2015 Sodium arsenite at a dose of 40 mg/L supplied via drinking water in mice significantly raised the serum level of liver function markers such as AST, ALT, and ALP, and caused arsenic deposition in liver and ROS generation, though it did not show any lethality up to 30 days of exposure. sodium arsenite 0-15 glutamic pyruvic transaminase, soluble Mus musculus 149-152 26528920-6 2015 In ~80% of cells treated with sodium arsenite (Ars) to induce cytoplasmic stress granules, the nuclear localization of WT and F115C mutant Matrin 3 was not disturbed. sodium arsenite 30-45 matrin 3 Homo sapiens 139-147 26260897-1 2015 In the present study, treatment of Xenopus laevis A6 kidney epithelial cells with the proteasomal inhibitor, MG132, or the environmental toxicants, sodium arsenite or cadmium chloride, induced the accumulation of the small heat shock protein, HSP30, in total and in both soluble and insoluble protein fractions. sodium arsenite 148-163 heat shock 70kDa protein L homeolog Xenopus laevis 223-241 26260897-1 2015 In the present study, treatment of Xenopus laevis A6 kidney epithelial cells with the proteasomal inhibitor, MG132, or the environmental toxicants, sodium arsenite or cadmium chloride, induced the accumulation of the small heat shock protein, HSP30, in total and in both soluble and insoluble protein fractions. sodium arsenite 148-163 heat shock protein 30E L homeolog Xenopus laevis 243-248 26259607-10 2015 The increases of HSPA8 and ENO1 levels were also detected in CM of HK-2 cells treated with other nephrotoxic agents, such as HgCl2, NaAsO2, cisplatin, amphotericin B, and cyclosporine A. sodium arsenite 132-138 heat shock protein family A (Hsp70) member 8 Homo sapiens 17-22 26259607-10 2015 The increases of HSPA8 and ENO1 levels were also detected in CM of HK-2 cells treated with other nephrotoxic agents, such as HgCl2, NaAsO2, cisplatin, amphotericin B, and cyclosporine A. sodium arsenite 132-138 enolase 1 Homo sapiens 27-31 26341012-11 2015 Plumbagin, and the GR inhibitor sodium arsenite all increased intracellular reactive oxygen species (ROS) levels and this increase was significantly attenuated by pretreatment with the ROS scavenger N-acetyl-cysteine (NAC) in HepG2 cells. sodium arsenite 32-47 glutathione-disulfide reductase Homo sapiens 19-21 26473898-5 2015 Our results showed 10 mg/kg NaAsO2 elevated the NRF2 protein and increased the transcription of Nrf2 mRNA, as well as up-regulated NRF2 downstream targets HO-1, GST and GCLC time- and dose-dependently both in the liver and kidney. sodium arsenite 28-34 nuclear factor, erythroid derived 2, like 2 Mus musculus 48-52 26473898-5 2015 Our results showed 10 mg/kg NaAsO2 elevated the NRF2 protein and increased the transcription of Nrf2 mRNA, as well as up-regulated NRF2 downstream targets HO-1, GST and GCLC time- and dose-dependently both in the liver and kidney. sodium arsenite 28-34 nuclear factor, erythroid derived 2, like 2 Mus musculus 96-100 26473898-5 2015 Our results showed 10 mg/kg NaAsO2 elevated the NRF2 protein and increased the transcription of Nrf2 mRNA, as well as up-regulated NRF2 downstream targets HO-1, GST and GCLC time- and dose-dependently both in the liver and kidney. sodium arsenite 28-34 nuclear factor, erythroid derived 2, like 2 Mus musculus 131-135 26473898-5 2015 Our results showed 10 mg/kg NaAsO2 elevated the NRF2 protein and increased the transcription of Nrf2 mRNA, as well as up-regulated NRF2 downstream targets HO-1, GST and GCLC time- and dose-dependently both in the liver and kidney. sodium arsenite 28-34 heme oxygenase 1 Mus musculus 155-159 26473898-5 2015 Our results showed 10 mg/kg NaAsO2 elevated the NRF2 protein and increased the transcription of Nrf2 mRNA, as well as up-regulated NRF2 downstream targets HO-1, GST and GCLC time- and dose-dependently both in the liver and kidney. sodium arsenite 28-34 glutamate-cysteine ligase, catalytic subunit Mus musculus 169-173 26870803-2 2015 In this study, we show that microglia stressed by exposure to sodium arsenite or Abeta(1-42) peptides or fibrils form extensive stress granules (SGs) to which the tyrosine kinase, SYK, is recruited. sodium arsenite 62-77 spleen associated tyrosine kinase Homo sapiens 180-183 26371860-3 2015 Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h. sodium arsenite 48-63 nuclear factor, erythroid derived 2, like 2 Mus musculus 131-135 26371860-3 2015 Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h. sodium arsenite 48-63 heme oxygenase 1 Mus musculus 163-179 26371860-3 2015 Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h. sodium arsenite 48-63 heme oxygenase 1 Mus musculus 181-185 26371860-3 2015 Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h. sodium arsenite 48-63 hematopoietic prostaglandin D synthase Mus musculus 188-213 26371860-3 2015 Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h. sodium arsenite 48-63 hematopoietic prostaglandin D synthase Mus musculus 215-218 26371860-3 2015 Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h. sodium arsenite 48-63 glutathione reductase Mus musculus 257-278 26371860-3 2015 Our results showed that treatment with arsenic (sodium arsenite, 5, 10 and 20mg/kg, intra-gastrically) increased the expression of NRF2 and its downstream targets heme oxygenase-1 (HO-1), glutathione-S-transferase (GST), glutamate-cysteine ligase (GCL) and glutathione reductase (GR) consistently in spleen, thymus, as well as peripheral blood mononuclear cells (PBMCs), as early as treatment from 6h. sodium arsenite 48-63 glutathione reductase Mus musculus 280-282 26291581-0 2015 Low-level sodium arsenite induces apoptosis through inhibiting TrxR activity in pancreatic beta-cells. sodium arsenite 10-25 peroxiredoxin 5 Rattus norvegicus 63-67 26291581-2 2015 Since the thioredoxin (Trx) system is the key antioxidant factor in mammalian cells, we investigate whether the inhibition of Trx system contributes to sodium arsenite-induced apoptosis in this study. sodium arsenite 152-167 thioredoxin Homo sapiens 126-129 26291581-3 2015 After treatment with low-level (0.25-1muM) sodium arsenite for 96h, the thioredoxin reductase (TrxR) activity was decreased significantly in pancreatic INS-1 cells. sodium arsenite 43-58 peroxiredoxin 5 Rattus norvegicus 72-93 26291581-3 2015 After treatment with low-level (0.25-1muM) sodium arsenite for 96h, the thioredoxin reductase (TrxR) activity was decreased significantly in pancreatic INS-1 cells. sodium arsenite 43-58 peroxiredoxin 5 Rattus norvegicus 95-99 26291581-4 2015 Following with the inactivation of TrxR, ASK1 was released from combining with Trx, which was evidenced by increased levels of ASK1 in sodium arsenite-treated INS-1 cells. sodium arsenite 135-150 peroxiredoxin 5 Rattus norvegicus 35-39 26291581-4 2015 Following with the inactivation of TrxR, ASK1 was released from combining with Trx, which was evidenced by increased levels of ASK1 in sodium arsenite-treated INS-1 cells. sodium arsenite 135-150 mitogen-activated protein kinase kinase kinase 5 Rattus norvegicus 41-45 26291581-4 2015 Following with the inactivation of TrxR, ASK1 was released from combining with Trx, which was evidenced by increased levels of ASK1 in sodium arsenite-treated INS-1 cells. sodium arsenite 135-150 thioredoxin 1 Rattus norvegicus 35-38 26291581-4 2015 Following with the inactivation of TrxR, ASK1 was released from combining with Trx, which was evidenced by increased levels of ASK1 in sodium arsenite-treated INS-1 cells. sodium arsenite 135-150 mitogen-activated protein kinase kinase kinase 5 Rattus norvegicus 127-131 26291581-6 2015 Finally, low-level sodium arsenite induced apoptosis via caspase-3 in INS-1 cells. sodium arsenite 19-34 caspase 3 Rattus norvegicus 57-66 26291581-7 2015 Knockdown of ASK1 alleviated sodium arsenite-induced apoptosis. sodium arsenite 29-44 mitogen-activated protein kinase kinase kinase 5 Rattus norvegicus 13-17 26066304-3 2015 Here we show that noncytotoxic exposure to sodium meta-arsenite (NaAsO2) inducing redox imbalance is able to increase the CRYAB content of C2C12 myoblasts in a transcription-dependent manner. sodium arsenite 43-63 crystallin, alpha B Mus musculus 122-127 26066304-3 2015 Here we show that noncytotoxic exposure to sodium meta-arsenite (NaAsO2) inducing redox imbalance is able to increase the CRYAB content of C2C12 myoblasts in a transcription-dependent manner. sodium arsenite 65-71 crystallin, alpha B Mus musculus 122-127 26066304-5 2015 The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance. sodium arsenite 109-115 nuclear factor, erythroid derived 2, like 2 Mus musculus 42-46 26066304-5 2015 The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance. sodium arsenite 109-115 jun proto-oncogene Mus musculus 55-59 26066304-5 2015 The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance. sodium arsenite 109-115 jun proto-oncogene Mus musculus 70-75 26066304-5 2015 The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance. sodium arsenite 109-115 jun proto-oncogene Mus musculus 190-195 26066304-5 2015 The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance. sodium arsenite 109-115 nuclear factor, erythroid derived 2, like 2 Mus musculus 200-204 26066304-5 2015 The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance. sodium arsenite 109-115 crystallin, alpha B Mus musculus 297-302 26066304-5 2015 The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance. sodium arsenite 162-168 nuclear factor, erythroid derived 2, like 2 Mus musculus 42-46 26066304-5 2015 The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance. sodium arsenite 162-168 jun proto-oncogene Mus musculus 55-59 26066304-5 2015 The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance. sodium arsenite 162-168 jun proto-oncogene Mus musculus 70-75 26066304-5 2015 The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance. sodium arsenite 162-168 jun proto-oncogene Mus musculus 190-195 26066304-5 2015 The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance. sodium arsenite 162-168 nuclear factor, erythroid derived 2, like 2 Mus musculus 200-204 26066304-5 2015 The redox-sensitive transcription factors Nrf2 and the AP-1 component c-Jun were found to be up-regulated in NaAsO2-treated cells, and we demonstrated a specific NaAsO2-mediated increase of c-Jun and Nrf2 binding activity to the genomic region identified, supporting their putative involvement in CRYAB regulation following a shift in redox balance. sodium arsenite 162-168 crystallin, alpha B Mus musculus 297-302 26066304-7 2015 Pretreatment of C2C12 cells with the JNK inhibitor SP600125 induced a decrease in c-Jun and Nrf2 content and was able to counteract the NaAsO2-mediated increase in CRYAB expression. sodium arsenite 136-142 mitogen-activated protein kinase 8 Mus musculus 37-40 26066304-7 2015 Pretreatment of C2C12 cells with the JNK inhibitor SP600125 induced a decrease in c-Jun and Nrf2 content and was able to counteract the NaAsO2-mediated increase in CRYAB expression. sodium arsenite 136-142 crystallin, alpha B Mus musculus 164-169 25982963-5 2015 This inhibitory effect of NaAsO2 was attenuated by insulin. sodium arsenite 26-32 insulin Homo sapiens 51-58 25982963-6 2015 It was found that blocking PI3K or Akt by selective inhibitors canceled the protective effect of insulin against NaAsO2-induced neurite outgrowth impairment suggesting the essential role of active PI3K and Akt in insulin"s protective action. sodium arsenite 113-119 AKT serine/threonine kinase 1 Homo sapiens 35-38 25982963-6 2015 It was found that blocking PI3K or Akt by selective inhibitors canceled the protective effect of insulin against NaAsO2-induced neurite outgrowth impairment suggesting the essential role of active PI3K and Akt in insulin"s protective action. sodium arsenite 113-119 insulin Homo sapiens 97-104 25982963-6 2015 It was found that blocking PI3K or Akt by selective inhibitors canceled the protective effect of insulin against NaAsO2-induced neurite outgrowth impairment suggesting the essential role of active PI3K and Akt in insulin"s protective action. sodium arsenite 113-119 AKT serine/threonine kinase 1 Homo sapiens 206-209 25982963-6 2015 It was found that blocking PI3K or Akt by selective inhibitors canceled the protective effect of insulin against NaAsO2-induced neurite outgrowth impairment suggesting the essential role of active PI3K and Akt in insulin"s protective action. sodium arsenite 113-119 insulin Homo sapiens 213-220 25982963-8 2015 Moreover, NaAsO2 decreased the Akt activity, as it caused reduction in Akt phosphorylation, and downregulated expression of SIRT1. sodium arsenite 10-16 AKT serine/threonine kinase 1 Homo sapiens 31-34 25982963-8 2015 Moreover, NaAsO2 decreased the Akt activity, as it caused reduction in Akt phosphorylation, and downregulated expression of SIRT1. sodium arsenite 10-16 AKT serine/threonine kinase 1 Homo sapiens 71-74 25982963-8 2015 Moreover, NaAsO2 decreased the Akt activity, as it caused reduction in Akt phosphorylation, and downregulated expression of SIRT1. sodium arsenite 10-16 sirtuin 1 Homo sapiens 124-129 25982963-9 2015 Additionally, the reduction of these signals by NaAsO2 was attenuated by insulin. sodium arsenite 48-54 insulin Homo sapiens 73-80 26024302-4 2015 P19 cells were exposed to 0, 0.1, or 0.5 muM sodium arsenite and induced to form embryoid bodies over a period of 5 days. sodium arsenite 45-60 interleukin 23, alpha subunit p19 Mus musculus 0-3 24961358-5 2015 On the other hand, sodium arsenite activated pro-inflammatory signals, including beta-catenin, nuclear factor-kappaB (NF-kappaB), p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor alpha and cyclooxygenase-2 (COX-2). sodium arsenite 19-34 mitogen-activated protein kinase 14 Homo sapiens 130-166 24961358-5 2015 On the other hand, sodium arsenite activated pro-inflammatory signals, including beta-catenin, nuclear factor-kappaB (NF-kappaB), p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor alpha and cyclooxygenase-2 (COX-2). sodium arsenite 19-34 tumor necrosis factor Homo sapiens 175-202 24961358-5 2015 On the other hand, sodium arsenite activated pro-inflammatory signals, including beta-catenin, nuclear factor-kappaB (NF-kappaB), p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor alpha and cyclooxygenase-2 (COX-2). sodium arsenite 19-34 prostaglandin-endoperoxide synthase 2 Homo sapiens 207-223 24961358-5 2015 On the other hand, sodium arsenite activated pro-inflammatory signals, including beta-catenin, nuclear factor-kappaB (NF-kappaB), p38 mitogen-activated protein kinase (MAPK), tumor necrosis factor alpha and cyclooxygenase-2 (COX-2). sodium arsenite 19-34 prostaglandin-endoperoxide synthase 2 Homo sapiens 225-230 26130939-7 2015 RESULTS: NaAsO2 caused significant increases (P < 0.05) in MDA levels and MPO activity, with significant reductions (P < 0.05) in GST, GPX, CAT and SOD activities in the stomach and intestines. sodium arsenite 9-15 myeloperoxidase Rattus norvegicus 77-80 26130939-7 2015 RESULTS: NaAsO2 caused significant increases (P < 0.05) in MDA levels and MPO activity, with significant reductions (P < 0.05) in GST, GPX, CAT and SOD activities in the stomach and intestines. sodium arsenite 9-15 catalase Rattus norvegicus 146-149 26137629-5 2015 RESULTS: A marked increase in the secretion of active MMP-9 in the arsenic-treated (1.0 mumol/L NaAsO2) cells was observed in comparison to the passage-matched untreated control (0.0 mumol/L NaAsO2) cells at 28 and 35 passages. sodium arsenite 96-102 matrix metallopeptidase 9 Homo sapiens 54-59 26137629-5 2015 RESULTS: A marked increase in the secretion of active MMP-9 in the arsenic-treated (1.0 mumol/L NaAsO2) cells was observed in comparison to the passage-matched untreated control (0.0 mumol/L NaAsO2) cells at 28 and 35 passages. sodium arsenite 191-197 matrix metallopeptidase 9 Homo sapiens 54-59 25576766-5 2015 We also investigated the diabetogenic ability of splenocytes using an adoptive transfer model and the effect of SA on the proliferation, activation, and expression of glucose transporter 1 (Glut1) in splenocytes treated with SA in vitro and splenocytes isolated from SA-treated mice. sodium arsenite 112-114 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 167-188 25576766-5 2015 We also investigated the diabetogenic ability of splenocytes using an adoptive transfer model and the effect of SA on the proliferation, activation, and expression of glucose transporter 1 (Glut1) in splenocytes treated with SA in vitro and splenocytes isolated from SA-treated mice. sodium arsenite 112-114 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 190-195 25576766-5 2015 We also investigated the diabetogenic ability of splenocytes using an adoptive transfer model and the effect of SA on the proliferation, activation, and expression of glucose transporter 1 (Glut1) in splenocytes treated with SA in vitro and splenocytes isolated from SA-treated mice. sodium arsenite 225-227 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 167-188 25576766-5 2015 We also investigated the diabetogenic ability of splenocytes using an adoptive transfer model and the effect of SA on the proliferation, activation, and expression of glucose transporter 1 (Glut1) in splenocytes treated with SA in vitro and splenocytes isolated from SA-treated mice. sodium arsenite 225-227 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 190-195 25576766-5 2015 We also investigated the diabetogenic ability of splenocytes using an adoptive transfer model and the effect of SA on the proliferation, activation, and expression of glucose transporter 1 (Glut1) in splenocytes treated with SA in vitro and splenocytes isolated from SA-treated mice. sodium arsenite 225-227 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 167-188 25576766-5 2015 We also investigated the diabetogenic ability of splenocytes using an adoptive transfer model and the effect of SA on the proliferation, activation, and expression of glucose transporter 1 (Glut1) in splenocytes treated with SA in vitro and splenocytes isolated from SA-treated mice. sodium arsenite 225-227 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 190-195 25576766-8 2015 The number of total splenocytes and T cells and both the number and the proportion of CD4+ IFN-gamma+ and CD8+ IFN-gamma+ T cells in the spleen were significantly reduced in SA-treated NOD mice compared with controls. sodium arsenite 174-176 CD4 antigen Mus musculus 86-89 25576766-8 2015 The number of total splenocytes and T cells and both the number and the proportion of CD4+ IFN-gamma+ and CD8+ IFN-gamma+ T cells in the spleen were significantly reduced in SA-treated NOD mice compared with controls. sodium arsenite 174-176 interferon gamma Mus musculus 91-100 25576766-8 2015 The number of total splenocytes and T cells and both the number and the proportion of CD4+ IFN-gamma+ and CD8+ IFN-gamma+ T cells in the spleen were significantly reduced in SA-treated NOD mice compared with controls. sodium arsenite 174-176 interferon gamma Mus musculus 111-120 25576766-11 2015 In addition, the expression of Glut1 and phosphorylated ERK1/2 was decreased by SA treatment. sodium arsenite 80-82 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 31-36 25576766-11 2015 In addition, the expression of Glut1 and phosphorylated ERK1/2 was decreased by SA treatment. sodium arsenite 80-82 mitogen-activated protein kinase 3 Mus musculus 56-62 25924428-3 2015 The expression level of ERalpha mRNA and protein in lung tissue of the male and female offspring in different developmental periods and different doses (low, middle, high) of sodium arsenite exposure were detected by real-time PCR and Western blot. sodium arsenite 175-190 estrogen receptor 1 (alpha) Mus musculus 24-31 25797979-7 2015 The weight gain of SA-exposed mice was decreased compared with the controls; however, this decrease in body weight gain was prevented when the feed was supplemented with PLE. sodium arsenite 19-21 perinatal lethality Mus musculus 170-173 26339590-2 2015 The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology. sodium arsenite 51-66 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 88-93 26339590-2 2015 The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology. sodium arsenite 51-66 solute carrier family 2 (facilitated glucose transporter), member 3 Mus musculus 95-100 26339590-2 2015 The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology. sodium arsenite 51-66 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 106-111 26339590-2 2015 The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology. sodium arsenite 68-74 solute carrier family 2 (facilitated glucose transporter), member 1 Mus musculus 88-93 26339590-2 2015 The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology. sodium arsenite 68-74 solute carrier family 2 (facilitated glucose transporter), member 3 Mus musculus 95-100 26339590-2 2015 The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology. sodium arsenite 68-74 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 106-111 26160017-1 2015 BACKGROUND AND AIMS: We have previously shown that neuroglobin (Ngb) expression can be regulated by sodium arsenite (NaAsO2) exposure in rat cerebellar granule neurons (CGNs). sodium arsenite 100-115 neuroglobin Rattus norvegicus 51-62 26160017-1 2015 BACKGROUND AND AIMS: We have previously shown that neuroglobin (Ngb) expression can be regulated by sodium arsenite (NaAsO2) exposure in rat cerebellar granule neurons (CGNs). sodium arsenite 100-115 neuroglobin Rattus norvegicus 64-67 26160017-1 2015 BACKGROUND AND AIMS: We have previously shown that neuroglobin (Ngb) expression can be regulated by sodium arsenite (NaAsO2) exposure in rat cerebellar granule neurons (CGNs). sodium arsenite 117-123 neuroglobin Rattus norvegicus 51-62 26160017-1 2015 BACKGROUND AND AIMS: We have previously shown that neuroglobin (Ngb) expression can be regulated by sodium arsenite (NaAsO2) exposure in rat cerebellar granule neurons (CGNs). sodium arsenite 117-123 neuroglobin Rattus norvegicus 64-67 26160017-11 2015 RESULTS: NaAsO2 induced cytotoxicity in rat CGNs, increased GTP-bound form of Cdc42 and Rac1 GTPases in the cells. sodium arsenite 9-15 cell division cycle 42 Rattus norvegicus 78-83 26160017-11 2015 RESULTS: NaAsO2 induced cytotoxicity in rat CGNs, increased GTP-bound form of Cdc42 and Rac1 GTPases in the cells. sodium arsenite 9-15 Rac family small GTPase 1 Rattus norvegicus 88-92 26160017-12 2015 Furthermore, inhibition of Cdc42 or Rac1 activity using the inhibitor ZCL278 or NSC23766 decreased apoptosis and increased cell viability in the cells exposed to NaAsO2. sodium arsenite 162-168 cell division cycle 42 Rattus norvegicus 27-32 26160017-12 2015 Furthermore, inhibition of Cdc42 or Rac1 activity using the inhibitor ZCL278 or NSC23766 decreased apoptosis and increased cell viability in the cells exposed to NaAsO2. sodium arsenite 162-168 Rac family small GTPase 1 Rattus norvegicus 36-40 26160017-13 2015 Using siRNA-mediated knockdown, we show that NaAsO2-induced cytotoxicity was exacerbated, activation of Cdc42 (GTP-Cdc42) and Rac1 (GTP-Rac1) was increased in Ngb RNA silencing cells. sodium arsenite 45-51 cell division cycle 42 Rattus norvegicus 104-109 26160017-13 2015 Using siRNA-mediated knockdown, we show that NaAsO2-induced cytotoxicity was exacerbated, activation of Cdc42 (GTP-Cdc42) and Rac1 (GTP-Rac1) was increased in Ngb RNA silencing cells. sodium arsenite 45-51 cell division cycle 42 Rattus norvegicus 115-120 26160017-13 2015 Using siRNA-mediated knockdown, we show that NaAsO2-induced cytotoxicity was exacerbated, activation of Cdc42 (GTP-Cdc42) and Rac1 (GTP-Rac1) was increased in Ngb RNA silencing cells. sodium arsenite 45-51 Rac family small GTPase 1 Rattus norvegicus 126-130 26160017-13 2015 Using siRNA-mediated knockdown, we show that NaAsO2-induced cytotoxicity was exacerbated, activation of Cdc42 (GTP-Cdc42) and Rac1 (GTP-Rac1) was increased in Ngb RNA silencing cells. sodium arsenite 45-51 Rac family small GTPase 1 Rattus norvegicus 132-140 26160017-13 2015 Using siRNA-mediated knockdown, we show that NaAsO2-induced cytotoxicity was exacerbated, activation of Cdc42 (GTP-Cdc42) and Rac1 (GTP-Rac1) was increased in Ngb RNA silencing cells. sodium arsenite 45-51 neuroglobin Rattus norvegicus 159-162 26160017-14 2015 CONCLUSIONS: cytotoxic effects of NaAsO2 on rat CGNs is induced at least partly by Cdc42 and Rac1 activation, and Ngb can inhibit Cdc42 and Rac1 activation to play protective role in rat CGNs exposed to NaAsO2. sodium arsenite 34-40 cell division cycle 42 Rattus norvegicus 83-88 26160017-14 2015 CONCLUSIONS: cytotoxic effects of NaAsO2 on rat CGNs is induced at least partly by Cdc42 and Rac1 activation, and Ngb can inhibit Cdc42 and Rac1 activation to play protective role in rat CGNs exposed to NaAsO2. sodium arsenite 34-40 Rac family small GTPase 1 Rattus norvegicus 93-97 26160017-14 2015 CONCLUSIONS: cytotoxic effects of NaAsO2 on rat CGNs is induced at least partly by Cdc42 and Rac1 activation, and Ngb can inhibit Cdc42 and Rac1 activation to play protective role in rat CGNs exposed to NaAsO2. sodium arsenite 34-40 Rac family small GTPase 1 Rattus norvegicus 140-144 26160017-14 2015 CONCLUSIONS: cytotoxic effects of NaAsO2 on rat CGNs is induced at least partly by Cdc42 and Rac1 activation, and Ngb can inhibit Cdc42 and Rac1 activation to play protective role in rat CGNs exposed to NaAsO2. sodium arsenite 203-209 neuroglobin Rattus norvegicus 114-117 25821630-0 2015 Inhibitory effects of sodium arsenite and acacia honey on acetylcholinesterase in rats. sodium arsenite 22-37 acetylcholinesterase Rattus norvegicus 58-78 25821630-1 2015 This study was conducted to investigate the effect of sodium arsenite and Acacia honey on acetylcholinesterase (AChE) activity and electrolytes in the brain and serum of Wistar rats. sodium arsenite 54-69 acetylcholinesterase Rattus norvegicus 90-110 25821630-1 2015 This study was conducted to investigate the effect of sodium arsenite and Acacia honey on acetylcholinesterase (AChE) activity and electrolytes in the brain and serum of Wistar rats. sodium arsenite 54-69 acetylcholinesterase Rattus norvegicus 112-116 25821630-3 2015 The sodium arsenite and Acacia honey significantly (P < 0.05) decreased AChE activity in the brain with the combined treatment being more potent. sodium arsenite 4-19 acetylcholinesterase Rattus norvegicus 75-79 25821630-4 2015 Furthermore, sodium arsenite and Acacia honey significantly (P < 0.05) decreased AChE activity in the serum. sodium arsenite 13-28 acetylcholinesterase Rattus norvegicus 84-88 25821630-7 2015 These findings suggest that sodium arsenite and/or Acacia honey modulates acetylcholinesterase activities which may be explored in the management of Alzheimer"s diseases but this might be counteracted by the hepatotoxicity induced by arsenics. sodium arsenite 28-43 acetylcholinesterase Rattus norvegicus 74-94 25105348-5 2015 From the results, co-administration of Acacia honey with sodium arsenite on the animals increased (P < 0.05) glutathione peroxidase, superoxide dismutase and catalase activities with concomitant decrease in malondialdehyde levels and anti-clastogenic effects relative to the group treated with sodium arsenite only. sodium arsenite 57-72 catalase Rattus norvegicus 161-169 25241256-8 2014 Furthermore, we show that NaAsO2 treatment led to a dramatic decrease of the expression level of LMP1 and the cellular protein PML. sodium arsenite 26-32 PDZ and LIM domain 7 Homo sapiens 97-101 25241256-8 2014 Furthermore, we show that NaAsO2 treatment led to a dramatic decrease of the expression level of LMP1 and the cellular protein PML. sodium arsenite 26-32 PML nuclear body scaffold Homo sapiens 127-130 25412313-2 2014 Our present study, for the first time to the best of our knowledge, revealed a potential role of p27 in inhibiting S6-mediated hypoxia-inducible factor-1alpha (HIF-1alpha) protein translation, which contributed to the protection from environmental carcinogen (sodium arsenite)-induced cell transformation. sodium arsenite 260-275 interferon alpha inducible protein 27 Homo sapiens 97-100 25412313-2 2014 Our present study, for the first time to the best of our knowledge, revealed a potential role of p27 in inhibiting S6-mediated hypoxia-inducible factor-1alpha (HIF-1alpha) protein translation, which contributed to the protection from environmental carcinogen (sodium arsenite)-induced cell transformation. sodium arsenite 260-275 hypoxia inducible factor 1 subunit alpha Homo sapiens 160-170 25301106-8 2014 Thus, sodium arsenite may confer its cytotoxic effect partly through the aberrant activation of CDKs and the resultant perturbation of cell cycle progression. sodium arsenite 6-21 cyclin dependent kinase 1 Homo sapiens 96-100 25271956-6 2014 In a series of more than 30 normal donors, two individuals were found to be sensitive to low concentration (10 nM equivalent ~ 1 ppb drinking water exposure) to sodium arsenite-induced inhibition of T cell proliferation produced by phytohemagglutinin (PHA) and anti-CD3/anti-CD28. sodium arsenite 161-176 CD28 molecule Homo sapiens 275-279 24570342-0 2014 Long-term low-dose exposure of human urothelial cells to sodium arsenite activates lipocalin-2 via promoter hypomethylation. sodium arsenite 57-72 lipocalin 2 Homo sapiens 83-94 24865968-3 2014 Exposure of HCT116 colon cancer cells to sodium arsenite stimulated checkpoint kinase 2 (Chk2)- and mitogen-activated protein kinase p38 (p38(MAPK))-mediated phosphorylation of HuR at positions S88 and T118. sodium arsenite 41-56 checkpoint kinase 2 Homo sapiens 68-87 24865968-3 2014 Exposure of HCT116 colon cancer cells to sodium arsenite stimulated checkpoint kinase 2 (Chk2)- and mitogen-activated protein kinase p38 (p38(MAPK))-mediated phosphorylation of HuR at positions S88 and T118. sodium arsenite 41-56 checkpoint kinase 2 Homo sapiens 89-93 24865968-3 2014 Exposure of HCT116 colon cancer cells to sodium arsenite stimulated checkpoint kinase 2 (Chk2)- and mitogen-activated protein kinase p38 (p38(MAPK))-mediated phosphorylation of HuR at positions S88 and T118. sodium arsenite 41-56 mitogen-activated protein kinase 14 Homo sapiens 133-136 24865968-3 2014 Exposure of HCT116 colon cancer cells to sodium arsenite stimulated checkpoint kinase 2 (Chk2)- and mitogen-activated protein kinase p38 (p38(MAPK))-mediated phosphorylation of HuR at positions S88 and T118. sodium arsenite 41-56 mitogen-activated protein kinase 14 Homo sapiens 138-141 24865968-3 2014 Exposure of HCT116 colon cancer cells to sodium arsenite stimulated checkpoint kinase 2 (Chk2)- and mitogen-activated protein kinase p38 (p38(MAPK))-mediated phosphorylation of HuR at positions S88 and T118. sodium arsenite 41-56 ELAV like RNA binding protein 1 Homo sapiens 177-180 25344162-9 2014 We found that the protein expression levels of Nrf2 were increased in both NaAsO2- and As2O3-treated cells. sodium arsenite 75-81 NFE2 like bZIP transcription factor 2 Homo sapiens 47-51 23690446-2 2014 In two experiments, we examined the urothelial proliferative effects of treatment with 173 ppm sodium arsenite (100 ppm arsenic) in the drinking water for 6 and 24 hr, and 3, 7, and 14 days in female F344 rats and 43.3 ppm sodium arsenite (25 ppm arsenic) in female C57BL/6 wild-type and arsenic (+3 oxidation state) methyltransferase knockout (As3mt KO) mice that are unable to methylate arsenicals. sodium arsenite 95-110 arsenite methyltransferase Rattus norvegicus 266-334 24519527-3 2014 We recently demonstrated that a combination of sodium arsenite (NaAsO2) and hyperthermia sensitizes p53-expressing ovarian cancer cells to cisplatin by modulating DNA repair pathway and enhancing platinum accumulation. sodium arsenite 47-62 tumor protein p53 Homo sapiens 100-103 24519527-3 2014 We recently demonstrated that a combination of sodium arsenite (NaAsO2) and hyperthermia sensitizes p53-expressing ovarian cancer cells to cisplatin by modulating DNA repair pathway and enhancing platinum accumulation. sodium arsenite 64-70 tumor protein p53 Homo sapiens 100-103 24519527-7 2014 Western blot analysis of cyclin A and cyclin B suggested that combined NaAsO2, hyperthermia, and cisplatin induced mitotic arrest. sodium arsenite 71-77 cyclin A2 Homo sapiens 25-33 24412756-5 2014 Dephosphorylated AMPKalpha phosphorylates heat shock factor 1 (HSF1) at Ser303, leading to significant transcriptional suppression of HSP70 and HSP27 in CdCl2- or NaAsO2-treated cells. sodium arsenite 163-169 heat shock transcription factor 1 Homo sapiens 42-61 24412756-5 2014 Dephosphorylated AMPKalpha phosphorylates heat shock factor 1 (HSF1) at Ser303, leading to significant transcriptional suppression of HSP70 and HSP27 in CdCl2- or NaAsO2-treated cells. sodium arsenite 163-169 heat shock transcription factor 1 Homo sapiens 63-67 24412756-5 2014 Dephosphorylated AMPKalpha phosphorylates heat shock factor 1 (HSF1) at Ser303, leading to significant transcriptional suppression of HSP70 and HSP27 in CdCl2- or NaAsO2-treated cells. sodium arsenite 163-169 heat shock protein family A (Hsp70) member 4 Homo sapiens 134-139 24412756-5 2014 Dephosphorylated AMPKalpha phosphorylates heat shock factor 1 (HSF1) at Ser303, leading to significant transcriptional suppression of HSP70 and HSP27 in CdCl2- or NaAsO2-treated cells. sodium arsenite 163-169 heat shock protein family B (small) member 1 Homo sapiens 144-149 24357338-0 2014 p38 and extracellular signal-regulated kinases activations have opposite effects on primary-cultured rat cerebellar granule neurons exposed to sodium arsenite. sodium arsenite 143-158 mitogen activated protein kinase 14 Rattus norvegicus 0-3 24585092-9 2014 Importantly, their protective effects against insults from both sodium arsenite and H2O2 were Nrf2-dependent. sodium arsenite 64-79 NFE2 like bZIP transcription factor 2 Homo sapiens 94-98 24379400-1 2014 Activating transcription factor 5 (ATF5) is a stress-response transcription factor that responds to amino acid limitation and exposure to cadmium chloride (CdCl2) and sodium arsenite (NaAsO2). sodium arsenite 167-182 activating transcription factor 5 Homo sapiens 0-33 24379400-1 2014 Activating transcription factor 5 (ATF5) is a stress-response transcription factor that responds to amino acid limitation and exposure to cadmium chloride (CdCl2) and sodium arsenite (NaAsO2). sodium arsenite 167-182 activating transcription factor 5 Homo sapiens 35-39 24379400-1 2014 Activating transcription factor 5 (ATF5) is a stress-response transcription factor that responds to amino acid limitation and exposure to cadmium chloride (CdCl2) and sodium arsenite (NaAsO2). sodium arsenite 184-190 activating transcription factor 5 Homo sapiens 0-33 24379400-1 2014 Activating transcription factor 5 (ATF5) is a stress-response transcription factor that responds to amino acid limitation and exposure to cadmium chloride (CdCl2) and sodium arsenite (NaAsO2). sodium arsenite 184-190 activating transcription factor 5 Homo sapiens 35-39 24379400-2 2014 The N-terminal amino acids contribute to the destabilization of the ATF5 protein in steady-state conditions and serve as a stabilization domain in the stress response after CdCl2 or NaAsO2 exposure. sodium arsenite 182-188 activating transcription factor 5 Homo sapiens 68-72 24284797-4 2014 Treatment of a human colon cancer cell line (HCT116) with 100 muM sodium arsenite increased SRSF3-PTC mRNA levels without changing SRSF3-FL mRNA levels. sodium arsenite 66-81 serine and arginine rich splicing factor 3 Homo sapiens 92-97 24100277-4 2014 The apoptosis induced by sodium meta-arsenite was associated with cleavage of caspases 3, 8, and 9, and poly (ADP-ribose) polymerase (PARP) and increased annexin V-positive cells, and was inhibited by the pan-caspase inhibitor Z-VAD-fmk. sodium arsenite 25-45 poly(ADP-ribose) polymerase 1 Homo sapiens 78-132 24100277-4 2014 The apoptosis induced by sodium meta-arsenite was associated with cleavage of caspases 3, 8, and 9, and poly (ADP-ribose) polymerase (PARP) and increased annexin V-positive cells, and was inhibited by the pan-caspase inhibitor Z-VAD-fmk. sodium arsenite 25-45 poly(ADP-ribose) polymerase 1 Homo sapiens 134-138 24100277-7 2014 Moreover, sodium meta-arsenite led to the accumulation of intracellular reactive oxygen species (ROS) and N-acetyl-L-cysteine (NAC), a ROS scavenger, decreased sodium meta-arsenite-induced levels of cleaved PARP and LC3-II. sodium arsenite 10-30 X-linked Kx blood group Homo sapiens 127-130 24100277-7 2014 Moreover, sodium meta-arsenite led to the accumulation of intracellular reactive oxygen species (ROS) and N-acetyl-L-cysteine (NAC), a ROS scavenger, decreased sodium meta-arsenite-induced levels of cleaved PARP and LC3-II. sodium arsenite 10-30 poly(ADP-ribose) polymerase 1 Homo sapiens 207-211 24100277-7 2014 Moreover, sodium meta-arsenite led to the accumulation of intracellular reactive oxygen species (ROS) and N-acetyl-L-cysteine (NAC), a ROS scavenger, decreased sodium meta-arsenite-induced levels of cleaved PARP and LC3-II. sodium arsenite 160-180 X-linked Kx blood group Homo sapiens 127-130 24100277-7 2014 Moreover, sodium meta-arsenite led to the accumulation of intracellular reactive oxygen species (ROS) and N-acetyl-L-cysteine (NAC), a ROS scavenger, decreased sodium meta-arsenite-induced levels of cleaved PARP and LC3-II. sodium arsenite 160-180 poly(ADP-ribose) polymerase 1 Homo sapiens 207-211 24100277-8 2014 Propidium iodide (PI) staining also showed that NAC restored membrane integrity, damaged by sodium meta-arsenite. sodium arsenite 92-112 X-linked Kx blood group Homo sapiens 48-51 25087952-0 2014 Hyper-O-GlcNAcylation inhibits the induction of heat shock protein 70 (Hsp 70) by sodium arsenite in HeLa cells. sodium arsenite 82-97 heat shock protein family A (Hsp70) member 4 Homo sapiens 48-69 25087952-0 2014 Hyper-O-GlcNAcylation inhibits the induction of heat shock protein 70 (Hsp 70) by sodium arsenite in HeLa cells. sodium arsenite 82-97 heat shock protein family A (Hsp70) member 4 Homo sapiens 71-77 25610880-9 2014 The mRNA expressions of genes for gluconeogenesis-related enzymes, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK) were significantly reduced in the liver of SA-treated diabetic db/db mice. sodium arsenite 188-190 glucose-6-phosphatase, catalytic Mus musculus 67-88 25610880-9 2014 The mRNA expressions of genes for gluconeogenesis-related enzymes, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK) were significantly reduced in the liver of SA-treated diabetic db/db mice. sodium arsenite 188-190 glucose-6-phosphatase, catalytic Mus musculus 90-96 25610880-9 2014 The mRNA expressions of genes for gluconeogenesis-related enzymes, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK) were significantly reduced in the liver of SA-treated diabetic db/db mice. sodium arsenite 188-190 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus 103-136 25610880-9 2014 The mRNA expressions of genes for gluconeogenesis-related enzymes, glucose 6-phosphatase (G6Pase), and phosphoenolpyruvate carboxykinase (PEPCK) were significantly reduced in the liver of SA-treated diabetic db/db mice. sodium arsenite 188-190 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus 138-143 25610880-10 2014 In primary hepatocytes, SA treatment decreased glucose production and the expression of G6Pase, PEPCK, and hepatocyte nuclear factor 4 alpha (HNF-4alpha) mRNA. sodium arsenite 24-26 glucose-6-phosphatase, catalytic Mus musculus 88-94 25610880-10 2014 In primary hepatocytes, SA treatment decreased glucose production and the expression of G6Pase, PEPCK, and hepatocyte nuclear factor 4 alpha (HNF-4alpha) mRNA. sodium arsenite 24-26 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus 96-101 25610880-10 2014 In primary hepatocytes, SA treatment decreased glucose production and the expression of G6Pase, PEPCK, and hepatocyte nuclear factor 4 alpha (HNF-4alpha) mRNA. sodium arsenite 24-26 hepatic nuclear factor 4, alpha Mus musculus 107-140 25610880-10 2014 In primary hepatocytes, SA treatment decreased glucose production and the expression of G6Pase, PEPCK, and hepatocyte nuclear factor 4 alpha (HNF-4alpha) mRNA. sodium arsenite 24-26 hepatic nuclear factor 4, alpha Mus musculus 142-152 25610880-11 2014 Small heterodimer partner (SHP) mRNA expression was increased in hepatocytes dependent upon the SA concentration. sodium arsenite 96-98 nuclear receptor subfamily 0, group B, member 2 Mus musculus 0-25 25610880-11 2014 Small heterodimer partner (SHP) mRNA expression was increased in hepatocytes dependent upon the SA concentration. sodium arsenite 96-98 nuclear receptor subfamily 0, group B, member 2 Mus musculus 27-30 25610880-12 2014 The expression of Sirt1 mRNA and protein was reduced, and acetylated forkhead box protein O1 (FoxO1) was induced by SA treatment in hepatocytes. sodium arsenite 116-118 forkhead box O1 Mus musculus 69-92 25610880-12 2014 The expression of Sirt1 mRNA and protein was reduced, and acetylated forkhead box protein O1 (FoxO1) was induced by SA treatment in hepatocytes. sodium arsenite 116-118 forkhead box O1 Mus musculus 94-99 25610880-14 2014 Oral intubation of SA ameliorates hyperglycemia in db/db mice by reducing hepatic gluconeogenesis through the decrease of Sirt1 expression and increase in acetylated FoxO1. sodium arsenite 19-21 sirtuin 1 Mus musculus 122-127 25610880-14 2014 Oral intubation of SA ameliorates hyperglycemia in db/db mice by reducing hepatic gluconeogenesis through the decrease of Sirt1 expression and increase in acetylated FoxO1. sodium arsenite 19-21 forkhead box O1 Mus musculus 166-171 24391030-3 2013 Compared to that in the control cells, the survival rate of ARG1 gene-overexpressing cells was much higher following exposure to lower sodium arsenite (<= 8 microM). sodium arsenite 135-150 arginase 1 Homo sapiens 60-64 24391030-4 2013 When cells were exposed to lower sodium arsenite for 24 h, the arsenite content of ARG1 gene-overexpressing cells decreased and arsenic efflux increased. sodium arsenite 33-48 arginase 1 Homo sapiens 83-87 24145059-3 2013 We examined changes in the mRNA level of the lectin-like oxidized LDL (oxLDL) receptor (LOX-1) in a mouse aortic endothelial cell line, END-D, after sodium arsenite (SA) treatment. sodium arsenite 149-164 oxidized low density lipoprotein (lectin-like) receptor 1 Mus musculus 88-93 24145059-3 2013 We examined changes in the mRNA level of the lectin-like oxidized LDL (oxLDL) receptor (LOX-1) in a mouse aortic endothelial cell line, END-D, after sodium arsenite (SA) treatment. sodium arsenite 166-168 oxidized low density lipoprotein (lectin-like) receptor 1 Mus musculus 88-93 24145059-4 2013 SA treatment significantly upregulated LOX-1 mRNA expression; this finding was also verified at the protein expression level. sodium arsenite 0-2 oxidized low density lipoprotein (lectin-like) receptor 1 Mus musculus 39-44 24145059-7 2013 We observed that SA increased the levels of the phosphorylated forms of nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-kappaB)/p65. sodium arsenite 17-19 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 140-149 24145059-7 2013 We observed that SA increased the levels of the phosphorylated forms of nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-kappaB)/p65. sodium arsenite 17-19 v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus 151-154 24145059-8 2013 SA-induced upregulation of LOX-1 protein expression was clearly prevented by treatment with an antioxidant, N-acetylcysteine (NAC), or an NF-kappaB inhibitor, caffeic acid phenethylester (CAPE). sodium arsenite 0-2 oxidized low density lipoprotein (lectin-like) receptor 1 Mus musculus 27-32 24145059-8 2013 SA-induced upregulation of LOX-1 protein expression was clearly prevented by treatment with an antioxidant, N-acetylcysteine (NAC), or an NF-kappaB inhibitor, caffeic acid phenethylester (CAPE). sodium arsenite 0-2 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 138-147 24057451-3 2013 In this study, we investigated the toxic effects of sodium arsenite (NaAsO2) on primary cultured rat cerebellar granule neurons (CGNs) and detected neuroglobin (Ngb) expression in rat CGNs exposed to NaAsO2. sodium arsenite 200-206 neuroglobin Rattus norvegicus 148-159 24057451-4 2013 Our results show that apoptosis was obviously induced by NaAsO2 treatment in rat CGNs by annexin V-fluorescein isothiocyanate assay. sodium arsenite 57-63 annexin A5 Rattus norvegicus 89-98 24057451-6 2013 Ngb protein and mRNA expression were significantly downregulated in rat CGNs shortly after NaAsO2 exposure and then upregulated after a longer time of exposure. sodium arsenite 91-97 neuroglobin Rattus norvegicus 0-3 24057451-7 2013 Furthermore, mRNA expression changed more than protein expression and the toxic effect of NaAsO2 on Ngb expression is dose dependent. sodium arsenite 90-96 neuroglobin Rattus norvegicus 100-103 24057451-8 2013 Higher Ngb expression was also detected in rat cerebellum, but not in other parts (cerebrum, hippocampus, and midbrain) of the brain exposed to NaAsO2 for 16 weeks. sodium arsenite 144-150 neuroglobin Rattus norvegicus 7-10 24057451-9 2013 Taken together, cytotoxic effects of NaAsO2 on rat CGNs is induced at least partly by oxidative stress and Ngb may influence the course of arsenic toxicity in rat CGNs and rat cerebellum. sodium arsenite 37-43 neuroglobin Rattus norvegicus 107-110 24004876-3 2013 Our results demonstrated that both NaAsO2 and As2O3 caused oxidative stress, genotoxicity, cytotoxicity, cell cycle arrest as well as apoptosis, while As2O3 induced higher production of reactive oxygen species (ROS) with a more remarkable decrease in superoxide dismutase (SOD) activities and intracellular levels of glutathione (GSH) than NaAsO2. sodium arsenite 35-41 superoxide dismutase 1 Homo sapiens 251-271 24004876-3 2013 Our results demonstrated that both NaAsO2 and As2O3 caused oxidative stress, genotoxicity, cytotoxicity, cell cycle arrest as well as apoptosis, while As2O3 induced higher production of reactive oxygen species (ROS) with a more remarkable decrease in superoxide dismutase (SOD) activities and intracellular levels of glutathione (GSH) than NaAsO2. sodium arsenite 35-41 superoxide dismutase 1 Homo sapiens 273-276 23361474-7 2013 RESULTS: In response to sodium arsenite, colon cancer cells (HCT116) increased levels of TRA2beta1 mRNA encoding a functional, full-length Tra2beta with a peak around 6 h without changing its mRNA stability. sodium arsenite 24-39 transformer 2 beta homolog Homo sapiens 139-147 24113175-3 2013 Blocking DR6 with antagonist antibody 5D10 promotes motor neuron survival in vitro via activation of Akt phosphorylation and inhibition of the caspase 3 signaling pathway, after growth factor withdrawal, sodium arsenite treatment or co-culture with SOD1(G93A) astrocytes. sodium arsenite 204-219 tumor necrosis factor receptor superfamily, member 21 Mus musculus 9-12 23968725-3 2013 In this study, several important angiogenesis related factors, including cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1alpha (HIF-1alpha), were up-regulated and PI3K/AKT and MAPK signal pathways were activated in human uroepithelial cell line (SV-HUC-1) treated with NaAsO2 (0, 1, 2, 4, 8 or 10muM) for 24h. sodium arsenite 319-325 hypoxia inducible factor 1 subunit alpha Homo sapiens 145-176 23968725-3 2013 In this study, several important angiogenesis related factors, including cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1alpha (HIF-1alpha), were up-regulated and PI3K/AKT and MAPK signal pathways were activated in human uroepithelial cell line (SV-HUC-1) treated with NaAsO2 (0, 1, 2, 4, 8 or 10muM) for 24h. sodium arsenite 319-325 hypoxia inducible factor 1 subunit alpha Homo sapiens 178-188 23824679-1 2013 In the present study, the role of heme oxygenase (HO)-1 in sodium arsenite (arsenite)-induced neurotoxicity was investigated using primary cultured cortical neurons. sodium arsenite 59-74 heme oxygenase 1 Homo sapiens 34-55 24174825-5 2013 The study showed that sodium arsenite significantly (P < 0.05) induced the formation of micronucleated polychromatic erythrocytes and the activities of ALP and GGT when compared with control. sodium arsenite 22-37 gamma-glutamyltransferase 1 Rattus norvegicus 163-166 23919948-0 2013 Enhanced HSP30 and HSP70 accumulation in Xenopus cells subjected to concurrent sodium arsenite and cadmium chloride stress. sodium arsenite 79-94 heat shock protein 30E L homeolog Xenopus laevis 9-14 23919948-0 2013 Enhanced HSP30 and HSP70 accumulation in Xenopus cells subjected to concurrent sodium arsenite and cadmium chloride stress. sodium arsenite 79-94 heat shock 70kDa protein L homeolog Xenopus laevis 19-24 23919948-2 2013 The present study examined the effect of simultaneous sodium arsenite and cadmium chloride treatment on the pattern of HSP30 and HSP70 accumulation in A6 kidney epithelial cells of the frog, Xenopus laevis. sodium arsenite 54-69 heat shock protein 30E L homeolog Xenopus laevis 119-124 23919948-8 2013 The addition of a mild heat shock further enhanced the accumulation of HSP30 and HSP70 in response to relatively low concentrations of sodium arsenite plus cadmium chloride. sodium arsenite 135-150 heat shock protein 30E L homeolog Xenopus laevis 71-76 23919948-8 2013 The addition of a mild heat shock further enhanced the accumulation of HSP30 and HSP70 in response to relatively low concentrations of sodium arsenite plus cadmium chloride. sodium arsenite 135-150 heat shock 70kDa protein L homeolog Xenopus laevis 81-86 24351558-1 2013 OBJECTIVE: To observe the chronic combined effects of sodium fluoride and sodium arsenite on the Runx2 and downstream related factors of bone metabolism in SD rats. sodium arsenite 74-89 RUNX family transcription factor 2 Rattus norvegicus 97-102 23603382-7 2013 The mRNA levels of SOD1, CAT, GPx and Txnrd1 were increased significantly (P<0.05) in the combined Na2SeO3+NaAsO2 treatment group. sodium arsenite 110-116 superoxide dismutase 1 Rattus norvegicus 19-23 23603382-7 2013 The mRNA levels of SOD1, CAT, GPx and Txnrd1 were increased significantly (P<0.05) in the combined Na2SeO3+NaAsO2 treatment group. sodium arsenite 110-116 catalase Rattus norvegicus 25-28 23603382-7 2013 The mRNA levels of SOD1, CAT, GPx and Txnrd1 were increased significantly (P<0.05) in the combined Na2SeO3+NaAsO2 treatment group. sodium arsenite 110-116 thioredoxin reductase 1 Rattus norvegicus 38-44 23603382-8 2013 The expressions of HSP70 and HO-1 were significantly (P<0.05) increased in the NaAsO2 group and reduced in the combined treatment group. sodium arsenite 82-88 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 19-24 23603382-8 2013 The expressions of HSP70 and HO-1 were significantly (P<0.05) increased in the NaAsO2 group and reduced in the combined treatment group. sodium arsenite 82-88 heme oxygenase 1 Rattus norvegicus 29-33 23708403-7 2013 Treatment of assay cells ectopically overexpressing the human heat-shock protein 70 (Hsp70) with 15muM sodium arsenite resulted in an additional ~4.5-fold induction of retrotransposition compared with normal assay cells, whereas treatment with 20muM produced a massive cell death. sodium arsenite 103-118 heat shock protein family A (Hsp70) member 4 Homo sapiens 62-83 23708403-7 2013 Treatment of assay cells ectopically overexpressing the human heat-shock protein 70 (Hsp70) with 15muM sodium arsenite resulted in an additional ~4.5-fold induction of retrotransposition compared with normal assay cells, whereas treatment with 20muM produced a massive cell death. sodium arsenite 103-118 heat shock protein family A (Hsp70) member 4 Homo sapiens 85-90 21809430-0 2013 Sodium arsenite induced reactive oxygen species generation, nuclear factor (erythroid-2 related) factor 2 activation, heme oxygenase-1 expression, and glutathione elevation in Chang human hepatocytes. sodium arsenite 0-15 heme oxygenase 1 Homo sapiens 118-134 21809430-3 2013 This study was conducted to evaluate the hepato-cellular Nrf2 and Nrf2-regulated antioxidant reactions of sodium arsenite exposure in Chang human hepatocytes. sodium arsenite 106-121 NFE2 like bZIP transcription factor 2 Homo sapiens 57-61 21809430-3 2013 This study was conducted to evaluate the hepato-cellular Nrf2 and Nrf2-regulated antioxidant reactions of sodium arsenite exposure in Chang human hepatocytes. sodium arsenite 106-121 NFE2 like bZIP transcription factor 2 Homo sapiens 66-70 23694735-5 2013 Immunoblot analysis of AMPA receptor subunit expression showed that the protein level of GluA1, a specific subunit of the AMPA receptor, was significantly decreased by 1 muM and 2 muM NaAsO2. sodium arsenite 184-190 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 89-94 23694735-8 2013 These results suggest that the NaAsO2 concentration inducing neurite suppression is lower than the concentration that induces cell death and is the same as the concentration that suppresses GluA1 expression. sodium arsenite 31-37 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 190-195 23694735-9 2013 Consequently, the suppression of GluA1 expression by NaAsO2 seems at least partly responsible for neurite suppression induced by NaAsO2. sodium arsenite 53-59 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 33-38 23694735-9 2013 Consequently, the suppression of GluA1 expression by NaAsO2 seems at least partly responsible for neurite suppression induced by NaAsO2. sodium arsenite 129-135 glutamate receptor, ionotropic, AMPA1 (alpha 1) Mus musculus 33-38 23900237-6 2013 The GGT and ALP activities were elevated more than fourfold, in the liver of rats treated with sodium arsenite, while it was reduced almost to half when the sodium arsenit-treated rats were fed fresh V. amgdalina leave extracts The phytochemical constituents of V. amygdalina assayed in this study may be responsible for high radical scavenging of the DPPH free radical observed. sodium arsenite 95-110 gamma-glutamyltransferase 1 Rattus norvegicus 4-7 23603059-4 2013 In addition, western blot analysis revealed that SA enhances the phosphorylations of c-Jun N-terminal kinases (JNK) and activated protein 1 (AP-1). sodium arsenite 49-51 mitogen-activated protein kinase 8 Mus musculus 111-114 23603059-6 2013 Finally, SA-induced AT1R expression was found to be prevented both by NAC and specific JNK inhibitor, SP6001325, strongly indicating that AT1R upregulation is a result of the ROS-mediated activation of the JNK signaling pathway. sodium arsenite 9-11 angiotensin II, type I receptor-associated protein Mus musculus 20-24 23603059-6 2013 Finally, SA-induced AT1R expression was found to be prevented both by NAC and specific JNK inhibitor, SP6001325, strongly indicating that AT1R upregulation is a result of the ROS-mediated activation of the JNK signaling pathway. sodium arsenite 9-11 mitogen-activated protein kinase 8 Mus musculus 87-90 23603059-6 2013 Finally, SA-induced AT1R expression was found to be prevented both by NAC and specific JNK inhibitor, SP6001325, strongly indicating that AT1R upregulation is a result of the ROS-mediated activation of the JNK signaling pathway. sodium arsenite 9-11 angiotensin II, type I receptor-associated protein Mus musculus 138-142 23603059-6 2013 Finally, SA-induced AT1R expression was found to be prevented both by NAC and specific JNK inhibitor, SP6001325, strongly indicating that AT1R upregulation is a result of the ROS-mediated activation of the JNK signaling pathway. sodium arsenite 9-11 mitogen-activated protein kinase 8 Mus musculus 206-209 23591579-4 2013 In this study, ATF2 expression was measured in NaAsO(2)-treated human uroepithelial cell line (SV-HUC-1) with 1, 2, 4, 8 and 10 muM concentrations in order to provide some basis data for the study on mechanism of bladder cancer induced by arsenic. sodium arsenite 47-55 activating transcription factor 2 Homo sapiens 15-19 23591579-4 2013 In this study, ATF2 expression was measured in NaAsO(2)-treated human uroepithelial cell line (SV-HUC-1) with 1, 2, 4, 8 and 10 muM concentrations in order to provide some basis data for the study on mechanism of bladder cancer induced by arsenic. sodium arsenite 47-55 latexin Homo sapiens 128-131 23472850-7 2013 In this study, we demonstrate that ngfb mRNA is positively modulated in mouse livers after oxidative injury via intraperitoneal injection of 14 mg/kg sodium arsenite, 6 mmol/kg L-buthionine-S-R-sulfoximine (BSO), or 300 mg/kg acetaminophen (APAP). sodium arsenite 150-165 nerve growth factor Mus musculus 35-39 23219847-6 2013 Mitochondrial damage and cytochrome-c release induced by sodium arsenite exposure was followed by initiation of the mitochondrial apoptotic pathway in NSC. sodium arsenite 57-72 cytochrome c, somatic Homo sapiens 25-37 23219847-9 2013 Overactivation of JNK1 and ERK1/2 and down-regulation of PI3K-AKT activity induced by sodium arsenite were critical factors that strongly affected neuronal differentiation. sodium arsenite 86-101 mitogen-activated protein kinase 8 Homo sapiens 18-22 23219847-11 2013 Sodium arsenite also negatively affects neuronal differentiation of NSC through overactivation of MEK-ERK and suppression of PI3K-AKT. sodium arsenite 0-15 mitogen-activated protein kinase kinase 7 Homo sapiens 98-101 23219847-11 2013 Sodium arsenite also negatively affects neuronal differentiation of NSC through overactivation of MEK-ERK and suppression of PI3K-AKT. sodium arsenite 0-15 mitogen-activated protein kinase 1 Homo sapiens 102-105 23376440-0 2013 Sodium arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through MAPK pathway activation and reactive oxygen species induction. sodium arsenite 0-15 prostaglandin-endoperoxide synthase 2 Homo sapiens 24-40 23555279-3 2013 Activation of SKN-1, either by acute pharmacological treatment with the mitochondrial toxin sodium arsenite or by mutations that cause constitutive SKN-1 activation, results in defects in neuromuscular function. sodium arsenite 92-107 BZIP domain-containing protein;Protein skinhead-1 Caenorhabditis elegans 14-19 23283970-9 2013 Sodium arsenite, an agent that induces oxidative stress, promoted nuclear export of ectopically expressed Nurr1 in HEK293T cells, and the antioxidant N-acetylcysteine rescued from this effect. sodium arsenite 0-15 nuclear receptor subfamily 4 group A member 2 Homo sapiens 106-111 23143138-0 2013 Sodium arsenite exposure inhibits AKT and Stat3 activation, suppresses self-renewal and induces apoptotic death of embryonic stem cells. sodium arsenite 0-15 thymoma viral proto-oncogene 1 Mus musculus 34-37 23143138-0 2013 Sodium arsenite exposure inhibits AKT and Stat3 activation, suppresses self-renewal and induces apoptotic death of embryonic stem cells. sodium arsenite 0-15 signal transducer and activator of transcription 3 Mus musculus 42-47 23143138-4 2013 We demonstrated that the crucial signaling pathway, which was substantially suppressed by sodium arsenite exposure (4 muM) in ESC, was the PI3K-AKT pathway linked with numerous downstream targets that control cell survival and apoptosis. sodium arsenite 90-105 thymoma viral proto-oncogene 1 Mus musculus 144-147 23143138-5 2013 Furthermore, the whole core transcription factor circuitry that control self-renewal of mouse ESC (Stat3-P-Tyr705, Oct4, Sox2 and Nanog) was strongly down-regulated by sodium arsenite (4 muM) exposure. sodium arsenite 168-183 signal transducer and activator of transcription 3 Mus musculus 99-104 23143138-5 2013 Furthermore, the whole core transcription factor circuitry that control self-renewal of mouse ESC (Stat3-P-Tyr705, Oct4, Sox2 and Nanog) was strongly down-regulated by sodium arsenite (4 muM) exposure. sodium arsenite 168-183 POU domain, class 5, transcription factor 1, related sequence 1 Mus musculus 115-119 23143138-5 2013 Furthermore, the whole core transcription factor circuitry that control self-renewal of mouse ESC (Stat3-P-Tyr705, Oct4, Sox2 and Nanog) was strongly down-regulated by sodium arsenite (4 muM) exposure. sodium arsenite 168-183 SRY (sex determining region Y)-box 2 Mus musculus 121-125 23143138-5 2013 Furthermore, the whole core transcription factor circuitry that control self-renewal of mouse ESC (Stat3-P-Tyr705, Oct4, Sox2 and Nanog) was strongly down-regulated by sodium arsenite (4 muM) exposure. sodium arsenite 168-183 Nanog homeobox Mus musculus 130-135 23143138-7 2013 In contrast to mouse ESC with very low endogenous IL6, mouse neural stem/precursor cells (C17.2 clone immortalized by v-myc) with high endogenous production of IL6 exhibited a strong resistance to cytotoxic effects of sodium arsenite that could be decreased by inhibitory anti-IL6 antibody or Stat3 inhibition. sodium arsenite 218-233 interleukin 6 Mus musculus 160-163 23143138-7 2013 In contrast to mouse ESC with very low endogenous IL6, mouse neural stem/precursor cells (C17.2 clone immortalized by v-myc) with high endogenous production of IL6 exhibited a strong resistance to cytotoxic effects of sodium arsenite that could be decreased by inhibitory anti-IL6 antibody or Stat3 inhibition. sodium arsenite 218-233 interleukin 6 Mus musculus 160-163 23143138-8 2013 In summary, our data demonstrated suppression of self-renewal and induction of apoptosis in mouse ESC by sodium arsenite exposure, which was further accelerated due to simultaneous inhibition of the protective PI3K-AKT and Stat3-dependent pathways. sodium arsenite 105-120 thymoma viral proto-oncogene 1 Mus musculus 215-218 23143138-8 2013 In summary, our data demonstrated suppression of self-renewal and induction of apoptosis in mouse ESC by sodium arsenite exposure, which was further accelerated due to simultaneous inhibition of the protective PI3K-AKT and Stat3-dependent pathways. sodium arsenite 105-120 signal transducer and activator of transcription 3 Mus musculus 223-228 23229538-11 2013 Therefore, we thought PEDF played a role in cell apoptosis of liver and brain which induced by sodium arsenite exposure, and the results also demonstrated that Bax and Bcl-2 might be two key targets in the action of PEDF. sodium arsenite 95-110 serpin family F member 1 Rattus norvegicus 22-26 23229538-11 2013 Therefore, we thought PEDF played a role in cell apoptosis of liver and brain which induced by sodium arsenite exposure, and the results also demonstrated that Bax and Bcl-2 might be two key targets in the action of PEDF. sodium arsenite 95-110 serpin family F member 1 Rattus norvegicus 216-220 24368942-7 2013 Sodium arsenite significantly (P < 0.05) suppressed the glutathione peroxidase, catalase, superoxide dismutase activities with simultaneous induction of lipid peroxidation. sodium arsenite 0-15 catalase Rattus norvegicus 83-91 23165982-1 2013 This study examined whether S100A8 and S100A9, which comprise a complex called calprotectin, are upregulated by exposure to sodium arsenite [As(III)] in nine lines of human-derived cells. sodium arsenite 136-151 S100 calcium binding protein A8 Homo sapiens 28-34 23165982-1 2013 This study examined whether S100A8 and S100A9, which comprise a complex called calprotectin, are upregulated by exposure to sodium arsenite [As(III)] in nine lines of human-derived cells. sodium arsenite 136-151 S100 calcium binding protein A9 Homo sapiens 39-45 22963837-8 2012 In addition, CHO (25 mug/muL) inhibited not only the SA-induced cell apoptosis by up-regulating Bcl-2 level, but also the global DNA methylation by increasing the expressions of DNMT1 and DNMT3a. sodium arsenite 53-55 BCL2, apoptosis regulator Gallus gallus 96-101 22959463-6 2012 LCL exposed to sodium arsenite for 8-days induced expression of UPR-activated genes, including CHOP and GRP78, at the RNA and the protein level. sodium arsenite 15-30 DNA damage inducible transcript 3 Homo sapiens 95-99 22959463-6 2012 LCL exposed to sodium arsenite for 8-days induced expression of UPR-activated genes, including CHOP and GRP78, at the RNA and the protein level. sodium arsenite 15-30 heat shock protein family A (Hsp70) member 5 Homo sapiens 104-109 22683347-5 2012 We demonstrate that non cytotoxic concentrations of sodium arsenite (As(III), 0.25-2muM) significantly reduce T cell proliferation by increasing the percentage of non dividing cells blocked in G1 phase and by preventing cyclin D3 and CDC25A expression. sodium arsenite 52-67 latexin Homo sapiens 84-87 22683347-5 2012 We demonstrate that non cytotoxic concentrations of sodium arsenite (As(III), 0.25-2muM) significantly reduce T cell proliferation by increasing the percentage of non dividing cells blocked in G1 phase and by preventing cyclin D3 and CDC25A expression. sodium arsenite 52-67 cyclin D3 Homo sapiens 220-229 22683347-5 2012 We demonstrate that non cytotoxic concentrations of sodium arsenite (As(III), 0.25-2muM) significantly reduce T cell proliferation by increasing the percentage of non dividing cells blocked in G1 phase and by preventing cyclin D3 and CDC25A expression. sodium arsenite 52-67 cell division cycle 25A Homo sapiens 234-240 22824620-0 2012 Sodium arsenite-induced abnormalities in expressions of Caveolin-1, eNOS, IKKbeta, and COX-2 in SV-40 immortalized human uroepithelial cells and in urothelial carcinomas. sodium arsenite 0-15 caveolin 1 Homo sapiens 56-66 22824620-0 2012 Sodium arsenite-induced abnormalities in expressions of Caveolin-1, eNOS, IKKbeta, and COX-2 in SV-40 immortalized human uroepithelial cells and in urothelial carcinomas. sodium arsenite 0-15 nitric oxide synthase 3 Homo sapiens 68-72 22824620-0 2012 Sodium arsenite-induced abnormalities in expressions of Caveolin-1, eNOS, IKKbeta, and COX-2 in SV-40 immortalized human uroepithelial cells and in urothelial carcinomas. sodium arsenite 0-15 inhibitor of nuclear factor kappa B kinase subunit beta Homo sapiens 74-81 22824620-0 2012 Sodium arsenite-induced abnormalities in expressions of Caveolin-1, eNOS, IKKbeta, and COX-2 in SV-40 immortalized human uroepithelial cells and in urothelial carcinomas. sodium arsenite 0-15 mitochondrially encoded cytochrome c oxidase II Homo sapiens 87-92 22824620-3 2012 The aim of this study was to determine the effect of sodium arsenite on Caveolin-1 and downstream signaling molecules (eNOS, IKKbeta and COX-2) expression in human urothelial cells (SV-HUC-1). sodium arsenite 53-68 caveolin 1 Homo sapiens 72-82 22824620-3 2012 The aim of this study was to determine the effect of sodium arsenite on Caveolin-1 and downstream signaling molecules (eNOS, IKKbeta and COX-2) expression in human urothelial cells (SV-HUC-1). sodium arsenite 53-68 nitric oxide synthase 3 Homo sapiens 119-123 22829599-4 2012 Similarly treatment of cells with puromycin or sodium arsenite, reagents that arrest translation, also resulted in the accumulation of DEF6 in cytoplasmic granules. sodium arsenite 47-62 DEF6 guanine nucleotide exchange factor Homo sapiens 135-139 22580386-4 2012 Moreover, induction of HO-1 with sodium arsenite led to 2.4-fold (p = 0.01) accumulation of intracellular UCB over basal level while sodium azide-derived oxidative stress resulted in a 60% drop (p < 0.001). sodium arsenite 33-48 heme oxygenase 1 Homo sapiens 23-27 22931810-0 2012 [Mechanism of the apoptosis of rat pancreas islet beta cell strain (INS-1 cells) induced by sodium arsenite]. sodium arsenite 92-107 insulin 1 Rattus norvegicus 68-73 22931810-1 2012 OBJECTIVE: To study mechanism of the apoptosis of rat pancreas islet beta cell strain (INS-1 cells) induced by sodium arsenite. sodium arsenite 111-126 insulin 1 Rattus norvegicus 87-92 22931810-2 2012 METHODS: INS-1 cells were exposed to sodium arsenite at the different concentrations. sodium arsenite 37-52 insulin 1 Rattus norvegicus 9-14 22931810-5 2012 The apoptotic levels of INS-1 cells exposed to sodium arsenite were observed by a fluorescence microscope and flow cytometry. sodium arsenite 47-62 insulin 1 Rattus norvegicus 24-29 22931810-6 2012 RESULTS: After exposure to sodium arsenite, the viability of INS-1 cells significantly decreased with the doses of sodium arsenite. sodium arsenite 27-42 insulin 1 Rattus norvegicus 61-66 22931810-6 2012 RESULTS: After exposure to sodium arsenite, the viability of INS-1 cells significantly decreased with the doses of sodium arsenite. sodium arsenite 115-130 insulin 1 Rattus norvegicus 61-66 22931810-11 2012 The results detected with flow cytometry indicated that after exposure, the apoptotic INS-1E cells significantly increased with the doses of sodium arsenite. sodium arsenite 141-156 insulin 1 Rattus norvegicus 86-91 22931810-12 2012 CONCLUSIONS: The sodium arsenite can induce the apoptosis of INS-1 cells through the mitochondria-lysosome pathway. sodium arsenite 17-32 insulin 1 Rattus norvegicus 61-66 22627131-0 2012 Sodium arsenite down-regulates the expression of X-linked inhibitor of apoptosis protein via translational and post-translational mechanisms in hepatocellular carcinoma. sodium arsenite 0-15 X-linked inhibitor of apoptosis Homo sapiens 49-88 22627131-5 2012 In this study, we identified XIAP as a target for sodium arsenite-induced cytotoxicity in HCC. sodium arsenite 50-65 X-linked inhibitor of apoptosis Homo sapiens 29-33 22627131-6 2012 The exposure of HCC cell lines to sodium arsenite resulted in inhibition of XIAP expression in both a dose- and time-dependent manner. sodium arsenite 34-49 X-linked inhibitor of apoptosis Homo sapiens 76-80 22627131-7 2012 Sodium arsenite blocked the de novo XIAP synthesis and the activity of its internal ribosome entry site (IRES) element. sodium arsenite 0-15 X-linked inhibitor of apoptosis Homo sapiens 36-40 22627131-8 2012 Moreover, treatment with sodium arsenite decreased the protein stability of XIAP and induced its ubiquitin-proteasomal degradation. sodium arsenite 25-40 X-linked inhibitor of apoptosis Homo sapiens 76-80 22627131-9 2012 Overexpression of XIAP attenuated the pro-apoptotic effect of sodium arsenite in HCC. sodium arsenite 62-77 X-linked inhibitor of apoptosis Homo sapiens 18-22 22627131-10 2012 Taken together, our data demonstrate that sodium arsenite suppresses XIAP expression via translational and post-translational mechanisms in HCC. sodium arsenite 42-57 X-linked inhibitor of apoptosis Homo sapiens 69-73 22521605-7 2012 In addition, treatment of FvB mice with 100 ppb sodium arsenite in the drinking water for 6 months starting at weaning age resulted in dramatically higher levels of CRP in both the liver and inner medullary region of the kidney. sodium arsenite 48-63 C-reactive protein, pentraxin-related Mus musculus 165-168 25243001-3 2012 OBJECTIVE: The aim of this study was to investigate the harmful effects of sodium arsenite on sperm parameters and the antioxidant effects of Vit.E on sperm anomalies in sodium arsenite treated rats. sodium arsenite 170-185 vitrin Rattus norvegicus 142-145 25243001-12 2012 In sodium arsenite+Vit.E group, Vit.E could significantly compensate the harmful effects of sodium arsenite on sperm number, motility, viability and morphology compared to sodium arsenite group. sodium arsenite 3-18 vitrin Rattus norvegicus 32-35 25243001-12 2012 In sodium arsenite+Vit.E group, Vit.E could significantly compensate the harmful effects of sodium arsenite on sperm number, motility, viability and morphology compared to sodium arsenite group. sodium arsenite 92-107 vitrin Rattus norvegicus 19-22 25243001-12 2012 In sodium arsenite+Vit.E group, Vit.E could significantly compensate the harmful effects of sodium arsenite on sperm number, motility, viability and morphology compared to sodium arsenite group. sodium arsenite 92-107 vitrin Rattus norvegicus 32-35 25243001-12 2012 In sodium arsenite+Vit.E group, Vit.E could significantly compensate the harmful effects of sodium arsenite on sperm number, motility, viability and morphology compared to sodium arsenite group. sodium arsenite 92-107 vitrin Rattus norvegicus 19-22 25243001-12 2012 In sodium arsenite+Vit.E group, Vit.E could significantly compensate the harmful effects of sodium arsenite on sperm number, motility, viability and morphology compared to sodium arsenite group. sodium arsenite 92-107 vitrin Rattus norvegicus 32-35 25243001-13 2012 In addition, sperm viability and motility was significantly increased in rats treated with Vit.E alone compared to the control and sodium arsenite+Vit.E group. sodium arsenite 131-146 vitrin Rattus norvegicus 91-94 22331493-0 2012 Sodium arsenite +- hyperthermia sensitizes p53-expressing human ovarian cancer cells to cisplatin by modulating platinum-DNA damage responses. sodium arsenite 0-15 tumor protein p53 Homo sapiens 43-46 22331493-4 2012 In this study, we examined the role of p53 status in EOC response to a novel combination of cisplatin, sodium arsenite, and hyperthermia. sodium arsenite 103-118 tumor protein p53 Homo sapiens 39-42 22331493-5 2012 Human EOC cells were treated with cisplatin +- 20muM sodium arsenite at 37 C or 39 C for 1 h. Sodium arsenite +- hyperthermia sensitized wild-type p53-expressing (A2780, A2780/CP70, OVCA 420, OVCA 429, and OVCA 433) EOC cells to cisplatin. sodium arsenite 94-109 tumor protein p53 Homo sapiens 147-150 22331493-7 2012 P53 small interfering RNA (siRNA) transfection abrogated sodium arsenite sensitization effect. sodium arsenite 57-72 tumor protein p53 Homo sapiens 0-3 22331493-9 2012 Cotreatment with sodium arsenite +- hyperthermia attenuated cisplatin-induced XPC in wild-type p53-expressing cells. sodium arsenite 17-32 XPC complex subunit, DNA damage recognition and repair factor Homo sapiens 78-81 22331493-9 2012 Cotreatment with sodium arsenite +- hyperthermia attenuated cisplatin-induced XPC in wild-type p53-expressing cells. sodium arsenite 17-32 tumor protein p53 Homo sapiens 95-98 22331493-10 2012 XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin. sodium arsenite 95-110 XPC complex subunit, DNA damage recognition and repair factor Homo sapiens 0-3 22331493-10 2012 XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin. sodium arsenite 95-110 tumor protein p53 Homo sapiens 44-47 22331493-10 2012 XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin. sodium arsenite 95-110 XPC complex subunit, DNA damage recognition and repair factor Homo sapiens 142-145 22331493-10 2012 XPC siRNA transfection sensitized wild-type p53-expressing cells to cisplatin, suggesting that sodium arsenite +- hyperthermia attenuation of XPC is a mechanism by which wild-type p53-expressing cells are sensitized to cisplatin. sodium arsenite 95-110 tumor protein p53 Homo sapiens 180-183 22331493-11 2012 Hyperthermia +- sodium arsenite enhanced cellular and DNA accumulation of platinum in wild-type p53-expressing cells. sodium arsenite 16-31 tumor protein p53 Homo sapiens 96-99 22331493-13 2012 In conclusion, sodium arsenite +- hyperthermia sensitizes wild-type p53-expressing EOC cells to cisplatin by suppressing DNA repair protein XPC and increasing cellular and DNA platinum accumulation. sodium arsenite 15-30 tumor protein p53 Homo sapiens 68-71 22331493-13 2012 In conclusion, sodium arsenite +- hyperthermia sensitizes wild-type p53-expressing EOC cells to cisplatin by suppressing DNA repair protein XPC and increasing cellular and DNA platinum accumulation. sodium arsenite 15-30 XPC complex subunit, DNA damage recognition and repair factor Homo sapiens 140-143 22367689-2 2012 When HaCaT keratinocytes were exposed to 1-200muM sodium arsenite, we observed perinuclear localization of HDAC6 within 30 min. sodium arsenite 50-65 histone deacetylase 6 Homo sapiens 107-112 22367689-3 2012 Although the overall level of HDAC6 protein did not change, sodium arsenite caused an increase of HDAC6 in ribosomal fractions. sodium arsenite 60-75 histone deacetylase 6 Homo sapiens 98-103 22426358-0 2012 Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1. sodium arsenite 0-15 myogenin Mus musculus 44-52 22426358-0 2012 Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1. sodium arsenite 0-15 enhancer of zeste 2 polycomb repressive complex 2 subunit Mus musculus 139-143 22426358-0 2012 Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1. sodium arsenite 0-15 euchromatic histone methyltransferase 1 Mus musculus 145-148 22426358-0 2012 Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1. sodium arsenite 0-15 insulin-like growth factor 1 Mus musculus 154-159 22426358-2 2012 Previous studies indicate that 20 nM sodium arsenite exposure to C2C12 mouse myocyte cells delayed myoblast differentiation due to reduced myogenin expression, the transcription factor that differentiates myoblasts into myotubes. sodium arsenite 37-52 myogenin Mus musculus 139-147 22508046-2 2012 MiR-206 was characterized previously as a differentially expressed gene in sodium arsenite (SA)-induced neural tube defects (NTDs) in chick embryos via miRNA microarray analysis. sodium arsenite 75-90 microRNA 206 Gallus gallus 0-7 22508046-2 2012 MiR-206 was characterized previously as a differentially expressed gene in sodium arsenite (SA)-induced neural tube defects (NTDs) in chick embryos via miRNA microarray analysis. sodium arsenite 92-94 microRNA 206 Gallus gallus 0-7 22508046-4 2012 In this study we found differential expression of miR-206 in SA-treated chick embryos by Northern blot analysis. sodium arsenite 61-63 microRNA 206 Gallus gallus 50-57 22002864-3 2012 In this study, we found that inhibition of p38 MAPK with SB-203580 (SB) reduced H(2)O(2)-stimulated secretion of TNF-alpha, whereas pre-activation of p38 MAPK with sodium arsenite (SA) enhanced H(2)O(2)-stimulated secretion of TNF-alpha. sodium arsenite 164-179 mitogen-activated protein kinase 14 Homo sapiens 43-46 22002864-3 2012 In this study, we found that inhibition of p38 MAPK with SB-203580 (SB) reduced H(2)O(2)-stimulated secretion of TNF-alpha, whereas pre-activation of p38 MAPK with sodium arsenite (SA) enhanced H(2)O(2)-stimulated secretion of TNF-alpha. sodium arsenite 164-179 mitogen-activated protein kinase 14 Homo sapiens 150-153 22002864-3 2012 In this study, we found that inhibition of p38 MAPK with SB-203580 (SB) reduced H(2)O(2)-stimulated secretion of TNF-alpha, whereas pre-activation of p38 MAPK with sodium arsenite (SA) enhanced H(2)O(2)-stimulated secretion of TNF-alpha. sodium arsenite 181-183 mitogen-activated protein kinase 14 Homo sapiens 43-46 22002864-3 2012 In this study, we found that inhibition of p38 MAPK with SB-203580 (SB) reduced H(2)O(2)-stimulated secretion of TNF-alpha, whereas pre-activation of p38 MAPK with sodium arsenite (SA) enhanced H(2)O(2)-stimulated secretion of TNF-alpha. sodium arsenite 181-183 mitogen-activated protein kinase 14 Homo sapiens 150-153 22002864-5 2012 Finally, H(2)O(2)-induced apoptosis was attenuated by the inhibitors of p38 MAPK or reactive oxygen species (ROS), whereas it was enhanced by p38 MAPK agonist SA. sodium arsenite 159-161 mitogen-activated protein kinase 14 Homo sapiens 142-145 21954225-5 2012 METHODS: As-transformed p53lowHBECs were generated by exposing p53-knockdown HBECs to sodium arsenite (2.5 muM) for 16 weeks. sodium arsenite 86-101 tumor protein p53 Homo sapiens 24-27 22768106-6 2012 HSF1 was phosphorylated on S326 immediately after heat shock and was triggered by other cell stressors including proteasome inhibitors and sodium arsenite. sodium arsenite 139-154 heat shock transcription factor 1 Homo sapiens 0-4 21910007-1 2011 Treatment of melanoma cells by sodium arsenite or statins (simvastatin and lovastatin) dramatically modified activities of the main cell signaling pathways resulting in the induction of heme oxygenase-1 (HO-1) and in a downregulation of cyclooxygenase-2 (COX-2) protein levels. sodium arsenite 31-46 heme oxygenase 1 Homo sapiens 186-202 21910007-1 2011 Treatment of melanoma cells by sodium arsenite or statins (simvastatin and lovastatin) dramatically modified activities of the main cell signaling pathways resulting in the induction of heme oxygenase-1 (HO-1) and in a downregulation of cyclooxygenase-2 (COX-2) protein levels. sodium arsenite 31-46 heme oxygenase 1 Homo sapiens 204-208 21910007-1 2011 Treatment of melanoma cells by sodium arsenite or statins (simvastatin and lovastatin) dramatically modified activities of the main cell signaling pathways resulting in the induction of heme oxygenase-1 (HO-1) and in a downregulation of cyclooxygenase-2 (COX-2) protein levels. sodium arsenite 31-46 prostaglandin-endoperoxide synthase 2 Homo sapiens 237-253 21910007-1 2011 Treatment of melanoma cells by sodium arsenite or statins (simvastatin and lovastatin) dramatically modified activities of the main cell signaling pathways resulting in the induction of heme oxygenase-1 (HO-1) and in a downregulation of cyclooxygenase-2 (COX-2) protein levels. sodium arsenite 31-46 prostaglandin-endoperoxide synthase 2 Homo sapiens 255-260 21910007-4 2011 We demonstrated in the present study that treatment by sodium arsenite or statins with an additional inhibition of HO-1 expression (or activation) caused a substantial upregulation of apoptosis in melanoma cells. sodium arsenite 55-70 heme oxygenase 1 Homo sapiens 115-119 21596116-3 2011 GAL1 gene knockdown significantly attenuated sodium arsenite (NaAsO(2)) and arsenic trioxide (As(2)O(3)) inhibition of cell survival. sodium arsenite 45-60 lectin, galactose binding, soluble 1 Mus musculus 0-4 21819629-10 2011 JNK inhibition also inhibited TDP-43 SG localization in cells acutely treated with sodium arsenite and reduced the number of aggregates per cell in cultures transfected with C-terminal TDP-43 162-414 and 219-414 constructs. sodium arsenite 83-98 mitogen-activated protein kinase 8 Homo sapiens 0-3 21819629-10 2011 JNK inhibition also inhibited TDP-43 SG localization in cells acutely treated with sodium arsenite and reduced the number of aggregates per cell in cultures transfected with C-terminal TDP-43 162-414 and 219-414 constructs. sodium arsenite 83-98 TAR DNA binding protein Homo sapiens 30-36 21642427-0 2011 The ETS family transcription factor ELK-1 regulates induction of the cell cycle-regulatory gene p21(Waf1/Cip1) and the BAX gene in sodium arsenite-exposed human keratinocyte HaCaT cells. sodium arsenite 131-146 ETS transcription factor ELK1 Homo sapiens 36-41 21642427-0 2011 The ETS family transcription factor ELK-1 regulates induction of the cell cycle-regulatory gene p21(Waf1/Cip1) and the BAX gene in sodium arsenite-exposed human keratinocyte HaCaT cells. sodium arsenite 131-146 cyclin dependent kinase inhibitor 1A Homo sapiens 96-110 21642427-0 2011 The ETS family transcription factor ELK-1 regulates induction of the cell cycle-regulatory gene p21(Waf1/Cip1) and the BAX gene in sodium arsenite-exposed human keratinocyte HaCaT cells. sodium arsenite 131-146 BCL2 associated X, apoptosis regulator Homo sapiens 119-122 21642427-3 2011 Here, we show that ELK-1 directly trans-activates the p21 gene, independently of p53 and EGR-1, in sodium arsenite (NaASO(2))-exposed HaCaT cells. sodium arsenite 99-114 ETS transcription factor ELK1 Homo sapiens 19-24 21642427-3 2011 Here, we show that ELK-1 directly trans-activates the p21 gene, independently of p53 and EGR-1, in sodium arsenite (NaASO(2))-exposed HaCaT cells. sodium arsenite 99-114 cyclin dependent kinase inhibitor 1A Homo sapiens 54-57 21642427-6 2011 In addition, NaASO(2)-induced p21 promoter activity was enhanced by exogenous expression of ELK-1 and reduced by expression of siRNA targeted to ELK-1 mRNA. sodium arsenite 13-21 cyclin dependent kinase inhibitor 1A Homo sapiens 30-33 21642427-6 2011 In addition, NaASO(2)-induced p21 promoter activity was enhanced by exogenous expression of ELK-1 and reduced by expression of siRNA targeted to ELK-1 mRNA. sodium arsenite 13-21 ETS transcription factor ELK1 Homo sapiens 92-97 21642427-6 2011 In addition, NaASO(2)-induced p21 promoter activity was enhanced by exogenous expression of ELK-1 and reduced by expression of siRNA targeted to ELK-1 mRNA. sodium arsenite 13-21 ETS transcription factor ELK1 Homo sapiens 145-150 21861350-2 2011 METHODS: Chang hepatocytes were treated with 5, 10, 25 and 50 micromol/L of sodium arsenite (NaAsO2) for 6h, and RT-PCR were then performed to detect the mRNA expression of Nrf2, NQO1 and HO-1. sodium arsenite 76-91 NFE2 like bZIP transcription factor 2 Homo sapiens 173-177 21861350-3 2011 RESULTS: When exposed to 5, 10, 25 and 50 micromol/L of NaAsO2, Nrf2 mRNA were (100.74 +/- 3.70)%, (105.96 +/- 1.75)%, (101.76 +/- 1.01)% and (101.81 +/- 6.33)% of control,showing no statistic significance (P > 0.05). sodium arsenite 56-62 NFE2 like bZIP transcription factor 2 Homo sapiens 64-68 21861350-5 2011 Moreover, HO-1 mRNA expression were also significantly induced by sodium arsenite exposure, and a definite dose-effect relationship was confirmed (P < 0.01). sodium arsenite 66-81 heme oxygenase 1 Homo sapiens 10-14 21696631-10 2011 NaAsO2 prevented XPC induction by cisplatin; it maintained higher levels of MSH2 in tumors and enhanced initial accumulation of Pt in tumors. sodium arsenite 0-6 xeroderma pigmentosum, complementation group C Mus musculus 17-20 21696631-10 2011 NaAsO2 prevented XPC induction by cisplatin; it maintained higher levels of MSH2 in tumors and enhanced initial accumulation of Pt in tumors. sodium arsenite 0-6 mutS homolog 2 Mus musculus 76-80 21696631-11 2011 Combined NaAsO2 and hyperthermia decreased cisplatin-induced XPC 24 h after perfusion, maintained higher levels of MSH2 in tumors and significantly increased initial accumulation of Pt in tumors. sodium arsenite 9-15 xeroderma pigmentosum, complementation group C Mus musculus 61-64 21696631-11 2011 Combined NaAsO2 and hyperthermia decreased cisplatin-induced XPC 24 h after perfusion, maintained higher levels of MSH2 in tumors and significantly increased initial accumulation of Pt in tumors. sodium arsenite 9-15 mutS homolog 2 Mus musculus 115-119 21440049-3 2011 The present study stresses the hypothesis whether sodium arsenite, and its main metabolite, dimethylarsinic acid (DMA), may affect expression and processing of the amyloid precursor protein (APP), using the cholinergic cell line SN56.B5.G4 and primary neuronal cells overexpressing the Swedish mutation of APP, as experimental approaches. sodium arsenite 50-65 amyloid beta (A4) precursor protein Mus musculus 164-189 21440049-4 2011 Exposure of cholinergic SN56.B5.G4 cells with either sodium arsenite or DMA decreased cell viability in a concentration- and exposure-time dependent manner, and affected the activities of the cholinergic enzymes acetylcholinesterase and choline acetyltransferase. sodium arsenite 53-68 choline acetyltransferase Mus musculus 237-262 21234798-5 2011 In addition, we show that SMN deficiency sensitizes cells to sodium arsenite and H(2)O(2), two well-known stress inducers, leading to cell death at a much lower concentration of inducers in SMN knockdown cells than in control cells. sodium arsenite 61-76 survival of motor neuron 1, telomeric Homo sapiens 26-29 21427224-4 2011 In MC3T3-E1 cells, pretreatment with sphingosine 1-phosphate, sodium arsenite, or heat stress caused the attenuation of osteocalcin synthesis induced by BMP-4 or T3 with concurrent HSP27 induction. sodium arsenite 62-77 bone gamma-carboxyglutamate protein 2 Mus musculus 120-131 21427224-4 2011 In MC3T3-E1 cells, pretreatment with sphingosine 1-phosphate, sodium arsenite, or heat stress caused the attenuation of osteocalcin synthesis induced by BMP-4 or T3 with concurrent HSP27 induction. sodium arsenite 62-77 bone morphogenetic protein 4 Mus musculus 153-158 21427224-4 2011 In MC3T3-E1 cells, pretreatment with sphingosine 1-phosphate, sodium arsenite, or heat stress caused the attenuation of osteocalcin synthesis induced by BMP-4 or T3 with concurrent HSP27 induction. sodium arsenite 62-77 heat shock protein 1 Mus musculus 181-186 21292642-4 2011 We found that prolonged exposure of immortalized p53-knocked down human bronchial epithelial cells (p53(low)HBECs) to low levels of arsenite (NaAsO2, 2.5 muM) caused malignant transformation that was accompanied by epithelial to mesenchymal transition (EMT) and reduction in the levels of miR-200 family members. sodium arsenite 142-148 tumor protein p53 Homo sapiens 49-52 20390378-5 2011 The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3. sodium arsenite 4-10 tumor protein p53 Homo sapiens 54-57 20390378-5 2011 The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3. sodium arsenite 4-10 BCL2 apoptosis regulator Homo sapiens 89-94 20390378-5 2011 The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3. sodium arsenite 4-10 tumor protein p53 Homo sapiens 131-134 20390378-5 2011 The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3. sodium arsenite 188-194 tumor protein p53 Homo sapiens 54-57 20390378-5 2011 The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3. sodium arsenite 188-194 BCL2 apoptosis regulator Homo sapiens 89-94 20390378-5 2011 The NaAsO2 treatment resulted in a marked increase in p53 protein as early as 4 h and in Bcl-2 protein level by 12 h. In addition, p53 downregulation accompanied the combined treatment of NaAsO2 and Na2SeO3. sodium arsenite 188-194 tumor protein p53 Homo sapiens 131-134 20390378-6 2011 Thus, our results indicate upregulation of p53 and Bcl-2 play acrucial role in the NaAsO2-induced G1 arrest and apoptosis of A375 cells and that downregulation p53 appears to contribute to the inhibition by Na2SeO3 of the effects induced by NaAsO2. sodium arsenite 83-89 tumor protein p53 Homo sapiens 43-46 20390378-6 2011 Thus, our results indicate upregulation of p53 and Bcl-2 play acrucial role in the NaAsO2-induced G1 arrest and apoptosis of A375 cells and that downregulation p53 appears to contribute to the inhibition by Na2SeO3 of the effects induced by NaAsO2. sodium arsenite 83-89 BCL2 apoptosis regulator Homo sapiens 51-56 20390378-6 2011 Thus, our results indicate upregulation of p53 and Bcl-2 play acrucial role in the NaAsO2-induced G1 arrest and apoptosis of A375 cells and that downregulation p53 appears to contribute to the inhibition by Na2SeO3 of the effects induced by NaAsO2. sodium arsenite 83-89 tumor protein p53 Homo sapiens 160-163 20390378-6 2011 Thus, our results indicate upregulation of p53 and Bcl-2 play acrucial role in the NaAsO2-induced G1 arrest and apoptosis of A375 cells and that downregulation p53 appears to contribute to the inhibition by Na2SeO3 of the effects induced by NaAsO2. sodium arsenite 241-247 tumor protein p53 Homo sapiens 43-46 21266531-6 2011 We show that sodium arsenite induces ABCB6 expression in a dose-dependent manner both in mice fed sodium arsenite in drinking water and in cells exposed to sodium arsenite in vitro. sodium arsenite 13-28 ATP-binding cassette, sub-family B (MDR/TAP), member 6 Mus musculus 37-42 21266531-6 2011 We show that sodium arsenite induces ABCB6 expression in a dose-dependent manner both in mice fed sodium arsenite in drinking water and in cells exposed to sodium arsenite in vitro. sodium arsenite 98-113 ATP-binding cassette, sub-family B (MDR/TAP), member 6 Mus musculus 37-42 21266531-6 2011 We show that sodium arsenite induces ABCB6 expression in a dose-dependent manner both in mice fed sodium arsenite in drinking water and in cells exposed to sodium arsenite in vitro. sodium arsenite 98-113 ATP-binding cassette, sub-family B (MDR/TAP), member 6 Mus musculus 37-42 21266531-10 2011 Collectively, these results, obtained by both loss of function and gain of function analysis, suggest that ABCB6 expression in response to sodium arsenite might be an endogenous protective mechanism activated to protect cells against arsenite-induced oxidative stress. sodium arsenite 139-154 ATP binding cassette subfamily B member 6 (Langereis blood group) Homo sapiens 107-112 21281968-4 2011 We report that in vitro pre-treatment of PBMC with sodium arsenite (NaAs) reduces IL2 secretion and T cell proliferation induced by PHA, but does not prevent expression of monocyte-derived cytokines (IL1, IL6, TNFalpha) functioning as lymphocyte-activating factors. sodium arsenite 51-66 interleukin 2 Homo sapiens 82-85 21281968-4 2011 We report that in vitro pre-treatment of PBMC with sodium arsenite (NaAs) reduces IL2 secretion and T cell proliferation induced by PHA, but does not prevent expression of monocyte-derived cytokines (IL1, IL6, TNFalpha) functioning as lymphocyte-activating factors. sodium arsenite 51-66 tumor necrosis factor Homo sapiens 210-218 20965206-0 2011 Sodium arsenite delays the differentiation of C2C12 mouse myoblast cells and alters methylation patterns on the transcription factor myogenin. sodium arsenite 0-15 myogenin Mus musculus 133-141 20965206-4 2011 Exposing C2C12 cells to 20 nM sodium arsenite delayed the differentiation process, as evidenced by a significant reduction in the number of multinucleated myotubes, a decrease in myogenin mRNA expression, and a decrease in the total number of nuclei expressing myogenin protein. sodium arsenite 30-45 myogenin Mus musculus 179-187 20965206-4 2011 Exposing C2C12 cells to 20 nM sodium arsenite delayed the differentiation process, as evidenced by a significant reduction in the number of multinucleated myotubes, a decrease in myogenin mRNA expression, and a decrease in the total number of nuclei expressing myogenin protein. sodium arsenite 30-45 myogenin Mus musculus 261-269 20965206-9 2011 This study indicates that 20 nM sodium arsenite can alter myoblast differentiation by reducing the expression of the transcription factors myogenin and Mef2c, which is likely due to changes in promoter methylation patterns. sodium arsenite 32-47 myogenin Mus musculus 139-147 20965206-9 2011 This study indicates that 20 nM sodium arsenite can alter myoblast differentiation by reducing the expression of the transcription factors myogenin and Mef2c, which is likely due to changes in promoter methylation patterns. sodium arsenite 32-47 myocyte enhancer factor 2C Mus musculus 152-157 21643505-5 2011 While ten of the metals tested (cadmium, cobalt, copper, gold, iron, lead, mercury, silver, sodium arsenite and zinc) stimulated Nrf2-dependent transcriptional activity in at least three of the engineered cell lines, only three (cadmium, copper and sodium arsenite) were active in all five cell lines. sodium arsenite 92-107 NFE2 like bZIP transcription factor 2 Homo sapiens 129-133 21643505-5 2011 While ten of the metals tested (cadmium, cobalt, copper, gold, iron, lead, mercury, silver, sodium arsenite and zinc) stimulated Nrf2-dependent transcriptional activity in at least three of the engineered cell lines, only three (cadmium, copper and sodium arsenite) were active in all five cell lines. sodium arsenite 249-264 NFE2 like bZIP transcription factor 2 Homo sapiens 129-133 22181980-0 2011 Antagonistic role of tea against sodium arsenite-induced oxidative DNA damage and inhibition of DNA repair in Swiss albino mice. sodium arsenite 33-48 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 Mus musculus 21-24 22102309-4 2011 We have previously employed an in vitro model system of human epidermal keratinocytes to study the effects of submicromolar concentrations of sodium arsenite on cyclin D1 expression. sodium arsenite 142-157 cyclin D1 Homo sapiens 161-170 20980392-7 2010 Furthermore, DNA-damage-inducing agents doxorubicin, etoposide and sodium arsenite induced ferritin H mRNA expression in HIPK2(+/+) MEF cells, whereas it was significantly impaired in HIPK2(-/-) MEF cells. sodium arsenite 67-82 homeodomain interacting protein kinase 2 Homo sapiens 121-126 20980392-7 2010 Furthermore, DNA-damage-inducing agents doxorubicin, etoposide and sodium arsenite induced ferritin H mRNA expression in HIPK2(+/+) MEF cells, whereas it was significantly impaired in HIPK2(-/-) MEF cells. sodium arsenite 67-82 homeodomain interacting protein kinase 2 Homo sapiens 184-189 19826909-2 2010 Splenocytes harvested in presence of sodium arsenite expressed Heat shock protein 70 (HSP 70) which could be identified on the basis of relative migration pattern and western blot analysis. sodium arsenite 37-52 heat shock protein family A (Hsp70) member 2 Gallus gallus 63-84 19826909-2 2010 Splenocytes harvested in presence of sodium arsenite expressed Heat shock protein 70 (HSP 70) which could be identified on the basis of relative migration pattern and western blot analysis. sodium arsenite 37-52 heat shock protein family A (Hsp70) member 2 Gallus gallus 86-92 19826909-3 2010 Serum levels of HSP 70 in broiler chicken also increased after continuous feeding of sodium arsenite in drinking water. sodium arsenite 85-100 heat shock protein family A (Hsp70) member 2 Gallus gallus 16-22 19826909-5 2010 In vitro relative quantification of transcription level of HSP 70 revealed that splenocytes harvested in presence of sodium arsenite expressed (final concentration 3 and 7 muM/ml) more HSP 70 in comparison to cells harvested without sodium arsenite and the values were statistically significant (P < 0.001) when compared to untreated control. sodium arsenite 117-132 heat shock protein family A (Hsp70) member 2 Gallus gallus 59-65 19826909-5 2010 In vitro relative quantification of transcription level of HSP 70 revealed that splenocytes harvested in presence of sodium arsenite expressed (final concentration 3 and 7 muM/ml) more HSP 70 in comparison to cells harvested without sodium arsenite and the values were statistically significant (P < 0.001) when compared to untreated control. sodium arsenite 117-132 heat shock protein family A (Hsp70) member 2 Gallus gallus 185-191 20144955-3 2010 Administration of sodium arsenite (100 mg/kg/day) for 28 days in Sprague Dawley female rats resulted in significant reduction of biochemical parameters such as delta-aminolevulinic acid dehydratase (ALAD), reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and elevation of thiobarbituric acid reactive substances (TBARS) and the index of nitrite/nitrate (NOx) levels. sodium arsenite 18-33 aminolevulinate dehydratase Rattus norvegicus 160-197 20144955-3 2010 Administration of sodium arsenite (100 mg/kg/day) for 28 days in Sprague Dawley female rats resulted in significant reduction of biochemical parameters such as delta-aminolevulinic acid dehydratase (ALAD), reduced glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and elevation of thiobarbituric acid reactive substances (TBARS) and the index of nitrite/nitrate (NOx) levels. sodium arsenite 18-33 aminolevulinate dehydratase Rattus norvegicus 199-203 20144955-5 2010 Green tea crude fraction (GTC) co-treated with sodium arsenite for 28 days caused significant (p < .01) elevation of ALAD, GSH, GPx, SOD, and nitrate/nitrite levels and reduction of the TBARS level and tissue burden when compared to detannified green tea fraction (GTDT)-treated groups. sodium arsenite 47-62 aminolevulinate dehydratase Rattus norvegicus 120-124 19733843-5 2010 CD1 male mice were treated with different concentrations (0, 2.5, 5 or 10mg/kg/day) of sodium arsenite during 1, 3 or 9 days. sodium arsenite 87-102 CD1 antigen complex Mus musculus 0-3 20207026-3 2010 Since arsenic exposure prevents acclimation to seawater by decreasing CFTR protein levels we tested the hypothesis that arsenic (as sodium arsenite) blocks acclimation to seawater by down regulating SGK1 expression. sodium arsenite 132-147 serine/threonine-protein kinase Sgk1 Fundulus heteroclitus 199-203 20188806-3 2010 The results showed that folate deficiency significantly aggravated the NaAsO(2)-induced apoptotic progression [evidenced by phosphatidylserine externalization, cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP), collapse of mitochondrial potential, and release of cytochrome c from the mitochondria] and decrease of cell viability. sodium arsenite 71-79 caspase 3 Homo sapiens 172-214 20188806-3 2010 The results showed that folate deficiency significantly aggravated the NaAsO(2)-induced apoptotic progression [evidenced by phosphatidylserine externalization, cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP), collapse of mitochondrial potential, and release of cytochrome c from the mitochondria] and decrease of cell viability. sodium arsenite 71-79 poly(ADP-ribose) polymerase 1 Homo sapiens 216-220 20188806-3 2010 The results showed that folate deficiency significantly aggravated the NaAsO(2)-induced apoptotic progression [evidenced by phosphatidylserine externalization, cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP), collapse of mitochondrial potential, and release of cytochrome c from the mitochondria] and decrease of cell viability. sodium arsenite 71-79 cytochrome c, somatic Homo sapiens 275-287 20083128-4 2010 The present study investigates the role of heme oxygenase-1 (HO-1) in sodium arsenite-mediated angiogenesis in vitro. sodium arsenite 70-85 heme oxygenase 1 Homo sapiens 43-59 20083128-4 2010 The present study investigates the role of heme oxygenase-1 (HO-1) in sodium arsenite-mediated angiogenesis in vitro. sodium arsenite 70-85 heme oxygenase 1 Homo sapiens 61-65 20422371-1 2010 The present study has been designed to investigate the effect of rosiglitazone, a peroxisome proliferator activated receptor gamma agonist in sodium arsenite-induced vascular endothelial dysfunction (VED) in rats. sodium arsenite 142-157 peroxisome proliferator-activated receptor gamma Rattus norvegicus 82-130 20028703-1 2010 Sodium arsenite-exposed hepatocytes of rat showed higher production of nitric oxide (NO) and increased lipid peroxidation (LPO) level vis-a-vis activity of superoxide dismutase (SOD) and catalase (CAT) were significantly lowered. sodium arsenite 0-15 catalase Rattus norvegicus 187-195 20028703-1 2010 Sodium arsenite-exposed hepatocytes of rat showed higher production of nitric oxide (NO) and increased lipid peroxidation (LPO) level vis-a-vis activity of superoxide dismutase (SOD) and catalase (CAT) were significantly lowered. sodium arsenite 0-15 catalase Rattus norvegicus 197-200 20008137-1 2010 Sodium arsenite (NaAs)-induced autophagic cell death (ACD) of a mouse renal tubular epithelial cell line (mProx24), which expresses enhanced levels of interleukin-6 (IL-6), was reduced by the suppression of autophagy by 3-methyladenine or Atg7 knockdown. sodium arsenite 0-15 interleukin 6 Mus musculus 151-164 20008137-1 2010 Sodium arsenite (NaAs)-induced autophagic cell death (ACD) of a mouse renal tubular epithelial cell line (mProx24), which expresses enhanced levels of interleukin-6 (IL-6), was reduced by the suppression of autophagy by 3-methyladenine or Atg7 knockdown. sodium arsenite 0-15 interleukin 6 Mus musculus 166-170 20008137-1 2010 Sodium arsenite (NaAs)-induced autophagic cell death (ACD) of a mouse renal tubular epithelial cell line (mProx24), which expresses enhanced levels of interleukin-6 (IL-6), was reduced by the suppression of autophagy by 3-methyladenine or Atg7 knockdown. sodium arsenite 0-15 autophagy related 7 Mus musculus 239-243 20146381-1 2010 This study evaluated the involvement of hypophyseal-gonadal and hypophyseal-adrenal axes as a possible mechanism of sodium arsenite toxicity in ovary and uterus by the coadministration of hCG. sodium arsenite 116-131 chorionic gonadotropin subunit beta 5 Homo sapiens 188-191 20146381-2 2010 Subchronic treatment of 0.4 ppm of sodium arsenite/(100 g body weight day) via drinking water for seven estrous cycles significantly suppressed the plasma levels of leutinizing hormone, follicle-stimulating hormone, and estradiol along with sluggish ovarian activities of Delta(5),3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase followed by a reduction in gonadal tissue peroxidase activities in mature female rats at diestrous phase. sodium arsenite 35-50 aldo-keto reductase family 1, member C12 Rattus norvegicus 320-355 19766132-0 2009 Sodium arsenite alters cell cycle and MTHFR, MT1/2, and c-Myc protein levels in MCF-7 cells. sodium arsenite 0-15 methylenetetrahydrofolate reductase Homo sapiens 38-43 19766132-0 2009 Sodium arsenite alters cell cycle and MTHFR, MT1/2, and c-Myc protein levels in MCF-7 cells. sodium arsenite 0-15 metallothionein 1I, pseudogene Homo sapiens 45-50 19766132-0 2009 Sodium arsenite alters cell cycle and MTHFR, MT1/2, and c-Myc protein levels in MCF-7 cells. sodium arsenite 0-15 MYC proto-oncogene, bHLH transcription factor Homo sapiens 56-61 19766132-2 2009 Therefore, our aim was to evaluate the effects of sodium arsenite on the protein levels of methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) and its further relationship with the expression MT1/2 and c-myc in MCF-7 cells. sodium arsenite 50-65 methylenetetrahydrofolate reductase Homo sapiens 91-126 19766132-2 2009 Therefore, our aim was to evaluate the effects of sodium arsenite on the protein levels of methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) and its further relationship with the expression MT1/2 and c-myc in MCF-7 cells. sodium arsenite 50-65 methylenetetrahydrofolate reductase Homo sapiens 128-133 19766132-2 2009 Therefore, our aim was to evaluate the effects of sodium arsenite on the protein levels of methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) and its further relationship with the expression MT1/2 and c-myc in MCF-7 cells. sodium arsenite 50-65 dihydrofolate reductase Homo sapiens 139-162 19766132-2 2009 Therefore, our aim was to evaluate the effects of sodium arsenite on the protein levels of methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) and its further relationship with the expression MT1/2 and c-myc in MCF-7 cells. sodium arsenite 50-65 dihydrofolate reductase Homo sapiens 164-168 19766132-2 2009 Therefore, our aim was to evaluate the effects of sodium arsenite on the protein levels of methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) and its further relationship with the expression MT1/2 and c-myc in MCF-7 cells. sodium arsenite 50-65 metallothionein 1I, pseudogene Homo sapiens 219-224 19766132-2 2009 Therefore, our aim was to evaluate the effects of sodium arsenite on the protein levels of methylenetetrahydrofolate reductase (MTHFR) and dihydrofolate reductase (DHFR) and its further relationship with the expression MT1/2 and c-myc in MCF-7 cells. sodium arsenite 50-65 MYC proto-oncogene, bHLH transcription factor Homo sapiens 229-234 19577553-0 2009 Sodium arsenite-induced DAPK promoter hypermethylation and autophagy via ERK1/2 phosphorylation in human uroepithelial cells. sodium arsenite 0-15 death associated protein kinase 1 Homo sapiens 24-28 19577553-0 2009 Sodium arsenite-induced DAPK promoter hypermethylation and autophagy via ERK1/2 phosphorylation in human uroepithelial cells. sodium arsenite 0-15 mitogen-activated protein kinase 3 Homo sapiens 73-79 19536524-3 2009 NaAsO2 treatment (0-30 microM) was also found to induce phosphatidylserine externalization, a hallmark of apoptosis; to disrupt the mitochondrial membrane potential (Deltapsi ( m )); to cause the release of cytochrome c into the cytosol, and to trigger cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in a dose-dependent manner. sodium arsenite 0-6 cytochrome c, somatic Homo sapiens 207-219 19536524-3 2009 NaAsO2 treatment (0-30 microM) was also found to induce phosphatidylserine externalization, a hallmark of apoptosis; to disrupt the mitochondrial membrane potential (Deltapsi ( m )); to cause the release of cytochrome c into the cytosol, and to trigger cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in a dose-dependent manner. sodium arsenite 0-6 caspase 3 Homo sapiens 265-307 19536524-3 2009 NaAsO2 treatment (0-30 microM) was also found to induce phosphatidylserine externalization, a hallmark of apoptosis; to disrupt the mitochondrial membrane potential (Deltapsi ( m )); to cause the release of cytochrome c into the cytosol, and to trigger cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in a dose-dependent manner. sodium arsenite 0-6 poly(ADP-ribose) polymerase 1 Homo sapiens 309-313 19672740-3 2009 Investigating the responsible signalling cascades, it was found that NaAsO(2) administration activates mitogen-activated protein kinases (MAPKs) and NF-kappaB in oxidative stress mediated renal dysfunction and induced apoptotic cell death by the reciprocal regulation of Bcl-2/Bad in association with reducing mitochondrial membrane potential and increased cytosolic cytochrome C as well. sodium arsenite 69-77 nuclear factor kappa B subunit 1 Homo sapiens 149-158 19672740-3 2009 Investigating the responsible signalling cascades, it was found that NaAsO(2) administration activates mitogen-activated protein kinases (MAPKs) and NF-kappaB in oxidative stress mediated renal dysfunction and induced apoptotic cell death by the reciprocal regulation of Bcl-2/Bad in association with reducing mitochondrial membrane potential and increased cytosolic cytochrome C as well. sodium arsenite 69-77 BCL2 apoptosis regulator Homo sapiens 271-276 19672740-3 2009 Investigating the responsible signalling cascades, it was found that NaAsO(2) administration activates mitogen-activated protein kinases (MAPKs) and NF-kappaB in oxidative stress mediated renal dysfunction and induced apoptotic cell death by the reciprocal regulation of Bcl-2/Bad in association with reducing mitochondrial membrane potential and increased cytosolic cytochrome C as well. sodium arsenite 69-77 cytochrome c, somatic Homo sapiens 367-379 19575768-8 2009 The metalloid sodium arsenite induces skn-1-dependent activation of certain detoxification gene groups, including some that were not SKN-1-upregulated under normal conditions. sodium arsenite 14-29 BZIP domain-containing protein;Protein skinhead-1 Caenorhabditis elegans 38-43 19084030-5 2009 The present study investigates the effect of sodium arsenite and its metabolites monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III)) on CYP3A4, PXR, and RXR alpha expression in the small intestine of CYP3A4 transgenic mice. sodium arsenite 45-60 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 156-162 19084030-5 2009 The present study investigates the effect of sodium arsenite and its metabolites monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III)) on CYP3A4, PXR, and RXR alpha expression in the small intestine of CYP3A4 transgenic mice. sodium arsenite 45-60 nuclear receptor subfamily 1, group I, member 2 Mus musculus 164-167 19084030-5 2009 The present study investigates the effect of sodium arsenite and its metabolites monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III)) on CYP3A4, PXR, and RXR alpha expression in the small intestine of CYP3A4 transgenic mice. sodium arsenite 45-60 retinoid X receptor alpha Mus musculus 173-182 19084030-5 2009 The present study investigates the effect of sodium arsenite and its metabolites monomethylarsonous acid (MMA(III)) and dimethylarsinous acid (DMA(III)) on CYP3A4, PXR, and RXR alpha expression in the small intestine of CYP3A4 transgenic mice. sodium arsenite 45-60 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 220-226 19084030-6 2009 Sodium arsenite treatment increases mRNA, protein and CYP3A4 activity in a dose-dependent manner. sodium arsenite 0-15 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 54-60 19084030-10 2009 Sodium arsenite and both its metabolites increase PXR mRNA, while only DMA(III) induces RXR alpha expression. sodium arsenite 0-15 nuclear receptor subfamily 1, group I, member 2 Mus musculus 50-53 19084030-11 2009 Overall, these results suggest that sodium arsenite and its metabolites induce CYP3A4 expression by increasing PXR expression in the small intestine of CYP3A4 transgenic mice. sodium arsenite 36-51 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 79-85 19084030-11 2009 Overall, these results suggest that sodium arsenite and its metabolites induce CYP3A4 expression by increasing PXR expression in the small intestine of CYP3A4 transgenic mice. sodium arsenite 36-51 nuclear receptor subfamily 1, group I, member 2 Mus musculus 111-114 19084030-11 2009 Overall, these results suggest that sodium arsenite and its metabolites induce CYP3A4 expression by increasing PXR expression in the small intestine of CYP3A4 transgenic mice. sodium arsenite 36-51 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 152-158 19358893-0 2009 Simultaneous exposure of Xenopus A6 kidney epithelial cells to concurrent mild sodium arsenite and heat stress results in enhanced hsp30 and hsp70 gene expression and the acquisition of thermotolerance. sodium arsenite 79-94 heat shock protein 30E L homeolog Xenopus laevis 131-136 19358893-0 2009 Simultaneous exposure of Xenopus A6 kidney epithelial cells to concurrent mild sodium arsenite and heat stress results in enhanced hsp30 and hsp70 gene expression and the acquisition of thermotolerance. sodium arsenite 79-94 heat shock 70kDa protein L homeolog Xenopus laevis 141-146 19358893-1 2009 In this study, we examined the effect of concurrent low concentrations of sodium arsenite and mild heat shock temperatures on hsp30 and hsp70 gene expression in Xenopus A6 kidney epithelial cells. sodium arsenite 74-89 heat shock protein 30E L homeolog Xenopus laevis 126-131 19358893-1 2009 In this study, we examined the effect of concurrent low concentrations of sodium arsenite and mild heat shock temperatures on hsp30 and hsp70 gene expression in Xenopus A6 kidney epithelial cells. sodium arsenite 74-89 heat shock 70kDa protein L homeolog Xenopus laevis 136-141 19358893-2 2009 RNA blot hybridization and immunoblot analysis revealed that exposure of A6 cells to 1-10 microM sodium arsenite at a mild heat shock temperature of 30 degrees C enhanced hsp30 and hsp70 gene expression to a much greater extent than found with either stress individually. sodium arsenite 97-112 heat shock protein 30E L homeolog Xenopus laevis 171-176 19358893-2 2009 RNA blot hybridization and immunoblot analysis revealed that exposure of A6 cells to 1-10 microM sodium arsenite at a mild heat shock temperature of 30 degrees C enhanced hsp30 and hsp70 gene expression to a much greater extent than found with either stress individually. sodium arsenite 97-112 heat shock 70kDa protein L homeolog Xenopus laevis 181-186 19358893-3 2009 In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation. sodium arsenite 47-62 heat shock protein 30E L homeolog Xenopus laevis 127-132 19358893-3 2009 In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation. sodium arsenite 47-62 heat shock 70kDa protein L homeolog Xenopus laevis 137-150 19358893-3 2009 In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation. sodium arsenite 47-62 heat shock factor protein Xenopus laevis 232-236 19358893-3 2009 In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation. sodium arsenite 47-62 heat shock factor protein Xenopus laevis 316-320 19358893-3 2009 In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation. sodium arsenite 47-62 heat shock protein 30E L homeolog Xenopus laevis 361-366 19358893-3 2009 In cells treated simultaneously with 10 microM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26 degrees C with larger responses at 28 and 30 degrees C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation. sodium arsenite 47-62 heat shock 70kDa protein L homeolog Xenopus laevis 137-142 19580012-8 2009 The three single doses of sodium arsenite alone significantly (p<0.05) increased the rate of total structural Chromosomal Aberrations (CAs), rate of Sister Chromatid Exchanges (SCEs), micronucleus (MNs) formation, PARP and Lamia-A degradation and apoptosis as compared with the negative control. sodium arsenite 26-41 poly (ADP-ribose) polymerase family, member 1 Mus musculus 217-221 18996220-0 2009 Sodium arsenite induces ROS generation, DNA oxidative damage, HO-1 and c-Myc proteins, NF-kappaB activation and cell proliferation in human breast cancer MCF-7 cells. sodium arsenite 0-15 heme oxygenase 1 Homo sapiens 62-66 18996220-0 2009 Sodium arsenite induces ROS generation, DNA oxidative damage, HO-1 and c-Myc proteins, NF-kappaB activation and cell proliferation in human breast cancer MCF-7 cells. sodium arsenite 0-15 MYC proto-oncogene, bHLH transcription factor Homo sapiens 71-76 19010883-2 2008 We report here that treatment of cells with sodium arsenite at the concentrations close to environmental exposure is associated with the up-regulation of Hdm2 and the accumulation of p53 in the cytoplasm. sodium arsenite 44-59 MDM2 proto-oncogene Homo sapiens 154-158 19010883-2 2008 We report here that treatment of cells with sodium arsenite at the concentrations close to environmental exposure is associated with the up-regulation of Hdm2 and the accumulation of p53 in the cytoplasm. sodium arsenite 44-59 tumor protein p53 Homo sapiens 183-186 18809455-6 2008 The activity of brain and plasma acetylcholinesterase (AChE) was decreased in rats treated with Sa. sodium arsenite 96-98 acetylcholinesterase Rattus norvegicus 55-59 18809455-7 2008 Also, Sa significantly decreased plasma total protein (TP), albumin (Alb) and high density lipoprotein-cholesterol (HDL-c), while increased glucose, urea, creatinine, bilirubin, total lipid (TL), cholesterol, triglyceride (TG) and low density lipoprotein-cholesterol (LDL-c). sodium arsenite 6-8 albumin Rattus norvegicus 60-67 18809455-7 2008 Also, Sa significantly decreased plasma total protein (TP), albumin (Alb) and high density lipoprotein-cholesterol (HDL-c), while increased glucose, urea, creatinine, bilirubin, total lipid (TL), cholesterol, triglyceride (TG) and low density lipoprotein-cholesterol (LDL-c). sodium arsenite 6-8 albumin Rattus norvegicus 69-72 18675372-4 2008 In A6 cells subjected to sodium arsenite, cadmium chloride, herbimycin A or a 33 degrees C heat shock treatment, immunocytochemistry and confocal microscopy revealed that HSP30 accumulated primarily in the cytoplasm. sodium arsenite 25-40 heat shock protein 30E L homeolog Xenopus laevis 171-176 18606238-3 2008 Immunoblot analysis, using a homologous antibody, detected the presence of HSP110 in A6 cells maintained at 22 degrees C. The relative levels of HSP110 accumulation increased after heat shock or sodium arsenite treatment. sodium arsenite 195-210 heat shock protein family H (Hsp110) member 1 S homeolog Xenopus laevis 75-81 18606238-3 2008 Immunoblot analysis, using a homologous antibody, detected the presence of HSP110 in A6 cells maintained at 22 degrees C. The relative levels of HSP110 accumulation increased after heat shock or sodium arsenite treatment. sodium arsenite 195-210 heat shock protein family H (Hsp110) member 1 S homeolog Xenopus laevis 145-151 18606238-8 2008 Finally, A6 cells treated with 25 microM sodium arsenite produced very dense HSP110 structures primarily in the cytoplasm while HSP30 was enriched in the cytoplasm in a granular pattern. sodium arsenite 41-56 heat shock protein family H (Hsp110) member 1 S homeolog Xenopus laevis 77-83 18501396-0 2008 Mitotic arrest-associated apoptosis induced by sodium arsenite in A375 melanoma cells is BUBR1-dependent. sodium arsenite 47-62 BUB1 mitotic checkpoint serine/threonine kinase B Homo sapiens 89-94 18505831-0 2008 Sodium arsenite induces orphan nuclear receptor SHP gene expression via AMP-activated protein kinase to inhibit gluconeogenic enzyme gene expression. sodium arsenite 0-15 nuclear receptor subfamily 0 group B member 2 Homo sapiens 31-51 18505831-2 2008 In this study, we report that the sodium arsenite-induced gene expression of the small heterodimer partner (SHP; NR0B2), an atypical orphan nuclear receptor, regulates the expression of hepatic gluconeogenic genes. sodium arsenite 34-49 nuclear receptor subfamily 0 group B member 2 Homo sapiens 81-106 18505831-2 2008 In this study, we report that the sodium arsenite-induced gene expression of the small heterodimer partner (SHP; NR0B2), an atypical orphan nuclear receptor, regulates the expression of hepatic gluconeogenic genes. sodium arsenite 34-49 nuclear receptor subfamily 0 group B member 2 Homo sapiens 108-111 18505831-2 2008 In this study, we report that the sodium arsenite-induced gene expression of the small heterodimer partner (SHP; NR0B2), an atypical orphan nuclear receptor, regulates the expression of hepatic gluconeogenic genes. sodium arsenite 34-49 nuclear receptor subfamily 0 group B member 2 Homo sapiens 113-118 18505831-3 2008 Sodium arsenite augments hepatic SHP mRNA levels in an AMP-activated protein kinase (AMPK)-dependent manner. sodium arsenite 0-15 nuclear receptor subfamily 0 group B member 2 Homo sapiens 33-36 18505831-3 2008 Sodium arsenite augments hepatic SHP mRNA levels in an AMP-activated protein kinase (AMPK)-dependent manner. sodium arsenite 0-15 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 85-89 18505831-4 2008 Sodium arsenite activated AMPK and was shown to perturb cellular ATP levels. sodium arsenite 0-15 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 26-30 18505831-6 2008 We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase). sodium arsenite 67-82 nuclear receptor subfamily 0 group B member 2 Homo sapiens 48-51 18505831-6 2008 We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase). sodium arsenite 67-82 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 188-221 18505831-6 2008 We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase). sodium arsenite 67-82 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 223-228 18505831-6 2008 We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase). sodium arsenite 67-82 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 234-255 18505831-6 2008 We demonstrated the dose-dependent induction of SHP mRNA levels by sodium arsenite and repressed the forskolin/dexamethasone-induced gene expression of the key hepatic gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase). sodium arsenite 67-82 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 257-263 18505831-8 2008 Sodium arsenite inhibited the promoter activity of PEPCK and G6Pase, and this repression was abolished by small interfering (si)RNA SHP treatments. sodium arsenite 0-15 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 51-56 18505831-8 2008 Sodium arsenite inhibited the promoter activity of PEPCK and G6Pase, and this repression was abolished by small interfering (si)RNA SHP treatments. sodium arsenite 0-15 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 61-67 18505831-8 2008 Sodium arsenite inhibited the promoter activity of PEPCK and G6Pase, and this repression was abolished by small interfering (si)RNA SHP treatments. sodium arsenite 0-15 nuclear receptor subfamily 0 group B member 2 Homo sapiens 132-135 18505831-9 2008 The knockdown of SHP expression by oligonucleotide siRNA SHP or adenoviral siRNA SHP released the sodium arsenite-mediated repression of forskolin/dexamethasone-stimulated PEPCK and G6Pase gene expression in a variety of hepatic cell lines. sodium arsenite 98-113 nuclear receptor subfamily 0 group B member 2 Homo sapiens 17-20 18505831-9 2008 The knockdown of SHP expression by oligonucleotide siRNA SHP or adenoviral siRNA SHP released the sodium arsenite-mediated repression of forskolin/dexamethasone-stimulated PEPCK and G6Pase gene expression in a variety of hepatic cell lines. sodium arsenite 98-113 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 172-177 18505831-9 2008 The knockdown of SHP expression by oligonucleotide siRNA SHP or adenoviral siRNA SHP released the sodium arsenite-mediated repression of forskolin/dexamethasone-stimulated PEPCK and G6Pase gene expression in a variety of hepatic cell lines. sodium arsenite 98-113 glucose-6-phosphatase catalytic subunit 1 Homo sapiens 182-188 18505831-10 2008 Results from our study suggest that sodium arsenite induces SHP via AMPK to inhibit the expression of hepatic gluconeogenic genes and also provide us with a novel molecular mechanism of arsenite-mediated regulation of hepatic glucose homeostasis. sodium arsenite 36-51 nuclear receptor subfamily 0 group B member 2 Homo sapiens 60-63 18505831-10 2008 Results from our study suggest that sodium arsenite induces SHP via AMPK to inhibit the expression of hepatic gluconeogenic genes and also provide us with a novel molecular mechanism of arsenite-mediated regulation of hepatic glucose homeostasis. sodium arsenite 36-51 protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens 68-72 18476811-4 2008 Phosphorylation of Ago2 at serine-387 was significantly induced by treatment with sodium arsenite or anisomycin, and arsenite-induced phosphorylation was inhibited by a p38 MAPK (mitogen-activated protein kinase) inhibitor, but not by inhibitors of JNK (c-Jun N-terminal kinase) or MEK [MAPK/ERK (extracellular-signal-regulated kinase) kinase]. sodium arsenite 82-97 argonaute RISC catalytic component 2 Homo sapiens 19-23 18417180-3 2008 Previously, we reported that activation of the Nrf2-mediated cellular defense pathway confers protection against toxic effects induced by sodium arsenite [As(III)] or monomethylarsonous acid [MMA(III)]. sodium arsenite 138-153 NFE2 like bZIP transcription factor 2 Homo sapiens 47-51 18407307-3 2008 Intra-gastric exposure to arsenic (as sodium arsenite) for 30 days (1, 0.1, or 0.01 mg/kg/day), reduced the proportion of CD4+ cells and the CD4+/CD8+ ratio in the spleen, increasing the proportion of CD11b+ cells. sodium arsenite 38-53 integrin subunit alpha M Homo sapiens 201-206 18465250-1 2008 Sodium arsenite induces apoptosis in PC12 cells by activating the stress-activated p38 MAP kinase and the pro-apoptotic Bcl-2 family protein Bim(EL). sodium arsenite 0-15 mitogen activated protein kinase 14 Rattus norvegicus 83-86 18465250-1 2008 Sodium arsenite induces apoptosis in PC12 cells by activating the stress-activated p38 MAP kinase and the pro-apoptotic Bcl-2 family protein Bim(EL). sodium arsenite 0-15 BCL2, apoptosis regulator Rattus norvegicus 120-125 18465250-1 2008 Sodium arsenite induces apoptosis in PC12 cells by activating the stress-activated p38 MAP kinase and the pro-apoptotic Bcl-2 family protein Bim(EL). sodium arsenite 0-15 Bcl2-like 11 Rattus norvegicus 141-144 18465250-3 2008 Here, we report that sodium arsenite stimulates the protein expression and promoter activity of Bim(EL) in a p38-dependent manner. sodium arsenite 21-36 Bcl2-like 11 Rattus norvegicus 96-99 18465250-3 2008 Here, we report that sodium arsenite stimulates the protein expression and promoter activity of Bim(EL) in a p38-dependent manner. sodium arsenite 21-36 mitogen activated protein kinase 14 Rattus norvegicus 109-112 18465250-4 2008 Sodium arsenite also caused nuclear translocation of FOXO3a, indicative of FOXO3a activation. sodium arsenite 0-15 forkhead box O3 Rattus norvegicus 53-59 18465250-4 2008 Sodium arsenite also caused nuclear translocation of FOXO3a, indicative of FOXO3a activation. sodium arsenite 0-15 forkhead box O3 Rattus norvegicus 75-81 17999076-0 2008 Sodium arsenite modulates histone acetylation, histone deacetylase activity and HMGN protein dynamics in human cells. sodium arsenite 0-15 histone deacetylase 9 Homo sapiens 47-66 17999076-9 2008 Thus, our data suggest that NaAsO(2) induces chromatin opening by histone hyperacetylation due to HDAC inhibition and increase of the mobility of nucleosome-associated proteins. sodium arsenite 28-36 histone deacetylase 9 Homo sapiens 98-102 18404528-1 2008 Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells. sodium arsenite 51-66 heme oxygenase 1 Mus musculus 0-16 18404528-1 2008 Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells. sodium arsenite 51-66 heme oxygenase 1 Mus musculus 18-22 18404528-1 2008 Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells. sodium arsenite 51-66 nuclear factor, erythroid derived 2, like 2 Mus musculus 129-133 18404528-1 2008 Heme oxygenase-1 (HO-1) is markedly upregulated by sodium arsenite and previous studies implicated the transcriptional enhancers Nrf2 and AP-1 in arsenite-induced ho-1 gene expression in murine cells. sodium arsenite 51-66 heme oxygenase 1 Mus musculus 163-167 17941083-0 2008 Sodium arsenite induces heat shock protein 70 expression and protects against secretagogue-induced trypsinogen and NF-kappaB activation. sodium arsenite 0-15 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 24-45 17941083-5 2008 Our results showed that sodium arsenite pretreatment induced HSP70 expression both in vitro and in vivo and significantly ameliorated the severity of cerulein-induced pancreatitis, as evidenced by the markedly reduced degree of hyperamylasemia, pancreatic edema, and acinar cell necrosis. sodium arsenite 24-39 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 61-66 17941083-6 2008 Sodium arsenite pretreatment not only inhibited trypsinogen activation and the subcellular redistribution of cathepsin B, but also prevented NF-kappaB translocation to the nucleus by inhibiting the IkappaBalpha degradation both in vivo and in vitro. sodium arsenite 0-15 cathepsin B Rattus norvegicus 109-120 17941083-6 2008 Sodium arsenite pretreatment not only inhibited trypsinogen activation and the subcellular redistribution of cathepsin B, but also prevented NF-kappaB translocation to the nucleus by inhibiting the IkappaBalpha degradation both in vivo and in vitro. sodium arsenite 0-15 NFKB inhibitor alpha Rattus norvegicus 198-210 17941083-8 2008 Based on our observations we conclude that, like thermal stress, chemical stressors such as sodium arsenite also induce HSP70 expression in the pancreas and protect against acute pancreatitis. sodium arsenite 92-107 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 120-125 18191166-0 2008 Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite. sodium arsenite 91-106 keratin 6 Mus musculus 68-74 18222423-5 2008 Interestingly, resveratrol did not increase surface expression of DR5 in human melanomas, while gamma-irradiation or sodium arsenite treatment substantially upregulated DR5 expression. sodium arsenite 117-132 TNF receptor superfamily member 10b Homo sapiens 169-172 18197399-5 2008 Oral administration of NaAsO2 at a dose of 10 mg/kg body weight for 2 days caused significant accumulation of arsenic in cardiac tissues of the experimental mice in association with the reduction in cardiac antioxidant enzymes activities, namely superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase. sodium arsenite 23-29 catalase Mus musculus 268-276 18197399-5 2008 Oral administration of NaAsO2 at a dose of 10 mg/kg body weight for 2 days caused significant accumulation of arsenic in cardiac tissues of the experimental mice in association with the reduction in cardiac antioxidant enzymes activities, namely superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase. sodium arsenite 23-29 hematopoietic prostaglandin D synthase Mus musculus 278-303 18197399-5 2008 Oral administration of NaAsO2 at a dose of 10 mg/kg body weight for 2 days caused significant accumulation of arsenic in cardiac tissues of the experimental mice in association with the reduction in cardiac antioxidant enzymes activities, namely superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase. sodium arsenite 23-29 glutathione reductase Mus musculus 305-326 17804168-0 2008 Induction of heat shock protein 70 by sodium arsenite attenuates burn-induced intestinal injury in severe burned rats. sodium arsenite 38-53 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 13-34 17983699-5 2008 Moreover, AGE application in NaAsO(2) intoxicated Sprague-Dawley rats resulted in a marked inhibition of tissue lipid peroxide generation; enhanced level of total tissue sulfhydryl groups and glutathione; and also increased the activities of antioxidant enzymes, superoxide dismutase and catalase to near normal. sodium arsenite 29-37 catalase Rattus norvegicus 288-296 18273903-5 2008 Oral administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly decreased the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase, the level of cellular metabolites, reduced glutathione, total thiols and increased the level of oxidized glutathione. sodium arsenite 23-38 catalase Mus musculus 169-177 18273903-5 2008 Oral administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly decreased the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase, the level of cellular metabolites, reduced glutathione, total thiols and increased the level of oxidized glutathione. sodium arsenite 23-38 hematopoietic prostaglandin D synthase Mus musculus 179-204 18273903-5 2008 Oral administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly decreased the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione-S-transferase, glutathione reductase and glutathione peroxidase, the level of cellular metabolites, reduced glutathione, total thiols and increased the level of oxidized glutathione. sodium arsenite 23-38 glutathione reductase Mus musculus 206-227 17984221-5 2008 PRTB was recruited to SG under sodium arsenite and heat stress conditions. sodium arsenite 31-46 DAZ associated protein 2 Homo sapiens 0-4 17984221-7 2008 Knockdown of PRTB reduced the SG formation induced by sodium arsenite. sodium arsenite 54-69 DAZ associated protein 2 Homo sapiens 13-17 17938202-2 2007 We investigated expression of the essential base excision DNA repair enzyme apurinic endonuclease 1 (Ape1) in response to sodium arsenite. sodium arsenite 122-137 apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens 101-105 17945324-5 2007 These cells were treated with different doses of sodium arsenite (0, 0.1, 1, 5 and 10 microM) for 48 h. A greater reduction in cell viability was observed in the BEAS-2B cells vs. p53 compromised cells (H1355 or p53-inhibited BEAS-2B). sodium arsenite 49-64 tumor protein p53 Homo sapiens 180-183 17945324-5 2007 These cells were treated with different doses of sodium arsenite (0, 0.1, 1, 5 and 10 microM) for 48 h. A greater reduction in cell viability was observed in the BEAS-2B cells vs. p53 compromised cells (H1355 or p53-inhibited BEAS-2B). sodium arsenite 49-64 tumor protein p53 Homo sapiens 212-215 17928125-3 2007 K6/ODC mice develop skin tumors when exposed to 10ppm sodium arsenite for 5 months. sodium arsenite 54-69 ornithine decarboxylase, structural 1 Mus musculus 3-6 17910617-3 2007 Administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly reduced the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione S-transferase, glutathione reductase and glutathione peroxidase as well as depleted the level of reduced glutathione and total thiols. sodium arsenite 18-33 catalase Mus musculus 162-170 17910617-3 2007 Administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly reduced the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione S-transferase, glutathione reductase and glutathione peroxidase as well as depleted the level of reduced glutathione and total thiols. sodium arsenite 18-33 hematopoietic prostaglandin D synthase Mus musculus 172-197 17910617-3 2007 Administration of sodium arsenite at a dose of 10 mg/kg body weight for 2 days significantly reduced the activities of antioxidant enzymes, superoxide dismutase, catalase, glutathione S-transferase, glutathione reductase and glutathione peroxidase as well as depleted the level of reduced glutathione and total thiols. sodium arsenite 18-33 glutathione reductase Mus musculus 199-220 17619074-5 2007 In addition, AGS-R cells were cross-resistant to sodium arsenite and hydrogen peroxide, indicating that tolerance to oxidative stress might play a role in the development of resistance described in this investigation. sodium arsenite 49-64 jagged canonical Notch ligand 1 Homo sapiens 13-16 17906315-9 2007 Similarly, sodium arsenite stimulated a concentration-dependent increase in COX-2 expression. sodium arsenite 11-26 prostaglandin-endoperoxide synthase 2 Homo sapiens 76-81 17906315-10 2007 In conclusion, this study demonstrated that sodium arsenite is genotoxic to uroepithelial cells in vitro, and that it will induce expression of mutant p53 and COX-2 proteins, indicating a possible key event in carcinogenesis. sodium arsenite 44-59 tumor protein p53 Homo sapiens 151-154 17906315-10 2007 In conclusion, this study demonstrated that sodium arsenite is genotoxic to uroepithelial cells in vitro, and that it will induce expression of mutant p53 and COX-2 proteins, indicating a possible key event in carcinogenesis. sodium arsenite 44-59 prostaglandin-endoperoxide synthase 2 Homo sapiens 159-164 17707572-6 2007 The sequencing of four arsenite-sensitive RAPD bands showed that the RB1CC1 and PACE4 genes might be the DNA targets of sodium arsenite treatment. sodium arsenite 120-135 RB1 inducible coiled-coil 1 Homo sapiens 69-75 17707572-6 2007 The sequencing of four arsenite-sensitive RAPD bands showed that the RB1CC1 and PACE4 genes might be the DNA targets of sodium arsenite treatment. sodium arsenite 120-135 proprotein convertase subtilisin/kexin type 6 Homo sapiens 80-85 17340120-3 2007 We have previously observed that sodium arsenite (SA) induced the synthesis of CK18 protein and promotes a dose-related disruption of cytoplasmic CK18 filaments in a human hepatic cell line. sodium arsenite 33-48 keratin 18 Homo sapiens 79-83 17340120-3 2007 We have previously observed that sodium arsenite (SA) induced the synthesis of CK18 protein and promotes a dose-related disruption of cytoplasmic CK18 filaments in a human hepatic cell line. sodium arsenite 33-48 keratin 18 Homo sapiens 146-150 17340120-3 2007 We have previously observed that sodium arsenite (SA) induced the synthesis of CK18 protein and promotes a dose-related disruption of cytoplasmic CK18 filaments in a human hepatic cell line. sodium arsenite 50-52 keratin 18 Homo sapiens 79-83 17340120-3 2007 We have previously observed that sodium arsenite (SA) induced the synthesis of CK18 protein and promotes a dose-related disruption of cytoplasmic CK18 filaments in a human hepatic cell line. sodium arsenite 50-52 keratin 18 Homo sapiens 146-150 17340120-8 2007 Increased expression of CK18 was observed after exposure to SA. sodium arsenite 60-62 keratin 18 Mus musculus 24-28 17340120-11 2007 Mice treated with intragastric single doses of 2.5 and 5 mg/kg of SA showed an increased expression of CK18. sodium arsenite 66-68 keratin 18 Mus musculus 103-107 17545210-4 2007 Immunoblotting reveals that a 3-h treatment of U937 cells with 5 microM sodium arsenite results in a dramatic decrease in cdc25A protein levels. sodium arsenite 72-87 cell division cycle 25A Homo sapiens 122-128 17689208-0 2007 Expression of STAT3 and Bcl-6 oncoprotein in sodium arsenite-treated SV-40 immortalized human uroepithelial cells. sodium arsenite 45-60 signal transducer and activator of transcription 3 Homo sapiens 14-19 17689208-0 2007 Expression of STAT3 and Bcl-6 oncoprotein in sodium arsenite-treated SV-40 immortalized human uroepithelial cells. sodium arsenite 45-60 BCL6 transcription repressor Homo sapiens 24-29 17689208-7 2007 Sodium arsenite treatment reduced Jak-2 protein expression in a dose-dependent manner. sodium arsenite 0-15 Janus kinase 2 Homo sapiens 34-39 17467962-0 2007 Protective effects of hepatocellular canalicular conjugate export pump (Mrp2) on sodium arsenite-induced hepatic dysfunction in rats. sodium arsenite 81-96 ATP binding cassette subfamily B member 4 Rattus norvegicus 72-76 17545621-0 2007 Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. sodium arsenite 47-62 TNF superfamily member 10 Homo sapiens 88-93 17545621-8 2007 Moreover, sodium arsenite treatment may up-regulate expression of endogenous TRAIL and induces its translocation to cell surface and further down-regulates cFLIP levels in melanoma cells. sodium arsenite 10-25 TNF superfamily member 10 Homo sapiens 77-82 17479414-4 2007 Results showed that sodium arsenite induced significant cell proliferation at low concentrations (0.5 microM for 12, 24, and 48 h), but inhibited cell growth at high amounts (5 and 10 microM for 24 and 48 h), reflected as a beta concentration-response curve. sodium arsenite 20-35 amyloid beta precursor protein Homo sapiens 222-228 17479414-8 2007 Similarly, heat-shock protein 27 (HSP27) levels were increased by sodium arsenite of low concentrations with early exposure time (3, 6, and 12 h), but decreased with high metal concentrations with greater exposure time (24 and 48 h). sodium arsenite 66-81 heat shock protein family B (small) member 1 Homo sapiens 11-32 17479414-8 2007 Similarly, heat-shock protein 27 (HSP27) levels were increased by sodium arsenite of low concentrations with early exposure time (3, 6, and 12 h), but decreased with high metal concentrations with greater exposure time (24 and 48 h). sodium arsenite 66-81 heat shock protein family B (small) member 1 Homo sapiens 34-39 17479414-9 2007 Sodium arsenite decreased HSP70 expression at lower concentrations, but increased HSP70 expression at higher concentration. sodium arsenite 0-15 heat shock protein family A (Hsp70) member 4 Homo sapiens 26-31 17479414-9 2007 Sodium arsenite decreased HSP70 expression at lower concentrations, but increased HSP70 expression at higher concentration. sodium arsenite 0-15 heat shock protein family A (Hsp70) member 4 Homo sapiens 82-87 17242398-6 2007 In the present study, HO-1 was induced by either sodium arsenite (reactive oxygen species producer) or hemin or overexpressed in the murine macrophage-like cell line, RAW 264.7. sodium arsenite 49-64 heme oxygenase 1 Mus musculus 22-26 17009048-0 2007 Sodium arsenite-induced inhibition of cell proliferation is related to inhibition of IL-2 mRNA expression in mouse activated T cells. sodium arsenite 0-15 interleukin 2 Mus musculus 85-89 17224793-6 2007 In addition, SA treatment decreased cytomix-induced NO production and inducible NO synthase mRNA expression and decreased the levels of STAT1, STAT3, SOCS1, and SOCS3. sodium arsenite 13-15 nitric oxide synthase 2 Homo sapiens 70-91 17224793-6 2007 In addition, SA treatment decreased cytomix-induced NO production and inducible NO synthase mRNA expression and decreased the levels of STAT1, STAT3, SOCS1, and SOCS3. sodium arsenite 13-15 signal transducer and activator of transcription 1 Homo sapiens 136-141 17224793-6 2007 In addition, SA treatment decreased cytomix-induced NO production and inducible NO synthase mRNA expression and decreased the levels of STAT1, STAT3, SOCS1, and SOCS3. sodium arsenite 13-15 signal transducer and activator of transcription 3 Homo sapiens 143-148 17224793-6 2007 In addition, SA treatment decreased cytomix-induced NO production and inducible NO synthase mRNA expression and decreased the levels of STAT1, STAT3, SOCS1, and SOCS3. sodium arsenite 13-15 suppressor of cytokine signaling 1 Homo sapiens 150-155 17224793-6 2007 In addition, SA treatment decreased cytomix-induced NO production and inducible NO synthase mRNA expression and decreased the levels of STAT1, STAT3, SOCS1, and SOCS3. sodium arsenite 13-15 suppressor of cytokine signaling 3 Homo sapiens 161-166 17224793-7 2007 The SA treatment also decreased cytomix-induced IL-6 and IL-8 production in a dose-dependent manner. sodium arsenite 4-6 interleukin 6 Homo sapiens 48-52 17224793-7 2007 The SA treatment also decreased cytomix-induced IL-6 and IL-8 production in a dose-dependent manner. sodium arsenite 4-6 C-X-C motif chemokine ligand 8 Homo sapiens 57-61 17070520-0 2006 Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. sodium arsenite 0-15 TNF superfamily member 10 Homo sapiens 28-33 17070520-0 2006 Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. sodium arsenite 0-15 TNF receptor superfamily member 10a Homo sapiens 95-103 17070520-0 2006 Sodium arsenite accelerates TRAIL-mediated apoptosis in melanoma cells through upregulation of TRAIL-R1/R2 surface levels and downregulation of cFLIP expression. sodium arsenite 0-15 CASP8 and FADD like apoptosis regulator Homo sapiens 144-149 17070520-2 2006 Sodium arsenite is known to suppress both the IKK-NF-kappaB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis. sodium arsenite 0-15 Janus kinase 2 Homo sapiens 64-68 17070520-2 2006 Sodium arsenite is known to suppress both the IKK-NF-kappaB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis. sodium arsenite 0-15 signal transducer and activator of transcription 3 Homo sapiens 69-74 17070520-2 2006 Sodium arsenite is known to suppress both the IKK-NF-kappaB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis. sodium arsenite 0-15 mitogen-activated protein kinase 8 Homo sapiens 119-122 17070520-2 2006 Sodium arsenite is known to suppress both the IKK-NF-kappaB and JAK2-STAT3 signaling pathways and to activate the MAPK/JNK-cJun pathways, thereby committing some cancers to undergo apoptosis. sodium arsenite 0-15 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 123-127 17070520-5 2006 In the present study, we observed strong effects of sodium arsenite treatment on upregulation of TRAIL-mediated apoptosis in human and mouse melanomas. sodium arsenite 52-67 TNF superfamily member 10 Homo sapiens 97-102 17070520-7 2006 Furthermore, activation of cJun and suppression of NF-kappaB by sodium arsenite resulted in upregulation of the endogenous TRAIL and downregulation of the cFLIP gene expression (which encodes one of the main anti-apoptotic proteins in melanomas) followed by cFLIP protein degradation and, finally, by acceleration of TRAIL-induced apoptosis. sodium arsenite 64-79 TNF superfamily member 10 Homo sapiens 123-128 17070520-7 2006 Furthermore, activation of cJun and suppression of NF-kappaB by sodium arsenite resulted in upregulation of the endogenous TRAIL and downregulation of the cFLIP gene expression (which encodes one of the main anti-apoptotic proteins in melanomas) followed by cFLIP protein degradation and, finally, by acceleration of TRAIL-induced apoptosis. sodium arsenite 64-79 CASP8 and FADD like apoptosis regulator Homo sapiens 155-160 17070520-7 2006 Furthermore, activation of cJun and suppression of NF-kappaB by sodium arsenite resulted in upregulation of the endogenous TRAIL and downregulation of the cFLIP gene expression (which encodes one of the main anti-apoptotic proteins in melanomas) followed by cFLIP protein degradation and, finally, by acceleration of TRAIL-induced apoptosis. sodium arsenite 64-79 CASP8 and FADD like apoptosis regulator Homo sapiens 258-263 17070520-7 2006 Furthermore, activation of cJun and suppression of NF-kappaB by sodium arsenite resulted in upregulation of the endogenous TRAIL and downregulation of the cFLIP gene expression (which encodes one of the main anti-apoptotic proteins in melanomas) followed by cFLIP protein degradation and, finally, by acceleration of TRAIL-induced apoptosis. sodium arsenite 64-79 TNF superfamily member 10 Homo sapiens 317-322 17005224-2 2006 To gain insight into the oncogenic properties of arsenic, we studied the expression of cyclin D1 in cultured human epidermal keratinocytes treated with submicromolar concentrations of sodium arsenite. sodium arsenite 184-199 cyclin D1 Homo sapiens 87-96 17135312-6 2006 Immunodepletion of the NE with antibody against OGG1 or MYH decreased the incision of DNA adducts induced by As2O3, NaAsO2, monomethylarsonic acid, and dimethylarsinic acid, while antibodies against XPA, XPB, XPD, XPF, or XPG, did not. sodium arsenite 116-122 8-oxoguanine DNA glycosylase Homo sapiens 48-52 17135312-6 2006 Immunodepletion of the NE with antibody against OGG1 or MYH decreased the incision of DNA adducts induced by As2O3, NaAsO2, monomethylarsonic acid, and dimethylarsinic acid, while antibodies against XPA, XPB, XPD, XPF, or XPG, did not. sodium arsenite 116-122 mutY DNA glycosylase Homo sapiens 56-59 17003472-0 2006 Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression. sodium arsenite 43-58 interferon gamma Mus musculus 0-16 17003472-0 2006 Interferon-gamma plays protective roles in sodium arsenite-induced renal injury by up-regulating intrarenal multidrug resistance-associated protein 1 expression. sodium arsenite 43-58 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 108-149 16861019-5 2006 Hsp110 mRNA and/or protein was detected constitutively in A6 kidney epithelial cells and was inducible by heat shock, sodium arsenite, and cadmium chloride. sodium arsenite 118-133 heat shock protein family H (Hsp110) member 1 S homeolog Xenopus laevis 0-6 16600567-0 2006 Effects of sodium arsenite on catalase activity, gene and protein expression in HaCaT cells. sodium arsenite 11-26 catalase Homo sapiens 30-38 16600567-1 2006 The objective of this research work is to study the effects of sodium arsenite on activity, mRNA and protein expression of catalase (CAT) in established human cell lines of keratinocytes (HaCaT). sodium arsenite 63-78 catalase Homo sapiens 123-131 16600567-1 2006 The objective of this research work is to study the effects of sodium arsenite on activity, mRNA and protein expression of catalase (CAT) in established human cell lines of keratinocytes (HaCaT). sodium arsenite 63-78 catalase Homo sapiens 133-136 16600567-4 2006 CAT activity, mRNA expression and protein levels were decreased by 5-20 micromol/l of sodium arsenite. sodium arsenite 86-101 catalase Homo sapiens 0-3 17096945-0 2006 [Effects of sodium arsenite on catalase in human keratinocytes]. sodium arsenite 12-27 catalase Homo sapiens 31-39 17096945-1 2006 OBJECTIVE: To evaluate the effects of sodium arsenite on the activity, the mRNA and the protein expression of CAT in human keratinocyte cell line (HaCaT). sodium arsenite 38-53 catalase Homo sapiens 110-113 17096945-4 2006 RESULTS: If the cells were treated with higher than 5.0 micromol/L sodium arsenite, the activity, mRNA and protein expression of CAT were decreased significantly and in a dosage dependent fashion (P < 0.05). sodium arsenite 67-82 catalase Homo sapiens 129-132 17096945-5 2006 CONCLUSION: CAT is inhibited by sodium arsenite in the transcription, translation and activity levels. sodium arsenite 32-47 catalase Homo sapiens 12-15 16919243-8 2006 Nevertheless, we find significantly less co-localization of FMRP and TIA-1 and FMRP and its homologs in the neurites of differentiated PC12 cells treated with sodium arsenite than in the soma or growth cones. sodium arsenite 159-174 fragile X messenger ribonucleoprotein 1 Rattus norvegicus 60-64 16919243-8 2006 Nevertheless, we find significantly less co-localization of FMRP and TIA-1 and FMRP and its homologs in the neurites of differentiated PC12 cells treated with sodium arsenite than in the soma or growth cones. sodium arsenite 159-174 TIA1 cytotoxic granule-associated RNA binding protein Rattus norvegicus 69-74 16919243-8 2006 Nevertheless, we find significantly less co-localization of FMRP and TIA-1 and FMRP and its homologs in the neurites of differentiated PC12 cells treated with sodium arsenite than in the soma or growth cones. sodium arsenite 159-174 fragile X messenger ribonucleoprotein 1 Rattus norvegicus 79-83 16713074-4 2006 Treatments of Huh7-DRE-Luc and Huh7 with NaAsO2 attenuated the 2,3,7,8-TCDD-induced DRE-CALUX and cytochrome P450 1A1 (CYP1A1) activations, respectively, in a dose-dependent manner. sodium arsenite 41-47 MIR7-3 host gene Homo sapiens 14-18 16713074-4 2006 Treatments of Huh7-DRE-Luc and Huh7 with NaAsO2 attenuated the 2,3,7,8-TCDD-induced DRE-CALUX and cytochrome P450 1A1 (CYP1A1) activations, respectively, in a dose-dependent manner. sodium arsenite 41-47 MIR7-3 host gene Homo sapiens 31-35 16713074-4 2006 Treatments of Huh7-DRE-Luc and Huh7 with NaAsO2 attenuated the 2,3,7,8-TCDD-induced DRE-CALUX and cytochrome P450 1A1 (CYP1A1) activations, respectively, in a dose-dependent manner. sodium arsenite 41-47 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 98-117 16713074-4 2006 Treatments of Huh7-DRE-Luc and Huh7 with NaAsO2 attenuated the 2,3,7,8-TCDD-induced DRE-CALUX and cytochrome P450 1A1 (CYP1A1) activations, respectively, in a dose-dependent manner. sodium arsenite 41-47 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 119-125 16818494-6 2006 Here we report evidence that sodium arsenite-induced apoptosis in PC12 cells may be due to direct phosphorylation of Bim(EL) at Ser-65 by p38. sodium arsenite 29-44 mitogen activated protein kinase 14 Rattus norvegicus 138-141 16818494-8 2006 Furthermore, sodium arsenite induced Bim(EL) phosphorylation at Ser-65, which was blocked by p38 inhibition. sodium arsenite 13-28 mitogen activated protein kinase 14 Rattus norvegicus 93-96 16966277-5 2006 HL-60 and K562 were treated with arsenic trioxide (As2O3) and sodium arsenite (NaAsO2) at concentrations between 0 - 10 microM for up to 48 h. The induction of apoptosis was accompanied by down-regulation of hTERT and wt1 mRNA and protein expression but up-regulation of par-4. sodium arsenite 62-77 telomerase reverse transcriptase Homo sapiens 208-213 16966277-5 2006 HL-60 and K562 were treated with arsenic trioxide (As2O3) and sodium arsenite (NaAsO2) at concentrations between 0 - 10 microM for up to 48 h. The induction of apoptosis was accompanied by down-regulation of hTERT and wt1 mRNA and protein expression but up-regulation of par-4. sodium arsenite 62-77 WT1 transcription factor Homo sapiens 218-221 16966277-5 2006 HL-60 and K562 were treated with arsenic trioxide (As2O3) and sodium arsenite (NaAsO2) at concentrations between 0 - 10 microM for up to 48 h. The induction of apoptosis was accompanied by down-regulation of hTERT and wt1 mRNA and protein expression but up-regulation of par-4. sodium arsenite 62-77 Prader Willi/Angelman region RNA 4 Homo sapiens 271-276 16966277-5 2006 HL-60 and K562 were treated with arsenic trioxide (As2O3) and sodium arsenite (NaAsO2) at concentrations between 0 - 10 microM for up to 48 h. The induction of apoptosis was accompanied by down-regulation of hTERT and wt1 mRNA and protein expression but up-regulation of par-4. sodium arsenite 79-85 telomerase reverse transcriptase Homo sapiens 208-213 16966277-5 2006 HL-60 and K562 were treated with arsenic trioxide (As2O3) and sodium arsenite (NaAsO2) at concentrations between 0 - 10 microM for up to 48 h. The induction of apoptosis was accompanied by down-regulation of hTERT and wt1 mRNA and protein expression but up-regulation of par-4. sodium arsenite 79-85 WT1 transcription factor Homo sapiens 218-221 16966277-5 2006 HL-60 and K562 were treated with arsenic trioxide (As2O3) and sodium arsenite (NaAsO2) at concentrations between 0 - 10 microM for up to 48 h. The induction of apoptosis was accompanied by down-regulation of hTERT and wt1 mRNA and protein expression but up-regulation of par-4. sodium arsenite 79-85 Prader Willi/Angelman region RNA 4 Homo sapiens 271-276 16883109-9 2006 RESULTS: Higher expressions of Hsp-70 were observed in BECs, which were induced by sodium arsenite. sodium arsenite 83-98 heat shock protein family A (Hsp70) member 4 Homo sapiens 31-37 16530877-8 2006 Sodium arsenite, a strong inducer of oxidative stress and HO-1, reduced Bach1 expression in wild type Huh-7 cells, and NAC partially abrogated this decrease. sodium arsenite 0-15 heme oxygenase 1 Homo sapiens 58-62 16530877-8 2006 Sodium arsenite, a strong inducer of oxidative stress and HO-1, reduced Bach1 expression in wild type Huh-7 cells, and NAC partially abrogated this decrease. sodium arsenite 0-15 BTB domain and CNC homolog 1 Homo sapiens 72-77 16413591-5 2006 Insulin secretion and mRNA expression were evaluated in the presence of 1 and 5 microM sodium arsenite. sodium arsenite 87-102 insulin Homo sapiens 0-7 16413591-7 2006 We also showed a significant decrease in insulin mRNA expression of cells exposed to 5 microM sodium arsenite during 72 h. Our data suggest that arsenic may contribute to the development of diabetes mellitus by impairing pancreatic beta-cell functions, particularly insulin synthesis and secretion. sodium arsenite 94-109 insulin Homo sapiens 41-48 16497974-6 2006 Sodium arsenite was shown to down-regulate the expression of survivin at both the protein and RNA levels in a time- and dose-dependent manner, thus inhibiting cell growth, inducing apoptosis, and enhancing the caspase-3 activity in ATL cells. sodium arsenite 0-15 caspase 3 Homo sapiens 210-219 16497974-8 2006 Sodium arsenite suppressed the constitutive NF-kappaB activation by preventing the IkappaB-alpha degradation and the nuclear translocation of NF-kappaB. sodium arsenite 0-15 nuclear factor kappa B subunit 1 Homo sapiens 44-53 16497974-8 2006 Sodium arsenite suppressed the constitutive NF-kappaB activation by preventing the IkappaB-alpha degradation and the nuclear translocation of NF-kappaB. sodium arsenite 0-15 NFKB inhibitor alpha Homo sapiens 83-96 16497974-8 2006 Sodium arsenite suppressed the constitutive NF-kappaB activation by preventing the IkappaB-alpha degradation and the nuclear translocation of NF-kappaB. sodium arsenite 0-15 nuclear factor kappa B subunit 1 Homo sapiens 142-151 16497974-10 2006 Sodium arsenite was shown to down-regulate the expression of survivin through the NF-kappaB pathway, thus inhibiting cell growth and promoting apoptosis of ATL cells. sodium arsenite 0-15 nuclear factor kappa B subunit 1 Homo sapiens 82-91 16386761-3 2006 MGST1 activity was increased by ONOO(-) in the presence of high amounts of reducing agents including glutathione (GSH) and the activities increased by ONOO(-) or ONOO(-) plus GSH treatment were decreased by 30-40% by further incubation with dithiothreitol (DTT, reducing disulfide) or by sodium arsenite (reducing sulfenic acid). sodium arsenite 288-303 microsomal glutathione S-transferase 1 Rattus norvegicus 0-5 16487513-0 2006 Dual treatment with COX-2 inhibitor and sodium arsenite leads to induction of surface Fas Ligand expression and Fas-Ligand-mediated apoptosis in human melanoma cells. sodium arsenite 40-55 Fas ligand Homo sapiens 86-96 16487513-3 2006 We report here the use of a combination of sodium arsenite, an inhibitor of NF-kappaB activation, and NS398, a cyclooxygenase-2 (COX-2) inhibitor, for restoration of the surface FasL expression. sodium arsenite 43-58 Fas ligand Homo sapiens 178-182 16737587-16 2006 CONCLUSION: Sodium arsenite can induce expression of MRP2 and the up-regulation of MRP2 may play an important role in the bile secretion of arsenite and its metabolites. sodium arsenite 12-27 ATP binding cassette subfamily C member 2 Rattus norvegicus 53-57 16737587-16 2006 CONCLUSION: Sodium arsenite can induce expression of MRP2 and the up-regulation of MRP2 may play an important role in the bile secretion of arsenite and its metabolites. sodium arsenite 12-27 ATP binding cassette subfamily C member 2 Rattus norvegicus 83-87 16338954-4 2006 In this study, the effects of sodium arsenite on the expression of securin in two tissue types of cell lines, the vascular endothelial and colorectal epithelial cells, were investigated. sodium arsenite 30-45 PTTG1 regulator of sister chromatid separation, securin Homo sapiens 67-74 16483355-11 2006 Administration of human chorionic gonadotrophin (hCG) along with sodium arsenite partially prevented the degeneration of germ cells and enhanced paired testicular weights, epididymal sperm count, plasma and intratesticular testosterone concentrations, activities of delta 5, 3beta-HSD, 17 beta-HSD and sorbitol dehydrogenase along with diminution in the activities of ACP, ALP and LDH. sodium arsenite 65-80 hydroxysteroid (17-beta) dehydrogenase 3 Rattus norvegicus 286-297 16483355-11 2006 Administration of human chorionic gonadotrophin (hCG) along with sodium arsenite partially prevented the degeneration of germ cells and enhanced paired testicular weights, epididymal sperm count, plasma and intratesticular testosterone concentrations, activities of delta 5, 3beta-HSD, 17 beta-HSD and sorbitol dehydrogenase along with diminution in the activities of ACP, ALP and LDH. sodium arsenite 65-80 sorbitol dehydrogenase Homo sapiens 302-324 16483355-11 2006 Administration of human chorionic gonadotrophin (hCG) along with sodium arsenite partially prevented the degeneration of germ cells and enhanced paired testicular weights, epididymal sperm count, plasma and intratesticular testosterone concentrations, activities of delta 5, 3beta-HSD, 17 beta-HSD and sorbitol dehydrogenase along with diminution in the activities of ACP, ALP and LDH. sodium arsenite 65-80 alkaline phosphatase, placental Homo sapiens 373-376 16451733-3 2006 The mechanism of mammalian JNK activation by cadmium and sodium arsenite involves toxicant-induced oxidative stress. sodium arsenite 57-72 mitogen-activated protein kinase 8 Homo sapiens 27-30 16469751-9 2005 Sodium arsenite at low concentrations inhibited StAR protein but not mRNA expression and inhibited progesterone without disrupting delta psi(m). sodium arsenite 0-15 steroidogenic acute regulatory protein Mus musculus 48-52 16275621-0 2005 Differential effect of sodium arsenite during the activation of human CD4+ and CD8+ T lymphocytes. sodium arsenite 23-38 CD4 molecule Homo sapiens 70-73 16275621-0 2005 Differential effect of sodium arsenite during the activation of human CD4+ and CD8+ T lymphocytes. sodium arsenite 23-38 CD8a molecule Homo sapiens 79-82 16275621-4 2005 In this paper we tested the effect of 1-5 muM NaAsO2 on the proliferation, viability, blast transformation, expression of the CD4 and CD8 molecules, and during the activation and proliferation of both CD4+ and CD8+ T lymphocytes. sodium arsenite 46-52 CD4 molecule Homo sapiens 126-129 16275621-4 2005 In this paper we tested the effect of 1-5 muM NaAsO2 on the proliferation, viability, blast transformation, expression of the CD4 and CD8 molecules, and during the activation and proliferation of both CD4+ and CD8+ T lymphocytes. sodium arsenite 46-52 CD8a molecule Homo sapiens 134-137 16275621-7 2005 Analysis of the expression of CD4 and CD8 molecules on these cells showed that concentrations > or = 2 microM NaAsO2 reduced the expression of the CD8 molecule and induced apoptosis/death in CD4+ cells. sodium arsenite 113-119 CD4 molecule Homo sapiens 30-33 16275621-7 2005 Analysis of the expression of CD4 and CD8 molecules on these cells showed that concentrations > or = 2 microM NaAsO2 reduced the expression of the CD8 molecule and induced apoptosis/death in CD4+ cells. sodium arsenite 113-119 CD8a molecule Homo sapiens 38-41 16275621-7 2005 Analysis of the expression of CD4 and CD8 molecules on these cells showed that concentrations > or = 2 microM NaAsO2 reduced the expression of the CD8 molecule and induced apoptosis/death in CD4+ cells. sodium arsenite 113-119 CD8a molecule Homo sapiens 150-153 16275621-7 2005 Analysis of the expression of CD4 and CD8 molecules on these cells showed that concentrations > or = 2 microM NaAsO2 reduced the expression of the CD8 molecule and induced apoptosis/death in CD4+ cells. sodium arsenite 113-119 CD4 molecule Homo sapiens 194-197 16275621-8 2005 Analysis of blast transformation by flow cytometry showed an accumulation of CD8+ resting cells in the presence of NaAsO2. sodium arsenite 115-121 CD8a molecule Homo sapiens 77-80 16275621-10 2005 However, in the case of CD8+ cells, we detected an accumulation of a CD25- CD69- population in the presence of increasing concentrations of NaAsO2. sodium arsenite 140-146 CD8a molecule Homo sapiens 24-27 16275621-10 2005 However, in the case of CD8+ cells, we detected an accumulation of a CD25- CD69- population in the presence of increasing concentrations of NaAsO2. sodium arsenite 140-146 interleukin 2 receptor subunit alpha Homo sapiens 69-73 16275621-10 2005 However, in the case of CD8+ cells, we detected an accumulation of a CD25- CD69- population in the presence of increasing concentrations of NaAsO2. sodium arsenite 140-146 CD69 molecule Homo sapiens 75-79 16275621-11 2005 Altogether, our results show that NaAsO2 alters the expression kinetics of the early activation molecules CD25 and CD69 similarly in both subtypes. sodium arsenite 34-40 interleukin 2 receptor subunit alpha Homo sapiens 106-110 16275621-11 2005 Altogether, our results show that NaAsO2 alters the expression kinetics of the early activation molecules CD25 and CD69 similarly in both subtypes. sodium arsenite 34-40 CD69 molecule Homo sapiens 115-119 16125204-3 2005 The MGST1 activity increased by gallic acid was decreased by further incubation with sodium arsenite, a sulfenic acid reducing agent, but was not with dithiothreitol, a disulfide bond reducing agent. sodium arsenite 85-100 microsomal glutathione S-transferase 1 Rattus norvegicus 4-9 16283521-0 2005 Sodium arsenite-induced inhibition of eukaryotic translation initiation factor 4E (eIF4E) results in cytotoxicity and cell death. sodium arsenite 0-15 eukaryotic translation initiation factor 4E Homo sapiens 38-81 16283521-0 2005 Sodium arsenite-induced inhibition of eukaryotic translation initiation factor 4E (eIF4E) results in cytotoxicity and cell death. sodium arsenite 0-15 eukaryotic translation initiation factor 4E Homo sapiens 83-88 16283521-6 2005 All the NaAsO2-treated cells exhibited significant inhibition of eIF4E gene (protein). sodium arsenite 8-14 eukaryotic translation initiation factor 4E Homo sapiens 65-70 16283521-7 2005 The potential involvement of eIF4E gene expression in the NaAsO2-induced cytotoxicity and cell death was investigated by silencing the cellular expression of the eIF4E gene by employing a small interfering RNA (SiRNA) specifically targeting the eIF4E gene"s expression. sodium arsenite 58-64 eukaryotic translation initiation factor 4E Homo sapiens 29-34 16283521-7 2005 The potential involvement of eIF4E gene expression in the NaAsO2-induced cytotoxicity and cell death was investigated by silencing the cellular expression of the eIF4E gene by employing a small interfering RNA (SiRNA) specifically targeting the eIF4E gene"s expression. sodium arsenite 58-64 eukaryotic translation initiation factor 4E Homo sapiens 162-167 16283521-7 2005 The potential involvement of eIF4E gene expression in the NaAsO2-induced cytotoxicity and cell death was investigated by silencing the cellular expression of the eIF4E gene by employing a small interfering RNA (SiRNA) specifically targeting the eIF4E gene"s expression. sodium arsenite 58-64 eukaryotic translation initiation factor 4E Homo sapiens 162-167 16283521-8 2005 The SiRNA-mediated silencing of eIF4E gene expression also resulted in significant cytotoxicity and cell death suggesting that the toxicity noticed among the NaAsO2-treated cells was probably due to the chemically induced inhibition of eIF4E gene expression. sodium arsenite 158-164 eukaryotic translation initiation factor 4E Homo sapiens 32-37 16283521-8 2005 The SiRNA-mediated silencing of eIF4E gene expression also resulted in significant cytotoxicity and cell death suggesting that the toxicity noticed among the NaAsO2-treated cells was probably due to the chemically induced inhibition of eIF4E gene expression. sodium arsenite 158-164 eukaryotic translation initiation factor 4E Homo sapiens 236-241 16283521-9 2005 The potential involvement of inhibition of eIF4E gene expression in the NaAsO2-induced cytotoxicity and cell death was further investigated by employing transgenic cell lines overexpressing the eIF4E gene. sodium arsenite 72-78 eukaryotic translation initiation factor 4E Homo sapiens 43-48 16283521-9 2005 The potential involvement of inhibition of eIF4E gene expression in the NaAsO2-induced cytotoxicity and cell death was further investigated by employing transgenic cell lines overexpressing the eIF4E gene. sodium arsenite 72-78 eukaryotic translation initiation factor 4E Homo sapiens 194-199 16283521-10 2005 Overexpression of the eIF4E gene in the Chinese hamster ovary cell line was protective against the NaAsO2-induced cytotoxicity and cell death. sodium arsenite 99-105 eukaryotic translation initiation factor 4E Cricetulus griseus 22-27 16283521-11 2005 Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells. sodium arsenite 84-90 eukaryotic translation initiation factor 4E Homo sapiens 113-118 16283521-11 2005 Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells. sodium arsenite 84-90 eukaryotic translation initiation factor 4E Homo sapiens 223-228 16283521-11 2005 Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells. sodium arsenite 84-90 eukaryotic translation initiation factor 4E Gallus gallus 223-228 16283521-11 2005 Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells. sodium arsenite 165-171 eukaryotic translation initiation factor 4E Homo sapiens 113-118 16283521-11 2005 Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells. sodium arsenite 165-171 eukaryotic translation initiation factor 4E Homo sapiens 223-228 16283521-11 2005 Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells. sodium arsenite 165-171 eukaryotic translation initiation factor 4E Gallus gallus 223-228 16283521-11 2005 Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells. sodium arsenite 165-171 eukaryotic translation initiation factor 4E Homo sapiens 113-118 16283521-11 2005 Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells. sodium arsenite 165-171 eukaryotic translation initiation factor 4E Homo sapiens 223-228 16283521-11 2005 Additional studies conducted to understand the potential mechanisms responsible for NaAsO2-induced inhibition of eIF4E gene expression demonstrated that exposure to NaAsO2 resulted in transcriptional down-regulation of the eIF4E gene only in HCT-15 and HeLa cells, while in the NaAsO2-treated and PLC/PR/5 and Chang cells, the eIF4E mRNA expression level was comparable to those of the corresponding control cells. sodium arsenite 165-171 eukaryotic translation initiation factor 4E Gallus gallus 223-228 16283521-13 2005 Immunoprecipitation of lysates obtained from the NaAsO2-treated cells and the subsequent western blot analysis of the immunoprecipitated protein(s) using the eIF4E antibody detected the presence of eIF4E protein in the immunoprecipitate suggesting possible ubiquitination of eIF4E protein in the NaAsO2-treated cells. sodium arsenite 49-55 eukaryotic translation initiation factor 4E Homo sapiens 158-163 16283521-13 2005 Immunoprecipitation of lysates obtained from the NaAsO2-treated cells and the subsequent western blot analysis of the immunoprecipitated protein(s) using the eIF4E antibody detected the presence of eIF4E protein in the immunoprecipitate suggesting possible ubiquitination of eIF4E protein in the NaAsO2-treated cells. sodium arsenite 49-55 eukaryotic translation initiation factor 4E Homo sapiens 198-203 16283521-13 2005 Immunoprecipitation of lysates obtained from the NaAsO2-treated cells and the subsequent western blot analysis of the immunoprecipitated protein(s) using the eIF4E antibody detected the presence of eIF4E protein in the immunoprecipitate suggesting possible ubiquitination of eIF4E protein in the NaAsO2-treated cells. sodium arsenite 49-55 eukaryotic translation initiation factor 4E Homo sapiens 198-203 16283521-13 2005 Immunoprecipitation of lysates obtained from the NaAsO2-treated cells and the subsequent western blot analysis of the immunoprecipitated protein(s) using the eIF4E antibody detected the presence of eIF4E protein in the immunoprecipitate suggesting possible ubiquitination of eIF4E protein in the NaAsO2-treated cells. sodium arsenite 296-302 eukaryotic translation initiation factor 4E Homo sapiens 198-203 16283521-13 2005 Immunoprecipitation of lysates obtained from the NaAsO2-treated cells and the subsequent western blot analysis of the immunoprecipitated protein(s) using the eIF4E antibody detected the presence of eIF4E protein in the immunoprecipitate suggesting possible ubiquitination of eIF4E protein in the NaAsO2-treated cells. sodium arsenite 296-302 eukaryotic translation initiation factor 4E Homo sapiens 198-203 16283521-14 2005 Pre-exposure of the NaAsO2-treated cells to proteasome inhibitors blocked the inhibition of eIF4E gene expression as well as the resulting cytotoxicity and cell death. sodium arsenite 20-26 eukaryotic translation initiation factor 4E Homo sapiens 92-97 16283521-15 2005 Furthermore, exposure of cells to NaAsO2 resulted in a significant inhibition of expression of the cell cycle and growth regulating gene, cyclin D1. sodium arsenite 34-40 cyclin D1 Homo sapiens 138-147 16283521-17 2005 Transfection of cells with SiRNA specifically targeting eIF4E gene expression resulted in a significant inhibition of cyclin D1 gene suggesting that the observed inhibition of cyclin D1 gene in the NaAsO2-treated cells is most likely mediated through inhibition of eIF4E gene. sodium arsenite 198-204 eukaryotic translation initiation factor 4E Homo sapiens 56-61 16283521-17 2005 Transfection of cells with SiRNA specifically targeting eIF4E gene expression resulted in a significant inhibition of cyclin D1 gene suggesting that the observed inhibition of cyclin D1 gene in the NaAsO2-treated cells is most likely mediated through inhibition of eIF4E gene. sodium arsenite 198-204 cyclin D1 Homo sapiens 118-127 16283521-17 2005 Transfection of cells with SiRNA specifically targeting eIF4E gene expression resulted in a significant inhibition of cyclin D1 gene suggesting that the observed inhibition of cyclin D1 gene in the NaAsO2-treated cells is most likely mediated through inhibition of eIF4E gene. sodium arsenite 198-204 cyclin D1 Homo sapiens 176-185 16283521-17 2005 Transfection of cells with SiRNA specifically targeting eIF4E gene expression resulted in a significant inhibition of cyclin D1 gene suggesting that the observed inhibition of cyclin D1 gene in the NaAsO2-treated cells is most likely mediated through inhibition of eIF4E gene. sodium arsenite 198-204 eukaryotic translation initiation factor 4E Homo sapiens 265-270 16283521-18 2005 Taken together, our results indicate that the exposure of cells to NaAsO2 resulted in cytotoxicity and cell death, at least in part, due to the inhibition of eIF4E gene expression leading to diminished cellular levels of critical genes such as cyclin D1. sodium arsenite 67-73 eukaryotic translation initiation factor 4E Homo sapiens 158-163 16283521-18 2005 Taken together, our results indicate that the exposure of cells to NaAsO2 resulted in cytotoxicity and cell death, at least in part, due to the inhibition of eIF4E gene expression leading to diminished cellular levels of critical genes such as cyclin D1. sodium arsenite 67-73 cyclin D1 Homo sapiens 244-253 15689417-0 2005 Oxidative stress mediates sodium arsenite-induced expression of heme oxygenase-1, monocyte chemoattractant protein-1, and interleukin-6 in vascular smooth muscle cells. sodium arsenite 26-41 heme oxygenase 1 Homo sapiens 64-80 15689417-0 2005 Oxidative stress mediates sodium arsenite-induced expression of heme oxygenase-1, monocyte chemoattractant protein-1, and interleukin-6 in vascular smooth muscle cells. sodium arsenite 26-41 C-C motif chemokine ligand 2 Homo sapiens 82-116 15689417-0 2005 Oxidative stress mediates sodium arsenite-induced expression of heme oxygenase-1, monocyte chemoattractant protein-1, and interleukin-6 in vascular smooth muscle cells. sodium arsenite 26-41 interleukin 6 Homo sapiens 122-135 15741166-4 2005 Presently, small interference (si) RNA constructs were used to investigate the role of human BVR in sodium arsenite (As)-mediated induction of HO-1 and in cytoprotection against apoptosis. sodium arsenite 100-115 biliverdin reductase A Homo sapiens 93-96 15741166-4 2005 Presently, small interference (si) RNA constructs were used to investigate the role of human BVR in sodium arsenite (As)-mediated induction of HO-1 and in cytoprotection against apoptosis. sodium arsenite 100-115 heme oxygenase 1 Homo sapiens 143-147 16180985-4 2005 Up-regulation of HSP70 expression was demonstrated following treatment with menadione, CdCl2 and NaAsO2, but not with the other chemicals tested. sodium arsenite 97-103 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 17-22 16180985-5 2005 A shorter exposure time (6 hours) and/or the use of non-toxic concentrations reduced the level of HSP70 up-regulation with menadione, CdCl2 and NaAsO2, but did not uncover any up-regulation with the other chemicals. sodium arsenite 144-150 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 98-103 15537746-0 2005 Sodium arsenite exposure alters cell migration, focal adhesion localization and decreases tyrosine phosphorylation of focal adhesion kinase in H9C2 myoblasts. sodium arsenite 0-15 protein tyrosine kinase 2 Rattus norvegicus 118-139 15537746-9 2005 Sodium arsenite exposure resulted in reduced tyrosine phosphorylation of FAK, its substrate paxillin and the FAK auto- phosphorylation site, Tyr397. sodium arsenite 0-15 protein tyrosine kinase 2 Rattus norvegicus 73-76 15537746-9 2005 Sodium arsenite exposure resulted in reduced tyrosine phosphorylation of FAK, its substrate paxillin and the FAK auto- phosphorylation site, Tyr397. sodium arsenite 0-15 paxillin Rattus norvegicus 92-100 15537746-9 2005 Sodium arsenite exposure resulted in reduced tyrosine phosphorylation of FAK, its substrate paxillin and the FAK auto- phosphorylation site, Tyr397. sodium arsenite 0-15 protein tyrosine kinase 2 Rattus norvegicus 109-112 15893480-2 2005 In this study, immunocytochemical analysis and laser scanning confocal microscopy revealed that the shsp family, hsp30, was localized primarily in the cytoplasm of Xenopus A6 kidney epithelial cells after heat shock or sodium arsenite treatment. sodium arsenite 219-234 heat shock protein 30E L homeolog Xenopus laevis 113-118 15893480-4 2005 In sodium arsenite-treated cells hsp30 was enriched towards the cytoplasmic periphery as well as showing some immunostaining in the nucleus. sodium arsenite 3-18 heat shock protein 30E L homeolog Xenopus laevis 33-38 15893480-5 2005 At higher heat shock temperatures (35 degrees C) or after 10 microM sodium arsenite treatment, the actin cytoskeleton displayed some disorganization that co-localized with areas of hsp30 enrichment. sodium arsenite 68-83 heat shock protein 30E L homeolog Xenopus laevis 181-186 15611262-2 2005 In this study, we show that the activation of the cellular stress response, either by heat shock treatment or after exposure to sodium arsenite, leads to a transient inhibition of IkappaBalpha phosphorylation. sodium arsenite 128-143 NFKB inhibitor alpha Homo sapiens 180-192 16416669-0 2005 Chronic exposure to arsenic sensitizes CD3+ and CD56+ human cells to sodium arsenite-mediated apoptosis. sodium arsenite 69-84 neural cell adhesion molecule 1 Homo sapiens 48-52 15519606-3 2004 Our results reveal a significant increase in the degree of atherosclerotic plaque stenosis within the innominate artery of ApoE-/-/LDLr-/- mice treated with 10 ppm sodium arsenite (133 microM) in drinking water for 18 weeks compared to controls. sodium arsenite 164-179 apolipoprotein E Mus musculus 123-127 15519606-3 2004 Our results reveal a significant increase in the degree of atherosclerotic plaque stenosis within the innominate artery of ApoE-/-/LDLr-/- mice treated with 10 ppm sodium arsenite (133 microM) in drinking water for 18 weeks compared to controls. sodium arsenite 164-179 low density lipoprotein receptor Mus musculus 131-135 15476864-6 2004 SA augmented CDDP-induced increment of p27 but suppressed the increased expression of cyclin B1 and cyclin D1 at 3 days after CDDP. sodium arsenite 0-2 cyclin-dependent kinase inhibitor 1B Rattus norvegicus 39-42 15476864-6 2004 SA augmented CDDP-induced increment of p27 but suppressed the increased expression of cyclin B1 and cyclin D1 at 3 days after CDDP. sodium arsenite 0-2 cyclin B1 Rattus norvegicus 86-95 15476864-6 2004 SA augmented CDDP-induced increment of p27 but suppressed the increased expression of cyclin B1 and cyclin D1 at 3 days after CDDP. sodium arsenite 0-2 cyclin D1 Rattus norvegicus 100-109 15476864-7 2004 SA-induced attenuation of nephrotoxicity was associated with enhanced expression of proliferating cell nuclear antigen (PCNA) and growth-arrest and DNA damage (GADD) 153 in damaged tubular cells. sodium arsenite 0-2 proliferating cell nuclear antigen Rattus norvegicus 84-118 15476864-7 2004 SA-induced attenuation of nephrotoxicity was associated with enhanced expression of proliferating cell nuclear antigen (PCNA) and growth-arrest and DNA damage (GADD) 153 in damaged tubular cells. sodium arsenite 0-2 proliferating cell nuclear antigen Rattus norvegicus 120-124 15476864-8 2004 Our findings indicated that (1) proteins related to cell cycle regulation and DNA repair are induced in CDDP nephrotoxicity, (2) the SA-induced attenuation of CDDP nephrotoxicity is associated with increased expression of p27 and decreased expression of cyclin B1 and cyclin D1, they all induce cell cycle arrest at G1/S and G2/M, and (3) enhanced expression of DNA repair-related proteins is also associated with attenuation of CDDP-nephrotoxicity. sodium arsenite 133-135 cyclin-dependent kinase inhibitor 1B Rattus norvegicus 222-225 15476864-8 2004 Our findings indicated that (1) proteins related to cell cycle regulation and DNA repair are induced in CDDP nephrotoxicity, (2) the SA-induced attenuation of CDDP nephrotoxicity is associated with increased expression of p27 and decreased expression of cyclin B1 and cyclin D1, they all induce cell cycle arrest at G1/S and G2/M, and (3) enhanced expression of DNA repair-related proteins is also associated with attenuation of CDDP-nephrotoxicity. sodium arsenite 133-135 cyclin B1 Rattus norvegicus 254-263 15476864-8 2004 Our findings indicated that (1) proteins related to cell cycle regulation and DNA repair are induced in CDDP nephrotoxicity, (2) the SA-induced attenuation of CDDP nephrotoxicity is associated with increased expression of p27 and decreased expression of cyclin B1 and cyclin D1, they all induce cell cycle arrest at G1/S and G2/M, and (3) enhanced expression of DNA repair-related proteins is also associated with attenuation of CDDP-nephrotoxicity. sodium arsenite 133-135 cyclin D1 Rattus norvegicus 268-277 15327774-2 2004 The stress-inducible gene Hsp70 is activated by heat shock or by sodium arsenite. sodium arsenite 65-80 heat shock protein family A (Hsp70) member 4 Homo sapiens 26-31 15130612-8 2004 Early-passage cells showed dose-responsive caspase-3 activation following exposure to sodium arsenite, whereas caspase-3 activation of late-passage cells dropped to background levels at toxicant dosages above 50 ppb. sodium arsenite 86-101 caspase 3 Mus musculus 43-52 15217730-3 2004 Data presented in this study shows decreased expression of alpha- and beta-tubulin in wild type L. donovani promastigotes on exposure to NaAsO2 from 0.0016 to 5.0 microM (IC50 in the wild type strain) in a dose-dependent manner. sodium arsenite 137-143 alpha tubulin Leishmania donovani 59-82 14962831-3 2004 We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H(2)O(2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H(2)O(2)-stimulated ERK phosphorylation. sodium arsenite 162-177 mitogen-activated protein kinase 1 Homo sapiens 35-38 14962831-3 2004 We demonstrated that inhibition of p38 MAPK with SB-203580 and SB-239063 enhanced H(2)O(2)-stimulated ERK phosphorylation, whereas preactivation of p38 MAPK with sodium arsenite reduced H(2)O(2)-stimulated ERK phosphorylation. sodium arsenite 162-177 mitogen-activated protein kinase 1 Homo sapiens 148-151 15056798-0 2004 Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes. sodium arsenite 29-44 prostaglandin-endoperoxide synthase 2 Homo sapiens 52-68 15056798-0 2004 Micromolar concentrations of sodium arsenite induce cyclooxygenase-2 expression and stimulate p42/44 mitogen-activated protein kinase phosphorylation in normal human epidermal keratinocytes. sodium arsenite 29-44 cyclin dependent kinase 20 Homo sapiens 94-97 15116095-4 2004 Pretreatment with sodium arsenite strongly inhibited IL-6-inducible STAT3 tyrosine phosphorylation in HepG2 cells and did not affect its serine phosphorylation. sodium arsenite 18-33 signal transducer and activator of transcription 3 Homo sapiens 68-73 15116095-5 2004 As a result, sodium arsenite completely abolished STAT activity-dependent expression of suppressors of cytokine signaling (SOCS). sodium arsenite 13-28 cytokine inducible SH2 containing protein Homo sapiens 123-127 15085064-4 2004 This study assessed the effect of manidipine on normal subjects" monocyte gene and protein expression of OxSt-related proteins such as p22(phox), a NAD(P)H oxidase system subunit, critical in generating O2-, and heme oxygenase-1 (HO-1), induced by and protective from OxSt, and compared manidipine with the ACE inhibitor captopril and the calcium channel blocker nifedipine, in the presence and absence of sodium arsenite (NaAsO2) as an inducer of OxSt.Co-incubation of manidipine with NaAsO2 dose-dependently decreased p22(phox) mRNA production from basal: 0.87 +/- 0.1 d.u., 0.69 +/- 0.06 and 0.66 +/- 0.09 at 100, 300 and 500 nM respectively versus 0.99 +/- 0.2, P < 0.04, while HO-1 mRNA production was increased by the same concentrations of the drug: 0.87 +/- 0.1 d.u., 0.92 +/- 0.1, 0.98 +/- 0.1 respectively versus 0.63 +/- 0.07; P < 0.03. sodium arsenite 406-421 calcineurin like EF-hand protein 1 Homo sapiens 135-138 15085064-4 2004 This study assessed the effect of manidipine on normal subjects" monocyte gene and protein expression of OxSt-related proteins such as p22(phox), a NAD(P)H oxidase system subunit, critical in generating O2-, and heme oxygenase-1 (HO-1), induced by and protective from OxSt, and compared manidipine with the ACE inhibitor captopril and the calcium channel blocker nifedipine, in the presence and absence of sodium arsenite (NaAsO2) as an inducer of OxSt.Co-incubation of manidipine with NaAsO2 dose-dependently decreased p22(phox) mRNA production from basal: 0.87 +/- 0.1 d.u., 0.69 +/- 0.06 and 0.66 +/- 0.09 at 100, 300 and 500 nM respectively versus 0.99 +/- 0.2, P < 0.04, while HO-1 mRNA production was increased by the same concentrations of the drug: 0.87 +/- 0.1 d.u., 0.92 +/- 0.1, 0.98 +/- 0.1 respectively versus 0.63 +/- 0.07; P < 0.03. sodium arsenite 423-429 calcineurin like EF-hand protein 1 Homo sapiens 135-138 15085064-4 2004 This study assessed the effect of manidipine on normal subjects" monocyte gene and protein expression of OxSt-related proteins such as p22(phox), a NAD(P)H oxidase system subunit, critical in generating O2-, and heme oxygenase-1 (HO-1), induced by and protective from OxSt, and compared manidipine with the ACE inhibitor captopril and the calcium channel blocker nifedipine, in the presence and absence of sodium arsenite (NaAsO2) as an inducer of OxSt.Co-incubation of manidipine with NaAsO2 dose-dependently decreased p22(phox) mRNA production from basal: 0.87 +/- 0.1 d.u., 0.69 +/- 0.06 and 0.66 +/- 0.09 at 100, 300 and 500 nM respectively versus 0.99 +/- 0.2, P < 0.04, while HO-1 mRNA production was increased by the same concentrations of the drug: 0.87 +/- 0.1 d.u., 0.92 +/- 0.1, 0.98 +/- 0.1 respectively versus 0.63 +/- 0.07; P < 0.03. sodium arsenite 486-492 calcineurin like EF-hand protein 1 Homo sapiens 135-138 14673132-8 2004 Dexamethasone inhibited HSF1 binding at the Hsp70 promoter in response to heat or chemical shock (sodium arsenite). sodium arsenite 98-113 heat shock protein family A (Hsp70) member 4 Homo sapiens 44-49 14989901-6 2004 These results indicated that sodium arsenite increase p55 gene expression, and inhibited PL and HOXA10 gene expression. sodium arsenite 29-44 H3 histone pseudogene 44 Homo sapiens 54-57 14989901-6 2004 These results indicated that sodium arsenite increase p55 gene expression, and inhibited PL and HOXA10 gene expression. sodium arsenite 29-44 homeobox A10 Homo sapiens 96-102 14676650-12 2003 In in vitro studies, PMNLs from 10 healthy volunteers were incubated at 37 degrees C, 34 degrees C, or 26 degrees C for 1 hour with sodium arsenite (100 micromol/L), an HSP inducer. sodium arsenite 132-147 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 169-172 14594625-3 2003 Wild-type and ApoE-deficient mice were exposed to 20 or 100 microg/mL sodium arsenite in drinking water for 24 weeks. sodium arsenite 70-85 apolipoprotein E Mus musculus 14-18 14567983-4 2003 Thus, the effect of inorganic arsenic (as sodium arsenite) on Nrf2 expression and localization was studied in HaCaT cells, an immortalized human keratinocyte cell line. sodium arsenite 42-57 NFE2 like bZIP transcription factor 2 Homo sapiens 62-66 14523996-0 2003 Sodium arsenite downregulates transcriptional activity of AP-1 and CRE binding proteins in IL-1beta-treated Caco-2 cells by increasing the expression of the transcriptional repressor CREMalpha. sodium arsenite 0-15 interleukin 1 beta Homo sapiens 91-99 14523996-1 2003 In recent studies, sodium arsenite (SA) inhibited IL-6 production in cultured intestinal epithelial cells, at least in part by downregulating the activity of nuclear factor-kappaB (NF-kappaB). sodium arsenite 19-34 interleukin 6 Homo sapiens 50-54 14523996-1 2003 In recent studies, sodium arsenite (SA) inhibited IL-6 production in cultured intestinal epithelial cells, at least in part by downregulating the activity of nuclear factor-kappaB (NF-kappaB). sodium arsenite 36-38 interleukin 6 Homo sapiens 50-54 14523996-3 2003 We tested the effect of SA on the activity of CCAAT/enhancer binding protein (C/EBP), activating protein-1 (AP-1), and CRE binding proteins in IL-1beta-treated Caco-2 cells. sodium arsenite 24-26 CCAAT enhancer binding protein alpha Homo sapiens 46-76 14523996-3 2003 We tested the effect of SA on the activity of CCAAT/enhancer binding protein (C/EBP), activating protein-1 (AP-1), and CRE binding proteins in IL-1beta-treated Caco-2 cells. sodium arsenite 24-26 CCAAT enhancer binding protein alpha Homo sapiens 78-83 14523996-3 2003 We tested the effect of SA on the activity of CCAAT/enhancer binding protein (C/EBP), activating protein-1 (AP-1), and CRE binding proteins in IL-1beta-treated Caco-2 cells. sodium arsenite 24-26 interleukin 1 beta Homo sapiens 143-151 14523996-8 2003 The present results are consistent with the concept that SA inhibits IL-6 production in stimulated enterocytes by downregulating the transcriptional activity of several, but not all, IL-6-related transcription factors. sodium arsenite 57-59 interleukin 6 Homo sapiens 69-73 14523996-8 2003 The present results are consistent with the concept that SA inhibits IL-6 production in stimulated enterocytes by downregulating the transcriptional activity of several, but not all, IL-6-related transcription factors. sodium arsenite 57-59 interleukin 6 Homo sapiens 183-187 14606951-2 2003 Quercetin completely inhibited the synthesis and intracellular accumulation of 70-kD heat shock protein (HSP70) in response to hyperthermia or to treatment with sodium arsenite, whereas dihydroquercetin in the same or higher doses had no such effect. sodium arsenite 161-176 heat shock protein family A (Hsp70) member 4 Homo sapiens 85-110 12749847-3 2003 Both heat stress and sodium arsenite treatment in A6 cells resulted in a rapid activation of p38alpha and MAPKAPK-2. sodium arsenite 21-36 mitogen-activated protein kinase 14 S homeolog Xenopus laevis 93-101 12749847-3 2003 Both heat stress and sodium arsenite treatment in A6 cells resulted in a rapid activation of p38alpha and MAPKAPK-2. sodium arsenite 21-36 MAPK activated protein kinase 2 L homeolog Xenopus laevis 106-115 12637567-1 2003 Heme oxygenase-1 (HO-1) gene expression is induced by various oxidative stress stimuli including sodium arsenite. sodium arsenite 97-112 heme oxygenase 1 Rattus norvegicus 0-22 12637567-3 2003 The Jun N-terminal kinase (JNK) inhibitor SP600125 decreased sodium arsenite-mediated induction of HO-1 mRNA expression. sodium arsenite 61-76 mitogen-activated protein kinase 8 Rattus norvegicus 4-25 12637567-3 2003 The Jun N-terminal kinase (JNK) inhibitor SP600125 decreased sodium arsenite-mediated induction of HO-1 mRNA expression. sodium arsenite 61-76 mitogen-activated protein kinase 8 Rattus norvegicus 27-30 12637567-3 2003 The Jun N-terminal kinase (JNK) inhibitor SP600125 decreased sodium arsenite-mediated induction of HO-1 mRNA expression. sodium arsenite 61-76 heme oxygenase 1 Rattus norvegicus 99-103 12757736-0 2003 Sodium arsenite retards proliferation of PHA-activated T cells by delaying the production and secretion of IL-2. sodium arsenite 0-15 interleukin 2 Homo sapiens 107-111 12757736-3 2003 We reported previously a reduction in the secretion of IL-2 in NaAsO(2)-treated PBMCs stimulated with PHA, an observation that might explain, in part, the reduction in proliferation. sodium arsenite 63-71 interleukin 2 Homo sapiens 55-59 12842450-3 2003 This study investigated if SLH induces in vivo HSP72 expression and whether in vitro HSP72 induction by sodium arsenite (NaArs) alters intracellular signal transduction and cytokine production similar to SLH. sodium arsenite 104-119 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 85-90 12640124-3 2003 Here we investigated the ability of caveolin-1 to modulate the cellular response to sodium arsenite and thereby alter survival of the human cell lines 293 and HeLa. sodium arsenite 84-99 caveolin 1 Homo sapiens 36-46 12640124-4 2003 Cells stably transfected with caveolin-1 were found to be much more sensitive to the toxic effects of sodium arsenite than either untransfected parental cells or parental cells transfected with an empty vector. sodium arsenite 102-117 caveolin 1 Homo sapiens 30-40 12690470-9 2003 We also investigated the effect of co-administration of chelerythrine chloride (Chel), which inhibits the induction of HSPs, with SA on the expression of HSP72 and nephrotoxicity. sodium arsenite 130-132 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 154-159 12690470-10 2003 Pretreatment with UA or SA significantly induced renal HSP72 expression. sodium arsenite 24-26 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 55-60 12690470-12 2003 Co-administration of Chel with SA abolished the SA-induced increment of HSP72 and the beneficial effects of SA. sodium arsenite 31-33 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 72-77 12690470-12 2003 Co-administration of Chel with SA abolished the SA-induced increment of HSP72 and the beneficial effects of SA. sodium arsenite 48-50 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 72-77 12690470-12 2003 Co-administration of Chel with SA abolished the SA-induced increment of HSP72 and the beneficial effects of SA. sodium arsenite 48-50 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 72-77 12641444-7 2003 Of this group, arsenic trioxide was the strongest inducer of cellular p53, while dimethylarsinic acid, iododimethylarsine, and sodium arsenite also caused p53 induction in a dose- and time-dependent manner. sodium arsenite 127-142 tumor protein p53 Homo sapiens 155-158 12614848-2 2003 Here, we found that sodium arsenite (NaAsO(2)) also triggers the signal for activation of Akt and downstream glycogen synthase 3beta (GSK3beta). sodium arsenite 20-35 AKT serine/threonine kinase 1 Homo sapiens 90-93 12614848-2 2003 Here, we found that sodium arsenite (NaAsO(2)) also triggers the signal for activation of Akt and downstream glycogen synthase 3beta (GSK3beta). sodium arsenite 20-35 glycogen synthase kinase 3 beta Homo sapiens 134-142 12482858-0 2003 Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. sodium arsenite 138-153 mitogen-activated protein kinase 14 Homo sapiens 23-26 12482858-0 2003 Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite. sodium arsenite 138-153 vascular endothelial growth factor A Homo sapiens 89-123 12482858-1 2003 Recently we have demonstrated that sodium arsenite induces the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) protein and vascular endothelial growth factor (VEGF) in OVCAR-3 human ovarian cancer cells. sodium arsenite 35-50 hypoxia inducible factor 1 subunit alpha Homo sapiens 77-108 12482858-1 2003 Recently we have demonstrated that sodium arsenite induces the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) protein and vascular endothelial growth factor (VEGF) in OVCAR-3 human ovarian cancer cells. sodium arsenite 35-50 hypoxia inducible factor 1 subunit alpha Homo sapiens 110-120 12482858-1 2003 Recently we have demonstrated that sodium arsenite induces the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) protein and vascular endothelial growth factor (VEGF) in OVCAR-3 human ovarian cancer cells. sodium arsenite 35-50 vascular endothelial growth factor A Homo sapiens 134-168 12482858-1 2003 Recently we have demonstrated that sodium arsenite induces the expression of hypoxia-inducible factor 1alpha (HIF-1alpha) protein and vascular endothelial growth factor (VEGF) in OVCAR-3 human ovarian cancer cells. sodium arsenite 35-50 vascular endothelial growth factor A Homo sapiens 170-174 12482858-4 2003 By using kinase inhibitors in OVCAR-3 cells, both effects of sodium arsenite were found to be independent of phosphatidylinositol 3-kinase and p44/p42 MAPKS but were attenuated by inhibition of p38 MAPK. sodium arsenite 61-76 interferon induced protein 44 Homo sapiens 143-146 12482858-4 2003 By using kinase inhibitors in OVCAR-3 cells, both effects of sodium arsenite were found to be independent of phosphatidylinositol 3-kinase and p44/p42 MAPKS but were attenuated by inhibition of p38 MAPK. sodium arsenite 61-76 cyclin dependent kinase 20 Homo sapiens 147-150 12482858-4 2003 By using kinase inhibitors in OVCAR-3 cells, both effects of sodium arsenite were found to be independent of phosphatidylinositol 3-kinase and p44/p42 MAPKS but were attenuated by inhibition of p38 MAPK. sodium arsenite 61-76 mitogen-activated protein kinase 14 Homo sapiens 194-197 12482858-9 2003 Altogether, these data suggest that not HIF-1, but rather p38, mediates induction of VEGF mRNA expression by sodium arsenite. sodium arsenite 109-124 vascular endothelial growth factor A Homo sapiens 85-89 12388181-5 2003 IAP-I was also induced by sodium arsenite, which generates reactive oxygen species and is an inducer of members of the HSP family. sodium arsenite 26-41 alkaline phosphatase, intestinal Rattus norvegicus 0-5 12388181-5 2003 IAP-I was also induced by sodium arsenite, which generates reactive oxygen species and is an inducer of members of the HSP family. sodium arsenite 26-41 selenoprotein K Rattus norvegicus 119-122 13129816-5 2003 As(2)O(3)-induced apoptosis was associated with upregulation of p53 and caspase 3, whereas NaAsO(2)-induced apoptosis was associated with p53 upregulation. sodium arsenite 91-99 tumor protein p53 Homo sapiens 138-141 12460802-0 2002 Expression of hsp 27, hsp 60, hsc 70, and hsp 70 stress response genes in cultured human urothelial cells (UROtsa) exposed to lethal and sublethal concentrations of sodium arsenite. sodium arsenite 165-180 heat shock protein family B (small) member 1 Homo sapiens 14-20 12460802-0 2002 Expression of hsp 27, hsp 60, hsc 70, and hsp 70 stress response genes in cultured human urothelial cells (UROtsa) exposed to lethal and sublethal concentrations of sodium arsenite. sodium arsenite 165-180 heat shock protein family A (Hsp70) member 4 Homo sapiens 42-48 12460802-8 2002 In contrast, hsp 70 expression was induced by NaAsO2 after both acute and extended exposure. sodium arsenite 46-52 heat shock protein family A (Hsp70) member 4 Homo sapiens 13-19 12460802-9 2002 The degree and duration of the induction of the hsp 70 protein in the extended time course of exposure to NaAsO2 correlated directly with UROtsa cell cytotoxicity. sodium arsenite 106-112 heat shock protein family A (Hsp70) member 4 Homo sapiens 48-54 12241537-2 2002 We tested the hypothesis that sodium arsenite inhibits IL-6 production in stimulated enterocytes and that this effect of arsenite is caused by down-regulation of NF-kappaB activity. sodium arsenite 30-45 interleukin 6 Homo sapiens 55-59 12241537-7 2002 These effects of IL-1beta were inhibited by treatment of the cells with sodium arsenite in a dose- and time-dependent fashion. sodium arsenite 72-87 interleukin 1 beta Homo sapiens 17-25 12241537-8 2002 When cells were transfected with a plasmid expressing the p65 subunit of NF-kappaB, the inhibitory effect of sodium arsenite on NF-kappaB activity and IL-6 production was blunted. sodium arsenite 109-124 RELA proto-oncogene, NF-kB subunit Homo sapiens 58-82 12241537-8 2002 When cells were transfected with a plasmid expressing the p65 subunit of NF-kappaB, the inhibitory effect of sodium arsenite on NF-kappaB activity and IL-6 production was blunted. sodium arsenite 109-124 nuclear factor kappa B subunit 1 Homo sapiens 73-82 12241537-8 2002 When cells were transfected with a plasmid expressing the p65 subunit of NF-kappaB, the inhibitory effect of sodium arsenite on NF-kappaB activity and IL-6 production was blunted. sodium arsenite 109-124 interleukin 6 Homo sapiens 151-155 12241537-9 2002 These results suggest that sodium arsenite inhibits IL-6 production in enterocytes subjected to an inflammatory stimulus, and that this effect, at least in part, reflects down-regulated NF-kappaB activity. sodium arsenite 27-42 interleukin 6 Homo sapiens 52-56 12241537-9 2002 These results suggest that sodium arsenite inhibits IL-6 production in enterocytes subjected to an inflammatory stimulus, and that this effect, at least in part, reflects down-regulated NF-kappaB activity. sodium arsenite 27-42 nuclear factor kappa B subunit 1 Homo sapiens 186-195 12426128-0 2002 Sodium arsenite-induced stress-related gene expression in normal human epidermal, HaCaT, and HEL30 keratinocytes. sodium arsenite 0-15 crystallin lambda 1 Homo sapiens 93-98 12208374-3 2002 In the present study, we found that sodium arsenite induced downregulation of mRNA, protein expression, and enzyme activity of PHGPx in time- and dose-dependent manners. sodium arsenite 36-51 glutathione peroxidase 4 Homo sapiens 127-132 12208374-5 2002 With the aid of agarose gel electrophoresis, and propidium iodide and annexin-V staining, we found that treatment of 30 microM sodium arsenite for 24 h induced apoptosis in human epidermoid carcinoma A431 cells and EA.hy926 cells. sodium arsenite 127-142 annexin A5 Homo sapiens 70-79 12119132-0 2002 Expression of hsp 90 in the human kidney and in proximal tubule cells exposed to heat, sodium arsenite and cadmium chloride. sodium arsenite 87-102 heat shock protein 90 alpha family class A member 1 Homo sapiens 14-20 12076508-1 2002 Both acute (24 h) and chronic (10-20 week) exposure of human fibroblast cells to low dose sodium arsenite (As(III)) significantly affects activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) DNA binding activity. sodium arsenite 90-105 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 160-164 12076508-1 2002 Both acute (24 h) and chronic (10-20 week) exposure of human fibroblast cells to low dose sodium arsenite (As(III)) significantly affects activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) DNA binding activity. sodium arsenite 90-105 nuclear factor kappa B subunit 1 Homo sapiens 170-192 12076508-1 2002 Both acute (24 h) and chronic (10-20 week) exposure of human fibroblast cells to low dose sodium arsenite (As(III)) significantly affects activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) DNA binding activity. sodium arsenite 90-105 nuclear factor kappa B subunit 1 Homo sapiens 194-204 12482204-6 2002 Heat shock or sodium arsenite induced phosphorylation of both chimeric Hsp27 and Hsp27, which resulted in the disaggregation of Hsp27 multimers in both cell types and disaggregation of 20% of the chimeric multimers in L929 cells. sodium arsenite 14-29 heat shock protein 1 Mus musculus 71-76 12482204-6 2002 Heat shock or sodium arsenite induced phosphorylation of both chimeric Hsp27 and Hsp27, which resulted in the disaggregation of Hsp27 multimers in both cell types and disaggregation of 20% of the chimeric multimers in L929 cells. sodium arsenite 14-29 heat shock protein 1 Mus musculus 81-86 12482204-6 2002 Heat shock or sodium arsenite induced phosphorylation of both chimeric Hsp27 and Hsp27, which resulted in the disaggregation of Hsp27 multimers in both cell types and disaggregation of 20% of the chimeric multimers in L929 cells. sodium arsenite 14-29 heat shock protein 1 Mus musculus 81-86 12141822-0 2002 Induction of HSP72 by sodium arsenite fails to protect against cholecystokinin-octapeptide-induced acute pancreatitis in rats. sodium arsenite 22-37 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 13-18 12141822-6 2002 HWI and the injection of sodium arsenite significantly elevated the expression of HSP72 in the pancreas and lungs, whereas they did not influence the levels of HSP60. sodium arsenite 25-40 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 82-87 12141822-8 2002 In contrast, the nonthermal preinduction of HSP72 by sodium arsenite did not result in any beneficial effects on the measured parameters of the disease. sodium arsenite 53-68 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 44-49 12095131-9 2002 In additional experiments, treatment of mice with sodium arsenite after induction of endotoxemia blunted the increase in NF-kappaB activity, indicating a therapeutic potential of sodium arsenite, in addition to its preventive effect. sodium arsenite 50-65 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 121-130 12095131-9 2002 In additional experiments, treatment of mice with sodium arsenite after induction of endotoxemia blunted the increase in NF-kappaB activity, indicating a therapeutic potential of sodium arsenite, in addition to its preventive effect. sodium arsenite 179-194 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 121-130 12075113-5 2002 These studies revealed a differential requirement for the c-Jun N-terminal kinase (JNK) pathway for apoptosis induction by sodium arsenite in the resistant EW36 versus sensitive ST486 cell lines. sodium arsenite 123-138 mitogen-activated protein kinase 8 Homo sapiens 58-81 12075113-5 2002 These studies revealed a differential requirement for the c-Jun N-terminal kinase (JNK) pathway for apoptosis induction by sodium arsenite in the resistant EW36 versus sensitive ST486 cell lines. sodium arsenite 123-138 mitogen-activated protein kinase 8 Homo sapiens 83-86 12085988-7 2002 L-azetidine-2-carboxylic acid, sodium arsenite, CdCl2 and ZnCI2 caused induction of both isoforms of the hsp70 genes, even though their expression levels were variable. sodium arsenite 31-46 heat shock protein 1B Mus musculus 105-110 12016150-0 2002 Sodium arsenite administration via drinking water increases genome-wide and Ha-ras DNA hypomethylation in methyl-deficient C57BL/6J mice. sodium arsenite 0-15 Harvey rat sarcoma virus oncogene Mus musculus 76-82 12016150-8 2002 Sodium arsenite increased genomic hypomethylation in a dose dependent manner and methyl-deficiency and sodium arsenite reduced the frequency of methylation at several cytosine sites within the promoter region of the oncogenic gene, Ha-ras. sodium arsenite 0-15 Harvey rat sarcoma virus oncogene Mus musculus 232-238 12016150-8 2002 Sodium arsenite increased genomic hypomethylation in a dose dependent manner and methyl-deficiency and sodium arsenite reduced the frequency of methylation at several cytosine sites within the promoter region of the oncogenic gene, Ha-ras. sodium arsenite 103-118 Harvey rat sarcoma virus oncogene Mus musculus 232-238 12054599-0 2002 Restoration of p53 tumor suppressor pathway in human cervical carcinoma cells by sodium arsenite. sodium arsenite 81-96 tumor protein p53 Homo sapiens 15-18 12054599-5 2002 Two p53-responsive genes, p21(waf1/cip1) and mdm2, were induced after SA treatment. sodium arsenite 70-72 tumor protein p53 Homo sapiens 4-7 12054599-5 2002 Two p53-responsive genes, p21(waf1/cip1) and mdm2, were induced after SA treatment. sodium arsenite 70-72 cyclin dependent kinase inhibitor 1A Homo sapiens 26-39 12054599-6 2002 Furthermore, SA also reduced the expressions of Cdc25A and cyclin B, blocked cell cycle progression at G2/M phase, and induced apoptosis in SiHa cells. sodium arsenite 13-15 cell division cycle 25A Homo sapiens 48-54 12054599-7 2002 SA-induced apoptosis was greatly reduced by expression of a dominant-negative mutated p53. sodium arsenite 0-2 tumor protein p53 Homo sapiens 86-89 12054599-8 2002 In this study, we have first demonstrated that SA did repress E6 and E7 oncogenes, restore the p53 tumor suppressor pathway and induce apoptosis in SiHa cells. sodium arsenite 47-49 tumor protein p53 Homo sapiens 95-98 11893605-1 2002 In previous studies, the heat shock response, induced by hyperthermia or sodium arsenite, increased interleukin (IL)-6 production in intestinal mucosa and cultured human enterocytes. sodium arsenite 73-88 interleukin 6 Homo sapiens 100-118 11888201-8 2002 In contrast, sodium arsenite, a prototypical stress-type inducer of HO-1, led to down-regulation of the reporter gene down stream of MPRE. sodium arsenite 13-28 heme oxygenase 1 Gallus gallus 68-72 11832385-8 2002 Plasma levels of the anti-inflammatory cytokine interleukin (IL)-10 were increased in septic mice pretreated with sodium arsenite, and the protective effect of sodium arsenite on intestinal permeability in septic mice was reversed by treatment with anti-IL-10 antibody. sodium arsenite 114-129 interleukin 10 Mus musculus 48-67 11832385-8 2002 Plasma levels of the anti-inflammatory cytokine interleukin (IL)-10 were increased in septic mice pretreated with sodium arsenite, and the protective effect of sodium arsenite on intestinal permeability in septic mice was reversed by treatment with anti-IL-10 antibody. sodium arsenite 114-129 interleukin 10 Mus musculus 254-259 11832385-8 2002 Plasma levels of the anti-inflammatory cytokine interleukin (IL)-10 were increased in septic mice pretreated with sodium arsenite, and the protective effect of sodium arsenite on intestinal permeability in septic mice was reversed by treatment with anti-IL-10 antibody. sodium arsenite 160-175 interleukin 10 Mus musculus 48-67 11832385-8 2002 Plasma levels of the anti-inflammatory cytokine interleukin (IL)-10 were increased in septic mice pretreated with sodium arsenite, and the protective effect of sodium arsenite on intestinal permeability in septic mice was reversed by treatment with anti-IL-10 antibody. sodium arsenite 160-175 interleukin 10 Mus musculus 254-259 11855834-2 2002 We have previously shown that mrp1(-/-) cells are hypersensitive to sodium arsenite, sodium arsenate, and antimony potassium tartrate. sodium arsenite 68-83 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Mus musculus 30-34 11855834-3 2002 We now report that the retroviral vector-mediated overexpression of MRP1 and of the two subunits of gamma-GCS (heavy and light) resulted in higher intracellular glutathione levels and in a greater level of resistance to sodium arsenite and antimony potassium tartrate, compared to the overexpression of MRP1 and gamma-GCS heavy alone. sodium arsenite 220-235 ATP-binding cassette, sub-family B (MDR/TAP), member 1B Mus musculus 68-72 11914917-4 2002 In the mouse myocardial microvascular cell line, MyEnd, alphaB-crystallin as well as the heat shock proteins HSP 70i and HSP 25 display a low constitutive expression but can be significantly upregulated by sodium arsenite stress. sodium arsenite 206-221 crystallin, alpha B Mus musculus 56-73 11914917-4 2002 In the mouse myocardial microvascular cell line, MyEnd, alphaB-crystallin as well as the heat shock proteins HSP 70i and HSP 25 display a low constitutive expression but can be significantly upregulated by sodium arsenite stress. sodium arsenite 206-221 heat shock protein 1 Mus musculus 121-127 12509260-4 2002 Our results showed that Mre11 went through cell cycle-dependent phosphorylation upon sodium arsenite treatment and this post-translational modification required NBS1 but not ATM. sodium arsenite 85-100 MRE11 homolog, double strand break repair nuclease Homo sapiens 24-29 12509260-4 2002 Our results showed that Mre11 went through cell cycle-dependent phosphorylation upon sodium arsenite treatment and this post-translational modification required NBS1 but not ATM. sodium arsenite 85-100 nibrin Homo sapiens 161-165 11862762-3 2002 Chemical stress by sodium arsenite (arsenite) induces HSP27 coupled to the metabolic activity of the arachidonic acid cascade, and the HSP27 induction by arsenite is negatively regulated by activation of protein kinase C (PKC). sodium arsenite 19-34 heat shock protein family B (small) member 1 Homo sapiens 54-59 11750083-10 2002 The mdr1a/1b(-/-) mice accumulated more arsenic in the liver (15.3 vs. 5.2 microg/g), kidney (7.23 vs. 3.22 microg/g), small intestine (3.98 vs. 1.57 microg/g) and brain (0.45 vs. 0.17 microg/g), as compared with wild-type mice 24 h after sodium arsenite (14 mg/kg, s.c.) administration. sodium arsenite 239-254 ATP-binding cassette, sub-family B (MDR/TAP), member 1A Mus musculus 4-9 11706373-1 2002 The development toxicity of lead nitrate (25 mg/kg, SC), methylmercury chloride (12.5 mg/kg, PO), and sodium arsenite (6 mg/kg, SC) was assessed in CD1 mice following administration on gestation day 10 of these chemicals separately or in their binary and ternary combinations. sodium arsenite 102-117 CD1 antigen complex Mus musculus 148-151 11892989-5 2002 On the other hand, exposure to sodium arsenite or azetidine induced an increased accumulation of hsc70 mRNA, but did not lead to a concomitant increase in the level of U14 snoRNA. sodium arsenite 31-46 heat shock cognate 71 kDa protein Cricetulus griseus 97-102 11979425-0 2002 Acute sodium arsenite administration induces pulmonary CYP1A1 mRNA, protein and activity in the rat. sodium arsenite 6-21 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 55-61 11979426-0 2002 Acute sodium arsenite treatment induces Cyp2a5 but not Cyp1a1 in the C57Bl/6 mouse in a tissue (kidney) selective manner. sodium arsenite 6-21 cytochrome P450, family 2, subfamily a, polypeptide 5 Mus musculus 40-46 11807808-0 2002 Involvement of p38 mitogen-activated protein kinase in the cell growth inhibition by sodium arsenite. sodium arsenite 85-100 mitogen-activated protein kinase 14 Mus musculus 15-51 11807808-3 2002 Here, we examined possible roles of p38MAPK in the sodium arsenite-induced cell growth inhibition in NIH3T3 cells. sodium arsenite 51-66 mitogen-activated protein kinase 14 Mus musculus 36-43 11807808-4 2002 Sodium arsenite induced transient cell growth delay with marked activation of p38MAPK. sodium arsenite 0-15 mitogen-activated protein kinase 14 Mus musculus 78-85 11807808-7 2002 pRB was hypophosphorylated by sodium arsenite. sodium arsenite 30-45 RB transcriptional corepressor 1 Mus musculus 0-3 11807808-11 2002 These data demonstrate a possible link between the activation of p38MAPK and induction of p21(CIP1/WAF1), suggesting that the activation of p38MAPK is, at least in part, related to the cell growth inhibition by sodium arsenite. sodium arsenite 211-226 mitogen-activated protein kinase 14 Mus musculus 65-72 11807808-11 2002 These data demonstrate a possible link between the activation of p38MAPK and induction of p21(CIP1/WAF1), suggesting that the activation of p38MAPK is, at least in part, related to the cell growth inhibition by sodium arsenite. sodium arsenite 211-226 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 90-93 11807808-11 2002 These data demonstrate a possible link between the activation of p38MAPK and induction of p21(CIP1/WAF1), suggesting that the activation of p38MAPK is, at least in part, related to the cell growth inhibition by sodium arsenite. sodium arsenite 211-226 mitogen-activated protein kinase 14 Mus musculus 140-147 11835394-1 2002 Recent studies suggest that sodium arsenite downregulates NF-kappaB activity by inhibiting phosphorylation and subsequent degradation of IkappaBalpha. sodium arsenite 28-43 nuclear factor kappa B subunit 1 Homo sapiens 58-67 11835394-1 2002 Recent studies suggest that sodium arsenite downregulates NF-kappaB activity by inhibiting phosphorylation and subsequent degradation of IkappaBalpha. sodium arsenite 28-43 NFKB inhibitor alpha Homo sapiens 137-149 11835394-6 2002 Sodium arsenite blocked all of these responses to IL-1beta without inducing changes in heat shock factor activity or heat shock protein levels. sodium arsenite 0-15 interleukin 1 beta Homo sapiens 50-58 11835394-7 2002 Results from additional experiments showed that the protective effect of sodium arsenite on IkappaBalpha was not influenced by the oxygen radical scavenger catalase or by inhibitors of the MAP-kinase signaling pathway. sodium arsenite 73-88 NFKB inhibitor alpha Homo sapiens 92-104 11835394-8 2002 The present results suggest that sodium arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1beta-stimulated Caco-2 cells independent of the heat shock response. sodium arsenite 33-48 NFKB inhibitor alpha Homo sapiens 60-72 11835394-8 2002 The present results suggest that sodium arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1beta-stimulated Caco-2 cells independent of the heat shock response. sodium arsenite 33-48 nuclear factor kappa B subunit 1 Homo sapiens 86-95 11835394-8 2002 The present results suggest that sodium arsenite stabilizes IkappaBalpha and prevents NF-kappaB activation in IL-1beta-stimulated Caco-2 cells independent of the heat shock response. sodium arsenite 33-48 interleukin 1 beta Homo sapiens 110-118 11835394-9 2002 In addition, stabilization of IkappaBalpha by sodium arsenite does not require oxygen radical formation or activation of the MAP kinase signaling pathway. sodium arsenite 46-61 NFKB inhibitor alpha Homo sapiens 30-42 11740261-5 2001 Quercetin (30 microM), a suppressor of HSP, and sodium arsenite (100 microM), an inducer of HSP, were used to regulate the expression of HSP70 in PMNLs, and oxidative activity and apoptosis in these cells were measured. sodium arsenite 48-63 heat shock protein family A (Hsp70) member 4 Homo sapiens 137-142 11740261-8 2001 In the in vitro studies, administration of sodium arsenite enhanced the expression of HSP70, significantly increased oxidative activity, and inhibited apoptosis. sodium arsenite 43-58 heat shock protein family A (Hsp70) member 4 Homo sapiens 86-91 11825526-4 2001 (2) The expressions of p16 gene in the groups of sodium arsenite and sodium arsenate at the test were lower than that of the control group, especially in the groups of sodium arsenite. sodium arsenite 49-64 cyclin dependent kinase inhibitor 2A Homo sapiens 23-26 11825526-4 2001 (2) The expressions of p16 gene in the groups of sodium arsenite and sodium arsenate at the test were lower than that of the control group, especially in the groups of sodium arsenite. sodium arsenite 168-183 cyclin dependent kinase inhibitor 2A Homo sapiens 23-26 11574405-9 2001 Insulin and sodium arsenite, an activator of the stress-activated pathway, also stimulated PDX-1 movement from the nuclear periphery to the nucleoplasm. sodium arsenite 12-27 pancreatic and duodenal homeobox 1 Homo sapiens 91-96 11497330-2 2001 It was demonstrated that the HK-2 cells did not exhibit the classic heat-shock response when subjected to an acute physical (heat) or chemical stress (sodium arsenite or CdCl2). sodium arsenite 151-166 hexokinase 2 Homo sapiens 29-33 11446828-7 2001 Interestingly, sodium arsenite selectively activated p38 and JNK3, but not JNK1 or JNK2 in cerebellar neurons. sodium arsenite 15-30 mitogen activated protein kinase 14 Rattus norvegicus 53-56 11446828-7 2001 Interestingly, sodium arsenite selectively activated p38 and JNK3, but not JNK1 or JNK2 in cerebellar neurons. sodium arsenite 15-30 mitogen activated protein kinase 10 Rattus norvegicus 61-65 11408547-3 2001 Treatment of primary rat hepatocytes by sodium arsenite [As(III)], sodium arsenate and potassium antimony tartrate, but not cadmium chloride, was shown to markedly increase MRP2 mRNA and protein levels; As(III)-mediated induction was dose- and time-dependent and paralleled a strong increase in MRP2 amounts as assessed by Western blotting. sodium arsenite 40-55 ATP binding cassette subfamily C member 2 Rattus norvegicus 173-177 11408547-3 2001 Treatment of primary rat hepatocytes by sodium arsenite [As(III)], sodium arsenate and potassium antimony tartrate, but not cadmium chloride, was shown to markedly increase MRP2 mRNA and protein levels; As(III)-mediated induction was dose- and time-dependent and paralleled a strong increase in MRP2 amounts as assessed by Western blotting. sodium arsenite 40-55 ATP binding cassette subfamily C member 2 Rattus norvegicus 295-299 11368792-13 2001 Furthermore, treatment of cells with sodium arsenite increased levels of haem oxygenase concomitant with a marked decrease of spectrally detectable CYP2D6 and a rise in levels of ferritin, which sequesters free iron released from the destruction of haem. sodium arsenite 37-52 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 148-154 11368792-13 2001 Furthermore, treatment of cells with sodium arsenite increased levels of haem oxygenase concomitant with a marked decrease of spectrally detectable CYP2D6 and a rise in levels of ferritin, which sequesters free iron released from the destruction of haem. sodium arsenite 37-52 ferritin, mitochondrial Cricetulus griseus 179-187 11319142-5 2001 Using a sensitive reverse transcriptase-PCR assay we have investigated the expression of gadd153 and beta-actin in blastocyst-stage bovine embryos treated with MMS or sodium arsenite. sodium arsenite 167-182 beta actin Bos taurus 101-111 11148216-3 2001 Recent studies suggest that an important component of cell death following diverse stress stimuli (e.g. interleukin-3 withdrawal, sodium arsenite treatment, and peroxide treatment) is the activation of the double-stranded RNA-activable protein kinase, PKR, resulting in the inhibition of protein synthesis (Ito, T., Jagus, R., and May, W. S. (1994) Proc. sodium arsenite 130-145 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 252-255 11322385-2 2001 Our data show that chemical treatments including sodium arsenite and curcumin, induced significant synthesis of HSP70 and its mRNA. sodium arsenite 49-64 heat shock protein family A (Hsp70) member 4 Homo sapiens 112-117 11322385-5 2001 Phosphorylation and activation of extracellular signal-regulated proteins (ERK1/2) were detected in sodium arsenite-treated COLO205 and HT29 cells, and the free radical scavenger N-acetyl-L-cysteine (NAC) was able to inhibit this ERK1/2 activation and HSP70 gene expression. sodium arsenite 100-115 mitogen-activated protein kinase 3 Homo sapiens 75-81 11322385-5 2001 Phosphorylation and activation of extracellular signal-regulated proteins (ERK1/2) were detected in sodium arsenite-treated COLO205 and HT29 cells, and the free radical scavenger N-acetyl-L-cysteine (NAC) was able to inhibit this ERK1/2 activation and HSP70 gene expression. sodium arsenite 100-115 X-linked Kx blood group Homo sapiens 200-203 11322385-5 2001 Phosphorylation and activation of extracellular signal-regulated proteins (ERK1/2) were detected in sodium arsenite-treated COLO205 and HT29 cells, and the free radical scavenger N-acetyl-L-cysteine (NAC) was able to inhibit this ERK1/2 activation and HSP70 gene expression. sodium arsenite 100-115 mitogen-activated protein kinase 3 Homo sapiens 230-236 11322385-5 2001 Phosphorylation and activation of extracellular signal-regulated proteins (ERK1/2) were detected in sodium arsenite-treated COLO205 and HT29 cells, and the free radical scavenger N-acetyl-L-cysteine (NAC) was able to inhibit this ERK1/2 activation and HSP70 gene expression. sodium arsenite 100-115 heat shock protein family A (Hsp70) member 4 Homo sapiens 252-257 11322385-6 2001 MAPK blockade by the specific MEK1 inhibitor (PD98059) decreased the ability of sodium arsenite to increase HSP70 gene expression in a dose-dependent manner along with dephosphorylation of ERK1/2 proteins. sodium arsenite 80-95 mitogen-activated protein kinase kinase 1 Homo sapiens 30-34 11322385-6 2001 MAPK blockade by the specific MEK1 inhibitor (PD98059) decreased the ability of sodium arsenite to increase HSP70 gene expression in a dose-dependent manner along with dephosphorylation of ERK1/2 proteins. sodium arsenite 80-95 heat shock protein family A (Hsp70) member 4 Homo sapiens 108-113 11322385-6 2001 MAPK blockade by the specific MEK1 inhibitor (PD98059) decreased the ability of sodium arsenite to increase HSP70 gene expression in a dose-dependent manner along with dephosphorylation of ERK1/2 proteins. sodium arsenite 80-95 mitogen-activated protein kinase 3 Homo sapiens 189-195 11322385-9 2001 These results indicated that the ERK signaling pathway can participate in HSP70 gene expression induced by the prooxidant sodium arsenite, but not by the antioxidant curcumin. sodium arsenite 122-137 mitogen-activated protein kinase 3 Homo sapiens 33-36 11322385-9 2001 These results indicated that the ERK signaling pathway can participate in HSP70 gene expression induced by the prooxidant sodium arsenite, but not by the antioxidant curcumin. sodium arsenite 122-137 heat shock protein family A (Hsp70) member 4 Homo sapiens 74-79 11160250-4 2001 SA inhibited LPS-induced NF-kappaB activation by preventing loss of IkappaB-alpha and -beta. sodium arsenite 0-2 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 68-91 11160250-5 2001 Furthermore, SA blocked phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2), but not phosphorylation of p38 and c-Jun N-terminal kinase. sodium arsenite 13-15 mitogen-activated protein kinase 3 Mus musculus 43-84 11160250-5 2001 Furthermore, SA blocked phosphorylation of extracellular signal-regulated kinase 1/2 (Erk1/2), but not phosphorylation of p38 and c-Jun N-terminal kinase. sodium arsenite 13-15 mitogen-activated protein kinase 3 Mus musculus 86-92 11160250-6 2001 SA treatment resulted in the disappearance of Raf-1, suggesting that it might cause the inhibition of the Erk1/2 mitogen-activated protein (MAP) kinase pathway. sodium arsenite 0-2 v-raf-leukemia viral oncogene 1 Mus musculus 46-51 11160250-6 2001 SA treatment resulted in the disappearance of Raf-1, suggesting that it might cause the inhibition of the Erk1/2 mitogen-activated protein (MAP) kinase pathway. sodium arsenite 0-2 mitogen-activated protein kinase 3 Mus musculus 106-112 11160250-9 2001 Taken together, these results indicate that the inhibitory action of SA on NO production in LPS-stimulated macrophages might be due to abrogation of inducible NO synthase induction, and it might be closely related to inactivation of the NF-kappaB and Erk1/2 MAP kinase pathways through loss of Raf-1. sodium arsenite 69-71 nitric oxide synthase 2, inducible Mus musculus 149-170 11160250-9 2001 Taken together, these results indicate that the inhibitory action of SA on NO production in LPS-stimulated macrophages might be due to abrogation of inducible NO synthase induction, and it might be closely related to inactivation of the NF-kappaB and Erk1/2 MAP kinase pathways through loss of Raf-1. sodium arsenite 69-71 mitogen-activated protein kinase 3 Mus musculus 251-257 11160250-9 2001 Taken together, these results indicate that the inhibitory action of SA on NO production in LPS-stimulated macrophages might be due to abrogation of inducible NO synthase induction, and it might be closely related to inactivation of the NF-kappaB and Erk1/2 MAP kinase pathways through loss of Raf-1. sodium arsenite 69-71 v-raf-leukemia viral oncogene 1 Mus musculus 294-299 11423728-2 2001 This study was performed to evaluate the effect of heat-shock protein (HSP)70 induction with sodium arsenite (SA) on ischemia/reperfusion (I/R) or cyclosporin A (CsA)-induced injuries in rat kidney. sodium arsenite 93-108 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 51-77 11423728-2 2001 This study was performed to evaluate the effect of heat-shock protein (HSP)70 induction with sodium arsenite (SA) on ischemia/reperfusion (I/R) or cyclosporin A (CsA)-induced injuries in rat kidney. sodium arsenite 110-112 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 51-77 11423728-8 2001 Induction of HSP70 with SA improved both renal function and the histopathology score as compared to the group without HSP70 induction. sodium arsenite 24-26 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 13-18 11423728-11 2001 In conclusion, SA pretreatment prevents subsequent I/R or CsA-induced injuries in the rat kidney, and this renoprotective effect appears to be mediated by induction of HSP70. sodium arsenite 15-17 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 168-173 11746514-2 2001 In the present study, we examined the effects of midazolam, an intravenous anesthetic, on the HSP27 induction stimulated by vasopressin, heat, or sodium arsenite (arsenite) in A10 cells. sodium arsenite 146-161 heat shock protein family B (small) member 1 Homo sapiens 94-99 11198361-0 2001 Effect of sodium arsenite on iNOS expression and vascular hyporeactivity associated with cecal ligation and puncture in the rat. sodium arsenite 10-25 nitric oxide synthase 2 Rattus norvegicus 29-33 11198361-6 2001 Pretreatment of the rats with SA resulted in reversal of CLP-induced vascular hyporeactivity in vivo and ex vivo, and inhibition of iNOS expression after 22 h. SA pretreatment improved 7-day survival after CLP from 18.2% to 70% (P < 0.005). sodium arsenite 160-162 nitric oxide synthase 2 Rattus norvegicus 132-136 10986282-3 2000 Here, we report that the expression of mitogen-activated protein (MAP) kinase/extracellular signal-regulated kinase kinase kinase 1 (MEKK1), transforming growth factor-beta-activated kinase (TAK1), and apoptosis signal-regulating kinase (ASK1) in HepG2 cells activated the ARE reporter gene, whereas the expression of their dominant-negative mutants impaired ARE activation by the chemicals sodium arsenite and mercury chloride. sodium arsenite 391-406 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 238-242 11078701-8 2000 On the other hand, sodium arsenite, a known activator of the stress response pathway, induced HO-1 mRNA expression but lacked a promoting effect on TG production. sodium arsenite 19-34 heme oxygenase 1 Homo sapiens 94-98 11099391-6 2000 Hyperthermia and sodium arsenite increased hsp72 levels in the intestinal mucosa. sodium arsenite 17-32 heat shock protein 1A Mus musculus 43-48 10952983-3 2000 A dominant-negative allele of Rac1 (Rac1N17) inhibits the hypoxia/reoxygenation and sodium arsenite-induced transcriptional activity of HSF-1 and the transcription of heat shock protein 70. sodium arsenite 84-99 Rac family small GTPase 1 Homo sapiens 30-34 10952983-3 2000 A dominant-negative allele of Rac1 (Rac1N17) inhibits the hypoxia/reoxygenation and sodium arsenite-induced transcriptional activity of HSF-1 and the transcription of heat shock protein 70. sodium arsenite 84-99 heat shock transcription factor 1 Homo sapiens 136-141 11042089-6 2000 These results indicate the induction of CYP1A4 and 1A5 is inhibited by sodium arsenite at the level of transcription, suggesting that the Ah receptor complex may be involved. sodium arsenite 71-86 cytochrome P450 1A4 Gallus gallus 40-46 11035063-4 2000 We demonstrated that NaAsO(2)-induced caspase activation is dependent on curcumin-sensitive c-Jun amino-terminal kinase and barely dependent on SB203580-sensitive p38 kinase or PD98059-sensitive extracellular signal-regulated kinase. sodium arsenite 21-29 jun proto-oncogene Mus musculus 92-97 11035063-8 2000 beta cyclodextrin, which sequestrates cholesterol from the membrane rafts, inhibited NaAsO(2)-induced activation of protein tyrosine kinases and MAP family kinases, degradation of PARP, and production of superoxide. sodium arsenite 85-93 poly (ADP-ribose) polymerase family, member 1 Mus musculus 180-184 11035063-10 2000 These results suggest that a membrane raft integrity-dependent cell surface event is a prerequisite for NaAsO(2)-induced protein tyrosine kinase/c-Jun amino-terminal kinase activation, superoxide production, and downstream caspase activation. sodium arsenite 104-112 jun proto-oncogene Mus musculus 145-150 10964950-3 2000 Here we investigated the role of JNK and p38 in cortical neuron apoptosis caused by sodium arsenite treatment. sodium arsenite 84-99 mitogen-activated protein kinase 8 Homo sapiens 33-36 10964950-5 2000 Treatment of cortical neurons with sodium arsenite activated p38 and JNK3 but not JNK1 or JNK2. sodium arsenite 35-50 mitogen-activated protein kinase 14 Homo sapiens 61-64 10964950-5 2000 Treatment of cortical neurons with sodium arsenite activated p38 and JNK3 but not JNK1 or JNK2. sodium arsenite 35-50 mitogen-activated protein kinase 10 Homo sapiens 69-73 10906077-6 2000 Treatments of isolated tubules with either sodium arsenite, known to induce HO-1, or hematin, an HO substrate, resulted in 4.4- and 1.8-fold, respectively, increases in cGMP levels. sodium arsenite 43-58 heme oxygenase 1 Homo sapiens 76-80 10942197-1 2000 Previously, chick heme oxygenase-1 (cHO-1) gene was cloned by us and two regions important for induction by sodium arsenite were identified. sodium arsenite 108-123 heme oxygenase 1 Gallus gallus 18-34 10942197-4 2000 DNA binding studies and site-directed mutagenesis studies indicated that both the AP-1 and MRE/cMyc elements are important for the sodium arsenite induction, while cobalt chloride induction involves only the AP-1 element. sodium arsenite 131-146 v-myc avian myelocytomatosis viral oncogene homolog Gallus gallus 95-99 10942197-6 2000 Site-directed mutagenesis studies showed that, to completely abolish sodium arsenite induction, both the AP-1 and MRE/cMyc elements must be mutated; mutation of either element alone resulted in only a partial effect. sodium arsenite 69-84 v-myc avian myelocytomatosis viral oncogene homolog Gallus gallus 118-122 10802388-4 2000 Similar results were obtained when the cells were subjected to a classic chemical stress of exposure to 100 microM sodium arsenite for 4 h. Acute exposure of HPT cells to 53.4 microM CdCl(2) for 4 h also resulted in an increase in hsp 60 mRNA and protein following removal of the metal. sodium arsenite 115-130 heat shock protein family D (Hsp60) member 1 Homo sapiens 231-237 10799907-4 2000 Both HS and sodium arsenite treatment increased HSP70 expression time dependently at mRNA and protein levels. sodium arsenite 12-27 heat shock protein family A (Hsp70) member 4 Homo sapiens 48-53 10792534-3 2000 In laboratory strains of Saccharomyces cerevisiae, the heat shock protein, Hsp104, plays a major role in the acquisition of tolerance to a variety of stresses such as heat, ethanol and sodium arsenite, and as such acts as an excellent stress indicator. sodium arsenite 185-200 chaperone ATPase HSP104 Saccharomyces cerevisiae S288C 75-81 10841042-1 2000 In a previous study, we have demonstrated that sodium arsenite (arsenite) as chemical stress stimulates heat shock protein 27 (HSP27) induction and arachidonic acid release in osteoblast-like MC3T3-E1 cells, and that the response of HSP27 induction is coupled with metabolic activity of the arachidonic acid cascade. sodium arsenite 47-62 heat shock protein 1 Mus musculus 104-125 10841042-1 2000 In a previous study, we have demonstrated that sodium arsenite (arsenite) as chemical stress stimulates heat shock protein 27 (HSP27) induction and arachidonic acid release in osteoblast-like MC3T3-E1 cells, and that the response of HSP27 induction is coupled with metabolic activity of the arachidonic acid cascade. sodium arsenite 47-62 heat shock protein 1 Mus musculus 127-132 10841042-1 2000 In a previous study, we have demonstrated that sodium arsenite (arsenite) as chemical stress stimulates heat shock protein 27 (HSP27) induction and arachidonic acid release in osteoblast-like MC3T3-E1 cells, and that the response of HSP27 induction is coupled with metabolic activity of the arachidonic acid cascade. sodium arsenite 47-62 heat shock protein 1 Mus musculus 233-238 10652248-2 2000 Previously, we showed that the cell death induced in day 9 mouse embryos by three teratogens, hyperthermia (HS), 4-hydroperoxycyclophosphamide (4-CP), and sodium arsenite (As), is apoptotic in nature involving the activation of caspase-3, cleavage of poly(ADP-ribose) polymerase (PARP), and DNA fragmentation. sodium arsenite 155-170 caspase 3 Mus musculus 228-237 10652248-2 2000 Previously, we showed that the cell death induced in day 9 mouse embryos by three teratogens, hyperthermia (HS), 4-hydroperoxycyclophosphamide (4-CP), and sodium arsenite (As), is apoptotic in nature involving the activation of caspase-3, cleavage of poly(ADP-ribose) polymerase (PARP), and DNA fragmentation. sodium arsenite 155-170 poly (ADP-ribose) polymerase family, member 1 Mus musculus 251-278 10652248-2 2000 Previously, we showed that the cell death induced in day 9 mouse embryos by three teratogens, hyperthermia (HS), 4-hydroperoxycyclophosphamide (4-CP), and sodium arsenite (As), is apoptotic in nature involving the activation of caspase-3, cleavage of poly(ADP-ribose) polymerase (PARP), and DNA fragmentation. sodium arsenite 155-170 poly (ADP-ribose) polymerase family, member 1 Mus musculus 280-284 10701838-7 2000 Treatment of tailbud embryos with either sodium arsenite or zinc chloride induced a tissue-specific enrichment of hsp70 mRNA in the lens placode and somitic region. sodium arsenite 41-56 heat shock protein family A (Hsp70) member 1 like S homeolog Xenopus laevis 114-119 10774621-9 2000 Sodium arsenite-injected mice showed HSP-70 induction in the ileum that increased in a time-dependent manner with peak expression 12 h post-injection. sodium arsenite 0-15 heat shock protein 1B Mus musculus 37-43 10774621-11 2000 These data show that sodium arsenite induced HSP-70 expression in the small intestine. sodium arsenite 21-36 heat shock protein 1B Mus musculus 45-51 10600159-2 1999 Induction of heme oxygenase-1 can be caused by numerous factors, including heme, other metalloporphyrins, transition metal ions, heat shock, ultraviolet light, phorbol esters, sodium arsenite, and phenylarsine oxide (PAO). sodium arsenite 176-191 heme oxygenase 1 Gallus gallus 13-29 10600159-4 1999 Using heme oxygenase-1 promoter/reporter gene constructs, we have previously reported that the sodium arsenite-mediated induction of heme oxygenase-1 in chick embryo liver cells and chicken hepatoma (LMH) cells involves an AP-1 element. sodium arsenite 95-110 heme oxygenase 1 Gallus gallus 6-22 10600159-4 1999 Using heme oxygenase-1 promoter/reporter gene constructs, we have previously reported that the sodium arsenite-mediated induction of heme oxygenase-1 in chick embryo liver cells and chicken hepatoma (LMH) cells involves an AP-1 element. sodium arsenite 95-110 heme oxygenase 1 Gallus gallus 133-149 10656165-3 1999 A significant reduction in plasma levels of LH, FSH and estrogen along with significant diminution in the activities of ovarian delta 5-3 beta-HSD and 17 beta-HSD were observed following sodium arsenite treatment for 28 days. sodium arsenite 187-202 hydroxysteroid (17-beta) dehydrogenase 3 Rattus norvegicus 151-162 10542372-3 1999 When mouse blastocysts were exposed to the alkylating agent MMS, the metabolic inhibitor sodium arsenite or an inhibitor of protein glycosylation tunicamycin, levels of the CHOP-10 mRNA were increased by two- to threefold relative to the mRNA for beta-actin. sodium arsenite 89-104 DNA-damage inducible transcript 3 Mus musculus 173-180 10542372-3 1999 When mouse blastocysts were exposed to the alkylating agent MMS, the metabolic inhibitor sodium arsenite or an inhibitor of protein glycosylation tunicamycin, levels of the CHOP-10 mRNA were increased by two- to threefold relative to the mRNA for beta-actin. sodium arsenite 89-104 actin, beta Mus musculus 247-257 10542372-6 1999 When F9 embryonal carcinoma cells were treated with MMS or sodium arsenite, CHOP-10 expression was induced by fourfold within 4 hr of treatment. sodium arsenite 59-74 DNA-damage inducible transcript 3 Mus musculus 76-83 10521501-3 1999 We compared intracellular signaling mediating IL-8 gene expression in bronchial epithelial cells cultured in vitro and exposed to two inducers of cellular stress, sodium arsenite (As(III)), and vanadyl sulfate (V(IV)). sodium arsenite 163-178 C-X-C motif chemokine ligand 8 Homo sapiens 46-50 10464319-4 1999 The pro-oxidants sodium arsenite, cadmium chloride, and hydrogen peroxide activated JNK1 with slow kinetics, whereas UV-B potentiated the activity of JNK1 rapidly. sodium arsenite 17-32 mitogen-activated protein kinase 8 Homo sapiens 84-88 10466990-6 1999 Some vessels were treated with sodium arsenite (positive control, known to induce HSP70 expression). sodium arsenite 31-46 heat shock protein family A (Hsp70) member 4 Homo sapiens 82-87 10464058-6 1999 Treatment of the cells with sodium arsenite or subjecting them to hyperthermia induced the expression of hsp72. sodium arsenite 28-43 heat shock protein family A (Hsp70) member 1A Homo sapiens 105-110 10464058-7 1999 The IL-1beta-induced expression of C3 mRNA and C3 production were down-regulated by hyperthermia and sodium arsenite in a dose-dependent fashion. sodium arsenite 101-116 interleukin 1 beta Homo sapiens 4-12 10464058-8 1999 The results suggest that the stress response induced by hyperthermia or sodium arsenite decreases IL-1beta-induced C3 production in human enterocytes. sodium arsenite 72-87 interleukin 1 beta Homo sapiens 98-106 10445755-3 1999 In both rodent and human fibroblasts, DNA synthesis was found to be stimulated in cells exposed to a transient, sub-lethal concentration of sodium arsenite followed by stimulation with known RTK pathway activators. sodium arsenite 140-155 ret proto-oncogene Homo sapiens 191-194 11721386-8 1999 CONCLUSION: Sodium arsenite selectively induced apoptosis of G2 + M phase NB4 cells, accompanied by upregulation of cyclin B1. sodium arsenite 12-27 cyclin B1 Homo sapiens 116-125 10329507-2 1999 Here we investigated the effect of sodium arsenite on induction of CYP2B, CYP1A, and CYP3A in primary cultures of rat hepatocytes. sodium arsenite 35-50 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 85-90 10329507-8 1999 With dexamethasone (DEX) as inducer, 5 microM sodium arsenite caused a 50% decrease in immunoreactive CYP3A and a 30% decrease in CYP3A23 mRNA. sodium arsenite 46-61 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 102-107 10329507-8 1999 With dexamethasone (DEX) as inducer, 5 microM sodium arsenite caused a 50% decrease in immunoreactive CYP3A and a 30% decrease in CYP3A23 mRNA. sodium arsenite 46-61 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 130-137 10319276-0 1999 Sodium arsenite reduces proliferation of human activated T-cells by inhibition of the secretion of interleukin-2. sodium arsenite 0-15 interleukin 2 Homo sapiens 99-112 10319276-9 1999 These alterations suggest that due to sodium arsenite effects on cytoskeleton, the intracellular secretion of proteins is affected, including the one of IL-2, leading to an impaired proliferation of the T cells when stimulated with PHA. sodium arsenite 38-53 interleukin 2 Homo sapiens 153-157 10216529-2 1999 METHODS: Hsp-73 expression was induced in rat small intestine with use of sodium arsenite injected (6 mg/kg) through a catheter cannulated into the left common carotid artery 24 hours before ischemia (group 1). sodium arsenite 74-89 selenoprotein K Rattus norvegicus 9-12 10221768-3 1999 The cellular stress agents sodium arsenite and hyperosmotic sorbitol significantly stimulated p38 MAPK activity, as did the tyrosine phosphatase inhibitor sodium pervanadate and the serine/threonine phosphatase inhibitor okadaic acid. sodium arsenite 27-42 mitogen activated protein kinase 14 Rattus norvegicus 94-97 9927172-3 1999 hsp70 functioned well when induced by heat shock and was also induced to a lesser extent by chemicals such as sodium arsenite. sodium arsenite 110-125 heat shock protein 1B Mus musculus 0-5 10197422-5 1999 The cell-free extract of Clostridium sporogenes had debrominating activity in the presence of both FMN and NADH (or NADPH), and this activity was inhibited by sodium arsenite and potassium cyanide. sodium arsenite 159-174 2,4-dienoyl-CoA reductase 1 Homo sapiens 116-121 9837857-1 1998 Heme oxygenase 1 (HO-1), a stress response protein, is highly induced in response to various agents causing oxidative stress including ultraviolet irradiation, sodium arsenite, hyperoxia, and glutathione depletors. sodium arsenite 160-175 heme oxygenase 1 Rattus norvegicus 0-16 9837857-1 1998 Heme oxygenase 1 (HO-1), a stress response protein, is highly induced in response to various agents causing oxidative stress including ultraviolet irradiation, sodium arsenite, hyperoxia, and glutathione depletors. sodium arsenite 160-175 heme oxygenase 1 Rattus norvegicus 18-22 9820195-7 1998 Limiting expression of Hsp70-1/3 with 5 microM A070-1/3 also heightened embryo sensitivity to arsenic, resulting in less than 5% in vitro development to blastocyst in the presence of the subtoxic dose of 0.4 microM sodium arsenite. sodium arsenite 215-230 heat shock protein 1A Mus musculus 23-32 9837746-1 1998 We previously reported that PKN, a fatty acid-activated serine/threonine protein kinase, translocates from the cytosol to the nucleus by stresses such as heat shock, sodium arsenite, and serum starvation. sodium arsenite 166-181 protein kinase N1 Homo sapiens 28-31 9747510-7 1998 In addition to hyperoxia, sodium arsenite (NaAsO2), cadmium chloride (CdCl(2)) and hydrogen peroxide (H2O2), which are reactive oxygen intermediates (ROI) generators, increased the HO-1 mRNA level by 11-, 22- and 2.5-fold, respectively. sodium arsenite 26-41 heme oxygenase 1 Homo sapiens 181-185 9747510-7 1998 In addition to hyperoxia, sodium arsenite (NaAsO2), cadmium chloride (CdCl(2)) and hydrogen peroxide (H2O2), which are reactive oxygen intermediates (ROI) generators, increased the HO-1 mRNA level by 11-, 22- and 2.5-fold, respectively. sodium arsenite 43-49 heme oxygenase 1 Homo sapiens 181-185 9722676-0 1998 Involvement of the tyrosine phosphorylation pathway in induction of human heme oxygenase-1 by hemin, sodium arsenite, and cadmium chloride. sodium arsenite 101-116 heme oxygenase 1 Homo sapiens 74-90 9722676-1 1998 The effect of a tyrosine kinase inhibitor, herbimycin A, on the induction of heme oxygenase-1 (HO-1) mRNA in HeLa cells upon exposure to hemin, sodium arsenite and cadmium chloride was examined. sodium arsenite 144-159 heme oxygenase 1 Homo sapiens 77-93 9722676-1 1998 The effect of a tyrosine kinase inhibitor, herbimycin A, on the induction of heme oxygenase-1 (HO-1) mRNA in HeLa cells upon exposure to hemin, sodium arsenite and cadmium chloride was examined. sodium arsenite 144-159 heme oxygenase 1 Homo sapiens 95-99 9712902-6 1998 In this regard, we show that treatment with sodium arsenite, a known activator of p38 MAP kinases, also stimulates expression from the PEPCK promoter. sodium arsenite 44-59 mitogen-activated protein kinase 14 Homo sapiens 82-85 9712902-6 1998 In this regard, we show that treatment with sodium arsenite, a known activator of p38 MAP kinases, also stimulates expression from the PEPCK promoter. sodium arsenite 44-59 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 135-140 9671310-1 1998 Pretreatment of cells with 0.5 mM sodium arsenite (but not other activators of stress-activated MAP kinase cascades) prevents the activation of p21Ras and strongly suppresses the activation of c-Raf and the MAP kinase cascade by a variety of growth factors. sodium arsenite 34-49 HRas proto-oncogene, GTPase Homo sapiens 144-150 9671310-1 1998 Pretreatment of cells with 0.5 mM sodium arsenite (but not other activators of stress-activated MAP kinase cascades) prevents the activation of p21Ras and strongly suppresses the activation of c-Raf and the MAP kinase cascade by a variety of growth factors. sodium arsenite 34-49 Raf-1 proto-oncogene, serine/threonine kinase Homo sapiens 193-198 10200514-3 1998 We show that three teratogens, hyperthermia, cyclophosphamide and sodium arsenite induce an increase in cell death in day 9.0 mouse embryos with concurrent induction of DNA fragmentation, activation of caspase-3 and the cleavage of poly (ADP-ribose) polymerase (PARP). sodium arsenite 66-81 caspase 3 Mus musculus 202-211 10200514-3 1998 We show that three teratogens, hyperthermia, cyclophosphamide and sodium arsenite induce an increase in cell death in day 9.0 mouse embryos with concurrent induction of DNA fragmentation, activation of caspase-3 and the cleavage of poly (ADP-ribose) polymerase (PARP). sodium arsenite 66-81 poly (ADP-ribose) polymerase family, member 1 Mus musculus 232-260 10200514-3 1998 We show that three teratogens, hyperthermia, cyclophosphamide and sodium arsenite induce an increase in cell death in day 9.0 mouse embryos with concurrent induction of DNA fragmentation, activation of caspase-3 and the cleavage of poly (ADP-ribose) polymerase (PARP). sodium arsenite 66-81 poly (ADP-ribose) polymerase family, member 1 Mus musculus 262-266 9671412-4 1998 Here we report that in NIH3T3 cells, egr-1 is induced by various stress treatments such as heat shock, sodium arsenite, ultraviolet (U.V.) sodium arsenite 103-118 early growth response 1 Mus musculus 37-42 9653069-1 1998 In earlier studies, treatment with sodium arsenite was shown to decrease total hepatic CYP in rats. sodium arsenite 35-50 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 87-90 9653069-5 1998 Near maximal decreases were observed in these forms of CYP at a concentration of 2.5 microM sodium arsenite. sodium arsenite 92-107 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 55-58 9535875-0 1998 Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. sodium arsenite 13-28 heme oxygenase 1 Gallus gallus 51-67 9535875-4 1998 We identified a heme oxygenase-1 promoter-driven luciferase reporter construct that was highly and reproducibly expressed in response to sodium arsenite treatment. sodium arsenite 137-152 heme oxygenase 1 Gallus gallus 16-32 9535875-6 1998 In LMH cells, sodium arsenite, cadmium, and heat shock, but not heme, induced activity of the MAP kinases extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. sodium arsenite 14-29 adapter molecule crk Gallus gallus 179-182 9604300-11 1998 With liver slices produced by both tissue slicers 50 microM sodium arsenite produced a greater induction of heat shock protein 70 levels in slices cultured for 24 h in a high oxygen than in an air atmosphere. sodium arsenite 60-75 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 108-129 10099789-5 1998 Furthermore, the optimal temperature of BShsp induction, temporal pattern of synthesis, and induction of BShsps by other stressors such as herbimycin A and sodium arsenite were similar to those reported for the acidic hsp30 family. sodium arsenite 156-171 heat shock protein 30E L homeolog Xenopus laevis 218-223 9403530-8 1997 Induction of HSP 70 in T-cell clones with sodium arsenite had a similar protective effect against radiation-induced apoptosis. sodium arsenite 42-57 heat shock protein 1B Mus musculus 13-19 9434882-0 1997 Induction of p53 protein expression by sodium arsenite. sodium arsenite 39-54 tumor protein p53 Homo sapiens 13-16 9434882-3 1997 Intrigued by these effects and based on the role of p53 on cell proliferation, we tested different concentrations of sodium arsenite for their ability to induce the expression of tumor suppressor gene p53 in different cell lines (HeLa, C-33A. sodium arsenite 117-132 tumor protein p53 Homo sapiens 52-55 9434882-3 1997 Intrigued by these effects and based on the role of p53 on cell proliferation, we tested different concentrations of sodium arsenite for their ability to induce the expression of tumor suppressor gene p53 in different cell lines (HeLa, C-33A. sodium arsenite 117-132 tumor protein p53 Homo sapiens 201-204 9434882-6 1997 Immunoblots showed an increased expression of p53 gene with 1 microM sodium arsenite in Jurkat cells and 10 microM sodium arsenite in HeLa and LCL-EBV cells. sodium arsenite 69-84 tumor protein p53 Homo sapiens 46-49 9434882-6 1997 Immunoblots showed an increased expression of p53 gene with 1 microM sodium arsenite in Jurkat cells and 10 microM sodium arsenite in HeLa and LCL-EBV cells. sodium arsenite 115-130 tumor protein p53 Homo sapiens 46-49 9299480-0 1997 p70 S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: roles for phosphatidylinositol 3-kinase and p38 MAP kinase. sodium arsenite 30-45 ribosomal protein S6 kinase B1 Rattus norvegicus 0-13 9276477-6 1997 We show here that expression of the NTH1 gene and its product, neutral trehalase (Nthlp), are also induced by other stressors such as H2O2, CuSO4, NaAsO2, and cycloheximide (CHX). sodium arsenite 147-153 alpha,alpha-trehalase NTH1 Saccharomyces cerevisiae S288C 36-40 9288946-1 1997 Sodium arsenite and osmotic shock both stimulated stress-activated protein kinase-2 (SAPK2, also termed RK, p38, CSBP and Mxi2) and its downstream target mitogen-activated protein kinase (MAP kinase)-activated protein kinase-2 (MAPKAP-K2) in bovine adrenal chromaffin and rat PC12 cells. sodium arsenite 0-15 mitogen-activated protein kinase 14 Bos taurus 108-111 9288946-1 1997 Sodium arsenite and osmotic shock both stimulated stress-activated protein kinase-2 (SAPK2, also termed RK, p38, CSBP and Mxi2) and its downstream target mitogen-activated protein kinase (MAP kinase)-activated protein kinase-2 (MAPKAP-K2) in bovine adrenal chromaffin and rat PC12 cells. sodium arsenite 0-15 MAPK activated protein kinase 2 Bos taurus 154-226 9288946-1 1997 Sodium arsenite and osmotic shock both stimulated stress-activated protein kinase-2 (SAPK2, also termed RK, p38, CSBP and Mxi2) and its downstream target mitogen-activated protein kinase (MAP kinase)-activated protein kinase-2 (MAPKAP-K2) in bovine adrenal chromaffin and rat PC12 cells. sodium arsenite 0-15 MAPK activated protein kinase 2 Bos taurus 228-237 9219564-3 1997 We found that exposure of human lung adenocarcinoma A549 cells to sodium arsenite (0.08-2 microM) or sodium arsenate (30-300 microM), but not dimethylarsenic acid (2-2000 microM), produced significant dose-responsive hypermethylation within a 341-base pair fragment of the promoter of p53. sodium arsenite 66-81 tumor protein p53 Homo sapiens 285-288 9219571-8 1997 The effect of treatment with sodium arsenite on PARP activity was assessed as follows: Molt-3 cells (a human T-cell lymphoma-derived cell line) in culture were treated for 24 h with concentrations of sodium arsenite ranging from 2.5 up to 25 microM. sodium arsenite 29-44 poly(ADP-ribose) polymerase 1 Homo sapiens 48-52 9176145-5 1997 Sodium arsenite at 80-320 microM, which induced heat shock protein 72 (HSP72) expression and reactive oxygen intermediate (ROI) generation in ECs, resulted in EC apoptosis. sodium arsenite 0-15 heat shock protein family A (Hsp70) member 1A Homo sapiens 48-69 9176145-5 1997 Sodium arsenite at 80-320 microM, which induced heat shock protein 72 (HSP72) expression and reactive oxygen intermediate (ROI) generation in ECs, resulted in EC apoptosis. sodium arsenite 0-15 heat shock protein family A (Hsp70) member 1A Homo sapiens 71-76 9176145-7 1997 Heat shock alone (42 degrees C, 45 min) or sodium arsenite (40 microM) alone, each of which induced HSP72 expression, did not result in EC apoptosis. sodium arsenite 43-58 heat shock protein family A (Hsp70) member 1A Homo sapiens 100-105 9176145-8 1997 However, the combination of TNF-alpha with heat shock or 40 microM sodium arsenite led to EC apoptosis as HSP72 expression and ROI were induced. sodium arsenite 67-82 heat shock protein family A (Hsp70) member 1A Homo sapiens 106-111 8971075-3 1997 We now show that oxidative and chemical stress (hydrogen peroxide and sodium meta-arsenite, respectively) also produce a dominant inhibitory effect, both on the endogenous PEPCK gene and on a stably transfected PEPCK-chloramphenicol acetyl transferase (CAT) fusion gene. sodium arsenite 70-90 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 172-177 8971075-3 1997 We now show that oxidative and chemical stress (hydrogen peroxide and sodium meta-arsenite, respectively) also produce a dominant inhibitory effect, both on the endogenous PEPCK gene and on a stably transfected PEPCK-chloramphenicol acetyl transferase (CAT) fusion gene. sodium arsenite 70-90 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 211-216 8971075-5 1997 Thus, the mechanism(s) used by hydrogen peroxide and sodium meta-arsenite to regulate PEPCK gene expression are PI 3-kinase independent. sodium arsenite 53-73 phosphoenolpyruvate carboxykinase 2, mitochondrial Homo sapiens 86-91 8971075-5 1997 Thus, the mechanism(s) used by hydrogen peroxide and sodium meta-arsenite to regulate PEPCK gene expression are PI 3-kinase independent. sodium arsenite 53-73 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Homo sapiens 112-123 8971075-7 1997 The reactivating kinase (RK, also known as p38 mitogen activated protein kinase) is induced by insulin, hydrogen peroxide, or sodium meta-arsenite in hepatoma cells, and these effects are blocked by SB203580, a selective inhibitor of RK. sodium arsenite 126-146 mitogen-activated protein kinase 14 Homo sapiens 43-46 9261921-1 1997 In a previous study, we found that sodium arsenite increased hepatic ornithine decarboxylase (ODC) activity and hepatic heme oxygenase (HO) activity, but did not cause any DNA damage in adult female rat liver or lung, suggesting that arsenite may be a promoter of carcinogenesis. sodium arsenite 35-50 ornithine decarboxylase 1 Rattus norvegicus 69-92 9261921-1 1997 In a previous study, we found that sodium arsenite increased hepatic ornithine decarboxylase (ODC) activity and hepatic heme oxygenase (HO) activity, but did not cause any DNA damage in adult female rat liver or lung, suggesting that arsenite may be a promoter of carcinogenesis. sodium arsenite 35-50 ornithine decarboxylase 1 Rattus norvegicus 94-97 8969269-6 1996 Exposure of SPAEC to either heat (43 degrees C, 90 min) or sodium arsenite (100 microM, 90 min) induced expression of heat-shock protein-70 (HSP-70). sodium arsenite 59-74 heat shock 70 kDa protein 1A/1B Ovis aries 118-139 8969269-6 1996 Exposure of SPAEC to either heat (43 degrees C, 90 min) or sodium arsenite (100 microM, 90 min) induced expression of heat-shock protein-70 (HSP-70). sodium arsenite 59-74 heat shock 70 kDa protein 1A/1B Ovis aries 141-147 8970379-4 1996 In contrast, rats exposed to heat stress or to sodium arsenite 18 h prior to LPS had significantly lower levels of plasma TNF-alpha. sodium arsenite 47-62 tumor necrosis factor Rattus norvegicus 122-131 8903404-6 1996 Sodium arsenite (Ars) or hyperthermia (43 degrees C) induced the synthesis of hsp72 messenger RNA (mRNA) and protein in hepatocytes, indicating activation of the HSR. sodium arsenite 0-15 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 78-83 8917704-3 1996 Treatment with sodium arsenite resulted in a significant increase in cell proliferation, as indicated by increases in cell numbers, c-myc gene expression, and incorporation of [3H]thymidine into cellular DNA. sodium arsenite 15-30 MYC proto-oncogene, bHLH transcription factor Homo sapiens 132-137 8917706-0 1996 Expression of the 25-kDa heat-shock protein (HSP27) correlates with resistance to the toxicity of cadmium chloride, mercuric chloride, cis-platinum(II)-diammine dichloride, or sodium arsenite in mouse embryonic stem cells transfected with sense or antisense HSP27 cDNA. sodium arsenite 176-191 heat shock protein 1 Mus musculus 45-50 8917706-3 1996 Compared to the parental ES cell lines or ES cells transfected with the vector lacking any HSP27 sequence, all ES cell lines overexpressing HSP27 were resistant to killing by cadmium chloride (CdCl2), mercuric chloride (HgCl2), cis-platinum(II)-diammine dichloride (cDDP), sodium arsenite (NaAsO2), and heat while ES cell lines expressing reduced HSP27 were more sensitive to metal toxicity and heat. sodium arsenite 273-288 heat shock protein 1 Mus musculus 140-145 8917706-3 1996 Compared to the parental ES cell lines or ES cells transfected with the vector lacking any HSP27 sequence, all ES cell lines overexpressing HSP27 were resistant to killing by cadmium chloride (CdCl2), mercuric chloride (HgCl2), cis-platinum(II)-diammine dichloride (cDDP), sodium arsenite (NaAsO2), and heat while ES cell lines expressing reduced HSP27 were more sensitive to metal toxicity and heat. sodium arsenite 273-288 heat shock protein 1 Mus musculus 140-145 8917706-3 1996 Compared to the parental ES cell lines or ES cells transfected with the vector lacking any HSP27 sequence, all ES cell lines overexpressing HSP27 were resistant to killing by cadmium chloride (CdCl2), mercuric chloride (HgCl2), cis-platinum(II)-diammine dichloride (cDDP), sodium arsenite (NaAsO2), and heat while ES cell lines expressing reduced HSP27 were more sensitive to metal toxicity and heat. sodium arsenite 290-296 heat shock protein 1 Mus musculus 140-145 8917706-3 1996 Compared to the parental ES cell lines or ES cells transfected with the vector lacking any HSP27 sequence, all ES cell lines overexpressing HSP27 were resistant to killing by cadmium chloride (CdCl2), mercuric chloride (HgCl2), cis-platinum(II)-diammine dichloride (cDDP), sodium arsenite (NaAsO2), and heat while ES cell lines expressing reduced HSP27 were more sensitive to metal toxicity and heat. sodium arsenite 290-296 heat shock protein 1 Mus musculus 140-145 8798781-7 1996 We now report that sodium arsenite, a prototype for stressors fostering cytoplasmic protein misfolding, also inhibits translational initiation through activation of PKR while subsequently inducing the heat shock protein (HSP) chaperones. sodium arsenite 19-34 eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens 165-168 8798781-7 1996 We now report that sodium arsenite, a prototype for stressors fostering cytoplasmic protein misfolding, also inhibits translational initiation through activation of PKR while subsequently inducing the heat shock protein (HSP) chaperones. sodium arsenite 19-34 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 201-219 8798781-7 1996 We now report that sodium arsenite, a prototype for stressors fostering cytoplasmic protein misfolding, also inhibits translational initiation through activation of PKR while subsequently inducing the heat shock protein (HSP) chaperones. sodium arsenite 19-34 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 221-224 8841493-1 1996 In this study, we have examined the mutagenicity of sodium arsenite at the xanthine-guanine phosphoribosyltransferase locus (ypt) in a pSV2 gpt-transformed CHO cell line, AS52. sodium arsenite 52-67 alanine aminotransferase 1 Cricetulus griseus 140-143 8816775-6 1996 The nuclear localization of PKN was also observed when the cells were exposed to other stresses such as sodium arsenite and serum starvation. sodium arsenite 104-119 protein kinase N1 Mus musculus 28-31 8875078-7 1996 Injection of sodium arsenite into mice resulted in increased endogenous alpha B-crystallin expression in the adrenal gland and possibly the liver. sodium arsenite 13-28 crystallin, alpha B Mus musculus 72-90 8751576-6 1996 RESULTS: Sodium arsenite or hyperthermia induced the synthesis of hsp70 protein in AKN-1 cells, indicating activation of the HSR. sodium arsenite 9-24 heat shock protein family A (Hsp70) member 4 Homo sapiens 66-71 8663271-3 1996 In this study, we report that the calcium ionophore A23187, a glucose-regulated protein (GRP) inducer, dramatically inhibits HSP70 synthesis and HSP70 mRNA transcription after induction by heat shock, sodium arsenite, or prostaglandin A1 treatment in human K562 cells. sodium arsenite 201-216 gastrin releasing peptide Homo sapiens 62-87 8663271-3 1996 In this study, we report that the calcium ionophore A23187, a glucose-regulated protein (GRP) inducer, dramatically inhibits HSP70 synthesis and HSP70 mRNA transcription after induction by heat shock, sodium arsenite, or prostaglandin A1 treatment in human K562 cells. sodium arsenite 201-216 gastrin releasing peptide Homo sapiens 89-92 8836877-1 1996 Exposure of osteoblast-like MC3T3-E1 cells to sodium arsenite (arsenite) increased the level of heat shock protein 27 (hsp27). sodium arsenite 46-61 heat shock protein 1 Mus musculus 96-117 8836877-1 1996 Exposure of osteoblast-like MC3T3-E1 cells to sodium arsenite (arsenite) increased the level of heat shock protein 27 (hsp27). sodium arsenite 46-61 heat shock protein 1 Mus musculus 119-124 8662954-4 1996 In this report we have demonstrated that treatment of rat pheochromocytoma PC12 cells with sodium arsenite leads to enhanced expression of C/EBP-beta and GADD153 (growth arrest and DNA damage inducible gene 153) but not other C/EBPs. sodium arsenite 91-106 CCAAT/enhancer binding protein beta Rattus norvegicus 139-149 8662954-4 1996 In this report we have demonstrated that treatment of rat pheochromocytoma PC12 cells with sodium arsenite leads to enhanced expression of C/EBP-beta and GADD153 (growth arrest and DNA damage inducible gene 153) but not other C/EBPs. sodium arsenite 91-106 DNA-damage inducible transcript 3 Rattus norvegicus 154-161 8662954-4 1996 In this report we have demonstrated that treatment of rat pheochromocytoma PC12 cells with sodium arsenite leads to enhanced expression of C/EBP-beta and GADD153 (growth arrest and DNA damage inducible gene 153) but not other C/EBPs. sodium arsenite 91-106 DNA-damage inducible transcript 3 Rattus norvegicus 163-210 8645700-8 1996 The induction of heme oxygenase-1 was assessed by measuring changes in mRNA levels or enzyme activities in response to several treatments, including heme, heavy metals, sodium arsenite, and heat shock, which have been shown to increase the expression of heme oxygenase. sodium arsenite 169-184 heme oxygenase 1 Gallus gallus 17-33 9222590-6 1996 While heat shock and sodium arsenite exposure resulted in the increased accumulation of hsp90 mRNA in A6 cells, treatment with cadmium chloride and zinc chloride did not. sodium arsenite 21-36 heat shock protein HSP 90-beta Xenopus laevis 88-93 9222590-7 1996 Also, exposure of A6 cells to concurrent heat shock and sodium arsenite produced a mild synergistic response with respect to hsp90 mRNA levels in contrast to hsp70 mRNA levels which displayed a strong synergistic effect. sodium arsenite 56-71 heat shock protein HSP 90-beta Xenopus laevis 125-130 8556709-4 1996 We observed that the activated Raf significantly potentiated the induction of MDRCAT activity in GHE-L cells by sodium arsenite or heat shock, which stimulates heat shock factor (HSF) binding to HSE. sodium arsenite 112-127 zinc fingers and homeoboxes 2 Homo sapiens 31-34 8556709-4 1996 We observed that the activated Raf significantly potentiated the induction of MDRCAT activity in GHE-L cells by sodium arsenite or heat shock, which stimulates heat shock factor (HSF) binding to HSE. sodium arsenite 112-127 interleukin 6 Homo sapiens 179-182 8556713-4 1996 Sodium arsenite increased rat hepatic ODC activity at 1.6 and 24.6 mg/kg and hepatic heme oxygenase activity at 8.2 and 24.6 mg/kg, but did not cause any DNA damage. sodium arsenite 0-15 ornithine decarboxylase 1 Rattus norvegicus 38-41 8874798-4 1996 Treatment of the transfected cells with transition metallic ions (cadmium, cobalt, and zinc) or sodium arsenite produced increases in activities of luciferase or chloramphenicol acetyl transferase, relative to beta-galactosidase, and this activity mapped to the first 122 base pairs of the promoter. sodium arsenite 96-111 galactosidase beta 1 Gallus gallus 210-228 8874798-7 1996 We conclude that the heme-dependent induction of the liver metallothionein gene depends upon DNA region(s) outside the regulatory region of the chick metallothionein gene studied here and that elements within the first 122 base pairs of the metallothionein promoter are sufficient to confer responsiveness to transition metals or sodium arsenite. sodium arsenite 330-345 metallothionein 4 Gallus gallus 59-74 8717371-3 1996 Recently we demonstrated [4] that stress, in the form of heat shock, ethanol and sodium arsenite treatment, transcriptionally activates the beta-APP gene. sodium arsenite 81-96 amyloid beta precursor protein Homo sapiens 140-148 8902523-3 1996 In the present study, we examined ERK, JNK/SAPK, and p38 activation in cells treated with the sulfhydryl-reactive agent sodium arsenite. sodium arsenite 120-135 Eph receptor B1 Rattus norvegicus 34-37 8902523-3 1996 In the present study, we examined ERK, JNK/SAPK, and p38 activation in cells treated with the sulfhydryl-reactive agent sodium arsenite. sodium arsenite 120-135 mitogen-activated protein kinase 8 Rattus norvegicus 39-47 8902523-3 1996 In the present study, we examined ERK, JNK/SAPK, and p38 activation in cells treated with the sulfhydryl-reactive agent sodium arsenite. sodium arsenite 120-135 mitogen activated protein kinase 14 Rattus norvegicus 53-56 8572246-3 1995 Exposure of RPASMC to sodium arsenite or heat led to expression of heat shock protein-70 (HSP-70) in a time- and concentration-dependent manner. sodium arsenite 22-37 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 67-88 8572246-3 1995 Exposure of RPASMC to sodium arsenite or heat led to expression of heat shock protein-70 (HSP-70) in a time- and concentration-dependent manner. sodium arsenite 22-37 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 90-96 7492272-9 1995 Expression of HSP-72 was detected after ECs were treated both with heat shock and sodium arsenite (40 to 320 mumol/L) for 6 hours. sodium arsenite 82-97 heat shock protein family A (Hsp70) member 1A Homo sapiens 14-20 8647995-3 1995 In the present study, we examined the effects of heat, chemicals (azetidine and sodium arsenite), ultraviolet (UV) light, and gamma-ray irradiation on the induction of HSP72 in cultured human skin melanoma cell lines (P-39 and G-361), a human skin squamous cell carcinoma cell line (HSC-1), and an SV40-transformed human lung fibroblast cell line (WI38VA13) as a control. sodium arsenite 80-95 heat shock protein family A (Hsp70) member 1A Homo sapiens 168-173 7729015-4 1995 Treatment of RASMCs with hemin and sodium arsenite, which are inducers of HO-1, stimulated RASMC cGMP without stimulating nitrite release or inducible NO synthase expression, and the induced elevations of cGMP were not inhibited by the NO synthase inhibitor NG-methyl-L-arginine. sodium arsenite 35-50 heme oxygenase 1 Rattus norvegicus 74-78 7729015-4 1995 Treatment of RASMCs with hemin and sodium arsenite, which are inducers of HO-1, stimulated RASMC cGMP without stimulating nitrite release or inducible NO synthase expression, and the induced elevations of cGMP were not inhibited by the NO synthase inhibitor NG-methyl-L-arginine. sodium arsenite 35-50 nitric oxide synthase 2 Rattus norvegicus 141-162 7899564-2 1995 Thermotolerance as determined by clonogenic survival was induced not only by prior heating at 44 degrees C for 30 min but also by prior treatment with 100 microM sodium arsenite for 1 h and 5 micrograms/ml prostaglandin J2 for 4 h. These treatments concomitantly induced both hsp-70 (p72, inducible form) and hsp-40. sodium arsenite 162-177 heat shock protein 1B Mus musculus 276-282 7899564-2 1995 Thermotolerance as determined by clonogenic survival was induced not only by prior heating at 44 degrees C for 30 min but also by prior treatment with 100 microM sodium arsenite for 1 h and 5 micrograms/ml prostaglandin J2 for 4 h. These treatments concomitantly induced both hsp-70 (p72, inducible form) and hsp-40. sodium arsenite 162-177 DEAD box helicase 17 Mus musculus 284-287 7899564-2 1995 Thermotolerance as determined by clonogenic survival was induced not only by prior heating at 44 degrees C for 30 min but also by prior treatment with 100 microM sodium arsenite for 1 h and 5 micrograms/ml prostaglandin J2 for 4 h. These treatments concomitantly induced both hsp-70 (p72, inducible form) and hsp-40. sodium arsenite 162-177 DnaJ heat shock protein family (Hsp40) member B1 Mus musculus 309-315 8526746-7 1995 Furthermore, sodium arsenite treatment did not apparently affect glucose-6-phosphate dehydrogenase activity, but resulted in significantly increased glutathione levels and superoxide dismutase activity, slightly decreased glutathione peroxidase activity, and significantly decreased catalase activity. sodium arsenite 13-28 catalase Homo sapiens 283-291 8526746-8 1995 Sodium arsenite toxicity was partly reduced by addition of catalase to the culture medium. sodium arsenite 0-15 catalase Homo sapiens 59-67 7600446-0 1995 Selective increase of rat lung cytochrome P450 1A1 dependent monooxygenase activity after acute sodium arsenite administration. sodium arsenite 96-111 cytochrome P450, family 1, subfamily a, polypeptide 1 Rattus norvegicus 31-50 7737136-5 1995 Sodium arsenite treatment also inhibited the activities of serine/threonine protein phosphatases and enhanced phosphorylation levels of a small heat shock protein (HSP27). sodium arsenite 0-15 heat shock protein family B (small) member 1 Homo sapiens 164-169 7955528-3 1994 In the FRTL5 rat cell line, which had been heated at 42.5 degrees C or treated with sodium arsenite, expression of hsp-72 was examined with immunoperoxidase staining and immunoprecipitation of the metabolically labelled protein using a specific MoAb. sodium arsenite 84-99 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 115-121 7933069-6 1994 The possibility that HSP70 could be a mediator of the antiviral effect is suggested by the fact that treatment with other classical inducers of HSP70, including sodium arsenite, cadmium, and heat shock at 42 degrees C for 5 h, also selectively prevented SV protein synthesis as long as heat shock protein synthesis occurred. sodium arsenite 161-176 heat shock protein 1B Mus musculus 21-26 7933069-6 1994 The possibility that HSP70 could be a mediator of the antiviral effect is suggested by the fact that treatment with other classical inducers of HSP70, including sodium arsenite, cadmium, and heat shock at 42 degrees C for 5 h, also selectively prevented SV protein synthesis as long as heat shock protein synthesis occurred. sodium arsenite 161-176 heat shock protein 1B Mus musculus 144-149 7858064-5 1994 Treatment of FS-4 cells with sodium arsenite led to a very strong increase in the phosphorylation of Hsp28 demonstrable after 5 min and persisting for at least 4 h. Tyrosine phosphorylation of pp42 and pp44 MAP kinases was increased by TNF treatment, whereas arsenite produced a modest increase in tyrosine phosphorylation of pp44 while decreasing that of pp42 MAP kinase. sodium arsenite 29-44 heat shock protein family B (small) member 1 Homo sapiens 101-106 7858064-5 1994 Treatment of FS-4 cells with sodium arsenite led to a very strong increase in the phosphorylation of Hsp28 demonstrable after 5 min and persisting for at least 4 h. Tyrosine phosphorylation of pp42 and pp44 MAP kinases was increased by TNF treatment, whereas arsenite produced a modest increase in tyrosine phosphorylation of pp44 while decreasing that of pp42 MAP kinase. sodium arsenite 29-44 tumor necrosis factor Homo sapiens 236-239 7858064-6 1994 The finding that sodium arsenite strongly increased Hsp28 phosphorylation, together with the resistance of TNF-induced phosphorylation to kinase inhibitors, supports the notion that increased serine phosphorylation of Hsp28 in this system involves inhibition of protein phosphatase activity. sodium arsenite 17-32 heat shock protein family B (small) member 1 Homo sapiens 52-57 7858064-6 1994 The finding that sodium arsenite strongly increased Hsp28 phosphorylation, together with the resistance of TNF-induced phosphorylation to kinase inhibitors, supports the notion that increased serine phosphorylation of Hsp28 in this system involves inhibition of protein phosphatase activity. sodium arsenite 17-32 heat shock protein family B (small) member 1 Homo sapiens 218-223 7983179-2 1994 Our data show that chemical treatments including sodium arsenite, cadmium chloride and sodium salicylate, induced significant synthesis of hsp70 and its mRNA. sodium arsenite 49-64 heat shock protein 1B Mus musculus 139-144 7735982-0 1994 Effect of ethanol and sodium arsenite on HSP-72 formation and on survival in a murine endotoxin model. sodium arsenite 22-37 heat shock protein 1A Mus musculus 41-47 7735982-3 1994 The purpose of this study was to determine if in vivo administration of sodium arsenite (NaAsO2) or ethanol, inducers of HSPs in isolated cells, induced HSP-72 production in lung, liver, kidney, and duodenum (organs known to induce HSP-72 by heat) and improved survival from endotoxin. sodium arsenite 72-87 heat shock protein 1A Mus musculus 153-159 7735982-3 1994 The purpose of this study was to determine if in vivo administration of sodium arsenite (NaAsO2) or ethanol, inducers of HSPs in isolated cells, induced HSP-72 production in lung, liver, kidney, and duodenum (organs known to induce HSP-72 by heat) and improved survival from endotoxin. sodium arsenite 72-87 heat shock protein 1A Mus musculus 232-238 7735982-3 1994 The purpose of this study was to determine if in vivo administration of sodium arsenite (NaAsO2) or ethanol, inducers of HSPs in isolated cells, induced HSP-72 production in lung, liver, kidney, and duodenum (organs known to induce HSP-72 by heat) and improved survival from endotoxin. sodium arsenite 89-95 heat shock protein 1A Mus musculus 153-159 7735982-3 1994 The purpose of this study was to determine if in vivo administration of sodium arsenite (NaAsO2) or ethanol, inducers of HSPs in isolated cells, induced HSP-72 production in lung, liver, kidney, and duodenum (organs known to induce HSP-72 by heat) and improved survival from endotoxin. sodium arsenite 89-95 heat shock protein 1A Mus musculus 232-238 7735982-7 1994 Ethanol induced HSP-72 in kidney, 50% that of the standard (i.e., pooled livers isolated from heat-treated mice); NaAsO2 induced HSP-72 in kidney (approximately 50% of standard) and liver (approximately 21% of standard). sodium arsenite 114-120 heat shock protein 1A Mus musculus 129-135 7794296-11 1994 CONCLUSIONS: We conclude that in vivo injection of sodium arsenite induces expression of HSP-72 in the lungs, and confers transient protection against experimental sepsis during the period that heat shock proteins are also expressed. sodium arsenite 51-66 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 89-95 8187816-5 1994 Both the mRNA levels and the secretion of osteonectin increased concurrently when Pam and HSC-1 cells cultured in low calcium medium were exposed to various stresses including heat shock and treatment with sodium arsenite or L-azetidine-2-carboxylic acid. sodium arsenite 206-221 secreted acidic cysteine rich glycoprotein Mus musculus 42-53 8187816-5 1994 Both the mRNA levels and the secretion of osteonectin increased concurrently when Pam and HSC-1 cells cultured in low calcium medium were exposed to various stresses including heat shock and treatment with sodium arsenite or L-azetidine-2-carboxylic acid. sodium arsenite 206-221 peptidylglycine alpha-amidating monooxygenase Homo sapiens 82-85 7930803-6 1994 Our studies show that HSF-1 is phosphorylated following heat shock (43 degrees C for 1 h), hypoxia (5 h exposure to 0.02% oxygen), 8% ethanol (1 h exposure at 37 degrees C), or 200 microM sodium arsenite (1 h exposure at 37 degrees C). sodium arsenite 188-203 heat shock transcription factor 1 Homo sapiens 22-27 8157658-3 1994 Exposure of cells to chemical stressors, namely, NaAsO2 and CdCl2, also enhanced the dissociation of L-hsp27. sodium arsenite 49-55 heat shock protein family B (small) member 1 Homo sapiens 103-108 8355691-5 1993 HSF activation in response to treatment with sodium arsenite or the proline analog azetidine was also depressed in hsp70-expressing cells relative to that in the nontransfected control cells. sodium arsenite 45-60 interleukin 6 Homo sapiens 0-3 8355691-5 1993 HSF activation in response to treatment with sodium arsenite or the proline analog azetidine was also depressed in hsp70-expressing cells relative to that in the nontransfected control cells. sodium arsenite 45-60 heat shock protein family A (Hsp70) member 4 Homo sapiens 115-120 8464927-2 1993 Our studies on the response of rodent cells to heat shock or sodium arsenite indicate that a high level of HSF-DNA-binding activity, by itself, is not sufficient for the induction of hsp70 mRNA synthesis; furthermore, a high level of HSF binding is also not necessary for this induction. sodium arsenite 61-76 interleukin 6 Homo sapiens 107-110 8431965-1 1993 Tissue specific changes in the cytochrome P-450 (P-450) monooxygenase system were observed following a single subcutaneous dose of sodium arsenite (75 mumol/kg), a known inducer of stress proteins. sodium arsenite 131-146 cytochrome P450 3A14 Cavia porcellus 31-47 8433029-1 1993 HSP72 levels in the cellular and the nuclear (TX-insoluble) fraction before and after heating of heat- and sodium arsenite-induced thermotolerant and non-tolerant HeLa S3 cells have been investigated by 1D- and 2D-electrophoresis, followed by Western blotting and immunostaining, using a newly developed monoclonal antibody that specifically detects HSP72 (Heine et al. sodium arsenite 107-122 heat shock protein family A (Hsp70) member 1A Homo sapiens 0-5 1417842-0 1992 The adenovirus E3 region 14.7 kDa protein, heat and sodium arsenite inhibit the TNF-induced release of arachidonic acid. sodium arsenite 52-67 tumor necrosis factor Homo sapiens 80-83 1417842-1 1992 In this report we show that the adenovirus E3 region 14.7 kDa protein, heat and sodium arsenite, which have been defined previously as inhibitors of cytolysis, inhibit the tumor necrosis factor-alpha (TNF)-induced release of 3H-arachidonic acid from cycloheximide-sensitized C3HA fibroblasts. sodium arsenite 80-95 tumor necrosis factor Homo sapiens 172-199 1417842-1 1992 In this report we show that the adenovirus E3 region 14.7 kDa protein, heat and sodium arsenite, which have been defined previously as inhibitors of cytolysis, inhibit the tumor necrosis factor-alpha (TNF)-induced release of 3H-arachidonic acid from cycloheximide-sensitized C3HA fibroblasts. sodium arsenite 80-95 tumor necrosis factor Homo sapiens 201-204 1523582-3 1992 At embryotoxic exposures, sodium arsenite also induced the synthesis of three heat shock proteins (hsps), one of which is recognized by a monoclonal antibody specific for the heat-inducible hsp 72. sodium arsenite 26-41 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 190-196 1523582-4 1992 In addition, sodium arsenite induced the accumulation of heat-inducible hsp 70 mRNA. sodium arsenite 13-28 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 72-78 1597467-1 1992 The involvement of a vicinally spaced dithiol group in steroid binding to the glucocorticoid receptor has been deduced from experiments with the thiol-specific reagent methyl methanethiolsulfonate and the vicinal dithiol-specific reagent sodium arsenite. sodium arsenite 238-253 nuclear receptor subfamily 3, group C, member 1 Rattus norvegicus 78-101 1607378-7 1992 In cells exposed to either an amino acid analog or sodium arsenite, two potent inducers of the stress response, newly synthesized proteins bind to but are not released from hsp 70. sodium arsenite 51-66 heat shock protein family A (Hsp70) member 4 Homo sapiens 173-179 1581359-2 1992 When the cells were treated with sodium arsenite or ethanol for 1 h at 37 degrees C, the activity of SAT increased time- and dose-dependently. sodium arsenite 33-48 spermidine/spermine N1-acetyl transferase 1 Mus musculus 101-104 1607738-2 1992 In NRK cells, hsp70 was clearly induced by conditioning treatments (42 degrees C for 2 h, 45 degrees C for 15 min or 100 microM sodium arsenite for 1 h). sodium arsenite 128-143 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 14-19 1569328-2 1992 The present study provided new evidence that HSP 72 was induced not only by heat and chemical agents, such as L-azetidine 2-carboxylic acid, and sodium arsenite, but also by ultraviolet (UV B and C). sodium arsenite 145-160 heat shock protein family A (Hsp70) member 1A Homo sapiens 45-51 1360409-2 1992 We investigated MDR1 gene expression in the well-differentiated hepatoma cell line HepG2 after exposure to several stresses and found that sodium arsenite treatment increased MDR1 gene expression 2.6-fold. sodium arsenite 139-154 ATP binding cassette subfamily B member 1 Homo sapiens 16-20 1360409-2 1992 We investigated MDR1 gene expression in the well-differentiated hepatoma cell line HepG2 after exposure to several stresses and found that sodium arsenite treatment increased MDR1 gene expression 2.6-fold. sodium arsenite 139-154 ATP binding cassette subfamily B member 1 Homo sapiens 175-179 1312348-12 1992 Interestingly, sodium arsenite produced both a greater induction of hsp 90 and hsp 70 synthesis and a greater fold enhancement of PR-mediated gene transcription than did heat shock. sodium arsenite 15-30 heat shock protein 90 alpha family class A member 1 Homo sapiens 68-74 1312348-12 1992 Interestingly, sodium arsenite produced both a greater induction of hsp 90 and hsp 70 synthesis and a greater fold enhancement of PR-mediated gene transcription than did heat shock. sodium arsenite 15-30 heat shock protein family A (Hsp70) member 4 Homo sapiens 79-85 1730584-6 1992 A similar shift to nuclear localization for unliganded glucocorticoid receptor is noted in L929 and WCL2 cells subjected to chemical shock (sodium arsenite). sodium arsenite 140-155 nuclear receptor subfamily 3, group C, member 1 Mus musculus 55-78 1396606-2 1992 However, posttreatment of ultraviolet light (UV) irradiated cells with sodium arsenite synergistically enhances the mutation frequency on the hypoxanthine (guanine) phosphoribosyltransferase locus. sodium arsenite 71-86 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 142-190 1396606-3 1992 To investigate the molecular mechanism of the comutagenic effects of sodium arsenite, we characterized the alterations of nucleotide sequences in 30 UV-induced and 39 sodium arsenite enhanced hprt mutants from Chinese hamster ovary K1 cells by direct sequencing of mRNA-PCR amplified cDNA. sodium arsenite 69-84 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 192-196 1396606-3 1992 To investigate the molecular mechanism of the comutagenic effects of sodium arsenite, we characterized the alterations of nucleotide sequences in 30 UV-induced and 39 sodium arsenite enhanced hprt mutants from Chinese hamster ovary K1 cells by direct sequencing of mRNA-PCR amplified cDNA. sodium arsenite 167-182 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 192-196 2023914-2 1991 Indeed, accumulation of alpha B-crystallin was detected immunologically in NIH 3T3 cells after incubation at elevated temperatures and after addition of Cd2+ or sodium arsenite to these cells. sodium arsenite 161-176 crystallin, alpha B Mus musculus 24-42 2032293-0 1991 Sodium arsenite induces ATP depletion and mitochondrial damage in HeLa cells. sodium arsenite 0-15 ATPase phospholipid transporting 8A2 Homo sapiens 24-27 2032293-1 1991 Our present results show that treatment with sodium arsenite apparently decreases cellular ATP levels in a dose- and time-dependent manner in HeLa S-3 cells. sodium arsenite 45-60 ATPase phospholipid transporting 8A2 Homo sapiens 91-94 2032293-2 1991 The reduction in ATP induced by sodium arsenite was possibly through mitochondrial damage, since treatment with sodium arsenite resulted in reduction of rhodamine 123 accumulation and disruption of the structure of the cristae in mitochondria. sodium arsenite 32-47 ATPase phospholipid transporting 8A2 Homo sapiens 17-20 2032293-2 1991 The reduction in ATP induced by sodium arsenite was possibly through mitochondrial damage, since treatment with sodium arsenite resulted in reduction of rhodamine 123 accumulation and disruption of the structure of the cristae in mitochondria. sodium arsenite 112-127 ATPase phospholipid transporting 8A2 Homo sapiens 17-20 2032293-4 1991 The levels of ATP depletion were correlated with the killing effects of sodium arsenite in HeLa S-3 cells. sodium arsenite 72-87 ATPase phospholipid transporting 8A2 Homo sapiens 14-17 2005667-2 1991 Female balb/c mice injected with arsanilic acid conjugated to a carrier protein (ovalbumin) were shown to produce antibodies (arsenic reactive serum, ARS) reactive with arsanilic acid and sodium arsenite. sodium arsenite 188-203 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 81-90 2005667-5 1991 Following multiple injections of 100 micrograms of arsanilic acid--ovalbumin compound, mortality on injection with sodium arsenite 0.87 mg/kg i.p. sodium arsenite 115-130 serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene Mus musculus 67-76 1687901-1 1991 In human chorionic villus tissue at the 10-17th week of a normal pregnancy, heat shock proteins (hsp70, hsp73, hsp85, and hsp105) were induced in vitro by a heat shock or by exposure to sodium arsenite or cadmium chloride. sodium arsenite 186-201 heat shock protein family A (Hsp70) member 4 Homo sapiens 97-102 1687901-1 1991 In human chorionic villus tissue at the 10-17th week of a normal pregnancy, heat shock proteins (hsp70, hsp73, hsp85, and hsp105) were induced in vitro by a heat shock or by exposure to sodium arsenite or cadmium chloride. sodium arsenite 186-201 heat shock protein family A (Hsp70) member 8 Homo sapiens 104-109 1687901-1 1991 In human chorionic villus tissue at the 10-17th week of a normal pregnancy, heat shock proteins (hsp70, hsp73, hsp85, and hsp105) were induced in vitro by a heat shock or by exposure to sodium arsenite or cadmium chloride. sodium arsenite 186-201 heat shock protein family H (Hsp110) member 1 Homo sapiens 122-128 1687901-2 1991 In dispersed cells of the whole mouse embryo on the 11th day of development, heat shock proteins (hsp73 and hsp105) were induced by a heat shock or by exposure to sodium arsenite, but not by exposure to cadmium chloride. sodium arsenite 163-178 heat shock protein 8 Mus musculus 98-103 1687901-2 1991 In dispersed cells of the whole mouse embryo on the 11th day of development, heat shock proteins (hsp73 and hsp105) were induced by a heat shock or by exposure to sodium arsenite, but not by exposure to cadmium chloride. sodium arsenite 163-178 heat shock 105kDa/110kDa protein 1 Mus musculus 108-114 2266108-13 1990 Induction of p56 also occurs in IM-9 cells subjected to chemical stress (sodium arsenite). sodium arsenite 73-88 interferon induced protein with tetratricopeptide repeats 1 Homo sapiens 13-16 2111988-3 1990 Sodium arsenite induced both hsp 70 and c-fos transcripts. sodium arsenite 0-15 heat shock protein 1B Mus musculus 29-35 2111988-3 1990 Sodium arsenite induced both hsp 70 and c-fos transcripts. sodium arsenite 0-15 FBJ osteosarcoma oncogene Mus musculus 40-45 2340977-7 1990 Sodium arsenite induced the highest levels of synthesis of these two proteins, approximately 10-fold and 3-fold increases in hsp-70 and hsp-90, respectively. sodium arsenite 0-15 heat shock protein family A (Hsp70) member 4 Homo sapiens 125-131 2340977-7 1990 Sodium arsenite induced the highest levels of synthesis of these two proteins, approximately 10-fold and 3-fold increases in hsp-70 and hsp-90, respectively. sodium arsenite 0-15 heat shock protein 90 alpha family class A member 1 Homo sapiens 136-142 1967174-6 1990 Exposure of HTB-46 cells to heat shock, sodium arsenite, or cadmium chloride led to a 7- to 8-fold increase in MDR1 mRNA levels. sodium arsenite 40-55 ATP binding cassette subfamily B member 1 Homo sapiens 111-115 1967174-8 1990 The levels of the multidrug transporter, P-glycoprotein, as measured by immunoprecipitation, were also increased after heat shock and sodium arsenite treatment. sodium arsenite 134-149 ATP binding cassette subfamily B member 1 Homo sapiens 41-55 2256819-6 1990 These studies showed that (a) sodium arsenite and AZC enhanced the cellular levels of hsp47 in both types of fibroblast, (b) the colligin/hsp47 levels expressed were associated with elevated levels of protein and collagen production and (c) the presence of colligin/hsp47 was decreased under conditions of serum deprivation. sodium arsenite 30-45 serpin family H member 1 Homo sapiens 86-91 2256819-6 1990 These studies showed that (a) sodium arsenite and AZC enhanced the cellular levels of hsp47 in both types of fibroblast, (b) the colligin/hsp47 levels expressed were associated with elevated levels of protein and collagen production and (c) the presence of colligin/hsp47 was decreased under conditions of serum deprivation. sodium arsenite 30-45 serpin family H member 1 Homo sapiens 138-143 2256819-6 1990 These studies showed that (a) sodium arsenite and AZC enhanced the cellular levels of hsp47 in both types of fibroblast, (b) the colligin/hsp47 levels expressed were associated with elevated levels of protein and collagen production and (c) the presence of colligin/hsp47 was decreased under conditions of serum deprivation. sodium arsenite 30-45 serpin family H member 1 Homo sapiens 138-143 33774797-12 2021 CS-EA fractioned treated group overturned the sodium arsenite driven higher expression of pro-inflammatory cytokines and proapoptotic markers along with a low level of anti apoptotic Bcl-2 expression and comparatively lower NF-kappaB signalling in the uterus via regulating IKK beta kinase mostly by EGCG of CS-EA fraction. sodium arsenite 46-61 component of inhibitor of nuclear factor kappa B kinase complex Rattus norvegicus 274-282 25199681-0 2015 Increased susceptibility of H-Ras(G12V)-transformed human urothelial cells to the genotoxic effects of sodium arsenite. sodium arsenite 103-118 HRas proto-oncogene, GTPase Homo sapiens 28-33 34920032-4 2022 Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2. sodium arsenite 23-38 NLR family, pyrin domain containing 3 Rattus norvegicus 58-102 34920032-4 2022 Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2. sodium arsenite 23-38 NLR family, pyrin domain containing 3 Rattus norvegicus 104-109 34920032-4 2022 Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2. sodium arsenite 23-38 gasdermin D Rattus norvegicus 135-140 34920032-4 2022 Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2. sodium arsenite 40-46 NLR family, pyrin domain containing 3 Rattus norvegicus 58-102 34920032-4 2022 Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2. sodium arsenite 40-46 NLR family, pyrin domain containing 3 Rattus norvegicus 104-109 34920032-4 2022 Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2. sodium arsenite 40-46 gasdermin D Rattus norvegicus 135-140 34920032-4 2022 Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2. sodium arsenite 40-46 gasdermin D Rattus norvegicus 194-199 34920032-4 2022 Here, we observed that sodium arsenite (NaAsO2) activated NOD-like receptors containing pyrin domain 3 (NLRP3) inflammasomes, promoted GSDMD activation, induced pyroptosis and hepatic IR, while GSDMD knockdown attenuated pyroptosis and hepatic IR caused by NaAsO2. sodium arsenite 257-263 gasdermin D Rattus norvegicus 194-199 34920032-7 2022 We observed that NaAsO2 reduced the K48- and K63-linked ubiquitination of GSDMD, thereby inhibiting its degradation through the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway (ALP), causing GSDMD to accumulate and lyse into GSDMD-N, which promoted pyroptosis. sodium arsenite 17-23 gasdermin D Rattus norvegicus 74-79 34920032-7 2022 We observed that NaAsO2 reduced the K48- and K63-linked ubiquitination of GSDMD, thereby inhibiting its degradation through the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway (ALP), causing GSDMD to accumulate and lyse into GSDMD-N, which promoted pyroptosis. sodium arsenite 17-23 gasdermin D Rattus norvegicus 212-217 34920032-7 2022 We observed that NaAsO2 reduced the K48- and K63-linked ubiquitination of GSDMD, thereby inhibiting its degradation through the ubiquitin-proteasome system (UPS) and the autophagy-lysosome pathway (ALP), causing GSDMD to accumulate and lyse into GSDMD-N, which promoted pyroptosis. sodium arsenite 17-23 gasdermin D Rattus norvegicus 246-251 34920032-9 2022 Moreover, NaAsO2 reduced GSDMD ubiquitination and decreased its intracellular degradation, aggravating pyroptosis and hepatic IR. sodium arsenite 10-16 gasdermin D Rattus norvegicus 25-30 34798143-3 2022 The purpose of this work was to determine whether inorganic arsenic (NaAsO2) and its metabolites influenced the expression of PUMA in vivo and vitro, followed by investigating the mechanisms. sodium arsenite 69-75 BCL2 binding component 3 Homo sapiens 126-130 34798143-7 2022 According to the results of qRT-PCR and western blotting, NaAsO2 caused the overexpression of PUMA, not its metabolites. sodium arsenite 58-64 BCL2 binding component 3 Homo sapiens 94-98 34798143-8 2022 Furthermore, NaAsO2 induced phosphorylation of p53 at Ser315, 376, 392, and Thr55, and acetylation of p53 at K370, 382 with a dose-response relationship, suggesting the contribution of PUMA up-regulation to p53 phosphorylation and acetylation. sodium arsenite 13-19 tumor protein p53 Homo sapiens 47-50 34798143-8 2022 Furthermore, NaAsO2 induced phosphorylation of p53 at Ser315, 376, 392, and Thr55, and acetylation of p53 at K370, 382 with a dose-response relationship, suggesting the contribution of PUMA up-regulation to p53 phosphorylation and acetylation. sodium arsenite 13-19 tumor protein p53 Homo sapiens 102-105 34798143-8 2022 Furthermore, NaAsO2 induced phosphorylation of p53 at Ser315, 376, 392, and Thr55, and acetylation of p53 at K370, 382 with a dose-response relationship, suggesting the contribution of PUMA up-regulation to p53 phosphorylation and acetylation. sodium arsenite 13-19 BCL2 binding component 3 Homo sapiens 185-189 34798143-8 2022 Furthermore, NaAsO2 induced phosphorylation of p53 at Ser315, 376, 392, and Thr55, and acetylation of p53 at K370, 382 with a dose-response relationship, suggesting the contribution of PUMA up-regulation to p53 phosphorylation and acetylation. sodium arsenite 13-19 tumor protein p53 Homo sapiens 207-210 34798143-10 2022 The co-immunoprecipitation assay showed that the interaction between PUMA and Bcl-X enhanced in intensity responding to NaAsO2 exposure, disrupting the complexes of Bcl-X with other pro-survival Bcl-2-related proteins. sodium arsenite 120-126 BCL2 binding component 3 Homo sapiens 69-73 34798143-10 2022 The co-immunoprecipitation assay showed that the interaction between PUMA and Bcl-X enhanced in intensity responding to NaAsO2 exposure, disrupting the complexes of Bcl-X with other pro-survival Bcl-2-related proteins. sodium arsenite 120-126 BCL2 like 1 Homo sapiens 78-83 34798143-10 2022 The co-immunoprecipitation assay showed that the interaction between PUMA and Bcl-X enhanced in intensity responding to NaAsO2 exposure, disrupting the complexes of Bcl-X with other pro-survival Bcl-2-related proteins. sodium arsenite 120-126 BCL2 like 1 Homo sapiens 165-170 34798143-11 2022 To our knowledge, we first reported that NaAsO2 activated phosphorylation of p53 at Ser315, 376, and Thr55, as well as acetylation of p53 at K370. sodium arsenite 41-47 tumor protein p53 Homo sapiens 77-80 34798143-11 2022 To our knowledge, we first reported that NaAsO2 activated phosphorylation of p53 at Ser315, 376, and Thr55, as well as acetylation of p53 at K370. sodium arsenite 41-47 tumor protein p53 Homo sapiens 134-137 34943121-5 2021 Our work indicates that the depletion of CERKL increases the vulnerability of RPE mitochondria, which show a shorter size and altered shape, particularly upon sodium arsenite treatment. sodium arsenite 159-174 ceramide kinase like Homo sapiens 41-46 34897760-3 2022 Results revealed protective effect of both intermittent and continuous kisspeptin doses on reproductive organs against sodium arsenite-induced toxicity. sodium arsenite 119-134 KiSS-1 metastasis-suppressor Mus musculus 71-81 34217924-4 2021 One strain encoded as PMS5 with the highest resistance to 140-mM sodium arsenite and 600-mM sodium arsenate in tryptic soy broth was selected for further investigations. sodium arsenite 65-80 PMS1 homolog 2, mismatch repair system component pseudogene 3 Homo sapiens 22-26 34429248-4 2021 TDP-43 transgenic human iPS cells were constructed, differentiated into motor neurons, and then treated with MG-132 and sodium arsenite (stressors) to induce nuclear to cytoplasmic localization of TDP-43. sodium arsenite 120-135 TAR DNA binding protein Homo sapiens 0-6 34429248-4 2021 TDP-43 transgenic human iPS cells were constructed, differentiated into motor neurons, and then treated with MG-132 and sodium arsenite (stressors) to induce nuclear to cytoplasmic localization of TDP-43. sodium arsenite 120-135 TAR DNA binding protein Homo sapiens 197-203 34774526-6 2021 We further show that nsp1 interacts with Ras-GTPase-activating protein SH3-domain-binding protein 1 (G3BP1) and colocalizes with G3BP1 in SGs under sodium arsenite-induced stress. sodium arsenite 148-163 SH2 domain containing 3A Homo sapiens 21-25 34926170-0 2021 Co-exposure of sodium arsenite and uranyl acetate differentially alters gene expression in CD3/CD28 activated CD4+ T-cells. sodium arsenite 15-30 CD28 molecule Homo sapiens 95-99 34926170-0 2021 Co-exposure of sodium arsenite and uranyl acetate differentially alters gene expression in CD3/CD28 activated CD4+ T-cells. sodium arsenite 15-30 CD4 molecule Homo sapiens 110-113 34899304-2 2021 The results revealed that DIP pretreatment inhibited NaAsO2 induced L-02 cells apoptosis by increasing anti-apoptotic Bcl-2 expression and decreasing pro-apoptotic Bax expression. sodium arsenite 53-59 BCL2 apoptosis regulator Homo sapiens 118-123 34899304-2 2021 The results revealed that DIP pretreatment inhibited NaAsO2 induced L-02 cells apoptosis by increasing anti-apoptotic Bcl-2 expression and decreasing pro-apoptotic Bax expression. sodium arsenite 53-59 BCL2 associated X, apoptosis regulator Homo sapiens 164-167 34771016-8 2021 NaAsO2 increased the levels of TNF-alpha, 8-hydroxy-2-deoxy guanosine (8OHdG), malondialdehyde (MDA), reactive oxygen species (ROS), and high mobility group box 1 (HMGB1), increased the expression of TNF receptor type 1-associated death domain (TRADD) mRNA and telomerase reverse transcriptase, and decreased the expression of Klotho (KL) mRNA in both plasma and tissues. sodium arsenite 0-6 tumor necrosis factor Rattus norvegicus 31-40 34771016-8 2021 NaAsO2 increased the levels of TNF-alpha, 8-hydroxy-2-deoxy guanosine (8OHdG), malondialdehyde (MDA), reactive oxygen species (ROS), and high mobility group box 1 (HMGB1), increased the expression of TNF receptor type 1-associated death domain (TRADD) mRNA and telomerase reverse transcriptase, and decreased the expression of Klotho (KL) mRNA in both plasma and tissues. sodium arsenite 0-6 high mobility group box 1 Rattus norvegicus 137-162 34771016-8 2021 NaAsO2 increased the levels of TNF-alpha, 8-hydroxy-2-deoxy guanosine (8OHdG), malondialdehyde (MDA), reactive oxygen species (ROS), and high mobility group box 1 (HMGB1), increased the expression of TNF receptor type 1-associated death domain (TRADD) mRNA and telomerase reverse transcriptase, and decreased the expression of Klotho (KL) mRNA in both plasma and tissues. sodium arsenite 0-6 high mobility group box 1 Rattus norvegicus 164-169 34771016-8 2021 NaAsO2 increased the levels of TNF-alpha, 8-hydroxy-2-deoxy guanosine (8OHdG), malondialdehyde (MDA), reactive oxygen species (ROS), and high mobility group box 1 (HMGB1), increased the expression of TNF receptor type 1-associated death domain (TRADD) mRNA and telomerase reverse transcriptase, and decreased the expression of Klotho (KL) mRNA in both plasma and tissues. sodium arsenite 0-6 Klotho Rattus norvegicus 327-333 34771016-8 2021 NaAsO2 increased the levels of TNF-alpha, 8-hydroxy-2-deoxy guanosine (8OHdG), malondialdehyde (MDA), reactive oxygen species (ROS), and high mobility group box 1 (HMGB1), increased the expression of TNF receptor type 1-associated death domain (TRADD) mRNA and telomerase reverse transcriptase, and decreased the expression of Klotho (KL) mRNA in both plasma and tissues. sodium arsenite 0-6 Klotho Rattus norvegicus 335-337 34364127-4 2021 We found that NaAsO2 caused hepatic IR, activated NLRP3 inflammasome, and inhibited glycolysis pathway in vivo. sodium arsenite 14-20 NLR family pyrin domain containing 3 Homo sapiens 50-55 34364127-10 2021 In summary, after treatment with NaAsO2, NLRP3 inflammasome blocked the glycolytic pathway via binding to PKLR, which in turn caused hepatic IR. sodium arsenite 33-39 NLR family pyrin domain containing 3 Homo sapiens 41-46 34364127-10 2021 In summary, after treatment with NaAsO2, NLRP3 inflammasome blocked the glycolytic pathway via binding to PKLR, which in turn caused hepatic IR. sodium arsenite 33-39 pyruvate kinase L/R Homo sapiens 106-110 34303791-0 2021 Human prostate epithelial cells and prostate-derived stem cells malignantly transformed in vitro with sodium arsenite show impaired Toll like receptor -3 (TLR3)-associated anti-tumor pathway. sodium arsenite 102-117 toll like receptor 3 Homo sapiens 155-159 34616479-6 2021 Quantification of sodium arsenite-induced reactive oxygen species (ROS) was measured in TDP-43 stress granular cells using 2,7-diacetyl dichlorofluorescein diacetate. sodium arsenite 18-33 TAR DNA binding protein Homo sapiens 88-94 34348425-7 2021 In addition, SA inhibited catalase and glutathione-S-transferase (GST) activities, and depleted total thiol and glutathione (GSH) contents. sodium arsenite 13-15 Glutathione S transferase S1 Drosophila melanogaster 39-64 34348425-7 2021 In addition, SA inhibited catalase and glutathione-S-transferase (GST) activities, and depleted total thiol and glutathione (GSH) contents. sodium arsenite 13-15 Glutathione S transferase S1 Drosophila melanogaster 66-69 34348425-8 2021 Moreover, acetylcholinesterase activity significantly increased in flies treated with SA when compared with control. sodium arsenite 86-88 Acetylcholine esterase Drosophila melanogaster 10-30 34221922-6 2021 The effects of NaAsO2 on the methylation of H3 in the promoter regions of 78 kDa glucose-regulated protein, activating transcription factor 4 and C/EBP-homologous protein were evaluated by chromatin immunoprecipitation assay. sodium arsenite 15-21 heat shock protein family A (Hsp70) member 5 Homo sapiens 74-106 34221922-6 2021 The effects of NaAsO2 on the methylation of H3 in the promoter regions of 78 kDa glucose-regulated protein, activating transcription factor 4 and C/EBP-homologous protein were evaluated by chromatin immunoprecipitation assay. sodium arsenite 15-21 activating transcription factor 4 Homo sapiens 108-141 34221922-10 2021 NaAsO2 induces apoptosis in LO2 cells by activating the ERS-mediated apoptotic signaling pathway, at least partially by enhancing the methylation of H3 on the promoter regions of ERS-associated genes, including GRP78 and CHOP. sodium arsenite 0-6 heat shock protein family A (Hsp70) member 5 Homo sapiens 211-216 34221922-10 2021 NaAsO2 induces apoptosis in LO2 cells by activating the ERS-mediated apoptotic signaling pathway, at least partially by enhancing the methylation of H3 on the promoter regions of ERS-associated genes, including GRP78 and CHOP. sodium arsenite 0-6 DNA damage inducible transcript 3 Homo sapiens 221-225 35381244-5 2022 The results showed that low dose of NaAsO2 exacerbated DON-induced intestinal impairment by increasing intestinal permeability and decreasing the abundance of tight junction proteins (ZO-1, Occludin, Claudin-1). sodium arsenite 36-42 zonula occludens 1 Sus scrofa 184-188 35381244-5 2022 The results showed that low dose of NaAsO2 exacerbated DON-induced intestinal impairment by increasing intestinal permeability and decreasing the abundance of tight junction proteins (ZO-1, Occludin, Claudin-1). sodium arsenite 36-42 occludin Sus scrofa 190-198 35381244-5 2022 The results showed that low dose of NaAsO2 exacerbated DON-induced intestinal impairment by increasing intestinal permeability and decreasing the abundance of tight junction proteins (ZO-1, Occludin, Claudin-1). sodium arsenite 36-42 claudin 1 Sus scrofa 200-209 35381244-6 2022 Further, low dose of NaAsO2 enhanced the AhR signaling pathway and autophagy-related mRNA/protein expressions induced by DON. sodium arsenite 21-27 aryl hydrocarbon receptor Sus scrofa 41-44 35381244-7 2022 Interestingly, FICZ, an AhR activator, instead of CH223191, an AhR inhibitor, could alleviate toxicity of the low dose of NaAsO2 in the mice and IPEC-J2 cells. sodium arsenite 122-128 aryl-hydrocarbon receptor Mus musculus 24-27 35381244-7 2022 Interestingly, FICZ, an AhR activator, instead of CH223191, an AhR inhibitor, could alleviate toxicity of the low dose of NaAsO2 in the mice and IPEC-J2 cells. sodium arsenite 122-128 aryl-hydrocarbon receptor Mus musculus 63-66 35381244-11 2022 Hence, AhR and autophagy might be novel therapeutic targets to prevent or alleviate NaAsO2 combined with DON-induced intestinal barrier impairment. sodium arsenite 84-90 aryl hydrocarbon receptor Sus scrofa 7-10 35441311-6 2022 Using RNAi and RT-PCR, it has been further confirmed that OV modulates transcription factor SKN-1, the nuclear factor erythroid 2-related factor 2 (Nrf2) homologous, in C. elegans, enhancing the resistance of C. elegans against sodium arsenite stress. sodium arsenite 228-243 BZIP domain-containing protein;Protein skinhead-1 Caenorhabditis elegans 92-97 35624898-5 2022 This review focuses on the mechanisms regulating the mitochondrial formation of ROS after exposure to low concentrations of a specific arsenic compound, NaAsO2, and their crosstalk with the nuclear factor (erythroid-2 related) factor 2 antioxidant signaling and the endoplasmic reticulum stress response. sodium arsenite 153-159 NFE2 like bZIP transcription factor 2 Homo sapiens 190-235 35563241-11 2022 The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2). sodium arsenite 102-117 junctional adhesion molecule 2 Homo sapiens 260-264 35563241-11 2022 The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2). sodium arsenite 102-117 integrin subunit beta 3 Homo sapiens 266-271 35563241-11 2022 The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2). sodium arsenite 102-117 notch receptor 4 Homo sapiens 276-282 35563241-11 2022 The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2). sodium arsenite 102-117 claudin 2 Homo sapiens 311-316 35563241-11 2022 The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2). sodium arsenite 102-117 claudin 3 Homo sapiens 318-323 35563241-11 2022 The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2). sodium arsenite 102-117 gap junction protein beta 1 Homo sapiens 325-329 35563241-11 2022 The mRNA expression of genes related to cell junctions in T-84 cells was analyzed after exposure with sodium arsenite for 72 h. Changes in TEER correlated with mRNA expression of focal-adhesion-, tight-junction- and gap-junction-related genes (upregulation of Jam2, Itgb3 and Notch4 genes and downregulation of Cldn2, Cldn3, Gjb1, and Gjb2). sodium arsenite 102-117 gap junction protein beta 2 Homo sapiens 335-339 35259467-0 2022 Sodium arsenite accelerates D-galactose-induced aging in the testis of the rat: Evidence for mitochondrial oxidative damage, NF-kB, JNK, and apoptosis pathways. sodium arsenite 0-15 RELA proto-oncogene, NF-kB subunit Rattus norvegicus 125-130 35259467-0 2022 Sodium arsenite accelerates D-galactose-induced aging in the testis of the rat: Evidence for mitochondrial oxidative damage, NF-kB, JNK, and apoptosis pathways. sodium arsenite 0-15 mitogen-activated protein kinase 8 Rattus norvegicus 132-135 35351881-7 2022 Western blotting showed increased levels of cleaved PARP-1 and cleaved caspase-3 in SA-treated mice consistent with SA-induced apoptosis. sodium arsenite 84-86 poly (ADP-ribose) polymerase family, member 1 Mus musculus 52-58 35351881-7 2022 Western blotting showed increased levels of cleaved PARP-1 and cleaved caspase-3 in SA-treated mice consistent with SA-induced apoptosis. sodium arsenite 84-86 caspase 3 Mus musculus 71-80 35351881-7 2022 Western blotting showed increased levels of cleaved PARP-1 and cleaved caspase-3 in SA-treated mice consistent with SA-induced apoptosis. sodium arsenite 116-118 poly (ADP-ribose) polymerase family, member 1 Mus musculus 52-58 35351881-7 2022 Western blotting showed increased levels of cleaved PARP-1 and cleaved caspase-3 in SA-treated mice consistent with SA-induced apoptosis. sodium arsenite 116-118 caspase 3 Mus musculus 71-80 35313999-4 2022 RESULTS: SA treatment showed hepatic pathological injury and the elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) in serum, and induced the increases of malondialdehyde (MDA), Th17 cells, OX40 or IL-17A in liver tissues, which were consistently ameliorated by Lentinan intervention. sodium arsenite 9-11 glutamic pyruvic transaminase, soluble Mus musculus 79-103 35313999-4 2022 RESULTS: SA treatment showed hepatic pathological injury and the elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) in serum, and induced the increases of malondialdehyde (MDA), Th17 cells, OX40 or IL-17A in liver tissues, which were consistently ameliorated by Lentinan intervention. sodium arsenite 9-11 glutamic pyruvic transaminase, soluble Mus musculus 105-108 35313999-4 2022 RESULTS: SA treatment showed hepatic pathological injury and the elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) in serum, and induced the increases of malondialdehyde (MDA), Th17 cells, OX40 or IL-17A in liver tissues, which were consistently ameliorated by Lentinan intervention. sodium arsenite 9-11 tumor necrosis factor receptor superfamily, member 4 Mus musculus 220-224 35313999-4 2022 RESULTS: SA treatment showed hepatic pathological injury and the elevations of alanine aminotransferase (ALT) or aspartate aminotransferase (AST) in serum, and induced the increases of malondialdehyde (MDA), Th17 cells, OX40 or IL-17A in liver tissues, which were consistently ameliorated by Lentinan intervention. sodium arsenite 9-11 interleukin 17A Mus musculus 228-234 35313999-7 2022 CONCLUSION: Lentinan antagonizes SA-induced hepatotoxicity in mice, may be involved in the downregulations of pro-inflammatory OX40 or IL-17A and the activation of anti-oxidative Nrf2, NQO1 signals. sodium arsenite 33-35 tumor necrosis factor receptor superfamily, member 4 Mus musculus 127-131 35313999-7 2022 CONCLUSION: Lentinan antagonizes SA-induced hepatotoxicity in mice, may be involved in the downregulations of pro-inflammatory OX40 or IL-17A and the activation of anti-oxidative Nrf2, NQO1 signals. sodium arsenite 33-35 interleukin 17A Mus musculus 135-141 35298964-0 2022 NaAsO2 decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-kappaB/miR-21 signaling pathway. sodium arsenite 0-6 glutamate-cysteine ligase catalytic subunit Homo sapiens 45-49 35298964-0 2022 NaAsO2 decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-kappaB/miR-21 signaling pathway. sodium arsenite 0-6 nuclear factor kappa B subunit 1 Homo sapiens 144-153 35298964-0 2022 NaAsO2 decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-kappaB/miR-21 signaling pathway. sodium arsenite 0-6 microRNA 21 Homo sapiens 154-160 35298964-5 2022 However, the role of miR-21 in the mitochondrial pathway of cervical cancer cells induced by NaAsO2 through NF-kappaB/GCLC and GSH synthesis regulated oxidative stress is rarely reported. sodium arsenite 93-99 microRNA 21 Homo sapiens 21-27 35298964-5 2022 However, the role of miR-21 in the mitochondrial pathway of cervical cancer cells induced by NaAsO2 through NF-kappaB/GCLC and GSH synthesis regulated oxidative stress is rarely reported. sodium arsenite 93-99 nuclear factor kappa B subunit 1 Homo sapiens 108-117 35298964-5 2022 However, the role of miR-21 in the mitochondrial pathway of cervical cancer cells induced by NaAsO2 through NF-kappaB/GCLC and GSH synthesis regulated oxidative stress is rarely reported. sodium arsenite 93-99 glutamate-cysteine ligase catalytic subunit Homo sapiens 118-122 35298964-6 2022 Therefore, the purpose of this study was to investigate whether NaAsO2 might induce mitochondrial damage and apoptosis of cervical cancer cells through NF-kappaB/ miR-21 /GCLC induced oxidative stress, and play the anti-tumor role of arsenic as a potential drug for the treatment of cervical cancer. sodium arsenite 64-70 nuclear factor kappa B subunit 1 Homo sapiens 152-161 35298964-6 2022 Therefore, the purpose of this study was to investigate whether NaAsO2 might induce mitochondrial damage and apoptosis of cervical cancer cells through NF-kappaB/ miR-21 /GCLC induced oxidative stress, and play the anti-tumor role of arsenic as a potential drug for the treatment of cervical cancer. sodium arsenite 64-70 microRNA 21 Homo sapiens 163-169 35298964-6 2022 Therefore, the purpose of this study was to investigate whether NaAsO2 might induce mitochondrial damage and apoptosis of cervical cancer cells through NF-kappaB/ miR-21 /GCLC induced oxidative stress, and play the anti-tumor role of arsenic as a potential drug for the treatment of cervical cancer. sodium arsenite 64-70 glutamate-cysteine ligase catalytic subunit Homo sapiens 171-175 35298964-9 2022 RESULTS: Compared with the control group, with the gradual increasing dose of NaAsO2, cell viability was considerable reduced, and increased rate of apoptosis, intracellular GSH level was decreased significantly, ROS was increased, mitochondrial structure was damaged, mitochondrial membrane potential DeltaPsim and Bcl2/BAX lowered, the expression of Caspase3 and cleaved-caspase3 were significantly increased, resulting in mitochondrial apoptosis. sodium arsenite 78-84 BCL2 apoptosis regulator Homo sapiens 316-320 35298964-9 2022 RESULTS: Compared with the control group, with the gradual increasing dose of NaAsO2, cell viability was considerable reduced, and increased rate of apoptosis, intracellular GSH level was decreased significantly, ROS was increased, mitochondrial structure was damaged, mitochondrial membrane potential DeltaPsim and Bcl2/BAX lowered, the expression of Caspase3 and cleaved-caspase3 were significantly increased, resulting in mitochondrial apoptosis. sodium arsenite 78-84 BCL2 associated X, apoptosis regulator Homo sapiens 321-324 35298964-9 2022 RESULTS: Compared with the control group, with the gradual increasing dose of NaAsO2, cell viability was considerable reduced, and increased rate of apoptosis, intracellular GSH level was decreased significantly, ROS was increased, mitochondrial structure was damaged, mitochondrial membrane potential DeltaPsim and Bcl2/BAX lowered, the expression of Caspase3 and cleaved-caspase3 were significantly increased, resulting in mitochondrial apoptosis. sodium arsenite 78-84 caspase 3 Homo sapiens 352-360 35298964-10 2022 When Hela cells were treated with 15, 20, and 25 mumol/L NaAsO2, the mRNA and protein levels of GCLC and GCLM were reduced, the expression of p65 in the nucleus was increased, the expression of p-p65/p65, p-IkappaBalpha/IkappaBalpha and miR-21 were significantly increased. sodium arsenite 57-63 glutamate-cysteine ligase catalytic subunit Homo sapiens 96-100 35298964-10 2022 When Hela cells were treated with 15, 20, and 25 mumol/L NaAsO2, the mRNA and protein levels of GCLC and GCLM were reduced, the expression of p65 in the nucleus was increased, the expression of p-p65/p65, p-IkappaBalpha/IkappaBalpha and miR-21 were significantly increased. sodium arsenite 57-63 glutamate-cysteine ligase modifier subunit Homo sapiens 105-109 35298964-10 2022 When Hela cells were treated with 15, 20, and 25 mumol/L NaAsO2, the mRNA and protein levels of GCLC and GCLM were reduced, the expression of p65 in the nucleus was increased, the expression of p-p65/p65, p-IkappaBalpha/IkappaBalpha and miR-21 were significantly increased. sodium arsenite 57-63 RELA proto-oncogene, NF-kB subunit Homo sapiens 142-145 35298964-10 2022 When Hela cells were treated with 15, 20, and 25 mumol/L NaAsO2, the mRNA and protein levels of GCLC and GCLM were reduced, the expression of p65 in the nucleus was increased, the expression of p-p65/p65, p-IkappaBalpha/IkappaBalpha and miR-21 were significantly increased. sodium arsenite 57-63 RELA proto-oncogene, NF-kB subunit Homo sapiens 194-219 35298964-10 2022 When Hela cells were treated with 15, 20, and 25 mumol/L NaAsO2, the mRNA and protein levels of GCLC and GCLM were reduced, the expression of p65 in the nucleus was increased, the expression of p-p65/p65, p-IkappaBalpha/IkappaBalpha and miR-21 were significantly increased. sodium arsenite 57-63 NFKB inhibitor alpha Homo sapiens 220-232 35298964-10 2022 When Hela cells were treated with 15, 20, and 25 mumol/L NaAsO2, the mRNA and protein levels of GCLC and GCLM were reduced, the expression of p65 in the nucleus was increased, the expression of p-p65/p65, p-IkappaBalpha/IkappaBalpha and miR-21 were significantly increased. sodium arsenite 57-63 microRNA 21 Homo sapiens 237-243 35298964-11 2022 When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased. sodium arsenite 44-50 glutamate-cysteine ligase catalytic subunit Homo sapiens 54-58 35298964-11 2022 When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased. sodium arsenite 44-50 BCL2 apoptosis regulator Homo sapiens 117-122 35298964-11 2022 When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased. sodium arsenite 44-50 BCL2 associated X, apoptosis regulator Homo sapiens 123-126 35298964-11 2022 When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased. sodium arsenite 44-50 caspase 3 Homo sapiens 128-136 35298964-11 2022 When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased. sodium arsenite 74-80 glutamate-cysteine ligase catalytic subunit Homo sapiens 54-58 35298964-11 2022 When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased. sodium arsenite 74-80 BCL2 apoptosis regulator Homo sapiens 117-122 35298964-11 2022 When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased. sodium arsenite 74-80 BCL2 associated X, apoptosis regulator Homo sapiens 123-126 35298964-11 2022 When BSO increased the inhibitory effect of NaAsO2 on GCLC, Compared with NaAsO2 group, the DeltaPsim and protein of Bcl-2/BAX, caspase3 and cleaved-capsase3 were increased. sodium arsenite 74-80 caspase 3 Homo sapiens 128-136 35298964-12 2022 When BAY 11-7082 combined with NaAsO2 co-treated, compared with the NaAsO2 group, the protein and mRNA expression of GCLC was increased, NaAsO2-increased expression level of miR-21 was suppressed, and the DeltaPsim and cell viability were higher. sodium arsenite 31-37 glutamate-cysteine ligase catalytic subunit Homo sapiens 117-121 35298964-12 2022 When BAY 11-7082 combined with NaAsO2 co-treated, compared with the NaAsO2 group, the protein and mRNA expression of GCLC was increased, NaAsO2-increased expression level of miR-21 was suppressed, and the DeltaPsim and cell viability were higher. sodium arsenite 31-37 microRNA 21 Homo sapiens 174-180 35298964-12 2022 When BAY 11-7082 combined with NaAsO2 co-treated, compared with the NaAsO2 group, the protein and mRNA expression of GCLC was increased, NaAsO2-increased expression level of miR-21 was suppressed, and the DeltaPsim and cell viability were higher. sodium arsenite 68-74 glutamate-cysteine ligase catalytic subunit Homo sapiens 117-121 35298964-12 2022 When BAY 11-7082 combined with NaAsO2 co-treated, compared with the NaAsO2 group, the protein and mRNA expression of GCLC was increased, NaAsO2-increased expression level of miR-21 was suppressed, and the DeltaPsim and cell viability were higher. sodium arsenite 137-143 microRNA 21 Homo sapiens 174-180 35298964-13 2022 In addition, compared with the combination of NaAsO2 and miR-21NC, the protein expression of GCLC was increased, the DeltaPsim and cell viability reduction were alleviated by miR-21 Inhibitor combined with NaAsO2. sodium arsenite 46-52 glutamate-cysteine ligase catalytic subunit Homo sapiens 93-97 35298964-13 2022 In addition, compared with the combination of NaAsO2 and miR-21NC, the protein expression of GCLC was increased, the DeltaPsim and cell viability reduction were alleviated by miR-21 Inhibitor combined with NaAsO2. sodium arsenite 46-52 microRNA 21 Homo sapiens 175-181 35298964-13 2022 In addition, compared with the combination of NaAsO2 and miR-21NC, the protein expression of GCLC was increased, the DeltaPsim and cell viability reduction were alleviated by miR-21 Inhibitor combined with NaAsO2. sodium arsenite 206-212 microRNA 21 Homo sapiens 57-63 35298964-13 2022 In addition, compared with the combination of NaAsO2 and miR-21NC, the protein expression of GCLC was increased, the DeltaPsim and cell viability reduction were alleviated by miR-21 Inhibitor combined with NaAsO2. sodium arsenite 206-212 glutamate-cysteine ligase catalytic subunit Homo sapiens 93-97 35320977-0 2022 The Molecular Mechanism of Hepatic Lipid Metabolism Disorder Caused by NaAsO2 through Regulating the ERK/PPAR Signaling Pathway. sodium arsenite 71-77 Eph receptor B1 Rattus norvegicus 101-104 35320977-0 2022 The Molecular Mechanism of Hepatic Lipid Metabolism Disorder Caused by NaAsO2 through Regulating the ERK/PPAR Signaling Pathway. sodium arsenite 71-77 peroxisome proliferator activated receptor alpha Rattus norvegicus 105-109 35124219-4 2022 In addition, we confirmed that RBFOX2-C. showed a significantly stronger localization into stress granules than RBFOX2-N.C. upon sodium arsenite treatment. sodium arsenite 129-144 RNA binding fox-1 homolog 2 Homo sapiens 31-37 35124219-4 2022 In addition, we confirmed that RBFOX2-C. showed a significantly stronger localization into stress granules than RBFOX2-N.C. upon sodium arsenite treatment. sodium arsenite 129-144 RNA binding fox-1 homolog 2 Homo sapiens 112-118 35237411-4 2022 However, the mechanism underlying the involvement of PINK1/Parkin in NaAsO2-induced mitophagy is unclear. sodium arsenite 69-75 PTEN induced kinase 1 Rattus norvegicus 53-58 35237411-8 2022 The successful KD of PINK1 and Parkin aggravated the NaAsO2-induced damage to mitophagy. sodium arsenite 53-59 PTEN induced kinase 1 Rattus norvegicus 21-26 35237411-9 2022 The degeneration of mitochondrial vacuoles and the appearance of autophagosomes were detected in the NaAsO2, NaAsO2 + PINK1-KD and NaAsO2 + Parkin-KD groups. sodium arsenite 109-115 PTEN induced kinase 1 Rattus norvegicus 118-123 35237411-10 2022 NaAsO2 can induce mitophagy in rat hepatocytes, and the silencing of PINK1 and Parkin can aggravate mitochondrial damage during this process. sodium arsenite 0-6 PTEN induced kinase 1 Rattus norvegicus 69-74 2777774-1 1989 Platelet-derived growth factor (PDGF), fibroblast growth factor, and heavy metal salts such as sodium arsenite stimulated BALB/c-3T3 cells to synthesize a 31-kDa protein(s) (termed p31) in a concentration-dependent manner. sodium arsenite 95-110 ATPase, H+ transporting, lysosomal V1 subunit E1 Mus musculus 181-184 2484616-4 1989 We now confirm the nonmutagenicity of sodium arsenite in line G12, a pSV2gpt-transformed V79 (hprt-) cell line, which is able to detect multilocus deletions in addition to point mutations and small deletions. sodium arsenite 38-53 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 94-98 2484616-6 1989 Sodium arsenite at relatively nontoxic concentrations (5 microM for 24 h or 10 microM for 3 h) is comutagenic with N-methyl-N-nitrosourea (MMU) at the hprt locus in V79 cells. sodium arsenite 0-15 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 151-155 2484623-12 1989 Both sodium arsenite and sodium arsenate induced a high frequency of methotrexate-resistant 3T6 cells, which were shown to have amplified copies of the dihydrofolate reductase gene. sodium arsenite 5-20 dihydrofolate reductase Mus musculus 152-175 2791215-0 1989 Effect of sodium arsenite on the induction and turnover of ornithine decarboxylase activity in erythroleukemia cells. sodium arsenite 10-25 ornithine decarboxylase 1 Homo sapiens 59-82 2791215-1 1989 Sodium arsenite proved effective in preventing the induction of ornithine decarboxylase (ODC) activity elicited by dilution of Friend erythroleukemia cells in fresh medium. sodium arsenite 0-15 ornithine decarboxylase 1 Homo sapiens 64-87 2791215-1 1989 Sodium arsenite proved effective in preventing the induction of ornithine decarboxylase (ODC) activity elicited by dilution of Friend erythroleukemia cells in fresh medium. sodium arsenite 0-15 ornithine decarboxylase 1 Homo sapiens 89-92 2791215-4 1989 The half-life of ODC activity, measured after cycloheximide treatment, increased almost six-fold after addition of sodium arsenite. sodium arsenite 115-130 ornithine decarboxylase 1 Homo sapiens 17-20