PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32145316-4	2020	Therefore, this report investigated the potential inhibitory effects of paris saponin I, II, VII and polyphyllin VI on the activities of CYP (CYP1A2, CYP2B1, CYP2C11, CYP2D1, CYP2E1 and CYP3A2) and UGT (UGT1A1, UGT1A3, UGT1A6, PROG and AZTG) through cocktail inhibition assays in vitro.	Polyphyllin VI	101-115	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	137-140
32145316-4	2020	Therefore, this report investigated the potential inhibitory effects of paris saponin I, II, VII and polyphyllin VI on the activities of CYP (CYP1A2, CYP2B1, CYP2C11, CYP2D1, CYP2E1 and CYP3A2) and UGT (UGT1A1, UGT1A3, UGT1A6, PROG and AZTG) through cocktail inhibition assays in vitro.	Polyphyllin VI	101-115	cytochrome P450, subfamily 2, polypeptide 11	Rattus norvegicus	158-165
32145316-4	2020	Therefore, this report investigated the potential inhibitory effects of paris saponin I, II, VII and polyphyllin VI on the activities of CYP (CYP1A2, CYP2B1, CYP2C11, CYP2D1, CYP2E1 and CYP3A2) and UGT (UGT1A1, UGT1A3, UGT1A6, PROG and AZTG) through cocktail inhibition assays in vitro.	Polyphyllin VI	101-115	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	167-173
32145316-4	2020	Therefore, this report investigated the potential inhibitory effects of paris saponin I, II, VII and polyphyllin VI on the activities of CYP (CYP1A2, CYP2B1, CYP2C11, CYP2D1, CYP2E1 and CYP3A2) and UGT (UGT1A1, UGT1A3, UGT1A6, PROG and AZTG) through cocktail inhibition assays in vitro.	Polyphyllin VI	101-115	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	175-181
32145316-5	2020	In the study of CYP, polyphyllin VI exhibited weak inhibition on CYP2D1 activity in rat liver microsomes with IC50 value at 45.2 muM, while paris saponin VII weakly inhibited CYP2C11 and CYP2E1 activities with IC50 value at 42.0 and 67.7 muM, respectively.	Polyphyllin VI	21-35	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	16-19
32145316-5	2020	In the study of CYP, polyphyllin VI exhibited weak inhibition on CYP2D1 activity in rat liver microsomes with IC50 value at 45.2 muM, while paris saponin VII weakly inhibited CYP2C11 and CYP2E1 activities with IC50 value at 42.0 and 67.7 muM, respectively.	Polyphyllin VI	21-35	cytochrome P450, family 2, subfamily d, polypeptide 1	Rattus norvegicus	65-71
30817902-0	2019	Targeted regulation of Rell2 by microRNA-18a is implicated in the anti-metastatic effect of polyphyllin VI in breast cancer cells.	Polyphyllin VI	92-106	RELT like 2	Homo sapiens	23-28
32214827-0	2020	Polyphyllin VI Induces Apoptosis and Autophagy via Reactive Oxygen Species Mediated JNK and P38 Activation in Glioma.	Polyphyllin VI	0-14	mitogen-activated protein kinase 8	Mus musculus	84-87
32214827-0	2020	Polyphyllin VI Induces Apoptosis and Autophagy via Reactive Oxygen Species Mediated JNK and P38 Activation in Glioma.	Polyphyllin VI	0-14	mitogen-activated protein kinase 14	Mus musculus	92-95
31695327-0	2019	Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation.	Polyphyllin VI	0-14	mitogen-activated protein kinase 8	Homo sapiens	96-99
31695327-5	2019	The Polyphyllin VI-induced apoptosis was determined by Annexin V-APC/7-AAD apoptosis detection kit and JC-1 staining.	Polyphyllin VI	4-18	annexin A5	Homo sapiens	55-64
31695327-5	2019	The Polyphyllin VI-induced apoptosis was determined by Annexin V-APC/7-AAD apoptosis detection kit and JC-1 staining.	Polyphyllin VI	4-18	anaphase promoting complex subunit 7	Homo sapiens	65-70
31695327-10	2019	Polyphyllin VI induced mitochondria-mediated apoptosis with the upregulation of proapoptotic proteins Bax and poly ADP-ribose polymerase, and downregulation of antiapoptotic protein Bcl-2 in U2OS cells.	Polyphyllin VI	0-14	BCL2 associated X, apoptosis regulator	Homo sapiens	102-105
31695327-10	2019	Polyphyllin VI induced mitochondria-mediated apoptosis with the upregulation of proapoptotic proteins Bax and poly ADP-ribose polymerase, and downregulation of antiapoptotic protein Bcl-2 in U2OS cells.	Polyphyllin VI	0-14	poly(ADP-ribose) polymerase 1	Homo sapiens	110-136
31695327-10	2019	Polyphyllin VI induced mitochondria-mediated apoptosis with the upregulation of proapoptotic proteins Bax and poly ADP-ribose polymerase, and downregulation of antiapoptotic protein Bcl-2 in U2OS cells.	Polyphyllin VI	0-14	BCL2 apoptosis regulator	Homo sapiens	182-187
31695327-13	2019	Polyphyllin VI dramatically promoted JNK phosphorylation, whereas it decreased the levels of phospho-p38 and ERK.	Polyphyllin VI	0-14	mitogen-activated protein kinase 8	Homo sapiens	37-40
31695327-13	2019	Polyphyllin VI dramatically promoted JNK phosphorylation, whereas it decreased the levels of phospho-p38 and ERK.	Polyphyllin VI	0-14	mitogen-activated protein kinase 14	Homo sapiens	101-104
31695327-13	2019	Polyphyllin VI dramatically promoted JNK phosphorylation, whereas it decreased the levels of phospho-p38 and ERK.	Polyphyllin VI	0-14	mitogen-activated protein kinase 1	Homo sapiens	109-112
31695327-14	2019	Conclusion: Our results reveal that Polyphyllin VI may effectively induce apoptosis and autophagy to suppress cell growth via ROS/JNK activation in U2OS cells, suggesting that Polyphyllin VI is a potential drug candidate for the treatment of osteosarcomas.	Polyphyllin VI	36-50	mitogen-activated protein kinase 8	Homo sapiens	130-133
31695327-14	2019	Conclusion: Our results reveal that Polyphyllin VI may effectively induce apoptosis and autophagy to suppress cell growth via ROS/JNK activation in U2OS cells, suggesting that Polyphyllin VI is a potential drug candidate for the treatment of osteosarcomas.	Polyphyllin VI	176-190	mitogen-activated protein kinase 8	Homo sapiens	130-133
29762502-4	2018	Flow cytometric assay displayed that polyphyllin VI promoted the generation of reactive oxygen species (ROS), depolarized the mitochondrial membrane potential (MMP), and induced S phase cell cycle arrest by decreasing the expression of cyclin A2 and CDK2, while significantly increasing the expression of p21 protein.	Polyphyllin VI	37-51	cyclin A2	Homo sapiens	236-245
29762502-4	2018	Flow cytometric assay displayed that polyphyllin VI promoted the generation of reactive oxygen species (ROS), depolarized the mitochondrial membrane potential (MMP), and induced S phase cell cycle arrest by decreasing the expression of cyclin A2 and CDK2, while significantly increasing the expression of p21 protein.	Polyphyllin VI	37-51	cyclin dependent kinase 2	Homo sapiens	250-254
29762502-4	2018	Flow cytometric assay displayed that polyphyllin VI promoted the generation of reactive oxygen species (ROS), depolarized the mitochondrial membrane potential (MMP), and induced S phase cell cycle arrest by decreasing the expression of cyclin A2 and CDK2, while significantly increasing the expression of p21 protein.	Polyphyllin VI	37-51	H3 histone pseudogene 16	Homo sapiens	305-308
29762502-5	2018	Polyphyllin VI induced the release of cytochrome c from the mitochondria to the cytosol and activated Fas, caspase-3, -8, -9, and PARP proteins.	Polyphyllin VI	0-14	cytochrome c, somatic	Homo sapiens	38-50
29762502-5	2018	Polyphyllin VI induced the release of cytochrome c from the mitochondria to the cytosol and activated Fas, caspase-3, -8, -9, and PARP proteins.	Polyphyllin VI	0-14	caspase 3	Homo sapiens	107-124
29762502-5	2018	Polyphyllin VI induced the release of cytochrome c from the mitochondria to the cytosol and activated Fas, caspase-3, -8, -9, and PARP proteins.	Polyphyllin VI	0-14	collagen type XI alpha 2 chain	Homo sapiens	130-134
29762502-6	2018	Pretreatment with NAC and Z-VAD-FMK (ROS scavenger and caspase inhibitor, respectively) on HepaRG cells increased the percentage of viable cells, which indicated that polyphyllin VI induced cell apoptosis through mitochondrial pathway by the generation of ROS and Fas death-dependent pathway.	Polyphyllin VI	167-181	synuclein alpha	Homo sapiens	18-21