PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 28359180-12 2018 In conclusion, GFJ could increase the systemic exposure of triptolide in rats, when GFJ and triptolide was coadministered, and it might work mainly through increasing the absorption of triptolide by inhibiting P-gp, or through slowing down the metabolism of triptolide in rat liver by inhibiting the activity of CYP3A4. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 15-18 phosphoglycolate phosphatase Rattus norvegicus 210-214 32347580-2 2020 The results showed that GFJ significantly (p < .05) inhibit the serum and hepatic xanthine oxidase enzyme, lower uric acid level, serum creatinine, uromodulin, and blood urea nitrogen levels to normal and lower inflammation related genes IL-1beta, caspase-1, NLRP3, and ASC. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 24-27 xanthine dehydrogenase Mus musculus 82-98 32347580-2 2020 The results showed that GFJ significantly (p < .05) inhibit the serum and hepatic xanthine oxidase enzyme, lower uric acid level, serum creatinine, uromodulin, and blood urea nitrogen levels to normal and lower inflammation related genes IL-1beta, caspase-1, NLRP3, and ASC. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 24-27 interleukin 1 alpha Mus musculus 238-246 32347580-2 2020 The results showed that GFJ significantly (p < .05) inhibit the serum and hepatic xanthine oxidase enzyme, lower uric acid level, serum creatinine, uromodulin, and blood urea nitrogen levels to normal and lower inflammation related genes IL-1beta, caspase-1, NLRP3, and ASC. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 24-27 caspase 1 Mus musculus 248-257 32347580-2 2020 The results showed that GFJ significantly (p < .05) inhibit the serum and hepatic xanthine oxidase enzyme, lower uric acid level, serum creatinine, uromodulin, and blood urea nitrogen levels to normal and lower inflammation related genes IL-1beta, caspase-1, NLRP3, and ASC. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 24-27 NLR family, pyrin domain containing 3 Mus musculus 259-264 32347580-2 2020 The results showed that GFJ significantly (p < .05) inhibit the serum and hepatic xanthine oxidase enzyme, lower uric acid level, serum creatinine, uromodulin, and blood urea nitrogen levels to normal and lower inflammation related genes IL-1beta, caspase-1, NLRP3, and ASC. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 24-27 steroid sulfatase Mus musculus 270-273 32347580-5 2020 The results of immunohistochemistry revealed that the ABCG2 protein expression in the small and large intestine was significantly upregulated after the GFJ administration. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 152-155 ATP binding cassette subfamily G member 2 (Junior blood group) Mus musculus 54-59 26889365-7 2015 Also western blotting was employed to evaluate the effect of GFJ on Bax:Bcl-2 ratio. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 61-64 BCL2 associated X, apoptosis regulator Homo sapiens 68-71 26889365-7 2015 Also western blotting was employed to evaluate the effect of GFJ on Bax:Bcl-2 ratio. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 61-64 BCL2 apoptosis regulator Homo sapiens 72-77 26889365-11 2015 Consistently, after treating KB cells with GFJ(1mug/mL), caspase-3 activity and Bax:Bcl-2 ratio were raised by 7.3+-0.6 and (P <0.001) folds, respectively. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 43-46 caspase 3 Homo sapiens 57-66 26889365-11 2015 Consistently, after treating KB cells with GFJ(1mug/mL), caspase-3 activity and Bax:Bcl-2 ratio were raised by 7.3+-0.6 and (P <0.001) folds, respectively. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 43-46 BCL2 associated X, apoptosis regulator Homo sapiens 80-83 26889365-11 2015 Consistently, after treating KB cells with GFJ(1mug/mL), caspase-3 activity and Bax:Bcl-2 ratio were raised by 7.3+-0.6 and (P <0.001) folds, respectively. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 43-46 BCL2 apoptosis regulator Homo sapiens 84-89 26889365-13 2015 The results of this study advanced that GFJ induces apoptosis in the KB cells through increasing caspase-3 activity and Bax:Bcl2 ratio which could be attributed to its organo-sulfurcomponents. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 40-43 caspase 3 Homo sapiens 97-106 26889365-13 2015 The results of this study advanced that GFJ induces apoptosis in the KB cells through increasing caspase-3 activity and Bax:Bcl2 ratio which could be attributed to its organo-sulfurcomponents. 4-[1-(5,8-difluoroquinolin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzimidazol-6-yl]-3-fluoropyridin-2-amine 40-43 BCL2 associated X, apoptosis regulator Homo sapiens 120-123