PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 35507739-0 2022 Maralixibat for the treatment of PFIC: Long-term, IBAT inhibition in an open-label, Phase 2 study. Lopixibat 0-11 solute carrier family 10 member 2 Homo sapiens 50-54 29284646-6 2018 We report a multidrug regimen of 4-phenylbutyrate, oxcarbazepine, and maralixibat (an experimental drug owned by Shire Pharmaceuticals, Dublin, Republic of Ireland) that completely controlled symptoms in 2 siblings with partial loss of BSEP activity. Lopixibat 70-81 ATP binding cassette subfamily B member 11 Homo sapiens 236-240 32653991-9 2020 The clinical programs of 2 IBAT inhibitors in development for the treatment of pediatric cholestatic liver diseases, maralixibat and odevixibat, are highlighted. Lopixibat 117-128 solute carrier family 10 member 2 Homo sapiens 27-31 35507739-3 2022 INDIGO was an open-label, Phase 2, international, long-term study to assess the efficacy and safety of maralixibat in children with FIC1 or BSEP deficiencies. Lopixibat 103-114 ATPase phospholipid transporting 8B1 Homo sapiens 132-136 35507739-3 2022 INDIGO was an open-label, Phase 2, international, long-term study to assess the efficacy and safety of maralixibat in children with FIC1 or BSEP deficiencies. Lopixibat 103-114 ATP binding cassette subfamily B member 11 Homo sapiens 140-144 34813049-1 2022 Maralixibat (Livmarli ) is an orally-administered, small-molecule ileal bile acid transporter (IBAT) inhibitor being developed by Mirum Pharmaceuticals for the treatment of rare cholestatic liver diseases including Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC) and biliary atresia. Lopixibat 0-11 solute carrier family 10 member 2 Homo sapiens 95-99 34813049-1 2022 Maralixibat (Livmarli ) is an orally-administered, small-molecule ileal bile acid transporter (IBAT) inhibitor being developed by Mirum Pharmaceuticals for the treatment of rare cholestatic liver diseases including Alagille syndrome (ALGS), progressive familial intrahepatic cholestasis (PFIC) and biliary atresia. Lopixibat 0-11 ATPase phospholipid transporting 8B1 Homo sapiens 288-292