PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31325047-0	2019	20(S)-hydroxycholesterol and simvastatin synergistically enhance osteogenic differentiation of marrow stromal cells and bone regeneration by initiation of Raf/MEK/ERK signaling.	20-hydroxycholesterol	0-24	mitogen-activated protein kinase kinase 7	Homo sapiens	159-162
31325047-0	2019	20(S)-hydroxycholesterol and simvastatin synergistically enhance osteogenic differentiation of marrow stromal cells and bone regeneration by initiation of Raf/MEK/ERK signaling.	20-hydroxycholesterol	0-24	mitogen-activated protein kinase 1	Homo sapiens	163-166
30691220-4	2019	This study aimed to validate the DPP-4 inhibitory activity of clerodane diterpene 16-hydroxycleroda-3,13-dien-15,16-olide (HCD) from Polyalthia longifolia, rutin, quercetin, and berberine, previously selected through molecular docking.	20-hydroxycholesterol	123-126	dipeptidyl peptidase 4	Homo sapiens	33-38
28498352-5	2017	Extended experiments of anti-diabetic efficacy confirmed HCD biocompatible with mesoporous silica nanoparticles (MSNs) encapsulation resulted in a sustained release property in delivering HCD for the inhibition of DPP4 via the activity and protein levels of DPP4 analysis.	20-hydroxycholesterol	57-60	dipeptidylpeptidase 4	Mus musculus	214-218
28498352-5	2017	Extended experiments of anti-diabetic efficacy confirmed HCD biocompatible with mesoporous silica nanoparticles (MSNs) encapsulation resulted in a sustained release property in delivering HCD for the inhibition of DPP4 via the activity and protein levels of DPP4 analysis.	20-hydroxycholesterol	57-60	dipeptidylpeptidase 4	Mus musculus	258-262
28193578-5	2017	Liquid chromatography-tandem mass spectrometry-based proteomic analysis and Ingenuity Pathway Analysis showed that HCD consumption altered IL-6 signaling pathway proteins (PI3KR4, IL-1alpha, Mapk10, Akt3, PIK3CG, PIK3R5, Map2k2).	20-hydroxycholesterol	115-118	interleukin-6	Sus scrofa	139-143
28193578-5	2017	Liquid chromatography-tandem mass spectrometry-based proteomic analysis and Ingenuity Pathway Analysis showed that HCD consumption altered IL-6 signaling pathway proteins (PI3KR4, IL-1alpha, Mapk10, Akt3, PIK3CG, PIK3R5, Map2k2).	20-hydroxycholesterol	115-118	interleukin 1 alpha	Sus scrofa	180-189
28193578-5	2017	Liquid chromatography-tandem mass spectrometry-based proteomic analysis and Ingenuity Pathway Analysis showed that HCD consumption altered IL-6 signaling pathway proteins (PI3KR4, IL-1alpha, Mapk10, Akt3, PIK3CG, PIK3R5, Map2k2).	20-hydroxycholesterol	115-118	mitogen-activated protein kinase 10	Sus scrofa	191-197
28193578-5	2017	Liquid chromatography-tandem mass spectrometry-based proteomic analysis and Ingenuity Pathway Analysis showed that HCD consumption altered IL-6 signaling pathway proteins (PI3KR4, IL-1alpha, Mapk10, Akt3, PIK3CG, PIK3R5, Map2k2).	20-hydroxycholesterol	115-118	protein kinase B gamma	Sus scrofa	199-203
28193578-5	2017	Liquid chromatography-tandem mass spectrometry-based proteomic analysis and Ingenuity Pathway Analysis showed that HCD consumption altered IL-6 signaling pathway proteins (PI3KR4, IL-1alpha, Mapk10, Akt3, PIK3CG, PIK3R5, Map2k2).	20-hydroxycholesterol	115-118	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Sus scrofa	205-211
28193578-5	2017	Liquid chromatography-tandem mass spectrometry-based proteomic analysis and Ingenuity Pathway Analysis showed that HCD consumption altered IL-6 signaling pathway proteins (PI3KR4, IL-1alpha, Mapk10, Akt3, PIK3CG, PIK3R5, Map2k2).	20-hydroxycholesterol	115-118	phosphoinositide-3-kinase regulatory subunit 5	Sus scrofa	213-219
28193578-5	2017	Liquid chromatography-tandem mass spectrometry-based proteomic analysis and Ingenuity Pathway Analysis showed that HCD consumption altered IL-6 signaling pathway proteins (PI3KR4, IL-1alpha, Mapk10, Akt3, PIK3CG, PIK3R5, Map2k2).	20-hydroxycholesterol	115-118	mitogen-activated protein kinase kinase 2	Sus scrofa	221-227
23773725-5	2013	RESULTS: Rutin in combination with HCD induced a significant protective effect against the hepatotoxicity by reducing the plasma level of alanine transaminase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL).	20-hydroxycholesterol	35-38	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	166-192
27383590-4	2016	As expected, male and female neuron-specific SOCS3 knock-out mice were protected from HCD-induced obesity.	20-hydroxycholesterol	86-89	suppressor of cytokine signaling 3	Mus musculus	45-50
27318969-2	2016	This study further attempted to investigate the involvement of HCD-induced autophagy in brain tumor cell lines neuroblastoma N18 and glioma C6 through the induction of reactive oxygen species (ROS) and the activation of p38 and ERK-1/2 pathway.	20-hydroxycholesterol	63-66	mitogen-activated protein kinase 1	Homo sapiens	220-223
27318969-2	2016	This study further attempted to investigate the involvement of HCD-induced autophagy in brain tumor cell lines neuroblastoma N18 and glioma C6 through the induction of reactive oxygen species (ROS) and the activation of p38 and ERK-1/2 pathway.	20-hydroxycholesterol	63-66	mitogen-activated protein kinase 3	Homo sapiens	228-235
26851441-6	2016	When compared with the control and pure HCD, the MSN-HCD revealed a potential anti-proliferation effect via the synergistic effect of the drug and the MSN vehicle.	20-hydroxycholesterol	40-43	moesin	Mus musculus	49-52
26851441-9	2016	In terms of the effective treatment of brain glioma, this study provides conclusive evidence of the successful development of the anti-cancer agent HCD conjugated with enteric-coated MSN as a delivery control mechanism with enhanced dissolution characteristics.	20-hydroxycholesterol	148-151	moesin	Mus musculus	183-186
25823019-7	2015	The expression levels of ABCA1, apoA1, PON1 and PPARalpha were found to be significantly increased in NjRBO-treated group compared with the HCD-fed group; however, the expression level of apoB was found to be higher in HCD-fed group and lower in the NjRBO-treated group.	20-hydroxycholesterol	140-143	apolipoprotein B	Rattus norvegicus	188-192
27318969-5	2016	Additionally, HCD was found to significantly induce p-p38 MAPK and p-ERK-1/2 proteins by Western blot, which implies that HCD is a potential therapeutic anticancer agent that exerts its activity through inducing ROS-mediation for the autophagy of brain tumor cells.	20-hydroxycholesterol	14-17	mitogen-activated protein kinase 1	Homo sapiens	54-57
27318969-5	2016	Additionally, HCD was found to significantly induce p-p38 MAPK and p-ERK-1/2 proteins by Western blot, which implies that HCD is a potential therapeutic anticancer agent that exerts its activity through inducing ROS-mediation for the autophagy of brain tumor cells.	20-hydroxycholesterol	14-17	mitogen-activated protein kinase 1	Homo sapiens	69-76
26671069-7	2015	AM251 reversed the HCD-inhibited expression of Glo1 and DLD in the muscle, and the DLD and CB1 receptor expression in the mitochondrial fraction.	20-hydroxycholesterol	19-22	glyoxalase 1	Rattus norvegicus	47-51
25964052-7	2015	Further analysis showed that ApoE KO mice chronically fed with HCD had increased levels of total cholesterol, low-density lipoprotein in the blood and counts and percentages of circulating monocytes compared with ApoE KO mice fed with a normal diet.	20-hydroxycholesterol	63-66	apolipoprotein E	Mus musculus	29-33
23628706-8	2013	Zymography showed that HCD inhibited the activity of MMP-2 and MMP-9.	20-hydroxycholesterol	23-26	matrix metallopeptidase 2	Homo sapiens	53-58
23628706-8	2013	Zymography showed that HCD inhibited the activity of MMP-2 and MMP-9.	20-hydroxycholesterol	23-26	matrix metallopeptidase 9	Homo sapiens	63-68
23628706-12	2013	GENERAL SIGNIFICANCE: This study suggests that HCD could be a potential inhibitor of FAK and could be used for anti-tumorigenesis and anti-metastasis treatments.	20-hydroxycholesterol	47-50	protein tyrosine kinase 2	Homo sapiens	85-88
23773725-5	2013	RESULTS: Rutin in combination with HCD induced a significant protective effect against the hepatotoxicity by reducing the plasma level of alanine transaminase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL).	20-hydroxycholesterol	35-38	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	194-197
22867714-13	2012	Activated endothelial nitric oxide synthase (eNOS) was increased in the HCD-R group (p = 0.01).	20-hydroxycholesterol	72-75	nitric oxide synthase 3	Sus scrofa	10-43
22500017-7	2012	Upon feeding a 2% high cholesterol diet (HCD), Ldlr-/-xLcat-/- mice accumulated a similar amount of total hepatic cholesterol compared with the Ldlr-/-xLcat+/+ mice, but the hepatic ER cholesterol levels remained low in conjunction with being protected from HCD-induced ER stress and IR.	20-hydroxycholesterol	41-44	low density lipoprotein receptor	Mus musculus	47-51
21575630-9	2011	Peroxisome proliferator-activated receptor gamma and retinol binding protein 4 were downregulated in the HCD-R group as compared to the HCD group.	20-hydroxycholesterol	105-108	peroxisome proliferator activated receptor gamma	Sus scrofa	0-48
21575630-9	2011	Peroxisome proliferator-activated receptor gamma and retinol binding protein 4 were downregulated in the HCD-R group as compared to the HCD group.	20-hydroxycholesterol	105-108	retinol binding protein 4	Sus scrofa	53-78
19265037-4	2009	Feeding an HCD supplemented with a fluorescent cholesteryl ester to optically transparent fli1:EGFP zebrafish larvae in which endothelial cells express green fluorescent protein (GFP), and using confocal microscopy enabled monitoring vascular lipid accumulation and the endothelial cell layer disorganization and thickening in a live animal.	20-hydroxycholesterol	11-14	Fli-1 proto-oncogene, ETS transcription factor	Danio rerio	90-94
21575630-9	2011	Peroxisome proliferator-activated receptor gamma and retinol binding protein 4 were downregulated in the HCD-R group as compared to the HCD group.	20-hydroxycholesterol	136-139	peroxisome proliferator activated receptor gamma	Sus scrofa	0-48
21575630-9	2011	Peroxisome proliferator-activated receptor gamma and retinol binding protein 4 were downregulated in the HCD-R group as compared to the HCD group.	20-hydroxycholesterol	136-139	retinol binding protein 4	Sus scrofa	53-78
21160531-7	2011	Indices of monocyte/macrophage (Mo/MPhi) accumulation, CD68, integrin, alpha M (ITGAM) and egf-like module containing, mucin-like, hormone receptor-like 1 (EMR-1), were reduced in hNetrin-1/HCD-treated animal"s aortas and spleens compared with Neo/HCD-treated animals.	20-hydroxycholesterol	190-193	adhesion G protein-coupled receptor E1	Homo sapiens	91-154
17307335-7	2007	These results demonstrate that hypoxic condition-and HCD-induced expression of Redd1 is mediated by coactivation of Sp1 and HIF-1alpha downstream of the PI3K/Akt signaling pathway.	20-hydroxycholesterol	53-56	DNA damage inducible transcript 4	Homo sapiens	79-84
17307335-7	2007	These results demonstrate that hypoxic condition-and HCD-induced expression of Redd1 is mediated by coactivation of Sp1 and HIF-1alpha downstream of the PI3K/Akt signaling pathway.	20-hydroxycholesterol	53-56	hypoxia inducible factor 1 subunit alpha	Homo sapiens	124-134
17307335-2	2007	In the present study, we demonstrated that the expression of Redd1 in response to hypoxia (1% O(2)), hypoxia-mimetic agent, cobalt chloride (CoCl(2)) and high cell density (HCD) requires coactivation of HIF-1alpha and Sp1.	20-hydroxycholesterol	173-176	DNA damage inducible transcript 4	Homo sapiens	61-66
17307335-7	2007	These results demonstrate that hypoxic condition-and HCD-induced expression of Redd1 is mediated by coactivation of Sp1 and HIF-1alpha downstream of the PI3K/Akt signaling pathway.	20-hydroxycholesterol	53-56	AKT serine/threonine kinase 1	Homo sapiens	158-161
17307335-3	2007	CoCl(2) and HCD induced the activation of HIF-1alpha and Sp1 in HeLa cells, and siRNAs targeting HIF-1alpha and Sp1 abrogated Redd1 expression.	20-hydroxycholesterol	12-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	42-52
17307335-3	2007	CoCl(2) and HCD induced the activation of HIF-1alpha and Sp1 in HeLa cells, and siRNAs targeting HIF-1alpha and Sp1 abrogated Redd1 expression.	20-hydroxycholesterol	12-15	DNA damage inducible transcript 4	Homo sapiens	126-131
17208374-7	2007	Then, the expression level of CB1 receptor significantly decreased in the HCD group, while that of the CR group clearly increased in comparison with the ND group in intact mice.	20-hydroxycholesterol	74-77	cannabinoid receptor 1 (brain)	Mus musculus	30-33
17307335-4	2007	Inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002 and by a dominant-negative PI3K mutant reduced the expression of Redd1 and activation of HIF-1alpha and Sp1 by CoCl(2) and HCD.	20-hydroxycholesterol	186-189	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	14-43
17307335-4	2007	Inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002 and by a dominant-negative PI3K mutant reduced the expression of Redd1 and activation of HIF-1alpha and Sp1 by CoCl(2) and HCD.	20-hydroxycholesterol	186-189	DNA damage inducible transcript 4	Homo sapiens	128-133
17307335-4	2007	Inhibition of phosphatidylinositol 3-kinase (PI3K) by LY294002 and by a dominant-negative PI3K mutant reduced the expression of Redd1 and activation of HIF-1alpha and Sp1 by CoCl(2) and HCD.	20-hydroxycholesterol	186-189	hypoxia inducible factor 1 subunit alpha	Homo sapiens	152-162
34162227-6	2021	Ex vivo studies further showed that VSMC-specific PGC1alpha overexpression markedly suppressed the promotive effect of HCD feeding on the association of serum response factor (SRF) with ELK1, a ternary complex factor (TCF) that acts as a myogenic repressor in VSMCs, thereby preserving the VSMC contractile phenotype.	20-hydroxycholesterol	119-122	PPARG coactivator 1 alpha	Homo sapiens	50-59
12540482-4	2003	We compared the abilities of ATH, covalent HC-heparin complex (HCH), and covalent HC-dermatan sulfate (HCD) to inhibit thrombin generation on FDLE in plasmas from either adults or newborns.	20-hydroxycholesterol	103-106	coagulation factor II	Rattus norvegicus	119-127
12540482-11	2003	In summary, ATH, HCH, and HCD are inhibitors of thrombin generation on FDLE superior to the corresponding noncovalent mixtures, with ATH and HCH being more potent than HCD.	20-hydroxycholesterol	26-29	coagulation factor II	Rattus norvegicus	48-56
34162227-6	2021	Ex vivo studies further showed that VSMC-specific PGC1alpha overexpression markedly suppressed the promotive effect of HCD feeding on the association of serum response factor (SRF) with ELK1, a ternary complex factor (TCF) that acts as a myogenic repressor in VSMCs, thereby preserving the VSMC contractile phenotype.	20-hydroxycholesterol	119-122	serum response factor	Oryctolagus cuniculus	153-174
34162227-6	2021	Ex vivo studies further showed that VSMC-specific PGC1alpha overexpression markedly suppressed the promotive effect of HCD feeding on the association of serum response factor (SRF) with ELK1, a ternary complex factor (TCF) that acts as a myogenic repressor in VSMCs, thereby preserving the VSMC contractile phenotype.	20-hydroxycholesterol	119-122	serum response factor	Oryctolagus cuniculus	176-179
34162227-6	2021	Ex vivo studies further showed that VSMC-specific PGC1alpha overexpression markedly suppressed the promotive effect of HCD feeding on the association of serum response factor (SRF) with ELK1, a ternary complex factor (TCF) that acts as a myogenic repressor in VSMCs, thereby preserving the VSMC contractile phenotype.	20-hydroxycholesterol	119-122	ETS domain-containing protein Elk-1	Oryctolagus cuniculus	186-190
34102259-7	2021	Specifically, HCD-TBT rats displayed irregular estrous cyclicity, high follicle-stimulating hormone (FSH) levels, low anti-Mullerian hormone (AMH) levels, reduction in ovarian reserve, and corpora lutea (CL) number, with increases in atretic follicles, suggesting that HCD-TBT exposure exacerbated POF features.	20-hydroxycholesterol	269-272	anti-Mullerian hormone	Rattus norvegicus	142-145
32150446-5	2020	An acute exercise study was performed to elucidate the effect of obesity, acute running and hCN1 overexpression on plasma HCD levels.	20-hydroxycholesterol	122-125	carnosine dipeptidase 1	Homo sapiens	92-96
34967909-3	2022	In this study, we were interested in exploring the role of protein tyrosine phosphatase 1B (PTP1B), which is a negative regulator of both leptin and insulin signaling, in the pathophysiology of HCD-induced obesity and infertility.	20-hydroxycholesterol	194-197	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	92-97
34967909-8	2022	These data show that neuronal PTP1B deletion is able to partially protect mice from HCD-induced obesity, but is not a critical mediator of HCD-induced infertility.	20-hydroxycholesterol	84-87	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	30-35
31392349-8	2020	The present study, for the first time, revealed the novel mechanism for lipophagy mediating HCD-induced changes of lipid metabolism by oxidative stress and ER stress, and ChREBP/PPARgamma pathways.	20-hydroxycholesterol	92-95	MLX interacting protein like	Homo sapiens	171-177
31392349-8	2020	The present study, for the first time, revealed the novel mechanism for lipophagy mediating HCD-induced changes of lipid metabolism by oxidative stress and ER stress, and ChREBP/PPARgamma pathways.	20-hydroxycholesterol	92-95	peroxisome proliferator activated receptor gamma	Homo sapiens	178-187