PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 32862147-5 2020 Moreover, concomitant treatment with a P-gp inhibitor, zosuquidar, increased the Kp,uu,lumbar CSF values of the good P-gp substrates, indicating that P-gp-mediated active efflux contributed to the low Kp,uu,lumbar CSF values of these compounds. UU 84-86 ATP binding cassette subfamily B member 1 Homo sapiens 39-43 34426410-11 2021 Significance Statement For the first time, using in vitro studies in cells, we successfully predicted human fetal Kp,uu of P-gp substrate drugs. UU 117-119 ATP binding cassette subfamily B member 1 Homo sapiens 123-127 17604869-8 2007 Thus, RNase L can cleave HCV RNAs efficiently and variably reduced frequencies of UA and UU dinucleotides in HCV RNA ORFs are consistent with the selective pressure of RNase L. UU 89-91 ribonuclease L Homo sapiens 6-13 34877498-3 2021 Exogenous miR-146a-5p, but not its duplex precursor, induces a strong immunostimulatory response through a newly identified UU-containing motif and TLR7 activation, and an immunotolerance by rapid IRAK-1 protein degradation via TLR7 MyD88 signaling and proteasome activation, whereas its duplex precursor acts by targeting 3" UTR of Irak-1 gene via Ago2 binding. UU 124-126 microRNA 146 Mus musculus 10-18 10421450-1 1999 Catalysed hydrolysis of butyrylthiocholine (BTCh) by the usual (UU), fluoride-resistant (FS), AK, AJ and atypical (AA) human serum butyrylcholinesterase (EC 3.1.1.8) variants was measured in phosphate buffer pH 7.4 at 25 degrees C. pS-curves for all phenotypes were S-shaped; the activities rose to a plateau with increasing substrate concentration except at 100 mM where there was a small decrease. UU 64-66 butyrylcholinesterase Homo sapiens 131-152 34211989-8 2021 HIV+ children presented significantly higher levels of seven biomarkers (CD14, IL-6 HVEM, B7.1, Siglec-10, HIF-1alpha, and CD163) than the UU group. UU 139-141 CD14 molecule Homo sapiens 73-77 34211989-8 2021 HIV+ children presented significantly higher levels of seven biomarkers (CD14, IL-6 HVEM, B7.1, Siglec-10, HIF-1alpha, and CD163) than the UU group. UU 139-141 interleukin 6 Homo sapiens 79-83 34211989-8 2021 HIV+ children presented significantly higher levels of seven biomarkers (CD14, IL-6 HVEM, B7.1, Siglec-10, HIF-1alpha, and CD163) than the UU group. UU 139-141 TNF receptor superfamily member 14 Homo sapiens 84-88 34211989-8 2021 HIV+ children presented significantly higher levels of seven biomarkers (CD14, IL-6 HVEM, B7.1, Siglec-10, HIF-1alpha, and CD163) than the UU group. UU 139-141 CD80 molecule Homo sapiens 90-94 34211989-8 2021 HIV+ children presented significantly higher levels of seven biomarkers (CD14, IL-6 HVEM, B7.1, Siglec-10, HIF-1alpha, and CD163) than the UU group. UU 139-141 sialic acid binding Ig like lectin 10 Homo sapiens 96-105 34211989-8 2021 HIV+ children presented significantly higher levels of seven biomarkers (CD14, IL-6 HVEM, B7.1, Siglec-10, HIF-1alpha, and CD163) than the UU group. UU 139-141 hypoxia inducible factor 1 subunit alpha Homo sapiens 107-117 34211989-8 2021 HIV+ children presented significantly higher levels of seven biomarkers (CD14, IL-6 HVEM, B7.1, Siglec-10, HIF-1alpha, and CD163) than the UU group. UU 139-141 CD163 molecule Homo sapiens 123-128 35314999-11 2022 CONCLUSIONS: A knockdown screening study in combination with Kp,uu,brain values showed that aripiprazole was a potential substrate of OCTN2. UU 64-66 solute carrier family 22 member 5 L homeolog Xenopus laevis 134-139