PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30706710-5	2019	The inhibition of XIAP with the restoration of PPARgamma signaling using a SMAC-mimetic (Compound A (CmpdA)) and rosiglitazone (RGZ)/retinoic acid (RA), respectively, reduced cell proliferation and induced apoptosis in the KGN cells.	CMPDA	101-106	X-linked inhibitor of apoptosis	Homo sapiens	18-22
26693062-8	2015	Additionally, the novel IKKbeta inhibitor CmpdA has been shown to consistently block the phosphorylation of NF-kappaB at serine 536 while also dramatically improving the efficacy of cisplatin in inhibition of cell proliferation and induction of apoptosis in the cisplatin resistant cancer cells.	CMPDA	42-47	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	24-31
26693062-8	2015	Additionally, the novel IKKbeta inhibitor CmpdA has been shown to consistently block the phosphorylation of NF-kappaB at serine 536 while also dramatically improving the efficacy of cisplatin in inhibition of cell proliferation and induction of apoptosis in the cisplatin resistant cancer cells.	CMPDA	42-47	nuclear factor kappa B subunit 1	Homo sapiens	108-117
24955217-5	2014	Administration of the highly specific IKKbeta inhibitor Compound A (CmpdA) led to NF-kappaB inhibition in different KRAS mutant lung cells and siRNA-mediated knockdown of IKKalpha or IKKbeta reduced activity of the NF-kappaB canonical pathway.	CMPDA	68-73	inhibitor of kappaB kinase beta	Mus musculus	38-45
24955217-5	2014	Administration of the highly specific IKKbeta inhibitor Compound A (CmpdA) led to NF-kappaB inhibition in different KRAS mutant lung cells and siRNA-mediated knockdown of IKKalpha or IKKbeta reduced activity of the NF-kappaB canonical pathway.	CMPDA	68-73	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	116-120
24955217-5	2014	Administration of the highly specific IKKbeta inhibitor Compound A (CmpdA) led to NF-kappaB inhibition in different KRAS mutant lung cells and siRNA-mediated knockdown of IKKalpha or IKKbeta reduced activity of the NF-kappaB canonical pathway.	CMPDA	68-73	conserved helix-loop-helix ubiquitous kinase	Mus musculus	171-179
24955217-5	2014	Administration of the highly specific IKKbeta inhibitor Compound A (CmpdA) led to NF-kappaB inhibition in different KRAS mutant lung cells and siRNA-mediated knockdown of IKKalpha or IKKbeta reduced activity of the NF-kappaB canonical pathway.	CMPDA	68-73	inhibitor of kappaB kinase beta	Mus musculus	183-190
24955217-8	2014	CmpdA treatment was well tolerated and mice treated with this IKKbeta inhibitor presented smaller and lower grade tumors than mice treated with placebo.	CMPDA	0-5	inhibitor of kappaB kinase beta	Mus musculus	62-69
35205437-6	2022	We show that the GRN responded differently to the addition of noise in the prediction by the RNN and we related the noise response to the analysis of the attention mechanism.	CMPDA	93-96	granulin precursor	Homo sapiens	17-20
32435511-12	2020	Furthermore, we found that simultaneous inhibition of SRC and IKKbeta through a Dasatinib and CmpdA combination synergistically inhibited NF-kappaB activation and ETS-1expression, suppressed cell proliferation, and induced apoptosis.	CMPDA	94-99	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	54-57
32435511-12	2020	Furthermore, we found that simultaneous inhibition of SRC and IKKbeta through a Dasatinib and CmpdA combination synergistically inhibited NF-kappaB activation and ETS-1expression, suppressed cell proliferation, and induced apoptosis.	CMPDA	94-99	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	62-69
32435511-12	2020	Furthermore, we found that simultaneous inhibition of SRC and IKKbeta through a Dasatinib and CmpdA combination synergistically inhibited NF-kappaB activation and ETS-1expression, suppressed cell proliferation, and induced apoptosis.	CMPDA	94-99	nuclear factor kappa B subunit 1	Homo sapiens	138-147
32435511-12	2020	Furthermore, we found that simultaneous inhibition of SRC and IKKbeta through a Dasatinib and CmpdA combination synergistically inhibited NF-kappaB activation and ETS-1expression, suppressed cell proliferation, and induced apoptosis.	CMPDA	94-99	ETS proto-oncogene 1, transcription factor	Homo sapiens	163-168
27196761-0	2016	Targeting IkappaB Kinase beta/NF-kappaB Signaling in Human Prostate Cancer by a Novel IkappaB Kinase beta Inhibitor CmpdA.	CMPDA	116-121	nuclear factor kappa B subunit 1	Homo sapiens	30-39
30585254-6	2019	In keeping with these, IKKbeta inhibitor CmpdA synergistically enhanced the efficacy of EGFR inhibitors to further inhibit in vitro HNSCC cell growth.	CMPDA	41-46	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	23-30
30585254-6	2019	In keeping with these, IKKbeta inhibitor CmpdA synergistically enhanced the efficacy of EGFR inhibitors to further inhibit in vitro HNSCC cell growth.	CMPDA	41-46	epidermal growth factor receptor	Homo sapiens	88-92
27196761-0	2016	Targeting IkappaB Kinase beta/NF-kappaB Signaling in Human Prostate Cancer by a Novel IkappaB Kinase beta Inhibitor CmpdA.	CMPDA	116-121	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	10-29
26895469-7	2016	Blockage of NF-kappaB/IKK activity by the novel IKKbeta specific inhibitor, CmpdA, leads to significant inhibition of cell proliferation and induction of apoptosis.	CMPDA	76-81	nuclear factor kappa B subunit 1	Homo sapiens	12-21
27196761-0	2016	Targeting IkappaB Kinase beta/NF-kappaB Signaling in Human Prostate Cancer by a Novel IkappaB Kinase beta Inhibitor CmpdA.	CMPDA	116-121	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	86-105
27196761-6	2016	The novel IKKbeta inhibitor CmpdA inhibits constitutively activated IKKbeta/NF-kappaB signaling, leading to induction of apoptosis and inhibition of proliferation, migration, and stemness in these cells.	CMPDA	28-33	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	10-17
27196761-6	2016	The novel IKKbeta inhibitor CmpdA inhibits constitutively activated IKKbeta/NF-kappaB signaling, leading to induction of apoptosis and inhibition of proliferation, migration, and stemness in these cells.	CMPDA	28-33	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	68-75
27196761-6	2016	The novel IKKbeta inhibitor CmpdA inhibits constitutively activated IKKbeta/NF-kappaB signaling, leading to induction of apoptosis and inhibition of proliferation, migration, and stemness in these cells.	CMPDA	28-33	nuclear factor kappa B subunit 1	Homo sapiens	76-85