PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33619847-0	2021	Different responses of the blockade of the P2Y1 receptor with BPTU in human and porcine intestinal tissues and in cell cultures.	BPTU	62-66	purinergic receptor P2Y1	Homo sapiens	43-56
33679406-8	2021	Moreover, the P2Y1R selective antagonist BPTU increased the levels of mRNA and protein of profibrogenic markers, such as connective tissue growth factor (CTGF), periostin (POSTN).	BPTU	41-45	purinergic receptor P2Y, G-protein coupled 1	Mus musculus	14-19
33679406-8	2021	Moreover, the P2Y1R selective antagonist BPTU increased the levels of mRNA and protein of profibrogenic markers, such as connective tissue growth factor (CTGF), periostin (POSTN).	BPTU	41-45	cellular communication network factor 2	Mus musculus	121-152
33679406-8	2021	Moreover, the P2Y1R selective antagonist BPTU increased the levels of mRNA and protein of profibrogenic markers, such as connective tissue growth factor (CTGF), periostin (POSTN).	BPTU	41-45	cellular communication network factor 2	Mus musculus	154-158
33679406-8	2021	Moreover, the P2Y1R selective antagonist BPTU increased the levels of mRNA and protein of profibrogenic markers, such as connective tissue growth factor (CTGF), periostin (POSTN).	BPTU	41-45	periostin, osteoblast specific factor	Mus musculus	161-170
33679406-8	2021	Moreover, the P2Y1R selective antagonist BPTU increased the levels of mRNA and protein of profibrogenic markers, such as connective tissue growth factor (CTGF), periostin (POSTN).	BPTU	41-45	periostin, osteoblast specific factor	Mus musculus	172-177
33619847-2	2021	Recently, BPTU was developed as a negative allosteric modulator of the P2Y1 receptor.	BPTU	10-14	purinergic receptor P2Y1	Homo sapiens	71-84
28864555-5	2017	BPTU rightward shifted the concentration-response curves of both 2-methylthioadenosine 5"-diphosphate trisodium salt and MRS2365 (5"-diphosphates) in some signaling events, such as extracellular signal-regulated kinase 1/2 and label free, in a parallel manner without affecting the maximum agonist effect (Emax) but antagonized insurmountably (suppressed agonist Emax) in signaling events such as guanosine 5"-3-O-(thio)triphosphate binding and beta-arrestin2 recruitment.	BPTU	0-4	mitogen-activated protein kinase 3	Homo sapiens	181-222
28864555-5	2017	BPTU rightward shifted the concentration-response curves of both 2-methylthioadenosine 5"-diphosphate trisodium salt and MRS2365 (5"-diphosphates) in some signaling events, such as extracellular signal-regulated kinase 1/2 and label free, in a parallel manner without affecting the maximum agonist effect (Emax) but antagonized insurmountably (suppressed agonist Emax) in signaling events such as guanosine 5"-3-O-(thio)triphosphate binding and beta-arrestin2 recruitment.	BPTU	0-4	arrestin beta 2	Homo sapiens	445-459
27496690-0	2016	BPTU, an allosteric antagonist of P2Y1 receptor, blocks nerve mediated inhibitory neuromuscular responses in the gastrointestinal tract of rodents.	BPTU	0-4	purinergic receptor P2Y1	Rattus norvegicus	34-38
27496690-2	2016	A new P2Y1 antagonist, with a non-nucleotide structure, BPTU, has recently been described using X-ray crystallography as the first allosteric G-protein-coupled receptor antagonist located entirely outside of the helical bundle.	BPTU	56-60	purinergic receptor P2Y1	Rattus norvegicus	6-10
27496690-8	2016	BPTU also blocked the cessation of spontaneous contractility elicited by ADPbetaS and the P2Y1 agonist MRS2365.	BPTU	0-4	purinergic receptor P2Y1	Rattus norvegicus	90-94
27496690-9	2016	We conclude that BPTU is a novel antagonist with different structural and functional properties than nucleotidic antagonists that is able to block the P2Y1 receptor located at the neuromuscular junction of the GI tract.	BPTU	17-21	purinergic receptor P2Y1	Rattus norvegicus	151-155