PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 8940716-4 1996 Data that appear to support the concept that transferrin receptor-independent transporters are rate-limiting can be resolved by considering the presence of the gallate ion, [67Ga (OH)4]-. Gallic acid 160-167 transferrin Homo sapiens 45-56 10760511-5 2000 We conclude that catechins of the green tea possessing the gallate group in their chemical structure act as anticancer agents probably partly via their ability to suppress the tyrosine kinase activity of the PDGF-Rbeta. Gallic acid 59-66 platelet derived growth factor receptor beta Homo sapiens 208-218 10364071-4 1999 Gel shift assays with the NF-kappaB consensus sequence showed the decreased densities of the shifted bands in gallate-treated HUVECs. Gallic acid 110-117 nuclear factor kappa B subunit 1 Homo sapiens 26-35 10364071-5 1999 Furthermore, gallate pretreatment inhibited cytokine-induced transcription of a fusion gene, which consisted of 4 repeats of the NF-kappaB consensus sequence and the luciferase reporter gene. Gallic acid 13-20 nuclear factor kappa B subunit 1 Homo sapiens 129-138 10554249-5 1998 Molecular mechanics (MM2) and (1)H NMR studies of dimeric 3-O-gallate structures show a pi-pi stacking arrangement between the aromatic gallate and catechol rings, absent in analogous dimeric procyanidins, which reduces the total surface accessible to oxidizing agents. Gallic acid 62-69 PNMA family member 2 Homo sapiens 21-24 35276214-0 2022 CaM kinase phosphatase (CaMKP/PPM1F/POPX2) is specifically inactivated through gallate-mediated protein carbonylation. Gallic acid 79-86 protein phosphatase, Mg2+/Mn2+ dependent 1F Homo sapiens 0-22 35276214-0 2022 CaM kinase phosphatase (CaMKP/PPM1F/POPX2) is specifically inactivated through gallate-mediated protein carbonylation. Gallic acid 79-86 protein phosphatase, Mg2+/Mn2+ dependent 1F Homo sapiens 24-29 35276214-0 2022 CaM kinase phosphatase (CaMKP/PPM1F/POPX2) is specifically inactivated through gallate-mediated protein carbonylation. Gallic acid 79-86 protein phosphatase, Mg2+/Mn2+ dependent 1F Homo sapiens 30-35 35276214-0 2022 CaM kinase phosphatase (CaMKP/PPM1F/POPX2) is specifically inactivated through gallate-mediated protein carbonylation. Gallic acid 79-86 protein phosphatase, Mg2+/Mn2+ dependent 1F Homo sapiens 36-41 35276214-7 2022 The pyrogallol structure of gallate was necessary for the gallate-mediated carbonylation of CaMKP. Gallic acid 28-35 protein phosphatase, Mg2+/Mn2+ dependent 1F Homo sapiens 92-97 35276214-7 2022 The pyrogallol structure of gallate was necessary for the gallate-mediated carbonylation of CaMKP. Gallic acid 58-65 protein phosphatase, Mg2+/Mn2+ dependent 1F Homo sapiens 92-97 35276214-10 2022 The gallate-mediated carbonylation of CaMKP absolutely required divalent cations such as Mn2+, Cu2+, Co2+ and Fe2+, and was markedly enhanced by a phosphopeptide substrate. Gallic acid 4-11 protein phosphatase, Mg2+/Mn2+ dependent 1F Homo sapiens 38-43 28760744-6 2017 Exposure to trimer gallate resulted in the transcriptional down-regulation of nhr-49 (an ortholog of the human peroxisome proliferator-activated receptor-alpha), and a key regulator of fat metabolism, and 2 downstream genes: fat-5 and acs-2 A combination exposure of 2 or 3 pOPCs (dimer gallate, trimer and/or trimer gallate) suggested the absence of synergistic potential. Gallic acid 19-26 peroxisome proliferator activated receptor alpha Homo sapiens 111-159 33851721-4 2021 We report an inhibition of the ribonucleolytic activity of Ang with the gallate containing green tea polyphenols, ECG and EGCG that exhibits an increased efficacy upon forming polyphenol-capped gold nanoparticles (ECG-AuNPs and EGCG-AuNPs). Gallic acid 72-79 angiogenin Homo sapiens 59-62 32649191-3 2020 Here we report hyperbranched polyglycerol dendrimer terminated with anti-amyloidogenic small molecules such as gallate, tyrosine and trehalose and their potential in inhibiting lysozyme/huntingtin protein aggregation under intra/extracellular space. Gallic acid 111-118 lysozyme Homo sapiens 177-185 32649191-3 2020 Here we report hyperbranched polyglycerol dendrimer terminated with anti-amyloidogenic small molecules such as gallate, tyrosine and trehalose and their potential in inhibiting lysozyme/huntingtin protein aggregation under intra/extracellular space. Gallic acid 111-118 huntingtin Homo sapiens 186-196 30155742-0 2019 Probing Gallate-Mediated Selectivity and High-Affinity Binding of Epigallocatechin Gallate: a Way-Forward in the Design of Selective Inhibitors for Anti-apoptotic Bcl-2 Proteins. Gallic acid 8-15 BCL2 apoptosis regulator Homo sapiens 163-168 30155742-5 2019 Arg143 and Asp108 (Bcl-2), and Glu96 and Tyr195 (Bcl-xL) formed high-affinity hydrogen interactions with the gallate group while non-gallate groups of EGCG formed weak interactions. Gallic acid 109-116 BCL2 apoptosis regulator Homo sapiens 19-24 30155742-5 2019 Arg143 and Asp108 (Bcl-2), and Glu96 and Tyr195 (Bcl-xL) formed high-affinity hydrogen interactions with the gallate group while non-gallate groups of EGCG formed weak interactions. Gallic acid 109-116 BCL2 like 1 Homo sapiens 49-55 29468843-0 2018 GPCR6A Is a Molecular Target for the Natural Products Gallate and EGCG in Green Tea. Gallic acid 54-61 G protein-coupled receptor 101 Homo sapiens 0-5 32275992-2 2020 Our previous study and other studies suggested that the gallate moiety played an obligatory role in the inhibition process of naturally occurring polyphenols on Abeta amyloid fibrils formation. Gallic acid 56-63 amyloid beta precursor protein Homo sapiens 161-166 28760744-6 2017 Exposure to trimer gallate resulted in the transcriptional down-regulation of nhr-49 (an ortholog of the human peroxisome proliferator-activated receptor-alpha), and a key regulator of fat metabolism, and 2 downstream genes: fat-5 and acs-2 A combination exposure of 2 or 3 pOPCs (dimer gallate, trimer and/or trimer gallate) suggested the absence of synergistic potential. Gallic acid 19-26 acyl-CoA synthetase long chain family member 5 Homo sapiens 235-240 28346686-5 2017 Experiments using GAO derivatives indicated that the gallate moiety required the presence of a long carbon chain for BCRP inhibition. Gallic acid 53-60 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 117-121 23863773-5 2013 Derivatives with a hydroxyl group para on the ester-bonded gallate moiety presented a high in vitro binding to DHFR, but exhibited transport problems in cell culture due to ionization at physiologic pHs. Gallic acid 59-66 dihydrofolate reductase Homo sapiens 111-115 24898638-3 2014 To explore potential blood biomarkers for AD via metabolic profiling with high-resolution magic angle spinning nuclear magnetic resonance techniques, we identified changes in peripheral blood metabolomic profiles in response to amyloid-beta (Abeta)-induced neuroinflammation and co-treatment with gallate, a phytochemical known to have anti-neuroinflammatory properties. Gallic acid 297-304 amyloid beta (A4) precursor protein Mus musculus 242-247 24898638-7 2014 Gallate treatment suppressed Abeta-induced overproduction of the inflammatory cytokine tumor necrosis factor-alpha in the hippocampus and normalized plasma levels of the affected metabolites. Gallic acid 0-7 amyloid beta (A4) precursor protein Mus musculus 29-34 24898638-7 2014 Gallate treatment suppressed Abeta-induced overproduction of the inflammatory cytokine tumor necrosis factor-alpha in the hippocampus and normalized plasma levels of the affected metabolites. Gallic acid 0-7 tumor necrosis factor Mus musculus 87-114 14609132-7 2003 To investigate the structure-activity relationships of gallate and gallic acid for the inhibition of iNOS and COX-2 activity, we also examined (-)-epigallocatechin gallate (EGCG), gallic acid, and gallacetophenone. Gallic acid 55-62 nitric oxide synthase 2, inducible Mus musculus 101-105 20207147-2 2010 Highly regioselective bromination of differentially protected gallate was realized by virtue of the introduction of NBS. Gallic acid 62-69 nibrin Homo sapiens 116-119 16220062-8 2005 An increase in the number of gallate groups per catechin molecule was associated with increased inhibition of angiotensin II-dependent collagen gel contraction by SMC. Gallic acid 29-36 angiotensinogen Homo sapiens 110-124 15340218-9 2004 These results suggest that gallate-containing catechins, particularly EGCG, inhibits LPS-induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation. Gallic acid 27-34 interleukin 12b Mus musculus 97-105 15340218-9 2004 These results suggest that gallate-containing catechins, particularly EGCG, inhibits LPS-induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation. Gallic acid 27-34 mitogen-activated protein kinase 14 Mus musculus 153-161 15340218-9 2004 These results suggest that gallate-containing catechins, particularly EGCG, inhibits LPS-induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation. Gallic acid 27-34 mitogen-activated protein kinase 3 Mus musculus 178-181 15340218-9 2004 These results suggest that gallate-containing catechins, particularly EGCG, inhibits LPS-induced IL-12p40 production in murine macrophages by inhibiting p38 MAPK while enhancing p44/p42 ERK, leading to the inhibition of IkappaBalpha degradation and NF-kappaB activation. Gallic acid 27-34 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha Mus musculus 220-232 23104077-6 2013 These findings suggest that the hydroxyl group at the 3"" position of the gallate ring is essential and, also, to some extent, the two hydroxyl groups at positions 3" and 4", for the EGCg-induced redox-sensitive activation of eNOS leading to the subsequent NO-mediated vascular relaxation. Gallic acid 74-81 nitric oxide synthase 3 Homo sapiens 226-230 18992738-10 2008 These results showed for the first time that tea polyphenols can induce the expression of selective RGS genes and that the gallate moiety may be important in this induction. Gallic acid 123-130 paired like homeodomain 2 Homo sapiens 100-103 17056012-7 2006 Model building studies on the human HIF prolyl hydroxylase 2 showed that the two phenolate oxygen atoms of gallate form a chelate with the active site Fe(2+), while the carboxyl group of gallate forms a strong ionic/hydrogen bonding interaction with Arg383, explaining why nPG, which has an esterified carboxyl group, is unable to inhibit the hydroxylase. Gallic acid 107-114 egl-9 family hypoxia inducible factor 1 Homo sapiens 36-60 17056012-7 2006 Model building studies on the human HIF prolyl hydroxylase 2 showed that the two phenolate oxygen atoms of gallate form a chelate with the active site Fe(2+), while the carboxyl group of gallate forms a strong ionic/hydrogen bonding interaction with Arg383, explaining why nPG, which has an esterified carboxyl group, is unable to inhibit the hydroxylase. Gallic acid 187-194 egl-9 family hypoxia inducible factor 1 Homo sapiens 36-60 17056012-8 2006 Together with the observation that gallate was detected in the H9c2 cells treated with nPG, these results suggest that nPG incorporated into the cells is hydrolyzed and the released gallate inhibits the HIF prolyl hydroxylase, thereby reducing the HIF degradation rate and increasing the HIF-1alpha content. Gallic acid 182-189 hypoxia inducible factor 1 subunit alpha Rattus norvegicus 288-298 15081893-1 2004 Gallic acid (GA) and several gallate derivatives were identified as inhibitors of fucosyltransferase VII (FucT VII). Gallic acid 29-36 fucosyltransferase 7 Homo sapiens 82-104 15081893-1 2004 Gallic acid (GA) and several gallate derivatives were identified as inhibitors of fucosyltransferase VII (FucT VII). Gallic acid 29-36 fucosyltransferase 7 Homo sapiens 106-114 14609132-7 2003 To investigate the structure-activity relationships of gallate and gallic acid for the inhibition of iNOS and COX-2 activity, we also examined (-)-epigallocatechin gallate (EGCG), gallic acid, and gallacetophenone. Gallic acid 55-62 cytochrome c oxidase II, mitochondrial Mus musculus 110-115 11936850-8 2002 The results indicate that the gallate moiety in the catechin molecule may result in a beneficial effect on lipid metabolism in terms of apoB secretion. Gallic acid 30-37 apolipoprotein B Homo sapiens 136-140