PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 21296658-0 2011 Differential accumulation of HCBz and PeCBz in porcine ovarian follicles and their opposing actions on steroid secretion and CYP11, CYP17, 17beta-HSD and CYP19 protein expression. pentachlorobenzene 38-43 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 132-137 21296658-0 2011 Differential accumulation of HCBz and PeCBz in porcine ovarian follicles and their opposing actions on steroid secretion and CYP11, CYP17, 17beta-HSD and CYP19 protein expression. pentachlorobenzene 38-43 hydroxysteroid 17-beta dehydrogenase 1 Homo sapiens 139-149 21296658-0 2011 Differential accumulation of HCBz and PeCBz in porcine ovarian follicles and their opposing actions on steroid secretion and CYP11, CYP17, 17beta-HSD and CYP19 protein expression. pentachlorobenzene 38-43 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 154-159 20131084-7 2010 A low degree of nitro group removal resulting in the formation of pentachlorobenzene (PeCB) was also observed in the control culture when amended with 13 muM PCNB. pentachlorobenzene 66-84 latexin Homo sapiens 154-157 20131084-7 2010 A low degree of nitro group removal resulting in the formation of pentachlorobenzene (PeCB) was also observed in the control culture when amended with 13 muM PCNB. pentachlorobenzene 86-90 latexin Homo sapiens 154-157 15515957-4 2004 Finally, the AhR acitivity of hexachlorobenzene and pentachlorobenzene were assessed, and their toxicity equivalent factors were found to be 0.018629 and 0.000294, respectively. pentachlorobenzene 52-70 aryl hydrocarbon receptor Homo sapiens 13-16 9630449-1 1998 A distinct, nonfocal expression pattern was observed for glutathione S-transferase P1-1 (rGSTP1-1) in rats exposed to either hexachloro-(HCB) or pentachlorobenzene (PeCB). pentachlorobenzene 145-163 glutathione S-transferase pi 1 Rattus norvegicus 89-97 12700395-1 2003 A combination of experimental and simulation approaches was used to analyze clonal growth of glutathione-S-transferase pi (GST-P) enzyme-altered foci during liver carcinogenesis in an initiation-promotion regimen for 1,4-dichlorobenzene (DCB), 1,2,4,5-tetrachlorobenzene (TECB), pentachlorobenzene (PECB), and hexachlorobenzene (HCB). pentachlorobenzene 279-297 glutathione S-transferase pi 1 Rattus norvegicus 123-128 12700395-1 2003 A combination of experimental and simulation approaches was used to analyze clonal growth of glutathione-S-transferase pi (GST-P) enzyme-altered foci during liver carcinogenesis in an initiation-promotion regimen for 1,4-dichlorobenzene (DCB), 1,2,4,5-tetrachlorobenzene (TECB), pentachlorobenzene (PECB), and hexachlorobenzene (HCB). pentachlorobenzene 299-303 glutathione S-transferase pi 1 Rattus norvegicus 123-128 9630449-1 1998 A distinct, nonfocal expression pattern was observed for glutathione S-transferase P1-1 (rGSTP1-1) in rats exposed to either hexachloro-(HCB) or pentachlorobenzene (PeCB). pentachlorobenzene 165-169 glutathione S-transferase pi 1 Rattus norvegicus 89-97 9630449-3 1998 A Western blot analysis revealed a 5- and 15-fold induction of rGSTP1-1 with PeCB and HCB treatment on an equal molar basis, respectively. pentachlorobenzene 77-81 glutathione S-transferase pi 1 Rattus norvegicus 63-69 7747284-5 1995 The ratio between the activities of CYP2E1 and CYP3A4 with respect to the oxidation of chlorinated benzenes decreased from 150 (1,2-dichlorobenzene) to 1.8 (pentachlorobenzene). pentachlorobenzene 157-175 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 36-42 7747284-5 1995 The ratio between the activities of CYP2E1 and CYP3A4 with respect to the oxidation of chlorinated benzenes decreased from 150 (1,2-dichlorobenzene) to 1.8 (pentachlorobenzene). pentachlorobenzene 157-175 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 47-53 7747284-3 1995 Furthermore, CYP1A1 and CYP1A2 showed relatively high enzymatic activities toward the lower chlorinated benzenes (1,2-dichlorobenzene, 1,4-dichlorobenzene, 1,2,4-trichlorobenzene) and CYP3A4 toward the higher chlorinated benzenes (1,2,3,5-tetrachlorobenzene, pentachlorobenzene). pentachlorobenzene 259-277 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 13-19 12209162-0 1991 NTP technical report on the toxicity studies of Pentachlorobenzene in F344/N Rats and B6C3F1 Mice (Feed Studies) (CAS No. pentachlorobenzene 48-66 breast cancer anti-estrogen resistance 1 Mus musculus 114-117 7747284-3 1995 Furthermore, CYP1A1 and CYP1A2 showed relatively high enzymatic activities toward the lower chlorinated benzenes (1,2-dichlorobenzene, 1,4-dichlorobenzene, 1,2,4-trichlorobenzene) and CYP3A4 toward the higher chlorinated benzenes (1,2,3,5-tetrachlorobenzene, pentachlorobenzene). pentachlorobenzene 259-277 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 24-30 8156603-5 1994 The biotransformation of HCB and PCBz was modulated by selective inhibition of cytochrome P450IIIA in rats which received combined treatment of HCB or PCBz with triacetyloleandomycin (TAO). pentachlorobenzene 33-37 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 90-98 8156603-5 1994 The biotransformation of HCB and PCBz was modulated by selective inhibition of cytochrome P450IIIA in rats which received combined treatment of HCB or PCBz with triacetyloleandomycin (TAO). pentachlorobenzene 151-155 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 Rattus norvegicus 90-98 23852585-5 2014 Among the phthalocyanine-type pigments, highly chlorinated PCBs, mainly composed of PCB-209, PeCBz, and HxCBz were detected. pentachlorobenzene 93-98 pyruvate carboxylase Homo sapiens 59-62 3768314-6 1986 Pentachlorobenzene (PCB) appears to be the initial and major isolatable CYT P-450 mediated dechlorination product of HCB with NADPH-fortified rat liver microsomes. pentachlorobenzene 0-18 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 72-81 3768314-6 1986 Pentachlorobenzene (PCB) appears to be the initial and major isolatable CYT P-450 mediated dechlorination product of HCB with NADPH-fortified rat liver microsomes. pentachlorobenzene 20-23 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 72-81 3768314-10 1986 The data indicate that CYT P-450 in hepatic microsomes supports the reductive dechlorination of HCB to PCB. pentachlorobenzene 103-106 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 23-32 3596752-0 1986 Hexachlorobenzene and substituted pentachlorobenzenes (X-C6Cl5) as inducers of hepatic cytochrome P-450-dependent mono-oxygenases. pentachlorobenzene 34-53 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 87-103 3596752-2 1986 Levels of individual cytochrome P-450 isozymes and various mono-oxygenase activities in liver microsomes from rats treated with substituted pentachlorobenzene (X-C6Cl5) and 4"-substituted-2,3,4,5-tetrachlorobiphenyl (X-C12 H5Cl4) analogues demonstrated the remarkable effects of substituent structure on induction activities. pentachlorobenzene 140-158 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 21-37 2675838-4 1989 During this cytochrome P450-dependent conversion of pentachlorobenzene, 5-15% of the total amount of metabolites becomes covalently bound to microsomal protein. pentachlorobenzene 52-70 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 12-27 25892359-6 2015 Liver CYP1A1 expression correlated positively and significantly with blubber concentrations of all POP categories (n = 39, p < 0.050) except octachlorostyrene and pentachlorobenzene (p > 0.100). pentachlorobenzene 166-184 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 6-12