PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33015833-5	2020	Doa10 cooperates with the dedicated priming E2, Ubc6, while both E3s use Ubc7 for elongation.	CHEMBL4061503	65-68	E2 ubiquitin-conjugating protein UBC7	Saccharomyces cerevisiae S288C	73-77
33882749-7	2021	To explore the hypothesis that enzymatic inhibition of E3s may result in modulation of disease-related signaling pathways, we established a high-throughput screen of >70,000 chemical entities for inhibition of CBLB activity.	CHEMBL4061503	55-58	Cbl proto-oncogene B	Homo sapiens	210-214
34027397-3	2021	Several studies have demonstrated the essential role of a group of ER (endoplasmic reticulum)-localized E3s in the positive or negative regulation of cell homeostasis.	CHEMBL4061503	104-107	epiregulin	Homo sapiens	67-69
33199914-4	2021	However, limited insights into ternary complex structures exist, including a near absence of studies on one of the most widely co-opted E3s, cellular inhibitor of apoptosis 1 (cIAP1).	CHEMBL4061503	136-139	baculoviral IAP repeat containing 2	Homo sapiens	176-181
32393902-5	2020	While numerous studies have unveiled how RING E3s stimulate individual E2s for Ub transfer, here we change perspective to describe a case where the chain-elongating E2 UBE2S feeds back and directly stimulates the E3 APC/C to promote substrate priming and subsequent multiubiquitination by UBE2C.	CHEMBL4061503	46-49	ubiquitin conjugating enzyme E2 S	Homo sapiens	168-173
32986984-6	2020	Here, we summarize regulatory principles of CRL3 assembly, substrate recruitment, and ubiquitylation that allow this class of E3s to fulfill their manifold functions in development.	CHEMBL4061503	126-129	interleukin 31 receptor A	Homo sapiens	44-48
32393902-5	2020	While numerous studies have unveiled how RING E3s stimulate individual E2s for Ub transfer, here we change perspective to describe a case where the chain-elongating E2 UBE2S feeds back and directly stimulates the E3 APC/C to promote substrate priming and subsequent multiubiquitination by UBE2C.	CHEMBL4061503	46-49	ubiquitin conjugating enzyme E2 C	Homo sapiens	289-294
28945155-4	2018	For OAT7, high uptake ratios (versus mock transfected HEK293 cells) of 29.6 and 15.3 were obtained with E3S and DHEAS.	CHEMBL4061503	104-107	solute carrier family 22 member 9	Homo sapiens	4-8
28945155-6	2018	OAT2 (transcript variant 1, OAT2-tv1) presented high uptake ratios of 30, 13, ~35, ~25, 8.5 and 9 with cGMP, PAH, penciclovir, ganciclovir, creatinine and E3S, respectively.	CHEMBL4061503	155-158	solute carrier family 22 member 7	Homo sapiens	0-4
28945155-6	2018	OAT2 (transcript variant 1, OAT2-tv1) presented high uptake ratios of 30, 13, ~35, ~25, 8.5 and 9 with cGMP, PAH, penciclovir, ganciclovir, creatinine and E3S, respectively.	CHEMBL4061503	155-158	solute carrier family 22 member 7	Homo sapiens	28-32
31160341-6	2019	We noted that coordination of the acceptor lysine leads to remodeling of amino acid side-chain interactions between the UBE2E1 active site and the E2-E3 direct interface, including the so-called "linchpin" residue conserved in RING E3s and required for ubiquitination.	CHEMBL4061503	232-235	ubiquitin conjugating enzyme E2 E1	Homo sapiens	120-126
21084765-2	2010	In the present study, we investigated possible interaction of Oatp with the PDZ protein PDZK1 in mouse small intestine, using [3H]estrone-3-sulfate (E3S) as a typical substrate.	CHEMBL4061503	149-152	PDZ domain containing 1	Mus musculus	88-93
28945155-12	2018	However, measurement of OAT7 activity therein will prove more challenging, as high uptake rates are evident with E3S and DHEAS only and both sulfoconjugates are known to be substrates of organic anion transporting polypeptides.	CHEMBL4061503	113-116	solute carrier family 22 member 9	Homo sapiens	24-28