PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25330680-2	2014	METHODS: Pancreatic acinar cells from adult Kunming mice were isolated acutely with collagenase, and then loaded with fluo-4-AM, a Ca2+ indicator.	fluo-4 am	118-127	carbonic anhydrase 2	Mus musculus	131-134
19124536-8	2009	Exposure of organotypic cultures to either BDNF or aMCM increased overall excitability of the dorsal horn, as seen by increased cytoplasmic Ca(2+) responses to 35 mm K(+) as monitored by confocal Fluo-4AM imaging.	fluo-4 am	196-204	brain-derived neurotrophic factor	Rattus norvegicus	43-47
25033553-1	2014	Using the fluorescent probe Fluo-4 AM the authors have identified Na(+)-independent Ca2+H(+)-exchange in isolated mitochondria of rat myometrium and studied its individual properties.	fluo-4 am	28-37	carbonic anhydrase 2	Rattus norvegicus	84-87
23406612-5	2013	Treatment with 4 microM LL-37 caused an acute and sustained rise in intracellular Ca(2+) concentration assessed by laser-scanning confocal microscopy of Fluo-4-AM-loaded MG63 cells.	fluo-4 am	153-162	cathelicidin antimicrobial peptide	Homo sapiens	24-29
24218268-5	2014	Here, we describe three assays to assess C5a-mediated effector functions: (1) increase in (Ca(2+))i in bone marrow-derived neutrophils using the intracellular fluorescent Ca(2+)-sensitive indicator Fluo-4 AM and flow cytometry-based methods; (2) in vitro migration of murine, bone marrow-derived neutrophils using a modified Boyden chamber; and (3) in vivo migration of neutrophils from the circulation into the peritoneal cavity.	fluo-4 am	198-207	hemolytic complement	Mus musculus	41-44
18055806-5	2007	EphB2-Fc or control Fc protein was applied in a bath or locally to axons preloaded with the calcium indicator Fluo-4-AM, and changes in intra-axonal calcium were determined.	fluo-4 am	110-119	Eph receptor B2	Mus musculus	0-5
18264983-7	2008	Functional tests on single nuclei, by means of confocal microscopy and the calcium-sensitive probe fluo-4AM, showed that BK induces concentration-dependent transitory mobilization of nucleoplasmic calcium; these responses were blocked by B2R antagonist HOE 140, not by the B1R antagonist R954 and, were also found in wild-type C57/Bl6 mice, but not in B2R-KO mice.	fluo-4 am	99-107	bradykinin receptor, beta 2	Mus musculus	238-241
17531386-4	2007	3,4-DHBA (1 and 10 microM) inhibited 10 microM Abeta (25-35)-induced elevation of cytosolic Ca(2+) concentration ([Ca(2+)](c)), which was measured by a fluorescent dye, Fluo-4 AM.	fluo-4 am	169-178	amyloid beta precursor protein	Rattus norvegicus	47-52
30442153-5	2018	Fluo-4AM was used to measure cytosolic Ca2+ level in beta-amyloid (Abeta) induced reactive astrocytes in vitro.	fluo-4 am	0-8	amyloid beta (A4) precursor protein	Mus musculus	67-72
16978655-4	2006	Catechin and epicatechin inhibited 10 microM Abeta (25-35)-induced elevation of cytosolic calcium concentration ([Ca2+]c), which was measured by a fluorescent dye, Fluo-4 AM.	fluo-4 am	164-173	amyloid beta precursor protein	Rattus norvegicus	45-50
16497458-5	2006	SCR (50 microg/ml) inhibited 10 microM Abeta (25-35)-induced elevation of cytosolic calcium concentration ([Ca2+]c), which was measured by a fluorescent dye, Fluo-4 AM.	fluo-4 am	158-167	amyloid beta precursor protein	Rattus norvegicus	39-44
14657189-3	2004	Confocal laser imaging of 300-microm-thick slices of neonatal mouse olfactory epithelium loaded with the Ca(2+)-indicator dye fluo-4 AM revealed that dopaminergic suppression of odor responses could be blocked by the D2 dopamine receptor antagonist sulpiride (<500 microM).	fluo-4 am	126-135	dopamine receptor D2	Mus musculus	217-237
12661552-1	2003	Isolated chondrocytes stained with fluo 4-AM and visualized using standard confocal microscopy techniques exhibited Ca2- transients and oscillations.	fluo-4 am	35-44	carbonic anhydrase 2	Homo sapiens	116-119
10934253-2	2000	To test this hypothesis, we analyzed the dynamics of presynaptic Ca(2+) ion influx with the Ca(2+) indicator fluo-4 AM at csp mutant neuromuscular junctions of Drosophila.	fluo-4 am	109-118	Cysteine string protein	Drosophila melanogaster	122-125
33879157-8	2021	The concentration of intracellular free calcium ion (Ca2+) was measured using Fluo-4 AM.	fluo-4 am	78-87	carbonic anhydrase 2	Rattus norvegicus	53-56
29621761-11	2018	Fluo-4AM staining was used to assess intracellular Ca2+ to reflect TRPV5 function of mediation Ca2+ influx.	fluo-4 am	0-8	transient receptor potential cation channel, subfamily V, member 5	Rattus norvegicus	67-72
29100878-4	2018	Using Fluo-4 AM, measurements of intracellular calcium ions demonstrated that 24h-exposure to Cd2+ induced intensive increase of Fluo-4 fluorescence in neurons accompanied by mitochondria swelling.	fluo-4 am	6-15	CD2 molecule	Homo sapiens	94-97
28097631-2	2017	Using a parallel plate flow chamber technique and intracellular calcium ion detector (Fluo-4 AM), the intracellular calcium flux of firmly adhered neutrophils on immobilized P-selectin in the absence of chemokines at various wall shear stresses was investigated here in real time by fluorescence microscopy.	fluo-4 am	86-95	selectin P	Homo sapiens	174-184
25954808-5	2015	Functionally, we found an iCa2+ rise after NMDA treatment in Fluo-4-AM labeled rCCA, an effect blocked by the NMDAR competitive inhibitors D(-)-2-amino-5-phosphonopentanoic acid (APV) and Kynurenic acid (KYNA) and dependent upon GluN1 expression as evidenced by siRNA knock down.	fluo-4 am	61-70	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	229-234
26047500-6	2015	Intracellular calcium release was evaluated by Fluo 4-AM staining and showed that inhibition of the B2R prevented calcium release following STS treatment.	fluo-4 am	47-56	bradykinin receptor B2	Rattus norvegicus	100-103