PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33531488-3	2021	CMD1 exhibits comparable binding affinities for DNAs of different lengths, structures, and 5mC levels, and displays a moderate substrate preference for 5mCpG-containing DNA.	5-Methylcytidine 5'-monophosphate	91-94	SRY-box transcription factor 9	Homo sapiens	0-4
33359809-8	2021	Our crystal structure of UHRF1 SRA bound to fully-mCpHpG DNA reveals dual flip-out mechanism of 5mC recognition.	5-Methylcytidine 5'-monophosphate	96-99	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	25-30
33359809-8	2021	Our crystal structure of UHRF1 SRA bound to fully-mCpHpG DNA reveals dual flip-out mechanism of 5mC recognition.	5-Methylcytidine 5'-monophosphate	96-99	steroid receptor RNA activator 1	Homo sapiens	31-34
32616016-1	2020	BACKGROUND: Ten-eleven translocation (Tet) methyl-cytosine dioxygenases (including Tet1/2/3)-mediated 5mC oxidation and DNA demethylation play important roles in embryonic development and adult tissue homeostasis.	5-Methylcytidine 5'-monophosphate	102-105	tet methylcytosine dioxygenase 1	Mus musculus	83-91
32759296-6	2020	We hypothesized that ten-eleven translocation (TET) enzymes, which oxidize 5mC on DNA could mediate KIR promoter demethylation.	5-Methylcytidine 5'-monophosphate	75-78	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	Homo sapiens	100-103
31807777-1	2020	Tet3 regulates the dynamic balance between 5-methylcyotsine (5mC) and 5-hydroxymethylcytosine (5hmC) in DNA during brain development and homeostasis.	5-Methylcytidine 5'-monophosphate	61-64	tet methylcytosine dioxygenase 3	Mus musculus	0-4
31805318-0	2020	5mC profiling characterized TET2 as an anti-adipogenic demethylase.	5-Methylcytidine 5'-monophosphate	0-3	tet methylcytosine dioxygenase 2	Mus musculus	28-32
32221779-7	2020	Furthermore, 5mC significantly increased with age at two regulatory regions of Cyp2e1 in tandem with decreases in its gene and protein expressions.	5-Methylcytidine 5'-monophosphate	13-16	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	79-85
31534549-8	2019	In GC cells, PGE2 induced DNMT3B expression and activity, leading to increased methylated cytosine (5mC) and promoter methylation of tumor suppressive genes (MGMT and CNR1).	5-Methylcytidine 5'-monophosphate	100-103	DNA methyltransferase 3B	Mus musculus	26-32
30933372-5	2019	Mechanistically, HNF4A-associated hydroxymethylation (5hmC) requires its interaction with ten-eleven translocation methylcytosine dioxygenase 3 (TET3), a protein responsible for oxidation from 5mC to 5hmC.	5-Methylcytidine 5'-monophosphate	193-196	hepatic nuclear factor 4, alpha	Mus musculus	17-22
30933372-5	2019	Mechanistically, HNF4A-associated hydroxymethylation (5hmC) requires its interaction with ten-eleven translocation methylcytosine dioxygenase 3 (TET3), a protein responsible for oxidation from 5mC to 5hmC.	5-Methylcytidine 5'-monophosphate	193-196	tet methylcytosine dioxygenase 3	Mus musculus	101-143
30933372-5	2019	Mechanistically, HNF4A-associated hydroxymethylation (5hmC) requires its interaction with ten-eleven translocation methylcytosine dioxygenase 3 (TET3), a protein responsible for oxidation from 5mC to 5hmC.	5-Methylcytidine 5'-monophosphate	193-196	tet methylcytosine dioxygenase 3	Mus musculus	145-149
31733060-7	2020	Like 5mC, methylation at the sixth position of adenine (6mA) in the AAC element also inhibits the interaction between WER and its target DNA.	5-Methylcytidine 5'-monophosphate	5-8	myb domain protein 66	Arabidopsis thaliana	118-121
31733060-8	2020	Our study not only unravels the molecular basis of how WER recognizes its target DNA, but also suggests that 5mC and 6mA modifications may block the interaction between R2R3-MYB transcription factors and their target genes.	5-Methylcytidine 5'-monophosphate	109-112	myb domain protein 66	Arabidopsis thaliana	55-58
31117883-9	2019	In addition, the 5mC level of the TRAF6 promoter was significantly decreased following 5-Aza-CdR pretreatment in the LPS-stimulated hDPCs.	5-Methylcytidine 5'-monophosphate	17-20	TNF receptor associated factor 6	Homo sapiens	34-39
31534549-9	2019	Consistently, Cox-2 (rate-limiting enzyme for PGE2 biosynthesis) transgenic expression in mice significantly induced Dnmt3b expression, increased 5mC content, and promoted Mgmt promoter methylation.	5-Methylcytidine 5'-monophosphate	146-149	cytochrome c oxidase II, mitochondrial	Mus musculus	14-19
30915120-7	2019	The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line.	5-Methylcytidine 5'-monophosphate	117-120	CD274 molecule	Homo sapiens	28-33
31361780-6	2019	We show that TET1, which converts 5-methylcytosine residues (5mC) to 5-hydroxymethylated cytosines (5hmC), controls transcription of Fgf8 during GnRH neuron ontogenesis.	5-Methylcytidine 5'-monophosphate	61-64	tet methylcytosine dioxygenase 1	Mus musculus	13-17
31361780-6	2019	We show that TET1, which converts 5-methylcytosine residues (5mC) to 5-hydroxymethylated cytosines (5hmC), controls transcription of Fgf8 during GnRH neuron ontogenesis.	5-Methylcytidine 5'-monophosphate	61-64	fibroblast growth factor 8	Mus musculus	133-137
30742007-5	2019	Accordingly, DNA CpG methylation (5mC) and hydroxymethylation (5hmC) at the CRH intron, which we found to serve as a repressor element, displayed low 5mc% alongside high 5hmc% in resilient chicks, and high 5mc% with low 5hmc% in vulnerable ones.	5-Methylcytidine 5'-monophosphate	150-153	corticotropin releasing hormone	Homo sapiens	76-79
30742007-5	2019	Accordingly, DNA CpG methylation (5mC) and hydroxymethylation (5hmC) at the CRH intron, which we found to serve as a repressor element, displayed low 5mc% alongside high 5hmc% in resilient chicks, and high 5mc% with low 5hmc% in vulnerable ones.	5-Methylcytidine 5'-monophosphate	206-209	corticotropin releasing hormone	Homo sapiens	76-79
30150382-5	2018	We reveal that SUVH6 has a distinct 5-methyl-dC (5mC) base-flipping mechanism involving a thumb loop element.	5-Methylcytidine 5'-monophosphate	49-52	SU(VAR)3-9 homolog 6	Arabidopsis thaliana	15-20
30102379-2	2018	Here, we identify the 5mC-binding protein MeCP2 as a direct and strong interactor of DNA methyltransferase 3 (DNMT3) proteins.	5-Methylcytidine 5'-monophosphate	22-25	methyl-CpG binding protein 2	Homo sapiens	42-47
30447571-10	2019	In the group where the mother and child were both diagnosed with depression, we found a statistically significant decrease of the 5mC level at the SLC6A4 promoter region.	5-Methylcytidine 5'-monophosphate	130-133	solute carrier family 6 member 4	Homo sapiens	147-153
30396016-6	2019	Moreover, the use of methylation-specific 5mC antibody conjugated GOx makes this assay relatively highly selective for DNA methylation analysis.	5-Methylcytidine 5'-monophosphate	42-45	hydroxyacid oxidase 1	Homo sapiens	66-69
30532647-4	2018	Since 5mC levels influence gene expression and can be long-lasting, altered 5mC status at specific sites or throughout the genome is hypothesized to influence mental and physical outcomes after ACE(s).	5-Methylcytidine 5'-monophosphate	6-9	angiotensin I converting enzyme	Homo sapiens	194-197
30532647-4	2018	Since 5mC levels influence gene expression and can be long-lasting, altered 5mC status at specific sites or throughout the genome is hypothesized to influence mental and physical outcomes after ACE(s).	5-Methylcytidine 5'-monophosphate	76-79	angiotensin I converting enzyme	Homo sapiens	194-197
30300721-4	2018	In this study, we have used LC-MS/MS to track down the fate of the methyl group removed from 5mC on DNA by mouse DNMT3B in vitro and found that it becomes covalently linked to the DNA methylation catalytic cysteine of the enzyme.	5-Methylcytidine 5'-monophosphate	93-96	DNA methyltransferase 3B	Mus musculus	113-119
29466785-6	2018	RESULTS: MM-102 (75 muM) treatment reduced global H3K4, H3K9 methylation and 5mC levels especially at the zygotic gene activation (ZGA) and blastocyst stages.	5-Methylcytidine 5'-monophosphate	77-80	latexin	Homo sapiens	20-23
29912476-7	2018	Besides a precise estimation and display of strand specific 5mC and 5hmC levels at base resolution we apply the data to predict region specific activities of Dnmt and Tet enzymes.	5-Methylcytidine 5'-monophosphate	60-63	DNA methyltransferase (cytosine-5) 1	Mus musculus	158-162
29912476-9	2018	Based on our data we predict region specific Tet and Dnmt enzyme efficiencies shaping the distinct locus levels and patterns of 5hmC and 5mC.	5-Methylcytidine 5'-monophosphate	137-140	DNA methyltransferase (cytosine-5) 1	Mus musculus	53-57
29277934-14	2018	Genomic 5hmC levels significantly decreased, and total 5mC levels increased in TET1-deficient hDPCs.	5-Methylcytidine 5'-monophosphate	55-58	tet methylcytosine dioxygenase 1	Homo sapiens	79-83
29482634-5	2018	For KAP1-bound TEs, 5mC hydroxylation correlated with transcriptional reactivation.	5-Methylcytidine 5'-monophosphate	20-23	tripartite motif-containing 28	Mus musculus	4-8
29892907-2	2018	In order to understand how a single 5mC regulates protein-DNA interactions, we have compared the structures and dynamics of CEBP/betaprotein-DNA complexes before and after methylation, and the results indicate that even a single 5mC can regulate protein-DNA recognition by steric-hindrance effect of methyl group and changing the hydrogen bond interactions.	5-Methylcytidine 5'-monophosphate	36-39	CCAAT enhancer binding protein alpha	Homo sapiens	124-128
29892907-2	2018	In order to understand how a single 5mC regulates protein-DNA interactions, we have compared the structures and dynamics of CEBP/betaprotein-DNA complexes before and after methylation, and the results indicate that even a single 5mC can regulate protein-DNA recognition by steric-hindrance effect of methyl group and changing the hydrogen bond interactions.	5-Methylcytidine 5'-monophosphate	229-232	CCAAT enhancer binding protein alpha	Homo sapiens	124-128
28115522-1	2017	UHRF2 has been implicated as a novel regulator for both DNA methylation (5mC) and hydroxymethylation (5hmC), but its physiological function and role in DNA methylation/hydroxymethylation are unknown.	5-Methylcytidine 5'-monophosphate	73-76	ubiquitin-like, containing PHD and RING finger domains 2	Mus musculus	0-5
28520399-8	2017	By overexpressing TET1 catalytic domain (responsible for oxidation 5mC to produce 5hmC) in human MCF-7 cells, we observed a significant increase in accessible 5hmC along with an increase in total 5hmC sites.	5-Methylcytidine 5'-monophosphate	67-70	tet methylcytosine dioxygenase 1	Homo sapiens	18-22
28063323-1	2017	To improve our understanding of the abnormalities and non-Mendelian inheritance characteristics of schizophrenia, this study examined DNA methylation (5mC) and hydroxymethylation (5hmC) in the schizophrenia-associated GABRB2 gene encoding the type A gamma-aminobutyric acid receptor beta2 subunit.	5-Methylcytidine 5'-monophosphate	151-154	gamma-aminobutyric acid type A receptor subunit beta2	Homo sapiens	218-224
28063323-2	2017	DNAs from the peripheral white blood cells of 279 schizophrenic patients and 256 controls from the Chinese Han population were examined to reveal that the GABRB2 promoter P1-5mC level which was correlated with olanzapine administration, P2-5mC/5hmC level, and Alu-5mC level which was correlated with administration of ziprasidone or oxcarbazepine, were increased in schizophrenic patients.	5-Methylcytidine 5'-monophosphate	174-177	gamma-aminobutyric acid type A receptor subunit beta2	Homo sapiens	155-161
28063323-6	2017	An elevated GABRB2 mRNA transcriptional level in human neuroblastoma IMR32 cells were accompanied by the decreased promoter 5hmC/5mC levels induced by 5-azacytidine or by increased histone H4 acetylation levels of the Alu-Yi6 region induced by valproic acid.	5-Methylcytidine 5'-monophosphate	129-132	gamma-aminobutyric acid type A receptor subunit beta2	Homo sapiens	12-18
28940661-3	2017	Recent results suggest that absence of maintenance at DNA replication is a major factor, and that there is an unexpected role for TET3-mediated oxidation of 5mC to 5hmC in guarding against de novo methylation.	5-Methylcytidine 5'-monophosphate	157-160	tet methylcytosine dioxygenase 3	Homo sapiens	130-134
28757075-2	2017	The isotype TET-3 is responsible for the conversion of 5mc (5-methylcytosine) to 5hmc (5-hydroxymethylcytosine) at the pronuclear stages of mouse embryo.	5-Methylcytidine 5'-monophosphate	55-58	tet methylcytosine dioxygenase 3	Mus musculus	12-17
28757075-11	2017	High TET-3 concentrations observed mainly in male pronucleus using immunofluorescent staining, implying that TET-3 might be the main enzyme which catalyzes the conversion of 5mc to 5hmc.	5-Methylcytidine 5'-monophosphate	174-177	tet methylcytosine dioxygenase 3	Mus musculus	5-10
28757075-11	2017	High TET-3 concentrations observed mainly in male pronucleus using immunofluorescent staining, implying that TET-3 might be the main enzyme which catalyzes the conversion of 5mc to 5hmc.	5-Methylcytidine 5'-monophosphate	174-177	tet methylcytosine dioxygenase 3	Mus musculus	109-114
28248100-5	2017	Pumping at 530 nm leads to ultrafast nonradiative relaxation from the singlet metal-to-ligand charge transfer (1MLCT) excited state into a quintet metal centered state (5MC) as has been observed for prototypical low-spin Fe(II) polypyridine complexes such as [Fe(tpy)2]2+.	5-Methylcytidine 5'-monophosphate	169-172	spindlin 1	Homo sapiens	216-220
26366235-11	2015	In addition, we show here for the first time applying knockdown experiments that 5-AZA is able to trigger an active TET2-dependent demethylation process with concomitant significant changes in 5hmC/5mC in HCC cell lines and hHeps.	5-Methylcytidine 5'-monophosphate	198-201	tet methylcytosine dioxygenase 2	Homo sapiens	116-120
28010926-6	2017	Multiple regression analysis between DNA methylation, DNA damage, and PM10 exposure showed that PM10 was significantly associated with oxidative DNA damage; a 1% increase in 5mC at all CpG sites in PARP1 promoter was associated with a 35% increase in 8-OHdG, while a 1% increase at 1, 2, and 3 CpG sites resulted in 38, 9, and 56% increments, respectively.	5-Methylcytidine 5'-monophosphate	174-177	poly(ADP-ribose) polymerase 1	Homo sapiens	198-203
27840027-5	2016	Thus, SALL4A facilitates further oxidation of 5hmC at its binding sites, which requires its 5hmC-binding activity and TET2, supporting a collaborative action between SALL4A and TET proteins in regulating stepwise oxidation of 5mC at enhancers.	5-Methylcytidine 5'-monophosphate	226-229	tet methylcytosine dioxygenase 2	Mus musculus	118-122
26659261-3	2016	The enzymes methylating CpG dinucleotides and those involved in the active demethylation of 5-metylcytosine (5mC) are outlined together with the members of the methyl binding protein (MBP) family that bind to and "interpret" the 5mC mark.	5-Methylcytidine 5'-monophosphate	109-112	myelin basic protein	Homo sapiens	160-182
26659261-3	2016	The enzymes methylating CpG dinucleotides and those involved in the active demethylation of 5-metylcytosine (5mC) are outlined together with the members of the methyl binding protein (MBP) family that bind to and "interpret" the 5mC mark.	5-Methylcytidine 5'-monophosphate	109-112	myelin basic protein	Homo sapiens	184-187
26659261-3	2016	The enzymes methylating CpG dinucleotides and those involved in the active demethylation of 5-metylcytosine (5mC) are outlined together with the members of the methyl binding protein (MBP) family that bind to and "interpret" the 5mC mark.	5-Methylcytidine 5'-monophosphate	229-232	myelin basic protein	Homo sapiens	160-182
26659261-3	2016	The enzymes methylating CpG dinucleotides and those involved in the active demethylation of 5-metylcytosine (5mC) are outlined together with the members of the methyl binding protein (MBP) family that bind to and "interpret" the 5mC mark.	5-Methylcytidine 5'-monophosphate	229-232	myelin basic protein	Homo sapiens	184-187
27653243-6	2016	Stabilizing hydrogen bonds (H-bonds) formed by the hydroxyl substituent in 5hmC or from a bridging water in the 5mC structure provide approximately 1.5-2 kcal/mol per interaction of stability to the junction, which is mostly offset by entropy compensation, thereby leaving the overall stability of the G5hmCC and G5mCC constructs similar to that of the GCC core.	5-Methylcytidine 5'-monophosphate	112-115	guanylate cyclase 2C	Homo sapiens	353-356
26138683-10	2016	Fluorescence intensity analysis showed that 5mC level increased after HT-2 toxin exposure, whereas H3K9me2 and H3K27me3 levels decreased after HT-2 toxin exposure, which indicated that DNA and histone methylations were altered.	5-Methylcytidine 5'-monophosphate	44-47	hypothermia due to alcohol sensitivity 2	Mus musculus	70-74
26778509-9	2016	When spring and autumn data were analyzed together, PM2.5, PM10, and NO2 exposures were associated with changes in%5mC (95% CI) in LINE-1, iNOS, p16(CDKN2A), and APC ranging from -0.088 (-0.150, -0.026) to 0.102 (0.049, 0.154) per 1 mug/m(3) increase in the pollutant concentration.	5-Methylcytidine 5'-monophosphate	115-118	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	149-155
25769179-9	2015	For instance, a 3.4-mug/m3 increase in PM2.5 mass concentration was associated with a 0.18%5mC (95% CI: -0.30, -0.06) decrease on the 20th percentile of ICAM-1 methylation, but was not significantly related to the 80th percentile (estimate: 0.07%5mC, 95% CI: -0.09, 0.24).	5-Methylcytidine 5'-monophosphate	91-94	intercellular adhesion molecule 1	Homo sapiens	153-159
26340521-3	2015	(2015) show that Daxx/Atrx repress transposons in ESCs devoid of 5mC, demonstrating dynamic reorganization of epigenetic networks and crosstalk between distinct repressive mechanisms to maintain transposon silencing.	5-Methylcytidine 5'-monophosphate	65-68	death domain associated protein	Homo sapiens	17-21
26340521-3	2015	(2015) show that Daxx/Atrx repress transposons in ESCs devoid of 5mC, demonstrating dynamic reorganization of epigenetic networks and crosstalk between distinct repressive mechanisms to maintain transposon silencing.	5-Methylcytidine 5'-monophosphate	65-68	ATRX chromatin remodeler	Homo sapiens	22-26
26312903-4	2015	We hypothesised that preterm infants have altered 5mC at the linked differentially methylated region 2 (DMR2) of IGF2 and the H19 imprinting control region (H19 ICR) compared with term infants over the first year of life.	5-Methylcytidine 5'-monophosphate	50-53	insulin like growth factor 2	Homo sapiens	113-117
26312903-13	2015	By term-corrected age, preterm infants had decreased %5mC at both DMR2 (beta=-2 84, p=0 013) and the H19 ICR (beta=-2 31, p=0 048) compared with term infants at birth, although this difference disappeared at 1 year.	5-Methylcytidine 5'-monophosphate	54-57	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	72-79
26312903-14	2015	Social deprivation was independently associated with decreased %5mC at DMR2 at birth (beta=-1 73, p=0 006) and term-corrected age (beta=-0 86, p=0 016) but not at 1 year (beta=-0 89, p=0 07).	5-Methylcytidine 5'-monophosphate	64-67	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	86-93
26312903-16	2015	The marked reduction in %5mC at IGF2 DMR2 in preterm infants at birth compared with term-age supports existing evidence that imprinting at secondary regions is established after fertilisation, whereas imprinting is established during gametogenesis at primary regions (H19 ICR).	5-Methylcytidine 5'-monophosphate	25-28	insulin like growth factor 2	Homo sapiens	32-36
25517638-3	2014	However, whether DNA demethylation mediated by TET1, a DNA dioxygenase converting 5-methylcytosine, 5mC, into 5-hydroxymethylcytosine, 5hmC, plays a role in hypoxia-induced EMT is largely unknown.	5-Methylcytidine 5'-monophosphate	100-103	tet methylcytosine dioxygenase 1	Homo sapiens	47-51
26098813-3	2015	In situations of extremely low levels of S-adenosyl methionine (SAM), DNMT-3A and -3B might demethylate C-5 methyl cytosine (5mC) via deamination to thymine, which is subsequently replaced by an unmodified cytosine through the base excision repair (BER) pathway.	5-Methylcytidine 5'-monophosphate	125-128	DNA methyltransferase 3 alpha	Homo sapiens	70-85
26098813-4	2015	Alternatively, 5mC when converted to 5- hydroxymethylcytosine (5hmC) by TET enzymes, might be further modified to an unmodified cytosine by DNMT-3A and -3B under oxidized redox conditions, although exact pathways are yet to be elucidated.	5-Methylcytidine 5'-monophosphate	15-18	DNA methyltransferase 3 alpha	Homo sapiens	140-155
26575259-6	2015	We found that prenatal immune activation increased prefrontal levels of 5-methylated cytosines (5mC) and 5-hydroxymethylated cytosines (5hmC) in the promoter region of GAD1, which encodes the 67-kDa isoform of the GABA-synthesising enzyme glutamic acid decarboxylase (GAD67).	5-Methylcytidine 5'-monophosphate	96-99	glutamate decarboxylase 1	Mus musculus	168-172
26575259-7	2015	The early-life challenge also increased 5mC levels at the promoter region of GAD2, which encodes the 65-kDa GAD isoform (GAD65).	5-Methylcytidine 5'-monophosphate	40-43	glutamic acid decarboxylase 2	Mus musculus	77-81
26575259-7	2015	The early-life challenge also increased 5mC levels at the promoter region of GAD2, which encodes the 65-kDa GAD isoform (GAD65).	5-Methylcytidine 5'-monophosphate	40-43	glutamic acid decarboxylase 2	Mus musculus	121-126
24838624-1	2015	5-Hydroxymethylcytosine (5hmC), converted from 5-methylcytocine (5mC) by Tet family of dioxygenases (Tet1, Tet2, and Tet3), is enriched in the embryonic stem cells (ESCs) and in the brain.	5-Methylcytidine 5'-monophosphate	65-68	tet methylcytosine dioxygenase 1	Homo sapiens	101-105
24838624-1	2015	5-Hydroxymethylcytosine (5hmC), converted from 5-methylcytocine (5mC) by Tet family of dioxygenases (Tet1, Tet2, and Tet3), is enriched in the embryonic stem cells (ESCs) and in the brain.	5-Methylcytidine 5'-monophosphate	65-68	tet methylcytosine dioxygenase 2	Homo sapiens	107-111
24838624-1	2015	5-Hydroxymethylcytosine (5hmC), converted from 5-methylcytocine (5mC) by Tet family of dioxygenases (Tet1, Tet2, and Tet3), is enriched in the embryonic stem cells (ESCs) and in the brain.	5-Methylcytidine 5'-monophosphate	65-68	tet methylcytosine dioxygenase 3	Homo sapiens	117-121
25315069-9	2015	Sustained knockdown of deltaEF1 family proteins reduced the number of 5mC sites in the E-cadherin promoter region, suggesting that these proteins maintain 5mC through interaction with DNMT1 in breast cancer cells.	5-Methylcytidine 5'-monophosphate	70-73	zinc finger E-box binding homeobox 1	Homo sapiens	23-31
25315069-9	2015	Sustained knockdown of deltaEF1 family proteins reduced the number of 5mC sites in the E-cadherin promoter region, suggesting that these proteins maintain 5mC through interaction with DNMT1 in breast cancer cells.	5-Methylcytidine 5'-monophosphate	70-73	cadherin 1	Homo sapiens	87-97
25315069-9	2015	Sustained knockdown of deltaEF1 family proteins reduced the number of 5mC sites in the E-cadherin promoter region, suggesting that these proteins maintain 5mC through interaction with DNMT1 in breast cancer cells.	5-Methylcytidine 5'-monophosphate	70-73	DNA methyltransferase 1	Homo sapiens	184-189
25315069-9	2015	Sustained knockdown of deltaEF1 family proteins reduced the number of 5mC sites in the E-cadherin promoter region, suggesting that these proteins maintain 5mC through interaction with DNMT1 in breast cancer cells.	5-Methylcytidine 5'-monophosphate	155-158	zinc finger E-box binding homeobox 1	Homo sapiens	23-31
25315069-9	2015	Sustained knockdown of deltaEF1 family proteins reduced the number of 5mC sites in the E-cadherin promoter region, suggesting that these proteins maintain 5mC through interaction with DNMT1 in breast cancer cells.	5-Methylcytidine 5'-monophosphate	155-158	cadherin 1	Homo sapiens	87-97
25315069-9	2015	Sustained knockdown of deltaEF1 family proteins reduced the number of 5mC sites in the E-cadherin promoter region, suggesting that these proteins maintain 5mC through interaction with DNMT1 in breast cancer cells.	5-Methylcytidine 5'-monophosphate	155-158	DNA methyltransferase 1	Homo sapiens	184-189
26091021-5	2015	Using specific techniques to map 5mC and 5hmC at DMRs controlling the expression of CDKN1C and the imprinted gene IGF2, we show that 5mC enrichment at KvDMR and DMR0, and 5hmC enrichment within the H19 gene body, associate positively with birth weight.	5-Methylcytidine 5'-monophosphate	33-36	cyclin dependent kinase inhibitor 1C	Homo sapiens	84-90
26091021-5	2015	Using specific techniques to map 5mC and 5hmC at DMRs controlling the expression of CDKN1C and the imprinted gene IGF2, we show that 5mC enrichment at KvDMR and DMR0, and 5hmC enrichment within the H19 gene body, associate positively with birth weight.	5-Methylcytidine 5'-monophosphate	133-136	cyclin dependent kinase inhibitor 1C	Homo sapiens	84-90
26091021-5	2015	Using specific techniques to map 5mC and 5hmC at DMRs controlling the expression of CDKN1C and the imprinted gene IGF2, we show that 5mC enrichment at KvDMR and DMR0, and 5hmC enrichment within the H19 gene body, associate positively with birth weight.	5-Methylcytidine 5'-monophosphate	133-136	insulin like growth factor 2	Homo sapiens	114-118
26091021-5	2015	Using specific techniques to map 5mC and 5hmC at DMRs controlling the expression of CDKN1C and the imprinted gene IGF2, we show that 5mC enrichment at KvDMR and DMR0, and 5hmC enrichment within the H19 gene body, associate positively with birth weight.	5-Methylcytidine 5'-monophosphate	133-136	H19 imprinted maternally expressed transcript	Homo sapiens	198-201
25517638-15	2014	CONCLUSIONS: These findings demonstrate that TET1 serves as a transcription co-activator to regulate hypoxia-responsive gene expression and EMT, in addition to its role in demethylating 5mC.	5-Methylcytidine 5'-monophosphate	186-189	tet methylcytosine dioxygenase 1	Homo sapiens	45-49
27493500-3	2014	In addition, TDG excises 5mC oxidized bases i.e. when X is 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) not 5-hydroxymethylcytosine (5hmC).	5-Methylcytidine 5'-monophosphate	25-28	thymine DNA glycosylase	Homo sapiens	13-16
25263596-0	2014	5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation.	5-Methylcytidine 5'-monophosphate	0-3	tet methylcytosine dioxygenase 2	Homo sapiens	17-21
25179375-3	2014	5mC is distributed across the gene body and appears to facilitate transcription, as transcription is reduced in DNA methyltransferase I (Dnmt1) knockout embryonic stem cells as well as in fibroblasts treated with a methyltransferase inhibitor.	5-Methylcytidine 5'-monophosphate	0-3	DNA methyltransferase 1	Homo sapiens	137-142
27493500-4	2014	A MBD4 inactive mutant and substrate crystal structure clearly explains how MBD4 glycosylase discriminates substrates: 5mC are not able to be directly excised, but a deamination process from 5mC to thymine is required.	5-Methylcytidine 5'-monophosphate	119-122	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	2-6
27493500-4	2014	A MBD4 inactive mutant and substrate crystal structure clearly explains how MBD4 glycosylase discriminates substrates: 5mC are not able to be directly excised, but a deamination process from 5mC to thymine is required.	5-Methylcytidine 5'-monophosphate	119-122	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	76-80
27493500-4	2014	A MBD4 inactive mutant and substrate crystal structure clearly explains how MBD4 glycosylase discriminates substrates: 5mC are not able to be directly excised, but a deamination process from 5mC to thymine is required.	5-Methylcytidine 5'-monophosphate	191-194	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	2-6
27493500-4	2014	A MBD4 inactive mutant and substrate crystal structure clearly explains how MBD4 glycosylase discriminates substrates: 5mC are not able to be directly excised, but a deamination process from 5mC to thymine is required.	5-Methylcytidine 5'-monophosphate	191-194	methyl-CpG binding domain 4, DNA glycosylase	Homo sapiens	76-80
24812327-7	2014	Outside CpG islands, binding of TET1, an enzyme that converts 5mC to 5hmC, is associated with labile, MNase-sensitive nucleosomes.	5-Methylcytidine 5'-monophosphate	62-65	tet methylcytosine dioxygenase 1	Mus musculus	32-36
24812327-10	2014	We rationalize this cell type-dependent targeting of CTCF with a quantitative biophysical model of competitive binding with the histone octamer, depending on the TET1, 5hmC, and 5mC state.	5-Methylcytidine 5'-monophosphate	178-181	CCCTC-binding factor	Mus musculus	53-57
23242216-2	2013	Here we analysed 134 human embryonic and fetal samples from 6 to 20 developmental weeks and identified the stages at which cKIT(+) primordial germ cells (PGCs), the precursors of gametes, undergo whole-genome epigenetic reprogramming with global depletion of 5mC, H3K27me3 and H2A.Z, and the time at which imprint erasure is initiated and 5hmC is present.	5-Methylcytidine 5'-monophosphate	259-262	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	123-127
24655109-2	2014	The Ten-Eleven translocation dioxygenases (TET1, 2, and 3) have been found to oxidize 5mC to 5-hydroxymethylcytosine (5hmC) and then to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in mammalian cells.	5-Methylcytidine 5'-monophosphate	86-89	tet methylcytosine dioxygenase 1	Homo sapiens	43-57
22902005-3	2012	Recent advances have identified key players involved in active demethylation pathways, including oxidation of 5mC to 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) by the TET enzymes, and excision of 5fC by the base excision repair enzyme thymine DNA glycosylase (TDG).	5-Methylcytidine 5'-monophosphate	110-113	thymine DNA glycosylase	Mus musculus	250-273
23149574-2	2012	To establish the distribution in LBCs of MeCP2, one of the key proteins binding 5-methylcytosine-modified DNA (5mC), we expressed HA-tagged MeCP2 constructs in Xenopus laevis oocytes.	5-Methylcytidine 5'-monophosphate	111-114	methyl-CpG binding protein 2 S homeolog	Xenopus laevis	41-46
23149574-5	2012	Expression in oocytes of deleted constructs and of point mutants derived from Rett syndrome patients demonstrated that the association of MeCP2 with LBCs was determined by its 5mC-binding domain.	5-Methylcytidine 5'-monophosphate	176-179	methyl-CpG binding protein 2	Homo sapiens	138-143
22902005-3	2012	Recent advances have identified key players involved in active demethylation pathways, including oxidation of 5mC to 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) by the TET enzymes, and excision of 5fC by the base excision repair enzyme thymine DNA glycosylase (TDG).	5-Methylcytidine 5'-monophosphate	110-113	thymine DNA glycosylase	Mus musculus	275-278
34885145-1	2021	DNA methylation (5-methylcytosine, 5mC) was once viewed as a stable epigenetic modification until Rao and colleagues identified Ten-eleven translocation 1 (TET1) as the first 5mC dioxygenase in 2009.	5-Methylcytidine 5'-monophosphate	35-38	tet methylcytosine dioxygenase 1	Homo sapiens	128-154
22677546-4	2012	In addition, ectopic expression of tumor-derived FH and SDH mutants inhibits histone demethylation and hydroxylation of 5mC.	5-Methylcytidine 5'-monophosphate	120-123	fumarate hydratase	Homo sapiens	49-51
22677546-4	2012	In addition, ectopic expression of tumor-derived FH and SDH mutants inhibits histone demethylation and hydroxylation of 5mC.	5-Methylcytidine 5'-monophosphate	120-123	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	56-59
22560925-5	2012	DNA immunoprecipitation of 5mC and 5hmC indicates that 5mC undergoes conversion to 5hmC prior to activation of p15(ink4b).	5-Methylcytidine 5'-monophosphate	55-58	cyclin dependent kinase inhibitor 2B	Homo sapiens	115-120
19270791-8	2009	iNOS promoter DNA methylation was significantly lower in postexposure blood samples compared with baseline (difference = -0.61 %5mC; p = 0.02).	5-Methylcytidine 5'-monophosphate	128-131	nitric oxide synthase 2	Homo sapiens	0-4
8571376-14	1995	High proportions (> or = 50%) of GGT-->TGT mutations from B[a]P, B[b]F and 5MC induced tumors and GGT-->CGT mutations from CPP tumors were observed and were statistically significant compared to mutations in tricaprylin control tumors.	5-Methylcytidine 5'-monophosphate	81-84	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	45-48
34920255-3	2022	Herein, we proposed a sensitive lanthanide-labelled ICP-MS method for DNA methylation analysis that exploited the feature of Human 8-oxoGuanine DNA Glycosylase (hOGG1), which specifically recognizes 8-oxo-G/5mC base pairs to effectively distinguish methylated DNA.	5-Methylcytidine 5'-monophosphate	207-210	8-oxoguanine DNA glycosylase	Homo sapiens	131-159
34920255-3	2022	Herein, we proposed a sensitive lanthanide-labelled ICP-MS method for DNA methylation analysis that exploited the feature of Human 8-oxoGuanine DNA Glycosylase (hOGG1), which specifically recognizes 8-oxo-G/5mC base pairs to effectively distinguish methylated DNA.	5-Methylcytidine 5'-monophosphate	207-210	8-oxoguanine DNA glycosylase	Homo sapiens	161-166
21750410-4	2011	The recent demonstration that Ten-eleven translocation family proteins, Tet1-3 have the capacity to convert 5mC to 5-hydroxymethylcytosine (5hmC) raises the possibility that 5hmC may act as an distinct epigenetic state contributing to dynamic changes in DNA methylation and transcriptional regulation during embryonic development.	5-Methylcytidine 5'-monophosphate	108-111	tet methylcytosine dioxygenase 1	Mus musculus	72-78
21514197-3	2011	Here we report that Tet1 binds to unmodified C or 5mC- or 5hmC-modified CpG-rich DNA through its CXXC domain.	5-Methylcytidine 5'-monophosphate	50-53	tet methylcytosine dioxygenase 1	Mus musculus	20-24
21514197-6	2011	Collectively, our data suggest that Tet1 controls DNA methylation both by binding to CpG-rich regions to prevent unwanted DNA methyltransferase activity, and by converting 5mC to 5hmC through hydroxylase activity.	5-Methylcytidine 5'-monophosphate	172-175	tet methylcytosine dioxygenase 1	Mus musculus	36-40
21251613-4	2011	Ectopic expression of tumor-derived IDH1 and IDH2 mutants inhibits histone demethylation and 5mC hydroxylation.	5-Methylcytidine 5'-monophosphate	93-96	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	36-40
21251613-4	2011	Ectopic expression of tumor-derived IDH1 and IDH2 mutants inhibits histone demethylation and 5mC hydroxylation.	5-Methylcytidine 5'-monophosphate	93-96	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	45-49
21139069-8	2010	Detection of Tet1 expression specifically and coincidentally, at the time of BER in PGCs, suggests that conversion of 5mC to 5hmC might be involved, at least in part, during epigenetic reprogramming and DNA demethylation in germ cells.	5-Methylcytidine 5'-monophosphate	118-121	tet methylcytosine dioxygenase 1	Mus musculus	13-17
34885145-1	2021	DNA methylation (5-methylcytosine, 5mC) was once viewed as a stable epigenetic modification until Rao and colleagues identified Ten-eleven translocation 1 (TET1) as the first 5mC dioxygenase in 2009.	5-Methylcytidine 5'-monophosphate	35-38	tet methylcytosine dioxygenase 1	Homo sapiens	156-160
34885145-2	2021	TET family genes (including TET1, TET2, and TET3) encode proteins that can catalyze 5mC oxidation and consequently modulate DNA methylation, not only regulating embryonic development and cellular differentiation, but also playing critical roles in various physiological and pathophysiological processes.	5-Methylcytidine 5'-monophosphate	84-87	tet methylcytosine dioxygenase 1	Homo sapiens	28-32
34885145-2	2021	TET family genes (including TET1, TET2, and TET3) encode proteins that can catalyze 5mC oxidation and consequently modulate DNA methylation, not only regulating embryonic development and cellular differentiation, but also playing critical roles in various physiological and pathophysiological processes.	5-Methylcytidine 5'-monophosphate	84-87	tet methylcytosine dioxygenase 2	Homo sapiens	34-38
34885145-2	2021	TET family genes (including TET1, TET2, and TET3) encode proteins that can catalyze 5mC oxidation and consequently modulate DNA methylation, not only regulating embryonic development and cellular differentiation, but also playing critical roles in various physiological and pathophysiological processes.	5-Methylcytidine 5'-monophosphate	84-87	tet methylcytosine dioxygenase 3	Homo sapiens	44-48
35159097-4	2022	During active demethylation, transcription factors (TFs) recruit TET enzymes (TET1, 2, and 3) to specific gene regulatory regions to first catalyze the oxidation of 5mC to 5-hydroxymethylcytosine (5hmC) and subsequently to higher oxidized cytosine derivatives.	5-Methylcytidine 5'-monophosphate	165-168	tet methylcytosine dioxygenase 1	Homo sapiens	78-92
35255956-0	2022	Regulation of paternal 5mC oxidation and H3K9me2 asymmetry by ERK1/2 in mouse zygotes.	5-Methylcytidine 5'-monophosphate	23-26	mitogen-activated protein kinase 3	Mus musculus	62-68
34986190-2	2022	In mouse embryonic stem cells (ESCs), de novo DNAme by DNMT3 family enzymes, demethylation by the TET-mediated conversion of 5mC to 5-hydroxymethylation (5hmC), and maintenance of the remaining DNAme by DNMT1 are actively repeated throughout cell cycles, dynamically forming a constant 5mC profile.	5-Methylcytidine 5'-monophosphate	125-128	DNA methyltransferase (cytosine-5) 1	Mus musculus	203-208