PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28654282-3	2017	After DHPM pretreatment, lower IgE-binding ability of glycated beta-LG was observed with increasing pressures.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	6-10	immunoglobulin heavy constant epsilon	Homo sapiens	31-34
17406591-1	2007	We present here a protocol for the synthesis of the dihydropyrimidine (DHPM) derivative monastrol, which is known to be a specific mitotic kinesin Eg5 inhibitor.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	71-75	kinesin family member 11	Homo sapiens	147-150
34744716-4	2021	Additionally, UV-B exposure increased the expression of cleaved caspase-3, as well as the ratio of Bax/Bcl-2 at protein levels, while pretreatment with DHPM 1 significantly reversed these changes.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	152-156	caspase 3	Homo sapiens	64-73
34744716-4	2021	Additionally, UV-B exposure increased the expression of cleaved caspase-3, as well as the ratio of Bax/Bcl-2 at protein levels, while pretreatment with DHPM 1 significantly reversed these changes.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	152-156	BCL2 associated X, apoptosis regulator	Homo sapiens	99-102
34744716-4	2021	Additionally, UV-B exposure increased the expression of cleaved caspase-3, as well as the ratio of Bax/Bcl-2 at protein levels, while pretreatment with DHPM 1 significantly reversed these changes.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	152-156	BCL2 apoptosis regulator	Homo sapiens	103-108
31323443-3	2019	However, IgE/IgG binding capacities of alpha-LA were decreased after glycation and DHPM pretreatment promoted the reduction.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	83-87	lactalbumin alpha	Bos taurus	39-47
31323443-4	2019	The lowest IgE/IgG binding capacities of glycated alpha-LA were obtained by DHPM pretreatment at 110 MPa.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	76-80	lactalbumin alpha	Bos taurus	50-58
34050874-5	2022	Molecular docking and molecular dynamics (MD) simulations were applied to explore binding potential and realistic binding model of the assessed derivatives through identification of key amino acid residues within L5/alpha2/alpha3 allosteric site of kinesin 5 (Eg5) as a validated microtubule-dependent target for monastrol as a privileged DHPM derivative.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	339-343	kinesin family member 11	Homo sapiens	260-263
27750058-1	2016	Based on the pharmacological importance of dihydropyrimidine (DHPM) scaffold, substituted DHPMs linked with acetamide linker to substituted aromatic anilines were synthesized and evaluated for their potency as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	62-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	210-230
27750058-1	2016	Based on the pharmacological importance of dihydropyrimidine (DHPM) scaffold, substituted DHPMs linked with acetamide linker to substituted aromatic anilines were synthesized and evaluated for their potency as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	62-66	acetylcholinesterase (Cartwright blood group)	Homo sapiens	232-236
27750058-1	2016	Based on the pharmacological importance of dihydropyrimidine (DHPM) scaffold, substituted DHPMs linked with acetamide linker to substituted aromatic anilines were synthesized and evaluated for their potency as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	62-66	butyrylcholinesterase	Homo sapiens	242-263
27750058-1	2016	Based on the pharmacological importance of dihydropyrimidine (DHPM) scaffold, substituted DHPMs linked with acetamide linker to substituted aromatic anilines were synthesized and evaluated for their potency as acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	62-66	butyrylcholinesterase	Homo sapiens	265-269
23323953-1	2014	Abstract A new series of 1,4-dihydropyrimidinone (DHPM) substituted diaryl urea and thiourea derivatives were synthesized and their inhibitory effects on the activity of purified human carbonic anhydrase (hCA) I and II were evaluated.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	50-54	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	185-218
28460991-2	2016	The binding capacity of immunoglobulin E (IgE) from patients" sera with cow"s milk allergy on beta-Lg glycated with galactose decreased after DHPM treatment.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	142-146	immunoglobulin heavy constant epsilon	Homo sapiens	24-40
28460991-2	2016	The binding capacity of immunoglobulin E (IgE) from patients" sera with cow"s milk allergy on beta-Lg glycated with galactose decreased after DHPM treatment.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	142-146	immunoglobulin heavy constant epsilon	Homo sapiens	42-45
28460991-2	2016	The binding capacity of immunoglobulin E (IgE) from patients" sera with cow"s milk allergy on beta-Lg glycated with galactose decreased after DHPM treatment.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	142-146	beta-lactoglobulin	Bos taurus	94-101
28460991-3	2016	beta-Lg treated after different DHPM methods and pressures yielded a significant discrepancy in IgE-binding capacity.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	32-36	beta-lactoglobulin	Bos taurus	0-7
28460991-4	2016	When beta-Lg was pretreated by DHPM, the IgE-binding capacity of beta-Lg-galactose conjugates decreased with increasing pressure; however, the conjugates showed higher IgE-binding capacity at 120MPa than that at 80 and 160MPa when the beta-Lg-galactose mixture was treated by DHPM.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	31-35	beta-lactoglobulin	Bos taurus	5-12
28460991-4	2016	When beta-Lg was pretreated by DHPM, the IgE-binding capacity of beta-Lg-galactose conjugates decreased with increasing pressure; however, the conjugates showed higher IgE-binding capacity at 120MPa than that at 80 and 160MPa when the beta-Lg-galactose mixture was treated by DHPM.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	31-35	immunoglobulin heavy constant epsilon	Homo sapiens	41-44
28460991-4	2016	When beta-Lg was pretreated by DHPM, the IgE-binding capacity of beta-Lg-galactose conjugates decreased with increasing pressure; however, the conjugates showed higher IgE-binding capacity at 120MPa than that at 80 and 160MPa when the beta-Lg-galactose mixture was treated by DHPM.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	31-35	beta-lactoglobulin	Bos taurus	65-72
28460991-4	2016	When beta-Lg was pretreated by DHPM, the IgE-binding capacity of beta-Lg-galactose conjugates decreased with increasing pressure; however, the conjugates showed higher IgE-binding capacity at 120MPa than that at 80 and 160MPa when the beta-Lg-galactose mixture was treated by DHPM.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	31-35	beta-lactoglobulin	Bos taurus	65-72
28460991-4	2016	When beta-Lg was pretreated by DHPM, the IgE-binding capacity of beta-Lg-galactose conjugates decreased with increasing pressure; however, the conjugates showed higher IgE-binding capacity at 120MPa than that at 80 and 160MPa when the beta-Lg-galactose mixture was treated by DHPM.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	276-280	beta-lactoglobulin	Bos taurus	5-12
28460991-4	2016	When beta-Lg was pretreated by DHPM, the IgE-binding capacity of beta-Lg-galactose conjugates decreased with increasing pressure; however, the conjugates showed higher IgE-binding capacity at 120MPa than that at 80 and 160MPa when the beta-Lg-galactose mixture was treated by DHPM.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	276-280	immunoglobulin heavy constant epsilon	Homo sapiens	41-44
28460991-4	2016	When beta-Lg was pretreated by DHPM, the IgE-binding capacity of beta-Lg-galactose conjugates decreased with increasing pressure; however, the conjugates showed higher IgE-binding capacity at 120MPa than that at 80 and 160MPa when the beta-Lg-galactose mixture was treated by DHPM.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	276-280	beta-lactoglobulin	Bos taurus	65-72
28460991-4	2016	When beta-Lg was pretreated by DHPM, the IgE-binding capacity of beta-Lg-galactose conjugates decreased with increasing pressure; however, the conjugates showed higher IgE-binding capacity at 120MPa than that at 80 and 160MPa when the beta-Lg-galactose mixture was treated by DHPM.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	276-280	beta-lactoglobulin	Bos taurus	65-72
28460991-6	2016	The results suggested pretreatment by DHPM and glycation with galactose was a promising approach for eliminating the IgE-binding capacity of beta-Lg.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	38-42	immunoglobulin heavy constant epsilon	Homo sapiens	117-120
28460991-6	2016	The results suggested pretreatment by DHPM and glycation with galactose was a promising approach for eliminating the IgE-binding capacity of beta-Lg.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	38-42	beta-lactoglobulin	Bos taurus	141-148
20538509-1	2010	The interactions between 3,4-dihydropyrimidin-2(1H)-ones (DHPM) and bovine serum albumin (BSA) were investigated by fluorescence and ultraviolet spectroscopy under imitated physiological conditions.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	58-62	albumin	Homo sapiens	75-88
22818437-3	2012	When DHPM pressure increased from 0.1 to 80 MPa, disaggregation of beta-LG samples and partial unfolding of the molecule were accompanied by an increase in beta-LG antigenicity, which was reflected in the decrease of particle size, increase of free sulfhydryl (SH) contents and beta-strands contents, and slight exposure of aromatic amino acid residues.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	5-9	beta-lactoglobulin	Bos taurus	67-74
22818437-3	2012	When DHPM pressure increased from 0.1 to 80 MPa, disaggregation of beta-LG samples and partial unfolding of the molecule were accompanied by an increase in beta-LG antigenicity, which was reflected in the decrease of particle size, increase of free sulfhydryl (SH) contents and beta-strands contents, and slight exposure of aromatic amino acid residues.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	5-9	beta-lactoglobulin	Bos taurus	156-163
22818437-5	2012	Aggregation and conformational changes of beta-LG under DHPM was related to its antigenicity.	ethyl 6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxylate	56-60	beta-lactoglobulin	Bos taurus	42-49