PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32104074-11	2020	CircHIPK3 served as a sponge for miR-330-5p, and miR-330-5p directly bound to the 3" UTR of RASSF1 were revealed by dual luciferase assay and RIP in PC cells.	CHEMBL3740941	41-43	microRNA 330	Homo sapiens	33-40
32201519-11	2020	Results: FOXA1 suppressed the expression of miR-100-5p and miR-125b-5p in NPC cells.	CHEMBL3740941	52-54	forkhead box A1	Homo sapiens	9-14
32099397-3	2020	Methods: MiR-195-5p and YAP1 were detected using qRT-PCR in cervical cancer cells transfected with miR-195-5p mimics or inhibitor.	CHEMBL3740941	17-19	microRNA 195	Homo sapiens	9-16
32024541-12	2020	Our in vitro studies reveal that miR-876-5p directly targets CREB5.	CHEMBL3740941	41-43	cAMP responsive element binding protein 5	Homo sapiens	61-66
32048632-9	2020	<strong>RESULTS</strong> MiR-218-5p level was notably increased in OGD/R injured PC12 cells and directly targeted NDRG4.	CHEMBL3740941	33-35	NDRG family member 4	Rattus norvegicus	114-119
32096148-7	2020	The rescue experiment was finally conducted to validate the miR-26a-5p-dependent mechanism on cell proliferation, migration, and invasion via targeting COL10A1.	CHEMBL3740941	68-70	collagen type X alpha 1 chain	Homo sapiens	152-159
32099397-3	2020	Methods: MiR-195-5p and YAP1 were detected using qRT-PCR in cervical cancer cells transfected with miR-195-5p mimics or inhibitor.	CHEMBL3740941	17-19	microRNA 195	Homo sapiens	99-106
32513089-11	2020	However, the BMSC effect was significantly occluded by the pretreatment with miR-547-5p agomir or the IL-33 knockdown, demonstrating a novel mechanism underlying the BMSC therapy.	CHEMBL3740941	85-87	microRNA 547	Rattus norvegicus	77-84
31144303-6	2020	RNA immunoprecipitation indicated that LINC01116 and VEGFA were present in the miR-31-5p-RISC complex, and biotinylated miR-31-5p pull-down assay suggested that there was a competitive relationship between LINC01116 and VEGFA to bind with miR-31-5p.	CHEMBL3740941	86-88	long intergenic non-protein coding RNA 1116	Homo sapiens	39-48
31144303-6	2020	RNA immunoprecipitation indicated that LINC01116 and VEGFA were present in the miR-31-5p-RISC complex, and biotinylated miR-31-5p pull-down assay suggested that there was a competitive relationship between LINC01116 and VEGFA to bind with miR-31-5p.	CHEMBL3740941	86-88	vascular endothelial growth factor A	Homo sapiens	53-58
31144303-6	2020	RNA immunoprecipitation indicated that LINC01116 and VEGFA were present in the miR-31-5p-RISC complex, and biotinylated miR-31-5p pull-down assay suggested that there was a competitive relationship between LINC01116 and VEGFA to bind with miR-31-5p.	CHEMBL3740941	86-88	microRNA 31	Homo sapiens	79-85
33327889-14	2020	CONCLUSIONS: Inhibition of miR-766-5p restrains the cell proliferation, migration and invasion, and promotes the apoptosis in CC through negatively regulating SCAI.	CHEMBL3740941	35-37	microRNA 766	Homo sapiens	27-34
33327889-14	2020	CONCLUSIONS: Inhibition of miR-766-5p restrains the cell proliferation, migration and invasion, and promotes the apoptosis in CC through negatively regulating SCAI.	CHEMBL3740941	35-37	suppressor of cancer cell invasion	Homo sapiens	159-163
31074036-14	2019	miR-423-5p depletion led to the activation of the wnt/beta-catenin signaling pathway via targeting MYBL2.	CHEMBL3740941	8-10	microRNA 423	Homo sapiens	0-7
31074036-14	2019	miR-423-5p depletion led to the activation of the wnt/beta-catenin signaling pathway via targeting MYBL2.	CHEMBL3740941	8-10	catenin beta 1	Homo sapiens	54-66
31074036-14	2019	miR-423-5p depletion led to the activation of the wnt/beta-catenin signaling pathway via targeting MYBL2.	CHEMBL3740941	8-10	MYB proto-oncogene like 2	Homo sapiens	99-104
31607309-7	2019	The miR-28-5p target CCND1 was expressed at high levels in MM patients with LPP / miR-28-5p methylation, the expression level of miR-28-5p in MM patients correlated with beta2-MG concentration.	CHEMBL3740941	11-13	ATPase H+ transporting V0 subunit a2	Homo sapiens	170-175
31858556-14	2019	Furthermore, miR-628-5p inhibitor abolished circ-0001801 silencing-mediated inhibition of cell progression in GBM.	CHEMBL3740941	21-23	microRNA 628	Homo sapiens	13-20
31111544-5	2019	Then, we found that miR-628-5p directly bound to the 3"-untranslated region of DDX59 and decreased the protein level of DDX59.	CHEMBL3740941	28-30	microRNA 628	Homo sapiens	20-27
31111544-5	2019	Then, we found that miR-628-5p directly bound to the 3"-untranslated region of DDX59 and decreased the protein level of DDX59.	CHEMBL3740941	28-30	DEAD-box helicase 59	Homo sapiens	79-84
31111544-5	2019	Then, we found that miR-628-5p directly bound to the 3"-untranslated region of DDX59 and decreased the protein level of DDX59.	CHEMBL3740941	28-30	DEAD-box helicase 59	Homo sapiens	120-125
31607309-7	2019	The miR-28-5p target CCND1 was expressed at high levels in MM patients with LPP / miR-28-5p methylation, the expression level of miR-28-5p in MM patients correlated with beta2-MG concentration.	CHEMBL3740941	11-13	microRNA 28	Homo sapiens	4-10
31528235-7	2019	Dock1 overexpression reversed the effect caused by the overexpression of miR-486-5p.	CHEMBL3740941	81-83	dedicator of cytokinesis 1	Mus musculus	0-5
31607309-7	2019	The miR-28-5p target CCND1 was expressed at high levels in MM patients with LPP / miR-28-5p methylation, the expression level of miR-28-5p in MM patients correlated with beta2-MG concentration.	CHEMBL3740941	11-13	cyclin D1	Homo sapiens	21-26
31607309-7	2019	The miR-28-5p target CCND1 was expressed at high levels in MM patients with LPP / miR-28-5p methylation, the expression level of miR-28-5p in MM patients correlated with beta2-MG concentration.	CHEMBL3740941	11-13	microRNA 28	Homo sapiens	82-88
31607309-7	2019	The miR-28-5p target CCND1 was expressed at high levels in MM patients with LPP / miR-28-5p methylation, the expression level of miR-28-5p in MM patients correlated with beta2-MG concentration.	CHEMBL3740941	11-13	microRNA 28	Homo sapiens	82-88
31501407-12	2019	CONCLUSIONS The miR-486-5p/KIAA1199/EMT axis might play a critical role in PTC invasion and metastasis and offers a potential therapeutic strategy for PTC.	CHEMBL3740941	24-26	cell migration inducing hyaluronidase 1	Homo sapiens	27-35
31172560-9	2019	miR-181c-5p was found to be decreased while IL1A was increased in IBS rats.	CHEMBL3740941	9-11	microRNA 181c	Rattus norvegicus	0-8
31455213-7	2019	MiR-423-5p exerts its effect on HG-induced apoptosis in RPE cells through TFF1, and the NF-kappaB pathway is involved in the regulatory mechanism.	CHEMBL3740941	8-10	microRNA 423	Homo sapiens	0-7
31455213-7	2019	MiR-423-5p exerts its effect on HG-induced apoptosis in RPE cells through TFF1, and the NF-kappaB pathway is involved in the regulatory mechanism.	CHEMBL3740941	8-10	trefoil factor 1	Homo sapiens	74-78
31119262-0	2019	Corrigendum to: miR-188-5p regulates proliferation and invasion via PI3K/Akt/MMP-2/9 signaling in keloids.	CHEMBL3740941	24-26	AKT serine/threonine kinase 1	Homo sapiens	73-76
31119262-0	2019	Corrigendum to: miR-188-5p regulates proliferation and invasion via PI3K/Akt/MMP-2/9 signaling in keloids.	CHEMBL3740941	24-26	matrix metallopeptidase 2	Homo sapiens	77-82
31322197-4	2019	The results obtained revealed that miR-195-5p acted as a tumor suppressor in SQCLC cells.	CHEMBL3740941	43-45	microRNA 195	Homo sapiens	35-42
31316614-10	2019	miR-125a-5p upregulation inhibited PLC/PRF/5 cell viability and migration and induced cell apoptosis.	CHEMBL3740941	9-11	heparan sulfate proteoglycan 2	Homo sapiens	35-38
31534537-7	2019	Bioinformatics analysis, Western blotting and luciferase reporter analysis were employed to examine the relationship between miR-33a-5p and its potential targets.	CHEMBL3740941	133-135	MLX interacting protein	Homo sapiens	125-128
31398705-3	2019	METHODS: Adult male Sprague-Dawley rats were subjected to microsurgery to create a coiled embolization aneurysm model, and were injected with miR-31a-5p agomir or a negative control agomir via the tail vein at a dose of 10 mg/kg per week for 4 weeks after IA induction.	CHEMBL3740941	150-152	microRNA 31	Rattus norvegicus	142-149
31363375-11	2019	The results revealed that miR-140-5p expression was significantly downregulated in NSCLC tissues compared with matched normal tissues.	CHEMBL3740941	34-36	microRNA 140	Homo sapiens	26-33
31316614-12	2019	Notably, the present study revealed that all the effects on PLC/PRF/5 cells elicited by miR-125a-5p overexpression were eliminated by TRIAP1/BCL2L2 upregulation.	CHEMBL3740941	97-99	heparan sulfate proteoglycan 2	Homo sapiens	60-63
31316614-12	2019	Notably, the present study revealed that all the effects on PLC/PRF/5 cells elicited by miR-125a-5p overexpression were eliminated by TRIAP1/BCL2L2 upregulation.	CHEMBL3740941	97-99	TP53 regulated inhibitor of apoptosis 1	Homo sapiens	134-140
31316614-12	2019	Notably, the present study revealed that all the effects on PLC/PRF/5 cells elicited by miR-125a-5p overexpression were eliminated by TRIAP1/BCL2L2 upregulation.	CHEMBL3740941	97-99	BCL2 like 2	Homo sapiens	141-147
30950325-5	2019	The osteogenic capacity of Gli2-knockdown BMSCs was rejuvenated by miR-384-5p inhibition.	CHEMBL3740941	75-77	GLI family zinc finger 2	Rattus norvegicus	27-31
30951775-7	2019	Among these miRNAs, miR-203a-5p expression was significantly decreased by TGF-beta1-treatment in rat osteoblasts.	CHEMBL3740941	29-31	transforming growth factor, beta 1	Rattus norvegicus	74-83
31077718-11	2019	Downregulation of MMP-13 and ADAMTS-5 in 5-AzadC-treated OA chondrocytes was prevented by miR-140-5p inhibitor transfection.	CHEMBL3740941	98-100	matrix metallopeptidase 13	Homo sapiens	18-24
31077718-11	2019	Downregulation of MMP-13 and ADAMTS-5 in 5-AzadC-treated OA chondrocytes was prevented by miR-140-5p inhibitor transfection.	CHEMBL3740941	98-100	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	29-37
31077718-11	2019	Downregulation of MMP-13 and ADAMTS-5 in 5-AzadC-treated OA chondrocytes was prevented by miR-140-5p inhibitor transfection.	CHEMBL3740941	98-100	microRNA 140	Homo sapiens	90-97
31297133-10	2019	At the molecular level, we further found that TCTN1 overexpression reversed the effects of miR-216a-5p transfection on the expression of PCNA, Bcl-2 and Bad.	CHEMBL3740941	100-102	tectonic family member 1	Homo sapiens	46-51
31297133-10	2019	At the molecular level, we further found that TCTN1 overexpression reversed the effects of miR-216a-5p transfection on the expression of PCNA, Bcl-2 and Bad.	CHEMBL3740941	100-102	proliferating cell nuclear antigen	Homo sapiens	137-141
31297133-10	2019	At the molecular level, we further found that TCTN1 overexpression reversed the effects of miR-216a-5p transfection on the expression of PCNA, Bcl-2 and Bad.	CHEMBL3740941	100-102	BCL2 apoptosis regulator	Homo sapiens	143-148
31378888-12	2019	CONCLUSIONS: The overexpression of miR-195-5p can inhibit YAP-mediated Wnt/beta-catenin signaling pathway and promote cell apoptosis, so it may be a potential therapeutic target for GC.	CHEMBL3740941	43-45	membrane associated ring-CH-type finger 8	Homo sapiens	35-38
31378888-12	2019	CONCLUSIONS: The overexpression of miR-195-5p can inhibit YAP-mediated Wnt/beta-catenin signaling pathway and promote cell apoptosis, so it may be a potential therapeutic target for GC.	CHEMBL3740941	43-45	Yes1 associated transcriptional regulator	Homo sapiens	58-61
31378888-12	2019	CONCLUSIONS: The overexpression of miR-195-5p can inhibit YAP-mediated Wnt/beta-catenin signaling pathway and promote cell apoptosis, so it may be a potential therapeutic target for GC.	CHEMBL3740941	43-45	catenin beta 1	Homo sapiens	75-87
31173209-8	2019	These results demonstrated that miR-26b-5p may exert antitumor activity.	CHEMBL3740941	40-42	microRNA 26b	Homo sapiens	32-39
31384178-8	2019	Moreover, dual luciferase-reporter assays revealed that miR-125b-5p targets TXNRD1 to directly regulate its expression, whereas TXNRD1 overexpression abolishes the inhibitory effect of miR-125b-5p on HCC cell proliferation, migration, and invasion.	CHEMBL3740941	65-67	thioredoxin reductase 1	Homo sapiens	76-82
31384178-8	2019	Moreover, dual luciferase-reporter assays revealed that miR-125b-5p targets TXNRD1 to directly regulate its expression, whereas TXNRD1 overexpression abolishes the inhibitory effect of miR-125b-5p on HCC cell proliferation, migration, and invasion.	CHEMBL3740941	65-67	HCC	Homo sapiens	200-203
31417288-9	2019	Results: We found that miR-382-5p levels were low in glioma tissues as determined by qRT-PCR.	CHEMBL3740941	31-33	microRNA 382	Homo sapiens	23-30
31354360-16	2019	miR-382-5p transfection reversed the tumor-promoting role by SNHG1.	CHEMBL3740941	8-10	microRNA 382	Homo sapiens	0-7
31354360-16	2019	miR-382-5p transfection reversed the tumor-promoting role by SNHG1.	CHEMBL3740941	8-10	small nucleolar RNA host gene 1	Homo sapiens	61-66
30950325-5	2019	The osteogenic capacity of Gli2-knockdown BMSCs was rejuvenated by miR-384-5p inhibition.	CHEMBL3740941	75-77	microRNA 384	Rattus norvegicus	67-74
30922080-6	2019	miR-574-5p-induced tumor growth in mice could be completely inhibited with the mPGES-1 inhibitor CIII.	CHEMBL3740941	8-10	prostaglandin E synthase	Mus musculus	79-86
31185006-9	2019	THP-1 cells treated with miR-30c-5p agomir and miR-30c-5p antagomir were measured with quantitative reverse transcription-polymerase chain reaction.	CHEMBL3740941	33-35	membrane associated ring-CH-type finger 8	Rattus norvegicus	25-28
31185006-9	2019	THP-1 cells treated with miR-30c-5p agomir and miR-30c-5p antagomir were measured with quantitative reverse transcription-polymerase chain reaction.	CHEMBL3740941	55-57	membrane associated ring-CH-type finger 8	Rattus norvegicus	47-50
31185006-14	2019	CONCLUSIONS We preliminarily demonstrated that miR-30c-5p agomir might decrease renal I/R through transformation of M1 macrophages to M2 macrophages and resulted in changes in inflammatory cytokines.	CHEMBL3740941	55-57	membrane associated ring-CH-type finger 8	Rattus norvegicus	47-50
30480801-3	2019	This study aimed to explore the effect of miR-99b-5p (miR-99b) on invasion and migration in cervical cancer through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway.	CHEMBL3740941	50-52	microRNA 99b	Homo sapiens	42-49
30362537-10	2019	Next, we predicted that Six1 was a potential target gene of miR-448-5p and demonstrated that miR-448-5p could directly target Six1.	CHEMBL3740941	68-70	sine oculis-related homeobox 1	Mus musculus	24-28
30362537-10	2019	Next, we predicted that Six1 was a potential target gene of miR-448-5p and demonstrated that miR-448-5p could directly target Six1.	CHEMBL3740941	68-70	microRNA 448	Mus musculus	60-67
30362537-10	2019	Next, we predicted that Six1 was a potential target gene of miR-448-5p and demonstrated that miR-448-5p could directly target Six1.	CHEMBL3740941	68-70	microRNA 448	Mus musculus	93-100
30942430-7	2019	BITC treatment significantly upregulated miR-99a-5p levels in a dose-dependent manner.	CHEMBL3740941	49-51	membrane associated ring-CH-type finger 8	Homo sapiens	41-44
30480801-3	2019	This study aimed to explore the effect of miR-99b-5p (miR-99b) on invasion and migration in cervical cancer through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway.	CHEMBL3740941	50-52	microRNA 99b	Homo sapiens	54-61
30480801-3	2019	This study aimed to explore the effect of miR-99b-5p (miR-99b) on invasion and migration in cervical cancer through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway.	CHEMBL3740941	50-52	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	120-149
30480801-3	2019	This study aimed to explore the effect of miR-99b-5p (miR-99b) on invasion and migration in cervical cancer through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway.	CHEMBL3740941	50-52	protein tyrosine kinase 2 beta	Homo sapiens	157-173
30480801-3	2019	This study aimed to explore the effect of miR-99b-5p (miR-99b) on invasion and migration in cervical cancer through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway.	CHEMBL3740941	50-52	AKT serine/threonine kinase 1	Homo sapiens	175-178
30480801-3	2019	This study aimed to explore the effect of miR-99b-5p (miR-99b) on invasion and migration in cervical cancer through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway.	CHEMBL3740941	50-52	mechanistic target of rapamycin kinase	Homo sapiens	180-211
30480801-3	2019	This study aimed to explore the effect of miR-99b-5p (miR-99b) on invasion and migration in cervical cancer through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway.	CHEMBL3740941	50-52	mechanistic target of rapamycin kinase	Homo sapiens	213-217
31275059-8	2019	Further findings pointed out that hucMSCs transfected with miR148b-5p mimics could be elevated to promote the tissue repair and inhibit the expression of 15-lox-1 but failed to perform the function of easing enteritis when treated with miR148b-5p inhibitors.	CHEMBL3740941	67-69	microRNA 148b	Mus musculus	59-66
31059100-14	2019	In addition, overexpression of miR-30a-5p induced apoptosis by targeting B-cell lymphoma 2, which was similar to that observed in response to TSA.	CHEMBL3740941	39-41	microRNA 30a	Homo sapiens	31-38
31085811-7	2019	More interestingly, the protective actions of lncRNA GAS5 silence on hypoxia-stimulated cells were attenuated by miR-142-5p suppression.	CHEMBL3740941	121-123	growth arrest specific 5	Rattus norvegicus	53-57
31068824-7	2019	OIP5-AS1 knockdown suppressed the proliferation, migration, and invasion of HemECs cell, while overexpression of OIP5-AS1 had opposite effects LncRNA OIP5-AS1 acted as a ceRNA through binding with miR-195-5p to upregulate NOB1 in HemECs.	CHEMBL3740941	205-207	Opa interacting protein 5	Homo sapiens	0-4
30777616-6	2019	MiR-125a-5p inhibitor attenuated ANRIL knockdown-induced chemosensitivity to cisplatin.	CHEMBL3740941	9-11	CDKN2B antisense RNA 1	Homo sapiens	33-38
30844685-11	2019	In addition, BMSC-exo repressed the expression of PTEN in H9C2 cells via miR-486-5p, and subsequently activated the PI3K/AKT pathway in vitro.	CHEMBL3740941	81-83	phosphatase and tensin homolog	Rattus norvegicus	50-54
31068824-7	2019	OIP5-AS1 knockdown suppressed the proliferation, migration, and invasion of HemECs cell, while overexpression of OIP5-AS1 had opposite effects LncRNA OIP5-AS1 acted as a ceRNA through binding with miR-195-5p to upregulate NOB1 in HemECs.	CHEMBL3740941	205-207	prostaglandin D2 receptor	Homo sapiens	5-8
31068824-7	2019	OIP5-AS1 knockdown suppressed the proliferation, migration, and invasion of HemECs cell, while overexpression of OIP5-AS1 had opposite effects LncRNA OIP5-AS1 acted as a ceRNA through binding with miR-195-5p to upregulate NOB1 in HemECs.	CHEMBL3740941	205-207	OIP5 antisense RNA 1	Homo sapiens	0-8
31068824-7	2019	OIP5-AS1 knockdown suppressed the proliferation, migration, and invasion of HemECs cell, while overexpression of OIP5-AS1 had opposite effects LncRNA OIP5-AS1 acted as a ceRNA through binding with miR-195-5p to upregulate NOB1 in HemECs.	CHEMBL3740941	205-207	OIP5 antisense RNA 1	Homo sapiens	113-121
31068824-7	2019	OIP5-AS1 knockdown suppressed the proliferation, migration, and invasion of HemECs cell, while overexpression of OIP5-AS1 had opposite effects LncRNA OIP5-AS1 acted as a ceRNA through binding with miR-195-5p to upregulate NOB1 in HemECs.	CHEMBL3740941	205-207	microRNA 195	Homo sapiens	197-204
30982780-6	2019	PNPO was down-regulated and up-regulated by miR-216b-5p mimics and inhibitors, respectively, in breast cancer cells.	CHEMBL3740941	53-55	pyridoxamine 5'-phosphate oxidase	Homo sapiens	0-4
30575977-8	2019	In rat pulpitis models, the injection of let-7c-5p agomir restored the osteogenic differentiation potential of dental pulp cells and inhibited HMGA2/PI3K/Akt signalling.	CHEMBL3740941	48-50	high mobility group AT-hook 2	Rattus norvegicus	143-148
31105832-9	2019	In a word, our study found that miR-186-5p could inhibit tumor proliferation by targeting Eg5 in neuroblastoma.	CHEMBL3740941	40-42	kinesin family member 11	Homo sapiens	90-93
30575977-8	2019	In rat pulpitis models, the injection of let-7c-5p agomir restored the osteogenic differentiation potential of dental pulp cells and inhibited HMGA2/PI3K/Akt signalling.	CHEMBL3740941	48-50	AKT serine/threonine kinase 1	Rattus norvegicus	154-157
30628643-9	2019	Rescue experiments demonstrated that suppression of MTDH restored the effect of miR-3664-5P inhibitors on GC cell lines.	CHEMBL3740941	89-91	metadherin	Homo sapiens	52-56
30672645-9	2019	In additional, we found there were classical and evolutionarily conserved miR-138-5p binding sites in 3"-UTR region of SIRT1, which was inhibited when overexpression of miR-138-5p.	CHEMBL3740941	82-84	sirtuin 1	Homo sapiens	119-124
30193893-4	2019	Here we identified an increase in miR-324-5p expression in OA cartilage and hypothesised that, as in glioma, miR-324-5p would regulate Hh signalling.	CHEMBL3740941	42-44	microRNA 324	Mus musculus	34-41
30193893-4	2019	Here we identified an increase in miR-324-5p expression in OA cartilage and hypothesised that, as in glioma, miR-324-5p would regulate Hh signalling.	CHEMBL3740941	42-44	microRNA 324	Mus musculus	109-116
30668319-18	2019	CONCLUSION: These findings indicated that miR-6809-5p mediates the growth-suppressive activity of luteolin in HCC, which is causally linked to FLOT1 downregulation.	CHEMBL3740941	51-53	flotillin 1	Homo sapiens	143-148
30628643-9	2019	Rescue experiments demonstrated that suppression of MTDH restored the effect of miR-3664-5P inhibitors on GC cell lines.	CHEMBL3740941	89-91	microRNA 615	Mus musculus	80-83
30643918-5	2019	In L-02 cells, arsenite caused increases of GSDMD and cleaved caspase-1 levels and decreases of caspase-1 and miR-379-5p levels.	CHEMBL3740941	118-120	microRNA 379	Homo sapiens	110-117
31128012-11	2019	Knockdown of miR-660-5p significantly suppressed proliferation, migration, and invasion, whereas overexpression of miR-660-5p had the opposite effect.	CHEMBL3740941	21-23	microRNA 660	Homo sapiens	13-20
30961681-8	2019	The effects of miR-205-5p overexpression on cell proliferation and migration can be reversed by CBX1 overexpression.	CHEMBL3740941	23-25	microRNA 205	Homo sapiens	15-22
30961681-8	2019	The effects of miR-205-5p overexpression on cell proliferation and migration can be reversed by CBX1 overexpression.	CHEMBL3740941	23-25	chromobox 1	Homo sapiens	96-100
29422114-7	2019	These effects were consistent with the cells transfected with miR-18a-5p inhibitor.	CHEMBL3740941	70-72	microRNA 18a	Homo sapiens	62-69
31365693-2	2019	The present study aimed to investigate the role of miR-383-5p in gastric carcinogenesis.	CHEMBL3740941	59-61	microRNA 383	Homo sapiens	51-58
30863103-13	2019	Additionally, PAK1 was identified as a direct target of miR-140-5p.	CHEMBL3740941	64-66	p21 (RAC1) activated kinase 1	Mus musculus	14-18
30551476-5	2019	Dual luciferase reporter assay, quantitative real-time PCR (qRT-PCR) and Western blotting were performed to demonstrate that miR-181b-5p directly targets Bcl-2 to reduce the expression.	CHEMBL3740941	134-136	BCL2 apoptosis regulator	Homo sapiens	154-159
31490755-0	2019	MiR-125b-5p inhibitor might protect against sevoflurane-induced cognitive impairments by targeting to LIMK1.	CHEMBL3740941	9-11	LIM domain kinase 1	Rattus norvegicus	102-107
30243568-4	2019	Our research aims to analyze the relationship between miR-218-5p and Epidermal Growth Factor Receptor (EGFR) in human pterygium tissues and cultured Human Pterygium Epithelial Cells (hPECs).	CHEMBL3740941	62-64	epidermal growth factor receptor	Homo sapiens	69-101
31677258-15	2019	Dual-luciferase reporter assay system shows the 3"-UTR segments of SFN containing miR-675-5p binding sites.	CHEMBL3740941	90-92	RNA exonuclease 2	Homo sapiens	67-70
31677258-15	2019	Dual-luciferase reporter assay system shows the 3"-UTR segments of SFN containing miR-675-5p binding sites.	CHEMBL3740941	90-92	microRNA 675	Homo sapiens	82-89
30243568-4	2019	Our research aims to analyze the relationship between miR-218-5p and Epidermal Growth Factor Receptor (EGFR) in human pterygium tissues and cultured Human Pterygium Epithelial Cells (hPECs).	CHEMBL3740941	62-64	epidermal growth factor receptor	Homo sapiens	103-107
30057417-13	2018	The results support the view that inhibition of miR-384-5p could impede apoptosis and promote proliferation of cartilage cells through activating the NF-kappaB signaling pathway by promoting SOX9, thereby preventing the development of OA.	CHEMBL3740941	56-58	microRNA 384	Mus musculus	48-55
30323063-10	2018	Of note, miR-664-5p"s inhibitory effect on myogenic differentiation was abrogated by treatment with Wnt1 protein, the key activator of the Wnt/beta-catenin signaling pathway.	CHEMBL3740941	17-19	wingless-type MMTV integration site family, member 1	Mus musculus	100-104
30323063-10	2018	Of note, miR-664-5p"s inhibitory effect on myogenic differentiation was abrogated by treatment with Wnt1 protein, the key activator of the Wnt/beta-catenin signaling pathway.	CHEMBL3740941	17-19	wingless-type MMTV integration site family, member 1	Mus musculus	100-103
30323063-10	2018	Of note, miR-664-5p"s inhibitory effect on myogenic differentiation was abrogated by treatment with Wnt1 protein, the key activator of the Wnt/beta-catenin signaling pathway.	CHEMBL3740941	17-19	catenin (cadherin associated protein), beta 1	Mus musculus	143-155
30057417-13	2018	The results support the view that inhibition of miR-384-5p could impede apoptosis and promote proliferation of cartilage cells through activating the NF-kappaB signaling pathway by promoting SOX9, thereby preventing the development of OA.	CHEMBL3740941	56-58	SRY (sex determining region Y)-box 9	Mus musculus	191-195
30348524-13	2018	Moreover, phosphorylation of PI3K/AKT/mTOR pathway was activated by miR-129-5p overexpression or ATG14 inhibition to alleviate the autophagy and apoptosis in H2O2-induced H9c2 cells.	CHEMBL3740941	76-78	AKT serine/threonine kinase 1	Rattus norvegicus	34-37
30171660-10	2018	Suppression of WTAPP1 by miR-3120-5P decreased the level of MMP-1.	CHEMBL3740941	34-36	matrix metallopeptidase 1	Homo sapiens	60-65
30348524-13	2018	Moreover, phosphorylation of PI3K/AKT/mTOR pathway was activated by miR-129-5p overexpression or ATG14 inhibition to alleviate the autophagy and apoptosis in H2O2-induced H9c2 cells.	CHEMBL3740941	76-78	mechanistic target of rapamycin kinase	Rattus norvegicus	38-42
30510488-12	2018	However, the IL-10 and TLR4 mRNA levels were upregulated in purified T cells from spleen and lymph nodes after treatment with miR-30b-5p antagonist.	CHEMBL3740941	134-136	interleukin 10	Rattus norvegicus	13-18
30221720-8	2018	Overexpression of miR-224-5p significantly inhibited U251 cell proliferation and induced cellular apoptosis; this effect was clearly reversed following co-transfection of miR-224-5p and TPD52.	CHEMBL3740941	26-28	microRNA 224	Homo sapiens	18-25
30221720-8	2018	Overexpression of miR-224-5p significantly inhibited U251 cell proliferation and induced cellular apoptosis; this effect was clearly reversed following co-transfection of miR-224-5p and TPD52.	CHEMBL3740941	26-28	microRNA 224	Homo sapiens	171-178
30221720-8	2018	Overexpression of miR-224-5p significantly inhibited U251 cell proliferation and induced cellular apoptosis; this effect was clearly reversed following co-transfection of miR-224-5p and TPD52.	CHEMBL3740941	26-28	tumor protein D52	Homo sapiens	186-191
30425531-14	2018	miR-593-5p also downregulated FAK, MMP12, and JUN protein expression.	CHEMBL3740941	8-10	microRNA 593	Homo sapiens	0-7
30425531-14	2018	miR-593-5p also downregulated FAK, MMP12, and JUN protein expression.	CHEMBL3740941	8-10	matrix metallopeptidase 12	Homo sapiens	35-40
30305681-6	2018	The area under the curve (AUC) for miR-323b-5p + confounding risk factors was 0.94 (95% CI: 0.884-0.994, P &lt; 0.001), which was higher than that for miR-323b-5p.	CHEMBL3740941	44-46	microRNA 323b	Homo sapiens	35-43
30305681-6	2018	The area under the curve (AUC) for miR-323b-5p + confounding risk factors was 0.94 (95% CI: 0.884-0.994, P &lt; 0.001), which was higher than that for miR-323b-5p.	CHEMBL3740941	44-46	microRNA 323b	Homo sapiens	151-159
30063117-4	2018	We have been suggested that exosomes derived from AC-miR-95-5p (AC-miR-95-5p-Exos) would enhance chondrogenesis and prevent the development of osteoarthritis by directly targeting HDAC2/8.	CHEMBL3740941	60-62	microRNA 95	Homo sapiens	53-59
30063117-4	2018	We have been suggested that exosomes derived from AC-miR-95-5p (AC-miR-95-5p-Exos) would enhance chondrogenesis and prevent the development of osteoarthritis by directly targeting HDAC2/8.	CHEMBL3740941	60-62	microRNA 95	Homo sapiens	67-73
30063117-4	2018	We have been suggested that exosomes derived from AC-miR-95-5p (AC-miR-95-5p-Exos) would enhance chondrogenesis and prevent the development of osteoarthritis by directly targeting HDAC2/8.	CHEMBL3740941	60-62	histone deacetylase 2	Homo sapiens	180-185
29960070-1	2018	MiR-361-5p has been reported to be dysregulated in several types of cancers.	CHEMBL3740941	8-10	microRNA 361	Mus musculus	0-7
30410355-8	2018	qRT-PCR was performed to detect the miR-10a-5p level.	CHEMBL3740941	44-46	microRNA 10a	Homo sapiens	36-43
30510488-12	2018	However, the IL-10 and TLR4 mRNA levels were upregulated in purified T cells from spleen and lymph nodes after treatment with miR-30b-5p antagonist.	CHEMBL3740941	134-136	toll-like receptor 4	Rattus norvegicus	23-27
30250022-5	2018	Moreover, ZFAS1 and VEGFA are both targets of miR-150-5p, while ZFAS1 binds to miR-150-5p in an AGO2-dependent manner.	CHEMBL3740941	54-56	ZNFX1 antisense RNA 1	Homo sapiens	10-15
30402831-11	2018	The luciferase assay showed MMP-2 was the target gene of miR-517-5p.	CHEMBL3740941	65-67	matrix metallopeptidase 2	Homo sapiens	28-33
30250022-5	2018	Moreover, ZFAS1 and VEGFA are both targets of miR-150-5p, while ZFAS1 binds to miR-150-5p in an AGO2-dependent manner.	CHEMBL3740941	54-56	vascular endothelial growth factor A	Homo sapiens	20-25
30229827-1	2018	OBJECTIVE: The aim of this study was to investigate the expression of micro ribonucleic acid-411-5P (miR-411-5p) in non-small cell lung cancer (NSCLC), and to explore the effect of miR-411-5p on the biological behavior of NSCLC cells as well as the underlying molecular mechanism.	CHEMBL3740941	109-111	microRNA 411	Homo sapiens	101-108
30004470-5	2018	Meanwhile, the levels of phosphorylated AKT were reduced by overexpression of miR-106a-5p, and administration of insulin-like growth factor 1 (IGF1), a booster of myogenic differentiation, could recover all the inhibitory effects above of miR-106a-5p.	CHEMBL3740941	87-89	AKT serine/threonine kinase 1	Homo sapiens	40-43
29916536-3	2018	In addition, overexpression of miR-590-5p significantly reduced the proliferation, migration and invasion of SAOS2 and U2OS cells in vitro, as well as inhibiting tumor sizes in vivo.	CHEMBL3740941	39-41	microRNA 590	Homo sapiens	31-38
30059491-8	2018	Collagen-induced arthritis (CIA) was induced by injecting DBA/1 mice with bovine type II collagen (CII), and miR-145-5p agomir was administered by intravenous injection.	CHEMBL3740941	117-119	microRNA 145	Bos taurus	109-116
30059491-13	2018	Micro-CT analysis of the arthritic joints showed that the miR-145-5p agomir caused bone erosion in mice, and histopathological analysis revealed that miR-145-5p agomir aggravates cartilage erosion.	CHEMBL3740941	66-68	microRNA 145a	Mus musculus	58-65
30171732-7	2018	Reduced levels of serum exosomal miR-548c-5p were more significant in CRC patients with liver metastasis and at later TNM stage (III/IV tumor stages).	CHEMBL3740941	42-44	microRNA 548c	Homo sapiens	33-41
30171732-7	2018	Reduced levels of serum exosomal miR-548c-5p were more significant in CRC patients with liver metastasis and at later TNM stage (III/IV tumor stages).	CHEMBL3740941	42-44	teneurin transmembrane protein 1	Homo sapiens	118-121
30140158-1	2018	Objective: The aim of this study was to investigate the prognostic value of mircoRNA-17 and mircoRNA-17-5P (miR-17/17-5P) in patients with cancer.	CHEMBL3740941	104-106	microRNA 17	Homo sapiens	108-114
30004470-5	2018	Meanwhile, the levels of phosphorylated AKT were reduced by overexpression of miR-106a-5p, and administration of insulin-like growth factor 1 (IGF1), a booster of myogenic differentiation, could recover all the inhibitory effects above of miR-106a-5p.	CHEMBL3740941	87-89	microRNA 615	Mus musculus	78-81
30004470-5	2018	Meanwhile, the levels of phosphorylated AKT were reduced by overexpression of miR-106a-5p, and administration of insulin-like growth factor 1 (IGF1), a booster of myogenic differentiation, could recover all the inhibitory effects above of miR-106a-5p.	CHEMBL3740941	87-89	insulin like growth factor 1	Homo sapiens	113-141
30004470-5	2018	Meanwhile, the levels of phosphorylated AKT were reduced by overexpression of miR-106a-5p, and administration of insulin-like growth factor 1 (IGF1), a booster of myogenic differentiation, could recover all the inhibitory effects above of miR-106a-5p.	CHEMBL3740941	87-89	insulin like growth factor 1	Homo sapiens	143-147
30004470-5	2018	Meanwhile, the levels of phosphorylated AKT were reduced by overexpression of miR-106a-5p, and administration of insulin-like growth factor 1 (IGF1), a booster of myogenic differentiation, could recover all the inhibitory effects above of miR-106a-5p.	CHEMBL3740941	87-89	microRNA 615	Mus musculus	239-242
29466052-5	2018	Inhibition of SNHG1 suppressed NSCLC cell viability, proliferation, migration, and invasion in vitro, but its effect was rescued by miR-145-5p inhibition.	CHEMBL3740941	140-142	small nucleolar RNA host gene 1	Homo sapiens	14-19
29897461-7	2018	miR-145-5p inhibitor and mimic transfections were performed to study downstream gene expression in human CCs.	CHEMBL3740941	8-10	microRNA 145	Homo sapiens	0-7
29191771-0	2018	Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.	CHEMBL3740941	22-24	microRNA 155	Rattus norvegicus	10-21
30108445-7	2018	miR-30b-5p expression was significantly lower in gliomas than the normal brain tissues.	CHEMBL3740941	8-10	microRNA 30b	Homo sapiens	0-7
29940895-8	2018	The validation cohort confirmed miR-29b-2-5p as an independent prognostic factor in PDAC (n = 100, 95% CI = 0.305-0.756, p = 0.002).	CHEMBL3740941	42-44	microRNA 29b-2	Homo sapiens	32-41
29191771-0	2018	Silencing rno-miR-155-5p in rat temporal lobe epilepsy model reduces pathophysiological features and cell apoptosis by activating Sestrin-3.	CHEMBL3740941	22-24	sestrin 3	Rattus norvegicus	130-139
29890825-8	2018	Furthermore, BRMS1 and miR-3200-5p levels were inversely correlated to each other.	CHEMBL3740941	32-34	microRNA 3200	Homo sapiens	23-31
29773756-3	2018	Here, we identified reduced levels of miR126-5p in presymptomatic ALS male mice models, and an increase in its targets: axon destabilizing Type 3 Semaphorins and their coreceptor Neuropilins.	CHEMBL3740941	45-47	microRNA 126a	Mus musculus	38-44
29773756-6	2018	We suggest a novel regulatory role for miR126-5p in ALS and demonstrate, for the first time, a mechanism by which alterations in miR126-5p contribute to axon degeneration and NMJ disruption observed in ALS.	CHEMBL3740941	46-48	microRNA 126a	Mus musculus	39-45
29773756-6	2018	We suggest a novel regulatory role for miR126-5p in ALS and demonstrate, for the first time, a mechanism by which alterations in miR126-5p contribute to axon degeneration and NMJ disruption observed in ALS.	CHEMBL3740941	136-138	microRNA 126a	Mus musculus	39-45
29773756-6	2018	We suggest a novel regulatory role for miR126-5p in ALS and demonstrate, for the first time, a mechanism by which alterations in miR126-5p contribute to axon degeneration and NMJ disruption observed in ALS.	CHEMBL3740941	136-138	microRNA 126a	Mus musculus	129-135
29549727-13	2018	Overall, our results show that miR-20b-5p impedes PDGF-induced proliferation of fetal ASM cells through targeting STAT3.	CHEMBL3740941	39-41	signal transducer and activator of transcription 3	Homo sapiens	114-119
29705350-9	2018	SIGNIFICANCE: Our results indicated that miRNA-150-5p might be involved in the antihypertensive effect of EGCG through SP1/AT1R pathway.	CHEMBL3740941	51-53	angiotensin II receptor, type 1a	Rattus norvegicus	123-127
29710538-6	2018	A luciferase reporter assay was performed to identify whether miR-338-5p targeted the 3"-UTR of CD82 mRNA.	CHEMBL3740941	70-72	CD82 molecule	Homo sapiens	96-100
29545315-4	2018	Human synovial sarcoma cell line, SW982 cells stimulating with interleukin-1beta (IL-1beta) were transfected with miR-10a-5p mimic and siRNA of TBX5.	CHEMBL3740941	122-124	microRNA 10a	Homo sapiens	114-121
29568969-13	2018	HPC upregulated miR-133b-5p level was markedly suppressed by the antagomir.	CHEMBL3740941	25-27	microRNA 133b	Rattus norvegicus	16-24
29545884-9	2018	The LRH-1/Wnt/beta-catenin signaling pathway was also inhibited by SCI, while it was significantly enhanced by the miR-219-5p inhibitor.	CHEMBL3740941	123-125	nuclear receptor subfamily 5, group A, member 2	Mus musculus	4-9
29650964-4	2018	Elevated TSPAN15 expression is, in part, caused by the reduction of miR-339-5p.	CHEMBL3740941	76-78	tetraspanin 15	Homo sapiens	9-16
29545884-9	2018	The LRH-1/Wnt/beta-catenin signaling pathway was also inhibited by SCI, while it was significantly enhanced by the miR-219-5p inhibitor.	CHEMBL3740941	123-125	microRNA 615	Mus musculus	115-118
29359963-9	2018	These results uncovered the anticancer effect of melatonin and highlighted the critical roles of miR-16-5p-Smad3 pathway in melatonin-induced growth defects of gastric cancers.	CHEMBL3740941	104-106	SMAD family member 3	Homo sapiens	107-112
30099442-13	2018	The restored ZBTB20 expression partially rescued the miR-758-5p-induced inhibition of GBM cell proliferation, migration, and invasion.	CHEMBL3740941	61-63	zinc finger and BTB domain containing 20	Homo sapiens	13-19
29286111-2	2018	Our previous study revealed an increase in miR-31a-5p levels in the failing hearts of a rat HF model.	CHEMBL3740941	51-53	microRNA 31	Rattus norvegicus	43-50
29527329-6	2018	These data indicate that the miR-338-5p/EGFR/ABCB1 regulatory loop plays a critical role in HCC, and a negative correlation between miR-338-5p and EGFR or ABCB1 was also detected in HCC clinical samples.	CHEMBL3740941	37-39	epidermal growth factor receptor	Homo sapiens	40-44
29527329-6	2018	These data indicate that the miR-338-5p/EGFR/ABCB1 regulatory loop plays a critical role in HCC, and a negative correlation between miR-338-5p and EGFR or ABCB1 was also detected in HCC clinical samples.	CHEMBL3740941	37-39	ATP binding cassette subfamily B member 1	Homo sapiens	45-50
29527329-6	2018	These data indicate that the miR-338-5p/EGFR/ABCB1 regulatory loop plays a critical role in HCC, and a negative correlation between miR-338-5p and EGFR or ABCB1 was also detected in HCC clinical samples.	CHEMBL3740941	37-39	epidermal growth factor receptor	Homo sapiens	147-151
29527329-6	2018	These data indicate that the miR-338-5p/EGFR/ABCB1 regulatory loop plays a critical role in HCC, and a negative correlation between miR-338-5p and EGFR or ABCB1 was also detected in HCC clinical samples.	CHEMBL3740941	37-39	ATP binding cassette subfamily B member 1	Homo sapiens	155-160
29229394-4	2018	The animal experiments showed that miR-628-5p decreased the tumourigenecity of EOC cells.	CHEMBL3740941	43-45	microRNA 628	Homo sapiens	35-42
29339076-11	2018	In conclusion, it may suggest that the suppression of miR-361-5p suppressed PASMC survival and migration by targeting ABCA1 and inhibiting the JAK2/STAT3 pathway.	CHEMBL3740941	62-64	microRNA 361	Homo sapiens	54-61
29339076-11	2018	In conclusion, it may suggest that the suppression of miR-361-5p suppressed PASMC survival and migration by targeting ABCA1 and inhibiting the JAK2/STAT3 pathway.	CHEMBL3740941	62-64	ATP binding cassette subfamily A member 1	Homo sapiens	118-123
29339076-11	2018	In conclusion, it may suggest that the suppression of miR-361-5p suppressed PASMC survival and migration by targeting ABCA1 and inhibiting the JAK2/STAT3 pathway.	CHEMBL3740941	62-64	Janus kinase 2	Homo sapiens	143-147
29339076-11	2018	In conclusion, it may suggest that the suppression of miR-361-5p suppressed PASMC survival and migration by targeting ABCA1 and inhibiting the JAK2/STAT3 pathway.	CHEMBL3740941	62-64	signal transducer and activator of transcription 3	Homo sapiens	148-153
29434944-12	2018	miR-196a-5p upregulation may predict delayed LNM.	CHEMBL3740941	9-11	MLX interacting protein	Homo sapiens	0-3
29223541-6	2018	Further studies suggested that LOC101927497 may function as a tumor suppressor by interacting with miR-574-5p.	CHEMBL3740941	107-109	CDK6 antisense RNA 1	Homo sapiens	31-43
30212824-13	2018	The circRNA-ACAP2 interaction regulated the expression of miR-21-5p, and miR-21-5p regulated the expression of Tiam1.	CHEMBL3740941	65-67	ArfGAP with coiled-coil, ankyrin repeat and PH domains 2	Homo sapiens	12-17
29437031-8	2018	CONCLUSION: miR-155 was highly overexpressed, yet it did not correlate with stages, while miR-486- 5p was extremely underexpressed and significantly correlated with stages of LC.	CHEMBL3740941	99-101	microRNA 486-1	Homo sapiens	90-97
28905994-4	2018	Here we found the expression of miR-324-5p was decreased in MM, especially in del(17p) MM.	CHEMBL3740941	40-42	microRNA 324	Homo sapiens	32-39
29115555-6	2018	miR-615-5p downregulation was significantly associated with advanced tumor-node-metastasis stage, positive lymph node metastasis and moderate-poor differentiation.	CHEMBL3740941	8-10	microRNA 615	Homo sapiens	0-7
29271995-9	2017	Furthermore, pyruvate dehydrogenase kinase 1 (PDK1) could be downregulated via overexpression of mir-138-5p, while PDK1 was upregulated via knockdown of mir-138-5p.	CHEMBL3740941	105-107	pyruvate dehydrogenase kinase 1	Homo sapiens	13-44
29270127-6	2017	Secondly, juveniles GIFT injected with miR-1338-5p antagomir were used to analyze the regulatory function of the miR-1338-5p-ghitm pair in vivo.	CHEMBL3740941	122-124	growth hormone-inducible transmembrane protein	Oreochromis niloticus	125-130
29225772-6	2017	The effect of GAS5 and miR-32-5p on PC progression was assessed with cell proliferation, migration, invasion and apoptosis in vitro.	CHEMBL3740941	30-32	microRNA 32	Homo sapiens	23-29
29271995-9	2017	Furthermore, pyruvate dehydrogenase kinase 1 (PDK1) could be downregulated via overexpression of mir-138-5p, while PDK1 was upregulated via knockdown of mir-138-5p.	CHEMBL3740941	105-107	pyruvate dehydrogenase kinase 1	Homo sapiens	46-50
28928081-5	2017	We found that miR-140-5p expression was markedly increased in mice kidney.	CHEMBL3740941	22-24	microRNA 140	Mus musculus	14-21
29039596-6	2017	Conversely, apoptosis was inhibited following transfection with a miR-99b-5p inhibitor.	CHEMBL3740941	74-76	microRNA 99b	Mus musculus	66-73
29164582-13	2017	miR-15a-5p overexpression restrained HEC-1-A cell proliferation and stemness.	CHEMBL3740941	8-10	NDC80 kinetochore complex component	Homo sapiens	37-42
29118673-7	2017	Results: We found that the miR-20a-5p level was higher in G-292 cells than in SJSA-1 cells.	CHEMBL3740941	35-37	microRNA 20a	Homo sapiens	27-34
29164582-16	2017	miR-15a-5p overexpression decreased Wnt3a protein expression.	CHEMBL3740941	8-10	Wnt family member 3A	Homo sapiens	36-41
29164582-17	2017	Wnt3a presented significant negative correlation with the miR-15a-5p level in endometrial cancer patients.	CHEMBL3740941	66-68	Wnt family member 3A	Homo sapiens	0-5
28714018-0	2017	miR-125a-5p upregulation suppresses the proliferation and induces the cell apoptosis of lung adenocarcinoma by targeting NEDD9.	CHEMBL3740941	9-11	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	121-126
28849105-4	2017	Furthermore, the targets of miR-145-5p were identified from the DEGs, and their potential functions and protein-protein interactions (PPIs) were analyzed.	CHEMBL3740941	36-38	microRNA 145	Homo sapiens	28-35
28840508-7	2017	Downregulation of VEGF-A, Bcl-2 and Notch1 proteins in thyroid carcinoma cells were noted in cells that transiently transfected with miR-34b-5p mimic.	CHEMBL3740941	141-143	vascular endothelial growth factor A	Homo sapiens	18-24
28840508-7	2017	Downregulation of VEGF-A, Bcl-2 and Notch1 proteins in thyroid carcinoma cells were noted in cells that transiently transfected with miR-34b-5p mimic.	CHEMBL3740941	141-143	BCL2 apoptosis regulator	Homo sapiens	26-31
28840508-7	2017	Downregulation of VEGF-A, Bcl-2 and Notch1 proteins in thyroid carcinoma cells were noted in cells that transiently transfected with miR-34b-5p mimic.	CHEMBL3740941	141-143	notch receptor 1	Homo sapiens	36-42
28840508-7	2017	Downregulation of VEGF-A, Bcl-2 and Notch1 proteins in thyroid carcinoma cells were noted in cells that transiently transfected with miR-34b-5p mimic.	CHEMBL3740941	141-143	microRNA 34b	Homo sapiens	133-140
28668331-5	2017	Tail intravenous injection of miR-34a-5p antagomir immediately after TAI exposure rescued TAI-mediated cognitive impairment via blocking the up-regulation of miR-34a-5p in PD, resulting in restoring the Bdnf expression in the hippocampus.	CHEMBL3740941	38-40	brain derived neurotrophic factor	Mus musculus	203-207
28627698-7	2017	The results of the present study identified that miR-508-5p functionally affects the SKP2 gene and reduces metastatic potential in GC, suggesting a novel role of miR-508-5p in the regulation of SKP2 and cell cycle.	CHEMBL3740941	57-59	microRNA 508	Homo sapiens	49-56
28627698-7	2017	The results of the present study identified that miR-508-5p functionally affects the SKP2 gene and reduces metastatic potential in GC, suggesting a novel role of miR-508-5p in the regulation of SKP2 and cell cycle.	CHEMBL3740941	57-59	S-phase kinase associated protein 2	Homo sapiens	85-89
28796037-3	2017	Subsequently, the expression level of miR-3144-5p in human cardiac myocytes (HCMs) was detected, followed by cell transfection with miR-3144-5p mimics.	CHEMBL3740941	47-49	membrane associated ring-CH-type finger 8	Homo sapiens	38-41
28647207-0	2017	Clinical value of miR-425-5p detection and its association with cell proliferation and apoptosis of gastric cancer.	CHEMBL3740941	26-28	microRNA 425	Homo sapiens	18-25
28627698-7	2017	The results of the present study identified that miR-508-5p functionally affects the SKP2 gene and reduces metastatic potential in GC, suggesting a novel role of miR-508-5p in the regulation of SKP2 and cell cycle.	CHEMBL3740941	57-59	microRNA 508	Homo sapiens	162-169
28627698-7	2017	The results of the present study identified that miR-508-5p functionally affects the SKP2 gene and reduces metastatic potential in GC, suggesting a novel role of miR-508-5p in the regulation of SKP2 and cell cycle.	CHEMBL3740941	57-59	S-phase kinase associated protein 2	Homo sapiens	194-198
29442023-0	2017	miR-122-5p inhibits tumor cell proliferation and induces apoptosis by targeting MYC in gastric cancer cells.	CHEMBL3740941	8-10	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	80-83
29137384-7	2017	Additionally, the function assay of miR-324-5p in PTC cells was conducted.	CHEMBL3740941	44-46	MLX interacting protein	Homo sapiens	36-39
28522550-11	2017	Inhibition of miR-135b-5p can protect against myocardial I/R injury by activating JAK2/STAT3 signaling pathway through mediation of inhalation anesthesia with sevoflurane.	CHEMBL3740941	23-25	Janus kinase 2	Mus musculus	82-86
28522550-11	2017	Inhibition of miR-135b-5p can protect against myocardial I/R injury by activating JAK2/STAT3 signaling pathway through mediation of inhalation anesthesia with sevoflurane.	CHEMBL3740941	23-25	signal transducer and activator of transcription 3	Mus musculus	87-92
28177765-2	2017	MicroRNA-17-5p (miR-17-5p) is hypothesized to act as a regulator of hepatic stellate cell (HSCs) activation by activation of the canonical Wnt-beta-catenin pathway.	CHEMBL3740941	12-14	catenin beta 1	Rattus norvegicus	143-155
28350117-8	2017	Apoptosis was markedly increased in the miR-205-5p siRNA cells compared with control cells.	CHEMBL3740941	48-50	microRNA 205	Homo sapiens	40-47
28580184-0	2017	A Fine-Tune Role of Mir-125a-5p on Foxn1 During Age-Associated Changes in the Thymus.	CHEMBL3740941	29-31	forkhead box N1	Mus musculus	35-40
28215748-11	2017	Moreover, miR-145-5p overexpression also reversed the effect of OGD on BV-2 cells activation.	CHEMBL3740941	18-20	microRNA 145a	Mus musculus	10-17
28423652-3	2017	We found that miR-29b-1-5p was downregulated in human TNBC tissues and cell lines.	CHEMBL3740941	24-26	microRNA 29b-1	Homo sapiens	14-23
28132399-9	2017	A xenograft tumor model was used to demonstrate that miR-155-5p targets PTEN and activates the PI3K/Akt pathway in vivo as well.	CHEMBL3740941	61-63	microRNA 155	Homo sapiens	53-60
28132399-9	2017	A xenograft tumor model was used to demonstrate that miR-155-5p targets PTEN and activates the PI3K/Akt pathway in vivo as well.	CHEMBL3740941	61-63	phosphatase and tensin homolog	Homo sapiens	72-76
28132399-9	2017	A xenograft tumor model was used to demonstrate that miR-155-5p targets PTEN and activates the PI3K/Akt pathway in vivo as well.	CHEMBL3740941	61-63	AKT serine/threonine kinase 1	Homo sapiens	100-103
28159509-8	2017	Mechanistically, (1) let-7b-5p is proangiogenic and inhibits its target gene, TGFBR1, in ECs; (2) PF exosomes transfer a functional let-7b-5p to ECs, thus reducing their TGFBR1 expression; and (3) let-7b-5p depletion in PF exosomes impairs the angiogenic response to these nanoparticles.	CHEMBL3740941	28-30	transforming growth factor beta receptor 1	Homo sapiens	78-84
28159509-8	2017	Mechanistically, (1) let-7b-5p is proangiogenic and inhibits its target gene, TGFBR1, in ECs; (2) PF exosomes transfer a functional let-7b-5p to ECs, thus reducing their TGFBR1 expression; and (3) let-7b-5p depletion in PF exosomes impairs the angiogenic response to these nanoparticles.	CHEMBL3740941	28-30	transforming growth factor beta receptor 1	Homo sapiens	170-176
28077323-7	2017	The functional relevance of miR-181a-5p-induced Egr1 decrease was supported by inhibition and overexpression of miR-181a-5p in HK-2 cells.	CHEMBL3740941	37-39	early growth response 1	Homo sapiens	48-52
28121353-2	2017	The aim of the present study was to determine the role of miR-508-5p in glioma.	CHEMBL3740941	66-68	microRNA 508	Homo sapiens	58-65
28535514-10	2017	Further studies suggested that miR-129-5p suppressed cell proliferation, migration and promoted apoptosis by inhibiting SOX4 and Wnt/beta-catenin pathway.	CHEMBL3740941	39-41	SRY-box transcription factor 4	Homo sapiens	120-124
28535514-10	2017	Further studies suggested that miR-129-5p suppressed cell proliferation, migration and promoted apoptosis by inhibiting SOX4 and Wnt/beta-catenin pathway.	CHEMBL3740941	39-41	catenin beta 1	Homo sapiens	133-145
28337887-7	2017	After transiently transfected with miR-888-5p mimic, our results demonstrated that miR-888-5p plays a major role in promoting the proliferation and metastatic potential of HCC cells.	CHEMBL3740941	43-45	microRNA 888	Homo sapiens	35-42
28852406-6	2017	Manipulation of individual microRNA levels demonstrated a direct effect of miR-125a-5p and miR-125b-5p on CYP11B2 and of miR-320a-3p levels on CYP11A1 and CYP17A1 mRNA.	CHEMBL3740941	84-86	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	143-150
28852406-6	2017	Manipulation of individual microRNA levels demonstrated a direct effect of miR-125a-5p and miR-125b-5p on CYP11B2 and of miR-320a-3p levels on CYP11A1 and CYP17A1 mRNA.	CHEMBL3740941	84-86	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	155-162
28852406-6	2017	Manipulation of individual microRNA levels demonstrated a direct effect of miR-125a-5p and miR-125b-5p on CYP11B2 and of miR-320a-3p levels on CYP11A1 and CYP17A1 mRNA.	CHEMBL3740941	100-102	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	106-113
28852406-6	2017	Manipulation of individual microRNA levels demonstrated a direct effect of miR-125a-5p and miR-125b-5p on CYP11B2 and of miR-320a-3p levels on CYP11A1 and CYP17A1 mRNA.	CHEMBL3740941	100-102	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	155-162
28337887-7	2017	After transiently transfected with miR-888-5p mimic, our results demonstrated that miR-888-5p plays a major role in promoting the proliferation and metastatic potential of HCC cells.	CHEMBL3740941	43-45	microRNA 888	Homo sapiens	83-90
27978829-9	2016	We identified 2 specific targeting sites for miR-138-5p in the 3" untranslated region (3"-UTR) of BIRC5.	CHEMBL3740941	53-55	baculoviral IAP repeat-containing 5	Mus musculus	98-103
27081863-0	2016	The downregulation of miR-125a-5p functions as a tumor suppressor by directly targeting MMP-11 in osteosarcoma.	CHEMBL3740941	31-33	MLX interacting protein	Homo sapiens	22-25
27662798-5	2016	In activated mouse HSCs, CCN2, alpha-smooth muscle actin, and collagen 1(alpha1) were suppressed by a miR-199a-5p mimic, whereas in quiescent mouse HSCs, the inhibited CCN2 3"-UTR activity was blocked by a miR-199a-5p antagomir.	CHEMBL3740941	111-113	cellular communication network factor 2	Mus musculus	25-29
27511210-5	2016	An MTT assay demonstrated that overexpression of miR-483-5p by transfection with miR-483-5p mimics significantly increased cell proliferation and Annexin V-propidium iodide staining indicated the suppression of cell apoptosis, suggesting that miR-483-5p has an important function in GCSC growth.	CHEMBL3740941	57-59	microRNA 483	Homo sapiens	49-56
27511210-5	2016	An MTT assay demonstrated that overexpression of miR-483-5p by transfection with miR-483-5p mimics significantly increased cell proliferation and Annexin V-propidium iodide staining indicated the suppression of cell apoptosis, suggesting that miR-483-5p has an important function in GCSC growth.	CHEMBL3740941	57-59	microRNA 483	Homo sapiens	81-88
27511210-5	2016	An MTT assay demonstrated that overexpression of miR-483-5p by transfection with miR-483-5p mimics significantly increased cell proliferation and Annexin V-propidium iodide staining indicated the suppression of cell apoptosis, suggesting that miR-483-5p has an important function in GCSC growth.	CHEMBL3740941	57-59	annexin A5	Homo sapiens	146-155
27511210-5	2016	An MTT assay demonstrated that overexpression of miR-483-5p by transfection with miR-483-5p mimics significantly increased cell proliferation and Annexin V-propidium iodide staining indicated the suppression of cell apoptosis, suggesting that miR-483-5p has an important function in GCSC growth.	CHEMBL3740941	57-59	microRNA 483	Homo sapiens	81-88
27003587-4	2016	However, the molecular function and mechanisms of miR-508-5p in gliomagenesis are still unclear.	CHEMBL3740941	58-60	microRNA 508	Homo sapiens	50-57
27420938-0	2016	SNP at miR-483-5p-binding site in the 3"-untranslated region of the BSG gene is associated with susceptibility to esophageal cancer in a Chinese population.	CHEMBL3740941	15-17	basigin (Ok blood group)	Homo sapiens	68-71
26935288-0	2016	miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.	CHEMBL3740941	8-10	sirtuin 1	Homo sapiens	142-147
27662798-5	2016	In activated mouse HSCs, CCN2, alpha-smooth muscle actin, and collagen 1(alpha1) were suppressed by a miR-199a-5p mimic, whereas in quiescent mouse HSCs, the inhibited CCN2 3"-UTR activity was blocked by a miR-199a-5p antagomir.	CHEMBL3740941	111-113	cellular communication network factor 2	Mus musculus	168-172
27499703-10	2016	One of miR-20a-5p"s targets, kinesin family member 26B (KIF26B), was found to mediate the miR-20a-5p-induced reduction in OS chemoresistance by modulating the activities of the MAPK/ERK and cAMP/PKA signaling pathways.	CHEMBL3740941	15-17	microRNA 20a	Homo sapiens	7-14
27499703-10	2016	One of miR-20a-5p"s targets, kinesin family member 26B (KIF26B), was found to mediate the miR-20a-5p-induced reduction in OS chemoresistance by modulating the activities of the MAPK/ERK and cAMP/PKA signaling pathways.	CHEMBL3740941	15-17	kinesin family member 26B	Homo sapiens	29-54
27499703-10	2016	One of miR-20a-5p"s targets, kinesin family member 26B (KIF26B), was found to mediate the miR-20a-5p-induced reduction in OS chemoresistance by modulating the activities of the MAPK/ERK and cAMP/PKA signaling pathways.	CHEMBL3740941	15-17	kinesin family member 26B	Homo sapiens	56-62
27499703-10	2016	One of miR-20a-5p"s targets, kinesin family member 26B (KIF26B), was found to mediate the miR-20a-5p-induced reduction in OS chemoresistance by modulating the activities of the MAPK/ERK and cAMP/PKA signaling pathways.	CHEMBL3740941	15-17	microRNA 20a	Homo sapiens	90-97
27081863-0	2016	The downregulation of miR-125a-5p functions as a tumor suppressor by directly targeting MMP-11 in osteosarcoma.	CHEMBL3740941	31-33	matrix metallopeptidase 11	Homo sapiens	88-94
27099602-10	2016	The expression levels of c-myc mRNA in cells transfected with miR-34a mimics were lower than that in cells transfected with the miR-34a-5p inhibitor, at 0.5 hours and 2 hours after transfection.	CHEMBL3740941	136-138	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	25-30
26864693-0	2016	Downregulation of miR-384-5p attenuates rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through inhibiting endoplasmic reticulum stress.	CHEMBL3740941	26-28	microRNA 384	Homo sapiens	18-25
26864693-13	2016	Moreover, we observed a significant increase of miR-384-5p expression in primary neurons induced by rotenone.	CHEMBL3740941	56-58	microRNA 384	Homo sapiens	48-55
27058413-5	2016	When HMEC are loaded with miR-145-5p mimics, the miR-145 level drastically increases in SW480.	CHEMBL3740941	34-36	microRNA 145	Homo sapiens	26-33
27058413-5	2016	When HMEC are loaded with miR-145-5p mimics, the miR-145 level drastically increases in SW480.	CHEMBL3740941	34-36	microRNA 145	Homo sapiens	49-56
27027434-4	2016	miR-26b- 5p downregulation was directly mediated by Twist1 through binding to the promoter region of miR-26b-5p in HepG2-Twist1 cells by ChIP-seq technology.	CHEMBL3740941	9-11	microRNA 26b	Mus musculus	0-7
27027434-4	2016	miR-26b- 5p downregulation was directly mediated by Twist1 through binding to the promoter region of miR-26b-5p in HepG2-Twist1 cells by ChIP-seq technology.	CHEMBL3740941	9-11	twist basic helix-loop-helix transcription factor 1	Mus musculus	52-58
27027434-4	2016	miR-26b- 5p downregulation was directly mediated by Twist1 through binding to the promoter region of miR-26b-5p in HepG2-Twist1 cells by ChIP-seq technology.	CHEMBL3740941	9-11	microRNA 26b	Mus musculus	101-108
27027434-4	2016	miR-26b- 5p downregulation was directly mediated by Twist1 through binding to the promoter region of miR-26b-5p in HepG2-Twist1 cells by ChIP-seq technology.	CHEMBL3740941	9-11	twist basic helix-loop-helix transcription factor 1	Mus musculus	121-127
27099602-10	2016	The expression levels of c-myc mRNA in cells transfected with miR-34a mimics were lower than that in cells transfected with the miR-34a-5p inhibitor, at 0.5 hours and 2 hours after transfection.	CHEMBL3740941	136-138	microRNA 34a	Homo sapiens	62-69
27099602-10	2016	The expression levels of c-myc mRNA in cells transfected with miR-34a mimics were lower than that in cells transfected with the miR-34a-5p inhibitor, at 0.5 hours and 2 hours after transfection.	CHEMBL3740941	136-138	microRNA 34a	Homo sapiens	128-135
26633713-5	2015	Mtfr1 is a direct target of miR-324-5p, and miR-324-5p attenuates mitochondrial fission, cardiomyocyte apoptosis and myocardial infarction by suppressing Mtfr1 translation.	CHEMBL3740941	36-38	mitochondrial fission regulator 1	Homo sapiens	0-5
27158352-0	2016	Macrophage autophagy regulated by miR-384-5p-mediated control of Beclin-1 plays a role in the development of atherosclerosis.	CHEMBL3740941	42-44	microRNA 384	Mus musculus	34-41
27158352-0	2016	Macrophage autophagy regulated by miR-384-5p-mediated control of Beclin-1 plays a role in the development of atherosclerosis.	CHEMBL3740941	42-44	beclin 1, autophagy related	Mus musculus	65-73
26473405-7	2016	In mice with CIA and mice with CAIA, the LV-mediated IA transfer of miR-140-3p and miR-140-5p ameliorated arthritis, as determined by clinical examination and histopathologic evaluations showing a decrease in SF densities.	CHEMBL3740941	91-93	microRNA 140	Mus musculus	83-90
26934326-5	2016	Inactivation of NF-kappaB by pyrrolidine dithiocarbamic acid (PDTC) significantly blocked the effect of miR-155-5p inhibitor on BM-MSC.	CHEMBL3740941	112-114	microRNA 155	Homo sapiens	104-111
26891291-6	2016	miR-9-5p and miR-675-5p induced MC3T3-E1 cell apoptosis more specifically than miR-138-5p.	CHEMBL3740941	21-23	microRNA 675	Mus musculus	13-20
26603571-9	2016	In addition, the upregulation of MCP-1 expression through miR-125b-5p inhibitors was attenuate by siRNA-LACTB treatment in LPS-stimulated THP-1 macrophages.	CHEMBL3740941	67-69	C-C motif chemokine ligand 2	Homo sapiens	33-38
26603571-9	2016	In addition, the upregulation of MCP-1 expression through miR-125b-5p inhibitors was attenuate by siRNA-LACTB treatment in LPS-stimulated THP-1 macrophages.	CHEMBL3740941	67-69	GLI family zinc finger 2	Homo sapiens	138-143
26623719-11	2016	Restoring the miR-27b and miR-508-5p levels might contribute to MDR reversion in future clinical practice.	CHEMBL3740941	34-36	microRNA 508	Homo sapiens	26-33
26633713-5	2015	Mtfr1 is a direct target of miR-324-5p, and miR-324-5p attenuates mitochondrial fission, cardiomyocyte apoptosis and myocardial infarction by suppressing Mtfr1 translation.	CHEMBL3740941	36-38	microRNA 324	Homo sapiens	28-35
26633713-5	2015	Mtfr1 is a direct target of miR-324-5p, and miR-324-5p attenuates mitochondrial fission, cardiomyocyte apoptosis and myocardial infarction by suppressing Mtfr1 translation.	CHEMBL3740941	36-38	mitochondrial fission regulator 1	Homo sapiens	154-159
26175215-8	2015	We are also able to confirm previous experimentally identified targets but, additionally, identify a novel positive regulation of the Wnt signaling pathway by miR-140-5p.	CHEMBL3740941	167-169	microRNA 140	Homo sapiens	159-166
26562412-8	2015	Although there was no difference in miR-423-5p levels among the PF-AS, PF-sAP, and PF-uAP, its levels were significantly elevated in S-uAP compared with those in S-AS and S-sAP.	CHEMBL3740941	44-46	microRNA 423	Homo sapiens	36-43
26255203-0	2015	MiR-30a-5p is induced by Wnt/beta-catenin pathway and promotes glioma cell invasion by repressing NCAM.	CHEMBL3740941	8-10	microRNA 30a	Homo sapiens	0-7
25990668-11	2015	CONCLUSIONS: The CC genotype of CDKN2B rs1063192 in the hsa-miR-323b-5p binding site increased the risk of GDM in pregnant Chinese Han women.	CHEMBL3740941	69-71	cyclin dependent kinase inhibitor 2B	Homo sapiens	32-38
25990668-11	2015	CONCLUSIONS: The CC genotype of CDKN2B rs1063192 in the hsa-miR-323b-5p binding site increased the risk of GDM in pregnant Chinese Han women.	CHEMBL3740941	69-71	myosin regulatory light chain interacting protein	Homo sapiens	60-63
26255203-0	2015	MiR-30a-5p is induced by Wnt/beta-catenin pathway and promotes glioma cell invasion by repressing NCAM.	CHEMBL3740941	8-10	catenin beta 1	Homo sapiens	29-41
26255203-0	2015	MiR-30a-5p is induced by Wnt/beta-catenin pathway and promotes glioma cell invasion by repressing NCAM.	CHEMBL3740941	8-10	neural cell adhesion molecule 1	Homo sapiens	98-102
26054676-10	2015	Our study for the first time demonstrated that miR-485-5p represses HCC invasive and metastatic capacities by targeting EMMPRIN expression.	CHEMBL3740941	55-57	microRNA 485	Homo sapiens	47-54
25931475-4	2015	In logistic analysis, controlling for HbA1c and other covariates, let-7c-5p and miR-29a-3p were associated with more than a 50% reduction in the risk of rapid progression (P &lt;= 0.001), while let-7b-5p and miR-21-5p were associated with a &gt;2.5-fold increase in the risk of ESRD (P &lt;= 0.005).	CHEMBL3740941	73-75	microRNA 215	Homo sapiens	208-217
26261542-12	2015	MiR-188-5p expression is correlated to the activation state of RASF and inhibits migration of these cells.	CHEMBL3740941	8-10	microRNA 188	Homo sapiens	0-7
26054676-10	2015	Our study for the first time demonstrated that miR-485-5p represses HCC invasive and metastatic capacities by targeting EMMPRIN expression.	CHEMBL3740941	55-57	basigin (Ok blood group)	Homo sapiens	120-127
26191188-12	2015	MiR-188-5p expression is correlated to the activation state of RASF and inhibits migration of these cells.	CHEMBL3740941	8-10	microRNA 188	Homo sapiens	0-7
25837765-7	2015	Additionally, the ambulatory 24-hour and daytime systolic and diastolic blood pressures were negatively correlated with miR-296-5p.	CHEMBL3740941	128-130	microRNA 296	Homo sapiens	120-127
25379760-8	2014	In addition, transfection with a miR-181a-5p inhibitor in PLC/PRF/5 hepatic cells increased both the levels of F11 mRNA and extracellular FXI.	CHEMBL3740941	42-44	heparan sulfate proteoglycan 2	Homo sapiens	58-61
25714014-7	2015	In addition, transfection of miR-106b-5p antagomir resulted in the increased binding of H3K36me3 to the promoter of p53 and enhanced its activity, as well as upregulated the mRNA and protein levels of p53, and the effects were also abolished by cotransfection with si-SETD2.	CHEMBL3740941	38-40	microRNA 106b	Homo sapiens	29-37
25714014-7	2015	In addition, transfection of miR-106b-5p antagomir resulted in the increased binding of H3K36me3 to the promoter of p53 and enhanced its activity, as well as upregulated the mRNA and protein levels of p53, and the effects were also abolished by cotransfection with si-SETD2.	CHEMBL3740941	38-40	tumor protein p53	Homo sapiens	116-119
25714014-7	2015	In addition, transfection of miR-106b-5p antagomir resulted in the increased binding of H3K36me3 to the promoter of p53 and enhanced its activity, as well as upregulated the mRNA and protein levels of p53, and the effects were also abolished by cotransfection with si-SETD2.	CHEMBL3740941	38-40	tumor protein p53	Homo sapiens	201-204
25714014-7	2015	In addition, transfection of miR-106b-5p antagomir resulted in the increased binding of H3K36me3 to the promoter of p53 and enhanced its activity, as well as upregulated the mRNA and protein levels of p53, and the effects were also abolished by cotransfection with si-SETD2.	CHEMBL3740941	38-40	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	268-273
25379760-8	2014	In addition, transfection with a miR-181a-5p inhibitor in PLC/PRF/5 hepatic cells increased both the levels of F11 mRNA and extracellular FXI.	CHEMBL3740941	42-44	coagulation factor XI	Homo sapiens	138-141
25104088-7	2014	Together, we conclude that miR-486-5p exerts its antiproliferative function by directly downregulating PIM-1 expression.	CHEMBL3740941	35-37	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	103-108
25210621-13	2014	In contradiction to these observations, it is presumed that miR-10b-5p upregulation in HD exerts a neuroprotective role in response to the mutation in the huntingtin gene.	CHEMBL3740941	68-70	microRNA 10b	Homo sapiens	60-67
24913034-12	2014	Overexpression of miR-30b-5p inhibited cell migration.	CHEMBL3740941	26-28	microRNA 30b	Homo sapiens	18-25
25210621-13	2014	In contradiction to these observations, it is presumed that miR-10b-5p upregulation in HD exerts a neuroprotective role in response to the mutation in the huntingtin gene.	CHEMBL3740941	68-70	huntingtin	Homo sapiens	155-165
24789343-3	2014	The present study was designed to identify whether miR-376b-5p is involved in angiogenesis following cerebral ischemia and to elucidate the underlying mechanisms.	CHEMBL3740941	60-62	microRNA 376b	Homo sapiens	51-59
25124290-14	2014	MiR-671-5p inhibitor transfection into OFSCs selectively enhanced the IL-1 RA and sTNF RII expressions.	CHEMBL3740941	8-10	microRNA 671	Mus musculus	0-7
25124290-14	2014	MiR-671-5p inhibitor transfection into OFSCs selectively enhanced the IL-1 RA and sTNF RII expressions.	CHEMBL3740941	8-10	interleukin 1 receptor antagonist	Mus musculus	70-77
24789343-6	2014	The miR-376b-5p mimic or the miR-376b-5p inhibitor were transfected into hypoxic human umbilical vein endothelial cells (HUVECs), and the proliferation, migration and tube formation were measured.	CHEMBL3740941	13-15	microRNA 376b	Homo sapiens	4-12
23618359-10	2013	MiR-125a-5p/125b can be considered among the therapeutic targets in HER2-positive esophageal and gastric adenocarcinoma.	CHEMBL3740941	9-11	erb-b2 receptor tyrosine kinase 2	Homo sapiens	68-72
24710410-4	2014	Mechanistically, miR-483-5p is activated by the WNT/beta-catenin signaling pathway and exerts its prometastatic function by directly targeting the Rho GDP dissociation inhibitor alpha (RhoGDI1) and activated leukocyte cell adhesion molecule (ALCAM), two putative metastasis suppressors.	CHEMBL3740941	25-27	microRNA 483	Homo sapiens	17-24
24710410-4	2014	Mechanistically, miR-483-5p is activated by the WNT/beta-catenin signaling pathway and exerts its prometastatic function by directly targeting the Rho GDP dissociation inhibitor alpha (RhoGDI1) and activated leukocyte cell adhesion molecule (ALCAM), two putative metastasis suppressors.	CHEMBL3740941	25-27	catenin beta 1	Homo sapiens	52-64
24710410-4	2014	Mechanistically, miR-483-5p is activated by the WNT/beta-catenin signaling pathway and exerts its prometastatic function by directly targeting the Rho GDP dissociation inhibitor alpha (RhoGDI1) and activated leukocyte cell adhesion molecule (ALCAM), two putative metastasis suppressors.	CHEMBL3740941	25-27	Rho GDP dissociation inhibitor alpha	Homo sapiens	147-183
24710410-4	2014	Mechanistically, miR-483-5p is activated by the WNT/beta-catenin signaling pathway and exerts its prometastatic function by directly targeting the Rho GDP dissociation inhibitor alpha (RhoGDI1) and activated leukocyte cell adhesion molecule (ALCAM), two putative metastasis suppressors.	CHEMBL3740941	25-27	Rho GDP dissociation inhibitor alpha	Homo sapiens	185-192
24710410-4	2014	Mechanistically, miR-483-5p is activated by the WNT/beta-catenin signaling pathway and exerts its prometastatic function by directly targeting the Rho GDP dissociation inhibitor alpha (RhoGDI1) and activated leukocyte cell adhesion molecule (ALCAM), two putative metastasis suppressors.	CHEMBL3740941	25-27	activated leukocyte cell adhesion molecule	Homo sapiens	242-247
24641359-0	2014	MiR-886-5p inhibition inhibits growth and induces apoptosis of MCF7 cells.	CHEMBL3740941	8-10	membrane associated ring-CH-type finger 8	Homo sapiens	0-3
23752207-6	2013	Examination of the individual effects of miR-142-5p and miR-142-3p through overexpression and inhibition studies revealed that significant effects on SIRT1 occurred only with miR-142-5p.	CHEMBL3740941	49-51	microRNA 142	Homo sapiens	41-48
23752207-6	2013	Examination of the individual effects of miR-142-5p and miR-142-3p through overexpression and inhibition studies revealed that significant effects on SIRT1 occurred only with miR-142-5p.	CHEMBL3740941	49-51	sirtuin 1	Homo sapiens	150-155
24204837-5	2013	Here, we report that miR-1207-5p, a PVT1-derived microRNA, is abundantly expressed in kidney cells, and is upregulated by glucose and TGF-beta1.	CHEMBL3740941	30-32	Pvt1 oncogene	Homo sapiens	36-40
24204837-5	2013	Here, we report that miR-1207-5p, a PVT1-derived microRNA, is abundantly expressed in kidney cells, and is upregulated by glucose and TGF-beta1.	CHEMBL3740941	30-32	transforming growth factor beta 1	Homo sapiens	134-143
24015284-4	2013	miR-33a, specifically miR-33a-5p, was demonstrated to down-regulate the expression of beta-catenin, affect the beta-catenin pathway, and inhibit cell growth.	CHEMBL3740941	30-32	microRNA 33a	Homo sapiens	0-7
24015284-4	2013	miR-33a, specifically miR-33a-5p, was demonstrated to down-regulate the expression of beta-catenin, affect the beta-catenin pathway, and inhibit cell growth.	CHEMBL3740941	30-32	microRNA 33a	Homo sapiens	22-29
24015284-4	2013	miR-33a, specifically miR-33a-5p, was demonstrated to down-regulate the expression of beta-catenin, affect the beta-catenin pathway, and inhibit cell growth.	CHEMBL3740941	30-32	catenin beta 1	Homo sapiens	86-98
24015284-4	2013	miR-33a, specifically miR-33a-5p, was demonstrated to down-regulate the expression of beta-catenin, affect the beta-catenin pathway, and inhibit cell growth.	CHEMBL3740941	30-32	catenin beta 1	Homo sapiens	111-123
22322911-2	2012	We previously reported the tumor suppressive effect of miR-125a-5p in gastric cancer.	CHEMBL3740941	64-66	membrane associated ring-CH-type finger 8	Homo sapiens	55-58
24616567-13	2013	However, miR-143-5p alone directly targets COX-2, and it exhibits a stronger tumor suppressive effect than miR-143-3p.	CHEMBL3740941	17-19	microRNA 143	Homo sapiens	9-16
24616567-13	2013	However, miR-143-5p alone directly targets COX-2, and it exhibits a stronger tumor suppressive effect than miR-143-3p.	CHEMBL3740941	17-19	prostaglandin-endoperoxide synthase 2	Homo sapiens	43-48
23015294-11	2012	miR883b-5p blockade also abolished the protective effects of ApN on proinflammatory adipokine induction.	CHEMBL3740941	8-10	microRNA 883b	Mus musculus	0-7
22465663-6	2012	ERK1 knockdown can block cell proliferation induced by miR-483-5p inhibition.	CHEMBL3740941	63-65	mitogen-activated protein kinase 3	Homo sapiens	0-4
22465663-6	2012	ERK1 knockdown can block cell proliferation induced by miR-483-5p inhibition.	CHEMBL3740941	63-65	microRNA 483	Homo sapiens	55-62
23315007-8	2013	In addition, the PIK3CD protein level in H9c2 cells was up-regulated by miR-384-5p inhibitor.	CHEMBL3740941	80-82	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	Rattus norvegicus	17-23
23315007-8	2013	In addition, the PIK3CD protein level in H9c2 cells was up-regulated by miR-384-5p inhibitor.	CHEMBL3740941	80-82	microRNA 384	Rattus norvegicus	72-79
23249749-8	2013	We highlight targets that could be responsible for miR-182-5p-mediated disruption of other biological processes attributed in the literature so far.	CHEMBL3740941	59-61	microRNA 182	Homo sapiens	51-58
23015294-11	2012	miR883b-5p blockade also abolished the protective effects of ApN on proinflammatory adipokine induction.	CHEMBL3740941	8-10	adiponectin, C1Q and collagen domain containing	Mus musculus	61-64
25059272-0	2014	miR-125a-5p impairs endothelial cell angiogenesis in aging mice via RTEF-1 downregulation.	CHEMBL3740941	9-11	TEA domain family member 4	Mus musculus	68-74
22197249-8	2012	Moreover, RNA and protein biosynthesis in wild-type CVB3 was significantly inhibited by miR-342-5p.	CHEMBL3740941	96-98	microRNA 342	Mus musculus	88-95
20799954-14	2010	However, the effect of miR-199a-5p on DDR1 varies among individuals and hepatoma cell lines.	CHEMBL3740941	32-34	discoidin domain receptor tyrosine kinase 1	Homo sapiens	38-42
33590038-7	2021	MiR-744-5p bound to MNX1-AS1.	CHEMBL3740941	8-10	microRNA 744	Homo sapiens	0-7
33590038-7	2021	MiR-744-5p bound to MNX1-AS1.	CHEMBL3740941	8-10	motor neuron and pancreas homeobox 1	Homo sapiens	20-24
33590038-7	2021	MiR-744-5p bound to MNX1-AS1.	CHEMBL3740941	8-10	prostaglandin D2 receptor	Homo sapiens	25-28
20723344-8	2009	The invasive ability of A549 cells transfected with sense hsa-miR-125a-5p 2"-O-methyl oligonucleotide were weakened after being blocked by anti-Rock-1, vs non-blocking group by Transwell test.	CHEMBL3740941	71-73	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	144-150
33235467-9	2020	On the other hand, it is further confirmed that PLK1 was a target gene of miR-1224-5p.	CHEMBL3740941	83-85	polo like kinase 1	Homo sapiens	48-52
33235467-9	2020	On the other hand, it is further confirmed that PLK1 was a target gene of miR-1224-5p.	CHEMBL3740941	83-85	microRNA 1224	Homo sapiens	74-82
34944037-10	2021	Treatment with miR-497-5p inhibitors did not change the diameter of the myotubes but increased the expression of its target genes Insr and Igf1r.	CHEMBL3740941	23-25	microRNA 497	Homo sapiens	15-22
34817752-12	2022	Moreover, rescue assays reveal that miR-1277-5p overexpression (or ACER3 overexpression) reversed the effects of LINC01087 upregulation (or miR-1277-5p upregulation) on glioma cells.	CHEMBL3740941	45-47	long intergenic non-protein coding RNA 1087	Homo sapiens	113-122
34817752-12	2022	Moreover, rescue assays reveal that miR-1277-5p overexpression (or ACER3 overexpression) reversed the effects of LINC01087 upregulation (or miR-1277-5p upregulation) on glioma cells.	CHEMBL3740941	45-47	microRNA 1277	Homo sapiens	140-148
34930906-11	2021	Intratumoral injection of miR-541-5p inhibitor suppressed tumor growth and reversed the effect of circMTO1 silencing on the promotion of tumor growth in HCC.	CHEMBL3740941	34-36	microRNA 541	Homo sapiens	26-33
34930906-11	2021	Intratumoral injection of miR-541-5p inhibitor suppressed tumor growth and reversed the effect of circMTO1 silencing on the promotion of tumor growth in HCC.	CHEMBL3740941	34-36	mitochondrial tRNA translation optimization 1	Homo sapiens	98-106
34944037-10	2021	Treatment with miR-497-5p inhibitors did not change the diameter of the myotubes but increased the expression of its target genes Insr and Igf1r.	CHEMBL3740941	23-25	insulin receptor	Homo sapiens	130-134
34944037-10	2021	Treatment with miR-497-5p inhibitors did not change the diameter of the myotubes but increased the expression of its target genes Insr and Igf1r.	CHEMBL3740941	23-25	insulin like growth factor 1 receptor	Homo sapiens	139-144
34592879-13	2021	Finally, we demonstrated that HC0074027 can indirectly modulate IGF1 levels via sequestering miR-379-5p.	CHEMBL3740941	101-103	insulin-like growth factor 1	Mus musculus	64-68
34315248-6	2021	The apoptosis and autophagy, and related proteins were detected in chondrocytes treated with miR-146a-5p mimic/inhibitor or pcDNA3.1-NUMB/si-NUMB and IL-1beta, respectively.	CHEMBL3740941	102-104	microRNA 146a	Homo sapiens	93-101
34338955-9	2021	MIR3142HG impaired miR-450b-5p-mediated inhibition of HMGB1.	CHEMBL3740941	28-30	MIR3142 host gene	Homo sapiens	0-9
34596006-14	2021	All in all, this study corroborates that DARS-AS1 facilitates HCC proliferation and metastasis by regulating miR-3200-5p-mediated CKAP2, which provides a potential target for HCC diagnosis and treatment.	CHEMBL3740941	118-120	DARS1 antisense RNA 1	Homo sapiens	41-49
34596006-14	2021	All in all, this study corroborates that DARS-AS1 facilitates HCC proliferation and metastasis by regulating miR-3200-5p-mediated CKAP2, which provides a potential target for HCC diagnosis and treatment.	CHEMBL3740941	118-120	microRNA 3200	Homo sapiens	109-117
34596006-14	2021	All in all, this study corroborates that DARS-AS1 facilitates HCC proliferation and metastasis by regulating miR-3200-5p-mediated CKAP2, which provides a potential target for HCC diagnosis and treatment.	CHEMBL3740941	118-120	cytoskeleton associated protein 2	Homo sapiens	130-135
34338955-9	2021	MIR3142HG impaired miR-450b-5p-mediated inhibition of HMGB1.	CHEMBL3740941	28-30	high mobility group box 1	Homo sapiens	54-59
34181233-0	2021	Isoflurane Alleviates Myocardial Injury Induced by Hypoxia/Reoxygenation by Regulating miR-18a-5p.	CHEMBL3740941	95-97	microRNA 18a	Homo sapiens	87-94
34643044-9	2021	Fibrotic marker MMP9, TGFB1 and COL1A1 were significantly downregulated, while TIMP4 was significantly upregulated (at both mRNA and protein levels) by miR-146b-5p inhibition in cardiomyocytes of MI heart.	CHEMBL3740941	161-163	matrix metallopeptidase 9	Mus musculus	16-20
34643044-9	2021	Fibrotic marker MMP9, TGFB1 and COL1A1 were significantly downregulated, while TIMP4 was significantly upregulated (at both mRNA and protein levels) by miR-146b-5p inhibition in cardiomyocytes of MI heart.	CHEMBL3740941	161-163	transforming growth factor, beta 1	Mus musculus	22-27
34643044-9	2021	Fibrotic marker MMP9, TGFB1 and COL1A1 were significantly downregulated, while TIMP4 was significantly upregulated (at both mRNA and protein levels) by miR-146b-5p inhibition in cardiomyocytes of MI heart.	CHEMBL3740941	161-163	collagen, type I, alpha 1	Mus musculus	32-38
34643044-9	2021	Fibrotic marker MMP9, TGFB1 and COL1A1 were significantly downregulated, while TIMP4 was significantly upregulated (at both mRNA and protein levels) by miR-146b-5p inhibition in cardiomyocytes of MI heart.	CHEMBL3740941	161-163	tissue inhibitor of metalloproteinase 4	Mus musculus	79-84
34768749-4	2021	Ectopic miR-541-5p expression suppressed radiation-induced-EMT in vitro and in vivo.	CHEMBL3740941	16-18	microRNA 541	Mus musculus	8-15
34631548-0	2021	Bortezomib Inhibits Multiple Myeloma Cells by Transactivating ATF3 to Trigger miR-135a-5p- Dependent Apoptosis.	CHEMBL3740941	87-89	activating transcription factor 3	Homo sapiens	62-66
34236115-7	2021	Furthermore, miR-224-5p inhibitor-transfected amoeboid-like CD44high OSCC cells exhibited significant enhancement of the proportion of apoptotic cells; however, this effect was significantly inhibited by knockdown of PANX1 with PANX1 small interfering RNA.	CHEMBL3740941	21-23	microRNA 224	Homo sapiens	13-20
34236115-7	2021	Furthermore, miR-224-5p inhibitor-transfected amoeboid-like CD44high OSCC cells exhibited significant enhancement of the proportion of apoptotic cells; however, this effect was significantly inhibited by knockdown of PANX1 with PANX1 small interfering RNA.	CHEMBL3740941	21-23	CD44 molecule (Indian blood group)	Homo sapiens	60-64
34236115-7	2021	Furthermore, miR-224-5p inhibitor-transfected amoeboid-like CD44high OSCC cells exhibited significant enhancement of the proportion of apoptotic cells; however, this effect was significantly inhibited by knockdown of PANX1 with PANX1 small interfering RNA.	CHEMBL3740941	21-23	pannexin 1	Homo sapiens	217-222
34236115-7	2021	Furthermore, miR-224-5p inhibitor-transfected amoeboid-like CD44high OSCC cells exhibited significant enhancement of the proportion of apoptotic cells; however, this effect was significantly inhibited by knockdown of PANX1 with PANX1 small interfering RNA.	CHEMBL3740941	21-23	pannexin 1	Homo sapiens	228-233
34650682-20	2021	Oe-CALB1 partially reversed the effect on the miR-34b-5p mimic group.	CHEMBL3740941	54-56	calbindin 1	Rattus norvegicus	3-8
34589382-10	2021	MiR-1287-5p inhibition accentuated OGD/R-induced oxidative damage in SH-SY5Y cells, which was reversed by Cur.	CHEMBL3740941	9-11	microRNA 1287	Homo sapiens	0-8
34589382-11	2021	The expression of LONP2 in OGD/R-treated SH-SY5Y cells was decreased by miR-1287-5p overexpression and increased by miR-1287-5p inhibition, and Cur counteracted the increase in LONP2 expression induced by miR-1287-5p inhibition.	CHEMBL3740941	81-83	lon peptidase 2, peroxisomal	Homo sapiens	18-23
34589382-11	2021	The expression of LONP2 in OGD/R-treated SH-SY5Y cells was decreased by miR-1287-5p overexpression and increased by miR-1287-5p inhibition, and Cur counteracted the increase in LONP2 expression induced by miR-1287-5p inhibition.	CHEMBL3740941	125-127	lon peptidase 2, peroxisomal	Homo sapiens	18-23
34589382-11	2021	The expression of LONP2 in OGD/R-treated SH-SY5Y cells was decreased by miR-1287-5p overexpression and increased by miR-1287-5p inhibition, and Cur counteracted the increase in LONP2 expression induced by miR-1287-5p inhibition.	CHEMBL3740941	125-127	microRNA 1287	Homo sapiens	116-124
34589382-11	2021	The expression of LONP2 in OGD/R-treated SH-SY5Y cells was decreased by miR-1287-5p overexpression and increased by miR-1287-5p inhibition, and Cur counteracted the increase in LONP2 expression induced by miR-1287-5p inhibition.	CHEMBL3740941	214-216	lon peptidase 2, peroxisomal	Homo sapiens	18-23
34589382-11	2021	The expression of LONP2 in OGD/R-treated SH-SY5Y cells was decreased by miR-1287-5p overexpression and increased by miR-1287-5p inhibition, and Cur counteracted the increase in LONP2 expression induced by miR-1287-5p inhibition.	CHEMBL3740941	214-216	microRNA 1287	Homo sapiens	205-213
34522457-0	2021	MiR-374b-5p inhibits KDM5B-induced epithelial-mesenchymal transition in pancreatic cancer.	CHEMBL3740941	9-11	microRNA 374b	Homo sapiens	0-8
34228324-13	2021	Rescue experiments indicated that the inhibitory effect of circ_0069244 was abolished by co-expression of miR-346-5p mimics.	CHEMBL3740941	114-116	microRNA 346	Homo sapiens	106-113
34659819-10	2021	In the KYSE-150 cells, the colony formation assay and flow cytometry analysis indicated that the miR-488-5p inhibitor inhibited cell viability and increased cell apoptosis; however, these effects were recovered by P53 knockdown (KD).	CHEMBL3740941	105-107	microRNA 488	Homo sapiens	97-104
34659819-12	2021	Similarly, the miR-488-5p inhibitor induced the expression of P53 and P21 than normal control (NC) group in which miR-488-5p expression was normal, while P53 KD prevented the effects of the miR-488-5p inhibitor in KYSE-150 cells.	CHEMBL3740941	198-200	H3 histone pseudogene 16	Homo sapiens	70-73
34659819-12	2021	Similarly, the miR-488-5p inhibitor induced the expression of P53 and P21 than normal control (NC) group in which miR-488-5p expression was normal, while P53 KD prevented the effects of the miR-488-5p inhibitor in KYSE-150 cells.	CHEMBL3740941	198-200	tumor protein p53	Homo sapiens	154-157
34481934-7	2021	Mechanistically, miR-769-5p/miR-769-3p targeted IGF1R and IGF1R overexpression rescued the effects of miR-769-5p/miR-769-3p on GC cells growth and metastasis.	CHEMBL3740941	110-112	microRNA 769	Homo sapiens	17-24
34481934-7	2021	Mechanistically, miR-769-5p/miR-769-3p targeted IGF1R and IGF1R overexpression rescued the effects of miR-769-5p/miR-769-3p on GC cells growth and metastasis.	CHEMBL3740941	110-112	insulin like growth factor 1 receptor	Homo sapiens	48-53
34481934-7	2021	Mechanistically, miR-769-5p/miR-769-3p targeted IGF1R and IGF1R overexpression rescued the effects of miR-769-5p/miR-769-3p on GC cells growth and metastasis.	CHEMBL3740941	110-112	insulin like growth factor 1 receptor	Homo sapiens	58-63
34481934-7	2021	Mechanistically, miR-769-5p/miR-769-3p targeted IGF1R and IGF1R overexpression rescued the effects of miR-769-5p/miR-769-3p on GC cells growth and metastasis.	CHEMBL3740941	110-112	microRNA 769	Homo sapiens	102-109
34481934-7	2021	Mechanistically, miR-769-5p/miR-769-3p targeted IGF1R and IGF1R overexpression rescued the effects of miR-769-5p/miR-769-3p on GC cells growth and metastasis.	CHEMBL3740941	110-112	microRNA 769	Homo sapiens	113-120
34386082-9	2021	The target relationship between miR-1298-5p and E2F1 was validated by the luciferase reporter assay.	CHEMBL3740941	41-43	microRNA 1298	Homo sapiens	32-40
34386082-9	2021	The target relationship between miR-1298-5p and E2F1 was validated by the luciferase reporter assay.	CHEMBL3740941	41-43	E2F transcription factor 1	Homo sapiens	48-52
34540044-8	2021	DLR assay revealed a decreased luciferase activity after miR-497-5p binding to ROCK1 (P < 0.05).	CHEMBL3740941	65-67	microRNA 497	Homo sapiens	57-64
34522457-0	2021	MiR-374b-5p inhibits KDM5B-induced epithelial-mesenchymal transition in pancreatic cancer.	CHEMBL3740941	9-11	lysine demethylase 5B	Homo sapiens	21-26
34540044-8	2021	DLR assay revealed a decreased luciferase activity after miR-497-5p binding to ROCK1 (P < 0.05).	CHEMBL3740941	65-67	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	79-84
34234438-4	2021	MiR-126a-5p agomir was delivered to examine the effects of miR-126a-5p on I/R injury.	CHEMBL3740941	9-11	microRNA 126a	Rattus norvegicus	0-8
34118309-0	2021	Targeting HMGB1-TLR4 signaling by miR-216a-5p elevation alleviates the inflammatory behavioral hypersensitivity.	CHEMBL3740941	43-45	high mobility group box 1	Mus musculus	10-15
34118309-0	2021	Targeting HMGB1-TLR4 signaling by miR-216a-5p elevation alleviates the inflammatory behavioral hypersensitivity.	CHEMBL3740941	43-45	toll-like receptor 4	Mus musculus	16-20
34118309-7	2021	Intriguingly, transfection of HMGN1 cDNA into BV2 microglial cells reversed the inhibitory effects of miR-216a-5p elevation on microglial activation-triggered inflammatory response.	CHEMBL3740941	111-113	high mobility group nucleosomal binding domain 1	Mus musculus	30-35
34238666-9	2021	NEAT1/BACH1 silencing or let-7 g-5p elevation suppressed colon cancer cell growth in vivo and in vitro.	CHEMBL3740941	33-35	microRNA let-7g	Homo sapiens	25-32
34335948-10	2021	Furthermore, HDAC3-mediated histone deacetylation in promoter region of MIR627 was critical for hypoxia-mediated miR-627-5p repression.	CHEMBL3740941	121-123	histone deacetylase 3	Homo sapiens	13-18
34335948-10	2021	Furthermore, HDAC3-mediated histone deacetylation in promoter region of MIR627 was critical for hypoxia-mediated miR-627-5p repression.	CHEMBL3740941	121-123	microRNA 627	Homo sapiens	72-78
34335948-10	2021	Furthermore, HDAC3-mediated histone deacetylation in promoter region of MIR627 was critical for hypoxia-mediated miR-627-5p repression.	CHEMBL3740941	121-123	microRNA 627	Homo sapiens	113-120
35014213-11	2022	In vivo administration of miR-671-5p agomir decreased the messenger RNA and protein levels of Anpgt1 and VWF, and attenuated CCl4 -induced or BDL-induced liver angiogenesis and fibrosis.	CHEMBL3740941	34-36	microRNA 671	Mus musculus	26-33
34369270-13	2021	Finally, miR-361-5p inhibition rescued the suppressing effects of NEAT1 depletion on cell proliferation, invasion as well as Wnt pathway in CSCC.	CHEMBL3740941	17-19	microRNA 361	Homo sapiens	9-16
34369270-13	2021	Finally, miR-361-5p inhibition rescued the suppressing effects of NEAT1 depletion on cell proliferation, invasion as well as Wnt pathway in CSCC.	CHEMBL3740941	17-19	nuclear paraspeckle assembly transcript 1	Homo sapiens	66-71
34078519-4	2021	Used as a model system, gastric epithelial cells (GES-1) were transfected with miR-877-5p mimic/inhibitor, then treated with aspirin.	CHEMBL3740941	87-89	microRNA 877	Homo sapiens	79-86
34122108-11	2021	MiR-382-5p/SLC7A11 axis was involved in lidocaine-mediated inhibition of ovarian and breast cancer cell proliferation in vitro.	CHEMBL3740941	8-10	microRNA 382	Homo sapiens	0-7
34122108-11	2021	MiR-382-5p/SLC7A11 axis was involved in lidocaine-mediated inhibition of ovarian and breast cancer cell proliferation in vitro.	CHEMBL3740941	8-10	solute carrier family 7 member 11	Homo sapiens	11-18
35014213-11	2022	In vivo administration of miR-671-5p agomir decreased the messenger RNA and protein levels of Anpgt1 and VWF, and attenuated CCl4 -induced or BDL-induced liver angiogenesis and fibrosis.	CHEMBL3740941	34-36	Von Willebrand factor	Mus musculus	105-108
35590122-13	2022	Mechanistically, miR-6511b-5p suppresses invasion and migration of colorectal cancer cells through methylation of CD44 via directly targeting BRG1.	CHEMBL3740941	27-29	CD44 molecule (Indian blood group)	Homo sapiens	114-118
35590122-13	2022	Mechanistically, miR-6511b-5p suppresses invasion and migration of colorectal cancer cells through methylation of CD44 via directly targeting BRG1.	CHEMBL3740941	27-29	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	142-146
35602094-7	2022	The miR-299a-5p agomir prevents, while the miR-299a-5p antagomir exacerbates inflammation, oxidative stress, and SCI in mice.	CHEMBL3740941	13-15	microRNA 299a	Mus musculus	4-12
35596172-10	2022	We showed that the apoptotic markers, cleaved PARP and cleaved caspase-3, increased combining miR-675-5p inhibition with 5-FU treatment.	CHEMBL3740941	102-104	poly(ADP-ribose) polymerase 1	Homo sapiens	46-50
35596172-10	2022	We showed that the apoptotic markers, cleaved PARP and cleaved caspase-3, increased combining miR-675-5p inhibition with 5-FU treatment.	CHEMBL3740941	102-104	caspase 3	Homo sapiens	63-72
35596172-10	2022	We showed that the apoptotic markers, cleaved PARP and cleaved caspase-3, increased combining miR-675-5p inhibition with 5-FU treatment.	CHEMBL3740941	102-104	microRNA 675	Homo sapiens	94-101
35538149-14	2022	miR6891-5p inhibition causes H3K27me3 dysregulation and allelic skewing.	CHEMBL3740941	8-10	microRNA 6891	Homo sapiens	0-7
35128752-10	2022	Additionally, UBE2L3 was proved to be targeted and negatively regulated by miR-378a-5p, and UBE2L3 overexpression reversed the effects of miR-378a-5p upregulation.	CHEMBL3740941	84-86	ubiquitin conjugating enzyme E2 L3	Homo sapiens	14-20
35543246-8	2022	The binding relationship between miR-1247-5p and circEBF1 or CSF3 was verified by dual-luciferase reporter assay, RNA immunoprecipitation (RIP) assay and RNA pull-down assay.	CHEMBL3740941	42-44	microRNA 1247	Homo sapiens	33-41
35543246-8	2022	The binding relationship between miR-1247-5p and circEBF1 or CSF3 was verified by dual-luciferase reporter assay, RNA immunoprecipitation (RIP) assay and RNA pull-down assay.	CHEMBL3740941	42-44	colony stimulating factor 3	Homo sapiens	61-65
35571619-12	2022	LDHA restoration attenuated miR-33b-5p-mediated PTX sensitization.	CHEMBL3740941	36-38	lactate dehydrogenase A	Homo sapiens	0-4
35571619-12	2022	LDHA restoration attenuated miR-33b-5p-mediated PTX sensitization.	CHEMBL3740941	36-38	microRNA 33b	Homo sapiens	28-35
35128752-10	2022	Additionally, UBE2L3 was proved to be targeted and negatively regulated by miR-378a-5p, and UBE2L3 overexpression reversed the effects of miR-378a-5p upregulation.	CHEMBL3740941	84-86	microRNA 378a	Homo sapiens	75-83
35364125-8	2022	Furthermore, in differentiating NSPCs, GSI-induced shorter neurites could be partially rescued by miR-342-5p inhibitors, and STAT3 was one of the possible targets of miR-342-5p during this differentiating process as indicated by results of Western Blot test, luciferase reporter assay and GFP reporter assay.	CHEMBL3740941	106-108	microRNA 342	Rattus norvegicus	98-105
35582664-17	2022	miR-15b-5p inhibition or TLR4 overexpression averted the inhibitory effect of silencing XIST on HG-induced RTEC pyroptosis.	CHEMBL3740941	8-10	microRNA 15b	Rattus norvegicus	0-7
35485293-8	2022	In addition, ERK inhibitor U0126 attenuated the promotion effect of miR-497-5p inhibitor on activation of ERK/AKT and cell proliferation and migration.	CHEMBL3740941	76-78	mitogen-activated protein kinase 1	Homo sapiens	106-109
35485293-8	2022	In addition, ERK inhibitor U0126 attenuated the promotion effect of miR-497-5p inhibitor on activation of ERK/AKT and cell proliferation and migration.	CHEMBL3740941	76-78	AKT serine/threonine kinase 1	Homo sapiens	110-113
35049148-0	2022	Mechanism of miR-424-5p promoter methylation in promoting epithelial-mesenchymal transition of hepatocellular carcinoma cells.	CHEMBL3740941	21-23	microRNA 424	Homo sapiens	13-20
34380897-4	2022	To detect the neuroprotective effects of miR-491-p, neurological severity scores, Morris water maze test, laser speckle techniques, and immunofluorescence staining were assessed, and the results revealed that miR-491-5p downregulation alleviated neurological dysfunction, promoted the recovery of regional cerebral blood flow, increased the number of lectin-stained microvessels, and increased the survival of neurons after traumatic brain injury.	CHEMBL3740941	217-219	microRNA 491	Mus musculus	41-48
35083842-9	2022	The miR-30a-5p elevation could reverse the effects of enriched HOTAIR, while BNIP3 reduction abrogated the effects of KDM3A on CHF.	CHEMBL3740941	12-14	microRNA 30a	Mus musculus	4-11
35083842-9	2022	The miR-30a-5p elevation could reverse the effects of enriched HOTAIR, while BNIP3 reduction abrogated the effects of KDM3A on CHF.	CHEMBL3740941	12-14	HOX transcript antisense RNA (non-protein coding)	Mus musculus	63-69
34380897-4	2022	To detect the neuroprotective effects of miR-491-p, neurological severity scores, Morris water maze test, laser speckle techniques, and immunofluorescence staining were assessed, and the results revealed that miR-491-5p downregulation alleviated neurological dysfunction, promoted the recovery of regional cerebral blood flow, increased the number of lectin-stained microvessels, and increased the survival of neurons after traumatic brain injury.	CHEMBL3740941	217-219	microRNA 491	Mus musculus	209-216
34999254-9	2022	Under PDT treatment, WNT7B knockdown inhibited the Wnt signaling and cell viability, and promoted cell apoptosis, while miR-34a-5p suppression showed the opposite trends; WNT7B knockdown partially attenuated miR-34a-5p inhibition effects on PDT-treated cholangiocarcinoma cells.	CHEMBL3740941	216-218	Wnt family member 7B	Homo sapiens	21-26
35226569-0	2022	MicroRNA miR-34a-5p inhibition restrains oxidative stress injury of macrophages by targeting MDM4.	CHEMBL3740941	17-19	MDM4 regulator of p53	Homo sapiens	93-97
34999254-9	2022	Under PDT treatment, WNT7B knockdown inhibited the Wnt signaling and cell viability, and promoted cell apoptosis, while miR-34a-5p suppression showed the opposite trends; WNT7B knockdown partially attenuated miR-34a-5p inhibition effects on PDT-treated cholangiocarcinoma cells.	CHEMBL3740941	216-218	Wnt family member 7B	Homo sapiens	171-176
35020556-9	2022	The double luciferase reporter activity of the cotransfected STRN3-WT + miR-383-5p mimics group was significantly lower (by approximately 46%) than that of the other five groups (p < 0.01).	CHEMBL3740941	80-82	striatin 3	Gallus gallus	61-66
35020556-9	2022	The double luciferase reporter activity of the cotransfected STRN3-WT + miR-383-5p mimics group was significantly lower (by approximately 46%) than that of the other five groups (p < 0.01).	CHEMBL3740941	80-82	microRNA 383	Gallus gallus	72-79
35152215-0	2022	Involvement of miR-769-5p/Retinoic Acid Receptor Responder 1 Axis in the Progression of Osteosarcoma: Characterization of Potential Therapeutic Targets.	CHEMBL3740941	23-25	microRNA 769	Homo sapiens	15-22
34700372-0	2022	The miR526b-5p-Related Single Nucleotide Polymorphisms, rs72618599, Located in 3"-UTR of TCF3 Gene, is Associated with the Risk of Breast and Gastric Cancers.	CHEMBL3740941	12-14	microRNA 526b	Homo sapiens	4-11
34700372-0	2022	The miR526b-5p-Related Single Nucleotide Polymorphisms, rs72618599, Located in 3"-UTR of TCF3 Gene, is Associated with the Risk of Breast and Gastric Cancers.	CHEMBL3740941	12-14	transcription factor 3	Homo sapiens	89-93
35038704-13	2022	Moreover, silencing SOCS6 rescued the suppressive effect of miR-499-5p inhibition on HG-induced cell dysfunction.	CHEMBL3740941	68-70	suppressor of cytokine signaling 6	Homo sapiens	20-25
35038704-13	2022	Moreover, silencing SOCS6 rescued the suppressive effect of miR-499-5p inhibition on HG-induced cell dysfunction.	CHEMBL3740941	68-70	microRNA 499a	Homo sapiens	60-67
33838342-8	2021	After transfection with miR-431-5p mimics, proliferation of HRCECs was promoted, while transfection with miR-431-5p inhibitor demonstrated the opposite effect.	CHEMBL3740941	32-34	microRNA 431	Homo sapiens	24-31
33887878-12	2021	The EV-carried miR-125b-5p reduced the sensitivity of DLBCL cells to rituximab, which was averted by overexpression of TNFAIP3.	CHEMBL3740941	24-26	TNF alpha induced protein 3	Homo sapiens	119-126
35527005-0	2022	Dexmedetomidine attenuates acute stress-induced liver injury in rats by regulating the miR-34a-5p/ROS/JNK/p38 signaling pathway.	CHEMBL3740941	95-97	microRNA 34a	Rattus norvegicus	87-94
35527005-0	2022	Dexmedetomidine attenuates acute stress-induced liver injury in rats by regulating the miR-34a-5p/ROS/JNK/p38 signaling pathway.	CHEMBL3740941	95-97	mitogen-activated protein kinase 8	Rattus norvegicus	102-105
35527005-0	2022	Dexmedetomidine attenuates acute stress-induced liver injury in rats by regulating the miR-34a-5p/ROS/JNK/p38 signaling pathway.	CHEMBL3740941	95-97	mitogen activated protein kinase 14	Rattus norvegicus	106-109
34022287-0	2021	Long noncoding RNA SOX2OT silencing alleviates cerebral ischemia-reperfusion injury via miR-135a-5p-mediated NR3C2 inhibition.	CHEMBL3740941	97-99	SOX2 overlapping transcript (non-protein coding)	Mus musculus	19-25
33836245-10	2021	Moreover, miR-4422-5p-inhibitor reversed the expression processes in both cell lines.	CHEMBL3740941	19-21	microRNA 4422	Homo sapiens	10-18
34022287-0	2021	Long noncoding RNA SOX2OT silencing alleviates cerebral ischemia-reperfusion injury via miR-135a-5p-mediated NR3C2 inhibition.	CHEMBL3740941	97-99	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	109-114
33615686-4	2021	Human T-ALL cells (Jurkat) were transfected with Circ-PRKDC- or miR-653-5p-related sequences to investigate cell proliferation, apoptosis, and autophagy.	CHEMBL3740941	72-74	microRNA 653	Homo sapiens	64-71
33757716-9	2021	ED showed a specific epigenetic signature (lower miR214-5p and higher miR126-5p urinary levels).	CHEMBL3740941	56-58	microRNA 214	Homo sapiens	49-55
33977502-10	2021	Insulin-like growth factor 1 (IGF1) was found to be the target of miR-486-5p, and IGF1 overexpression notably reversed the effect of miR-486-5p inhibitor from HPVEC-Exo on trophoblast cell function.	CHEMBL3740941	74-76	insulin like growth factor 1	Homo sapiens	0-28
33977502-10	2021	Insulin-like growth factor 1 (IGF1) was found to be the target of miR-486-5p, and IGF1 overexpression notably reversed the effect of miR-486-5p inhibitor from HPVEC-Exo on trophoblast cell function.	CHEMBL3740941	74-76	insulin like growth factor 1	Homo sapiens	30-34
33977502-11	2021	In summary, H/R-treated HPVEC-derived exosomally expressing miR-486-5p inhibitor significantly inhibited the proliferation, migration and invasion of trophoblast cells via downregulation of IGF1.	CHEMBL3740941	68-70	insulin like growth factor 1	Homo sapiens	190-194
33958547-8	2021	The overexpression of miR-4787-5p significantly induced VSMC apoptosis, and miR-4787-5p knockdown showed the opposite results.	CHEMBL3740941	31-33	microRNA 4787	Homo sapiens	22-30
33791020-13	2021	Therefore, the present study revealed that TTTY15 knockdown improved the OGD/R-induced injury of PC12 cells by upregulating miR-766-5p expression.	CHEMBL3740941	132-134	testis-specific transcript, Y-linked 15	Homo sapiens	43-49
33078418-8	2021	Furthermore, the effects of PDK1-AS knockdown on VEGFA protein levels in the two cell lines were partially reversed by miR-125b-5p inhibition.	CHEMBL3740941	128-130	pyruvate dehydrogenase kinase 1	Homo sapiens	28-32
33675175-16	2021	MiR-671-5p knockdown attenuated the influence of circ-IQGAP1 interference on IL-1beta-caused chondrocyte apoptosis, inflammatory injury, and extracellular matrix degradation.	CHEMBL3740941	8-10	microRNA 671	Homo sapiens	0-7
33675175-16	2021	MiR-671-5p knockdown attenuated the influence of circ-IQGAP1 interference on IL-1beta-caused chondrocyte apoptosis, inflammatory injury, and extracellular matrix degradation.	CHEMBL3740941	8-10	IQ motif containing GTPase activating protein 1	Homo sapiens	54-60
33675175-16	2021	MiR-671-5p knockdown attenuated the influence of circ-IQGAP1 interference on IL-1beta-caused chondrocyte apoptosis, inflammatory injury, and extracellular matrix degradation.	CHEMBL3740941	8-10	interleukin 1 alpha	Homo sapiens	77-85
33078418-8	2021	Furthermore, the effects of PDK1-AS knockdown on VEGFA protein levels in the two cell lines were partially reversed by miR-125b-5p inhibition.	CHEMBL3740941	128-130	long intergenic non-protein coding RNA 2605	Homo sapiens	33-35
33078418-8	2021	Furthermore, the effects of PDK1-AS knockdown on VEGFA protein levels in the two cell lines were partially reversed by miR-125b-5p inhibition.	CHEMBL3740941	128-130	vascular endothelial growth factor A	Homo sapiens	49-54
33651374-9	2021	RESULTS: miR-378a-5p expression was significantly increased after OGDR at 24 h and 48 h. After OGDR, cell viability was reduced, which was reversed by miR-378a-5p and enhanced by shCAMKK2 plasmid.	CHEMBL3740941	18-20	microRNA 378	Rattus norvegicus	151-159
33477007-0	2021	Circulating miR-30b-5p levels in plasma as a novel potential biomarker for early detection of breast cancer.	CHEMBL3740941	20-22	microRNA 30b	Homo sapiens	12-19
33144185-4	2021	The experimental data indicated that miR-937-5p inhibition significantly repressed the proliferation of breast carcinoma cells and elicited S-phase cell cycle arrest.	CHEMBL3740941	45-47	microRNA 937	Homo sapiens	37-44
33189302-8	2021	HCP5 could competitively bind miR-186-5p, while miR-186-5p could target the 3"-UTR of MAP3K2.	CHEMBL3740941	38-40	HLA complex P5	Homo sapiens	0-4
33500694-7	2021	It was demonstrated that miR-361-5p inhibitor significantly reduced the viability of SKOV3 cells and induced apoptosis.	CHEMBL3740941	33-35	microRNA 361	Homo sapiens	25-32
33279663-9	2021	MAGI2-AS3 reduction enhanced neuronal viability and attenuated neuroinflammation in AD cell models, and miR-374b-5p overexpression led to same effects, but miR-374b-5p inhibition reversed these effects.	CHEMBL3740941	113-115	microRNA 374b	Mus musculus	104-112
33376519-13	2021	In addition, miRNA-485-5p level was negatively correlated with that of LINC00488.	CHEMBL3740941	23-25	long intergenic non-protein coding RNA 488	Homo sapiens	71-80
33420269-9	2021	miR299a-5p inhibition protected these mice against renal fibrosis and CKD severity.	CHEMBL3740941	8-10	microRNA 299a	Mus musculus	0-7
33420269-11	2021	Thus, miR299a-5p inhibition offers a potential novel therapeutic approach for CKD.	CHEMBL3740941	14-16	microRNA 299a	Mus musculus	6-13
33335425-12	2020	Moreover, the cancer-inhibiting activities of LINC01426 knockdown in NSCLC cells were partially offset by miR-519d-5p inhibition.	CHEMBL3740941	115-117	long intergenic non-protein coding RNA 1426	Homo sapiens	46-55
33613103-11	2021	In vivo evidences demonstrated that intratumoral injection of miR-619-5p agomir remarkably slowed down the growth of OSCC in xenograft mice.	CHEMBL3740941	70-72	microRNA 619	Homo sapiens	62-69
33324643-8	2020	Uptake of exosomes derived from the hypoxic TECs by macrophages would trigger M1 polarization via transferring miR-374b-5p.	CHEMBL3740941	120-122	microRNA 374b	Mus musculus	111-119
33125110-7	2020	It was also observed that RP11-619L19.2 was reciprocally repressed by miR-1271-5p.	CHEMBL3740941	79-81	pre-mRNA processing factor 31	Homo sapiens	26-30
33125110-7	2020	It was also observed that RP11-619L19.2 was reciprocally repressed by miR-1271-5p.	CHEMBL3740941	79-81	microRNA 1271	Homo sapiens	70-78
33299881-5	2020	Results of alkaline phosphatase (ALP) and Alizarin Red S (ARS) staining indicated that upregulation of miR-346-5p suppressed osteogenic differentiation of BMSCs, whereas downregulation of miR-346-5p enhanced this process.	CHEMBL3740941	111-113	secreted LY6/PLAUR domain containing 1	Homo sapiens	58-61
33299881-5	2020	Results of alkaline phosphatase (ALP) and Alizarin Red S (ARS) staining indicated that upregulation of miR-346-5p suppressed osteogenic differentiation of BMSCs, whereas downregulation of miR-346-5p enhanced this process.	CHEMBL3740941	111-113	microRNA 346	Homo sapiens	103-110
32738187-14	2020	Importantly, co-transfection experiments indicated that SLC29A3 can reverse miR-1224-5p-mediated inhibition in the malignant progression of RC cells.	CHEMBL3740941	85-87	solute carrier family 29 member 3	Homo sapiens	56-63
33329055-7	2020	Exosomal miR-769-5p expression was significantly upregulated.	CHEMBL3740941	17-19	microRNA 769	Homo sapiens	9-16
32672363-8	2020	Administration of miR-1249-5p agomir decreases hepatic MCP-1 levels and attenuates liver inflammation in MCDHF mice.	CHEMBL3740941	27-29	chemokine (C-C motif) ligand 2	Mus musculus	55-60
32749665-11	2020	Moreover, miR590-5p inhibitor can attenuate the effect of DUXAP8 interference on ovarian cancer cells.	CHEMBL3740941	17-19	microRNA 590	Homo sapiens	10-16
32749665-11	2020	Moreover, miR590-5p inhibitor can attenuate the effect of DUXAP8 interference on ovarian cancer cells.	CHEMBL3740941	17-19	double homeobox A pseudogene 8	Homo sapiens	58-64
32985665-10	2020	FGF1 was the target of miR-361-5p, and overexpressed FGF1 reversed the effects of upregulating miR-361-5p on suppressing EPCs.	CHEMBL3740941	31-33	fibroblast growth factor 1	Rattus norvegicus	0-4
32985665-10	2020	FGF1 was the target of miR-361-5p, and overexpressed FGF1 reversed the effects of upregulating miR-361-5p on suppressing EPCs.	CHEMBL3740941	31-33	microRNA 361	Rattus norvegicus	23-30
32700749-13	2020	miR-135b-5p agomir significantly enhanced the anti-proliferative effect of trastuzumab on HER-2-positive breast cancer cells via the induction of apoptosis, whereas the anti-metastatic effect of trastuzumab was enhanced by miR-135b-5p agomir treatment.	CHEMBL3740941	9-11	erb-b2 receptor tyrosine kinase 2	Homo sapiens	90-95
32738187-14	2020	Importantly, co-transfection experiments indicated that SLC29A3 can reverse miR-1224-5p-mediated inhibition in the malignant progression of RC cells.	CHEMBL3740941	85-87	microRNA 1224	Homo sapiens	76-84
33061615-13	2020	MiR-491-5p inhibition abrogated the activities of proliferation, apoptosis, migration and invasion affected by H19 knockdown.	CHEMBL3740941	8-10	microRNA 491	Homo sapiens	0-7
33061615-13	2020	MiR-491-5p inhibition abrogated the activities of proliferation, apoptosis, migration and invasion affected by H19 knockdown.	CHEMBL3740941	8-10	H19 imprinted maternally expressed transcript	Homo sapiens	111-114
32998623-10	2021	The expressions of IL-1beta and iNOS were down-regulated, while the protein expressions of CCL17 and Arg-1 were up-regulated by miR-145-5p mimic in M0.	CHEMBL3740941	136-138	interleukin 1 alpha	Homo sapiens	19-27
32998623-10	2021	The expressions of IL-1beta and iNOS were down-regulated, while the protein expressions of CCL17 and Arg-1 were up-regulated by miR-145-5p mimic in M0.	CHEMBL3740941	136-138	C-C motif chemokine ligand 17	Homo sapiens	91-96
32998623-10	2021	The expressions of IL-1beta and iNOS were down-regulated, while the protein expressions of CCL17 and Arg-1 were up-regulated by miR-145-5p mimic in M0.	CHEMBL3740941	136-138	arginase 1	Homo sapiens	101-106
32998623-10	2021	The expressions of IL-1beta and iNOS were down-regulated, while the protein expressions of CCL17 and Arg-1 were up-regulated by miR-145-5p mimic in M0.	CHEMBL3740941	136-138	microRNA 145	Homo sapiens	128-135
33003647-15	2020	MiR-342-3p/-5p-based intervention or monitoring may prove to be beneficial in managing CVD.	CHEMBL3740941	12-14	microRNA 342	Homo sapiens	0-7
32782437-12	2020	Conclusions: Our results showed that Tan IIA could inhibit cell proliferation in AML cells through miR-497-5p-mediated AKT3 downregulation pathway.	CHEMBL3740941	107-109	microRNA 497	Homo sapiens	99-106
32705273-11	2020	The TGFbeta1 induced p-Smad3 expression in HK-2 and HMCs, which could be attenuated by miR-135a-5p knockdown via SIRT1.	CHEMBL3740941	96-98	transforming growth factor beta 1	Homo sapiens	4-12
32705273-11	2020	The TGFbeta1 induced p-Smad3 expression in HK-2 and HMCs, which could be attenuated by miR-135a-5p knockdown via SIRT1.	CHEMBL3740941	96-98	SMAD family member 3	Homo sapiens	23-28
32705273-11	2020	The TGFbeta1 induced p-Smad3 expression in HK-2 and HMCs, which could be attenuated by miR-135a-5p knockdown via SIRT1.	CHEMBL3740941	96-98	hexokinase 2	Homo sapiens	43-47
32705273-11	2020	The TGFbeta1 induced p-Smad3 expression in HK-2 and HMCs, which could be attenuated by miR-135a-5p knockdown via SIRT1.	CHEMBL3740941	96-98	molybdenum cofactor sulfurase	Homo sapiens	52-56
32705273-11	2020	The TGFbeta1 induced p-Smad3 expression in HK-2 and HMCs, which could be attenuated by miR-135a-5p knockdown via SIRT1.	CHEMBL3740941	96-98	sirtuin 1	Homo sapiens	113-118
32782437-12	2020	Conclusions: Our results showed that Tan IIA could inhibit cell proliferation in AML cells through miR-497-5p-mediated AKT3 downregulation pathway.	CHEMBL3740941	107-109	AKT serine/threonine kinase 3	Homo sapiens	119-123
32597559-10	2020	Up-regulation of miR-1207-5p alleviated the LPS-induced damage in the view of cell proliferation, apoptosis and extracellular matrix (ECM) degradation.	CHEMBL3740941	26-28	microRNA 1207	Homo sapiens	17-25
32801906-10	2020	Moreover, overexpression of miR-424-5p partially suppressed the previously high cell viability, migration, and invasion, and activated EMT resulted from up-regulation of CDKN2B-AS1, while silencing of miR-424-5p elevated the cellular processes inhibited by silencing the expression of CDKN2B-AS1.	CHEMBL3740941	36-38	microRNA 424	Homo sapiens	28-35
32801906-10	2020	Moreover, overexpression of miR-424-5p partially suppressed the previously high cell viability, migration, and invasion, and activated EMT resulted from up-regulation of CDKN2B-AS1, while silencing of miR-424-5p elevated the cellular processes inhibited by silencing the expression of CDKN2B-AS1.	CHEMBL3740941	36-38	CDKN2B antisense RNA 1	Homo sapiens	170-180
32801906-10	2020	Moreover, overexpression of miR-424-5p partially suppressed the previously high cell viability, migration, and invasion, and activated EMT resulted from up-regulation of CDKN2B-AS1, while silencing of miR-424-5p elevated the cellular processes inhibited by silencing the expression of CDKN2B-AS1.	CHEMBL3740941	36-38	microRNA 424	Homo sapiens	201-208
32801906-10	2020	Moreover, overexpression of miR-424-5p partially suppressed the previously high cell viability, migration, and invasion, and activated EMT resulted from up-regulation of CDKN2B-AS1, while silencing of miR-424-5p elevated the cellular processes inhibited by silencing the expression of CDKN2B-AS1.	CHEMBL3740941	36-38	CDKN2B antisense RNA 1	Homo sapiens	285-295
32333091-5	2020	Functionally, miR-767-5p-overexpressing cells had a significantly higher proliferative, migratory, and invasive potential, and exhibited an enhanced anchorage-dependent clonogenesis and a tumor formation potential in vivo.	CHEMBL3740941	22-24	microRNA 767	Homo sapiens	14-21
32690599-11	2020	Downregulated miR-30b-5p exerted the opposite effect.	CHEMBL3740941	22-24	microRNA 30b	Homo sapiens	14-21
32445843-11	2020	RESULTS: Microarray and qRT-PCR results showed that the IL-10 expression was decreased while miR-374b-5p level was increased substantially in peripheral blood mononuclear cells of DVT patients, and there was significant negative correlation between miR-374b-5p and IL-10.	CHEMBL3740941	102-104	microRNA 374b	Homo sapiens	93-101
32240501-11	2020	The protein levels of MKP-1 in the EA+let-7b-5p antagomir group were significantly higher than in the EA + let-7b-5p agomir group.	CHEMBL3740941	45-47	dual specificity phosphatase 1	Rattus norvegicus	22-27
32240501-12	2020	However, P-p38MAPK in the EA+let-7b-5p antagomir group was significantly lower than in the EA+let-7b-5p agomir group.	CHEMBL3740941	36-38	mitogen activated protein kinase 14	Rattus norvegicus	11-18
32627648-8	2021	MIR106A-5p overexpression in NPC was due to increased transactivation by EGR1 and SOX9.	CHEMBL3740941	8-10	early growth response 1	Homo sapiens	73-77
32627648-8	2021	MIR106A-5p overexpression in NPC was due to increased transactivation by EGR1 and SOX9.	CHEMBL3740941	8-10	SRY-box transcription factor 9	Homo sapiens	82-86
32546573-9	2020	miR27a-5p inhibition mitigated TNF-induced (1) delayed wound closure, increased (2) adhesion and (3) transendothelial migration but did not alter permeability.	CHEMBL3740941	7-9	microRNA 27a	Mus musculus	0-6
32546573-9	2020	miR27a-5p inhibition mitigated TNF-induced (1) delayed wound closure, increased (2) adhesion and (3) transendothelial migration but did not alter permeability.	CHEMBL3740941	7-9	tumor necrosis factor	Homo sapiens	31-34
32548991-0	2020	Circulating miR-374b-5p negatively regulates osteoblast differentiation in the progression of osteoporosis via targeting Wnt3 AND Runx2.	CHEMBL3740941	21-23	wingless-type MMTV integration site family, member 3	Mus musculus	121-125
32635799-4	2020	Results: Patients who were primary resistant to EGFR-tyrosine kinase inhibitor had lower miR-365a-5p levels.	CHEMBL3740941	98-100	epidermal growth factor receptor	Homo sapiens	48-52
32373939-8	2020	Further, rescued-function assays suggested that the suppressive influence of EGOT depletion on CRC progression was reversed by miR-33b-5p inhibition or CROT overexpression.	CHEMBL3740941	135-137	eosinophil granule ontogeny transcript	Homo sapiens	77-81
32373939-8	2020	Further, rescued-function assays suggested that the suppressive influence of EGOT depletion on CRC progression was reversed by miR-33b-5p inhibition or CROT overexpression.	CHEMBL3740941	135-137	microRNA 33b	Homo sapiens	127-134
32112903-8	2020	Further in vivo experiments demonstrated that miR-30b-5p overexpression inhibited CRLM, but Rap1b rescue attenuated the inhibitory effect of miR-30b-5p.	CHEMBL3740941	54-56	microRNA 30b	Homo sapiens	46-53
32149330-5	2020	The relationship among XIST, miR-125b-5p and tribbles homolog 2 (TRIB2) was predicted by starBase v2.0 or TargetScan and confirmed by Dual-luciferase reporter assay.	CHEMBL3740941	38-40	tribbles pseudokinase 2	Homo sapiens	45-63
32149330-5	2020	The relationship among XIST, miR-125b-5p and tribbles homolog 2 (TRIB2) was predicted by starBase v2.0 or TargetScan and confirmed by Dual-luciferase reporter assay.	CHEMBL3740941	38-40	tribbles pseudokinase 2	Homo sapiens	65-70
32149330-11	2020	Moreover, XIST-loss-induced downregulation of TRIB2 could be significantly reversed by miR-125b-5p knockdown.	CHEMBL3740941	96-98	X inactive specific transcript	Homo sapiens	10-14
32149330-11	2020	Moreover, XIST-loss-induced downregulation of TRIB2 could be significantly reversed by miR-125b-5p knockdown.	CHEMBL3740941	96-98	tribbles pseudokinase 2	Homo sapiens	46-51
32203196-5	2021	Our experiments showed that the levels of cell apoptosis and fatty acid accumulation were decreased in THP-1 macrophages treated with miR-140-5p mimic, whereas increased in those treated with miR-140-5p inhibitor.	CHEMBL3740941	142-144	GLI family zinc finger 2	Homo sapiens	103-108
32121598-7	2020	A miR155-5p mimic inhibited, and a miR155-5p inhibitor promoted the migration of VSMC of SHR but had no significant effect on the migration of VSMC of WKY.	CHEMBL3740941	9-11	microRNA 155	Rattus norvegicus	2-8
32548991-0	2020	Circulating miR-374b-5p negatively regulates osteoblast differentiation in the progression of osteoporosis via targeting Wnt3 AND Runx2.	CHEMBL3740941	21-23	microRNA 374b	Mus musculus	12-20
32606929-5	2020	Then, the correlations between miR-379-5p expression in NPC tissues and clinicopathologic features and patients" prognosis were analyzed.	CHEMBL3740941	39-41	microRNA 379	Homo sapiens	31-38
32315535-16	2020	The rescue experiments clarified that miR-217-5p inhibitor attenuated the suppression of HOTAIR silencing on HCC cell proliferation, migration, invasion, and EMT.	CHEMBL3740941	46-48	HOX transcript antisense RNA	Homo sapiens	89-95
32246817-5	2020	Five differential miRNAs with most significant difference, including miR-21-5p, miR-34-5p, miR-1246, miR-4488 and miR-494, were obtainable after silencing of DGCR8.	CHEMBL3740941	76-78	microRNA 21	Homo sapiens	69-75
32246817-5	2020	Five differential miRNAs with most significant difference, including miR-21-5p, miR-34-5p, miR-1246, miR-4488 and miR-494, were obtainable after silencing of DGCR8.	CHEMBL3740941	76-78	DGCR8 microprocessor complex subunit	Homo sapiens	158-163
32098588-7	2020	In addition, miR-384-5p agomir significantly repressed mechanical allodynia and heat hyperalgesia in CCI rats.	CHEMBL3740941	21-23	microRNA 384	Rattus norvegicus	13-20
32152275-0	2020	HIF1A activates the transcription of lncRNA RAET1K to modulate hypoxia-induced glycolysis in hepatocellular carcinoma cells via miR-100-5p.	CHEMBL3740941	136-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-5
32152275-0	2020	HIF1A activates the transcription of lncRNA RAET1K to modulate hypoxia-induced glycolysis in hepatocellular carcinoma cells via miR-100-5p.	CHEMBL3740941	136-138	retinoic acid early transcript 1K pseudogene	Homo sapiens	44-50
32548991-0	2020	Circulating miR-374b-5p negatively regulates osteoblast differentiation in the progression of osteoporosis via targeting Wnt3 AND Runx2.	CHEMBL3740941	21-23	runt related transcription factor 2	Mus musculus	130-135
32175269-4	2020	The main objective of this paper is to explore miR-15b-5p effects and their mechanisms in breast cancer using both in vitro and in vivo experiments.	CHEMBL3740941	55-57	microRNA 15b	Homo sapiens	47-54
32161467-9	2020	As to mechanism investigation, rescue experiments revealed that miR-485-5p inhibitor could partially reverse the effects on CC cells induced by SNHG7 knockdown.	CHEMBL3740941	72-74	small nucleolar RNA host gene 7	Homo sapiens	144-149