PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33812073-6 2021 Moreover, CuS-ATMi@TGF-beta NPs specifically target tumors and thereby significantly inhibit tumor growth on contribution to synergistic low-temperature PTT and chemotherapy. Bialaphos 153-156 transforming growth factor alpha Homo sapiens 19-27 10419734-9 1999 Although serum hCG levels progressively decreased during pregnancy in one patient without PTT, hCG levels initially decreased, but subsequently increased or showed a plateau with advancing gestational age in two patients with PTT. Bialaphos 226-229 hypertrichosis 2 (generalised, congenital) Homo sapiens 95-98 34726226-6 2021 Through dual-modality US/PA imaging monitoring, PDA-PVAMBs@GOx with long-term retention (~7 days) combined with PTT and TPZ significantly inhibited the growth of solid tumors with minimum systemic side effects, which might be a powerful tool for effective tumor treatment. Bialaphos 112-115 hydroxyacid oxidase 1 Homo sapiens 59-62 34952286-5 2022 This work provides a simple reproducible method to fabricate the water-soluble and biocompatible Ag2S NPs, which would provide new insights of designing new functional NPs for the PTT therapy of tumor. Bialaphos 180-183 angiotensin II receptor type 1 Homo sapiens 97-101 34786942-2 2021 Herein, MoS2@PDA-Fe@PEG/TPP (MPFPT) nanosheets (NSs) with mitochondria-targeting ability were reported for enhanced PTT-CDT synergistic oncotherapy. Bialaphos 116-119 mago homolog, exon junction complex core component Mus musculus 8-12 34635886-5 2021 As a result, HSP was remarkably suppressed for enhancing PTT efficacy upon mild near-infrared light irradiation. Bialaphos 57-60 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 13-16 34593005-6 2021 METHODS: Metformin (Met) down-regulates NADH/NADPH, promotes the FAO of CD8+ T cells by activating AMPK, increases the number of CD8+ TCM, which boosts the long-term immune memory of tumor-bearing mice treated with PTT. Bialaphos 215-218 protein kinase AMP-activated catalytic subunit alpha 2 Rattus norvegicus 99-103 34579760-7 2021 The HCT-8 cells treated with the Au NR@PAMAM-GX1/FAM172A under laser irradiation have a viability of 20.45%, which is much lower than the survival rate of other single-mode PTT treatment or single-mode gene therapy. Bialaphos 173-176 family with sequence similarity 172 member A Homo sapiens 49-56 34544447-4 2021 Thus, a combination of HSP90 inhibitor and photothermal photosensitizer is expected to significantly enhance antitumor efficacy of PTT through hyperthermia sensitization. Bialaphos 131-134 heat shock protein, 3 Mus musculus 23-28 34269521-6 2021 Hsp90alpha, one subunit of heat shock protein 90 (Hsp90), is targeted by Cas9 RNP to reduce tumor heat tolerance for enhanced mild-PTT effects ( 43 C). Bialaphos 131-134 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-10 34269521-6 2021 Hsp90alpha, one subunit of heat shock protein 90 (Hsp90), is targeted by Cas9 RNP to reduce tumor heat tolerance for enhanced mild-PTT effects ( 43 C). Bialaphos 131-134 heat shock protein 90 alpha family class A member 1 Homo sapiens 27-48 34269521-6 2021 Hsp90alpha, one subunit of heat shock protein 90 (Hsp90), is targeted by Cas9 RNP to reduce tumor heat tolerance for enhanced mild-PTT effects ( 43 C). Bialaphos 131-134 heat shock protein 90 alpha family class A member 1 Homo sapiens 50-55 35589680-6 2022 In addition, Cal/ICG@MPs-triggered CAF regulation enhances tumor infiltration of CD8+ T cells and ameliorates CAF-induced antigen-mediated activation-induced cell death of tumor-specific CD8+ T cells in response to PTT, eliciting long-term antitumor immune memory to inhibit tumor recurrence and metastasis. Bialaphos 215-218 CD8a molecule Homo sapiens 81-84 34160212-5 2021 Both in vitro and in vivo experiments demonstrated that such Au-RRVR nanoparticles could be simultaneously induced by furin and acidic pH to form large aggregates within tumorous tissue resulting in improved tumor accumulation and retention, which can further activate the PA and PTT effect of AuNPs for sensitive imaging and efficient therapy of tumors. Bialaphos 280-283 furin, paired basic amino acid cleaving enzyme Homo sapiens 118-123 35589680-6 2022 In addition, Cal/ICG@MPs-triggered CAF regulation enhances tumor infiltration of CD8+ T cells and ameliorates CAF-induced antigen-mediated activation-induced cell death of tumor-specific CD8+ T cells in response to PTT, eliciting long-term antitumor immune memory to inhibit tumor recurrence and metastasis. Bialaphos 215-218 CD8a molecule Homo sapiens 187-190 35442630-7 2022 In vitro experiments showed that PMS could inhibit the expression of heat shock protein (HSP) by damaging the mitochondria, thereby finally improving the effect of mild-temperature PTT. Bialaphos 181-184 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 69-87 35442630-7 2022 In vitro experiments showed that PMS could inhibit the expression of heat shock protein (HSP) by damaging the mitochondria, thereby finally improving the effect of mild-temperature PTT. Bialaphos 181-184 heat shock protein 90 beta family member 2, pseudogene Homo sapiens 89-92 35217073-9 2022 In conclusion, these results demonstrated that ICG-ZHer3 is a promising photosensitizer for PTT against Her3-positive tumors. Bialaphos 92-95 erb-b2 receptor tyrosine kinase 3 Homo sapiens 104-108 33656325-5 2021 The three-in-one functions of oxygen supply, glucose consumption, and photothermal conversion were realized in the ZIFs-derived CuCo(O)/GOx@PCNs nanozyme and the starvation therapy effect was improved by PTT and oxygen supplement. Bialaphos 204-207 hydroxyacid oxidase 1 Homo sapiens 136-139 35215251-7 2022 Additionally, the released 1-M-DT inhibited IDO and combined with TAAs to enhance maturation of dendritic cells (DCs), indicating the excellent synergistic effect of PTT and NO with IDO inhibitors. Bialaphos 166-169 indoleamine 2,3-dioxygenase 1 Homo sapiens 44-47 35215251-8 2022 These results revealed that this dual-sensitive nanoparticle presented a combination strategy of PTT/NO/IDO for the synergistic effect to promote DC maturation. Bialaphos 97-100 indoleamine 2,3-dioxygenase 1 Homo sapiens 104-107 33893670-8 2021 It is observed that the PTT treatment of GBM-bearing mice activates natural killer cells, CD3+ T cells, CD8+ T cells, and M1 macrophages in the GBM area, increasing the therapeutic efficacy. Bialaphos 24-27 CD247 antigen Mus musculus 90-93 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 31-34 tumor necrosis factor Homo sapiens 133-160 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 31-34 tumor necrosis factor Homo sapiens 162-171 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 31-34 interleukin 6 Homo sapiens 174-187 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 31-34 interleukin 6 Homo sapiens 189-193 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 31-34 interleukin 1 beta Homo sapiens 200-217 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 31-34 interleukin 1 alpha Homo sapiens 219-227 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 105-108 tumor necrosis factor Homo sapiens 133-160 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 105-108 tumor necrosis factor Homo sapiens 162-171 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 105-108 interleukin 6 Homo sapiens 174-187 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 105-108 interleukin 6 Homo sapiens 189-193 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 105-108 interleukin 1 beta Homo sapiens 200-217 33899283-7 2021 Ultimately, this gas-modulated PTT strategy inhibits tumor growth remarkably and limits the magnitude of PTT-induced proinflammatory tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1beta (IL-1beta) cytokines. Bialaphos 105-108 interleukin 1 alpha Homo sapiens 219-227 33714187-6 2021 In vivo antitumor studies reveal that HA-AuNR/M-M2pep NPs-mediated PTT and M2-TAMs depletion recruit TILs, activate effector T lymphocytes, secrete antitumor cytokines (e.g. IFN-gamma, TNF-alpha), and effectively inhibit the growth of tumor. Bialaphos 67-70 interferon gamma Homo sapiens 174-183 33714187-6 2021 In vivo antitumor studies reveal that HA-AuNR/M-M2pep NPs-mediated PTT and M2-TAMs depletion recruit TILs, activate effector T lymphocytes, secrete antitumor cytokines (e.g. IFN-gamma, TNF-alpha), and effectively inhibit the growth of tumor. Bialaphos 67-70 tumor necrosis factor Homo sapiens 185-194 33407570-7 2021 In addition, the release of GA was promoted by irradiation to bind with Hsp90, which could reduce cell tolerance to heat for PTT enhancement. Bialaphos 125-128 heat shock protein 90 alpha family class A member 1 Homo sapiens 72-77 32641992-7 2020 The GOx-mediated tumor starvation strategy would directly suppress the expression of HSP70 and HSP90, resulting in an enhanced low-temperature PTT induced by PDA nanocore. Bialaphos 143-146 hydroxyacid oxidase 1 Homo sapiens 4-7 33200159-2 2020 In the present study, glucose oxidase (GOx) was decorated on N-doped carbon (NC) nanoparticles (NPs) as a biomimetic nanoenzyme (NC@GOx NPs), which could promote starvation therapy enhanced PTT and CDT against tumors. Bialaphos 190-193 hydroxyacid oxidase 1 Homo sapiens 22-37 33200159-2 2020 In the present study, glucose oxidase (GOx) was decorated on N-doped carbon (NC) nanoparticles (NPs) as a biomimetic nanoenzyme (NC@GOx NPs), which could promote starvation therapy enhanced PTT and CDT against tumors. Bialaphos 190-193 hydroxyacid oxidase 1 Homo sapiens 39-42 33200159-2 2020 In the present study, glucose oxidase (GOx) was decorated on N-doped carbon (NC) nanoparticles (NPs) as a biomimetic nanoenzyme (NC@GOx NPs), which could promote starvation therapy enhanced PTT and CDT against tumors. Bialaphos 190-193 hydroxyacid oxidase 1 Homo sapiens 132-135 32641992-7 2020 The GOx-mediated tumor starvation strategy would directly suppress the expression of HSP70 and HSP90, resulting in an enhanced low-temperature PTT induced by PDA nanocore. Bialaphos 143-146 heat shock protein family A (Hsp70) member 4 Homo sapiens 85-90 32641992-7 2020 The GOx-mediated tumor starvation strategy would directly suppress the expression of HSP70 and HSP90, resulting in an enhanced low-temperature PTT induced by PDA nanocore. Bialaphos 143-146 heat shock protein 90 alpha family class A member 1 Homo sapiens 95-100 32096524-2 2020 Herein, a metal-phenolic network-based multifunctional nanocomposite (PID@Fe-TA) via the noncovalent interaction of multiple nontoxic raw materials has been designed to integrate the synergistic effect of CDT, photothermal therapy (PTT) and chemotherapy into one nanoplatform for breast cancer treatment. Bialaphos 232-235 metastasis associated 1 family member 2 Homo sapiens 70-73 30030176-5 2018 By combining catalysis with near-infrared (NIR) photothermal therapy, the PDA@Au-HAp NPs provide safe, rapid, and effective antibacterial activity compared to OH or PTT alone. Bialaphos 165-168 hemaglutinin-associated protein Escherichia coli 81-84 33455391-3 2020 Specifically, 2-phenylethynesulfonamide (PES), an inhibitor of heat shock protein 70 (HSP-70), was loaded into the NO nanogenerators to realize effective low-temperature (~45 C) PTT. Bialaphos 179-182 heat shock protein family A (Hsp70) member 4 Homo sapiens 86-92 30590240-4 2019 NPICS can effectively restrain the expression of HSP70 to reduce their endurance to the IR825-mediated PTT, leading to an enhanced photocytotoxicity. Bialaphos 103-106 heat shock protein 1B Mus musculus 49-54 30128038-6 2018 Conclusion: Our study demonstrated that the Cu-TCPP MOF nanosheets are a promising phototherapy nanoplatform with the synergistic ability for PTT and PDT of cancer, guided by MR and infrared thermal imaging. Bialaphos 142-145 K(lysine) acetyltransferase 8 Mus musculus 52-55 29532899-9 2018 In addition, PTT group presented a significant association with MMP-1 and MMP-8 gene polymorphisms. Bialaphos 13-16 matrix metallopeptidase 1 Homo sapiens 64-69 29532899-9 2018 In addition, PTT group presented a significant association with MMP-1 and MMP-8 gene polymorphisms. Bialaphos 13-16 matrix metallopeptidase 8 Homo sapiens 74-79 30085649-2 2018 Here, we report an activatable dual-modal imaging agent, which is based on PEGylated-gadolinium metallofullerene-polypyrrole nanoparticle (PEG-GMF-PPy NP) for imaging-guided PTT. Bialaphos 174-177 glia maturation factor beta Homo sapiens 143-146 29938191-4 2018 To improve the therapy efficiency as a PTT agent, the MCP NPs are further modified with functional polyethylene glycol (PEG) and thiol terminal cyclic arginine-glycine-aspartic acid peptide, respectively: the first one is to increase the stability, biocompatibility, and blood circulation time of MCP NPs in vivo; the second one is to increase the tumor accumulation of MCP-PEG NPs and improve their therapeutic efficiency as photothermal agent. Bialaphos 39-42 CD46 molecule Homo sapiens 54-57 28892609-5 2017 The CP3 NPs show a high PA signal to background ratio of 47 in U87 tumor-bearing mice, which is superior to other reported PA/PTT theranostic agents. Bialaphos 126-129 peroxiredoxin 6 Mus musculus 4-7 28441474-6 2017 In vitro cell viability assay data show that cells treated with the G5-MoS2/Bcl-2 siRNA polyplexes under laser irradiation have a viability of 21.0%, which is much lower than other groups of single mode PTT treatment (45.8%) or single mode of gene therapy (68.7%). Bialaphos 203-206 mago homolog, exon junction complex core component Mus musculus 71-75 28441474-6 2017 In vitro cell viability assay data show that cells treated with the G5-MoS2/Bcl-2 siRNA polyplexes under laser irradiation have a viability of 21.0%, which is much lower than other groups of single mode PTT treatment (45.8%) or single mode of gene therapy (68.7%). Bialaphos 203-206 B cell leukemia/lymphoma 2 Mus musculus 76-81 26979315-2 2016 AChE was immobilized on PTT film surface through the covalent bond between aldehyde and amino groups. Bialaphos 24-27 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 27576159-3 2016 In this report, we hypothesized that, by targeting CD44 (one TNBC-overexpressed surface molecule) and depleting heat shock protein 72 (HSP72, one malignancy-specific-overexpressed thermotolerance-related chaperone) subsequently, the TNBC could be selectively sensitized to PTT and improve the accuracy of treatment. Bialaphos 273-276 CD44 molecule (Indian blood group) Homo sapiens 51-55 27576159-3 2016 In this report, we hypothesized that, by targeting CD44 (one TNBC-overexpressed surface molecule) and depleting heat shock protein 72 (HSP72, one malignancy-specific-overexpressed thermotolerance-related chaperone) subsequently, the TNBC could be selectively sensitized to PTT and improve the accuracy of treatment. Bialaphos 273-276 heat shock protein family A (Hsp70) member 1A Homo sapiens 112-133 27576159-3 2016 In this report, we hypothesized that, by targeting CD44 (one TNBC-overexpressed surface molecule) and depleting heat shock protein 72 (HSP72, one malignancy-specific-overexpressed thermotolerance-related chaperone) subsequently, the TNBC could be selectively sensitized to PTT and improve the accuracy of treatment. Bialaphos 273-276 heat shock protein family A (Hsp70) member 1A Homo sapiens 135-140 26646625-5 2016 The in vitro and in vivo studies demonstrate the ability of the GNRs-siRNA nanoplex to sensitize the cancer cells to PTT under moderate laser irradiation by down-regulating the increased BAG3 expression and enhancing apoptosis. Bialaphos 117-120 BAG cochaperone 3 Homo sapiens 187-191 22337942-7 2012 RESULTS: Collagen type I alpha-chain I (COL1A1) expression was increased in both painful PTT and AT compared with normal. Bialaphos 89-92 collagen type I alpha 1 chain Homo sapiens 40-46 27846626-7 2016 CONCLUSIONS: Stimulation of the contralateral VIM/VOP/ZI complex resulted in a noticeable improvement in tremor and recovery of independence in basic daily activities in patients with PTT. Bialaphos 184-187 vimentin Homo sapiens 46-56 26458166-5 2015 Molecular docking of PTT onto gp120 argued that, with sufficient linker length, the peptide SH could approach and disrupt several alternative gp120 disulfides. Bialaphos 21-24 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 30-35 26458166-5 2015 Molecular docking of PTT onto gp120 argued that, with sufficient linker length, the peptide SH could approach and disrupt several alternative gp120 disulfides. Bialaphos 21-24 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 142-147 26458166-6 2015 Inhibition of lysis by gp120 mAb 2G12, which binds at the base of the V3 loop, as well as disulfide mutational effects, argued that PTT-induced disruption of the gp120 disulfide cluster at the base of the V3 loop is an important step in lytic inactivation of HIV-1. Bialaphos 132-135 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 23-28 26458166-6 2015 Inhibition of lysis by gp120 mAb 2G12, which binds at the base of the V3 loop, as well as disulfide mutational effects, argued that PTT-induced disruption of the gp120 disulfide cluster at the base of the V3 loop is an important step in lytic inactivation of HIV-1. Bialaphos 132-135 Envelope surface glycoprotein gp160, precursor Human immunodeficiency virus 1 162-167 22337942-8 2012 Ciliary neurotrophic factor levels were increased in painful PTT only. Bialaphos 61-64 ciliary neurotrophic factor Homo sapiens 0-27