PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34242739-6	2021	RESULTS: Higher IL-6 levels, measured both in plasma and in TLR-2 stimulated blood, was significantly correlated with higher CTQ scores and lower cognitive and social cognitive function.	cysteine tryptophylquinone	125-128	interleukin 6	Homo sapiens	16-20
34242739-7	2021	Plasma IL-6 was further observed to partly mediate the association between higher CT scores and lower emotion recognition performance (CTQ total: betaindirect -.0234, 95% CI: -.0573 to -.0074; CTQ physical neglect: betaindirect=-.0316, 95% CI: -.0741 to -.0049).	cysteine tryptophylquinone	135-138	interleukin 6	Homo sapiens	7-11
34242739-7	2021	Plasma IL-6 was further observed to partly mediate the association between higher CT scores and lower emotion recognition performance (CTQ total: betaindirect -.0234, 95% CI: -.0573 to -.0074; CTQ physical neglect: betaindirect=-.0316, 95% CI: -.0741 to -.0049).	cysteine tryptophylquinone	193-196	interleukin 6	Homo sapiens	7-11
34242739-8	2021	Finally, sequential mediation was observed between plasma IL-6 levels and DMN connectivity in mediating the effects of higher CTQ on lower social cognitive function (betaindirect =-.0618, 95% CI: -.1523 to -0.285).	cysteine tryptophylquinone	126-129	interleukin 6	Homo sapiens	58-62
35078959-8	2022	Results: MDD subjects with high CTQ scores showed significantly decreased Nogo P3 amplitudes at the frontal, frontocentral, central, and parietal electrodes than those with low CTQ scores (all p < 0.01).	cysteine tryptophylquinone	32-35	reticulon 4	Homo sapiens	74-78
35093493-8	2022	CTQ total and emotional abuse scores were significantly correlated with smaller IL-6 diurnal variation as indexed by lower standard deviation across the measurement times (p=0.024 and p=0.008, respectively).	cysteine tryptophylquinone	0-3	interleukin 6	Homo sapiens	80-84
35093493-9	2022	Individuals with emotional abuse, as defined by a cut-off score of CTQ, showed flatter IL-6 rhythm than those without (p=0.031).	cysteine tryptophylquinone	67-70	interleukin 6	Homo sapiens	87-91
34607174-9	2021	Both COR and ACTH was positively and significantly correlated with the total scores of CTQ, HAMD, HAMA.	cysteine tryptophylquinone	87-90	proopiomelanocortin	Homo sapiens	13-17
35078959-9	2022	In Nogo P3, the source activities of the right cuneus, right posterior cingulate cortex, right precuneus, left supramarginal gyrus, and left lingual gyrus were significantly lower in the high CTQ group than in the low one (all p < 0.01).	cysteine tryptophylquinone	192-195	reticulon 4	Homo sapiens	3-7
35078959-10	2022	There were significant negative correlations between the total CTQ scores and the Nogo P3 amplitudes in the frontocentral (p = 0.03) and parietal regions (p = 0.02), which showed lower source activity in the Nogo P3 condition.	cysteine tryptophylquinone	63-66	reticulon 4	Homo sapiens	82-86
35078959-10	2022	There were significant negative correlations between the total CTQ scores and the Nogo P3 amplitudes in the frontocentral (p = 0.03) and parietal regions (p = 0.02), which showed lower source activity in the Nogo P3 condition.	cysteine tryptophylquinone	63-66	reticulon 4	Homo sapiens	208-212
32738671-10	2020	High-level CTQ scores relate significantly to DNA hypomethylation at CpG-site TPH2-8-237 in males (false discovery rate [FDR]-corrected p=0.038).	cysteine tryptophylquinone	11-14	tryptophan hydroxylase 2	Homo sapiens	78-82
33259836-7	2021	We found association between the mean BDNF methylation and total CTQ score in FEP, as well as between individual CpG sites and subtypes of trauma.	cysteine tryptophylquinone	65-68	brain-derived neurotrophic factor	Rattus norvegicus	38-42
35242246-10	2022	Both CTQ and TICS predicted MSD directly and indirectly through the levels of leptin.	cysteine tryptophylquinone	5-8	leptin	Homo sapiens	78-84
28754344-6	2017	Early trauma were negatively associated with BDNF serum levels (higher CTQ scores, lower BDNF; p=0.0019).	cysteine tryptophylquinone	71-74	brain derived neurotrophic factor	Homo sapiens	45-49
32618128-7	2020	RESULTS: Interaction of COMT polymorphism (rs4680, rs4633) and childhood emotional abuse (subscale of CTQ) predicted suicidal ideation in patients with PTSD.	cysteine tryptophylquinone	102-105	catechol-O-methyltransferase	Homo sapiens	24-28
30988377-6	2019	An interaction between the CTQ and the BDNF polymorphism significantly influenced PTSD symptom severity.	cysteine tryptophylquinone	27-30	brain derived neurotrophic factor	Homo sapiens	39-43
29527497-8	2018	P3 amplitudes of the differences between Nogo and Go ERP waves exhibited higher mean values in the low CTQ than the high CTQ group, with trending effects.	cysteine tryptophylquinone	103-106	reticulon 4	Homo sapiens	41-45
29527497-8	2018	P3 amplitudes of the differences between Nogo and Go ERP waves exhibited higher mean values in the low CTQ than the high CTQ group, with trending effects.	cysteine tryptophylquinone	121-124	reticulon 4	Homo sapiens	41-45
29527497-9	2018	In Nogo-P3, the source activities of the right anterior cingulate cortex, bilateral medial frontal cortex (MFC), bilateral superior frontal gyrus (SFG), and right precentral gyrus were significantly lower in the high CTQ than the low CTQ group.	cysteine tryptophylquinone	217-220	reticulon 4	Homo sapiens	3-7
32766325-13	2020	The correlation coefficient of ACE-ASF and CTQ was r = 0.56.	cysteine tryptophylquinone	43-46	angiotensin I converting enzyme	Homo sapiens	31-34
28754344-8	2017	A separate-slopes analysis showed that 5-HTTLPR significantly influenced the relationship between early trauma and adult BDNF (interaction of 5-HTTLPR with CTQ scores: p=0.0023), due to a significant relationship between trauma and BDNF in 5-HTTLPR*s carriers, but not among l/l homozygotes.	cysteine tryptophylquinone	156-159	brain derived neurotrophic factor	Homo sapiens	121-125
27577885-7	2017	We found that those with childhood trauma had a higher overall sAA response to the TSST, as seen in a repeated measures ANOVA (CTQ by time interaction: F(1.8,71.5) = 6.46, p = .01) and an independent samples t-test indicating higher sAA baseline to peak response (t = 3.22, p = .003).	cysteine tryptophylquinone	127-130	amylase alpha 1A	Homo sapiens	63-66
27043067-6	2017	There were positive correlations between serum orexin levels and CTQ total score and between orexin levels and some CTQ subscale scores, such as physical and emotional neglect, in patients.	cysteine tryptophylquinone	65-68	hypocretin neuropeptide precursor	Homo sapiens	47-53
27043067-6	2017	There were positive correlations between serum orexin levels and CTQ total score and between orexin levels and some CTQ subscale scores, such as physical and emotional neglect, in patients.	cysteine tryptophylquinone	116-119	hypocretin neuropeptide precursor	Homo sapiens	93-99
27577885-8	2017	There was also a positive correlation between sAA reactivity and the CTQ subscales of childhood physical abuse (r = .46, p = .005) and emotional abuse (r = .37, p = .024).	cysteine tryptophylquinone	69-72	amylase alpha 1A	Homo sapiens	46-49
25976322-7	2016	CTQ+ patients also exhibited increased baseline expression of gene transcripts related to inflammatory signaling, and baseline inflammatory markers including c-reactive protein, interleukin (IL)-6, and IL-1 receptor antagonist were positively correlated with depression, fatigue, and stress scores in CTQ+ but not CTQ- patients.	cysteine tryptophylquinone	0-3	C-reactive protein	Homo sapiens	158-176
25976322-7	2016	CTQ+ patients also exhibited increased baseline expression of gene transcripts related to inflammatory signaling, and baseline inflammatory markers including c-reactive protein, interleukin (IL)-6, and IL-1 receptor antagonist were positively correlated with depression, fatigue, and stress scores in CTQ+ but not CTQ- patients.	cysteine tryptophylquinone	0-3	interleukin 6	Homo sapiens	178-196
25976322-7	2016	CTQ+ patients also exhibited increased baseline expression of gene transcripts related to inflammatory signaling, and baseline inflammatory markers including c-reactive protein, interleukin (IL)-6, and IL-1 receptor antagonist were positively correlated with depression, fatigue, and stress scores in CTQ+ but not CTQ- patients.	cysteine tryptophylquinone	0-3	interleukin 1 receptor antagonist	Homo sapiens	202-226
22745815-5	2012	Furthermore, significant gene-environment interaction of COMT Val158Met genotype with CTQ was discerned with more maltreatment being associated with higher startle potentiation in val/val subjects but not in met carriers.	cysteine tryptophylquinone	86-89	catechol-O-methyltransferase	Homo sapiens	57-61
26313134-9	2015	Importantly, interaction analyses revealed a specific interaction between IFNgamma genotype (rs1861494) and early life stress affecting amygdala reactivity to emotional faces, resulting from a positive association between CTQ scores and amygdala reactivity in C allele carriers while this association was absent in T homozygotes.	cysteine tryptophylquinone	222-225	interferon gamma	Homo sapiens	74-82
24118915-6	2013	A significant interactive effect of childhood adversities and COMT genotype was observed: Homozygosity for the low-active met allele and high CTQ scores was associated with a significant increment of explained ASI variance [R(2) = 0.040, false discovery rate (FDR) corrected P = 0.04].	cysteine tryptophylquinone	142-145	catechol-O-methyltransferase	Homo sapiens	62-66
23522391-7	2013	There were significant associations between CTQ total score and earlier onset of illness, reduced level of psychosocial functioning (GAF; Global Assessment of Functioning) and decreased number of hospitalization, which mainly were due to the factor emotional abuse/neglect.	cysteine tryptophylquinone	44-47	fibroblast growth factor 9	Homo sapiens	133-136
23616424-9	2014	Less inhibition of the right IFC by dACC in males with higher CTQ scores improved inhibitory control ability.	cysteine tryptophylquinone	62-65	Acetyl-CoA carboxylase	Drosophila melanogaster	36-40
22404660-5	2014	RESULTS: Significant main effects of NPSR and CTQ as well as significant G x E were observed, with T/T homozygosity and a high CTQ score resulting in increased anxiety sensitivity.	cysteine tryptophylquinone	127-130	neuropeptide S receptor 1	Homo sapiens	37-41
23171514-9	2013	CES and CTQ correlated positively with activation in adjacent areas of the dorsal anterior cingulate cortex (dACC; BA 32, z = 3.70 and BA 24, z = 3.88 respectively).	cysteine tryptophylquinone	8-11	Acetyl-CoA carboxylase	Drosophila melanogaster	109-113
22422160-3	2012	METHOD: The data set of the SHIP-LEGEND study (n = 1668) was used to extract five items of the CTQ that optimally covered the five dimensions and showed a high correlation with the total score.	cysteine tryptophylquinone	95-98	inositol polyphosphate-5-phosphatase D	Homo sapiens	28-32
21978546-10	2012	Three CRHBP SNPs rs6453267, rs7728378 and rs10474485 showed a nominally significant interaction with the continuous CTQ score to predict suicide attempt; rs7728378 remained significant after FDR correction.	cysteine tryptophylquinone	116-119	corticotropin releasing hormone binding protein	Homo sapiens	6-11
21641725-6	2012	RESULTS: As hypothesized, high CTQ score was associated with a blunted cortisol and ACTH response to DEX/CRH challenge.	cysteine tryptophylquinone	31-34	proopiomelanocortin	Homo sapiens	84-88
21641725-6	2012	RESULTS: As hypothesized, high CTQ score was associated with a blunted cortisol and ACTH response to DEX/CRH challenge.	cysteine tryptophylquinone	31-34	corticotropin releasing hormone	Homo sapiens	105-108
17388633-1	2007	The electronic effects of the C-4 substituent on the physicochemical properties and reactivity of the 6,7-inodolequinone cofactors (CTQ and TTQ) have extensively been investigated with use of a series of C-4 substituted 6,7-inodolequinone derivatives (1-4).	cysteine tryptophylquinone	132-135	complement C4A (Rodgers blood group)	Homo sapiens	30-33
20881945-6	2010	CTQ total scores were positively correlated with overall change in IL-6 response, as well as the maximum IL-6 concentration during the TSST.	cysteine tryptophylquinone	0-3	interleukin 6	Homo sapiens	67-71
20881945-6	2010	CTQ total scores were positively correlated with overall change in IL-6 response, as well as the maximum IL-6 concentration during the TSST.	cysteine tryptophylquinone	0-3	interleukin 6	Homo sapiens	105-109
19736354-1	2009	CONTEXT: A previous study reported a gene x environment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1) was associated with protection against adult depressive symptoms in individuals who were maltreated as children (as assessed by the Childhood Trauma Questionnaire [CTQ]).	cysteine tryptophylquinone	316-319	corticotropin releasing hormone receptor 1	Homo sapiens	96-138
19736354-1	2009	CONTEXT: A previous study reported a gene x environment interaction in which a haplotype in the corticotropin-releasing hormone receptor 1 gene (CRHR1) was associated with protection against adult depressive symptoms in individuals who were maltreated as children (as assessed by the Childhood Trauma Questionnaire [CTQ]).	cysteine tryptophylquinone	316-319	corticotropin releasing hormone receptor 1	Homo sapiens	145-150
19736354-11	2009	CONCLUSIONS: A haplotype in CRHR1 has been suggested to exert a protective effect against adult depression among research participants who reported maltreatment on the CTQ, a measure that elicits emotional memories.	cysteine tryptophylquinone	168-171	corticotropin releasing hormone receptor 1	Homo sapiens	28-33
17608961-9	2008	Further, the functional catechol-O-methyltransferase (COMT) Val158Met polymorphism interacted significantly with total CTQ abuse scores to impact perceived dissociation.	cysteine tryptophylquinone	119-122	catechol-O-methyltransferase	Homo sapiens	24-52
17608961-9	2008	Further, the functional catechol-O-methyltransferase (COMT) Val158Met polymorphism interacted significantly with total CTQ abuse scores to impact perceived dissociation.	cysteine tryptophylquinone	119-122	catechol-O-methyltransferase	Homo sapiens	54-58