PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33815268-7	2021	This action was abrogated by the specific GPER antagonist G-15, leading to the conclusion that a GPER-dependent mechanism was involved.	G-15	58-62	G protein-coupled estrogen receptor 1	Mus musculus	42-46
34646075-8	2021	GPER-1 knockdown by siRNA reduced the cells number to 60% of siRNA-control-treated cells (P < .05), and GPER-1 antagonist, G-15 inhibited two HGSC cell lines proliferation (KF and UWB1.289) in a dose-dependent manner.	G-15	123-127	G protein-coupled estrogen receptor 1	Homo sapiens	104-110
33815268-7	2021	This action was abrogated by the specific GPER antagonist G-15, leading to the conclusion that a GPER-dependent mechanism was involved.	G-15	58-62	G protein-coupled estrogen receptor 1	Mus musculus	97-101
31126612-5	2019	We revealed no changes in ERRs expression but alterations in ERRbeta and gamma localization in G-15-treated cells when compared to control.	G-15	95-99	estrogen related receptor, beta	Mus musculus	61-68
32873626-9	2020	GPER1 inhibition using the antagonist G-15 reverses DEN-induced acute liver injury by suppressing Sin1 expression and mTORC2-AKT activation.	G-15	38-42	G protein-coupled estrogen receptor 1	Mus musculus	0-5
32873626-9	2020	GPER1 inhibition using the antagonist G-15 reverses DEN-induced acute liver injury by suppressing Sin1 expression and mTORC2-AKT activation.	G-15	38-42	mitogen-activated protein kinase associated protein 1	Mus musculus	98-102
32873626-9	2020	GPER1 inhibition using the antagonist G-15 reverses DEN-induced acute liver injury by suppressing Sin1 expression and mTORC2-AKT activation.	G-15	38-42	CREB regulated transcription coactivator 2	Mus musculus	118-124
32873626-9	2020	GPER1 inhibition using the antagonist G-15 reverses DEN-induced acute liver injury by suppressing Sin1 expression and mTORC2-AKT activation.	G-15	38-42	thymoma viral proto-oncogene 1	Mus musculus	125-128
32197950-5	2020	Using letrozole (an aromatase inhibitor) and G-15 (a GPER1-selective antagonist), we demonstrated that sodium arsenite-induced proliferation and migration is mediated by induction of aromatase enzyme and, at least in part, by GPER1 activation in MDA-MB-231 and MDA-MB-453 cells.	G-15	45-49	G protein-coupled estrogen receptor 1	Homo sapiens	53-58
32197950-5	2020	Using letrozole (an aromatase inhibitor) and G-15 (a GPER1-selective antagonist), we demonstrated that sodium arsenite-induced proliferation and migration is mediated by induction of aromatase enzyme and, at least in part, by GPER1 activation in MDA-MB-231 and MDA-MB-453 cells.	G-15	45-49	G protein-coupled estrogen receptor 1	Homo sapiens	226-231
31266599-9	2019	There was markedly greater abundances of Drosha after G-15 + BPA treatment, and this also occurred for Dicer after treatment with G-15 + TCBPA.	G-15	54-58	drosha ribonuclease III	Sus scrofa	41-47
30981690-6	2019	These actions were blocked by pretreating with GPER antagonist, G-15.	G-15	64-68	G protein-coupled estrogen receptor 1	Rattus norvegicus	47-51
28882636-8	2017	G-15 reversed the effects of E2 on GPR30 and AKT/mTOR, but did not alter the effect of BPA.	G-15	0-4	G protein-coupled estrogen receptor 1	Homo sapiens	35-40
28882636-8	2017	G-15 reversed the effects of E2 on GPR30 and AKT/mTOR, but did not alter the effect of BPA.	G-15	0-4	AKT serine/threonine kinase 1	Homo sapiens	45-48
28882636-8	2017	G-15 reversed the effects of E2 on GPR30 and AKT/mTOR, but did not alter the effect of BPA.	G-15	0-4	mechanistic target of rapamycin kinase	Homo sapiens	49-53
27760898-7	2017	However, blockade of Gper1 by its antagonist G-15 did not affect the inhibitory action of E2 on IGF-1-induced proliferation.	G-15	45-49	G protein-coupled estrogen receptor 1	Homo sapiens	21-26
25012534-8	2014	The selective GPR30 antagonist G-15 blocked these effects.	G-15	31-35	G protein-coupled estrogen receptor 1	Mus musculus	14-19
25781607-9	2015	Inhibiting GPR30 through treatment with the G-15 antagonist or specific shRNA impaired E2 effects.	G-15	44-48	G protein-coupled estrogen receptor 1	Homo sapiens	11-16
27222231-7	2017	Both G-15 (an antagonist of GPR30, 0.1 mumol/L) and PP2 (an inhibitor of Src, 2.0 mumol/L) inhibited 17beta-estradiol-induced activation of PI3K, reduced SC proliferation, and decreased messenger RNA (mRNA) and protein expression of S-phase kinase-associated protein 2 (Skp2).	G-15	5-9	G protein-coupled estrogen receptor 1	Homo sapiens	28-33
27222231-7	2017	Both G-15 (an antagonist of GPR30, 0.1 mumol/L) and PP2 (an inhibitor of Src, 2.0 mumol/L) inhibited 17beta-estradiol-induced activation of PI3K, reduced SC proliferation, and decreased messenger RNA (mRNA) and protein expression of S-phase kinase-associated protein 2 (Skp2).	G-15	5-9	S-phase kinase associated protein 2	Homo sapiens	233-268
27222231-7	2017	Both G-15 (an antagonist of GPR30, 0.1 mumol/L) and PP2 (an inhibitor of Src, 2.0 mumol/L) inhibited 17beta-estradiol-induced activation of PI3K, reduced SC proliferation, and decreased messenger RNA (mRNA) and protein expression of S-phase kinase-associated protein 2 (Skp2).	G-15	5-9	S-phase kinase associated protein 2	Homo sapiens	270-274
25969534-5	2015	GPER antagonist G-15 attenuated DHEA- and BSA-conjugated DHEA-stimulated pri-miR-21 transcription.	G-15	16-20	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
25969534-5	2015	GPER antagonist G-15 attenuated DHEA- and BSA-conjugated DHEA-stimulated pri-miR-21 transcription.	G-15	16-20	microRNA 21	Homo sapiens	77-83
25256868-11	2014	The specific PI3K inhibitor, LY290042, completely abolished Akt activation and eNOS phosphorylation in infarcted hearts treated with either oestradiol or oestradiol + G-15.	G-15	167-171	nitric oxide synthase 3	Rattus norvegicus	79-83
24718680-8	2014	The ICA- and ICT-stimulated ERK1/2 phosphorylation was blocked by pre-treatment of the cells with G-15 and AG-1478 or PD 98059.	G-15	98-102	mitogen-activated protein kinase 3	Homo sapiens	28-34
24704272-3	2014	The canonical estrogen receptor (ER) inhibitor ICI 182,780 completely abrogated the therapeutic effect of E2 while the GPR30 antagonist G-15 effected a slight but not significant reduction in neuroprotection.	G-15	136-140	G protein-coupled estrogen receptor 1	Homo sapiens	119-124
23610132-6	2013	The inhibitory effect of E2 on P2X3 currents was blocked by G-15, a selective antagonist to the GPR30 estrogen receptor.	G-15	60-64	purinergic receptor P2X 3	Rattus norvegicus	31-35
24376635-7	2013	The specific GPR30 antagonist G-15 significantly blocked effects of estradiol on LPS-induced TNF-alpha production, whereas an iER antagonist did not.	G-15	30-34	G protein-coupled estrogen receptor 1	Mus musculus	13-18
24376635-7	2013	The specific GPR30 antagonist G-15 significantly blocked effects of estradiol on LPS-induced TNF-alpha production, whereas an iER antagonist did not.	G-15	30-34	toll-like receptor 4	Mus musculus	81-84
24376635-7	2013	The specific GPR30 antagonist G-15 significantly blocked effects of estradiol on LPS-induced TNF-alpha production, whereas an iER antagonist did not.	G-15	30-34	tumor necrosis factor	Mus musculus	93-102
23755949-5	2013	INTERVENTION(S): Treatment with the histone deacetylase inhibitor romidepsin or suberoylanilide hydroxamic acid (SAHA), or with the GPER antagonist G-15.	G-15	148-152	G protein-coupled estrogen receptor 1	Homo sapiens	132-136
23755949-1	2013	OBJECTIVE: To investigate whether histone deacetylase inhibitors reduce the expression of the G-protein-coupled estrogen receptor (GPER) and whether the functional inhibition of GPER by the antagonist G-15 decreases the proliferation of endometriotic cells.	G-15	201-205	G protein-coupled estrogen receptor 1	Homo sapiens	178-182
23610132-6	2013	The inhibitory effect of E2 on P2X3 currents was blocked by G-15, a selective antagonist to the GPR30 estrogen receptor.	G-15	60-64	G protein-coupled estrogen receptor 1	Rattus norvegicus	96-101
21984484-8	2012	Importantly, based on co-exposure studies, G-15 blocked severe G-1-induced developmental toxicity, suggesting that G-1 toxicity is mediated via aberrant activation of GPER.	G-15	43-47	G protein-coupled estrogen receptor 1	Danio rerio	167-171
21865584-10	2011	The effects of G-1 on membrane potential, [Ca(2+)](i), and uterine contractility were prevented by pretreatment with G-15, a GPER antagonist, further supporting the involvement of GPER in these responses.	G-15	117-121	G protein-coupled estrogen receptor 1	Rattus norvegicus	125-129
21865584-10	2011	The effects of G-1 on membrane potential, [Ca(2+)](i), and uterine contractility were prevented by pretreatment with G-15, a GPER antagonist, further supporting the involvement of GPER in these responses.	G-15	117-121	G protein-coupled estrogen receptor 1	Rattus norvegicus	180-184
21349822-3	2011	A GPER-specific antagonist, G-15, increased spontaneous OM, indicating that the inhibitory estrogen actions on OM are mediated through Gper.	G-15	28-32	G protein-coupled estrogen receptor 1	Danio rerio	2-6
21349822-3	2011	A GPER-specific antagonist, G-15, increased spontaneous OM, indicating that the inhibitory estrogen actions on OM are mediated through Gper.	G-15	28-32	G protein-coupled estrogen receptor 1	Danio rerio	135-139