PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25657047-5	2015	MKP-1 knock-down increased 8Br-cAMP-induced promoter activity, while its over-expression produced the opposite effect.	8-Bromoadenosine 5'-monophosphate	27-30	dual specificity phosphatase 1	Mus musculus	0-5
29784881-7	2018	By solving the crystal structure of archaeal ADPGK in complex with 8-bromoadenosine phosphate (8-Br-AMP) at 1.81 A resolution, we identified the mechanism of inhibition.	8-Bromoadenosine 5'-monophosphate	95-103	ADP dependent glucokinase	Homo sapiens	45-50
29784881-8	2018	We observed that 8-Br-AMP is a competitive inhibitor of ADPGK and that the bromine substitution induces marked structural changes within the protein"s active site by engaging crucial catalytic residues.	8-Bromoadenosine 5'-monophosphate	17-25	ADP dependent glucokinase	Homo sapiens	56-61
29262534-9	2017	The chemical chaperone tauroursodeoxycholic acid resolved this ER stress and restored the balance of ISCs, an effect mimicked by the GUCY2C effector 8Br-cGMP.	8-Bromoadenosine 5'-monophosphate	149-152	guanylate cyclase 2c	Mus musculus	133-139
27412767-5	2016	In agreement, H89 (PKA inhibitor) or cotransfection with DN-CREB-M1 prevented the 8Br-cAMP-dependent increase in luciferase activity in cells transfected with pHO-1[-295/+74].LUC.	8-Bromoadenosine 5'-monophosphate	82-85	cAMP responsive element binding protein 1	Mus musculus	57-67
26146638-7	2015	The ability of ECs to migrate following Angs stimulation, evaluated by "scratch assay," was reduced by either 2-APB or 8Br-cADPR following Ang-2 stimulation and only slightly affected by 2-APB in cells stimulated with Ang-1.	8-Bromoadenosine 5'-monophosphate	119-122	angiopoietin 2	Homo sapiens	139-144
25543053-7	2015	Also, while 8Br-cAMP induced VASP Ser157 phosphorylation and reduced cell death, treatments with 8CPT-cGMP elevated VASP Ser239 phosphorylation and promoted apoptosis.	8-Bromoadenosine 5'-monophosphate	12-15	vasodilator stimulated phosphoprotein	Homo sapiens	29-33
18617565-8	2008	SNAP or 8Br-cGMP strongly suppressed TRPC6-like cation currents and membrane depolarization evoked by Arg(8)-vasopressin in A7r5 myocytes.	8-Bromoadenosine 5'-monophosphate	8-11	transient receptor potential cation channel subfamily C member 6	Homo sapiens	37-42
19961855-6	2010	8Br-cGMP and SIL reduced ET1-stimulated TRPC6 expression and NFAT dephosphorylation (activity).	8-Bromoadenosine 5'-monophosphate	0-3	endothelin 1	Homo sapiens	25-28
19961855-6	2010	8Br-cGMP and SIL reduced ET1-stimulated TRPC6 expression and NFAT dephosphorylation (activity).	8-Bromoadenosine 5'-monophosphate	0-3	transient receptor potential cation channel subfamily C member 6	Homo sapiens	40-45
23471219-8	2013	MKP-2 down-regulation by a short hairpin RNA (MKP-2 shRNA) raised the levels of phosphorylated ERK1/2 reached by 8Br-cAMP stimulation.	8-Bromoadenosine 5'-monophosphate	113-116	dual specificity phosphatase 4	Mus musculus	0-5
23471219-8	2013	MKP-2 down-regulation by a short hairpin RNA (MKP-2 shRNA) raised the levels of phosphorylated ERK1/2 reached by 8Br-cAMP stimulation.	8-Bromoadenosine 5'-monophosphate	113-116	dual specificity phosphatase 4	Mus musculus	46-51
23471219-8	2013	MKP-2 down-regulation by a short hairpin RNA (MKP-2 shRNA) raised the levels of phosphorylated ERK1/2 reached by 8Br-cAMP stimulation.	8-Bromoadenosine 5'-monophosphate	113-116	mitogen-activated protein kinase 3	Mus musculus	95-101
17406063-10	2007	On the other hand, Gsalpha-mediated stimulations of adenylyl cyclase by GTPgammaS, isoproterenol and FSK were significantly augmented in 8Br-cGMP-treated cells.	8-Bromoadenosine 5'-monophosphate	137-140	GNAS complex locus	Homo sapiens	19-26
17564679-5	2007	The cytoskeleton rearrangement induced by cGMP is prevented by the specific protein kinase G inhibitor Rp-8Br-PET-cGMPS and involves downstream inhibition of RhoA GTPase since is not observed in cells transfected with constitutively active RhoA.	8-Bromoadenosine 5'-monophosphate	106-109	ras homolog family member A	Rattus norvegicus	240-244
17032173-7	2007	In in vivo reporter gene assays employing PBREM (phenobarbital-responsive enhancer module) from CYP2B1, an AMPK inhibitor 8-bromo-AMP abolished phenobarbital-induced transactivation.	8-Bromoadenosine 5'-monophosphate	122-133	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	107-111
17032173-8	2007	In addition, Cyp2b10 gene expression was attenuated by 8-bromo-AMP.	8-Bromoadenosine 5'-monophosphate	55-66	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	13-20
16648664-2	2006	cADPR induced Ca2+ release in digitonin-permeabilized chromaffin cells and this was blocked by FK506 and rapamycin, ligands for FKBPs; 8Br-cADPR, a competitive antagonist for cADPR; and antibody for FKBP12/12.6, while it was enhanced by cyclosporin A.	8-Bromoadenosine 5'-monophosphate	135-138	peptidyl-prolyl cis-trans isomerase FKBP1A	Bos taurus	199-205
16691504-10	2006	On the other hand, the expression of GRP-78/Bip was 2.3-fold higher compared to that of GRP-94 in control cells, but after 8Br-cAMP treatment for 32 h, it was reduced by 3-fold.	8-Bromoadenosine 5'-monophosphate	123-126	heat shock protein family A (Hsp70) member 5	Homo sapiens	37-43
16691504-10	2006	On the other hand, the expression of GRP-78/Bip was 2.3-fold higher compared to that of GRP-94 in control cells, but after 8Br-cAMP treatment for 32 h, it was reduced by 3-fold.	8-Bromoadenosine 5'-monophosphate	123-126	heat shock protein family A (Hsp70) member 5	Homo sapiens	44-47
15003452-3	2004	We have determined crystal structures of the catalytic domain of PDE4B complexed with AMP (2.0 A), 8-Br-AMP (2.13 A) and the potent inhibitor rolipram (2.0 A).	8-Bromoadenosine 5'-monophosphate	99-107	phosphodiesterase 4B	Homo sapiens	65-70
15051728-8	2004	Both in vitro and intact cell studies demonstrate that the interaction between FHOD1 and PKGI is decreased 3- to 5-fold in the presence of the PKG activator, 8Br-cGMP.	8-Bromoadenosine 5'-monophosphate	158-161	formin homology 2 domain containing 1	Homo sapiens	79-84
15003452-0	2004	Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.	8-Bromoadenosine 5'-monophosphate	87-95	phosphodiesterase 4B	Homo sapiens	46-66
15003452-8	2004	8-Br-AMP binds in the syn conformation to the enzyme and demonstrates an alternative nucleotide-binding mode.	8-Bromoadenosine 5'-monophosphate	0-8	synemin	Homo sapiens	22-25
9491385-4	1998	In addition, the effect of oocytes on 8Br-cAMP-induced LHR mRNA steady-state expression by granulosa cells was assessed by RNase protection assays.	8-Bromoadenosine 5'-monophosphate	38-41	luteinizing hormone/choriogonadotropin receptor	Mus musculus	55-58
9826786-5	1998	Activation of protein kinase A with 8Br.cAMP strongly enhanced the number of cells that expressed the PEnk gene in slices prepared from the brains of newborn or 7-d-old rats.	8-Bromoadenosine 5'-monophosphate	36-39	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	14-30
9826786-5	1998	Activation of protein kinase A with 8Br.cAMP strongly enhanced the number of cells that expressed the PEnk gene in slices prepared from the brains of newborn or 7-d-old rats.	8-Bromoadenosine 5'-monophosphate	36-39	proenkephalin	Rattus norvegicus	102-106
9826786-7	1998	After stimulation with 8Br.cAMP or PACAP-38, PEnk mRNA-containing cells were found in the subventricular zone as well as in the adjacent area through which glial cells migrate on their way to the neocortex.	8-Bromoadenosine 5'-monophosphate	23-26	proenkephalin	Rattus norvegicus	45-49
12475389-0	2002	Protein tyrosine phosphatases are involved in LH/chorionic gonadotropin and 8Br-cAMP regulation of steroidogenesis and StAR protein levels in MA-10 Leydig cells.	8-Bromoadenosine 5'-monophosphate	76-79	steroidogenic acute regulatory protein	Mus musculus	119-123
11786298-2	2001	A stably transfected ABCA1 antisense cDNA cell line was created, which led to approximately 50-70% reductions in ABCA1 mRNA levels in basal and 8Br-cAMP-treated cells, and diminished to the same extent the 8Br-cAMP-mediated efflux of cholesterol to apolipoprotein AI and HDL.	8-Bromoadenosine 5'-monophosphate	144-147	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	21-26
11287349-2	2001	The purpose of the current study was to determine whether treadmill exercise and isolated muscle contractions in rat skeletal muscle increase the activity of the AMPK alpha 1 and AMPK alpha 2 catalytic subunits in a dose-dependent manner and to evaluate the effects of the putative AMPK inhibitors adenine 9-beta-D-arabinofuranoside (ara-A), 8-bromo-AMP, and iodotubercidin on AMPK activity and 3-O-methyl-D-glucose (3-MG) uptake.	8-Bromoadenosine 5'-monophosphate	342-353	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	162-166
11287349-5	2001	In isolated muscles, the putative AMPK inhibitors ara-A, 8-bromo-AMP, and iodotubercidin fully inhibited AICAR-stimulated AMPK alpha 2 activity and 3-MG uptake but had little effect on AMPK alpha 1 activity.	8-Bromoadenosine 5'-monophosphate	57-68	protein kinase AMP-activated catalytic subunit alpha 1	Rattus norvegicus	34-38
9491385-8	1998	In addition, since oocytes suppressed the 8Br-cAMP-induced increase in steady-state expression of mRNA for LHR, oocyte-derived factors probably suppress expression by acting downstream of FSH-induced elevation of granulosa cell cAMP.	8-Bromoadenosine 5'-monophosphate	42-45	luteinizing hormone/choriogonadotropin receptor	Mus musculus	107-110
7566966-5	1995	When 8Br-cAMP is withdrawn from the medium, cells enter S phase and Fra-2 protein levels and AP-1 DNA-binding activity decrease to their basal value indicating that a temporally correlation exists between the 8Br-cAMP-mediated induction of JunD/Fra-2 AP-1 complex and the 7TD1 and U266 cell growth inhibition.	8-Bromoadenosine 5'-monophosphate	5-8	fos-like antigen 2	Mus musculus	68-73
9221949-6	1997	Activation of protein kinases A and C with 8Br.cAMP and tetradecanoylphorbolacetate, respectively, enhanced the PEnk gene expression only during the G1 phase.	8-Bromoadenosine 5'-monophosphate	43-46	proenkephalin	Rattus norvegicus	112-116
7566966-5	1995	When 8Br-cAMP is withdrawn from the medium, cells enter S phase and Fra-2 protein levels and AP-1 DNA-binding activity decrease to their basal value indicating that a temporally correlation exists between the 8Br-cAMP-mediated induction of JunD/Fra-2 AP-1 complex and the 7TD1 and U266 cell growth inhibition.	8-Bromoadenosine 5'-monophosphate	5-8	jun D proto-oncogene	Mus musculus	240-244
7566966-5	1995	When 8Br-cAMP is withdrawn from the medium, cells enter S phase and Fra-2 protein levels and AP-1 DNA-binding activity decrease to their basal value indicating that a temporally correlation exists between the 8Br-cAMP-mediated induction of JunD/Fra-2 AP-1 complex and the 7TD1 and U266 cell growth inhibition.	8-Bromoadenosine 5'-monophosphate	5-8	fos-like antigen 2	Mus musculus	245-250
8393869-10	1993	Uptake of 2DOG by GLUT4 was inhibited by 8-bromo-AMP, but not by 8-bromo-cAMP, suggesting that the inhibitory effect did not involve activation of cAdPK.	8-Bromoadenosine 5'-monophosphate	41-52	solute carrier family 2 member 4	Canis lupus familiaris	18-23
7820071-8	1994	While the effect of 8Br.cAMP (1 mM) on PEnk-mRNA was enhanced, that of tetradecanoylphorbolacetate (0.1 microM) was abolished.	8-Bromoadenosine 5'-monophosphate	20-23	proenkephalin	Rattus norvegicus	39-43